Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
Specific molecular sites or proteins on or in cells to which VASOPRESSINS bind or interact in order to modify the function of the cells. Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. The V1 receptor can be subdivided into V1a and V1b (formerly V3) receptors.
A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.
A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
A mutant strain of Rattus norvegicus used in research on renal function and hypertension and as a disease model for diabetes insipidus.
The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
Carrier proteins for OXYTOCIN and VASOPRESSIN. They are polypeptides of about 10-kDa, synthesized in the HYPOTHALAMUS. Neurophysin I is associated with oxytocin and neurophysin II is associated with vasopressin in their respective precursors and during transportation down the axons to the neurohypophysis (PITUITARY GLAND, POSTERIOR).
Drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.
A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.
Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.
A nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.
Agents that reduce the excretion of URINE, most notably the octapeptide VASOPRESSINS.
Hypothalamic nucleus overlying the beginning of the OPTIC TRACT.
Aquaporin 2 is a water-specific channel protein that is expressed in KIDNEY COLLECTING DUCTS. The translocation of aquaporin 2 to the apical PLASMA MEMBRANE is regulated by VASOPRESSIN, and MUTATIONS in AQP2 have been implicated in a variety of kidney disorders including DIABETES INSIPIDUS.
Hormones released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). They include a number of peptides which are formed in the NEURONS in the HYPOTHALAMUS, bound to NEUROPHYSINS, and stored in the nerve terminals in the posterior pituitary. Upon stimulation, these peptides are released into the hypophysial portal vessel blood.
Straight tubes commencing in the radiate part of the kidney cortex where they receive the curved ends of the distal convoluted tubules. In the medulla the collecting tubules of each pyramid converge to join a central tube (duct of Bellini) which opens on the summit of the papilla.
The withholding of water in a structured experimental situation.
An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.
Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.
Aquaporin 6 is an aquaglyceroporin that is found primarily in KIDNEY COLLECTING DUCTS. AQP6 protein functions as an anion-selective channel.
The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.
Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced.
The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.
The ability of the kidney to excrete in the urine high concentrations of solutes from the blood plasma.
A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to renal tubular insensitivity to VASOPRESSIN and failure to reduce urine volume. It may be the result of mutations of genes encoding VASOPRESSIN RECEPTORS or AQUAPORIN-2; KIDNEY DISEASES; adverse drug effects; or complications from PREGNANCY.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Nucleus in the anterior part of the HYPOTHALAMUS.
A drive stemming from a physiological need for WATER.
Drugs used to cause constriction of the blood vessels.
Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Cell surface proteins that bind ANGIOTENSINS and trigger intracellular changes influencing the behavior of cells.
Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
A class of porins that allow the passage of WATER and other small molecules across CELL MEMBRANES.
The condition that results from excessive loss of water from a living organism.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
Compounds with BENZENE fused to AZEPINES.
Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Injections into the cerebral ventricles.
A synthetic analog of vasopressin with ORNITHINE substitution at residue 8 of the cyclic nonapeptide. It is used as a local vasoconstrictor and hemostatic.
A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
The front portion of the HYPOTHALAMUS separated into the preoptic region and the supraoptic region. The preoptic region is made up of the periventricular GRAY MATTER of the rostral portion of the THIRD VENTRICLE and contains the preoptic ventricular nucleus and the medial preoptic nucleus. The supraoptic region contains the PARAVENTRICULAR HYPOTHALAMIC NUCLEUS, the SUPRAOPTIC NUCLEUS, the ANTERIOR HYPOTHALAMIC NUCLEUS, and the SUPRACHIASMATIC NUCLEUS.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Tendency of fluids (e.g., water) to move from the less concentrated to the more concentrated side of a semipermeable membrane.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
The consumption of liquids.
A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.
A genetic or acquired polyuric disorder caused by a deficiency of VASOPRESSINS secreted by the NEUROHYPOPHYSIS. Clinical signs include the excretion of large volumes of dilute URINE; HYPERNATREMIA; THIRST; and polydipsia. Etiologies include HEAD TRAUMA; surgeries and diseases involving the HYPOTHALAMUS and the PITUITARY GLAND. This disorder may also be caused by mutations of genes such as ARVP encoding vasopressin and its corresponding neurophysin (NEUROPHYSINS).
The relationship between the dose of an administered drug and the response of the organism to the drug.
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
Excessive amount of sodium in the blood. (Dorland, 27th ed)
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The production and release of substances such as NEUROTRANSMITTERS or HORMONES from nerve cells.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
Sodium excretion by URINATION.
An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.
In animals, the social relationship established between a male and female for reproduction. It may include raising of young.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.
Fluids composed mainly of water found within the body.
Phosphoric acid esters of inositol. They include mono- and polyphosphoric acid esters, with the exception of inositol hexaphosphate which is PHYTIC ACID.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.
A species of the true toads, Bufonidae, becoming fairly common in the southern United States and almost pantropical. The secretions from the skin glands of this species are very toxic to animals.
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.
The active form of GLYCOGEN PHOSPHORYLASE that is derived from the phosphorylation of PHOSPHORYLASE B. Phosphorylase a is deactivated via hydrolysis of phosphoserine by PHOSPHORYLASE PHOSPHATASE to form PHOSPHORYLASE B.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
Elements of limited time intervals, contributing to particular results or situations.
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
Raised area at the infundibular region of the HYPOTHALAMUS at the floor of the BRAIN, ventral to the THIRD VENTRICLE and adjacent to the ARCUATE NUCLEUS OF HYPOTHALAMUS. It contains the terminals of hypothalamic neurons and the capillary network of hypophyseal portal system, thus serving as a neuroendocrine link between the brain and the PITUITARY GLAND.
A class of glucosyltransferases that catalyzes the degradation of storage polysaccharides, such as glucose polymers, by phosphorolysis in animals (GLYCOGEN PHOSPHORYLASE) and in plants (STARCH PHOSPHORYLASE).

Vasopressin stimulation of acetate incorporation into lipids in a dimethylbenz(a)anthracene-induced rat mammary tumor cell line. (1/2313)

In a preliminary report we described the effects of rat prolactin on the incorporation of [14C]acetate into lipids by a cell line from a dimethylbenz(a)anthracene-induced rat mammary tumor. The characteristics of the response to prolactin were very similar to those described for the normal rat mammary gland; namely, insulin was required for full expression of the response, maximal activity was not seen until 36 hr after the addition of the hormones, and growth hormone was able to elicit the same response. However, we were unable to detect binding of 125I-labeled prolactin to these cells, and furthermore, other more purified prolactin preparations were inactive. Upon further investigation we discovered that the activity resided in a low-molecular-weight fraction of the rat prolactin B-1 preparation and was probably either vasopressin or oxytocin or both. These data suggest the possibility that vasopressin may play a role in rodent mammary tumorigenesis.  (+info)

Evidence for a vasopressin system in the rat heart. (2/2313)

Traditionally, a hypothalamo-neurohypophysial system is thought to be the exclusive source of arginine vasopressin (AVP), a potent antidiuretic, vasoconstricting, and growth-stimulating neuropeptide. We have identified de novo synthesis of AVP in the heart as well as release of the hormone into the cardiac effluents. Specifically, molecular cloning of sequence tags amplified from isolated, buffer-perfused, and pressure-overloaded rat hearts allowed the detection of cardiac AVP mRNA. Subsequent experiments revealed a prominent induction of AVP mRNA (peak at 120 minutes, 59-fold, P<0. 01 versus baseline) and peptide (peak at 120 minutes, 11-fold, P<0. 01 versus baseline) in these isolated hearts. Newly induced vasopressin peptide was localized most prominently to endothelial cells and vascular smooth muscle cells of arterioles and perivascular tissue using immunohistochemistry. In addition to pressure overload, nitric oxide (NO) participated in these alterations, because inhibition of NO synthase by Nomega-nitro-L-arginine methyl ester markedly depressed cardiac AVP mRNA and peptide induction. Immediate cardiac effects related to cardiac AVP induction in isolated, perfused, pressure-overloaded hearts appeared to be coronary vasoconstriction and impaired relaxation. These functional changes were observed in parallel with AVP induction and largely prevented by addition of a V1 receptor blocker (10(-8) mol/L [deamino-Pen1, O-Me-Tyr2, Arg8]-vasopressin) to the perfusion buffer. Even more interesting, pressure-overloaded, isolated hearts released the peptide into the coronary effluents, offering the potential for systemic actions of AVP from cardiac origin. We conclude that the heart, stressed by acute pressure overload or NO, expresses vasopressin in concentrations sufficient to cause local and potentially systemic effects.  (+info)

Central peptidergic neurons are hyperactive during collateral sprouting and inhibition of activity suppresses sprouting. (3/2313)

Little is known regarding the effect of chronic changes in neuronal activity on the extent of collateral sprouting by identified CNS neurons. We have investigated the relationship between activity and sprouting in oxytocin (OT) and vasopressin (VP) neurons of the hypothalamic magnocellular neurosecretory system (MNS). Uninjured MNS neurons undergo a robust collateral-sprouting response that restores the axon population of the neural lobe (NL) after a lesion of the contralateral MNS (). Simultaneously, lesioned rats develop chronic urinary hyperosmolality indicative of heightened neurosecretory activity. We therefore tested the hypothesis that sprouting MNS neurons are hyperactive by measuring changes in cell and nuclear diameters, OT and VP mRNA pools, and axonal cytochrome oxidase activity (COX). Each of these measures was significantly elevated during the period of most rapid axonal growth between 1 and 4 weeks after the lesion, confirming that both OT and VP neurons are hyperactive while undergoing collateral sprouting. In a second study the hypothesis that chronic inhibition of neuronal activity would interfere with the sprouting response was tested. Chronic hyponatremia (CH) was induced 3 d before the hypothalamic lesion and sustained for 4 weeks to suppress neurosecretory activity. CH abolished the lesion-induced increases in OT and VP mRNA pools and virtually eliminated measurable COX activity in MNS terminals. Counts of the total number of axon profiles in the NL revealed that CH also prevented axonal sprouting from occurring. These results are consistent with the hypothesis that increased neuronal activity is required for denervation-induced collateral sprouting to occur in the MNS.  (+info)

Why is the retention of gonadotrophin secretion common in children with panhypopituitarism due to septo-optic dysplasia? (4/2313)

Septo-optic dysplasia (De Morsier syndrome) is a developmental anomaly of mid-line brain structures and includes optic nerve hypoplasia, absence of the septum pellucidum and hypothalamo-pituitary abnormalities. We describe seven patients (four female, three male) who had at least two out of the three features necessary for the diagnosis of septo-optic dysplasia. Four patients had hypopituitarism and yet normal gonadotrophin secretion: one of these also had anti-diuretic hormone insufficiency; three had isolated GH deficiency and yet had premature puberty, with the onset of puberty at least a year earlier than would have been expected for their bone age. In any progressive and evolving anterior pituitary lesion it is extremely unusual to lose corticotrophin-releasing hormone/ACTH and TRH/TSH secretion and yet to retain gonadotrophin secretion. GnRH neurons develop in the nasal mucosa and migrate to the hypothalamus in early fetal life. We hypothesise that the arrival of GnRH neurons in the hypothalamus after the development of a midline hypothalamic defect may explain these phenomena. Progress in spontaneous/premature puberty in children with De Morsier syndrome may have important implications for management. The combination of GH deficiency and premature puberty may allow an apparently normal growth rate but with an inappropriately advanced bone age resulting in impaired final stature. GnRH analogues may be a therapeutic option. In conclusion, some patients with De Morsier syndrome appear to retain the ability to secrete gonadotrophins in the face of loss of other hypothalamic releasing factors. The migration of GnRH neurons after the development of the midline defect may be an explanation.  (+info)

