Vasodilator Agents: Drugs used to cause dilation of the blood vessels.Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.Nitroprusside: A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.Vasodilation: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Vascular Resistance: The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.Forearm: Part of the arm in humans and primates extending from the ELBOW to the WRIST.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.Bradykinin: A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.Vasoconstriction: The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.Epoprostenol: A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).Calcitonin Gene-Related Peptide: Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.Vasoconstrictor Agents: Drugs used to cause constriction of the blood vessels.Mesenteric Arteries: Arteries which arise from the abdominal aorta and distribute to most of the intestines.Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Pulmonary Circulation: The circulation of the BLOOD through the LUNGS.Adenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.Coronary Vessels: The veins and arteries of the HEART.Vasomotor System: The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.Splanchnic Circulation: The circulation of blood through the BLOOD VESSELS supplying the abdominal VISCERA.omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Arginine: An essential amino acid that is physiologically active in the L-form.Arterioles: The smallest divisions of the arteries located between the muscular arteries and the capillaries.Endothelium-Dependent Relaxing Factors: Paracrine substances produced by the VASCULAR ENDOTHELIUM with VASCULAR SMOOTH MUSCLE relaxation (VASODILATION) activities. Several factors have been identified, including NITRIC OXIDE and PROSTACYCLIN.Plethysmography: Recording of change in the size of a part as modified by the circulation in it.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Adrenomedullin: A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.Renal Circulation: The circulation of the BLOOD through the vessels of the KIDNEY.Cromakalim: A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.Nitroarginine: An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)Minoxidil: A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)Pulmonary Artery: The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.Isosorbide Dinitrate: A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.Arteries: The vessels carrying blood away from the heart.Biological Factors: Endogenously-synthesized compounds that influence biological processes not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS.Microcirculation: The circulation of the BLOOD through the MICROVASCULAR NETWORK.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Prostaglandins: A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Benzopyrans: Compounds with a core of fused benzo-pyran rings.15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid: A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)
Relaxin is a potent renal vasodilator in conscious rats. (1/7071)The kidneys and other nonreproductive organs vasodilate during early gestation; however, the "pregnancy hormones" responsible for the profound vasodilation of the renal circulation during pregnancy are unknown. We hypothesized that the ovarian hormone relaxin (RLX) contributes. Therefore, we tested whether the administration of RLX elicits renal vasodilation and hyperfiltration in conscious adult, intact female rats. After several days of treatment with either purified porcine RLX or recombinant human RLX 2 (rhRLX), effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) increased by 20%-40%. Comparable renal vasodilation and hyperfiltration was also observed in ovariectomized rats, suggesting that estrogen and progesterone are unnecessary for the renal response to rhRLX. The nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl ester completely abrogated the increase in ERPF and GFR elicited by chronic administration of purified porcine RLX. In contrast, the renal vasoconstrictory response to angiotensin II was attenuated by the RLX treatment. Short-term infusion of purified porcine RLX to conscious rats over several hours failed to increase ERPF and GFR. Plasma osmolality was consistently reduced by the chronic administration of both RLX preparations. In conclusion, the renal and osmoregulatory effects of chronic RLX administration to conscious rats resemble the physiological changes of pregnancy in several respects: (a) marked increases in ERPF and GFR with a mediatory role for nitric oxide; (b) attenuation of the renal circulatory response to angiotensin II; and (c) reduction in plasma osmolality. (+info)
Loss of endothelium and receptor-mediated dilation in pial arterioles of rats fed a short-term high salt diet. (2/7071)A high salt diet often is regarded as an accessory risk factor in hypertension, coincidental to the deleterious effect of high blood pressure on vasodilator function. The aim of this study was to determine whether short-term ingestion of a high salt diet per se impairs vasodilator function in the cerebral circulation independent of blood pressure changes. Adult Sprague-Dawley rats were fed a normal salt (0.8%) or high salt (4%) diet for 3 days. Mean arterial pressures were similar in the normal and high salt groups (123+/-2 and 125+/-2 mm Hg, respectively). Subsequently, the responses of the in situ pial arterioles to acetylcholine, iloprost, and sodium nitroprusside were determined in cranial windows using intravital videomicroscopy. Pial arterioles of rats fed normal and high salt diets showed similar resting diameters of 69+/-2 and 72+/-3 microm, respectively, but their reactivity patterns to vasodilator stimuli were markedly different. Arterioles of rats fed a normal salt diet dilated progressively up to 17+/-3% in response to the endothelium-dependent agent acetylcholine (10(-9) to 10(-6) mol/L) and dilated by 22+/-2% in response to the prostaglandin I2 receptor agonist iloprost (3x10(-11) mol/L). In contrast, pial arterioles of rats fed a high salt diet constricted by 4+/-3% and 8+/-2% in response to acetylcholine and iloprost, respectively. Sodium nitroprusside (10(-6) mol/L), a nitric oxide donor, dilated pial arterioles of rats fed low and high salt diets by a similar amount (19+/-3% and 16+/-2%, respectively), suggesting that signaling mechanisms for dilation distal to the vascular smooth muscle membrane were intact after high salt intake. These results provide the first evidence that the short-term ingestion of a high salt diet may severely impair the vasodilator function of the in situ cerebral microcirculation independent of blood pressure elevation. (+info)
Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. (3/7071)We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates nitric oxide (NO) release in the rat kidney. To further investigate whether the NO-cGMP pathway is involved in the mechanisms of AM-induced vasodilation, we examined the effects of E-4021, a cGMP-specific phosphodiesterase inhibitor, on AM-induced vasorelaxation in aortic rings and perfused kidneys isolated from Wistar rats. We also measured NO release from the kidneys using a chemiluminescence assay. AM (10(-10) to 10(-7) mol/L) relaxed the aorta precontracted with phenylephrine in a dose-dependent manner. Denudation of endothelium (E) attenuated the vasodilatory action of AM (10(-7) mol/L AM: intact (E+) -25.7+/-5.2% versus denuded (E-) -7. 8+/-0.6%, P<0.05). On the other hand, pretreatment with 10(-8) mol/L E-4021 augmented AM-induced vasorelaxation in the intact aorta (-49. 0+/-7.9%, P<0.05) but not in the denuded one. E-4021 also enhanced acetylcholine (ACh)-induced vasorelaxation in the rat intact aorta (10(-7) mol/L ACh -36.6+/-8.4% versus 10(-8) mol/L E-4021+10(-7) mol/L ACh -62.7+/-3.1%, P<0.05). In perfused kidneys, AM-induced vasorelaxation was also augmented by preincubation with E-4021 (10(-9) mol/L AM -15.4+/-0.6% versus 10(-8) mol/L E-4021+10(-9) mol/L AM -23.6+/-1.2%, P<0.01). AM significantly increased NO release from rat kidneys (DeltaNO: +11.3+/-0.8 fmol. min-1. g-1 kidney at 10(-9) mol/L AM), which was not affected by E-4021. E-4021 enhanced ACh-induced vasorelaxation (10(-9) mol/L ACh -9.7+/-1.7% versus 10(-8) mol/L E-4021+10(-9) mol/L ACh -18.8+/-2.9%, P<0.01) but did not affect ACh-induced NO release from the kidneys. In the aorta and the kidney, 10(-4) mol/L of NG-nitro-L-arginine methyl ester, an NO synthase inhibitor, and 10(-5) mol/L of methylene blue, a guanylate cyclase inhibitor, reduced the vasodilatory effect of AM. These results suggest that the NO-cGMP pathway is involved in the mechanism of AM-induced vasorelaxation, at least in the rat aorta and kidney. (+info)
Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation. (4/7071)BACKGROUND: The cardiovascular complications of Marfan syndrome arise due to alterations in the structural and functional properties of fibrillin, a constituent of vascular connective tissues. Fibrillin-containing microfibrils are closely associated with arterial endothelial cells, indicating a possible functional role for fibrillin in the endothelium. Plasma concentrations of endothelial cell products are elevated in Marfan subjects, which indirectly indicates endothelial dysfunction. This study directly assessed flow- and agonist-mediated endothelium-dependent brachial artery reactivity in Marfan subjects. METHODS AND RESULTS: In 20 Marfan and 20 control subjects, brachial artery diameter, blood flow, and blood pressure were measured by ultrasonic wall tracking, Doppler ultrasound, and photoplethysmography, respectively. Measurements were taken during hand hyperemia (a stimulus for endothelium-derived nitric oxide [NO] release in the upstream brachial artery) and after sublingual administration of the endothelium-independent vasodilator nitroglycerin. In 9 Marfan and 6 control subjects, the above parameters were also assessed during intra-arterial infusions of acetylcholine and bradykinin (agonists that stimulate NO production) and NG-monomethyl-L-arginine (L-NMMA, an inhibitor of NO production). Flow-mediated responses differed markedly between Marfan and control subjects (-1.6+/-3.5% versus 6. 50+/-4.1%, respectively; P<0.0001), whereas nitroglycerin produced similar vasodilation (14.2+/-5.7% versus 15.2+/-7.8%; P=NS). Agonist-induced vasodilation to incremental intra-arterial infusions of acetylcholine and bradykinin were not significantly different between Marfan and control subjects, and intra-arterial L-NMMA produced similar reductions in brachial artery diameter in both groups. CONCLUSIONS: These data demonstrate impaired flow-mediated but preserved agonist-mediated endothelium-dependent vasodilation in Marfan subjects and suggest preservation of basal NO release. Selective loss of flow-mediated dilation suggests a role for fibrillin in endothelial cell mechanotransduction. (+info)
Simultaneous assessment of effects of coronary vasodilators on the coronary blood flow and the myocardial contractility by using the blood-perfused canine papillary muscle. (5/7071)Effects of 6 coronary vasodilators on the coronary blood flow and the contractile force of the ventricular muscle were examined simultaneously by injecting these drugs to the arterially blood-perfused canine papillary muscle preparation. All compounds produced a dose-dependent increase in blood flow rate, and relative potencies determined on the basis of doses producing a 100% increase in blood flow rate, ED100, were in the descending order : nifedipine greater than verapamil greater than diltiazem greater than dilazep greater than dipyridamole greater than carbochromen, and approximately 1 : 1/12 : 1/26 : 1/100 : 1/300 : 1/500. All drugs except for dipyridamole caused a dose-dependent decrease in the developed tension of the papillary muscle, although nifedipine and diltiazem in low doses produced a slight increase. Relative potencies determined on the basis of doses producing a 50% decrease in developed tension, ID50, were as follows: nifedipine (1), verapamil (1/13), diltiazem (1/40), dilazep (1/100), and carbochromen (1/270). Ratios of the ID50 to ED100 were as follows: diltiazem (5.2), nifedipine (3.5), verapamil (3.5), dilazep (2.5), and carbochromen (1.8). The higher the value the more predominant on the coronary vascular bed or the less depressant on the myocardial contractility were their actions. (+info)
Inhibition of endothelium-dependent hyperpolarization by endothelial prostanoids in guinea-pig coronary artery. (6/7071)1. In smooth muscle of the circumflex coronary artery of guinea-pig, acetylcholine (ACh, 10(-6) M) produced an endothelium-dependent hyperpolarization consisting of two components. An initial component that occurs in the presence of ACh and a slow component that developed after ACh had been withdrawn. Each component of the hyperpolarization was accompanied by an increase in membrane conductance. 2. Indomethacin (5 x 10(-6) M) or diclofenac (10(-6) M), both inhibitors of cyclooxygenase, abolished only the slow hyperpolarization. The initial hyperpolarization was not inhibited by diclofenac nor by nitroarginine, an inhibitor of nitric oxide synthase. 3. Both components of the ACh-induced hyperpolarization were abolished in the presence of atropine (10(-6) M) or high-K solution ([K+]0 = 29.4 mM). 4. The interval between ACh-stimulation required to generate an initial hyperpolarization of reproducible amplitude was 20 min or greater, but it was reduced to less than 5 min after inhibiting cyclooxygenase activity. Conditioning stimulation of the artery with substance P (10(-7) M) also caused a long duration (about 20 min) inhibition of the ACh-response. 5. The amplitude of the hyperpolarization generated by Y-26763, a K+-channel opener, was reproducible within 10 min after withdrawal of ACh. 6. Exogenously applied prostacyclin (PGI2) hyperpolarized the membrane and reduced membrane resistance in concentrations over 2.8 x 10(-9)M. 7. At concentrations below threshold for hyperpolarization and when no alteration of membrane resistance occurred, PGI2 inhibited the initial component of the ACh-induced hyperpolarization. 8. It is concluded that endothelial prostanoids, possibly PGI2, have an inhibitory action on the release of endothelium-derived hyperpolarizing factor. (+info)
Acetylcholine-induced membrane potential changes in endothelial cells of rabbit aortic valve. (7/7071)1. Using a microelectrode technique, acetylcholine (ACh)-induced membrane potential changes were characterized using various types of inhibitors of K+ and Cl- channels in rabbit aortic valve endothelial cells (RAVEC). 2. ACh produced transient then sustained membrane hyperpolarizations. Withdrawal of ACh evoked a transient depolarization. 3. High K+ blocked and low K+ potentiated the two ACh-induced hyperpolarizations. Charybdotoxin (ChTX) attenuated the ACh-induced transient and sustained hyperpolarizations; apamin inhibited only the sustained hyperpolarization. In the combined presence of ChTX and apamin, ACh produced a depolarization. 4. In Ca2+-free solution or in the presence of Co2+ or Ni2+, ACh produced a transient hyperpolarization followed by a depolarization. In BAPTA-AM-treated cells, ACh produced only a depolarization. 5. A low concentration of A23187 attenuated the ACh-induced transient, but not the sustained, hyperpolarization. In the presence of cyclopiazonic acid, the hyperpolarization induced by ACh was maintained after ACh removal; this maintained hyperpolarization was blocked by Co2+. 6. Both NPPB and hypertonic solution inhibited the membrane depolarization seen after ACh washout. Bumetanide also attenuated this depolarization. 7. It is concluded that in RAVEC, ACh produces a two-component hyperpolarization followed by a depolarization. It is suggested that ACh-induced Ca2+ release from the storage sites causes a transient hyperpolarization due to activation of ChTX-sensitive K+ channels and that ACh-activated Ca2+ influx causes a sustained hyperpolarization by activating both ChTX- and apamin-sensitive K+ channels. Both volume-sensitive Cl- channels and the Na+-K+-Cl- cotransporter probably contribute to the ACh-induced depolarization. (+info)
Enantioselective inhibition of the biotransformation and pharmacological actions of isoidide dinitrate by diphenyleneiodonium sulphate. (8/7071)1. We have shown previously that the D- and L- enantiomers of isoidide dinitrate (D-IIDN and L-IIDN) exhibit a potency difference for relaxation and cyclic GMP accumulation in isolated rat aorta and that this is related to preferential biotransformation of the more potent enantiomer (D-IIDN). The objective of the current study was to examine the effect of the flavoprotein inhibitor, diphenyleneiodonium sulphate (DPI), on the enantioselectivity of IIDN action. 2. In isolated rat aortic strip preparations, exposure to 0.3 microM DPI resulted in a 3.6 fold increase in the EC50 value for D-IIDN-induced relaxation, but had no effect on L-IIDN-induced relaxation. 3. Incubation of aortic strips with 2 microM D- or L-IIDN for 5 min resulted in significantly more D-isoidide mononitrate formed (5.0 +/- 1.5 pmol mg protein(-1)) than L-isoidide mononitrate (2.1 +/- 0.7 pmol mg protein(-1)) and this difference was abolished by pretreatment of tissues with 0.3 microM DPI. DPI had no effect on glutathione S-transferase (GST) activity or GSH-dependent biotransformation of D- or L-IIDN in the 105,000 x g supernatant fraction of rat aorta. 4. Consistent with both the relaxation and biotransformation data, treatment of tissues with 0.3 microM DPI significantly inhibited D-IIDN-induced cyclic GMP accumulation, but had no effect on L-IIDN-induced cyclic GMP accumulation. 5. In the intact animal, 2 mg kg(-1) DPI significantly inhibited the pharmacokinetic and haemodynamic properties of D-IIDN, but had no effect L-IIDN. 6. These data suggest that the basis for the potency difference for relaxation by the two enantiomers is preferential biotransformation of D-IIDN to NO, by an enzyme that is inhibited by DPI. Given that DPI binds to and inhibits NADPH-cytochrome P450 reductase, the data are consistent with a role for the cytochromes P450-NADPH-cytochrome P450 reductase system in this enantioselective biotransformation process. (+info)
... are medications that work directly on the muscles in blood vessel walls to make them dilate. People who suffer from hypertension often take vasodilators in order to allow blood to flow more easily through the arteries. When high blood pressure goes unchecked, it can lead to more serious problems, such as heart attacks, stroke, heart failure, and even kidney failure.. Vasodilators are rarely prescribed alone, which means that they are taken as part of a complete treatment plan. If you have been told you have hypertension and you want to try and stabilize blood pressure through natural supplements, you have some options. You may want to look into GABA supplements and HGH supplements as part of a natural treatment plan to lower your blood pressure.. Gamma Amino Butyric Acid is an amino acid and a neurotransmitter found in the brain that helps to control blood pressure. In addition, GABA can induce relaxation in a person as well as enhance natural sleep cycles. People who take GABA may ...
