A calcium channel blocker that is a class IV anti-arrhythmia agent.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Simultaneous resistance to several structurally and functionally distinct drugs.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A fluorescent probe with low toxicity which is a potent substrate for P-glycoprotein and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of P-glycoprotein in both normal and malignant cells. (Leukemia 1997;11(7):1124-30)
The relationship between the dose of an administered drug and the response of the organism to the drug.
A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Countries in the process of change with economic growth, that is, an increase in production, per capita consumption, and income. The process of economic growth involves better utilization of natural and human resources, which results in a change in the social, political, and economic structures.
A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.
The appearance of the face that is often characteristic of a disease or pathological condition, as the elfin facies of WILLIAMS SYNDROME or the mongoloid facies of DOWN SYNDROME. (Random House Unabridged Dictionary, 2d ed)
The head of a long bone that is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Laws and regulations, pertaining to the field of veterinary medicine, proposed for enactment or enacted by a legislative body.
A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Hard or soft soluble containers used for the oral administration of medicine.
Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is characterized by PAIN of moderate to severe intensity; aggravated by physical activity; and associated with NAUSEA and / or PHOTOPHOBIA and PHONOPHOBIA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Mechanical food dispensing machines.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The hollow, muscular organ that maintains the circulation of the blood.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.

Antiproteinuric efficacy of verapamil in comparison to trandolapril in non-diabetic renal disease. (1/2289)

BACKGROUND: Non-dihydropyridine calcium antagonists such as verapamil are equally effective in reducing proteinuria as ACE inhibitors in hypertensive patients with diabetic nephropathy. To date it is unknown whether verapamil elucidates such an antiproteinuric capacity in non-diabetic renal disease. METHODS: We performed a double-blind, placebo-controlled, random cross-over study which compared the antiproteinuric effect of 6 weeks treatment with verapamil SR (360 mg) to that of the ACE inhibitor trandolapril (4 mg), and their fixed combination vera/tran (180 mg verapamil SR and 2 mg trandolapril) in 11 non-diabetic patients with proteinuria of 6.6 (5.1-8.8) g/day, a creatinine clearance of 87 (74-106) ml/min, and a 24-h blood pressure of 136/85 (126/76-157/96) mmHg at baseline. RESULTS: Twenty-four-hour mean arterial pressure did not change during verapamil, whereas both trandolapril and vera/tran induced a significant reduction in MAP. Verapamil showed no significant effects on renal haemodynamics. Trandolapril and vera/tran did not significantly change GFR, but ERPF increased and FF decreased during both treatments (P<0.05). The antiproteinuric response of verapamil was significantly less compared to that of trandolapril and vera/tran (-12% (-17/-1) vs -51% (-56/-25) and -41% (-50/-19) respectively). The blood pressure and antiproteinuric response during verapamil tended to be greater in hypertensive patients than in normotensive patients, although this difference was not significant. Baseline blood pressure was related to the change in blood pressure during verapamil (r = -0.70; P < 0.02). CONCLUSIONS: The antiproteinuric and antihypertensive response of verapamil is less than that of the ACE inhibitor trandolapril in patients with non-diabetic renal disease. In contrast to the antiproteinuric response of trandolapril, the antiproteinuric reponse of verapamil seems to be completely dependent from effective blood pressure reduction. The fixed combination of verapamil and ACE inhibition at half doses has similar effects as ACE inhibition at full dose.  (+info)

Effect of verapamil treatment on compensatory renal growth in mice. (2/2289)

Calcium has been shown to control the proliferation of various cells in vitro and in vivo. In this study we have attempted to modify compensatory renal growth by pharmacological interventions in mice who have undergone uninephrectomy. The effect of a calcium channel blocker verapamil was investigated. Unilateral nephrectomy of intact male mice produced the expected increase in weight of the remaining kidney by 67.5+/-8.1%. This rise was accompanied by a proportional increase in RNA. In mice, cell hypertrophy was found to be a major factor in compensatory renal growth. Verapamil given in a i.p. dose of 1.0 or 2.0 mg/day/mouse attenuated the growth of the remaining kidney so that its weight rose by only 48.2+/-6% and 28.2+/-4.4 %, respectively. In vivo administration of verapamil decreased the degree of compensatory renal growth and this growth inhibiting effect was directly proportional to the dose.  (+info)

Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol. (3/2289)

Class I P-glycoproteins (Pgp) confer multidrug resistance in tumors, but the physiologic function of Pgp in normal tissues remains uncertain. In cells derived from tissues that normally express Pgp, recent data suggest a possible role for Pgp in cholesterol trafficking from the plasma membrane to the endoplasmic reticulum. We investigated the esterification of plasma membrane cholesterol under basal conditions and in response to sphingomyelinase treatment in transfected and drug-selected cell lines expressing differing amounts of functional class I Pgp. Compared with parental NIH 3T3 fibroblasts, cells transfected with human multidrug resistance (MDR1) Pgp esterified more cholesterol both without and with sphingomyelinase. Esterification also was greater in drug-selected Dox 6 myeloma cells than parental 8226 cells, which express low and non-immunodetectable amounts of Pgp, respectively. However, no differences in total plasma membrane cholesterol were detected. Transfection of fibroblasts with the multidrug resistance-associated protein (MRP) did not alter esterification, showing that cholesterol trafficking was not generally affected by ATP-binding cassette transporters. Steroidal (progesterone, dehydroepiandrosterone) and non-steroidal antagonists (verapamil, PSC 833, LY335979, and GF120918) were evaluated for effects on both cholesterol trafficking and the net content of 99mTc-Sestamibi, a reporter of drug transport activity mediated by Pgp. In Pgp-expressing cells treated with nonselective and selective inhibitors, both the kinetics and efficacy of inhibition of cholesterol esterification differed from the antagonism of drug transport mediated by Pgp. Thus, although the data show that greater expression of class I Pgp within a given cell type is associated with enhanced esterification of plasma membrane cholesterol in support of a physiologic function for Pgp in facilitating cholesterol trafficking, the molecular mechanism is dissociated from the conventional drug transport activity of Pgp.  (+info)

Functional and molecular characterization of a volume-sensitive chloride current in rat brain endothelial cells. (4/2289)

1. Volume-activated chloride currents in cultured rat brain endothelial cells were investigated on a functional level using the whole-cell voltage-clamp technique and on a molecular level using the reverse transcriptase-polymerase chain reaction (RT-PCR). 2. Exposure to a hypotonic solution caused the activation of a large, outward rectifying current, which exhibited a slight time-dependent decrease at strong depolarizing potentials. The anion permeability of the induced current was I- (1.7) > Br- (1.2) > Cl- (1.0) > F- (0. 7) > gluconate (0.18). 3. The chloride channel blocker 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB, 100 microM) rapidly and reversibly inhibited both inward and outward currents. The chloride transport blocker 4,4'-diisothiocyanatostilbene-2, 2'-disulphonic acid (DIDS, 100 microM) also blocked the hypotonicity-induced current in a reversible manner. In this case, the outward current was more effectively suppressed than the inward current. The volume-activated current was also inhibited by the antioestrogen tamoxifen (10 microM). 4. The current was dependent on intracellular ATP and independent of intracellular Ca2+. 5. Activation of protein kinase C by phorbol 12,13-dibutyrate (PDBu, 100 nM) inhibited the increase in current normally observed following hypotonic challenge. 6. Extracellular ATP (10 mM) inhibited the current with a more pronounced effect on the outward than the inward current. 7. Verapamil (100 microM) decreased both the inward and the outward hypotonicity-activated chloride current. 8. RT-PCR analysis was used to determine possible molecular candidates for the volume-sensitive current. Expression of the ClC-2, ClC-3 and ClC-5 chloride channels, as well as pICln, could be shown at the mRNA level. 9. We conclude that rat brain endothelial cells express chloride channels which are activated by osmotic swelling. The biophysical and pharmacological properties of the current show strong similarities to those of ClC-3 channel currents as described in other cell types.  (+info)

Effects of captopril and enalaprilat on intracellular Ca2+, Na+ contents and pH in hypoxic and reoxygenated cardiomyocytes. (5/2289)

AIM: To study the mechanisms of captopril (Cap) and enalaprilat (Ena) protective effects on hypoxic and reoxygenated cardiac myocytes. METHODS: Using fluorescent probes Fura 2-AM, BCECF/AM, SBFI/AM combined with computer image processing techniques to measure intracellular ion concentrations. RESULTS: [Ca2+]i (165 +/- 8 nmol.L-1) and [Na+]i (9.2 +/- 0.8 mmol.L-1) were higher but [pH]i (6.7 +/- 0.3) was lower in hypoxic and reoxygenated myocytes (196 +/- 14 nmol.L-1, 9.3 +/- 1.3 mmol.L-1, 6.61 +/- 0.19, respectively) than in normal ones. Cap and Ena reduced [Ca2+]i (149 +/- 11 and 152 +/- 10 nmol.L-1 respectively) and intracellular acidosis (7.11 +/- 0.22 and 7.2 +/- 0.4, respectively) during hypoxia. Cap also decreased [Na+]i in hypoxic myocytes (8.1 +/- 0.9 mmol.L-1). During reoxygenation, Cap decreased [Ca2+]i and [Na+]i but Ena had no significant effect on them. Cap or Ena had no additive effect when combined with verapamil (Ver). CONCLUSION: Cap and Ena protected hypoxic and reoxygenated cardiomyocytes, but the mechanisms were not the same.  (+info)

Fetal tachycardias: management and outcome of 127 consecutive cases. (6/2289)

OBJECTIVE: To review the management and outcome of fetal tachycardia, and to determine the problems encountered with various treatment protocols. STUDY DESIGN: Retrospective analysis. SUBJECTS: 127 consecutive fetuses with a tachycardia presenting between 1980 and 1996 to a single tertiary centre for fetal cardiology. The median gestational age at presentation was 32 weeks (range 18 to 42). RESULTS: 105 fetuses had a supraventricular tachycardia and 22 had atrial flutter. Overall, 52 fetuses were hydropic and 75 non-hydropic. Prenatal control of the tachycardia was achieved in 83% of treated non-hydropic fetuses compared with 66% of the treated hydropic fetuses. Digoxin monotherapy converted most (62%) of the treated non-hydropic fetuses, and 96% survived through the neonatal period. First line drug treatment for hydropic fetuses was more diverse, including digoxin (n = 5), digoxin plus verapamil (n = 14), and flecainide (n = 27). The response rates to these drugs were 20%, 57%, and 59%, respectively, confirming that digoxin monotherapy is a poor choice for the hydropic fetus. Response to flecainide was faster than to the other drugs. Direct fetal treatment was used in four fetuses, of whom two survived. Overall, 73% (n = 38) of the hydropic fetuses survived. Postnatally, 4% of the non-hydropic group had ECG evidence of pre-excitation, compared with 16% of the hydropic group; 57% of non-hydropic fetuses were treated with long term anti-arrhythmics compared with 79% of hydropic fetuses. CONCLUSIONS: Non-hydropic fetuses with tachycardias have a very good prognosis with transplacental treatment. Most arrhythmias associated with fetal hydrops can be controlled with transplacental treatment, but the mortality in this group is 27%. At present, there is no ideal treatment protocol for these fetuses and a large prospective multicentre trial is required to optimise treatment of both hydropic and non-hydropic fetuses.  (+info)

