A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
A condition in which HEART VENTRICLES exhibit impaired function.
A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Contractile activity of the MYOCARDIUM.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
The hollow, muscular organ that maintains the circulation of the blood.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This abnormality is associated with high levels of CATECHOLAMINES, either administered or endogenously secreted from a tumor or during extreme stress.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Elements of limited time intervals, contributing to particular results or situations.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The hemodynamic and electrophysiological action of the right HEART VENTRICLE.
Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Pathological conditions involving the HEART including its structural and functional abnormalities.
The circulation of blood through the CORONARY VESSELS of the HEART.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
The span of viability of a tissue or an organ.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Examinations used to diagnose and treat heart conditions.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
Drugs used to cause dilation of the blood vessels.
Insurance coverage of a physical or mental health condition, disability, or illness existing before health insurance is applied for or enrolled in.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
The pressure within the CARDIAC ATRIUM. It can be measured directly by using a pressure catheter (see HEART CATHETERIZATION). It can be also estimated using various imaging techniques or other pressure readings such as PULMONARY CAPILLARY WEDGE PRESSURE (an estimate of left atrial pressure) and CENTRAL VENOUS PRESSURE (an estimate of right atrial pressure).
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
A condition characterized by the thickening of ENDOCARDIUM due to proliferation of fibrous and elastic tissue, usually in the left ventricle leading to impaired cardiac function (CARDIOMYOPATHY, RESTRICTIVE). It is most commonly seen in young children and rarely in adults. It is often associated with congenital heart anomalies (HEART DEFECTS CONGENITAL;) INFECTION; or gene mutation. Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis.
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Counterpulsation in which a pumping unit synchronized with the patient's electrocardiogram rapidly fills a balloon in the aorta with helium or carbon dioxide in early diastole and evacuates the balloon at the onset of systole. As the balloon inflates, it raises aortic diastolic pressure, and as it deflates, it lowers aortic systolic pressure. The result is a decrease in left ventricular work and increased myocardial and peripheral perfusion.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Physiological disturbances in normal sexual performance in either the male or the female.
The valve between the left atrium and left ventricle of the heart.
Disease having a short and relatively severe course.
A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).
The chambers of the heart, to which the BLOOD returns from the circulation.
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
Surgery performed on the heart.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The measurement of visualization by radiation of any organ after a radionuclide has been injected into its blood supply. It is used to diagnose heart, liver, lung, and other diseases and to measure the function of those organs, except renography, for which RADIOISOTOPE RENOGRAPHY is available.
The period following a surgical operation.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.
The veins and arteries of the HEART.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.
Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
The blood pressure in the ARTERIES. It is commonly measured with a SPHYGMOMANOMETER on the upper arm which represents the arterial pressure in the BRACHIAL ARTERY.
The hemodynamic and electrophysiological action of the HEART VENTRICLES.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
The transference of a heart from one human or animal to another.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
Diseases that do not exhibit symptoms.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
Agents that promote the excretion of urine through their effects on kidney function.
An electrical current applied to the HEART to terminate a disturbance of its rhythm, ARRHYTHMIAS, CARDIAC. (Stedman, 25th ed)
A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE.
A phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist.
Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.
Drugs that bind to and block the activation of MINERALOCORTICOID RECEPTORS by MINERALOCORTICOIDS such as ALDOSTERONE.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
The condition of an anatomical structure's being dilated beyond normal dimensions.
The confinement of a patient in a hospital.
Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.
Peptides that regulate the WATER-ELECTROLYTE BALANCE in the body, also known as natriuretic peptide hormones. Several have been sequenced (ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; C-TYPE NATRIURETIC PEPTIDE).
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
The oxygen consumption level above which aerobic energy production is supplemented by anaerobic mechanisms during exercise, resulting in a sustained increase in lactate concentration and metabolic acidosis. The anaerobic threshold is affected by factors that modify oxygen delivery to the tissues; it is low in patients with heart disease. Methods of measurement include direct measure of lactate concentration, direct measurement of bicarbonate concentration, and gas exchange measurements.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Shock resulting from diminution of cardiac output in heart disease.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.

Global biventricular dysfunction in patients with asymptomatic coronary artery disease may be caused by myocarditis. (1/312)

BACKGROUND: The causal role of asymptomatic critical coronary artery obstruction in patients presenting with severe global biventricular dysfunction but no evidence of myocardial infarction is uncertain. METHODS AND RESULTS: Among 291 patients aged >40 years undergoing a noninvasive (2-dimensional echocardiography) and invasive (catheterization, coronary angiography, and biventricular endomyocardial biopsy, 6 to 8 samples/patient) cardiac study because of progressive heart failure (New York Heart Association functional class III or IV) with global biventricular dysfunction and no history of myocardial ischemic events, 7 patients (2.4%; 7 men; mean age, 49+/-6.9 years) had severe coronary artery disease (3 vessels in 4 patients; 2 vessels in 1 patient, proximal occlusion of left anterior descending coronary artery in 2 patients). Left ventricular end-diastolic diameter and ejection fraction by 2-dimensional echocardiography were 73+/-10.5 mm and 23+/-6.5%, respectively, and right ventricular end-diastolic diameter and ejection fraction were 39+/-7 mm and 29+/-7.2%, respectively. Biopsy specimens showed extensive lymphocytic infiltrates with focal myocytolysis meeting the Dallas criteria for myocarditis in all patients (in 5 patients with and 2 patients without fibrosis). Cardiac autoantibodies were detected with indirect immunofluorescence in the serum of 2 patients with active myocarditis. The 2 patients with active inflammation received prednisone (1 mg. kg-1. d-1 for 4 weeks followed by 0.33 mg. kg-1. d-1 for 5 months) and azathioprine (2 mg. kg-1. d-1 for 5 months) in addition to conventional drug therapy for heart failure. At 8-month overall follow-up, cardiac volume and function improved considerably in immunosuppressed patients but remained unchanged in conventionally treated patients, of whom 1 died. CONCLUSIONS: Global biventricular dysfunction in patients with severe asymptomatic coronary artery disease and no evidence of previous myocardial infarction may be caused by myocarditis. Histologic findings may influence the treatment.  (+info)

Prognostic value of dobutamine stress echocardiography in predicting cardiac events in patients with known or suspected coronary artery disease. (2/312)

OBJECTIVES: The study sought to determine the utility of dobutamine stress echocardiography (DSE) in predicting cardiac events in the year after testing. BACKGROUND: Increasingly, DSE has been applied to risk stratification of patients. METHODS: Medical records of 1,183 consecutive patients who underwent DSE were reviewed. The cardiac events that occurred during the 12 months after DSE were tabulated: myocardial infarction (MI), cardiac death, percutaneous transluminal coronary angioplasty (PTCA), and coronary artery bypass surgery (CABG). Patient exclusions included organ transplant receipt or evaluation, recent PTCA, noncardiac death, and lack of follow-up. A positive stress echocardiogram (SE) was defined as new or worsened wall-motion abnormalities (WMAs) consistent with ischemia during DSE. Classification and regression tree (CART) analysis identified variables that best predicted future cardiac events. RESULTS: The average age was 68+/-12 years, with 338 women and 220 men. The overall cardiac event rate was 34% if SE was positive, and 10% if it was negative. The event rates for MI and death were 10% and 8%, respectively, if SE was positive, and 3% and 3%, respectively, if SE was negative. If an ischemic electrocardiogram (ECG) and a positive SE were present, the overall event rate was 42%, versus a 7% rate when ECG and SE were negative for ischemia. Rest WMA was the most useful variable in predicting future cardiac events using CART: 25% of patients with and 6% without a rest WMA had an event. Other important variables were a dobutamine EF <52.5%, a positive SE, an ischemic ECG response, history of hypertension and age. CONCLUSIONS: A positive SE provides useful prognostic information that is enhanced by also considering rest-wall motion, stress ECG response, and dobutamine EF.  (+info)

Design and results of the antiarrhythmics vs implantable defibrillators (AVID) registry. The AVID Investigators. (3/312)

BACKGROUND: The Antiarrhythmics Versus Implantable Defibrillators (AVID) Study compared treatment with implantable cardioverter-defibrillators versus antiarrhythmic drugs in patients with life-threatening ventricular arrhythmias (VAs). AVID maintained a Registry on all patients, randomized or not, with any VA or unexplained syncope who could be considered for either of the treatment strategies. Trial-eligible arrhythmias were the categories of VF cardiac arrest, Syncopal VT, and Symptomatic VT, below. METHODS AND RESULTS: Of 5989 patients screened, 4595 were registered and 1016 were randomized. Mortality follow-up through 1996 was obtained on the 4219 Registry patients enrolled before 1997 through the National Death Index. Crude mortality rates (mean+/-SD, follow-up, 16.9+/-11.5 months) were: VF cardiac arrest, 17.0% (n=1399, 238 deaths); Syncopal VT, 21.2% (n=598, 127 deaths); Symptomatic VT, 15.8% (n=1065, 168 deaths); Stable (asymptomatic) VT, 19.7% (n=497, 98 deaths); VT/VF with transient/correctable cause, 17.8% (n=270, 48 deaths); and Unexplained syncope, 12.3% (n=390, 48 deaths). CONCLUSIONS: Patients with seemingly lower-risk or unknown-risk VAs (asymptomatic VT, and VT/VF associated with a transient factor) have a (high) mortality similar to that of higher-risk, AVID-eligible VAs. The similar (and poor) prognosis of most patients with VT/VF suggests the need for reevaluation of a priori risk grouping and raises the question of the appropriate arrhythmia therapy for a broad range of patients.  (+info)

Myocardial ischaemia in children with isolated ventricular non-compaction. (4/312)

AIMS: Isolated ventricular non-compaction is a rare congenital cardiomyopathy with a high morbidity and mortality due to malignant arrhythmias and pump failure. Areas affected by non-compaction are characterized by increased trabecularization and deep inter-trabecular spaces. We hypothesized perfusion defects in these areas and performed positron emission tomography to evaluate the myocardial perfusion in non-compacted areas. METHODS AND RESULTS: Five children (age 10-14 years) with isolated ventricular non-compaction underwent positron emission tomography using N-13-ammonia as flow marker and intravenous dipyridamole for stress testing. Myocardial blood flow was quantified using the positron emission tomography time-activity curves in non-compacted areas and normal myocardium, which were diagnosed by echocardiography, magnetic resonance imaging, and angiography. Coronary angiography, performed in two children with extensive forms of left ventricular non-compaction, demonstrated normal coronary arteries. Myocardial blood flow measurements at rest and after dipyridamole application demonstrated 16-33% and 32-57% perfusion impairment, respectively, in non-compacted areas compared to normal myocardium. Areas of restricted myocardial perfusion corresponded well to the non-compacted areas, defined echographically and by magnetic resonance imaging. CONCLUSION: Positron emission tomography demonstrates restricted myocardial perfusion and decreased flow reserve in areas of ventricular non-compaction in children. The myocardial perfusion defects in non-compacted areas may be the cause of myocardial damage and possibly form the basis of arrhythmias and pump failure.  (+info)

Abnormal cardiac repolarization and impulse initiation in German shepherd dogs with inherited ventricular arrhythmias and sudden death. (5/312)

OBJECTIVE: We tested the hypothesis that delayed afterdepolarization (DAD)-associated rhythms in German shepherd dogs with reduced anteroseptal left ventricular (LV) sympathetic innervation derive from abnormal beta-adrenergic receptor effector coupling. METHODS AND RESULTS: In anteroseptal LV midmyocardium of afflicted dogs, beta-receptor density was greater than that in normal dogs (P < .05), with affinity being equal in both groups. Basal and maximum isoproterenol (ISO) stimulated adenylyl cyclase activity of anteroseptal LV of afflicted dogs was greater than that in normal dogs (P < .05). Isolated anteroseptal M cell preparations of afflicted dogs studied with microelectrodes showed abnormal lengthening, rather than shortening of action potential duration in response to ISO, as well as a 61% incidence of 10(-7) mol/l ISO-induced triggered activity as compared to 12% in normals (P < .05). In contrast, there was no difference between afflicted and control dogs in triggered activity, beta-receptors or adenylyl cyclase activity in a normally innervated region of the ventricles. CONCLUSION: In this model there is an increase in beta-receptor density and beta-adrenergic stimulation of adenylyl cyclase and of triggered activity in anteroseptal myocardium but not in a normally innervated region of the heart. Hence, abnormal beta-adrenergic signal transduction appears associated with the neural abnormality identified in dogs with inherited VT.  (+info)

Losartan improves diastolic ventricular filling of hypertensive patients with diastolic dysfunction. (6/312)

To evaluate the role of losartan on left ventricular (LV) function of hypertensive patients. Hypertensive patients (n = 19) underwent evaluation of systolic and diastolic LV function, using radionuclide ventriculography (RVG), before and at 3 mo into the treatment with the angiotensin II antagonist losartan. All patients underwent a baseline 12 lead ECG and an echocardiogram (ECHO), which was also repeated at 3 mo into treatment. Results are expressed as mean +/- SEM and statistics were performed using paired t-test. A p value < or = 0.05 was considered significant. Treatment with losartan for 3 mo had no effect on LV mass measured by echo (141+/-5 vs. 139+/-6 g/m2). The LV ejection fraction, measured by RVG, was unchanged by treatment when compared to the baseline study (58+/-2% vs. 57+/-2%, respectivelly, p = 0.49). Considering all patients involved in the study (n = 19), the LV "Peak Filling Rate" (PFR), a parameter of diastolic function measured by RVG, was also unchanged by treatment when compared to baseline (2.5+/-0.2 EDV/s vs. 2.5+/-0.3 EDV/s, respectively, p = 0.9). However the analysis of those patients with evidence of diastolic dysfunction (n = 12) on the baseline RVG (PFR < 2.5 EVD/s), demonstrated significant improvement of LV filling after therapy with losartan (PFR = 1.8+/-0.1 EDV/s vs. 2.3 +/-0.2 EDV/s, respectively, p = 0.05). This change was associated with improvement of symptoms. Our results demonstrated that hypertensive patients with diastolic dysfunction on radionuclide ventriculography have significant improvement of ventricular filling at 3 mo into treatment with losartan.  (+info)

Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia. (7/312)

BACKGROUND: To date, the lack of potent and selective inhibitors has hampered the physiological assessment of modulation of the cardiac slowly activating delayed rectifier current, I(Ks). The present study, using the I(Ks) blocker L-768,673, represents the first in vivo assessment of the cardiac electrophysiological and antiarrhythmic effects of selective I(Ks) blockade. METHODS AND RESULTS: In an anesthetized canine model of recent (8.5+/-0.4 days) anterior myocardial infarction, 0.003 to 0.03 mg/kg L-768,673 IV significantly suppressed electrically induced ventricular tachyarrhythmias and reduced the incidence of lethal arrhythmias precipitated by acute, thrombotically induced posterolateral myocardial ischemia. Antiarrhythmic protection afforded by L-768,673 was accompanied by modest 7% to 10% increases in noninfarct zone ventricular effective refractory period, 3% to 5% increases in infarct zone ventricular effective refractory period, and 4% to 6% increases in QTc interval. In a conscious canine model of healed (3 to 4 weeks) anterior myocardial infarction, ventricular fibrillation was provoked by transient occlusion of the left circumflex coronary artery during submaximal exercise. Pretreatment with 0.03 mg/kg L-768,673 IV elicited a modest 7% increase in QTc, prevented ventricular fibrillation in 5 of 6 animals, and suppressed arrhythmias in 2 additional animals. CONCLUSIONS: The present findings suggest that selective blockade of I(Ks) may be a potentially useful intervention for the prevention of malignant ischemic ventricular arrhythmias.  (+info)

Baroreflex sensitivity predicts the induction of ventricular arrhythmias by cesium chloride in rabbits. (8/312)

