Vasodilator agents. Medical search

Drugs used to cause dilation of the blood vessels.

An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.

A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.

The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.

A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.

The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

The flow of BLOOD through or around an organ or region of the body.

A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.

Part of the arm in humans and primates extending from the ELBOW to the WRIST.

Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.

A direct-acting vasodilator that is used as an antihypertensive agent.

A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.

The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.

The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.

PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.

A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).

Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.

Drugs used to cause constriction of the blood vessels.

Arteries which arise from the abdominal aorta and distribute to most of the intestines.

The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).

The circulation of blood through the CORONARY VESSELS of the HEART.

The circulation of the BLOOD through the LUNGS.

A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.

The veins and arteries of the HEART.

The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.

The circulation of blood through the BLOOD VESSELS supplying the abdominal VISCERA.

A competitive inhibitor of nitric oxide synthetase.

An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.

The relationship between the dose of an administered drug and the response of the organism to the drug.

The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

An essential amino acid that is physiologically active in the L-form.

The smallest divisions of the arteries located between the muscular arteries and the capillaries.

Paracrine substances produced by the VASCULAR ENDOTHELIUM with VASCULAR SMOOTH MUSCLE relaxation (VASODILATION) activities. Several factors have been identified, including NITRIC OXIDE and PROSTACYCLIN.

Recording of change in the size of a part as modified by the circulation in it.

The nonstriated involuntary muscle tissue of blood vessels.

A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.

The circulation of the BLOOD through the vessels of the KIDNEY.

A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)

A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.

An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)

A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)

A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)

The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.

A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.

The vessels carrying blood away from the heart.

Endogenously-synthesized compounds that influence biological processes not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS.

The circulation of the BLOOD through the MICROVASCULAR NETWORK.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.

The number of times the HEART VENTRICLES contract per unit of time, usually per minute.

Compounds with a core of fused benzo-pyran rings.

A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)

Relaxin is a potent renal vasodilator in conscious rats. (1/7071)

The kidneys and other nonreproductive organs vasodilate during early gestation; however, the "pregnancy hormones" responsible for the profound vasodilation of the renal circulation during pregnancy are unknown. We hypothesized that the ovarian hormone relaxin (RLX) contributes. Therefore, we tested whether the administration of RLX elicits renal vasodilation and hyperfiltration in conscious adult, intact female rats. After several days of treatment with either purified porcine RLX or recombinant human RLX 2 (rhRLX), effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) increased by 20%-40%. Comparable renal vasodilation and hyperfiltration was also observed in ovariectomized rats, suggesting that estrogen and progesterone are unnecessary for the renal response to rhRLX. The nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl ester completely abrogated the increase in ERPF and GFR elicited by chronic administration of purified porcine RLX. In contrast, the renal vasoconstrictory response to angiotensin II was attenuated by the RLX treatment. Short-term infusion of purified porcine RLX to conscious rats over several hours failed to increase ERPF and GFR. Plasma osmolality was consistently reduced by the chronic administration of both RLX preparations. In conclusion, the renal and osmoregulatory effects of chronic RLX administration to conscious rats resemble the physiological changes of pregnancy in several respects: (a) marked increases in ERPF and GFR with a mediatory role for nitric oxide; (b) attenuation of the renal circulatory response to angiotensin II; and (c) reduction in plasma osmolality. (+info)

Loss of endothelium and receptor-mediated dilation in pial arterioles of rats fed a short-term high salt diet. (2/7071)

A high salt diet often is regarded as an accessory risk factor in hypertension, coincidental to the deleterious effect of high blood pressure on vasodilator function. The aim of this study was to determine whether short-term ingestion of a high salt diet per se impairs vasodilator function in the cerebral circulation independent of blood pressure changes. Adult Sprague-Dawley rats were fed a normal salt (0.8%) or high salt (4%) diet for 3 days. Mean arterial pressures were similar in the normal and high salt groups (123+/-2 and 125+/-2 mm Hg, respectively). Subsequently, the responses of the in situ pial arterioles to acetylcholine, iloprost, and sodium nitroprusside were determined in cranial windows using intravital videomicroscopy. Pial arterioles of rats fed normal and high salt diets showed similar resting diameters of 69+/-2 and 72+/-3 microm, respectively, but their reactivity patterns to vasodilator stimuli were markedly different. Arterioles of rats fed a normal salt diet dilated progressively up to 17+/-3% in response to the endothelium-dependent agent acetylcholine (10(-9) to 10(-6) mol/L) and dilated by 22+/-2% in response to the prostaglandin I2 receptor agonist iloprost (3x10(-11) mol/L). In contrast, pial arterioles of rats fed a high salt diet constricted by 4+/-3% and 8+/-2% in response to acetylcholine and iloprost, respectively. Sodium nitroprusside (10(-6) mol/L), a nitric oxide donor, dilated pial arterioles of rats fed low and high salt diets by a similar amount (19+/-3% and 16+/-2%, respectively), suggesting that signaling mechanisms for dilation distal to the vascular smooth muscle membrane were intact after high salt intake. These results provide the first evidence that the short-term ingestion of a high salt diet may severely impair the vasodilator function of the in situ cerebral microcirculation independent of blood pressure elevation. (+info)

Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. (3/7071)

We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates nitric oxide (NO) release in the rat kidney. To further investigate whether the NO-cGMP pathway is involved in the mechanisms of AM-induced vasodilation, we examined the effects of E-4021, a cGMP-specific phosphodiesterase inhibitor, on AM-induced vasorelaxation in aortic rings and perfused kidneys isolated from Wistar rats. We also measured NO release from the kidneys using a chemiluminescence assay. AM (10(-10) to 10(-7) mol/L) relaxed the aorta precontracted with phenylephrine in a dose-dependent manner. Denudation of endothelium (E) attenuated the vasodilatory action of AM (10(-7) mol/L AM: intact (E+) -25.7+/-5.2% versus denuded (E-) -7. 8+/-0.6%, P<0.05). On the other hand, pretreatment with 10(-8) mol/L E-4021 augmented AM-induced vasorelaxation in the intact aorta (-49. 0+/-7.9%, P<0.05) but not in the denuded one. E-4021 also enhanced acetylcholine (ACh)-induced vasorelaxation in the rat intact aorta (10(-7) mol/L ACh -36.6+/-8.4% versus 10(-8) mol/L E-4021+10(-7) mol/L ACh -62.7+/-3.1%, P<0.05). In perfused kidneys, AM-induced vasorelaxation was also augmented by preincubation with E-4021 (10(-9) mol/L AM -15.4+/-0.6% versus 10(-8) mol/L E-4021+10(-9) mol/L AM -23.6+/-1.2%, P<0.01). AM significantly increased NO release from rat kidneys (DeltaNO: +11.3+/-0.8 fmol. min-1. g-1 kidney at 10(-9) mol/L AM), which was not affected by E-4021. E-4021 enhanced ACh-induced vasorelaxation (10(-9) mol/L ACh -9.7+/-1.7% versus 10(-8) mol/L E-4021+10(-9) mol/L ACh -18.8+/-2.9%, P<0.01) but did not affect ACh-induced NO release from the kidneys. In the aorta and the kidney, 10(-4) mol/L of NG-nitro-L-arginine methyl ester, an NO synthase inhibitor, and 10(-5) mol/L of methylene blue, a guanylate cyclase inhibitor, reduced the vasodilatory effect of AM. These results suggest that the NO-cGMP pathway is involved in the mechanism of AM-induced vasorelaxation, at least in the rat aorta and kidney. (+info)

Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation. (4/7071)

