A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
A condition in which HEART VENTRICLES exhibit impaired function.
A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Contractile activity of the MYOCARDIUM.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
The hollow, muscular organ that maintains the circulation of the blood.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Elements of limited time intervals, contributing to particular results or situations.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This abnormality is associated with high levels of CATECHOLAMINES, either administered or endogenously secreted from a tumor or during extreme stress.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.
An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.
The hemodynamic and electrophysiological action of the right HEART VENTRICLE.
The circulation of blood through the CORONARY VESSELS of the HEART.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.
A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The hemodynamic and electrophysiological action of the LEFT ATRIUM.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The span of viability of a tissue or an organ.
Examinations used to diagnose and treat heart conditions.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
The chambers of the heart, to which the BLOOD returns from the circulation.
Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Drugs used to cause dilation of the blood vessels.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
The valve between the left atrium and left ventricle of the heart.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
Insurance coverage of a physical or mental health condition, disability, or illness existing before health insurance is applied for or enrolled in.
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).
The pressure within the CARDIAC ATRIUM. It can be measured directly by using a pressure catheter (see HEART CATHETERIZATION). It can be also estimated using various imaging techniques or other pressure readings such as PULMONARY CAPILLARY WEDGE PRESSURE (an estimate of left atrial pressure) and CENTRAL VENOUS PRESSURE (an estimate of right atrial pressure).
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
A condition characterized by the thickening of ENDOCARDIUM due to proliferation of fibrous and elastic tissue, usually in the left ventricle leading to impaired cardiac function (CARDIOMYOPATHY, RESTRICTIVE). It is most commonly seen in young children and rarely in adults. It is often associated with congenital heart anomalies (HEART DEFECTS CONGENITAL;) INFECTION; or gene mutation. Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
The veins and arteries of the HEART.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The hemodynamic and electrophysiological action of the HEART VENTRICLES.
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
Counterpulsation in which a pumping unit synchronized with the patient's electrocardiogram rapidly fills a balloon in the aorta with helium or carbon dioxide in early diastole and evacuates the balloon at the onset of systole. As the balloon inflates, it raises aortic diastolic pressure, and as it deflates, it lowers aortic systolic pressure. The result is a decrease in left ventricular work and increased myocardial and peripheral perfusion.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Surgery performed on the heart.
Disease having a short and relatively severe course.
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Physiological disturbances in normal sexual performance in either the male or the female.
The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).
Surgical insertion of synthetic material to repair injured or diseased heart valves.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
The period following a surgical operation.
A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
The blood pressure in the ARTERIES. It is commonly measured with a SPHYGMOMANOMETER on the upper arm which represents the arterial pressure in the BRACHIAL ARTERY.
The measurement of visualization by radiation of any organ after a radionuclide has been injected into its blood supply. It is used to diagnose heart, liver, lung, and other diseases and to measure the function of those organs, except renography, for which RADIOISOTOPE RENOGRAPHY is available.
A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.
AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
The innermost layer of the heart, comprised of endothelial cells.
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
The condition of an anatomical structure's being dilated beyond normal dimensions.
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
Diseases that do not exhibit symptoms.
The transference of a heart from one human or animal to another.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.
Agents that promote the excretion of urine through their effects on kidney function.
Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.
Drugs that bind to and block the activation of MINERALOCORTICOID RECEPTORS by MINERALOCORTICOIDS such as ALDOSTERONE.
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
This structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Shock resulting from diminution of cardiac output in heart disease.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures.
A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE.
A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).
A phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist.
Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.
Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Methods to induce and measure electrical activities at specific sites in the heart to diagnose and treat problems with the heart's electrical system.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The confinement of a patient in a hospital.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Peptides that regulate the WATER-ELECTROLYTE BALANCE in the body, also known as natriuretic peptide hormones. Several have been sequenced (ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; C-TYPE NATRIURETIC PEPTIDE).
An electrical current applied to the HEART to terminate a disturbance of its rhythm, ARRHYTHMIAS, CARDIAC. (Stedman, 25th ed)

Effect of coronary occlusion on left ventricular function with and without collateral supply during beating heart coronary artery surgery. (1/4972)

OBJECTIVE: To study the effects of coronary occlusion and collateral supply on left ventricular (LV) function during beating heart coronary artery surgery. DESIGN: Prospective intraoperative study, performed at baseline, during wall stabilisation, coronary artery occlusion, and 2 and 10 minutes after reperfusion. Transoesophageal M mode echocardiograms, simultaneous high fidelity LV pressure, and thermodilution cardiac output were measured. LV anterior wall thickening, thinning velocities, thickening fraction, regional work, and power production were derived. Asynchrony during the isovolumic periods was quantified as cycle efficiency. SETTING: Tertiary referral cardiac centre. PATIENTS: 14 patients with stable angina, mean (SD) age 62 (7) years, undergoing left anterior descending artery grafting using the "Octopus" device. RESULTS: Collaterals were absent in nine patients and present in five. Epicardial stabilisation did not affect LV function. Results are expressed as mean (SD). Coronary occlusion (15.6 (2) minutes) depressed anterior wall thickening (1.4 (0.6) v 2.6 (0.6) cm/s) and thinning velocities (1.4 (0.5) v 3.0 (0.6) cm/s), regional work (2.2 (0.8) v 4.6 (0.6) mJ/cm2), and power (21 (4) v 33 (5) mW/cm2) in patients without collaterals (p < 0.05 for all), but only wall thinning (3.5 (0.5) v 4.8 (0.5) cm/s, p < 0.05) in patients with collaterals. All returned to baseline within 10 minutes of reperfusion. Cycle efficiency and regional work were impaired at baseline and fell during occlusion, regardless of collaterals. Within 10 minutes of reperfusion both had increased above baseline. CONCLUSIONS: Coronary occlusion for up to 15 minutes during beating heart coronary artery surgery depressed standard measurements of systolic and diastolic anterior wall function in patients without collaterals, but only those of diastolic function in patients with collaterals. Regional synchrony decreased in both groups. All disturbances regressed within 10 minutes of reperfusion.  (+info)

QT dispersion in patients with chronic heart failure: beta blockers are associated with a reduction in QT dispersion. (2/4972)

OBJECTIVE: To compare QT dispersion in patients with impaired left ventricular systolic function and in matched control patients with normal left ventricular systolic function. DESIGN: A retrospective, case-control study with controls matched 4:1 for age, sex, previous myocardial infarction, and diuretic and beta blocker treatment. SETTING: A regional cardiology centre and a university teaching hospital. PATIENTS: 25 patients with impaired left ventricular systolic function and 100 patients with normal left ventricular systolic function. MAIN OUTCOME MEASURES: QT and QTc dispersion measured by three methods: the difference between maximum and minimum QT and QTc intervals, the standard deviation of QT and QTc intervals, and the "lead adjusted" QT and QTc dispersion. RESULTS: All measures of QT/QTc dispersion were closely interrelated (r values 0.86 to 0.99; all p < 0.001). All measures of QT and QTc dispersion were significantly increased in the patients with impaired left ventricular systolic function v controls (p < 0.001): 71.9 (6.5) (mean (SEM)) v 46.9 (1.7) ms for QT dispersion, and 83.6 (7.6) v 54.3 (2.1) ms(-1-2) for QTc dispersion. All six dispersion parameters were reduced in patients taking beta blockers (p < 0.05), regardless of whether left ventricular function was normal or impaired-by 9.4 (4.6) ms for QT dispersion (p < 0.05) and by 13.8 (6. 5) ms(-1-2) for QTc dispersion (p = 0.01). CONCLUSIONS: QT and QTc dispersion are increased in patients with systolic heart failure in comparison with matched controls, regardless of the method of measurement and independently of possible confounding factors. beta Blockers are associated with a reduction in both QT and QTc dispersion, raising the possibility that a reduction in dispersion of ventricular repolarisation may be an important antiarrhythmic mechanism of beta blockade.  (+info)

Enteroviral RNA replication in the myocardium of patients with left ventricular dysfunction and clinically suspected myocarditis. (3/4972)

BACKGROUND: Previous studies dealing with the detection of enteroviral RNA in human endomyocardial biopsies have not differentiated between latent persistence of the enteroviral genome and active viral replication. Enteroviruses that are considered important factors for the development of myocarditis have a single-strand RNA genome of positive polarity that is transcribed by a virus-encoded RNA polymerase into a minus-strand mRNA during active viral replication. The synthesis of multiple copies of minus-strand enteroviral RNA therefore occurs only at sites of active viral replication but not in tissues with mere persistence of the viral genome. METHODS AND RESULTS: We investigated enteroviral RNA replication versus enteroviral RNA persistence in endomyocardial biopsies of 45 patients with left ventricular dysfunction and clinically suspected myocarditis. Using reverse-transcriptase polymerase chain reaction in conjunction with Southern blot hybridization, we established a highly sensitive assay to specifically detect plus-strand versus minus-strand enteroviral RNA in the biopsies. Plus-strand enteroviral RNA was detected in endomyocardial biopsies of 18 (40%) of 45 patients, whereas minus-strand RNA as an indication of active enteroviral RNA replication was detected in only 10 (56%) of these 18 plus-strand-positive patients. Enteroviral RNA was not found in biopsies of the control group (n=26). CONCLUSIONS: These data demonstrate that a significant fraction of patients with left ventricular dysfunction and clinically suspected myocarditis had active enteroviral RNA replication in their myocardium (22%). Differentiation between patients with active viral replication and latent viral persistence should be particularly important in future studies evaluating different therapeutic strategies. In addition, molecular genetic detection of enteroviral genome and differentiation between replicating versus persistent viruses is possible in a single endomyocardial biopsy.  (+info)

Endogenous endothelin-1 depresses left ventricular systolic and diastolic performance in congestive heart failure. (4/4972)

Endothelin-1 (ET-1) is a positive inotrope in normal hearts; however, the direct cardiac effects of endogenous ET-1 in congestive heart failure (CHF) are unknown. We evaluated the cardiac responses to endogenous ET-1 using an ETA and ETB receptor blocker (L-754,142) in seven conscious dogs before and after pacing-induced CHF. Before CHF, when the plasma ET-1 was 7.3 +/- 1.7 fmol/ml, L-754,142 caused no significant alterations in heart rate, left ventricular (LV) end-systolic pressure, total systemic resistance, and the time constant of LV relaxation (tau). LV contractile performance, measured by the slopes of LV pressure (P)-volume (V) relation (EES), dP/dtmax-end-diastolic V relation (dE/dtmax), and stroke work-end-diastolic V relation, was also unaffected. After CHF, when the plasma ET-1 was significantly increased to 14.1 +/- 3.0 fmol/ml (p <.05), L-754,142 produced a significant decreases in LV end-systolic pressure (101 +/- 11 versus 93 +/- 8 mm Hg) and total systemic resistance (0.084 +/- 0.022 versus 0.065 +/- 0.15 mm Hg/ml/min). The tau (42 +/- 12 versus 38 +/- 10 ms), mean left atrial P (22 +/- 5 versus 18 +/- 4 mm Hg) (p <.05), and minimum LVP were also significantly decreased. After CHF, the slopes of P-V relations, EES (3.4 +/- 0.4 versus 4.8 +/- 0.8 mm Hg/ml), dE/dtmax (42.4 +/- 7.8 versus 50.0 +/- 7.8 mm Hg/s/ml), and stroke work-end-diastolic V relation (58.1 +/- 3.3 versus 72.4 +/- 5.2 mm Hg) (p <.05) all increased after L-754,142, indicating enhanced contractility. Before CHF, low levels of endogenous ET-1 have little cardiac effect. However, after CHF, elevated endogenous ET-1 produces arterial vasoconstriction, slows LV relaxation, and depresses LV contractile performance. Thus, elevated endogenous ET-1 may contribute to the functional impairment in CHF in this canine model.  (+info)

Racial differences in the outcome of left ventricular dysfunction. (5/4972)

BACKGROUND: Population-based studies have found that black patients with congestive heart failure have a higher mortality rate than whites with the same condition. This finding has been attributed to differences in the severity, causes, and management of heart failure, the prevalence of coexisting conditions, and socioeconomic factors. Although these factors probably account for some of the higher mortality due to congestive heart failure among blacks, we hypothesized that racial differences in the natural history of left ventricular dysfunction might also have a role. METHODS: Using data from the Studies of Left Ventricular Dysfunction (SOLVD) prevention and treatment trials, in which all patients received standardized therapy and follow-up, we conducted a retrospective analysis of the outcomes of asymptomatic and symptomatic left ventricular systolic dysfunction among black and white participants. The mean (+/-SD) follow-up was 34.2+/-14.0 months in the prevention trial and 32.3+/-14.8 months in the treatment trial among the black and white participants. RESULTS: The overall mortality rates in the prevention trial were 8.1 per 100 person-years for blacks and 5.1 per 100 person years for whites. In the treatment trial, the rates were 16.7 per 100 person-years and 13.4 per 100 person-years, respectively. After adjustment for age, coexisting conditions, severity and causes of heart failure, and use of medications, blacks had a higher risk of death from all causes in both the SOLVD prevention trial (relative risk, 1.36; 95 percent confidence interval, 1.06 to 1.74; P=0.02) and the treatment trial (relative risk, 1.25; 95 percent confidence interval, 1.04 to 1.50; P=0.02). In both trials blacks were also at higher risk for death due to pump failure and for the combined end point of death from any cause or hospitalization for heart failure, our two predefined indicators of the progression of left ventricular systolic dysfunction. CONCLUSIONS: Blacks with mild-to-moderate left ventricular systolic dysfunction appear to be at higher risk for progression of heart failure and death from any cause than similarly treated whites. These results suggest that there may be racial differences in the outcome of asymptomatic and symptomatic left ventricular systolic dysfunction.  (+info)

Prevalence of hibernating myocardium in patients with severely impaired ischaemic left ventricles. (6/4972)

OBJECTIVE: Severe impairment of left ventricular (LV) contraction is associated with an adverse prognosis in patients with ischaemic heart disease. Revascularisation may improve the impaired LV contraction if hibernating myocardium is present. The proportion of patients likely to benefit from this intervention is unknown. Therefore, the prevalence of hibernating myocardium in patients with ischaemic heart disease and severe impairment of LV contraction was assessed. DESIGN: From a consecutive series of patients undergoing coronary angiography for the investigation of chest pain or LV impairment, all patients with ischaemic heart disease and an LV ejection fraction (LVEF) < or = 30% were identified. These patients underwent positron emission tomography (PET) to detect hibernating myocardium, identified by perfusion metabolism mismatch. SETTING: A teaching hospital directly serving 500,000 people. RESULTS: Of a total of 301 patients, 36 had ischaemic heart disease and an LVEF < or = 30%. Twenty-seven patients had PET images, while nine patients were not imaged because of emergency revascularisation (three), loss to follow up (one), inability to give consent (four), and age < 50 years (one, ethics committee guidelines). Imaged and non-imaged groups were similar in LV impairment, demographic characteristics, and risk factor profile. Fourteen patients (52% of the imaged or 39% of all patients with ischaemic heart disease and LVEF < or = 30%) had significant areas of hibernating myocardium on PET. CONCLUSION: It is possible that up to 50% of patients with ischaemic heart disease and severely impaired left ventricles have hibernating myocardium.  (+info)

Echo derived variables predicting exercise tolerance in patients with dilated and poorly functioning left ventricle. (7/4972)

OBJECTIVE: To determine whether resting echo derived measurements predict exercise tolerance and its interrelation with heart rate response and ventilation drive in patients with systolic left ventricular disease. DESIGN: Prospective echocardiographic examination followed by cardiopulmonary exercise testing. SETTING: A tertiary referral centre for cardiac diseases. SUBJECTS: 21 patients (11 with coronary artery disease, 10 with idiopathic dilated cardiomyopathy) with end diastolic dimension > 6.4 cm, shortening fraction < 25%, and in sinus rhythm. There were 11 age matched normal controls. RESULTS: In the patients, peak oxygen consumption (mVo2) correlated with right ventricular long axis excursion (r = 0.62); 65% of the variance in mVo2 was predictable using a multivariate model with right ventricular long axis excursion and peak lengthening rate, and peak mitral atrial filling velocity as independent variables. Aetiology was not an independent predictor, although the right ventricular long axis excursion (mean (SD)) was greater in patients with idiopathic dilated cardiomyopathy than in those with coronary artery disease (2.4 (0.5) cm v 1.6 (0.5) cm, p < 0.001). Peak heart rate correlated with duration of mitral regurgitation (r = -0.52) and the slope of ventilation against CO2 production correlated with M mode isovolumic relaxation time (r = 0.61). CONCLUSIONS: In patients with systolic left ventricular dysfunction, more than half the variance in exercise tolerance can be predicted by factors measured on echocardiography at rest, particularly right ventricular long axis excursion.  (+info)

Acute saline infusion reduces alveolar-capillary membrane conductance and increases airflow obstruction in patients with left ventricular dysfunction. (8/4972)

BACKGROUND: Impaired alveolar-capillary membrane conductance is the major cause for the reduction in pulmonary diffusing capacity for carbon monoxide (DLCO) in heart failure. Whether this reduction is fixed, reflecting pulmonary microvascular damage, or is variable is unknown. The aim of this study was to assess whether DLCO and its subdivisions, alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume (Vc), were sensitive to changes in intravascular volume. In addition, we examined the effects of volume loading on airflow rates. METHODS AND RESULTS: Ten patients with left ventricular dysfunction (LVD) and 8 healthy volunteers were studied. DM and Vc were determined by the Roughton and Forster method. The forced expiratory volume in 1 second (FEV1), vital capacity, and peak expiratory flow rates (PEFR) were also recorded. In patients with LVD, infusion of 10 mL. kg-1 body wt of 0.9% saline acutely reduced DM (12.0+/-3.3 versus 10.4+/-3.5 mmol. min-1. kPa-1, P<0.005), FEV1 (2.3+/-0.4 versus 2.1+/-0.4 L, P<0.0005), and PEFR (446+/-55 versus 414+/-56 L. min-1, P<0.005). All pulmonary function tests had returned to baseline values 24 hours later. In normal subjects, saline infusion had no measurable effect on lung function. CONCLUSIONS: Acute intravascular volume expansion impairs alveolar-capillary membrane function and increases airflow obstruction in patients with LVD but not in normal subjects. Thus, the abnormalities of pulmonary diffusion in heart failure, which were believed to be fixed, also have a variable component that could be amenable to therapeutic intervention.  (+info)