Previous studies have shown that the autonomic nervous system plays an important role in the genesis of ventricular tachycardia (VT) in patients with long QT syndrome, and in cesium chloride (Cs)-induced VT in animals. The present study investigated whether baroreflex sensitivity predicts the induction of VT by Cs in the rabbit in vivo. Monophasic action potentials (MAPs) of the left ventricular endocardium were recorded simultaneously with the surface ECG in 27 rabbits. Rabbits were divided into 4 groups based on the Cs-induced ventricular arrhythmias: (1) no ventricular premature contractions (No-VPC group), (2) single or paired VPC (VPC group), (3) monomorphic VT (MVT group), and (4) polymorphic VT (PVT group). Baroreflex sensitivity was significantly lower in the MVT and PVT groups than in the No-VPC and VPC groups. The plasma norepinephrine concentration before Cs injection was significantly higher in the MVT group than in the other 3 groups, and the norepinephrine concentration after Cs injection was significantly higher in the MVT and PVT groups than in the No-VPC and VPC groups. Baroreflex sensitivity was negatively correlated with the norepinephrine concentration before Cs injection. These results suggest that autonomic nervous system dysfunction, as defined by reduced baroreflex sensitivity, and elevated plasma norepinephrine concentrations predict increased susceptibility to Cs-induced VT.  (+info)

