Vasodilation. Medical search

The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.

Drugs used to cause dilation of the blood vessels.

Part of the arm in humans and primates extending from the ELBOW to the WRIST.

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

The smallest divisions of the arteries located between the muscular arteries and the capillaries.

A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.

Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.

The flow of BLOOD through or around an organ or region of the body.

A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.

The continuation of the axillary artery; it branches into the radial and ulnar arteries.

The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.

A competitive inhibitor of nitric oxide synthetase.

The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).

A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.

An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.

The circulation of blood through the CORONARY VESSELS of the HEART.

The veins and arteries of the HEART.

The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.

A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.

A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.

PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.

A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.

A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.

The circulation of the BLOOD through the MICROVASCULAR NETWORK.

Paracrine substances produced by the VASCULAR ENDOTHELIUM with VASCULAR SMOOTH MUSCLE relaxation (VASODILATION) activities. Several factors have been identified, including NITRIC OXIDE and PROSTACYCLIN.

The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Arteries which arise from the abdominal aorta and distribute to most of the intestines.

A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.

The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)

A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Drugs used to cause constriction of the blood vessels.

A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.

Recording of change in the size of a part as modified by the circulation in it.

The innermost layer of the three meninges covering the brain and spinal cord. It is the fine vascular membrane that lies under the ARACHNOID and the DURA MATER.

Endogenously-synthesized compounds that influence biological processes not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS.

Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease.

An essential amino acid that is physiologically active in the L-form.

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.

The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

The circulation of the BLOOD through the LUNGS.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

An agent that blocks the release of adrenergic transmitters and may have other actions. It was formerly used as an antihypertensive agent, but is now proposed as an anti-arrhythmic.

A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)

The nonstriated involuntary muscle tissue of blood vessels.

The vessels carrying blood away from the heart.

The number of times the HEART VENTRICLES contract per unit of time, usually per minute.

A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.

An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.

The process of exocrine secretion of the SWEAT GLANDS, including the aqueous sweat from the ECCRINE GLANDS and the complex viscous fluids of the APOCRINE GLANDS.

The arterial blood vessels supplying the CEREBRUM.

The TEMPERATURE at the outer surface of the body.

An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.

Relatively complete absence of oxygen in one or more tissues.

The recording of muscular movements. The apparatus is called a myograph, the record or tracing, a myogram. (From Stedman, 25th ed)

Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.

The circulation of the BLOOD through the vessels of the KIDNEY.

Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.

The processes of heating and cooling that an organism uses to control its temperature.

A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.

The circulation of blood through the BLOOD VESSELS of the BRAIN.

A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)

A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.

Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)

A transient reddening of the face that may be due to fever, certain drugs, exertion, stress, or a disease process.

Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).

Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).

An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.

Compounds that bind to and block the stimulation of PURINERGIC P1 RECEPTORS.

An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.

The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.

Central retinal artery and its branches. It arises from the ophthalmic artery, pierces the optic nerve and runs through its center, enters the eye through the porus opticus and branches to supply the retina.

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)

A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)

The circulation of blood through the BLOOD VESSELS supplying the abdominal VISCERA.

Treatment process involving the injection of fluid into an organ or tissue.

A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)

The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)

A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.

The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.

A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.

The functions of the skin in the human and animal body. It includes the pigmentation of the skin.

Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.

Therapeutic introduction of ions of soluble salts into tissues by means of electric current. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. It has nothing to do with ION EXCHANGE; AIR IONIZATION nor PHONOPHORESIS, none of which requires current.

Arteries which supply the dura mater.

The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)

The part of the face that is below the eye and to the side of the nose and mouth.

Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.

The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.

An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.

The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.

Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.

Elements of limited time intervals, contributing to particular results or situations.

An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.

A class of cell surface receptors that prefer ADENOSINE to other endogenous PURINES. Purinergic P1 receptors are widespread in the body including the cardiovascular, respiratory, immune, and nervous systems. There are at least two pharmacologically distinguishable types (A1 and A2, or Ri and Ra).

A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.

Delivery of drugs into an artery.

A group of organic sulfur-containing nitrites, alkyl thionitrites. S-Nitrosothiols include compounds such as S-NITROSO-N-ACETYLPENICILLAMINE and S-NITROSOGLUTATHIONE.

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).

An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.

A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.

Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.

Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)

Potassium channels whose activation is dependent on intracellular calcium concentrations.

Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

The main trunk of the systemic arteries.

Abnormal enlargement or swelling of a KIDNEY due to dilation of the KIDNEY CALICES and the KIDNEY PELVIS. It is often associated with obstruction of the URETER or chronic kidney diseases that prevents normal drainage of urine into the URINARY BLADDER.

The measure of the level of heat of a human or animal.

A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.

A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.

A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.

The main artery of the thigh, a continuation of the external iliac artery.

The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.

A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.

A subclass of adenosine A2 receptors found in LEUKOCYTES, the SPLEEN, the THYMUS and a variety of other tissues. It is generally considered to be a receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.

Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)

Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.

A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)

Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells.

The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).

A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.

A group of conditions that develop due to overexposure or overexertion in excessive environmental heat.

A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)

21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.

A 37-amino acid residue peptide isolated from the scorpion Leiurus quinquestriatus hebraeus. It is a neurotoxin that inhibits calcium activated potassium channels.

A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.

Nerve cells where transmission is mediated by NITRIC OXIDE.

A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)

The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.

A potassium-selective ion channel blocker. (From J Gen Phys 1994;104(1):173-90)

A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.

An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.

A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

Cell surface receptors that bind BRADYKININ and related KININS with high affinity and trigger intracellular changes which influence the behavior of cells. The identified receptor types (B-1 and B-2, or BK-1 and BK-2) recognize endogenous KALLIDIN; t-kinins; and certain bradykinin fragments as well as bradykinin itself.