Exercise gas transport determinants in elderly normotensive and hypertensive humans. (7/2289)

This study examined the effect of the phenylalkylamine calcium channel blocker verapamil, on resting left ventricular (LV) function and O2 uptake rate (VO2) during exercise at maximal and submaximal work rates. Nine older hypertensive (71 years; OH), 10 older sedentary normotensive (69 years; OS), 10 older active (71 years; OA) and 10 young (24 years; Y) individuals volunteered. Studies were completed in the control condition and 4-6 h following 240 mg verapamil SR per os. Resting LV systolic (fractional shortening; FS) and diastolic (early: late (E/A) flow velocity ratio and isovolumic relaxation time (IVRT) were measured by Doppler echocardiography. Maximal oxygen uptake (VO2,max) and, on subsequent test days, four transitions to and from a 6 min square wave exercise perturbation at a sub-anaerobic threshold intensity of 40 W (OH, OS, OA) or 100 W (Y) for determination of VO2 kinetics were performed on a cycle ergometer. Breath-by-breath VO2 transients were fitted with a monoexponential equation, starting at phase 2 of the response, while heart rate (HR) was fitted from phase 1, for the determination of the time constant of VO2 (tau VO2) and HR (tau HR). Baseline left ventricular FS was significantly greater in the OS (32%), OA (34%) and Y (34%) than in the OH (23%) groups, while E/A was significantly greater in the OA (1.16) and Y (2.34) than in the OH (0.9) and OS (0.82) groups (P < 0.05). Baseline VO2,max was higher and tau VO2 faster in the young (41.4 ml kg-1 min-1; 25.2 s) than in the older groups and in the OA (28.8 ml kg-1 min-1; 44.3 s) than in both OH (20.8 ml kg-1 min-1; 71.3 s) and OS (22.0 ml kg-1 min-1; 59.5 s) groups (P < 0.05). Heart rate kinetics showed similar differences to VO2 kinetics among the groups. After verapamil, no significant changes in FS, E/A or IVRT were observed in the OA and Y groups. In the OH group, FS (32%) and E/A (1.15) increased while IVRT decreased significantly (from 0.103 to 0.07; P < 0.05). In the OS group, only E/A increased significantly (0.82 to 1.0; P < 0.05). None of the exercise variables (VO2,max, tau VO2 or tau HR) were altered for the OA or Y groups. VO2,max increased (from 20.8 to 22.8 ml kg-1 min-1) in the OH and (from 22.0 to 24.1 ml kg-1 min-1) in the OS (P < 0.05). tau VO2 was accelerated from 71.3 to 49.2 s in the OH group and from 59.5 to 48.2 s in the OS group (P < 0.05). These results suggest that VO2 responses at maximal and submaximal work rates may be dependent upon the initial cardiac pump function of the study population.  (+info)

A region in IVS5 of the human cardiac L-type calcium channel is required for the use-dependent block by phenylalkylamines and benzothiazepines. (8/2289)

Mutations in motif IVS5 and IVS6 of the human cardiac calcium channel were made using homologous residues from the rat brain sodium channel 2a. [3H]PN200-110 and allosteric binding assays revealed that the dihydropyridine and benzothiazepine receptor sites maintained normal coupling in the chimeric mutant channels. Whole cell voltage clamp recording from Xenopus oocytes showed a dramatically slowed inactivation and a complete loss of use-dependent block for mutations in the cytoplasmic connecting link to IVS5 (HHT-5371) and in IVS5 transmembrane segment (HHT-5411) with both diltiazem and verapamil. However, the use-dependent block by isradipine was retained by these two mutants. For mutants HHT-5411 and HHT-5371, the residual current appeared associated with a loss of voltage dependence in the rate of inactivation indicating a destabilization of the inactivated state. Furthermore, both HHT-5371 and -5411 recovered from inactivation significantly faster after drug block than that of the wild type channel. Our data demonstrate that accelerated recovery of HHT-5371 and HHT-5411 decreased accumulation of these channels in inactivation during pulse trains and suggest a close link between inactivation gating of the channel and use-dependent block by phenylalkylamines and benzothiazepines and provide evidence of a role for the transmembrane and cytoplasmic regions of IVS5 in the use-dependent block by diltiazem and verapamil.  (+info)