The CELLWAVE double-blind, randomized, placebo-controlled trial was conducted among patients with CHF treated at Goethe University Frankfurt, Germany, between 2006 and 2011. This was a single-blind study of low-dose (n = 42), high-dose (n = 40), or placebo (n = 21) shock wave pretreatment targeted to the LV anterior wall. Twenty-four hours later, patients receiving shock wave pretreatment were randomized to receive double-blind intracoronary infusion of BMCs or placebo, and patients receiving placebo shock wave received intracoronary infusion of BMCs. The primary endpoint was change in LVEF from baseline to 4 months in the pooled groups shock wave + placebo infusion versus shock wave + BMCs; secondary endpoints included regional LV function assessed by magnetic resonance imaging and clinical events.. ...
PGD is a life-threatening complication of heart transplantation that presents as left, right or biventricular dysfunction occurring within the first 24 hours of transplant surgery for which there is no identifiable secondary cause (see Section 4.8). Severe PGD may be irreversible.. For patients who are on the heart transplant waiting list, consideration should be given to use an alternative antiarrhythmic drug as early as possible before transplant.. Section 4.8. Musculoskeletal and Connective Tissue Disorders:. ...
The diagnosis of idiopathic dilated cardiomyopathy should not be made without first performing a coronary angiogram. If the cause of heart failure is unknown this should be stated rather than attributing the cause to dilated cardiomyopathy. Severe ventricular dysfunction may improve dramatically after revascularisation in some cases of coronary disease. Preservation of R waves on the surface electrocardiogram suggests the presence of hibernating myocardium but thallium scintigraphy or positron emission tomography scanning should be employed to investigate this further.. ...
April 18, 2021. The daylong workshops incorporate the HeartWorks TEE Simulator, a solution for developing cognitive and psychomotor skills for TEE. Users see real-time, seamless ultrasound imaging in synchronization with their movement of the TEE probe, providing a realistic and accurate training experience in preparation for real patient examinations.. Shields said 20 pathologies, including aortic stenosis, mitral regurgitation, biventricular dysfunction and cardiac tamponade, are featured in the training, along with interventional use for transcatheter procedures.. Ultrasound allows us to see the structures of the heart, the size, whether the heart valve is working efficiently, among other assessments, Shields said. We can look at different pathologies of the heart, such as the direction of blood flow, or whether theres a septal defect. Its used mainly for cardiopulmonary instability, blood pressure problems, and trouble with oxygenation and saturation.. Shields points to the fact that ...
Cardiac resynchronization therapy (CRT) improves functional classification among patients with left ventricle malfunction and ventricular electric conduction disorders. and a HF group of 42 subjects (53.12 15.05 years, LVEF < 35%) were studied. The proposed classifiers had hit rates of 90%, 50%, and 80% to distinguish between absent, mild, and moderate-severe interventricular dyssynchrony, respectively. For […] ...
Pheochromocytoma/paraganglioma (PPGL) are neuroendocrine tumors that can secrete catecholamines. The authors describe a challenging case who presented as stress cardiomyopathy and myocardial infarction (MI). A 76-year-old man, with a medical history of Parkinsons disease, type 2 diabetes mellitus, hypertension, dyslipidaemia and a previous inferior MI in 2001, presented to the emergency department due to chest pain, headaches and vomiting. He also reported worsening blood glucose levels and increasing constipation over the preceding weeks. BP was 185/89 mmHg (no other relevant findings). EKG had ST segment depression in leads V2-V6, T troponin was 600 ng/L (,14) and the echocardiogram showed left ventricular hypokinesia with mildly compromised systolic function. Nevertheless, he rapidly progressed to severe biventricular dysfunction. Coronary angiogram showed a 90% anterior descendent coronary artery occlusion (already present in 2001), which was treated with angioplasty/stenting. In the ...
Indications for Drugs ::. Mild to moderate hypertension, Chronic stable and vasospastic angina, Raynauds disease, Coronary Artery Disease, HTN, Stroke prevention. Drug Dose ::. Adult: PO Stable angina; HTN; Prinzmetals angina Initial: 5 mg once daily; If the desired therapeutic effect cannot be achieved within 2-4 weeks, the dose may be increased to a maximum dose of 10 mg once daily. Child: >12 yr Initially, 2.5 mg once daily, increased to 5 mg once daily if necessary. Elderly: Initially, 2.5 mg once daily. Hepatic impairment: Initially, 2.5 mg once daily.. Contraindication ::. Hypersensitivity to Amlodipine or other calcium channel antagonist, Severe hypertension.. Drug Precautions ::. Impaired liver or renal function, CHF, sick-sinus syndrome, severe ventricular dysfunction, hypertrophic cardiomyopathy, severe aortic stenosis. Caution when used in patients with idiopathic hypertrophic subaortic stenosis. Elderly, children. Pregnancy, lactation. Use in renal failure: Although Amlodipine is ...
Indications for Drugs ::. Mild to moderate hypertension, Chronic stable and vasospastic angina, Raynauds disease, Coronary Artery Disease, HTN, Stroke prevention. Drug Dose ::. Adult: PO Stable angina; HTN; Prinzmetals angina Initial: 5 mg once daily; If the desired therapeutic effect cannot be achieved within 2-4 weeks, the dose may be increased to a maximum dose of 10 mg once daily. Child: >12 yr Initially, 2.5 mg once daily, increased to 5 mg once daily if necessary. Elderly: Initially, 2.5 mg once daily. Hepatic impairment: Initially, 2.5 mg once daily.. Contraindication ::. Hypersensitivity to Amlodipine or other calcium channel antagonist, Severe hypertension.. Drug Precautions ::. Impaired liver or renal function, CHF, sick-sinus syndrome, severe ventricular dysfunction, hypertrophic cardiomyopathy, severe aortic stenosis. Caution when used in patients with idiopathic hypertrophic subaortic stenosis. Elderly, children. Pregnancy, lactation. Use in renal failure: Although Amlodipine is ...
DentalPlans detailed profile of GEORGE QUINTERO , DDS - Dentist in 42701. View plans, sample savings & pricing, patient reviews & practice information.
Reviews and ratings for lotensin when used in the treatment of left ventricular dysfunction. Share your experience with this medication by writing a review.
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Extracorporal shock wave therapy is performed prior to cell therapy for induction of therapeutic neovascularization and improvement of homing of bone marrow progenitor cells in patients with chronic ischemic heart disease following anterior myocardial infarction.. Shock waves can induce growth factor expression in the ischemic myocardium and might augment homing of autologous bone marrow mononuclear cells which are injected intracoronary 24 h following shock wave therapy ...
The cardiorenal syndrome generally focuses on left ventricular function, and the importance of the right ventricle as a determinant of renal function is described less frequently. In a cohort of critically ill patients with echocardiographic measurements obtained within 24 hours of admission to the intensive care unit, we examined the association of right ventricular function with acute kidney injury (AKI) and AKI-associated mortality. We also examined whether clinical measurement of volume overload modified the association between ventricular function and AKI in a subpopulation with documented admission physical examinations. Among 1879 critically ill patients with echocardiographic ventricular measurements, 43% (n = 807) had ventricular dysfunction-21% (n = 388), 9% (n = 167), and 13% (n = 252) with isolated left ventricular dysfunction, isolated right ventricular dysfunction, and biventricular dysfunction, respectively. Overall, ventricular dysfunction was associated with a 43% higher ...
Figure. QTc interval prolongation and an episode of polymorphic ventricular tachycardia are observed.. The biochemical parameters showed low serum potassium concentrations in 2 cases, whereas calcium and magnesium levels were normal in all patients. In addition, various toxic substances were detected in urine.. The echocardiogram showed severe biventricular dysfunction in 1 of the patients; ventricular function was normal in all others. After methadone was discontinued and magnesium sulfate, isoproterenol perfusion, and potassium supplements were started, polymorphic ventricular tachycardia disappeared within 7 hours of admission. After 2-3 days, methadone treatment was resumed at the usual doses, with the QTc interval progressively returning to normal in 3 cases; the fourth patient requested voluntary withdrawal before the study was completed.. DISCUSSION. Methadone has been widely used for the treatment of heroine addiction and chronic pain for more than 3 decades. It is generally ...
TY - JOUR. T1 - Evaluation of cardiac dyssynchrony with longitudinal strain analysisin 4-chamber cine MR imaging. AU - Kawakubo, Masateru. AU - Nagao, Michinobu. AU - Kumazawa, Seiji. AU - Chishaki, Akiko S.. AU - Mukai, Yasushi. AU - Nakamura, Yasuhiko. AU - Honda, Hiroshi. AU - Morishita, Junji. PY - 2013/12. Y1 - 2013/12. N2 - Purpose: We investigated the clinical performance of evaluation of cardiac mechanical dyssynchrony withlongitudinal strain analysis using four-chamber (4CH) cine magnetic resonance imaging (MRI).Materials and methods: We retrospectively enrolled 73 chronic heart failure patients (41 men, 32 women;mean age, 57 years, NYHA 2, 3, and 4) who underwent a cardiac MRI in the present study. The left ventricu-lar dyssynchrony (LVD) and interventricular dyssynchrony (IVD) indices were calculated by longitudinalstrain analysis using 4CH cine MRI. The LVD and IVD indices were compared by the Wilcoxon rank-sumtest between the patients with indication for cardiac resynchronization ...
Introduction: Liver disease (LD) is a known long-term complication in single ventricle patients who undergo Fontan procedures. Cardiopulmonary exercise test (CPET) variables are known to be associated with increased risk of hospitalization in Fontan patients but their association with liver disease is unknown.. Methods/Results: We retrospectively reviewed medical records from 2 tertiary academic institutions (Central Manchester University Hospitals, UK and University of California San Francisco, USA) and identified 114 adult Fontan patients (,18 years). LD was defined as grade IV fibrosis or cirrhosis on either ultrasound or computed tomographic imaging. Mean age was 30.9 ± 7.4 years, age at Fontan 7.9 ± 7.9 years, 56% were females, 63% underwent total cavopulmonary connection, 66% had New York Heart Association (NYHA) I, 42% had arrhythmias, 22% had systemic right ventricle and 35% had ventricular dysfunction. Of 81 patients with liver imaging data, 33 (41%) had LD. There were no differences ...
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Our pediatric urologists have the experience and sensitivity to care for children with voiding dysfunction in a way that helps them feel comfortable.
TY - JOUR. T1 - Cross-sectional assessment of haemostatic profile and hepatic dysfunction in Fontan patients. AU - Daems, Joelle Julius Nicolaas. AU - Attard, Chantal. AU - van den Helm, Suelyn. AU - Breur, Johannes. AU - DUdekem, Yves. AU - du Plessis, Karin. AU - Wilson, Thomas G.. AU - Winlaw, David. AU - Gentles, Thomas L.. AU - Monagle, Paul. AU - Ignjatovic, Vera. N1 - Funding Information: Funding This project was supported by a grant from the National Health and Medical Research Council (NHMRC Project Grant 1047923). Funding Information: Acknowledgements The authors acknowledge support provided to the Murdoch Childrens Research Institute by the Victorian Governments Operational Infrastructure Support Programme. Yves dUdekem is a NHMRC Clinician Practitioner Fellow (1082186). Publisher Copyright: © 2021 EDP Sciences. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.. PY - 2021/5/10. Y1 - 2021/5/10. N2 - Background Fontan-associated liver disease is ...
A meta-analysis by Lipinski et al. (5) included 10 of these trials (7 randomized, 3 cohort studies) on intracoronary cell injection (within the first 14 days after infarction), yielding 698 patients, of which 659 were available at follow-up (median follow-up of 6 months). In 2 trials (n = 126), peripheral blood cells were used for intracoronary infusion and in 8 investigations bone marrow-derived cells were used. For the pooled population, Lipinski et al. (5) found a significantly superior improvement in LVEF of 3.0% (95% confidence interval: 1.9% to 4.1%, p , 0.00001) for subjects receiving bone marrow transplantation in comparison with control subjects. Similarly, LV end-systolic volumes were reduced in patients receiving cell therapy by -7.4 ml (95% confidence interval: -12.2 to -2.7 ml, p , 0.002) compared with control subjects. Changes in end-diastolic volumes were not significantly different between groups in this meta-analysis.. Clinical end points, such as death, target vessel ...
In patients with one anatomical or functional ventricular chamber, which encompasses a spectrum of rare and complex congenital cardiac malformations, a staged surgical approach in view of an ultimate Fontan operation has become the procedure of choice. Especially in the earlier era, perioperative mortality was the leading cause of death. However, many patients have a long and high-quality life, continuously improved by a better understanding of Fontan hemodynamics and the refinement of the surgical procedures. Nevertheless, the prospect of eventual failure of the Fontan circulation remains a major concern. More specifically, evaluation of the pulmonary circulation becomes particularly important as the failing Fontan circulation has become a common indication for cardiac transplantation. Although essential, especially in the preoperative setting, a comprehensive evaluation of the pulmonary circulation remains difficult in this patient population. Our global hypothesis is that the absence of ...
SAN REMO, Italy (VN) - Colombian rider Carlos Quintero will spend the night in an Italian hospital after suffering a concussion, but he is not facing life-threatening injuries in the wake of a nasty fall in Milan-San Remo.. For a few moments Saturday afternoon it looked like cycling was facing another worst-case scenario when the Colombia-Coldeportes rider crashed heavily on the descent of Le Mànie. Television images of doctors hurriedly treating the Coldeportes rider brought back the horrible images of last years Giro dItalia, when Wouter Weylandt died during a similar high-speed fall.. There was no official word from the team, but race officials confirmed that Quintero suffered a concussion and momentarily lost consciousness in the wake of his crash.. He was later transported to a hospital where a CT scan ruled out any serious brain injury. X-rays revealed a fracture to his left cheekbone and shoulder blade and a contusion to his left lung. Doctors are keeping him in the hospital overnight ...
Homes for sale: 3829 S Quintero CIR S, Aurora, CO 80013 (MLS #: 6804637) with 4 beds, 2.0 baths, 1738 sqft, and listed for $470000.
Introduction: Experiments in dogs with left bundle branch block (LBBB) showed a strong relation between electrical (QRS-vector amplitude, QRSVampl) and mechanical interventricular dyssynchrony. We investigated this relation in patients with previously implanted devices for cardiac resynchronization therapy (CRT) using echocardiography and vectorcardiography.. Methods: To induce different degrees of left (LV) and right ventricular (RV) pre-excitation, single site LV pacing at many AV-delays was performed in 20 LBBB patients in sinus rhythm, and biventricular pacing at many VV-delays in 18 patients with complete AV-block. At all pacing settings 3D-vectorcardiograms and echocardiograms were recorded. QRSVampl was defined negative when the spatial vector direction differed ,90° from LBBB or RV-pacing. Interventricular mechanical dyssynchrony (IVMD) was determined from Doppler recordings and septal strain from speckle tracking. Septal systolic rebound stretch (SRS) and pre-stretch (SPS) were ...
In acute myocardial infarction (AMI), both tissue necrosis and edema are present and both might be implicated in the development of intraventricular dyssynchrony. However, their relative contribution to transient dyssynchrony is not known. Cardiovascular magnetic resonance (CMR) can detect necrosis and edema with high spatial resolution and it can quantify dyssynchrony by tagging techniques. Patients with a first AMI underwent percutaneous coronary interventions (PCI) of the infarct-related artery within 24 h of onset of chest pain. Within 5-7 days after the event and at 4 months, CMR was performed. The CMR protocol included the evaluation of intraventricular dyssynchrony by applying a novel 3D-tagging sequence to the left ventricle (LV) yielding the CURE index (circumferential uniformity ratio estimate; 1 = complete synchrony). On T2-weighted images, edema was measured as high-signal (|2 SD above remote tissue) along the LV mid-myocardial circumference on 3 short-axis images (% of circumference
To the best of our knowledge, this is the first clinical report to analyze the urinary levels of biopyrrins in patients with HF. The present study provides clinical evidence that the urinary levels of biopyrrins/creatinine are changed in association with both NYHA functional class and plasma levels of BNP.. Recently, increases in plasma biochemical markers of oxidative stress have been reported in patients with HF (17,18). There is a definitive correlation between oxidative stress and ventricular dysfunction (2,4). Furthermore, ventricular remodeling and progressive dilation leading to end-stage HF may be mediated by oxygen-derived free radicals (2,4). Therefore, it is likely that ROS are involved in not only the pathogenesis but also the active progression of HF (3-6). In an attempt to prevent the production of oxidants, as well as to ameliorate and repair oxidative tissue damage, detoxification systems are present in vivo and comprise both enzymatic and nonenzymatic antioxidant compounds. ...
The Quintero Bay, located along the central Pacific coast of Chile, stands out due to its intense port and industrial activities, such as crude oil refining, thermoelectric generation, and mining. These activities occur close to urban areas and coexist with tourism, agriculture, aquaculture, and artisanal fishing. Since 2014, three major oil spills have occurred, generating a great social, ecological, and economic impact. This report describes the microbial community in seawater of two marine areas of the Quintero Bay through a 16S rRNA amplicon analysis.. Two seawater samples from the Quintero Bay were taken in autumn (23 May 2016) by a diver using sterile nuclease-free sampling bottles. Sample CGB1062-1 (10 m deep, 11°C) was taken near shipping docks (32°45′42″S, 71°29′44″W), while sample CGB1062-2 (10 m deep, 10°C) was sampled from the northwest area (32°44′05″S, 71°30′14″W). Samples were immediately preserved at 4°C for 1 h, and metagenomic DNA was extracted using a ...
PW spoke with author Isabel Quintero and illustrator Zeke Peña about their new picture book, My Papi Has a Motorcycle, and the power of memory.
The biggest cigar (50 ring gauge) in the Quintero brand with an affordable price. This cigar includes earty flavor and could be chosen for a gift.Presents with Cardboard Box of 25 cellophane bundled cigars.Vitola: Concha No.2Ring Gauge: 50Cigar ...
Left Ventricular Dysfunction - Market Insights, Epidemiology and Market Forecast - 2025 is a market research report available at US $5750 for a Single User PDF License from RnR Market Research Reports Library.
Methods and Results:. Pre-Fontan catheterisation data and Fontan pressure measured at the completion were retrospectively collected. Pre-Fontan data were used to calculate the predicted pressure in the Fontan system. The predicted values were compared to the Fontan pressure measured at the Fontan completion and with the needs for fenestration. One hundred twenty-four Fontan patients were retrospectively enrolled (At Fontan: median age 30.73 [24.70-37.20] months, median weight 12.00 [10.98-14.15] kg). Fontan conduit was fenestrated in 78 patients. A poor correlation (r2 = 0.05128) between the measured and predicted data for non-fenestrated patients was observed. In the case of Fontan-predicted pressure ,17.59 mmHg, the formula identified a good short-term clinical outcome with a sensitivity of 92%. ...