Microscopy in which television cameras are used to brighten magnified images that are otherwise too dark to be seen with the naked eye. It is used frequently in TELEPATHOLOGY.

A colorimetric reagent for iron, manganese, titanium, molybdenum, and complexes of zirconium. (From Merck Index, 11th ed)

An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.

Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.

Left bronchial arteries arise from the thoracic aorta, the right from the first aortic intercostal or the upper left bronchial artery; they supply the bronchi and the lower trachea.

A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)

Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.

The application of heat to raise the temperature of the environment, ambient or local, or the systems for accomplishing this effect. It is distinguished from HEAT, the physical property and principle of physics.

Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.

An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.

A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.

An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.

The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Heterocyclic compounds in which an oxygen is attached to a cyclic nitrogen.

Diet modification and physical exercise to improve the ability of animals to perform physical activities.

Use of electric potential or currents to elicit biological responses.

A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).

A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.

A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)

The inferior part of the lower extremity between the KNEE and the ANKLE.

Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

A subtype of endothelin receptor found predominantly in the VASCULAR SMOOTH MUSCLE. It has a high affinity for ENDOTHELIN-1 and ENDOTHELIN-2.

A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.

A water-soluble polypeptide (molecular weight approximately 8,000) extractable from the corpus luteum of pregnancy. It produces relaxation of the pubic symphysis and dilation of the uterine cervix in certain animal species. Its role in the human pregnant female is uncertain. (Dorland, 28th ed)

A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).

Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.

The finer blood vessels of the vasculature that are generally less than 100 microns in internal diameter.

A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.

A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.

A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.

A calcium channel blocker that is a class IV anti-arrhythmia agent.

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.

The active metabolite of ENALAPRIL and a potent intravenously administered angiotensin-converting enzyme inhibitor. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion.

A constitutively expressed subtype of bradykinin receptor that may play a role in the acute phase of the inflammatory and pain response. It has high specificity for intact forms of BRADYKININ and KALLIDIN. The receptor is coupled to G-PROTEIN, GQ-G11 ALPHA FAMILY and G-PROTEIN, GI-GO ALPHA FAMILY signaling proteins.

The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.

A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)

Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.

The hollow, muscular organ that maintains the circulation of the blood.

Inorganic oxides that contain nitrogen.

Phospholamban is present in endothelial cells and modulates endothelium-dependent relaxation. Evidence from phospholamban gene-ablated mice. (1/8444)

Vascular endothelial cells regulate vascular smooth muscle tone through Ca2+-dependent production and release of vasoactive molecules. Phospholamban (PLB) is a 24- to 27-kDa phosphoprotein that modulates activity of the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA). Expression of PLB is reportedly limited to cardiac, slow-twitch skeletal and smooth muscle in which PLB is an important regulator of [Ca2+]i and contractility in these muscles. In the present study, we report the existence of PLB in the vascular endothelium, a nonmuscle tissue, and provide functional data on PLB regulation of vascular contractility through its actions in the endothelium. Endothelium-dependent relaxation to acetylcholine was attenuated in aorta of PLB-deficient (PLB-KO) mice compared with wild-type (WT) controls. This effect was not due to actions of nitric oxide on the smooth muscle, because sodium nitroprusside-mediated relaxation in either denuded or endothelium-intact aortas was unaffected by PLB ablation. Relative to denuded vessels, relaxation to forskolin was enhanced in WT endothelium-intact aortas. The endothelium-dependent component of this relaxation was attenuated in PLB-KO aortas. To investigate whether these changes were due to PLB, WT mouse aorta endothelial cells were isolated. Both reverse transcriptase-polymerase chain reaction and Western blot analyses revealed the presence of PLB in endothelial cells, which were shown to be >98% pure by diI-acetylated LDL uptake and nuclear counterstaining. These data indicate that PLB is present and modulates vascular function as a result of its actions in endothelial cells. The presence of PLB in endothelial cells opens new fields for investigation of Ca2+ regulatory pathways in nonmuscle cells and for modulation of endothelial-vascular interactions. (+info)

Loss of endothelium and receptor-mediated dilation in pial arterioles of rats fed a short-term high salt diet. (2/8444)

A high salt diet often is regarded as an accessory risk factor in hypertension, coincidental to the deleterious effect of high blood pressure on vasodilator function. The aim of this study was to determine whether short-term ingestion of a high salt diet per se impairs vasodilator function in the cerebral circulation independent of blood pressure changes. Adult Sprague-Dawley rats were fed a normal salt (0.8%) or high salt (4%) diet for 3 days. Mean arterial pressures were similar in the normal and high salt groups (123+/-2 and 125+/-2 mm Hg, respectively). Subsequently, the responses of the in situ pial arterioles to acetylcholine, iloprost, and sodium nitroprusside were determined in cranial windows using intravital videomicroscopy. Pial arterioles of rats fed normal and high salt diets showed similar resting diameters of 69+/-2 and 72+/-3 microm, respectively, but their reactivity patterns to vasodilator stimuli were markedly different. Arterioles of rats fed a normal salt diet dilated progressively up to 17+/-3% in response to the endothelium-dependent agent acetylcholine (10(-9) to 10(-6) mol/L) and dilated by 22+/-2% in response to the prostaglandin I2 receptor agonist iloprost (3x10(-11) mol/L). In contrast, pial arterioles of rats fed a high salt diet constricted by 4+/-3% and 8+/-2% in response to acetylcholine and iloprost, respectively. Sodium nitroprusside (10(-6) mol/L), a nitric oxide donor, dilated pial arterioles of rats fed low and high salt diets by a similar amount (19+/-3% and 16+/-2%, respectively), suggesting that signaling mechanisms for dilation distal to the vascular smooth muscle membrane were intact after high salt intake. These results provide the first evidence that the short-term ingestion of a high salt diet may severely impair the vasodilator function of the in situ cerebral microcirculation independent of blood pressure elevation. (+info)

Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. (3/8444)

We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates nitric oxide (NO) release in the rat kidney. To further investigate whether the NO-cGMP pathway is involved in the mechanisms of AM-induced vasodilation, we examined the effects of E-4021, a cGMP-specific phosphodiesterase inhibitor, on AM-induced vasorelaxation in aortic rings and perfused kidneys isolated from Wistar rats. We also measured NO release from the kidneys using a chemiluminescence assay. AM (10(-10) to 10(-7) mol/L) relaxed the aorta precontracted with phenylephrine in a dose-dependent manner. Denudation of endothelium (E) attenuated the vasodilatory action of AM (10(-7) mol/L AM: intact (E+) -25.7+/-5.2% versus denuded (E-) -7. 8+/-0.6%, P<0.05). On the other hand, pretreatment with 10(-8) mol/L E-4021 augmented AM-induced vasorelaxation in the intact aorta (-49. 0+/-7.9%, P<0.05) but not in the denuded one. E-4021 also enhanced acetylcholine (ACh)-induced vasorelaxation in the rat intact aorta (10(-7) mol/L ACh -36.6+/-8.4% versus 10(-8) mol/L E-4021+10(-7) mol/L ACh -62.7+/-3.1%, P<0.05). In perfused kidneys, AM-induced vasorelaxation was also augmented by preincubation with E-4021 (10(-9) mol/L AM -15.4+/-0.6% versus 10(-8) mol/L E-4021+10(-9) mol/L AM -23.6+/-1.2%, P<0.01). AM significantly increased NO release from rat kidneys (DeltaNO: +11.3+/-0.8 fmol. min-1. g-1 kidney at 10(-9) mol/L AM), which was not affected by E-4021. E-4021 enhanced ACh-induced vasorelaxation (10(-9) mol/L ACh -9.7+/-1.7% versus 10(-8) mol/L E-4021+10(-9) mol/L ACh -18.8+/-2.9%, P<0.01) but did not affect ACh-induced NO release from the kidneys. In the aorta and the kidney, 10(-4) mol/L of NG-nitro-L-arginine methyl ester, an NO synthase inhibitor, and 10(-5) mol/L of methylene blue, a guanylate cyclase inhibitor, reduced the vasodilatory effect of AM. These results suggest that the NO-cGMP pathway is involved in the mechanism of AM-induced vasorelaxation, at least in the rat aorta and kidney. (+info)

Role of endothelin in the increased vascular tone of patients with essential hypertension. (4/8444)

We investigated the possible role of endothelin in the increased vasoconstrictor tone of hypertensive patients using antagonists of endothelin receptors. Forearm blood flow (FBF) responses (strain-gauge plethysmography) to intraarterial infusion of blockers of endothelin-A (ETA) (BQ-123) and endothelin-B (ETB) (BQ-788) receptors, separately and in combination, were measured in hypertensive patients and normotensive control subjects. In healthy subjects, BQ-123 alone or in combination with BQ-788 did not significantly modify FBF (P=0.78 and P=0.63, respectively). In hypertensive patients, in contrast, BQ-123 increased FBF by 33+/-7% (P<0.001 versus baseline), and the combination of BQ-123 and BQ-788 resulted in a greater vasodilator response (63+/-12%; P=0.006 versus BQ-123 alone in the same subjects). BQ-788 produced a divergent vasoactive effect in the two groups, with a decrease of FBF (17+/-5%; P=0.004 versus baseline) in control subjects and transient vasodilation (15+/-7% after 20 minutes) in hypertensive patients (P<0.001, hypertensives versus controls). The vasoconstrictor response to endothelin-1 was slightly higher (P=0.04) in hypertensive patients (46+/-4%) than in control subjects (32+/-4%). Our data indicate that patients with essential hypertension have increased vascular endothelin activity, which may be of pathophysiological relevance to their increased vascular tone. In these patients, nonselective ETA and ETB blockade seems to produce a greater vasodilator effect than selective ETA blockade. (+info)

Microvascular function relates to insulin sensitivity and blood pressure in normal subjects. (5/8444)

BACKGROUND: A strong but presently unexplained inverse association between blood pressure and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a common antecedent linking insulin sensitivity to blood pressure. To test this hypothesis, we studied 18 normotensive and glucose-tolerant subjects showing a wide range in insulin sensitivity as assessed with the hyperinsulinemic, euglycemic clamp technique. METHODS AND RESULTS: Blood pressure was measured by 24-hour ambulatory blood pressure monitoring. Videomicroscopy was used to measure skin capillary density and capillary recruitment after arterial occlusion. Skin blood flow responses after iontophoresis of acetylcholine and sodium nitroprusside were evaluated by laser Doppler flowmetry. Insulin sensitivity correlated with 24-hour systolic blood pressure (24-hour SBP; r=-0.50, P<0.05). Capillary recruitment and acetylcholine-mediated vasodilatation were strongly and positively related to insulin sensitivity (r=0.84, P<0.001; r=0.78, P<0.001, respectively), and capillary recruitment was inversely related to 24-hour SBP (r=-0.53, P<0.05). Waist-to-hip ratio showed strong associations with insulin sensitivity, blood pressure, and the measures of microvascular function but did not confound the associations between these variables. Subsequent regression analysis showed that the association between insulin sensitivity and blood pressure was not independent of the estimates of microvascular function, and part of the variation in both blood pressure (R2=38%) and insulin sensitivity (R2=71%) could be explained by microvascular function. CONCLUSIONS: Insulin sensitivity and blood pressure are associated well within the physiological range. Microvascular function strongly relates to both, consistent with a central role in linking these variables. (+info)

Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation. (6/8444)

BACKGROUND: The cardiovascular complications of Marfan syndrome arise due to alterations in the structural and functional properties of fibrillin, a constituent of vascular connective tissues. Fibrillin-containing microfibrils are closely associated with arterial endothelial cells, indicating a possible functional role for fibrillin in the endothelium. Plasma concentrations of endothelial cell products are elevated in Marfan subjects, which indirectly indicates endothelial dysfunction. This study directly assessed flow- and agonist-mediated endothelium-dependent brachial artery reactivity in Marfan subjects. METHODS AND RESULTS: In 20 Marfan and 20 control subjects, brachial artery diameter, blood flow, and blood pressure were measured by ultrasonic wall tracking, Doppler ultrasound, and photoplethysmography, respectively. Measurements were taken during hand hyperemia (a stimulus for endothelium-derived nitric oxide [NO] release in the upstream brachial artery) and after sublingual administration of the endothelium-independent vasodilator nitroglycerin. In 9 Marfan and 6 control subjects, the above parameters were also assessed during intra-arterial infusions of acetylcholine and bradykinin (agonists that stimulate NO production) and NG-monomethyl-L-arginine (L-NMMA, an inhibitor of NO production). Flow-mediated responses differed markedly between Marfan and control subjects (-1.6+/-3.5% versus 6. 50+/-4.1%, respectively; P<0.0001), whereas nitroglycerin produced similar vasodilation (14.2+/-5.7% versus 15.2+/-7.8%; P=NS). Agonist-induced vasodilation to incremental intra-arterial infusions of acetylcholine and bradykinin were not significantly different between Marfan and control subjects, and intra-arterial L-NMMA produced similar reductions in brachial artery diameter in both groups. CONCLUSIONS: These data demonstrate impaired flow-mediated but preserved agonist-mediated endothelium-dependent vasodilation in Marfan subjects and suggest preservation of basal NO release. Selective loss of flow-mediated dilation suggests a role for fibrillin in endothelial cell mechanotransduction. (+info)

Neurogenic vasodilatation of canine isolated small labial arteries. (7/8444)

Mechanisms underlying vasodilatation to nerve stimulation by electrical pulses and nicotine were analyzed in isolated canine small labial arteries. Transmural electrical stimulation (5 and 20 Hz) produced a contraction followed by a relaxation in labial arterial strips denuded of the endothelium, partially contracted with prostaglandin F2alpha. The contraction was abolished by prazosin or combined treatment with alpha, beta-methylene ATP. In the treated strips, neurogenic relaxation was abolished by NG-nitro-L-arginine (L-NA), a nitric oxide (NO) synthase inhibitor, and restored by L-arginine. The D-enantiomers were without effect. Nicotine (10(-4) M) also relaxed the arteries, in which the contractile response was abolished by prazosin and alpha, beta-methylene ATP. The relaxant response was attenuated but not abolished by L-NA; the inhibition was reversed by L-arginine. The remaining relaxation by nicotine was abolished by calcitonin gene-related peptide (CGRP)-[8 to 37], a CGRP1 receptor antagonist. Relaxations elicited by a lower concentration of nicotine (2 x 10(-5) M) sufficient to produce similar magnitudes of response to those induced by 5-Hz electrical nerve stimulation were also inhibited partially by L-NA. Histochemical study with the NADPH-diaphorase method demonstrated positively stained nerve fibers and bundles in the arterial wall, suggesting the presence of neuronal NO synthase. It is concluded that the relaxation induced by electrical nerve stimulation of small labial arteries is mediated exclusively by NO synthesized from L-arginine in nerve terminals, whereas nicotine in the concentrations used evokes relaxations by a mediation of nerve-derived NO and also CGRP, possibly from sensory nerves. The reason why nicotine but not electrical pulses stimulates sensory nerves and elicits vasorelaxation remains unsolved. (+info)

Relaxation of endothelin-1-induced pulmonary arterial constriction by niflumic acid and NPPB: mechanism(s) independent of chloride channel block. (8/8444)

We investigated the effects of the Cl- channel blockers niflumic acid, 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) and 4, 4'-diisothiocyanatostilbene-2,2'-disulphonic acid (DIDS) on endothelin-1 (ET-1)-induced constriction of rat small pulmonary arteries (diameter 100-400 microm) in vitro, following endothelium removal. ET-1 (30 nM) induced a sustained constriction of rat pulmonary arteries in physiological salt solution. Arteries preconstricted with ET-1 were relaxed by niflumic acid (IC50: 35.8 microM) and NPPB (IC50: 21.1 microM) in a reversible and concentration-dependent manner. However, at concentrations known to block Ca++-activated Cl- channels, DIDS (+info)

The spinal cord has both vasodilation and vasoconstriction nerves. The neurons that control vascular vasodilation originate in ... These approaches to the mechanism of vasodilation are not mutually exclusive. Vasodilation directly affects the relationship ... Vasodilation is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in ... Vasodilation works to decrease TPR and blood pressure through relaxation of smooth muscle cells in the tunica media layer of ...

https://en.wikipedia.org/wiki/Vasodilation

Ramanlal R, Gupta V (January 2022). "Physiology, Vasodilation". StatPearls. Treasure Island (FL): StatPearls Publishing. Felker ... which has numerous functions in the body including vasodilation - i.e. widening of the vessels. Nitric oxide reacts with other ... Nitroglycerin and other nitrogen oxide use have been a strong influence on vasodilation, cell permeability, inflammation, and ...

