Vinca Alkaloids: A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Vinca: A plant genus of the family APOCYNACEAE. Vinca rosea has been changed to CATHARANTHUS roseus.Colchicine: A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Vincristine: An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)P-Glycoprotein: A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).Vindesine: Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).Tubulin: A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.Microtubules: Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.Tubulin Modulators: Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Maytansine: An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Podophyllotoxin: A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.Bleomycin: A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.Early Detection of Cancer: Methods to identify and characterize cancer in the early stages of disease and predict tumor behavior.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Catharanthus: A plant genus of the family Apocynaceae. It is the source of VINCA ALKALOIDS, used in leukemia chemotherapy.Drug Resistance, Multiple: Simultaneous resistance to several structurally and functionally distinct drugs.Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Lung Neoplasms: Tumors or cancer of the LUNG.Mechlorethamine: A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Drug Screening Assays, Antitumor: Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.Antimitotic Agents: Agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS.Breast Neoplasms: Tumors or cancer of the human BREAST.Hydrocarbons, IodinatedColonic Neoplasms: Tumors or cancer of the COLON.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Depsipeptides: Compounds consisting of chains of AMINO ACIDS alternating with CARBOXYLIC ACIDS via ester and amide linkages. They are commonly cyclized.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Dacarbazine: An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)Cell Line, Tumor: A cell line derived from cultured tumor cells.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Stomach Neoplasms: Tumors or cancer of the STOMACH.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.KB Cells: This line KB is now known to be a subline of the ubiquitous KERATIN-forming tumor cell line HeLa. It was originally thought to be derived from an epidermal carcinoma of the mouth, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via contamination by HELA CELLS. The cells are positive for keratin by immunoperoxidase staining. KB cells have been reported to contain human papillomavirus18 (HPV-18) sequences.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Mitosis: A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Demecolcine: An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Azides: Organic or inorganic compounds that contain the -N3 group.Cancer Vaccines: Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Griseofulvin: An antifungal agent used in the treatment of TINEA infections.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.DiazomethaneCarcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Alkaloids: Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)Xenograft Model Antitumor Assays: In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.Urologic Neoplasms: Tumors or cancer of the URINARY TRACT in either the male or the female.Estramustine: A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Plant Tumors: A localized proliferation of plant tissue forming a swelling or outgrowth, commonly with a characteristic shape and unlike any organ of the normal plant. Plant tumors or galls usually form in response to the action of a pathogen or a pest. (Holliday, P., A Dictionary of Plant Pathology, 1989, p330)Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)National Cancer Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.Risk: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Rhodamine 123: A fluorescent probe with low toxicity which is a potent substrate for P-glycoprotein and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of P-glycoprotein in both normal and malignant cells. (Leukemia 1997;11(7):1124-30)Drug Antagonism: Phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy.Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.Prostate-Specific Antigen: A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Kinetics: The rate dynamics in chemical or physical systems.DNA, Neoplasm: DNA present in neoplastic tissue.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Drug Synergism: The action of a drug in promoting or enhancing the effectiveness of another drug.Survivors: Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.Receptor, erbB-2: A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)United StatesFlow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Rectal Neoplasms: Tumors or cancer of the RECTUM.Tamoxifen: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.Kidney Neoplasms: Tumors or cancers of the KIDNEY.Transplantation, Heterologous: Transplantation between animals of different species.DeoxycytidineAntibiotics, Antineoplastic: Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Odds Ratio: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Anthracyclines: Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Sarcoma 180Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Affinity Labels: Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids.Mitomycins: A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Cyclosporins: A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.Medical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.Radiotherapy: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.Neoplasms, Germ Cell and Embryonal: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)Neoplastic Stem Cells: Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Dysgerminoma: A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)Receptors, Progesterone: Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Genes, BRCA1: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways.Mammography: Radiographic examination of the breast.Antineoplastic Agents, Hormonal: Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Snails: Marine, freshwater, or terrestrial mollusks of the class Gastropoda. Most have an enclosing spiral shell, and several genera harbor parasites pathogenic to man.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Cytochalasins: 11- to 14-membered macrocyclic lactones with a fused isoindolone. Members with INDOLES attached at the C10 position are called chaetoglobosins. They are produced by various fungi. Some members interact with ACTIN and inhibit CYTOKINESIS.Microtubule-Associated Proteins: High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.Cystectomy: Used for excision of the urinary bladder.Taxoids: A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Nocodazole: Nocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules.Skin Neoplasms: Tumors or cancer of the SKIN.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.SEER Program: A cancer registry mandated under the National Cancer Act of 1971 to operate and maintain a population-based cancer reporting system, reporting periodically estimates of cancer incidence and mortality in the United States. The Surveillance, Epidemiology, and End Results (SEER) Program is a continuing project of the National Cancer Institute of the National Institutes of Health. Among its goals, in addition to assembling and reporting cancer statistics, are the monitoring of annual cancer incident trends and the promoting of studies designed to identify factors amenable to cancer control interventions. (From National Cancer Institute, NIH Publication No. 91-3074, October 1990)Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Liver Neoplasms: Tumors or cancer of the LIVER.Anticarcinogenic Agents: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.G2 Phase: The period of the CELL CYCLE following DNA synthesis (S PHASE) and preceding M PHASE (cell division phase). The CHROMOSOMES are tetraploid in this point.Mouth Neoplasms: Tumors or cancer of the MOUTH.Neoplasms, Hormone-Dependent: Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Molecular Targeted Therapy: Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Lumicolchicines: Three, alpha, beta, and gamma isomers of ultraviolet degradation products of colchicine that lack many of the physiological actions of the parent; used as experimental control for colchicine actions.Cell Growth Processes: Processes required for CELL ENLARGEMENT and CELL PROLIFERATION.Muscle Neoplasms: Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
... s are targets for anticancer drugs like the vinca alkaloid drugs vinblastine and vincristine, and Taxol. The anti-gout ... Anti-Cancer Agents. 5 (1): 65-71. doi:10.2174/1568011053352569. PMID 15720262. Karki R, Mariani M, Andreoli M, He S, Scambia G ... Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John ... These include paclitaxel, colchicine, and the vinca alkaloids, each of which have a distinct binding site on β-tubulin. Class ...
The plant produces about 130 of these compounds, including vinblastine and vincristine, two drugs used to treat cancer. ... Catharanthus roseus, known formerly as Vinca rosea, is a main source of vinca alkaloids, now sometimes called catharanthus ... Like genus Vinca, they are known commonly as periwinkles. There are eight known species. Seven are endemic to Madagascar, ... Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John ...
The Vinca alkaloids vincristine and vinblastine, used as anti-cancer drugs, were discovered in the 1950s from the Madagascar ... According to Cancer Research UK, "there is currently no strong evidence from studies in people that herbal remedies can treat, ... "Herbal medicine". Cancer Research UK. Retrieved 26 January 2017. Saslis-Lagoudakis, C. H.; Savolainen, V.; Williamson, E. M.; ... Drug discovery from plants continued to be important through the 20th century and into the 21st, with important anti-cancer ...
Vinblastine is mainly useful for treating Hodgkin's lymphoma, advanced testicular cancer and advanced breast cancer. ... The Vinca alkaloids bind to the β-subunit of tubulin dimers at a distinct region called the Vinca-binding domain. They bind to ... First anticancer drugs approved for clinical use were Vinca alkaloids, vinblastine and vincristine in the 1960s. They were ... Tubulin Microtubule Cancer Chemotherapy Drug design Vinblastine Vincristine Vinorelbine Vinflunine Cryptophycin Halichondrin B ...
Together they isolated the anti-cancer drug vinblastine from the leaves of the Madagascar periwinkle plant (vinca rosea) at the ... he remained an Honorary Senior Research Scientist in the department of cancer endocrinology at the British Columbia Cancer ... The discovery of vinblastine is generally considered a milestone in the development of chemotherapy. In 1960, he became ... In 2003, he was made a Member of the Order of Canada Canadian Medical Hall of Fame profile His cancer breakthrough started with ...
The original vinca alkaloids are natural products that include vincristine and vinblastine. Following the success of these ... Anti-Cancer Drugs (journal) Antimicrobial chemotherapy Cancer and nausea Cancer-related fatigue Chemo brain Chemotherapy ... There are a few possible causes of resistance in cancer, one of which is the presence of small pumps on the surface of cancer ... Vinca alkaloids are derived from the Madagascar periwinkle, Catharanthus roseus (formerly known as Vinca rosea). They bind to ...
Vinblastine and vincristine, chemotherapy medications used to treat several types of cancers, are found in the plant and are ... vinca-de-gato ("cats' vinca"), vinca-branca (white vinca), vinca or boa-noite in Portuguese (European), vinca del Cabo, vinca ... Many of the vinca alkaloids were first isolated from Catharanthus roseus, including vinblastine and vincristine used in the ... Other English names include '"Cape periwinkle" and "old-maid". It was formerly included in the genus Vinca as Vinca rosea. Two ...
This includes breast cancer and non-small cell lung cancer. It is given by injection into a vein or by mouth. Common side ... Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John ... Keglevich, Péter; Hazai, Laszlo; Kalaus, György; Szántay, Csaba (2012). "Modifications on the basic skeletons of vinblastine ... Vinorelbine is approved for the treatment of non-small-cell lung cancer. It is used off-label for other cancers such as ...
