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Ventricular Dysfunction, LeftVentricular DysfunctionVentricular Dysfunction, RightStroke VolumeEchocardiographyHeart FailureVentricular Function, LeftNatriuretic Peptide, BrainCardiomyopathiesRadionuclide VentriculographyHemodynamicsMyocardial InfarctionMyocardial ContractionElectrocardiographyMyocardiumVentricular RemodelingErectile DysfunctionMyocardial StunningCardiomyopathy, DilatedHeartSystoleHeart VentriclesDobutamineMyocardial IschemiaEchocardiography, DopplerCardiotonic AgentsDiastoleTreatment OutcomeTakotsubo CardiomyopathyFollow-Up StudiesMitral Valve InsufficiencyAngiotensin-Converting Enzyme InhibitorsTime FactorsPrognosisEnalaprilPredictive Value of TestsProspective StudiesThallium RadioisotopesBiological MarkersVentricular Function, RightPulmonary EmbolismCoronary Artery BypassCoronary DiseaseExercise TestCardiac Output, LowTomography, Emission-Computed, Single-PhotonTransposition of Great VesselsDisease Models, AnimalSeverity of Illness IndexHeart DiseasesCoronary CirculationChronic DiseaseVentricular PressureMyocardial RevascularizationTissue SurvivalRisk FactorsArrhythmias, CardiacDefibrillators, ImplantableAtrial Natriuretic FactorRetrospective StudiesBlood PressureHeart Function TestsHeart RateHypertrophy, Left VentricularCardiac Pacing, ArtificialCardiac CatheterizationAortic Valve StenosisDogsTachycardia, VentricularVasodilator AgentsPreexisting Condition CoveragePulmonary Wedge PressureAdrenergic beta-AntagonistsCardiac VolumeCardiomegalyAtrial PressureRisk AssessmentAortic ValveHypertension, PulmonaryDeath, Sudden, CardiacSensitivity and SpecificityMyocytes, CardiacFibrosisTroponin ICoronary AngiographyEndocardial FibroelastosisAutonomic Nervous System DiseasesCardiac OutputAnti-Arrhythmia AgentsIntra-Aortic Balloon PumpingSurvival RateCoronary Artery DiseaseSexual Dysfunction, PhysiologicalMitral ValveAcute DiseaseEchocardiography, StressSurvival AnalysisCardiopulmonary BypassGated Blood-Pool ImagingHeart AtriaMyocarditisTechnetium Tc 99m SestamibiMilrinoneCase-Control StudiesPostoperative ComplicationsExercise ToleranceDouble-Blind MethodAnalysis of VarianceROC CurveMultivariate AnalysisSexual Dysfunctions, PsychologicalOxidative StressDiabetic CardiomyopathiesChagas CardiomyopathyAortic Valve InsufficiencyCardiac Surgical ProceduresHeart Valve ProsthesisEndomyocardial FibrosisTachycardia3-IodobenzylguanidineProportional Hazards ModelsRadionuclide AngiographyPostoperative PeriodChi-Square DistributionTechnetium Tc 99m PyrophosphateCoronary VesselsHeart Valve Prosthesis ImplantationEndothelium, VascularAtrioventricular BlockEchocardiography, Doppler, ColorDisease ProgressionPulmonary ArteryPeptide FragmentsRadiopharmaceuticalsAtrial FibrillationArterial PressureVentricular FunctionTomography, Emission-ComputedRecovery of FunctionHeart-Assist DevicesElectrocardiography, AmbulatoryCardiac Resynchronization TherapyCaptoprilIodobenzenesMice, Inbred C57BLReproducibility of ResultsPropanolaminesHeart TransplantationKaplan-Meier EstimateMagnetic Resonance ImagingDeathCardiovascular AgentsCentral Venous PressureAmiodaroneCohort StudiesObserver VariationAsymptomatic DiseasesHypertensionRats, WistarEchocardiography, Doppler, PulsedRats, Sprague-DawleyOxygen ConsumptionTroponin TDiureticsElectric CountershockEnoximoneXamoterolTricuspid Valve InsufficiencyLinear ModelsTetralogy of FallotMyocardial ReperfusionPuerperal DisordersMineralocorticoid Receptor AntagonistsPostoperative CareSpironolactoneComorbidityVascular ResistanceDipyridamoleSulfonesDilatation, PathologicHospitalizationHeart Failure, SystolicNatriuretic PeptidesMice, TransgenicStatistics, NonparametricAnaerobic ThresholdNitroprussideParasympatholyticsEndothelin-1Myocardial Reperfusion InjuryBlood Flow VelocityMice, KnockoutShock, CardiogenicNitric OxideHeart BlockNorepinephrinePrevalenceDose-Response Relationship, DrugAge FactorsHeart Valve DiseasesRegression Analysis
Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.Ventricular Dysfunction: A condition in which HEART VENTRICLES exhibit impaired function.Ventricular Dysfunction, Right: A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.Stroke Volume: The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Ventricular Function, Left: The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.Natriuretic Peptide, Brain: A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Radionuclide Ventriculography: Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Myocardial Contraction: Contractile activity of the MYOCARDIUM.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Ventricular Remodeling: The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.Erectile Dysfunction: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.Myocardial Stunning: Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.Heart: The hollow, muscular organ that maintains the circulation of the blood.Systole: Period of contraction of the HEART, especially of the HEART VENTRICLES.Heart Ventricles: The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.Dobutamine: A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Echocardiography, Doppler: Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.Cardiotonic Agents: Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).Diastole: Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Takotsubo Cardiomyopathy: A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This abnormality is associated with high levels of CATECHOLAMINES, either administered or endogenously secreted from a tumor or during extreme stress.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Mitral Valve Insufficiency: Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.Angiotensin-Converting Enzyme Inhibitors: A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Enalapril: An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Thallium Radioisotopes: Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Ventricular Function, Right: The hemodynamic and electrophysiological action of the right HEART VENTRICLE.Pulmonary Embolism: Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.Coronary Artery Bypass: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.Tomography, Emission-Computed, Single-Photon: A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.Transposition of Great Vessels: A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Ventricular Pressure: The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.Myocardial Revascularization: The restoration of blood supply to the myocardium. (From Dorland, 28th ed)Tissue Survival: The span of viability of a tissue or an organ.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Defibrillators, Implantable: Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.Atrial Natriuretic Factor: A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Heart Function Tests: Examinations used to diagnose and treat heart conditions.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Hypertrophy, Left Ventricular: Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.Cardiac Pacing, Artificial: Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.Aortic Valve Stenosis: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).Vasodilator Agents: Drugs used to cause dilation of the blood vessels.Preexisting Condition Coverage: Insurance coverage of a physical or mental health condition, disability, or illness existing before health insurance is applied for or enrolled in.Pulmonary Wedge Pressure: The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.Adrenergic beta-Antagonists: Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.Cardiac Volume: The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.Atrial Pressure: The pressure within the CARDIAC ATRIUM. It can be measured directly by using a pressure catheter (see HEART CATHETERIZATION). It can be also estimated using various imaging techniques or other pressure readings such as PULMONARY CAPILLARY WEDGE PRESSURE (an estimate of left atrial pressure) and CENTRAL VENOUS PRESSURE (an estimate of right atrial pressure).Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Aortic Valve: The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Myocytes, Cardiac: Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Troponin I: One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Endocardial Fibroelastosis: A condition characterized by the thickening of ENDOCARDIUM due to proliferation of fibrous and elastic tissue, usually in the left ventricle leading to impaired cardiac function (CARDIOMYOPATHY, RESTRICTIVE). It is most commonly seen in young children and rarely in adults. It is often associated with congenital heart anomalies (HEART DEFECTS CONGENITAL;) INFECTION; or gene mutation. Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis.Autonomic Nervous System Diseases: Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.Cardiac Output: The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Intra-Aortic Balloon Pumping: Counterpulsation in which a pumping unit synchronized with the patient's electrocardiogram rapidly fills a balloon in the aorta with helium or carbon dioxide in early diastole and evacuates the balloon at the onset of systole. As the balloon inflates, it raises aortic diastolic pressure, and as it deflates, it lowers aortic systolic pressure. The result is a decrease in left ventricular work and increased myocardial and peripheral perfusion.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.Sexual Dysfunction, Physiological: Physiological disturbances in normal sexual performance in either the male or the female.Mitral Valve: The valve between the left atrium and left ventricle of the heart.Acute Disease: Disease having a short and relatively severe course.Echocardiography, Stress: A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Cardiopulmonary Bypass: Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.Gated Blood-Pool Imaging: Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).Heart Atria: The chambers of the heart, to which the BLOOD returns from the circulation.Myocarditis: Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.Technetium Tc 99m Sestamibi: A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.Milrinone: A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Exercise Tolerance: The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.ROC Curve: A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Sexual Dysfunctions, Psychological: Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Diabetic Cardiomyopathies: Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.Chagas Cardiomyopathy: A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.Aortic Valve Insufficiency: Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).Cardiac Surgical Procedures: Surgery performed on the heart.Heart Valve Prosthesis: A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.Endomyocardial Fibrosis: A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.3-Iodobenzylguanidine: A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Radionuclide Angiography: The measurement of visualization by radiation of any organ after a radionuclide has been injected into its blood supply. It is used to diagnose heart, liver, lung, and other diseases and to measure the function of those organs, except renography, for which RADIOISOTOPE RENOGRAPHY is available.Postoperative Period: The period following a surgical operation.Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Technetium Tc 99m Pyrophosphate: A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.Coronary Vessels: The veins and arteries of the HEART.Heart Valve Prosthesis Implantation: Surgical insertion of synthetic material to repair injured or diseased heart valves.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Atrioventricular Block: Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.Echocardiography, Doppler, Color: Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Pulmonary Artery: The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Radiopharmaceuticals: Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.Arterial Pressure: The blood pressure in the ARTERIES. It is commonly measured with a SPHYGMOMANOMETER on the upper arm which represents the arterial pressure in the BRACHIAL ARTERY.Ventricular Function: The hemodynamic and electrophysiological action of the HEART VENTRICLES.Tomography, Emission-Computed: Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.Recovery of Function: A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.Heart-Assist Devices: Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.Electrocardiography, Ambulatory: Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.Cardiac Resynchronization Therapy: The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.IodobenzenesMice, Inbred C57BLReproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Propanolamines: AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.Heart Transplantation: The transference of a heart from one human or animal to another.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Death: Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Central Venous Pressure: The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Observer Variation: The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).Asymptomatic Diseases: Diseases that do not exhibit symptoms.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Echocardiography, Doppler, Pulsed: Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Oxygen Consumption: The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)Troponin T: One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.Diuretics: Agents that promote the excretion of urine through their effects on kidney function.Electric Countershock: An electrical current applied to the HEART to terminate a disturbance of its rhythm, ARRHYTHMIAS, CARDIAC. (Stedman, 25th ed)Enoximone: A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE.Xamoterol: A phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist.Tricuspid Valve Insufficiency: Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.Linear Models: Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.Tetralogy of Fallot: A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.Myocardial Reperfusion: Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.Puerperal Disorders: Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.Mineralocorticoid Receptor Antagonists: Drugs that bind to and block the activation of MINERALOCORTICOID RECEPTORS by MINERALOCORTICOIDS such as ALDOSTERONE.Postoperative Care: The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)Comorbidity: The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.Vascular Resistance: The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)SulfonesDilatation, Pathologic: The condition of an anatomical structure's being dilated beyond normal dimensions.Hospitalization: The confinement of a patient in a hospital.Heart Failure, Systolic: Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.Natriuretic Peptides: Peptides that regulate the WATER-ELECTROLYTE BALANCE in the body, also known as natriuretic peptide hormones. Several have been sequenced (ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; C-TYPE NATRIURETIC PEPTIDE).Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Statistics, Nonparametric: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)Anaerobic Threshold: The oxygen consumption level above which aerobic energy production is supplemented by anaerobic mechanisms during exercise, resulting in a sustained increase in lactate concentration and metabolic acidosis. The anaerobic threshold is affected by factors that modify oxygen delivery to the tissues; it is low in patients with heart disease. Methods of measurement include direct measure of lactate concentration, direct measurement of bicarbonate concentration, and gas exchange measurements.Nitroprusside: A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.Parasympatholytics: Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.Endothelin-1: A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)Myocardial Reperfusion Injury: Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Shock, Cardiogenic: Shock resulting from diminution of cardiac output in heart disease.Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Heart Block: Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.