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TY - JOUR. T1 - Verapamil Concentrations in Cerebrospinal Fluid after Oral Administration. AU - Doran, Allen R.. AU - Narang, Prem K.. AU - Meigs, Cynthia Y.. AU - Wolkowitz, Owen M.. AU - Roy, Alec. AU - Breier, Alan. AU - Pickar, David. PY - 1985/5/9. Y1 - 1985/5/9. N2 - To the Editor: Verapamil, a slow calcium-channel blocker widely used in medical practice, has recently been proposed as a treatment for psychiatric disorders, including depression and manic-depressive illness.1 The foundation for this proposal involves the role of intracellular calcium in the functioning of the neurotransmitter system2 3 4 and the ability of calcium antagonists to block these mechanisms in vitro.5 Despite reports of improvements in symptoms of migraine,6 the occurrence of central nervous system-like side effects, such as perceptual disorders7 and mood changes (Rosing D: personal communication), it is unknown to what extent verapamil is accessible to the central nervous system after.. AB - To the Editor: ...
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Verapamil improves exercise capacity in patients with hypertrophic cardiomyopathy (HCM), but its mechanism of action are unknown. We examined the effects of oral verapamil (320-480 mg/day) on resting left ventricular (LV) systolic and diastolic function in patients with HCM. High-temporal-resolution time-activity curves from gated technetium-99m radionuclide angiograms were analyzed before and after verapamil therapy in 40 patients, of whom 16 were also studied during propranolol therapy (80-960 mg/day). All but one patient had normal or supranormal systolic function, but 70% had evidence of diastolic dysfunction, defined as peak LV filling rate (PFR) less than 2.5 end-diastolic volumes (EDV)/sec or time to PFR greater than 80 msec. Verapamil did not change LV ejection fraction, peak ejection rate or ejection time, but did increase PFR (control 3.3 +/- 1.0 EDV/sec, verapamil 4.1 +/- 1.1 EDV/sec; p less than 0.001) and reduce time to PFR (control 187 +/- 56 msec, verapamil, 159 +/- 34 msec; p ...
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Other Drug Interactions and Additional Drug Interaction Information Colchicine: Colchicine is a substrate for both CYP3A and the efflux transporter, P-gp. Verapamil is known to inhibit CYP3A and P-gp. When verapamil and colchicine are administered together, the potential inhibition of P-gp and/or CYP3A by verapamil may lead to increased exposure to colchicine. (See Section 4.4, Special Warnings and Special Precautions for Use). Antiarrhythmics, beta-blockers: mutual potentiation of cardiovascular effects (higher-grade AV block, higher-grade lowering of heart rate, induction of heart failure and potentiated hypotension). Antihypertensives, diuretics, vasodilators: potentiation of the hypotensive effect. Prazosin, terazosin: additive hypotensive effect. HIV antiviral agents: due to the metabolic inhibitory potential of some of the HIV antiviral agents, such as ritonavir, plasma concentrations of verapamil may increase. Caution should be used or dose of verapamil may be decreased.. Quinidine: ...
Recently, we demonstrated that verapamil, an L-type Ca2+ channel blocker, inhibits the activation of splenic lymphocytes during Walker 256 ascitic tumor development in adult rats. In the present study we have analyzed the changes in spleen size, splenic lymphocyte proliferation, white pulp organization and relative size as well as food intake, and levels of blood haemoglobin in Walker 256 tumor bearing rats. These rats displayed a spleen enlargement associated with a significant increase in white pulp area and TCD8(+) lymphocyte proliferation. Levels of interferon-gamma, but not of interleukin-10, were elevated in tumor bearing rats, indicating a Th1-type immune response. These manifestations were accompanied by reduced food intake and anaemia. Treatment of tumor bearing rats with verapamil avoided spleen enlargement and increased expression of cytokines, as well as the splenic TCD8(+) lymphocyte proliferation. In addition, verapamil treatment promoted an exacerbation of the anorexia, and ...
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Medscape - Hypertension, angina, atrial fibrillation-specific dosing for Calan SR, Isoptin SR, (verapamil), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Detailed Verapamil dosage information for adults, the elderly and children. Includes dosages for Hypertension, Angina Pectoris, Arrhythmias and more; plus renal, liver and dialysis adjustments.. Ways to Increase your Personal Mucus when using Clomid. SteadyS YOUR REACTION. mysql_queryAccess denied for dental localhost (using password: NO). 4 Pictures (question resolved) - Outgrown in: prozac, wellbutrin, verapamil dosage available, side verapamil dosage available, weight - Snip: Hey rebchristopher, Taken at the right Ventured at the right dosages, Wellbutrin with Prozac is a generic combination for depression and anxiety. BupropionWellbutrin Niche Loss Other Bloodshot Effects. Verapamil hydrochloride extended-release tablets USP is a calcium ion influx ...
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Based on a retrospective analysis of the DAVIT II database, we attempted to propose subgroups of post-infarction patients with heart failure, who might benefit or not benefit from antiischemic medical intervention. In DAVIT II, patients were randomized in a double-blind fashion to either verapamil 360 mg/day or placebo in the second week after the infarct and followed up to 18 months. The endpoint was the first major event; that is, death or reinfarction. In patients with heart failure but no ischemia, the event rate was 17.6% in the verapamil-treated patients and 16.5% in the placebo group (hazard verapamil: 1.01; 95% CL: 0.57, 1.79). In patients with both heart failure and residual ischemia, the event rate was 11.3% and 17.8% in the verapamil and placebo groups, respectively (hazard verapamil: 0.60; 95% CL: 0.24, 1.52). Although the latter reduction in major events was not statistically significant, we propose, in accordance with other studies, that in postinfarction patients with both heart ...
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Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Verapamil is used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. Verapamil may also be used for purposes not listed in this medication guide.
Verapamil is only found in individuals that have used or taken this drug. Verapamil is a calcium channel blocker that is a class IV anti-arrhythmia agent. [PubChem]Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thuis reducing heart rate and blood pressure. Verapamils mechanism of effect in cluster headache is thought to be linked to its calcium-channel blocker effect, but which channel subtypes are involved is presently not known. [PubChem] Calcium channel antagonists can be quite toxic. In the management of poisoning, early recognition is critical. Calcium channel antagonists are frequently prescribed, and the potential for serious morbidity and mortality with over dosage is significant. Ingestion of these agents should be suspected in any patient who presents in an overdose situation with unexplained hypotension and conduction abnormalities. The potential for toxicity ...
Hi. Been there, done that. Toprol was horrendous for me also, it MADE my chest hurt which I had no previous problems with, caused coughing, fatigue, I actually saw trees that looked like they had a blue haze around them (visual disturbance). My ex-doctor kept pushing this stuff, until I put my foot down. I then went to verapamil which really helped my migraines, blood pressure. I have no problem taking food with it, actually I have a sensitive stomach and food helps buffer the meds, so its a must for me. Verapamil does cause me to flush a bit, feel warm in chest, neck and face which turn red for awhile. Since the migraines are almost gone, thats most important to me. I do feel a bit tranquilized, but manage to get thru the day and get things done. Im on 240 mg., a day, verapamil ER, in CAPSULE form, I feel that the capsule form also helps with stomach issues. Actually its two 120-mg. capsules, because the 240 mg. capsule is so honking huge, it choked me. Frankly, some sources say verapamil ...
HPLC Application #21417: Verapamil on Lux 5µm Cellulose-4 by SFC. Column used: Lux® 5 µm Cellulose-4, LC Column 250 x 4.6 mm, Ea Part#: 00G-4491-E0
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Author: Allen Loyd V Jr, Year: 2013, Abstract: A formulation for preparing Verapamil Hydrochloride 2.5-mg/mL Injection. Includes ingredients, method of preparation, discussion, and references for the compounding pharmacist.
Verapamil, a calcium channel blocker (Fleckenstein, 1977) used for the treatment of cardiac arrhythmias and hypertension (McTavish and Sorkin, 1989), is given as a racemic mixture. Much is known about the stereoselective disposition of the more potent S- versus R-verapamil in human and rats (Bhatti and Foster, 1997; Busse et al., 2006). Binding of verapamil to bovine serum albumin (BSA) revealed that the unbound plasma fraction of R-verapamil (∼0.65) exceeds that of S-verapamil (∼0.55) (Mehvar and Reynolds, 1996). The reverse is true for binding to human serum albumin and α 1-acid glycoprotein (Mehvar and Reynolds, 1996; Hanada et al., 1998), whereas the plasma bound fraction of verapamil in human is concentration independent within the therapeutic range and unaltered by the presence of norverapamil (Keefe et al., 1981). The distribution of verapamil and norverapamil into red blood cells (RBCs) is also stereoselective [human (S , R) versus rat (R , S)] (Robinson and Mehvar, 1996).. Much ...
TY - JOUR. T1 - Verapamil in a new model of severe local myocardial ischaemia due to combined coronary occlusion and stenosis. AU - Végh, A.. AU - Szekeres, L.. AU - Udvary, Éva. PY - 1987/11/24. Y1 - 1987/11/24. N2 - The effect of verapamil was studied in a new canine model of local myocardial ischaemia. In this model in addition to the critical constriction of the left circumflex coronary artery, the left anterior descending branch was suddenly occluded. Experiments were performed in the anaesthetized, thoracotomized and artificially respired dog. The model represents a severe form of myocardial ischaemia and mimics the clinical situation in which usually more than one coronary artery is involved in the stenotic process. Verapamil (0.15 mg kg -1 i.v.) moderated the extent of the ischaemic changes (indicated by the ST segment elevation in the epicardial and endocardial ECG) as well as their consequences e.g. the incidence and severity of early postocclusion and reperfusion arrhythmias. This ...
Verapamil is class IV anti arrhythmic agent.Verapamil will has a negative inotropic action. Verapamil is useful in treating patient with supraventricular tachycardia , controlling rates in atrial fibrillation, angina pectoris and hypertension.
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September 30, 2017 -- The Global Verapamil Market Professional Survey Report 2017 is a professional and in-depth study on the current state of the Verapamil industry.. Firstly, the report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Verapamil market analysis is provided for the international market including development history, competitive landscape analysis, and major regions development status.. Secondly, development policies and plans are discussed as well as manufacturing processes and cost structures. This report also states import/export, supply and consumption figures as well as cost, price, revenue and gross margin by regions (United States, EU, China and Japan), and other regions can be added.. Then, the report focuses on global major leading industry players with information such as company profiles, product picture and specification, capacity, production, price, cost, revenue and contact information. ...
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Verapamil 180 mg pills, (brand names: Isoptin, Verelan, Calan, Bosoptin), is an L-type calcium channel blocker used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and most recently, headaches. Not to be used along with beta-blockers. Class 4 antiarrhythmic, more effective than digoxin in controlling ventricular rate. Approved by FDA in 1981. One of its purified isomers does not cause constipation whereas racemic Verapamil does. Used as a vasodilator during cryopreservation of blood vessels. - Stock Image C003/0154
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After coronary occlusion, myocardium originally supplied by the occluded vessel ultimately separates into infarct and surviving muscle. To clarify this process, evolution of collateral blood flow to infarct and to surviving myocardium was retrospectively analyzed after permanent left anterior descending occlusion in 24 closed chest dogs. Microspheres were injected before occlusion and 5 and 20 minutes and 4 hours after occlusion. Ten minutes after occlusion, dogs received either verapamil, 0.4 mg/kg, followed by 0.6 mg/kg per hour for 6 hours (n = 10) or equivalent saline solution (n = 14). These dogs were sacrificed 3 days later, the distribution of the occluded artery was defined by dye perfusion and infarcted myocardium was determined by triphenyltetrazolium staining of heart slices. Surviving muscle within the distribution of the occluded artery was divided into medial regions adjacent to the infarct (medial adjacent) and remote from the infarct (medial remote) and lateral regions adjacent ...