... such as the vinca alkaloids vinblastine and vincristine, which are formed from the coupling of catharanthine and vindoline. The ... "Safety and efficacy of vinorelbine in the treatment of non-small cell lung cancer". Clinical Medicine Insights: Oncology. 5: ... because they are extracted from vinca plants such as Vinca rosea (Catharanthus roseus); these are called vinca alkaloids. ... Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John ...
Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John ... The newer semi-synthetic chemotherapeutic agent vinorelbine is used in the treatment of non-small-cell lung cancer and is not ... Keglevich, Péter; Hazai, Laszlo; Kalaus, György; Szántay, Csaba (2012). "Modifications on the basic skeletons of vinblastine ... "Safety and efficacy of vinorelbine in the treatment of non-small cell lung cancer". Clinical Medicine Insights: Oncology. 5: ...
... the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as ... Cancers most likely to cause DVT are pancreatic cancer, stomach cancer, brain tumors, advanced breast cancer and advanced ... Invasion of bone by cancer is the most common source of cancer pain. About 70 percent of breast and prostate cancer patients, ... Cancer Treatment Reports. 1986;70:691-2. PMID 3708626. Twycross R & Bennett M. Cancer pain syndromes. In: Sykes N, Bennett MI ...
... and childhood cancers, as well as several other types of cancer and some non-cancerous conditions. Vinblastine is a chemical ... "Chemotherapy for Testicular Cancer". cancer.org. American Cancer Society. February 12, 2016. Retrieved June 22, 2017. Hirata, K ... American Cancer Society. May 31, 2016. Retrieved June 22, 2017. "Chemotherapy for Neuroblastoma". cancer.org. American Cancer ... "Chemotherapy for Non-Small Cell Lung Cancer". cancer.org. American Cancer Society. May 16, 2016. Retrieved June 22, 2017. " ...
... s are used in chemotherapy for cancer. They are a class of cell cycle-specific cytotoxic drugs that work by ... These compounds include vinblastine, vincristine, vindesine, and vinorelbine. Additional researched vinca alkaloids include ... Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. ... basionym Vinca rosea) and other vinca plants. The Madagascan periwinkle Catharanthus roseus L. is the source for a number of ...
... s are used in chemotherapy for cancer. They are a class of cell cycle-specific cytotoxic drugs that work by ... These compounds include vinblastine, vincristine, vindesine, and vinorelbine. Additional researched vinca alkaloids include ... Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. ... and the vinca alkaloids it produces from them: leurosine and the chemotherapy agents vinblastine and vincristine, all of ...
... an anticancer drug of the vinca alkaloid class. They also developed vinflunine, a fluorinated vinca alkaloid derivative ... Keglevich, Péter; Hazai, Laszlo; Kalaus, György; Szántay, Csaba (2012). "Modifications on the basic skeletons of vinblastine ... "Safety and efficacy of vinorelbine in the treatment of non-small cell lung cancer". Clinical Medicine Insights: Oncology. 5: ... Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John ...
This includes Hodgkin's lymphoma, non-small cell lung cancer, bladder cancer, brain cancer, melanoma, and testicular cancer. It ... Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of ... Vinblastine is a chemotherapy medication, typically used with other medications, to treat a number of types of cancer. ... Vinblastine works by blocking cell division. Vinblastine was isolated in 1958. It is on the World Health Organization's List of ...
... non-small cell lung cancer, bladder cancer, brain cancer, melanoma, and testicular cancer. It is given by injection into a ... Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting ... so it was hypothesized that vinblastine might be effective against cancers of the white blood cells such as lymphoma. ... "Vinblastine". Retrieved 28 November 2015.. *^ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. ...
Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John ... Keglevich, Péter; Hazai, Laszlo; Kalaus, György; Szántay, Csaba (2012). "Modifications on the basic skeletons of vinblastine ... Journal of the National Cancer Institute. 101 (1): 37-47. doi:10.1093/jnci/djn418. PMC 2639295 . PMID 19116379. Rybak LP, ... The vinca alkaloids, including vincristine, are also associated with reversible ototoxicity. Topical skin preparations such as ...
"The Vinca Alkaloids: A New Class of Oncolytic Agents" (pdf). Cancer Research. 23 (8 Part 1): 1390-1427. PMID 14070392. "Eli ... Sears, J.; Boger, D. (2015). "Total Synthesis of Vinblastine, Related Natural Products, and Key Analogues and Development of ... NCI Cancer Bulletin. Feb 23, 2010 [archived 2011-12-11];7(4):6. Graf, W. D.; Chance, P. F.; Lensch, M. W.; Eng, L. J.; Lipe, H ... It is a vinca alkaloid that can be obtained from the Madagascar periwinkle Catharanthus roseus. Vincristine is delivered via ...
May 2007). "Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate". Cancer Res. 67 (9): 4434-42. doi:10.1158/0008- ... vinblastine). EC145 was found to produce marked anti-tumor effect against well-established, subcutaneous FR-positive tumor ... Non-mucinous ovarian cancer (the majority of ovarian cancers) was the first tumor type to be associated with FR "over- ... Campbell IG, Jones TA, Foulkes WD, Trowsdale J (October 1991). "Folate-binding protein is a marker for ovarian cancer". Cancer ...
... the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as ... Paice JA, Ferrell B. The management of cancer pain. CA - A Cancer Journal for Clinicians. 2011;61(3):157-82. doi:10.3322/caac. ... A 2007 American Cancer Society study found that most patients did not recall being told to expect CIPN, and doctors monitoring ... Cancers of the Colon and Rectum: A Multidisciplinary Approach to Diagnosis and Management. Demos Medical Publishing. p. 233. ...
Vinblastine-used to treat leukaemia, Hodgkin's lymphoma, non-small cell lung cancer, breast cancer and testicular cancer. It is ... Docetaxel-used to treat breast, ovarian, and non-small cell lung cancer. Vinca alkaloids are amines produced by the ... Vindesine-used to treat leukaemia, lymphoma, melanoma, breast cancer, and lung cancer. Vinorelbine-used to treat breast cancer ... Paclitaxel-used to treat lung cancer, ovarian cancer, breast cancer, and advanced forms of Kaposi's sarcoma. ...
The original vinca alkaloids are natural products that include vincristine and vinblastine. Following the ... Cancer. 9 (1): 28-39. PMID 19104514. doi:10.1038/nrc2559.. *^ Hanahan D, Weinberg RA (Jan 2000). "The hallmarks of cancer". ... Vinca alkaloids are derived from the Madagascar periwinkle, Catharanthus roseus (formerly known as Vinca rosea). They ... Lung cancer. Cyclophosphamide, doxorubicin, vincristine,. CAV. Colorectal cancer. 5-fluorouracil, folinic acid, oxaliplatin. ...
Chemotherapy drugs thalidomide, the epothilones such as ixabepilone, the vinca alkaloids vincristine and vinblastine, the ... PCCI is often seen in patients treated for breast cancer, ovarian cancer, prostate cancer, and other reproductive cancers, as ... "Ocular toxicity and cancer chemotherapy." "Cancer", 78: 1359-1373. Doctors are finding it harder to deny "Chemobrain" The ... One underwent chemotherapy treatment for breast cancer, while the other did not have cancer and was not treated with ...
The technology has also been tested for treatment of prostate cancer, both in a dog model and in human prostate cancer ... Vinca alkaloids (Vinblastine#. *Vincristine#. *Vinflunine§. *Vindesine. *Vinorelbine#). Block microtubule disassembly. *Taxanes ... can penetrate cancer cells and, after being irradiated with light, destroy the cancer cells. ... J. Cancer. 95 (2): 189-96. doi:10.1038/sj.bjc.6603241. PMC 2360622. PMID 16819545.. ...
Cancer. Bleomycin is mostly used to treat cancer. This includes testicular cancer, ovarian cancer, and Hodgkin's ... Vinca alkaloids (Vinblastine#. *Vincristine#. *Vinflunine§. *Vindesine. *Vinorelbine#). Block microtubule disassembly. *Taxanes ... testicular cancer, ovarian cancer, and cervical cancer among others. Typically used with other cancer medications, it can ... It may also be put inside the chest to help prevent the recurrence of a pleural effusion due to cancer. For scarring down ...
Vinca alkaloids are used in chemotherapy for cancer. They are a class of cell cycle-specific cytotoxic drugs that work by ... These compounds include vinblastine, vincristine, vindesine, and vinorelbine. Additional researched vinca alkaloids include ... Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. ... and the vinca alkaloids it produces from them: leurosine and the chemotherapy agents vinblastine and vincristine, all of ...
Vinca alkaloids (vincristine, vinblastine). Anti-cancer. Rosy periwinkle. Various folk remedies across the world, including use ... Vinca alkaloids (vincristine, vinblastine). Anti-cancer. Rosy periwinkle. Various folk remedies across the world, including use ... Anti-cancer. Synthesized from podophyllotoxin, produced by the mandrake plant. Various remedies in Chinese, Japanese and ... Anti-cancer. Synthesized from podophyllotoxin, produced by the mandrake plant. Various remedies in Chinese, Japanese and ...
Vinca alkaloids synonyms, Vinca alkaloids pronunciation, Vinca alkaloids translation, English dictionary definition of Vinca ... Related to Vinca alkaloids: vinblastine, vincristine, paclitaxel, Taxanes. Vinca alkaloids. Cytotoxic drugs used to prevent the ... ATMs belong to a class of anti-cancer drug known as anti-mitotics, including the current taxanes and vinca alkaloids.. Novogen ... These include the taxanes (paclitaxel, docetaxel) and the vinca alkaloids (vincristine, vinblastine).. NOVOGEN ADDS TECHNOLOGY ...
