Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The hollow, muscular organ that maintains the circulation of the blood.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.
A characteristic symptom complex.
Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).
Laceration or tearing of cardiac tissues appearing after MYOCARDIAL INFARCTION.
Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA.
Disease having a short and relatively severe course.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Quinolines substituted in any position by one or more nitro groups.
A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading.
Contraceptive devices placed high in the uterine fundus.
Method to determine the occurrence of OVULATION by direct or indirect means. Indirect methods examine the effects of PROGESTERONE on cervical mucus (CERVIX MUCUS), or basal body temperature. Direct ovulation detection, generally used in fertility treatment, involves analyses of circulating hormones in blood and ULTRASONOGRAPHY.
Chemical substances that are destructive to spermatozoa used as topically administered vaginal contraceptives.
Methods of contraception in which physical, chemical, or biological means are used to prevent the SPERM from reaching the fertilizable OVUM.
Intrauterine contraceptive devices that depend on the release of metallic copper.
Silver. An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.
Individuals who have developed skills, physical stamina and strength or participants in SPORTS or other physical activities.
Activities or games, usually involving physical effort or skill. Reasons for engagement in sports include pleasure, competition, and/or financial reward.
A change in cardiovascular function resulting in a reduction in BLOOD VOLUME, and reflex DIURESIS. It occurs frequently after actual or simulated WEIGHTLESSNESS.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
A group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. NEUROFIBROMATOSIS 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., NEUROFIBROMATOSIS 2, neurofibromatosis 3, etc.) have been described. (From Neurochirurgie 1998 Nov;44(4):267-72)
Carrying out of specific physical routines or procedures by one who is trained or skilled in physical activity. Performance is influenced by a combination of physiological, psychological, and socio-cultural factors.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Surgery performed on the heart.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.
A type of heart valve surgery that involves the repair, replacement, or reconstruction of the annulus of the MITRAL VALVE. It includes shortening the circumference of the annulus to improve valve closing capacity and reinforcing the annulus as a step in more complex valve repairs.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
The valve between the left atrium and left ventricle of the heart.
The tendinous cords that connect each cusp of the two atrioventricular HEART VALVES to appropriate PAPILLARY MUSCLES in the HEART VENTRICLES, preventing the valves from reversing themselves when the ventricles contract.
Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows the backflow of blood into left atrium leading to MITRAL VALVE INSUFFICIENCY; SYSTOLIC MURMURS; or CARDIAC ARRHYTHMIA.
Conical muscular projections from the walls of the cardiac ventricles, attached to the cusps of the atrioventricular valves by the chordae tendineae.
Large aggregates of CELESTIAL STARS; COSMIC DUST; and gas. (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed)
Small, abnormal spherical red blood cells with more than the normal amount of hemoglobin.
Hospital department which administers all departmental functions and the provision of surgical diagnostic and therapeutic services.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.
The circulation of blood through the CORONARY VESSELS of the HEART.
Visualization of the heart structure and cardiac blood flow for diagnostic evaluation or to guide cardiac procedures via techniques including ENDOSCOPY (cardiac endoscopy, sometimes refered to as cardioscopy), RADIONUCLIDE IMAGING; MAGNETIC RESONANCE IMAGING; TOMOGRAPHY; or ULTRASONOGRAPHY.
The veins and arteries of the HEART.
The finer blood vessels of the vasculature that are generally less than 100 microns in internal diameter.
Drugs used to cause dilation of the blood vessels.

Myocardial oxygenation during high work states in hearts with postinfarction remodeling. (1/2864)

BACKGROUND: Postinfarction left ventricular remodeling (LVR) is associated with reductions in myocardial high-energy phosphate (HEP) levels, which are more severe in animals that develop overt congestive heart failure (CHF). During high work states, further HEP loss occurs, which suggests demand-induced ischemia. This study tested the hypothesis that inadequate myocyte oxygen availability is the basis for these HEP abnormalities. METHODS AND RESULTS: Myocardial infarction was produced by left circumflex coronary artery ligation in swine. Studies were performed in 20 normal animals, 14 animals with compensated LVR, and 9 animals with CHF. Phosphocreatine (PCr)/ATP was determined with 31P NMR and deoxymyoglobin (Mb-delta) with 1H NMR in myocardium remote from the infarct. Basal PCr/ATP tended to be decreased in postinfarct hearts, and this was significant in animals with CHF. Infusion of dobutamine (20 microg x kg-1 x min-1 IV) caused doubling of the rate-pressure product in both normal and LVR hearts and resulted in comparable significant decreases of PCr/ATP in both groups. This decrease in PCr/ATP was not associated with detectable Mb-delta. In CHF hearts, rate-pressure product increased only 40% in response to dobutamine; this attenuated response also was not associated with detectable Mb-delta. CONCLUSIONS: Thus, the decrease of PCr/ATP during dobutamine infusion is not the result of insufficient myocardial oxygen availability. Furthermore, in CHF hearts, the low basal PCr/ATP and the attenuated response to dobutamine occurred in the absence of myocardial hypoxia, indicating that the HEP and contractile abnormalities were not the result of insufficient oxygen availability.  (+info)

Myocardial creatine kinase kinetics in hearts with postinfarction left ventricular remodeling. (2/2864)

This study examined whether alterations in myocardial creatine kinase (CK) kinetics and high-energy phosphate (HEP) levels occur in postinfarction left ventricular remodeling (LVR). Myocardial HEP and CK kinetics were examined in 19 pigs 6 wk after myocardial infarction was produced by left circumflex coronary artery ligation, and the results were compared with those from 9 normal pigs. Blood flow (microspheres), oxygen consumption (MVO2), HEP levels [31P magnetic resonance spectroscopy (MRS)], and CK kinetics (31P MRS) were measured in myocardium remote from the infarct under basal conditions and during dobutamine infusion (20 micrograms. kg-1. min-1 iv). Six of the pigs with LVR had overt congestive heart failure (CHF) at the time of study. Under basal conditions, creatine phosphate (CrP)-to-ATP ratios were lower in all transmural layers of hearts with CHF and in the subendocardium of LVR hearts than in normal hearts (P < 0.05). Myocardial ATP (biopsy) was significantly decreased in hearts with CHF. The CK forward rate constant was lower (P < 0.05) in the CHF group (0.21 +/- 0.03 s-1) than in LVR (0.38 +/- 0.04 s-1) or normal groups (0.41 +/- 0.03 s-1); CK forward flux rates in CHF, LVR, and normal groups were 6.4 +/- 2.3, 14.3 +/- 2.1, and 20.3 +/- 2.4 micromol. g-1. s-1, respectively (P < 0.05, CHF vs. LVR and LVR vs. normal). Dobutamine caused doubling of the rate-pressure product in the LVR and normal groups, whereas CHF hearts failed to respond to dobutamine. CK flux rates did not change during dobutamine in any group. The ratios of CK flux to ATP synthesis (from MVO2) under baseline conditions were 10.9 +/- 1.2, 8. 03 +/- 0.9, and 3.86 +/- 0.5 for normal, LVR, and CHF hearts, respectively (each P < 0.05); during dobutamine, this ratio decreased to 3.73 +/- 0.5, 2.58 +/- 0.4, and 2.78 +/- 0.5, respectively (P = not significant among groups). These data demonstrate that CK flux rates are decreased in hearts with postinfarction LVR, but this change does not limit the response to dobutamine. In hearts with end-stage CHF, the changes in HEP and CK flux are more marked. These changes could contribute to the decreased responsiveness of these hearts to dobutamine.  (+info)

Nicotine-modified postinfarction left ventricular remodeling. (3/2864)

Cigarette smoking has been noted to impair wound healing in tissues such as skin, bone, and gut. This study was designed to examine whether nicotine adversely affects postinfarction cardiac wound healing and remodeling in an experimental model of myocardial infarction. For this purpose, two groups of rats were studied. The control group received a simple bandage, and the nicotine group had a section (1.75 mg/day) of a nicotine patch attached on their backs. After a 7-day treatment period, an anterior wall infarction was induced. A bandage-free 7-day healing period followed, after which hearts were isolated for mechanical tests. Nicotine-treated rats developed significantly enlarged left ventricles with thin, infarcted walls and a rightward shift in the passive pressure-volume relationship. Pressure-strain analysis also indicated possible changes in the material properties of the wound for nicotine-treated rats. In conclusion, nicotine has significant adverse effects on postinfarction healing and left ventricular remodeling. These observations have important clinical implications because of the enhanced risk for development of heart failure.  (+info)

Endothelin system-dependent cardiac remodeling in renovascular hypertension. (4/2864)

The aim of the present study was to analyze whether the cardiac endothelin system contributes to cardiac remodeling in rats with 2-kidney, 1 clip (2K1C) renovascular hypertension. The endothelin system seems to be a promising candidate for cardiac remodeling because endothelin (ET)-1 promotes growth of cardiomyocytes in vitro and induces cardiac collagen synthesis. The activity of the cardiac endothelin system was analyzed by measuring cardiac tissue big ET-1 and ET-1 concentrations as well as by estimating the cardiac expression of the ETA and ETB receptors 10 days, 4 weeks, and 12 weeks after the renal artery was clipped. The effects of long-term treatment with ETA, ETB, and combined ETA/ETB receptor antagonists on cardiac hypertrophy, media/lumen ratio of intracardiac arteries, and left ventricular fibrosis were also analyzed. This study demonstrated that the overall left ventricular cardiac endothelin system has a similar activity in the early, middle, and late stages of 2K1C renovascular hypertension compared with sham-operated controls. Fibrosis of the left ventricle and hypertrophy of intracardiac arteries, however, were markedly altered after long-term treatment with endothelin receptor antagonists in a blood pressure-independent manner. These 2 effects are mediated by different subtypes of endothelin receptors. ETA receptor blockade completely normalized the hypertrophy of intracardiac arteries (P<0. 01 compared with 2K1C without treatment) in renovascular hypertension, whereas the ETB antagonist reduced cardiac fibrosis of the left ventricle (P<0.001 compared with 2K1C without treatment) to baseline values. This study demonstrates that the cardiac endothelin system plays an important role in the development of cardiac fibrosis as well as in hypertrophy of intracardiac arteries in 2K1C renovascular hypertensive rats.  (+info)

Decreased left ventricular filling pressure 8 months after corrective surgery in a 55-year-old man with tetralogy of Fallot: adaptation for increased preload. (5/2864)

A 55-year-old man with tetralogy of Fallot underwent corrective surgery. Left ventricular filling pressure increased markedly with increased left ventricular volume one month after surgery, then decreased over the next 7 months, presumably due to increased left ventricular compliance.  (+info)

Beneficial effect of myocardial angiogenesis on cardiac remodeling process by amlodipine and MCI-154. (6/2864)

The present study examined the effect of long-term treatment with amlodipine and MCI-154 (a Ca2+ sensitizer) on progressive cardiac dysfunction and microvasculature in the dilated cardiomyopathic (DCM) hamster heart. After treatment of DCM hamsters (Bio 53.58) with amlodipine or MCI-154 for 15 wk from the age of 5 wk, amlodipine and MCI-154 were found to cause an increase in left ventricular percent fractional shortening and decreases in left ventricular diastolic dimension and isovolumic relaxation time in echocardiograms (P < 0.01). A hemodynamic study showed that the diastolic time constant decreased in the amlodipine-treatment group (P < 0.05). In a morphometric study employing a double-staining method that discriminated arteriolar and venular capillaries, amlodipine and MCI-154 caused increases in total capillary density (P < 0.05) and the proportion of venular capillaries (P < 0.05). Moreover, Northern blot analysis showed that the expression of mRNA for vascular endothelial growth factor was significantly increased by amlodipine and MCI-154. They preserve coronary microvasculature in the DCM hamster and might induce angiogenesis of small vessels, thereby contributing to preservation of cardiac systolic and diastolic function.  (+info)

Effects of AT1-receptor blockade on progression of left ventricular dysfunction in dogs with heart failure. (7/2864)

The objective of the present study was to determine the effects of early long-term monotherapy with the angiotensin II AT1-receptor antagonist valsartan on the progression of left ventricular (LV) dysfunction and remodeling in dogs with moderate heart failure (HF). Studies were performed in 30 dogs with moderate HF produced by multiple sequential intracoronary microembolizations. Embolizations were discontinued when LV ejection fraction was 30-40%. Two weeks after the last embolization, dogs were randomized to 3 mo of oral therapy with low-dose valsartan (400 mg twice daily, n = 10), to high-dose valsartan (800 mg twice daily, n = 10), or to no treatment at all (control, n = 10). Treatment with valsartan significantly reduced mean aortic pressure and LV end-diastolic pressure compared with control. In untreated dogs, LV ejection fraction decreased (37 +/- 1 vs. 29 +/- 1%, P = 0.001) and end-systolic volume (ESV) and end-diastolic volume (EDV) increased (81 +/- 5 vs. 92 +/- 5 ml, P < 0.001; 51 +/- 3 vs. 65 +/- 3 ml, P = 0.001, respectively) after 3 mo of follow-up compared with those levels before follow-up. In dogs treated for 3 mo with low-dose valsartan, ejection fraction was preserved (37 +/- 1 vs. 38 +/- 2%, pretreatment vs. posttreatment) as was ESV but not EDV. In dogs treated for 3 mo with high-dose valsartan, ejection fraction decreased (35 +/- 1 vs. 31 +/- 2%, P = 0.02) and ESV and EDV increased in a manner comparable to those levels in controls. Valsartan had no significant effects on cardiomyocyte hypertrophy or on the extent of interstitial fibrosis. We conclude that, for dogs with moderate HF, early long-term therapy with the AT1-receptor blocker valsartan decreases preload and afterload but has only limited benefits in attenuating the progression of LV dysfunction and chamber remodeling.  (+info)

Ventricular dilatation in the absence of ACE inhibitors: influence of haemodynamic and neurohormonal variables following myocardial infarction. (8/2864)

OBJECTIVE: To examine the relation between patterns of ventricular remodelling and haemodynamic and neurohormonal variables, at rest and during symptom limited exercise, in the year following acute myocardial infarction in patients not receiving angiotensin converting enzyme (ACE) inhibitors. DESIGN: A prospective observational study. PATIENTS: 65 patients recruited following hospital admission with a transmural anterior myocardial infarction. METHODS: Central haemodynamics and neurohormonal activation at rest and during symptom limited treadmill exercise were measured at baseline before hospital discharge, one month later, and at three monthly intervals thereafter. PATIENTS were classified according to individual patterns of change in left ventricular end diastolic volumes at rest, assessed at each visit using transthoracic echocardiography. RESULTS: In most patients (n = 43, 66%) ventricular volumes were unchanged or reduced. Mean (SEM) treadmill exercise capacity and peak exercise cardiac index increased at month 12 by 200 (24) seconds (p < 0.001 v baseline) and by 0.8 (0.4) l/min/m2 (p<0.05 v baseline), respectively, in this group. In patients with limited ventricular dilatation (n = 11, 17%) exercise capacity increased by 259 (52) seconds (p < 0.001 v baseline) and peak exercise cardiac index improved by 0.8 (0.7) l/min/m2 (NS). In the remaining 11 patients with progressive left ventricular dilatation, exercise capacity increased by 308 (53) seconds (p< 0. 001 v baseline) and peak exercise cardiac index similarly improved by 1.3 (0.7) l/min/m2 (NS). There were trends towards increased atrial natriuretic factor (ANF) secretion at rest and at peak exercise in this group. CONCLUSIONS: Ventricular dilatation after acute myocardial infarction is a heterogeneous process that is progressive in only a minority of patients. Compensatory mechanisms, including ANF release, appear capable of maintaining and improving exercise capacity in most patients for at least 12 months, even in those with a progressive increase in ventricular size.  (+info)