BACKGROUND: The cardiovascular complications of Marfan syndrome arise due to alterations in the structural and functional properties of fibrillin, a constituent of vascular connective tissues. Fibrillin-containing microfibrils are closely associated with arterial endothelial cells, indicating a possible functional role for fibrillin in the endothelium. Plasma concentrations of endothelial cell products are elevated in Marfan subjects, which indirectly indicates endothelial dysfunction. This study directly assessed flow- and agonist-mediated endothelium-dependent brachial artery reactivity in Marfan subjects. METHODS AND RESULTS: In 20 Marfan and 20 control subjects, brachial artery diameter, blood flow, and blood pressure were measured by ultrasonic wall tracking, Doppler ultrasound, and photoplethysmography, respectively. Measurements were taken during hand hyperemia (a stimulus for endothelium-derived nitric oxide [NO] release in the upstream brachial artery) and after sublingual administration of the endothelium-independent vasodilator nitroglycerin. In 9 Marfan and 6 control subjects, the above parameters were also assessed during intra-arterial infusions of acetylcholine and bradykinin (agonists that stimulate NO production) and NG-monomethyl-L-arginine (L-NMMA, an inhibitor of NO production). Flow-mediated responses differed markedly between Marfan and control subjects (-1.6+/-3.5% versus 6. 50+/-4.1%, respectively; P<0.0001), whereas nitroglycerin produced similar vasodilation (14.2+/-5.7% versus 15.2+/-7.8%; P=NS). Agonist-induced vasodilation to incremental intra-arterial infusions of acetylcholine and bradykinin were not significantly different between Marfan and control subjects, and intra-arterial L-NMMA produced similar reductions in brachial artery diameter in both groups. CONCLUSIONS: These data demonstrate impaired flow-mediated but preserved agonist-mediated endothelium-dependent vasodilation in Marfan subjects and suggest preservation of basal NO release. Selective loss of flow-mediated dilation suggests a role for fibrillin in endothelial cell mechanotransduction. (+info)

Simultaneous assessment of effects of coronary vasodilators on the coronary blood flow and the myocardial contractility by using the blood-perfused canine papillary muscle. (5/7071)

Effects of 6 coronary vasodilators on the coronary blood flow and the contractile force of the ventricular muscle were examined simultaneously by injecting these drugs to the arterially blood-perfused canine papillary muscle preparation. All compounds produced a dose-dependent increase in blood flow rate, and relative potencies determined on the basis of doses producing a 100% increase in blood flow rate, ED100, were in the descending order : nifedipine greater than verapamil greater than diltiazem greater than dilazep greater than dipyridamole greater than carbochromen, and approximately 1 : 1/12 : 1/26 : 1/100 : 1/300 : 1/500. All drugs except for dipyridamole caused a dose-dependent decrease in the developed tension of the papillary muscle, although nifedipine and diltiazem in low doses produced a slight increase. Relative potencies determined on the basis of doses producing a 50% decrease in developed tension, ID50, were as follows: nifedipine (1), verapamil (1/13), diltiazem (1/40), dilazep (1/100), and carbochromen (1/270). Ratios of the ID50 to ED100 were as follows: diltiazem (5.2), nifedipine (3.5), verapamil (3.5), dilazep (2.5), and carbochromen (1.8). The higher the value the more predominant on the coronary vascular bed or the less depressant on the myocardial contractility were their actions. (+info)

Inhibition of endothelium-dependent hyperpolarization by endothelial prostanoids in guinea-pig coronary artery. (6/7071)

1. In smooth muscle of the circumflex coronary artery of guinea-pig, acetylcholine (ACh, 10(-6) M) produced an endothelium-dependent hyperpolarization consisting of two components. An initial component that occurs in the presence of ACh and a slow component that developed after ACh had been withdrawn. Each component of the hyperpolarization was accompanied by an increase in membrane conductance. 2. Indomethacin (5 x 10(-6) M) or diclofenac (10(-6) M), both inhibitors of cyclooxygenase, abolished only the slow hyperpolarization. The initial hyperpolarization was not inhibited by diclofenac nor by nitroarginine, an inhibitor of nitric oxide synthase. 3. Both components of the ACh-induced hyperpolarization were abolished in the presence of atropine (10(-6) M) or high-K solution ([K+]0 = 29.4 mM). 4. The interval between ACh-stimulation required to generate an initial hyperpolarization of reproducible amplitude was 20 min or greater, but it was reduced to less than 5 min after inhibiting cyclooxygenase activity. Conditioning stimulation of the artery with substance P (10(-7) M) also caused a long duration (about 20 min) inhibition of the ACh-response. 5. The amplitude of the hyperpolarization generated by Y-26763, a K+-channel opener, was reproducible within 10 min after withdrawal of ACh. 6. Exogenously applied prostacyclin (PGI2) hyperpolarized the membrane and reduced membrane resistance in concentrations over 2.8 x 10(-9)M. 7. At concentrations below threshold for hyperpolarization and when no alteration of membrane resistance occurred, PGI2 inhibited the initial component of the ACh-induced hyperpolarization. 8. It is concluded that endothelial prostanoids, possibly PGI2, have an inhibitory action on the release of endothelium-derived hyperpolarizing factor. (+info)

Acetylcholine-induced membrane potential changes in endothelial cells of rabbit aortic valve. (7/7071)

1. Using a microelectrode technique, acetylcholine (ACh)-induced membrane potential changes were characterized using various types of inhibitors of K+ and Cl- channels in rabbit aortic valve endothelial cells (RAVEC). 2. ACh produced transient then sustained membrane hyperpolarizations. Withdrawal of ACh evoked a transient depolarization. 3. High K+ blocked and low K+ potentiated the two ACh-induced hyperpolarizations. Charybdotoxin (ChTX) attenuated the ACh-induced transient and sustained hyperpolarizations; apamin inhibited only the sustained hyperpolarization. In the combined presence of ChTX and apamin, ACh produced a depolarization. 4. In Ca2+-free solution or in the presence of Co2+ or Ni2+, ACh produced a transient hyperpolarization followed by a depolarization. In BAPTA-AM-treated cells, ACh produced only a depolarization. 5. A low concentration of A23187 attenuated the ACh-induced transient, but not the sustained, hyperpolarization. In the presence of cyclopiazonic acid, the hyperpolarization induced by ACh was maintained after ACh removal; this maintained hyperpolarization was blocked by Co2+. 6. Both NPPB and hypertonic solution inhibited the membrane depolarization seen after ACh washout. Bumetanide also attenuated this depolarization. 7. It is concluded that in RAVEC, ACh produces a two-component hyperpolarization followed by a depolarization. It is suggested that ACh-induced Ca2+ release from the storage sites causes a transient hyperpolarization due to activation of ChTX-sensitive K+ channels and that ACh-activated Ca2+ influx causes a sustained hyperpolarization by activating both ChTX- and apamin-sensitive K+ channels. Both volume-sensitive Cl- channels and the Na+-K+-Cl- cotransporter probably contribute to the ACh-induced depolarization. (+info)

Enantioselective inhibition of the biotransformation and pharmacological actions of isoidide dinitrate by diphenyleneiodonium sulphate. (8/7071)