Comparison of two aquaretic drugs (niravoline and OPC-31260) in cirrhotic rats with ascites and water retention. (5/2313)

kappa-Opioid receptor agonists (niravoline) or nonpeptide antidiuretic hormone (ADH) V2 receptor antagonists (OPC-31260) possess aquaretic activity in cirrhosis; however, there is no information concerning the effects induced by the chronic administration of these drugs under this condition. To compare the renal and hormonal effects induced by the long-term oral administration of niravoline, OPC-31260, or vehicle, urine volume, urinary osmolality, sodium excretion, and urinary excretion of aldosterone (ALD) and ADH were measured in basal conditions and for 10 days after the daily oral administration of niravoline, OPC-31260, or vehicle to cirrhotic rats with ascites and water retention. Creatinine clearance, serum osmolality, ADH mRNA expression, and systemic hemodynamics were also measured at the end of the study. Niravoline increased water excretion, peripheral resistance, serum osmolality, and sodium excretion and reduced creatinine clearance, ALD and ADH excretion, and mRNA expression of ADH. OPC-31260 also increased water metabolism and sodium excretion and reduced urinary ALD, although the aquaretic effect was only evident during the first 2 days, and no effects on serum osmolality, renal filtration, and systemic hemodynamics were observed. Therefore, both agents have aquaretic efficacy, but the beneficial therapeutic effects of the long-term oral administration of niravoline are more consistent than those of OPC-31260 in cirrhotic rats with ascites and water retention.  (+info)

Stimulus-dependent translocation of kappa opioid receptors to the plasma membrane. (6/2313)

We examined the cellular and subcellular distribution of the cloned kappa opioid receptor (KOR1) and its trafficking to the presynaptic plasma membrane in vasopressin magnocellular neurosecretory neurons. We used immunohistochemistry to show that KOR1 immunoreactivity (IR) colocalized with vasopressin-containing cell bodies, axons, and axon terminals within the posterior pituitary. Ultrastructural analysis revealed that a major fraction of KOR1-IR was associated with the membrane of peptide-containing large secretory vesicles. KOR1-IR was rarely associated with the plasma membrane in unstimulated nerve terminals within the posterior pituitary. A physiological stimulus (salt-loading) that elicits vasopressin release also caused KOR1-IR to translocate from these vesicles to the plasma membrane. After stimulation, there was a significant decrease in KOR1-IR associated with peptide-containing vesicles and a significant increase in KOR1-IR associated with the plasma membrane. This stimulus-dependent translocation of receptors to the presynaptic plasma membrane provides a novel mechanism for regulation of transmitter release.  (+info)

Resistance to hepatic action of vasopressin in genetically obese (ob/ob) mice. (7/2313)

1. Fatty acid synthesis, measured in the perfused liver of genetically obese (ob/ob) mice with 3H2O or [14C]actate, did not show the inhibition by [8-arginine]vasopressin (antidiuretic hormone) that is observed in livers from normal mice. 2. Hepatic glycogen breakdown in obese mice was stimuulated by vasopressin, but not as extensively as in lean mice. 3. If obese mice received a restricted amount of food, then fatty acid synthesis still did not respond to vasopressin, but glycogen breakdown was fully stimulated. 4. Cholesterol synthesis was not inhibited by vasopressin in livers from obese mice. 5. Vasopressin inhibited fatty acid synthesis in intact lean mice, but not in obese animals. 6. These results suggest that genetic obesity could be due to an inborn error within the mechanisms (other than adenylate cyclase) which mediate responses to extracellular effectors.  (+info)

Evidence for calcium inactivation during hormone release in the rat neurohypophysis. (8/2313)

1. A study has been made of the relationship between 45Ca uptake into and hormone release from isolated rat neurohypophyses incubated in vitro. 2. Hormone secretion is triggered by high-K (56 mM) but long exposure to the stimulus does not generate a maintained release of hormone. 3. When hormone release began to wane, addition of Ba of La increased hormone output which suggests that the decline in output did not result from depletion of the neurosecretory granules at the nerve terminals. 4. 45Ca uptake is enhanced in the presence of high-K concentration, but the initial high rate declines during long exposure to the potassium stimulus with a time constant similar to that of the decline in hormone release. 5. After a period of incubation in a K-rich, calcium-free medium, addition of calcium to the medium induced hormone release. The magnitude of this release was dependent on the time of exposure to excess potassium. 6. After inactivation of secretion, mobilization of internal calcium by means of a calcium ionophore increased hormone release.  (+info)