Left myocardial infarction (MI), has a negative impact of long term morbidity and mortality. Even in patients treated successfully by angioplasty in the acute phase of infarct, the remodelling is observed in approximately 30% of cases. It is important to predict the occurrence of this phenomenon in the early phase after MI for the selection of patients who could eventually benefit from new therapeutic approach as for example cell replacement therapy. It has been advocated that stem cells coronary injections should be performed between the 5th and 10th day after an acute event. We hypothesise that a low dose dobutamine gated Tc-99m-mibi SPECT performed on 5th-6th day after reperfused acute MI can predict left ventricular remodelling and serve as a method to screen patients who could benefit from cell replacement therapy ...
TY - JOUR. T1 - Remodelage ventriculaire droit postradiothérapie T2 - la pièce manquante du puzzle. AU - Tadic, Marijana. AU - Cuspidi, Cesare. AU - Hering, Dagmara. AU - Venneri, Lucia. AU - Grozdic-Milojevic, Isidora. PY - 2017/2/1. Y1 - 2017/2/1. N2 - The number of studies demonstrating that right ventricular structure, function and mechanics are valuable predictors of cardiovascular and total morbidity and mortality in patients with a wide range of cardiovascular conditions is constantly increasing. Most studies that evaluated the influence of radiotherapy on the heart focused on left ventricular remodelling, which is why current guidelines only recommend detailed assessment of the left ventricle. Data regarding right ventricular changes in cancer patients treated with radiotherapy are scarce. Given that radiotherapy more often induces late cardiac impairment - unlike chemotherapy-induced cardiotoxicity, which is usually acute - it is quite reasonable to follow these patients ...
BACKGROUND: Biomaterial implantation provides a promising approach to limit adverse remodelling following myocardial infarction (MI). In this study, we determined whether implantation of heart tissue-derived decellularized extracellular matrix (ECM), which contains native biochemical and structural matrix composition, could prevent left ventricular (LV) paradoxical systolic bulging and post-MI remodeling by thickening the infarcted wall in a rat MI model.. METHODS: ECM was derived from rat hearts. MI was induced by left coronary ligation in Fischer rats. One week later, saline (75 μl, n=17) or matrix (75 μl, n=19) was directly injected into the infarcted area. Cardiac function and the infarct wall motion were assessed by left ventriculogram at 6 weeks after injection, and the hearts were harvested and processed for histology.. RESULTS: The average infarcted LV wall was 24.4% thicker in the ECM- treated group than in the saline-treated group (p=0.0084) and infarct expansion index was reduced by ...
Methods Lentiviral vectors carrying miR-31 inhibition gene (LV-miR-31- inhibition) and negative control were constructed. 17-week-old SHRs were randomly divided into 3 groups: LV-miR-31-inhibition treatment (n = 5), negative control (n = 3), and black group (n = 3). The treatment group was injected with 150ul virus solution of LV-miR-31-inhibition with a titer of 1x108 TU/ml via the tail vein. The control and blank groups were injected with an equal volume of negative control virus and enhanced infection solution (ENi. S.) respectively. Throughout the 3-week feeding period, the systolic blood pressure was measured by tail cuff, and the structure and function indexes of left ventricular were observed by high frequency echocardiography (HFUS) for each group animals. After 3 weeks all animals were sacrificed and heat tissue removed and calculated the left ventricular mass index (LVMI). The heart damage was examined by HE staining.. ...
The blinded placebo-controlled STOP-HF trial demonstrated the safety of a single endocardial administration of pSDF-1 but failed to demonstrate its primary endpoint of improved composite score at 4 months after treatment. Through a pre-specified analysis the STOP-HF trial demonstrates the potential …
Results LV remodelling occurred in 30.7% of patients. Compared with patients without remodelling, these patients had higher DHR (72±11 bpm vs 68±12 bpm, p,0.001), higher levels of peak troponin T (5.6 (2.7, 11) ug/L vs 3.7 (1.6, 7.4) ug/L, p,0.001) and creatine kinase (2083 (960, 4045) U/L vs 1469 (669, 2750) U/L, p,0.001), lower LV ejection fraction (45±10 vs 48±9%, p,0.001) and more frequently displayed left anterior descending artery as culprit (52% vs 44%, p=0.02). Median DHR was 69 bpm. DHR ,69 bpm (OR 1.5, 95% CI 1.10 to 2.04, p=0.01) and higher peak troponin T (OR 1.06, 95% CI 1.03 to 1.09, p,0.001) were independently associated with LV remodelling at follow-up.. ...
Looking for post-myocardial infarction syndrome? Find out information about post-myocardial infarction syndrome. Med any combination of signs and symptoms that are indicative of a particular disease or disorder Syndrome, Mr. Incredibles wannabe sidekick turned bad... Explanation of post-myocardial infarction syndrome
Background: Prognostic value of myocardial fibrosis in patients with non-ischemic idiopathic cardiomyopathy (NICM) is not well-defined. We sought to assess the association of focal and diffuse myocardial fibrosis to left ventricular reversed remodeling.. Methods: Patients with NICM who underwent cardiac MRI and baseline and subsequent follow-up echocardiographic were included in the study. Post-contrast T1 times were measured using Look-Locker gradient echo, and was adjusted for renal function, body size, gadolinium dose and delayed time after Gadolinium injection. Patients were followed over a median time of 29 months (20,37) to evaluate changes of left ventricular end-systolic volume index (LVESVi) over time. Linear Mixed Model was used to assess the relationship between the LVESVi during follow-up,T1 value, and delayed hyperenhancement (DHE).. Results: A total of 103 patients (mean age 51±15 years, 62% male) were included in the analysis. Mean LVEF 32±10%, LVESVi 62±39 ml/m2, and T1 time ...
© Springer International Publishing Switzerland 2016. Understanding myocardial remodelling, and developing tools for its accurate quantification, is fundamental for improving the diagnosis and treatment of myocardial infarction patients. Conventional clinical metrics, such as blood pool volume or ejection fraction, are not always distinctive. Here we describe a method for the classification of myocardial infarction from 3D diastolic and systolic left ventricle shapes, represented by point sets. Classification features included global geometric, shape and thickness descriptors, and a random forest was used for classification. Results from cross validation show an accuracy of 92.5% (leave-one-out) and 91.5% (5-fold), improving the 87% obtained with ejection fraction thresholds. These results suggest that refined remodelling metrics provide information beyond standard clinical descriptors.
89 patients were treated from August 2010 till March 2016. Baseline EF was 30±8%, LVESVI was 70±26 ml/m2, and LVEDVI was 95±31 ml/m2. Four patients (4.5%) died in-hospital and 1 (1.1%) had a stroke. Two-year survival was 87%. In 35 patients who have completed 2-year echo follow up, EF improved by 19%, LVESVI reduced by 31%, and LVEDVI reduced by 21%. NYHA class reduced from 2.6±0.5 to 1.8±0.7 (p,0,001), 6-minute walk test increased from 372±82 minutes to 425±94 minutes (p=0.002), and Minnesota Living with Heart Failure score reduced from 44±21 to 27±20 (p,0.001). Serial echocardiograms and functional evaluations at 6, 12, and 24 months demonstrated sustained improvements. ...
لتعديل بيانات أعضاء هيئة التدريس أرجو مراسلة مركز تكنولوجيا معلومات الجامعة قسم MIS ...
We determined whether chronic treatment with nipradilol, a β-blocker with vasodilating action, reduces left ventricular cavity dilation (LV remodeling) following myocardial infarction and improves cardiac performance. Myocardial infarction was produced by coronary artery ligation in 16-week-old female rats and then the rats were treated for 3-4 months with nipradilol (10 mg/kg/day) or vehicle (0.5% carboxymethylcellulose). The effect of nipradilol on LV remodeling was evaluated by assessing the left ventricular end-diastolic volume index (LVEDVI)and passive pressure-volume relation curve. Since LVEDVI depends on the infarct size, LVEDVI was compared between the vehicle and nipradilol-treated rats with similar infarct size (10-40%). At 3-4 months after myocardial infarct production, the left ventricular end-diastolic volume index in the vehicle-treated rats with myocardial infarction was significantly increased, compared with that in the sham-operated rats without infarction. The ...
Background: Common conditions such as obesity and hypertension result in hemodynamic alterations that will induce remodeling of the left ventricle (LV). However, differences between the genders in the relationship of hemodynamics to LV geometry are not well known. The present study aims to investigate differences between the genders in this respect, in a sample of elderly persons. Methods: Echocardiography and Doppler was performed in a population-based sample aged 70 - The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (n = 922). Hemodynamic patterns obtained by echocardiography and Doppler were evaluated in relation to four LV geometric groups (normal, concentric remodeling, eccentric hypertrophy and concentric hypertrophy). Results: No significant difference between the genders was observed regarding the prevalence of the LV geometric groups. Mean values of most evaluated echocardiography and Doppler variables differed between men and women, such as LA, IVS, ...
TY - JOUR. T1 - Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction. AU - Lymperopoulos, Anastasios. AU - Rengo, Giuseppe. AU - Gao, Erhe. AU - Ebert, Steven N.. AU - Dorn, Gerald W.. AU - Koch, Walter J.. PY - 2010/5/21. Y1 - 2010/5/21. N2 - Chronic heart failure (HF) is characterized by sympathetic overactivity and enhanced circulating catecholamines (CAs), which significantly increase HF morbidity and mortality. We recently reported that adrenal G protein-coupled receptor kinase 2 (GRK2) is up-regulated in chronic HF, leading to enhanced CA release via desensitization/down-regulation of the chromaffin cell α2-adrenergic receptors that normally inhibit CA secretion. We also showed that adrenal GRK2 inhibition decreases circulating CAs and improves cardiac inotropic reserve and function. Herein, we hypothesized that adrenal-targeted GRK2 gene deletion before the onset of HF ...
A previous manuscript on this website, SURGICALLY PRODUCED VOLUME AND PRESSURE OVERLOAD HEART FAILURE MODELS IN SWINE, discussed heart failure models that could be produced in swine using selected surgical techniques. Pressure overload hypertrophy is produced by surgical banding of the great vessels of the heart and leads to concentric hypertrophy of the heart. Volume overload hypertrophy of the heart is produced by surgically creating valvular regurgitation or an arteriovenous fistula leading to eccentric hypertrophy of the heart. These conditions lead to different types of heart failure which are reviewed in the previous manuscript. The manuscript also describes the anatomy and physiology of the porcine heart. ...
nontechnical summary Carrying out a myocardial infarction cardiac muscle becomes irreversibly broken and as time passes this may result in heart failure. which this occurs as well as the degree to which adverse remodelling can be attenuated. Abstract Abstract The goal of this research was to research the part of intramyocardial administration of chimeric ephrinA1-Fc in modulating the degree of damage and swelling in non reperfused myocardial infarction (MI). Our outcomes display that intramyocardial shot of 6 μg ephrinA1-Fc in to the boundary zone soon after long term coronary artery ligation in AG-490 B6129s mice led to 50% reduced amount of infarct size 64 much less necrosis 35 less chamber dilatation and 32% less left ventricular free wall thinning at 4 days post-MI. In the infarct zone Ly6G+ neutrophil density was 57% reduced and CD45+ leukocyte density was 21% reduced. Myocyte damage was also reduced in ephrinA1-Fc-treated hearts as evidenced by 54% reduced serum cardiac troponin I. ...
Heart failure progression is accompanied by activation of neurohormonal and cytokine systems as well as a series of adaptive changes within the myocardium, collectively referred to as left ventricular remodelling. The unfavorable alterations may be categorized broadly into changes that occur in the cardiac myocytes and changes that occur in the volume and composition of the extracellular matrix.2 Since remodelling in heart failure is progressive and eventually becomes detrimental, the majority of treatment strategies are aimed at stopping or reversing this process. Although medical management, cardiac resychronization therapy, and long-term or destination mechanical circulatory support have been successful in this regard, a considerable number of patients still progress to end-stage heart failure with limited therapeutic options. For these patients, stem cell therapies are being investigated as a safe treatment strategy for decreasing cardiac remodelling on top of conventional medical and device ...
Lung structural remodelling, characterized by myofibroblast proliferation and collagen deposition, contributes to impaired functional capacity in CHF (congestive heart failure). As the lung is the primary site for the formation of Ang II (angiotensin II), local modifications of this system could contribute to lung remodelling. Rats with CHF, induced following myocardial infarction (MI) via coronary artery ligation, were compared with sham-operated controls. The MI group developed lung remodelling as confirmed by morphometric measurements and immunohistochemistry. Pulmonary Ang II concentrations increased more than 6-fold (P,0.01), and AT1 (Ang II type 1) receptor expression was elevated by 3-fold (P,0.01) with evidence of distribution in myofibroblasts. AT2 (Ang II type 2) receptor expression was unchanged. In isolated lung myofibroblasts, AT1 and AT2 receptors were expressed, and Ang II stimulated proliferation as measured by [3H]thymidine incorporation. In normal rats, chronic intravenous ...
TY - JOUR. T1 - Tissue Inflammation Impairs Tissue-Level Perfusion and Promotes Left Ventricular Remodeling in Patients With Acute Myocardial Infarction. AU - Nishida, Yuya. AU - Itoh, Hiroshi. AU - Iwakura, Katsuomi. AU - Tanaka, Kouji. AU - Kawano, Shigeo. AU - Okamura, Atsunori. AU - Maekawa, Yoshinori. AU - Inoue, Kouichi. AU - Fujii, Kenshi. AU - Hori, Masatsugu. PY - 2005. Y1 - 2005. N2 - Background. C-reactive protein (CRP) level and monocytosis are associated with left ventricular (LV) remodeling in patients with AMI. Methods. One hundred twenty-nine consecutive patients with the first acute myocardial infarction (AMI) underwent myocardial contrast echocardiography (MCE) 2 weeks after successful reperfusion. Results. LV end-diastolic volume index (LVEDVI) at pre-discharge was significantly higher in the no-reflow group than the reflow group (64±17 vs. 58±11 mL/m2, p, 0.01). The no-reflow group had a higher CRP level and peak monocyte counts than the reflow group (9.5±5.2 vs. 5.8±3.5 ...
An effective therapy for chronic myocardial infarction (MI) has yet to be developed. Vascular endothelial growth factor (VEGF) promotes angiogenesis and improves cardiac function after MI. However, non-targeting delivery of VEGF decreases its therapeutic efficacy. In this study, targeting to the nature cardi
Events include all-cause mortality, heart failure(HF)-related urgent care (a healthcare utilization visit involving intravenous(IV) therapy for heart failure) or significant increase(at least 15%) in LVESVI (a measure of the volume of a patients left ventricle) from randomization to a later time point. Time from randomization until the subject experienced one of these events served as the outcome measure. LVESVI endpoints occurred primarily at those visits in which LVESVI measurements were required (6, 12, 18, 24 months). Because endpoints such as death or HF urgent care could occur at any time during follow-up, the subjects outcome measure could range from less than 1 month to 105 months (maximum follow-up duration). Primary endpoints and follow-up data occurring after a subject missed a required LVESVI measurement were excluded from the analysis and the table below. The counts reflect the number of subjects meeting each endpoint, and are not necessarily mutually exclusive ...
Relations of biomarkers representing distinct biological pathways to left ventricular geometry. Circulation. 2008 Nov 25; 118(22):2252-8, 5p following 2258 ...
Anand Pathak, Federica del Monte, Wen Zhao, Jo-El Schultz, John N. Lorenz, Ilona Bodi, Doug Weiser, Harvey Hahn, Andrew Carr, Faisal Syed, Nirmala Mavila, Leena Jha, Jiang Qian, Yehia Marreez, Guoli Chen, Dennis W. McGraw, E. Kevin Heist, J. Luis Guerrero, Anna A. DePaoli-Roach, Roger J. Hajjar and Evangelia G. Kranias ...
Gendenshtein, É.I., Sernov, L.N. Correction of hypersensitivity to strophanthin in experimental myocardial infarction by the action of drugs on the extracardial innervation. Bull Exp Biol Med 91, 769-772 (1981). https://doi.org/10.1007/BF00834362. Download ...
This is a temporary file and hence do not link it from a website, instead link the URL of this page if you wish to link the PDF file ...
The study group comprised 25 patients with STEMI from whom an occlusive thrombus was aspirated from the infarct-related artery with a 7-F catheter. The SOI in the aspirate was determined according to the mean leukocyte count in 5 high-power magnification fields and graded as mild in the presence of ≤100 leukocytes per field or significant if there were ,100 leukocytes per field. The thrombi were categorized as fresh or lytic/organized (L/O) using predefined criteria. Echocardiographic assessment was performed prior to discharge and at 1 year. Adverse left ventricular remodeling (LVR) was defined as a 20% increase in LV end-diastolic volume in comparison with baseline values ...