https://en.wikipedia.org/wiki/Cardiovascular_disease_in_women

Arteriolar vasodilation occurs. The smooth muscle walls of the arterioles relax allowing increased blood flow through the ...

https://en.wikipedia.org/wiki/Thermoregulation_in_humans

"Vasodilation and Vasoconstriction: Real Story." Vasodilation and Vasoconstriction. 2011. Web. 21 May 2012. University of ... In vasodilation the blood vessels dilate to allow more blood flow. The smooth muscle cells are relaxed to increase the diameter ... Like vasoconstriction, vasodilation can be caused by internal and external factors. For example, nitric oxide, found in food, ... Vasodilation is also triggered for thermoregulation to provide heat dissipation. The Starling equation describes the flow of a ...

https://en.wikipedia.org/wiki/Surface_chemistry_of_microvasculature

The mechanisms of vasodilation are predominantly local metabolites and myogenic effects. Increased metabolic activity of the ... These changes cause significant vasodilation. The reverse occurs when metabolic activity is slowed and these substances wash ... These vasodilators released from the tissue act on local arterioles causing vasodilation, this causes a decrease in vascular ... this then elicits arteriolar vasodilation consequently, creating a pathway of least resistance so blood flow can be precisely ...

https://en.wikipedia.org/wiki/Hyperaemia

Both of these factors affect pH and, in turn, the balance between vasodilation versus vasoconstriction in the brain. So, the ... In response to the blood flow interruption, a temporary compensatory vasodilation occurs as soon as blood flow has resumed, ... Vasodilation Vasoconstriction Vascular resistance "CV Physiology , Local Regulation of Blood Flow". www.cvphysiology.com. ... While nitric oxide causes vasodilation, endothelin-1 causes vasoconstriction. Below are several examples of differing types of ...

https://en.wikipedia.org/wiki/Local_blood_flow_regulation

This causes vasodilation and improves hemodynamics. DATS is a promising treatment for cardiac arrhythmias through its ability ...

https://en.wikipedia.org/wiki/Diallyl_trisulfide

Vasodilation and vasoconstriction are complex phenomena; they are functions not merely of the fluid mechanics of pressure and ...

https://en.wikipedia.org/wiki/Compliance_(physiology)

vasodilation The widening of blood vessels. vector vegetative reproduction Any type of asexual reproduction performed by an ...

https://en.wikipedia.org/wiki/Glossary_of_biology

This cold-induced vasodilation increases blood flow and subsequently the temperature of the fingers. A new phase of ... The hunting reaction or hunting response is a process of alternating vasoconstriction and vasodilation in extremities exposed ... Hypothermia Thermoregulation Axon reflex Raynaud's syndrome Daanen, H.A.M. (2003). "Finger cold-induced vasodilation: a review ... reduced mean temperature of the digits and a prolonged time of cold exposure prior to initial vasodilation), thus putting the ...

https://en.wikipedia.org/wiki/Hunting_reaction

The smooth muscle relaxation leads to vasodilation. Inhibition of neutrophil activation and chemotaxis H2-receptor antagonist ... T-cell proliferation and cytokine production Vasodilation - PKA activity causes phosphorylation of MLCK, decreasing its ...

https://en.wikipedia.org/wiki/Histamine_H2_receptor

Jacobs B, Dussor G (December 2016). "Neurovascular contributions to migraine: Moving beyond vasodilation". Neuroscience. 338: ...

https://en.wikipedia.org/wiki/Migraine

AT2R agonists cause vasodilation, exerting hypotensive effects. In animal models of ischemia, activation of AT2R is protective ... In models of Ang II-dependent hypertension, endothelium-dependent vasodilation is reduced. Dysfunction of ion channels is also ... which impairs vasodilation. During sodium intake, an increased production of NO in the kidneys and peripheral vasculature is ...

https://en.wikipedia.org/wiki/Hypertension_and_the_brain

Vasoconstriction Vasodilation Vasospasm Haddock RE, Hill CE. Rhythmicity in arterial smooth muscle. J Physiol (Lond ). 2005; ...

https://en.wikipedia.org/wiki/Vasomotion

Increased heart rate and heart muscle contraction are associated with the β1 receptors; however, β2 cause vasodilation in the ...

https://en.wikipedia.org/wiki/Beta-adrenergic_agonist

Cause Vasodilation in the systemic arterial circulation. Cause Vasoconstriction of the Liver sinusoidal and pulmonary venous ... These studies find that selective (but not entirely specific) CYP epoxygenase-inhibiting drugs reduce human vasodilation ... contribute in small or large part to vasodilation responses and by this action promote blood flow to tissues and function in ... express hyperactive sEH and show reduced vasodilation responses to bradykinin. Other studies find that women with pregnancy- ...

https://en.wikipedia.org/wiki/Epoxyeicosatrienoic_acid

Most notably, this enzyme is involved in vasodilation. In humans, it is encoded by the genes GUCY1A2, GUCY1A3, GUCY1B2 and ...

https://en.wikipedia.org/wiki/Soluble_guanylyl_cyclase

The triple response consists of three aspects: Red spot, caused by capillary vasodilation. Flare, a redness in the surrounding ... but some time at caused by capillary vasodilation. The triple response of Lewis is particularly sensitive in people with ... As extremities cool, the 'hunting response of Lewis' (alternating vasoconstriction and vasodilation) occurs, ending with ...

https://en.wikipedia.org/wiki/Triple_response_of_Lewis

They have anti-inflammatory, sedative and vasodilation effects.[citation needed] The fruit of Prunus mahaleb is inedible. ...