Age-related differences in the β-adrenergic vasodilator response in rat aortic rings<...
TY - JOUR. T1 - Age-related differences in the β-adrenergic vasodilator response in rat aortic rings. AU - Castillo-Hernandez, Maria Del Carmen. AU - Meraz-Cruz, Noemi. AU - Guevara-Balcazar, Gustavo. AU - Lopez-Canales, Jorge. AU - Lopez-Canales, Oscar. AU - Galindo, Norma. AU - Castillo-Henkel, Carlos. PY - 2010/12/1. Y1 - 2010/12/1. N2 - Mechanisms underlying age-dependent changes in vasodilator responses to β-adrenergic drugs are poorly understood. The aim of the current study was to compare responses to isoproterenol (a non-selective β-adrenergic receptor agonist) in phenylephrine or KCl precontracted aortic rings from 3 week and 3 month old male Wistar rats. Both the mechanism and the subtype of β-adrenergic receptor underlying the response to isoproterenol in the both age groups were examined. Endothelial removal, pre-contraction with KCl (40 mM), pre-treatment with tetraethylammonium or with Nω-Nitro-L-arginine methyl ester inhibited the vasodilator response to isoproterenol only in ...
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1.Inhaled vasodilators such as nitric oxide and epoprostenol (prostaglandin I2) are now widely employed as supportive therapies to improve oxygenation and reduce pulmonary vascular resistance in patients with acute and chronic pulmonary hypertension. However, few data exist concerning their effects in normal individuals. The aim of this study was to characterize the response of the pulmonary circulation in normal individuals to inhaled nitric oxide and nebulized prostaglandin I2.. 2.Eight healthy volunteers were exposed to inhaled nitric oxide (0, 20 and 40 ;p.p.m.) and nebulized prostaglandin I2 (10 ;μg/ml). Changes in effective pulmonary blood flow and diffusing capacity of the lung for carbon monoxide (TLCO) were measured using respiratory mass spectrometry. Bicycle ergometry was used to increase effective pulmonary blood flow as a positive control.. 3.Exercise produced significant increases in both effective pulmonary blood flow and TLCO, but neither nitric oxide nor prostaglandin I2 ...
Global Vasodilators Market Demand,Opportunity,Forecast 2019-2025 - Market Forecast
Vasodilators are medicines that dilate (widen) blood vessels, allowing blood to flow more easily through. Some act directly on the smooth muscle cells lining the blood vessels. Other have a central effect, and regulate blood pressure most likely through the vasomotor center located within the medulla oblongata of the brain.The global Vasodilators market was valued at xx million US$ in 2018 and will reach xx million US$ by the end of 2025, growing at a CAGR of xx% during 2019-2025.. Request for [email protected] https://www.researchtrades.com/discount/1702791. This report focuses on Vasodilators volume and value at global level, regional level and company level. From a global perspective, this report represents overall Vasodilators market size by analyzing historical data and future prospect.Regionally, this report categorizes the production, apparent consumption, export and import of Vasodilators in North America, Europe, China, Japan, Southeast Asia and India.For each manufacturer covered, this ...
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Vasonit (Pentoxifylline) improves microcirculation and blood rheology, has a vasodilatory effect. As the active substance comprises pentoxifylline - xanthine derivative. The mechanism of action is related to inhibition of phosphodiesterase and cAMP accumulation in vascular smooth muscle cells in blood cells in other tissues and organs.
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Nitroglycerin is how nitroglycerin works how to store nitroglycerin nitroglycerin mechanism nitroglycerin drug in a group of drugs called nitrates . types of nitroglycerin how does nitroglycerin work in the body nitroglycerin mg nitroglycerin under It is used to treat or prevent attacks of chest pain (angina) by relaxing the arteries and veins in the body ...
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This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.. © Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.. ...
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This work done by an eminent group in the area raises concerns over the use of regadenoson for clinical stress testing, whether done by PET or SPECT. Invasive and pharmacologic studies had previously demonstrated peak regadenoson effect at approximately 1-2 minutes after injection, consistent with the findings of the present study. Stress labs which are not already following a 1- to 2-minute delay may wish to consider introducing one.. There are several reasons to view these results with caution, however. First, many prior studies had compared regadenoson to other vasodilators using a variety of techniques including PET, SPECT, and invasive methods. In general, no significant differences or only minimal differences, below the level of clinical relevance, were observed. The reasons for the discrepancies are unclear.. One longstanding concern with regards to regadenoson has been the use of a single fixed dose without weight adjustment, as is usually done for other vasodilators. The investigators ...
Effects of vasodilator therapy for severe pump failure in acute myocardial infarction on short-term and late prognosis. |...
Forty-three patients with severe pump failure complicating acute myocardial infarction were treated with vasodilators (nitroprusside (40) and phentolamine (3)) for four hours to 27 days. Cardiac index, stroke volume index, and stroke work index (SWI) increased while the left ventricular filling pressure (LVFP) decreased during vasodilator therapy. Twenty-four of the 43 patients (56%) survived. Of patients with initial SWI between 11-20 gm-m/m2 and LVFP less than 15 mm Hg, 68% survived. In contrast only 18% of patients with SWI of 10 gm-m/m2 or less and LVFP greater than 15 mm Hg survived. Of the 17 patients with clinical shock, 8 (47%) survived. All 24 patients discharged from the hospital were followed for at least 12 months. Fourteen patients died one to 25 months (average 9.2 months) after discharge and the cause of death was pump failure in ten of them (71%). The ten survivors at last follow-up had been followed for 15 to 32 months (average 24 months). The cumulative survival at 24 months ...
Parasympathetic cholinergic vasodilator fibers | definition of parasympathetic cholinergic vasodilator fibers by Medical...
Looking for online definition of parasympathetic cholinergic vasodilator fibers in the Medical Dictionary? parasympathetic cholinergic vasodilator fibers explanation free. What is parasympathetic cholinergic vasodilator fibers? Meaning of parasympathetic cholinergic vasodilator fibers medical term. What does parasympathetic cholinergic vasodilator fibers mean?
Trimetazidine: a meta-analysis of randomised controlled trials in heart failure | Heart
We performed a meta-analysis of RCT evaluating the effect of trimetazidine compared with placebo control on cardiac function variables, clinical symptoms and major adverse events in patients with chronic HF. We found trimetazidine treatment resulted in better cardiac function for ischaemic and non-ischaemic HF, and improved clinical symptoms. More importantly, trimetazidine was associated with a significant reduction in the RR for mortality, cardiovascular events and hospitalisation.. Trimetazidine is initially used as an anti-ischaemic or cytoprotective agent through a metabolic pathway: switching cardiac metabolism from FFA to glucose oxidation, which is efficient in terms of oxygen consumption and energy production. Because FFA inhibitors can act as metabolic modulators in protecting the ischaemic myocardium, the effects of trimetazidine on HF have previously been assessed mainly in patients with ischaemic HF. The results of several small RCT have revealed improved cardiac function with ...
Vasodilation. | Annals of Internal Medicine | American College of Physicians
Forty-seven papers on the mechanisms whereby natural regulatory phenomena and synthetic vasodilator agents effect vasodilation. Outlines the complexity of the physiologic regulation of vascular smooth muscle tone and provides different points of view on debated issues. From a symposium, Mechanisms of Vasodilation, held July 1980 in Belgium. Five sections: neurohumoral regulation, local regulation, cellular mechanisms, the blood-vessel wall in hypertension, and vasodilator agents. ...