Figure 1 Kaplan-Meier curves of ventricular arrhythmia-related events (A), death from MI (B), or both end points combined (C). The cumulative incidence of end points is shown in 1,014 patients with an MI and diabetes. Patients were randomly assigned to receive a margarine containing supplemental EPA combined with DHA, a margarine containing supplemental ALA, a margarine containing both EPA-DHA and ALA, or a placebo margarine. P value by log-rank (Mantel-Cox) test. ...
Cardiovascular disease is the leading cause of death in the United States and new treatment options are greatly needed. Oxidative stress is increased following myocardial infarction and levels of antioxidants decrease, causing imbalance that leads to
Heart failure (HF) represents the common endpoint of many different kinds of cardiopulmonary diseases. Essentially, loss of myocardium triggers a sequence of molecular, cellular and physiological responses leading to ventricular remodelling and the inability of the ventricle to maintain an output sufficient for the metabolic requirements of the tissues of the body [1]. Although these responses may be viewed as compensatory in nature, many of them are or become counterregulatory and lead to long-term adverse effects [1]. Thus, novel insight into the regulatory mechanisms that contribute to the compensation and subsequent decompensation is urgently needed to broaden our knowledge about HF and to develop therapeutic strategies that can prevent the progressive deterioration of cardiac function and ultimately avoid this disease. S100 proteins constitute the largest subfamily of EF-hand Ca-binding proteins. Several biological activities, such as the regulation of myocardial and skeletal muscle contractility,
Paging system extension with low delay over fiber optic network. Extend a paging system to a remote zone, connected over fiber optic. The audio must be in sync ...
acizi grasi omega 3 - Dictionar termeni medicali - Acizi grasi care scad fibrinogenul si agregarea plachetara si cresc timpul de sangerare. Alte caracteristici: reduc intinderea zonei de necroza cardiaca post-infarct recent, regularizeaza
Objective: We hypothesised that, compared with culprit-only primary percutaneous coronary intervention (PCI), additional preventive PCI in selected patients with ST-elevation myocardial infarction with multivessel disease would not be associated with iatrogenic myocardial infarction, and would be associated with reductions in left ventricular (LV) volumes in the longer term. Methods: In the preventive angioplasty in myocardial infarction trial (PRAMI; ISRCTN73028481), cardiac magnetic resonance (CMR) was prespecified in two centres and performed (median, IQR) 3 (1, 5) and 209 (189, 957) days after primary PCI. Results: From 219 enrolled patients in two sites, 84% underwent CMR. 42 (50%) were randomised to culprit-artery-only PCI and 42 (50%) were randomised to preventive PCI. Follow-up CMR scans were available in 72 (86%) patients. There were two (4.8%) cases of procedure-related myocardial infarction in the preventive PCI group. The culprit-artery-only group had a higher proportion of anterior ...
The role of IL-6 signalling in hypertensive heart disease and its sequelae is controversial. Our group demonstrated that Bazedoxifene suppressed IL-6/gp130 signalling in cancer cells but its effect on myocardial pathology induced by pressure overload is still unknown. We explored whether Bazedoxifene could confer benefits in wild-type C57BL/6J mice suffering from transverse aortic constriction (TAC) and the potential mechanisms in H9c2 myoblasts. Mice were randomized into three groups (Sham, TAC, TAC+Bazedoxifene, n = 10). Morphological and histological observations suggested TAC aggravated myocardial remodelling while long-term intake of Bazedoxifene (5 mg/kg, intragastric) attenuated pressure overload-induced pathology. Echocardiographic results indicated Bazedoxifene rescued cardiac function in part. We found Bazedoxifene decreased the mRNA expression of IL-6, MMP2, Col1A1, Col3A1 and periostin in murine hearts after 8-week surgery. By Western blot detection, we found Bazedoxifene exhibited ...
Coronary flow reserve (CFR) in the non-infarcted myocardium is often impaired following acute myocardial infarction (AMI). However, the clinical significance of CFR in the non-infarcted myocardium is not fully understood. The objective of the present
TY - JOUR. T1 - Cardiac extracellular matrix remodeling: Fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC). AU - McCurdy, Sarah. AU - Baicu, Catalin F.. AU - Heymans, Stephane. AU - Bradshaw, Amy D.. PY - 2010/3. Y1 - 2010/3. KW - BM-40. KW - Osteonectin. KW - SPARC. KW - Extracellular matrix. KW - Remodeling. KW - Review. U2 - 10.1016/j.yjmcc.2009.06.018. DO - 10.1016/j.yjmcc.2009.06.018. M3 - Article. C2 - 19577572. VL - 48. SP - 544. EP - 549. JO - Journal of Molecular and Cellular Cardiology. JF - Journal of Molecular and Cellular Cardiology. SN - 0022-2828. IS - 3. ER - ...
Myocardial infarction (MI) is a disease of major consequence in the modern world, causing permanent, irreversible damage to the heart. Survivors are at risk for developing further cardiovascular pathologies such as heart failure. Further study of MI injury is crucial to improve the understanding and treatment of the post-MI heart. The most commonly used model for MI in vivo is surgical ligation of the left anterior descending coronary artery (LAD). There are two predominant approaches: permanent ligation (PL), where the LAD is permanently occluded with a suture, or ischaemia-reperfusion (IR), where the LAD is temporarily occluded before removing the suture to restore blood flow and tissue reperfusion. PL results in the majority of the area at risk becoming infarcted, leading to significant apoptotic cell death and a large scar. Conversely, IR salvages some of the area at risk; thus, the scar is smaller and includes reperfusion injury, an additional, albeit smaller, second wave of necrotic damage. PL may
The value of the end systolic volume depends on the arterial blood pressure as well as on the force of ventricular contraction. The arterial blood pressure - especially in the large arteries leaving the heart - is not only pressure outwards against the arterial walls but also back pressure against the aortic valve and the pulmonary valve exerted by the arterial blood. An increased arterial blood pressure results in higher end systolic volume because of more afterload (more resistance to the outflow of blood from the ventricles). Contractility of the ventricular muscle can increase (e.g. from increased stimulation of the heart by the sympathetic nervous system), thereby causing more complete ejection of blood from the ventricle and a resultant lower end systolic volume. ...
Improving patient survival is the ultimate goal after acute myocardial infarction. Although thrombolytics, aspirin, and beta-blockers have greatly decreased mortality, structural changes such as ventricular dilatation evolving within the myocardium during and after acute myocardial infarction indicate a poor prognosis. The Survival and Ventricular Enlargement trial demonstrated that when administered 3 to 16 days after acute myocardial infarction in selected patients, captopril, the angiotensin-converting enzyme inhibitor, reduces ventricular dilatation, prevents the development of congestive heart failure, and reduces morbidity and mortality. This paper reviews results of that trial and presents guidelines for effective captopril dosage after acute myocardial infarction. ...
In hypertensives, left ventricular hypertrophy predicts increased cardiovascular morbidity and mortality. Adding to this burden is abnormality of left ventricular (LV) geometry. Knowledge of the left ventricular geometric patterns in our newly diagnosed hypertensives may have some prognostic significance. One hundred (100) newly diagnosed hypertensives (61males and 39 females) and 78 normotensives (46 males and 32 females) were recruited for the study. All were clinically evaluated and an echocardiographic examination performed. Mean ages for the study subjects and controls were 51.40 ±11.60 and 51.50 ±11.50 years respectively (P = 0.47). Only 24% of the hypertensives had normal geometry with 76% being abnormal. Normal geometry was found in 63% of the controls with 37% being abnormal. Statistical significance was noticed when the geometric patterns of the hypertensive and controls were compared (p value < 0.001). This study showed that only 24% of our hypertensives had normal LV
This study provides new data concerning the performance of current imaging strategies, as well as utility of a novel approach (predicated on a routine echo) for post-MI LV thrombus. There were several key findings. First, LV thrombus remains an important diagnostic issue in the current reperfusion era. Among the broad post-MI population studied, thrombus was present in 8% of all patients, including 15% of those with LAD infarction. Second, although generally associated with adverse remodeling, markedly depressed EF (≤30%) on echo occurred in only 12% of patients with thrombus, and only 18% had an LV aneurysm. Third, despite tailored imaging with uniform contrast administration, echo remained limited as a solitary strategy for post-MI thrombus. Noncontrast echo yielded a diagnostic sensitivity of 35% compared with the reference DE-CMR. Although use of contrast improved echo image quality and sensitivity (64%), one-third of DE-CMR-evidenced thrombi were missed. Fourth, thrombus was strongly ...
Pathogenic remodeling following heart injury is due, in part, to the limited regenerative capacity of adult cardiomyocytes. Cell cycle induction has been recently explored as a therapeutic approach for heart failure, and to this end, expression of cyclin D2 in cardiomyocytes improves outcomes in mouse models follwoing myocardial infarction. In this episode, Gerd Hasenfuß, Loren Field, and Karl Toischer discuss their collaborative effort to further evaluate the effect of increased cyclin D2 on outcomes in response to other forms of heart failure. Cyclin D2 expression improved survival and cardiac function in mice exposed to pressure overload; however, cyclin D2-espressing mice were not protected from adverse effects in response to chronic volume overload. These results support further effort into the development of strategies to improve cardiomyocyte proliferation for some types cardiac injury.. ...
Pathogenic remodeling following heart injury is due, in part, to the limited regenerative capacity of adult cardiomyocytes. Cell cycle induction has been recently explored as a therapeutic approach for heart failure, and to this end, expression of cyclin D2 in cardiomyocytes improves outcomes in mouse models follwoing myocardial infarction. In this episode, Gerd Hasenfuß, Loren Field, and Karl Toischer discuss their collaborative effort to further evaluate the effect of increased cyclin D2 on outcomes in response to other forms of heart failure. Cyclin D2 expression improved survival and cardiac function in mice exposed to pressure overload; however, cyclin D2-espressing mice were not protected from adverse effects in response to chronic volume overload. These results support further effort into the development of strategies to improve cardiomyocyte proliferation for some types cardiac injury.. ...
Pathogenic remodeling following heart injury is due, in part, to the limited regenerative capacity of adult cardiomyocytes. Cell cycle induction has been recently explored as a therapeutic approach for heart failure, and to this end, expression of cyclin D2 in cardiomyocytes improves outcomes in mouse models follwoing myocardial infarction. In this episode, Gerd Hasenfuß, Loren Field, and Karl Toischer discuss their collaborative effort to further evaluate the effect of increased cyclin D2 on outcomes in response to other forms of heart failure. Cyclin D2 expression improved survival and cardiac function in mice exposed to pressure overload; however, cyclin D2-espressing mice were not protected from adverse effects in response to chronic volume overload. These results support further effort into the development of strategies to improve cardiomyocyte proliferation for some types cardiac injury.. ...
Pathogenic remodeling following heart injury is due, in part, to the limited regenerative capacity of adult cardiomyocytes. Cell cycle induction has been recently explored as a therapeutic approach for heart failure, and to this end, expression of cyclin D2 in cardiomyocytes improves outcomes in mouse models follwoing myocardial infarction. In this episode, Gerd Hasenfuß, Loren Field, and Karl Toischer discuss their collaborative effort to further evaluate the effect of increased cyclin D2 on outcomes in response to other forms of heart failure. Cyclin D2 expression improved survival and cardiac function in mice exposed to pressure overload; however, cyclin D2-espressing mice were not protected from adverse effects in response to chronic volume overload. These results support further effort into the development of strategies to improve cardiomyocyte proliferation for some types cardiac injury.. ...
The transcription factor GATA-2 is critical regulator of hematopoietic stem and progenitor cell (HSPC) development and function, and mutations in the enhancer region of GATA2 are linked to blood disorders. In this episode, Emery Bresnick and colleagues develop and characterize a mouse model that harbors a human disease-associated GATA2 enhancer mutation. In this model, hematopoietic development and function were normal unless the animals were exposed to a secondary stress that necessitated blood cell regeneration. The results of this study provide important insight into GATA-2-dependent pathogenesis.. ...
Pathogenic remodeling following heart injury is due, in part, to the limited regenerative capacity of adult cardiomyocytes. Cell cycle induction has been recently explored as a therapeutic approach for heart failure, and to this end, expression of cyclin D2 in cardiomyocytes improves outcomes in mouse models follwoing myocardial infarction. In this episode, Gerd Hasenfuß, Loren Field, and Karl Toischer discuss their collaborative effort to further evaluate the effect of increased cyclin D2 on outcomes in response to other forms of heart failure. Cyclin D2 expression improved survival and cardiac function in mice exposed to pressure overload; however, cyclin D2-espressing mice were not protected from adverse effects in response to chronic volume overload. These results support further effort into the development of strategies to improve cardiomyocyte proliferation for some types cardiac injury.. ...
There are several concerns with this trial (25): 1) the mean (±SD) of diastolic blood pressure in the nifedipine group was 78 ± 11 mm Hg. In patients with chronic severe AR, this measure is very much lower, which suggests that most patients in the nifedipine group did not have severe AR. Moreover, the LV end-diastolic volume index was 94 ± 27 ml/m2, whereas in the Padua trial it was 126 ± 16 ml/m2 (26), which supports that many patients in the Barcelona trial did not have chronic severe AR; 2) there were 32 patients in the nifedipine arm, 7 (22%) dropped out at 2 ± 7 months, thus, only a small number of patients were randomized. In the Padua trial there were 69 patients in the nifedipine group and 4 were lost to follow-up; and 3) there was no change in blood pressure in the Barcelona trial in which nifedipine 20 mg twice a day was given. In the Padua trial, long-acting nifedipine 20 mg was given twice a day, and at the end of the trial there were significant reductions of LV volumes and ...
TY - JOUR. T1 - Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging. AU - Luo, Hanzhi. AU - Mu, Wei Chieh. AU - Karki, Rajendra. AU - Chiang, Hou Hsien. AU - Mohrin, Mary. AU - Shin, Jiyung J.. AU - Ohkubo, Rika. AU - Ito, Keisuke. AU - Kanneganti, Thirumala Devi. AU - Chen, Danica. N1 - Funding Information: We thank R. Vance for discussion and reagents and H. Nolla, A. Valeros, and K. Heydari for cell sorting. Supported by NIH Grants R01 DK101885 (D.C.), R01 DK117481 (D.C.), and AG063404 (D.C.); National Institute of Food and Agriculture (D.C.); PackerWentz Endowment (D.C.); Chau Hoi Shuen Foundation (D.C.); Grants AI124346 (T.-D.K.), AI101935 (T.-D.K.), DK98263 (K.I.), and DK115577 (K.I.); the Leukemia and Lymphoma Society (K.I.); Glenn/AFAR Scholarship (H.L.); Dr. and Mrs. James C.Y. Soong Fellowship (H.-H.C., W.-C.M.); Government Scholarship for Study Abroad (GSSA) from Taiwan (W.-C.M.); NSF ...
As Director of the Cardiac Biology Research Center within the Molecular Cardiology Research Institute at Tufts Medical Center, Dr. Kapurs basic science laboratory focuses on molecular mechanisms governing maladaptive cardiac remodeling in heart failure. His particular expertise involves signaling via the transforming growth factor beta (TGFb) system. Over the past 6 years, the laboratory has published several critical papers focused on a TGFb co-receptor known as endoglin and was the first to establish that reduced endoglin activity improves survival and limits maladaptive cardiac remodeling in heart failure. More recently, the laboratory has demonstrated that targeting endoglin using an antibody-mediated approach not only limits the development of cardiac fibrosis, but can reverse established cardiac fibrosis in preclinical models of heart failure. Dr. Kapur is the recipient of grant funding from the National Institutes of Health, American Heart Association, and several industry sponsors ...