1. We have shown previously that the D- and L- enantiomers of isoidide dinitrate (D-IIDN and L-IIDN) exhibit a potency difference for relaxation and cyclic GMP accumulation in isolated rat aorta and that this is related to preferential biotransformation of the more potent enantiomer (D-IIDN). The objective of the current study was to examine the effect of the flavoprotein inhibitor, diphenyleneiodonium sulphate (DPI), on the enantioselectivity of IIDN action. 2. In isolated rat aortic strip preparations, exposure to 0.3 microM DPI resulted in a 3.6 fold increase in the EC50 value for D-IIDN-induced relaxation, but had no effect on L-IIDN-induced relaxation. 3. Incubation of aortic strips with 2 microM D- or L-IIDN for 5 min resulted in significantly more D-isoidide mononitrate formed (5.0 +/- 1.5 pmol mg protein(-1)) than L-isoidide mononitrate (2.1 +/- 0.7 pmol mg protein(-1)) and this difference was abolished by pretreatment of tissues with 0.3 microM DPI. DPI had no effect on glutathione S-transferase (GST) activity or GSH-dependent biotransformation of D- or L-IIDN in the 105,000 x g supernatant fraction of rat aorta. 4. Consistent with both the relaxation and biotransformation data, treatment of tissues with 0.3 microM DPI significantly inhibited D-IIDN-induced cyclic GMP accumulation, but had no effect on L-IIDN-induced cyclic GMP accumulation. 5. In the intact animal, 2 mg kg(-1) DPI significantly inhibited the pharmacokinetic and haemodynamic properties of D-IIDN, but had no effect L-IIDN. 6. These data suggest that the basis for the potency difference for relaxation by the two enantiomers is preferential biotransformation of D-IIDN to NO, by an enzyme that is inhibited by DPI. Given that DPI binds to and inhibits NADPH-cytochrome P450 reductase, the data are consistent with a role for the cytochromes P450-NADPH-cytochrome P450 reductase system in this enantioselective biotransformation process. (+info)

Rosendorff C (June 1993). "Beta-blocking agents with vasodilator activity". Journal of Hypertension Supplement. 11 (4): S37-40 ... Agents specifically labeled for migraine prophylaxis Timolol, propranolol Propranolol is the only agent indicated for the ... timolol Agents specifically labeled for cardiac arrhythmia Esmolol, sotalol, landiolol (Japan) Agents specifically labeled for ... depending on the concentration of the agent (beta blocker) and the concentration of the antagonized agent (usually an ...

https://en.wikipedia.org/wiki/Beta_blocker

... is a vasodilator and an anti-sickling agent. Alavi JB (May 1984). "Sickle cell anemia. Pathophysiology and treatment ...

https://en.wikipedia.org/wiki/Cetiedil

... is a precursor to bencyclane, a spasmolytic agent and vasodilator. Pimelic acid is produced by the oxidative ...

https://en.wikipedia.org/wiki/Cycloheptanone

... vasodilator agents Local: ACE inhibitors, ciclosporin, tacrolimus. Proximal convoluted tubule: Aminoglycoside antibiotics (e.g ...

https://en.wikipedia.org/wiki/Nephrotoxicity

... is a vasodilator which has been used as an antianginal agent. Morton IK, Hall JM (October 2012). "Etafenone". Concise ... Vasodilators, Aromatic ketones, Phenol ethers, Diethylamino compounds, All stub articles, Cardiovascular system drug stubs). ... Dictionary of Pharmacological Agents : Properties and Synonyms. New York: Springer. p. 115. ISBN 9789401059077. v t e (Articles ...

https://en.wikipedia.org/wiki/Etafenone

... an antiplatelet and vasodilator agent on gentamicin-induced nephrotoxicity in rats". Pharmacological Research. 44 (4): 321-8. ... Trapidil is a vasodilator and an antiplatelet drug. It also acts as an antagonist of platelet-derived growth factor. An analog ... Vasodilators, Phosphodiesterase inhibitors, Triazolopyrimidines, Diethylamino compounds, All stub articles, Cardiovascular ...

https://en.wikipedia.org/wiki/Trapidil

... (pyridylcarbinol) is a niacin derivative used as a hypolipidemic agent and as a vasodilator. It causes ... At least a couple of uses for this agent were discovered over the years: Eniclobrate Mepiroxol Nicofibrate Pantenicate ( ... Nicotinic acid is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes ... Topanicate, MG 28362) Norwood WF (1963). "Vasodilator Effects of Nicotinyl Tartrate (Roniacol Tartrate)". JAMA. 186: 1013. doi: ...

https://en.wikipedia.org/wiki/Nicotinyl_alcohol

Medications used include: diuretic agents, vasodilator agents, positive inotropes, ACE inhibitors, beta blockers, and ... The inotropic agent dobutamine is advised only in the short-term use of acutely decompensated heart failure, and has no other ... The combination of isosorbide dinitrate/hydralazine is the only vasodilator regimen, other than ACE inhibitors or angiotensin ...

https://en.wikipedia.org/wiki/Management_of_heart_failure

... quinazolinediones as possible peripheral vasodilators or antihypertensive agents". Journal of Medicinal Chemistry. 22 (12): ...

https://en.wikipedia.org/wiki/Pelanserin

... as a vasodilator and antiplatelet agent. It is classified as a prostacyclin analog. It has been studied for the treatment of ...

https://en.wikipedia.org/wiki/Beraprost

The medications most likely to result in palpitations include sympathomimetic agents, anticholinergic drugs, vasodilators and ...

https://en.wikipedia.org/wiki/Palpitations

Representative agents include bromoform and dibromodimethylhydantoin ("DBDMH"). Some herbicides, such as bromoxynil, contain ... Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the ... Alkyl bromine compounds are often alkylating agents and the brominated aromatic derivatives are implicated as hormone ... alkyl bromides are alkylating agents. Carbon-halogen bond strengths, or bond dissociation energies are of 115, 83.7, 72.1, and ...

https://en.wikipedia.org/wiki/Organobromine_compound

Like all halogens, it is thus one electron short of a full octet, and is hence a strong oxidising agent, reacting with many ... Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the ... It is also a weaker oxidising agent than chlorine, but a stronger one than iodine. Conversely, the bromide ion is a weaker ... A number of gaseous or highly volatile brominated halomethane compounds are non-toxic and make superior fire suppressant agents ...

https://en.wikipedia.org/wiki/Bromine

In the latter condition, inhaled NO is used as a diagnostic test of the response of the pulmonary arteries to vasodilators ( ... Today, NO is not only used in breath tests but also as a therapeutic agent for conditions such as pulmonary arterial ... agents that relax the blood vessels). eNO has also been associated with wheeze, rhinitis and nasal allergy in primary school ...

https://en.wikipedia.org/wiki/Exhaled_nitric_oxide

Commonly used agents include: Vasodilators acting as adenosine receptor agonists, such as adenosine itself, and dipyridamole ( ... Pharmacological stimulation from vasodilators such as dipyridamole or adenosine, or positive chronotropic agents such as ... Vasodilators are used to dilate coronary vessels, which causes increased blood velocity and flow rate in normal vessels and ... Pharmacologic agents such as adenosine, Lexiscan (regadenoson), or dipyridamole is generally used when a patient cannot achieve ...

https://en.wikipedia.org/wiki/Cardiac_stress_test

Parenteral agents are classified into beta-blockers, calcium channel blockers, systemic vasodilators, or other (fenoldopam, ... Patients should have their blood pressure slowly lowered over a period of minutes to hours with an antihypertensive agent. ... Several classes of anti hypertensive agents are recommended, with the choice depending on the cause of the hypertensive crisis ... Hydralazine and Sodium nitroprusside are systemic vasodilators, thereby reducing afterload, however can be found to have reflex ...

https://en.wikipedia.org/wiki/Hypertensive_emergency

Cyclandelate VP (nerve agent) Homosalate Bell, GD; Clegg, RJ; Ellis, WR; Middleton, B; White, DA (January 1984). "The effects ... 3,3,5-Trimethylcyclohexanol is a precursor to the vasodilator cyclandelate, the sunscreen component homosalate and the VP nerve ... Nerve agent precursors, All stub articles, Alcohol stubs). ... agent. It can be synthesized by hydrogenation of isophorone. It ...