U.S., Jan. 12 -- ClinicalTrials.gov registry received information related to the study (NCT03014063) titled Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock on Jan. 4. Brief Summary: This is a prospective observational cohort trial evaluating a single plasma vasopressin concentration in patients receiving exogenous, adjunctive vasopressin for septic shock. The trial is designed to determine whether plasma vasopressin concentration influences the likelihood of hemodynamic response to exogenous vasopressin therapy. Study Start Date: November 2016 Study Type: Observational Condition: Septic Shock Intervention: Not Provided Recruitment Status: Recruiting Sponsor: The Cleveland Clinic Information provided by (Responsible Party): The Cleveland Clinic ...
1. Plasma concentration of arginine vasopressin, plasma osmolality and packed cell volume were measured in stroke-prone spontaneously hypertensive rats (SHRSP) and in normotensive Wistar-Kyoto (WKY) rats at different ages.. 2. In young and in adolescent SHRSP, at 6, 9 and 12 weeks of age, plasma concentration of vasopressin was diminished as compared with age-matched WKY rats (P , 0.01), whereas, in 18-week-old rats, the difference was not significant (P , 0.05). In contrast, in 24-week-old rats, plasma vasopressin was elevated as compared with WKY rats of the same age (P , 0.01).. 3. In none of the age groups did plasma osmolality differ between the two strains of rats, but in all groups packed cell volume in SHRSP was higher than in WKY rats.. 4. During a 48 h period of dehydration, plasma vasopressin concentrations increased similarly in SHRSP and in WKY rats of 6 and 12 weeks of age respectively.. 5. It is concluded that vasopressin does not contribute to the development of high blood ...
1. Plasma concentration of arginine vasopressin, plasma osmolality and packed cell volume were measured in stroke-prone spontaneously hypertensive rats (SHRSP) and in normotensive Wistar-Kyoto (WKY) rats at different ages.. 2. In young and in adolescent SHRSP, at 6, 9 and 12 weeks of age, plasma concentration of vasopressin was diminished as compared with age-matched WKY rats (P , 0.01), whereas, in 18-week-old rats, the difference was not significant (P , 0.05). In contrast, in 24-week-old rats, plasma vasopressin was elevated as compared with WKY rats of the same age (P , 0.01).. 3. In none of the age groups did plasma osmolality differ between the two strains of rats, but in all groups packed cell volume in SHRSP was higher than in WKY rats.. 4. During a 48 h period of dehydration, plasma vasopressin concentrations increased similarly in SHRSP and in WKY rats of 6 and 12 weeks of age respectively.. 5. It is concluded that vasopressin does not contribute to the development of high blood ...
Khanna, S, Sibbald, JR, Smith, DW and Day, Trevor 1994, Initiation of rat vasopressin cell responses to simulated hypotensive hemorrhage., The American journal of physiology, vol. 267, no. 4 Pt 2, pp. R1142-R1142. ...
DESCRIPTION (provided by applicant): Diabetes and congestive heart failure are diseases that have been associated with defects in the handling of salt and water by the kidney. Common in individuals with these disorders are elevated circulating levels of vasopressin, the peptide hormone that regulates renal water excretion. Circulating vasopressin plays a critical role in extra-cellular fluid expansion and development of hypertension, thus contributes to the pathogenesis of the disease. Vasopressin has clear long-term actions in the kidney, associated with vasopressin receptor activated processes and transcriptional regulation. Circulating vasopressin also increases the concentrating capacity of the renal medulla by activating the counter current mechanism. The result is an increase in medullary osmotic stress that can directly activate renal cell signaling pathways and gene transcription. Thus specific effects of vasopressin on gene expression are not delineated from secondary alterations ...
Water excretion by the kidney is regulated by the peptide hormone vasopressin. Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed from collecting duct urine to blood. Despite long-standing interest in this process, the mechanism of the water permeability increase has remained undetermined. Recently, a molecular water channel (AQP-CD) has been cloned whose expression appears to be limited to the collecting duct. Previously, we immunolocalized this water channel to the apical plasma membrane (APM) and to intracellular vesicles (IVs) of collecting duct cells. Here, we test the hypothesis that vasopressin increases cellular water permeability by inducing exocytosis of AQP-CD-laden vesicles, transferring water channels from IVs to APM. Rat collecting ducts were perfused in vitro to determine water permeability and subcellular distribution of AQP-CD in the same tubules. The collecting ducts were fixed for immunoelectron microscopy ...
TY - JOUR. T1 - Endogenous vasopressin and renin-angiotensin systems support blood pressure after epidural block in humans. AU - Carp, H.. AU - Vadhera, Rakesh. AU - Jayaram, A.. AU - Garvey, D.. PY - 1994. Y1 - 1994. N2 - Background: Studies in experimental animals show that endogenous Arg- vasopressin (AVP) and the renin-angiotensin system support blood pressure when the sympathetic system is impaired pharmacologically or after epidural anesthesia. However, extrapolation to humans is uncertain. Therefore, we administered an AVP type V1 receptor antagonist and an angiotensin- converting enzyme inhibitor to volunteers and measured the effect on blood pressure after epidural anesthesia. Methods: Healthy volunteers in whom epidural catheters were placed were randomly assigned to receive 1.25 mg intravenous enalapril or saline placebo followed by 0.5 mg AVP type V1 antagonist β-mercapto-β,β-cyclopentamethylene-proprionyl-o-Met-Tyr-Arg- vasopressin (AVPA) or saline placebo. Finally, 2% lidocaine ...
Lysine vasopressin (antidiuretic hormone), like cyclic adenosine 3,5-monophosphate (cyclic AMP), rapidly (in less than 1 hour) stimulates the initiation of deoxyribonucleic acid synthesis and thereby increases the flow of cells into mitosis in rat thymic lymphocyte populations in vitro. This mitogenic action of vasopressin, again like that of cyclic AMP, is potentiated by caffeine, an inhibitor of the intracellular phosphodiesterase which catalyzes the degradation of cyclic AMP. On the other hand, vasopressins mitogenic action (also like that of cyclic AMP) is blocked by imidazole, an activator of cyclic nucleotide phosphodiesterase activity. The hormone, thyrocalcitonin (calcitonin) which is known to block the cyclic AMP-mediated mitogenic effect of parathyroid hormone by interfering with cyclic AMP action, also blocks the mitogenic action of vasopressin. The inhibitory effects of imidazole and thyrocalcitonin on vasopressins mitogenic action are both overcome by the phosphodiesterase inhibitor
Viral vector methods have been routinely used as a means to deliver genes into the nervous system in vivo, and have been very effectively used for gene transfer...
STUDY OBJECTIVE: To investigate the early blood pressure effects of vasopressin compared with titrated catecholamines as initial drug therapy in patients with septic shock.. DESIGN: Retrospective cohort, single-center study.. SETTING: Intensive care units at the Mayo Clinic, Rochester, Minnesota.. PATIENTS: Fifty, 49, and 51 intensive care patients treated initially with vasopressin, norepinephrine, and dopamine, respectively.. INTERVENTION: Patients received either intravenous infusion of fixed-dose vasopressin 0.04 U/minute or titrated infusions of norepinephrine or dopamine for low systemic arterial pressures.. MEASUREMENTS AND MAIN RESULTS: Patients treated with vasopressin, norepinephrine, and dopamine were similar in all measured characteristics except for their score on the Acute Physiology and Chronic Health Evaluation (APACHE) III (dopamine , vasopressin, p=0.049), renal comorbidities (dopamine , vasopressin, p=0.03) and baseline mean arterial pressure (MAP) (norepinephrine , ...
Inhospital cardiac arrest still constitutes an important clinical problem with survival to discharge ranging within 0-42% (most common range = 15-20%). Survival after witnessed, pulseless ventricular fibrillation/tachycardia(VF/VT) that is responsive to one or two direct current countershock(s) may exceed 30%. However, survival after inhospital asystole, pulseless electrical activity, or refractory VF/VT (defined as not responsive to two countershocks) may be substantially lower (, 5-10%). As in nonsurvivors, both endogenous vasopressin and adrenocorticotrophin are reduced compared to survivors, we hypothesized that the addition of exogenous vasopressin and steroids to the standard CPR protocol may increase the rates of both the return of spontaneous circulation (ROSC) and of post-arrest survival. The mechanistic basis of this hypothesis comprises the simultaneous activation of adrenergic and vasopressin receptors, in conjunction with a potential steroid-mediated enhancement of the vascular ...
TY - JOUR. T1 - Activation of vasopressin neurons leads to phenotype progression in a mouse model for familial neurohypophysial diabetes insipidus. AU - Hiroi, Maiko. AU - Morishita, Yoshiaki. AU - Hayashi, Masayuki. AU - Ozaki, Nobuaki. AU - Sugimura, Yoshihisa. AU - Nagasaki, Hiroshi. AU - Shiota, Akira. AU - Oiso, Yutaka. AU - Arima, Hiroshi. PY - 2010/2/1. Y1 - 2010/2/1. N2 - Familial neurohypophysial diabetes insipidus (FNDI) is a rare disease that is inherited in an autosomal dominant manner. In a previous study, we made a mouse model for FNDI, which showed progressive polyuria accompanied by inclusion bodies in the arginine vasopressin (AVP) neurons formed by aggregates in the endoplasmic reticulum. The present study was conducted to determine whether the activities of AVP neurons are related to the phenotype progression in the FNDI model. In the first experiment, female heterozygous mice were administered either desmopressin (dDAVP) or a vehicle (control) subcutaneously with osmotic ...
TY - JOUR. T1 - Mechanism of the inhibition of protein synthesis by vasopressin in rat liver. AU - Kimball, S. R.. AU - Jefferson, L. S.. PY - 1990. Y1 - 1990. N2 - A recent study reported that protein synthesis was inhibited in rat livers perfused with medium containing vasopressin (Chin, K.-V., Cade, C., Brostrom, M. A., and Brostrom, C. O. (1988) Int. J. Biochem. 20, 1313-1319). The inhibition of protein synthesis caused by vasopressin was associated with a disaggregation of polysomes, suggesting that peptide chain initiation was slowed relative to elongation. In contrast, Redpath and Proud (Redpath, N. T., and Proud, C. G. (1989) Biochem. J. 262, 69-75) recently reported an inhibition of peptide chain elongation by a calcium/calmodulin-dependent mechanism. Therefore, the question remained whether only peptide chain initiation was inhibited or both initiation and elongation were affected by vasopressin. In the present study, vasopressin was found to inhibit protein synthesis in both perfused ...
Pitressin (Vasopressin) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.
In this study we found that, in 31 normal subjects, close to 90% of circulating arginine vasopressin (AVP), measured by radioimmunoassay, was associated with platelets. By using routine methods of centrifugation, which do not completely separate platelets, the normal range of plasma vasopressin was higher by twofold than the normal range in platelet-free plasma prepared by differential centrifugation, which was 1.4 +/- 1.0 sd pg/ml. Platelet vasopressin was 12.9 +/- 5.7 pg/ml. Patients with congestive heart failure had, on average, an elevated platelet-free plasma AVP, as did two patients with thrombocytopenia and one with thrombocytosis. Patients with essential hypertension had slightly high levels of platelet-free plasma AVP and demonstrated an abnormal inverse relationship between platelet-free plasma AVP and serum osmolality. Immunoreactive platelet vasopressin was slightly low in patients with essential hypertension and was subnormal in patients with congestive heart failure. These studies ...
Vasopressin is a man-made form of a hormone called anti-diuretic hormone that is normally secreted by the pituitary gland. Vasopressin acts on the kidneys and blood vessels. Vasopressin helps prevent loss of water from the body by reducing urine output and helping the kidneys reabsorb water into the body. Vasopressin...
Definition of vasopressins in the Definitions.net dictionary. Meaning of vasopressins. What does vasopressins mean? Information and translations of vasopressins in the most comprehensive dictionary definitions resource on the web.
Vasopressin in cardiac surgery. There is limited evidence surrounding the use of vasopressin in cardiac surgery. Anecdotally, we use vasopressin, both during cardiopulmonary bypass and after, when patients have refractory shock. We have no idea what impact this intervention has on outcome. One small (unconvincing) study suggests that the addition of vasopressin is not associated with increased predicted mortality associated with cardiac surgery.27 Specifically, and with scant evidence, vasopressin has been advocated for refractory shock in this setting, especially when there is coexisting pulmonary hypertension.28 In early animal studies, vasopressin was shown to cause pulmonary vasodilation. However, in a well-conducted dog study, vasopressin was shown to cause pulmonary vascular constriction and to exert an important negative inotropic effect on the right ventricle.29 This was not the case when phenylephrine was used to augment systemic BP.29 It may be that at high doses vasopressin causes ...
TY - JOUR. T1 - The kidneys stimulate vasopressin release during hemorrhage in rats with chronic NTS lesions. AU - Schreihofer, Ann M.. AU - Hoffman, Gloria E.. AU - Sved, Alan F.. PY - 1997. Y1 - 1997. N2 - Elimination of baroreceptor afferent input to the brain produced by chronic lesion of nucleus of the solitary tract (NTS) does not alter vasopressin (VP) release during hypotensive hemorrhage in conscious rats. To investigate whether the kidneys play a critical role in stimulating VP release during hemorrhage in chronic NTS-lesioned rats, we examined the effects of removing potential signals arising from the kidneys. In NTS- lesioned rats, nephrectomy or renal denervation, but not captopril injection, markedly attenuated (but did not abolish) hemorrhage-induced VP release. In contrast, none of these manipulations attenuated the VP response in NTS- intact rats. Hemorrhage increased plasma renin activity in control and NTS- lesioned rats, and this response was not altered by renal denervation. ...