Part 1 - Optimizing navigation for cardiac regenerative therapy In the first part of this thesis we focus on improving navigation strategies for cardiac regenerative therapies. The key point in this part is getting the therapy exactly to the position in the heart where the expected effects are maximal, with ... read more the use of a catheter suitable for intramyocardial injections. In Chapter 2 we describe a method to enable the fusion of MRI images and NOGA maps to optimize intramyocardial injections. Subsequently, in Chapter 3 we use the same approach to retrospectively compare late gadolinium enhanced MRI images with electro-anatomical mapping to find the optimal NOGA parameters to define the infarct border zone. Respiratory induced cardiac motion is an important cause of registration mismatches when fusing two or more imaging modalities. In Chapter 4 we describe a technical solution that enables real-time correction of electro anatomical maps during mapping procedures, in order to reduce ...
Free, official coding info for 2021 ICD-10-CM I97.130 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Accurate and reliable identification of those survivors of acute myocardial infarction who are at high risk of sudden death remain an important and challenging problem. This review summarises the...
Recent evidence suggests that Toll-like receptor4 (TLR4) is not only involved in innate immunity but isalso an important mediator of adverse left…
Recent myocardial infarction is known to be a significant risk factor for postoperative complications following elective, noncardiac surgery
The 60-year-old revealed that he has congestive heart failure following a three-month illness, and asked for followers to send their prayers while he is in the hospital alongside fiancee Romney Snyder.
Ago T, Sadoshima J (November 2006). "Thioredoxin and ventricular remodeling". Journal of Molecular and Cellular Cardiology. 41 ...
These commonly involve surgical left ventricular remodeling. The aim of the procedures is to reduce the ventricle diameter ( ... Tønnessen T, Knudsen CW (August 2005). "Surgical left ventricular remodeling in heart failure". Eur. J. Heart Fail. 7 (5): 704- ... "Surgical ventricular restoration in the treatment of congestive heart failure due to post-infarction ventricular dilation". J. ... CRT: People with NYHA class III or IV, left ventricular ejection fraction (LVEF) of 35% or less and a QRS interval of 120 ms or ...
Tønnessen T, Knudsen CW (August 2005). "Surgical left ventricular remodeling in heart failure". Eur. J. Heart Fail. 7 (5): 704- ... ventricular mass may result in superior geometric remodeling thus conferring better performance when faced with ventricular ... was an experimental heart procedure that proposed the reversal of the effects of remodeling in cases of end-stage dilated ...
"Right ventricular reverse remodelling after balloon pulmonary angioplasty". The European Respiratory Journal. 43 (5): 1394-1402 ... based on data showing haemodynamic improvement and recovery of right ventricular function. Research is ongoing. Historically ...
Kloner RA, Shi J, Dai W (February 2015). "New therapies for reducing post-myocardial left ventricular remodeling". Annals of ...
Cooper GN (2006). "Left ventricular remodeling or restoration for congestive heart failure". Med Health R I. 89 (1): 36-8. PMID ... of the septum and ventricular wall and would prove to be the best option amongst the other methods of ventricular remodeling, i ... To begin a basic remodeling, the surgeon makes an incision at the center of the depressed area on the LV wall and removes blood ... The surgeon then inserts a balloon into the ventricular cavity to ensure correct size and sutures a Dacron patch, deflating the ...
... right ventricular remodeling is associated with increased apoptosis; this is in contrast to pulmonary vascular remodeling which ... Pulmonary hypertension secondary to left heart disease Left ventricular systolic dysfunction Left ventricular diastolic ... If it is caused by left heart disease, the treatment is to optimize left ventricular function by the use of medication or to ... The right ventricle is normally part of a low pressure system, with systolic ventricular pressures that are lower than those ...
It addresses the ventricular remodeling that occurs in this condition. The device is a set of three to five paired anchors that ...
Doughty, Robert N.; Whalley, Gillian A.; Gamble, Greg; MacMahon, Stephen; Sharpe, Norman (1997). "Left Ventricular Remodeling ... "Effects of Carvedilol on Left Ventricular Remodeling After Acute Myocardial Infarction". Circulation. 109 (2): 201-206. doi: ... Her 1998 MSc Selection bias and confounding associated with echocardiographic estimation of left ventricular mass was followed ... "Selection bias and confounding associated with echocardiographic estimation of left ventricular mass". catalogue.library. ...
Over time, this increased workload causes left ventricular hypertrophy and left ventricular remodelling, which can lead to ... Cheng, S.; Vasan, R. S. (2011). "Advances in the Epidemiology of Heart Failure and Left Ventricular Remodeling". Circulation. ...
This results in a rapid decrease in central blood volume and a reduction of ventricular preload which in turn reduces stroke ... In the longer term a process termed remodeling also contributes to changing the caliber of small blood vessels and influencing ... Mulvany, Michael J. (2012). "Small artery remodelling in hypertension". Basic & Clinical Pharmacology & Toxicology. 110 (1): 49 ... which is a major determinant of right ventricular end diastolic volume. (However, there can be exceptions in some cases.)[36] ...
Ventricular remodeling. Vascular system/. Hemodynamics. Blood flow. *Compliance. *Vascular resistance. *Pulse. *Perfusion ...
Fox K, Ford I (2008). "Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular ... Salerno DM, Zanetti J (1991). "Seismocardiography for monitoring changes in left ventricular function during ischemia". Chest. ... "Resting heart rate and risk of sudden cardiac death in the general population: influence of left ventricular systolic ...
... or ventricular fibrillation VF (VF) in the future. Sometimes a series of EPS drug trials must be conducted to enable the ... regimens in order to assess the likelihood that the regimen will successfully prevent potentially fatal sustained ventricular ...
The 'U' wave is a wave on an electrocardiogram (ECG). It comes after the T wave of ventricular repolarization and may not ...
... must be specified as atrial or ventricular (e.g., the ventricular rate in ventricular fibrillation is 300-600 bpm, whereas the ... Ventricular reduction. Alcohol septal ablation. Conduction system. Maze procedure Cox maze and minimaze. Catheter ablation ... or ventricular rhythms such as ventricular tachycardia. Metabolic issues such as severe hyperkalemia, or tricyclic ... Sine wave pattern is the hallmark of ventricular flutter. *Absent P waves with wide QRS complexes and a fast heart rate is ...
... implications in cardiovascular remodeling". Current Opinion in Nephrology and Hypertension. 17 (2): 168-73. doi:10.1097/MNH. ... it may be involved in remodeling or vascular tone; and in the brain, where it is largely independent of the circulatory RAS, it ...
... ventricular tachycardia). Some tachyarrhythmias are caused by scarring within the heart (e.g. some forms of ventricular ... Further development will include the septa and valves formation and remodelling of the heart chambers. By the end of the fifth ... A third heart sound, S3 usually indicates an increase in ventricular blood volume. A fourth heart sound S4 is referred to as an ... In very severe cases of heart failure, a small pump called a ventricular assist device may be implanted which supplements the ...
With either of these rhythms, if the ventricular rate is fast, the fibrillatory or flutter waves can easily be misinterpreted ...
November 2015). "Dominant negative Ras attenuates pathological ventricular remodeling in pressure overload cardiac hypertrophy ...
"Computational method for identifying and quantifying shape features of human left ventricular remodeling". Annals of Biomedical ... "Atlas Generation for Subcortical and Ventricular Structures with its Applications in Shape Analysis". IEEE Transactions on ... "Baseline Shape Diffeomorphometry Patterns of Subcortical and Ventricular Structures in Predicting Conversion of Mild Cognitive ...
Dec 2009). "Impact of cardiac contractility modulation on left ventricular global and regional function and remodeling". JACC ... May 2007). "Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling ... Other irregular rhythms, including frequent premature ventricular contractions (ventricular extra systoles) or a distinct ... The short- and long-term use of this therapy enhances the strength of ventricular contraction and therefore the heart's pumping ...
Further studies using right ventricular epicardial systolic strain and geometric remodeling analysis in these animals unveiled ... "Deficiency of actinin-associated LIM protein alters regional right ventricular function and hypertrophic remodeling". Annals of ... ALP functions to enhance the crosslinking of actin by alpha actinin-2 and also appears to be essential for right ventricular ... that absence of ALP diminishes right ventricular contractile function and alters the pattern of cardiac hypertrophic remodeling ...
"Identification of candidate genes potentially relevant to chamber-specific remodeling in postnatal ventricular myocardium". ...
They also reported that inhibition of the TGF-β1 receptor may also prevent ventricular remodeling. Effects of oxymatrine on ... and ventricular remodeling in a manner that promotes dysfunction. The mechanism by which oxymatrine may inhibit fibrosis is ... on ventricular remodeling in spontaneously hypertensive rats. Phytomedicine 20: 202-212. Levy, L, Hill, CS. (2006). Alterations ... Alterations in G protein and MAP kinase signaling pathways during cardiac remodeling in hypertension and heart failure. ...
"Reduced expression of Cx43 attenuates ventricular remodeling after myocardial infarction via impaired TGF-β signaling". ... Additionally, reduced Cx43 expression in vascular tissue, which plays a part in ventricular remolding and healing of wounds ...
"Reduced expression of Cx43 attenuates ventricular remodeling after myocardial infarction via impaired TGF-beta signaling". Am. ... May 2006). "Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response". J. Clin. Invest. ...
Pelliccia, A: Remodeling of Left Ventricular Hypertrophy in Elite Athletes After Long-Term Deconditioning, Circulation. 2002; ... The goal is avoidance of infarction, heart failure, and/or lethal arrhythmias (ventricular tachycardia, ventricular ... and despite some theoretical concerns that the ventricular remodeling might conceivably predispose for serious arrhythmias, no ... Both static and dynamic exercises involve the thickening of the left ventricular wall due to increased cardiac output, which ...
... has also been associated as a factor promoting ventricular remodeling following mitral valve repair, and may ... September 2013). "Galectin-3 and left ventricular reverse remodelling after surgical mitral valve repair". European Journal of ... and ventricular remodeling. Galectin-3 associates with the primary cilium and modulates renal cyst growth in congenital ... Yan YP, Lang BT, Vemuganti R, Dempsey RJ (September 2009). "Galectin-3 mediates post-ischemic tissue remodeling". Brain ...
... ventricular hypertrophy[132] and heart failure.[133] Additionally, evidence is accumulating that the UPS plays an essential ... "Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome" ...
"Recovery of learning and memory is associated with chromatin remodelling". primary. Nature. 447 (7141): 178-82. Bibcode: ... IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and ...
... and left ventricular hypertrophy, characteristic of chronic hypertension. All atrial remodeling is related to heterogeneous ... remodeling) in the atria and ventricles of the heart.[32] This remodeling leads to abnormally increased pressure in the left ... left ventricular size and function, peak right ventricular pressure (pulmonary hypertension), presence of left atrial thrombus ... Lower heart rates may be recommended in those with left ventricular hypertrophy or reduced left ventricular function.[110] Rate ...
Veno-occlusive remodelling[edit]. This theory proposes how high pulmonary venous pressures may lead to the capillary rupture ... slow left ventricular relaxation time, right tricuspid valve regurgitation), preferential distribution of blood flow to the ... Other histopathologic findings include fibrosis, bronchial artery neovascularization, venous remodeling, bronchiolitis, ... with the venous remodeling leading to regional vascular congestion and hemorrhage, hemosiderin accumulation, fibrosis, and ...
Catecholaminergic polymorphic ventricular tachycardia. References[edit]. *^ Katz, Arnold M. (2005). Physiology of the Heart ( ... GeneReviews/NCBI/NIH/UW entry on Catecholaminergic Polymorphic Ventricular Tachycardia. *Calsequestrin at the US National ... A lack of or mutation in CSQ2 has been directly associated with catecholamine-induced polymorphic ventricular tachycardia (CPVT ...
Left ventricular end diastolic posterior wall dimension. LVPWd. The thickness of the posterior left ventricular wall.. 8.3 mm,[ ... Right ventricular pressure demonstrates a different pressure-volume loop than left ventricular pressure.[11] ... also called ventricular extra beats. When these beats become grouped the condition is known as ventricular tachycardia. ... Left ventricular end-diastolic dimension. LVEDD or sometimes LVDD. The end-diastolic dimension of the left ventricle.. 48 mm,[ ...
In 2013, studies of autologous bone marrow stem cells on ventricular function were found to contain "hundreds" of discrepancies ... supporting tissue remodeling over scar formation, 4) inhibiting apoptosis, and 5) differentiating into bone, cartilage, tendon ... of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular ...
Review (including references) of piezoelectricity and bone remodelling. *A good basic overview of bone biology from the Science ... মস্তিষ্কগহ্বর ব্যবস্থা (Ventricular system) *আবরণীবৎ জালিকা (Choroid plexus). *স্নায়ুকোষ (Neuron). *স্নায়ু অক্ষ (Axon) ...
Ventricular hypertrophy, the thickening of the ventricular walls, is generally beneficial and healthy if it occurs in response ... "Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training". Circulation. 123 (1): 13-22. doi: ...
With support from collagen, atrial fibrillation should never deteriorate to ventricular fibrillation. Collagen is layered in ... Collagenase, the enzyme involved in collagen breakdown and remodeling. *Hypermobility syndrome. *MMP inhibitors ...
The blockade of only beta receptors increases blood pressure, reduces coronary blood flow, left ventricular function, and ... and abnormal cardiac tissue remodeling, all of which decrease the efficiency of cardiac contraction and contribute to the low ... Atenolol, metoprolol (immediate release), propranolol (immediate release), timolol, carvedilol (after left ventricular ...
Left ventricular hypertrophy and left ventricular remodeling[5]. *Diminished coronary flow reserve and silent myocardial ... Left ventricular hypertrophy in athletes. *Congestive heart failure or heart failure with normal ejection fraction due to other ... Maeder MT, Kaye DM (March 2009). "Heart failure with normal left ventricular ejection fraction". Journal of the American ... Kannel WB, Cobb J (1992). "Left ventricular hypertrophy and mortality-results from the Framingham Study". Cardiology. 81 (4-5 ...
Ventricular remodeling. Dalerayan[mag-edit , alilan ya ing pikuwanan]. *↑ (2004) The World Health Report 2004 - Changing ... Ventricular tachycardia) - Atrial fibrillation - Atrial flutter - Premature contraction (Atrial, Ventricular) - Sick sinus ... Heart failure - Cardiomegaly - Ventricular hypertrophy (Left, Right). Arteries, arterioles and capillaries. Atherosclerosis - ... Arrhythmogenic right ventricular dysplasia. Electrical conduction system of the heart. AV block (First degree, Second degree, ...
"A meta-analysis of the effect of exercise training on left ventricular remodeling in heart failure patients: the benefit ...
regulation of tissue remodeling. • negative regulation of gene expression. • positive regulation of ERK1 and ERK2 cascade. • ... Srivastava D, Gottlieb PD, Olson EN (2003). "Molecular mechanisms of ventricular hypoplasia". Cold Spring Harbor Symposia on ... "A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart". Development. 127 (24): 5331- ... which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. ...
... ventricular tachycardia, and more recently as management of atrial fibrillation. The term is often used in the context of laser ... laser is used to remodel the cornea refractive properties to correct refraction errors, such as astigmatism, myopia, and ...
blood vessel remodeling. • secondary heart field specification. • regulation of cell proliferation. • positive regulation of ... ventricular trabecula myocardium morphogenesis. • negative regulation of ossification. • positive regulation of cell ...
It contributes to ventricular remodeling and ventricular hypertrophy of the heart through stimulation of the proto-oncogenes c- ... Patients with heart failure may benefit from the combination in terms of reducing morbidity and ventricular remodeling.[61][62] ... "Changes in Ventricular Size and Function in Patients Treated with Valsartan, Captopril, or Both After Myocardial Infarction". ...
Left ventricular hypertrophy, for example, increases an individual's chance of sudden death due to a ventricular arrhythmia ... "Effect of Left Ventricular Hypertrophy and Its Regression on Ventricular Electrophysiology and Vulnerability to Inducible ... 3.3 Current research on REST/NRSF and ventricular hypertrophy in mammals. *3.4 Mutations in polycomb-group response elements ( ... Current research on REST/NRSF and ventricular hypertrophy in mammals[edit]. See also: Atrial natriuretic peptide ...
... s are found in both atrial and ventricular cardiac muscle cells (cardiomyocytes), in which they develop in the first ... as some suggest that T-tubule remodelling might be reversed through the use of interval training.[5] ... "Excitation-contraction coupling in rat ventricular myocytes after formamide-induced detubulation". Am J Physiol. 277(2): H603-9 ... While early work focussed on ventricular cardiac muscle and skeletal muscle, in 2009 an extensive T-tubule network in atrial ...