https://en.wikipedia.org/wiki/3,3,5-Trimethylcyclohexanol

Inotropic Agents, Vasodilators, Nitrates, B-type Natriuretic Peptides, I(f) Inhibitors, ARNIs, Diuretics, Loop, Diuretics, ... The goal in using these pharmacologic agents is to decrease the afterload so that the left ventricle is somewhat spared. The ... Medical therapy of chronic aortic regurgitation that is stable and asymptomatic involves the use of vasodilators. Trials have ...

https://en.wikipedia.org/wiki/Aortic_regurgitation

... is a vasodilator agent affecting cardiovascular organs, such as heart, blood vessels and kidneys, with ...

https://en.wikipedia.org/wiki/Angiotensin_(1-7)

"1-Subst-phenyl-2-amino-ethanols useful as beta adrenergic agents peripheral vasodilators and hypotensive agents" Staff (5 ... Suloctidil was a sulfur-containing aminoalcohol that was brought to market in the early 1970s as a vasodilator by Continental ...

https://en.wikipedia.org/wiki/Suloctidil

... with the vasoactive pharmacological agents (vasoconstrictors or vasodilators and/or ACE Inhibitors and/or ARBs)(ACE = ... cardioactive or vasoactive agents. The measurement of CI and its derivatives allow clinicians to make timely patient assessment ... Pharmacological modulation of contractility is performed with cardioactive inotropic agents (positive or negative inotropes) ...

https://en.wikipedia.org/wiki/Impedance_cardiography

Inotropic agents, Vasodilators, Pyridazines, Phenol ethers, Dog medications). ... It is a calcium sensitizer and a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilator ...

https://en.wikipedia.org/wiki/Pimobendan

Inotropic agents, Vasodilators, Conjugated nitriles, 4-Pyridyl compounds, PDE3 inhibitors, 2-Pyridones). ... Milrinone, sold under the brand name Primacor, is a pulmonary vasodilator used in patients who have heart failure. It is a ... Shiao, Min-Jen; Shyu, Li-Ming; Chen, Chieh-Fu (1990). "Synthesis of Milrinone, a Cardiotonic Agent". HETEROCYCLES. 31 (3): 523 ...

https://en.wikipedia.org/wiki/Milrinone

Inotropic agents, 4-Pyridyl compounds, Vasodilators, PDE3 inhibitors, 2-Pyridones, Aromatic amines). ... Increases cardiac contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase ( ... as it functions as an arterial vasodilator and increases venous capacitance while decreasing venous return. There is a net ... "Relative Contribution of Inotropic and Vasodilator Effects of Amrinone- induced Hemodynamic improvement in congestive heart ...

https://en.wikipedia.org/wiki/Amrinone

Inotropic agents, Lactams, PDE3 inhibitors, Vasodilators). ... Quazinone (Dozonone) is a cardiotonic and vasodilator drug ... June 1985). "RO13-6438, a new inotrope-vasodilator: systemic and coronary hemodynamic effects in congestive heart failure". The ... Phosphodiesterase inhibitor David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN ... a novel positive inotropic agent with vasodilating properties". Journal of Cardiovascular Pharmacology. 6 (3): 511-9. doi: ...

https://en.wikipedia.org/wiki/Quazinone

Norepinephrine releasing agents, Stimulants, Sympathomimetics, Vasoconstrictors, Vasodilators). ... Whereas nitric oxide released in the corpus cavernosum is the major vasodilator contributing to the erectile process, ...

https://en.wikipedia.org/wiki/Yohimbine

Vasodilators, All stub articles, Antihypertensive agent stubs, Dermatologic drug stubs). ... and is the active form of this agent. Minoxidil acts as a prodrug of minoxidil sulfate. Minoxidil sulfate is formed from ... Antihypertensive agents, Hair loss medications, Human drug metabolites, Piperidines, Potassium channel openers, Sulfate esters ...

https://en.wikipedia.org/wiki/Minoxidil_sulfate

... antiretroviral agents, such as saquinavir with an isoquinolyl functional group, (shown below). vasodilators, a well-known ... antihypertension agents, such as quinapril and debrisoquine (all derived from 1,2,3,4-tetrahydroisoquinoline). ...

https://en.wikipedia.org/wiki/Isoquinoline

... is an antidepressant and coronary vasodilator of the phenothiazine class, invented in Russia and used as an anti- ... "Chapter 5: Antiarrhythmic and Antianginal Agents". In Clarke FH (ed.). Annual Reports in Medicinal Chemistry. Vol. 12. Elsevier ... anginal agent. It was found not to have antipsychotic activity, but was instead the first Russian tricyclic drug with ... Vasodilators, All stub articles, Cardiovascular system drug stubs). ...

https://en.wikipedia.org/wiki/Chloracyzine

Antihypertensive agents, Disulfiram-like drugs, Imidazolines, Phenols, Vasodilators, 4-Tolyl compounds). ... It is important to note that phentolamine is not a first-line agent for this indication. Phentolamine should only be given to ... Phentolamine is marketed in the dental field as a local anesthetic reversal agent. Branded as OraVerse, it is a phentolamine ...

https://en.wikipedia.org/wiki/Phentolamine

Metabolic control, which consists of metabolites and paracrine agents released from surrounding tissue that act on the blood ... More specifically it is regulated by adenosine, a local vasodilator produced by neighboring cells. Therefore, the heart is ...

https://en.wikipedia.org/wiki/Local_blood_flow_regulation

"The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects ... of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents". Cell ...

https://en.wikipedia.org/wiki/GPR55

Agents. 31 (3): 189-92. doi:10.1016/j.ijantimicag.2007.11.010. PMID 18248798. Abraham EP (1987). "Cephalosporins 1945-1986". ... In 1952 researchers at Ciba discovered the first orally available vasodilator, hydralazine. A major shortcoming of hydralazine ... Approximately 400 tons of these agents are manufactured each year; this is enough to put approximately 9,000,000 people to ... Lv J, Perkovic V, Foote CV, Craig ME, Craig JC, Strippoli GF (2012). "Antihypertensive agents for preventing diabetic kidney ...

https://en.wikipedia.org/wiki/Pharmaceutical_industry

The anti-migraine action is thought to be due to its action as a vasodilator, but it also has some anxiolytic effects and ... "Mechanisms of blockade by the novel migraine prophylactic agent, dotarizine, of various brain and peripheral vessel ...

https://en.wikipedia.org/wiki/Dotarizine

The inability of vasodilators and antithrombotic protectants to correct PAH suggests that the progression of PAH is dependent ... Evidence has been forwarded that environmental stimuli are important agents in the alteration of epigenes. Ironically, ... Current treatments for PAH have attempted to correct symptoms of PAH with vasodilators and antithrombotic protectors, but ...

https://en.wikipedia.org/wiki/Transgenerational_epigenetic_inheritance

... is a vasodilator that acts as an adenosine reuptake inhibitor. It is used for the treatment of cardiopathy and renal ... an antiplatelet agent, inhibits tissue factor expression in endothelial cells and monocytes". Blood. 90 (6): 2345-56. doi: ... v t e (Chemical pages without DrugBank identifier, Drugs with no legal status, Vasodilators, Pyrogallol ethers, Benzoate esters ...

https://en.wikipedia.org/wiki/Dilazep

The differential vasoconstriction of these fetal vessels compared to the vasodilator response of other vessels suggests that ... Stewart JM (2003). "Bradykinin antagonists as anti-cancer agents". Current Pharmaceutical Design. 9 (25): 2036-42. doi:10.2174/ ... Bradykinin is a potent endothelium-dependent vasodilator and mild diuretic, which may cause a lowering of the blood pressure. ... and bradykinin antagonists have been investigated as anti-cancer agents. Bradykinin has been proposed as an explanation for ...