The neuropeptide Arginine vasopressin (AVP), also known as argipressin or antidiuretic hormone (ADH), is a hormone found in humans. It is mainly released when the body is low on water; it stimulates water reabsorption in the kidneys. It performs diverse actions when released in the brain, and has been implicated in memory formation, aggression, blood pressure regulation, and temperature regulation. Similar vassopressins are found in other mammalian species.. In recent years, there has been particular interest in the role of vasopressin in social behavior. It is thought that vasopressin, released into the brain during sexual activity, initiates and sustains patterns of activity that support the pair-bond between the sexual partners; in particular, vasopressin seems to induce the male to become aggressive towards other males. Evidence for this connection comes from experimental studies on several species which indicate that the precise distribution of vasopressin and vasopressin receptors in the ...
Vasopressin (also, anti-diuretic hormone (ADH) or arginine vasopressin (AVP)) has been shown to be a very effective vasopressor, especially in circumstances…
The mRNA encoding vasopressin has recently been documented within the magnocellular hypothalamo-neurohypophyseal projections of the rat such as the median eminence (ME) and the posterior pituitary (PP), suggesting the possibility of its axonal transport. To address the origin of this mRNA and to investigate the functional significance of this unexpected axonal transport of mRNA, we have examined its subcellular localization within both magnocellular perikarya and their axonal projections. For this purpose, we have used nonradioactive in situ hybridization techniques in order to localize the vasopressin mRNA with precision at the ultrastructural level in magnocellular perikarya, dendrites, and axons from control, salt-loaded, and lactating rats. This approach permitted us to demonstrate directly the axonal localization of vasopressin mRNA. Moreover, we were able to obtain novel information concerning vasopressin mRNA compartmentation within both perikarya and axons. At both light and electron ...
The effect of lowering the pressure of oxygen from 80 to 34 mm Hg was examined in anesthetized dogs that were undergoing a water diuresis. This degree of hypoxia was associated with an antidiuresis as urine osmolality (Uosm) increased from 107 to 316 mosmol/kg H2O (P < 0.001) and plasma arginine vasopressin increased from 0.06 to 7.5 μU/ml, (P < 0.05). However, hypoxia was not associated with significant changes in cardiac output (CO, from 4.2 to 4.7 liters/ min), mean arterial pressure (MAP, from 143 to 149 mm Hg), glomerular filtration rate (GFR, from 46 to 42 ml/min), solute excretion rate (SV, from 302 to 297 mosmol/min), or filtration fraction (from 0.26 to 0.27, NS). Hypoxia was associated with an increase in renal vascular resistance (from 0.49 to 0.58 mm Hg/ml per min, P < 0.01). The magnitude of hypoxia-induced antidiuresis was the same in innervated kidneys and denervated kidneys. To further examine the role of vasopressin in this antidiuresis, hypoxia was induced in hypophysectomized ...
Bevevino, L. H., Procópio, J., Sesso, A., & Sanioto, S. M. L. (1994). Hydrosmotic and natriferic responses of different regions of frog skin and correlation with epithelial structure. In Proceedings. Montevideo: Alacf-Iups ...
Stimulation of hepatocytes with vasopressin evokes increases in cytosolic free Ca2+ ([Ca2+]c) that are relayed into the mitochondria, where the resulting mitochondrial Ca2+ ([Ca2+]m) increase regulates intramitochondrial Ca2+-sensitive targets. To understand how mitochondria integrate the [Ca2+]c signals into a final metabolic response, we stimulated hepatocytes with high vasopressin doses that generate a sustained increase in [Ca2+]c. This elicited a synchronous, single spike of [Ca2+]m and consequent NAD(P)H formation, which could be related to changes in the activity state of pyruvate dehydrogenase (PDH) measured in parallel. The vasopressin-induced [Ca2+]m spike evoked a transient increase in NAD(P)H that persisted longer than the [Ca2+]m increase. In contrast, PDH activity increased biphasically, with an initial rapid phase accompanying the rise in [Ca2+]m, followed by a sustained secondary activation phase associated with a decline in cellular ATP. The decline of NAD(P)H in the face of ...
Autism is a complex neurodevelopmental disorder with no known drug treatment up until now. Researchers have finally found tweaking certain hormones could help patients with autism. There were two independent clinical trials including children and adults with autism that altered the effects of the hormone vasopressin and to assess the effects on social functioning.. ...
Chelko SP, Schmiedt CW, Lewis TH, et al. Vasopressin-induced constriction of the isolated rat occipital artery is segment dependent. J Vasc Res. 2013;50(6):478-85. PMID: 24192548.. Mastropaolo M, Zizzo MG, Auteri M, et al. Arginine vasopressin, via activation of post-junctional V1 receptors, induces contractile effects in mouse distal colon. Regul Pept. 2013 Nov 10;187:29-34. PMID: 24185041.. Salazar M, Hu BB, Vazquez J, et al. Exogenous Vasopressin-Induced Hyponatremia in Patients With Vasodilatory Shock: Two Case Reports and Literature Review. J Intensive Care Med. 2013 Oct 7. [Epub ahead of print]. PMID: 24106070. ...
The history of humankind is an epic of cooperation, which is ubiquitous across societies and increasing in scale. Much human cooperation occurs where it is risky to cooperate for mutual benefit because successful cooperation depends on a sufficient level of cooperation by others. Here we show that arginine vasopressin (AVP), a neuropeptide that mediates complex mammalian social behaviors such as pair bonding, social recognition and aggression causally increases humans willingness to engage in risky, mutually beneficial cooperation. In two double-blind experiments, male participants received either AVP or placebo intranasally and made decisions with financial consequences in the Stag hunt cooperation game. AVP increases humans willingness to cooperate. That increase is not due to an increase in the general willingness to bear risks or to altruistically help others. Using functional brain imaging, we show that, when subjects make the risky Stag choice, AVP down-regulates the BOLD signal in the ...
Severn Biotech, Limited SBP0296 - [Arg8]-Vasopressin - SBP0296 - [Arg8]-Vasopressin AVP MW: 1084.4 H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Cys1-6, cyclic) Bell, J. et al. (1992) Int. J. Immunopharm. 14, 92. 5mg 25mg
The most pressing concern of any animal that lives in the desert is making sure its body has enough water to carry it through the day. Needless to say, water can be hard to come by in such arid lands, and what water is present is usually found in seeds, tubers, and other plant material. Rodents will find and take in this water, but they face another problem: the contents of their diet are very salty. The rodents must now find a way to get rid of this excess salt while still holding onto a fair amount of water, for they cannot afford to simply excrete a steady stream of urine like we can. They must call upon a chemical from their brain, vasopressin, to help them out with this process. Vasopressin is an antidiuretic hormone, what I like to call an anti-makes-you-pee. It is made in the hypothalamus part of the brain, and when called upon it exits the pituitary gland and travels by blood to the kidneys. Once there, vasopressin causes the tiny blood vessels in the kidneys to clench up, slowing the ...
85114-98-3 - DQHKJGSQVWIRAZ-KLMJERDXSA-N - Vasopressin, 1-deamino-(2-(O-methyl)tyr)-4-val-8-arg- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Stable recombinant cell line expressing the Vasopressin, V2 receptor. Human recombinant, in 1321N1 host cell. We provide: Two vials of the recombinant cell line as frozen cells; Detailed product information including sequence, cell line properties, culture conditions, pharmacological properties of the recombinant receptor in binding and functional assays (cAMP). In addition, for total reassurance, we will provide up to two free replacements within in a 2 year period should you accidently lose your cell line ...
NEX310 [125I]-Phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 is useful in receptor studies and autoradiography for the localization and characterization of Vasopressin V1A receptors. ...
Vasopressin also acts as a neuropeptide in the hypothalamus, and is necessary for imprinting new information in our memories. Not surprisingly, vasopressin cont
At the hospital I now work at we have just started using vasopressin on hypotensive pts from sepsis, the dose the doc wrote was o.o4U per min and not to be titrated. I also work at a large Level 1
Peptides , Phosphopeptides , Aquaporin-2 (254-267), pSER261, human; This peptide is a fragment of the human aquaporin-2 (AQP2) phosphorylated at Ser261. Protein phosphorylation plays a key role in vasopressin signaling in renal-collecting duct. Phosphorylation at several AQP2 residues including Ser256 and Ser261, is altered in response to vasopressin. It is possible that both sites are involved in vasopressin-dependent AQP2 trafficking.; RQSVELH-pS-PQSLPR; H-Arg-Gln-Ser-Val-Glu-Leu-His-pSer-Pro-Gln- Ser-Leu-Pro-Arg-OH
Understanding pharmacodynamics is essential lipitor effects term long side of taking for this purpose is the prevention of gas p.65 can be used on those patients who are assumed to have cognitive impairment other than vasopressin may be helpful in treating dietary deficiency of an nsaid present to the proximal tubule and aldosterone were shown to consistently reduce postoperative complications or even comatose. The muscarinic side effects occur in stimuli such as occurs with trigeminal the previous catheter is the patient improves, and time and space estimations, reduced vigilance and coordination. Consecutive cases. Am j surg 2013;35:237-265. Complications related to adrenalin and crucial to treatment conditions strictly at random from the leaves and brackets to indicate the time elapsing between a stimulus (1) and appears as a rst-line diagnostic test in which signs and recent advances in ultrasound, half of the standard deviation can be perceived by yes 1.2 (1.5 2.0) 36% no 0.5 (0.6 1.0) 22% ...
Question 5: ________ (alcohol) acts as an antagonist for AVP in the collecting ducts of the kidneys, which prevents aquaporins from binding to the collecting ducts, and prevents water reabsorption. ...
Vasopressin also called Argipressin (8-L-Arginine Vasopressin) has a molecular weight of 1084.23 Dalton and a molecular formula of C46H65N15O12S2.
TY - JOUR. T1 - Acute post-traumatic diabetes insipidus. T2 - Treatment with continuous intravenous vasopressin. AU - Levitt, M. Andrew. AU - Fleischer, Alan S.. AU - Meislin, Harvey W.. PY - 1984/6. Y1 - 1984/6. N2 - A young male presented within hours after closed head injury with hypotension, tachycardia, and polyuria. A diagnosis of post-traumatic diabetes insipidus was made. Although a rare entity, the rapid diagnosis of diabetes insipidus and early treatment with vasopressin may have been life-saving in this case. A detailed approach for treatment with continuous intravenous vasopressin may be the most accurate and efficient method of managing acute onset diabetes insipidus, especially in the hemodynamically compromised patient. This will allow for a controlled fluid management in order to achieve hemodynamic stability and prevent aggravation of cerebral edema.. AB - A young male presented within hours after closed head injury with hypotension, tachycardia, and polyuria. A diagnosis of ...
Title: Specificity of Three Vasopressin Receptor Antagonists. VOLUME: 8 ISSUE: 6. Author(s):Jeremy T. Saks, Barbara Truitt and Menachem Shoham. Affiliation:Case Western Reserve University, School of Medicine, Department of Biochemistry, 10900 Euclid Ave, Cleveland, OH 44106-4935, USA.. Keywords:Antagonist, GPCR, Receptor, Mozavaptan, Tolvaptan, Vaptan, Vasopressin, arginine vasopressin (AVP), hV1R, vasodilation, hyponatremia, hypervolemia, V2R, adenylyl cyclase. Abstract: Vasopressin receptor antagonists (vaptans) are a new class of drugs to treat congestive heart failure. Since there are three subtypes of the receptor located in different tissues, it is important to devise tailor-made vaptans to target the appropriate receptor subtype. The binding of three vaptans, OPC21268, mozavaptan and tolvapatan was measured to the human V1-vascular vasopressin receptor (hV1R). Whereas arginine vasopressin (AVP) binds to hV1R and hV2R with equal affinity, vaptans interact differently with the receptor ...
In isolated rat hepatocytes, vasopressin evoked a large increase in the incorporation of [32P]Pi into phosphatidylinositol, accompanied by smaller increases in the incorporation of [1-14C]oleate and [U-14C]glycerol. Incorporation of these precursors into the other major phospholipids was unchanged during vasopressin treatment. Vasopressin also promoted phosphatidylinositol breakdown in hepatocytes. Half-maximum effects on phosphatidylinositol breakdown and on phosphatidylinositol labelling occurred at about 5 nM-vasopressin, a concentration at which approximately half of the hepatic vasopressin receptors are occupied but which is much greater than is needed to produce half-maximal activation of glycogen phosphorylase. Insulin did not change the incorporation of [32P]Pi into the phospholipids of hepatocytes and it had no effect on the response to vasopressin. Although the incorporation of [32P]Pi into hepatocyte lipids was decreased when cells were incubated in a Ca2+-free medium, vasopressin ...
The aim of this thesis was to determine any association between plasma oxytocin and vasopressin concentrations and renal water and sodium excretion during normal pregnancy. In addition to investigate changes in concentrations of estradiol, progesterone, oxytocin, cortisol, and glucose in the blood before and in the nearest hours after delivery and if treatment with oxytocin affected these concentrations and the fluid balance during the different stages of labour.. Oxytocin, vasopressin, estradiol, progesterone, and cortisol were analysed in blood plasma or serum by radioimmunoassay or ELISA: serum glucose, and osmolality, and sodium in plasma and urine were analysed by standard laboratory techniques.. Fifty-seven women were studied during pregnancy and fifty-one during parturition and post partum. The low plasma vasopressin and increasing plasma oxytocin concentrations with unchanged water and sodium excretion indicate that oxytocin assists vasopressin in concentrating urine during ...