Elantan Long - Vasodilator Agents, Nitrates and Nitrites, Nitric Oxide Donors, ATC:C01DA14
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement ...
Conpin Retardkaps - Vasodilator Agents, Nitrates and Nitrites, Nitric Oxide Donors, ATC:C01DA14
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement ...
Nitrocot (Nitroglycerin) Oral / Sublingual: Uses, Dosage & Side Effects
The principal pharmacological action of isosorbide dinitrate is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Most controlled trials of multiple-dose oral ISDN taken every 12 hours or more frequently for several weeks have shown statistically significant anti-anginal efficacy for only 2 hours after dosing.. In clinical trials, immediate-release oral isosorbide dinitrate has been administered in a variety of regimens, with total daily doses ranging from 30 mg to mg. Attempts to overcome nitrate tolerance by dose escalation, even to doses far in excess of those used acutely, have consistently failed.. As with all titratable drugs, it is important to administer the minimum dose which produces the desired clinical effect. No data are available to suggest physiological maneuvers e. Dilatation of the coronary arteries also occurs.. Isordil Titradose is contraindicated in patients who are allergic to isosorbide dinitrate or any ...
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Congestive Heart Failure (CHF) and Vasodilators | FoundHealth
hydralazine - oi
n. a vasodilator drug used, usually in conjunction with diuretics, to treat hypertension. It is given by mouth or by intravenous injection or infusion; side-effects, including rapid heart rate, headache, faintness, and digestive upsets, can occur, especially at high doses. Trade name: Apresoline. ...
Trimetazidine Side Effects
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Nitroglycerin - Nitroglycerin - Pharmacology - Picmonic for Medicine
Vasodilation synonyms, vasodilation antonyms - FreeThesaurus.com
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Rosendorff C (1993). "Beta-blocking agents with vasodilator activity". Journal of Hypertension. Supplement. 11 (4): S37-40. doi ... Agents specifically labeled for migraine prophylaxisTimolol, propranolol Propranolol is the only agent indicated for control of ... Agents specifically labeled for cardiac arrhythmia Esmolol, sotalol, landiolol (Japan) Agents specifically labeled for ... depending on the concentration of the agent (beta blocker) and the concentration of the antagonized agent (usually an ...
... the antihypertension agent reserpine; the cholinomimeric galatamine; the spasmolysis agent atropine; the vasodilator vincamine ... Most bioactive compounds of natural origin are secondary metabolites, i.e., species-specific chemical agents that can be ... Balick, MJ (1990). "Ethnobotany and the identification of therapeutic agents from the rainforest". In Anonymous. Bioactive ... grouped into various categories. A typical protocol to isolate a pure chemical agent from natural origin is ...
... (pyridylcarbinol) is a niacin derivative used as a hypolipidemic agent and as a vasodilator. It causes ... Norwood WF (1963). "Vasodilator Effects of Nicotinyl Tartrate (Roniacol Tartrate)". JAMA. 186: 1013. PMID 14066712. "Ronicol ... Nicotinic acid is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes ...
Management of heart failure
Drugs used include: diuretic agents, vasodilator agents, positive inotropes, ACE inhibitors, beta blockers, and aldosterone ... The inotropic agent dobutamine is advised only in the short-term use of acutely decompensated heart failure, and has no other ... The combination of isosorbide dinitrate/hydralazine is the only vasodilator regimen, other than ACE inhibitors or angiotensin ...
Representative agents include bromoform and dibromodimethylhydantoin ("DBDMH"). Some herbicides, such as bromoxynil, contain ... Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the ... Alkyl bromine compounds are often alkylating agents and the brominated aromatic derivatives are implicated as hormone ... alkyl bromides are alkylating agents. Carbon-halogen bond strengths, or bond dissociation energies are of 115, 83.7, 72.1, and ...
Cardiac stress test
Commonly used agents include: Vasodilators acting as adenosine receptor agonists, such as adenosine itself, and dipyridamole ( ... Pharmacological stimulation from vasodilators such as dipyridamole or adenosine, or positive chronotropic agents such as ... Vasodilators are used to dilate coronary vessels, which causes increased blood velocity and flow rate in normal vessels and ... Pharmacologic agents such as Adenosine, Lexiscan (Regadenoson), or dipyridamole is generally used when a patient cannot achieve ...
Exhaled nitric oxide
In the latter condition, inhaled NO is used as a diagnostic test of the response of the pulmonary arteries to vasodilators ( ... Today, NO is not only used in breath tests but also as a therapeutic agent for conditions such as pulmonary arterial ... agents that relax the blood vessels). Exposure to air pollution has been associated with decreased, and increased eNO levels. ...
Conversely, the bromide ion is a weaker reducing agent than iodide, but a stronger one than chloride. These similarities ... Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the ... When a lower bromide is wanted, either a higher halide may be reduced using hydrogen or a metal as a reducing agent, or thermal ... Like all halogens, it is thus one electron short of a full octet, and is hence a strong oxidising agent, reacting with many ...
Inotropic Agents, Vasodilators, Nitrates, B-type Natriuretic Peptides, I(f) Inhibitors, ARNIs, Diuretics, Loop, Diuretics, ... The goal in using these pharmacologic agents is to decrease the afterload so that the left ventricle is somewhat spared. The ... Medical therapy of chronic aortic insufficiency that is stable and asymptomatic involves the use of vasodilators. Trials have ...
... with the vasoactive pharmacological agents (vasoconstrictors or vasodilators and/or ACE Inhibitors and/or ARBs)(ACE = ... cardioactive or vasoactive agents. The measurement of CI and its derivatives allow clinicians to make timely patient assessment ... Pharmacological modulation of contractility is performed with cardioactive inotropic agents (positive or negative inotropes) ...
Class II agents (e.g., amlodipine, nifedipine), or the Class III agent diltiazem. Nifedipine is more a potent vasodilator and ... Class I agents have the most potent negative inotropic effect and may cause heart failure. Class II agents do not depress ... Class III agent has negligible inotropic effect and causes almost no reflex tachycardia. Examples include Class I agents (e.g ... Agents include either cardioselectives such as acebutolol or metoprolol, or non-cardioselectives such as oxprenolol or sotalol ...
... is also used as a flavoring agent. It has been found as a volatile component in pineapples and Beaufort cheese ... Examples are the hypnotic glutethimide or the vasodilator vincamin (obsolete by now) or more recent therapeutics such as the ... COPD agent cilomilast or the nootropic leteprinim. With dienes ethyl acrylate reacts as a good dienophile in Diels-Alder ...
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Sensorineural hearing loss
vitamins and antioxidants vasodilators betahistine (Betaserc), an anti-vertigo drug hyperbaric oxygen anti-inflammatory agents ... Methotrexate, a chemotherapy agent, is also known to cause hearing loss. In most cases hearing loss does not recover when the ... It is classified as a vasodilator. Among its research uses is treatment of sensorineural deafness and tinnitus presumed to be ... and ototoxic agents. The intrinsic component indicates the wear-and-tear effects of exposure to the everyday sounds of normal ...
Vasodilators are also typically ineffective because systolic function is usually preserved in cases of RCM. Heart failure ... Digoxin, calcium channel blocking drugs and beta-adrenergic blocking agents provide little benefit, except in the subgroup of ... "Worsening of congestive heart failure in amyloid heart disease treated by calcium channel-blocking agents". American Journal of ...
In the United States, this agent is only available in the oral form and is typically given in hospital settings. Diazoxide is ... van Hamersvelt HW, Kloke HJ, de Jong DJ, Koene RA, Huysmans FT (August 1996). "Oedema formation with the vasodilators ... doi:10.1016/0006-2952(89)90327-4. Doyle, Máire E.; Egan, Josephine M. (2003-03-01). "Pharmacological Agents That Directly ... used as a vasodilator in the treatment of acute hypertension or malignant hypertension. Diazoxide also inhibits the secretion ...
For over 130 years, nitroglycerin has been used medically as a potent vasodilator (dilation of the vascular system) to treat ... The percentage varies with the desensitizing agent used.) Desensitization requires extra effort to reconstitute the "pure" ... These agents all exert their effect by being converted to nitric oxide in the body by mitochondrial aldehyde dehydrogenase, and ... of ischemic heart disease caused by inadequate flow of blood and oxygen to the heart and as a potent antihypertensive agent. ...