Global biventricular dysfunction in patients with asymptomatic coronary artery disease may be caused by myocarditis. (1/312)

BACKGROUND: The causal role of asymptomatic critical coronary artery obstruction in patients presenting with severe global biventricular dysfunction but no evidence of myocardial infarction is uncertain. METHODS AND RESULTS: Among 291 patients aged >40 years undergoing a noninvasive (2-dimensional echocardiography) and invasive (catheterization, coronary angiography, and biventricular endomyocardial biopsy, 6 to 8 samples/patient) cardiac study because of progressive heart failure (New York Heart Association functional class III or IV) with global biventricular dysfunction and no history of myocardial ischemic events, 7 patients (2.4%; 7 men; mean age, 49+/-6.9 years) had severe coronary artery disease (3 vessels in 4 patients; 2 vessels in 1 patient, proximal occlusion of left anterior descending coronary artery in 2 patients). Left ventricular end-diastolic diameter and ejection fraction by 2-dimensional echocardiography were 73+/-10.5 mm and 23+/-6.5%, respectively, and right ventricular end-diastolic diameter and ejection fraction were 39+/-7 mm and 29+/-7.2%, respectively. Biopsy specimens showed extensive lymphocytic infiltrates with focal myocytolysis meeting the Dallas criteria for myocarditis in all patients (in 5 patients with and 2 patients without fibrosis). Cardiac autoantibodies were detected with indirect immunofluorescence in the serum of 2 patients with active myocarditis. The 2 patients with active inflammation received prednisone (1 mg. kg-1. d-1 for 4 weeks followed by 0.33 mg. kg-1. d-1 for 5 months) and azathioprine (2 mg. kg-1. d-1 for 5 months) in addition to conventional drug therapy for heart failure. At 8-month overall follow-up, cardiac volume and function improved considerably in immunosuppressed patients but remained unchanged in conventionally treated patients, of whom 1 died. CONCLUSIONS: Global biventricular dysfunction in patients with severe asymptomatic coronary artery disease and no evidence of previous myocardial infarction may be caused by myocarditis. Histologic findings may influence the treatment.  (+info)

Prognostic value of dobutamine stress echocardiography in predicting cardiac events in patients with known or suspected coronary artery disease. (2/312)

OBJECTIVES: The study sought to determine the utility of dobutamine stress echocardiography (DSE) in predicting cardiac events in the year after testing. BACKGROUND: Increasingly, DSE has been applied to risk stratification of patients. METHODS: Medical records of 1,183 consecutive patients who underwent DSE were reviewed. The cardiac events that occurred during the 12 months after DSE were tabulated: myocardial infarction (MI), cardiac death, percutaneous transluminal coronary angioplasty (PTCA), and coronary artery bypass surgery (CABG). Patient exclusions included organ transplant receipt or evaluation, recent PTCA, noncardiac death, and lack of follow-up. A positive stress echocardiogram (SE) was defined as new or worsened wall-motion abnormalities (WMAs) consistent with ischemia during DSE. Classification and regression tree (CART) analysis identified variables that best predicted future cardiac events. RESULTS: The average age was 68+/-12 years, with 338 women and 220 men. The overall cardiac event rate was 34% if SE was positive, and 10% if it was negative. The event rates for MI and death were 10% and 8%, respectively, if SE was positive, and 3% and 3%, respectively, if SE was negative. If an ischemic electrocardiogram (ECG) and a positive SE were present, the overall event rate was 42%, versus a 7% rate when ECG and SE were negative for ischemia. Rest WMA was the most useful variable in predicting future cardiac events using CART: 25% of patients with and 6% without a rest WMA had an event. Other important variables were a dobutamine EF <52.5%, a positive SE, an ischemic ECG response, history of hypertension and age. CONCLUSIONS: A positive SE provides useful prognostic information that is enhanced by also considering rest-wall motion, stress ECG response, and dobutamine EF.  (+info)

Design and results of the antiarrhythmics vs implantable defibrillators (AVID) registry. The AVID Investigators. (3/312)

BACKGROUND: The Antiarrhythmics Versus Implantable Defibrillators (AVID) Study compared treatment with implantable cardioverter-defibrillators versus antiarrhythmic drugs in patients with life-threatening ventricular arrhythmias (VAs). AVID maintained a Registry on all patients, randomized or not, with any VA or unexplained syncope who could be considered for either of the treatment strategies. Trial-eligible arrhythmias were the categories of VF cardiac arrest, Syncopal VT, and Symptomatic VT, below. METHODS AND RESULTS: Of 5989 patients screened, 4595 were registered and 1016 were randomized. Mortality follow-up through 1996 was obtained on the 4219 Registry patients enrolled before 1997 through the National Death Index. Crude mortality rates (mean+/-SD, follow-up, 16.9+/-11.5 months) were: VF cardiac arrest, 17.0% (n=1399, 238 deaths); Syncopal VT, 21.2% (n=598, 127 deaths); Symptomatic VT, 15.8% (n=1065, 168 deaths); Stable (asymptomatic) VT, 19.7% (n=497, 98 deaths); VT/VF with transient/correctable cause, 17.8% (n=270, 48 deaths); and Unexplained syncope, 12.3% (n=390, 48 deaths). CONCLUSIONS: Patients with seemingly lower-risk or unknown-risk VAs (asymptomatic VT, and VT/VF associated with a transient factor) have a (high) mortality similar to that of higher-risk, AVID-eligible VAs. The similar (and poor) prognosis of most patients with VT/VF suggests the need for reevaluation of a priori risk grouping and raises the question of the appropriate arrhythmia therapy for a broad range of patients.  (+info)

Myocardial ischaemia in children with isolated ventricular non-compaction. (4/312)

AIMS: Isolated ventricular non-compaction is a rare congenital cardiomyopathy with a high morbidity and mortality due to malignant arrhythmias and pump failure. Areas affected by non-compaction are characterized by increased trabecularization and deep inter-trabecular spaces. We hypothesized perfusion defects in these areas and performed positron emission tomography to evaluate the myocardial perfusion in non-compacted areas. METHODS AND RESULTS: Five children (age 10-14 years) with isolated ventricular non-compaction underwent positron emission tomography using N-13-ammonia as flow marker and intravenous dipyridamole for stress testing. Myocardial blood flow was quantified using the positron emission tomography time-activity curves in non-compacted areas and normal myocardium, which were diagnosed by echocardiography, magnetic resonance imaging, and angiography. Coronary angiography, performed in two children with extensive forms of left ventricular non-compaction, demonstrated normal coronary arteries. Myocardial blood flow measurements at rest and after dipyridamole application demonstrated 16-33% and 32-57% perfusion impairment, respectively, in non-compacted areas compared to normal myocardium. Areas of restricted myocardial perfusion corresponded well to the non-compacted areas, defined echographically and by magnetic resonance imaging. CONCLUSION: Positron emission tomography demonstrates restricted myocardial perfusion and decreased flow reserve in areas of ventricular non-compaction in children. The myocardial perfusion defects in non-compacted areas may be the cause of myocardial damage and possibly form the basis of arrhythmias and pump failure.  (+info)