Dr. Calvin Weisberger answered: Diastolic dysfunctio: Good question....The heart in diastole relaxes and the fibers stretch out as t...
Arus Caralto, C., Nebot Sánchez, J., Coronel Linárez, I. E., Portas Ferreira Simoes, R. V., Valverde Saubí, D., Aguilera Grijalvo, C., Acebes Martin, J. J., Aparicio Caballero, A., Cabañas Egaña, M., Castañer Llanes, S., Cos Domingo, M., Godino Maritínez, O., Julià Sapé, M. M., Majós Torró, C., Mercadal Díaz, G., Quintero Bernabeu, M. R. & Serrallonga Mercader, M.. Ministerio de Educación y Ciencia. 13/12/05 → 13/12/08. Project ...
Left ventricular dysfunction is a major determinant of outcome in coronary artery disease.1 However, not all dyssynergic areas are irreversibly damaged after infarction, as left ventricular dysfunction may be caused by myocardial stunning2 or by chronic reduction of blood flow,3 and the segments involved may show improved function after restoration of blood flow.4 Preservation of metabolism despite reduced function is the cornerstone of viable myocardium, but ultrastructural changes have been documented in viable tissue, including loss of sarcoplasmic reticulum, small scattered mitochondria, and glycogen deposition.5 These changes suggest a reduction in aerobic metabolism, but glucose uptake and utilisation are preserved and indeed have been used as a diagnostic marker of viability.6. Because of co-morbidity, myocardial revascularisation may be difficult to achieve in many patients with left ventricular dysfunction and viable myocardium. In these situations, medical treatment to improve left ...
ARLINGTON -- Astros catcher Humberto Quintero had seen enough fowl play. It was taking too long, he said. Quintero was on deck in the ninth inning of Sundays game against the Rangers when a curious bird landed near home plate for the second time in a matter of minutes. Astros batter Chris Johnson tried to shoo it away with his bat and plate umpire Mike Reilly couldnt get it to budge, either. Thats when Quintero took over, approaching the bird and gently picking it up with both hands. He placed it in a camera well at the end of the first-base dugout, drawing cheers from the crowd. We have birds in Venezuela, said Quintero, who likes to hunt and was wearing batting gloves. Why were people scared? We have a lot of birds in Venezuela. I got it and put it away. I didnt want to wait 30 minutes for the bird to go away. Johnson was impressed with Quinteros bird-handling ability. It looked like hes done that before, Johnson said. Thats not something you see every day, so I was just trying ...
Septic myocardial dysfunction is a well recognised contributor to shock in sepsis but for many of us we assume this to be gross systolic impairment. Interestingly a recent study highlights that patients with severe sepsis and septic shock frequently have diastolic dysfunction1. They found that diastolic dysfunction was the strongest independent predictor of early mortality, even after adjusting for the APACHE-II score and other predictors of mortality.. In this study, 9.1% of severe sepsis/septic shock patients had isolated systolic dysfunction, 14.1% had combined systolic and diastolic dysfunction, and 38% had isolated diastolic dysfunction.. Importantly, the authors point out that although diastolic dysfunction is associated with age, hypertension, diabetes mellitus, and ischaemic heart disease, diastolic dysfunction is a stronger independent predictor of mortality than age and the other co-morbidities. However, a limitation of the study acknowledged by the authors is that it did not include ...
A common form of heart trouble called diastolic dysfunction appears to worsen over time and may lead to an increased risk of heart failure, new research shows.
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Read this chapter of Pharmacotherapy in Primary Care online now, exclusively on AccessPharmacy. AccessPharmacy is a subscription-based resource from McGraw Hill that features trusted pharmacy content from the best minds in the field.
Herein, we report the first large, population-based echocardiographic investigation of myocardial function among subjects with RA compared with non-RA subjects without a history of HF from the same community. We have shown that patients with RA have a higher prevalence of diastolic dysfunction (31%) than non-RA subjects (26%) based on currently accepted diagnostic criteria. Diastolic dysfunction was more common in RA than in the non-RA subjects even after adjustment for, or matching for, CV risk factors, although the associations were marginally significant. We have also found that diastolic dysfunction in RA is associated with RA duration and IL-6 level, even after adjustment for CV risk factors. Notably, the vast majority of subjects had preserved EF. The presence of diastolic dysfunction with preserved EF, or isolated diastolic dysfunction, has been previously associated with a marked increase in mortality in the general population.5 6 Hence, the increased prevalence of isolated diastolic ...
This page includes the following topics and synonyms: Systolic Dysfunction, Left Ventricular Dysfunction, Left Ventricular Failure, Systolic Heart Failure, Left Ventricular Systolic Dysfunction, Heart Failure with Reduced Ejection Fraction.
This St. Patricks Day, skip the green-tinged beer and instead drink to your health with this green smoothie created by Teresa Quintero, Wilcox Memorial Hospital clinical registered dietitian.. Smoothies can be an easy way to get more fruits and vegetables into your diet, says Quintero. They can be used as a snack, or they can replace a meal if youre in a rush so you dont skip it. They can even make for excellent recovery fuel post workouts.. Quintero came up with this green smoothie as a deliciously sneaky way to pack more calories and nutrients into her 7-year-olds diet.. This green smoothie is definitely kid approved! It is an excellent source of vitamins A and C, iron, and is a good source of calcium, she says.. But be careful with your ingredients, and watch those portions!. Quintero advises using a green, leafy vegetable - such as kale, spinach or lettuce - as your base and building on with fruits, nuts, seeds and other add-ons sparingly.. A low-fat, low-sugar milk alternative, ...
Maria Quintero is a provider established in Edinburg, Texas and her medical specialization is speech-language pathologist. The NPI number assigned to this provider is 1003001942.
Fingerprint Dive into the research topics of Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. Together they form a unique fingerprint. ...
Xenia Lovett, [email protected], x10217. Public Information Officer. Stephen Quintero, [email protected], x10238. 11824 Air Expressway Adelanto, CA 92301 Phone: (760) 246-8691. ...
Quartersnacks have re-edited a bunch of random seen and unseen footage of Zered Bassett this week featuring footage filmed by R.B. Umali, Joe Bouillot, Jason Jenkins, Steve Marino and Richard Quintero. Just think of it as a post-State of Mind part. Press play for Edit of the Week.. ...
Left ventricular diastolic dysfunction. *Valvular heart disease. *Congenital/acquired left heart inflow/outflow tract ... If it is caused by left heart disease, the treatment is to optimize left ventricular function by the use of medication or to ... Importantly, right ventricular remodeling is associated with increased apoptosis; this is in contrast to pulmonary vascular ... As such, the right ventricle cannot cope as well with higher pressures, and although right ventricular adaptations (hypertrophy ...
Right ventricular dysfunction is also common in HFpEF patients, occurring in 20-35% of patients. This right ventricular ... Left ventricular filling is dependent upon ventricular relaxation and compliance, mitral valve area, atrio-ventricular gradient ... Pulmonary hypertension and right ventricular dysfunction[edit]. Most HFpEF patients exhibit pulmonary hypertension which is ... A patient is said to have diastolic dysfunction if he has signs and symptoms of heart failure but the left ventricular ejection ...
Premature ventricular contractionEdit. Premature ventricular contraction causes early emptying of the left ventricle (LV) into ... Diastolic dysfunction - heart failureEdit. Diastolic dysfunction is associated with a reduced compliance, or increased ... The mechanism is of functional importance because it serves to adapt left ventricular output to right ventricular output.[3] If ... Since the next ventricular contraction occurs at its regular time, the filling time for the LV increases, causing an increased ...
In diastolic dysfunction, the end-diastolic ventricular pressure will be high. This increase in volume or pressure backs up to ... This type is also known as heart failure due to left ventricular systolic dysfunction or systolic heart failure. This type of ... Systolic dysfunction[edit]. Heart failure caused by systolic dysfunction is more readily recognized. It can be simplistically ... Diastolic dysfunction can be caused by processes similar to those that cause systolic dysfunction, particularly causes that ...
... in HIV-infected children reduces left ventricular dysfunction, increases left ventricular wall thickness, and reduces peak left ... In addition, patients with echocardiographic evidence of left ventricular dysfunction had a higher chance of having cardiac ... Many patients with HIV have nutritional deficiencies which have been linked to left ventricular dysfunction. HIV-infected ... Myocarditis and cardiotropic viral infection associated with severe left ventricular dysfunction in late-stage infection with ...
Braunwald E (1982). "The stunned myocardium: prolonged, postischemic ventricular dysfunction". Circulation. 66 (6): 1146-1149. ... Myocardial stunning or transient post-ischemic myocardial dysfunction is a state of mechanical cardiac dysfunction that can ... The area of dysfunction should also maintain normal perfusion, detected via Positron Emission Tomography, echocardiography with ... Some evidence supports the use of inotropic drugs in the case of severe myocardial dysfunction. Results from canine ...
Risk of severe CHF or left ventricular dysfunction, especially in patients with comorbidities ...
... after left ventricular dysfunction) ... sexual dysfunction, erectile dysfunction and/or alteration of ... "Vanderbilt Autonomic Dysfunction Center - Propranolol (Beta Blocker) - Vanderbilt Health Nashville, TN". ww2.mc.vanderbilt.edu ... "Vanderbilt Autonomic Dysfunction Center - Propranolol (Beta Blocker) - Vanderbilt Health Nashville, TN". ww2.mc.vanderbilt.edu ... The blockade of only beta receptors increases blood pressure, reduces coronary blood flow, left ventricular function, and ...
Dyke D, Koelling T (2008). "Heart failure due to left ventricular systolic dysfunction". In Eagle KA, Baliga RR (eds.). ... It is being studied for a potential role in the treatment of left ventricular systolic heart failure. Systolic heart failure ... Thus, the overall clinical result of omecamtiv mecarbil is an increase in left ventricular systolic ejection time and ejection ... leading to left ventricular hypertrophy, another characteristic of chronic heart failure. Current inotropic therapies work by ...
Dimensions Left ventricular systolic dysfunction; see Heart failure#Systolic dysfunction Ligonier Valley School District in ... LVSD may refer to: Left Ventricular end-systolic Dimension; see Ventricle (heart)# ...
Nyui N, Yamanaka O, Nakayama R, Sawano M, Kawai S (2000). "'Tako-Tsubo' transient ventricular dysfunction: a case report". Jpn ... 2002). "Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute ... Mid-ventricular obstruction, apical stunning: It has been suggested that a mid-ventricular wall thickening with outflow ... The theory of vasospasm is not easily separated from that of microvascular dysfunction and in fact, microvascular dysfunction ...
August 1993). "Activation of neurohumoral systems in postinfarction left ventricular dysfunction". Journal of the American ...
Heart failure (left ventricular systolic dysfunction). *Kidney complications of diabetes mellitus (diabetic nephropathy) ... It contributes to ventricular remodeling and ventricular hypertrophy of the heart through stimulation of the proto-oncogenes c- ... Patients with heart failure may benefit from the combination in terms of reducing morbidity and ventricular remodeling.[61][62] ... This leads to cardiac dysfunction and neuromuscular consequences, such as muscle weakness, paresthesia, nausea, diarrhea, and ...
... progressive right ventricular dysfunction, progressive tricuspid valve regurgitation, right ventricular systolic pressure above ... PPVI can be used to repair congenital defects in the pulmonary valve or right ventricular outflow tract dysfunction, such as ... "Percutaneous pulmonary valve implantation for right ventricular outflow tract dysfunction". NICE. NICE. Retrieved 25 March 2019 ... Ventricular function and size are assessed with an echocardiogram. The right ventricle and the anatomy of the outflow tract, ...
Cite journal requires ,journal= (help) Pollak, A; Falk, R H (1993-08-01). "Left ventricular systolic dysfunction precipitated ... Patients will demonstrate normal systolic function, diastolic dysfunction, and a restrictive filling pattern. 2-dimensional and ... In time, restrictive cardiomyopathy patients develop diastolic dysfunction and eventually heart failure.[citation needed] ... from restrictive cardiomyopathy will usually eventually have to be treated by cardiac transplantation or left ventricular ...
"Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting". ...
In diastolic dysfunction, the end-diastolic ventricular pressure will be high. This increase in volume or pressure backs up to ... Diastolic dysfunction can be caused by processes similar to those that cause systolic dysfunction, particularly causes that ... early-to-atrial left ventricular filling ratio), the E (early left ventricular filling) deceleration time, and the isovolumic ... The failure of ventricular relaxation also results in elevated end-diastolic pressures, and the end result is identical to the ...
Knorr, Andreas M. (1995). "Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?". The American Journal ...
"A noninvasive scintiphotographic method for detecting regional ventricular dysfunction in man." New England Journal of Medicine ... "A scintiphotographic method for measuring left ventricular ejection fraction in man without cardiac catheterization". The ...
McConnell MV, Solomon SD, Rayan ME, Come PC, Goldhaber SZ, Lee RT (August 1996). "Regional right ventricular dysfunction ... specificity for the diagnosis of acute pulmonary embolism in the setting of right ventricular dysfunction. Play media ... In massive and submassive PE, dysfunction of the right side of the heart may be seen on echocardiography, an indication that ... These include hypotension, cardiogenic shock, syncope, evidence of right heart dysfunction, and elevated cardiac enzymes. Some ...
CXCL9, -10, -11 have proven to be valid biomarkers for the development of heart failure and left ventricular dysfunction, ... "Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study". ...
... (also right ventricular strain or RV strain) is a medical finding of right ventricular dysfunction where the ... Right Ventricular Strain ECG Library Right Ventricular Strain & Failure Video by Vanderbilt Emergency Medicine McConnell sign ... "Transthoracic echocardiography in the evaluation of pediatric pulmonary hypertension and ventricular dysfunction". Pulmonary ...
"Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice". American Journal of Physiology. Heart and ...
Cardiovascular system damage can include myocardial ischemia/infarction, acute left ventricular dysfunction, acute pulmonary ... and subsequent dysfunction. After an acute event, this endothelial dysfunction has persisted for years[9]. ... with hypertensive crises often have chest pain as a result of this mismatch and may suffer from left ventricular dysfunction. ... The morbidity and mortality of hypertensive emergencies depend on the extent of end-organ dysfunction at the time of ...
Gatasko, Gavin I; Senior, Roxy; Lahiri, Avijit (2002). "A simple model to predict left ventricular systolic dysfunction in a ... "What is the most cost-effective strategy to screen for left ventricular systolic dysfunction: Natriuretic peptides, the ...
Cardiac involvement usually presents with evidence of left ventricular dysfunction and ECG changes; it occurs more often in ... Dysfunction of the kidney and liver are also suggested to promote this disorder in response to other drugs due to the ... or other organ dysfunctions. DRESS syndrome is one of several terms that have been used to describe a severe idiosyncratic ... and motor dysfunction due to meningitis or encephalitis. Rare manifestations of the disorder include inflammation of the ...
Co-occurring tricuspid regurgitation or right ventricular dysfunction can cause hepatomegaly to develop. There is no known ... On EKG, right axis deviation and right ventricular hypertrophy are common, but not indicative of HLHS. Chest x-ray may show a ...
The bronchoconstriction is also caused by left ventricular dysfunction, caused by the SRTXs. Left ventricular relaxation is ... This peribronchial edema is likely caused by impairment of left ventricular relaxation, elevating microvascular hydrostatic ...
Myocardial imaging usually demonstrates left ventricular dilation, severe ventricular dysfunction, and multiple infarctions. ... A 2004 study showed the patients in that study who underwent ventricular restoration as well as a coronary artery bypass ... "Results of Coronary Artery Bypass Grafting by a Single Surgeon Patients With Left Ventricular Ejection Fractions ≤30%". The ... "Coronary artery bypass with ventricular restoration is superior to coronary artery bypass alone in people with ischemic ...
Pitfalls in the diagnosis of ventricular shunt dysfunction: radiology reports and ventricular size. Pediatrics, 1998. 101: p. ... Emergency department evaluation of ventricular shunt malfunction: is the shunt series really necessary? Pediatr. Emerg. Care 23 ...
Dysfunction of lamin A triggers a DNA damage response and cellular senescence. DNA Repair (Amst.). 2006, 5 (2): 286-9. PMID ... ventricular cardiac muscle cell development. · cellular response to hypoxia. · positive regulation of cell aging. ...
... left ventricular dysfunction, or congestive heart failure.[37] Another skin condition, found in Europe but not in North America ... while echocardiography may show myocardial dysfunction.[37] Biopsy and confirmation of Borrelia cells in myocardial tissue may ...
Mitral valve dysfunction, congestive heart failure. Most severe. Common. Premature death. Stroke. Interrupted blood flow to the ... and ventricular hypertrophy. Kyphoscoliosis may worsen over time and contribute to these pathologies.[3] ... progression of reduced cardiac functioning over time may necessitate surgical procedures to counteract mitral valve dysfunction ...
This hemorrhage rarely extends into the ventricular system. Nontraumatic intraparenchymal hemorrhage most commonly results from ... leading to neurological dysfunction. Substantial displacement of brain parenchyma may cause elevation of intracranial pressure ... but it also may be due to autoregulatory dysfunction with excessive cerebral blood flow e.g.: - reperfusion injury - ...
McNaught KS, Jackson T, JnoBaptiste R, Kapustin A, Olanow CW (May 2006). "Proteasomal dysfunction in sporadic Parkinson's ... ventricular hypertrophy[132] and heart failure.[133] Additionally, evidence is accumulating that the UPS plays an essential ... "Ubiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathies". Circulation. 121 (8): 997-1004. doi ...
September 2003). "Oligodendrocyte dysfunction in schizophrenia and bipolar disorder". Lancet. 362 (9386): 798-805. doi:10.1016/ ... research now shows oligodendrocytes originate from the ventral ventricular zone of the embryonic spinal cord and possibly have ... Oligodendrocyte dysfunction may also be implicated in the pathophysiology of schizophrenia and bipolar disorder.[28] ...
IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and ... These diseases are characterized by chronic and progressive neuronal dysfunction, sometimes leading to behavioral abnormalities ...
Further, there are limited case reports supporting an association with cardiac dysfunction, and the frequently cited case- ... van Noord C, Dieleman JP, van Herpen G, Verhamme K, Sturkenboom MC (November 2010). "Domperidone and ventricular arrhythmia or ... Johannes CB, Varas-Lorenzo C, McQuay LJ, Midkiff KD, Fife D (September 2010). "Risk of serious ventricular arrhythmia and ... Leelakanok N, Holcombe A, Schweizer ML (2015). "Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic ...
... ventricular work load and ventricular radius. All of these reductions contribute to the decrease in ventricular wall stress ... Also Beta-receptor antagonists should be avoided in patients with AV node dysfunction and/or patients on other medications ...
Assessing the level of organic acids in urine can also indicate a dysfunction in the metabolic pathway.[6] ... In children with Leigh-syndrome associated ventricular septal defects, caused by pyruvate dehydrogenase deficiency, high ...
During ventricular systole, pressure rises in the left ventricle and when it is greater than the pressure in the aorta, the ... Valvular heart disease is a general term referring to dysfunction of the valves, and is primarily in two forms, either ... When ventricular systole ends, pressure in the left ventricle rapidly drops and the pressure in the aorta forces aortic valve ... At the end of ventricular systole, when the pressure in the right ventricle falls rapidly, the pressure in the pulmonary artery ...
"Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice". American Journal of Physiology. Heart and ...
There is no sensory neuropathy or autonomic or visceral dysfunction at presentation.[medical citation needed] ... Arrhythmogenic right ventricular dysplasia 9. *centrosome: PCNT (Microcephalic osteodysplastic primordial dwarfism type II) ...
... left ventricular size and function, peak right ventricular pressure (pulmonary hypertension), presence of left atrial thrombus ... Diastolic dysfunction is also associated with AF, which increases left atrial pressure, left atrial volume, size, and left ... Lower heart rates may be recommended in those with left ventricular hypertrophy or reduced left ventricular function.[110] Rate ... During AF, if all of the impulses from the atria passed through the AV node, there would be severe ventricular tachycardia, ...
As per other opioids, plus ventricular rhythm disorders. Levomethadone. Comes in hydrochloride salt form; soluble in water and ... Sedation, anticholinergic effects, weight gain, orthostatic hypotension, sinus tachycardia, sexual dysfunction, tremor, ... Severe pain (including labour pain); cough due to terminal lung cancer; angina; left ventricular failure.. As per codeine. ... Anticholinergic effects, GI effects, yawning, sweating, dizziness, weakness, sexual dysfunction, somnolence, insomnia, headache ...
... in which the cerebrospinal fluid is substituted with air to help an image form on an X-ray of the ventricular space in the ... more commonly referred to now as multiple organ dysfunction syndrome. They may also be admitted for intensive/invasive ...
Coagulation dysfunction is not a cause of EIPH, and anticoagulatory agents, including carbazochrome salicylate, aspirin, ... slow left ventricular relaxation time, right tricuspid valve regurgitation), preferential distribution of blood flow to the ... Horses that undergo surgical correction for upper airway dysfunction are rested, and are under environmentally controlled ...
End-organ dysfunction[edit]. Main article: Multiple organ dysfunction syndrome. Examples of end-organ dysfunction include the ... However, these agents may precipitate prolongation of the QT interval and consequently provoke a ventricular arrhythmia such as ... Multiple organ dysfunction syndrome. Other shock. Cardiogenic shock. Distributive shock. Anaphylaxis. Obstructive shock. ... Neurologic dysfunction *Glasgow Coma Score (GCS) ≤ 11, or. *altered mental status with drop in GCS of 3 or more points in a ...
... on gastrointestinal dysfunction and anorexia in combination with Western drug: a systematic review". Evidence-Based ... "Leptin: a novel link between obesity, diabetes, cardiovascular risk, and ventricular hypertrophy". Circulation. 108 (6): 644- ... "Taste and smell function in chronic disease:: A review of clinical and biochemical evaluations of taste and smell dysfunction ...
Note that there are types of activity that are statistically uncommon, but not associated with dysfunction or disease. These ... "EEG evidence for mirror neuron dysfunction in autism spectrum disorders". Cognitive Brain Research. 24 (2): 190-8. doi:10.1016/ ...
These lesions are concentrated around the basal ganglia, peri-ventricular white matter, and the pons, and are similar to those ... Peters, N (August 2008). "Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASIL". Journal of ...
... and endothelial dysfunction. In addition to NOS3, both NOS1 and NOS2 have been found to be S-nitrosated, but the evidence for ... "Neuronal nitric oxide synthase protects against myocardial infarction-induced ventricular arrhythmia and mortality in mice". ...
... with sustained sinus tachycardia reflects a larger infarct that are more anterior with prominent left ventricular dysfunction, ... If the heart rate is too high, cardiac output may fall due to the markedly reduced ventricular filling time. Rapid rates, ...
Prevalence Of Diastolic Dysfunction In Patients With Hypertension Referred For Echocardiographic Assessment of Left Ventricular ... Ultrasound is an excellent method for the study of the penis, such as indicated in trauma, priapism, erectile dysfunction or ... a measure of diastolic dysfunction). Contrast-enhanced ultrasound using gas-filled microbubble contrast media can be used to ...
"Taste and smell function in chronic disease:: A review of clinical and biochemical evaluations of taste and smell dysfunction ... "Leptin: a novel link between obesity, diabetes, cardiovascular risk, and ventricular hypertrophy". Circulation. 108 (6): 644- ... "Beneficial effects of rikkunshito, a Japanese kampo medicine, on gastrointestinal dysfunction and anorexia in combination with ...
Keating G, Plosker G (2004). "Eplerenone: a review of its use in left ventricular systolic dysfunction and heart failure after ... 2001). "Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the ... 1992). "Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial ... 2006). "Epidemiology of heart failure and left ventricular systolic dysfunction after acute myocardial infarction: prevalence, ...
... au QT hadi vipindi na matukio paroxsysmal ya tachycardia ventricular. Pathofisiolojia (sababu za kuugua mwilini) ya ... "fMRI measurement of brain dysfunction in alcohol-dependent young women". Alcohol. Clin. Exp. Res. 25 (2): 236-45. doi:10.1111/ ...
However, at present there is no consensus among scientists regarding whether or not ventricular enlargement, which is a poor ... Sexual dysfunction. Arousal. *Erectile dysfunction. *Female sexual arousal disorder. Desire. *Hypersexuality. *Hypoactive ...
Goldstein I, Meston CM, Davis S, Traish A (17 November 2005). Women's Sexual Function and Dysfunction: Study, Diagnosis and ... Feeding: a 2012 paper suggested that oxytocin neurons in the para-ventricular hypothalamus in the brain may play a key role in ...
... dysfunction are the most concerning and serious cardiovascular complications of cancer therapies and cause an increase in ... Cancer therapy-induced left ventricular dysfunction: interventions and prognosis. J Card Fail. 2014;20:155-8.CrossRefGoogle ... Novo G., Nugara C., Lancellotti P. (2019) Heart Failure and Left Ventricular Dysfunction. In: Russo A., Novo G., Lancellotti P ... Heart failure (HF) and left ventricular (LV) dysfunction are the most concerning and serious cardiovascular complications of ...
Right ventricle Systolic right ventricular dysfunction Diastolic right ventricular dysfunction Prevalence of right ventricular ... Thus, this chapter tries to elucidate some of the importance of the RV and its contribution to right ventricular dysfunction. ... Morvey D., Gupta S., Chandra A., von Schwarz E.R. (2018) Systolic and Diastolic Right Ventricular Dysfunction. In: Dumitrescu S ... Schwarz ER, Dashti R. The clinical quandary of left and right ventricular diastolic dysfunction and diastolic heart failure. ...
RECENT FINDINGS: There is growing evidence that right ventricular function is a key determinant in ... To evaluate new information on the importance of right ventricular function, diagnosis and management in cardiac surgical ... right ventricular failure will be influenced by the presence or absence of myocardial ischemia and left ventricular dysfunction ... 16645669 - Ventricular pseudoaneurysm associated with severe mitral regurgitation.. 23469039 - Troponin and anti-troponin ...
Right Ventricular Dysfunction in Asymptomatic Diabetic Patients. Wojciech Kosmala, Paolo Colonna, Monika Przewlocka-Kosmala, ... Right Ventricular Dysfunction in Asymptomatic Diabetic Patients. Wojciech Kosmala, Paolo Colonna, Monika Przewlocka-Kosmala, ... Right Ventricular Dysfunction in Asymptomatic Diabetic Patients Message Subject (Your Name) has forwarded a page to you from ... In clinical practice, right ventricular dysfunction is relevant in a variety of disease states affecting both the course and ...
Reviews and ratings for Enalapril when used in the treatment of left ventricular dysfunction. Share your experience with this ... Learn more about Left Ventricular Dysfunction. Symptom checker. *Chest Pain. Mayo Clinic Reference. *Left ventricular ... User Reviews for Enalapril to treat Left Ventricular Dysfunction. Also known as: Vasotec, Epaned ... His ventricular function has not deteriorated since starting enalapril 9 years ago and his cardiologist tells him to take this ...
... Marc A. Simon1,2 and Michael R. Pinsky1,2 ... Right ventricular (RV) dysfunction is the main cause of death in pulmonary arterial hypertension (PAH). Our understanding of ... N. Rajagopalan, M. A. Simon, M. A. Mathier, and A. Lopez-Candales, "Identifying right ventricular dysfunction with tissue ... 4. Identifying RV Dysfunction. Identifying RV dysfunction at less severe stages, which would allow for earlier intervention and ...
Right Ventricular Dysfunction in Asymptomatic Diabetic Patients. Wojciech Kosmala, Paolo Colonna, Monika Przewlocka-Kosmala, ... Right Ventricular Dysfunction in Asymptomatic Diabetic Patients. Wojciech Kosmala, Paolo Colonna, Monika Przewlocka-Kosmala, ... not only left ventricular but also right ventricular function is impaired and 2) the deterioration of right ventricular ... Right Ventricular Dysfunction in Asymptomatic Diabetic Patients Message Subject (Your Name) has forwarded a page to you from ...
Reversible left ventricular systolic dysfunction: reversibility of coronary microvascular abnormality. Jpn Heart J. 2001; 42: ... The clinical impact of reversal of the left ventricular dysfunction seen with brain death4,5 may hold great promise for ... Tako-Tsubo-Like Left Ventricular Dysfunction. Junya Ako, Yasuhiro Honda, Peter J. Fitzgerald ... Reversible left ventricular dysfunction associated with raised troponin I after subarachnoid haemorrhage does not preclude ...
Prevalence of Asymptomatic Ventricular Dysfunction. The safety and scientific validity of this study is the responsibility of ... A population-based assessment of left ventricular systolic dysfunction in middle-aged and older adults: the Strong Heart Study ... Chronic congestive heart failure (CHF), caused by left ventricular dysfunction (LVD), is a major cause of morbidity and ... Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic ...
Reviews and ratings for lotensin when used in the treatment of left ventricular dysfunction. Share your experience with this ... Learn more about Left Ventricular Dysfunction. Symptom checker. *Chest Pain. Mayo Clinic Reference. *Left ventricular ... Left Ventricular Dysfunction carvedilol, metoprolol, Coreg, benazepril, valsartan, More.... Heart Failure amlodipine, ... Reviews for Lotensin to treat Left Ventricular Dysfunction. No reviews have yet been submitted. Be the first to review this ...
This topic contains 8 study abstracts on Left Ventricular Dysfunction indicating that the following substances may be helpful: ... Diseases : Left Ventricular Dysfunction, Left Ventricular Hypertrophy. Pharmacological Actions : Cardiovascular Agents, Matrix ... Diseases : Left Ventricular Dysfunction, Myocardial Infarction, Stem Cell Transplant. Therapeutic Actions : Stem Cell ... Diseases : Cardiac Mortality , Left Ventricular Dysfunction, Mortality: All-Cause, Myocardial Infarction. Additional Keywords ...
... Line Lisbeth Olesen1 and Thomas Vauvert F. ... "Upregulation of Soluble HLA-G in Chronic Left Ventricular Systolic Dysfunction," Journal of Immunology Research, vol. 2016, ...
Measurement of BNP could be a cost-effective method of screening for left-ventricular systolic dysfunction in the general ... We took a left-ventricular ejection fraction of 30% or less to show left-ventricular systolic dysfunction. NT-ANP and BNP were ... Biochemical detection of left-ventricular systolic dysfunction Lancet. 1998 Jan 3;351(9095):9-13. doi: 10.1016/s0140-6736(97) ... Background: In previous studies on the use of natriuretic peptides to detect left-ventricular systolic dysfunction, a higher ...
An echocardiogram (below left) showed severe left ventricular impairment (ejection fraction , 20%). ...
Right ventricular failure, defined as the inability to deliver sufficient blood flow thro ... This review summarizes the approach to and recent developments in the treatment of acute right ventricular dysfunction and ... Right ventricular dysfunction may cause venous congestion and systemic hypoperfusion. After identifying right ventricular ... The failure of the right ventricle is caused by reduced right ventricular contractility or an increased right ventricular ...
... had mild ventricular dysfunction (ejection fraction 41% to 54%), and 4% had severe ventricular dysfunction (ejection fraction ≤ ... Patients with severe ventricular dysfunction were older than those with mild dysfunction or normal function (mean, 58 versus 54 ... Those with severe ventricular dysfunction, compared with those with mild dysfunction or normal ejection fraction, had greater ... Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults. The HyperGEN Study. Richard B. Devereux, ...
Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults. The HyperGEN Study. Richard B. Devereux, ... Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults. Richard B. Devereux, Jonathan N. Bella, ... Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults. Richard B. Devereux, Jonathan N. Bella, ...
Myocardial Infarction and Transient Ventricular Dysfunction in an Adolescent With Sickle Cell Disease. Andreas J. Deymann and ... Myocardial Infarction and Transient Ventricular Dysfunction in an Adolescent With Sickle Cell Disease ... Myocardial Infarction and Transient Ventricular Dysfunction in an Adolescent With Sickle Cell Disease ... Myocardial Infarction and Transient Ventricular Dysfunction in an Adolescent With Sickle Cell Disease ...
Thirty to fifty percent of patients presenting with signs and symptoms of heart failure have a normal left ventricular (LV) ... Left ventricular diastolic dysfunction and diastolic heart failure Annu Rev Med. 2004;55:373-94. doi: 10.1146/annurev.med. ... The first is to reverse the consequences of diastolic dysfunction (e.g., venous congestion), and the second is to eliminate or ... Thirty to fifty percent of patients presenting with signs and symptoms of heart failure have a normal left ventricular (LV) ...
"Ventricular Dysfunction, Left" by people in Harvard Catalyst Profiles by year, and whether "Ventricular Dysfunction, Left" was ... "Ventricular Dysfunction, Left" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Ventricular Dysfunction, Left" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Ventricular Dysfunction, Left". ...
NATRIURETIC PEPTIDES IN ASSESSMENT OF VENTRICULAR DYSFUNCTION. Maksimiljan Gorenjak, MSc. Department for Laboratory Diagnostics ... Although echocardiography is considered the gold standard for the detection of left ventricular dysfunction, it is expensive. ... NP determination is a useful addition to the standard clinical investigation of patient with ventricular dysfunction. During ... Little NP is produced by ventricular tissue in normal adults, but it is present in ventricular tissue of fetuses and neonates ...
Abstract 17865: Right Ventricular Diastolic Dysfunction in ABCG2 knockout mice under Hypoxia. Bence Nagy, Chandran Nagaraj, ... Introduction: Right ventricular (RV) hypertrophy followed by RV dysfunction is the main cause of mortality in pulmonary ... Abstract 17865: Right Ventricular Diastolic Dysfunction in ABCG2 knockout mice under Hypoxia ... Abstract 17865: Right Ventricular Diastolic Dysfunction in ABCG2 knockout mice under Hypoxia ...
... after exercise can identify early left ventricular dysfunction in asymptomatic patients with moderate-severe aortic stenosis. ... in peak systolic mitral annular velocity after treadmill exercise is a marker of early left ventricular systolic dysfunction. ... Objective: To determine whether longitudinal left ventricular systolic function measured by Doppler tissue imaging (DTI) ... and left ventricular ejection fraction ,50% and 15 aged-matched normal controls. ...
The prevalence (or prior probability) of left ventricular systolic dysfunction in this study was 32%; this is consistent with ... Likelihood ratios for screening tests for left ventricular systolic dysfunction. Any combination of tests is defined as being ... Concentrations of the peptide were raised in the 40 patients with left ventricular systolic dysfunction (median concentration ... Biochemical detection of left-ventricular systolic dysfunction. Lancet 1998; 351: 9-13. ...
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. ... dP/dt indicates the rate of left ventricular contraction; -dP/dt, the rate of left ventricular relaxation; -DOB, the baseline ... PLN ablation prevented not only cardiac dysfunction and ventricular dilation, but also the profound histopathological ... is a critical determinant of left ventricular function in vivo (22), and neither ventricular morphometry nor wall stress was ...
PubMed journal article Contribution of left ventricular diastolic dysfunction to heart failure regardless of ejection fractio ... In HF with an ejection fraction ,/=0.40, systolic dysfunction and left ventricular dilation accompany diastolic dysfunction. SN ... In HF with an ejection fraction ,/=0.40, systolic dysfunction and left ventricular dilation accompany diastolic dysfunction. ... Contribution of Left Ventricular Diastolic Dysfunction to Heart Failure Regardless of Ejection Fraction. Am J Cardiol. 2005 Mar ...
0.45 and their predictive value for left ventricular systolic dysfunction.. Results: 15 patients (12%) had left ventricular ... Value of the electrocardiogram in identifying heart failure due to left ventricular systolic dysfunction. BMJ 1996;312: 222-225 ... Cohort study of plasma natriuretic peptides for identifying left ventricular systolic dysfunction in primary care. BMJ 1998;317 ... The prevalence of left ventricular systolic dysfunction was 12%(nine men and six women). Table 2 describes these 15 patients. ...
... deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during ... deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during ... deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction ... In contrast to WT mice, Hif2alpha(+/-) mice were fully protected against pulmonary hypertension and right ventricular ...
Left atrial dysfunction relates to symptom onset in patients with heart failure and preserved left ventricular ejection ... Left ventricular strain rate showed no differences between non-HF and HFPEF groups, but both groups showed differences with the ... In outpatients with new-onset symptoms of HF, LA dysfunction was observed. It might be the initial mechanism in the development ... These findings support the relationship of LA dysfunction with HFPEF, suggesting that the analysis of LA function may be useful ...