In medicine for over 130 years, nitroglycerin has been used as a potent vasodilator (dilation of the vascular system) to treat ... The percentage varies with the desensitizing agent used.) Desensitization requires extra effort to reconstitute the "pure" ... These agents all exert their effect by being converted to nitric oxide in the body by mitochondrial aldehyde dehydrogenase ( ... ALDH2), and nitric oxide is a potent natural vasodilator. In medicine, nitroglycerin is used for angina pectoris, a painful ...
PG-X, which later would become known as prostacyclin, was 30 times more potent than any other known anti-aggregatory agent.[ ... Since treprostinil is a vasodilator, its antihypertensive effect may be compounded by other medications that affect the blood ... is a vasodilator that is used for the treatment of pulmonary arterial hypertension. Treprostinil is a synthetic analog of ... pressure, including calcium channel blockers, diuretics, and other vasodilating agents. Because of treprostinil's inhibiting ...
Prazosin was synthesized in 1974 when Constantin and Hess were trying to discover a vasodilator which had a minimal effect on ... Alpha-1 blockers (also called alpha-adrenergic blocking agents) constitute a variety of drugs that block alpha-1-adrenergic ... Because these medications may cause orthostatic hypotension, as well as low blood pressure in general, these agents may ... Since alpha-1 blockers may cause orthostatic hypotension, co-administration with antihypertensives and vasodilators must be ...
Vasodilators such as sodium nitroprusside can be considered for people with ongoing high blood pressure, but they should never ... In acute dissection, fast-acting agents which can be given intravenously and have doses that are easier to adjust (such as ... The calcium channel blockers typically used are verapamil and diltiazem, because of their combined vasodilator and negative ... persistent hypertension on the maximum doses of three different classes of antihypertensive agents), an involvement of the ...
On the other hand, the long-term effect is due to an unknown vasodilator effect that decreases blood pressure by decreasing ... The term "calcium-sparing diuretic" is sometimes used to identify agents that result in a relatively low rate of excretion of ... Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug which reduces the excretion of ... Diuretics increase the urine volume and dilute doping agents and their metabolites. Another use is to rapidly lose weight to ...
Stewart JM (2003). "Bradykinin antagonists as anti-cancer agents". Current Pharmaceutical Design. 9 (25): 2036-42. doi:10.2174/ ... Bradykinin is a potent endothelium-dependent vasodilator, leading to a drop in blood pressure. It also causes contraction of ... The differential vasoconstriction of these fetal vessels compared to the vasodilator response of other vessels suggest that the ... and bradykinin antagonists have been investigated as anti-cancer agents. ...
antifungal, alkalinizing agents, quinolones, antibiotics, cholinergics, anticholinergics, antispasmodics, 5-alpha reductase ... vasodilators. ... In the inter-war period, the first anti-bacterial agents such ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ... HMG-CoA reductase inhibitors (statins) for lowering LDL cholesterol inhibitors: hypolipidaemic agents. ...
These agents increase the level of aminopeptidase P, an enzyme that inactivates kinins; kinins (especially bradykinin) are ... Bradykinin plays a critical role in all forms of hereditary angioedema. This peptide is a potent vasodilator and increases ... Consumption of foods which are themselves vasodilators, such as alcoholic beverages or cinnamon, can increase the probability ... The version related to histamine is due to an allergic reaction to agents such as insect bites, foods, or medications. The ...
NGF has not been found in human saliva; however, researchers find human saliva contains such antibacterial agents as secretory ... which is a vasodilator; it is secreted by the acinar cells of all three major salivary glands ... antimicrobial agents such as secretory IgA and lysozyme. The enzymes found in saliva are essential in beginning the process ... "Antimicrobial Agents in Saliva-Protection for the Whole Body". Journal of Dental Research. 81 (12): 807-809. doi:10.1177/ ...
Psychotropic agents. Other psychotropic analgesic agents include ketamine (an NMDA receptor antagonist), clonidine and ... Vasodilators. *Beta blockers. *Calcium channel blockers. *renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor ... Unselective agents Aceclofenac. Comes in betadex salt and free acid forms; practically insoluble in water, soluble in many ... Other agents directly potentiate the effects of analgesics, such as using hydroxyzine, promethazine, carisoprodol, or ...
It may be used as a nasal/sinus decongestant, as a stimulant, or as a wakefulness-promoting agent. ... Vasodilators. *Beta blockers. *Calcium channel blockers. *renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor ... Tashkin, D. P. (1 March 2001). "Airway effects of marijuana, cocaine, and other inhaled illicit agents". Current Opinion in ... and anorectic agent. It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary ...
Calcium channel blocker
While most of the agents listed above are relatively selective, there are additional agents that are considered nonselective. ... By having both cardiac depressant and vasodilator actions, benzothiazepines are able to reduce arterial pressure without ... The negative chronotropic effects of CCBs make them a commonly used class of agents in individuals with atrial fibrillation or ... For severe overdoses, treatment usually includes close monitoring of vital signs and the addition of vasopressive agents and ...
Available agents. Main article: List of antineoplastic agents. There is an extensive list of antineoplastic agents. ... Alkylating agents. Main article: Alkylating antineoplastic agent. Alkylating agents are the oldest group of ... Vasodilators. *Beta blockers. *Calcium channel blockers. *renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor ... Siddik ZH (2005). Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA-Interactive Alkylating Agents and Antitumour ...
List of agents. Adrenaline releasing agents. Main article: Norepinephrine releasing agent ... Vasodilators. *Beta blockers. *Calcium channel blockers. *renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor ... 3 List of agents *3.1 Adrenaline releasing agents *3.1.1 Common or widely marketed ... since these agents lose effectiveness after a few days. ...
ಟೆಂಪ್ಲೇಟು:Central nervous system navs - ವಿಕಿಪೀಡಿಯ
It may play a role as potential therapeutic agent.. Microbiology. Carbon monoxide is a nutrient for methanogenic ... In many tissues, all three gases are known to act as anti-inflammatories, vasodilators, and promoters of neovascular growth.[16 ... In many tissues, all three gases are known to act as anti-inflammatories, vasodilators, and encouragers of neovascular growth.[ ... Carbon monoxide is a strong reductive agent, and whilst not known, it has been used in pyrometallurgy to reduce metals from ...
Nitric oxide synthase
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Functional magnetic resonance imaging
This too often uses an external agent. Calcium-sensitive agents make MRI more sensitive to calcium concentrations, with calcium ... Nitric oxide is a vasodilator causing arterioles to expand and draw in more blood. ... It uses 7 T fields, small-bore scanners that can fit small animals such as rats, and external contrast agents such as fine iron ... Since the internal contrast is too difficult to measure, external agents such thulium compounds are used to enhance the effect ...
"Dermatotherapeutic Agents". Ullmann's Encyclopedia of Industrial Chemistry (7th ed.). 2007. doi:10.1002/14356007.a08_301.pub2. ... Vasodilators. *Beta blockers. *Calcium channel blockers. *renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor ... Kyriakidis I, Tragiannidis A, Munchen S, Groll AH (February 2017). "Clinical hepatotoxicity associated with antifungal agents ... "The cost effectiveness of testing for onychomycosis versus empiric treatment of onychodystrophies with oral antifungal agents ...
These agents are more properly termed thiazide-like diuretics. Thiazide diuretics also increase calcium reabsorption at the ... or direct vasodilator actions either through inhibition of carbonic anhydrase or by desensitizing the vascular smooth muscle ... Very few agents used for the treatment of any disease can boast such staying power, which is a testament both to the efficacy ... as first line agents in hypertension and advise that thiazide-like diuretics should only be used first line if CCBs are not ...
Within the class of medications, there is no clear evidence that one agent works better than another. ... Vasodilators. *Beta blockers. *Calcium channel blockers. *renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor ... In British Columbia, Canada the cost of the PPIs varies significantly from 0.20 CAD to 2.38 CAD per dose while all agents in ... The cost between different agents varies significantly. ...