Alcoholic depression of left ventricular function was produced in normal hamsters by the administration of increasing concentrations of alcohol in drinking water (up to 50%) for 6 months. The result was assessed by phosphorus-31 nuclear magnetic resonance of isolated perfused hearts and high-pressure liquid chromatography of freeze-clamped tissues. Hemodynamic data and myocardial oxygen consumption were also monitored. Alcoholic hamsters had significantly higher inorganic phosphate and lower ATP levels, while maintaining normal intracellular pH, phosphocreatine, and creatine. Although coronary flow and oxygen consumption were maintained at normal levels, hamsters ingesting 50% ethanol had significantly lower left ventricular developed pressure and dP/dt. Treatment with verapamil during long-term ethanol consumption prevented the development of these metabolic and functional abnormalities. It is hypothesized that alcohol produces membrane abnormalities leading to adverse ion flux, and that these ...
The investigators have demonstrated previously that the calcium channel antagonists (CCAs) verapamil, nifedipine, and diltiazem can block in vitro and in vivo meningioma growth at clinically relevant doses (Jensen, Lee et al. 1995; Jensen, Petr et al. 2000; Jensen and Wurster 2001). However, only modest growth inhibition was exhibited in the tumors in these studies with CCAs alone. Many authors have shown augmented growth inhibition by adding CCAs to traditional chemotherapies in other tumor types (Tsuruo, Iida et al. 1981; Tsuruo, Iida et al. 1983; Helson 1984; Robinson, Clutterbuck et al. 1985; Ince, Appleton et al. 1986; Merry, Fetherston et al. 1986; Cano-Gauci and Riordan 1987). For instance, the combination of verapamil and 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) is better than BCNU alone in inhibiting the growth of human gliomas in vitro and in vivo (Bowles, Pantazis et al. 1990). Calcium antagonists seem to exert the majority of their anti-tumor effects by inhibiting calcium ...
Verapamil is a potent calcium antagonist known to inhibit excitation-contraction coupling in both myocardium and myometrium. Its effect upon glucose- and sulfonylurea-induced insulin release was investigated in the isolated perfused rat pancreas.. After twenty-five minutes pretreatment and at concentrations ranging between 0.8 and 8.1 μM, verapamil caused a dose-related inhibition of glucose-induced insulin release during both the early and late phase of the secretory process. At a concentration of 0.8 μM, the degree of inhibition was more marked when the exposure time to verapamil prior to stimulation with glucose was increased to sixty minutes. Verapamil also inhibited gliclazide-induced insulin release. Infusion of verapamil during the late phase of the secretory response to glucose demonstrated that the inhibition of insulin release was an immediate and reversible phenomenon. The inhibitory effect of verapamil was enhanced at a subnormal calcium concentration and reduced at a high calcium ...
Verapamil HCl is a calcium channel blocker administered on thrice a day dosage regimen. In the present study resinates of verapamil HCl were formulate..
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Has anyone had this happen - I am on verapmil and maxzide daily - iv been doing alright, b.p wise but the past few days iv been getting some rapid heart beats here and there. and cramping bad and ank...
Generic Isoptin (Verapamil) is in a group of drugs called calcium channel blockers. Generic Isoptin offers highly effective treatment of numerous symptoms and is one of the top prescribed medicatio...
Riva-Verapamil SR: Verapamil belongs to the class of medications called calcium channel blockers. The sustained release (SR) form of this medication is used for the treatment of mild-to-moderate high blood pressure, when beta-blockers or diuretics (water pills) are not recommended or have caused unacceptable side effects. The immediate-release form of verapamil may be used to treat certain abnormal heart rhythms, angina (chest pain) and certain conditions where the heart muscle is enlarged, as well as blood pressure. It works to control blood pressure and reduce the number of angina attacks by relaxing blood vessels. It also helps to normalize heart rhythms.
verapamil) and benzothiazepines; both of which are well known calcium channel blockers. These sites on the alpha-1 subunit ... The effects of AH-1058 are slower to onset but longer-lasting than those of verapamil and atenolol. In addition, the minimal ... Lastly AH-1058 displays a greater selectivity for cardiac tissue over verapamil and atenolol with the same level of potency as ... Studies have compared AH-1058 to widely used and clinically available drugs such as verapamil (a Class IV antiarrhythmic drug) ...
Fendiline Gallopamil Verapamil (Calan, Isoptin) Thymoquinone from Black seed (Nigella sativa) is a calcium channel blocker. ... Caution should be taken when using verapamil with a beta blocker due to the risk of severe bradycardia. If unsuccessful, ... ACE inhibitor Angiotensin II receptor antagonist Nitrate Tfelt-Hansen, P; Tfelt-Hansen, J (2009). "Verapamil for cluster ...
Verapamil, a calcium-channel blocker, is useful in the treatment of hypomania and in those cases where lithium and mood ... Verapamil is effective for both short-term and long-term treatment. Antidepressant monotherapy is not recommended for the ... Giannini AJ, Houser WL, Loiselle RH, Giannini MC, Price WA (1984). "Antimanic effects of verapamil". American Journal of ... Giannini AJ, Taraszewski R, Loiselle RH (1987). "Verapamil and lithium in maintenance therapy of manic patients". Journal of ...
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A comparison with verapamil and diltiazem". Arzneimittel-Forschung. 32 (9): 1056-9. PMID 6890826. Yoshino, K.; Kohno, T.; Uno, ...
Class IV agents include verapamil and diltiazem. Since the development of the original Vaughan Williams classification system, ...
... and verapamil 0.2. Felodipine is a member of the 1,4-dihydropyridine class of calcium channel blockers. It is a racemic mixture ... verapamil, nicardipine, and isradipine. The FDA gave the drug a 1C rating, meaning that it found little difference between ...
Verapamil is recommended as first line treatment. Lithium can also be useful. For people with shorter bouts, a short course of ...
The calcium channel blocker verapamil is reported to be useful in alleviating symptoms (lower frequency and duration of attacks ... Narbone MC, Gangemi S, Abbate M (June 2005). "A case of SUNCT syndrome responsive to verapamil". Cephalalgia. 25 (6): 476-8. ...
"Is Intralesional Verapamil Effective Therapy for Peyronie's Disease?" Journal of Urology, July 2012. "Confocal Fluorescence ...
The recommended first-line preventive therapy is verapamil, a calcium channel blocker. Verapamil was previously underused in ... Measures recommended to decrease the frequency of attacks include steroid injections, civamide, or verapamil. Nerve stimulation ...
Medications to treat CPVT include beta blockers and verapamil. Flecainide inhibits the release of the cardiac ryanodine ...
Use of ivabradine with verapamil or diltiazem is contraindicated. Overall, 14.5% of patients taking ivabradine experience ...
Non-dihydropyridine calcium channels blockers such as diltiazem and verapamil are preferable, as dihydropyridine agents such as ... "Alleviation of cocaine-induced coronary vasoconstriction with intravenous verapamil". The American Journal of Cardiology. 73 (7 ...
Medications that may be used include lamotrigine, acetazolamide, or verapamil. But these do not always result in benefits. ... or verapamil. But these do not always result in benefits. Some neuro-ophthalmologists believe that visual snow is not a medical ...
"Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors". Circulation. 97 (13): 1227-30. PMID 9570190. ...
Pollak, A; Falk, R H (1993-08-01). "Left ventricular systolic dysfunction precipitated by verapamil in cardiac amyloidosis". ...
Lazarova M, Petkova B, Staneva-Stoycheva D (December 1999). "Effects of the calcium antagonists verapamil and nitrendipine on ...
"Adenosine vs Verapamil (calcium channel blocker) in the acute treatment of supraventricular tachycardias". Archived from the ... If unsuccessful or the PSVT recurs diltiazem or verapamil are recommended. Adenosine may be safely used during pregnancy. SVT ...
... verapamil, other calcium channel blockers, and beta blockers. They can exacerbate the syndrome by blocking the heart's normal ...
Other CYP3A4 inhibitors including erythromycin, saquinavir, and verapamil should be used with caution. Other drugs that ...
Arsura E, Lefkin AS, Scher DL, Solar M, Tessler S (1987). "A randomized, double-blind, placebo-controlled study of verapamil ... Salerno DM; Anderson B; Sharkey, Iber C (1987). "Intravenous Verapamil for Treatment of Multifocal Atrial Tachycardia with and ... the rate may in some cases be reduced by administering the calcium channel blocker verapamil or the beta blocker metoprolol. ...
Radioactive verapamil can be used for measuring P-gp function with positron emission tomography. P-gp is also used to ... tamoxifen and verapamil. Decreased P-gp expression has been found in Alzheimer's disease brains. Altered P-gp function has also ... and Verapamil. At transcriptional level, the expression of P-gp has been intensively studied, and numerous transcriptional ... verapamil for measuring P-glycoprotein function with positron emission tomography". Journal of Labelled Compounds & ...
Their mechanism is similar to drugs such as verapamil, although taxines are more cardioselective. They also reduce the rate of ... Tekol Y; Göğüsten B. "Comparative determination of the cardioselectivity of taxine and verapamil in the isolated aorta, atrium ...
DAPPI can analyze both polar (e.g. verapamil) and nonpolar (e.g. anthracene) compounds. This technique has an upper detection ...
... 's class IV activity is similar to that of its parent drug, verapamil. The drug targets L-type Ca+2 channels, and ... Being a derivative of verapamil, it possesses the ability to inhibit Ca+2 membrane channels. Specific modifications in hydrogen ...
Some of these calcium antagonists include verapamil, diltiazem, amlodipine, benidipine, cilnidipine, nicardipine, and ...
... is an analog of the more common drug verapamil, which is the most common type of phenylalkylamine style calcium ... It is able to do this by bonding to the myocardium tighter then verapamil. Raddino, Riccardo; Poli, Enzo; Pasini, Evasio; ... Pugsley, M.K. "Effects of anipamil, a long acting analog of verapamil, in pigs subjected to myocardial ischemia". Life Sciences ... Anipamil has been shown to be a more effective antiarrhythmic medication than verapamil because it does not cause hypertension ...
Paterna, S; Martino, SG; Campisi, D; Cascio Ingurgio, N; Marsala, BA (1990). "Evaluation of the effects of verapamil, ... Myocardial bridge For supraventricular tachycardias (PSVT), diltiazem appears to be as effective as verapamil in treating re- ... Its pharmacological activity is somewhat similar to verapamil, another nondihydropyridine (non-DHP) calcium channel blocker. ...
... (INN) is an L-type calcium channel blocker that is an analog of verapamil. It is used in the treatment of cardiac ... Sewing K-F, Hannemann H (1983). "Calcium Channel Antagonists Verapamil and Gallopamil Are Powerful Inhibitors of Acid Secretion ...
I am wondering if anyone here has tried Verapamil (calcium channel blocker) and what the success and side effects have been for ... I am moving in a couple of months and I am figuring that if the Verapamil doesnt work, or also gives me bad side effects, Im ... This brings me to today-my GP told me to try Verapamil, which I am skeptical about because since it too lowers blood pressure, ... I am wondering if anyone here has tried Verapamil (calcium channel blocker) and what the success and side effects have been for ...
A list of US medications equivalent to Verapamil RK is available on the Drugs.com website. ... Verapamil RK is a medicine available in a number of countries worldwide. ... Verapamil. Verapamil hydrochloride (a derivative of Verapamil) is reported as an ingredient of Verapamil RK in the following ... Verapamil RK. Verapamil RK may be available in the countries listed below. ...
Verapamil is new to me. (I was on 300mg of Topamax.) I will only take pills at night, cause all these scrips make me tired and ... I too take verapamil and they just increased my topomax to twice a day. I hate taking medication and take it at night also ... This time 400mg of Topamax & 180mg of Verapamil. I hate meds & I hate to complain & I hate to be in pain just like you.. This ... Anyone have any experience with Verapamil (which I know is for high blood pressure) or Maxalt? Thanx everyone. kim ...
Verapamil does cause me to flush a bit, feel warm in chest, neck and face which turn red for awhile. Since the migraines are ... Verapamil.. Doc put me on low dose Maxzide dieretic med. that counter acts the ankle thing.. but it took days to stop that ! Im ... as I have taken this drug before, and was switched off a nasty beta blocker Toprol xl -and put on verapamil - about 3months ago ... Im on 240 mg., a day, verapamil ER, in CAPSULE form, I feel that the capsule form also helps with stomach issues. Actually ...