https://en.wikipedia.org/wiki/Prunus_mahaleb

Murad F (July 1986). "Cyclic Guanosine Monophosphate as a Mediator of Vasodilation". J. Clin. Investig. 78 (1): 1-5. doi: ... In physiology research, sodium nitroprusside is frequently used to test endothelium-independent vasodilation. Iontophoresis, ... preventing the systemic effects listed above but still inducing local microvascular vasodilation. Sodium nitroprusside is also ...

https://en.wikipedia.org/wiki/Sodium_nitroprusside

In fact, recent studies indicate that vasodilation, the expansion of the blood capillaries (vessels) to allow more blood flow, ... Heat therapy is contraindicated in case of acute injury and bleeding disorders (because of vasodilation), tissues with a severe ... Heat creates higher tissue temperatures, which produces vasodilation that increases the supply of oxygen and nutrients and the ... All devices primarily provide heat to promote vasodilation. Infrared radiation Infrared radiation is a convenient system to ...

https://en.wikipedia.org/wiki/Heat_therapy

Increased endothelin and decreased vasodilation have been documented. Jimenez and Derk describe three theories about the ...

https://en.wikipedia.org/wiki/Systemic_scleroderma

Nitric oxide results in vasodilation of blood vessels. Chemical stimulation of angiogenesis is performed by various angiogenic ...

https://en.wikipedia.org/wiki/Angiogenesis

The expansion of blood vessels is called vasodilation. Food also plays a role. In winter, one tends to consume more calories, ...

https://en.wikipedia.org/wiki/Springtime_lethargy

... possibly through direct vasodilation. There are also reports that it may cause green discolouration of the urine. Although ... Additional side effects include low blood pressure related to vasodilation, transient apnea following induction doses, and ... "Mechanisms whereby propofol mediates peripheral vasodilation in humans. Sympathoinhibition or direct vascular relaxation?". ...

https://en.wikipedia.org/wiki/Propofol

Conjunctival vessels also show proliferation, increased permeability and vasodilation. Based on severity, authors have ...

https://en.wikipedia.org/wiki/Vernal_keratoconjunctivitis

This area of the skin will become warmer because of vasodilation (loss of vasoconstriction). Depression of the vasomotor center ... Vasoconstriction Vasodilation "Vasomotor" at Dorland's Medical Dictionary WebMD (2009). "vasomotor". Webster's New World ... resulting in vasodilation. Normally, α-adrenergic receptors predominates in smooth muscle of resistance vessels. Endothelin, ...

https://en.wikipedia.org/wiki/Vasomotor

MMPs and NO induce vasodilation in the cerebral vasculature. Cytokines induce capillary wall changes in the blood brain barrier ...

https://en.wikipedia.org/wiki/Viral_meningitis

This increases biosynthesis of cyclic GMP, resulting in vasodilation. Riociguat, another drug stimulating sGC, but with a ...

https://en.wikipedia.org/wiki/Cinaciguat

Its primary action is vasodilation due to α1 blockade. Non-selective α-blockers can cause a much more pronounced reflex ...

https://en.wikipedia.org/wiki/Phentolamine

In this article, learn about what causes vasodilation and how it can affect a persons health. ... Vasodilation refers to a widening of the bodys blood vessels. ... Vasodilation may occur when a person exercises.. Vasodilation ... Vasodilation assists inflammation by enabling the delivery of oxygen and nutrients to damaged tissues. Vasodilation is what ... In other cases, vasodilation may be what requires treatment.. Medications that induce vasodilation. Vasodilators are ...

https://www.medicalnewstoday.com/articles/327402?utm_source=ReadNext

Cold-induced vasodilation (CIVD) is an acute increase in peripheral blood flow observed during cold exposures. It is ... Effect of body temperature on cold induced vasodilation Eur J Appl Physiol. 2008 Oct;104(3):491-9. doi: 10.1007/s00421-008-0798 ... Cold-induced vasodilation (CIVD) is an acute increase in peripheral blood flow observed during cold exposures. It is ...

https://pubmed.ncbi.nlm.nih.gov/18568361/

Reactive Vasodilation Predicts Mortality in Primary Systemic Light Chain (AL) Amyloidosis. Tuesday, August 13, 2019 ... The translational value for cardiac transplantation of this prospective multi-centre clinical study of vasodilation in ...

https://www.ctsnet.org/jans/reactive-vasodilation-predicts-mortality-primary-systemic-light-chain-al-amyloidosis

Thallium-201 Myocardial Imaging during Coronary Vasodilation Induced by Oral Dipyridamole. K. Lance Gould, Sherman G. Sorenson ... Thallium-201 Myocardial Imaging during Coronary Vasodilation Induced by Oral Dipyridamole. K. Lance Gould, Sherman G. Sorenson ... Thallium-201 Myocardial Imaging during Coronary Vasodilation Induced by Oral Dipyridamole Message Subject (Your Name) has sent ... Thallium-201 Myocardial Imaging during Coronary Vasodilation Induced by Oral Dipyridamole. K. Lance Gould, Sherman G. Sorenson ...

https://jnm.snmjournals.org/content/27/1/31

Pulmonary vasodilation by sildenafil in acute intermediate-high risk pulmonary embolism: a randomized explorative trial. ... BACKGROUND: To investigate if acute pulmonary vasodilation by sildenafil improves right ventricular function in patients with ...

https://pure.au.dk/portal/en/publications/pulmonary-vasodilation-by-sildenafil-in-acute-intermediatehigh-risk-pulmonary-embolism