Abnormal cardiac repolarization and impulse initiation in German shepherd dogs with inherited ventricular arrhythmias and sudden death. (5/312)

OBJECTIVE: We tested the hypothesis that delayed afterdepolarization (DAD)-associated rhythms in German shepherd dogs with reduced anteroseptal left ventricular (LV) sympathetic innervation derive from abnormal beta-adrenergic receptor effector coupling. METHODS AND RESULTS: In anteroseptal LV midmyocardium of afflicted dogs, beta-receptor density was greater than that in normal dogs (P < .05), with affinity being equal in both groups. Basal and maximum isoproterenol (ISO) stimulated adenylyl cyclase activity of anteroseptal LV of afflicted dogs was greater than that in normal dogs (P < .05). Isolated anteroseptal M cell preparations of afflicted dogs studied with microelectrodes showed abnormal lengthening, rather than shortening of action potential duration in response to ISO, as well as a 61% incidence of 10(-7) mol/l ISO-induced triggered activity as compared to 12% in normals (P < .05). In contrast, there was no difference between afflicted and control dogs in triggered activity, beta-receptors or adenylyl cyclase activity in a normally innervated region of the ventricles. CONCLUSION: In this model there is an increase in beta-receptor density and beta-adrenergic stimulation of adenylyl cyclase and of triggered activity in anteroseptal myocardium but not in a normally innervated region of the heart. Hence, abnormal beta-adrenergic signal transduction appears associated with the neural abnormality identified in dogs with inherited VT.  (+info)

Losartan improves diastolic ventricular filling of hypertensive patients with diastolic dysfunction. (6/312)

To evaluate the role of losartan on left ventricular (LV) function of hypertensive patients. Hypertensive patients (n = 19) underwent evaluation of systolic and diastolic LV function, using radionuclide ventriculography (RVG), before and at 3 mo into the treatment with the angiotensin II antagonist losartan. All patients underwent a baseline 12 lead ECG and an echocardiogram (ECHO), which was also repeated at 3 mo into treatment. Results are expressed as mean +/- SEM and statistics were performed using paired t-test. A p value < or = 0.05 was considered significant. Treatment with losartan for 3 mo had no effect on LV mass measured by echo (141+/-5 vs. 139+/-6 g/m2). The LV ejection fraction, measured by RVG, was unchanged by treatment when compared to the baseline study (58+/-2% vs. 57+/-2%, respectivelly, p = 0.49). Considering all patients involved in the study (n = 19), the LV "Peak Filling Rate" (PFR), a parameter of diastolic function measured by RVG, was also unchanged by treatment when compared to baseline (2.5+/-0.2 EDV/s vs. 2.5+/-0.3 EDV/s, respectively, p = 0.9). However the analysis of those patients with evidence of diastolic dysfunction (n = 12) on the baseline RVG (PFR < 2.5 EVD/s), demonstrated significant improvement of LV filling after therapy with losartan (PFR = 1.8+/-0.1 EDV/s vs. 2.3 +/-0.2 EDV/s, respectively, p = 0.05). This change was associated with improvement of symptoms. Our results demonstrated that hypertensive patients with diastolic dysfunction on radionuclide ventriculography have significant improvement of ventricular filling at 3 mo into treatment with losartan.  (+info)

Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia. (7/312)

BACKGROUND: To date, the lack of potent and selective inhibitors has hampered the physiological assessment of modulation of the cardiac slowly activating delayed rectifier current, I(Ks). The present study, using the I(Ks) blocker L-768,673, represents the first in vivo assessment of the cardiac electrophysiological and antiarrhythmic effects of selective I(Ks) blockade. METHODS AND RESULTS: In an anesthetized canine model of recent (8.5+/-0.4 days) anterior myocardial infarction, 0.003 to 0.03 mg/kg L-768,673 IV significantly suppressed electrically induced ventricular tachyarrhythmias and reduced the incidence of lethal arrhythmias precipitated by acute, thrombotically induced posterolateral myocardial ischemia. Antiarrhythmic protection afforded by L-768,673 was accompanied by modest 7% to 10% increases in noninfarct zone ventricular effective refractory period, 3% to 5% increases in infarct zone ventricular effective refractory period, and 4% to 6% increases in QTc interval. In a conscious canine model of healed (3 to 4 weeks) anterior myocardial infarction, ventricular fibrillation was provoked by transient occlusion of the left circumflex coronary artery during submaximal exercise. Pretreatment with 0.03 mg/kg L-768,673 IV elicited a modest 7% increase in QTc, prevented ventricular fibrillation in 5 of 6 animals, and suppressed arrhythmias in 2 additional animals. CONCLUSIONS: The present findings suggest that selective blockade of I(Ks) may be a potentially useful intervention for the prevention of malignant ischemic ventricular arrhythmias.  (+info)

Baroreflex sensitivity predicts the induction of ventricular arrhythmias by cesium chloride in rabbits. (8/312)

Previous studies have shown that the autonomic nervous system plays an important role in the genesis of ventricular tachycardia (VT) in patients with long QT syndrome, and in cesium chloride (Cs)-induced VT in animals. The present study investigated whether baroreflex sensitivity predicts the induction of VT by Cs in the rabbit in vivo. Monophasic action potentials (MAPs) of the left ventricular endocardium were recorded simultaneously with the surface ECG in 27 rabbits. Rabbits were divided into 4 groups based on the Cs-induced ventricular arrhythmias: (1) no ventricular premature contractions (No-VPC group), (2) single or paired VPC (VPC group), (3) monomorphic VT (MVT group), and (4) polymorphic VT (PVT group). Baroreflex sensitivity was significantly lower in the MVT and PVT groups than in the No-VPC and VPC groups. The plasma norepinephrine concentration before Cs injection was significantly higher in the MVT group than in the other 3 groups, and the norepinephrine concentration after Cs injection was significantly higher in the MVT and PVT groups than in the No-VPC and VPC groups. Baroreflex sensitivity was negatively correlated with the norepinephrine concentration before Cs injection. These results suggest that autonomic nervous system dysfunction, as defined by reduced baroreflex sensitivity, and elevated plasma norepinephrine concentrations predict increased susceptibility to Cs-induced VT.  (+info)