Wikipedia:WikiProject Medicine/Cochrane/Cochrane Review List/Musculoskeletal, Oral, Skin and Sensory
Topical agents or dressings for pain in venous leg ulcers PMID 23152206 https://doi.org/10.1002/14651858.CD001177.pub3 ... Vasodilators and vasoactive substances for idiopathic sudden sensorineural hearing loss PMID 19821308 https://doi.org/10.1002/ ... Dressings and topical agents for surgical wounds healing by secondary intention PMID 15106207 https://doi.org/10.1002/14651858. ... Topical antimicrobial agents for treating foot ulcers in people with diabetes PMID 28613416 https://doi.org/10.1002/14651858. ...
Rosendorff C (June 1993). "Beta-blocking agents with vasodilator activity". Journal of Hypertension Supplement. 11 (4): S37-40 ... Agents specifically labeled for glaucoma *Betaxolol, carteolol, levobunolol, timolol, metipranolol ... Agents with intrinsic sympathomimetic action (ISA) *Acebutolol, pindolol, labetalol, mepindolol, oxprenolol,[75 ... depending on the concentration of the agent (beta blocker) and the concentration of the antagonized agent (usually an ...
As a vasodilator in severe Raynaud's phenomenon or ischemia of a limb ... but also neutralized the changes of the retina and the choroid thickness caused by the injection of pro-inflammatory agents. ... Prostaglandins are powerful locally acting vasodilators and inhibit the aggregation of blood platelets. Through their role in ...
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Reducing agent (antioxidant), e.g. if epinephrine is used, then sodium metabisulfite is used as a reducing agent ... Vasodilators. *Beta blockers. *Calcium channel blockers. *renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor ... LA drugs are also often combined with other agents such as opioids for synergistic analgesic action. Low doses of LA drugs ... This can be a factor in choosing an agent in patients with liver failure, although since cholinesterases are produced in ...
Age-related differences in the β-adrenergic vasodilator response in rat aortic rings<...
Age-related differences in the β-adrenergic vasodilator response in rat aortic rings. / Castillo-Hernandez, Maria Del Carmen; ... Age-related differences in the β-adrenergic vasodilator response in rat aortic rings. In: Proceedings of the Western ... Age-related differences in the β-adrenergic vasodilator response in rat aortic rings. Proceedings of the Western Pharmacology ... Mechanisms underlying age-dependent changes in vasodilator responses to β-adrenergic drugs are poorly understood. The aim of ...
Block 3: vasodilators Flashcards - Cram.com
... vasodilators at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want! ... central sympatholytic agent (alpha 2 agonist)- acts centrally to reduce sympathetic activity by depleting neuronal stores of ... ":"Block 3: vasodilators","payreferer_url":"\/flashcards\/copy\/block-3-vasodilators-278830","isGuest":true,"ga_id":"UA-272909- ...
Vasodilator Agents | Encyclopedia.com
Purpose Vasodilators are used to treat high blood pressure  (hypertension ). ... Vasodilators Definition Vasodilators are medicines that act directly on muscles in blood vessel walls to make blood vessels ... Vasodilators. Definition. Vasodilators are medicines that act directly on muscles in blood vessel walls to make blood vessels ... Examples of vasodilators are hydralazine (Apresoline) and minoxidil (Loniten). The vasodilator hydralazine also may be used to ...
Vasodilator Agents | GreenMedInfo | Pharmacological Action | Natural
Antifungal Agents, Antihypertensive Agents, Antimalarials, Antimicrobial, Neuroprotective Agents, Vasodilator Agents ... Pharmacological Actions : Antihypertensive Agents, Antioxidants, Cardiovascular Agents, Cytoprotective, Vasodilator Agents. ... Pharmacological Actions : Anti-Inflammatory Agents, Vasodilator Agents. Additional Keywords : Gene Expression Regulation, Plant ... Pharmacological Actions : Antihypertensive Agents, Nitric Oxide Inhibitor, Vasodilator Agents. Additional Keywords : Plant ...
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Prostacyclin and acetylcholine as screening agents for acute pulmonary vasodilator responsiveness in primary pulmonary...
3-8 agents/patient); the administration of the different agents was timed to avoid synergistic effects. Of all the agents ... Prostacyclin and acetylcholine as screening agents for acute pulmonary vasodilator responsiveness in primary pulmonary ... Prostacyclin and acetylcholine as screening agents for acute pulmonary vasodilator responsiveness in primary pulmonary ... Prostacyclin and acetylcholine as screening agents for acute pulmonary vasodilator responsiveness in primary pulmonary ...
Esophageal Motility Disorders Medication: Calcium channel blockers, Vasodilators, Anticholinergics, Anxiolytics, Tricyclic...
The Effect of Thrombolytic, Anticoagulant, and Vasodilator Agents on the Survival of Random Pattern Skin Flap. | Sigma-Aldrich
The Effect of Thrombolytic, Anticoagulant, and Vasodilator Agents on the Survival of Random Pattern Skin Flap.. [Mübin Aral, ... Subcutaneously applied thrombolytic, anticoagulant, and vasodilator agents increase random-pattern skin flap survival with only ... and vasodilator agents on the survival of random-pattern skin flap. A caudally based dorsal flap model was used in 24 rats in ...
6-Benzoxazinylpyridazin-3-ones: Potent, Long-Acting Positive Inotrope and Peripheral Vasodilator Agents
Myocardial Infarction Medication: Antiplatelet Agents, Antithrombotic Agents, Glycoprotein IIb/IIIa Inhibitors, Vasodilators,...
Antiplatelet Agents. Class Summary. Antiplatelet agents have a strong mortality benefit. There is an increased risk of bleeding ... Vasodilators. Class Summary. Vasodilators relieve chest discomfort by improving myocardial oxygen supply, which in turn dilates ... Antithrombotic Agents. Class Summary. Antithrombotic agents, which include heparin, bivalirudin, and enoxaparin, prevent the ... This agent is indicated to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome (ACS)- ...
Pulmonary Vasodilator Therapy in the NICU: Inhaled Nitric Oxide, Sildenafil, and Other Pulmonary Vasodilating Agents | Lurie...
Resistant Hypertension in the Elderly-Second Line Treatments: Aldosterone Antagonists, Central Alpha-Agonist Agents, Alpha...
Central Alpha-Agonist Agents, Alpha-Adrenergic Receptor Blockers, Direct Vasodilators, and Exogenous Nitric Oxide Donors", ... central agents, alpha blockers, direct vasodilating agents, and exogenous nitric oxide donors. These antihypertensive drugs are ... central agents, alpha blockers, direct vasodilating agents, and exogenous nitric oxide donors. These antihypertensive drugs are ... Cardiovascular & Hematological Agents in Medicinal Chemistry Title:Resistant Hypertension in the Elderly-Second Line Treatments ...
Downloadable Document - Vasodilator Agents | GreenMedInfo | Natural
54 Curated Medical Research astracts associated with Vasodilator Agents. FRIEND membership. $8 / month $75 / year FRIEND USER ... PRO MEMBERS get Unlimited Access to downloadable documents like this, with curated research on Vasodilator Agents. ... Some Example Abstracts on Vasodilator Agents. Resveratrol may positively modulate cerebral blood flow variables.. ... Pharmacological Actions : Nitric Oxide Enhancer : CK(190) : AC(47), Vasodilator Agents : CK(347) : AC(74) ...
Gulliostin - Vasodilator Agents, ATC:B01AC07
Search of: child psychiatry - Results by Topic - ClinicalTrials.gov
Intra-arterial vasodilators for vasospasm following aneurysmal subarachnoid hemorrhage: a meta-analysis. - PubMed - NCBI
Vasodilator Agents/administration & dosage*. *Vasospasm, Intracranial/diagnostic imaging. *Vasospasm, Intracranial/drug therapy ... Intra-arterial vasodilators for vasospasm following aneurysmal subarachnoid hemorrhage: a meta-analysis.. Venkatraman A1, ... The efficacy of intra-arterial vasodilators (IADs) for the treatment of vasospasm following aneurysmal subarachnoid hemorrhage ...
Acetyl-l-carnitine | GreenMedInfo | Substance | Natural Medicine
Myocardial Infarction Therapeutics Market Analysis (Analgesics, Antiplatelet agents, Vasodilators, Thrombolytics and anti...