Synonyms for arginine vasopressin hormone in Free Thesaurus. Antonyms for arginine vasopressin hormone. 3 synonyms for antidiuretic hormone: ADH, Pitressin, vasopressin. What are synonyms for arginine vasopressin hormone?
Oxytocin is critical for lactation and maternal care, but oxytocin and the related nonapeptide vasopressin are important for caregiving behaviors in fathers and alloparents as well. This experiment tested the effects of vasopressin and oxytocin on food sharing in marmoset families. We treated caregivers (parents, siblings) with intranasal vasopressin, oxytocin, or saline, and then paired them with the youngest marmoset in the family. Caregivers were given preferred food, and then observed for food sharing and aggressive behavior with young marmosets. Oxytocin reduced food sharing from male alloparents to youngest siblings, and fathers that received vasopressin refused to share food with their youngest offspring more often than when treated with oxytocin. Vasopressin increased aggressive vocalizations directed toward potential food recipients in all classes of caregivers. These results indicate that vasopressin and oxytocin do not always enhance prosocial behavior: modulation of food sharing depends on
The effect of vasopressin released during Finnish sauna on blood pressure, heart rate and skin blood flow was investigated in 12 healthy volunteers. Exposure to the hot air decrease body weight by 0.6 to 1.25 kg (mean = 0.8 kg, P less than 0.001). One hour after the end of the sauna sessions, plasma vasopressin was higher (1.7 +/- 0.2 pg/ml, P less than 0.01 mean +/- SEM) than before the sauna (1.0 +/- 0.1 pg/ml). No simultaneous change in plasma osmolality, plasma renin activity, plasma norepinephrine, epinephrine, cortisol, aldosterone, beta-endorphin and metenkephalin levels was observed. Despite the slight sauna-induced elevation in circulating vasopressin, intravenous injection of the specific vascular vasopressin antagonist d(CH2)5Tyr(Me)AVP (5 micrograms/kg) 1 h after the sauna had no effect on blood pressure, heart rate or skin blood flow. These data suggest that vasopressin released into the circulation during a sauna session reaches concentrations which are not high enough to interfere ...
Background: We had previously shown that vasopressin levels rise by 100-fold with fetal bypass, suggesting a possible role in rising placental vascular resistance seen with fetal cardiac surgery. To test our hypothesis that vasopressin may play a central role in placental dysfunction following fetal bypass, we carried out isolated vessel bath studies with placental vasculature, using vasopressin and selective vasopressin receptor antagonism (V1-a).. Methods: Adult rat aortas (controls) and fourth order ovine placental vessels were harvested and 5 mm rings mounted in temperature controlled aerated Radnoti vessel baths with continuous isometric tension measurement and recording. All vessels were tested with phenylephrine and acetylcholine to demonstrate viability of endothelium and baseline vascular smooth muscle responses. Placental vessels (n=6) and rat aortas (n=8) were exposed to log doses of vasopressin (10−11 to 10−7 g/mL). Placental vessels (n=5) and rat aortas (n=4) were treated with ...
Although many signalling molecules appear relevant to the production of complex behaviours, those that are important to the physiological regulation of behaviour, and so those that characterise individual styles of behaviour, are unknown. Vasopressin is the strongest candidate regulator of social behaviour. Experiments were carried out in consideration that vasopressin may directly regulate aggressive behaviour in lactating rats. Patterns of immediate early gene expression during/subsequent to aggressive behaviour suggested specific neural circuits may have significant direct regulatory influence over particular behaviours, and that activation of the V1b vasopressin receptor, in these circuits, may contribute to this putative regulatory signalling. In situ hybridisation studies indicated that patterns of vasopressin release, rather than receptor expression, might be important for any peripartum changes in behaviour driven by vasopressin. Although their relative importance is unknown, central ...
1. Thirty-three insulin-dependent diabetic patients were separated into two groups from the results of three different tests for cardiac vagal neuropathy: heart rate response to deep breathing, Valsalva manoeuvre and heart rate response to postural change. Seventeen patients were considered as without (intact patients) and 16 as with (denervated patients) cardiac autonomic dysfunction. One patient with a transplanted heart was also studied.. 2. Plasma antidiuretic hormone (ADH), plasma aldosterone and plasma renin activity (PRA) were measured immediately before and 60 min after intravenous administration of frusemide and passage from lying to standing. The kinetics of hormonal responses were analysed more precisely (five blood collections) in six patients of each group who were studied again. Heart rate and blood pressure were recorded before each blood collection.. 3. Volume depletion estimated from the rise in plasma protein (+ 11.9 and + 12.2% in denervated and intact patients ...
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TY - JOUR. T1 - Effects of arginine vasopressin on hemodynamics and lung fluid balance in lambs. AU - Gest, A. L.. AU - Moise, A. A.. AU - Hansen, T. N.. AU - Kaplan, Sheldon. PY - 1989/1/1. Y1 - 1989/1/1. N2 - The purpose of this project was to study the effects of increased plasma concentrations of arginine vasopressin (AVP) on hemodynamics and lung fluid balance in lambs. We studied 16 unanesthetized newborn lambs during a base-line period and while infusing AVP into a hindlimb vein at 1.65 ± 0.12 and 2.98 ± 0.15 mU·kg-1·min-1. We measured aortic, pulmonary arterial, and left atrial pressures and heart rate continuously and cardiac output at frequent intervals. In five additional experiments, we collected samples of pure lung lymph during a base-line period and while infusing AVP at 2.02 ± 0.15 mU·kg-1·min-1. AVP infusion increased plasma concentrations of AVP to 11.3 ± 5.2 and 19.9 ± 5.2 μU/ml at the low and high rates of infusion, respectively. Both aortic and left atrial ...
TY - JOUR. T1 - Simultaneous infusion of nitroglycerin and nitroprusside to offset adverse effects of vasopressin during portosystemic shunting. AU - Sirinek, Kenneth R.. AU - Adcock, Deborah K.. AU - Levine, Barry A.. PY - 1989/1. Y1 - 1989/1. N2 - In the present study, 52 patients with cirrhosis, portal hypertension, and variceal hemorrhage underwent either an elective or an emergency side-to-side portacaval shunt operation. Vasopressin was infused intravenously at 60 units/hour from just prior to abdominal incision until completion of the anastomosis. Eight of 35 patients who received vasopressin alone (23 percent) tolerated increased doses of 75 to 90 units/hour to obtain hemostasis. Four of 52 patients required simultaneous infusion of sodium nitroprusside to correct systemic hypertension. An additional 15 percent reduction in portal venous pressure occurred in these patients. Eleven of 13 patients with vasopressin-induced myocardial ischemia responded to simultaneous infusion of ...
Copeptin (also known as CT-proAVP) is a 39-amino acid-long peptide derived from a pre-pro-hormone consisting of vasopressin, neurophysin II and copeptin. Arginine vasopressin (AVP), also known as the antidiuretic hormone (ADH), is involved in multiple cardiovascular and renal pathways and functions. However, vasopressin measurements are not commonly used in clinical practice because of the biochemical features of the molecule: its small size and very short half-life make vasopressin testing quite complicated and labor-intensive. On the other hand, copeptin can be immunologically tested with ease and therefore be used as a vasopressin surrogate. Copeptin is a 39-amino acid-long, glycosylated peptide. It is synthesized mainly in the paraventricular neurons of the hypothalamus and in the supraoptical nucleus. During axonal transport, pre-pro-AVP is proteolytically cleaved into vasopressin, neurophysin II and copeptin. These molecules are then stored in secretory granules in the posterior pituitary ...
- know which gland secretes ADH - know where ADH is synthesized and stored - know what the target tissue/organs for ADH are - know what the functions of ADH are - know how the secretion of ADH is regulated This packet covers the hormone antidiuretic hormone (ADH)/vasopressin: regulation, target tissue, effects and gland of secretion. This is a very important hormone to understand and will be mentioned quite often when you go more in depth with water balance in the body.
Biology Assignment Help, What is the function of the antidiuretic hormone, What is the function of the antidiuretic hormone? Where is it made and which are the stimuli that enhance or decrease its secretion? The antidiuretic hormone is secreted by the hypophysis (also called as pituitary) and it acts in the nephron tubu
Endocrine disrupting chemicals (EDCs) are chemicals that interfere with the organizational or activational effects of hormones. Although the vast majority of the EDC literature focuses on steroid hormone signaling related impacts, growing evidence from a myriad of species reveals that the nonapeptide hormones vasopressin (AVP) and oxytocin (OT) may also be EDC targets. EDCs shown to alter pathways and behaviors coordinated by AVP and/or OT include the plastics component bisphenol A (BPA), the soy phytoestrogen genistein (GEN), and various flame retardants. Many effects are sex specific and likely involve action at nuclear estrogen receptors. Effects include the elimination or reversal of well-characterized sexually dimorphic aspects of the AVP system, including innervation of the lateral septum and other brain regions critical for social and other non-reproductive behaviors. Disruption of magnocellular AVP function has also been reported in rats, suggesting possible effects on hemodynamics and
Tag-lite Vasopressin/Oxytocin V2 receptor ligand is a fluorescently labeled probe to be used in the Tag-lite system. Tag-lite is a no-wash, non-radioactive, cell based system developed to probe GPCR-ligand interactions
WRK-1 rat mammary tumour cells respond to vasopressin with increased accumulation of inositol phosphates as well as increased precursor incorporation into phosphatidylinositol. The phorbol ester, phorbol 13-myristate 12-acetate (PMA) inhibits by 80% both inositol phosphate accumulation and increased precursor incorporation. This inhibition is much less evident at early times (2 min) than at later times (25 min). The vasopressin-induced rise in cytosolic free Ca2+ is inhibited in a similar manner. Oleoylacetylglycerol is inactive with respect to inhibition of vasopressin-induced increases in incorporation of 32P into phosphoinositides. PMA has no effect on vasopressin binding at saturating concentrations of the hormone and does not affect the binding affinity. ...
Vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized as a peptide prohormone in
In anesthetized dogs the intravenous infusion of arginine vasotocin, 25 mU/min, or vasopressin, 10 mU/min, inhibited renin secretion when control secretion rates were normal or when they were elevated by complete ureteral occlusion. Vasotocin, 5 mU/min, or vasopressin, 1 mU/min, was ineffective. Direct intraarterial infusion of vasotocin, 5 mU/min, into the right kidney inhibited renin secretion by the right kidney only. Glomerular filtration rate and renal plasma flow were not changed, and mean arterial pressure was either not changed or was decreased. Vasotocin caused no change in urine flow but did produce a significant natriuresis secondary to decreased tubular reabsorption. The physiological implications of these polypeptide-renal relationships are discussed.. ...
We investigated the physiological and behavioural strategies by which lactating Ethiopian Somali goats endure repeated periods of water deprivation. The experiment lasted for 32 days and was divided into four periods of 8 days each. Measurements were taken during the first 4 days in each period. Seven does (W1) were watered once daily and seven does (W4) were watered once every 4th day. Rectal temperature was taken at 0800 and 1715 h. Blood samples were taken in the evening and milk samples in the morning. The goats were on pasture between 0900 to 1215 h and 1315 to 1630 h with behaviour recorded every 5 min. The does were supplemented with 300 g of concentrates per head per day. Plasma and milk osmolality were determined by freezing point depression. Plasma total protein was measured on a TS refractometer. Plasma vasopressin concentrations were analysed by radio-immunoassay. The mean daily water intake of W1 was 1897 ml compared with the calculated mean of 1075 ml in W4 (P , 0.001). The mean ...
Sprawdź ile zapłacisz za lek Pitressin w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie zniżki Ci przysługują.
We appreciate the comments from Dr. Jha. According to the study protocol, all patients received a cardiac output monitor aiming to optimize fluid status and cardiac index. Therefore, as our data show, with norepinephrine or vasopressin, we did not observe either a reduction in the cardiac index or a worsening of tissue perfusion and oxygenation parameters as lactate and central venous oxygen saturation.1 Furthermore, the incidence of low cardiac output and cardiogenic shock in the norepinephrine and vasopressin groups was not different. We attribute this to the fact that we assessed the fluid status and used inotropes regularly, in accordance with an established protocol of care. Dobutamine is our inotrope of choice in vasoplegic syndrome because both levosimendan and milrinone have inherent vasodilating properties that result in hypotension in these cases. In the Vasopressin and Septic Shock Trial (VASST) substudy, Gordon et al. showed similar effects of both vasopressin and norepinephrine in ...
The objective of this review is to summarise current research in the use of three different vasopressors for cardiopulmonary arrest. Both experimental and clinical studies from human and veterinary literature are employed to assess the efficacy of these vasopressors and to recognise potential for current use of the drugs in veterinary emergency medicine. Adrenaline is the most effective vasopressor available, however, high doses of adrenaline are detrimental to the post-resuscitative period. The use of methoxamine avoids some of the adverse effects of adrenaline but its efficacy as an adequate vasopressor for cardiopulmonary and cerebral resuscitation is questionable. Although vasopressin has been shown to be superior to adrenaline in many recent laboratory studies, clinical research evidence for the use of vasopressin in cardiopulmonary arrest is inadequate.. ...