Effect of Shock Wave-Facilitated Intracoronary Cell Therapy on LVEF in Patients With Chronic Heart Failure: The CELLWAVE...Effect of Shock Wave-Facilitated Intracoronary Cell Therapy on LVEF in Patients With Chronic Heart Failure: The CELLWAVE...
The CELLWAVE double-blind, randomized, placebo-controlled trial was conducted among patients with CHF treated at Goethe University Frankfurt, Germany, between 2006 and 2011. This was a single-blind study of low-dose (n = 42), high-dose (n = 40), or placebo (n = 21) shock wave pretreatment targeted to the LV anterior wall. Twenty-four hours later, patients receiving shock wave pretreatment were randomized to receive double-blind intracoronary infusion of BMCs or placebo, and patients receiving placebo shock wave received intracoronary infusion of BMCs. The primary endpoint was change in LVEF from baseline to 4 months in the pooled groups shock wave + placebo infusion versus shock wave + BMCs; secondary endpoints included regional LV function assessed by magnetic resonance imaging and clinical events.. ...
Cordarone X Intravenous, 150mg/3ml, Concentrate for solution for infusion or slow injection | Medicines.ieCordarone X Intravenous, 150mg/3ml, Concentrate for solution for infusion or slow injection | Medicines.ie
PGD is a life-threatening complication of heart transplantation that presents as left, right or biventricular dysfunction occurring within the first 24 hours of transplant surgery for which there is no identifiable secondary cause (see Section 4.8). Severe PGD may be irreversible.. For patients who are on the heart transplant waiting list, consideration should be given to use an alternative antiarrhythmic drug as early as possible before transplant.. Section 4.8. Musculoskeletal and Connective Tissue Disorders:. ...
Angiography and the aetiology of heart failure. | Postgraduate Medical JournalAngiography and the aetiology of heart failure. | Postgraduate Medical Journal
The diagnosis of idiopathic dilated cardiomyopathy should not be made without first performing a coronary angiogram. If the cause of heart failure is unknown this should be stated rather than attributing the cause to dilated cardiomyopathy. Severe ventricular dysfunction may improve dramatically after revascularisation in some cases of coronary disease. Preservation of R waves on the surface electrocardiogram suggests the presence of hibernating myocardium but thallium scintigraphy or positron emission tomography scanning should be employed to investigate this further.. ...
Transesophageal Echocardiography (TEE) Workshops now offered - MTSATransesophageal Echocardiography (TEE) Workshops now offered - MTSA
April 18, 2021. The daylong workshops incorporate the HeartWorks TEE Simulator, a solution for developing cognitive and psychomotor skills for TEE. Users see real-time, seamless ultrasound imaging in synchronization with their movement of the TEE probe, providing a realistic and accurate training experience in preparation for real patient examinations.. Shields said 20 pathologies, including aortic stenosis, mitral regurgitation, biventricular dysfunction and cardiac tamponade, are featured in the training, along with interventional use for transcatheter procedures.. "Ultrasound allows us to see the structures of the heart, the size, whether the heart valve is working efficiently, among other assessments," Shields said. "We can look at different pathologies of the heart, such as the direction of blood flow, or whether theres a septal defect. Its used mainly for cardiopulmonary instability, blood pressure problems, and trouble with oxygenation and saturation.". Shields points to the fact that ...
NFE2L2NFE2L2
Cardiac resynchronization therapy (CRT) improves functional classification among patients with left ventricle malfunction and ventricular electric conduction disorders. and a HF group of 42 subjects (53.12 15.05 years, LVEF < 35%) were studied. The proposed classifiers had hit rates of 90%, 50%, and 80% to distinguish between absent, mild, and moderate-severe interventricular dyssynchrony, respectively. For […] ...
Browse In Portugal | EDM Case ReportsBrowse In Portugal | EDM Case Reports
Pheochromocytoma/paraganglioma (PPGL) are neuroendocrine tumors that can secrete catecholamines. The authors describe a challenging case who presented as stress cardiomyopathy and myocardial infarction (MI). A 76-year-old man, with a medical history of Parkinsons disease, type 2 diabetes mellitus, hypertension, dyslipidaemia and a previous inferior MI in 2001, presented to the emergency department due to chest pain, headaches and vomiting. He also reported worsening blood glucose levels and increasing constipation over the preceding weeks. BP was 185/89 mmHg (no other relevant findings). EKG had ST segment depression in leads V2-V6, T troponin was 600 ng/L (,14) and the echocardiogram showed left ventricular hypokinesia with mildly compromised systolic function. Nevertheless, he rapidly progressed to severe biventricular dysfunction. Coronary angiogram showed a 90% anterior descendent coronary artery occlusion (already present in 2001), which was treated with angioplasty/stenting. In the ...
GEORGE QUINTERO , DDS | Dentist in 42701GEORGE QUINTERO , DDS | Dentist in 42701
DentalPlans detailed profile of GEORGE QUINTERO , DDS - Dentist in 42701. View plans, sample savings & pricing, patient reviews & practice information.
Lotensin User Reviews for Left Ventricular Dysfunction at Drugs.comLotensin User Reviews for Left Ventricular Dysfunction at Drugs.com
Reviews and ratings for lotensin when used in the treatment of left ventricular dysfunction. Share your experience with this medication by writing a review.
The Treatment of Ventricular Dyssynchrony | Health And WellnessThe Treatment of Ventricular Dyssynchrony | Health And Wellness
This is a widget area - If you go to "Appearance" in your WP-Admin you can change the content of this box in "Widgets", or you can remove this box completely under "Theme Options" ...
Cell-Wave Study: Combined Extracorporal Shock Wave Therapy and Intracoronary Cell Therapy in Chronic Ischemic Myocardium - Full...Cell-Wave Study: Combined Extracorporal Shock Wave Therapy and Intracoronary Cell Therapy in Chronic Ischemic Myocardium - Full...
Extracorporal shock wave therapy is performed prior to cell therapy for induction of therapeutic neovascularization and improvement of homing of bone marrow progenitor cells in patients with chronic ischemic heart disease following anterior myocardial infarction.. Shock waves can induce growth factor expression in the ischemic myocardium and might augment homing of autologous bone marrow mononuclear cells which are injected intracoronary 24 h following shock wave therapy ...
Right Ventricular Function, Peripheral Edema, and Acute Kidney Injury in Critical IllnessRight Ventricular Function, Peripheral Edema, and Acute Kidney Injury in Critical Illness
The cardiorenal syndrome generally focuses on left ventricular function, and the importance of the right ventricle as a determinant of renal function is described less frequently. In a cohort of critically ill patients with echocardiographic measurements obtained within 24 hours of admission to the intensive care unit, we examined the association of right ventricular function with acute kidney injury (AKI) and AKI-associated mortality. We also examined whether clinical measurement of volume overload modified the association between ventricular function and AKI in a subpopulation with documented admission physical examinations. Among 1879 critically ill patients with echocardiographic ventricular measurements, 43% (n = 807) had ventricular dysfunction-21% (n = 388), 9% (n = 167), and 13% (n = 252) with isolated left ventricular dysfunction, isolated right ventricular dysfunction, and biventricular dysfunction, respectively. Overall, ventricular dysfunction was associated with a 43% higher ...
Torsades de Pointes During Methadone Treatment | Revista Española de Cardiología (English Edition)Torsades de Pointes During Methadone Treatment | Revista Española de Cardiología (English Edition)
Figure. QTc interval prolongation and an episode of polymorphic ventricular tachycardia are observed.. The biochemical parameters showed low serum potassium concentrations in 2 cases, whereas calcium and magnesium levels were normal in all patients. In addition, various toxic substances were detected in urine.. The echocardiogram showed severe biventricular dysfunction in 1 of the patients; ventricular function was normal in all others. After methadone was discontinued and magnesium sulfate, isoproterenol perfusion, and potassium supplements were started, polymorphic ventricular tachycardia disappeared within 7 hours of admission. After 2-3 days, methadone treatment was resumed at the usual doses, with the QTc interval progressively returning to normal in 3 cases; the fourth patient requested voluntary withdrawal before the study was completed.. DISCUSSION. Methadone has been widely used for the treatment of heroine addiction and chronic pain for more than 3 decades. It is generally ...
Evaluation of cardiac dyssynchrony with longitudinal strain analysisin 4-chamber cine MR imaging<...Evaluation of cardiac dyssynchrony with longitudinal strain analysisin 4-chamber cine MR imaging<...
TY - JOUR. T1 - Evaluation of cardiac dyssynchrony with longitudinal strain analysisin 4-chamber cine MR imaging. AU - Kawakubo, Masateru. AU - Nagao, Michinobu. AU - Kumazawa, Seiji. AU - Chishaki, Akiko S.. AU - Mukai, Yasushi. AU - Nakamura, Yasuhiko. AU - Honda, Hiroshi. AU - Morishita, Junji. PY - 2013/12. Y1 - 2013/12. N2 - Purpose: We investigated the clinical performance of evaluation of cardiac mechanical dyssynchrony withlongitudinal strain analysis using four-chamber (4CH) cine magnetic resonance imaging (MRI).Materials and methods: We retrospectively enrolled 73 chronic heart failure patients (41 men, 32 women;mean age, 57 years, NYHA 2, 3, and 4) who underwent a cardiac MRI in the present study. The left ventricu-lar dyssynchrony (LVD) and interventricular dyssynchrony (IVD) indices were calculated by longitudinalstrain analysis using 4CH cine MRI. The LVD and IVD indices were compared by the Wilcoxon rank-sumtest between the patients with indication for cardiac resynchronization ...