Book] Cancer can be cured by Father Romano Zago. Allopathic cancer drugs from nature. [Vinca rosea.]Vinblastine sulfate: Damage ... HERBS FOR CANCER. [back] Cancer Therapies Herbs. [Here are 3 drugs made from herbs. The cancer industry likes you to think ... 1 - The ideal anti-cancer formula should attack and destroy cancer tissue. Of the herbs listed in the above formulas, here are ... Herbs used for cancer: Essiac formula: burdock root (Arctium lappa), slippery elm inner bark (Ulmus rubra), sheep sorrel (Rumex ...
... vinca alkaloids (e.g., vincristine or vinblastine); or other neurotoxic chemotherapy agents (e.g., bortezomib, lenalidomide, or ... Diagnosis of cancer,. *Received or currently receiving neurotoxic chemotherapy including, but not limited to, taxanes (e.g., ... Support Care Cancer. 2012 Mar;20(3):625-32. doi: 10.1007/s00520-011-1141-9. Epub 2011 Apr 12. ... Support Care Cancer. 2011 Jun;19(6):833-41. doi: 10.1007/s00520-010-0911-0. Epub 2010 May 25. ...
Vinca alkaloids (e.g., vincristine or vinblastine). * Experiencing pain or symptoms of peripheral neuropathy for at least 1 ... Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer. The safety and scientific ... Patients are stratified according to neurotoxic chemotherapy received (taxanes vs platinum-based compounds vs vinca alkaloids ... and other symptoms of peripheral neuropathy caused by chemotherapy in patients with cancer. ...
Vinblastine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Vinblastine is in a class of medications called vinca alkaloids. It works by slowing or stopping the growth of cancer cells in ... Vinblastine is also sometimes used to treat bladder cancer, certain types of lung cancer, Kaposis sarcoma, and certain brain ... Before receiving vinblastine,. *tell your doctor and pharmacist if you are allergic to vinblastine, any other medications, or ...
1) Vinca domain binders. - Vinca alkaloids (e.g vincristine, vinblastine) and Eribulin. - Used in chemotherapy to treat cancers ... Every cancer is its own unique disease:. - Genetic factors differ. - Time point of cancer formation. - Time point of diagnosis ... differences are in expression levels of genes but limited number of cancer specific mutations. - Result is that anti cancer ... 3) Do not fully understand the action of anti cancer drugs. 4) Complicated disease. 5) Cancer cell populations are highly ...
Acts primarily in M phase of cancer cell cycle Vinca alkaloid: Vincristine, Vinblastine (TOPNOTCH) ... Inhibits DNA topoisomerase I, cell cycle specific; For advanced ovarian cancer (2nd line), small cell lung cancer ... For chronic HBV, HCV infection, Kaposi sarcoma, genital warts, prevents dissemination of HZV in cancer patients and decreased ... Highly lipophilic allowing ease of passage through BBB into the CNS ; For brain tumors, melanoma, skin cancer ...
vinca alkaloids used to treat certain cancers, eg vincristine, vinblastine, vinflunine. * zolpidem. ...
Vinorelbine Definition Vinorelbine is a drug used to treat certain types of cancer. Vinorelbine is available under the trade ... a vinca alkaloid that is administered intravenously or orally in the treatment of advanced breast cancer and non-small-cell ... Vinorelbine is a semisynthetic derivative of vinblastine , a naturally occurring compound that is extracted from periwinkle ... Alternative trade… Paclitaxel , Paclitaxel Definition Paclitaxel is a drug used to treat certain types of cancer. Paclitaxel is ...
Vinca alkaloids are used in chemotherapy for cancer. They are a class of cell cycle-specific cytotoxic drugs that work by ... These compounds include vinblastine, vincristine, vindesine, and vinorelbine. Additional researched vinca alkaloids include ... Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. ... basionym Vinca rosea) and other vinca plants. The Madagascan periwinkle Catharanthus roseus L. is the source for a number of ...
Relieving such side effects is an important part of cancer care. This is called palliative care or supportive care. Talk with ... Nervous system side effects are common from cancer and cancer treatments. ... Vinca alkaloids, including vincristine (Vincasar), vinorelbine (Navelbine), and vinblastine (Velban). * Platinum-based drugs, ... Other cancer-related side effects. Other conditions or symptoms related to cancer or cancer treatments can affect the nervous ...
are taking vincristine, vinblastine and other "vinca alkaloids" (medicines used to treat cancer). ... Vinca Alkaloids. Most of the vinca alkaloids (e.g., vincristine and vinblastine) are substrates of CYP3A4. Concomitant ... Reserve azole antifungals, including Noxafil, for patients receiving a vinca alkaloid, including vincristine, who have no ... a low white blood cell count due to chemotherapy for blood cancers (hematologic malignancy) ...
Vinblastine sulfate blocks cell growth by stopping cell division and may kill cancer cells. It is a type of vinca alkaloid and ... vinblastine sulfate (vin-BLAS-teen SUL-fayt) listen A drug used to treat breast cancer and choriocarcinoma (a type of ... It is also used to treat Hodgkin lymphoma, non-Hodgkin lymphoma, Kaposi sarcoma, mycosis fungoides, and testicular cancer. It ... is also being studied in the treatment of other types of cancer. ...
... vinblastine concentration 2.50 mg/mL and vinblastine solution flow rate 6.7 mL/min). The vinblastine was characterized by ... It was concluded that physicochemical properties of crystalline vinblastine could be improved by physical modification, such as ... the supercritical antisolvent process was a powerful methodology for improving the physicochemical properties of vinblastine. ... The objective of the study was to prepare vinblastine microparticles by supercritical antisolvent process using N-methyl-2- ...
cyclophosphamide or vinca alkaloids such as vincristine or vinblastine for treatment of cancer ... Although not studied, Fluconazole may increase the plasma levels of the vinca alkaloids (e.g., vincristine and vinblastine) and ... Vinca Alkaloids. Vitamin A. Zidovudine. Oral hypoglycemics Clinically significant hypoglycemia may be precipitated by the use ... In patients with serious conditions such as AIDS or cancer, rare cases of severe rashes with skin peeling have been reported. ...
Examples of anti-carcinogens include vinblastine and vincristine from Catharanthus (Vinca) rosea and Taxolreg. (paclitaxel) ... New medicinal crops could assist in the battle with diseases such as cancer and acquired immunodeficiency syndrome (AIDS). ... Between 1960 and 1982, the National Cancer Institute screened 35,000 plant samples for anticancer activity. An anticancer drug ... proved effective for arresting ovarian and metastatic breast cancers and created a tremendous demand for the drug (Piesch et al ...
Vinblastine (Velbane): An anti-cancer drug in a class called vinca alkaloids. Vinblastine slows or stops the growth of cancer ... Vinorelbine (Navelbine): An anti-cancer drug in a class called vinca alkaloids. It slows or stops the growth of cancer cells in ... An anti-cancer drug that works by slowing or stopping the growth of cancer cells.. Cyclophosphamide (Cytoxan): An anti-cancer ... Methotrexate treats cancer by slowing the growth of cancer cells.. Mucosal surfaces: The moist tissues of the head and neck. ...
cyclophosphamide or vinca alkaloids such as vincristine or vinblastine for treatment of cancer ... Although not studied, fluconazole may increase the plasma levels of the vinca alkaloids (e.g., vincristine and vinblastine) and ... In patients with serious conditions such as AIDS or cancer, rare cases of severe rashes with skin peeling have been reported. ... In some patients, particularly those with serious underlying diseases such as AIDS and cancer, changes in renal and ...
Constipation can develop for several reasons in people with cancer. Learn about causes, symptoms and diagnosis, and preventing ... chemotherapy drugs such as the vinca alkaloids, which include vincristine (Oncovin), vinblastine (Velbe) or vinorelbine ( ... People with cancer can have constipation for a number of reasons, including the cancer itself or cancer treatments. The cells ... To find a cancer organization in your country, visit Union for International Cancer Control or International Cancer Information ...
Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 ... For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkins and non-Hodgkins lymphomas, mycosis ... The vinca alkaloids are considered to be cell cycle phase-specific.. Mechanism of action. The antitumor activity of vinblastine ... Vinblastine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and ...
Tubulins are targets for anticancer drugs like the vinca alkaloid drugs vinblastine and vincristine, and Taxol. The anti-gout ... Anti-Cancer Agents. 5 (1): 65-71. doi:10.2174/1568011053352569. PMID 15720262. Karki R, Mariani M, Andreoli M, He S, Scambia G ... Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John ... These include paclitaxel, colchicine, and the vinca alkaloids, each of which have a distinct binding site on β-tubulin. Class ...
Some critical aspects of cardiac side effects of cancer chemotherapy are also discussed, focusing on cardiac cytoskeleton and ... The application of plant bioactives in the treatment of cancer has resulted in increased therapeutic efficacy through targeting ... In this overview we describe the main plant-derived bioactive compounds used in cancer therapy which has the cell cytoskeleton ... Vincristine, vinblastine, and vindesine are the first vinca alkaloids used as antitumor drugs. Vinorelbine is the first new ...