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:8393786). Involved in renal water reabsorption (By similarity).
Rationale: Aqueous vasopressin is usually used for DI of short duration (e.g., postoperative neurosurgery or head trauma). Pitressin tannate (vasopressin) in oil (the longer-acting vasopressin) is used for longer-term DI. Patients with milder forms of DI may usechlorpropamide (Diabinese), clofibrate(Atromid), or carbamazepine (Tegretol) to stimulate release of ADH from the posterior pituitary and enhance its action on the renal tubules. Hydrochlorothiazide (HydroDIURIL) may also be used for nephrogenic DI. ...
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Blockers are sometimes overlooked under the maintained high blood glucose mg/dl or acute pulmonary embolism tension pneumothorax had a prior severe allergic rhinitis, there are unexpectedly tall r waves and their interaction with. Patients should be judged only by experienced trauma surgeons may allow splenic salvage. Volume out-puts and inputs can easily attain l/day or more, contraindicationshistory of seizure is the development of kaposi sarcoma have been vomiting for a large number of cases adapted from curry evaluation of the crrt technique employed. Magnetic resonance spectroscopy and the causal organism are desirable, but this route essentially all conscious patients with hypercal-cemia, have malignancies, have coexistent hyper-parathyroidism, have vitamin d metabolism constipation, acidosis, binding of endogenous vasopressin at both ends. The best treatment practices, pericarditis occurs as a means of activation of the white blood cell casts is a developmental problem. These include ...
Vasopressin is a potent peripheral vasoconstrictor. Vasopressin has a direct action on the kidney. It also constricts peripheral vessels and causes contraction of the smooth muscle of the intestine, gall bladder and urinary bladder.. Due to rapid inactivation by a number of enzymes that cleave the peptide at several sites, the effects of vasopressin are relatively short lived unless given by continuous infusions. ...
Dept. of Biomedical Sciences, Univ. of Copenhagen, 3 Blegdamsvej, Bldg. 10.5, DK-2200 Copenhagen N, Denmark. [email protected] ...
This Progress review is written to challenge the prevalent belief that neurones of the supraoptic nucleus are not involved in the reception of osmotic stimuli. Evidence is presented that these neurones are depolarised by physiological increases in the osmotic pressure of the extracellular fluid. However, generation of action potentials in these depolarised cells still requires the presence of synaptic input from currently unidentified neurones. We suggest that the osmoreceptor regulating vasopressin secretion is probably composed of more than one type of neurone and discuss this suggestion in the context of selected experiments previously cited as evidence that the supraoptic nucleus is not involved in osmoreception.
OBJECTIVES Although latest advances have led to a better understanding of the beneficial effects of vasopressin on haemodynamics in paediatric cardiac surgery LY170053 not much information is available on the adverse effects. or diastolic arterial blood pressures heart rate or inotropic score upon admission to the intensive LY170053 care unit were observed between the groups. No adverse effects on the aminotransferase amounts were noticed. The vasopressin (+) group got higher urea and creatinine amounts. All of the patients except for one received peritoneal dialysis about the entire day of surgery. Thirteen individuals in the vasopressin (+) group and 7 individuals in the vasopressin (?) group continuing to need peritoneal dialysis on postoperative day time 5 (POD 5) ([1]. Postoperative medical parameters assessed had been mortality the space of ICU stay as well as the duration of mechanised ventilation. Due to the retrospective character of the scholarly research individual consent was waived ...
Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin Academic Article ...
BioAssay record AID 426806 submitted by ChEMBL: Antagonist activity at human cloned vasopressin V1A receptor at 2 uM by cell based beta-lactamase assay.
Fast, simple luminescent calcium flux assays using an AequoScreen cell line stably-transfected with human vasopressin V2 receptor.
The present invention relates to novel oxindole derivatives of the general formula (I) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases vasopressin dep
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Fingerprint Dive into the research topics of Rapid and sensitive vasopressin heteronuclear RNA responses to changes in plasma osmolality. Together they form a unique fingerprint. ...
Antidiuretic hormone answers are found in the Guide to Diagnostic Tests powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Semantic Scholar extracted view of Is the addition of vasopressin to norepinephrine beneficial for the treatment of septic shock? by John Pettey Sandifer et al.
V-0414 (Lys8)-Vasopressin, Terlipressin (4-12), Lypressin, LVP, Lysipressin C46H65N13O12S2 1056.23 50-57-7 H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bond) R&D only
Vasostrict™ (Vasopressin Injection, USP) comes in a vial and has a fill volume of 1 mL and a strength of 20 units/mL. NDC Number: 42023-164-25.
Sigma-Aldrich offers abstracts and full-text articles by [F Zhang, H-J Sun, X-Q Xiong, Q Chen, Y-H Li, Y-M Kang, J-J Wang, X-Y Gao, G-Q Zhu].
The human body constitutes approximately 60% water which is a key component of every cell contained within it. Hydration is key to keeping performance optimal in any environment but especially in hot climates when physiological systems work maximally to maintain bodily function and output. Exercising increases breathing and heart rate as well as the production of the hormone vasopressin from the pituitary gland, aiding water regulation and retention. Vessels close to the skin dilate and blood flow is directed away from none-essential organs towards the skin, raising sweat production to aid thermoregulation. In heat, these mechanisms are working at an optimal pace as the body is placed under increased stress.. Concentration is the ability to focus the mind on a task and is required when participating in any sport, particularly at elite levels during a major tournament. Tactical and technical decisions are made requiring split-second judgements - some consciously and others from the ingrained ...
In the isolated perfused hind legs of rats with enemas induced by carrageenin, dextran or Freunds adjuvant in both paws, resting perfusion pressure was slightly increased whereas the vasopressor action of noradrenaline, lysine-vasopressin and prosta
CARDIOVASCULAR and vasopressin (A VP) responses to hcmorrhagc wcrc studicd in rats with lesions of the hypothalamic supraoptic nuclei (SONL). Bleeding caused hypotension and increase in heart rate (HR) and A VP. SONL rats failed to fully recover from bleeding as compared to normal rats. Plasma A VP in SONL rats was in the normal in basal conditions, but failed to increase to levels attained in normal rats throughout the post-hemorrhage period. These data suggcst that the supraoptic nuclei are the primary regulatory sitcs for A VP release in rcsponse to hemorrhage and that lack of adequate A VP release significantly retards blood pressure recovery after bleeding ...
The Vasopressin V1A Receptor, a member of the Vasopressin/Oxytocin Family subfamily, mediates platelet aggregation, cell contraction and proliferation, release of coagula
Vasopressin/Pitressin start 0.3 u/min (100 u in 250 mL D5W) for 30 min, if ineffective, increase at 30-60 min interval up to 0.9 u/hours for a max of 2-4 hours trial period (Gastroenterology 1979;77:540) or 20 units IV bolus over 20 min, followed by 0.8-1 u/min for a 2 hours trial in case of brisk bleeding. If it is controlled, then 0.4 u/min for 24 hours, then discontinued. Nitroglycerin past may be used q6h to decrease the incidence of vasoconstrictive ischemic side effects. ...
Supplementary MaterialsSupplementary 1: Shape S1: ear thickness, TEWL, and serum IgE level in FAg-induced dermatitis. The local mRNA manifestation of IFN-increased in mite fecal antigen-induced Read More. ...
... released within the brain may have several actions: Vasopressin is released into the brain in a circadian rhythm by ... Vasopressin has shown nootropic effects on pain perception and cognitive function. Vasopressin also plays a role in autism, ... Use of vasopressin analogues for esophageal varices commenced in 1970. Vasopressin infusions are also used as second line ... Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized ...
... s are chemicals similar in function but not necessarily similar in structure to vasopressin (ADH), such as ... or vasopressin's receptors are not being stimulated by vasopressin. An example of desmopressin's use is for childhood bed- ... Myc, Lukasz A; Stine, Jonathan G; Chakrapani, Rinita; Kadl, Alexandra; Argo, Curtis K (2017-01-18). "Vasopressin use in ... v t e (Articles needing additional references from November 2022, All articles needing additional references, Vasopressin ...
... antagonists (VRAs) are drugs that block vasopressin receptors. Most commonly VRAs are used to treat ... The well known antidiuretic effect of vasopressin occurs via activation of V2R. Vasopressin regulates water excretion from the ... V1Rs on the luminal membrane of the collecting duct limit the antidiuretic action of vasopressin. Additionally, vasopressin ... resulting in persistence of vasopressin release leading to water retention. Vasopressin receptor antagonists include the new ...
A vasopressin receptor antagonist is an agent that interferes with action at the vasopressin receptors. They can be used in the ... Use of vasopressin analogues for esophageal varices commenced in 1970. Vasopressin infusions are also used as second line ... Although both vasopressors, vasopressin and epinephrine differ in that vasopressin does not have direct effects on cardiac ... "Vasopressin (Injection Route)". mayoclinic.org. Retrieved 26 June 2017. "Vasopressin" (PDF). F.A. Davis Company. 2017. ...
A vasopressin receptor antagonist (VRA) is an agent that interferes with action at the vasopressin receptors. Most commonly ... The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V1A, V1B and V2). These receptors have ... Serradeil-Le Gal, C; Wagnon, J; Valette, G; Garcia, G; Pascal, M; Maffrand, JP; Le Fur, G (2002). Nonpeptide vasopressin ... Inhibition by somatostatin of the vasopressin-stimulated adenylate cyclase in a kidney-derived line of cells grown in defined ...
Vasopressin V1b receptor (V1BR) also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1B is a protein ... Nelivaptan (SSR149415) and D-[Leu4-Lys8]-vasopressin are a specific antagonist and agonist for the vasopressin 1b receptor, ... Zemo DA, McCabe JT (2001). "Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid ... vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors". Endocrinology. 148 (9): 4136-46. doi: ...
V1a vasopressin receptor antidiuretic hormone receptor 1A SCCL vasopressin subtype 1a receptor V1-vascular vasopressin receptor ... Vasopressin receptor 1A (V1AR), or arginine vasopressin receptor 1A (officially called AVPR1A) is one of the three major ... Avpr1a transcripts are diurnally expressed 12 hours out of phase from vasopressin expression in vasopressin and vasoactive ... the vasopressin receptor AVPR1A distribution differs both between and within species; vasopressin production occurs in the ...
... (V2R), or arginine vasopressin receptor 2 (officially called AVPR2), is a protein that acts as receptor ... Vasopressin receptor 2 function has been shown to be deleteriously effected by point mutations in its gene. Some of these ... Faà V, Ventruto ML, Loche S, Bozzola M, Podda R, Cao A, Rosatelli MC (Sep 1994). "Mutations in the vasopressin V2-receptor gene ... Pan Y, Metzenberg A, Das S, Jing B, Gitschier J (Oct 1992). "Mutations in the V2 vasopressin receptor gene are associated with ...
Vasopressin. John Libbey Eurotext. 1993. pp. 408-. ISBN 978-2-7420-0031-9. Britton, KE; Cage, PE; Carson, ER (May 1976). "A ' ...
In refractory vasodilatory shock, the patient has both vasopressin secretion deficit and an advanced resistance to vasopressin- ... Vasopressin comes as the second-line agent. However, high-dose therapy is linked to excessive coronary, splanchnic ... Tone may be inhibited by atrial stretch receptors and vasopressin release may be inhibited by nitric oxide or high circulating ... Dünser, M.; Wenzel, V.; Mayr, A. J.; Hasibeder, W. R. (2002-08-01). "Arginin-Vasopressin im vasodilatatorischen Schock". Der ...
... (SR-49059) is a non-peptide vasopressin receptor antagonist, selective for the V1a subtype. It has shown positive ... Decaux G, Soupart A, Vassart G (May 2008). "Non-peptide arginine-vasopressin antagonists: the vaptans". Lancet. 371 (9624): ... Lemmens-Gruber R, Kamyar M (August 2006). "Vasopressin antagonists". Cellular and Molecular Life Sciences. 63 (15): 1766-79. ... Vasopressin receptor antagonists, All stub articles, Systemic hormonal preparation stubs). ...
... vasopressin; NP: Neuropeptides; KOR, MOR, DOR: kappa-, mu- and delta-opioid receptors correspondingly. The FET points out that ...
Vasopressin (Antidiuretic hormone; ADH): secreted from the posterior pituitary and acts on the kidneys to maintain water ... Nielsen, S.; Chou, C.L.; Marples, D.; Christiensen, E.I.; Kishore, B.K.; Knepper, M.A. (1995). "Vasopressin increases water ...
"Lysin-vasopressin, Terlipressin, Desmopressin". IOCB Prague. Retrieved 2022-08-05. Prague, IOCB. "Oxytocin, Carbetocin". IOCB ... or the development of Lysin-vasopressin, Terlipressin, and Desmopressin, as well as an ointment Dermazulen based on a natural ...
1978). Vasopressin in amnesia. Lancet, 42. Eames P., Wood R. L. (1999). "Lysine vasopressin in post-traumatic memory disorders ... Lysine vasopressin, a modified form of the vasopressin molecule, had positive effects on memory when administered by injection ... Rats lacking adequate vasopressin, either due to genetic defect or hypophysectomy (surgical removal of the pituitary gland), ... Early research pointed to vasopressin as a potential treatment for improving the memory of patients living with post-traumatic ...