reaction while on verapamil and maxzide ???. Has anyone had this happen - I am on verapmil and maxzide daily - iv been doing ... this drug and asprin interacts with Verapamil - I had all the side effects of it ! Cant trust eatting out anymore !! filed ... this drug and asprin interacts with Verapamil - I had all the side effects of it ! Cant trust eatting out anymore !! filed ...
Verapamil Hydrochloride) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and ... R verapamil is 94% bound to plasma albumin, while S verapamil is 88% bound. In addition, R verapamil is 92% and S verapamil 86 ... Verapamil is a calcium ion influx inhibitor (L-type calcium channel blocker or calcium channel antagonist). Verapamil exerts ... Verapamil HCl is not structurally related to other cardioactive drugs. In addition to verapamil HCl the Verelan PM capsule ...
Verapamil is a prescription calcium-channel blocker. If your doctor prescribes it, its important to provide your doctor and ... Verapamil Side Effects. Verapamil is used to control chest pain called angina as well as high blood pressure. It may be used ... While verapamil does not appear to have a high risk of interacting with normal doses of vitamin D, it does interact with other ... Verapamil also slows electrical activity in your heart, which helps control heart rate, and increases the supply of oxygen and ...
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One of its purified isomers does not cause constipation whereas racemic Verapamil does. Used as a vasodilator during ... Verapamil 180 mg pills, (brand names: Isoptin, Verelan, Calan, Bosoptin), is an L-type calcium channel blocker used in the ... Caption: Verapamil 180 mg pills, (brand names: Isoptin, Verelan, Calan, Bosoptin), is an L-type calcium channel blocker used in ... One of its purified isomers does not cause constipation whereas racemic Verapamil does. Used as a vasodilator during ...
Verapamil is used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. ... Verapamil may also be used for purposes not listed in this medication guide. ... Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. ... What is the most important information I should know about verapamil?. You should not use verapamil if you have a serious heart ...
Drug: Verapamil Verapamil is another commonly used medication. It is used for the treatment of angina, hypertension, ... Verapamil sustained release tablets will begin at a dose of 120 mg each day for two weeks, then 240 mg each day for two weeks, ... Dosing with standard verapamil is 80-120 mg pox three times a day but the sustained release form can be given 120-480mg once or ... Dosing with standard verapamil is 80-120 mg pox three times a day but the sustained release form can be given 120-480mg once or ...
A formulation for preparing Verapamil Hydrochloride 2.5-mg/mL Injection. Includes ingredients, method of preparation, ... Verapamil Hydrochloride 2.5-mg/mL Injection. Allen Loyd V Jr Mar/Apr 2013. 153. Buy. ... Abstract: A formulation for preparing Verapamil Hydrochloride 2.5-mg/mL Injection. Includes ingredients, method of preparation ... Related Keywords: Loyd V. Allen Jr., PhD, RPh, verapamil, calcium-channel blocker, coronary vasodilator, dysrhythmia, ...
Verapamil also inhibited gliclazide-induced insulin release. Infusion of verapamil during the late phase of the secretory ... Verapamil is a potent calcium antagonist known to inhibit excitation-contraction coupling in both myocardium and myometrium. ... At a concentration of 0.8 μM, the degree of inhibition was more marked when the exposure time to verapamil prior to stimulation ... After twenty-five minutes pretreatment and at concentrations ranging between 0.8 and 8.1 μM, verapamil caused a dose-related ...
... verapamil 4.1 +/- 1.1 EDV/sec; p less than 0.001) and reduce time to PFR (control 187 +/- 56 msec, verapamil, 159 +/- 34 msec; ... Verapamil did not change LV ejection fraction, peak ejection rate or ejection time, but did increase PFR (control 3.3 +/- 1.0 ... Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy. ... Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy. ...
Has a generic version of VERAPAMIL HYDROCHLORIDE been approved? Find suppliers, manufacturers, and packagers ... VERAPAMIL HYDROCHLORIDE. verapamil hydrochloride. CAPSULE, EXTENDED RELEASE;ORAL. 078306. ANDA. Physicians Total Care, Inc.. ... VERAPAMIL HYDROCHLORIDE. verapamil hydrochloride. CAPSULE, EXTENDED RELEASE;ORAL. 078306. ANDA. Physicians Total Care, Inc.. ... VERAPAMIL HYDROCHLORIDE. verapamil hydrochloride. CAPSULE, EXTENDED RELEASE;ORAL. 078306. ANDA. Physicians Total Care, Inc.. ...
Oral Verapamil has no Effect on Glucose Tolerance in Non-Diabetics. C.G. Semple, J.A. Thomson, C.D. Forbes, G.H. Beastall, A.R. ... Oral Verapamil has no Effect on Glucose Tolerance in Non-Diabetics. C.G. Semple, J.A. Thomson, C.D. Forbes, G.H. Beastall, A.R. ... Oral Verapamil has no Effect on Glucose Tolerance in Non-Diabetics Message Subject (Your Name) has forwarded a page to you from ...
Verapamil Hydrochloride (CAS 36622-29-4), an isomer that inhibits the p-glycoprotein efflux pump in MDR tumor cell lines, from ... S)-(-)-Verapamil Hydrochloride inhibit p-glycoprotein efflux pump in multidrug resistant tumor cells. (S)-(-)-Verapamil ... S)-(-)-Verapamil HydrochlorideCAS: 36622-29-4. MF: C27H39ClN2O4. MW: 491.06. An isomer that inhibits the p-glycoprotein efflux ... S)-(-)-Verapamil Hydrochloride (CAS 36622-29-4) *bvseo_sdk, java_sdk, bvseo-3.2.0 ...
Verapamil on Lux 5µm Cellulose-4 by SFC. Column used: Lux® 5 µm Cellulose-4, LC Column 250 x 4.6 mm, Ea Part#: 00G-4491-E0 ...
Treatment with verapamil during long-term ethanol consumption prevented the development of these metabolic and functional ... The preventive effect of verapamil on ethanol-induced cardiac depression: phosphorus-31 nuclear magnetic resonance and high- ... The preventive effect of verapamil on ethanol-induced cardiac depression: phosphorus-31 nuclear magnetic resonance and high- ... The preventive effect of verapamil on ethanol-induced cardiac depression: phosphorus-31 nuclear magnetic resonance and high- ...
Find details on Verapamil. Medication for cats including uses, administration, pharmacokinetics, precautions, adverse reactions ... Verapamil may displace these Warfarin from plasma proteins.. Vincristine. *Verapamil may increase intracellular vincristine ... Effects enhanced by verapamil.. Cimetidine. *Cimetidine Cimetidine inhibits the metabolism of verapamil increasing plasma ... Digoxin Digoxin and digitoxin Digitoxin plasma concentrations are increased by verapamil Verapamil. ...
Verapamil is used to treat the condition cluster headache. Use of verapamil is generally avoided in people with severe left ... Verapamil is sold under many trade names worldwide. Gallopamil Tiapamil "Verapamil - Drugs.com". www.drugs.com. Archived from ... 1637-9. "DailyMed - VERAPAMIL HYDROCHLORIDE - verapamil hydrochloride tablet". dailymed.nlm.nih.gov. Archived from the original ... and hypersensitivity to verapamil. The most common side effect of Verapamil is constipation (7.3%). Other side effects include ...
Tarka is the brand name of an oral antihypertensive medication that combines a slow release formulation of verapamil ... Trandolapril- Verapamil (Tarka) Drug Information - Indications, Dosage, Side Effects and Precautions , Medindia http://www. ... medindia.net/doctors/drug_information/trandolapril_verapamil.htm#ixzz28Q6od52B. ...
Verapamil: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Take verapamil at around the same time(s) every day. Certain verapamil products should be taken in the morning and others at ... Before taking verapamil,. *tell your doctor and pharmacist if you are allergic to verapamil, any other medications, or any ... Continue to take verapamil even if you feel well. Do not stop taking verapamil without talking to your doctor. ...
Verapamil is also available without a brand name, ie as the generic medicine.) ... Zolvera oral solution contains the active ingredient verapamil, which is a type of medicine called a calcium-channel blocker. ... Zolvera (verapamil). Zolvera oral solution contains the active ingredient verapamil, which is a type of medicine called a ... By depriving them of calcium, verapamil causes the muscle cells to relax. This action of verapamil has two main effects; it ...
Verapamil is also available without a brand name, ie as the generic medicine.) ... Verapress MR tablets contain the active ingredient verapamil, which is a type of medicine called a calcium-channel blocker. ... Verapress MR (verapamil). Verapress MR tablets contain the active ingredient verapamil, which is a type of medicine called a ... By depriving them of calcium, verapamil causes the muscle cells to relax. This action of verapamil has two main effects; it ...
Trandolapril and Verapamil: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Trandolapril and verapamil may cause an upset stomach. Take trandolapril and verapamil with food or milk.Talk to your doctor ... Continue to take trandolapril and verapamil even if you feel well. Do not stop taking trandolapril and verapamil without ... Before taking trandolapril and verapamil,. *tell your doctor and pharmacist if you are allergic to trandolapril, verapamil, ...
Verapamil is an oral medication used to treat high blood pressure. Learn who its for, how it works, its side effects, warnings ... What is verapamil?. Verapamil oral capsule is a prescription medication thats available as the brand-name drugs Verelan PM ( ... Verapamil extended-release forms are used to lower your blood pressure.. How it works. Verapamil is a calcium channel blocker. ... How to take verapamil. This dosage information is for verapamil oral capsules and oral tablets. All possible dosages and forms ...
Verapamil is a calcium blocker that may work by preventing the constriction of the blood vessels prior to the migraine attack. ... Verapamil. Posted at 19:14h in Headache Fact Sheets by headache 1 Comment ... Verapamil is commonly used for blood pressure and heart conditions. It takes at least four to six weeks for it to become ... Verapamil is a calcium blocker that may work by preventing the constriction of the blood vessels prior to the migraine attack. ...
Prescriber Checkup » VERAPAMIL HCL VERAPAMIL HCL. Verapamil is used to treat high blood pressure and to control angina (chest ... Top prescribers for VERAPAMIL HCL. 1 2 3 4 5 … Next › Last » ...
verapamil HCl 180 MG Extended Release Oral Tablet. PSN. 2. 897640. verapamil hydrochloride 180 MG Extended Release Oral Tablet ... verapamil HCl 240 MG Extended Release Oral Tablet. PSN. 4. 897649. verapamil hydrochloride 240 MG Extended Release Oral Tablet ... Plasma S-(-) verapamil Cmax and AUC were both increased 50%. Co-administration of verapamil with everolimus in 16 healthy ... Verapamil is excreted in human milk. Because of the potential for adverse reactions in nursing infants from verapamil, nursing ...
Cyclosporine: Verapamil therapy may increase serum levels of cyclosporine. Theophylline: Verapamil may inhibit the clearance ... Plasma S-(-) verapamil C max and AUC were both increased 50%. Co-administration of verapamil with everolimus in 16 healthy ... Verapamil is excreted in human milk. Because of the potential for adverse reactions in nursing infants from verapamil, nursing ... Verapamil hydrochloride (verapamil HCl) tablets, USP is a calcium ion influx inhibitor (slow-channel blocker or calcium ion ...
VERAPAMIL. THE USE OF VERAPAMIL IN INFANTS IS CONTROVERSIAL. THE POSSIBILITY OF IRREVERSIBLE SIDE EFFECTS (PROFOUND BRADYCARDIA ... VERAPAMIL Disclaimer to the On-line Edition. This Manual has been designed for use in the NICU at London Health Sciences Centre ...
Testing Status of Verapamil M20409. CASRN: 52-53-9. Formula: C27-H38-N2-O4. Synonyms/Common Names. *Benzeneacetonitrile, alpha ...
Goligorsky M.S., Chaimovitz C., Shany S., Rapoport J., Sharony Y. (1984) Verapamil Improves Defective Intestinal Calcium ...
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
Verapamil Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS ... Verapamil and norverapamil distribute into the CNS.115 117 118 207. Verapamil crosses the placenta and is present in umbilical ... Intravenous verapamil infusion. Hosp Pharm. 1986; 21:463-4.. 157. Barbarash RA, Bauman JL, Lukazewski AA et al. Verapamil ... Verapamil. Bethesda, MD: American Society of Health-System Pharmacists; 2018 .. c. Searle. Covera-HS(verapamil hydrochloride) ...
Find the most comprehensive real-world treatment information on Verapamil at PatientsLikeMe. 258 patients with fibromyalgia, ... bipolar I disorder or psoriasis currently take Verapamil. ... Verapamil does not seem to effect me in any negative way. * 0 ... Showing 3 of 10 patient evaluations for Verapamil Previous page 1 2 3 4 Next page ...
Verapamil is used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. ... Verapamil may also be used for purposes not listed in this medication guide. ... Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. ... What is the most important information I should know about verapamil?. You should not use verapamil if you have a serious heart ...