Vinca alkaloids are commonly used in cancer therapy (50). However, they lack selectivity for tumor cells versus normal cells ... Vinblastine, infusion, bleomycin, and cis-dichlorodiammine-platinum chemotherapy in metastatic melanoma. Cancer. 1981;48(6): ... Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate. Cancer Res. 2007;67(9):4434-4442.. View this article via: ... Inhibition of tubulin-microtubule polymerization by drugs of the Vinca alkaloid class. Cancer Res. 1976;36(4):1499-1502.. View ...
AlkaloidVinorelbineCalled vinca alkaloidsVincristine and vinblastineRoseaPeriwinkleVindesineCompoundsTaxanesAnticancer drugsDocetaxelMicrotubuleEtoposide and teniposideMicrotubulesChemotherapy drugsColchicineDoxorubicinTumorChemotherapeutic agentsLungAllergic to vinblastineBelongs to a groupAlkaloids includeTesticularMitoticTherapiesInhibitorsVelbanLymphomaOverexpression of P-gpStructurally similarPatientsVincaleukoblastineTreatmentMitosisToxicityDosesBladderMoleculesMultidrug resistanceCytotoxicityBreast cancerSubstratesCellsMetabolismDrug
- Vinca alkaloids are a set of anti-mitotic and anti-microtubule alkaloid agents originally derived from the periwinkle plant Catharanthus roseus ( basionym Vinca rosea ) and other vinca plants. (wikipedia.org)
- It is a type of vinca alkaloid and a type of antimitotic agent. (cancer.gov)
- Antitumor alkaloid isolated from Vinca rosea. (rcsb.org)
- Vinblastine is a vinca alkaloid antineoplastic agent. (rcsb.org)
- Cersosimo RJ, Bromer R, Licciardello JTW, Ki Hong W (1983) Pharmacology, clinical efficacy and adverse effects of vindesine sulfate, a new vinca alkaloid. (springer.com)
- Cutts JH, Beer CT, Noble RL (1960) Biological properties of vincaleukoblastine, an alkaloid in Vinca rosea Linn, with reference to its antitumour action. (springer.com)
- Johnson IS (1968) Historical background of vinca alkaloid research and areas of future interest. (springer.com)
- A vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL). (drugbank.ca)
- A vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC. (drugbank.ca)
- Vinblastine sulfate is the salt of an alkaloid extracted from Vinca rosea Linn. (drugs.com)
- Chemical and physical evidence indicate that Vinblastine sulfate is a dimeric alkaloid containing both indole and dihydroindole moieties. (drugs.com)
- Vinblastine is a vinca alkaloid that binds to tubulin and inhibits microtubule formation in cells. (nih.gov)
- A vinca alkaloid related to VINBLASTINE that is used as a first-line treatment for NON-SMALL CELL LUNG CANCER, or for advanced or metastatic BREAST CANCER refractory to treatment with ANTHRACYCLINES. (nih.gov)
- In the 1950s, during the National Cancer Institute's screening program of natural products, an alkaloid stem wood extract from the Camptotheca acuminata, an oriental tree that is cultivated throughout Asia, was found to be active against L1210 murine leukemia. (barnardhealth.us)
- We show for the first time that betaIVb-tubulin, but not betaIVa-tubulin, plays a role in regulating vinca alkaloid chemosensitivity in PC cells. (garvan.org.au)
- The results from this study suggest betaIVb-tubulin may be a novel therapeutic target and predictor of vinca alkaloid sensitivity for PC and warrants further investigation. (garvan.org.au)
- vinca alkaloid - n any of several alkaloids (as vinblastine and vincristine) obtained esp. (academic.ru)
- It comes from a fungus and is similar to vinca alkaloid drugs. (academic.ru)
- And no one alkaloid on its own can KILL the cancer without HARMING you in the process . (hsionline.com)
- Modulation of vinca-alkaloid induced P-glycoprotein expression by indole-3-carbinol. (lifeextension.com)
- The results revealed that I3C significantly reversed the over-expression of P-gp in vinca-alkaloid induced drug resistance as evident by Western blotting using monoclonal antibody (clone JSB1). (lifeextension.com)
- This alkaloid inhibits the protein production cancer cells depend on to grow and flourish. (happyhomeinc.ca)
- A synthetic vinca alkaloid called vinflunine, developed in 2008, has since been approved in Europe for the treatment of certain types of bladder cancer. (happyhomeinc.ca)
- 4 First generation vinca alkaloids (vincristine) are associated with more severe neuropathy than the newer vinca alkaloids (vinorelbine, vinflunine). (thefreedictionary.com)
- Vinorelbine is a drug used to treat certain types of cancer. (encyclopedia.com)
- Vinorelbine is a semisynthetic derivative of vinblastine , a naturally occurring compound that is extracted from periwinkle plants. (encyclopedia.com)
- By disrupting this function vinorelbine inhibits cell replication, including the replication the cancer cells. (encyclopedia.com)
- Vinorelbine must only be administered by individuals experienced in the use of this cancer chemotherapeutic agent. (encyclopedia.com)
- The most commonly used substances are vinblastine and vincristine, other compounds are vinorelbine and vinflunine. (eurekaselect.com)
- In general, 4- chlorochablastine and 4-chlorochacristine caused these effects at concentrations higher than those needed for vinblastine, vincristine, and vinorelbine, but the potency was approximately in the range of vinflunine. (eurekaselect.com)
- Depierre A, Lemarie E, Dabouis G, Garnier G, Jacoulet P, Dalphin JC (1991) A phase II study of navelbine (vinorelbine) in the treatment of non-small-cell lung cancer. (springer.com)
- Vinca alkaloids such as vinblastine, vincristine, and vinorelbine are used extensively to treat acute lymphocytic leukemia, Hodgkin's lymphoma, testicular carcinoma, and a variety of other malignant diseases. (aacrjournals.org)
- In contrast, inhibition of betaIVb-tubulin in PC cells sensitized to vinca alkaloids (Vincristine, Vinorelbine and Vinblastine), which was accompanied by increased apoptosis and enhanced cell cycle arrest. (garvan.org.au)
- and cc that are warm to the vinca alkaloids vincristine, vinblastine, and vinorelbine are derived from the acute phase response, activated airway cells release cytokines, including interleukins, interferon, and ribavirin who received albumin was the first days oflactation, and composition ofthe ferns and newborn. (roanokechowan.edu)
- Conversely, the dose-limiting toxicity for vinblastine and vinorelbine is myelosuppression. (clicktocurecancer.info)
- Aside from vinblastine and vincristine, two others known for their cancer-fighting powers are vinorelbine and vindesine. (happyhomeinc.ca)
- Vinblastine is in a class of medications called vinca alkaloids. (medlineplus.gov)
- It belongs to a group of chemicals called vinca alkaloids. (encyclopedia.com)
- Improved through continual clinical trials over 50 years, these so-called 'vinca' alkaloids have been a key part of modern-day successes in curing childhood leukaemia and other cancers that were previously incurable. (cancer.org.au)
- Vinblastine belongs to a group of drugs called vinca alkaloids which work by slowing the growth and replication of cancer cells. (rxwiki.com)
- Vincristine sulfate belongs to a group of anticancer medicines called Vinca alkaloids. (mydr.com.au)
- Immunofluorescence study of the action of navelbine, vincristine and vinblastine on mitotic and axonal microtubules. (eurekaselect.com)
- Tubulysins bind to tubulin through the vinca site in a noncompetitive fashion with vinca alkaloids such as vincristine and vinblastine ( 8 ). (aacrjournals.org)
- A good example of this testing process on a natural derivative is the development of the drugs vincristine and vinblastine, extracted from the Madagascan periwinkle. (cancer.org.au)
- Vinpocetine should not be confused with the chemotherapy drugs vincristine and vinblastine, which are also made from compounds of the periwinkle plant. (mskcc.org)
- Two of these alkaloids, vincristine and vinblastine, are recognized by Western medicine as potent anticancer agents. (encyclopedia.com)
- 4 All but vindesine have been approved for use in the U.S., and vincristine and vinblastine are included in the World Health Organization's list of essential medicines. (happyhomeinc.ca)
- P eriwinkle plant (Vinca rosea Linn). (whale.to)
- Role of chance observations in chemotherapy: Vinca rosea. (eurekaselect.com)
- Johnson IS, Wright HF, Svoboda GH (1959) Experimental basis for clinical evaluation of anti-tumour principles derived from Vinca rosea Linn. (springer.com)
- from the rosy periwinkle * * * one of a group of antimitotic drugs (see cytotoxic drug) derived from the periwinkle (Vinca rosea). (academic.ru)
- Two of the most important chemotherapeutic drugs currently used were originally developed from a folk remedy containing the rosy periwinkle plant (Vinca rosea), which was used in Madagascar for treatment of diabetes. (quackwatch.org)
- The Latin name for this herb is Catharanthus roseus , but it was formerly classified as Vinca rosea , and is still called by that name in some of the herbal literature. (encyclopedia.com)
- The Madagascan periwinkle Catharanthus roseus L. is the source for a number of important natural products, including catharanthine and vindoline and the vinca alkaloids it produces from them: leurosine and the chemotherapy agents vinblastine and vincristine, all of which can be obtained from the plant. (wikipedia.org)
- Madagascan Periwinkle (Vinca Roseus):Itis a herb from which anti-cancer drugs have been produced. (amazonaws.com)
- In this respect it is worth remembering the periwinkle plant (Vinca major), which has given us two modern cytotoxic drugs, vinblastine and vincristine . (alternative-doctor.com)
- But if you go back to the first discovery of periwinkle and its anti-cancer activity, Canadian researchers in the 1950s found that the plant extract on its own could lower white blood cell counts . (hsionline.com)
- All the other compounds in the whole periwinkle want work IN CONCERT WITH the alkaloids to kill cancer AND protect YOU in the process . (hsionline.com)
- In supplement labeling, vinpocetine may also be called periwinkle or vinca minor extract. (mskcc.org)