Pre-existing left ventricular systolic dysfunction (left ventricular ejection fraction , 50%). *Pre-existing atrial ... Left ventricular dysfunction [ Time Frame: At the time of screening ]. Left ventricular systolic function ... Opportunistic Screening for Asymptomatic Left Ventricular Dysfunction in Coronavirus Disease 2019 (COVID19) Survivors. The ... Opportunistic Screening for Asymptomatic Left Ventricular Dysfunction in COVID-19 Survivors. Estimated Study Start Date :. ...
  • We took a left-ventricular ejection fraction of 30% or less to show left-ventricular systolic dysfunction. (nih.gov)
  • With the addition of echocardiographic variables, lower ejection fraction was associated with male gender, black race, prior myocardial infarction, and higher ventricular mass and lower relative wall thickness, pulse pressure, and body mass index. (ahajournals.org)
  • Thirty to fifty percent of patients presenting with signs and symptoms of heart failure have a normal left ventricular (LV) systolic ejection fraction. (nih.gov)
  • Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall. (harvard.edu)
  • Heart failure (HF) has been classified as systolic and diastolic based on the left ventricular ejection fraction. (unboundmedicine.com)
  • We hypothesized that left ventricular diastolic dysfunction is an important element of HF regardless of ejection fraction. (unboundmedicine.com)
  • Thus, regardless of ejection fraction, patients who have HF also have diastolic dysfunction. (unboundmedicine.com)
  • Diastolic dysfunction is a better predictor of B-type natriuretic peptide levels and mortality than ejection fraction or left ventricular EDVI. (unboundmedicine.com)
  • 0.05) related to ejection fraction 0.45 and their predictive value for left ventricular systolic dysfunction. (bmj.com)
  • Left atrial dysfunction relates to symptom onset in patients with heart failure and preserved left ventricular ejection fraction. (nih.gov)
  • Left ventricular ejection fraction, stroke work, and maximum rate of pressure change decreased comparably in both groups as a function of time on ECMO. (diva-portal.org)
  • Reduced LV ejection fraction and stroke work indicated LV dysfunction during ECMO. (diva-portal.org)
  • Left ventricular ejection fraction (LVEF) at rest was normal in 18 patients and abnormal in 5. (annals.org)
  • Plasma BNP levels also increase with decreasing physiological functional capacities, as measured by left ventricular ejection fraction (LVEF) or exercise-based evaluations [9]. (thefreelibrary.com)
  • Conventional echocardiography predictors of poor outcome, such as left ventricular (LV) ejection fraction (EF) and restrictive filling pattern have recently been supplemented by tissue Doppler imaging (TDI). (thefreelibrary.com)
  • In patients with heart failure (HF) symptoms, echocardiography often reveals a low left ventricular ejection fraction (LVEF). (thefreelibrary.com)
  • In particular, both users and non-users showed increased wall thickness and relative wall thickness compared with controls, whereas left ventricular ejection fraction, left ventricular end-diastolic diameter and transmitral Doppler indexes were comparable for the three groups. (bmj.com)
  • Traditionally, LV systolic function has been expressed in terms of left ventricular ejection fraction (LVEF), referring to the fraction of LV end-diastolic volume ejected during systole. (onlinejacc.org)
  • Liu S, Guan Z, Jin X, Meng P, Wang Y, Zheng X, Jia D, Ma C, Yang J. Left ventricular diastolic and systolic dyssynchrony and dysfunction in heart failure with preserved ejection fraction and a narrow QRS complex. (medsci.org)
  • Seventy-eighty patients with a narrow QRS complex including 47 with HFpEF, 31 with heart failure with reduced ejection fraction (HFrEF) patients, and 29 with asymptomatic left ventricular diastolic dysfunction (LVDD) were recruited. (medsci.org)
  • Pulmonary artery pressure rises, impeding right ventricular ejection, and the right heart dilates. (renalandurologynews.com)
  • 1 ) report an increased prevalence of left ventricular (LV) systolic dysfunction among patients with rheumatoid disease in comparison to the general population based on a visual estimate of echocardiographic LV ejection fraction. (onlinejacc.org)
  • Left ventricular (LV) global longitudinal strain (GLS) is an echocardiographic measure of LV systolic function that can be an indicator of early subclinical cardiac dysfunction, even when LV ejection fraction is normal. (columbia.edu)
  • In the derivation cohort, Cox regression models were constructed including cardiotoxic cancer treatment exposures with and without ejection fraction to estimate the probability developing left-ventricular dysfunction with an ejection fraction less than 40% (LVD40) at 10-year follow-up. (ascopost.com)
  • Left-ventricular ejection fraction was measurable in 1467 (89·5%) participants by the biplane Simpson's rate method. (gla.ac.uk)
  • BACKGROUND: Microvascular obstruction (MO) is associated with large acute myocardial infarction and lower left ventricular (LV) ejection fraction and predicts greater remodeling, but whether this effect is abolished by contemporary antiremodeling therapies is subject to debate. (druglib.com)
  • BACKGROUND: Cardiac contractility modulation (CCM) is a treatment option for patients suffering symptomatic chronic heart failure (CHF) with reduced left ventricular ejection fraction (LVEF) who are not eligible for cardiac resynchronization. (minervamedica.it)
  • Left ventricular functional parameters (systolic: LV ejection fraction (EF), heart rate (HR) vs. diastolic: peak filling rate (PFR)) were obtained using an automatic ventricular edge detection software. (uni-wuerzburg.de)
  • RVS pacing induced a major ventricular dyssynchrony, severe left ventricular ejection fraction deterioration and symptoms of congestive heart failure. (springermedizin.de)
  • Upgrading to a biventricular device was associated with a decrease in the symptoms and ventricular dyssynchrony, and increased left ventricular ejection fraction (LVEF). (springermedizin.de)
  • Echocardiographic examination two days after pacemaker implantation demonstrated a normal LV function (55%), a LV end-diastolic volume (LVEDV) of 84 mL, the absence of significant valvulopathy and an aortic pre-ejection period (PEP) of 160 ms. A ventricular dyssynchrony (80 ms between septal and lateral electromechanical delays) was also measured with tissue Doppler imaging (TDI). (springermedizin.de)
  • Subclinical left ventricular (LV) dysfunction refers to subtle abnormalities in LV function which typically precede a reduction in the left ventricular ejection fraction (LVEF). (eurekaselect.com)
  • Echocardiograms measured left ventricular internal dimension during diastole and systole, left ventricular posterior wall thickness during diastole, interventricular septum thickness during diastole, left ventricular ejection fraction and diastolic filling. (biomedcentral.com)
  • Left ventricular ejection fraction was below 55% in 29 cyclists. (biomedcentral.com)
  • This relates to impaired ventricular contractility and a defective ability of the myofibrils to shorten against a load with a consequent decrease in ejection fraction. (alpfmedical.info)
  • Diastolic dysfunction occurs despite a relatively normal ejection fraction and ventricular size. (alpfmedical.info)
  • Thus, the overall clinical result of omecamtiv mecarbil is an increase in left ventricular systolic ejection time and ejection fraction. (wikipedia.org)
  • The objective of the present study was to assess right ventricular systolic and diastolic function using conventional echocardiography and tissue Doppler imaging (TDI) in diabetic patients without coronary artery disease and with and without coexisting hypertension. (diabetesjournals.org)
  • Temporal changes in left ventricular systolic function in heart donors: results of serial echocardiography. (ahajournals.org)
  • Subjects undergo echocardiography to measure ventricular function parameters, as well as a clinical assessment of symptoms, signs and risk factors for LVD. (clinicaltrials.gov)
  • In the study,1012 primary care patients with hypertension and/or diabetes without signs or symptoms of heart failure were screened for asymptomatic left ventricular dysfunction (ALVD), using measurements of NT-pro-BNP and echocardiography. (scienceblog.com)
  • The full study is "The Role of N-Terminal PRO-Brain Natriuretic Peptide and Echocardiography for Screening Asymptomatic Left Ventricular Dysfunction in a Population at High Risk for Heart Failure: The PROBE-HF Study" by Irene Betti, Gabriele Castelli, Alessandro Barchielli, Cinzia Beligni, Vittorio Boscherini, Leonardo De Luca, Gianni Messeri, Mihai Gheorghiade, Alan Maisel, and Alfredo Zuppiroli. (scienceblog.com)
  • To assess the probability of left ventricular systolic dysfunction without echocardiography in patients from general practice. (bmj.com)
  • Cross sectional study using multivariate regression models to examine the relation between clinical variables and left ventricular systolic dysfunction as determined by echocardiography. (bmj.com)
  • 1 - 5 About 3% of the adult population have systolic dysfunction, 6 - 8 but half of them are asymptomatic and can be identified only by objective methods, usually echocardiography. (bmj.com)
  • The purpose of the study was to examine how primary care doctors might identify patients at increased risk of systolic dysfunction in order to decide who to refer for echocardiography. (bmj.com)
  • in this regard, echocardiography may be useful in confirming diastolic dysfunction [13]. (thefreelibrary.com)
  • Animals were dosed with doxorubicin (20 mg/kg i.p.), and left ventricular performance was assessed in vivo using M-mode and Doppler echocardiography. (aspetjournals.org)
  • The goal of this study was to examine the association of serum γ-glutamyltransferase (GGT) levels with left ventricular (LV) diastolic dysfunction and LV hypertrophy.Methods and Results:A cross-sectional study of 79,459 Korean men and women who underwent an echocardiography as part of a comprehensive health examination between March 2011 and December 2014. (physiciansweekly.com)
  • The presence of LV diastolic dysfunction and LV hypertrophy was determined using echocardiography. (physiciansweekly.com)
  • 934 Measurement of basal ventricular asynchrony by real-time 3D long axis echocardiography Chung, R. (ebscohost.com)
  • An abstract of the article "Measurement of basal ventricular asynchrony by real-time 3D long axis echocardiography," by R. Chung, W. Li, and M. Y. Henein is presented. (ebscohost.com)
  • Doppler echocardiography (D-E) is an essential tool in the assessment of patients with LV dysfunction, not only because it allows noninvasive quantitation of severity, pulmonary pressures, and functional mitral regurgitation (FMR), but also provides indirect measures of diastolic function. (onlinejacc.org)
  • This case series suggests that milrinone may be a useful therapy for premature infants with echocardiography findings of PH and/or RH dysfunction. (ovid.com)
  • In a cross-sectional survey of 2000 men and women aged 25-74, randomly sampled from one geographical area, we assessed left- ventricular systolic function by echocardiography. (gla.ac.uk)
  • Subclinical left ventricular dysfunction, 2-dimensional speckle tracking echocardiography, Global longitudinal strain. (eurekaselect.com)
  • Prasad Gunasekaran, Sidakpal Panaich, Alexandros Briasoulis, Shaun Cardozo and Luis Afonso, "Incremental Value of Two Dimensional Speckle Tracking Echocardiography in the Functional Assessment and Characterization of Subclinical Left Ventricular Dysfunction", Current Cardiology Reviews (2017) 13: 32. (eurekaselect.com)
  • Imaging techniques such as echocardiography, ventriculography, and nuclear imaging can be used to detect a contractile dysfunction following reperfusion after an episode of ischemia. (wikipedia.org)
  • The area of dysfunction should also maintain normal perfusion, detected via Positron Emission Tomography, echocardiography with contrast, and/or thallium scintigraphy in order for a diagnosis of myocardial stunning to be considered. (wikipedia.org)
  • A normal LVEF response during exercise was shown in only 5 of the patients with normal resting left ventricular function. (annals.org)
  • Children who had undergone BAV for AVS and LV dysfunction within the age range of six to 192 months showed a significant reduction in peak-to-peak pressure gradient (PPG) from 73.5 ± 30 mmHg to 26.7 ± 6.7 mmHg and improvement in LVEF from 32.8 ± 11% to 54.3 ± 12.7% after 24 hours. (cureus.com)
  • This study is designed to compare left ventricular diastolic function among patients divided by brachial-ankle pulse wave velocity (baPWV) and corrected P wave dispersion (PWDC) and assess whether the combination of baPWV and PWDC can predict LVDD more accurately. (medsci.org)
  • The χ ² test was used to compare the left ventricular diastolic function between the CI and non‑CI groups. (spandidos-publications.com)
  • Although studies have suggested that the decline of LVD function is a transfer from a physiological to a pathological process and that an early manifestation of hypertension in heart damage is the reduction of diastolic function ( 12 ), there have been no clinical reports on the association between LVD dysfunction and CI among young patients with hypertension, to the best of our knowledge. (spandidos-publications.com)
  • 389 Right ventricular diastolic function abnormalities in patients with type 1 diabetes. (ebscohost.com)
  • An abstract of the study "Right Ventricular Diastolic Function Abnormalities in Patients With Type 1 Diabetes," by D. Beldekos and colleagues is presented. (ebscohost.com)
  • Left ventricular diastolic dysfunction (LVDD) has long been considered as the main cause of HFpEF, however, large previous clinical trials failed to improve the prognosis of HFpEF by restoring LV diastolic function[ 3 , 4 , 5 ]. (medsci.org)
  • In this research, an extension to our previous work published in the Clinical Journal of Sports Medicine in 2009, we studied subjects that differed in terms of age and training status and assessed the impact of prolonged exercise on systolic and left ventricular diastolic function and cardiac biomarkers levels, recognized as identifiers of cardiac damage and dysfunction. (biomedcentral.com)
  • We also assessed the possible influence of event duration, exercise intensity and weight loss (dehydration) on left ventricular diastolic function. (biomedcentral.com)
  • The decrease in left ventricular systolic and diastolic function did not correlate with age, training status, race duration, weight loss or exercise intensity. (biomedcentral.com)
  • Left ventricular systolic and diastolic function was reduced and cardiac biomarkers were increased after the cycling event, but the mechanisms behind such outcomes remain unclear. (biomedcentral.com)
  • Specific exercise parameters (training status and exercise intensity and duration) that may affect observed changes in biomarkers and ventricular systolic and diastolic function are poorly described and the mechanisms involved are not well understood. (biomedcentral.com)
  • The DMHT group exhibited significantly higher systolic and diastolic blood pressure, higher prevalence of left ventricular hypertrophy, and more prescriptions for antihypertensive (ACE inhibitors, β-blockers, Ca antagonists, and diuretics) and lipid-lowering (statins and fibrates) drugs. (diabetesjournals.org)
  • To conduct a population-based study of the prevalence of asymptomatic ventricular dysfunction. (clinicaltrials.gov)
  • However, available estimates of LVD prevalence are based on symptomatic patients, not on objectively measured ventricular function parameters. (clinicaltrials.gov)
  • 8,9 Furthermore, few data are available on the combined prevalence of symptomatic and asymptomatic LV systolic dysfunction in population samples, 6 especially of high-risk groups such as blacks. (ahajournals.org)
  • 10 With the development of echocardiographic methods that provide a high yield of quantitative LV measurements, it has become possible to determine the prevalence and correlates of LV systolic dysfunction in population-based samples of hypertensive patients. (ahajournals.org)
  • Accordingly, the present study was undertaken to assess the prevalence and clinical and echocardiographic correlates of mild and severe LV systolic dysfunction in hypertensive black and white women and men participating in the Hypertension Genetic Epidemiology Network (HyperGEN) Study. (ahajournals.org)
  • To measure the prevalence of, and factors associated with, left ventricular (LV) dysfunction in systemic sclerosis (SSc). (bmj.com)
  • To estimate the prevalence of pulmonary artery hypertension (PAH) and right ventricular (RV) dysfunction in COPD patients in the Kirov region of Russia. (ersjournals.com)
  • Our study confirmed high prevalence of PAH and RV dysfunction in COPD patients in the Kirov region of Russia. (ersjournals.com)
  • 394 Prevalence of isolated diastolic dysfunction in hospitalized diabetic patients: correlations according to different line treatment. (ebscohost.com)
  • An abstract of the study "Prevalence of Isolated Diastolic Dysfunction in Hospitalized Diabetic Patients: Correlations According to Different Line Treatment," by G. Pumilia and colleagues is presented. (ebscohost.com)
  • Thus the higher prevalence of LV systolic dysfunction among patients with rheumatoid disease is somewhat difficult to reconcile with these two observations. (onlinejacc.org)
  • Toyono M, Harada K, Tamura M, Yamamoto F, Takada G. Myocardial acceleration during isovolumic contraction as a new index of right ventricular contractile function and its relation to pulmonary regurgitation in patients after repair of tetralogy of Fallot. (springer.com)
  • PURPOSE OF REVIEW: To evaluate new information on the importance of right ventricular function, diagnosis and management in cardiac surgical patients. (biomedsearch.com)
  • RECENT FINDINGS: There is growing evidence that right ventricular function is a key determinant in survival in cardiac surgery, particularly in patients with pulmonary hypertension. (biomedsearch.com)
  • In clinical practice, right ventricular dysfunction is relevant in a variety of disease states affecting both the course and prognosis (12-16), and therefore one may assume that right ventricular performance is also an important issue in diabetic patients. (diabetesjournals.org)
  • The clinical impact of reversal of the left ventricular dysfunction seen with brain death 4,5 may hold great promise for patients awaiting a donor heart. (ahajournals.org)
  • Left ventricular wall motion abnormalities in patients with subarachnoid hemorrhage: neurogenic stunned myocardium. (ahajournals.org)
  • It is important to recognize that recovery of left ventricular function may occur in patients who have suffered sudden cardiac death and whose hearts may be suitable for transplantation. (ahajournals.org)
  • Equally important is the appreciation of the transient nature of left ventricular systolic dysfunction in patients suffering from acute myocardial infarction and undergoing successful reperfusion. (ahajournals.org)
  • In these patients, recovery of left ventricular function after days or weeks may prevent the need for implantation of defibrillators or chronic therapy for severe left ventricular systolic dysfunction. (ahajournals.org)
  • A combination of carnitine, CoQ10 and taurine repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. (greenmedinfo.com)
  • Hawthorn (Crataegus) reduces the incidence of sudden cardiac death in patients with less compromised left ventricular function. (greenmedinfo.com)
  • Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. (greenmedinfo.com)
  • Moderate coffee consumption lowers the likelihood of developing left ventricular systolic dysfunction in post-acute coronary syndrome normotensive patients. (greenmedinfo.com)
  • Omega-3 fatty acid reduce the total mortality and sudden death in patients with left ventricular systolic dysfunction. (greenmedinfo.com)
  • The intracoronary injection of selected CD133(+) stem cells is secure and feasible in patients with left ventricle dysfunction following acute myocardial infarction. (greenmedinfo.com)
  • Philadelphia, PA 11 June 2009 - The value and cost-effectiveness of screening for left ventricular (LV) dysfunction remains unclear, particularly since specific, evidence-based treatments are not available for the majority of patients with preserved systolic dysfunction, reports a study in the June issue of the Journal of Cardiac Failure ( http://www.onlinejcf.com ), published by Elsevier. (scienceblog.com)