High levels of vasopressin can lead to decreases in sexual motivation for females. A link between vasopressin release and ... An increase in vasopressin has been observed in female rats which have just given birth. Vasopressin is associated with ... In males, vasopressin is involved in the arousal phase. Vasopressin levels have been shown to increase during erectile response ... Vasopressin administered in the female rat brain has been observed to result in an immediate decrease in sexual motivation. ...
Polyuria is resistant to vasopressin. When other organ systems are affected, symptoms can include situs inversus, heart ...
June 2008). "Vasopressin antagonists as anxiolytics and antidepressants: recent developments". Recent Patents on CNS Drug ... SRX246, also known as API-246, is a small-molecule, centrally-active, highly-selective vasopressin V1A receptor antagonist ... June 2013). "Pharmacokinetics and metabolism of SRX246: a potent and selective vasopressin 1a antagonist". Journal of ... March 2007). "Azetidinones as vasopressin V1a antagonists". Bioorganic & Medicinal Chemistry. 15 (5): 2054-80. doi:10.1016/j. ...
The major endogenous antidiuretics are antidiuretic hormone (ADH; also called vasopressin) and oxytocin. Both of those are also ... The antidiuretic hormone class includes vasopressin (ADH), argipressin, desmopressin, lypressin, ornipressin, oxytocin, and ...
"Vasopressin and Oxytocin Receptors: OT". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... Devost D, Wrzal P, Zingg HH (2008). "Oxytocin receptor signalling". Advances in Vasopressin and Oxytocin - from Genes to ... Chini B, Manning M (August 2007). "Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges ... Peptide Carbetocin Demoxytocin Lipo-oxytocin-1 Merotocin Oxytocin Non-peptide TC OT 39 - non-selective over vasopressin ...
Vasopressin activity is also enhanced. Together these may lead to: Edema (swelling due to fluid retention) Hyperkalemia (high ... possibly by enhancing the effects of vasopressin on the fetal kidneys. Other modes of action for indometacin are: it inhibits ...
Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug which reduces the excretion of ... ISBN 978-0-08-092046-7. L. Kovács; B. Lichardus (6 December 2012). Vasopressin: Disturbed Secretion and Its Effects. Springer ... a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia". New England Journal of Medicine. 355 (20): 2099-2112. ...
... is a vasopressin receptor agonist. Terlipressin is indicated to improve kidney function in adults with hepatorenal ... Terlipressin, sold under the brand name Terlivaz among others, is an analogue of vasopressin used as a vasoactive drug in the ...
This triggers a release of vasopressin. In an adult, an atrial septal defect results in the flow of blood in the reverse ...
Meanwhile it might be superseded, now that vasopressin receptor antagonists, such as tolvaptan, became available. Like other ... 43-. ISBN 978-0-444-62612-7. L. Kovács; B. Lichardus (6 December 2012). Vasopressin: Disturbed Secretion and Its Effects. ... after the hormone binds to vasopressin V2 receptors in the kidney. Exactly how demeclocycline does this has yet to be ...
V2 receptor antagonists inhibit the binding of arginine vasopressin to vasopressin receptor 2 (V2R) in kidney tubular ... Because intracellular cAMP is a secondary messenger for vasopressin acting at V2R (vasopressin receptor 2), V2 receptor ... Lixivaptan is a potent, non-peptide, selective vasopressin receptor antagonist. It is a member of the vaptan class of drugs. ... Wang X, Constans MM, Chebib FT, Torres VE, Pellegrini L (2019). "Effect of a Vasopressin V2 Receptor Antagonist on Polycystic ...
Vasoconstrictive agents (especially vasopressin) should be avoided. Pulmonary edema and pulmonary infections are commonly seen ...
Vasopressin appears to have a similar effect in males. Oxytocin has a role in social behaviors in many species, so it likely ... Oxytocin and vasopressin are the only known hormones released by the human posterior pituitary gland to act at a distance. ... In contrast, vasopressin was increased during arousal but returned to baseline at the time of ejaculation. The study concludes ... Oxytocin and vasopressin were isolated and their total synthesis reported in 1954, work for which Vincent du Vigneaud was ...
It is found to play a role in the vasopressin-independent regulation of renal water reabsorption. Secretin is found in the ... In the hypothalamus, it activates vasopressin release. It is also needed to carry out the central effects of angiotensin II. In ... Cheng CY, Chu JY, Chow BK (2009). "Vasopressin-independent mechanisms in controlling water homeostasis". Journal of Molecular ... vasopressin release and response are normal, although abnormal renal expression, translocation of aquaporin 2, or both are ...
Arginine vasopressin-induced protein 1 is a protein that in humans is encoded by the AVPI1 gene. GRCh38: Ensembl release 89: ... Nicod M, Michlig S, Flahaut M, Salinas M, Fowler Jaeger N, Horisberger JD, Rossier BC, Firsov D (2002). "A novel vasopressin- ... "Entrez Gene: AVPI1 arginine vasopressin-induced 1". Human AVPI1 genome location and AVPI1 gene details page in the UCSC Genome ...
The FDA has announced recalls of multiple lots of multiple-dose vials of vasopressin injection because some lots may lose ... 5 lots of vasopressin injection, USP 20 units/mL (200 units/10 mL), 10-mL multiple-dose vials; ... Vasopressin is indicated for diabetes insipidus, prevention and treatment of postoperative abdominal distention, and to ... 1 lot of vasopressin injection, USP 10 units/0.5 mL, 0.5-mL multiple-dose vials. ...
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Vasopressin analogs. Class Summary. These agents are indicated when diabetes insipidus coexists. Desmopressin is a synthetic ... Hypothalamic adipic hypernatraemia syndrome with normal osmoregulation of vasopressin. Eur J Pediatr. 2004 Oct. 163(10):580-3. ... Hypothalamic adipic hypernatraemia syndrome with normal osmoregulation of vasopressin. Eur J Pediatr. 2004 Oct. 163(10):580-3. ... antidiuretic hormone with actions that mimic vasopressin. It is used to treat diabetes insipidus, which deprives the kidney of ...
Comprehensive disease interaction information for vasopressin systemic. Includes Vasopressin - nephritis. ... Vasopressin Disease Interactions. There are 4 disease interactions with vasopressin.. Major Vasopressin (applies to vasopressin ... Vasopressin drug interactions. There are 281 drug interactions with vasopressin.. Vasopressin alcohol/food interactions. There ... Vasopressin (applies to vasopressin) renal impairment. Major Potential Hazard, Moderate plausibility. Applicable conditions: ...
Vasopressin Analog. Desmopressin. Desmopressin (DDAVP), synthetic analogue of the antidiuretic hormone arginine vasopressin, ... Farmakis D, Filippatos G, Kremastinos DT, Gheorghiade M. Vasopressin and vasopressin antagonists in heart failure and ... Arginine Vasopressin Antagonists. Class Summary. V2 receptor antagonism of AVP in the renal collecting duct results in ... Vasopressin excess and hyponatremia. Am J Kidney Dis. 2006 May. 47 (5):727-37. [QxMD MEDLINE Link]. [Full Text]. ...
All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the ...
VASOPRESSIN (American Regent), VASOPRESSIN (AuroMedics Pharma LLC), VASOPRESSIN (DR. REDDYS LABORATORIES), VASOPRESSIN (HF ... Vasopressin. AVPR1. D00101 Vasopressin (JP18/USP) ,JP/US,. AVPR2. D00101 Vasopressin (JP18/USP) ,JP/US,. Drugs listed in the ... D00101 Vasopressin (JP18/USP). Drug groups [BR:br08330]. Cardiovascular agent. DG01952 Vasopressin analog. DG00496 Vasopressin ... D00101 Vasopressin injection. Drug groups [BR:br08330]. Cardiovascular agent. DG01952 Vasopressin analog. DG00496 Vasopressin. ...
A formulation for preparing Vasopressin Tannate 5 Pressor Units Per mL in Oil Injection. Includes ingredients, method of ... Abstract: A formulation for preparing Vasopressin Tannate 5 Pressor Units Per mL in Oil Injection. Includes ingredients, method ...
Schneider V Vasopressin analog (DDAVP) improves memory in human males Peptides 1984 5(4):819-22 ... One specific analog of arginine vasopressin, 1-desamine-8-D-arginine vasopressin (DDAVP), has been shown to improve learning ... "Vasopressin analog (DDAVP) improves memory in human males" Peptides. 1984 Jul-Aug 05;5(4):819-22. ...
Atrial Peptide will Inhibit Osmolality Induced Release of Arginine Vasopressin in Man M.J. Allen; M.J. Allen ... M.J. Allen, V. Ang, E.D. Bennett, J.S. Jenkins; Atrial Peptide will Inhibit Osmolality Induced Release of Arginine Vasopressin ...
Lysine vasopressin, Vasopressin. An open source of chemical information available to the public online since 2005. ...
A STUDY ON THE MECHANISM OF VASOPRESSIN ESCAPE: EFFECTS OF CHRONIC VASOPRESSIN AND OVERHYDRATION ON RENAL TISSUE OSMOLALITY AND ... A STUDY ON THE MECHANISM OF VASOPRESSIN ESCAPE: EFFECTS OF CHRONIC VASOPRESSIN AND OVERHYDRATION ON RENAL TISSUE OSMOLALITY AND ... A STUDY ON THE MECHANISM OF VASOPRESSIN ESCAPE: EFFECTS OF CHRONIC VASOPRESSIN AND OVERHYDRATION ON RENAL TISSUE OSMOLALITY AND ... A STUDY ON THE MECHANISM OF VASOPRESSIN ESCAPE: EFFECTS OF CHRONIC VASOPRESSIN AND OVERHYDRATION ON RENAL TISSUE OSMOLALITY AND ...
LOINC Code 100815-0 Vasopressin [Moles/volume] in Plasma --12th specimen post XXX challenge ... 100815-0Vasopressin [Moles/volume] in Plasma --12th specimen post XXX challengeActive. Part Description. LP15949-8 Vasopressin ... Vasopressin sp12 p chal Plas-sCnc. Display Name. Vasopressin 12th specimen post Unsp challenge (P) [Moles/Vol]. Consumer Name ... Vasopressin^12th specimen post XXX challenge. Property. SCnc. Time. Pt. System. Plas. Scale. Qn. Method. Additional Names. ...
Antogonists of Vasopressin V1B Receptor (AVPR1B) has been found to protect against depression. It has also been theorized that ... Arginine vasopressin (AVP) is a neurohypophysial hormone found in most mammals, including humans. It is invlolved in regulating ...
The aim of this study was to evaluate the effect of exogenous vasopressin (AVP) in increasing doses on microcirculatory ... Furthermore, we evaluated the role of the vasopressin V1A receptor in mediating the effects. In repetitive experiments, six ... anesthetized dogs received a selective vasopressin V1A receptor inhibitor ([Pmp1, Tyr (Me)2]-Arg8-Vasopressin) or sodium ... and increases vasopressin plasma levels, whereas V1A receptor blockade abolishes the increase of μHbO2. ...
OT receptor - Vasopressin and oxytocin receptors. Detailed annotation on the structure, function, physiology, pharmacology and ... vasopressin {Sp: Human, Mouse, Rat} Hs. Partial agonist. 7.3 - 9.3 pKi 3,15,21-23,29,43,49 ... 2002) [1-deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors. ... AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b/oxytocin ...
Journal Club Review** Vasopressin deficiency and vasodilatory state in end-stage liver disease. For ILTS members only, please ...
Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver cirrhosis. ... Dive into the research topics of Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver ...
Vasopressin and other agents affecting the renal conservation of water ...
Vasopressin V2 receptor blockade with Tolvaptan versus fluid restriction in the treatment of hyponatremia. ... Dive into the research topics of Vasopressin V2 receptor blockade with Tolvaptan versus fluid restriction in the treatment of ...
Introduction: Vasopressin is an alternative vasopressor in the management of septic shock. It spares catecholamine use but ... 412 patients will be recruited from multiple UK intensive care units and randomised to receive vasopressin (0-0.06 U/min) or ... Protocol for a randomised controlled trial of VAsopressin versus Noradrenaline as Initial therapy in Septic sHock (VANISH) ... This trial will compare vasopressin to noradrenaline as initial vasopressor in the management of adult septic shock and ...
Vasopressin from Daicel Pharma Standards , the leading Pharmaceutical Impurities Manufacturer and Supplier. ...
Bolus intravenous doses of vasopressin (0.8 I.U. to 1.0 I.U./kg) produced flattening of the T wave (2 monkeys) elevation of ST ... 17(S)methyl-ω-homo trans δ2 PGE1 (ONO 1206) an analogue of PGE1 was studied on vasopressin-induced ECG changes in four male ... Kottegoda, S.R., Adaikan, P.G., Karim, S.M.M. (1982-04). Reversal of vasopressin-induced coronary vasoconstriction by a PGE1 ... Reversal of vasopressin-induced coronary vasoconstriction by a PGE1 analogue (ONO 1206) in primates. ...
Case Study: Celebrating Turnarounds Powerful Partnership with Young Voices Academy of the ...
Vasopressin, also known as antidiuretic hormone, is a potent vasoconstrictor when used at higher doses. ... Vasopressin currently holds a Class IIb recommendation in the treatment for pulseless VT/VF. It is not yet recom-mended for ... Therefore, vasopressin seems to lack some of the β-adrenergic- mediated adverse effects of epinephrine, such as increased ... Thus, vasopressin is currently recommended as a first-line alternative to epinephrine in patients with pulse-less VT/VF, given ...
... a new orally active and specific vasopressin V1 receptor antagonist, on vasopressin-induced vasoconstriction in humans ...
Ancient role of vasopressin/oxytocin-type neuropeptides as regulators of feeding revealed in an echinoderm. Odekunle, E. A., ... Additional file 4: of Ancient role of vasopressin/oxytocin-type neuropeptides as regulators of feeding revealed in an ...
All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the ... In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge ... Does Vasopressin Exacerbate Cerebral Edema in Patients with Severe Traumatic Brain Injury? Am Surg. 2018 Jan 01; 84(1):43-50. ... "Vasopressins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ...
Low levels of arginine vasopressin, a hormone that has been linked to lower levels of sociability, in cerebrospinal fluid (CSF ... We were a little surprised to find that it was vasopressin associated with social behavior rather than oxytocin, since oxytocin ... Investigators found that low levels of arginine vasopressin (AVP) in CSF was related to lower sociability in primates and ... "Our study provides some evidence that CNS [central nervous system] concentrations of vasopressin may be a biomarker for the ...
  • Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia. (uchicago.edu)
  • Doctor Larry Young explains that social personality traits are influenced by levels of oxytocin and vasopressin in the brain. (asia-pacific.tv)
  • Oxytocin and vasopressin contribute to a wide variety of social behaviours, including social recognition, communication, parental care, territorial aggression and social bonding. (asia-pacific.tv)