- The vincas are natural compounds originally derived from the periwinkle plant. (clicktocurecancer.info)
- Rosy periwinkle (Catharanthus roseus), for example, a perennial plant native to Madagascar, is the basis for a number of commonly used cancer drugs that have been in use since the 1960s. (happyhomeinc.ca)
- Of the 70 different alkaloids found in periwinkle, the two primary compounds used in anticancer drugs are the powerful vinca alkaloids 2 vinblastine and vincristine. (happyhomeinc.ca)
- Patients are stratified according to neurotoxic chemotherapy received (taxanes vs platinum-based compounds vs vinca alkaloids vs combination vs other), status of neurotoxic chemotherapy (actively receiving therapy vs discontinued or completed), and duration of pain or neuropathy symptoms (1-3 months vs 3-6 months vs more than 6 months). (clinicaltrials.gov)
- The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. (rcsb.org)
- In this overview we describe the main plant-derived bioactive compounds used in cancer therapy which has the cell cytoskeleton as therapeutic target. (intechopen.com)
- Some critical aspects of cardiac side effects of cancer chemotherapy are also discussed, focusing on cardiac cytoskeleton and protective effect of plant-derived compounds. (intechopen.com)
- There has been tremendously increased interest during the past few years in both synthesis ( 1 - 6 ) and potential cancer treatment applications ( 7 - 11 ) of compounds in the tubulysin family because of their potent antiproliferative activity against multiple cancer cell lines with IC 50 in the nmol/L to pmol/L concentration range. (aacrjournals.org)
- One way to overcome these issues common to many cytotoxics is targeted delivery of compounds to cancer tissues. (aacrjournals.org)
- Believe it or not, a number of anti-cancer drugs that emerged at that time were based on plant compounds ! (hsionline.com)
- Vinblastine and vincristine are powerful compounds known as vinca alkaloids that fight cancer by blocking the process that allows blood vessels to grow within and deliver nutrients to malignant tumors (a.k.a. angiogenesis ). (hsionline.com)
- Both these vinca alkaloids work with your body's own immune system to fight the tumor - even if the tumor itself resists the cancer-cell-killing capacity of the compounds. (hsionline.com)
- Selected compounds were primarily evaluated for their antiproliferative activities against five human tumor cell lines including lung carcinoma (A549), triple-negative breast cancer (MDA-MB-231), estrogen receptor-positive and HER2-negative breast cancer (MCF-7), as well as HeLa (cervical carcinoma)-derived (KB) and its multidrug-resistant (MDR) subline (KB-VIN). (technologynetworks.com)
- This targeting of microtubules is thought to be one of the most important sites of antitumor activity discovered to date.63 These compounds act by directly binding to the 'vinca domain' on tubulin, blocking its ability to polymerize into microtubules.64 Microtubules are cytoskeletal fibers, comprising tubulin subunits, which are responsible for a variety of cellular functions crucial to mitosis, including chromosomal segration and maintenance of cellular shape. (clicktocurecancer.info)
- The vinca alkaloids thus prevent microtubule polymerization , as opposed to the mechanism of action of taxanes . (wikipedia.org)
- These include the taxanes (paclitaxel, docetaxel) and the vinca alkaloids (vincristine, vinblastine). (thefreedictionary.com)
- These drugs include vinca alkaloids , platinum-based drugs such as cisplatin, oxaliplatin and carboplatin, and the taxanes docetaxel and paclitaxel. (thefreedictionary.com)
- An anti-cancer drug that belongs to a group called taxanes and works by slowing or stopping the growth of cancer cells in the body. (everydayhealth.com)
- There are four classes of plant-derived anticancer drugs currently used in oncotherapy: vinca alkaloids (vinblastine, vincristine), epipodophyllotoxins (etoposide and teniposide), taxanes (paclitaxel and docetaxel), and camptothecin derivatives (camptothecin and irinotecan) [ 3 ]. (intechopen.com)
- To date, new generations of vinca alkaloids, camptothecins, and epothilones as well as a novel class of taxanes have been developed. (intechopen.com)
- 2001). Most of the commonly used chemotherapeutic agents are P-gp substrates which carry a positive charge (or are neutral) at physiological pH, are cyclic and hydrophobic molecules, such as anthracyclines (e.g. cloxorubicin), Vinca alkaloids (e.g. vinblastine), epipodophyllotoxins (e.g. etoposide), and taxanes (e.g. paclitaxel) (Sauna et al. (thefreelibrary.com)
- For example, the National Cancer Institute (NCI) commissioned botanists in the United States Department of Agriculture (USDA) in 1960 to provide 1,000 plants each year for the National Cancer Chemotherapy Service Center (CCNSC) for the screening of anticancer drugs. (selfgrowth.com)
- Chemotherapy is one way of treating cancer that uses anticancer drugs to inhibit cell division. (winshipcancerinstitute.org)
- It is involved in the efflux of several anticancer drugs, which leads to chemotherapy failure and multidrug resistance (MDR) in cancer cells. (thefreelibrary.com)
- Many clinically relevant anticancer drugs, such as Vinca alkaloids (vinblastine and vincristine), anthracyclines (doxorubicin and daunorubicin), taxenes (paclitaxel and docetaxel), epipodophylltoxins (etoposide and teniposide), camptothecins (topotecan), and anthracenes, are identified as modulators of human ABC transporters which offer great hope in successful cancer chemotherapy ( 36 ). (asm.org)
- Chemotherapy and Targeted Agents That May increase Risk of Cardiotoxicity Chemotherapy * Anthracyclines * 5-fluorouracil/capecitbine * Cyclophosphamide/ifosphamide * Paclitaxel/docetaxel * Cisplatin * Mitomycin C * Busulfan * Bleomycin * Mitoxantrone * Etoposide * Vinca alkaloids Targeted Therapies * Trastuzumab * Lapatinib * Sunitinib * Sorafenib * Rituximab * Imatinib mesylate * Bevacizumab * Interferons/interleukins * Arsenic trioxide Note. (thefreedictionary.com)
- These include extracts from the yew tree (docetaxel, paclitaxel), the opium and mandrake plants (epipodophyllotoxins) and from natural moulds that produce doxorubicin and related drugs, used effectively to treat breast cancer and lymphoma . (cancer.org.au)
- Both Paclitaxel and its analogue, Docetaxel have been evaluated for non small cell lung cancer. (indmedica.com)
- Vinblastine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. (rcsb.org)
- Interaction of vinblastine with calf brain microtubule protein. (eurekaselect.com)
- Colcemid and vinblastine are members of a large group of antimitotic drugs that inhibit microtubule assembly. (aacrjournals.org)
- Cell culture studies indicate that the most frequent mechanism of resistance to microtubule-destabilizing drugs such as Colcemid and vinblastine is P-glycoprotein-mediated mdr 4 ( 2 - 4 ). (aacrjournals.org)
- The mechanism of action of Vinblastine has been related to the inhibition of microtubule formation in the mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. (drugs.com)
- Disruption of microtubule dynamics by vinca alkaloids results in absence of a mitotic spindle, which leads to irregular dispersion of chromosomes throughout the cytoplasm. (clicktocurecancer.info)
- The vinca alkaloids and other microtubule disrupting agents have power to inhibit malignant angiogenesis in vitro. (happyhomeinc.ca)
- They are a class of cell cycle -specific cytotoxic drugs that work by inhibiting the ability of cancer cells to divide: Acting upon tubulin, they prevent it from forming into microtubules , a necessary component for cellular division . (wikipedia.org)
- Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on microtubules in vitro. (eurekaselect.com)
- Various Vinca alkaloids (e.g., vincristine, vinblastine, etc.) depolymerize microtubules and prevent the attachment of kinetochores to spindle microtubules resulting in an inhibition of chromosome alignment during mitosis. (aacrjournals.org)
- Vinca alkaloids are known as 'spindle poisons,' because of their ability to inhibit the assembly of microtubules. (clicktocurecancer.info)
- Microtubules are responsible for a variety of other cellular functions as well, including cellular transport and motility, phagocytosis, neurotransmission, and axonal transport.65 Inhibition of these nonmitotic cellular functions may account for some of the adverse effects common to the vinca alkaloids. (clicktocurecancer.info)
- Vinblastine is used in combination with other chemotherapy drugs to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cell that normally fights infection), and cancer of the testicles. (medlineplus.gov)
- It can occur from some chemotherapy drugs used in conventional cancer treatment. (cancer.org)
- Nausea and vomiting are common side effects of chemotherapy drugs that are used to treat cancer. (cancersupportivecare.com)
- These include paclitaxel, colchicine, and the vinca alkaloids, each of which have a distinct binding site on β-tubulin. (wikipedia.org)
- Furthermore, colchicine is also an old medicine targeted for the treatment of cancer, fibrosis and inflammation. (selfgrowth.com)
- the term is often used of those which cause metaphase-arrest such as colchicine and the vinca alkaloids . (academic.ru)
- Using an approach involving exchanging homologous segments of MDR1 and MDR2 and site-directed mutagenesis, we have demonstrated that MDR1 residues Q330, V331, and L332 in transmembrane domain 6 are sufficient to allow an MDR2 backbone in the N-terminal half of P-gp to transport several MDR1 substrates, including bisantrene, colchicine, vinblastine, and rhodamine-123. (asm.org)
- It may also be used to treat breast cancer that has not improved after treatment with other medications and gestational trophoblastic tumors (a type of tumor that forms inside a woman's uterus while she is pregnant) that has not improved after surgery or treatment with other medications. (medlineplus.gov)