TY - JOUR. T1 - Exercise capacity in patients with severe left ventricular dysfunction. AU - Benge, John William. AU - Litchfield, R. L.. AU - Marcus, M. L.. PY - 1980/1/1. Y1 - 1980/1/1. N2 - Normal or near-normal exercise capacity has been thought to reflect normal left ventricular function. Many compensatory mechanisms could preserve exercise capacity in patients with severe left ventricular dysfunction. We evaluated exercise capacity using a treadmill exercise test in 26 patients with severe left ventricular dysfunction defined by a left ventricular ejection fraction of 30% or less by isotope ventriculography. One half of the patients had normal exercise capacity and a normal cardiothoracic ratio on chest x-ray. This study indicates that traditional predictors of left ventricular function that have been widely used in clinical evaluation of the patients with cardiac disease (cardiothoracic ratio and exercise capacity) can be normal in a significant number of patients with severe left ...
TY - JOUR. T1 - A Patient Presents with Longstanding, Severe LV Dysfunction. Is There a Role for Additional Risk Stratification Before ICD?. AU - Tereshchenko, Larisa. AU - Berger, Ronald D.. PY - 2012/6. Y1 - 2012/6. N2 - Increased longevity of patients with systolic heart failure caused by the use of implantable cardioverter-defibrillators (ICDs) is one of the most successful achievements in contemporary medicine. During the last 2 decades, the scientific community has striven to increase the benefits of ICD usage by specifying indications for primary prevention ICD implantation. Left ventricular ejection fraction is neither highly specific nor is it a highly sensitive risk marker of sudden cardiac death. The authors discuss risk-stratification approaches in different patient populations with structural heart disease and systolic heart failure.. AB - Increased longevity of patients with systolic heart failure caused by the use of implantable cardioverter-defibrillators (ICDs) is one of the ...
Background We assessed left ventricular dysfunction in a population at high risk for heart failure (HF), and explored associations between ventricular function, HF risk factors and NT-proB natriuretic peptide (NT-proBNP). Methods and results 3550 subjects at high risk for incident HF (= 60 years plus = 1 HF risk factor), but without pre-existing HF or left ventricular dysfunction, were recruited. Anthropomorphic data, medical history and blood for NT-proBNP were collected. Participants at highest risk (n = 664) (NT-proBNP highest quintile; , 30.0 pmol/L) and a sample (n = 51) from the lowest NT-proBNP quintile underwent echocardiography. Participants in the highest NT-proBNP quintile, compared to the lowest, were older (74 years vs. 67 years; p , 0.001) and more likely to have coronary artery disease, stroke or renal impairment. In the top NT-proBNP quintile (n = 664), left ventricular systolic impairment was observed in 6.6% (95% CI: 4 to 8%) of participants and was associated with male gender, ...
With the development of Dyssynchrony Imaging, Toshiba is providing cardiologists with a new innovation that expands the quantification capabilities of ultrasound to aid in diagnosing cardiovascular disease, said Gordon Parhar, director, Ultrasound Business Unit, Toshiba America Medical Systems, Inc. The DI method makes it easier for clinicians to determine the severity of dyssynchrony by having an automated detection of maximum values and a visual display of time to peak for each region. DI also will be a valuable tool in assessing patients for cardiac resynchronization therapy, providing clinicians with a pathway treatment from pre-implant to post implantation of the pacemaker ...
TY - JOUR. T1 - Normal left ventricular mechanical function and synchrony values by speckle-tracking echocardiography in the transplanted heart with normal ejection fraction. AU - Saleh, Haydar K.. AU - Villarraga, Hector R.. AU - Kane, Garvan C.. AU - Pereira, Naveen L.. AU - Raichlin, Eugenia. AU - Yu, Yang. AU - Koshino, Yuki. AU - Kushwaha, Sudhir S.. AU - Miller, Fletcher A.. AU - Oh, Jae K.. AU - Pellikka, Patricia A.. PY - 2011/6/1. Y1 - 2011/6/1. N2 - Background: The purpose of this study was to describe the normal values for strain (S), systolic strain rate (SRs) and synchrony by speckle-tracking echocardiography (STE) in heart transplant (HTx) recipients who had normal left ventricular ejection fraction (LVEF) and no clinically significant complications. Methods: We evaluated S and SRs in 40 HTx patients at 1 year after transplant and 82 healthy controls with STE using velocity vector imaging. Results: Mean (SD) global longitudinal S and SRs, respectively, were lower in the transplant ...
Left ventricular dysfunction is a major determinant of outcome in coronary artery disease.1 However, not all dyssynergic areas are irreversibly damaged after infarction, as left ventricular dysfunction may be caused by myocardial stunning2 or by chronic reduction of blood flow,3 and the segments involved may show improved function after restoration of blood flow.4 Preservation of metabolism despite reduced function is the cornerstone of viable myocardium, but ultrastructural changes have been documented in viable tissue, including loss of sarcoplasmic reticulum, small scattered mitochondria, and glycogen deposition.5 These changes suggest a reduction in aerobic metabolism, but glucose uptake and utilisation are preserved and indeed have been used as a diagnostic marker of viability.6. Because of co-morbidity, myocardial revascularisation may be difficult to achieve in many patients with left ventricular dysfunction and viable myocardium. In these situations, medical treatment to improve left ...
BACKGROUND: Cardiac magnetic resonance imaging (CMR) has been established as a powerful tool for predicting mortality. However, its application is limited by availability and various contraindications. The aim of this study was to evaluate the predictive value of layer-specific myocardial deformation analysis as assessed by strain echocardiography for cardiac events in patients with chronic ischemic left ventricular dysfunction in comparison with CMR. METHODS: Three hundred ninety patients (mean age, 63 ± 4 years; 69% men; mean left ventricular ejection fraction [LVEF], 41 ± 7%) with chronic ischemic cardiomyopathy were prospectively enrolled and underwent strain echocardiography and CMR within 3 ± 1 days ...
Background-Limited data exist on the prevalence, associations and prognosis of individuals with asymptomatic left ventricular systolic dysfunction (ALVSD), especially in populations without prior clinical cardiovascular disease (CVD). Methods and Results-Kaplan-Meier and Cox proportional hazard analyses were used to assess the association between ALVSD, defined as left ventricular ejection fraction less than 50%, and adjudicated incident congestive heart failure (CHF), all-cause mortality, and CVD events. Out of 5004 participants, 112 participants had CHF, 321 had a CVD event, and 278 died after 9 years of follow-up. The overall prevalence of ALVSD was 1.7%, with a higher prevalence in African Americans (2.6%). ALVSD had worse cardiovascular risk profile and was also associated with increased risk in unadjusted and adjusted models for incident CHF [HR (95%): 12.0(7.04-20.3), p,0.0001 and 8.69(4.89-15.45), p,0.001 respectively], CVD [HR (95%):3.32(1.98-5.58), p,0.001 and 2.21(1.30-3.73), p=0.003 ...
TY - JOUR. T1 - Subclinical Left Ventricular Dysfunction is Influenced by Genotype Severity in Patients with Cystic Fibrosis. AU - Pallin, Michael. AU - Keating, Dominic. AU - Kaye, David M.. AU - Kotsimbos, Tom. AU - Wilson, John W.. PY - 2018/8/1. Y1 - 2018/8/1. N2 - Background and objective: Over 2000 genotypes in the cystic fibrosis (CF) gene have been described. These genotypic differences result in variable clinical manifestations of CF, with severity of disease dependent on CF transmembrane conductance (CFTR) protein function. CFTR is widely distributed in nucleated cells, including cardiac myocytes, but the effect of genotype on cardiac function is not known. Methods: This retrospective review of echocardiographic data is from a single adult CF centre between 2000 and 2015. Patients were cohorted based on the functional classification of genotype. Severe patients had both CF genes from functional classification groups 1-3; mild patients had one or no gene from these groups, or in the ...
To study the mechanisms of myocardial ischemia during isometric exercise, handgrip was sustained, for 4.5 min at 25% of maximum by 11 patients with at least one significant coronary stenosis each, during cardiac catheterization. After recovery, the handgrip that was repeated with simultaneous infusion of nitroglycerin (50 micrograms over 4 min) directly into the diseased vessel. The cardiovascular response was assessed by hemodynamic and by computer-assisted measurements of stenosis. During the first handgrip test pulmonary capillary wedge pressure rose 56% (15 to 23 mm Hg; p less than .001), the heart rate-systolic pressure product rose 33% (p less than .01), and the diseased epicardial arteries constricted. Luminal area in the stenotic segment was reduced by 35% (p less than .01), resulting in a 243% increase in estimated stenotic flow resistance (30 to 103 mm Hg/ml/sec; p less than .001). During handgrip with intracoronary nitroglycerin, the pressure-rate product again increased 33%, but ...
There is increasing evidence that transient ischemia in humans can affect myocardial function in similar patterns to those described in experimental animal models. In dogs, demand ischemia triggers both stunning (reversible contractile dysfunction despite the return of normal myocardial perfusion) and ischemic preconditioning (protection against infarction caused by subsequent coronary occlusion) (1,2). In patients with angina, myocardial contractile function may remain depressed for up to 30 min after the completion of exercise, and this may represent stunning (3-5). Patients may also develop less anginal pain and electrocardiographic (ECG) evidence of ischemia during sequential exercise testing: the warm-up phenomenon (6). It is hypothesized that this may represent a form of ischemic preconditioning.. There are important differences of definition between the warm-up effect and ischemic preconditioning. The former involves protection against indirect markers of ischemia (chest pain and ECG ...
TY - JOUR. T1 - Impact of ventricular dyssynchrony on postexercise accommodation of systolic myocardial motion in hypertensive patients with heart failure and a normal ejection fraction. T2 - A tissue-Doppler echocardiography study. AU - Wang, Yi Chih. AU - Yu, Chih Chieh. AU - Chiu, Fu Chun. AU - Klepfer, Ruth. AU - Hilpisch, Kathryn. AU - Splett, Vincent. AU - Tsai, Chia Ti. AU - Lai, Ling Ping. AU - Hwang, Juey Jen. AU - Lin, Jiunn Lee. PY - 2012/2/1. Y1 - 2012/2/1. N2 - Background: We hypothesized left ventricular (LV) dyssynchrony would affect postexercise accommodation of regional myocardial motion in patients with heart failure and a normal ejection fraction (HFNEF). Methods and Results: Tissue-Doppler echocardiography was studied in 100 hypertensive patients with LV ejection fraction ,50%. Among them, 70 HFNEF patients were classified into the systolic dyssynchrony (Dys: ,65 ms difference of electromechanical delay between septal and lateral segments) (43 patients) and nondyssynchrony ...
Clinical trial for NIDDM , Teneligliptin on the Progressive Left Ventricular Diastolic Dysfunction With Type 2 Diabetes Mellitus Study
Exercise-induced left ventricular regional wall motion abnormalities among patients with coronary artery disease indicate myocardial ischemia due to significant coronary artery narrowing. Recovery of such stress-induced wall motion abnormalities is thought to occur within minutes after the termination of exercise. However, in some patients, persistent contractile dysfunction has been observed up to 90 minutes into recovery. Whether persistent regional wall motion abnormalities after exercise are due to stunned myocardium (prolonged but reversible postischemic dysfunction despite restoration of blood flow) or persistent ischemia due to coronary vasoconstriction (prolonged postischemic dysfunction due to persistent reduction of regional blood flow) is not well established. It is possible that persistent but reversible left ventricular dysfunction post-exercise may represent persistent reduction in regional blood flow and/or altered regional metabolic state.. In this protocol, we intend to ...
Predictive value of microvolt T-wave alternans in patients with left ventricular dysfunction. J Am Coll Cardiol. 2007 Jul 10; 50(2):166-73 ...
There were 376 of the total 528 patients in the Newcastle 85+ Study with echocardiography data who were included in the analysis. The mean patient age was 87.9 ± 0.4 years, 62% were female, 44% had a history of ischemic heart disease, 58% hypertension, 2.7% severe renal failure, and 13% had diabetes. LV systolic dysfunction (ejection fraction [EF] ≤50%) was present in 32% (n = 119/376) and 20% had moderate or severe LV diastolic dysfunction with a preserved LVEF. Limiting dyspnea was reported in 63% of patients (n = 57/90) with systolic dysfunction and 60% (n = 30/50) of patients with moderate or severe diastolic dysfunction. Only 10% of patients identified to have systolic heart failure (HF) or moderate/severe diastolic dysfunction carried a pre-existing diagnosis of HF; 26% of patients with limiting dyspnea had undiagnosed LVD.. ...
EFFECT OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION ON CEREBRAL HEMODYNAMICS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION (THE RESULTS OF OBSERVATIONAL STUDIES)
The aim of the present study was to measure regional ventricular function at rest and during stress in order to assess if patients with Type II diabetes have subclinical myocardial dysfunction and if it is related to risk factors. Seventy subjects (35 patients with Type II diabetes with no symptoms, signs or history of heart disease, and 35 age- and sex-matched healthy controls) had echocardiography at rest and during dobutamine stress. Myocardial velocities were measured off-line from digital loops of colour tissue Doppler. Subendocardial function was assessed from the mean longitudinal velocities of four basal segments (apical views) and radial function from the velocities of the basal posterior wall (parasternal view). Systolic functional reserve was calculated as the increase in velocity from baseline. Longitudinal peak systolic velocity was lower in patients with diabetes, at rest (5.6±1.4 compared with 6.5±1.1 cm/s) and at peak stress (10.9±2.8 compared with 14.3±2.1 cm/s) (both ...
Reversible left ventricular dysfunction after an episode of ventricular tachycardia has been reported (3). Rapid ventricular pacing in animal models has also been shown to result in transient dysfunction of the left ventricle (4). Although the specific apical ballooning has not been mentioned in these reports, the reversible character of the ventricular dysfunction is a sufficient argument for the addition of this entity to the exclusion criteria ...
Results ALVDD was associated with higher serum natriuretic peptide, matrix metalloproteinase (MMP)-2, LAVi and left ventricular mass index versus Comparators at baseline. All patients had mean ejection fraction (EF) 67 ± 8%.. Over the follow-up duration, persistent AVLDD was associated with greater increase in monocyte chemoattractant protein-1 (924.6 ± 2420.3 vs 198.5 ± 239.4 pg/ml) and aortic root diameter (0.27 ± 0.45 vs 0.06 ± 0.27 cm) with reduction in EF (-5.4 ± 5.2 vs -0.2 ± 7.0%) versus others; all p , 0.05. Despite within-group reductions in LAVi in both groups supported by increase in anti-hypertensives with blood pressure and MMP-2 lowering, there was a significant increase in interleukin-8 and tumour necrosis factor-alpha over follow-up. ...
The reasons for concentrating on the earliest stages of HF stems from the common idea that this condition is more susceptible to reversal and also from the data of the EMPAREG OUTCOME trial showing the more robust effects, both in terms of hospitalization for HF and cardiovascular death, in the patients without HF at baseline or diagnosed during the study [10]. We therefore focused on patients with normal EF without current or prior symptoms of overt HF, but at high risk for the condition for presence of T2D and allowing for arterial hypertension and structural (LV hypertrophy) or functional (diastolic dysfunction) or biochemical (NT-pro-BNP) evidence of initial myocardial disease (Stage A and B HF according to ACC/AHA guidelines). In terms of pathophysiological changes the data are essentially based on few experimental studies and speculations [49]. SGLT2 inhibitors might actually affect myocardial functions through mechanisms that can act both directly and indirectly on the myocardium. Chronic ...
Introduction Left ventricular systolic dysfunction and elevated serum interleukins (ILs) are common in septic patients. However, whether left ventricular diastolic dysfunction is related to mortality in septic patients is a matter of debate. Aim The aim of the study was to assess the effect of myocardial systolic and diastolic functions on mortality in cases of sepsis and to predict an inflammatory marker that could be clearly linked to mortality in sepsis. Patients and methods Twenty patients were prospectively studied, with measurement of the following on admission and on day 7: left ventricular end-diastolic volume, left ventricular end-systolic volume, left ventricular ejection fraction% (echocardiography), mitral annulus S-velocity, Ed/t, and serum levels of ILs (IL-1α, IL-1β, IL-6, and IL-10). Mortality on day 28 was the study endpoint. Results Twenty patients with sepsis and septic shock were studied (45% were male and 55% were female; mean age 52±17 years). The patients were divided ...
Introduction Left ventricular systolic dysfunction and elevated serum interleukins (ILs) are common in septic patients. However, whether left ventricular diastolic dysfunction is related to mortality in septic patients is a matter of debate. Aim The aim of the study was to assess the effect of myocardial systolic and diastolic functions on mortality in cases of sepsis and to predict an inflammatory marker that could be clearly linked to mortality in sepsis. Patients and methods Twenty patients were prospectively studied, with measurement of the following on admission and on day 7: left ventricular end-diastolic volume, left ventricular end-systolic volume, left ventricular ejection fraction% (echocardiography), mitral annulus S-velocity, Ed/t, and serum levels of ILs (IL-1α, IL-1β, IL-6, and IL-10). Mortality on day 28 was the study endpoint. Results Twenty patients with sepsis and septic shock were studied (45% were male and 55% were female; mean age 52±17 years). The patients were divided ...
TY - JOUR. T1 - Usefulness of echocardiography in detecting left ventricular dysfunction in population-based studies (The Rotterdam study). AU - Mosterd, Arend. AU - De Bruijne, Martine C.. AU - Hoes, Arno W.. AU - Deckers, Jaap W.. AU - Hofman, Albert. AU - Grobbee, Diederick E.. PY - 1997/1/1. Y1 - 1997/1/1. UR - http://www.scopus.com/inward/record.url?scp=0030640869&partnerID=8YFLogxK. U2 - 10.1016/S0002-9149(96)00691-1. DO - 10.1016/S0002-9149(96)00691-1. M3 - Article. C2 - 9024752. AN - SCOPUS:0030640869. VL - 79. SP - 103. EP - 104. JO - American Journal of Cardiology. JF - American Journal of Cardiology. SN - 0002-9149. IS - 1. ER - ...
Reviews and ratings for lotensin when used in the treatment of left ventricular dysfunction. Share your experience with this medication by writing a review.
The effectiveness of strategies for treatment of the altered static lung volume and against the development of bronchial hyperreactivity (BHR) following a left ventricular dysfunction (LVD) induced by myocardial ischaemia was investigated in a rat model of sustained postcapillary pulmonary hypertension. Airway resistance (Raw) was identified from the respiratory system input impedance (Zrs) in four groups of rats. End-expiratory lung volume (EELV) was determined plethysmographically, and Zrs was measured under baseline conditions and following iv infusions of 2, 6 or 18 μg/kg/min methacholine. Sham surgery was performed in the rats in Group C, while the left interventricular coronary artery was ligated and Zrs and its changes following identical methacholine challenges were reassessed in the same rats 8 weeks later, during which no treatment was applied (Group I), or the animals were treated daily with a combination of an angiotensin enzyme converter inhibitor and a diuretic (enalapril and furosemide,