Tan NY, Leong YY, Lang SS, Htoon ZM, Young SM, Sundar G (May 2017). "Radiologic Parameters of Orbital Bone Remodeling in ... and premature ventricular contractions, and hypertension.[7] People with hyperthyroidism may experience behavioral and ... and progressive remodeling of the orbital walls.[21][22][23] Other distinctive features of TAO include lid retraction, ...
"Reduced expression of Cx43 attenuates ventricular remodeling after myocardial infarction via impaired TGF-beta signaling". Am. ... "Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response". J. Clin. Invest. 116 (5): ...
Todd, MM; Dunlop, BJ; Shapiro, HM; Chadwick, HC; Powell, HC (1981). "Ventricular fibrillation in the cat: A model for global ... "Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity" ...
Ventricular remodeling may include ventricular hypertrophy, ventricular dilation, cardiomegaly, and other changes. It is an ... In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of ... Physiological remodeling is reversible while pathological remodeling is mostly irreversible. Remodeling of the ventricles under ... Ventricular+remodeling at the US National Library of Medicine Medical Subject Headings (MeSH) Yu, Cheuk-Man; Bleeker, Gabe B.; ...
This article examines the relationship between LV remodeling and clinical outcomes of heart failure syn ... remodeling has led to greater knowledge of the pathophysiology of heart failure syndrome. ... An understanding of the process of left ventricular (LV) ... An understanding of the process of left ventricular (LV) ... It is also demonstrated that drug therapies that slow or reverse the remodeling process appear to have favorable natural ...
97 Men and Women differ in their Adaptation to Aortic Stenosis and in Reverse Remodelling following Aortic Valve Intervention ...
Ventricular Reversed Remodeling After LTX in PAH Patients (PAH-LTX). The safety and scientific validity of this study is the ... Ventricular remodeling on cardiac magnetic resonance [ Time Frame: Six months postoperative ]. Absolute decrease in RV end- ... Ventricular remodeling on cardiac magnetic resonance [ Time Frame: Six months postoperative ]. Absolute increase in LV end- ... Ventricular remodeling on cardiac magnetic resonance [ Time Frame: Six months postoperative ]. Decrease in LV end-systolic ...
... ventricular remodeling include Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 ... Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice ... Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR, Isolation of ... A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats, Myocardial Infarction in Neonatal Mice, A ...
In this review, passive ventricular remodeling is described in Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM ... In this review, passive ventricular remodeling is described in Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM ... Besides that, it also includes molecular remodeling of gap junctions, especially those composed by Connexin43 proteins (Cx43) ... Besides that, it also includes molecular remodeling of gap junctions, especially those composed by Connexin43 proteins (Cx43) ...
"Ventricular Remodeling" by people in Harvard Catalyst Profiles by year, and whether "Ventricular Remodeling" was a major or ... "Ventricular Remodeling" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Insulin Resistance Modifies the Effects of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial ... Below are the most recent publications written about "Ventricular Remodeling" by people in Profiles. ...
Early Short-Term Treatment With Doxycycline Modulates Postinfarction Left Ventricular Remodeling. Francisco J. Villarreal, ... Early Short-Term Treatment With Doxycycline Modulates Postinfarction Left Ventricular Remodeling. Francisco J. Villarreal, ... Early Short-Term Treatment With Doxycycline Modulates Postinfarction Left Ventricular Remodeling. Francisco J. Villarreal, ...
Background: Left ventricular remodeling (LVR) after myocardial infarction is associated with an increased risk of heart failure ... Expression and Implication of Clusterin in Left Ventricular Remodeling After Myocardial Infarction Circ Heart Fail. 2018 Jun;11 ...
This remodeling consists of cardiomyocyte hypertrophy and changes in the amount of collagen, collagen phenotype and collagen ... Elevations in myocardial stress initiate structural remodeling of the heart in an attempt to normalize the imposed stress. ... The relationship between myocardial extracellular matrix remodeling and ventricular function Eur J Cardiothorac Surg. 2006 Oct; ... This remodeling consists of cardiomyocyte hypertrophy and changes in the amount of collagen, collagen phenotype and collagen ...
Ventricular Remodeling. Hypertrophy, Left Ventricular. Vascular Diseases. Cardiovascular Diseases. Pathological Conditions, ... The SILVER Study: Systolic Hypertension Interaction With Left Ventricular Remodeling. This study has been completed. ... Patients with left ventricular hypertrophy (LVH) as determined by limited echocardiography for LVH (i.e., wall thickness , 1.2 ... A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys. Proc Natl Acad Sci U ...
Remodeling of Left Ventricular Hypertrophy in Elite Athletes After Long-Term Deconditioning. Antonio Pelliccia, Barry J. Maron ... Remodeling of Left Ventricular Hypertrophy in Elite Athletes After Long-Term Deconditioning ... Remodeling of Left Ventricular Hypertrophy in Elite Athletes After Long-Term Deconditioning ... Remodeling of Left Ventricular Hypertrophy in Elite Athletes After Long-Term Deconditioning ...
Ventricular Remodeling Operation (Batista Procedure). The ventricular remodeling operation (also known as the Batista procedure ... Diastolic ventricular support with cardiac support devices: An alternative approach to prevent adverse ventricular remodeling. ... Ventricular restoration -- a surgical approach to reverse ventricular remodeling. Heart Fail Rev. 2004;9(4):233-239; discussion ... Surgical ventricular restoration procedure, includes prosthetic patch, when performed (eg, ventricular remodeling, SVR, SAVER, ...
Left Ventricular Strain and Transmural Distribution of Structural Remodeling in Hypertensive Heart Disease. Tomoko Ishizu, ... Left Ventricular Strain and Transmural Distribution of Structural Remodeling in Hypertensive Heart Disease ... Left Ventricular Strain and Transmural Distribution of Structural Remodeling in Hypertensive Heart Disease ... Left Ventricular Strain and Transmural Distribution of Structural Remodeling in Hypertensive Heart Disease ...
Ventricular remodeling in global ischemia. Cardioscience. 1995 Jun; 6(2):89-100. ...
Tricuspid Regurgitation Does Not Impact Right Ventricular Remodeling After Percutaneous Pulmonary Valve Implantation. Download ... RightVentricular Function, RightVentricular Outflow ObstructionVentricular RemodelingYoung Adult ... Right ventricular remodelling after transcatheter pulmonary valve implantation.. *Percutaneous pulmonary valve implantation: 5 ... Tricuspid Regurgitation Does Not Impact Right Ventricular Remodeling After Percutaneous Pulmonary Valve Implantation.. JACC ...
... remodeling on anterior and posterior mitral leaflet (AML and PML) tethering in ischemic mitral regurgitation (MR) has not been ... BACKGROUND: Different influences of left ventricular (LV) remodeling on anterior and posterior mitral leaflet (AML and PML) ... CONCLUSIONS: LV remodeling augments tethering of both AML and PML, with greater influence on PML. ... To examine different influences of LV remodeling on AML and PML tethering, interaction between AML/PML and LV sphericity was ...
Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L- ... Left ventricular volumes and ejection fraction were evaluated on admission, at discharge from hospital and at 3, 6 and 12 ... This study was performed to evaluate the effects of L-carnitine administration on long-term left ventricular dilation in ... A significant attenuation of left ventricular dilation in the first year after acute myocardial infarction was observed in ...
... role of perivascular inflammation in coronary artery remodeling and cardiac fibrosis during hypertrophic ventricular remodeling ... accumulation and altered subsequent coronary artery remodeling. The contribution of lymphocytes were examined in Rag1−/− mice, ... Left ventricular hypertrophy (LVH) is usually accompanied by intensive interstitial and perivascular fibrosis, which may ...
Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta- ... RVID: right ventricular basal diameter measured at end-diastole; RVWT: right ventricular wall thickness; RV MPI: right ... RVID: right ventricular basal diameter measured at end-diastole; RVWT: right ventricular wall thickness; RV MPI: right ... 3.3.1. RV Remodeling. To evaluate RV structure, RVID and RVWT were assessed. Changes in RVID were reported in 16 studies (22 ...
Surgical ventricular remodeling, or SVR, is a procedure that reshapes and restores efficiency to hearts that have become ... Surgical Ventricular Remodeling. Surgical ventricular remodeling, or SVR, is a procedure that reshapes and restores efficiency ... to hearts that have become weakened and enlarged (left ventricular aneurysm), often due to a heart attack. Tissue damage ...
Sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while ... either of atrial or of ventricular origin, remains a major challenge. ... Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias. ... The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden ...
Montefiore Einstein Center for Heart and Vascular Care is a national leader in surgical ventricular reconstruction. SVR has a ... Ventricular Remodeling Surgery (SVR). Surgical Ventricular Reconstruction (SVR). Surgical ventricular reconstruction (SVR) ... Surgical Ventricular Reconstruction. At the start of the SVR procedure, the surgeon will make an incision into the heart to ... Montefiore Einstein Center for Heart and Vascular Care is a national leader in surgical ventricular reconstruction. SVR has a ...
Left Ventricular Remodeling and Clinical Outcomes in Patients with Chronic Kidney Impairment. Circulation. 2019 Nov 29;: ... Coronary Microvascular Dysfunction, Left Ventricular Remodeling and Clinical Outcomes in Patients with Chronic Kidney ... Coronary Microvascular Dysfunction, Left Ventricular Remodeling and Clinical Outcomes in Patients with Chronic Kidney ...
Remodeling was defined as an at least 10% increase from baseline in the left ventricular end-diastolic volume. Plasma miRNA ... Results showed that levels of plasma miR-208b and miR-34a were significantly higher in patients with remodeling than those ... demonstrated that circulating miR-208b and miR-34a could be useful biomarkers for predicting left ventricular remodeling after ... myocardial remodeling and progression to heart failure. In the present study, a total of 359 consecutive patients were ...
"Ventricular Remodeling" by people in this website by year, and whether "Ventricular Remodeling" was a major or minor topic of ... Surgical ventricular reconstruction has a role in surgical remodeling in patients with LV systolic dysfunction even post-STICH ... "Ventricular Remodeling" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Adverse structural remodeling of the left ventricle and ventricular arrhythmias in patients with depressed ejection fraction. J ...
Association between mutation status and left ventricular reverse remodelling in dilated cardiomyopathy ... Association between mutation status and left ventricular reverse remodelling in dilated cardiomyopathy ... assessing the possible relation between different genotypes and left ventricular reverse remodelling (LVRR). ... LVRR was defined by left ventricular ejection fraction normalisation or increase ≥10% associated with normalisation in indexed ...
"Ventricular reconstruction results in improved left ventricular function and amelioration of mitral insufficiency". Ann Surg . ... Cardiac transplantation is usually preferred over ventricular remodeling for patients with end-stage ischemic cardiomyopathy ... Close more info about Left Ventricular Aneurysm Resection and Remodeling (Dor Procedure) ... Close more info about Left Ventricular Aneurysm Resection and Remodeling (Dor Procedure) ...
Introduction The main impact of myocardial infarction is shifting from acute mortality to adverse remodeling and chronic left ... Circulating biomarkers as predictors of left ventricular remodeling after myocardial infarction. Michał Węgiel ... Węgiel M, Rakowski T. Circulating biomarkers as predictors of left ventricular remodeling after myocardial infarction. Advances ... Węgiel, M., and Rakowski, T. (2021). Circulating biomarkers as predictors of left ventricular remodeling after myocardial ...
Perindopril, Bisoprolol Not Effective for Preventing Trastuzumab-mediated Left Ventricular Remodeling. Share this content: * ... but did not prevent therapy-mediated left ventricular remodeling, a study published in the Journal of Clinical Oncology has ... Results showed that indexed left ventricular end diastolic volume increased in all 3 groups (P =.36). Investigators found that ... Patients underwent cardiac MRI at baseline and after cycle 17 of treatment for the determination of left ventricular volumes ...
  • Coronary Microvascular Dysfunction, Left Ventricular Remodeling, and Clinical Outcomes in Patients With Chronic Kidney Impairment. (harvard.edu)
  • If continued elevations in wall stress exceed the ability of the heart to compensate, then the ventricular wall thickness is disproportionately reduced compared to chamber volume and diastolic and systolic dysfunction ensues. (nih.gov)
  • PPVI provides a less invasive alternative to surgery in patients with right ventricular-to-pulmonary artery (RV-PA) conduit dysfunction. (unboundmedicine.com)
  • Furthermore, pulmonary hypertension in OSA patients can lead to the development of right ventricular (RV) hypertrophy and dysfunction. (hindawi.com)
  • The Dor procedure is generally contraindicated in patients with right ventricular dysfunction, pulmonary hypertension, systolic pulmonary hypertension greater than 60 mm Hg (in the absence of concomitant MR), and LV dysfunction at the base of the heart. (oncologynurseadvisor.com)
  • The main impact of myocardial infarction is shifting from acute mortality to adverse remodeling and chronic left ventricle dysfunction. (termedia.pl)
  • Aldosterone antagonism has been studied in patients with advanced heart failure (HF) and also in patients with post-myocardial infarction and left ventricular (LV) dysfunction with HF symptoms. (unboundmedicine.com)
  • In a clinically stable, well-treated population of patients with mild-to-moderate HF symptoms and LV dysfunction, 36 weeks of treatment of aldosterone antagonism with eplerenone at a dose of 50 mg daily had no detectable effect on parameters of LV remodeling. (unboundmedicine.com)
  • Taken together, these data indicate that, after MI, TRPV1 afferent-induced adrenergic dysfunction promotes fibrosis and adverse cardiac remodeling, and it worsens border zone electrical heterogeneity, resulting in electrically unstable ventricular myocardium. (jci.org)
  • These cardiac abnormalities, including left ventricular hypertrophy and systolic dysfunction, are common in hemodialysis and are associated with an increased risk of adverse clinical outcomes (4) . (onlinejacc.org)
  • Myocardial fibrosis, a characteristic of all forms of cardiac pathology, leads to mechanical stiffness, which contributes to ventricular contractile dysfunction [ 4 ]. (medsci.org)
  • Myocardial infarction can lead to ventricular remodeling ( [1] ) with compensatory dilation and hypertrophy and subsequent systolic and diastolic dysfunction progressing to the clinical syndrome of congestive heart failure. (onlinejacc.org)
  • Even if the ventricular dysfunction as a result of the infarct is not immediately life-threatening, a common sequela of a transmural myocardial infarction in the left ventricle is heart failure brought about by ventricular remodeling. (google.com)
  • Microvascular obstruction remains a portent of adverse remodeling in optimally treated patients with left ventricular systolic dysfunction after acute myocardial infarction. (druglib.com)
  • A total of 1116 patients with left ventricular dysfunction following the first episode of acute ST-elevation MI are to be enrolled and randomized to a maximal tolerable dose (up to 320 mg/day) or usual dose (80 mg/day) of valsartan for 12 months in 2:1 ratio. (biomedcentral.com)
  • The literature on right ventricular systolic dysfunction (RVSD) in peripartum cardiomyopathy (PPCM) patients is scanty, and it appears that RV reverse remodelling in PPCM has not been previously described. (biomedcentral.com)
  • We previously described right ventricular (RV) systolic dysfunction in PPCM patients using tricuspid annular plane systolic excursion (TAPSE), and reported RV systolic dysfunction (RVSD) in 54.6 % of the patients [ 3 ]. (biomedcentral.com)
  • We conclude that VSEL-SCs expanded in culture retain the ability to alleviate LV dysfunction and remodelling after a reperfused MI provided that they are exposed to a combination of cardiomyogenic growth factors and cytokines prior to transplantation. (elsevier.com)
  • These data may provide an explanation of progressive late left ventricular dysfunction. (units.it)
  • Therefore, an increase in hemodynamic stress combined with diabetes leads to greater myocyte loss and impaired hypertrophic response resulting in adverse LV remodeling and accelerating the progression of contractile dysfunction and heart failure. (grantome.com)
  • Ventricular remodeling is characterized by progressive chamber dilatation, wall thinning, and systolic/diastolic dysfunction [142] beginning days after MI and persisting for weeks and months after the initial insult both at the site of MI and in the healthy myocardium [120, 143-146]. (americorpshealth.biz)