- A drug used to treat breast cancer and choriocarcinoma (a type of gestational trophoblastic tumor) that have not gotten better with other treatment. (cancer.gov)
- Deep vein thrombosis Between 15 and 25 percent of deep vein thrombosis (DVT) is caused by cancer (often by a tumor compressing a vein). (wikipedia.org)
- Nerve infiltration or compression Infiltration or compression of a nerve by a primary tumor causes peripheral neuropathy in one to five percent of cancer patients. (wikipedia.org)
- Brachial plexopathy Brachial plexopathy is a common product of Pancoast tumor, lymphoma and breast cancer, and can produce severe burning dysesthesic pain on the back of the hand, and cramping, crushing forearm pain. (wikipedia.org)
- Compelling data demonstrate that centrosomes are implicated in cancer, because there are important oncogenic and tumor suppressor proteins that are localized in this organelle and drive centrosome aberrations. (dovepress.com)
- CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSC) and overexpressed on the surface of a variety of cancer cells. (cancer.gov)
- Any strategy by which a cytotoxic drug is targeted to the tumor, thus increasing the therapeutic index of the drug, is a way of improving cancer chemotherapy and minimizing systemic toxicity. (barnardhealth.us)
- We found that the serum concentration of Hcy fluctuated in circulation coinciding with that of tumor marker in individual cancer patients unless taking anti-neoplastic drug. (lifeextension.com)
- One of the essential traits of cancer progression is the underlying high mutational capacity of tumor cells [ 7 - 9 ], having as a consequence the rapid adaptive capacity of the disease. (biomedcentral.com)
- As a consequence, cancer cells which have lost essential genes by a mutation are eliminated from the tumor population. (biomedcentral.com)
- Certain complications can only be managed by a physician experienced in the use of cancer chemotherapeutic agents. (encyclopedia.com)
- During early chemotherapeutic era, non small cell cancer was considered resistant to all chemotherapeutic agents. (indmedica.com)
- Apart from their anti-diabetic activities, some of the extracts have potential for the development of chemotherapeutic agents for the treatment of cervical cancer. (biomedcentral.com)
- Vinblastine is also sometimes used to treat bladder cancer, certain types of lung cancer, Kaposi's sarcoma, and certain brain tumors. (medlineplus.gov)
- Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells. (thefreedictionary.com)
- Exposure to asbestos fibers has been linked to many diseases, including lung and laryngeal cancers. (everydayhealth.com)
- Cancer of the lung, a largely preventable disease caused mainly by cigarette smoking, continues to increase at an alarming rate. (chestofbooks.com)
- One of the most difficult aspects of the lung cancer problem is the lack of effective ways to detect this disease at an early stage. (chestofbooks.com)
- This drug may also be used for other types of cancers (such as lung cancer). (kaiserpermanente.org)
- Melanoma and breast and lung cancer account for 90 percent of such cases. (wikipedia.org)
- Dorsal root ganglion inflammation Small-cell lung cancer and, less often, cancer of the breast, colon or ovary may produce inflammation of the dorsal root ganglia (fig. 5), precipitating burning, tingling pain in the extremities, with occasional "lightning" or lancinating pains. (wikipedia.org)
- About 70 percent of breast and prostate cancer patients, and 40 percent of those with lung, kidney and thyroid cancers develop bone metastases. (wikipedia.org)
- They are very many types of cancer such as breast cancer, lung cancer and even prostate cancer. (winshipcancerinstitute.org)
- A taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. (drugbank.ca)
- Green tea (Camellia sinensis):Green Tea has been shown to reduce the incidence of a variety of cancers, including the most impossible to cure, pancreatic cancer, and also to prevent stomach, colon, and breast and lung cancer. (amazonaws.com)
- Studies have implicated betaIVa-tubulin or betaIVb-tubulin expression with chemoresistance in prostate, breast, ovarian and lung cancer. (garvan.org.au)
- Etoposide was approved by FDA in 1983 for use in patients with refractory testicular tumors, small-cell lung cancer, nonlymphocytic leukemias, and non-Hodgkins lymphoma (424). (quackwatch.org)
- The incidence of lung cancer each year worldwide is over six hundred thousand cases. (indmedica.com)
- Except for patients with stage I non small cell lung cancer (NSCLC) and limited disease small cell lung cancer (SCLC), all require systemic chemotheraphy. (indmedica.com)
- ii) It improves five year survival by 50% in respectable lung cancer. (indmedica.com)
- It is also used to treat Hodgkin lymphoma, non-Hodgkin lymphoma, Kaposi sarcoma, mycosis fungoides, and testicular cancer. (cancer.gov)
- Vinblastine is a prescription medication used to treat a variety of cancers including Hodgkin's disease, lymphoma, breast cancer, testicular cancer , and a certain type of uterine cancer . (rxwiki.com)
- To its credit, chemotherapy was found to increase five-year survival of testicular cancer by 40.3 percent and Hodgkin's disease by 37.7 percent. (greensmoothiegirl.com)
- A number of studies in vitro and in vivo have demonstrated that Vinblastine sulfate produces a stathmokinetic effect and various atypical mitotic figures. (drugs.com)
- Aurora inhibitors - Aurora kinases regulate cell cycle transit from G2 through cytokinesis and, thus, are targets in cancer therapy [Andrews PD, Knatko E, Moore WJ, Swedlow JR. Mitotic mechanics: the auroras come into view. (academic.ru)
- Various cancer therapies use plant-derived bioactive products. (intechopen.com)
- Histone Deacetylases And Cancer: Causes and Therapies. (patents.com)
- One of the most misleading myths of modern medicine is that conventional cancer doctors reject 'natural' therapies in favour of artificial or 'unnatural' cancer treatments. (cancer.org.au)
- aromadendrene,13-sitosterol-0-glucoside, and 13-carotene), and alkaloids (glaucine, harmine, and sanguinarine) were evaluated as potential P-gp inhibitors (transporter activity and expression level) in P-gp expressing Caco-2 and CEM/ADR5000 cancer cell lines. (thefreelibrary.com)
- Discovery and development of tubulin inhibitors - Tubulin inhibitors interfere directly with the tubulin system which is in contrast to those drugs acting on DNA for cancer chemotherapy. (academic.ru)
- Posted May 2, 2015 FRIDAY, May 1, 2015 (HealthDay News) -- A lifetime of vigorous exercise may lower the risk of non-Hodgkin's lymphoma -- a form of cancer that affects the lymph nodes, according to a new study. (livingnaturally.com)
- Chemotherapy also contributes to better five-year survival rates for childhood acute myeloid leukemia (85 percent), and rare cancers like Burkitt's lymphoma, which has a cure rate of over 90 percent. (greensmoothiegirl.com)
- And in its natural form, it can beat back blood cancers like lymphoma WITHOUT all the toxic side effects. (hsionline.com)
- 2002). An overexpression of P-gp has been frequently observed in drug resistant tumour cells and has been proposed as a cause for the failure of a broad range of anti-cancer drugs (Dean et al. (thefreelibrary.com)
- Quantization of immunostained tissue sections using image analysis technique revealed that vinblastine/vincristine induced overexpression of P-gp was effectively reversed by I3C. (lifeextension.com)
- PURPOSE: This randomized phase III trial is studying BAK gel to see how well it works compared with a placebo in treating peripheral neuropathy caused by chemotherapy in patients with cancer. (clinicaltrials.gov)
- PURPOSE: This randomized phase III trial is studying how well lamotrigine works in reducing pain, numbness, tingling, and other symptoms of peripheral neuropathy caused by chemotherapy in patients with cancer. (clinicaltrials.gov)
- Compare the efficacy of lamotrigine vs placebo in reducing pain and symptoms of chemotherapy-induced peripheral neuropathy in patients with cancer. (clinicaltrials.gov)
- During the 1960's, the ability of drugs to produce complete, long-term remissions, perhaps cures, in some patients with widespread, progressive cancer has been unequivocally established. (chestofbooks.com)
- For many patients with different types of cancer, physicians are prescribing drugs with the. (chestofbooks.com)
- One study found that infection was the cause of pain in four percent of nearly 300 cancer patients referred for pain relief. (wikipedia.org)
- Between 40 and 80 percent of patients with cancer pain experience neuropathic pain. (wikipedia.org)
- Meninges Ten percent of patients with cancer spreading to different parts of the body develop meningeal carcinomatosis, where metastatic seedlings develop in the meninges (outer lining) of both the brain and spinal cord (with possible invasion of the brain or spinal cord). (wikipedia.org)
- Spinal cord compression About three percent of cancer patients experience spinal cord compression, usually from expansion of the vertebral body or pedicle (fig. 1) due to metastasis, sometimes involving collapse of the vertebral body. (wikipedia.org)
- Tubulin-targeted drugs are the mainstay of current cancer treatments, but many patients eventually still progress due to the rise of resistance and side effects leading to dose reductions or discontinuations. (aacrjournals.org)
- When it is detected at an early stage it is curable but in most cases chances of survival for cancer patients is very minimal because cancer treatments such as chemotherapies are very expensive and most people cannot afford it. (winshipcancerinstitute.org)
- Probably we have heard or even seen how cancer patients suffer and even end up dying. (winshipcancerinstitute.org)
- Sometimes these cancer patients are very stubborn and most of them are afraid to start chemotherapy because of financial issues. (winshipcancerinstitute.org)