This page includes the following topics and synonyms: Systolic Dysfunction, Left Ventricular Dysfunction, Left Ventricular Failure, Systolic Heart Failure, Left Ventricular Systolic Dysfunction, Heart Failure with Reduced Ejection Fraction.
BACKGROUND:In patients with left ventricular dysfunction one of the aims of therapy may be to improve functional capacity. This study compared the improvement of functional capacity in response to medical therapy with that caused by revascularization. METHODS:Fifty-two patients with severe left ventricular dysfunction were divided into groups with ischemic cardiomyopathy undergoing revascularization (group A, n = 20) or incremental medical treatment (group B, n = 16) and a control group receiving maximal medical therapy at the start of the study (group C, n = 16). All patients underwent a baseline metabolic exercise test with evaluation of peak oxygen consumption and derived exercise capacity in metabolic equivalents (METS) with standard electrocardiographic and hemodynamic monitoring. Therapy was then optimized in the medical treatment group, whereas the revascularization group underwent coronary bypass grafting. All patients subsequently underwent follow-up metabolic exercise testing. ...
The objective of the project is to study clinical and prognostic value of new echocardiographic technique, so called positive preejection velocity (+VIC), in patients with chronic ischemic left ventricular (LV) dysfunction indicated for revascularization. Pilot studies has shown high accuracy of pulsed Tissue Doppler imaging (TDI)-derived resting pattern of +VIC to detect viable myocardium in patients with both acute myocardial infarction and chronically dysfunctional myocardium. The aim of the project is to test accuracy of +VIC to predict LV remodeling and long-term prognosis after revascularization in patients with chronically dysfunctional myocardium. Study population will consist of two groups of patients with stable ischemic LV dysfunction: group A- patients indicated for revascularization (n=200), group B- matched control group treated conservatively (case-control design) (n=100). All patients will be followed for 3 years. Endpoints include: 1) LV remodeling at 6 and 24 months and 2) MACE ...
Introduction. Assessing left ventricular (LV) systolic function in a rapid and reliable way can be challenging in the critically ill patient. The purpose of this study was to evaluate the feasibility and reliability of, as well as the association between, commonly used LV systolic parameters, by using serial transthoracic echocardiography (TTE).. Methods. Fifty patients with shock and mechanical ventilation were included. TTE examinations were performed daily for a total of 7 days. Methods used to assess LV systolic function were visually estimated, eyeball ejection fraction (EBEF), the Simpson single-plane method, mean atrioventricular plane displacement (AVPDm), septal tissue velocity imaging (TDIs), and velocity time integral in the left ventricular outflow tract (VTI).. Results. EBEF, AVPDm, TDIs, VTI, and the Simpson were obtained in 100%, 100%, 99%, 95% and 93%, respectively, of all possible examinations. The correlations between the Simpson and EBEF showed r values for all 7 days ...
Nonalcoholic fatty liver illness (NAFLD) can be a issue [[http://​robertfkennedyjr.net/​form-two-diabetes-induce-and-remedy/​,http://​www.diettalk.com]] ​ wherein the liver has as well substantially unwanted fat. Commonly it can be not deadly, but it surely may become infected. In nondiabetics it has been related to a heart disorder regarded as left ventricular diastolic dysfunction. The remaining ventricle on the heart pumps blood coming from the lungs via the still left atrium. Blood pumped through the remaining ventricle travels in the aorta, a big artery, from where by it travels throughout the body. In left ventricular diastolic dysfunction,​ LVDD, the left ventricle does not fill thoroughly involving beats. This may trigger fluid to again up in the still left atrium together with the lungs. This problem is known as heart failure. Investigators at College and Azienda Ospedaliera Universitaria Integrata of Verona and other investigate centers in Italy, executed a examine to ...
Most studies of chemotherapy-induced cardiotoxicity have focused on the treatment of patients with heart failure or LVSD (2,7,18). In these patients, the current clinical practice is to stop chemotherapy and to restart it after LV recovery and to avoid further use of anthracyclines. However, even if LVSD improves after treatment, patients with chemotherapy-induced cardiotoxicity are prone to further deterioration in their LV function when confronted with further cycles of chemotherapy or even under stress conditions (19). Hence, in patients with cancer, the main objective should be to prevent rather than to treat cardiac toxicity (20).. ACEI have been shown to be effective against chemotherapy-induced cardiotoxicity in animal models (8,9). Although their use to prevent the progression of LVSD was disappointing in a study of pediatric cancer (18), a recent study reported favorable results when administered to adult patients with chemotherapy-induced cardiac toxicity (10). Positive results have ...
Physiological effects of percutaneous interventions / Coronary stenting in challenging cases 1244 , Loss of functional recovery In regional wall motion Is predictive for restenosis of the supplying angloplasty vessel - follow-up echocardtographlc study after high-risk angloplasty Adrian C. Borges, Franz Xaver Kleber, Dorothee SchOrger, Qert Baumann, Rosa Sicari, Alessandro Plngitore, Eugenio Rcano 1 . Medical Department I, Humbotdt-Unlverslty BerSn (Charite), Germany;1 Physiologic CSnic, CNR Pisa, Italy, on behalf of the VIDA (Viability Identification with Dobutantine-CHpyiidamote Adrrfnistmtion}Study Group The prediction of functional regional recovery Is possible wtth pharmacological stress echocarcbography and has In patients with severe left ventricular dysfunction and coronary artery disease a great prognostic Impact The aim of the study was to evaluate If the loss of recovery of regional left ventricular function after successful revascuiarization can predict a restenosis of the target ...
Over the past 1.5 decades, numerous stem cell trials have been performed in patients with cardiovascular disease. Although encouraging outcome signals have been reported, these have been small, leading to uncertainty as to whether they will translate into significantly improved outcomes. A reassessment of the rationale for the use of stem cells in cardiovascular disease is therefore timely. Such a rationale should include analyses of why previous trials have not produced significant benefit and address whether mechanisms contributing to disease progression might benefit from known activities of stem cells. The present paper provides such a reassessment, focusing on patients with left ventricular systolic dysfunction, either nonischemic or ischemic. We conclude that many mechanisms contributing to progressive left ventricular dysfunction are matched by stem cell activities that could attenuate the myocardial effect of such mechanisms. This suggests that stem cell strategies may improve patient ...
Right ventricular apical (RVA) pacing results in abnormal left ventricular (LV) electrical and mechanical activation and is associated with an
Satoshi Shizuta, Kenji Ando, Masakiyo Nobuyoshi, Takanori Ikeda, Hideaki Yoshino, Shinichi Hiramatsu, Yukio Kazatani, Kohei Yamashiro, Katsunori Okajima, Teishi Kajiya, Yoshinori Kobayashi, Takao Kato, Satoki Fujii, Kazuaki Mitsudo, Koichi Inoue, Hiroshi Ito, Yoshisumi Haruna, Takahiro Doi, Yukiko Nishio, Neiko ...
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Background: Left ventricular diastolic dysfunction (LVDD) is a common abnormality among patients in T2DM. Aims: We aimed to evaluate the feasibility
Measurement of BNP could be a cost-effective method of screening for left-ventricular systolic dysfunction in the general population, especially if its use were targeted to individuals at high risk.
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Al Ruzzeh S, Athanasiou T, George S, et al. 2003. Is the use of cardiopulmonary bypass for multivessel coronary artery bypass surgery an independent predictor of operative mortality in patients with ischemic left ventricular dysfunction? Ann Thorac Surg 76:444-51.nArom KV, Flavin TF, Emery RW, et al. 2000. Is low ejection fraction safe for off-pump coronary bypass operation? Ann Thorac Surg 70:1021-5.nAscione R, Narayan P, Rogers CA, et al. 2003. Early and midterm clinical outcome in patients with severe left ventricular dysfunction undergoing coronary artery surgery. Ann Thorac Surg 76:793-9.nBouchart F, Tabley A, Litzler PY, et al. 2001. Myocardial revascularization in patients with severe ischemic left ventricular dysfunction: long term follow-up in 141 patients. Eur J Cardiothorac Surg 20:1157-62.nCarr JA, Haithcock BE, Paone G, et al. 2002. Long-term outcome after coronary artery bypass grafting in patients with severe left ventricular dysfunction. Ann Thorac Surg 74:1531-6.nCox DR. 1972. ...
TY - JOUR. T1 - The natural history of isolated left ventricular diastolic dysfunction. AU - Brogan, Walter C.. AU - Hillis, L. David. AU - Flores, Eduardo D.. AU - Lange, Richard A.. PY - 1992. Y1 - 1992. N2 - study objective: To assess the natural history of isolated left ventricular diastolic dysfunction. materials and methods: Follow-up (average duration, 68 months) was obtained in 51 patients with isolated left ventricular diastolic dysfunction at cardiac catheterization, characterized by (1) an elevated left ventricular end-diastolic pressure; (2) normal left ventricular end-diastolic and end-systolic volumes; (3) normal left ventricular ejection fraction; (4) no coronary artery disease; and (5) no valvular disease. results: During follow-up, seven patients died, but only one died of cardiac causes. Of the 44 living subjects, 20 (45%) noted new-onset symptoms of congestive heart failure, with 11 (25%) of these requiring hospitalization, and 12 (27%) required hospitalization for recurrent ...
Cardiac-resynchronization therapy (CRT) has known benefits in patients with severe left ventricular systolic dysfunction and prolonged QRS duration (,120 ms). However, up to half of patients with systolic dysfunction appear to have left ventricular dyssynchrony by echocardiographic measures, despite a QRS duration of less than 120 ms. As a result, CRT is often used for patients with echocardiographic evidence of dyssynchrony and a narrow QRS complex, despite a lack of clear benefit to this approach. The Echocardiography Guided Cardiac Resynchronization Therapy (EchoCRT) study sought to determine the effect of CRT on patient outcomes in the setting of symptomatic heart failure, echocardiographic findings of dyssynchrony, and QRS duration ,120 ms.. In this multicenter double blind trial, patients with severe symptomatic left ventricular failure (EF,35% and NYHA class III or IV) with a QRS duration of ,130ms (mean 105ms) and evidence of dyssynchrony either on tissue Doppler or speckle tracking echo ...
TY - JOUR. T1 - Left Ventricular Diastolic Dysfunction in Peritoneal Dialysis. AU - Wu, Cho Kai. AU - Lee, Jen Kuang. AU - Wu, Yi Fan. AU - Tsai, Chia Ti. AU - Chiang, Fu Tien. AU - Hwang, Juey Jen. AU - Lin, Jiunn Lee. AU - Hung, Kuan Yu. AU - Huang, Jenq Wen. AU - Lin, Jou Wei. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Left ventricular diastolic dysfunction (LVDD) is common among patients undergoing peritoneal dialysis (PD). We examined the relationship between LVDD, major adverse cardiovascular events (MACE), and mortality in PD patients. A total of 149 patients undergoing PD with preserved left ventricular systolic function were included and followed for 3.5 years. LVDD was diagnosed (according to the European Society of Cardiology guidelines) by conventional and tissue Doppler echocardiography. Serum high-sensitivity C-reactive protein (hsCRP) was measured. The location and volume of adipose tissue were assessed by computed tomography (CT) at the level of the fourth lumbar vertebra. Subjects with ...
Abstract Mitral valve leaflets in patients with chronic heart failure are severely stiffened, larger and fibrotic; though the mechanisms underlying such biological remodeling are currently unknown. Chronic tethering of the valve leaflets by the enlarged left ventricle, and the presence of mitral regurgitation (MR), is hypothesized to trigger fibrotic pathways that induce such remodeling. In this study, we sought to develop a large animal model of chronic ischemic left ventricular failure in which moderate leaflet tethering and MR can be repeatedly induced, and the remodeling of the mitral valve can be assessed in vivo using echocardiography. Inferior wall myocardial infarction (IMI) was induced in 16 farm swine (30-35kg) using a percutaneous transfemoral approach. Coronary angiography was performed to selectively identify the marginal branches of the left circumflex artery perfusing the inferior left ventricular (LV) wall and the posterior papillary muscle (PPM), and then these regions were infarcted
Results Conventional echocardiographic measurements (LV end diastolic diameter, LV end systolic diameter and LV EF) were similar between the groups. Longitudinal peak systolic strain (13.20±3.5% to 20.97±4.5%, p=0.0001) and strain rate (0.23±0.18 1/s to 4.92±0.55 1/s, p=0.0001) of the LV were significantly impaired in patients with TA, compared to controls, demonstrating subclinical ventricular systolic dysfunction. Supporting these results, we revealed impaired subclinical LV systolic function in patients with SLE, when compared to the control group (14±4.53% to 20.97±4.5%, p=0.0001 for strain; 0.23±0.12 1/s to 4.92±0.55 1/s, p=0.0001 for strain rate). The mean disease duration of the patient was 5.6 years in patients with TA. The LV systolic dysfunction was negatively correlated with disease duration, but this correlation couldnt reach the statistical significance(r=-0,085, p=0,648.). ...
TY - JOUR. T1 - Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction results of the SOLVD echocardiography substudy. AU - Greenberg, Barry. AU - Quinones, Miguel A.. AU - Koilpillai, Chris. AU - Limacher, Marian. AU - Shindler, Daniel. AU - Benedict, Claude. AU - Shelton, Brent. PY - 1995/5/15. Y1 - 1995/5/15. N2 - Background: Studies of Left Ventricular Dysfunction (SOLVD) demonstrated that enalapril therapy significantly improved the clinical course of patients with left ventricular (LV) dysfunction. The goals of this substudy were to evaluate changes in LV structure and function in SOLVD patients and to test the hypothesis that enalapril inhibits remodeling in patients with LV dysfunction. Methods and Results: Patients entering both the prevention and treatment arms of SOLVD from 5 of the 23 clinical centers were recruited for this substudy. The 301 patients who participated underwent Doppler-echocardiographic evaluation ...
TY - JOUR. T1 - New-Onset Heart Failure and Mortality in Hospital Survivors of Sepsis-Related Left Ventricular Dysfunction. AU - Vallabhajosyula, Saraschandra. AU - Jentzer, Jacob C.. AU - Geske, Jeffrey B.. AU - Kumar, Mukesh. AU - Sakhuja, Ankit. AU - Singhal, Akhil. AU - Poterucha, Joseph T.. AU - Kashani, Kianoush. AU - Murphy, Joseph G.. AU - Gajic, Ognjen. AU - Kashyap, Rahul. PY - 2017/7/19. Y1 - 2017/7/19. N2 - BACKGROUND:: The association between new-onset left ventricular (LV) dysfunction during sepsis with long-term heart failure outcomes is lesser understood. METHODS:: Retrospective cohort study of all adult patients with severe sepsis and septic shock between 2007 and 2014 that underwent echocardiography within 72?hours admitted to the intensive care unit. Patients with prior heart failure, LV dysfunction, and structural heart disease were excluded. LV systolic dysfunction was defined as LV ejection fraction ,50% and LV diastolic dysfunction as ≥grade II. Primary composite outcome ...
TY - JOUR. T1 - Recovery from left ventricular dysfunction was associated with the early introduction of heart failure medical treatment in cancer patients with anthracycline-induced cardiotoxicity. AU - Ohtani, Kisho. AU - Fujino, Takeo. AU - Ide, Tomomi. AU - Funakoshi, Kouta. AU - Sakamoto, Ichirou. AU - Hiasa, Ken ichi. AU - Higo, Taiki. AU - Kamezaki, Kenjiro. AU - Akashi, Koichi. AU - Tsutsui, Hiroyuki. PY - 2019/6/1. Y1 - 2019/6/1. N2 - Background: Left ventricular (LV) dysfunction due to anthracycline-induced cardiotoxicity (AIC) has been believed to be irreversible. However, this has not been confirmed and standard medical treatment for heart failure (HF) including renin-angiotensin inhibitors and β-blockers may lead to its recovery. Methods and results: We thus retrospectively studied 350 cancer patients receiving anthracycline-based chemotherapy from 2001 to 2015 in our institution. Fifty-two patients (14.9%) developed AIC with a decrease in LV ejection fraction (LVEF) of 24.1% at a ...
Ethanol consumption is associated with left ventricular dysfunction in heavy ethanol drinkers. The effect of moderate ethanol intake on left ventricular function in hypertension, however, is unknown. We investigated the relationship between ethanol consumption and cardiac changes in nonalcoholic hypertensive patients. In 335 patients with primary hypertension, we assessed daily ethanol consumption by questionnaires that combined evaluation of recent and lifetime ethanol exposure and examined cardiac structure and function by echocardiography. Patients with abnormal liver tests, previous cardiovascular events, left ventricular ejection fraction ,50%, and creatinine clearance ,30 mL/min 1.72 m2 were excluded. Left ventricular hypertrophy was found in 21% of hypertensive patients and diastolic dysfunction was detected in 50% by tissue-Doppler imaging. Ethanol consumption was comparable in hypertensive patients with and without left ventricular hypertrophy, whereas patients with left ventricular ...
Objective Cardiac syndrome X defines patients with typical angina, a positive exercise ECG stress test and angiographically documented normal coronary arteries. In previous studies, post-stress prolonged left ventricular dysfunction (PLVD) using gated SPECT (G-SPECT) had been well correlated with myocardial perfusion abnormalities and degree of stenotic vessels in CAG in patients with coronary artery disease. However, evaluation of left ventricular myocardial perfusion, wall motion and left ventricular ejection fraction (LVEF) in patients with cardiac syndrome X, using G-SPECT had not been studied yet. Thus, the aim of this study was to analyse PLVD using (99m)Tc-MIBI GSPECT in patients with cardiac syndrome X. ...
Treatment with enalapril for 3-4 years led to a sustained improvement in survival beyond the original trial period in patients with left ventricular systolic dysfunction, with an important increase in life expectancy.
Long-term RV pacing leads to ventricular dyssynchrony, in the form of LBBB-like morphology, with subsequent detrimental effects on LV structure and function. Three-dimensional echocardiography allowed early detection of volumetric changes associated with PICMP and provided more accurate assessment of mechanical dyssynchrony. Speckle tracking strain is able to identify LV dysfunction even before any reduction in LVEF. Our aim was to study pacing effects on LV function and hemodynamics using 3D echo and speckle tracking strain. This was a prospective study of 175 consecutive patients without structural heart disease (LVEF | 50%) presented for permanent pacing. Full-volume 3D echocardiography done before implantation, 1 week, and 6 months together with GLS. Patients were followed for 6 months to detect incidence of PIVD (defined as reduction in LVEF | 10% but still above 50%) and PICMP (defined as decrease in LVEF by 10% from baseline in absence of other known causes of cardiomyopathy resulting in EF| 50%)
The CHARM study extends our knowledge of the role of ARBs in patients with CHF.. Least surprising but still important was the finding in the CHARM-Alternative study that candesartan resulted in a significant reduction in cardiovascular mortality and heart failure hospitalization. The Valsartan Heart Failure Trial (ValHeFT) (1) reached a similar conclusion, and valsartan is indicated in patients with heart failure caused by systolic left ventricular dysfunction who are not taking an ACE inhibitor. However, the result of ValHeFT was determined in a retrospective analysis and included a relatively small number of patients and events. The CHARM-Alternative study, on the other hand, was prospective and adequately powered with a significant number of events. It is likely that ARBs used at the appropriate dose, such as valsartan 160 mg twice daily or candesartan 32 mg daily, are equivalent to target doses of an ACE inhibitor, such as enalapril 10 mg twice daily. However, the therapy of choice in ...
Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004;89(6):2745-9.http://dx.doi.org/10.1210/jc.2003-032046. Hart R, Hickey M, Franks S. Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol 2004;18(5):671-83.http://dx.doi.org/10.1016/j.bpobgyn.2004.05.001. Schannwell CM, Schneppenheim M, Perings S, Plehn G, Strauer BE. Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy. Cardiology 2002;98(1-2):33-9.http://dx.doi.org/10.1159/000064682. Brutsaert DL, Sys SU, Gillebert TC. Diastolic failure: Pathophysiology and therapeutic implications. J Am Coll Cardiol 1993;22(1):318-25.http://dx.doi.org/10.1016/0735-1097(93)90850-Z. Watts GF, Marwick TH. Ventricular dysfunction in early diabetic heart disease: Detection, mechanisms and significance. Clin Sci ...
TY - JOUR. T1 - Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction. AU - Pawlinski, R.. AU - Fernandes, A.. AU - Kehrle, B.. AU - Pedersen, B.. AU - Parry, G.. AU - Erlich, J.. AU - Pyo, R.. AU - Gutstein, D.. AU - Zhang, J.. AU - Castellino, F.. AU - Melis, E.. AU - Carmeliet, P.. AU - Baretton, G.. AU - Luther, T.. AU - Taubman, M.. AU - Rosen, E.. AU - Mackman, N.. PY - 2002/11/26. Y1 - 2002/11/26. N2 - Exposure of blood to tissue factor (TF) activates the extrinsic (TF: FVIIa) and intrinsic (FVIIIa:FIXa) pathways of coagulation. In this study, we found that mice expressing low levels of human TF (≈1% of wild-type levels) in an mTF-/- background had significantly shorter lifespans than wild-type mice, in part, because of spontaneous fatal hemorrhages. All low-TF mice exhibited a selective heart defect that consisted of hemosiderin deposition and fibrosis. Direct intracardiac measurement demonstrated a 30% reduction (P , 0.001) in left ventricular function in ...
Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers. The newly designed Amplatzer vascular plug is undergoing clinical trials. SLY2 and SLY12 encode proteins with hydrophobic tails similar to synaptobrevins, integral membrane proteins of synaptic vesicles in higher eucaryotes. This prospective, randomized, single-blinded study examined 70 ASA III patients undergoing elective ambulatory varicose vein surgery. The effects of pharmacological treatment in asymptomatic left ventricular dysfunction Population data of 15 autosomal STR loci in Chinese Han population from Jiangsu Province, Eastern China.. Effects of lamivudine and thymosin alpha1 combination therapy on patients with chronic hepatitis B Costs of occupational asthma and of occupational chronic obstructive pulmonary disease. SAM recognition and conformational switching mechanism in the Bacillus subtilis yitJ S box/SAM-I riboswitch. The neutralizing capacity of these immune plasmas is relatively ...
Clinical heart failure continues to be defined for a long period as a scientific with symptoms and signals including shortness of breath, cyanosis, ascites, and edema. in preclinical research to exert helpful effects in pet models of serious LV dysfunction and appear to have the to make a direct effect in the scientific practice of heart-failure administration. 11, 1989C2010. Launch Clinical center failure is typically thought as a symptoms with particular symptoms and signals, including shortness of breathing, cyanosis, ascites, and edema. It could derive from abnormalities from the pericardium, myocardium, endocardium, or the fantastic vessels, however the majority of instances are connected with myocardial dysfunction. Coronary artery disease, hypertension, and dilated Mifepristone (Mifeprex) supplier cardiomyopathy will be the most significant causes under western culture. Heart failure is definitely a major general public health issue in america and all over the world. About 550,000 fresh ...
The morbidity, mortality and health care costs associated with congestive heart failure make prevention a more attractive public health strategy than treatment. Aggressive management of etiologic factors, including hypertension, coronary artery disease, valvular disease and excessive alcohol intake, can prevent the left ventricular remodeling and dysfunction that lead to heart failure. Early intervention with angiotensin converting enzyme inhibitors in patients with chronic left ventricular dysfunction can prevent, as well as treat, the syndrome. Several intervention strategies in patients with acute myocardial infarction can slow or prevent the left ventricular remodeling process that antedates congestive heart failure. The primary care physician must be alert to the need for aggressive intervention to reduce the burden of heart failure syndrome on the patient and on society.
Paper:Pericardial effusion and left ventricular dysfunction in patients with hepatic cirrhosis. Benha M. J. vol.11 No. 3 . , Author:Nabil Khattab , Tawheed Mowafy , Mohamed Salem, Ahmed Saleh, Sameh Bahgat, Osama Sanad, EL-Metwally Abdel Baset, and Ashraf Nassar. , Year:1994 , Faculty of Medicine ,Department of INTERNAL MEDICINE ,Benha University
Left Ventricular Dysfunction - Market Insights, Epidemiology and Market Forecast - 2025 is a market research report available at US $5750 for a Single User PDF License from RnR Market Research Reports Library.
Conclusion: Our findings indicate that myocardial damage in patients with diabetes affects diastolic function before systolic function.Even young patients with diabetics with normal systolic ventricular function have diastolic dysfunction, which serves as a marker of a diabetic cardiomyopathy. Diastolic impairment seems not to correlate with disease duration. HbA1c% can be a very good indicator of long term prognosis. Strong correlation exist between diastolic dysfunction and HbA1c%.. ...
TY - JOUR. T1 - Akute angiographie für alle reanimationspatienten bei aufnahme in die klinik. AU - Kern, Karl B. PY - 2012/8. Y1 - 2012/8. N2 - Any patient resuscitated from out-of-hospital cardiac arrest thought to have a cardiac etiology should have emergency coronary angiography upon arrival at the hospital. No current algorithm correctly identifies who has an acutely occluded coronary artery as their cardiac arrest trigger and who does not. However, 75% of those with ST elevation and 33% of those without ST elevation on their postresuscitation electrocardiogram have an acutely occluded coronary artery. To choose not to perform acute coronary angiography and reperfusion in all postresuscitation patients will leave at least one in three patients with significant myocardial loss, thus, resulting in chronic left ventricular dysfunction and heart failure.. AB - Any patient resuscitated from out-of-hospital cardiac arrest thought to have a cardiac etiology should have emergency coronary ...
The participants were randomly assigned to receive the usual primary care (control condition; n = 677) or screening with BNP testing (n = 697) and followed up until December 2011 (mean follow-up, 4.2 [SD, 1.2] years). Intervention-group participants, with BNP levels of 50 pg/mL Sirtinol clinical trial or higher, underwent. echocardiography and collaborative care between their primary care physician and specialist cardiovascular service. The primary end point was prevalence of asymptomatic systolic LV dysfunction, with or without newly diagnosed heart failure. Due to the slower than expected recruitment rates, the investigators extended the study period and redefined the primary endpoint to include significant LV diastolic dysfunction as determined by a ratio of mitral peak velocity. of early filling (E) to early diastolic mitral annular velocity (E) greater than 15.It is important to note that this change did not alter the validity of the study design. Secondary end points included emergency ...
Background/Aims: Left ventricular diastolic dysfunction (LVDD) is an early manifestation of cardiac dysfunction in patients with liver cirrhosis (LC). However, the effect of LVDD on survival has not been clarified, especially in decompensated LC.. Methods: We prospectively enrolled 70 patients with decompensated LC, including ascites or variceal bleeding, at Daejeon St. Marys Hospital from April 2013 to April 2015. The cardiac function of these patients was evaluated using 2D echocardiography with tissue Doppler imaging. The diagnosis of LVDD was based on the American Society of Echocardiography guidelines. The primary endpoint was overall survival.. Results: Forty-four patients (62.9%) had LVDD. During follow-up (22.3 months), 18 patients died (16 with LVDD and 2 without LVDD). The survival rate was significantly lower in patients with LVDD than in those without LVDD (31.1 months vs. 42.6 months, P=0.01). In a multivariate analysis, the Child-Pugh score and LVDD were independent predictors of ...
Diastolic dysfunction was found to be predictive of clinical heart failure, with five-year cumulative probabilities of 36.9% in those with diastolic dysfunction and 16.8% in those without (p , 0.001). In a multivariate analysis, the hazard ratio for developing heart failure was 1.61 [1.17-2.20; p = 0.003] after adjustment for various other demographic and echocardiographic parameters. Similar trends were seen for death: five-year cumulative probabilities of 30.8% in those with diastolic dysfunction and 12.1% in those without (p , 0.001) with a corresponding hazard ratio of 2.01 [1.32-3.06; p = 0.001] in multivariate analysis. The cumulative five-year probabilities of developing atrial fibrillation were higher in diastolic dysfunction (18.7% versus 8.8%; p , 0.001) but the association was absent after adjustment for other factors. The association with clinical heart failure was found to be independent of the effects of hypertension in a subgroup analysis ...
2010 (English)In: Journal of the American Society of Echocardiography, ISSN 0894-7317, E-ISSN 1097-6795, Vol. 23, no 2, 162-163 p.Article in journal (Other academic) Published ...
Assessing left ventricular global systolic function, left ventricular dysfunction, cardiomyopathy and cardiac decompensation on MedMastery
The LV and right ventricular (RV) diastolic function was evaluated in 65 patients with degree II arterial hypertension (AH) (WHO/IAH?, mean age 50.6±1.2 years) using Doppler echoCG at rest and in cold stress. The study demonstrated a possibility for asynchronous development of ventricular diastolic dysfunction with its prevalence of 14.7% for LV and 23.5% for RV. Disorders of both LV and RV diastolic function were revealed in 26.5% of patients. The cold test considerably more frequently induced impairment of RV than LV diastolic function. Both LV and RV diastolic dysfunction can be sufficiently well corrected with lisinopril, nebivolol and amlodipine ...
Linear regression models were first developed separately in women and men with LVEF as the dependent variable and independent variables that were significant (P,0.10) in univariate analyses (age, pulse pressure, diabetes, serum creatinine concentration, and uric acid level), as well as body mass index, race, and number of antihypertensive drugs. In women, lower LVEF (in percent) was associated (multiple R=0.20) independently with diabetes (B=−1.28, β=−0.063, P=0.03) and higher body mass index (B=−0.08, β=−0.075, P=0.01). When self-reported myocardial infarction and CHF were also considered, lower LVEF was independently associated (R=0.23) with heart attack (B=−5.7, β=−0.144, P,0.001), CHF (B=−5.3, β=−0.109, P=0.001), and body mass index (B=−0.8, β=−0.073, P=0.038). In men, lower EF was associated (R=0.19) with older age (B=−0.08, β=−0.086, P=0.043), higher uric acid (B=−0.5, β=−0.085, P=0.040), and ACE inhibitor use. When prevalent disease variables were also ...
Systolic alterations in left ventricular (LV) myocardial function have been reported previously in patients with diastolic dysfunction (DD). Recent advances in real-time three-dimensional echocardiography (3DE) enable the measurement of a set of parameters previously difficult to obtain with standard two-dimensional echocardiography (2DE). The aim of this study was to evaluate global 3DE LV contraction in patients with and without DD who had normal ejection fraction (EF). ...
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Seven patients developed clinical features simulating myocardial ischemia less than 72 hours after 12 of 13 separate intravenous 5-fluorouracil administrations; 9 episodes were associated with chest pain, 3 with hypotension, 3 with ventricular tachyc
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Symptomatic severe MR is a Class I indication for surgery in both the ESC and ACC/AHA guidelines (1,2); therefore, demonstration of symptoms during exercise VSE in self-declared asymptomatic patients with severe MR is a robust surgical indication. The ESC guidelines (1) recognize exertion-induced SPAP increase to ,60 mm Hg as a Class IIb indication for surgery in asymptomatic severe MR, in cases of high likelihood of durable repair and low surgical risk. No recommendation based on an exercise-induced SPAP increase exists in the current ACC/AHA guidelines (2). There is evidence that the lack of LV contractile reserve during VSE predicts a drop in LVEF at follow-up, which is associated with functional capacity deterioration in conservatively treated patients (26,27) and post-operative LV systolic dysfunction and lower event-free survival in surgically treated patients (28). LV systolic dysfunction is a Class I surgical indication in asymptomatic patients with severe MR; although VSE is ...
OBJECTIVE Considering that global left ventricular systolic radial strain is a sensitive technique for the early detection of left ventricular dysfunction due to antineoplastics and the analysis of segmental myocardial contractility, we evaluated this technique for early detection of trastuzumab-related cardiotoxicity by comparing it with cardiac structural damage. METHODS Groups of six mice were injected with trastuzumab or doxorubicin, used either as single agents or in combination. Cardiac function was evaluated by transthoracic echocardiography measurements before and after treatment for 2 or 7 days, by using a Vevo 2100 high-resolution imaging system. After echocardiography, mice were euthanized, and hearts were processed for histological evaluations, such as cardiac fibrosis, apoptosis, capillary density, and inflammatory response. RESULTS Trastuzumab-related cardiotoxicity was detected early by 2D strain imaging. Radial strain was reduced after 2 days in mice treated with trastuzumab alone
All patients with heart failure should have an echocardiogram to establish a diagnosis, both to aid treatment as well as for prognostic reasons. An audit of 100 case notes of patients admitted with acute left ventricular failure over a 12-month period found that 26 patients had not had an echocardiogram. Of the 74 who did have an echocardiogram 68 patients had reduced systolic function (mean ejection fraction 42%). Almost all (93%) were commenced on an angiotension-converting enzyme (ACE) inhibitor. Those who did not receive an ACE inhibitor had no contraindications to these drugs. Seventeen patients had a confirmed myocardial infarction. Of these, 11 had an echocardiogram and 10 were discharged home on an ACE inhibitor. Despite appropriate indications some patients are deprived of echocardiography as well as the benefits of ACE inhibitors.. ...
BACKGROUND: We sought to investigate whether the paucity of anginal symptoms in patients with ischemic cardiomyopathy reflects a reduction in the severity of stress-induced myocardial ischemia. METHODS AND RESULTS: We selected 38 patients with coronary artery disease and severe left ventricular dysfunction (ejection fraction [EF ...
Left ventricular diastolic dysfunction. *Valvular heart disease. *Congenital/acquired left heart inflow/outflow tract ... If it is caused by left heart disease, the treatment is to optimize left ventricular function by the use of medication or to ... The phonocardiograms (fourth left interspace and cardiac apex) show a murmur of tricuspid insufficiency and ventricular and ... with systolic ventricular pressures that are lower than those that the left ventricle normally encounters. As such, the right ...
... in HIV-infected children reduces left ventricular dysfunction, increases left ventricular wall thickness, and reduces peak left ... In addition, patients with echocardiographic evidence of left ventricular dysfunction had a higher chance of having cardiac ... Many patients with HIV have nutritional deficiencies which have been linked to left ventricular dysfunction. HIV-infected ... Myocarditis and cardiotropic viral infection associated with severe left ventricular dysfunction in late-stage infection with ...
Risk of severe CHF or left ventricular dysfunction, especially in patients with comorbidities ...
... after left ventricular dysfunction) ... left ventricular function, and cardiac output and tissue ... sexual dysfunction, erectile dysfunction and/or alteration of glucose and lipid metabolism. Mixed α1/β-antagonist therapy is ... "Vanderbilt Autonomic Dysfunction Center - Propranolol (Beta Blocker) - Vanderbilt Health Nashville, TN". ww2.mc.vanderbilt.edu ... "Vanderbilt Autonomic Dysfunction Center - Propranolol (Beta Blocker) - Vanderbilt Health Nashville, TN". ww2.mc.vanderbilt.edu ...
Dyke D, Koelling T (2008). "Heart failure due to left ventricular systolic dysfunction". In Eagle KA, Baliga RR (eds.). ... It is being studied for a potential role in the treatment of left ventricular systolic heart failure. Systolic heart failure ... Thus, the overall clinical result of omecamtiv mecarbil is an increase in left ventricular systolic ejection time and ejection ... leading to left ventricular hypertrophy, another characteristic of chronic heart failure. Current inotropic therapies work by ...
Left Ventricular end-systolic Dimension; see Ventricle (heart)#Dimensions Left ventricular systolic dysfunction; see Heart ... failure#Systolic dysfunction Ligonier Valley School District in Westmoreland County, Pennsylvania This disambiguation page ...
Heart failure (left ventricular systolic dysfunction). *Kidney complications of diabetes mellitus (diabetic nephropathy) ... It contributes to ventricular remodeling and ventricular hypertrophy of the heart through stimulation of the proto-oncogenes c- ... Patients with heart failure may benefit from the combination in terms of reducing morbidity and ventricular remodeling.[61][62] ... This leads to cardiac dysfunction and neuromuscular consequences, such as muscle weakness, paresthesia, nausea, diarrhea, and ...
August 1993). "Activation of neurohumoral systems in postinfarction left ventricular dysfunction". Journal of the American ...
Cite journal requires ,journal= (help) Pollak, A; Falk, R H (1993-08-01). "Left ventricular systolic dysfunction precipitated ... from restrictive cardiomyopathy will usually eventually have to be treated by cardiac transplantation or left ventricular ... Patients will demonstrate normal systolic function, diastolic dysfunction, and a restrictive filling pattern. 2-dimensional and ... In time, restrictive cardiomyopathy patients develop diastolic dysfunction and eventually heart failure.[citation needed] ...
... leaving an abnormally elevated volume of blood in the left ventricle. In diastolic dysfunction, the end-diastolic ventricular ... early-to-atrial left ventricular filling ratio), the E (early left ventricular filling) deceleration time, and the isovolumic ... ventricular end-diastolic pressure and volumes increase. This is transmitted to the atrium. On the left side of the heart, the ... pulmonary edema in left heart failure, peripheral edema in right heart failure).[citation needed] Diastolic dysfunction can be ...
Knorr, Andreas M. (1995). "Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?". The American Journal ...
CXCL9, -10, -11 have proven to be valid biomarkers for the development of heart failure and left ventricular dysfunction, ... "Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study". ...
"Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice". American Journal of Physiology. Heart and ...
Cardiovascular system damage can include myocardial ischemia/infarction, acute left ventricular dysfunction, acute pulmonary ... As the left ventricle becomes unable to compensate for an acute rise in systemic vascular resistance, left ventricular failure ... with hypertensive crises often have chest pain as a result of this mismatch and may suffer from left ventricular dysfunction. ... and subsequent dysfunction. After an acute event, this endothelial dysfunction has persisted for years[9]. ...