  • This study suggests that the evaluation of NT-proBNP in asymptomatic patients with type 2 diabetes or hypertension may lead to very early exclusion of LV dysfunction. (scienceblog.com)
  • In a population-based sample of hypertensive patients, left ventricular systolic dysfunction was related to male gender, black race, diabetes, and elevated uric acid levels, as well as higher ventricular mass and lower relative wall thickness. (ahajournals.org)
  • Olsen FJ, Christensen LM, Krieger DW, Højberg S, Høst N, Karlsen FM, Svendsen JH, Christensen H, Biering-Sørensen T. Relationship between left atrial strain, diastolic dysfunction and subclinical atrial fibrillation in patients with cryptogenic stroke: the SURPRISE echo substudy. (harvard.edu)
  • To determine whether longitudinal left ventricular systolic function measured by Doppler tissue imaging (DTI) after exercise can identify early left ventricular dysfunction in asymptomatic patients with moderate-severe aortic stenosis. (bmj.com)
  • In asymptomatic patients with moderate-severe aortic stenosis a lower than normal increase in peak systolic mitral annular velocity after treadmill exercise is a marker of early left ventricular systolic dysfunction. (bmj.com)
  • 1 Patients usually present to their general practitioner but a definitive diagnosis of left ventricular systolic dysfunction can only be achieved by cardiac imaging. (bmj.com)
  • 15 patients (12%) had left ventricular systolic dysfunction. (bmj.com)
  • Only one of 60 patients with a normal electrocardiogram had systolic dysfunction (2%, 95% confidence interval 0% to 9%) regardless of response to the other two questions. (bmj.com)
  • Identification and treatment of patients with left ventricular systolic dysfunction improves survival and reduces morbidity. (bmj.com)
  • These findings support the relationship of LA dysfunction with HFPEF, suggesting that the analysis of LA function may be useful in sinus rhythm patients with new-onset dyspnoea. (nih.gov)
  • Third ventricular width was retained in most stepwise regression analyses predicting cognitive impairment in patients with MS and distinguishing secondary progressive from relapsing-remitting courses of MS. CONCLUSIONS: We confirm an association between neocortical volume and multiple cognitive domains in MS, although neocortical volume did not explain significantly more variance than other magnetic resonance imaging measures. (omicsonline.org)
  • We conducted a double-blind, placebo-controlled study evaluating the effect of eplerenone, a selective aldosterone blocker, on morbidity and mortality among patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure. (unboundmedicine.com)
  • The addition of eplerenone to optimal medical therapy reduces morbidity and mortality among patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure. (unboundmedicine.com)
  • Background】Left ventricular diastolic dysfunction lead to left atrial stasis and thus increases a risk of left atrial appendage thrombus in patients with atrial fibrillation. (medworm.com)
  • We investigated whether left ventricular diastolic dysfunction is associated with embolic burden in patients with ischem ic stroke related to atrial fibrillation. (medworm.com)
  • Coronary Microvascular Dysfunction, Left Ventricular Remodeling and Clinical Outcomes in Patients with Chronic Kidney Impairment. (medworm.com)
  • 34 (22.7%) patients had a grade 1 left ventricular diastolic dysfunction. (ersjournals.com)
  • 17 (13%) patients had left ventricular hypertrophy. (ersjournals.com)
  • Our findings demonstrate that left ventricular diastolic dysfunction frequently occurs in patients with OSA and that it is related to the severity of oxygen desaturation. (ersjournals.com)
  • In patients with heart failure and pulmonary hypertension, RV strain detected RV dysfunction when conventional CCUS measurements were preserved. (rug.nl)
  • RV strain seems to have an added value for detecting RV dysfunction when conventional measurements of RV function are preserved, especially in patients with underlying cardiac pathologies. (rug.nl)
  • Exercise radionuclide angiography was used to assess the incidence of subclinical abnormalities of left ventricular function in 23 asymptomatic patients with thalassemia major. (annals.org)
  • During exercise a normal ventricular response was shown in 4 patients. (annals.org)
  • After 1 year of intensive chelation therapy in these 12 patients, left ventricular function was reassessed. (annals.org)
  • Patients with pulmonary embolism and right ventricle dysfunction (determined with clinical, hemodynamic or echocardiographic methods) are a subgroup at high risk for complications. (revespcardiol.org)
  • Screening patients by means of baPWV and PWDC might help identify the high risk group of elevated left ventricular filling pressure and LVDD. (medsci.org)
  • Incidence of atrial fibrillation in patients with either heart failure or acute myocardial infarction and left ventricular dysfunction: a cohort study. (sigmaaldrich.com)
  • We examined the incidence of new-onset atrial fibrillation in patients with left ventricular dysfunction. (sigmaaldrich.com)
  • In patients with left ventricular dysfunction the incidence of AF in 42 months was 9.6% in patients with heart failure and 2.9% in patients with a recent MI. (sigmaaldrich.com)
  • NT-proBNP levels, as predictor of left ventricular systolic and diastolic dysfunction in patients with chronic heart failure. (thefreelibrary.com)
  • Levels of BNP have been shown to be elevated in patients with cardiac dysfunction [4, 5]. (thefreelibrary.com)
  • We describe the cases of three patients with well-documented severe left ventricular dysfunction due to doxorubicin who had complete clinical recovery with return of cardiac function to normal. (annals.org)
  • Enalapril and carvedilol for preventing chemotherapy-induced left ventricular systolic dysfunction in patients with malignant hemopathies: the OVERCOME trial (preventiOn of left Ventricular dysfunction with Enalapril and caRvedilol in patients submitted to intensive ChemOtherapy for the treatment of Malignant hEmopathies). (sigmaaldrich.com)
  • This study sought to evaluate the efficacy of enalapril and carvedilol to prevent chemotherapy-induced left ventricular systolic dysfunction (LVSD) in patients with hematological malignancies. (sigmaaldrich.com)
  • Catheter-directed therapy (CDT) for pulmonary embolism (PE) is considered as an alternative to systemic thrombolysis (ST) in patients with hemodynamically unstable acute PE who are considered at high bleeding risk for ST. We aimed to evaluate the efficacy and safety of CDT in the management of acute PE with right ventricular dysfunction (RVD). (medscimonit.com)
  • Right ventricular (RV) remodeling and dysfunction were revealed in all COPD patients with PAH. (ersjournals.com)
  • Diastolic RV dysfunction was detected in 100% and systolic RV dysfunction - in 12.8% of those cases (56 patients). (ersjournals.com)
  • Moreover, the presence of a small LV cavity, the reliability and automation of the global longitudinal strain (GLS) signal, and the independent prognostic role of GLS are reasons why GLS could be expected to be a better marker of subclinical LV dysfunction in these patients. (onlinejacc.org)
  • Predictive value of microvolt T-wave alternans in patients with left ventricular dysfunction. (harvard.edu)
  • However, the association between CI and left ventricular diastolic (LVD) dysfunction in young patients with hypertension has rarely been reported. (spandidos-publications.com)
  • The purpose of the present study was to investigate the association between LVD dysfunction and acute CI in young patients with hypertension. (spandidos-publications.com)
  • Recent studies have indicated that left ventricular diastolic (LVD) dysfunction may occur in hypertensive patients when their heart structure is still normal ( 3 ). (spandidos-publications.com)
  • Left atrium, left ventricular configuration and functional changes have been associated with acute CI in patients with hypertension or coronary heart disease ( 4 ). (spandidos-publications.com)
  • A study by Shimizu et al ( 7 ) determined a positive correlation between LVD dysfunction and cerebral white matter lesions in elderly patients. (spandidos-publications.com)
  • Background We attempted to test the hypothesis that chronic angiotensin II type 1A receptor blockade (ARB) alters myocardial collagen turnover leading to an improvement of diastolic dysfunction in diabetic patients. (go.jp)
  • Conclusions Chronic ARB improves diastolic dysfunction in diabetic patients, at least partially through the attenuation of myocardial fibrosis, by regulating collagen turnover, particularly by facilitating collagen degradation. (go.jp)
  • 356 Clinical characteristics of patients referred with suspected heart failure and preserved left ventricular systolic function. (ebscohost.com)
  • An abstract of the study "Clinical characteristics of patients referred with suspected heart failure and preserved left ventricular systolic function," by C. Constantin and colleagues is presented. (ebscohost.com)
  • 112 Heart failure with preserved and depressed left ventricular systolic function: features and prognosis in a multicenter registry of 4720 patients. (ebscohost.com)
  • An abstract of the study "The Effect of Diuretics on Peak Oxygen Consumption and Quality of Life in Patients With Compensated Left Ventricular Dysfunction," by S. Gupta and colleagues is presented. (ebscohost.com)
  • Magnetically guided left ventricular lead implantation in CRT patients. (ebscohost.com)
  • An abstract of the article "Magnetically guided left ventricular lead implantation in CRT patients," by M. Taborsky and colleagues is presented. (ebscohost.com)
  • 417 First step towards the definition of a multidisciplinary tool for guidance to work eligibility in patients with left ventricular dysfunction. (ebscohost.com)
  • An abstract of the article "First Step Towards the Definition of a Multidisciplinary Tool for Guidance to Work Eligibility in Patients With Left Ventricular Dysfunction," by S. De Feo and colleagues, is presented. (ebscohost.com)
  • 274 A marker of early ventricular dysfunction in rheumatoid arthritis patients. (ebscohost.com)
  • An abstract of the study "A marker of early ventricular dysfunction in rheumatoid arthritis patients," by S. Abou-Raya and colleagues is presented. (ebscohost.com)
  • The aim of the present study was to measure regional ventricular function at rest and during stress in order to assess if patients with Type II diabetes have subclinical myocardial dysfunction and if it is related to risk factors. (clinsci.org)
  • Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. (acpjc.org)
  • To determine the effectiveness of d -sotalol for reducing all-cause mortality in patients with previous myocardial infarction (MI) and left ventricular (LV) dysfunction. (acpjc.org)
  • d -sotalol was associated with greater all-cause and cardiac mortality than was placebo in patients with previous myocardial infarction and left ventricular dysfunction. (acpjc.org)
  • The risk for death among patients who have an MI is increased by LV dysfunction, frequent or repetitive ventricular premature depolarizations (VPDs), and extent of residual ischemia ( 1 ). (acpjc.org)
  • Apart from β-blockers, no antiarrhythmic drug is indicated except for use in patients who have survived sustained ventricular tachycardia or ventricular fibrillation. (acpjc.org)
  • Great interest attends the publication of the recently presented evidence that amiodarone reduced the rate of arrhythmic deaths in patients who survived MI and had frequent or repetitive VPDs and LV dysfunction in the Canadian Amiodarone Myocardial Infarction Arrhythmia Trial ( 4 ) and the European Myocardial Infarct Amiodarone Trial ( 5 ). (acpjc.org)
  • Prevalences of previous myocardial infarction are comparable in the patients and general population, and previous myocardial infarction is strongly related to LV systolic dysfunction among patients with rheumatoid disease. (onlinejacc.org)
  • Objectives The aim of the study is to clarify the clinical role of Doppler-echocardiographic parameters of left ventricular diastolic dysfunction (LVDD) as determinants of pulmonary hypertension in patients experiencing left ventricular systolic dysfunction (LVSD) with and without the presence of functional mitral valve regurgitation (FMR). (onlinejacc.org)
  • Myocardial viability assessment is typically reserved for patients with coronary artery disease and significant left ventricular dysfunction. (onlinejacc.org)
  • The present research evaluated the progression of left ventricular structural and functional changes in children and adolescent patients with type I DM and the effect of glycemic control on these changes. (scialert.net)
  • Patients were divided into 2 groups: group composed of 46 patients with type I DM and left ventricular hypertrophy (LVH+ve group) compared to another group, composed of 89 patients with type I DM but had a normal left ventricular echocardiographic parameters (LVH -ve group). (scialert.net)
  • Echocardiographic follow-up was done thoroughly again for patients who had left ventricular hypertrophy (LVH) after two years. (scialert.net)
  • Also comparing echocardiographic parameters of those patients who achieved glycemic control to their baseline results showed that mean value of interventricular septal dimension (IVSd) decreased from 1.12cm to 1.03 (p = 0.04), posterior wall dimension (PWd) decreased from 1.07-0.97 (p = 0.05) however diastolic dysfunction represented by isovolumic relaxation time (IVRT) and E/A did not show a statistically significant change. (scialert.net)
  • Microvascular obstruction remains a portent of adverse remodeling in optimally treated patients with left ventricular systolic dysfunction after acute myocardial infarction. (druglib.com)
  • The aim of this study is to assess the impact of CCM on quality of life, symptoms, exercise tolerance and left ventricular function in patients with CHF and moderate-to- severe left ventricular systolic dysfunction. (minervamedica.it)
  • Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. (semanticscholar.org)
  • Cardiac injury, including left ventricular dysfunction, frequently occurs in patients with subarachnoid hemorrhage. (semanticscholar.org)
  • Left ventricular dysfunction of the anterior and anteroseptal walls that spares the apex is unusual for patients with myocardial infarction and may represent a neurally mediated pattern of injury. (semanticscholar.org)
  • Therapy for these patients include anticongestive medications and, in some, placement of devices such as aortic balloon pump or left ventricular assist device (LVAD), or cardiac transplantation. (eurekaselect.com)
  • We investigated whether right ventricular dysfunction (RVD) as assessed by echocardiogram can be used as a prognostic factor in hemodynamically stable patients with acute pulmonary embolism (PE). (springermedizin.de)
  • Among 3283 hemodynamically stable patients with acute PE, 1223 patients (37.3%) had RVD, as assessed by echocardiogram, while 2060 patients (62.7%) had normal right ventricular function. (springermedizin.de)
  • Sanchez O, Trinquart L, Colombet I, Durieux P, Huisman MV, Chatellier G, Meyer G: Prognostic value of right ventricular dysfunction in patients with haemodynamically stable pulmonary embolism: a systematic review. (springermedizin.de)
  • This is a randomised controlled trial comparing a course (35 sessions over 4 to 7 weeks) of standard (one hour) versus brief (5 minutes) sessions of EECP in patients with ischaemic heart disease and left ventricular systolic dysfunction to determined whether there is a difference between these interventions. (isrctn.com)
  • The response to standard failure therapy is generally worse in patients with predominant diastolic dysfunction. (alpfmedical.info)
  • Cardiac dysfunction is now a major cause of death in patients with Duchenne muscular dystrophy (DMD), and that the dystrophin genotype probably does not predict the course of the cardiomyopathy. (bmj.com)
  • The literature on right ventricular systolic dysfunction (RVSD) in peripartum cardiomyopathy (PPCM) patients is scanty, and it appears that RV reverse remodelling in PPCM has not been previously described. (biomedcentral.com)
  • We previously described right ventricular (RV) systolic dysfunction in PPCM patients using tricuspid annular plane systolic excursion (TAPSE), and reported RV systolic dysfunction (RVSD) in 54.6 % of the patients [ 3 ]. (biomedcentral.com)
  • Elevated plasma CCN2 levels are associated with RV dysfunction and valvular regurgitation in NET patients. (biomedcentral.com)
  • Left ventricular (LV) dysfunction in patients with aortic valve stenosis (AVS) is seen in two scenarios: in neonates and in elderly patients. (cureus.com)
  • of these, 41 (25.6%) patients had LV dysfunction. (cureus.com)
  • Four patients died, all of whom had severe LV dysfunction - one died during the procedure and three died within six to 20 hours after successful BAV. (cureus.com)
  • Patients with AVS who develop LV dysfunction deteriorate and die soon without treatment. (cureus.com)
  • To investigate the potential underlying left ventricular myocardial dysfunction after chronic misuse of AAS in athletes by use of Doppler myocardial imaging (DMI) and strain rate imaging (SRI). (bmj.com)
  • Early and accurate recognition of myocardial dysfunction offers the potential to optimize the timing of intervention in severe AS. (onlinejacc.org)
  • BACKGROUND: The mechanism of myocardial dysfunction in the remote, noninfarct-related regions is an unresolved issue to date. (kuleuven.be)
  • CONCLUSIONS: Remote myocardial dysfunction contributes significantly to the loss in global ventricular function. (kuleuven.be)
  • Myocardial stunning or transient post-ischemic myocardial dysfunction is a state of mechanical cardiac dysfunction that can occur in a portion of myocardium without necrosis after a brief interruption in perfusion, despite the timely restoration of normal coronary blood flow. (wikipedia.org)
  • Some evidence supports the use of inotropic drugs in the case of severe myocardial dysfunction. (wikipedia.org)
  • Heart failure (HF) and left ventricular (LV) dysfunction are the most concerning and serious cardiovascular complications of cancer therapies and cause an increase in morbidity and mortality. (springer.com)
  • Schwarz ER, Dashti R. The clinical quandary of left and right ventricular diastolic dysfunction and diastolic heart failure. (springer.com)
  • Chronic congestive heart failure (CHF), caused by left ventricular dysfunction (LVD), is a major cause of morbidity and mortality. (clinicaltrials.gov)
  • Left ventricular dysfunction is the most common cause of congestive heart failure. (marketresearch.com)
  • Chronic hypoxia induces pulmonary vascular remodeling, leading to pulmonary hypertension, right ventricular hypertrophy, and heart failure. (nih.gov)
  • It is uncertain whether COVID-19 survivors are at risk cardiac dysfunction including cardiac arrhythmia and heart failure. (clinicaltrials.gov)
  • The outcome measures include (1) new onset cardiac arrhythmia, (2) N Terminal (NT)-proBNP elevation above the diagnostic range of heart failure, and (3) newly detected left ventricular dysfunction. (clinicaltrials.gov)
  • The primary end points were death from any cause and death from cardiovascular causes or hospitalization for heart failure, acute myocardial infarction, stroke, or ventricular arrhythmia. (unboundmedicine.com)
  • PBI-4050 Reduces Pulmonary Hypertension, Lung fibrosis and Right Ventricular Dysfunction in Heart Failure. (annals.org)
  • Chronic heart failure (CHF) is currently recognized as a clinical syndrome occurring not only as a result of rnechanical dysfunction of the ventricles, but also due to complex molecular, endocrine, neuroendocrine, and inflammatory changes [3] Neurohormonal activation plays a fundamental role in the onset and progression of heart failure and the use of biochemical markers as prognostic indicators in heart failure have expanded in the last decade. (thefreelibrary.com)
  • Plasma BNP levels provide clinically useful information concerning the diagnosis and management of left ventricular dysfunction and heart failure, which complements other diagnostic testing procedures (e.g., electrocardiograms, chest x-rays, and echocardiograms) [6,7]. (thefreelibrary.com)