Serious verapamil poisoning: treatment with intravenous calcium gluconate. Br Med J 1978; 2 :1127 ... Serious verapamil poisoning: treatment with intravenous calcium gluconate.. Br Med J 1978; 2 doi: https://doi.org/10.1136/bmj. ...
Find patient medical information for Verapamil Oral on WebMD including its uses, side effects and safety, interactions, ... Verapamil may also lower your heart rate.. How to use Verapamil ER Capsule, Extended Release Pellets 24 Hr. Take this ... Other medications can affect the removal of verapamil from your body, which may affect how verapamil works. Examples include ... verapamil ER (PM) 300 mg capsule 24hr pellet CT,ext.release. color. red. shape. oblong. imprint. MYLAN 6203, MYLAN 6203. This ...
Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. You should not use this medicine together with sacubitril. Do not use this medicine and sacubitril/valsartan (Entresto®) within 36 hours of each other. Do not use this medicine at least 2 weeks before or 2 days after using flibanserin. Using these medicines together may cause serious unwanted effects. This medicine may worsen the condition of patients with heart disease or heart rhythm problems. Check with your doctor right away if you have chest pain or tightness, decreased urine output, dilated neck veins, extreme fatigue, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, troubled breathing, or weight gain. You might also feel dizzy or faint, or you might have a fast, pounding, or uneven ...
Verapamil Hydrochloride) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and ... Verapamil HCl is not structurally related to other cardioactive drugs.. In addition to verapamil HCl the Verelan capsule ... Verapamil is excreted in human milk. Because of the potential for adverse reactions in nursing infants from verapamil, nursing ... verapamil hydrochloride) Capsules. DESCRIPTION. Verelan® (verapamil hydrochloride capsules) is a calcium ion influx inhibitor ( ...
Just got verapamil today. What can I expect?. I would like to hear the good bad and the ugly. ...
  • Verelan® PM (verapamil hydrochloride extended-release capsules) for oral use is indicated for the treatment of hypertension , to lower blood pressure. (rxlist.com)
  • S)-(-)-Verapamil Hydrochloride inhibit p-glycoprotein efflux pump in multidrug resistant tumor cells. (scbt.com)
  • S)-(-)-Verapamil Hydrochloride is an inhibitor of AR. (scbt.com)
  • Verapamil is a hydrochloride. (healthery.com)
  • I too take verapamil and they just increased my topomax to twice a day. (dailystrength.org)
  • There is a theoretical risk that hypercalcemia caused by excess vitamin D intake can precipitate a cardiac arrhythmia if you take verapamil, according to "Herb, Nutrient and Drug Interactions," by Mitchell Bebel Stargrove, et al. (livestrong.com)
  • The investigators have demonstrated previously that the calcium channel antagonists (CCAs) verapamil, nifedipine, and diltiazem can block in vitro and in vivo meningioma growth at clinically relevant doses (Jensen, Lee et al. (clinicaltrials.gov)
  • Furthermore, the investigators have more recently demonstrated that the addition of a verapamil or diltiazem with HU enhances the growth inhibition seen with these drugs in vitro and in vivo. (clinicaltrials.gov)
  • Verapamil is used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. (peacehealth.org)
  • In DAVIT II, patients were randomized in a double-blind fashion to either verapamil 360 mg/day or placebo in the second week after the infarct and followed up to 18 months. (forskningsdatabasen.dk)
  • Verapamil is used to control chest pain called angina as well as high blood pressure. (livestrong.com)
  • Digoxin Digoxin and digitoxin Digitoxin plasma concentrations are increased by verapamil Verapamil . (vetstream.com)
  • Cimetidine Cimetidine inhibits the metabolism of verapamil increasing plasma concentrations. (vetstream.com)
  • I am wondering if anyone here has tried Verapamil (calcium channel blocker) and what the success and side effects have been for you. (healingwell.com)
  • This brings me to today-my GP told me to try Verapamil, which I am skeptical about because since it too lowers blood pressure, I'm expecting similar side effects as the propranolol. (healingwell.com)
  • I am moving in a couple of months and I am figuring that if the Verapamil doesn't work, or also gives me bad side effects, I'm going to start fresh by seeing a neurologist in my new city. (healingwell.com)
  • What are the possible side effects of verapamil? (rxlist.com)
  • Both vitamin D2 and verapamil can cause side effects. (livestrong.com)
  • Verapamil side effects may include constipation, heartburn, dizziness or headaches. (livestrong.com)
  • 5 Despite reports of improvements in symptoms of migraine, 6 the occurrence of central nervous system-like side effects, such as perceptual disorders 7 and mood changes (Rosing D: personal communication), it is unknown to what extent verapamil is accessible to the central nervous system after. (elsevier.com)
  • Verapamil and migraine, long term side effects verapamil. (pillsrxbest.com)
  • The most common side effect from Verapamil is constipation. (healthery.com)
  • Editorial Verapamil sr 120 mg tab Investigation February 29, 2016. (pillsrxbest.com)
  • I'm on 240 mg., a day, verapamil ER, in CAPSULE form, I feel that the capsule form also helps with stomach issues. (medhelp.org)
  • However, Verapamil doesn't stop chest pain when it's already occurring. (healthery.com)
  • Dosing with standard verapamil is 80-120 mg pox three times a day but the sustained release form can be given 120-480mg once or twice each day. (clinicaltrials.gov)
  • Verapamil enhances the effect of theophylline Theophylline possibly leading to toxicity. (vetstream.com)
  • Verapamil is administered as a racemic mixture of the R and S enantiomers. (rxlist.com)
  • Verapamil may displace these Warfarin from plasma proteins. (vetstream.com)
  • The usual daily dose of sustained-release verapamil, Verelan, in clinical trials has been 240 mg given by mouth once daily in the morning. (rxlist.com)
  • as light blue, capsule shaped, bevelled edged, scored, film coated tablets containing 180 mg of verapamil hydrochloride USP. (nih.gov)
  • Calcium channel blockers like verapamil dilate blood vessels, which increases the supply of blood and oxygen to the heart. (wikipedia.org)
  • Verapamil works by slowing down the movement of calcium through muscle cells that are found in the heart and the walls of blood vessels. (netdoctor.co.uk)
  • Verapamil relaxes your blood vessels, which can reduce the amount of work your heart has to do. (healthline.com)
  • Verapamil is a calcium blocker that may work by preventing the constriction of the blood vessels prior to the migraine attack. (headaches.org)
  • Verapamil has also been used as a vasodilator during cryopreservation of blood vessels. (thefullwiki.org)
  • Verapamil belongs to a group of drugs called calcium channel blockers, which work by relaxing the blood vessels, making it easier for the heart to pump blood. (rxwiki.com)
  • Your doctor will probably start you on a low dose of verapamil and gradually increase your dose. (medlineplus.gov)
  • Twenty-two patients with hypertrophic obstructive cardiomyopathy were treated with the calcium inhibitor, verapamil, which was administered in a mean oral dose of 480 mg per day. (bmj.com)
  • For most conditions, the dose of verapamil for adults is 80 mg to 120 mg taken 3 or 4 times daily with food. (medbroadcast.com)
  • When treating specific conditions where the heart muscle is enlarged and preventing the heart from working efficiently, the dose may be increased to 600 mg or 720 mg of verapamil divided throughout the day. (medbroadcast.com)
  • If you use the sustained-release (SR) tablets , the recommended dose of verapamil ranges from 180 mg to 480 mg daily with food. (medbroadcast.com)
  • To test their theories about the presence of P-glycoprotein overexpression in the nasal lining of patients who have CRS with nasal polyp, study authors conducted a randomized, double-blind, placebo-controlled clinical trial studying the use of low-dose verapamil in 18 patients with CRS with nasal polyps. (uspharmacist.com)
  • The treatment effect was significantly limited among patients with higher body mass indices, however, and study authors say that future studies are being planned to determine if a higher dose of verapamil may be needed to be therapeutic for some patients. (uspharmacist.com)
  • Researchers monitored the placebo and verapamil groups' total daily dose of insulin, the amount of insulin produced, the percent change in insulin production, and their HbA1C levels. (eurekalert.org)
  • After twenty-five minutes' pretreatment and at concentrations ranging between 0.8 and 8.1 μM, verapamil caused a dose-related inhibition of glucose-induced insulin release during both the early and late phase of the secretory process. (diabetesjournals.org)
  • A 39-year-old woman with chronic hypertension took 17 tablets of extended-release verapamil, 240 mg (total dose, 4.08 g), at 1:00 a.m. (annals.org)
  • What if you miss a dose of Verapamil? (internationaldrugmart.com)
  • They conducted a randomized, double-blind, placebo-controlled trial with low-dose verapamil in 18 patients with CRS with nasal polyps. (empr.com)
  • Motivated by their previous finding of the presence of P-glycoprotein overexpression in the nasal lining of patients with CRS with nasal polyps, the study authors conducted a randomized, double-blind, placebo-controlled clinical trial studying the use of low-dose Verapamil in 18 patients with CRS with nasal polyps. (physiciansweekly.com)
  • Future studies are being planned to determine if a higher dose of Verapamil may be needed to be therapeutic for some patients. (physiciansweekly.com)
  • The drug-resistant cell line 8226/DOX40 is known to have reduced intracellular drug accumulation associated with the overexpression of P-glycoprotein when compared to the sensitive parent cell line 8226/S. Verapamil alone was minimally cytotoxic in both cell lines, but reversed doxorubicin resistance in a dose-related manner in 8226/DOX40. (aacrjournals.org)
  • A similar dose-response relationship was observed for verapamil in increasing net intracellular doxorubicin accumulation. (aacrjournals.org)
  • No correlation was found between the change in hemodynamic parameters and the total dose of verapamil. (thejns.org)
  • This study indicates that high-dose intraarterial verapamil may be used to treat cerebral vasospasm without compromising hemodynamic stability or increasing ICP. (thejns.org)
  • Trandolapril with verapamil sustained release (SR) in a fixed-dose combination tablet (Tarka) will be listed on the PBS on 1 May 2007. (nps.org.au)
  • A previous trial of oral Verapamil showed preliminary efficacy for the treatment of CRSwNP. (clinicaltrials.gov)
  • To characterize the hemodynamic response to exercise and the effects of calcium channel antagonism in hypertensive subjects, invasive exercise hemodynamics were performed in the baseline state after intravenous infusion of verapamil and after 5 to 7 days of oral verapamil in 10 subjects with moderate to severe hypertension. (ahajournals.org)
  • We examined the effects of oral verapamil (320-480 mg/day) on resting left ventricular (LV) systolic and diastolic function in patients with HCM. (ahajournals.org)
  • Verapamil oral capsule is a prescription medication that's available as the brand-name drugs Verelan PM (extended-release) and Verelan (delayed-release). (healthline.com)
  • Verelan (verapamil HCl) is indicated for the treatment of hypertension , to lower blood pressure. (rxlist.com)
  • The Verelan PM formulation has been designed to initiate the release of verapamil 4-5 hours after ingestion. (rxlist.com)
  • Verelan® PM (verapamil hydrochloride extended-release capsules) for oral use is indicated for the treatment of hypertension , to lower blood pressure. (rxlist.com)
  • Verapamil, sold under various trade names, is a medication used for the treatment of high blood pressure, chest pain from not enough blood flow to the heart, and supraventricular tachycardia. (wikipedia.org)
  • Verapamil is available as a generic medication. (wikipedia.org)
  • Tarka is the brand name of an oral antihypertensive medication that combines a slow release formulation of verapamil hydrochloride, a calcium channel blocker, and an immediate release formulation of trandolapril, an ACE inhibitor. (wikipedia.org)
  • Verapamil may also be used for purposes not listed in this medication guide. (cigna.com)
  • Verapamil is another commonly used medication. (clinicaltrials.gov)
  • The verapamil, insulin and oral medication combo group had a decrease of 24mg/dL. (empr.com)
  • Verapamil is a prescription medication used to treat chest pain, an irregular heartbeat, and high blood pressure. (rxwiki.com)
  • However, initial doses of 120 mg a day may be warranted in patients who may have an increased response to verapamil (e.g., elderly, small people, etc. (rxlist.com)
  • While verapamil does not appear to have a high risk of interacting with normal doses of vitamin D, it does interact with other vitamins and minerals, including niacin and magnesium. (livestrong.com)