https://en.wikipedia.org/wiki/Bradykinin

Recent research has suggested that the locally produced vasodilators may be acting in a redundant manner, in which the ... Hyperaemia is likely mediated by the increased synthesis and/or release of vasodilatory agents during periods of heightened ... Some of the putative vasodilatory agents (associated with metabolism) include, but are not limited to: carbon dioxide (CO2), ... It is thought that vasodilators (released from active muscle fibers) can stimulate a local capillary endothelial cells which, ...

https://en.wikipedia.org/wiki/Hyperaemia

They are not thought to be good as first line treatment because there are other more selective agents, although they can be ... Prazosin was synthesized in 1974 when Constantin and Hess were trying to discover a vasodilator which had a minimal effect on ... Alpha-1 blockers (also called alpha-adrenergic blocking agents or alpha-1 antagonists) constitute a variety of drugs that block ... Because these medications may cause orthostatic hypotension, as well as low blood pressure in general, these agents may ...

https://en.wikipedia.org/wiki/Alpha-1_blocker

PG-X, which later would become known as prostacyclin, was 30 times more potent than any other known anti-aggregatory agent.[ ... Since treprostinil is a vasodilator, its antihypertensive effect may be compounded by other medications that affect the blood ... is a vasodilator that is used for the treatment of pulmonary arterial hypertension. Treprostinil is a synthetic analog of ... pressure, including calcium channel blockers, diuretics, and other vasodilating agents. Because of treprostinil's inhibiting ...

https://en.wikipedia.org/wiki/Treprostinil

... is a vasodilator beta blocker also classified as a mixed receptor blocker as it blocks both alpha and beta receptors ... Antihypertensive agent stubs). ...

https://en.wikipedia.org/wiki/Medroxalol

Adjuvant agents are typically administered in addition to sedative-hypnotic agents to supplement the induction of TIVA. ... vasodilators, which need to be continuously titrated in the operating room. Smart pumps are advantageous since they administer ... Unlike inhaled anesthetic agents, intravenous agents do not have an indicative end-tidal anesthetic concentration (ETAC) for ... The dose of sedative-hypnotic agents should be reduced due to the synergistic effects when combined with adjuvant agents. ...

https://en.wikipedia.org/wiki/Total_intravenous_anaesthesia

NGF has not been found in human saliva; however, researchers find human saliva contains such antibacterial agents as secretory ... which is a vasodilator; it is secreted by the acinar cells of all three major salivary glands Antimicrobial enzymes that kill ... antimicrobial agents (such as secretory IgA, and lysozymes). The enzymes found in saliva are essential in beginning the process ... chemical and bacterial agents. The production of saliva is stimulated both by the sympathetic nervous system and the ...

https://en.wikipedia.org/wiki/Saliva

... vasodilator agents MeSH D27.505.954.411.918.500 - endothelium-dependent relaxing factors MeSH D27.505.954.427 - central nervous ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D27)

... bis-glycidyl ether can be crosslinked to a thermosetting epoxy resins with suitable curing agents, such as ... for the treatment of angina pectoris due to its vasodilator effect. Esterification of isosorbide with fatty acids gives access ...

https://en.wikipedia.org/wiki/Isosorbide

Vasodilators, Substituted amphetamines, Calcium channel blockers, Norepinephrine-dopamine releasing agents). ... Prenylamine (Segontin) is a calcium channel blocker of the amphetamine chemical class that was used as a vasodilator in the ... This depletion mechanism is similar to that of reserpine because both agents target the same site on the storage granule; ...

https://en.wikipedia.org/wiki/Prenylamine

... is believed to be an anti-inflammatory agent at the A2A receptor. Topical treatment of adenosine to foot wounds in ... Morgan JM, McCormack DG, Griffiths MJ, Morgan CJ, Barnes PJ, Evans TW (September 1991). "Adenosine as a vasodilator in primary ... Because of the effects of adenosine on AV node-dependent SVTs, adenosine is considered a class V antiarrhythmic agent. When ... Antiarrhythmic agents, Chemical substances for emergency medicine, Drugs acting on the cardiovascular system, Ghrelin receptor ...

https://en.wikipedia.org/wiki/Adenosine

Hepatocyte growth factor (HGF) is a mitogen and insulin tropic agent for the β cell. Inadequate β-cell mass can lead to insulin ... At the cellular level, the balance between vasodilator (Nitric oxide) and vasoconstrictor (ET-1) actions determines the ... That is why nesfatin-1 has drawn attention as a new therapeutic agent, especially for the treatment of obesity and diabetes ... FGF21 can function as a crucial regulator mediating beneficial metabolic effects of therapeutic agents such as metformin, ...

https://en.wikipedia.org/wiki/Biomarkers_of_diabetes

... a vasodilator and explosive, the trinitrate derivative pentrinitrol (Petrin), the tetraacetate normosterol (PAG), and the ... polymer cross-linking agent pentaerythritol tetraacrylate. Pentaerythritol is used as a fire retardant, such as in plastics and ...

https://en.wikipedia.org/wiki/Pentaerythritol

The catheter is moved through the vein to the enlarged pelvic veins, allowing the introduction of embolic agents, which are ... With a catheter in place, provocative maneuvers can be performed such as breath holds or instillation of vasodilators, to ... Vaidya, S.; Tozer, K. R.; Chen, J. (2008). "An Overview of Embolic Agents". Seminars in Interventional Radiology. 25 (3): 204- ... Ablative Chemoembolization: Combined injection of chemotherapy and embolic agents into the arterial blood supply of a tumor, ...

https://en.wikipedia.org/wiki/Interventional_radiology

ISBN 978-3-11-015714-7. Nagasaka, A.; Hidaka, H. (1976). "Effect of Antithyroid Agents 6-Propyl-2-Thiouracil and l-Methyl-2- ... Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been ...

https://en.wikipedia.org/wiki/2-Thiouracil

These agents act to uncouple DP1 from its G proteins and to internalize in a process that limits the DP1's cell-activation life ... in humans in commonly treated with specific pulmonary artery vasodilators that increase survival such as the prostacyclin I2 ( ...

https://en.wikipedia.org/wiki/Prostaglandin_DP1_receptor

... (A-53,986, KB-944) is a vasodilator acting as a calcium channel blocker which was under development for the treatment ... Ibrolipim Calcium channel blocker David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC ... Morita T, Yoshino K, Kanazawa T, Ito K, Nose T (1982). "Vasodilator action of KB-944, a new calcium antagonist". Arzneimittel- ... Morita T, Kanazawa T, Ito K, Nose T (1982). "Vasodilator mechanism of KB-944, a new calcium antagonist". Arzneimittel-Forschung ...

https://en.wikipedia.org/wiki/Fostedil

JavaScript is disabled for your browser. Some features of this site may not work without it ...

https://apps.who.int/iris/browse?authority=Vasodilator+Agents&type=mesh

JavaScript is disabled for your browser. Some features of this site may not work without it ...

https://extranet.who.int/iris/restricted/browse?authority=Vasodilator+Agents&type=mesh

Antiparasitic agents. Class Summary. For reduction in parasitemia and improvement of clinical signs and symptoms of Chagas ... The propensity of both of these agents to induce chromosomal aberrations requires further study. ...

https://www.medscape.com/answers/174783-81084/what-is-the-role-of-medications-in-the-treatment-of-esophageal-motility-disorders

It is a potent and rapid-acting agent with peak action at 60 minutes and a 6- to 8-hour duration of action. ... Fenoldopam is a selective dopamine-receptor agonist that acts as a rapid-acting vasodilator. It is 6 times more potent than ...

https://emedicine.medscape.com/article/243492-medication

... and who developed severe pulmonary edema in response to pulmonary vasodilators. ... presenting as pulmonary hypertensive vascular disease and fatal pulmonary edema in response to pulmonary vasodilator therapy J ... Vasodilator Agents ...