Selective Pulmonary Vasodilation Induced by Aerosolized Zaprinast Fumito Ichinose, MD; Fumito Ichinose, MD ... causes selective pulmonary vasodilation. The duration of vasodilation with zaprinast inhalation is dose dependent and ... The duration of the vasodilation caused by breathing an aerosol of zaprinast is markedly longer than that of inhaled NO alone. ... Welte M, Zwissler B, Habazettl H, Messmer K: PGI sub 2 aerosol versus nitric oxide for selective pulmonary vasodilation in ...

https://pubs.asahq.org/anesthesiology/article/88/2/410/36514/Selective-Pulmonary-Vasodilation-Induced-by

Further, impaired cerebral vasodilation has been linked to reduced cognitive activity in older adults with depression. However ... PURPOSE: We tested the hypothesis that greater hypercapnia-induced cerebral vasodilation would be related to greater fluid ... Further, impaired cerebral vasodilation has been linked to reduced cognitive activity in older adults with depression. However ... PURPOSE: We tested the hypothesis that greater hypercapnia-induced cerebral vasodilation would be related to greater fluid ...

https://digitalcommons.wku.edu/ijesab/vol2/iss12/60/

Endothelial-dependent vasodilation is impaired in patients with systemic sclerosis, as assessed by low dose iontophoresis. ... Endothelial-dependent vasodilation is impaired in patients with systemic sclerosis, as assessed by low dose iontophoresis. ...

https://eprints.lancs.ac.uk/id/eprint/9678/

Dive into the research topics of Reduced endothelium-dependent peripheral vasodilation in the aged. Together they form a ...

https://moh-it.pure.elsevier.com/en/publications/reduced-endothelium-dependent-peripheral-vasodilation-in-the-aged

Effects of chronic and acute consumption of fruit- and vegetable-puree-based drinks on vasodilation, risk factors for CVD and ... There was a trend towards increased vasodilation following both chronic and acute FVPD consumption. All volunteers were ... Overall, there was a non-significant trend towards increased endothelium-dependent vasodilation following both acute and ... and vegetable-puree-based drinks on vasodilation, risk factors for CVD and the response as a result of the eNOS G298T ...

https://nrl.northumbria.ac.uk/id/eprint/4563/

Moskowitz, M. A., & Cutrer, F. M. (1994). Nitric oxide in cerebral vasodilation and headache. Cephalalgia, 14(6), 394-395. ... Moskowitz, M. A. ; Cutrer, F. M. / Nitric oxide in cerebral vasodilation and headache. In: Cephalalgia. 1994 ; Vol. 14, No. 6. ... Moskowitz, MA & Cutrer, FM 1994, Nitric oxide in cerebral vasodilation and headache, Cephalalgia, vol. 14, no. 6, pp. 394-395 ... Nitric oxide in cerebral vasodilation and headache. Cephalalgia. 1994;14(6):394-395. doi: 10.1046/j.1468-2982.1994.1406391-6.x ...

https://mayoclinic.pure.elsevier.com/en/publications/nitric-oxide-in-cerebral-vasodilation-and-headache-2

... : Anticoagulation, Immunosuppression, or Vasodilation? * ... Managing Diffuse Peripheral Ischemia in Antiphospholipid Syndrome: Anticoagulation, Immunosuppression, or Vasodilation?. ...

http://www.medscape.com/viewarticle/948988

Vasodilation. Widening of the interior diameter of blood vessels.. Vasopressor. Of, relating to, or causing constriction of ...

https://www.cdc.gov/niosh/ershdb/glossary.html

In patients with circulatory shock, use of oxycodone hydrochloride tablets may cause vasodilation that can further reduce ... Nervous system disorders: hypertonia, hypoesthesia, migraine, neuralgia, tremor, vasodilation Psychiatric disorders: agitation ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cc23de03-2569-920f-e053-2995a90a3699

The effect of l-arginine on acetylcholine-induced vasodilation difers between the coronary and forearm vasculatures in humans. ... The effect of l-arginine on acetylcholine-induced vasodilation difers between the coronary and forearm vasculatures in humans. ... The effect of l-arginine on acetylcholine-induced vasodilation difers between the coronary and forearm vasculatures in humans. ... The effect of l-arginine on acetylcholine-induced vasodilation difers between the coronary and forearm vasculatures in humans. ...

https://kyushu-u.pure.elsevier.com/en/publications/effect-of-l-arginine-on-acetylcholine-induced-endothelium-depende

In isolated mouse hearts, both Empa and Cana induced vasodilation. In ischemia-reperfusion studies of the isolated heart, Empa ... In isolated mouse hearts, Empa and Cana, but not Dapa, induced vasodilation. In ischemia-reperfusion studies of the isolated ... Vasodilation. Several studies have addressed the effects of SGLT2i in the isolated perfused heart. Acute coronary vasodilation ... Vasodilation. The effects of Dapa on endothelial cell- and SMC- dependent vascular tone in various models have been studied. ...

https://www.frontiersin.org/articles/10.3389/fphys.2018.01575/full

Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb. J. Wong, P. A. Vanderford, J. R. Fineman, R. Chang, S ... Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb. / Wong, J.; Vanderford, P. A.; Fineman, J. R. et al. ... Wong, J., Vanderford, P. A., Fineman, J. R., Chang, R., & Soifer, S. J. (1993). Endothelin-1 produces pulmonary vasodilation in ... Wong, J, Vanderford, PA, Fineman, JR, Chang, R & Soifer, SJ 1993, Endothelin-1 produces pulmonary vasodilation in the intact ...

https://ohsu.pure.elsevier.com/en/publications/endothelin-1-produces-pulmonary-vasodilation-in-the-intact-newbor-2