Abstract 14633: Cardiopulmonary Exercise Testing as a Predictor of Liver Disease in Fontan Patients: Two Tertiary Center...Abstract 14633: Cardiopulmonary Exercise Testing as a Predictor of Liver Disease in Fontan Patients: Two Tertiary Center...
Introduction: Liver disease (LD) is a known long-term complication in single ventricle patients who undergo Fontan procedures. Cardiopulmonary exercise test (CPET) variables are known to be associated with increased risk of hospitalization in Fontan patients but their association with liver disease is unknown.. Methods/Results: We retrospectively reviewed medical records from 2 tertiary academic institutions (Central Manchester University Hospitals, UK and University of California San Francisco, USA) and identified 114 adult Fontan patients (,18 years). LD was defined as grade IV fibrosis or cirrhosis on either ultrasound or computed tomographic imaging. Mean age was 30.9 ± 7.4 years, age at Fontan 7.9 ± 7.9 years, 56% were females, 63% underwent total cavopulmonary connection, 66% had New York Heart Association (NYHA) I, 42% had arrhythmias, 22% had systemic right ventricle and 35% had ventricular dysfunction. Of 81 patients with liver imaging data, 33 (41%) had LD. There were no differences ...
Heart transplantation in Fontan patients across Australia and New Zealand | HeartHeart transplantation in Fontan patients across Australia and New Zealand | Heart
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Voiding Dysfunction | NemoursVoiding Dysfunction | Nemours
Our pediatric urologists have the experience and sensitivity to care for children with voiding dysfunction in a way that helps them feel comfortable.
Promise of Blood- and Bone Marrow-Derived Stem Cell Transplantation for Functional Cardiac Repair | JACC: Journal of the...Promise of Blood- and Bone Marrow-Derived Stem Cell Transplantation for Functional Cardiac Repair | JACC: Journal of the...
A meta-analysis by Lipinski et al. (5) included 10 of these trials (7 randomized, 3 cohort studies) on intracoronary cell injection (within the first 14 days after infarction), yielding 698 patients, of which 659 were available at follow-up (median follow-up of 6 months). In 2 trials (n = 126), peripheral blood cells were used for intracoronary infusion and in 8 investigations bone marrow-derived cells were used. For the pooled population, Lipinski et al. (5) found a significantly superior improvement in LVEF of 3.0% (95% confidence interval: 1.9% to 4.1%, p , 0.00001) for subjects receiving bone marrow transplantation in comparison with control subjects. Similarly, LV end-systolic volumes were reduced in patients receiving cell therapy by -7.4 ml (95% confidence interval: -12.2 to -2.7 ml, p , 0.002) compared with control subjects. Changes in end-diastolic volumes were not significantly different between groups in this meta-analysis.. Clinical end points, such as death, target vessel ...
Fontan Patients: Comprehensive Evaluation of Pulmonary Circulation and Ventricular Function - Full Text View - ClinicalTrials...Fontan Patients: Comprehensive Evaluation of Pulmonary Circulation and Ventricular Function - Full Text View - ClinicalTrials...
In patients with one anatomical or functional ventricular chamber, which encompasses a spectrum of rare and complex congenital cardiac malformations, a staged surgical approach in view of an ultimate Fontan operation has become the procedure of choice. Especially in the earlier era, perioperative mortality was the leading cause of death. However, many patients have a long and high-quality life, continuously improved by a better understanding of Fontan hemodynamics and the refinement of the surgical procedures. Nevertheless, the prospect of eventual failure of the Fontan circulation remains a major concern. More specifically, evaluation of the pulmonary circulation becomes particularly important as the failing Fontan circulation has become a common indication for cardiac transplantation. Although essential, especially in the preoperative setting, a comprehensive evaluation of the pulmonary circulation remains difficult in this patient population. Our global hypothesis is that the absence of ...
Quintero banged up, but not in serious danger | VeloNews.comQuintero banged up, but not in serious danger | VeloNews.com
SAN REMO, Italy (VN) - Colombian rider Carlos Quintero will spend the night in an Italian hospital after suffering a concussion, but he is not facing life-threatening injuries in the wake of a nasty fall in Milan-San Remo.. For a few moments Saturday afternoon it looked like cycling was facing another worst-case scenario when the Colombia-Coldeportes rider crashed heavily on the descent of Le Mànie. Television images of doctors hurriedly treating the Coldeportes rider brought back the horrible images of last years Giro dItalia, when Wouter Weylandt died during a similar high-speed fall.. There was no official word from the team, but race officials confirmed that Quintero suffered a concussion and momentarily lost consciousness in the wake of his crash.. He was later transported to a hospital where a CT scan ruled out any serious brain injury. X-rays revealed a fracture to his left cheekbone and shoulder blade and a contusion to his left lung. Doctors are keeping him in the hospital overnight ...
Abstract 14676: Evidence for Electromechanical Coupling in Patients With Cardiac Resynchronization Therapy From...Abstract 14676: Evidence for Electromechanical Coupling in Patients With Cardiac Resynchronization Therapy From...
Introduction: Experiments in dogs with left bundle branch block (LBBB) showed a strong relation between electrical (QRS-vector amplitude, QRSVampl) and mechanical interventricular dyssynchrony. We investigated this relation in patients with previously implanted devices for cardiac resynchronization therapy (CRT) using echocardiography and vectorcardiography.. Methods: To induce different degrees of left (LV) and right ventricular (RV) pre-excitation, single site LV pacing at many AV-delays was performed in 20 LBBB patients in sinus rhythm, and biventricular pacing at many VV-delays in 18 patients with complete AV-block. At all pacing settings 3D-vectorcardiograms and echocardiograms were recorded. QRSVampl was defined negative when the spatial vector direction differed ,90° from LBBB or RV-pacing. Interventricular mechanical dyssynchrony (IVMD) was determined from Doppler recordings and septal strain from speckle tracking. Septal systolic rebound stretch (SRS) and pre-stretch (SPS) were ...
A CMR study of the effects of tissue edema and necrosis on left ventricular dyssynchrony in acute myocardial infarction:...A CMR study of the effects of tissue edema and necrosis on left ventricular dyssynchrony in acute myocardial infarction:...
In acute myocardial infarction (AMI), both tissue necrosis and edema are present and both might be implicated in the development of intraventricular dyssynchrony. However, their relative contribution to transient dyssynchrony is not known. Cardiovascular magnetic resonance (CMR) can detect necrosis and edema with high spatial resolution and it can quantify dyssynchrony by tagging techniques. Patients with a first AMI underwent percutaneous coronary interventions (PCI) of the infarct-related artery within 24 h of onset of chest pain. Within 5-7 days after the event and at 4 months, CMR was performed. The CMR protocol included the evaluation of intraventricular dyssynchrony by applying a novel 3D-tagging sequence to the left ventricle (LV) yielding the CURE index (circumferential uniformity ratio estimate; 1 = complete synchrony). On T2-weighted images, edema was measured as high-signal (|2 SD above remote tissue) along the LV mid-myocardial circumference on 3 short-axis images (% of circumference
Urinary biopyrrins levels are elevated in relation to severity of heart failure | JACC: Journal of the American College of...Urinary biopyrrins levels are elevated in relation to severity of heart failure | JACC: Journal of the American College of...
To the best of our knowledge, this is the first clinical report to analyze the urinary levels of biopyrrins in patients with HF. The present study provides clinical evidence that the urinary levels of biopyrrins/creatinine are changed in association with both NYHA functional class and plasma levels of BNP.. Recently, increases in plasma biochemical markers of oxidative stress have been reported in patients with HF (17,18). There is a definitive correlation between oxidative stress and ventricular dysfunction (2,4). Furthermore, ventricular remodeling and progressive dilation leading to end-stage HF may be mediated by oxygen-derived free radicals (2,4). Therefore, it is likely that ROS are involved in not only the pathogenesis but also the active progression of HF (3-6). In an attempt to prevent the production of oxidants, as well as to ameliorate and repair oxidative tissue damage, detoxification systems are present in vivo and comprise both enzymatic and nonenzymatic antioxidant compounds. ...
16S rRNA Amplicon Sequencing of Seawater Microbiota from Quintero Bay, Chile, Affected by Oil Spills, Shows the Presence of an...16S rRNA Amplicon Sequencing of Seawater Microbiota from Quintero Bay, Chile, Affected by Oil Spills, Shows the Presence of an...