  • Apoptosis contributes to ventricular remodeling and heart failure not only through a reduction of the contractile cell mass, but probably also through another mechanism: activated caspases can cleave contractile proteins, such as actin, myosin, and troponin, leading to contractile dysfunction [1, 147]. (americorpshealth.biz)
  • Evaluating global myocardial function by stress echocardiography is crucial to distinguish between adaptive or maladaptive LV remodeling in patients with LV systolic dysfunction. (biomedcentral.com)
  • The changes may progress for weeks and months after MI and lead to worsening left ventricular dilation and systolic dysfunction, HF symptoms, need for hospitalization, and premature death ( Figure 36-1 ). (thoracickey.com)
  • Left ventricular volumes and ejection fraction were evaluated on admission, at discharge from hospital and at 3, 6 and 12 months after acute myocardial infarction. (nih.gov)
  • No significant differences were observed in left ventricular ejection fraction changes over time in the two groups. (nih.gov)
  • Adverse structural remodeling of the left ventricle and ventricular arrhythmias in patients with depressed ejection fraction. (umassmed.edu)
  • LVRR was defined by left ventricular ejection fraction normalisation or increase ≥10% associated with normalisation in indexed left ventricular end-diastolic diameter or relative decrease ≥10% at 24 months follow-up. (bmj.com)
  • Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, and the beta blocker bisoprolol protected against trastuzumab-related declines in left ventricular ejection fraction (LVEF) but did not prevent therapy-mediated left ventricular remodeling, a study published in the Journal of Clinical Oncology has shown. (oncologynurseadvisor.com)
  • 9 ) showed that patients with larger MIs, as evidenced by greater elevations in serum creatine kinase concentrations, manifest greater 90-day increases in LV end-diastolic volume (EDV) and greater reductions in left ventricular ejection fraction (LVEF) ( Fig. 1 ). (onlinejacc.org)
  • 8 ) relate echocardiographic patterns of LV remodeling an average of 5 days after MI associated with heart failure (HF), left ventricular ejection fraction ≤35%, or both, to the incidence of subsequent CV events. (onlinejacc.org)
  • Beta-adrenergic blocking drugs have been shown to improve left ventricular ejection fraction in patients with heart failure due to either ischemic heart disease or idiopathic dilated cardiomyopathy. (onlinejacc.org)
  • left ventricular end-systolic volume index was 15.3 ml/m 2 less (p = 0.0001), and left ventricular ejection fraction was 5.8% greater (p = 0.0015). (onlinejacc.org)
  • In patients with heart failure due to ischemic heart disease, carvedilol therapy for 12 months reduced left ventricular volumes, increased left ventricular ejection fraction and prevented progressive left ventricular dilation. (onlinejacc.org)
  • Six months after the STEMI patients with VR had lower left ventricular ejection fraction, and higher end systolic and diastolic volume. (alliedacademies.org)
  • The plasma level of catestatin correlated with anterior AMI and left ventricular ejection fraction (LVEF) in the acute stage. (bmj.com)
  • Left ventricular remodeling was initiated regardless of preoperative left ventricular ejection fraction or PPM. (avhandlingar.se)
  • BACKGROUND: Microvascular obstruction (MO) is associated with large acute myocardial infarction and lower left ventricular (LV) ejection fraction and predicts greater remodeling, but whether this effect is abolished by contemporary antiremodeling therapies is subject to debate. (druglib.com)
  • After pulmonary valve replacement, the right ventricular ejection fraction did not change significantly (46% versus 42%, p = 0.337). (springer.com)
  • The data including Left Ventricular (LV) Systolic Wall Thickening (WT), Wall Thickening Rate (WTR), Wall Motion Score (WM) and Ejection Fraction (EF) were analysed by Argus software. (alliedacademies.org)
  • It is able to assess wall thickening of Left Ventricular Systolic (WT), Ejection Fraction (EF), Wall Motion (WM) and contraction and relaxation of overall or regional quantitatively [ 8 ]. (alliedacademies.org)
  • This study tested the effect of obesity reduction on preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice. (biomedcentral.com)
  • Serial transthoracic and transesophageal echocardiograms were performed before surgery, after 6 months and after 12 months to assess grade of MR, left ventricular and left atrial remodeling, left ventricle ejection fraction. (biomedcentral.com)
  • Aims Cardiac resynchronization therapy (CRT) is a well established therapy in heart failure patients who are on optimal medical therapy and have reduced left ventricular ejection fraction (LVEF) and wide QRS complexes. (elsevier.com)
  • We sought to test whether ESE parameters are useful to identify the risk of adverse left ventricular (LV) remodeling in patients with chronic HF and reduced or mildly reduced LV ejection fraction (EF). (biomedcentral.com)
  • Results: Six clinical remodeling indices (end-diastolic volume index, sphericity, relative wall thickness, ejection fraction, apical conicity, and longitudinal shortening) were evaluated using cardiac magnetic resonance images of 300 patients with myocardial infarction, and 1991 asymptomatic subjects, obtained from the Cardiac Atlas Project. (elsevier.com)
  • Accordingly, in the pre-reperfusion era, adverse ventricular remodeling-defined as a significant increase in left ventricular end-diastolic volume (relative increase greater than 25%) or a reduction in left ventricular ejection fraction (LVEF) (decreasing to below 45%)-was seen in more than one half of MI survivors. (thoracickey.com)
  • Patients underwent cardiac MRI at baseline and after cycle 17 of treatment for the determination of left ventricular volumes and LVEF. (oncologynurseadvisor.com)
  • Researchers evaluated cardiotoxicity as the change in indexed left ventricular end diastolic volume and LVEF. (oncologynurseadvisor.com)
  • and adverse LV remodeling (LVEF unchanged or worsened). (springermedizin.de)
  • Impaired LVEF, enhanced LV remodeling, inflammation, fibrosis, oxidative stress and apoptosis were reversed by reduction in mouse obesity. (biomedcentral.com)
  • Significant associations were observed between LV measures (LVEDV, LVESV, LVEF and LVM) and clinical outcomes at week 52 (all-cause death, CV death, HF hospitalisation and CV Death or HF hospitalisation), suggestive of a beneficial remodelling effect. (pace-cme.org)
  • In the present study, we sought to investigate whether the assessment of LV contractile performance during ESE testing may be useful to predict the risk of adverse LV remodeling in patients with HF and reduced or mildly reduced LVEF. (biomedcentral.com)
  • CE estimate of LVEF more accurately classified patients into LVEF less than 35%, 35% to 45%, and greater than 45% (agreement = 83%, kappa = 0.66 with CMR) compared with SPECT (agreement 61%, kappa = 0.36 with CMR).Conclusion: CE is more accurate than gated SPECT for the estimation of LV remodeling after AMI. (ucl.ac.uk)
  • The term ventricular remodeling refers to alteration in ventricular architecture, with associated increased volume and altered chamber configuration, driven on a histologic level by a combination of pathologic myocyte hypertrophy, myocyte apoptosis, myofibroblast proliferation, and interstitial fibrosis ( 1-3 ). (onlinejacc.org)
  • However, whether Ost can inhibit apoptosis and inflammation in right ventricle (RV) cardiomyocytes and prevent RV remodeling is not clear. (ovid.com)
  • To further investigate the roles of apoptosis and inflammation in the effects of Ost on MCT-induced RV remodeling, apoptosis-related factors and inflammatory-associated factors were examined by western blot. (ovid.com)
  • Overall, the present results indicate that Ost suppresses the RV remodeling process induced by MCT in rats, which may be at least partially mediated through the reduction of myocardial apoptosis and inflammation. (ovid.com)
  • Ad-miR-21 improves LV remodeling and decreases the apoptosis of myocardial cells, suggesting the possible mechanism by which Ad-miR-21 functions in protecting against I/R injury. (medsci.org)
  • It is thus not surprising that miRNAs are involved in the regulation of almost all the major cellular functions, such as apoptosis and necrosis, which are two key cellular events in cardiac remodeling after AMI. (medsci.org)
  • Mani, K & Kitsis, RN 2003, ' Myocyte apoptosis: Programming ventricular remodeling ', Journal of the American College of Cardiology , vol. 41, no. 5, pp. 761-764. (elsevier.com)
  • Apoptosis and post-infarction left ventricular remodeling. (units.it)
  • Ongoing apoptosis in the border zone and remote myocardium results in a reduction in cardiomyocyte number and might be therefore an important pathogenetic mechanism of ventricular remodeling after MI. (americorpshealth.biz)
  • Insulin Resistance Modifies the Effects of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial Infarction (from the OMEGA-REMODEL Randomized Clinical Trial). (harvard.edu)
  • Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Di. (nih.gov)
  • Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial. (nih.gov)
  • This study was performed to evaluate the effects of L-carnitine administration on long-term left ventricular dilation in patients with acute anterior myocardial infarction. (nih.gov)
  • A significant attenuation of left ventricular dilation in the first year after acute myocardial infarction was observed in patients treated with L-carnitine compared with those receiving placebo. (nih.gov)
  • L-Carnitine treatment initiated early after acute myocardial infarction and continued for 12 months can attenuate left ventricular dilation during the first year after an acute myocardial infarction, resulting in smaller left ventricular volumes at 3, 6 and 12 months after the emergent event. (nih.gov)
  • Left ventricular remodeling after acute myocardial infarction (AMI) is associated with adverse prognosis. (mdpi.com)
  • BACKGROUND AND OBJECTIVES: Angiotensin converting enzyme inhibitor (ACEI) is known to be effective in the prevention of left ventricular failure (LVF) after acute myocardial infarction. (koreamed.org)
  • Background The evaluation of ventricular remodelling and functional recovery is essential in predicting the prognosis of patients with acute myocardial infarction (AMI). (bmj.com)
  • Introduction: Left ventricular remodeling is a relatively prevalent complication of acute myocardial infarction (AMI), and it is associated with higher rates of medical issues and mortality. (civilica.com)
  • We examined the influence of several infarct characteristics, including MO, on LV remodeling in an optimally treated post-acute myocardial infarction cohort, using contrast-enhanced cardiac magnetic resonance. (druglib.com)
  • CONCLUSIONS: Late MO on predischarge contrast-enhanced cardiac magnetic resonance remains an ominous predictor of adverse LV remodeling despite powerful antiremodeling therapy and may be useful in the risk stratification of survivors of acute myocardial infarction. (druglib.com)
  • Our aim was to provide CMR criteria for assessing LV remodeling following acute MI. (springermedizin.de)
  • The MDCs for %ΔLVEDV and %ΔLVESV between the acute and follow-up CMR scans of 12% each may be used to define adverse or reverse LV remodeling post-STEMI. (springermedizin.de)
  • Inflammation as a driver of adverse left ventricular remodeling after acute myocardial infarction. (springermedizin.de)
  • It can not only accurately assess Left Ventricular (LV) volumes and function [ 5 ] but also detect and quantify the extent of both acute and chronic MI [ 6 , 7 ]. (alliedacademies.org)
  • Modification of neurohormonal acitivities, particularly the rennin-angiotensin-aldosterone system (RAAS), can significantly influence the process of ventricular remodeling after acute MI. (biomedcentral.com)
  • In recent years, tremendous progress has been made in the treatment of acute myocardial infarction (AMI), but pathological ventricular remodeling often causes survivors to suffer from fatal heart failure. (brad.ac.uk)
  • Nonetheless, the interpretation of adjustments in LVM following STEMI is complicated by the fact that on the acute scan, the presence of myocardial edema additionally contributes to the modifications in LVM acutely and due to this fact we did not investigate %Î"LVM in put up-STEMI LV remodeling. (rainesandwillow.com)
  • Despite the success of current therapies for acute myocardial infarction (MI), many patients still develop adverse cardiac remodeling and heart failure. (nature.com)
  • Restraining Infarct Expansion Preserves Left Ventricular Geometry and Function After Acute Anteroapical Infarction," Circulation 1999, 99: 135-142). (justia.com)
  • Background: Assessment of parameters of left ventricular (LV) remodeling after acute myocardial infarction (AMI) has both therapeutic and prognostic implication. (ucl.ac.uk)
  • In reperfused acute ST-segment elevation myocardial infarction (STEMI), infarct size and microvascular obstruction (MVO) are strong predictors of adverse LV remodeling and poor outcome. (biomedcentral.com)
  • Adverse ventricular remodeling after acute myocardial infarction (MI). (thoracickey.com)
  • After the insult occurs, a series of histopathological and structural changes occur in the left ventricular myocardium that lead to progressive decline in left ventricular performance. (wikipedia.org)
  • This review describes the structural organization of collagen within the myocardium, discusses its effect on ventricular function and considers whether therapy aimed at reducing fibrosis is efficacious in heart failure. (nih.gov)
  • The surgeon's purpose in remodeling the left ventricle is to relieve the excess demand placed on viable functional myocardium by akinetic infarcted myocardium. (oncologynurseadvisor.com)
  • To determine the role of microRNA 21(miR-21) on left ventricular remodeling of rat heart with ischemia-reperfusion (I/R) injury and to investigate the underlying mechanism of miR-21 mediated myocardium protection. (medsci.org)
  • Cardiac structural remodeling is associated with myocardium repair reactions, followed by scar formation in the infarcted area as well as changes in the noninfarcted myocardium, including interstitial fibrosis and collagen remodeling [ 3 ]. (medsci.org)
  • We also identified that mice with mild remodelling had significantly higher strains in the infarcted myocardium than those with severe injury. (visualsonics.com)
  • A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. (google.com)
  • In addition to ventricular enlargement, the relative proportions of the two muscle types in the salmonid ventricle (outer compact and inner spongy myocardium) can change during cardiac remodelling. (biologists.org)
  • Attempts to repair myocardial infarcts by transplanting cardiomyocytes or skeletal myoblasts have failed to reconstitute healthy myocardium and coronary vessels integrated structurally and functionally with the remaining viable portion of the ventricular wall. (pnas.org)
  • Attempts to replace the necrotic zone of the heart by transplanting cardiomyocytes or skeletal myoblasts ( 3 - 7 ), although successful in the survival of many of the grafted cells, have invariably failed to reconstitute healthy myocardium and coronary vessels integrated structurally and functionally with the spared ventricular wall. (pnas.org)
  • Our findings show functional recovery post-MI using rHCI by promoting a healing environment, cardiomyocyte survival, and less pathological remodeling of the myocardium. (nature.com)
  • The infarct expansion and ventricular remodeling are caused by these high stresses at the junction between the infarcted tissue and the normal myocardium. (justia.com)
  • In addition to immediate hemodynamic effects, the infarcted tissue and the myocardium or cardiac tissue undergo three major processes: Infarct Expansion, Infarct Extension, and Ventricular Remodeling. (justia.com)
  • Remodeling was defined as an at least 10% increase from baseline in the left ventricular end-diastolic volume. (mdpi.com)
  • Results showed that indexed left ventricular end diastolic volume increased in all 3 groups ( P =.36). (oncologynurseadvisor.com)
  • Patients with larger myocardial infarctions (MI), as reflected by higher serum creatine kinase (CK) levels, show greater 90-day increases in left ventricular end diastolic volume (LVEDV) than patients with smaller MI. (onlinejacc.org)
  • Left ventricular end-systolic and end-diastolic volumes are effective metrics for the severity of post-MI remodeling, and their changes are closely linked with clinical outcomes. (onlinejacc.org)
  • Our experiment demonstrates for the first time that the regression of left ventricular hypertrophy by pressure unloading not only leads to preserved diastolic function, and reversed maladaptive contractility augmentation, but also to maintained cardiac mechanoenergetics. (physiology.org)
  • In the group with pre-transplantation LVSD, the improvement in EF was accompanied by other significant changes consistent with reverse remodeling, including reduced LV end-diastolic dimension, reduced LV mass, reduced LV wall thickness, and reduced estimated right ventricular systolic pressure. (onlinejacc.org)
  • Left ventricular end-diastolic and end-systolic volumes were measured from apical four- and two-chamber views with the use of a modified Simpson's rule method. (onlinejacc.org)
  • After 12 months, heart rate was 8 beats/min lower in the carvedilol than in the placebo group, whereas left ventricular end-diastolic and end-systolic volumes were increased in the placebo group but reduced in the carvedilol group. (onlinejacc.org)
  • VR was defined as the increase ≥ 20% of the left ventricular end diastolic volume. (alliedacademies.org)
  • Adverse ventricular remodeling (VR) has been defined as an increased ≥ 20% of the Left Ventricular End Diastolic Volume (LVEDV) at 6 months after STEMI [8,9]. (alliedacademies.org)