... leaving an abnormally elevated volume of blood in the left ventricle. In diastolic dysfunction, the end-diastolic ventricular ... early-to-atrial left ventricular filling ratio), the E (early left ventricular filling) deceleration time, and the isovolumic ... to left ventricular dysfunction and heart failure with normal ejection fraction depending on whether the ability of the left ... This type is also known as heart failure due to left ventricular systolic dysfunction or systolic heart failure. This type of ...
Gatasko, Gavin I; Senior, Roxy; Lahiri, Avijit (2002). "A simple model to predict left ventricular systolic dysfunction in a ... "What is the most cost-effective strategy to screen for left ventricular systolic dysfunction: Natriuretic peptides, the ...
Cardiac involvement usually presents with evidence of left ventricular dysfunction and ECG changes; it occurs more often in ... Dysfunction of the kidney and liver are also suggested to promote this disorder in response to other drugs due to the ... or other organ dysfunctions. DRESS syndrome is one of several terms that have been used to describe a severe idiosyncratic ... and motor dysfunction due to meningitis or encephalitis. Rare manifestations of the disorder include inflammation of the ...
The bronchoconstriction is also caused by left ventricular dysfunction, caused by the SRTXs. Left ventricular relaxation is ... This peribronchial edema is likely caused by impairment of left ventricular relaxation, elevating microvascular hydrostatic ...
Myocardial imaging usually demonstrates left ventricular dilation, severe ventricular dysfunction, and multiple infarctions. ... Some argue that only left main- or proximal-left anterior descending artery disease is relevant to the diagnostic criteria for ... "Results of Coronary Artery Bypass Grafting by a Single Surgeon Patients With Left Ventricular Ejection Fractions ≤30%". The ... A 2004 study showed the patients in that study who underwent ventricular restoration as well as a coronary artery bypass ...
"Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias". Heart ...
Worse outcomes have been seen when echocardiography shows left ventricular wall thickness, poor systolic function and severe ... Prognosis of cardiac amyloidosis is correlated to the extent of the cardiac dysfunction. Usually the prognosis is not good and ... Right heart catheterization is the test used to test for elevated diastolic ventricular pressures. This test is more invasive ... showing low voltage and conduction abnormalities like atrioventricular block or sinus node dysfunction.[5] ...
The ventricular septal shift to the left causes a left ventricular diastolic dysfunction, which further increases pulmonary ... By convention cardiogenic refers to left ventricular causes. Cardiogenic[edit]. *Congestive heart failure which is due to the ... Classically it is cardiogenic (left ventricular) but fluid may also accumulate due to damage to the lung. This damage may be ... There is also a significant increase in left ventricular afterload, which causes a decreased cardiac output. The increase in ...
A patient is said to have diastolic dysfunction if he has signs and symptoms of heart failure but the left ventricular ejection ... Left ventricular filling is dependent upon ventricular relaxation and compliance, mitral valve area, atrio-ventricular gradient ... decreased left ventricular distensibility) can occur both in those with normal and those with decreased left ventricular ... When the left ventricular diastolic pressure is elevated, venous pressure in lungs must also become elevated too: left ...
... is used to treat hypertension, symptomatic heart failure, and asymptomatic left ventricular dysfunction. It has been ...
Diastolic dysfunction is an early consequence of hypertension-related heart disease and is exacerbated by left ventricular ... May 2007). "[Left ventricular diastolic function and dysfunction: a single cardiac target for various systemic diseases]". ... Individuals with left ventricular hypertrophy are at increased risk for, stroke, CHF, and sudden death. Aggressive control of ... left ventricular hypertrophy are seen in 25% of the hypertensive patients and can easily be diagnosed by using echocardiography ...
Cardiomyopathy and left ventricular diastolic dysfunction caused by fibrosis or scarring of cardiac tissues. This also ...
Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN ...
Cardiac chamber catheterization assists in assessing the severity of regurgitation and any left ventricular dysfunction. The ... 0.3 cm2 Increased left ventricular size Chest X-ray can assist in making the diagnosis, showing left ventricular hypertrophy ... This relaxation of the left ventricle (early ventricular diastole) causes a fall in its pressure. When the pressure in the left ... and the degree of left ventricular dysfunction. Surgical treatment in asymptomatic patients has been recommended if the ...
... left ventricular dysfunction, or congestive heart failure.[37] Another skin condition, found in Europe but not in North America ... on leaves or grasses close to the ground with forelegs outstretched; when a host brushes against its limbs, the tick rapidly ... while echocardiography may show myocardial dysfunction.[37] Biopsy and confirmation of Borrelia cells in myocardial tissue may ... Dogs may also experience chronic joint disease if the disease is left untreated. However, the majority of cases of Lyme disease ...
IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and ... which leaves potential for off-target epigenetic marks causing unwanted epigenetic modifications. ... These diseases are characterized by chronic and progressive neuronal dysfunction, sometimes leading to behavioral abnormalities ...
... allowing blood to exit the left ventricle into the aorta. When ventricular systole ends, pressure in the left ventricle rapidly ... Valvular heart disease is a general term referring to dysfunction of the valves, and is primarily in two forms, either ... Left heart. *(pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus ... displaystyle A(x,t)=A_{0}\left(1-[1-{\Lambda }(t)]{x \over {L}}\right)^{2}}. ∫. 0. L. p. (. x. ,. t. ). ∂. A. ∂. x. d. x. =. [ ...
"Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice". American Journal of Physiology. Heart and ...
There is no sensory neuropathy or autonomic or visceral dysfunction at presentation.[medical citation needed] ... Arrhythmogenic right ventricular dysplasia 9. *centrosome: PCNT (Microcephalic osteodysplastic primordial dwarfism type II) ... alpha sarcoglycan Left side-normal muscle /right side LGMD2. There is a variety of research under way targeted at various forms ...
Diastolic dysfunction is also associated with AF, which increases left atrial pressure, left atrial volume, size, and left ... left ventricular size and function, peak right ventricular pressure (pulmonary hypertension), presence of left atrial thrombus ... Lower heart rates may be recommended in those with left ventricular hypertrophy or reduced left ventricular function.[110] Rate ... presence of left ventricular hypertrophy and pericardial disease.[21] Significant enlargement of both the left and right atria ...
Severe pain (including labour pain); cough due to terminal lung cancer; angina; left ventricular failure.. As per codeine. ... Sedation, anticholinergic effects, weight gain, orthostatic hypotension, sinus tachycardia, sexual dysfunction, tremor, ... As per other opioids, plus ventricular rhythm disorders. Levomethadone. Comes in hydrochloride salt form; soluble in water and ... Anticholinergic effects, GI effects, yawning, sweating, dizziness, weakness, sexual dysfunction, somnolence, insomnia, headache ...
... slow left ventricular relaxation time, right tricuspid valve regurgitation), preferential distribution of blood flow to the ... Coagulation dysfunction is not a cause of EIPH, and anticoagulatory agents, including carbazochrome salicylate, aspirin, ... The staining is usually most intense in the dorso-caudal region of the left and right diaphragmatic lobes which often ... Horses that undergo surgical correction for upper airway dysfunction are rested, and are under environmentally controlled ...
... allowing blood to exit the left ventricle into the aorta. When ventricular systole ends, pressure in the left ventricle rapidly ... Valvular heart disease is a general term referring to dysfunction of the valves, and is primarily in two forms, either ... displaystyle A(x,t)=A_{0}\left(1-[1-{\Lambda }(t)]{x \over {L}}\right)^{2}}. ∫. 0. L. p. (. x. ,. t. ). ∂. A. ∂. x. d. x. =. [ ... It is on the left side of the heart and allows the blood to flow from the left atrium into the left ventricle. ...
Left: EEG traces (horizontal - time in seconds; vertical - amplitudes, scale 100 μV). Right: power spectra of shown signals ( ... Note that there are types of activity that are statistically uncommon, but not associated with dysfunction or disease. These ... Left: EEG traces (horizontal - time in seconds; vertical - amplitudes, scale 100 μV). Right: power spectra of shown signals ( ... "EEG evidence for mirror neuron dysfunction in autism spectrum disorders". Cognitive Brain Research. 24 (2): 190-8. doi:10.1016/ ...
... with sustained sinus tachycardia reflects a larger infarct that are more anterior with prominent left ventricular dysfunction, ... If the heart rate is too high, cardiac output may fall due to the markedly reduced ventricular filling time. Rapid rates, ...
Prevalence Of Diastolic Dysfunction In Patients With Hypertension Referred For Echocardiographic Assessment of Left Ventricular ... Wright and Meyerdirk left the University to form Physionic Engineering Inc., which launched the first commercial hand-held ... Ultrasound is an excellent method for the study of the penis, such as indicated in trauma, priapism, erectile dysfunction or ... It is currently believed that the risk of leaving these conditions undiagnosed is greater than the small risk, if any, ...
Keating G, Plosker G (2004). "Eplerenone: a review of its use in left ventricular systolic dysfunction and heart failure after ... 2001). "Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the ... 1992). "Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial ... 2006). "Epidemiology of heart failure and left ventricular systolic dysfunction after acute myocardial infarction: prevalence, ...
2003). «Effects of isolated obesity on systolic and diastolic left ventricular function». Heart. 89 (10): 1152-6. PMC 1767886 ... 2000). «Anorectal dysfunction in constipated women with anorexia nervosa». Mayo Clinic Proceedings. 75 (10): 1015-9. PMID ... Neuroendocrine control of hypothalamic dysfunction». The International Journal of Eating Disorders. 16 (1): 53-60. PMID 7920581 ...
Mild or remittent disease may, sometimes, be safely left untreated. If required, nonsteroidal anti-inflammatory drugs and ... Other common neuropsychiatric manifestations of SLE include cognitive dysfunction, mood disorder, cerebrovascular disease,[33] ... absence of a space-occupying lesion or ventricular enlargement, and normal cerebrospinal fluid chemical and hematological ... due to mitochondrial dysfunction, oxidative stress, and depletion of ATP.[64] ...
... the swelling of lung tissue due to left ventricular failure an inability of the left ventricle of the heart to adequately pump ... caused by brain swelling and dysfunction, and characterized by headaches and an altered level of consciousness (confusion or ...
During the check-up moderate azotemia, mild erythronormoblastic anemia, proteinuria and lowering of left vascular ejection ... erectile dysfunction as an early sign of general atherosclerosis (ASVD); occurrence of erosive-ulcerative lesions in the mucous ... complex ventricular arrhythmias, and silent myocardial ischemia and incidence of new coronary events in older persons with ...
... for improving visualization of the left ventricular chamber of the heart, the delineation of the endocardial borders in ... In vitro assessment of endothelial dysfunction and multi-targeting to ICAM-1 and sialyl Lewis(x)". Biotechnol. Bioeng. 92: 780- ... The test would be positive for an abnormal communication if the bubbles are seen passing into the left side of the heart. ( ...
... influence of left ventricular systolic dysfunction and heart rate-modulating drugs". Heart Rhythm: The Official Journal of the ... "Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction ( ... Salerno DM, Zanetti J (1991). "Seismocardiography for monitoring changes in left ventricular function during ischemia". Chest. ... In obstetrics, heart rate can be measured by ultrasonography, such as in this embryo (at bottom left in the sac) of 6 weeks ...
Ventricular hypertrophy, the thickening of the ventricular walls, is generally beneficial and healthy if it occurs in response ... and left superior temporal lobe) and white matter (anterior third of corpus callosum) [88]. In addition, Colcombe and ... which promote neuronal dysfunction and death (Hardy and Selkoe, 2002; Karran et al., 2011). Evidence in transgenic mouse models ... high cardiac output has been shown to cause enlargement of the left and right ventricle volumes, increased ventricle wall ...
... and its cell body resides in the ventricular zone, adjacent to the developing ventricular system. Neural stem cells are ... Stem cells differentiate when they leave that niche or no longer receive those signals. Studies in Drosophila germarium have ... This accumulation is considered to be responsible, at least in part, for increasing stem cell dysfunction with aging (see DNA ...
L.V. Left ventricle.. P.A. Pulmonary artery.. R.A. Right atrium.. R.V. Right ventricle.. V.S. Ventricular septum. ... Papillary muscle rupture can be caused by a myocardial infarct, and dysfunction can be caused by ischemia. Both complications ... Left heart. *(pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus ... The papillary muscles of both the right and left ventricles begin to contract shortly before ventricular systole and maintain ...
... dan bersama IL-6 dapat menjadi faktor pemicu gagal jantung atau Left ventricular diastolic dysfunction.[4] Pada hepatosit, TNF- ... "Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders ...
... or a left ventricular assist device (LVAD). ... Insulin-dependent diabetes with severe organ dysfunction. * ... Notice how the back of the patient's left atrium and great vessels are left in place. ... left ventricle to aorta Rastelli procedure. right ventricle to pulmonary artery Sano shunt. compound procedures. for ... Ventricular reduction. Alcohol septal ablation. Conduction system. Maze procedure Cox maze and minimaze. Catheter ablation ...
... while unmyelinated pain nerves are left intact. Overuse of an affected hand or limb can activate symptoms including numbness, ... "Neurological dysfunction and axonal degeneration in Charcot-Marie-Tooth disease type 1A". Brain. 123 (7): 1516-27. doi:10.1093 ... Arrhythmogenic right ventricular dysplasia 9. *centrosome: PCNT (Microcephalic osteodysplastic primordial dwarfism type II) ...
Mitochondrial dysfunction as a cause of optic neuropathies. Progress in Retinal and Eye Research. 23 (2004) 53-89. Oostra, R.J ... This initially presents with problems with colors (dyschromatopsia) and can leave central visual deficits. If vision loss ... Amiodarone is an antiarrhythmic medication commonly used for abnormal heart rhythms (atrial or ventricular tachyarrythmias). ... Rarely, amiodarone, interferon-alpha, and erectile dysfunction drugs have been associated with this disease. Posterior ischemic ...
... dysfunction are the most concerning and serious cardiovascular complications of cancer therapies and cause an increase in ... Cancer therapy-induced left ventricular dysfunction: interventions and prognosis. J Card Fail. 2014;20:155-8.CrossRefGoogle ... Heart failure Left ventricular dysfunction Cardiotoxicity Echocardiography Cardiac magnetic resonance Biomarkers ... Novo G., Nugara C., Lancellotti P. (2019) Heart Failure and Left Ventricular Dysfunction. In: Russo A., Novo G., Lancellotti P ...
Reviews and ratings for Enalapril when used in the treatment of left ventricular dysfunction. Share your experience with this ... Learn more about Left Ventricular Dysfunction. Symptom checker. *Chest Pain. Mayo Clinic Reference. *Left ventricular ... User Reviews for Enalapril to treat Left Ventricular Dysfunction. Also known as: Vasotec, Epaned ... His ventricular function has not deteriorated since starting enalapril 9 years ago and his cardiologist tells him to take this ...
Reversible left ventricular systolic dysfunction: reversibility of coronary microvascular abnormality. Jpn Heart J. 2001; 42: ... The clinical impact of reversal of the left ventricular dysfunction seen with brain death4,5 may hold great promise for ... Tako-Tsubo-Like Left Ventricular Dysfunction. Junya Ako, Yasuhiro Honda, Peter J. Fitzgerald ... Reversible left ventricular dysfunction associated with raised troponin I after subarachnoid haemorrhage does not preclude ...
Reviews and ratings for lotensin when used in the treatment of left ventricular dysfunction. Share your experience with this ... Learn more about Left Ventricular Dysfunction. Symptom checker. *Chest Pain. Mayo Clinic Reference. *Left ventricular ... Left Ventricular Dysfunction carvedilol, metoprolol, Coreg, benazepril, valsartan, More.... Heart Failure amlodipine, ... Reviews for Lotensin to treat Left Ventricular Dysfunction. No reviews have yet been submitted. Be the first to review this ...
This topic contains 8 study abstracts on Left Ventricular Dysfunction indicating that the following substances may be helpful: ... Diseases : Left Ventricular Dysfunction, Left Ventricular Hypertrophy. Pharmacological Actions : Cardiovascular Agents, Matrix ... repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. ... Diseases : Left Ventricular Dysfunction, Myocardial Infarction, Stem Cell Transplant. Therapeutic Actions : Stem Cell ...
... Line Lisbeth Olesen1 and Thomas Vauvert F. ... "Upregulation of Soluble HLA-G in Chronic Left Ventricular Systolic Dysfunction," Journal of Immunology Research, vol. 2016, ...
Measurement of BNP could be a cost-effective method of screening for left-ventricular systolic dysfunction in the general ... We took a left-ventricular ejection fraction of 30% or less to show left-ventricular systolic dysfunction. NT-ANP and BNP were ... Biochemical detection of left-ventricular systolic dysfunction Lancet. 1998 Jan 3;351(9095):9-13. doi: 10.1016/s0140-6736(97) ... Background: In previous studies on the use of natriuretic peptides to detect left-ventricular systolic dysfunction, a higher ...
... Alberto Palazzuoli, Matteo Beltrami, ... "The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction," The Scientific World Journal, vol. 2013, ...
The value and cost-effectiveness of screening for left ventricular (LV) dysfunction remains unclear, particularly since ... specific, evidence-based treatments are not available for the majority of patients with preserved systolic dysfunction, reports ... Home Health Screening for left ventricular dysfunction may have less value than thought ... Screening for left ventricular dysfunction may have less value than thought. June 11, 2009. ...
An echocardiogram (below left) showed severe left ventricular impairment (ejection fraction , 20%). ...
Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults. The HyperGEN Study. Richard B. Devereux, ... Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults. Richard B. Devereux, Jonathan N. Bella, ... Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults. Richard B. Devereux, Jonathan N. Bella, ... had mild ventricular dysfunction (ejection fraction 41% to 54%), and 4% had severe ventricular dysfunction (ejection fraction ≤ ...
Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults. The HyperGEN Study. Richard B. Devereux, ... Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults. Richard B. Devereux, Jonathan N. Bella, ... Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults. Richard B. Devereux, Jonathan N. Bella, ...
Deteriorating glucose tolerance status is associated with left ventricular dysfunction-the Hoorn Study. Neth J Med 2008;66:110- ... Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction. An 8-year follow ... Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction ... Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction ...
Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction. An 8-year follow ... Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction ... Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction ... Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction ...