The Quintero Bay, located along the central Pacific coast of Chile, stands out due to its intense port and industrial activities, such as crude oil refining, thermoelectric generation, and mining. These activities occur close to urban areas and coexist with tourism, agriculture, aquaculture, and artisanal fishing. Since 2014, three major oil spills have occurred, generating a great social, ecological, and economic impact. This report describes the microbial community in seawater of two marine areas of the Quintero Bay through a 16S rRNA amplicon analysis.. Two seawater samples from the Quintero Bay were taken in autumn (23 May 2016) by a diver using sterile nuclease-free sampling bottles. Sample CGB1062-1 (10 m deep, 11°C) was taken near shipping docks (32°45′42″S, 71°29′44″W), while sample CGB1062-2 (10 m deep, 10°C) was sampled from the northwest area (32°44′05″S, 71°30′14″W). Samples were immediately preserved at 4°C for 1 h, and metagenomic DNA was extracted using a ...
Left Ventricular Dysfunction - Market Insights, Epidemiology and Market Forecast - 2025 - RnR Market ResearchLeft Ventricular Dysfunction - Market Insights, Epidemiology and Market Forecast - 2025 - RnR Market Research
Left Ventricular Dysfunction - Market Insights, Epidemiology and Market Forecast - 2025 is a market research report available at US $5750 for a Single User PDF License from RnR Market Research Reports Library.
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Methods and Results:. Pre-Fontan catheterisation data and Fontan pressure measured at the completion were retrospectively collected. Pre-Fontan data were used to calculate the predicted pressure in the Fontan system. The predicted values were compared to the Fontan pressure measured at the Fontan completion and with the needs for fenestration. One hundred twenty-four Fontan patients were retrospectively enrolled (At Fontan: median age 30.73 [24.70-37.20] months, median weight 12.00 [10.98-14.15] kg). Fontan conduit was fenestrated in 78 patients. A poor correlation (r2 = 0.05128) between the measured and predicted data for non-fenestrated patients was observed. In the case of Fontan-predicted pressure ,17.59 mmHg, the formula identified a good short-term clinical outcome with a sensitivity of 92%. ...
Julià Sapé, M. M.<...Julià Sapé, M. M.<...
Arus Caralto, C., Nebot Sánchez, J., Coronel Linárez, I. E., Portas Ferreira Simoes, R. V., Valverde Saubí, D., Aguilera Grijalvo, C., Acebes Martin, J. J., Aparicio Caballero, A., Cabañas Egaña, M., Castañer Llanes, S., Cos Domingo, M., Godino Maritínez, O., Julià Sapé, M. M., Majós Torró, C., Mercadal Díaz, G., Quintero Bernabeu, M. R. & Serrallonga Mercader, M.. Ministerio de Educación y Ciencia. 13/12/05 → 13/12/08. Project ...
Effects of glucose-insulin-potassium infusion on chronic ischaemic left ventricular dysfunction | HeartEffects of glucose-insulin-potassium infusion on chronic ischaemic left ventricular dysfunction | Heart
Left ventricular dysfunction is a major determinant of outcome in coronary artery disease.1 However, not all dyssynergic areas are irreversibly damaged after infarction, as left ventricular dysfunction may be caused by myocardial stunning2 or by chronic reduction of blood flow,3 and the segments involved may show improved function after restoration of blood flow.4 Preservation of metabolism despite reduced function is the cornerstone of viable myocardium, but ultrastructural changes have been documented in viable tissue, including loss of sarcoplasmic reticulum, small scattered mitochondria, and glycogen deposition.5 These changes suggest a reduction in aerobic metabolism, but glucose uptake and utilisation are preserved and indeed have been used as a diagnostic marker of viability.6. Because of co-morbidity, myocardial revascularisation may be difficult to achieve in many patients with left ventricular dysfunction and viable myocardium. In these situations, medical treatment to improve left ...
Banks designated for assignment | Houston AstrosBanks designated for assignment | Houston Astros
ARLINGTON -- Astros catcher Humberto Quintero had seen enough fowl play. "It was taking too long," he said. Quintero was on deck in the ninth inning of Sundays game against the Rangers when a curious bird landed near home plate for the second time in a matter of minutes. Astros batter Chris Johnson tried to shoo it away with his bat and plate umpire Mike Reilly couldnt get it to budge, either. Thats when Quintero took over, approaching the bird and gently picking it up with both hands. He placed it in a camera well at the end of the first-base dugout, drawing cheers from the crowd. "We have birds in Venezuela," said Quintero, who likes to hunt and was wearing batting gloves. "Why were people scared? We have a lot of birds in Venezuela. I got it and put it away. I didnt want to wait 30 minutes for the bird to go away." Johnson was impressed with Quinteros bird-handling ability. "It looked like hes done that before," Johnson said. "Thats not something you see every day, so I was just trying ...
June | 2012June | 2012
Septic myocardial dysfunction is a well recognised contributor to shock in sepsis but for many of us we assume this to be gross systolic impairment. Interestingly a recent study highlights that patients with severe sepsis and septic shock frequently have diastolic dysfunction1. They found that diastolic dysfunction was the strongest independent predictor of early mortality, even after adjusting for the APACHE-II score and other predictors of mortality.. In this study, 9.1% of severe sepsis/septic shock patients had isolated systolic dysfunction, 14.1% had combined systolic and diastolic dysfunction, and 38% had isolated diastolic dysfunction.. Importantly, the authors point out that although diastolic dysfunction is associated with age, hypertension, diabetes mellitus, and ischaemic heart disease, diastolic dysfunction is a stronger independent predictor of mortality than age and the other co-morbidities. However, a limitation of the study acknowledged by the authors is that it did not include ...
Diastolic dysfunction brings on heart failure | Health24Diastolic dysfunction brings on heart failure | Health24
A common form of heart trouble called diastolic dysfunction appears to worsen over time and may lead to an increased risk of heart failure, new research shows.
Chapter 2. Heart Failure | Pharmacotherapy in Primary Care | AccessPharmacy | McGraw-Hill MedicalChapter 2. Heart Failure | Pharmacotherapy in Primary Care | AccessPharmacy | McGraw-Hill Medical
diaphragm. Orthopnea is relieved by sitting upright and typically is prevented by elevating the head with pillows. PND is a result of severe pulmonary and bronchial congestion and refers to severe shortness of breath and coughing that generally occurs after 2 to 4 hours of sleep; patients awaken with a sense of suffocation.3 The period between the initiation of ventricular dysfunction and the onset of symptoms may occur very quickly after a ...
Systolic DysfunctionSystolic Dysfunction
This page includes the following topics and synonyms: Systolic Dysfunction, Left Ventricular Dysfunction, Left Ventricular Failure, Systolic Heart Failure, Left Ventricular Systolic Dysfunction, Heart Failure with Reduced Ejection Fraction.
St. Patricks Green SmoothieSt. Patrick's Green Smoothie
This St. Patricks Day, skip the green-tinged beer and instead drink to your health with this green smoothie created by Teresa Quintero, Wilcox Memorial Hospital clinical registered dietitian.. "Smoothies can be an easy way to get more fruits and vegetables into your diet," says Quintero. "They can be used as a snack, or they can replace a meal if youre in a rush so you dont skip it. They can even make for excellent recovery fuel post workouts.". Quintero came up with this green smoothie as a deliciously sneaky way to pack more calories and nutrients into her 7-year-olds diet.. "This green smoothie is definitely kid approved! It is an excellent source of vitamins A and C, iron, and is a good source of calcium," she says.. But be careful with your ingredients, and watch those portions!. Quintero advises using a green, leafy vegetable - such as kale, spinach or lettuce - as your base and building on with fruits, nuts, seeds and other add-ons sparingly.. A low-fat, low-sugar milk alternative, ...
Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism - Fingerprint - Arizona...Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism - Fingerprint - Arizona...
Fingerprint Dive into the research topics of Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. Together they form a unique fingerprint. ...
arer - Caught in the Crossfirearer - Caught in the Crossfire
Quartersnacks have re-edited a bunch of random seen and unseen footage of Zered Bassett this week featuring footage filmed by R.B. Umali, Joe Bouillot, Jason Jenkins, Steve Marino and Richard Quintero. "Just think of it as a post-State of Mind part." Press play for Edit of the Week.. ...
Frank-Starling lawFrank-Starling law
Omecamtiv mecarbilOmecamtiv mecarbil
LVSDLVSD
Heart failureHeart failure
HIV associated cardiomyopathyHIV associated cardiomyopathy
Restrictive cardiomyopathyRestrictive cardiomyopathy
ImatinibImatinib
Beta blockerBeta blocker
Pathophysiology of heart failurePathophysiology of heart failure
NisoldipineNisoldipine
Peter Hurley (doctor)Peter Hurley (doctor)
DofetilideDofetilide
Pulmonary embolismPulmonary embolism
Right heart strainRight heart strain
ACE inhibitorACE inhibitor
Hypoplastic left heart syndromeHypoplastic left heart syndrome
Liquid ventilatorLiquid ventilator
Doxorubicin cardiotoxicityDoxorubicin cardiotoxicity
SarafotoxinSarafotoxin
Ischemic cardiomyopathyIschemic cardiomyopathy
ShuntCheckShuntCheck
DesmoplakinDesmoplakin
Pulmonary edemaPulmonary edema
NPR3NPR3
EnalaprilEnalapril
Complications of hypertensionComplications of hypertension
CXCL11CXCL11
Aortic insufficiencyAortic insufficiency
Septic shockSeptic shock
LMNA - 维基百科，自由的百科全书LMNA - 维基百科，自由的百科全书
Intraparenchymal hemorrhageIntraparenchymal hemorrhage
ProteasomeProteasome
Epigenetics of neurodegenerative diseasesEpigenetics of neurodegenerative diseases