Antiplatelet agents. • Vasodilators. • Thrombolytics and anti-thrombotic agents. • Glycoprotein IIb/IIIa inhibitors. • Β ... Analgesics and antiplatelet agents segments are expected to hold more share in this market as these agents are used for initial ... Myocardial Infarction Therapeutics Market Analysis (Analgesics, Antiplatelet agents, Vasodilators, Thrombolytics and anti- ... thrombotic agents, Glycoprotein IIb/IIIa inhibitors) Trends & Forecast to 2022. Posted on May 10, 2016. ...
Agents with vasodilator properties in acute heart failure: how to design successful trials - Urgences Lariboisière
Agents with vasodilator properties in acute heart failure: how to design successful trials. Alexandre Mebazaa1,2,3*, Dan ... Abstract: Agents with vasodilator properties (AVDs) are frequently used in the treatment of acute heart failure (AHF). AVDs ... Agents with vasodilator properties in acute heart failure: how to design successful trials ...
... has role tocolytic agent (CHEBI:66993) nitroglycerin (CHEBI:28787) has role vasodilator agent ( ... vasodilator agent A drug used to cause dilation of the blood vessels. ... tocolytic agent Any compound used to suppress premature labour and immature birth by suppressing uterine contractions. ... An agent, with unique chemical structure and biochemical requirements, which generates nitric oxide. ...
Hand ischemia after radial artery cannulation. - PubMed - NCBI
Vasodilator Agents/therapeutic use. *Veins/transplantation. Substance. *Vasodilator Agents. LinkOut - more resources. Full Text ... Nonoperative therapy with vasodilators can be equally effective in treating cannula-induced radial artery injuries in some ... two others were treated nonoperatively with vasodilators, and one was observed without treatment. Three of the four patch ...
Comparative haemodynamic and metabolic effects of vasodilator and inotropic agents in experimental myocardial infarction<...
Therefore vasodilators may be more beneficial than inotropic agents in acute myocardial infarction. ... Therefore vasodilators may be more beneficial than inotropic agents in acute myocardial infarction.", ... Therefore vasodilators may be more beneficial than inotropic agents in acute myocardial infarction. ... Therefore vasodilators may be more beneficial than inotropic agents in acute myocardial infarction. ...
Brachial artery diameter and vasodilator response to nitroglycerine, but not flow-mediated dilatation, are associated with the...
0/Vasodilator Agents; 55-63-0/Nitroglycerin; 7440-70-2/Calcium From MEDLINE®/PubMed®, a database of the U.S. National Library ... Brachial artery diameter and vasodilator response to nitroglycerine, but not flow-mediated dilatation, are associated with the ... We conclude that greater diameter of the brachial artery and lower vasodilator response to nitroglycerine, but not FMD, are ...
5-Fluorouracil cardiotoxicity: left ventricular dysfunction and effect of coronary vasodilators.
Nutrienr intake from food, calorie intake, and body | bartleby
Indicate whether or not each of the following compounds | bartleby
A Study of Semen Characteristics After 9 Months of Daily Tadalafil 20 mg - Full Text View - ClinicalTrials.gov
RCSB PDB - ADN Ligand Summary Page
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia - Full Text View - ClinicalTrials.gov
Effects of Sildenafil in Resistant Hypertensives and Genetic Polymorphism - Full Text View - ClinicalTrials.gov
Vasodilator Agents. Phosphodiesterase 5 Inhibitors. Phosphodiesterase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of ... Urological Agents. Bronchodilator Agents. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. ... Anti-Asthmatic Agents. Respiratory System Agents. Free Radical Scavengers. Antioxidants. Neurotransmitter Agents. Endothelium- ... However, it is unknown if the simultaneous use of sildenafil plus, at least, 3 classes of antihypertensive agents in patients ...
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure:...
AorticDiureticsPotentHypertensionAntihypertensive agentsPharmacologyDilation of the blood vesselsVasodilationMyocardial perfusionTherapeuticProstacyclinNitricArterialBlood vesselsInotropic agentNitroprussideCalciumAnticoagulantsProstaglandinLowers blood pressureNifedipineApresolineSubstanceCardiotonic agentTherapyHydralazineInhibitsThrombolyticDipyridamoleAnticoagulantAnesthetic AgentsEffectsPatient'sDrugsStrokeBiochemicalPatientsVasoactiveAcute myocardialHemodynamic parametersSevereHypotensionMechanismsDiameterEfficacyTreatment
- An appropriate therapy for RH can be achieved by the addition of second line antihypertensive drugs: antialdosteronic diuretics, central agents, alpha blockers, direct vasodilating agents, and exogenous nitric oxide donors. (eurekaselect.com)
- Short-term management of CHF in patients whose condition can be closely monitored and who have not responded adequately to digitalis, diuretics, or vasodilators. (drugs.com)
- Captopril is effective alone and in combination with other antihypertensive agents, especially thiazide -type diuretics . (wikidoc.org)
- Antihypertensive agents include diuretics, alpha-adrenergic and beta-adrenergic antagonists, angiotensin-converting enzyme inhibitors, calcium channel blockers, ganglionic blockers, and vasodilator agents. (fpnotebook.com)
- 6-[3,4-Dihydro-3-oxo-1,4(2H)-benzoxazin-7-yl]-2,3,4,5-tetrahydro-5 - methylpyridazin-3-one (bemoradan) was found to be an extremely potent and selective inhibitor of canine PDE fraction III and a long-acting, potent, orally active inotropic vasodilator agent in various canine models. (nih.gov)
- Adenosine is a potent vasodilator in most vascular beds, but vasoconstriction is produced in renal afferent arterioles and hepatic veins. (rcsb.org)
- A potent vasodilator agent with calcium antagonistic action. (fpnotebook.com)
- In conclusion, inhaled iloprost is a potent pulmonary vasodilator in human immune deficiency virus-related pulmonary hypertension. (ersjournals.com)
- Being potent vasodilator agents, these drugs are widely used as antihypertensive drugs. (frontiersin.org)
- Prostacyclin and acetylcholine as screening agents for acute pulmonary vasodilator responsiveness in primary pulmonary hypertension. (ahajournals.org)
- We conclude that in the majority of patients with primary pulmonary hypertension, acetylcholine appears to be an effective and available substitute for prostacyclin in screening for pulmonary vasodilator responsiveness. (ahajournals.org)
- Carlos G. Musso and Jose Alfie, "Resistant Hypertension in the Elderly-Second Line Treatments: Aldosterone Antagonists, Central Alpha-Agonist Agents, Alpha-Adrenergic Receptor Blockers, Direct Vasodilators, and Exogenous Nitric Oxide Donors", Cardiovascular & Hematological Agents in Medicinal Chemistry (2014) 12: 170. (eurekaselect.com)
- However, it is unknown if the simultaneous use of sildenafil plus, at least, 3 classes of antihypertensive agents in patients with resistant arterial hypertension may have a synergic effect on the patients blood pressure. (clinicaltrials.gov)
- Effects of different pulmonary vasodilators on arterial saturation in a model of pulmonary hypertension. (nih.gov)
- Treatment of pulmonary hypertension (PH) with NO-releasing agents such as nitrates has failed to produce beneficial long-term effects as, in most cases, negligible pulmonary vasodilatation was counterbalanced by significant peripheral reduction in vascular resistance and reflex tachycardia 14 , which are poorly tolerated by patients with severe PH. (ersjournals.com)
- Abstract -The protective effect of vasodilator agents linked to the cAMP pathway is less effective for buffering the vasoconstrictor effect of angiotensin II in young animals with genetic hypertension. (ahajournals.org)
- An imbalance between vasodilator and vasoconstrictor systems may contribute to pathogenesis and maintenance of hypertension. (ahajournals.org)
- These involve using antiplatelet therapy with aspirin or clopidogrel, controlling hypertension, managing hypercholesterolemia, and using vasodilators such as cilostazol. (elsevier.com)
- A calcium channel blocker drug, C 22 H 26 N 2 O 4 S, that acts as a coronary vasodilator and is used in the form of its hydrochloride to treat angina pectoris and hypertension. (thefreedictionary.com)
- It follows that the kidney is the most likely target for the action of most effective antihypertensive agents used chronically in clinical practice today. (frontiersin.org)
- Here we review the long-term renal actions of antihypertensive agents in human studies and find three different mechanisms of action for the drugs investigated. (frontiersin.org)
Dilation of the blood vessels1
- Of all the agents tested, prostacyclin and acetylcholine were most consistently effective in evoking acute pulmonary vasodilation, and both seemed to distinguish patients capable of manifesting acute pulmonary vasodilation from those who were not. (ahajournals.org)