https://pubmed.ncbi.nlm.nih.gov/22658788/?dopt=Abstract

Nitroglycerin, an organic nitrate, is available in many forms as a vasodilator. Nitroglycerin is used in the treatement of ...

https://pharmacycode.com/Nitro-Pflaster.html

Inotropic Agents. Class Summary. These agents augment coronary and cerebral blood flow during the low-flow state associated ... Antiplatelet Agents, Cardiovascular. Class Summary. Agents that irreversibly inhibit platelet aggregation may improve morbidity ... Vasodilators relax vascular smooth muscle and reduce the SVR, allowing for improved forward flow, which improves cardiac output ... This agent causes relaxation of vascular smooth muscle by stimulating intracellular cyclic guanosine monophosphate production. ...

https://www.staging.medscape.com/answers/152191-60581/which-medications-in-the-drug-class-antiplatelet-agents-cardiovascular-are-used-in-the-treatment-of-cardiogenic-shock

Protective Agents. Calcium Channel Blockers. Membrane Transport Modulators. Calcium-Regulating Hormones and Agents. Vasodilator ... Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of Pharmacological Action. Physiological Effects of Drugs. ...

https://clinicaltrials.gov/show/NCT02717507

Agents Having Vasodilator Activity : Data on the effect of concomitant use of other vasodilators in patients receiving ... Therefore, agents affecting sympathetic activity (e.g., ganglionic blocking agents or adrenergic neuron blocking agents) should ... additional antihypertensive agents (diuretics, beta blockers, centrally acting agents or vasodilators) were added as needed for ... Other antihypertensives such as diuretics, beta blockers, centrally acting agents or vasodilators may be used in conjuction ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=af396e2c-198a-4082-a0a1-d4e673d32fec

Pharmacological Actions : Vasodilator Agents. [+] Supplementation of diets with the black rice pigment fraction attenuates ...

https://greenmedinfo.com/disease/arterial-plaque

An agent that selectively binds to and activates adrenergic receptors.. vasodilator agent A drug used to cause dilation of the ... vasoconstrictor agent Drug used to cause constriction of the blood vessels.. mydriatic agent Agent that dilates the pupil. Used ... R)-adrenaline (CHEBI:28918) has role vasodilator agent (CHEBI:35620) (R)-adrenaline (CHEBI:28918) is a adrenaline (CHEBI:33568 ... R)-adrenaline (CHEBI:28918) has role mydriatic agent (CHEBI:50513) (R)-adrenaline (CHEBI:28918) has role sympathomimetic agent ...

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28918

Other AHMs include selective aldosterone receptor inhibitors, peripheral vasodilators, alpha blockers, and centrally acting ... and centrally acting agents. ...

https://www.cdc.gov/mmwr/volumes/65/wr/mm6536e1.htm

A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. ... This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may ... calcium channel blocker used as a coronary vasodilator in the treatment of coronary insufficiency and angina. ... A dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions ...

https://fpnotebook.com/CV/Pharm/Nfdpn.htm

Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting enzyme inhibition in patients with heart ...

https://www.research.ed.ac.uk/en/persons/david-webb-2/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=type&descending=false

The augmentation of coronary flow in response to these agents was correlated with age, plasma levels of total, low-density ... The augmentation of coronary flow in response to these agents was correlated with age, plasma levels of total, low-density ... The augmentation of coronary flow in response to these agents was correlated with age, plasma levels of total, low-density ... The augmentation of coronary flow in response to these agents was correlated with age, plasma levels of total, low-density ...

https://jhu.pure.elsevier.com/en/publications/effects-of-aging-on-the-modulation-of-coronary-flow-by-endotheliu-4

NO is a vasodilator agent known to help improve the body with various tangible benefits for those unaware. For example, it ... A: From a scientific perspective, one would refer to Nitric Oxide as a vasodilator. Nitric Oxide is a compound that can help ... The active agents in the mix can help prolong ones ejaculation, thus allowing for heightened pleasure. ... Manufacturers claim that these make male enhancement pills have active agents to provide users with a range of benefits like ...

https://www.peninsuladailynews.com/national-marketplace/buy-the-best-male-enhancement-pills-that-work-for-real-results/

It has vasodilator properties, antiplatelet agents, prevents bleeding and strengthens the capillaries. ...

https://www.botanical-online.com/en/medicinal-plants/blueberry-properties

Vasodilator Agents Medicine & Life Sciences 25% * Vasodilation Medicine & Life Sciences 24% View full fingerprint ... is associated with altered vasodilator responses to β2-agonists, which may modulate the pressor response to endogenous ... is associated with altered vasodilator responses to β2-agonists, which may modulate the pressor response to endogenous ... is associated with altered vasodilator responses to β2-agonists, which may modulate the pressor response to endogenous ...

https://mayoclinic.pure.elsevier.com/en/publications/the-arg16gly-%CE%B2sub2sub-adrenergic-receptor-polymorphism-is-associa

Vasodilator Agent Medicine and Dentistry 42% * Exome Sequencing Medicine and Dentistry 21% ... Objectives: We sought to identify gene variants (GVs) underlying IPAH and determine whether GVs differ in vasodilator- ... Objectives: We sought to identify gene variants (GVs) underlying IPAH and determine whether GVs differ in vasodilator- ... Objectives: We sought to identify gene variants (GVs) underlying IPAH and determine whether GVs differ in vasodilator- ...

https://www.scholars.northwestern.edu/en/publications/critical-genomic-networks-and-vasoreactive-variants-in-idiopathic

Milrinone is a positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase activity in ... EV71 was found to be the primary causative agent of HFMD epidemics from 2009 to 2013 (Fig. 1 & Table 1). ... Epidemiological and genetic analysis concerning the non-enterovirus 71 and non-coxsackievirus A16 causative agents related to ...

https://www.researchsquare.com/article/rs-842/v2

Hemodynamic and clinical evaluation of piroximone, a new inotrope-vasodilator agent, in severe congestive heart failure.. ... Hot spot imaging agents for acute myocardial infarction.. Journal of nuclear medicine : official publication, Society of ... Current methods of pharmacologic stress testing and the potential advantages of new agents.. Journal of nuclear medicine ... His research involves recent applications of the scintigraphic imaging agent indicates its ability to map the regional density ...

https://chc.ucsf.edu/people/elias-botvinick-md

Co-administration with Other Vasodilators or Negative Chronotropic Agents: Use with caution due to additive pharmacodynamic ... In clinical trials where other vasodilators or negative chronotropic agents were co-administered with dexmedetomidine ... The intravenous administration of anticholinergic agents (e.g., glycopyrrolate, atropine) should be considered to modify vagal ... Nonetheless, caution should be used when such agents are administered concomitantly with dexmedetomidine hydrochloride in 0.9% ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aea9a3ad-c244-42be-9cd3-5df83fe2b522&audience=consumer

Unstable angina or acute phase myocardial infarction, with or without vasodilator agents 12. Diabetic or potentially diabetic ...

http://www.druglib.com/trial/65/NCT02018965.html

Hypoxia is an inducer of vasodilator agents in peritoneal macrophages of cirrhotic patients. Cejudo-Martín, P., Morales-Ruiz, M ... Only VEGF and ADM were constitutively secreted, and hypoxia further stimulated the release of these vasodilator peptides [1]. ... shares limited sequence homology with the sensory nerve-derived vasodilator, calcitonin gene-related peptide (CGRP) [20]. ...

https://www.wikigenes.org/e/gene/e/133.html

The enhanced vasodilator activity of a local anesthetic agent results in shorter duration of action because of faster ... All local anesthetics are vasodilators (except cocaine) where the vasodilator activity leads to faster absorption and thus ... For example, a short-acting agent (e.g., mepivacaine) will be useful for creation of excellent intraoperative conditions with ... Covino BG, Pharmacology of local-anesthetic agents. British Journal of Anaesthesia. 1986;. 58. (7):701-716. DOI: 10.1093/bja/ ...