DomperidoneDomperidone
VasospasmVasospasm
Leigh syndromeLeigh syndrome
Heart valveHeart valve
Hypertensive emergencyHypertensive emergency
Mioglobina, a enciclopedia libreMioglobina, a enciclopedia libre
Atrial fibrillationAtrial fibrillation
AnalgesicAnalgesic
Intensive care medicineIntensive care medicine
Exercise-induced pulmonary hemorrhageExercise-induced pulmonary hemorrhage
SepsisSepsis
AppetiteAppetite
CADASILCADASIL
Nitric oxide synthaseNitric oxide synthase
Sinus tachycardiaSinus tachycardia
Medical ultrasoundMedical ultrasound
AppetiteAppetite
ಹೃದಯಾಘಾತ - ವಿಕಿಪೀಡಿಯಹೃದಯಾಘಾತ - ವಿಕಿಪೀಡಿಯ
Athari za muda mrefu za pombe, kamusi elezo huruAthari za muda mrefu za pombe, kamusi elezo huru
Schizophreniform disorderSchizophreniform disorder
OxytocinOxytocin
OxymatrineOxymatrine
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ComorbidityComorbidity
Contrast-enhanced ultrasoundContrast-enhanced ultrasound
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceHealth Care
Ventricular Dysfunction, LeftVentricular DysfunctionVentricular Dysfunction, RightStroke VolumeEchocardiographyHeart FailureVentricular Function, LeftNatriuretic Peptide, BrainCardiomyopathiesRadionuclide VentriculographyHemodynamicsMyocardial InfarctionMyocardial ContractionElectrocardiographyMyocardiumVentricular RemodelingErectile DysfunctionMyocardial StunningCardiomyopathy, DilatedHeartSystoleHeart VentriclesDobutamineMyocardial IschemiaEchocardiography, DopplerCardiotonic AgentsDiastoleTreatment OutcomeTakotsubo CardiomyopathyFollow-Up StudiesMitral Valve InsufficiencyAngiotensin-Converting Enzyme InhibitorsTime FactorsPrognosisEnalaprilPredictive Value of TestsProspective StudiesThallium RadioisotopesBiological MarkersVentricular Function, RightPulmonary EmbolismCoronary Artery BypassCoronary DiseaseExercise TestCardiac Output, LowTomography, Emission-Computed, Single-PhotonTransposition of Great VesselsDisease Models, AnimalSeverity of Illness IndexHeart DiseasesCoronary CirculationChronic DiseaseVentricular PressureMyocardial RevascularizationTissue SurvivalRisk FactorsArrhythmias, CardiacDefibrillators, ImplantableAtrial Natriuretic FactorRetrospective StudiesBlood PressureHeart Function TestsHeart RateHypertrophy, Left VentricularCardiac Pacing, ArtificialCardiac CatheterizationAortic Valve StenosisDogsTachycardia, VentricularVasodilator AgentsPreexisting Condition CoveragePulmonary Wedge PressureAdrenergic beta-AntagonistsCardiac VolumeCardiomegalyAtrial PressureRisk AssessmentAortic ValveHypertension, PulmonaryDeath, Sudden, CardiacSensitivity and SpecificityMyocytes, CardiacFibrosisTroponin ICoronary AngiographyEndocardial FibroelastosisAutonomic Nervous System DiseasesCardiac OutputAnti-Arrhythmia AgentsIntra-Aortic Balloon PumpingSurvival RateCoronary Artery DiseaseSexual Dysfunction, PhysiologicalMitral ValveAcute DiseaseEchocardiography, StressSurvival AnalysisCardiopulmonary BypassGated Blood-Pool ImagingHeart AtriaMyocarditisTechnetium Tc 99m SestamibiMilrinoneCase-Control StudiesPostoperative ComplicationsExercise ToleranceDouble-Blind MethodAnalysis of VarianceROC CurveMultivariate AnalysisSexual Dysfunctions, PsychologicalOxidative StressDiabetic CardiomyopathiesChagas CardiomyopathyAortic Valve InsufficiencyCardiac Surgical ProceduresHeart Valve ProsthesisEndomyocardial FibrosisTachycardia3-IodobenzylguanidineProportional Hazards ModelsRadionuclide AngiographyPostoperative PeriodChi-Square DistributionTechnetium Tc 99m PyrophosphateCoronary VesselsHeart Valve Prosthesis ImplantationEndothelium, VascularAtrioventricular BlockEchocardiography, Doppler, ColorDisease ProgressionPulmonary ArteryPeptide FragmentsRadiopharmaceuticalsAtrial FibrillationArterial PressureVentricular FunctionTomography, Emission-ComputedRecovery of FunctionHeart-Assist DevicesElectrocardiography, AmbulatoryCardiac Resynchronization TherapyCaptoprilIodobenzenesMice, Inbred C57BLReproducibility of ResultsPropanolaminesHeart TransplantationKaplan-Meier EstimateMagnetic Resonance ImagingDeathCardiovascular AgentsCentral Venous PressureAmiodaroneCohort StudiesObserver VariationAsymptomatic DiseasesHypertensionRats, WistarEchocardiography, Doppler, PulsedRats, Sprague-DawleyOxygen ConsumptionTroponin TDiureticsElectric CountershockEnoximoneXamoterolTricuspid Valve InsufficiencyLinear ModelsTetralogy of FallotMyocardial ReperfusionPuerperal DisordersMineralocorticoid Receptor AntagonistsPostoperative CareSpironolactoneComorbidityVascular ResistanceDipyridamoleSulfonesDilatation, PathologicHospitalizationHeart Failure, SystolicNatriuretic PeptidesMice, TransgenicStatistics, NonparametricAnaerobic ThresholdNitroprussideParasympatholyticsEndothelin-1Myocardial Reperfusion InjuryBlood Flow VelocityMice, KnockoutShock, CardiogenicNitric OxideHeart BlockNorepinephrinePrevalenceDose-Response Relationship, DrugAge FactorsHeart Valve DiseasesRegression Analysis
Heart Failure and Left Ventricular Dysfunction | SpringerLinkHeart Failure and Left Ventricular Dysfunction | SpringerLink
Systolic and Diastolic Right Ventricular Dysfunction | SpringerLinkSystolic and Diastolic Right Ventricular Dysfunction | SpringerLink
Perioperative right ventricular dysfunction.Perioperative right ventricular dysfunction.
Right Ventricular Dysfunction in Asymptomatic Diabetic Patients | Diabetes CareRight Ventricular Dysfunction in Asymptomatic Diabetic Patients | Diabetes Care
Right Ventricular Dysfunction and Failure in Chronic Pressure OverloadRight Ventricular Dysfunction and Failure in Chronic Pressure Overload
Right Ventricular Dysfunction in Asymptomatic Diabetic Patients | Diabetes CareRight Ventricular Dysfunction in Asymptomatic Diabetic Patients | Diabetes Care
Tako-Tsubo-Like Left Ventricular Dysfunction | CirculationTako-Tsubo-Like Left Ventricular Dysfunction | Circulation
Prevalence of Asymptomatic Ventricular Dysfunction - Full Text View - ClinicalTrials.govPrevalence of Asymptomatic Ventricular Dysfunction - Full Text View - ClinicalTrials.gov
Lotensin User Reviews for Left Ventricular Dysfunction at Drugs.comLotensin User Reviews for Left Ventricular Dysfunction at Drugs.com
Left Ventricular Dysfunction | GreenMedInfo | Disease | NaturalLeft Ventricular Dysfunction | GreenMedInfo | Disease | Natural
Upregulation of Soluble HLA-G in Chronic Left Ventricular Systolic DysfunctionUpregulation of Soluble HLA-G in Chronic Left Ventricular Systolic Dysfunction
β Thalassaemia major and severe left ventricular dysfunction | Heartβ Thalassaemia major and severe left ventricular dysfunction | Heart
Management of right ventricular dysfunction in the perioperative setting.Management of right ventricular dysfunction in the perioperative setting.
Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults | HypertensionLeft Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults | Hypertension
Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults | HypertensionLeft Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults | Hypertension
Myocardial Infarction and Transient Ventricular Dysfunction in an Adolescent With Sickle Cell Disease | American Academy of...Myocardial Infarction and Transient Ventricular Dysfunction in an Adolescent With Sickle Cell Disease | American Academy of...
Ventricular Dysfunction, Left | Harvard Catalyst Profiles | Harvard CatalystVentricular Dysfunction, Left | Harvard Catalyst Profiles | Harvard Catalyst
Natriuretic peptides in assessment of ventricular dysfunction - IFCCNatriuretic peptides in assessment of ventricular dysfunction - IFCC
Abstract 17865: Right Ventricular Diastolic Dysfunction in ABCG2 knockout mice under Hypoxia | CirculationAbstract 17865: Right Ventricular Diastolic Dysfunction in ABCG2 knockout mice under Hypoxia | Circulation
Left ventricular dysfunction: causes, natural history, and hopes for reversal | HeartLeft ventricular dysfunction: causes, natural history, and hopes for reversal | Heart
Measuring brain natriuretic peptide in suspected left ventricular systolic dysfunction in general practice: cross-sectional...Measuring brain natriuretic peptide in suspected left ventricular systolic dysfunction in general practice: cross-sectional...
JCI - Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophyJCI - Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy
PRIME PubMed | Contribution of left ventricular diastolic dysfunction to heart failure regardless of ejection fractioPRIME PubMed | Contribution of left ventricular diastolic dysfunction to heart failure regardless of ejection fractio
Risk assessment of left ventricular systolic dysfunction in primary care: cross sectional study evaluating a range of...Risk assessment of left ventricular systolic dysfunction in primary care: cross sectional study evaluating a range of...
Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular...Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular...
Left atrial dysfunction relates to symptom onset in patients with heart failure and preserved left ventricular ejection...Left atrial dysfunction relates to symptom onset in patients with heart failure and preserved left ventricular ejection...
Opportunistic Screening for Asymptomatic Left Ventricular Dysfunction in Coronavirus Disease 2019 (COVID19) Survivors - Full...Opportunistic Screening for Asymptomatic Left Ventricular Dysfunction in Coronavirus Disease 2019 (COVID19) Survivors - Full...
Sex-specific predictors of left ventricular diastolic dysfunction in u | CIASex-specific predictors of left ventricular diastolic dysfunction in u | CIA
Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis.Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis.
PRIME PubMed | Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial...PRIME PubMed | Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial...
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceHealth Care