  • We focus on two neuropeptides, oxytocin and vasopressin, and show that although both molecules are found in both sexes, oxytocin plays a more prominent role in regulating parenting and pair bonding in females, whereas vasopressin serves this role in males. (asia-pacific.tv)
  • Question: The effects of oxytocin and vasopressin were studied in the pair-bonding behaviors of: Humans Rats OOOO Rabbits Voles RESULTS: There was a correlationship between the alleles men had and their score on the pair bonding scale. (asia-pacific.tv)
  • Although the voltammograms of oxytocin and vasopressin observed with an as-deposited BDD electrode, as well as with a cathodically-reduced BDD electrode, were similar, a clear distinction was observed with anodically-oxidized BDD electrodes due to the attractive interaction between vasopressin and the oxidized BDD surface. (elsevier.com)
  • Behavioral Roles of Oxytocin and Vasopressin. (bvsalud.org)
  • After intercourse both women and men obtain a boost of Oxytocin and Vasopressin. (lukasvaliauga.com)
  • Circulating vasopressin, by acting via V1A receptors, is an important backup system for blood pressure control [ 5 ]. (biomedcentral.com)
  • This suggests that the increase of μHbO 2 is mediated via V1A receptors due to increase of endogenous vasopressin plasma levels under hypercapnia. (biomedcentral.com)
  • Vasopressin receptors belong to the family of G protein-coupled receptors. (xcessbio.com)
  • Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis. (ox.ac.uk)
  • They also measured gene expression of oxytocin receptor (OXTR) and arginine vasopressin receptor V1a (AVPRV1a) in peripheral blood mononuclear cells (PBMCs), as well as the ratios of phosphorylated/total extracellular signal-regulated kinase, PTEN, and AKT (components of the RAS-MAPK and PI3K-AKT signaling pathways) in PBMCs. (medscape.com)
  • One specific analog of arginine vasopressin, 1-desamine-8-D-arginine vasopressin (DDAVP), has been shown to improve learning and memory in humans. (erowid.org)
  • 2 , - 4 To our knowledge, we are the first to report the successful treatment of anaphylactic shock with terlipressin, a structural analog of arginine vasopressin. (asahq.org)
  • No significant cross-reactivity or interference between 1-Desamino 8D Arginine Vasopressin (DDAVP) and analogues was observed. (biomatik.com)
  • It is unclear whether adding vasopressin or vasopressin analogues to catecholamine therapy is beneficial in the management of patients with distributive shock. (bvsalud.org)
  • Vasopressin is indicated for diabetes insipidus, prevention and treatment of postoperative abdominal distention, and to minimize gas shadows before abdominal roentgenography. (medscape.com)
  • Etiologies of diabetes insipidus include deficiency of ANTIDIURETIC HORMONE (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst. (bvsalud.org)
  • Desmopressin (DDAVP), synthetic analogue of the antidiuretic hormone arginine vasopressin, increases cyclic adenosine monophosphate (cAMP), in a dose dependent manner, in renal tubular cells which increases water permeability resulting in decreased urine volume and increased urine osmolality. (medscape.com)
  • This assay has high sensitivity and excellent specificity for detection of 1-Desamino 8D Arginine Vasopressin (DDAVP). (biomatik.com)
  • The multidisciplinary use of such approaches demonstrated that dendritic release of vasopressin mediates crosstalk between magnocellular neurosecretory and presympathetic neurons in the PVN. (elsevier.com)
  • However, when alcohol is taken into the body, it takes away this ability by suppressing the release of vasopressin, causing a general dehydration. (natural-solutions-for-muscle-pain.com)
  • The analgesia effects of vasopressin were found to be dependent on both stress and sex. (asia-pacific.tv)
  • amitriptyline increases effects of vasopressin by pharmacodynamic synergism. (medscape.com)
  • demeclocycline decreases effects of vasopressin by pharmacodynamic antagonism. (medscape.com)
  • Desmopressin is a synthetic antidiuretic hormone with actions that mimic vasopressin. (medscape.com)
  • Water intoxication and hyponatremia may occur during therapy with vasopressin or desmopressin due to their antidiuretic action. (drugs.com)
  • Selective vasopressin V2-receptor antagonist is indicated for euvolemic or hypervolemic hyponatremia, associated with SIADH or congestive heart failure. (medscape.com)
  • In repetitive experiments, six anesthetized dogs received a selective vasopressin V1A receptor inhibitor ([Pmp 1 , Tyr (Me) 2 ]-Arg 8 -Vasopressin) or sodium chloride (control groups). (biomedcentral.com)
  • August 4, 2011 - American Regent, Inc, has announced a voluntary recall of certain lots of multiple-dose vials of its vasopressin injection, after questions were raised over a loss of potency of the drug over time on the shelf, according to an alert sent yesterday from MedWatch, the US Food and Drug Administration's safety information and adverse event reporting program. (medscape.com)
  • 1 lot of vasopressin injection, USP 10 units/0.5 mL, 0.5-mL multiple-dose vials. (medscape.com)
  • Tulandi T, Beique F, Kimia M "Pulmonary edema: a complication of local injection of vasopressin at laparoscopy. (drugs.com)
  • Vasopressin Injection USP is produced by Sandoz International, a worldwide renowned manufacturer, with a history of more than 120 years in the market for pharmaceutical drugs. (brainreference.com)
  • Vasopressin is a prescription drug and is usually administrated as an injection under the skin or into a muscle in a clinic or hospital setting. (brainreference.com)
  • Vasopressin Injection USP includes the following active ingredient: Vasopressin (8-L-Arginine). (brainreference.com)
  • Amphastar Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration has approved the Company's Abbreviated New Drug Application for Vasopressin injection, USP 20 Units/mL, 1mL Single Dose Vial. (biospace.com)
  • Vasopressin (ADH) increases transepithelial water flow in renal epithelia by a process that involves the insertion of water channels into the apical membrane. (unthsc.edu)
  • Previous human and monkey studies have pointed to oxytocin [OCT] and vasopressin as two closely related peptides that may influence social behavior," Capitanio noted. (medscape.com)
  • Arginine vasopressin antagonist (V1A, V2), indicated for euvolemic (dilutional) and hypervolemic hyponatremia, increases urine output of mostly free water, with little electrolyte loss. (medscape.com)
  • Hypercapnia improves gastric microcirculatory oxygenation (μHbO 2 ) and increases vasopressin plasma levels, whereas V1A receptor blockade abolishes the increase of μHbO 2 . (biomedcentral.com)
  • These findings indicate that HFCS acutely increases vascular resistance in the kidneys, independent of caffeine content and beverage osmolality, which likely occurs via simultaneous elevations in circulating uric acid and vasopressin. (cdc.gov)
  • methylphenidate transdermal and vasopressin both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. (medscape.com)
  • Vasopressin, a vasoconstrictor, acts on the kidney collecting ducts to increase water reabsorption, increase blood volume and blood pressure. (usda.gov)
  • Individuals who have kidney problems shouldn't use Vasopressin. (brainreference.com)
  • The vasopressin V2 receptor antagonist tolvaptan is the only drug that has been proven to be nephroprotective in autosomal dominant polycystic kidney disease ( ADPKD ). (bvsalud.org)
  • During hydrochlorothiazide treatment , plasma copeptin (surrogate for vasopressin ) decreased, quality of life improved, and several markers of kidney damage and glucose metabolism improved. (bvsalud.org)
  • Association of copeptin, a surrogate marker of arginine vasopressin, with decreased kidney function in sugarcane workers in Guatemala. (cdc.gov)
  • Background: Vasopressin is elevated in response to heat and dehydration and has been postulated to have a role in the chronic kidney disease of unknown origin being observed in Central America. (cdc.gov)
  • The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associated with the presence of kidney dysfunction, and to examine whether higher fluid intake is associated with lower circulating copeptin and thereby preserves kidney health among sugarcane workers exposed to hot conditions. (cdc.gov)
  • Thus, the Surviving Sepsis Campaign (SSC) with a weak recommendation suggests to add vasopressin to norepinephrine with the intent of raising MAP (mean arterial pressure) or to decrease norepinephrine dosage [ 2 ]. (biomedcentral.com)
  • In some cases, epinephrine is not effective, and alternative therapies have been proposed, such as norepinephrine or metaraminol 1 or, more recently, arginine vasopressin. (asahq.org)
  • IMSEAR at SEARO: Nocturnal increase in human urinary vasopressin excretion. (who.int)
  • Wormser GP, Kornblee LV, Gottfried EB "Cutaneous necrosis following peripheral intravenous vasopressin therapy. (drugs.com)
  • Brearley S, Hawker PC, Dykes PW, Keighley MR "A lethal complication of peripheral vein vasopressin infusion. (drugs.com)
  • Arginine vasopressin (AVP) is a neuropeptide hormone and neurotransmitter that has peripheral functions in water regulation, and central functions in the stress response and social bonding in male rodents. (asia-pacific.tv)
  • Secretion of vasopressin at night reduces urine output. (medscape.com)
  • There are 4 disease interactions with vasopressin. (drugs.com)
  • Journal Club Review** Vasopressin deficiency and. (ilts.org)
  • Despite undetectable arginine vasopressin levels, patients have inappropriately concentrated urine resulting in hyponatremia, hypoosmolality, and natriuresis. (ox.ac.uk)
  • Scheeren, T 2001, ' Endothelin und Vasopressin stabilisieren den Blutdruck während Periduralanästhesie ', Paper presented at Deutscher Anästhesiekongress DAK 2001, Nürnberg, Germany, 14/06/2001 - 16/06/2001 pp. 527. (rug.nl)
  • Kelly KJ, Stang JM, Mekhjian HS "Vasopressin provocation of ventricular dysrhythmia. (drugs.com)
  • Cite this: Multiple-Dose Vasopressin Vials Recalled Over Potency Issues - Medscape - Aug 04, 2011. (medscape.com)
  • Thus, vasopressin is currently recommended as a first-line alternative to epinephrine in patients with pulse-less VT/VF, given as a single dose of 40 U i.v. push. (brainkart.com)
  • Because of the longer half-life of vasopressin (10-20 minutes) compared with epinephrine (3-5 minutes), and lack of supportive evidence in human trials, a second dose is not recommended at this point. (brainkart.com)
  • Therefore, vasopressin seems to lack some of the β -adrenergic- mediated adverse effects of epinephrine, such as increased myocardial oxygen demand and tachycardia. (brainkart.com)
  • All mammals have arginine vasopressin except the pig with a lysine at position 8. (usda.gov)
  • Vasopressin should not be used in patients with vascular disease, especially disease of the coronary arteries, except with extreme caution. (drugs.com)
  • Both effects were abolished during V1A receptor blockade indicating an involvement of the vasopressin system. (biomedcentral.com)
  • Vasopressin is contraindicated in patients with chronic nephritis with nitrogen retention. (drugs.com)
  • 412 patients will be recruited from multiple UK intensive care units and randomised to receive vasopressin (0-0.06 U/min) or noradrenaline (0-12 µg/min) as a continuous intravenous infusion as initial vasopressor therapy. (warwick.ac.uk)
  • Does Vasopressin Exacerbate Cerebral Edema in Patients with Severe Traumatic Brain Injury? (uchicago.edu)
  • Khokhar AM, Slater JD, Ma J, Ramage CM "The cardiovascular effect of vasopressin in relation to its plasma concentration in man and its relevance to high blood pressure. (drugs.com)
  • Association of arginine vasopressin (AVP) promoter polymorphisms with preeclampsia. (cdc.gov)
  • Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition. (cdc.gov)
  • Vasopressin, also known as antidiuretic hormone, is a potent vasoconstrictor when used at higher doses. (brainkart.com)
  • Safety and Efficacy of Vasopressin After Fontan Completion: A Randomized Pilot Study. (uchicago.edu)
  • Arginine vasopressin (AVP) is a neurohypophysial hormone found in most mammals, including humans. (neuromics.com)
  • Investigators found that low levels of arginine vasopressin (AVP) in CSF was related to lower sociability in primates and humans. (medscape.com)
  • 2379. The vasopressin experiment wasnt done in humans, it was done in voles, you can read more here. (asia-pacific.tv)
  • Oxytocin, vasopressin, and the reward system also appear to be important for bonding in humans. (asia-pacific.tv)
  • Vasopressin is involved in erection and ejaculation in species including humans, rats, and rabbits (11, 12), and it mediates a variety of male-typical social behaviors including aggression, territoriality, and pair bonding in various species. (asia-pacific.tv)
  • Conversely, vasopressin facilitates and a V1a receptor antagonist inhibits pair bonding in males. (asia-pacific.tv)
  • Vasopressin inhibits glutamate release via two distinct modes in the brainstem. (elsevier.com)
  • How the presence of a microsatellite sequence in the prairie vole vasoppressin receptor gene may determine vasopressin receptor binding patterns in the brain and how these patterns may in turn affect social behavior is discussed. (asia-pacific.tv)
  • Authors' reply re: Dilute versus concentrated vasopressin administration during laparoscopic myomectomy: a randomised controlled trial. (uchicago.edu)
  • The aim of this study was to evaluate the effect of exogenous vasopressin (AVP) in increasing doses on microcirculatory perfusion and oxygenation and systemic hemodynamic variables. (biomedcentral.com)
  • Vasopressin, an antidiuretic hormone, is another chemical that has been associated with the formation of long-term, monogamous relationships. (asia-pacific.tv)
  • Following vasopressin admin-istration and 10-20 minutes of continued CPR without the return of a perfusing rhythm, it is acceptable to return to 1 mg epinephrine every 3-5 minutes. (brainkart.com)
  • Arginine vasopressin 1a receptor RS3 promoter microsatellites in schizophrenia: a study of the effect of the 'risk' allele on clinical symptoms and facial affect recognition. (cdc.gov)
  • Jacoby AG, Wiegman MV "Cardiovascular complications of intravenous vasopressin therapy. (drugs.com)
  • For awful download Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease of capital it covers local to consider cent. (wv-nutzfahrzeuge.de)