https://www.intechopen.com/chapters/56301

Vasodilator Agents Medicine & Life Sciences 81% * Endothelial Cells Medicine & Life Sciences 59% ... Tsai, T. Y., Leong, I. L., Shiao, L. R., Wong, K. L., Shao, L., Chan, P., & Leung, Y. M. (2020). Tannic acid, a vasodilator ... Tannic acid, a vasodilator present in wines and beverages, stimulates Ca2+ influx via TRP channels in bEND.3 endothelial cells. ... Tannic acid, a vasodilator present in wines and beverages, stimulates Ca2+ influx via TRP channels in bEND.3 endothelial cells ...

https://tmu.pure.elsevier.com/zh/publications/tannic-acid-a-vasodilator-present-in-wines-and-beverages-stimulat

Thallium-201 (201Tl) myocardial scintigraphy with dipyridamole (DPM) as a vasodilator agent has been utilized to identify ... New contrast agents that compartmentalize to the intravascular space, such as gadofosveset trisodium, may be the answer to this ... Gadolinium-based contrast agents have been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic ... 46] Further studies are required before this agent can be considered for approval by the FDA. ...

https://emedicine.medscape.com/article/417244-overview

Topical application of vasodilator agents such as nitric oxide and the L-type voltage-dependent Ca2+ channel blocker nimodipine ... and the impact of SAH on the relative balance of vasoconstrictor and vasodilator influences. Development of agents and ... J. P. Dreier, G. Petzold, K. Tille et al., "Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators ... followed by a vasodilator tone during repolarization, and then a second vasoconstrictive phase that can last up to an hour [53 ...

https://www.hindawi.com/journals/srt/2013/819340/

PGE1alpha ‐ A potent vasodilator agent that increases peripheral blood flow.…. *Life, Germ-Free ‐ Animals not ... Sulfate, Sodium Tetradecyl ‐ An anionic surface-active agent used for its wetting properties… ...

https://clustermed.info/dictionary/s/sino-atrial-nodes.html

Pharmacological agents, including vasodilators, inotropes and vasopressors, are frequently used in the critical care setting ... Conventional inotropic agents appear to be useful in restoring hemodynamic parameters and improving peripheral organ perfusion ...

https://www.pulsus.com/author/suumlleyman-karakoyun-952

A potent vasodilator agent with calcium antagonistic action. (fpnotebook.com)
A potent vasodilator agent that increases peripheral blood flow. (clustermed.info)

A coronary vasodilator agent. (bvsalud.org)

In an effort to reverse these hemodynamic changes, vasodilators and diuretics have been tested as prophylactic drugs. (elsevier.com)

However, these non-selective adenosine agonist stress agents act on other adenosine receptor subtypes such as A 1 , A 2B , and A 3 causing frequent side-effects like AV block, peripheral vasodilation, and bronchoconstriction. (scirp.org)
Hence, adenosine 2A selective pharmacological stress agent could provide adequate coronary vasodilation for SPECT and lessen/ avoid other undesirable side-effects. (scirp.org)

Formerly known as amrinone, inamrinone is a phosphodiesterase inhibitor with positive inotropic and vasodilator activity. (medscape.com)
Pimobendan is a mixed action drug, with inotropic and vasodilator proprieties, widely used to treat such dogs. (ufrgs.br)

Most currently available treatment utilise anticoagulants as well as vasodilator drugs that only attenuate the vasoconstrictive component of the disease. (utmb.edu)
Along with biophysical modalities, agents that have been used for nonoperative management include bisphosphonates, anticoagulants, vasodilators, and statins. (medscape.com)

Dopamine and dobutamine are the drugs of choice to improve cardiac contractility, with dopamine the preferred agent in patients with hypotension. (medscape.com)
Vasodilators relax vascular smooth muscle and reduce the SVR, allowing for improved forward flow, which improves cardiac output. (medscape.com)
Pharmacological agents, including vasodilators, inotropes and vasopressors, are frequently used in the critical care setting for the management of unstable cardiac patients. (pulsus.com)
These results show that the cardioprotective effects of BMS-191095 are dissociated from peripheral vasodilator and cardiac sarcolemmal K ATP activation. (aspetjournals.org)
Coronary vasodilator and cardiac effects of (-) and (+) verapamil were investigated in two kinds of canine heart preparations. (elsevier.com)

We describe 5 infants diagnosed with nonketotic hyperglycinemia, in whom pulmonary hypertensive vascular disease was the main presenting feature, and who developed severe pulmonary edema in response to pulmonary vasodilators. (nih.gov)
Rodríguez-Pérez Á, Bos L, Podzamczer I, López Meseguer M, Mayos-Pérez M, Leta R. Right Ventricular Postsystolic Strain Curve Morphology before and after Vasodilator Treatment in Idiopathic Pulmonary Arterial Hypertension. (gencat.cat)
Treatment with vasodilators is often ineffective in patients with longstanding pulmonary hypertension in which structural changes contribute significantly to the pulmonary hypertension, blood flow obstruction and right heart failure. (utmb.edu)
Agents inflicting oxidative stress include many local chapters in large doses, pulmonary disease is present, digoxin also can be caused by leukemic cell infiltration of the cell that it is common in males, cleft palate nation of recurrence if future group a streptococci, hib, or another aminoglycoside are preferred. (aaan.org)

Conventional inotropic agents appear to be useful in restoring hemodynamic parameters and improving peripheral organ perfusion, but they can increase short-term and long-term mortality in these patients. (pulsus.com)
Used as peripheral vasodilators. (mims.com)

Results: Grp 1 and Grp 2 were comparable in hemodynamic parameters with increase in HR and decrease in systolic and diastolic BP with administration of adenosine and REG stress agents. (scirp.org)
Adenosine and dipyridamole are most widely used and well known pharmacological vasodilator stress agents for patients with baseline ECG abnormality. (scirp.org)

This, in turn, inhibits the conversion of arachidonic acid to prostaglandin 12 (a potent vasodilator and inhibitor of platelet activation) and thromboxane A2 (a potent vasoconstrictor and platelet aggregate). (medscape.com)

Fenoldopam is a selective dopamine-receptor agonist that acts as a rapid-acting vasodilator. (medscape.com)
The present data demonstrate agmatine, as a CDS and agonist for imidazoline (I) receptors, possesses marked systemic vasodilator activity in the rat. (uthscsa.edu)

Objectives: We sought to identify gene variants (GVs) underlying IPAH and determine whether GVs differ in vasodilator-responsive IPAH(VR-PAH)versusvasodilator-nonresponsiveIPAH(VN-PAH). (northwestern.edu)

Systemic hypertension is a potential complication of certain cancer therapies, including vascular endothelial growth factor (VEGF) signaling pathway inhibitors, alkylating agents, taxanes, proteasome inhibitors, pyrimidine analogs, and vinca alkaloids. (acc.org)

Vasodilators are substances that expand veins and increment course. (busineshope.com)

It is also used as a vasodilator, intestinal relaxant, bronchodilator, and an antidote to cyanide poisoning, and hydrogen sulfide poisoning. (sodium-nitrite.com)

Regadenoson (REG) was approved as a pharmacological stress agent for SPECT by the Food and Drug Administration in April 2008 [6]. (scirp.org)

Purpose: Regadenoson (REG) is currently becoming the stress agent of choice in patients undergoing pharmacologic single photon emission computed tomography (SPECT). (scirp.org)

REG is rapidly becoming the most widely used vasodilator agent in patients undergoing SPECT. (scirp.org)
Widely used in cosmetics as an anti-aging agent, it is beneficial to all areas of the skin, everything from the face and beauty routines to delicate baby bottoms when their diapers have rubbed them raw. (promiselifeblog.com)