Ventricular Dysfunction, LeftVentricular DysfunctionVentricular Dysfunction, RightStroke VolumeEchocardiographyHeart FailureVentricular Function, LeftNatriuretic Peptide, BrainCardiomyopathiesRadionuclide VentriculographyHemodynamicsMyocardial InfarctionMyocardial ContractionElectrocardiographyMyocardiumVentricular RemodelingErectile DysfunctionMyocardial StunningCardiomyopathy, DilatedHeartSystoleHeart VentriclesDobutamineMyocardial IschemiaEchocardiography, DopplerCardiotonic AgentsDiastoleTreatment OutcomeTakotsubo CardiomyopathyFollow-Up StudiesMitral Valve InsufficiencyAngiotensin-Converting Enzyme InhibitorsTime FactorsPrognosisEnalaprilPredictive Value of TestsProspective StudiesThallium RadioisotopesBiological MarkersVentricular Function, RightPulmonary EmbolismCoronary Artery BypassCoronary DiseaseExercise TestCardiac Output, LowTomography, Emission-Computed, Single-PhotonTransposition of Great VesselsDisease Models, AnimalSeverity of Illness IndexHeart DiseasesCoronary CirculationChronic DiseaseVentricular PressureMyocardial RevascularizationTissue SurvivalRisk FactorsArrhythmias, CardiacDefibrillators, ImplantableAtrial Natriuretic FactorRetrospective StudiesBlood PressureHeart Function TestsHeart RateHypertrophy, Left VentricularCardiac Pacing, ArtificialCardiac CatheterizationAortic Valve StenosisDogsTachycardia, VentricularVasodilator AgentsPreexisting Condition CoveragePulmonary Wedge PressureAdrenergic beta-AntagonistsCardiac VolumeCardiomegalyAtrial PressureRisk AssessmentAortic ValveHypertension, PulmonaryDeath, Sudden, CardiacSensitivity and SpecificityMyocytes, CardiacFibrosisTroponin ICoronary AngiographyEndocardial FibroelastosisAutonomic Nervous System DiseasesCardiac OutputAnti-Arrhythmia AgentsIntra-Aortic Balloon PumpingSurvival RateCoronary Artery DiseaseSexual Dysfunction, PhysiologicalMitral ValveAcute DiseaseEchocardiography, StressSurvival AnalysisCardiopulmonary BypassGated Blood-Pool ImagingHeart AtriaMyocarditisTechnetium Tc 99m SestamibiMilrinoneCase-Control StudiesPostoperative ComplicationsExercise ToleranceDouble-Blind MethodAnalysis of VarianceROC CurveMultivariate AnalysisSexual Dysfunctions, PsychologicalOxidative StressDiabetic CardiomyopathiesChagas CardiomyopathyAortic Valve InsufficiencyCardiac Surgical ProceduresHeart Valve ProsthesisEndomyocardial FibrosisTachycardia3-IodobenzylguanidineProportional Hazards ModelsRadionuclide AngiographyPostoperative PeriodChi-Square DistributionTechnetium Tc 99m PyrophosphateCoronary VesselsHeart Valve Prosthesis ImplantationEndothelium, VascularAtrioventricular BlockEchocardiography, Doppler, ColorDisease ProgressionPulmonary ArteryPeptide FragmentsRadiopharmaceuticalsAtrial FibrillationArterial PressureVentricular FunctionTomography, Emission-ComputedRecovery of FunctionHeart-Assist DevicesElectrocardiography, AmbulatoryCardiac Resynchronization TherapyCaptoprilIodobenzenesMice, Inbred C57BLReproducibility of ResultsPropanolaminesHeart TransplantationKaplan-Meier EstimateMagnetic Resonance ImagingDeathCardiovascular AgentsCentral Venous PressureAmiodaroneCohort StudiesObserver VariationAsymptomatic DiseasesHypertensionRats, WistarEchocardiography, Doppler, PulsedRats, Sprague-DawleyOxygen ConsumptionTroponin TDiureticsElectric CountershockEnoximoneXamoterolTricuspid Valve InsufficiencyLinear ModelsTetralogy of FallotMyocardial ReperfusionPuerperal DisordersMineralocorticoid Receptor AntagonistsPostoperative CareSpironolactoneComorbidityVascular ResistanceDipyridamoleSulfonesDilatation, PathologicHospitalizationHeart Failure, SystolicNatriuretic PeptidesMice, TransgenicStatistics, NonparametricAnaerobic ThresholdNitroprussideParasympatholyticsEndothelin-1Myocardial Reperfusion InjuryBlood Flow VelocityMice, KnockoutShock, CardiogenicNitric OxideHeart BlockNorepinephrinePrevalenceDose-Response Relationship, DrugAge FactorsHeart Valve DiseasesRegression Analysis
EjectionEchocardiographyDiastolic functionPrevalenceHeart FailureAssociated with left ventricular dysfunctionLVEFPulmonaryMyocardial infarctionAbstractFunctionEchocardiographicAtrialMethodsSevereAbnormal left ventricularTreatment of acute right ventricularCardiac dysfunctionCoronaryClinicalLVDDHypertensionContractilitySubclinical LV dysfunctionMortality
Ejection34
Echocardiography20
Diastolic function11
Prevalence12
Heart Failure41
Associated with left ventricular dysfunction1
  • Additionally, the Report highlights the frontrunners, the drivers and barriers for the Left Ventricular Dysfunction market, as well as treatment algorithm, current treatments & advancements are included.The chapters including marketed products highlights the advantages and disadvantages associated with therapies associated with Left Ventricular Dysfunction , providing an in-depth analysis of emerging therapies which will create an impact through their launch. (rnrmarketresearch.com)
LVEF2
  • A normal LVEF response during exercise was shown in only 5 of the patients with normal resting left ventricular function. (annals.org)
  • Children who had undergone BAV for AVS and LV dysfunction within the age range of six to 192 months showed a significant reduction in peak-to-peak pressure gradient (PPG) from 73.5 ± 30 mmHg to 26.7 ± 6.7 mmHg and improvement in LVEF from 32.8 ± 11% to 54.3 ± 12.7% after 24 hours. (cureus.com)
Pulmonary26
Myocardial infarction11
Abstract3
Function39
Echocardiographic1
Atrial1
Methods1
  • Methods to better diagnose RV dysfunction earlier and treatments specifically designed to minimize or reverse the remodeling process are likely to improve outcomes. (hindawi.com)
Severe7
Abnormal left ventricular1
  • Despite the substantial differences in the EF, Both groups have reductions in exercise tolerance, neurohumoral activation, and abnormal left ventricular (LV) filling dynamics and impaired relaxation and have similar clinical symptoms and signs. (thefreelibrary.com)
Treatment of acute right ventricular2
Cardiac dysfunction7
Coronary3
Clinical7
LVDD4
Hypertension3
Contractility2
Subclinical LV dysfunction3
Mortality1
Perjeta (Pertuzumab): Uses, Dosage, Side Effects, Interactions, Warning
Perjeta (Pertuzumab): Uses, Dosage, Side Effects, Interactions, Warning (rxlist.com)
Heart Failure and Left Ventricular Dysfunction | SpringerLink
Heart Failure and Left Ventricular Dysfunction | SpringerLink (link.springer.com)
Systolic and Diastolic Right Ventricular Dysfunction | SpringerLink
Systolic and Diastolic Right Ventricular Dysfunction | SpringerLink (link.springer.com)
Vasotec (Enalapril): Side Effects, Interactions, Warning, Dosage & Uses
Vasotec (Enalapril): Side Effects, Interactions, Warning, Dosage & Uses (rxlist.com)
Carvedilol (Coreg, Coreg CR): Side Effects, Dosages, Treatment, Interactions, Warnings
Carvedilol (Coreg, Coreg CR): Side Effects, Dosages, Treatment, Interactions, Warnings (rxlist.com)
ENALAPRIL MALEATE TABLETS USP, 2.5 mg, 5 mg, 10 mg and 20 mg0026002700280029Rx only
ENALAPRIL MALEATE TABLETS USP, 2.5 mg, 5 mg, 10 mg and 20 mg0026002700280029Rx only (dailymed.nlm.nih.gov)
Right Ventricular Dysfunction in Asymptomatic Diabetic Patients | Diabetes Care
Right Ventricular Dysfunction in Asymptomatic Diabetic Patients | Diabetes Care (care.diabetesjournals.org)
Propylhexedrine-Induced Left Ventricular Dysfunction | Annals of Internal Medicine | American College of Physicians
Propylhexedrine-Induced Left Ventricular Dysfunction | Annals of Internal Medicine | American College of Physicians (annals.org)
Left Ventricular Dysfunction | GreenMedInfo | Disease | Natural
Left Ventricular Dysfunction | GreenMedInfo | Disease | Natural (greenmedinfo.com)
Health Information Center
Health Information Center (healthlibrary.epnet.com)
Western-style diets rich in sugar, key factor of heart failure: Study
Western-style diets rich in sugar, key factor of heart failure: Study (in.news.yahoo.com)
Captopril | Side Effects, Dosage, Uses, and More
Captopril | Side Effects, Dosage, Uses, and More (healthline.com)
DailyMed - CARVEDILOL - carvedilol tablet, film coated
DailyMed - CARVEDILOL - carvedilol tablet, film coated (dailymed.nlm.nih.gov)
These highlights do not include all the information needed to use CARVEDILOL TABLETS safely and effectively. See full...
These highlights do not include all the information needed to use CARVEDILOL TABLETS safely and effectively. See full... (dailymed.nlm.nih.gov)
Announcing New Pipeline-to-Pilot Awardees - University of Rochester Medical Center
Announcing New Pipeline-to-Pilot Awardees - University of Rochester Medical Center (urmc.rochester.edu)
Systemic Scleroderma Cardiac (Heart) Involvement
Systemic Scleroderma Cardiac (Heart) Involvement (sclero.org)
April 1985 - Volume 31 - Issue 1 : ASAIO Journal
April 1985 - Volume 31 - Issue 1 : ASAIO Journal (journals.lww.com)
Development of screening echocardiogram for detection of asymptom...: Ingenta Connect
Development of screening echocardiogram for detection of asymptom...: Ingenta Connect (ingentaconnect.com)
Scott Cowan
Scott Cowan (renalandurologynews.com)
Mavik Dosage Guide - Drugs.com
Mavik Dosage Guide - Drugs.com (drugs.com)
Cardiovascular research
Cardiovascular research (guysandstthomas.nhs.uk)
ADDING MULTIMEDIA - ENHERTU® Approved in the U.S. for the Treatment of Patients with Previously Treated HER2 Positive Advanced...
ADDING MULTIMEDIA - ENHERTU® Approved in the U.S. for the Treatment of Patients with Previously Treated HER2 Positive Advanced... (businesswire.com)
TPLC - Total Product Life Cycle
TPLC - Total Product Life Cycle (accessdata.fda.gov)
Compound Report Card
Compound Report Card (ebi.ac.uk)
TYROSINE KINASE INHIBITORS
TYROSINE KINASE INHIBITORS (slideshare.net)
Rosen's pediatric fever - English
Rosen's pediatric fever - English (slideshare.net)
Immune Dysfunction and Immunotherapy in Heart Disease | Cardiovascular Disease | Medicine, Nursing & Dentistry | Subjects |...
Immune Dysfunction and Immunotherapy in Heart Disease | Cardiovascular Disease | Medicine, Nursing & Dentistry | Subjects |... (wiley.com)