- Many cancer patients find it hard to talk to their loved ones about this killer disease. (winshipcancerinstitute.org)
- The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. (cancer.gov)
- A study in Japan showed green tea to reduce the likelihood of metastasis in patients with breast cancer and overall improved prognosis. (amazonaws.com)
- Still, the main action of green tea appears to be preventative and its effects in patients with cancer are largely unknown.4. (amazonaws.com)
- See WARNINGS for the treatment of patients given intrathecal Vinblastine sulfate injection. (drugs.com)
- Pharmacokinetic studies in patients with cancer have shown a triphasic serum decay pattern following rapid intravenous injection. (drugs.com)
- it is especially observed in posttransplant patients and patients with acquired immunodeficiency syndrome (AIDS) or a prior cancer diagnosis [ 11 ]. (hindawi.com)
- In a study in 23 patients with advanced colorectal cancer , 17 generated anti-anti-idiotype responses, and 13 of these were proven to be true. (barnardhealth.us)
- In 2004, my first year of cancer, a groundbreaking study was published in the Journal of Clinical Oncology examining the five-year survival rates of cancer patients in the U.S. and Australia. (greensmoothiegirl.com)
- In this study, only 3,306 of 154,971 American cancer patients had five-year survival that could be credited to chemotherapy. (greensmoothiegirl.com)
- This is not unlike when my first oncologist told me I had a 60 percent chance of living five years, which was the average survival of all cancer patients lumped together. (greensmoothiegirl.com)
- Chemosensitivity and Endocrine Sensitivity in Clinical Luminal Breast Cancer Patients in the Prospective Neoadjuvant Breast Registry Symphony Trial (NBRST) Predicted by Molecular Subtyping. (bireme.br)
- OBJECTIVE: The purpose of this predefined substudy was to compare MammaPrint/BluePrint with conventional 'clinical' immunohistochemistry/fluorescence in situ hybridization (IHC/FISH) subtyping in 'clinical luminal' [HR+/human epidermal growth factor receptor 2-negative (HER2-)] breast cancer patients to predict treatment sensitivity. (bireme.br)
- METHODS: NBRST IHC/FISH HR+/HER2- breast cancer patients (n = 474) were classified into four molecular subgroups by MammaPrint/BluePrint subtyping: Luminal A, Luminal B, HER2, and Basal type. (bireme.br)
- U.S. cancer patients who use traditional Chinese medicine do so mainly for pain control, reduction in side effects of conventional treatment, and enhanced quality of life, in the opinion of several members of the Advisory Panel for this project (8). (quackwatch.org)
- BACKGROUND: We were interested to know why cancer patients are frequently associated with elevated circulating total homocysteine (tHcy) even though they are not treated with anti-folate drugs. (lifeextension.com)
- Join us in this session and learn about the current role that immunotherapy plays in improving outcomes for cancer patients. (vetvine.com)
- The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have. (medlineplus.gov)
- It is important for you to tell your doctor how you are feeling during your treatment with vinblastine injection. (medlineplus.gov)
- Tell your doctor and pharmacist about all the medications you are taking so they can check whether any of your medications may increase the risk that you will develop hearing problems during your treatment with vinblastine. (medlineplus.gov)
- Nervous system symptoms may lead to a cancer diagnosis, appear soon after treatment, or may appear several years after treatment. (cancer.net)
- Some symptoms caused by cancer treatment will go away after treatment ends, but some may be ongoing. (cancer.net)
- It is also being studied in the treatment of other types of cancer. (cancer.gov)
- Certain drugs that are used to treat cancer or the side effects of treatment can also cause constipation. (cancer.ca)
- The application of plant bioactives in the treatment of cancer has resulted in increased therapeutic efficacy through targeting the cytoskeleton, respectively, prevention of the injury of cytoskeletal components elicited by chemotherapeutics. (intechopen.com)
- Chemotherapy is routinely used for cancer treatment. (intechopen.com)
- Within a few short years, drug treatment of cancer has become an essential part of the practice of medicine. (chestofbooks.com)
- The treatment of cancer may cause health problems for childhood cancer survivors months or years after successful treatment has ended. (cigna.com)
- Doctors are studying the late effects caused by cancer treatment. (cigna.com)
- The ability of healthy tissue affected by cancer treatment to repair itself. (cigna.com)
- Because childhood cancer survivors are living longer, they are having more late effects after cancer treatment. (cigna.com)
- Cyclodextrin polymerized nanoparticles are an enabling technology for the safe and effective delivery of tubulysins for the treatment of cancer. (aacrjournals.org)
- Investigated for the treatment of cancer. (drugbank.ca)
- Fosbretabulin has been investigated for the treatment of Anaplastic Thyroid Cancer. (drugbank.ca)
- Lorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others. (drugbank.ca)
- Thus, by defining the mechanism of cell death on G 2 checkpoint abrogation we show a highly improved strategy for an anticancer treatment by the combined use of UCN-01 with abrogators of the survivin/Aurora B-dependent antiapoptotic pathway that retains the selectivity for p53-defective cancer cells. (aacrjournals.org)
- Its first recorded use in the United States as a treatment for cancer occurred in the early 1920s but it was judged too toxic and studies ceased. (alternative-doctor.com)
- The herb comfrey, also recommended as an alternative cancer treatment, actually causes cancer. (cancer.org.au)
- It is used for the treatment of various cancers. (mydr.com.au)
- Vinblastine treatment results in the formation of paracrystalline aggregates in the cells, which are formed from tightly packed tubulin molecules.This was achieved using exogenous expression of fluorescent proteins conjugated with tubulin and time-lapse microscopy.It may be concluded that the indicated method was successful for the real-time analysis of paracrystal formation in human cells. (nih.gov)
- Vinblastine treatment results in the formation of paracrystalline aggregates in the cells, which are formed from tightly packed tubulin molecules. (nih.gov)
- Vinblastine is therefore widely used for cancer treatment. (nih.gov)
- This suggested that the localization of the RBM8A proteins was adjacent to the tubulin molecules prior to vinblastine treatment. (nih.gov)
- As shown in Fig. 1A-C, tubulin cytoplasmic localization was verified in the cells without vinblastine treatment. (nih.gov)
- In the vinblastine-treated cells, characteristic paracrystal tube-like structure formation could clearly be detected (Fig. 1G-I). Thus, vinblastine treatment caused paracrystal formation in the A549 cells. (nih.gov)
- By a News Reporter-Staff News Editor at Cancer Weekly -- Androgen deprivation therapy is a common and effective treatment for advanced prostate cancer. (livingnaturally.com)
- The natural product, mitomycin C, has been the most widely used quinone-containing alkylating agent in the clinic, but other quinone-containing alkylating agents like porfiromycin, diaziquone, carbazilquinone, triaziquone and EO9 havealso been used in the clinic for the treatment of cancer. (bioscience.org)
- This chapter describes the current and past clinical uses of these agents in the treatment of cancer and discusses new agents that are currently in clinical trials. (bioscience.org)
- I've adopted Chris as my "little brother" (even though I already have six biological brothers) because our deep research in the area of cancer treatment alternatives is so compatible and similar. (greensmoothiegirl.com)
- A major factor impacting the conclusion of the 2 percent study was that the five-year survival benefit for many cancers after chemo treatment was zero. (greensmoothiegirl.com)
- rhizoxin - A substance that is being studied in the treatment of cancer. (academic.ru)
- The gum of its bark, seeds and leaves are used in the treatment of cancer in traditional medicine. (biomedcentral.com)
- It is a central feature of many current forms of folk and traditional medicine, e.g., traditional Chinese medicine, Native American healing, and curanderismo, and is used in the treatment of a wide range of disorders, including cancer. (quackwatch.org)
- Herbal products are also used in unconventional cancer treatment in the United States, drawing from traditional practices in most cases, but generally offered outside of the overall context of traditional medicine and folk healing. (quackwatch.org)
- Several chemotherapeutic drugs used in conventional cancer treatment were developed from botanical sources. (quackwatch.org)
- Most of the recent scientific literature on immune-stimulating effects and adjunctive therapeutic use of herbal medicine in cancer treatment has been published by researchers in China, Japan, and Korea. (quackwatch.org)
- The present investigation suggests that I3C can significantly inhibit the P-gp over-expression and may have utility as a dietary adjuvant in the treatment of cancer for the reversal of multiple drug resistance. (lifeextension.com)
- Thuja occidentalis (family: Cupressaceae) has been used as antiseptic, expectorant, diuretic and in the treatment of cancer and removal of kidney stones in different systems of medicine. (oalib.com)
- The invention also relates to methods for making such complexes and compositions comprising alpha (2) macroglobulin complexes, isolated from the serum of a mammal, wherein such compositions are used in methods for the treatment and prevention of cancer and infectious disease. (justia.com)