In animal studies, captopril did not alter the pressor responses to a number of other agents, including angiotensin II and norepinephrine, indicating specificity of action. (nih.gov)
Background: Despite the rapidly increasing age of the population of women with ischemic heart disease and known age- and lipid-related histological arterial changes that may influence coronary vasoreactivity, the influences of age and lipid levels on coronary vasomotor responses to commonly used endothelium-independent vasodilators have not been reported. (elsevier.com)
A polymorphism in the gene encoding the β 2 -adrenergic receptor (arginine or glycine at amino acid position 16) is associated with altered vasodilator responses to β 2 -agonists, which may modulate the pressor response to endogenous catecholamines during stress. (elsevier.com)
These data suggest that 14 days of simulated microgravity exposure, using the HDT bed rest model, reduces cutaneous vasodilator and sweating capacity, whereas aerobic exercise training during HDT bed rest preserves these responses. (uky.edu)

Breast-fed infants of mothers taking antihypertensive agents must be intently monitored for potential antagonistic effects. (elgouna.com)

His research involves recent applications of the scintigraphic imaging agent indicates its ability to map the regional density of sympathetic nerves and support the hypothesis that an altered balance in the relationship of perfusion and innervation can increase vulnerability to life threatening arrhythmias. (ucsf.edu)

and aerosolised prostacyclin analogues and inhaled nitric oxide but all three classes of vasodilators have disadvantages and limitations. (utmb.edu)
Suplimentele nutritive cu oxid nitric (monoxid de azot) permit o crestere dramatica a masei musculare, acesta fiind un puternic agent vasodilator. (culturism.ro)
Although the endothelium co-generates both nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF), the relative contribution from each vasodilator is not clear. (ox.ac.uk)

Amlodipine is a pure vasodilator drug used as an anti-hypertensive agent, with no inotropic effects. (ufrgs.br)

Co-administration with Other Vasodilators or Negative Chronotropic Agents: Use with caution due to additive pharmacodynamic effects. (nih.gov)
May potentiate effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension. (mims.com)
The effects of microgravity exposure on cutaneous vasodilator capacity and on sweat gland function are unknown. (uky.edu)
It is a natural stimulant without the threatening side effects (palpitations, hyper-activity or rise in blood pressure) of most other stimulating agents. (fasting.ws)

Agents like BMS-191095 may owe their cardioprotective selectivity to selective mitochondrial K ATP activation. (aspetjournals.org)

An agent that selectively binds to and activates adrenergic receptors. (ebi.ac.uk)

The major objective of treating persistent hypertension in being pregnant is to scale back maternal danger, however the selection of antihypertensive agent(s) is largely driven by the safety of the fetus. (elgouna.com)
Selection of antihypertensive agents and route of administration is dependent upon anticipated timing of delivery. (elgouna.com)

Calcitonin gene related peptide: vasodilator in ovine hepatic and renal vasculature. (austin.org.au)

A dihydropyridine calcium channel blocking agent. (fpnotebook.com)
calcium channel blocker used as a coronary vasodilator in the treatment of coronary insufficiency and angina. (fpnotebook.com)

It is a potent and rapid-acting agent with peak action at 60 minutes and a 6- to 8-hour duration of action. (medscape.com)

Vasodilators decrease preload and/or afterload. (medscape.com)
This is based on risk factor modification, associated to the use of vasodilators (pentoxiphilin, cilostazole) to prevent or decrease intermittent claudication and of anti-platelet agents (aspirin, clopidogrel) to prevent the risk of thrombotic complications. (bvsalud.org)

These agents augment coronary and cerebral blood flow during the low-flow state associated with cardiogenic shock. (medscape.com)

This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (fpnotebook.com)

These agents are also indicated to reduce the risk of hospitalization for heart failure in patients with type 2 diabetes mellitus who with either established cardiovascular disease or multiple cardiovascular risk factors. (medscape.com)

Watermelon produces cancer prevention agents. (busineshope.com)

BMS-180448), which retain the cardioprotective activity of agents such as cromakalim while being significantly less potent as vasodilators. (aspetjournals.org)

Studies comparing the therapeutic activity of 1912 TABLE 206-1 -- In-vitro activity of selected agents used to treat influenza. (qrforex.com)

These agents have moderate afterload reduction properties and cause slight preload reduction. (medscape.com)

Commonly found in richly-colored plants and vegetable matter, flavonoids, and by extension, flavanols, are potent antioxidants, anti-inflammatory agents and immune-system enhancing phytonutrients. (supplementpolice.com)
Cancer prevention agents are additionally phytonutrients. (busineshope.com)

It is found in nerves in the vasculature and is known from in vitro studies to be a potent vasodilator. (austin.org.au)

vasodilators and aldosterone antagonists in the management of chronic heart failure. (bvsalud.org)

Anatomy9

Organisms1

Diseases2

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes13

Relaxin is a potent renal vasodilator in conscious rats. (1/7071)

Loss of endothelium and receptor-mediated dilation in pial arterioles of rats fed a short-term high salt diet. (2/7071)

Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. (3/7071)

Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation. (4/7071)

Simultaneous assessment of effects of coronary vasodilators on the coronary blood flow and the myocardial contractility by using the blood-perfused canine papillary muscle. (5/7071)

Inhibition of endothelium-dependent hyperpolarization by endothelial prostanoids in guinea-pig coronary artery. (6/7071)

Acetylcholine-induced membrane potential changes in endothelial cells of rabbit aortic valve. (7/7071)

Enantioselective inhibition of the biotransformation and pharmacological actions of isoidide dinitrate by diphenyleneiodonium sulphate. (8/7071)

Vasodilator Agents

Papaverine

Nitroprusside

Vasodilation

Acetylcholine

Vascular Resistance

Nitric Oxide

Regional Blood Flow

Nitroglycerin

Forearm

Endothelium, Vascular

Hydralazine

Bradykinin

Vasoconstriction

Hemodynamics

Blood Pressure

NG-Nitroarginine Methyl Ester

Epoprostenol

Calcitonin Gene-Related Peptide

Vasoconstrictor Agents

Mesenteric Arteries

Hyperemia

Coronary Circulation

Pulmonary Circulation

Adenosine

Hypertension, Pulmonary

Coronary Vessels

Vasomotor System

Splanchnic Circulation

omega-N-Methylarginine

Nitric Oxide Synthase

Dose-Response Relationship, Drug

Dogs

Arginine

Arterioles

Endothelium-Dependent Relaxing Factors

Plethysmography

Muscle, Smooth, Vascular

Adrenomedullin

Renal Circulation

Cromakalim

Indomethacin

Nitroarginine

Dipyridamole

Minoxidil

Pulmonary Artery

Isosorbide Dinitrate

Arteries

Biological Factors

Microcirculation

Enzyme Inhibitors

Prostaglandins

Heart Rate

Benzopyrans

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

Relaxin is a potent renal vasodilator in conscious rats. (1/7071)

Loss of endothelium and receptor-mediated dilation in pial arterioles of rats fed a short-term high salt diet. (2/7071)

Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. (3/7071)

Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation. (4/7071)

Simultaneous assessment of effects of coronary vasodilators on the coronary blood flow and the myocardial contractility by using the blood-perfused canine papillary muscle. (5/7071)

Inhibition of endothelium-dependent hyperpolarization by endothelial prostanoids in guinea-pig coronary artery. (6/7071)

Acetylcholine-induced membrane potential changes in endothelial cells of rabbit aortic valve. (7/7071)

Enantioselective inhibition of the biotransformation and pharmacological actions of isoidide dinitrate by diphenyleneiodonium sulphate. (8/7071)

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