Thirty to fifty percent of patients presenting with signs and symptoms of heart failure have a normal left ventricular (LV) ... Left ventricular diastolic dysfunction and diastolic heart failure Annu Rev Med. 2004;55:373-94. doi: 10.1146/annurev.med. ... Ventricular Dysfunction, Left / diagnosis* * Ventricular Dysfunction, Left / physiopathology* * Ventricular Dysfunction, Left ... Thirty to fifty percent of patients presenting with signs and symptoms of heart failure have a normal left ventricular (LV) ...
"Ventricular Dysfunction, Left" by people in Harvard Catalyst Profiles by year, and whether "Ventricular Dysfunction, Left" was ... "Ventricular Dysfunction, Left" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Ventricular Dysfunction, Left*Ventricular Dysfunction, Left. *Left Ventricular Dysfunction. *Dysfunction, Left Ventricular ... Below are the most recent publications written about "Ventricular Dysfunction, Left" by people in Profiles. ...
Steps Forward in the Assessment of Myocardial Viability in Left Ventricular Dysfunction. James E. Udelson ... Prognosis of patients with left ventricular dysfunction, with and without viable myocardium after myocardial infarction: ... Steps Forward in the Assessment of Myocardial Viability in Left Ventricular Dysfunction ... Steps Forward in the Assessment of Myocardial Viability in Left Ventricular Dysfunction ...
... after exercise can identify early left ventricular dysfunction in asymptomatic patients with moderate-severe aortic stenosis. ... in peak systolic mitral annular velocity after treadmill exercise is a marker of early left ventricular systolic dysfunction. ... Objective: To determine whether longitudinal left ventricular systolic function measured by Doppler tissue imaging (DTI) ... and left ventricular ejection fraction ,50% and 15 aged-matched normal controls. ...
... left ventricular dysfunction and effect of coronary vaso.... 7889549 - Directional atherectomy of left main stenoses.. 2289409 ... 3 with ventricular tachycardia and 1 with cardiogenic shock. Left ventricular dysfunction was demonstrated by echocardiography ... Therapy with 5-fluorouracil is associated with cardiotoxicity simulating myocardial ischemia with left ventricular dysfunction ... 8848389 - A critical period of ventricular fibrillation more susceptible to defibrillation: real-.... 791649 - Heart failure in ...
Biochemical detection of left-ventricular systolic dysfunction. Lancet 1998; 351: 9-13. ... The prevalence (or prior probability) of left ventricular systolic dysfunction in this study was 32%; this is consistent with ... Likelihood ratios for screening tests for left ventricular systolic dysfunction. Any combination of tests is defined as being ... Concentrations of the peptide were raised in the 40 patients with left ventricular systolic dysfunction (median concentration ...
Ventricular Dysfunction, Left / etiology, physiopathology, ultrasonography*. Ventricular Function, Left*. Young Adult. beta- ... 17437737 - Effect of left ventricular scar size, location, and transmurality on left ventricular r.... 24513477 - Functional ... 20374947 - Coronary reserve impairment prevents the improvement of left ventricular dysfunction an.... 22461067 - Cryoinjury as ... The aim of this study is to evaluate left ventricular (LV) functions by tissue velocity imaging (TVI) and strain imaging (SI) ...
PubMed journal article Contribution of left ventricular diastolic dysfunction to heart failure regardless of ejection fractio ... In HF with an ejection fraction ,/=0.40, systolic dysfunction and left ventricular dilation accompany diastolic dysfunction. SN ... In HF with an ejection fraction ,/=0.40, systolic dysfunction and left ventricular dilation accompany diastolic dysfunction. ... Contribution of Left Ventricular Diastolic Dysfunction to Heart Failure Regardless of Ejection Fraction. Am J Cardiol. 2005 Mar ...
0.45 and their predictive value for left ventricular systolic dysfunction.. Results: 15 patients (12%) had left ventricular ... The prevalence of left ventricular systolic dysfunction was 12%(nine men and six women). Table 2 describes these 15 patients. ... Symptomatic and asymptomatic left-ventricular systolic dysfunction in an urban population. Lancet 1997;350: 829-833. ... Predictive markers of left ventricular systolic dysfunction (ejection fraction 0.45) were identified by theχ2 test with ...
Left atrial dysfunction relates to symptom onset in patients with heart failure and preserved left ventricular ejection ... Left ventricular strain rate showed no differences between non-HF and HFPEF groups, but both groups showed differences with the ... Left atrial (LA) function has been related to HF symptoms. Our purpose is to analyse LA function in outpatients with new onset ... In outpatients with new-onset symptoms of HF, LA dysfunction was observed. It might be the initial mechanism in the development ...
Ventricular Dysfunction, Left/complications. *Ventricular Dysfunction, Left/drug therapy*. *Ventricular Dysfunction, Left/ ... Long-term effects of carvedilol in idiopathic dilated cardiomyopathy with persistent left ventricular dysfunction despite ... who are poor responders in terms of left ventricular (LV) function and exercise tolerance to chronic treatment with the ... 1+/-2%, p = 0.045), a reduction in ventricular ectopic beats (-12+/-9 vs. +62+/-50 n/h, p = 0.05) and couplets (-0.5+/-0.4 vs ...
Pre-existing left ventricular systolic dysfunction (left ventricular ejection fraction , 50%). *Pre-existing atrial ... Left ventricular dysfunction [ Time Frame: At the time of screening ]. Left ventricular systolic function ... Opportunistic Screening for Asymptomatic Left Ventricular Dysfunction in Coronavirus Disease 2019 (COVID19) Survivors. The ... Opportunistic Screening for Asymptomatic Left Ventricular Dysfunction in COVID-19 Survivors. Estimated Study Start Date :. ...
Keywords: sex differences, left ventricular diastolic dysfunction, hypertension ... Little is known about the sex-specific differences in left ventricular (LV) diastolic dysfunction (DD) predictors. We ... Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension Joanna Jaroch,1 Olga Vriz,2 ... Background: Little is known about the sex-specific differences in left ventricular (LV) diastolic dysfunction (DD) predictors. ...
... in patients with left ventricular dysfunction after myocardial infarctio were found in PRIME PubMed. Download Prime PubMed App ... Ventricular Dysfunction, Left. Pub Type(s). Clinical Trial. Comparative Study. Journal Article. Multicenter Study. Randomized ... Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl ... Eplerenone, a Selective Aldosterone Blocker, in Patients With Left Ventricular Dysfunction After Myocardial Infarction. N Engl ...
Myocardial oxygen consumption in aortic valve disease with and without left ventricular dysfunction. ... Myocardial oxygen consumption in aortic valve disease with and without left ventricular dysfunction. ... Myocardial oxygen consumption in aortic valve disease with and without left ventricular dysfunction. ...
We investigated whether left ventricular diastolic dysfunction is associated with embolic burden in patients with ischem ic ... Background】Left ventricular diastolic dysfunction lead to left atrial stasis and thus increases a risk of left atrial appendage ... Background】Left ventricular diastolic dysfunction lead to left atrial stasis and thus increases a risk of left atrial appendage ... Left ventricular diastolic dysfunction and arterial occlusion in ischemic stroke related to atrial fibrillation. *. ...
  • The first is to reverse the consequences of diastolic dysfunction (e.g., venous congestion), and the second is to eliminate or reduce the factors responsible for diastolic dysfunction (e.g., myocardial hypertrophy, fibrosis, and ischemia). (nih.gov)
  • Ischaemia was diagnosed if Q waves, bundle branch block, T wave inversions, or left ventricular hypertrophy were present on an electrocardiogram. (bmj.com)
  • 17 (13%) patients had left ventricular hypertrophy. (ersjournals.com)
  • A multivariate analysis showed that clinic systolic blood pressure and mean nocturnal oxygen saturation were independently associated with left ventricular hypertrophy. (ersjournals.com)
  • LV hypertrophy (LVH) often seems to be associated with this LV diastolic dysfunction 15 . (ersjournals.com)
  • From a hemodynamic standpoint, AS increases LV afterload, and the natural response of the LV to the increased wall stress due to pressure overload is concentric remodeling, increase in LV mass, and development of left ventricular hypertrophy (LVH), which maintains wall stress and cardiac output. (onlinejacc.org)
  • The goal of this study was to examine the association of serum γ-glutamyltransferase (GGT) levels with left ventricular (LV) diastolic dysfunction and LV hypertrophy.Methods and Results:A cross-sectional study of 79,459 Korean men and women who underwent an echocardiography as part of a comprehensive health examination between March 2011 and December 2014. (physiciansweekly.com)
  • The presence of LV diastolic dysfunction and LV hypertrophy was determined using echocardiography. (physiciansweekly.com)
  • Both LV diastolic dysfunction and LV hypertrophy were associated with higher levels of serum GGT. (physiciansweekly.com)
  • This study demonstrated a positive association between serum GGT levels and LV diastolic dysfunction and LV hypertrophy in a large cohort of middle-aged men and women independent of potential confounders. (physiciansweekly.com)
  • Patients were divided into 2 groups: group composed of 46 patients with type I DM and left ventricular hypertrophy (LVH+ve group) compared to another group, composed of 89 patients with type I DM but had a normal left ventricular echocardiographic parameters (LVH -ve group). (scialert.net)
  • Echocardiographic follow-up was done thoroughly again for patients who had left ventricular hypertrophy (LVH) after two years. (scialert.net)
  • Patients with ESRD are prone to hypertension and left ventricular hypertrophy (LVH), which is a physiological response to pressure and volume overload. (biomedcentral.com)
  • This causes peripheral edema (blood pooling), which the sympathetic nervous system tries to correct by overstimulating the cardiac myocytes, leading to left ventricular hypertrophy, another characteristic of chronic heart failure. (wikipedia.org)
  • Temporal changes in left ventricular systolic function in heart donors: results of serial echocardiography. (ahajournals.org)
  • In the study,1012 primary care patients with hypertension and/or diabetes without signs or symptoms of heart failure were screened for asymptomatic left ventricular dysfunction (ALVD), using measurements of NT-pro-BNP and echocardiography. (scienceblog.com)
  • The full study is "The Role of N-Terminal PRO-Brain Natriuretic Peptide and Echocardiography for Screening Asymptomatic Left Ventricular Dysfunction in a Population at High Risk for Heart Failure: The PROBE-HF Study" by Irene Betti, Gabriele Castelli, Alessandro Barchielli, Cinzia Beligni, Vittorio Boscherini, Leonardo De Luca, Gianni Messeri, Mihai Gheorghiade, Alan Maisel, and Alfredo Zuppiroli. (scienceblog.com)
  • Left ventricular dysfunction was demonstrated by echocardiography in 5 separate episodes, 2 with interval improvement upon repeat echocardiograms. (biomedsearch.com)
  • To assess the probability of left ventricular systolic dysfunction without echocardiography in patients from general practice. (bmj.com)
  • Cross sectional study using multivariate regression models to examine the relation between clinical variables and left ventricular systolic dysfunction as determined by echocardiography. (bmj.com)
  • 1 - 5 About 3% of the adult population have systolic dysfunction, 6 - 8 but half of them are asymptomatic and can be identified only by objective methods, usually echocardiography. (bmj.com)
  • The purpose of the study was to examine how primary care doctors might identify patients at increased risk of systolic dysfunction in order to decide who to refer for echocardiography. (bmj.com)
  • Conventional echocardiography predictors of poor outcome, such as left ventricular (LV) ejection fraction (EF) and restrictive filling pattern have recently been supplemented by tissue Doppler imaging (TDI). (thefreelibrary.com)
  • In patients with heart failure (HF) symptoms, echocardiography often reveals a low left ventricular ejection fraction (LVEF). (thefreelibrary.com)
  • in this regard, echocardiography may be useful in confirming diastolic dysfunction [13]. (thefreelibrary.com)
  • Animals were dosed with doxorubicin (20 mg/kg i.p.), and left ventricular performance was assessed in vivo using M-mode and Doppler echocardiography. (aspetjournals.org)
  • 934 Measurement of basal ventricular asynchrony by real-time 3D long axis echocardiography Chung, R. (ebscohost.com)
  • An abstract of the article "Measurement of basal ventricular asynchrony by real-time 3D long axis echocardiography," by R. Chung, W. Li, and M. Y. Henein is presented. (ebscohost.com)
  • In a cross-sectional survey of 2000 men and women aged 25-74, randomly sampled from one geographical area, we assessed left- ventricular systolic function by echocardiography. (gla.ac.uk)
  • Subclinical left ventricular dysfunction, 2-dimensional speckle tracking echocardiography, Global longitudinal strain. (eurekaselect.com)
  • Prasad Gunasekaran, Sidakpal Panaich, Alexandros Briasoulis, Shaun Cardozo and Luis Afonso, "Incremental Value of Two Dimensional Speckle Tracking Echocardiography in the Functional Assessment and Characterization of Subclinical Left Ventricular Dysfunction", Current Cardiology Reviews (2017) 13: 32. (eurekaselect.com)
  • Persistent LV dysfunction was noted in 28% hospital survivors on follow-up echocardiography. (elsevier.com)
  • 112 Heart failure with preserved and depressed left ventricular systolic function: features and prognosis in a multicenter registry of 4720 patients. (ebscohost.com)
  • Left ventricular ejection fraction (LVEF) at rest was normal in 18 patients and abnormal in 5. (annals.org)
  • A normal LVEF response during exercise was shown in only 5 of the patients with normal resting left ventricular function. (annals.org)
  • Plasma BNP levels also increase with decreasing physiological functional capacities, as measured by left ventricular ejection fraction (LVEF) or exercise-based evaluations [9]. (thefreelibrary.com)
  • Traditionally, LV systolic function has been expressed in terms of left ventricular ejection fraction (LVEF), referring to the fraction of LV end-diastolic volume ejected during systole. (onlinejacc.org)
  • LV systolic dysfunction (ejection fraction [EF] ≤50%) was present in 32% (n = 119/376) and 20% had moderate or severe LV diastolic dysfunction with a preserved LVEF. (acc.org)
  • However, little evidence exists to demonstrate that cardiac-resynchronization therapy (CRT) benefits patients with HFpEF, despite a study showing a clinical and structural improvement in patients with a mean left ejection fraction (LVEF) of 43±7% after CRT [ 7 ]. (medsci.org)
  • BACKGROUND: Cardiac contractility modulation (CCM) is a treatment option for patients suffering symptomatic chronic heart failure (CHF) with reduced left ventricular ejection fraction (LVEF) who are not eligible for cardiac resynchronization. (minervamedica.it)
  • Upgrading to a biventricular device was associated with a decrease in the symptoms and ventricular dyssynchrony, and increased left ventricular ejection fraction (LVEF). (springermedizin.de)
  • Subclinical left ventricular (LV) dysfunction refers to subtle abnormalities in LV function which typically precede a reduction in the left ventricular ejection fraction (LVEF). (eurekaselect.com)
  • Children who had undergone BAV for AVS and LV dysfunction within the age range of six to 192 months showed a significant reduction in peak-to-peak pressure gradient (PPG) from 73.5 ± 30 mmHg to 26.7 ± 6.7 mmHg and improvement in LVEF from 32.8 ± 11% to 54.3 ± 12.7% after 24 hours. (cureus.com)
  • Left Ventricular Dysfunction: PERJETA can result in subclinical and clinical cardiac failure manifesting as decreased LVEF and CHF. (rxlist.com)
  • Hawthorn (Crataegus) reduces the incidence of sudden cardiac death in patients with less compromised left ventricular function. (greenmedinfo.com)
  • We hypothesized that left ventricular diastolic dysfunction is an important element of HF regardless of ejection fraction. (unboundmedicine.com)
  • To investigate the potential underlying left ventricular myocardial dysfunction after chronic misuse of AAS in athletes by use of Doppler myocardial imaging (DMI) and strain rate imaging (SRI). (bmj.com)
  • Early and accurate recognition of myocardial dysfunction offers the potential to optimize the timing of intervention in severe AS. (onlinejacc.org)
  • The aim of the present study was to measure regional ventricular function at rest and during stress in order to assess if patients with Type II diabetes have subclinical myocardial dysfunction and if it is related to risk factors. (clinsci.org)
  • BACKGROUND: The mechanism of myocardial dysfunction in the remote, noninfarct-related regions is an unresolved issue to date. (kuleuven.be)
  • CONCLUSIONS: Remote myocardial dysfunction contributes significantly to the loss in global ventricular function. (kuleuven.be)
  • Thirty to fifty percent of patients presenting with signs and symptoms of heart failure have a normal left ventricular (LV) systolic ejection fraction. (nih.gov)
  • We investigated the effectiveness of plasma N-terminal atrial natriuretic peptide (NT-ANP) and brain natriuretic peptide (BNP) concentrations to show left-ventricular systolic dysfunction in a random sample of the general population. (nih.gov)
  • RESULTS The presence of type 2 diabetes was associated with more severe LV systolic and diastolic dysfunction 8 years later: LV ejection fraction was 2.98% (95% CI 0.46-5.51) lower, and left atrial (LA) volume index, LV mass index, and tissue Doppler-derived E/e′ were 3.71 mL/m 2 (1.20-6.22), 5.86 g/m 2.7 (2.94-8.78), and 1.64 units (0.95-2.33) higher, respectively. (diabetesjournals.org)
  • Data from the MONICA (Monitoring of Trends and Determinations in Cardiovascular Disease) registry have shown that hypertension and obesity-both associated with type 2 diabetes and arterial stiffness-independently predicted left atrial (LA) enlargement, a sensitive indicator of an elevated LV preload ( 3 ). (diabetesjournals.org)
  • Olsen FJ, Christensen LM, Krieger DW, Højberg S, Høst N, Karlsen FM, Svendsen JH, Christensen H, Biering-Sørensen T. Relationship between left atrial strain, diastolic dysfunction and subclinical atrial fibrillation in patients with cryptogenic stroke: the SURPRISE echo substudy. (harvard.edu)
  • Left atrial dysfunction relates to symptom onset in patients with heart failure and preserved left ventricular ejection fraction. (nih.gov)
  • Left atrial (LA) function has been related to HF symptoms. (nih.gov)
  • Background】Left ventricular diastolic dysfunction lead to left atrial stasis and thus increases a risk of left atrial appendage thrombus in patients with atrial fibrillation. (medworm.com)
  • We investigated whether left ventricular diastolic dysfunction is associated with embolic burden in patients with ischem ic stroke related to atrial fibrillation. (medworm.com)
  • Thrombi are generated in the left atrial appendage, and subsequent embolism into the cerebral circulation is a major cause of ischemic stroke. (medworm.com)
  • Abstract Cardiogenic stroke (CS), characteristic causes of which include atrial fibrillation (AF) and right-to-left shunting due to a patent foramen ovale (PFO), has a well-known tendency to be associated with a more extensive ischemic area. (medworm.com)
  • Heart structures such as the left atrial appendage (LAA) and PFO are potent. (medworm.com)
  • Additionally, the left atrial volume index, peak TR velocity and E/e' ratio were independent risk factors for lowering the IIEF-5 score. (physiciansweekly.com)
  • Incidence of atrial fibrillation in patients with either heart failure or acute myocardial infarction and left ventricular dysfunction: a cohort study. (sigmaaldrich.com)
  • We examined the incidence of new-onset atrial fibrillation in patients with left ventricular dysfunction. (sigmaaldrich.com)
  • A multicenter prospective cohort study indicated that the left atrial diameter index was significantly associated with the risk of stroke recurrence ( 8 ). (spandidos-publications.com)
  • duration (≥41 ms), and left atrial volume (≥57 ml), where cut-off values were based upon the 90th percentile in NGM. (njmonline.nl)
  • In patients, carvedilol is effective in controlling the ventricular rate response in atrial fibrillation (AF), with and without digitalis, and is useful in maintaining sinus rhythm after cardioversion, with and without amiodarone. (elsevier.com)