  • In a study of 22 patients with keloids, patients were treated with surgical excision in combination with reconstruction with W-plasty or skin grafting and injection of verapamil (5 treatments of verapamil at 2.5 mg/mL-varying doses from 0.5-5 mL), depending on keloid size) over a 2-month period and were evaluated at 2-year follow-up. (medscape.com)
  • In a case series, Skaria reported complete resolution of 4 of 6 keloids and 1 of 2 hypertrophic scars at 1-year follow-up after surgical removal of the scar and further intralesional injection of verapamil at doses of 2.5 mg/mL. (medscape.com)
  • The extraction curves of verapamil concentrations in blood from the ascending aorta and hepatic vein were similar to those reported after single intravenous doses of indocyanine green. (nih.gov)
  • Mean hepatic extraction of verapamil in four patients who received intravenous doses was 0.86 (range 0.84 to 0.89) and in four who received intra-arterial doses was 0.87 (range 0.83 to 0.89). (nih.gov)
  • In 2005, Tebbutt and colleagues (1) showed that lipid emulsion therapy provided a survival advantage in rats that received toxic doses of verapamil. (annals.org)
  • The authors indicated that subsequent trials are being planned to test the efficacy of verapamil at higher doses, which may be needed to produce a therapeutic effect in some patients. (empr.com)
  • In general, lower initial doses (e.g., 40 mg PO every 8 hours) of verapamil may be warranted. (pdr.net)
  • Patients taking digoxin or cyclosporine should have their drug levels Verapamil More Drug Side Effects on a regular basis as verapamil may decrease Verapamil More Drug Side Effects metabolism and clearance of these Verapamil More Drug Side Effects most common symptoms caused by the plaque are curvature Verapamil More Drug Side Effects the penis Verapamil More Drug Side Effects Verapamil More Drug Side Effects erections. (geocities.jp)
  • Thirty-seven 21-day-old cardiomyopathic and thirty-seven 21-day-old normal hamsters were divided into five groups each: verapamil-, propranolol-, digoxin-, hydralazine-, and saline-injected. (ahajournals.org)
  • Digoxin Digoxin and digitoxin Digitoxin plasma concentrations are increased by verapamil Verapamil . (vetstream.com)
  • Verapamil HCl is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell membrane of the arterial smooth muscle as well as in conductile and contractile myocardial cells. (nih.gov)
  • This property increases myocardial oxygen delivery in patients with coronary artery spasm and is responsible for the effectiveness of verapamil hydrochloride in vasospastic (Prinzmetal's or variant) as well as unstable angina at rest. (nih.gov)
  • This unloading of the heart reduces myocardial energy consumption and oxygen requirements and probably accounts for the effectiveness of verapamil hydrochloride in chronic stable effort angina. (nih.gov)
  • Myocardial protection from ischemic arrest: potassium and verapamil cardioplegia. (biomedsearch.com)
  • This study has investigated the technique of preserving myocardial function by a single bolus intracoronary infusion of combination potassium and verapamil at the onset of ischemic arrest. (biomedsearch.com)
  • Sixty-one dogs underwent cardiopulmonary bypass with 60 min of ischemic arrest: 25 received no myocardial protection, 12 received a single intracoronary bolus of KCl, 12 received combination verapamil and KCl, and 12 received verapamil alone. (biomedsearch.com)
  • Verapamil preserves myocardial contractility in the hereditary cardiomyopathy of the Syrian hamster. (ahajournals.org)
  • Of the five cardiomyopathic groups, only verapamil reduced myocardial damage. (ahajournals.org)
  • However, when saline-treated cardiomyopathic hamsters were compared with drug-treated cardiomyopathic hamsters, only verapamil preserved myocardial contractility. (ahajournals.org)
  • We conclude that verapamil helped protect the myocardium of genetically cardiomyopathic hamsters against structural damage, and helped preserve myocardial contractility. (ahajournals.org)
  • Ibuprofen and verapamil treatment resulted in less myocardial damage after 48 h than placebo treatment, but the differences were generally not statistically significant. (eurekamag.com)
  • Verapamil controls arrhythmias, high blood pressure, and angina but does not cure these conditions. (medlineplus.gov)
  • patients with refractory Verapamil More Drug Side Effects arrhythmias, mexiletine may be combined with other antiarrhythmic. (geocities.jp)
  • Verapamil is reserved in those in which adenosine produces severe symptoms, in those where arrhythmias recur or for patients with poor venous acess, patients with bronchospasm or those taking agents that interfere with adenosine action or metabolism like methylxanthines and dypiridamole. (bestbets.org)
  • These results suggest that verapamil may preferentially alter the slow responses seen in infarcted tissues, thereby reducing a source of reentrant activity and associated arrhythmias. (aspetjournals.org)
  • In a randomized clinical trial, Margaret Shanthi et al compared intralesional verapamil and intralesional TAC for the treatment of keloids and hypertrophic scars, reporting a reduction in vascularity, pliability, height, and width in both groups after 3 weeks of treatment. (medscape.com)
  • In 2014, Shalev's UAB research lab discovered that verapamil completely reversed Type 1 diabetes in animal models and sought to test the effects of the drug in human subjects in a clinical trial, funded by a $2.1 million grant from the JDRF. (eurekalert.org)
  • The UAB clinical trial discovered that when a patient takes verapamil, beta cell function is preserved, enabling the body to produce more of its own insulin. (eurekalert.org)
  • The verapamil clinical trial monitored 24 patients age 18 to 45, each over the course of one year. (eurekalert.org)
  • The UAB verapamil-diabetes clinical trial aims to enroll 52 participants between the ages of 19 and 45. (uab.edu)
  • The findings come from a University of Alabama Birmingham research paper, and will form part of a larger first-of-its-kind verapamil clinical trial. (empr.com)
  • A clinical trial found that patients with CRS with nasal polyps improved with Verapamil therapy. (physiciansweekly.com)
  • A clinical trial studying the use of Verapamil (a drug currently in use for cardiovascular disease and cluster headache) in alleviating chronic rhinosinusitis (CRS) with nasal polyps revealed significant improvement in the symptoms of this subset of patients. (physiciansweekly.com)
  • The clinical trial results, published online today in the Journal of Allergy and Clinical Immunology: In Practice, suggest that Verapamil represents a promising novel therapy for the treatment of CRS with nasal polyps. (physiciansweekly.com)
  • Verapamil hydrochloride extended-release tablets, USP is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist). (nih.gov)
  • Verapamil hydrochloride dilates the main coronary arteries and coronary arterioles, both in normal and ischemic regions, and is a potent inhibitor of coronary artery spasm, whether spontaneous or ergonovine-induced. (nih.gov)
  • Verapamil hydrochloride (verapamil HCl) tablets, USP is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) available for oral administration in film-coated tablets containing 40 mg, 80 mg or 120 mg of verapamil hydrochloride. (nih.gov)
  • Trandolapril is an ACE inhibitor, and verapamil is a calcium channel blocker . (medicinenet.com)
  • Verapamil is also used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein . (thefullwiki.org)
  • Verapamil is a first-generation inhibitor that is well-established in blocking P-glycoprotein. (uspharmacist.com)
  • Verapamil is a first-generation inhibitor that is well-established in blocking P-glycoprotein," said Benjamin S. Bleier, MD, and senior author of the study. (empr.com)
  • S)-(-)-Verapamil Hydrochloride is an inhibitor of AR. (scbt.com)
  • A Phase Ib exploratory outcome will be to determine the efficacy of Verapamil HCl Intranasal using SNOT-22 scores. (clinicaltrials.gov)
  • The goal of this study is to evaluate the safety and efficacy of intranasal Verapamil in CRSwNP. (clinicaltrials.gov)
  • In a single-blind randomized study, the efficacy of intravenous flecainide (2 mg/kg/10 minutes) versus verapamil (10 mg/1 minute) was assessed in 40 patients with paroxysmal atrial fibrillation (AF) or atrial flutter (AFI). (nih.gov)
  • Verapamil, a calcium channel blocker, has shown significant efficacy in alleviating symptoms of patients with chronic rhinosinusitis (CRS) with nasal polyps. (empr.com)
  • Verapamil was one of five L-type Ca+2 channel antagonists initially screened to test for its efficacy in modulating autophagy . (stanford.edu)
  • We aimed to evaluate the efficacy of intralesional verapamil (ILVI) compared with intralesional HA in patients with early onset of Peyronie's disease (PD). (urotoday.com)
  • Verapamil is also used intra-arterially to treat cerebral vasospasm. (wikipedia.org)
  • The authors present a series of 10 patients with cerebral vasospasm who underwent 12 procedures in which they received ≥ 20 mg of intraarterial verapamil per procedure. (thejns.org)
  • Results indicate improved outcomes for those in the verapamil group compared to others receiving a placebo. (uspharmacist.com)
  • The randomized, double-blind, placebo-controlled human trial identified verapamil as a safe, effective, and promising therapy -- a groundbreaking finding in the field of diabetes research. (eurekalert.org)
  • Eleven patients received verapamil and 13 received placebo. (eurekalert.org)
  • neither Myers nor her UAB doctors know yet whether she had the verapamil or the placebo. (uab.edu)
  • Results showed improved outcomes for the verapamil group compared with the placebo group, although the treatment effect was significantly limited among patients with higher body mass indices. (empr.com)
  • An analysis of these patients demonstrated improved outcomes for those in the Verapamil group in relation to those in the placebo group. (physiciansweekly.com)
  • A double blind placebo controlled comparison of verapamil, atenolol, and their combination in patients with chronic stable angina pectoris. (bmj.com)
  • ST segment depression at peak exercise, assessed by 16 point precordial mapping, was reduced by all active treatments from 7.1 on placebo to 2.7, 0.9, and 0.6 mm on atenolol, verapamil, and the combination respectively. (bmj.com)
  • Mean left ventricular ejection fraction fell significantly from 60% on placebo to 53% on the combination but was unchanged on verapamil and atenolol. (bmj.com)
  • There was a lower mortality with ibuprofen treatment than with verapamil or placebo. (eurekamag.com)
  • Verapress MR tablets contain the active ingredient verapamil, which is a type of medicine called a calcium-channel blocker. (netdoctor.co.uk)
  • Verapress MR tablets are a long-acting or 'modified-release' form of verapamil. (netdoctor.co.uk)
  • Verapamil hydrochloride extended-release tablets USP, 180 mg and 240 mg meet USP Dissolution Test 3. (nih.gov)
  • and as light violet, oval, film-coated tablets (caplets) containing 120 mg of verapamil hydrochloride. (searlehealthnet.com)
  • There are a number of generic manufacturers of verapamil tablets and injectables. (ijpc.com)
  • This listing is restricted to people already stabilised on antihypertensive treatment with trandolapril 4 mg and verapamil SR 240 mg 1 who wish to reduce the number of tablets they take each day. (nps.org.au)
  • The authors conclude that removal of cartilage reduces muscle reactivity and increases the potency of verapamil in guinea-pig trachealis, suggesting a role for cartilage derived calcium in excitation/contraction coupling mechanisms. (cdc.gov)
  • Do not take trandolapril and verapamil if you are pregnant or breast-feeding. (medlineplus.gov)
  • If you become pregnant while taking trandolapril and verapamil, call your doctor immediately. (medlineplus.gov)
  • The combination of trandolapril and verapamil is used to treat high blood pressure. (medlineplus.gov)
  • The combination of trandolapril and verapamil comes as a tablet to take by mouth. (medlineplus.gov)
  • The combination of trandolapril and verapamil controls high blood pressure but does not cure it. (medlineplus.gov)
  • Do not stop taking trandolapril and verapamil without talking to your doctor. (medlineplus.gov)
  • Your doctor will probably tell you not to take trandolapril and verapamil if you have diabetes and you are also taking aliskiren. (medlineplus.gov)
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking trandolapril and verapamil. (medlineplus.gov)
  • Do not drive a car or operate machinery until you know how trandolapril and verapamil will affect you. (medlineplus.gov)
  • Trandolapril and verapamil may cause an upset stomach. (medlineplus.gov)
  • Take trandolapril and verapamil with food or milk.Talk to your doctor before using salt substitutes containing potassium. (medlineplus.gov)
  • This product contains 2 medications, trandolapril and verapamil . (medicinenet.com)
  • Influence of cartilage on reactivity and on the effectiveness of verapamil in guinea pig isolated airway smooth muscle. (cdc.gov)
  • A formulation for preparing Verapamil Hydrochloride 2.5-mg/mL Injection. (ijpc.com)
  • Seven cats were pretreated with a bolus injection of Verapamil, followed by a continuous infusion of Verapamil during the ischaemic period. (springer.com)