- For example, normal buffering is provided by agents such as acetylcholine or bradykinin that primarily produce vasodilation through endothelial activation of the nitric oxide-cGMP pathway. (ahajournals.org)
- Forty-seven papers on the mechanisms whereby natural regulatory phenomena and synthetic vasodilator agents effect vasodilation. (annals.org)
- a calcium-channel blocking agent used to produce peripheral and coronary vasodilation in the management of heart disease. (thefreedictionary.com)
- Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis. (pharmacycode.com)
- Explain to interested patients that a study of two vasodilator agents in myocardial perfusion imaging showed that regadenoson (renally excreted) caused less of an increase in heart rate in patients with end-stage renal disease compared to adenosine. (medpagetoday.com)
- The use of vasodilator myocardial perfusion imaging in severe aortic stenosis: Is it time for a new prospective study? (springer.com)
- However, at maximal doses set by protocol, prostacyclin generally elicited a greater vasodilator response than acetylcholine. (ahajournals.org)
- Expression of the vasoconstrictor endothelin is increased, while production of vasodilators such as prostacyclin and nitric oxide (NO) is decreased 10 . (ersjournals.com)
- Vasodilators are medicines that act directly on muscles in blood vessel walls to make blood vessels widen (dilate). (encyclopedia.com)
- Amyl nitrite is one of the oldest vasodilators (i.e., agents that expand blood vessels). (britannica.com)
- a nerve or agent that causes dilation of blood vessels by promoting the relaxation of vascular smooth muscle. (thefreedictionary.com)
- An agent, such as a nerve or hormone, that widens the blood vessels, which in turn decreases resistance to blood flow and lowers blood pressure. (thefreedictionary.com)
- 2. a nerve or agent that causes dilatation of blood vessels. (thefreedictionary.com)
- Summary: Following coronary embolisation and onset of left ventricular failure 27 awake dogs were randomly assigned to infusion of saline (controls), nitroprusside, or dobutamine (a new inotropic agent). (umn.edu)
- Positive inotropic agent with vasodilator activity. (drugs.com)
- Milrinone, an inotropic agent used ubiquitously in children after cardiac surgery, accumulates in acute kidney injury (AKI). (bioportfolio.com)
- Brachial artery diameter and vasodilator response to nitroglycerine, but not flow-mediated dilatation, are associated with the presence and quantity of coronary artery calcium in asymptomatic adults. (biomedsearch.com)
- Nicardipine Hydrochloride is a vasodilator with 1,4-dihydropyridine-type calcium channel blocking activity. (mpbio.com)
- and even as of this writing, no oral calcium antagonist agent. (springer.com)
- The vast number of new beta blocker and calcium antagonist agents being developed, as well as the long-term use abroad of many new drugs, has raised important questions as to how relative safety and efficacy of such agents can be determined to facilitate availability in the United States. (springer.com)
- A dihydropyridine calcium channel blocking agent. (fpnotebook.com)
- calcium channel blocker used as a coronary vasodilator in the treatment of coronary insufficiency and angina. (fpnotebook.com)
- Inhaled NO is widely used as a short-term vasodilator to identify so-called responders to calcium channel blockers 15 . (ersjournals.com)
Lowers blood pressure1
- Nonoperative therapy with vasodilators can be equally effective in treating cannula-induced radial artery injuries in some patients. (nih.gov)
- Milrinone is an invaluable agent in the treatment of end-stage heart failure patients who are refractory to optimal medical therapy. (bioportfolio.com)
- The final chapter summarizes vasodilator therapy, its rationale, and the findings in studies of specific agents. (annals.org)
- Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. (pharmacycode.com)
- This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (fpnotebook.com)
- The Effect of Thrombolytic, Anticoagulant, and Vasodilator Agents on the Survival of Random Pattern Skin Flap. (sigmaaldrich.com)
- The aim of this study was to investigate the effect of subcutaneously applied thrombolytic, anticoagulant, and vasodilator agents on the survival of random-pattern skin flap. (sigmaaldrich.com)
- Subcutaneously applied thrombolytic, anticoagulant, and vasodilator agents increase random-pattern skin flap survival with only enoxaparin sodium showing significant decrease in flap necrosis. (sigmaaldrich.com)
- It is now becoming apparent that both cardioselective (regadenoson) and possibly non-selective (adenosine and dipyridamole) vasodilators are well tolerated by patients with severe aortic stenosis and the ischemic burden can be safely and accurately evaluated using non-invasive stress testing. (springer.com)
- The effects of taking vasodilators during pregnancy have not been specifically studied in humans. (encyclopedia.com)
- the administration of the different agents was timed to avoid synergistic effects. (ahajournals.org)
- both were equally well-tolerated, and side effects were mild and resolved rapidly when the vasodilator infusions were stopped. (ahajournals.org)
- Monitor for reduced effects of the antidiabetic agents. (nextbio.com)
- Which of the following is the antihypertensive agent that likely caused these adverse effects? (proprofs.com)
- We studied the effects of volume expansion and vasodilators in acute pericardial tamponade in spontaneously breathing mongrel dogs. (elsevier.com)
- Kerber, R. E. / Effects of volume expansion and vasodilators in acute pericardial tamponade . (elsevier.com)
- We have selected this topic with the aim to evaluate and compare the effects of diuretic, vasodilator therapies in Meniere's disease and also to compare these results with those mentioned in the literature so that a better regime of treatment can be formulated for the patients with Meniere's disease. (thefreedictionary.com)
- PHILADELPHIA -- The presence of end-stage renal disease may influence a patient's response to vasodilators used for perfusion stress testing, a single-center study showed. (medpagetoday.com)
- Stress scintigraphy can be performed with pharmacologic agents instead of exercise if the patient's condition does not allow sufficient physical activity for performing the study. (aafp.org)
- Vasodilators usually are prescribed with other types of blood pressure drugs and rarely are used alone. (encyclopedia.com)
- Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices. (nature.com)
- In the past, patients with severe aortic stenosis could not use vasodilators because they could cause blood pressure to drop too low and result in severe complications. (encyclopedia.com)
- This agent is indicated to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome (ACS)-that is, unstable angina, non-ST elevation MI (NSTEMI), or ST-elevation MI (STEMI). (medscape.com)
- Among the 120 patients with end-stage renal disease, however, reductions in systolic blood pressure were about equal with both agents (-19 mm Hg with adenosine and -20 with regadenoson). (medpagetoday.com)
- Despite the interaction between renal disease and hemodynamic response, she said the findings were reassuring because the drops in blood pressure and the changes in heart rate were similar with the two agents in patients with end-stage renal disease. (medpagetoday.com)
- Peterson and her colleagues looked at data from 4,253 patients who underwent perfusion imaging at their center for suspected coronary artery disease -- 2,370 required vasodilators. (medpagetoday.com)
- He said that regadenoson's use in end-stage renal disease patients is not on the drug's label, and thus the agent should not be used in this patient population. (medpagetoday.com)
- The findings of this study agree with the previous reports and suggest that vasodilators are well tolerated and can be used safely in patients with severe aortic stenosis. (springer.com)
- In both groups PH was moderate to severe and there was no response to acute vasodilator challenge. (bmj.com)
- In this issue of the journal, Hussain et al examined retrospectively the safety of vasodilator stress imaging in a population with severe aortic stenosis. (springer.com)
- The findings of this study are consistent with the prior reports, 3 , 4 , 5 , 6 , 7 which found that about 20% of individuals with severe aortic stenosis that underwent vasodilator stress test developed significant hypotension, and only the minority of those became symptomatic. (springer.com)
- Agents with vasodilator properties (AVDs) are frequently used in the treatment of acute heart failure (AHF). (urgenceslariboisiere.com)
- two others were treated nonoperatively with vasodilators, and one was observed without treatment. (nih.gov)
- With the beginning of the 1980's it was becoming increasingly evident that the lack of approval of new cardiovascular agents for use by clinicians in the United States for the treatment of cardiovascular disorders was becoming a problem. (springer.com)