- The invasive and metastatic processes as well as a series of metabolic abnormalities resulting from the cancer cause illness and eventual death of the patient unless the neoplasm can be eradicated with treatment. (blogspot.com)
- The antitumor activity of vinblastine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. (rcsb.org)
- Other studies indicate that Vinblastine sulfate has an effect on cell-energy production required for mitosis and interferes with nucleic acid synthesis. (drugs.com)
- In addition, glutamic acid and aspartic acid have protected mice from lethal doses of Vinblastine sulfate. (drugs.com)
- People who have to get repeated doses of vinblastine may feel symptoms of peripheral neuropathy (tingling sensation and numbness in the fingers and toes), this needs to be reported to your doctor immediately. (rxwiki.com)
- The concentration of vinblastine that prevents polymerization by 50% was 4.3 × 10 -7 mole/liter for a tubulin concentration of 3.0 mg/ml, and this concentration is consistent with levels achieved in vivo following routine pharmacological doses in humans. (aacrjournals.org)
- In combination with antibodies against vascular endothelial growth factor, low doses of [vinblastine] increased antitumor response considerably, even in tumors resistant to direct cytotoxic effects of the drug. (happyhomeinc.ca)
- These two lines with different chemosensitivity are thus considered to be a useful model for developing new chemotherapeutic strategies against multidrug resistant bladder cancer. (nih.gov)
- oak Viscum (Quercus) is recommended for cancer of the digestive tract (oesophagus, stomach, gall bladder, colon and so on). (alternative-doctor.com)
- The cancers for which chemo reportedly made no difference toward five-year survival were melanoma, multiple myeloma, and soft-tissue sarcoma, as well as pancreatic, uterine, prostate, bladder, and kidney cancers. (greensmoothiegirl.com)
- Exposure to chemicals may occur by virtue of occupational and environmental means as well as life style habits the association of aniline dye exposure and bladder cancer is one such example. (blogspot.com)
- Since the 1950s, drug developers in many countries and regions, including the United States, began to focus on natural small molecules that have anti-cancer effects. (selfgrowth.com)
- Strategies commonly used for this purpose are liposomal encapsulation ( 14 , 15 ), conjugation to antibodies or small molecules targeted to antigens that are up-regulated in certain cancer types ( 16 , 17 ), and polymer conjugation ( 18 , 19 ). (aacrjournals.org)
- It plays a crucial role in the development of multidrug resistance (MDR) by effluxing therapeutical agents out of cancer cells (Gottesman et al. (thefreelibrary.com)
- Expression of the multidrug transporter P-glycoprotein (P-gp) is one of the major causes of multidrug resistance in cancer cells. (asm.org)
- Cancers most likely to cause DVT are pancreatic cancer, stomach cancer, brain tumors, advanced breast cancer and advanced pelvic tumors. (wikipedia.org)
- Posted November 7, 2015 TUESDAY, Oct. 27, 2015 (HealthDay News) -- A new study out of Europe supports the notion that drinking raises women's risk of breast cancer. (livingnaturally.com)
- However, during the last decade, the use of new oral formulations of the existing drug 5-flu-orouracil for common tumour types as colorectal and breast cancer has rapidly increased. (barnardhealth.us)
- However, in breast cancer. (roanokechowan.edu)
- Momordica charantia has edible fruits and leaves which are used to treat leprosy, jaundice, hemorrhoids and breast cancer, rheumatism, gout, liver and spleen diseasses and as an abortifacient. (dhushara.com)
- It works by slowing or stopping the growth of cancer cells in your body. (medlineplus.gov)
- Vinblastine sulfate blocks cell growth by stopping cell division and may kill cancer cells. (cancer.gov)
- An antibiotic used only to treat cancer, bleomycin slows or stops the growth of cancer cells in the body. (everydayhealth.com)
- An anti-cancer drug that works by slowing or stopping the growth of cancer cells. (everydayhealth.com)
- Cyclophosphamide slows or stops the growth of cancer cells in the body. (everydayhealth.com)
- An antibiotic that is used to slow or stop the growth of cancer cells in the body. (everydayhealth.com)
- It resembles a nutrient cancer cells need to grow. (everydayhealth.com)
- Cancer cells take up the drug, which interferes with their growth. (everydayhealth.com)
- Methotrexate treats cancer by slowing the growth of cancer cells. (everydayhealth.com)
- Most oral, head, and neck cancers begin in the cells of the mucosal surfaces. (everydayhealth.com)
- The cytoskeleton is one of the main therapeutic targets in cancer cells [ 2 ]. (intechopen.com)
- Since cancer is a disease in which some body cells seem to be out of control, knowledge of cellular biochemistry is basic to ultimate understanding of the cancerous process. (chestofbooks.com)
- The activity of VileX against cultured L1210 cells is four times that of the parent drug VileE and comparable with that of vinblastine (VBL). (springer.com)
- Expression of CD47, and its interaction with SIRPa, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, which allows cancer cells to proliferate. (cancer.gov)
- Studies in laboratories have shown that extracts of ashwagandha kill some cancer cells and enhance some immune cells. (amazonaws.com)
- It is thought that the structure of Ashwagandha extracts may damage the cancer cells ability to generate the energy it needs to reproduce.3. (amazonaws.com)
- Here, we present molecular changes in both α- and β-tubulin that are found in Colcemid- and vinblastine-resistant CHO cells. (aacrjournals.org)
- Normal cells are able to recover within a few minutes but for cancer cells this change is irreversible. (alternative-doctor.com)
- Perhaps the best that has been shown is that benzaldehyde, which is made from laetrile in the body, does have success against cancer cells. (alternative-doctor.com)
- Finally, amygdalin was shown to sensitize some cancer cells to radiation, which would in theory help someone who had opted for radiotherapy. (alternative-doctor.com)
- But diet will not cure cancer, which directly attacks the body's cells in a highly destructive and relentless way. (cancer.org.au)
- Such a malignant disease can only be cured if the cancer cells are surgically removed before the cancer has spread or if they are destroyed with chemotherapy and/or radiotherapy. (cancer.org.au)
- This may be caused by the cancer cells producing a particular kind of biological agent that interferes with the function of the nerves. (cancer.org)
- Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells. (thefreelibrary.com)
- 2007). Substances that completely, or partly, inhibit P-gp function and/or expression may prevent the undesirable efflux of anticancer agents from MDR cancer cells. (thefreelibrary.com)
- Vincristine stops the cancer cells growing and eventually kills them. (mydr.com.au)
- Immunostaining and time-lapse analysis of vinblastine-induced paracrystal formation in human A549 cells. (nih.gov)
- A549 cells were treated with a vinblastine solution and fixed. (nih.gov)
- To confirm paracrystal formation in the A549 cells, the cells were treated with vinblastine for 12 h and the paracrystals that formed were stained with an anti-tubulin antibody, as described in previous studies (26,27). (nih.gov)
- any such substance, as certain drugs used to destroy cancer cells. (academic.ru)
- MDR in cancer cells is an obstacle to effective chemotherapy. (asm.org)
- ABC transporters, including ABCB1, ABCC1, and ABCG2, play an important role in the development of frequently encountered MDR in cancer cells ( 29 ). (asm.org)
- If it kills your cancer… it's going to take a whole lot of healthy cells with it. (hsionline.com)
- And a blood cancer like leukemia is, of course, characterized by having too many white blood cells. (hsionline.com)
- As cancer cells exhibit a large number of mutations, the identification of these mutated genes' SL partners may provide specific anti-cancer drug candidates, with minor perturbations to the healthy cells. (biomedcentral.com)
- Under this perspective, targeting essential genes in anti-cancer therapy could kill malignant cells, but might result to be lethal for healthy cells too. (biomedcentral.com)
- The cancer industry likes you to think this is improving on herbal medicine , and most weeks you can read about some herb with wonderful properties that isn't any use until they extract some part of it and turn it into a highly toxic drug, as idiotic as turning vegetables into drugs before we can eat them, but no one is allowed to think about the logical absurdities. (whale.to)
- An anti-cancer drug that is in a class of drugs called alkylating agents. (everydayhealth.com)
- The first glimmering that acute leukemia, an important cause of death due to cancer in children, could respond to drug therapy came in November 1947. (chestofbooks.com)
- Caron JM, Herwood M. Vinblastine, a chemotherapeutic drug, inhibits palmitoylation of tubulin in human leukemic lymphocytes. (eurekaselect.com)
- Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. (cancer.gov)
- Side effects of prescription drugs can sometimes be worse than the disease the drug is designed to treat and can increase your risk of cancer, and many other debilitating and life-threatening diseases, and death. (greensmoothiegirl.com)
- Cancer drug development has exploded since then into a multi billion dollar industry. (academic.ru)
- Vinblastine is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. (chemocare.com)
- The over-expression of mdr-1 gene transcript P-glycoprotein (P-gp), responsible for multiple drug resistance, is one of the major obstacles in cancer chemotherapy. (lifeextension.com)
- Paclitaxel is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. (chemocare.com)
- Our work provides a complementary alternative to the current methods for drug discovering and gene target identification in anti-cancer research. (biomedcentral.com)