  • With the addition of echocardiographic variables, lower ejection fraction was associated with male gender, black race, prior myocardial infarction, and higher ventricular mass and lower relative wall thickness, pulse pressure, and body mass index. (ahajournals.org)
  • 10 With the development of echocardiographic methods that provide a high yield of quantitative LV measurements, it has become possible to determine the prevalence and correlates of LV systolic dysfunction in population-based samples of hypertensive patients. (ahajournals.org)
  • Accordingly, the present study was undertaken to assess the prevalence and clinical and echocardiographic correlates of mild and severe LV systolic dysfunction in hypertensive black and white women and men participating in the Hypertension Genetic Epidemiology Network (HyperGEN) Study. (ahajournals.org)
  • 6 Besides providing clinically relevant data, noninvasive scintigraphic and echocardiographic techniques have also helped to illuminate the complex perfusion, metabolic, and functional correlates of these states of reversible LV dysfunction, which remain subjects for debate. (ahajournals.org)
  • Patients with either symptomatic or asymptomatic LV dysfunction as defined by echocardiographic ejection fraction (mcmaster.ca)
  • 1 ) report an increased prevalence of left ventricular (LV) systolic dysfunction among patients with rheumatoid disease in comparison to the general population based on a visual estimate of echocardiographic LV ejection fraction. (onlinejacc.org)
  • Left ventricular (LV) global longitudinal strain (GLS) is an echocardiographic measure of LV systolic function that can be an indicator of early subclinical cardiac dysfunction, even when LV ejection fraction is normal. (columbia.edu)
  • Also comparing echocardiographic parameters of those patients who achieved glycemic control to their baseline results showed that mean value of interventricular septal dimension (IVSd) decreased from 1.12cm to 1.03 (p = 0.04), posterior wall dimension (PWd) decreased from 1.07-0.97 (p = 0.05) however diastolic dysfunction represented by isovolumic relaxation time (IVRT) and E/A did not show a statistically significant change. (scialert.net)
  • Echocardiographic examination two days after pacemaker implantation demonstrated a normal LV function (55%), a LV end-diastolic volume (LVEDV) of 84 mL, the absence of significant valvulopathy and an aortic pre-ejection period (PEP) of 160 ms. A ventricular dyssynchrony (80 ms between septal and lateral electromechanical delays) was also measured with tissue Doppler imaging (TDI). (springermedizin.de)
  • The aim of our study was to assess the association between coronary calcium score (CCS), conventional cardiovascular risk factors, and echocardiographic markers of subclinical left ventricular dysfunction (S-LVD). (edu.au)
  • The differences in the mean changes in left ventricular echocardiographic parameters between the treatment group and control group were evaluated. (biomedcentral.com)
  • This study suggests that the evaluation of NT-proBNP in asymptomatic patients with type 2 diabetes or hypertension may lead to very early exclusion of LV dysfunction. (scienceblog.com)
  • The most frequent comorbid conditions of heart failure with normal LV ejection fraction (HFNEF) (mainly characterized by LV diastolic dysfunction) are hypertension, type 2 diabetes, and obesity ( 1 ). (diabetesjournals.org)
  • PBI-4050 Reduces Pulmonary Hypertension, Lung fibrosis and Right Ventricular Dysfunction in Heart Failure. (annals.org)
  • However, the association between CI and left ventricular diastolic (LVD) dysfunction in young patients with hypertension has rarely been reported. (spandidos-publications.com)
  • The purpose of the present study was to investigate the association between LVD dysfunction and acute CI in young patients with hypertension. (spandidos-publications.com)
  • In conclusion, hypertension in the young is associated with decreased LVD function and is a risk factor for diastolic dysfunction of the left ventricle. (spandidos-publications.com)
  • Left atrium, left ventricular configuration and functional changes have been associated with acute CI in patients with hypertension or coronary heart disease ( 4 ). (spandidos-publications.com)
  • Although studies have suggested that the decline of LVD function is a transfer from a physiological to a pathological process and that an early manifestation of hypertension in heart damage is the reduction of diastolic function ( 12 ), there have been no clinical reports on the association between LVD dysfunction and CI among young patients with hypertension, to the best of our knowledge. (spandidos-publications.com)
  • 947 Mean longitudinal strain and strain rate: an index of assessing subclinical left ventricular dysfunction in hypertension Pavlopoulos, H. (ebscohost.com)
  • 0·001), but there was no difference between those with and without left-ventricular systolic dysfunction in the rate of hypertension without IHD. (gla.ac.uk)
  • Inhaled nitric oxide and inhaled prostaglandin E1: effect on left ventricular contractility when used for treatment of experimental pulmonary hypertension. (semanticscholar.org)
  • Aiming at the appropriate target for the treatment of pulmonary hypertension due to left heart disease. (semanticscholar.org)
  • Left ventricular dysfunction with pulmonary hypertension: part 2: prognosis, noninvasive evaluation, treatment, and future research. (semanticscholar.org)
  • The effectiveness of strategies for treatment of the altered static lung volume and against the development of bronchial hyperreactivity (BHR) following a left ventricular dysfunction (LVD) induced by myocardial ischaemia was investigated in a rat model of sustained postcapillary pulmonary hypertension. (biomedcentral.com)
  • The studies performed (complete laboratory work up, paracentesis, liver biopsy, echocardiogram, intrahepatic pressure measurements, etc.) showed a chylous ascites related to portal hypertension, and left ventricular dysfunction was the only probable cause found. (biomedcentral.com)
  • A normal electrocardiogram implies a low risk of left ventricular systolic dysfunction. (bmj.com)
  • PURPOSE: Research over the last decade with imaging methods showed that right ventricular (RV) intramyocardial fat (MF) deposition was found in „normal“ heart, as age-related process, after myocardial infarction and in pathophysiological condition as arrhythmogenic right ventricular. (ebscohost.com)
  • Moderate coffee consumption lowers the likelihood of developing left ventricular systolic dysfunction in post-acute coronary syndrome normotensive patients. (greenmedinfo.com)
  • His ventricular function has not deteriorated since starting enalapril 9 years ago and his cardiologist tells him to take this medication religiously. (drugs.com)
  • It is important to recognize that recovery of left ventricular function may occur in patients who have suffered sudden cardiac death and whose hearts may be suitable for transplantation. (ahajournals.org)
  • In these patients, recovery of left ventricular function after days or weeks may prevent the need for implantation of defibrillators or chronic therapy for severe left ventricular systolic dysfunction. (ahajournals.org)
  • Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. (greenmedinfo.com)
  • Curcumin improves left ventricular function in pressure overloaded rabbits. (greenmedinfo.com)
  • and (3) examine associations of LV systolic dysfunction with measures of LV geometry and valvular function. (ahajournals.org)
  • Poudel K, Shah AM, Michos ED, Folsom AR, Konety S, Lutsey PL. Association of serum calcium and phosphorus with measures of left ventricular structure and function: The ARIC study. (harvard.edu)
  • This is perhaps most important and most relevant in patients with a clinical syndrome of heart failure and a significant degree of global LV dysfunction, a subset of whom will derive considerable benefit in terms of outcome and recovery of LV function after revascularization. (ahajournals.org)
  • To determine whether longitudinal left ventricular systolic function measured by Doppler tissue imaging (DTI) after exercise can identify early left ventricular dysfunction in asymptomatic patients with moderate-severe aortic stenosis. (bmj.com)
  • These findings support the relationship of LA dysfunction with HFPEF, suggesting that the analysis of LA function may be useful in sinus rhythm patients with new-onset dyspnoea. (nih.gov)
  • The purpose of this study was to analyze whether long-term treatment with the nonselective beta-adrenergic blocking agent carvedilol may have beneficial effects in patients with dilated cardiomyopathy (DCM), who are poor responders in terms of left ventricular (LV) function and exercise tolerance to chronic treatment with the selective beta-blocker metoprolol. (nih.gov)
  • In DCM patients who were poor responders to chronic metoprolol, carvedilol treatment was associated with favorable effects on LV systolic function and remodeling as well as on ventricular arrhythmias, whereas it had a negative effect on peak oxygen consumption. (nih.gov)
  • There are some reports on negative effects of VA-ECMO on cardiac function, such as left ventricular (LV) dilatation and cardiac stun, but the support in the literature is scarce. (diva-portal.org)
  • Left ventricular ejection fraction, stroke work, and maximum rate of pressure change decreased comparably in both groups as a function of time on ECMO. (diva-portal.org)
  • Coronary microvascular dysfunction (CMD) has been proposed as a link between abnormal renal function and impairment of cardiac function and CV events. (medworm.com)
  • Exercise radionuclide angiography was used to assess the incidence of subclinical abnormalities of left ventricular function in 23 asymptomatic patients with thalassemia major. (annals.org)
  • After 1 year of intensive chelation therapy in these 12 patients, left ventricular function was reassessed. (annals.org)
  • This study is designed to compare left ventricular diastolic function among patients divided by brachial-ankle pulse wave velocity (baPWV) and corrected P wave dispersion (PWDC) and assess whether the combination of baPWV and PWDC can predict LVDD more accurately. (medsci.org)
  • We describe the cases of three patients with well-documented severe left ventricular dysfunction due to doxorubicin who had complete clinical recovery with return of cardiac function to normal. (annals.org)
  • Regional left ventricular (LV) function has not been systematically studied in ARVD. (scialert.net)
  • The χ ² test was used to compare the left ventricular diastolic function between the CI and non‑CI groups. (spandidos-publications.com)
  • 356 Clinical characteristics of patients referred with suspected heart failure and preserved left ventricular systolic function. (ebscohost.com)
  • An abstract of the study "Clinical characteristics of patients referred with suspected heart failure and preserved left ventricular systolic function," by C. Constantin and colleagues is presented. (ebscohost.com)
  • An abstract of the study "Heart failure with preserved and depressed left ventrricular systolic function: features and prognosis in a multicenter registry of 4720 patients," by J. C. Castillo and colleagues is presented. (ebscohost.com)
  • 509 Therapy with Vagus nerve electrical stimulation combined with beta-blockade improves left ventricular systolic function in dogs with heart failure beyond that seen with beta-blockade alone. (ebscohost.com)
  • 389 Right ventricular diastolic function abnormalities in patients with type 1 diabetes. (ebscohost.com)
  • An abstract of the study "Right Ventricular Diastolic Function Abnormalities in Patients With Type 1 Diabetes," by D. Beldekos and colleagues is presented. (ebscohost.com)
  • We sought to assess left ventricular (LV) dyssynchrony and function in HFpEF and elucidate the underlying mechanisms that may account for HFpEF. (medsci.org)
  • Left ventricular diastolic dysfunction (LVDD) has long been considered as the main cause of HFpEF, however, large previous clinical trials failed to improve the prognosis of HFpEF by restoring LV diastolic function[ 3 , 4 , 5 ]. (medsci.org)
  • In conclusion, patients with Type II diabetes and no clinical heart disease have impaired subendocardial function of the left ventricle at rest and peak stress, which is related to glycated haemoglobin and serum low-density lipoprotein-cholesterol. (clinsci.org)
  • It has been known for close to half a century that left ventricular (LV) function is of prognostic significance in cardiovascular disease. (onlinejacc.org)
  • These results suggest that left ventricular cardiac muscle has the capacity to respond to stress despite hypokinetic and poor ventricular function at baseline. (ahajournals.org)
  • The aim of this study is to assess the impact of CCM on quality of life, symptoms, exercise tolerance and left ventricular function in patients with CHF and moderate-to- severe left ventricular systolic dysfunction. (minervamedica.it)
  • Investigating a diabetic rat model, ECG-gated \(^{18}\)F-FDG PET imaging detected LV diastolic dysfunction while systolic function was still preserved. (uni-wuerzburg.de)
  • Magnetic resonance tagging provided information on the regional ventricular morphology and function. (kuleuven.be)
  • We report the case of a 55-year-old Tunisian woman with preserved ventricular function, implanted with a dual-chamber pacemaker for complete atrioventricular block. (springermedizin.de)
  • To date it is not known whether diffuse interstitial myocardial fibrosis is present before the onset of heart failure symptoms or changes in conventional parameters of left ventricular function. (biomedcentral.com)
  • All subjects underwent cardiac MRI (1.5 T) to assess ventricular function, diffuse interstitial myocardial fibrosis by measurement of extracellular volume on T1-mapping (MOLLI) and coarse replacement fibrosis using standard late gadolinium enhancement imaging. (biomedcentral.com)
  • Diffuse interstitial myocardial fibrosis is common in Alström syndrome and is associated with impaired left ventricular systolic function. (biomedcentral.com)
  • 1) to establish whether diffuse interstitial myocardial fibrosis is present in asymptomatic adult subjects with ALMS, 2) if present, determine whether this is associated with change in left ventricular function. (biomedcentral.com)
  • 1. Improvement in left ventricular function and coronary perfusion reserve based on assessment by gadolinium-enhanced rest/stress (adenosine) cine CMR. (isrctn.com)
  • 2. To confirm the hypothesis that the degree of improvement in left ventricular function is affected by the extent of viable myocardium. (isrctn.com)
  • In this research, an extension to our previous work published in the Clinical Journal of Sports Medicine in 2009, we studied subjects that differed in terms of age and training status and assessed the impact of prolonged exercise on systolic and left ventricular diastolic function and cardiac biomarkers levels, recognized as identifiers of cardiac damage and dysfunction. (biomedcentral.com)
  • We also assessed the possible influence of event duration, exercise intensity and weight loss (dehydration) on left ventricular diastolic function. (biomedcentral.com)
  • Echocardiograph results indicated that left ventricular diastolic and systolic function decreased after the race, with systolic function reduced to a significant degree. (biomedcentral.com)
  • The decrease in left ventricular systolic and diastolic function did not correlate with age, training status, race duration, weight loss or exercise intensity. (biomedcentral.com)
  • Left ventricular systolic and diastolic function was reduced and cardiac biomarkers were increased after the cycling event, but the mechanisms behind such outcomes remain unclear. (biomedcentral.com)
  • Specific exercise parameters (training status and exercise intensity and duration) that may affect observed changes in biomarkers and ventricular systolic and diastolic function are poorly described and the mechanisms involved are not well understood. (biomedcentral.com)
  • To the best of our knowledge, the influence of exercise intensity on left ventricular function has not yet been determined, as we were unable to locate any studies of ventricular dysfunction in cyclists of different ages and training levels for a long-duration cycling event (6 hours or more). (biomedcentral.com)
  • Therefore, for a long-duration cycling test, we studied, following a similar study [ 19 ], the influence of age, level of training, exercise intensity, event duration and weight loss (dehydration) on ventricular function and their association with cardiac biomarkers. (biomedcentral.com)
  • Therefore, the aim of this study was to evaluate outcomes to establish the safety and effectiveness of BAV in children with AVS and LV dysfunction in improving LV function and survival. (cureus.com)
  • Our data suggest that BAV in children with aortic stenosis and LV dysfunction is safe and effective in the normalization of LV function. (cureus.com)
  • Nonetheless, only half of those with hyperthyroidism-related heart failure have impaired left ventricular (LV) systolic function. (hku.hk)
  • All patients had normal LV systolic function, but diastolic dysfunction was detected in 22 cases (mild: 3, moderate: 15 and severe: 4). (hku.hk)
  • The results of previous clinical and experimental studies clearly established that a left ventricular dysfunction (LVD) leads to a lung function impairment manifested in airflow limitation and compromised lung compliance [ 1 , 2 ]. (biomedcentral.com)
  • The two groups had similar baseline characteristics, but those with LV dysfunction had worse function as demonstrated by worse LV ejection fraction, cardiac index, and LV diastolic dysfunction. (elsevier.com)
  • In patients with AF and heart failure (HF), carvedilol reduces mortality risk and improves left ventricular (LV) function. (elsevier.com)
  • An early nonrandomized pilot study showed improved left ventricular function when glucagon-like peptide-1 (GLP-1) agonists were infused in patients with acute myocardial infarction and HF [ 3 ]. (biomedcentral.com)
  • Empagliflozin improved adverse anatomic LV remodeling, enhanced left ventricular systolic function, and inhibited neurohormonal activation. (biomedcentral.com)
  • Symptoms of heart failure with preserved left ventricular systolic function are common among patients undergoing peritoneal dialysis (PD). (biomedcentral.com)
  • This was a cross-sectional study of 149 patients with preserved left ventricular systolic function who were undergoing PD. (biomedcentral.com)
  • 0.001) in left ventricular function in 8-month-old low-TF mice compared with age-matched wild-type mice. (elsevier.com)
  • The intracoronary injection of selected CD133(+) stem cells is secure and feasible in patients with left ventricle dysfunction following acute myocardial infarction. (greenmedinfo.com)
  • A condition in which the LEFT VENTRICLE of the heart was functionally impaired. (harvard.edu)
  • Background- Although arrhythmogenic right ventricular dysplasia (ARVD) predominantly affects the right ventricle (RV), genetic/molecular and histological changes are biventricular. (scialert.net)
  • The left ventricle (LV) plays a central role in the maintenance of health of children and adults due to its role as the major pump of the heart. (eurekaselect.com)
  • The left ventricle (LV) was divided into infarct, adjacent and remote regions. (kuleuven.be)
  • A cardiac ultrasound showed moderate to severe systolic left ventricle dysfunction with global hypokinesia and the inferolateral wall was akinesic. (biomedcentral.com)
  • The left ventricle diameters were normal and the left atria was enlarged (52 mm). (biomedcentral.com)
  • Systolic heart failure involves a loss of effective actin-myosin cross bridges in the myocytes (heart muscle cells) of the left ventricle, which leads to a decreased ability of the heart to move blood through the body. (wikipedia.org)
  • Myocardial viability assessment is typically reserved for patients with coronary artery disease and significant left ventricular dysfunction. (onlinejacc.org)
  • It is uncertain whether COVID-19 survivors are at risk cardiac dysfunction including cardiac arrhythmia and heart failure. (clinicaltrials.gov)
  • We sought to investigate the relationships between CKD, CMD, cardiac dysfunction and adverse CV outcomes. (medworm.com)
  • Levels of BNP have been shown to be elevated in patients with cardiac dysfunction [4, 5]. (thefreelibrary.com)
  • NT-proBNP levels also rise more gradually for a given level of cardiac dysfunction. (thefreelibrary.com)