  • PPM did not impair left ventricular mass regression or the recovery of diastolic function. (avhandlingar.se)
  • In contrast to previous reports in animal models, the PKC-α-lowering allele is associated with adverse left ventricular remodeling (higher mass, larger diastolic dimension), reduced fractional shortening, and higher risk of dilated cardiomyopathy in human populations. (eur.nl)
  • LV remodeling was defined as 20% increases in LV end-diastolic volume on the follow-up scan. (biomedcentral.com)
  • The definition of ventricular (or cardiac) remodeling refers to changes in size, shape, thickness, and elastance of the left and/or right ventricles involving both the infarcted and noninfarcted myocardial segments, and leading to impairment of regional or global systolic contractility and of diastolic function ( Table 36-1 ). (thoracickey.com)
  • Any known significant arrhythmia including atrial flutter, ventricular tachycardia, WPW-syndrome. (clinicaltrials.gov)
  • The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. (frontiersin.org)
  • The effect of modulation of the autonomic nervous system by RDN on atrial electrophysiology and ventricular rate control during atrial fibrillation (AF) is unknown. (ahajournals.org)
  • Subsequently, we investigated the effect of RDN on AF-induced shortening of atrial effective refractory period, AF inducibility, and ventricular rate control during AF maintained by rapid atrial pacing in 12 pigs undergoing RDN (n=7) or sham procedure (n=5). (ahajournals.org)
  • AF-induced atrial electrical remodeling, AF inducibility, and AF cycle length were not modified, but duration of AF episodes was shorter after RDN. (ahajournals.org)
  • A common scenario for remodeling is after myocardial infarction. (wikipedia.org)
  • The initial remodeling phase after a myocardial infarction results in repair of the necrotic area and myocardial scarring that may, to some extent, be considered beneficial since there is an improvement in or maintenance of LV function and cardiac output. (wikipedia.org)
  • New concepts in post-infarction ventricular remodeling. (biomedsearch.com)
  • Left ventricular remodeling (LVR) after myocardial infarction is associated with an increased risk of heart failure and death. (nih.gov)
  • It is becoming increasingly clear that circulating miRNAs could be promising biomarkers for various pathological processes in the heart, including myocardial infarction, myocardial remodeling and progression to heart failure. (mdpi.com)
  • Węgiel M, Rakowski T. Circulating biomarkers as predictors of left ventricular remodeling after myocardial infarction. (termedia.pl)
  • Aim: In the present paper we analyze data from the years 2005-2020 about circulating biomarkers of remodeling after myocardial infarction. (termedia.pl)
  • Ventricular remodeling, first described in animal models of left ventricular (LV) stress and injury, occurs progressively in untreated patients after large myocardial infarction and in those with dilated forms of cardiomyopathy. (onlinejacc.org)
  • Although originally described after myocardial infarction (MI), ventricular remodeling develops in response to a variety of forms of myocardial injury and increased wall stress ( 4,5 ). (onlinejacc.org)
  • The increase in left ventricular volume after a myocardial infarction is a component of the remodeling process. (eurekaselect.com)
  • Since the early 1980s, we have learned much about left ventricular (LV) morphologic change in patients after myocardial infarction (MI) and the relationship of such findings to subsequent clinical course ( 1-5 ). (onlinejacc.org)
  • Chronic sympathoexcitation is implicated in ventricular arrhythmogenesis (VAs) following myocardial infarction (MI), but the critical neural pathways involved are not well understood. (jci.org)
  • Here we show that Pn is critically involved in regulating the cardiac hypertrophic response, interstitial fibrosis, and ventricular remodeling following long-term pressure overload stimulation and myocardial infarction. (ahajournals.org)
  • Mice lacking the gene encoding Pn ( Postn ) were more prone to ventricular rupture in the first 10 days after a myocardial infarction, but surviving mice showed less fibrosis and better ventricular performance. (ahajournals.org)
  • A model of posterolateral myocardial infarction previously shown to produce chronic left ventricular (LV) remodeling and ischemic MR was performed in 28 sheep. (acc.org)
  • The assessment of post-myocardial infarction (MI) left ventricular (LV) remodeling by cardiovascular magnetic resonance (CMR) currently uses criteria defined by echocardiography. (springermedizin.de)
  • Objective: We hypothesised that, compared with culprit-only primary percutaneous coronary intervention (PCI), additional preventive PCI in selected patients with ST-elevation myocardial infarction with multivessel disease would not be associated with iatrogenic myocardial infarction, and would be associated with reductions in left ventricular (LV) volumes in the longer term. (gla.ac.uk)
  • CD45 signaling was closely associated with left ventricular remodeling after autoimmune myocarditis and myocardial infarction in mice. (nii.ac.jp)
  • The aim of this study was to investigate the relationship between myocardial infarction scar and ventricular Remodeling by Delayed-Enhancement Magnetic Resonance Imaging (DE-MRI). (alliedacademies.org)
  • Ventricular remodeling was defined as the structural changes in the left ventricular topography, occurring both acutely and chronically after infarction. (alliedacademies.org)
  • There are three major patterns, including concentric remodeling, eccentric hypertrophy and myocardial infarction [ 3 ]. (alliedacademies.org)
  • Our study was conducted to investigate the association between myocardial infarction scar detected by DE-MRI and ventricular remodeling. (alliedacademies.org)
  • Angiotensin-converting enzyme inhibitors and the angiotensin-receptor blocker valsartan ameliorate ventricular remodeling after myocardial infarction (MI). (biomedcentral.com)
  • Progressive enlargement of the heart chamber and deterioration of contractile function after myocardial infarction (MI), termed post-MI ventricular remodeling, is associated with development of heart failure and poor prognosis [ 1 - 3 ]. (biomedcentral.com)
  • 10 days) of AMI and in post-infarction left ventricular remodeling has not been characterized. (units.it)
  • This review briefly highlights the major mechanisms of left ventricular (LV) remodeling following myocardial infarction in heart failure and presents novel strategies to limit infarct size and retard the progression of LV remodeling. (elsevier.com)
  • Although adverse left ventricular shape changes (remodeling) after myocardial infarction (MI) are predictive of morbidity and mortality, current clinical assessment is limited to simple mass and volume measures, or dimension ratios such as length to width ratio. (biomedcentral.com)
  • We sought to determine the influence of granulocyte-macrophage colony-stimulating factor (GM-CSF) induction on post-myocardial infarction (MI) remodeling, especially in relation to the inflammatory response and myocardial fibrosis. (elsevier.com)
  • Within seconds of a myocardial infarction, the under-perfused myocardial cells no longer contract, leading to abnormal wall motion, high wall stresses within and surrounding the infarct, and depressed ventricular function. (justia.com)
  • Conclusions: The PLS orthogonal remodeling components had similar power to describe differences between myocardial infarction patients and asymptomatic subjects as principal component analysis, but were better associated with well-understood clinical indices of cardiac remodeling. (elsevier.com)
  • Conclusions Intracoronary deployment of BCM 2 to 5 days after successful reperfusion in subjects with large myocardial infarction did not reduce adverse LV remodeling or cardiac clinical events at 6 months. (sahmriresearch.org)
  • Krucoff, Mitchell W. / Bioabsorbable Intracoronary Matrix for Prevention of Ventricular Remodeling After Myocardial Infarction . (sahmriresearch.org)
  • We thus determined whether MCP-1 is increased in post-myocardial infarction (MI) hearts and its blockade can attenuate the development of left ventricular (LV) remodeling and failure. (elsevier.com)
  • Pressure unloading represents the only effective therapy in increased afterload-induced left ventricular hypertrophy (LVH) as it leads to myocardial reverse remodeling (reduction of increased left ventricular mass, attenuated myocardial fibrosis) and preserved cardiac function. (physiology.org)
  • Pn −/− mice also showed less fibrosis and hypertrophy following long-term pressure overload, suggesting an intimate relationship between Pn and the regulation of cardiac remodeling. (ahajournals.org)
  • 4,5 For example, dilated cardiomyopathy is characterized by a thinning of the ventricular walls that likely results, in part, from a "loosening" of the ECM within the heart, whereas a restrictive cardiomyopathy is often associated with an increase in ventricular stiffness, an overabundance of fibrosis, and inappropriate ECM expansion. (ahajournals.org)
  • As assessed using three-dimensional (3D) magnetic resonance imaging (MRI), what changes in left ventricular (LV) end-systolic dimension and volume occur among patients with isolated degenerative mitral regurgitation (MR)? (acc.org)
  • We aimed to examine longitudinal changes in left ventricular (LV) structure and function and evaluate factors associated with LV remodelling in children on chronic haemodialysis. (springermedizin.de)
  • We hypothesized that weight loss and gain in the Multi-Ethnic Study of Atherosclerosis (MESA) would coincide with changes in left ventricular (LV) mass -- key features in the progression to obesity-related HF. (biomedcentral.com)
  • In this review, passive ventricular remodeling is described in Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM), Ischemic Cardiomyopathy (ICM), and Arrhythmogenic Cardiomyopathy (ACM), with a main focus on the heterogeneity of those alterations mentioned above. (frontiersin.org)
  • The ventricular remodeling operation (also known as the Batista procedure, partial left ventriculectomy, heart reduction surgery, and wedge resection of the heart) has been proposed as a surgical procedure to replace or postpone heart transplantation in patients with dilated non-ischemic cardiomyopathy. (aetna.com)
  • BACKGROUND: Different influences of left ventricular (LV) remodeling on anterior and posterior mitral leaflet (AML and PML) tethering in ischemic mitral regurgitation (MR) has not been fully investigated. (biomedsearch.com)
  • The anesthetic management of patients with ischemic congestive heart failure who present for LV aneurysm resection and remodeling is among the most challenging for the cardiac anesthesiologist. (oncologynurseadvisor.com)
  • Cardiac transplantation is usually preferred over ventricular remodeling for patients with end-stage ischemic cardiomyopathy whose GEF is less than 20%, CEF less than 30%, cardiac output less than 1.5 L/min, and mean pulmonary artery pressure greater than 25 mm Hg. (oncologynurseadvisor.com)
  • The aim of this study was to investigate the efficacy of an ACEI, Cilazapril, on left ventricular remodeling in patients with ischemic LVF, who underwent coronary interventions. (koreamed.org)
  • CONCLUSION: Cilazapril is a beneficial adjunctive therapeutic agent in patients with ischemic left ventricular failure for the prevention of ventricular dilatation, especially after coronary intervention. (koreamed.org)
  • Primary cultures of neonatal rat cardiac ventricular myocytes were performed and cell ischemic injury was induced by hypoxia in a serum- and glucose-free medium, and reoxygenation (H/R).MiR-21 inhibitor and pre-miR-21 were respectively added to the culture medium for the miR-21 knockdown and for the miR-21 up-regulation. (medsci.org)
  • The aim of this study, a substudy of the Australia-New Zealand trial of carvedilol in patients with heart failure due to ischemic heart disease, was to determine the effects of this treatment on left ventricular size and function with the use of quantitative two-dimensional (2D) echocardiography. (onlinejacc.org)
  • Combined annular and subvalvular repair (severing secondary mitral chordae) improved long-term reduction of chronic ischemic MR and LV reverse remodeling in this sheep model, without decreasing global or segmental LV function at follow-up. (acc.org)
  • We examined the effects of surgery of ischemic mitral valve on reverse remodeling of left ventricle, impact on functional state of patients after operation, assessment of early morbidity and mortality. (biomedcentral.com)
  • In patients with ischemic mitral valve better results of left ventricular reverse remodeling were obtained with combined CABG and mitral valve surgery than in patients without surgical correction of ischemic mitral valve. (biomedcentral.com)
  • This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling). (wikipedia.org)
  • Physiological remodeling is reversible while pathological remodeling is mostly irreversible. (wikipedia.org)
  • The term "reverse remodeling" in cardiology implies an improvement in ventricular mechanics and function following a remote injury or pathological process. (wikipedia.org)
  • The cardiac extracellular matrix is a dynamic structural support network that is both influenced by, and a regulator of, pathological remodeling and hypertrophic growth. (ahajournals.org)
  • 0.001] and significantly correlated to left ventricular longitudinal and transverse diameters [r=+0.70 (P= 0.016) and r=+0.63 (P=0.004) respectively]. (units.it)
  • Left ventricular motion patterns and myocardial velocities were recorded for radial, circumferential and longitudinal motion. (ox.ac.uk)
  • Radial, circumferential and longitudinal velocity curves were obtained separately for 16 ventricular segments. (ox.ac.uk)
  • Ventricular torsion rate and longitudinal strain rate were also derived pre-and post-surgery. (ox.ac.uk)
  • Despite improved ventricular contractility during systole, peak longitudinal and rotational velocities decreased or showed no significant changes. (ox.ac.uk)
  • Conclusion: Our results suggest that post-operative changes after CABG are limiting ventricular rotational and longitudinal motions, despite an increase in ventricular contractility due to revascularization. (ox.ac.uk)
  • To investigate the association of longitudinal changes in weight on ventricular remodeling, we investigated 2,351 patients in MESA who underwent two serial cardiac magnetic resonance imaging (CMR) examinations at initial enrollment (2002) and at follow-up (2011) with available obesity status. (biomedcentral.com)
  • Therefore, in clinical practice, ventricular structure and function are commonly assessed using echocardiography. (hindawi.com)
  • The most common method of remodeling assessment was echocardiography and the most frequent time point for remodeling evaluation was 6 months. (termedia.pl)
  • To investigate these possibilities, we evaluated in a cross-sectional population of 1223 healthy men, aged 46 (6) years, associations between endogenous testosterone, oestradiol and left ventricular structure and function (echocardiography). (ugent.be)
  • Contrast echocardiography (CE) has the advantage of simultaneously assessing myocardial perfusion and LV remodeling. (ucl.ac.uk)
  • ACE I/D and β 1AR Arg389Gly polymorphisms are independent predictors of reverse remodeling and systolic function recovery in CHF patients under optimal treatment. (hindawi.com)
  • The purpose of this study is to assess long-term outcomes of CRT on left ventricular reverse remodelling and functional recovery in patients with advanced heart failure and to establish predictors for positive response to cardiac resynchronization therapy. (omicsonline.org)
  • Conclusion: E/E´ ratio ≥ 12 and LAD as the culprit artery are important predictors for adverse ventricular remodeling and should be considered for early medical treatment. (alliedacademies.org)
  • Larger infarct size, greater extent of initial wall motion abnormalities, and greater initial reduction in global systolic function are all independent predictors of adverse ventricular remodeling ( Table 36-2 ). (thoracickey.com)
  • After a large MI, LV remodeling is associated with progressive dilation, initially through infarct zone expansion ( 1 ). (onlinejacc.org)
  • Ventricular dilation, indeed, begets further dilation. (thoracickey.com)
  • Advances in the epidemiology of heart failure and left ventricular remodeling. (springermedizin.de)
  • We hypothesized that clusters of plasma microRNAs (miRNAs) associated with left ventricular (LV) remodeling in human HF would identify novel subsets of genes involved in HF in animal models. (ovid.com)
  • Serenella Castelvecchio, Lorenzo Menicanti and Marisa Di Donato, " Surgical Ventricular Restoration to Reverse Left Ventricular Remodeling", Current Cardiology Reviews (2010) 6: 15. (eurekaselect.com)
  • prognosis is determined by remaining left ventricular function and the importance of systolic function has been well established. (alliedacademies.org)
  • The surviving cardiac myocytes either arrange in parallel or in series to each other, contributing to ventricular dilatation or ventricular hypertrophy, depending on the loading stress on the ventricular wall. (wikipedia.org)
  • The investigators will evaluate ventricular reversed remodelling after double lung transplantation (LTX) in patients with pulmonary arterial hypertension (PAH), measured with cardiac magnetic resonance imaging (MRI). (clinicaltrials.gov)
  • Reversed remodelling will be compared with control patients without PAH (e.g. (clinicaltrials.gov)
  • The purpose of this study is to evaluate the safety and efficacy of ALT-711 in the treatment of isolated systolic hypertension in a formal study in patients with left ventricular hypertrophy. (clinicaltrials.gov)