  • To compare the response to tiocolchicine and verapamil injection in the plaque of patients with Peyronie's disease. (urotoday.com)
  • Infusion of verapamil during the late phase of the secretory response to glucose demonstrated that the inhibition of insulin release was an immediate and reversible phenomenon. (diabetesjournals.org)
  • We report an additional series of 11 medically refractory cases of presumed or proved reversible cerebral vasoconstriction syndrome successfully treated with intra-arterial verapamil infusion. (ajnr.org)
  • Studies have shown that verapamil may be effective in the preventive treatment of migraine and cluster headache patients. (headaches.org)
  • Normal sinus rhythm is usually not affected, but in patients with sick sinus syndrome, verapamil hydrochloride may interfere with sinus-node impulse generation and may induce sinus arrest or sinoatrial block. (nih.gov)
  • This property accounts for the ability of verapamil hydrochloride to slow the ventricular rate in patients with chronic atrial flutter or atrial fibrillation. (nih.gov)
  • D'Andrea et al, from a case-control comparative study, reported resolution in 54% of the patients who had their keloids treated by a combination of surgical excision, silicon sheeting, and intralesional verapamil versus 18% in the control group without intralesional verapamil. (medscape.com)
  • Lawrence reported 55% cured earlobe keloids in 52% of the patients after the combination of surgical excision, intralesional verapamil, and pressure earrings after an average of 28 months of follow-up. (medscape.com)
  • Ahuja et al studied 40 patients (48 scars) and compare the effects of triamcinolone and verapamil injections. (medscape.com)
  • An online article in the Journal of Allergy and Clinical Immunology: In Practice reports that a subset of those patients significantly improved on verapamil. (uspharmacist.com)
  • The plasma protein binding of verapamil was not altered in the postsurgical state or in the dialysis patients. (nih.gov)
  • Patients who did not convert to sinus rhythm after treatment with verapamil were treated with flecainide and observed for another hour. (nih.gov)
  • This retrospective observational case series includes 12 patients with vasospasm after SAH who collectively received 16 treatments with intra-arterial verapamil during a 2-year period at our institution. (ajnr.org)
  • Patients were treated with intra-arterial verapamil for vasospasm 9 ± 4 days after SAH with a range from 1 to 16 days. (ajnr.org)
  • Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy. (ahajournals.org)
  • Verapamil improves exercise capacity in patients with hypertrophic cardiomyopathy (HCM), but its mechanism of action are unknown. (ahajournals.org)
  • High-temporal-resolution time-activity curves from gated technetium-99m radionuclide angiograms were analyzed before and after verapamil therapy in 40 patients, of whom 16 were also studied during propranolol therapy (80-960 mg/day). (ahajournals.org)
  • Only 30% of patients had evidence of diastolic dysfunction during verapamil. (ahajournals.org)
  • Thus, LV diastolic filling is abnormal in a high percentage of patients with HCM, and verapamil normalizes or improves these abnormalities without altering systolic function. (ahajournals.org)
  • This mechanism may contribute to the clinical improvement of many HCM patients during verapamil therapy. (ahajournals.org)
  • A new study has found that verapamil - used to treat high blood pressure, irregular heartbeat and migraine - can lower fasting glucose levels in diabetic patients. (empr.com)
  • A cross-sectional observational study included 1,484 diabetic patients, 174 of whom were verapamil users. (empr.com)
  • Patients who took verapamil and insulin lowered their serum glucose levels by 37mg/dL, almost 4 times higher when looking at the entire sample of diabetes patients. (empr.com)
  • The study's authors hypothesize that verapamil can promote beta-cell mass in the pancreas - the cells that create insulin but are diminished in diabetes patients. (empr.com)
  • Limited data are available regarding long-term use of verapamil in pediatric patients. (pdr.net)
  • Twenty-five patients were randomized, 13 received thiocolchicine and 12 were treated with verapamil. (urotoday.com)
  • The curvature improved in 69% of patients treated with thiocolchicine and in 66% of those who received verapamil. (urotoday.com)
  • Patients have been double-blinded randomly divided into two groups (1 : 1 ratio): Group A received intralesional treatment with Verapamil (10 mg in 5 mL of normal saline water) weekly for 12 weeks, while group B received intralesional treatment with HA (0.8% highly purified sodium salt HA 16 mg/2 mL) weekly for 12 weeks. (urotoday.com)
  • On the combination only four patients developed evidence of ischaemia during exercise compared with seven on verapamil and ten on atenolol. (bmj.com)
  • Ten patients were identified who had undergone a total of 12 procedures during which ≥20 mg of intraarterial verapamil had been administered. (thejns.org)
  • The announcement of the $2.1 million, JDRF-funded "repurposing of verapamil as a beta cell survival therapy in type 1 diabetes" was picked up around the world as the news was promising - UAB research had shown the common blood pressure drug verapamil completely reversed diabetes in mice by lowering TXNIP levels in beta cells. (uab.edu)
  • Previous research by the School of Medicine found that verapamil completely reversed diabetes in mice models. (empr.com)
  • Verapamil is used for controlling ventricular rate in supraventricular tachycardia and migraine headache prevention. (wikipedia.org)
  • Verapamil hydrochloride decreases the frequency of episodes of paroxysmal supraventricular tachycardia. (nih.gov)
  • Verapamil hydrochloride does not alter total serum calcium levels. (nih.gov)
  • Verapamil hydrochloride does not alter the normal atrial action potential or intraventricular conduction time, but in depressed atrial fibers it decreases amplitude, velocity of depolarization, and conduction velocity. (nih.gov)
  • Verapamil hydrochloride does not present the phenomenon of polymorphism under the conditions evaluated. (mdpi.com)
  • Verapamil is in a class of medications called calcium-channel blockers. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to verapamil, any other medications, or any ingredients in verapamil. (medlineplus.gov)
  • Many other medications may also interact with verapamil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • Verapamil belongs to the class of medications called calcium channel blockers . (medbroadcast.com)
  • Verapamil can interact with beta-blockers, nonsteroidal anti-inflammatory drugs, and certain heart medications. (internationaldrugmart.com)
  • Verapamil has been reported to be effective in both short-term and long-term treatment of mania and hypomania. (wikipedia.org)
  • Serious verapamil poisoning: treatment with intravenous calcium gluconate. (bmj.com)
  • [ 3 ] Addition of magnesium oxide to the verapamil treatment protocol enhances the antimanic effect. (thefullwiki.org)
  • What is the role of verapamil in the treatment of keloids and hypertrophic scars? (medscape.com)
  • This group concluded that even though the criterion standard first-line treatment is still triamcinolone, verapamil is almost equally effective, with very few adverse effects, and offers a therapeutic option to treat larger and recalcitrant scars. (medscape.com)
  • Treatment of hypertrophic obstructive cardiomyopathy with verapamil. (bmj.com)
  • From all available clinical data it is concluded that verapamil treatment is superior to beta-blocker therapy. (bmj.com)
  • Verapamil has been Food and Drug Administration approved and available for prescription for the treatment of high blood pressure for more than three decades. (eurekalert.org)
  • This study evaluated the activity and toxicity following treatment with a combination of DTIC, IFN[alpha]2b and verapamil (VPL). (diva-portal.org)
  • Treatment with verapamil during long-term ethanol consumption prevented the development of these metabolic and functional abnormalities. (ahajournals.org)
  • Combining certain cholesterol drugs with verapamil may cause you to have increased levels of the cholesterol drug in your body. (healthline.com)
  • Combining this drug with verapamil may impair your left ventricle. (healthline.com)
  • as I have taken this drug before, and was switched off a nasty beta blocker Toprol xl -and put on verapamil - about 3months ago. (medhelp.org)
  • Verapamil Calcium Channel Blocker Drug. (123rf.com)
  • Both NZ and IZ cells showed a significant increase in refractory period after verapamil superfusion Vmax was decreased only in the IZ in which slow responses were further depressed by the drug. (aspetjournals.org)
  • Verapamil reversed resistance to doxorubicin in a human multiple myeloma cell line selected for multiple drug resistance. (aacrjournals.org)
  • Verapamil had no effect on these lesions in the drug-sensitive cells. (aacrjournals.org)
  • In addition, verapamil did not affect chemotherapeutic cytotoxicity or transport in the drug-sensitive cell line. (aacrjournals.org)
  • Verapamil appears to reverse doxorubicin resistance in this human myeloma cell line by blocking enhanced drug efflux, leading to increased drug accumulation and enhanced DNA damage. (aacrjournals.org)
  • Interest has since increased in the intra-arterial use of calcium channel antagonists, including verapamil, nimodipine, and nicardipine. (ajnr.org)
  • Verapamil HCl, USP is not chemically related to other cardioactive drugs. (nih.gov)
  • Verapamil is a potent calcium antagonist known to inhibit excitation-contraction coupling in both myocardium and myometrium. (diabetesjournals.org)
  • DeBoer LWV, Strauss HW, Kloner RA, Rude RE, Davis RF, Maroko PR, Braunwald E (1980) Autoradiographic method for measuring the ischemic myocardium at risk: Effects of verapamil on infarct size after experimental coronary artery occlusion. (springer.com)
  • By decreasing the influx of calcium, verapamil hydrochloride prolongs the effective refractory period within the AV node and slows AV conduction in a rate-related manner. (nih.gov)
  • This was consistent with the proposal that verapamil blocks the smaller influx of calcium occurring during the sustained secondary phase of contraction. (cdc.gov)
  • In this study, improvement in angiographic vasospasm after intra-arterial verapamil administration is demonstrated with quantitative, blinded methods. (ajnr.org)
  • Preliminary studies of the effects of intra-arterial verapamil on angiographic vasospasm have yielded mixed and often poorly quantified results. (ajnr.org)
  • Four years later, lipid emulsion was used to manage a human patient with verapamil overdose (2). (annals.org)
  • To describe the use of lipid emulsion in the management of a patient with verapamil overdose. (annals.org)
  • What if you overdose on Verapamil? (internationaldrugmart.com)
  • If you suspect an overdose of Verapamil, seek medical attention immediately. (internationaldrugmart.com)
  • In normal subjects, plasma protein binding of verapamil was not affected by addition of its major metabolite, norverapamil, in ratios of 1.2 to 26.3 (norverapamil/verapamil) or by the addition of 10 micrograms of warfarin. (nih.gov)
  • The present study showed that verapamil enantiomers and their major metabolites [norverapamil and N- desalkylverapamil (D617)] inhibited CYP3A in a time- and concentration-dependent manner by using pooled human liver microsomes and the cDNA-expressed CYP3A4 (+b 5 ). (aspetjournals.org)
  • The values of the inactivation kinetic parameters k inact and K I obtained with the cDNA-expressed CYP3A4 (+b 5 ) were 0.39 min -1 and 6.46 μM for R -verapamil, 0.64 min -1 and 2.97 μM for S -verapamil, 1.12 min -1 and 5.89 μM for (±)-norverapamil, and 0.07 min -1 and 7.93 μM for D617. (aspetjournals.org)
  • The in vitro unbound fraction was 0.84 for S -verapamil, 0.68 for R -verapamil, and 0.84 for (±)-norverapamil. (aspetjournals.org)
  • Verapamil is believed to have stronger effects on symptoms of VM. (clinicaltrials.gov)
  • Cartilage removal increased the antispasmogenic and spasmolytic effects of verapamil on contraction induced by histamine and methacholine. (cdc.gov)
  • Preliminary studies of the effects of the calcium channel antagonist verapamil on angiographic vasospasm have yielded mixed and/or qualitative results. (ajnr.org)
  • The next model used to explore the effects of verapamil on HD was the fruit fly, a commonly used model for many experiments. (stanford.edu)
  • Effects of 1 microM verapamil on action potentials of Purkinje fibers from normal and infarcted zones (NZ and IZ) were studied using conventional microelectrode techniques. (aspetjournals.org)
  • Effects enhanced by verapamil. (vetstream.com)
  • Verapamil also inhibited gliclazide-induced insulin release. (diabetesjournals.org)
  • Beyond verapamil allowing subjects with Type 1 diabetes the ability to live a life with less external insulin dependence, these findings will impact the quality of life that they can have. (brightsurf.com)
  • Verapamil enhances the effect of theophylline Theophylline possibly leading to toxicity. (vetstream.com)