  • NT-proBNP appears to be a more discerning marker of early cardiac dysfunction than BNP [20-21]. (thefreelibrary.com)
  • These data demonstrate that alteration of cardiac nitric oxide control and attendant peroxynitrite formation may be an important contributor to doxorubicin-induced cardiac dysfunction. (aspetjournals.org)
  • Thus, although the clinical importance of DOX-related cardiac dysfunction and toxicity is widely recognized, the precise cellular events involved have not been established, and optimal therapeutic approaches for cardioprotection are not fully defined. (aspetjournals.org)
  • Cardiac dysfunction consequently leads to a cascade of molecular events to maintain physiological equilibrium. (onlinejacc.org)
  • A challenging clinical scenario remains: the patient with severe cardiac dysfunction receiving optimal medical therapy (OMT) and carrying significant surgical risk. (onlinejacc.org)
  • We will review the pathophysiological events in ischemic cardiac dysfunction, noninvasive strategies to image viable myocardium, and the current published reports regarding patient outcomes with decisions aided by viability testing. (onlinejacc.org)
  • Cardiac dysfunction is now a major cause of death in patients with Duchenne muscular dystrophy (DMD), and that the dystrophin genotype probably does not predict the course of the cardiomyopathy. (bmj.com)
  • The cardiac dysfunction observed in the hypoxic myoglobin-null mice was reversible with reexposure to normoxic conditions and could be prevented with treatment of an inhibitor of nitric oxide (NO) synthases. (umn.edu)
  • These results support the conclusion that hypoxia-induced cardiac dysfunction in myoglobin-null mice occurs via a NO-mediated mechanism. (umn.edu)
  • Diastolic dysfunction was found in 368 subjects (36%) and was categorized as mild in 327 and moderate-severe in 41. (scienceblog.com)
  • CONCLUSIONS Both glucose status and arterial distensibility are independently associated with more severe LV diastolic dysfunction 8 years later and with deterioration of LV diastolic dysfunction. (diabetesjournals.org)
  • In asymptomatic patients with moderate-severe aortic stenosis a lower than normal increase in peak systolic mitral annular velocity after treadmill exercise is a marker of early left ventricular systolic dysfunction. (bmj.com)
  • Left ventricular (LV) systolic dysfunction is an adverse consequence of the pressure overload of severe aortic stenosis (AS). (onlinejacc.org)
  • Limiting dyspnea was reported in 63% of patients (n = 57/90) with systolic dysfunction and 60% (n = 30/50) of patients with moderate or severe diastolic dysfunction. (acc.org)
  • We have previously shown that the selective destruction of Pnmt+ cells in the mouse produces severe left-ventricular dysfunction under anesthesia and that epinephrine deficiency alone does not recapitulate the phenotype. (ahajournals.org)
  • RVS pacing induced a major ventricular dyssynchrony, severe left ventricular ejection fraction deterioration and symptoms of congestive heart failure. (springermedizin.de)
  • Four patients died, all of whom had severe LV dysfunction - one died during the procedure and three died within six to 20 hours after successful BAV. (cureus.com)
  • In patients with severe sepsis and septic shock, the presence of new-onset LV dysfunction did not increase the risk of long-term adverse heart failure outcomes. (elsevier.com)
  • Equally important is the appreciation of the transient nature of left ventricular systolic dysfunction in patients suffering from acute myocardial infarction and undergoing successful reperfusion. (ahajournals.org)
  • We conducted a double-blind, placebo-controlled study evaluating the effect of eplerenone, a selective aldosterone blocker, on morbidity and mortality among patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure. (unboundmedicine.com)
  • The primary end points were death from any cause and death from cardiovascular causes or hospitalization for heart failure, acute myocardial infarction, stroke, or ventricular arrhythmia. (unboundmedicine.com)
  • The addition of eplerenone to optimal medical therapy reduces morbidity and mortality among patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure. (unboundmedicine.com)
  • Microvascular obstruction remains a portent of adverse remodeling in optimally treated patients with left ventricular systolic dysfunction after acute myocardial infarction. (druglib.com)
  • BACKGROUND: Microvascular obstruction (MO) is associated with large acute myocardial infarction and lower left ventricular (LV) ejection fraction and predicts greater remodeling, but whether this effect is abolished by contemporary antiremodeling therapies is subject to debate. (druglib.com)
  • Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. (semanticscholar.org)
  • Patients with left ventricular systolic dysfunction after acute myocardial infarction represent a 'high-risk' cohort for adverse CVD outcomes. (bmj.com)
  • The aim of this study was to investigate the association between left ventricular diastolic dysfunction (LVDD) and erectile dysfunction (ED) without overt cardiovascular disease. (physiciansweekly.com)
  • The association between increased arterial stiffness and left ventricular diastolic dysfunction (LVDD) may be influenced by left ventricular performance. (medsci.org)
  • P wave dispersion is not only a significant determinant of left ventricular performance, but is also correlated with LVDD. (medsci.org)
  • Screening patients by means of baPWV and PWDC might help identify the high risk group of elevated left ventricular filling pressure and LVDD. (medsci.org)
  • Seventy-eighty patients with a narrow QRS complex including 47 with HFpEF, 31 with heart failure with reduced ejection fraction (HFrEF) patients, and 29 with asymptomatic left ventricular diastolic dysfunction (LVDD) were recruited. (medsci.org)
  • The aim of our current study is to assess the association between EpF and Left ventricular diastolic dysfunction (LVDD) in patients undergoing PD and to clarify the relationships among EpF, inflammation, and LVDD in this population. (biomedcentral.com)
  • It is being studied for a potential role in the treatment of left ventricular systolic heart failure. (wikipedia.org)
  • NT-proBNP levels, as predictor of left ventricular systolic and diastolic dysfunction in patients with chronic heart failure. (thefreelibrary.com)
  • Heart failure (HF) and left ventricular (LV) dysfunction are the most concerning and serious cardiovascular complications of cancer therapies and cause an increase in morbidity and mortality. (springer.com)
  • The Left Ventricular Dysfunction (Cardiovascular) pipeline guide also reviews of key players involved in therapeutic development for Left Ventricular Dysfunction and features dormant and discontinued projects. (openpr.com)
  • We read with great interest the recent Images in Cardiovascular Medicine article by Girod et al 1 regarding a case with tako-tsubo -like transient left ventricular dysfunction. (ahajournals.org)
  • Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Left Ventricular Dysfunction - Pipeline Review, H2 2019, provides an overview of the Left Ventricular Dysfunction (Cardiovascular) pipeline landscape. (marketresearch.com)
  • Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Left Ventricular Dysfunction - Pipeline Review, H2 2019, provides comprehensive information on the therapeutics under development for Left Ventricular Dysfunction (Cardiovascular), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (marketresearch.com)
  • Left Ventricular Dysfunction (Cardiovascular) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. (marketresearch.com)
  • The pipeline guide provides a snapshot of the global therapeutic landscape of Left Ventricular Dysfunction (Cardiovascular). (marketresearch.com)
  • The pipeline guide reviews pipeline therapeutics for Left Ventricular Dysfunction (Cardiovascular) by companies and universities/research institutes based on information derived from company and industry-specific sources. (marketresearch.com)
  • The pipeline guide reviews key companies involved in Left Ventricular Dysfunction (Cardiovascular) therapeutics and enlists all their major and minor projects. (marketresearch.com)
  • The pipeline guide evaluates Left Ventricular Dysfunction (Cardiovascular) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. (marketresearch.com)
  • Find and recognize significant and varied types of therapeutics under development for Left Ventricular Dysfunction (Cardiovascular). (marketresearch.com)
  • Formulate corrective measures for pipeline projects by understanding Left Ventricular Dysfunction (Cardiovascular) pipeline depth and focus of Indication therapeutics. (marketresearch.com)
  • The main mechanisms connected to OSA and involved in the genesis of cardiovascular diseases are sympathetic hyperactivity, endothelial dysfunction, systemic inflammation, insulin resistance, oxidative stress and coagulation anomalies 7 - 9 . (ersjournals.com)
  • Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. (semanticscholar.org)
  • Although a variety of antidiabetic drugs have significant protective action on the cardiovascular system, it is still unclear which antidiabetic drugs can improve ventricular remodeling and fundamentally delay the process of heart failure. (biomedcentral.com)
  • The purpose of this network meta-analysis is to compare the efficacy of sodium glucose cotransporter type 2 (SGLT-2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) agonists, metformin (MET), sulfonylurea (SU) and thiazolidinediones (TZDs) in improving left ventricular (LV) remodeling in patients with type 2 diabetes (T2DM) and/or cardiovascular disease (CVD). (biomedcentral.com)
  • Some cancer treatments induce left ventricular dysfunction that appears early after exposure and therefore may adversely affect oncological therapy, while others generate cardiac injuries resulting in clinical problems only years later. (springer.com)
  • The clinical impact of reversal of the left ventricular dysfunction seen with brain death 4,5 may hold great promise for patients awaiting a donor heart. (ahajournals.org)
  • 2,3,6,7 However, the proportion of cases of clinical CHF that are due to left ventricular (LV) systolic dysfunction compared with LV diastolic dysfunction, valvular heart disease, or other causes is not well established. (ahajournals.org)
  • The compelling pathophysiology of the states of reversible LV dysfunction, myocardial hibernation, and myocardial stunning have spawned a voluminous literature as clinical investigators attempt to optimize the noninvasive identification of patients with these conditions before consideration of revascularization. (ahajournals.org)
  • Such techniques have direct relevance in patients with clinical syndromes associated with LV dysfunction. (ahajournals.org)
  • 3) Is the assessment of metabolic activity by itself sufficient for clinical decision making regarding revascularization in the setting of LV dysfunction? (ahajournals.org)
  • Coronary Microvascular Dysfunction, Left Ventricular Remodeling and Clinical Outcomes in Patients with Chronic Kidney Impairment. (medworm.com)
  • Despite the substantial differences in the EF, Both groups have reductions in exercise tolerance, neurohumoral activation, and abnormal left ventricular (LV) filling dynamics and impaired relaxation and have similar clinical symptoms and signs. (thefreelibrary.com)
  • Chronic heart failure (CHF) is currently recognized as a clinical syndrome occurring not only as a result of rnechanical dysfunction of the ventricles, but also due to complex molecular, endocrine, neuroendocrine, and inflammatory changes [3] Neurohormonal activation plays a fundamental role in the onset and progression of heart failure and the use of biochemical markers as prognostic indicators in heart failure have expanded in the last decade. (thefreelibrary.com)
  • Right ventricular dysfunction predicts clinical outcomes following cardiac resynchronization. (ebscohost.com)
  • An abstract of the paper "Right Ventricular Dysfunction Predicts Clinical Outcomes Following Cardiac Resynchronization," by Francisco Alpendurada and colleagues is presented. (ebscohost.com)
  • Clinical heart failure may ensue secondary to pump dysfunction and arrhythmias, causing significant morbidity and mortality. (onlinejacc.org)
  • Interpretation Left-ventricular systolic dysfunction was at least twice as common as symptomatic heart failure defined by clinical criteria. (gla.ac.uk)
  • OBJECTIVE: Epicardial atherosclerosis and heart failure while distinct clinical entities share common pathophysiological features including endothelial dysfunction and inflammation. (edu.au)
  • Large-scale clinical trials have demonstrated that combined carvedilol and angiotensin-converting enzyme inhibitor therapy significantly reduces sudden cardiac death, mortality, and ventricular arrhythmia in patients with LV dysfunction (LVD) due to chronic HF or following myocardial infarction (MI). (elsevier.com)
  • Thus, the overall clinical result of omecamtiv mecarbil is an increase in left ventricular systolic ejection time and ejection fraction. (wikipedia.org)
  • An abstract of the study "The Effect of Diuretics on Peak Oxygen Consumption and Quality of Life in Patients With Compensated Left Ventricular Dysfunction," by S. Gupta and colleagues is presented. (ebscohost.com)
  • An abstract of the study "Prevalence of Isolated Diastolic Dysfunction in Hospitalized Diabetic Patients: Correlations According to Different Line Treatment," by G. Pumilia and colleagues is presented. (ebscohost.com)
  • An abstract of the article "Magnetically guided left ventricular lead implantation in CRT patients," by M. Taborsky and colleagues is presented. (ebscohost.com)
  • An abstract of the article "First Step Towards the Definition of a Multidisciplinary Tool for Guidance to Work Eligibility in Patients With Left Ventricular Dysfunction," by S. De Feo and colleagues, is presented. (ebscohost.com)
  • An abstract of the study "A marker of early ventricular dysfunction in rheumatoid arthritis patients," by S. Abou-Raya and colleagues is presented. (ebscohost.com)
  • abstract = "study objective: To assess the natural history of isolated left ventricular diastolic dysfunction. (elsevier.com)
  • Early detection of left ventricular dysfunction with strain imaging in thalassemia patients. (biomedsearch.com)
  • In clinically stable asymptomatic patients with left ventricular dysfunction ( ejection fraction less than 35 percent), enalapril maleate decreases the rate of development of overt heart failure and decreases the incidence of hospitalization for heart failure. (rxlist.com)
  • What is the prevalence of left ventricular dysfunction (LVD) in those ≥85 years of age? (acc.org)
  • Conclusions Chronic ARB improves diastolic dysfunction in diabetic patients, at least partially through the attenuation of myocardial fibrosis, by regulating collagen turnover, particularly by facilitating collagen degradation. (go.jp)
  • Left ventricular wall motion abnormalities in patients with subarachnoid hemorrhage: neurogenic stunned myocardium. (ahajournals.org)
  • The present study examined the relationships between respiratory parameters and left ventricular abnormalities in OSA. (ersjournals.com)
  • In the derivation cohort, Cox regression models were constructed including cardiotoxic cancer treatment exposures with and without ejection fraction to estimate the probability developing left-ventricular dysfunction with an ejection fraction less than 40% (LVD40) at 10-year follow-up. (ascopost.com)
  • Liu S, Guan Z, Jin X, Meng P, Wang Y, Zheng X, Jia D, Ma C, Yang J. Left ventricular diastolic and systolic dyssynchrony and dysfunction in heart failure with preserved ejection fraction and a narrow QRS complex. (medsci.org)
  • Omega-3 fatty acid reduce the total mortality and sudden death in patients with left ventricular systolic dysfunction. (greenmedinfo.com)
  • Diastolic dysfunction is a better predictor of B-type natriuretic peptide levels and mortality than ejection fraction or left ventricular EDVI. (unboundmedicine.com)
  • Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. (acpjc.org)
  • To determine the effectiveness of d -sotalol for reducing all-cause mortality in patients with previous myocardial infarction (MI) and left ventricular (LV) dysfunction. (acpjc.org)
  • d -sotalol was associated with greater all-cause and cardiac mortality than was placebo in patients with previous myocardial infarction and left ventricular dysfunction. (acpjc.org)
  • Secondary outcomes included persistent LV dysfunction, and hospital mortality and length of stay. (elsevier.com)
  • Beta-blockers and ventricular arrhythmias in dilated cardiomyopathy. (nih.gov)
  • At least half of the deaths are caused by ventricular arrhythmias, prompting many anti-arrhythmic drug trials. (acpjc.org)
  • Among participants with left-ventricular systolic dysfunction, both symptomatic and asymptomatic subgroups had raised NT-ANP and BNP concentrations. (nih.gov)
  • 8,9 Furthermore, few data are available on the combined prevalence of symptomatic and asymptomatic LV systolic dysfunction in population samples, 6 especially of high-risk groups such as blacks. (ahajournals.org)
  • Our aim was to compare plasma concentrations of l -arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) in PAH compared to left ventricular systolic dysfunction (LVSD) and healthy subjects. (springer.com)
  • This study sought to evaluate the efficacy of enalapril and carvedilol to prevent chemotherapy-induced left ventricular systolic dysfunction (LVSD) in patients with hematological malignancies. (sigmaaldrich.com)
  • 334 The ECG in diagnosis of heart failure (HF) due to left ventricular systolic dysfunction (LVSD) � Is advice from guidelines flawed? (ebscohost.com)
  • see Heart failure#Systolic dysfunction Ligonier Valley School District in Westmoreland County, Pennsylvania This disambiguation page lists articles associated with the title LVSD. (wikipedia.org)
  • Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall. (harvard.edu)
  • 1 Patients usually present to their general practitioner but a definitive diagnosis of left ventricular systolic dysfunction can only be achieved by cardiac imaging. (bmj.com)
  • Plasma BNP levels provide clinically useful information concerning the diagnosis and management of left ventricular dysfunction and heart failure, which complements other diagnostic testing procedures (e.g., electrocardiograms, chest x-rays, and echocardiograms) [6,7]. (thefreelibrary.com)
  • OBJECTIVE To investigate relative contributions of glucose status and arterial stiffness to markers of left ventricular (LV) systolic and diastolic dysfunction after 8 years of follow-up. (diabetesjournals.org)
  • More arterial stiffness (measured as a lower distensibility) was associated with LV diastolic dysfunction 8 years later: LA volume index, LV mass index, and E/e′ at follow-up were higher. (diabetesjournals.org)
  • Subsequent adjustments for baseline mean arterial pressure and/or LV diastolic dysfunction did not eliminate these associations. (diabetesjournals.org)
  • Associations of type 2 diabetes and arterial stiffness with markers of LV diastolic dysfunction were largely independent of each other. (diabetesjournals.org)
  • Therefore, type 2 diabetes and arterial stiffness may relate to LV diastolic dysfunction through different pathways. (diabetesjournals.org)
  • Metabolic disturbances and arterial stiffness are both recognized contributors to left ventricular (LV) stiffness and LV systolic and diastolic dysfunction. (diabetesjournals.org)
  • These direct effects of arterial stiffening are thought to contribute to both systolic and diastolic LV dysfunction but predominantly to the former ( 7 , 8 ). (diabetesjournals.org)
  • Identification and treatment of patients with left ventricular systolic dysfunction improves survival and reduces morbidity. (bmj.com)
  • Enalapril and carvedilol for preventing chemotherapy-induced left ventricular systolic dysfunction in patients with malignant hemopathies: the OVERCOME trial (preventiOn of left Ventricular dysfunction with Enalapril and caRvedilol in patients submitted to intensive ChemOtherapy for the treatment of Malignant hEmopathies). (sigmaaldrich.com)
  • Long-term effects of carvedilol in idiopathic dilated cardiomyopathy with persistent left ventricular dysfunction despite chronic metoprolol. (nih.gov)
  • Experimentally, carvedilol reduces complex and repetitive ventricular ectopy induced by ischemia and reperfusion. (elsevier.com)
  • Cardiac injury, including left ventricular dysfunction, frequently occurs in patients with subarachnoid hemorrhage. (semanticscholar.org)