  • Because inflammation contributes to the symptoms of heart failure, we determined the circulating levels of three related chemokines, CXCL-9, -10 and -11, as well as NT-proBNP in serum from subjects with left ventricular dysfunction (LVD) and controls. (ovid.com)
  • 334 The ECG in diagnosis of heart failure (HF) due to left ventricular systolic dysfunction (LVSD) � Is advice from guidelines flawed? (ebscohost.com)
  • 509 Therapy with Vagus nerve electrical stimulation combined with beta-blockade improves left ventricular systolic function in dogs with heart failure beyond that seen with beta-blockade alone. (ebscohost.com)
  • Left ventricular systolic dysfunction (LVSD) is a major factor in the development of symptomatic congestive heart failure. (onlinejacc.org)
  • However, an important landmark in the progression from uncomplicated left ventricular (LV) dysfunction to congestive heart failure is the development of pulmonary venous or mixed pulmonary venous/arterial pulmonary hypertension (PH). (onlinejacc.org)
  • Clinical heart failure may ensue secondary to pump dysfunction and arrhythmias, causing significant morbidity and mortality. (onlinejacc.org)
  • Interpretation Left-ventricular systolic dysfunction was at least twice as common as symptomatic heart failure defined by clinical criteria. (gla.ac.uk)
  • In cases of LV dysfunction, a significant percentage of affected individuals develop signs and symptoms of congestive heart failure (CHF), leading to the need for therapeutic intervention. (eurekaselect.com)
  • In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). (uni-wuerzburg.de)
  • ECG-gated \(^{18}\)F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). (uni-wuerzburg.de)
  • To date it is not known whether diffuse interstitial myocardial fibrosis is present before the onset of heart failure symptoms or changes in conventional parameters of left ventricular function. (biomedcentral.com)
  • It is being studied for a potential role in the treatment of left ventricular systolic heart failure. (wikipedia.org)
  • This causes peripheral edema (blood pooling), which the sympathetic nervous system tries to correct by overstimulating the cardiac myocytes, leading to left ventricular hypertrophy, another characteristic of chronic heart failure. (wikipedia.org)
  • Lemarié J, Huttin O, Girerd N, Mandry D, Juillière Y, Moulin F, Lemoine S, Beaumont M, Marie PY, Selton-Suty C. Usefulness of speckle-tracking imaging for right ventricular assessment after acute myocardial infarction: a magnetic resonance imaging/echocardiographic comparison within the relation between aldosterone and cardiac remodeling after myocardial infarction study. (springer.com)
  • In that regard, international consensus guidelines on the echocardiographic assessment of right ventricular function have been recently published. (biomedsearch.com)
  • SUMMARY: The use of right ventricular pressure monitoring and the publications of guidelines for the echocardiographic assessment of right ventricular anatomy and function allow the early identification of right ventricular failure. (biomedsearch.com)
  • A normal electrocardiogram implies a low risk of left ventricular systolic dysfunction. (bmj.com)
  • Abstract BACKGROUND: Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results. (omicsonline.org)
  • An abstract of the paper "Right Ventricular Dysfunction Predicts Clinical Outcomes Following Cardiac Resynchronization," by Francisco Alpendurada and colleagues is presented. (ebscohost.com)
  • abstract = "study objective: To assess the natural history of isolated left ventricular diastolic dysfunction. (elsevier.com)
  • 25 mm Hg with a pulmonary capillary wedge pressure, left atrial pressure, or left ventricular end-diastolic pressure ≤15 mm Hg [ 9 ]. (hindawi.com)
  • We investigated the effectiveness of plasma N-terminal atrial natriuretic peptide (NT-ANP) and brain natriuretic peptide (BNP) concentrations to show left-ventricular systolic dysfunction in a random sample of the general population. (nih.gov)
  • PADN attenuated RV dysfunction, marked with reduced atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and ratio of right ventricular to left ventricular plus septum weight [RV/(LV + S)]. Moreover, the local RAAS expression was activated in PAH dogs while inhibited after PADN. (biomedcentral.com)
  • Right ventricular function and failure. (springer.com)
  • The right ventricular function in cardiovascular disease, part II. (springer.com)
  • Ryan JJ, Tedford R. Diagnosing and treating the right ventricular function in cardiovascular disease. (springer.com)
  • Right ventricular function in cardiovascular disease, part I. Anatomy, physiology, aging, and functional assessment of the right ventricle. (springer.com)
  • His ventricular function has not deteriorated since starting enalapril 9 years ago and his cardiologist tells him to take this medication religiously. (drugs.com)
  • and TDI to assess right and left ventricular longitudinal myocardial function in the basal and mid-segments. (diabetesjournals.org)
  • The distributions of ventricular function parameters in the United States population are unknown. (clinicaltrials.gov)
  • This is a population-based study of the distribution of ventricular function parameters in 2,050 adult residents of Olmsted County, MN and, in collaboration with the Strong Heart study, in 1,522 adult Northern Plains American Indians. (clinicaltrials.gov)
  • and that abnormal left ventricular structure/function and brain natriuretic peptide are associated with incident clinical events. (clinicaltrials.gov)
  • Curcumin improves left ventricular function in pressure overloaded rabbits. (greenmedinfo.com)
  • and (3) examine associations of LV systolic dysfunction with measures of LV geometry and valvular function. (ahajournals.org)
  • Poudel K, Shah AM, Michos ED, Folsom AR, Konety S, Lutsey PL. Association of serum calcium and phosphorus with measures of left ventricular structure and function: The ARIC study. (harvard.edu)
  • The current study addresses the role of ABCG2 transporter in the right ventricular function in the well established hypoxia-induced PH murine model. (ahajournals.org)
  • 0.001) with preserved systolic- and left ventricular function. (ahajournals.org)
  • There are some reports on negative effects of VA-ECMO on cardiac function, such as left ventricular (LV) dilatation and cardiac stun, but the support in the literature is scarce. (diva-portal.org)
  • Coronary microvascular dysfunction (CMD) has been proposed as a link between abnormal renal function and impairment of cardiac function and CV events. (medworm.com)
  • Regional left ventricular (LV) function has not been systematically studied in ARVD. (scialert.net)
  • In conclusion, hypertension in the young is associated with decreased LVD function and is a risk factor for diastolic dysfunction of the left ventricle. (spandidos-publications.com)
  • We sought to assess left ventricular (LV) dyssynchrony and function in HFpEF and elucidate the underlying mechanisms that may account for HFpEF. (medsci.org)
  • Acute right heart syndromes are caused when pulmonary vascular resistance increases beyond the capacity of right ventricular function, most often seen with pulmonary embolism or ARDS or following cardiac surgery. (renalandurologynews.com)
  • It has been known for close to half a century that left ventricular (LV) function is of prognostic significance in cardiovascular disease. (onlinejacc.org)
  • Investigating a diabetic rat model, ECG-gated \(^{18}\)F-FDG PET imaging detected LV diastolic dysfunction while systolic function was still preserved. (uni-wuerzburg.de)
  • Magnetic resonance tagging provided information on the regional ventricular morphology and function. (kuleuven.be)
  • We report the case of a 55-year-old Tunisian woman with preserved ventricular function, implanted with a dual-chamber pacemaker for complete atrioventricular block. (springermedizin.de)
  • All subjects underwent cardiac MRI (1.5 T) to assess ventricular function, diffuse interstitial myocardial fibrosis by measurement of extracellular volume on T1-mapping (MOLLI) and coarse replacement fibrosis using standard late gadolinium enhancement imaging. (biomedcentral.com)
  • Diffuse interstitial myocardial fibrosis is common in Alström syndrome and is associated with impaired left ventricular systolic function. (biomedcentral.com)
  • 1) to establish whether diffuse interstitial myocardial fibrosis is present in asymptomatic adult subjects with ALMS, 2) if present, determine whether this is associated with change in left ventricular function. (biomedcentral.com)
  • 1. Improvement in left ventricular function and coronary perfusion reserve based on assessment by gadolinium-enhanced rest/stress (adenosine) cine CMR. (isrctn.com)
  • 2. To confirm the hypothesis that the degree of improvement in left ventricular function is affected by the extent of viable myocardium. (isrctn.com)
  • Echocardiograph results indicated that left ventricular diastolic and systolic function decreased after the race, with systolic function reduced to a significant degree. (biomedcentral.com)
  • To the best of our knowledge, the influence of exercise intensity on left ventricular function has not yet been determined, as we were unable to locate any studies of ventricular dysfunction in cyclists of different ages and training levels for a long-duration cycling event (6 hours or more). (biomedcentral.com)
  • Therefore, for a long-duration cycling test, we studied, following a similar study [ 19 ], the influence of age, level of training, exercise intensity, event duration and weight loss (dehydration) on ventricular function and their association with cardiac biomarkers. (biomedcentral.com)
  • Fig. 2 Effect of progressive reductions in ventricular compliance on ventricular function curves. (alpfmedical.info)
  • However, impaired right ventricular (RV) function due to fibrosis of the mural wall could potentially be an earlier manifestation of CHD. (biomedcentral.com)
  • Therefore, the aim of this study was to evaluate outcomes to establish the safety and effectiveness of BAV in children with AVS and LV dysfunction in improving LV function and survival. (cureus.com)
  • Our data suggest that BAV in children with aortic stenosis and LV dysfunction is safe and effective in the normalization of LV function. (cureus.com)
  • Additionally, the Report highlights the frontrunners, the drivers and barriers for the Left Ventricular Dysfunction market, as well as treatment algorithm, current treatments & advancements are included.The chapters including marketed products highlights the advantages and disadvantages associated with therapies associated with Left Ventricular Dysfunction , providing an in-depth analysis of emerging therapies which will create an impact through their launch. (rnrmarketresearch.com)
  • We sought to investigate the relationships between CKD, CMD, cardiac dysfunction and adverse CV outcomes. (medworm.com)
  • NT-proBNP levels also rise more gradually for a given level of cardiac dysfunction. (thefreelibrary.com)
  • NT-proBNP appears to be a more discerning marker of early cardiac dysfunction than BNP [20-21]. (thefreelibrary.com)
  • These data demonstrate that alteration of cardiac nitric oxide control and attendant peroxynitrite formation may be an important contributor to doxorubicin-induced cardiac dysfunction. (aspetjournals.org)
  • Thus, although the clinical importance of DOX-related cardiac dysfunction and toxicity is widely recognized, the precise cellular events involved have not been established, and optimal therapeutic approaches for cardioprotection are not fully defined. (aspetjournals.org)
  • Cardiac dysfunction consequently leads to a cascade of molecular events to maintain physiological equilibrium. (onlinejacc.org)
  • A challenging clinical scenario remains: the patient with severe cardiac dysfunction receiving optimal medical therapy (OMT) and carrying significant surgical risk. (onlinejacc.org)
  • We will review the pathophysiological events in ischemic cardiac dysfunction, noninvasive strategies to image viable myocardium, and the current published reports regarding patient outcomes with decisions aided by viability testing. (onlinejacc.org)
  • One of the pathogenic factors of right ventricular dysfunction in pulmonary embolism is myocardial ischemia, usually secondary to hemodynamic overload, and sometimes worsened by underlying coronary artery disease. (revespcardiol.org)
  • We described a patient with pulmonary embolism and dyskinesia of the right ventricular free wall, related to chronic atherosclerotic occlusion of the right coronary artery proximal to the acute marginal branches that irrigate the free wall. (revespcardiol.org)
  • Coutance G, Cauderlier E, Ehtisham J, Hamon M: The prognostic value of markers of right ventricular dysfunction in pulmonary embolism: a meta-analysis. (springermedizin.de)
  • Methods to better diagnose RV dysfunction earlier and treatments specifically designed to minimize or reverse the remodeling process are likely to improve outcomes. (hindawi.com)
  • PURPOSE: Research over the last decade with imaging methods showed that right ventricular (RV) intramyocardial fat (MF) deposition was found in „normal“ heart, as age-related process, after myocardial infarction and in pathophysiological condition as arrhythmogenic right ventricular. (ebscohost.com)
  • The present study examined the relationships between respiratory parameters and left ventricular abnormalities in OSA. (ersjournals.com)
  • Despite the substantial differences in the EF, Both groups have reductions in exercise tolerance, neurohumoral activation, and abnormal left ventricular (LV) filling dynamics and impaired relaxation and have similar clinical symptoms and signs. (thefreelibrary.com)
  • Some cancer treatments induce left ventricular dysfunction that appears early after exposure and therefore may adversely affect oncological therapy, while others generate cardiac injuries resulting in clinical problems only years later. (springer.com)
  • Pathophysiology, clinical importance and mangement of right ventricular failures. (springer.com)
  • Dysfunction of the right ventricle (RV) can occur in a number of clinical scenarios including pressure overload, cardiomyopathies, ischemic, congenital, or valvular heart disease, arrhythmias, and sepsis. (hindawi.com)
  • 2,3,6,7 However, the proportion of cases of clinical CHF that are due to left ventricular (LV) systolic dysfunction compared with LV diastolic dysfunction, valvular heart disease, or other causes is not well established. (ahajournals.org)
  • Right ventricular (RV) dysfunction is common in the critically ill and associated with adverse clinical outcomes. (rug.nl)
  • Right ventricular dysfunction predicts clinical outcomes following cardiac resynchronization. (ebscohost.com)
  • In clinical series, the frequency of PH is variable, but its development is associated with an augmented mortality/morbidity beyond that of LV dysfunction alone ( 1-4 ). (onlinejacc.org)
  • Medical and surgical treatment of acute right ventricular failure. (springer.com)
  • PURPOSE OF REVIEW: This review summarizes the approach to and recent developments in the treatment of acute right ventricular dysfunction and failure in the perioperative setting. (biomedsearch.com)
  • Measurement of BNP could be a cost-effective method of screening for left-ventricular systolic dysfunction in the general population, especially if its use were targeted to individuals at high risk. (nih.gov)
  • As noted by the investigators, the current International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) guidelines recommend performance of echocardiograms once every 5 years to facilitate early detection and treatment of asymptomatic left-ventricular dysfunction in all childhood cancer survivors who received cardiotoxic cancer therapies. (ascopost.com)
  • Diastolic dysfunction was found in 368 subjects (36%) and was categorized as mild in 327 and moderate-severe in 41. (scienceblog.com)
  • This may partly lead to an elevated RVEDP causing more severe diastolic dysfunction. (ahajournals.org)
  • Left ventricular (LV) systolic dysfunction is an adverse consequence of the pressure overload of severe aortic stenosis (AS). (onlinejacc.org)
  • The aim of this study was to investigate the association between left ventricular diastolic dysfunction (LVDD) and erectile dysfunction (ED) without overt cardiovascular disease. (physiciansweekly.com)
  • The association between increased arterial stiffness and left ventricular diastolic dysfunction (LVDD) may be influenced by left ventricular performance. (medsci.org)
  • P wave dispersion is not only a significant determinant of left ventricular performance, but is also correlated with LVDD. (medsci.org)
  • In that regard, the role of left ventricular diastolic dysfunction (LVDD) remains to be clarified. (onlinejacc.org)
  • The failure of the right ventricle is caused by reduced right ventricular contractility or an increased right ventricular afterload or both. (biomedsearch.com)
  • After identifying right ventricular dysfunction, the primary goal is to correct reversible causes of excessive load or reduced right-ventricular contractility. (biomedsearch.com)
  • Inhaled nitric oxide and inhaled prostaglandin E1: effect on left ventricular contractility when used for treatment of experimental pulmonary hypertension. (semanticscholar.org)
  • Cardiac adverse effects influenced by diabetes have been demonstrated thus far for the left ventricle, particularly systolic and diastolic dysfunction identified at rest (1-9) and/or during exercise (10-11). (diabetesjournals.org)
  • Right ventricular (RV) dysfunction is the main cause of death in pulmonary arterial hypertension (PAH). (hindawi.com)
  • Right ventricular (RV) hypertrophy followed by RV dysfunction is the main cause of mortality in pulmonary hypertension (PH). (ahajournals.org)
  • Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during pr. (nih.gov)
  • In contrast to WT mice, Hif2alpha(+/-) mice were fully protected against pulmonary hypertension and right ventricular hypertrophy, unveiling a critical role of HIF-2alpha in hypoxia-induced pulmonary vascular remodeling. (nih.gov)
  • 947 Mean longitudinal strain and strain rate: an index of assessing subclinical left ventricular dysfunction in hypertension Pavlopoulos, H. (ebscohost.com)
  • Milrinone has been proposed as an effective treatment for pulmonary hypertension (PH) and right ventricular (RV) dysfunction. (ovid.com)
  • 0·001), but there was no difference between those with and without left-ventricular systolic dysfunction in the rate of hypertension without IHD. (gla.ac.uk)
  • The transthoracic echocardiogram showed the presence of three auricular thrombus, right ventricular dysfunction and pulmonary hypertension. (scielo.org.mx)
  • Left ventricular dysfunction with pulmonary hypertension: part 2: prognosis, noninvasive evaluation, treatment, and future research. (semanticscholar.org)
  • This review seeks to define whether the existing EF cutoff in AS should be modified or whether GLS should replace it as the marker of subclinical LV dysfunction. (onlinejacc.org)
  • The association of BP control with early subclinical LV dysfunction according to GLS has not been extensively studied, and it is also unknown whether assessing BP control with ambulatory blood pressure (ABP) monitoring is superior to using office BP measurements in this regard. (columbia.edu)
  • This article highlights the incremental utility of 2D-STE in the detection of subclinical LV dysfunction. (eurekaselect.com)
  • Reversible left ventricular systolic dysfunction: reversibility of coronary microvascular abnormality. (ahajournals.org)
  • For some, specific therapy may be life-saving, as in thrombolysis for acute pulmonary thromboembolism or percutaneous coronary intervention for acute right ventricular infarction. (renalandurologynews.com)
  • In a 10-year follow up of survival in CASS (Coronary Artery Surgery Study), admittedly in an era when advances in medical therapeutics were only in their infancy, the presence of LV dysfunction represented an important discriminant for benefit from bypass graft surgery (1) . (onlinejacc.org)
  • Patterns of left ventricular dysfunction often do not follow coronary artery distributions, and may correlate with myocardial sympathetic innervation. (semanticscholar.org)