  • In our patients (n = 36) exercise capacity and right ventricular volume index improved similarly 6 months after PPVI in patients with and without important TR. (unboundmedicine.com)
  • Recent studies have reported that obstructive sleep apnea (OSA) patients present alterations in right ventricular (RV) structure and function. (hindawi.com)
  • Results showed that levels of plasma miR-208b and miR-34a were significantly higher in patients with remodeling than those without. (mdpi.com)
  • The authors find that patients with concentric hypertrophy (increased left ventricular mass index [LVMi] and relative wall thickness [RWT]) are at greatest risk for the combined end point of CV death, recurrent MI, HF, stroke, or resuscitation after cardiac arrest, as well as for each individual component. (onlinejacc.org)
  • Those patients with eccentric hypertrophy (increased LVMi and normal RWT) and concentric remodeling (normal LVMi and increased RWT) had lesser increases in risk. (onlinejacc.org)
  • Patients with a greater degree of remodeling manifest worse outcomes, with increased rates of death and the development of HF ( 3,4 ). (onlinejacc.org)
  • Moreover, MRI of LV end-systolic volume from summated serial short-axis slices was significantly greater than LV end-systolic volume assessed with the Bullet formula in MR patients, a finding attributed to more spherical remodeling distal to the tips of the papillary muscles (p (acc.org)
  • Despite apparently preserved LV end-systolic dimension, patients with MR demonstrate significant spherical mid- to apical-LV end-systolic remodeling that contributes to higher LV end-systolic volume than predicted by calculations based on standard geometry. (acc.org)
  • The aim of this study was to determine the E/E' ratio, to predict the adverse ventricular remodeling (VR) in patients presenting with STEMI. (alliedacademies.org)
  • Objective To determine the plasma catestatin level in patients with AMI, and investigate the association between plasma catestatin and heart function, and with left ventricular remodelling (LVR). (bmj.com)
  • The main objective of this study was to evaluate whether GLS could adequately predict LV remodeling in AMI patients. (civilica.com)
  • All studies involving patients with their first reported case of AMI were examined for GLS by 2D-STE and were evaluated for LV remodeling at a three-month follow-up point. (civilica.com)
  • METHODS AND RESULTS: We analyzed the cis expression quantitative trait locus for PRKCA marked by rs9912468 using 313 left ventricular specimens from European Ancestry patients. (eur.nl)
  • Pulmonary valve replacement leads to a favourable early reverse remodelling with a reduction in RV volumes and improved function in all patients regardless of their preoperative indexed right ventricular volume. (springer.com)
  • Statins possess pharmacologic properties (independent of cholesterol lowering) that may be beneficial on ventricular remodeling in such patients. (monash.edu)
  • This study thus aimed to assess RVSD and remodelling in a cohort of PPCM patients in Kano, Nigeria. (biomedcentral.com)
  • We hypothesised that many PPCM patients would also experience RV reverse remodelling over time. (biomedcentral.com)
  • This is important since interventions that have been shown to improve mortality in patients with heart failure such as angiotensin converting enzyme inhibitor and β-blockers had a favorable impact on the LV remodeling process. (elsevier.com)
  • Reverse remodeling of left ventricle occurred more frequently in group of patients with combined surgery, 71.8% vs 41.5% in only CABG group. (biomedcentral.com)
  • This mode provided a continuous scale where remodeling can be quantified and visualized, showing that MI patients tend to present larger size and more spherical shape, more bulging of the apex, and thinner wall thickness. (biomedcentral.com)
  • This combination of clinical and basic science studies into the impact of diabetes on LV remodeling will enable us to identify novel treatment strategies designed to close the gap in outcomes between diabetic and non-diabetic patients with heart disease. (grantome.com)
  • On average, 10% of post-MI patients develop adverse ventricular remodeling that will ultimately lead to advanced heart failure 1 , which has a 5-year mortality of ~50% 4 . (nature.com)
  • These data show that in this population of patients with advanced HF, intramyocardial administration of cardiopoietic stem cells induced significant reverse left ventricular remodelling after 52 weeks. (pace-cme.org)
  • Effects on remodelling appear most pronounced in patients who received a moderate number of injections. (pace-cme.org)
  • Objective: The purpose of this study was to obtain new details of three-dimensional left ventricular wall motion related to ventricular remodeling in patients undergoing coronary artery bypass graft (CABG) surgery. (ox.ac.uk)
  • Adverse LV remodeling was detected in 34 (22%) patients. (biomedcentral.com)
  • In patients with HF and reduced or mildly reduced EF, a compromised ESE-derived peak ESPVR, that reflects impaired LV contractility, resulted to be the most powerful predictor of adverse LV remodeling. (biomedcentral.com)
  • Purpose: To prospectively compare contrast material-enhanced (CE) magnetic resonance (MR) imaging-derived right-to-left ventricle pulmonary transit time (PTT), left ventricular (LV) full width at half maximum (FWHM), and LV time to peak (TTP) between patients with pulmonary arterial hypertension (PAH) and healthy volunteers and to correlate these measurements with survival markers in patients with PAH. (elsevier.com)
  • We aimed to evaluate the accuracy of CE to assess LV remodeling after AMI compared with technetium-99m sestamibi gated single photon emission computed tomography (SPECT).Methods: Accordingly, 36 consecutive patients underwent gated SPECT, CE, and cardiovascular magnetic resonance imaging (CMR) 7 to 10 days after AMI. (ucl.ac.uk)
  • To examine different influences of LV remodeling on AML and PML tethering, interaction between AML/PML and LV sphericity was tested using multiple regression analysis. (biomedsearch.com)
  • It is clear from this review that the understanding of the mechanisms responsible for the regression of ventricular remodeling is still unclear. (elsevier.com)
  • Logistic regression was employed to determine the association between the remodeling index and MI. (biomedcentral.com)
  • Finally, regression models suggested linear decreases in left ventricular mass regression with increasing weight loss, suggesting no threshold effect for weight loss on cardiac remodeling. (biomedcentral.com)
  • Partial least squares (PLS) regression of left ventricular shape models resulted in remodeling components that were optimally associated with each remodeling index. (elsevier.com)
  • A one-factor PLS regression led to more decoupling between scores from the different remodeling components across the entire cohort, and zero correlation between clinical indices and subsequent scores. (elsevier.com)
  • The results will lay a strong foundation to understand the mechanisms of left ventricular remodelling post-MI. (biomedcentral.com)
  • This article examines the relationship between LV remodeling and clinical outcomes of heart failure syndrome from several different perspectives. (biomedsearch.com)
  • Background- The clinical significance and long-term consequences of left ventricular (LV) hypertrophy associated with intensive athletic conditioning remain unresolved. (ahajournals.org)
  • The authors concluded that PLV could provide structural remodeling of the heart that might result in temporary improvement in clinical compensation. (aetna.com)
  • In an overview on the surgical management of heart failure, Zeltsman and Acker (2002) stated that direct surgical approaches to restoring normal geometry and size to failing hearts, such as left ventricular reduction (Batista procedure) are under clinical investigation. (aetna.com)
  • Roubicek T, Stros J, Kucera P, Nedbal P, Cerny J, Polasek R, Wichterle D. Combination of left ventricular reverse remodeling and brain natriuretic peptide level at one year after cardiac resynchronization therapy predicts long-term clinical outcome. (umassmed.edu)
  • Beyond the impact of abnormal cardiac structure on cardiovascular events, the relationship between LV remodeling and clinical outcomes is likely linked through common local and systemic factors driving vascular as well as myocardial pathology. (onlinejacc.org)
  • These findings substantiate the importance of ventricular remodeling as central in the pathophysiology of advancing heart failure and support the role of measures of LV remodeling in the clinical investigation of novel heart failure treatments. (onlinejacc.org)
  • P=0.01) that provided risk discrimination for LV reverse remodeling superior to a clinical model (C statistic, 0.58 for a clinical model versus 0.71 for RNA-based model). (ovid.com)
  • More importantly, it bridges a gap between the hypertension and HF research arenas and provides clues to the mechanisms through which LV remodeling is linked to adverse clinical outcomes. (onlinejacc.org)
  • Left ventricular (LV) remodeling in Chagas heart disease (CHD) depends on the severity of the initial insult and may have clinical implication. (ahajournals.org)
  • Valsartan in post-MI remodeling (VALID) is a randomized, open-label, single-blinded multicenter study designed to compare the efficacy of different clinical dose of valsartan on the post-MI ventricular remodeling. (biomedcentral.com)
  • However, traditional clinical indices currently used to quantify remodeling are limited to simple measures of mass and volume, or ventricular dimension ratios, discarding much of the available shape information. (biomedcentral.com)
  • After adjustment for hypertension, diabetes, age, race, and other clinical risk factors, every 10% decrease in weight was associated with a fully covariate-adjusted 3% additional decrease in height-indexed left ventricular mass. (biomedcentral.com)
  • Geometric remodeling indices have been shown to have prognostic value in predicting adverse events in the clinical literature, but these often describe interrelated shape changes. (elsevier.com)
  • We developed a novel method for deriving orthogonal remodeling components directly from any (moderately independent) set of clinical remodeling indices. (elsevier.com)
  • Quantitative evaluation of ventricular remodeling can therefore be used to predict clinical outcome and the therapeutic effects of a drug or device intervention. (thoracickey.com)
  • We analyze inclusion criteria for individual studies, time points of serum collection and remodeling assessment as well as imaging methods. (termedia.pl)
  • Of the CMR methods, Delayed-Enhancement Magnetic Resonance Imaging (DE-MRI) has been considered as the best imaging method for ventricular remodeling. (alliedacademies.org)
  • METHODS: We aimed to establish whether or not, in addition to these changes, there is also an element of concentric remodeling in obesity that was predicted by ascending aortic stiffness. (ox.ac.uk)
  • IMCA was compared to linear discriminant analysis (LDA), both supervised methods, to extract the most discriminatory global shape changes associated with remodeling after MI. (biomedcentral.com)
  • Conclusions- LV remodeling was evident after long-term detraining, with significant reduction in cavity size and normalization of wall thickness. (ahajournals.org)
  • Long-term athletic training is associated with cardiac morphological changes, including increased left ventricular (LV) cavity dimension, wall thickness, and mass, described as athlete's heart. (ahajournals.org)
  • After 2 weeks, rats were killed for assessment of right ventricular hypertrophy (RVH), wall thickness of small pulmonary arteries, vessels density, radial alveolar counts and mean linear intercepts. (nih.gov)
  • He noted that although PLV is able to reduce left ventricular volume and probably decreases ventricular wall stress, reduction of volume and stress is insufficient to improve ventricular function. (aetna.com)
  • Although long-term results after LV remodeling surgery appear to be satisfactory, outcome appears to be better if the surgical technique results in a more conical LV shape, as opposed to volume reduction alone. (oncologynurseadvisor.com)
  • We defined LV reverse remodeling as a 15% reduction in LV end-systolic volume index. (ovid.com)
  • Here we report a reduction of ventricular heart rate in a patient with permanent AF undergoing RDN. (ahajournals.org)
  • The lack of reduction of left ventricular end-systolic index and/or death from heart failure was considered as non-response to CRT. (omicsonline.org)
  • Objective To explore the genetic landscape of a well selected dilated cardiomyopathy (DCM) cohort, assessing the possible relation between different genotypes and left ventricular reverse remodelling (LVRR). (bmj.com)
  • Therefore, using nanoparticles as delivery vehicles of small molecules, polypeptides, etc to improve post-infarct ventricular remodeling are expected. (brad.ac.uk)
  • Dong C, Ma A and Shang L (2018) Nanoparticles for post-infarct ventricular remodeling. (brad.ac.uk)
  • Adverse ventricular remodeling after STEMI has been associated with an increased up to 3 times the risk of overall mortality in 5 years and in the presence of symptoms even up to 10 times [ 10 ]. (alliedacademies.org)
  • The chronic consequences of MI leading to global structural and functional changes to the heart are summarized in a process known as adverse ventricular remodeling . (thoracickey.com)
  • In the previous study, active extract of Radix Scrophularia (ACRS) demonstrated beneficial effects on ventricular remodeling induced by coronary artery ligation and lowered blood pressure in rats. (springeropen.com)
  • 2011 ). In the previous study, we revealed that active extract of Radix Scrophularia (ACRS) exhibited beneficial effects on ventricular remodeling in rats induced by coronary artery ligation (Huang et al. (springeropen.com)
  • Surgical Ventricular Restoration (SVR) has been introduced as an optional therapeutic strategy to reduce left ventricular volume and restore heart geometry. (eurekaselect.com)
  • 1-3 One common characteristic that underlies nearly all forms of heart failure is a remodeling of the extracellular matrix (ECM) and an associated change in ventricular geometry. (ahajournals.org)
  • Left ventricular mass (LVM) in g/m 2.7 , geometry and LV function were compared at baseline (dialysis start) with follow-up studies at least 6 months following commencement. (springermedizin.de)
  • We sought to determine the impact of visceral fat and subcutaneous fat (SQ) depots on left ventricular (LV) structure, function, and geometry in the Multi-Ethnic Study of Atherosclerosis (MESA). (qmul.ac.uk)
  • Ventricular geometry can also change, for example salmonids respond to a culture environment with a more rounded (see Gamperl and Farrell, 2004 ) and smaller ventricle ( Graham and Farrell, 1989 ) compared with their wild counterparts. (biologists.org)
  • Elevations in myocardial stress initiate structural remodeling of the heart in an attempt to normalize the imposed stress. (nih.gov)
  • It remains unclear how underlying transmural structural remodeling corresponds to LV wall systolic deformation as hypertensive hypertrophy progresses. (ahajournals.org)
  • The structural pattern of LV remodeling and evidence of scarring on cardiac magnetic resonance have additional prognostic value. (onlinejacc.org)
  • Decreased LV strain after surgery suggests that a volumetric analysis of LV remodeling and function may be preferred to evaluate disease progression in isolated MR. (acc.org)
  • IMCA enables better characterization of global remodeling than LDA, and can be used to quantify progression of disease and the effect of treatment. (biomedcentral.com)
  • Moreover, caspase inhibition can reduce the occurrence of heart failure or impede its progression following MI by attenuating ventricular remodeling and protecting against myocardial protein cleavage [152-154]. (americorpshealth.biz)
  • Since M1 and M2 macrophages are responsible for extracellular matrix (ECM) destruction and construction, respectively, the transition and dynamic balance between two macrophage phenotypes might lead to the balance between ECM destruction and construction, and thus determine the ECM remodeling post-MI. (biomedcentral.com)
  • The preoperative mean indexed right ventricular stroke volume was reduced from 72 ± 20 ml/m 2 to 50 ± 6 ml/m 2 postoperatively, p = 0.002. (springer.com)
  • 01), right ventricular stroke volume index (P ≤ .01), and pulmonary artery capacitance (P ≤ .02). (elsevier.com)
  • These myocardial infarctions result in an immediate depression in ventricular function and all of these infarctions are very likely to expand, provoking a cascading sequence of myocellular events known as ventricular remodeling. (justia.com)
  • Background Bioabsorbable cardiac matrix (BCM) is a novel device that attenuates adverse left ventricular (LV) remodeling after large myocardial infarctions in experimental models. (sahmriresearch.org)
  • CONCLUSIONS: LV remodeling augments tethering of both AML and PML, with greater influence on PML. (biomedsearch.com)
  • Conclusions - The activation of MCP-1 expression contributes to the LV remodeling and failure after MI. (elsevier.com)
  • Aetna considers surgical ventricular restoration, also known as the Dor procedure, experimental and investigational because its effectiveness has not been established. (aetna.com)
  • Since that time, multiple studies have substantiated the relationship between infarct size and the extent of left ventricular (LV) remodeling ( 3,7,8 ). (onlinejacc.org)
  • Changes in hemodynamic parameters were recorded at 1 week after I/R. Histological diagnosis was achieved by hematoxylin and eosin (H&E). Left ventricular (LV) dimensions, myocardial infarct size, LV/BW, collagen type Ⅰ, type Ⅲ and PCNA positive cells were measured. (medsci.org)