Attenuation of hindlimb vasodilation in heat-stressed baboons during dehydration. / Thornton, R. M.; Proppe, D. W. ... Attenuation of hindlimb vasodilation in heat-stressed baboons during dehydration. American Journal of Physiology - Regulatory ... Thornton, R. M. ; Proppe, D. W. / Attenuation of hindlimb vasodilation in heat-stressed baboons during dehydration. In: ... Thornton, R. M., & Proppe, D. W. (1986). Attenuation of hindlimb vasodilation in heat-stressed baboons during dehydration. ...

https://scholars.uthscsa.edu/en/publications/attenuation-of-hindlimb-vasodilation-in-heat-stressed-baboons-dur

Vasodilation. Vasodilation ± balloon angioplasty. Severe. Vasodilation ± balloon angioplasty (rare). Vasodilation + balloon ...

https://emedicine.medscape.com/article/2500045-guidelines

vasodilation.. *Arsenic ingestion from contaminated beer has been reported to cause outbreaks of cardiomyopathy [Reynolds 1901 ...

https://www.atsdr.cdc.gov/csem/arsenic/physiologic_effects.html

Maximum Vasodilation. Increased Uptake of Amino Acids and Additional Nutrients. Adenosine 5′-Triphosphate (ATP) is a unique ... ATP increases vasodilation. ATP increases oxygen flow & L-Arginine uptake. ATP increases bioavailability of key nutrients ... ATP works to increase vasodilation by stimulating endogenous NO synthesis in striated muscle, and enhances the delivery of ...

https://blackdiamondsupplements.com/shop/plasmajet/

Plexigenic lesion going to vasodilation. Posted on November 4, 2019 at 11:12 am by Admin / ...

https://clevelandcliniclabs.com/about-us/pathology/pulmonary-pathology/plexigenic-lesion-going-to-vasodilation/

Core Champs L-Citrulline 2000mg supports vasodilation through nitric oxide production, helping to improve blood flow and muscle ... CORE CHAMPS L-CITRULLINE supports vasodilation through nitric oxide production, helping to improve blood flow and muscle pumps ... CORE CHAMPS L-CITRULLINE supports vasodilation through nitric oxide production, helping to improve blood flow and muscle pumps ...

https://jnknutrition.com/products/core-champs-l-citrulline-90-servings

Mehta, S., Stewart, D. J., Langleben, D., and Levy, R. D. Short-term pulmonary vasodilation with L-arginine in pulmonary ... L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol 1998;46: ... Effects of oral L-arginine on endothelium-dependent vasodilation and markers of inflammation in healthy postmenopausal women. J ... Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg ...

https://medlineplus.gov/spanish/druginfo/natural/875.html

Vasodilation ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=heart+or+cardiac+or+cardiovascular+or+cardiopulmonary+or+cerebrovascular+or+fatality&f1=TI&Startyear=&t1=1&s2=heart+or+cardiac+or+cardiovascular+or+cardiopulmonary+or+cerebrovascular+&terms=3&Adv=1&ct=&B1=Search&f2=KW&Limit=500&Sort=DP+DESC&whichdate=DP&D1=10&EndYear=&PageNo=15&RecNo=147&View=f&

Either increases toxicity of the other by additive vasodilation. Modify Therapy/Monitor Closely. Marked orthostatic hypotension ... Either increases toxicity of the other by additive vasodilation. Modify Therapy/Monitor Closely. Marked orthostatic hypotension ...

https://reference.medscape.com/drug/cabren-cardioplen-xl-felodipine-342375

I and the isolated compounds did not improve the impaired vasodilation associated with AGEs exposure. PPT, Fr. I and the ... Vasodilation Is the Subject Area "Vasodilation" applicable to this article? Yes. No. ...

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222101

Further, at the level of the neurovascular unit, SAH causes an inversion of neurovascular coupling from vasodilation to ... neuronal activation caused the anticipated increase in astrocytic endfoot Ca2+ and vasodilation. This vasodilation was greatly ... J. A. Filosa, A. D. Bonev, S. V. Straub et al., "Local potassium signaling couples neuronal activity to vasodilation in the ... For example, ischemia has been shown to impair cerebral artery function that may limit vasodilation [99, 100]. Further, global ...

https://www.hindawi.com/journals/srt/2013/819340/

Increased capillary permeability (third-spacing and vasodilation) can result in hypovolemic shock. Sinus tachycardia can be an ...

https://wwwn.cdc.gov/tsp/MMG/MMGDetails.aspx?mmgid=1424&toxid=3

Dive into the research topics of Role of primary afferents in spinal cord stimulation-induced vasodilation: Characterization ... Role of primary afferents in spinal cord stimulation-induced vasodilation: Characterization of fiber types. ...

https://experts.unthsc.edu/en/publications/role-of-primary-afferents-in-spinal-cord-stimulation-induced-vaso/fingerprints/

Vasoconstriction is the opposite of vasodilation. (medicalnewstoday.com)
Further, at the level of the neurovascular unit, SAH causes an inversion of neurovascular coupling from vasodilation to vasoconstriction. (hindawi.com)
Regardless of vessel size, vasomotor responses (i.e., vasodilation and vasoconstriction) of retinal arterioles were sensitive to the alpha2-AR antagonist rauwolscine. (tamu.edu)
Ethanol abuse, which is strongly associated with hypothermia, results in vasodilation and interferes with peripheral vasoconstriction, an important physiologic mechanism of defense against the cold. (cdc.gov)
The papillary dermis, closer to the epidermis and in contact with the basal lamina, forms the dermal papillae and it is connective tissue with abundant blood vessels for feeding the epidermis, but also for body temperature regulation by vasodilation and vasoconstriction. (uvigo.es)

CORE CHAMPS L-CITRULLINE supports vasodilation through nitric oxide production, helping to improve blood flow and muscle pumps during a workout. (jnknutrition.com)
Golanov, EV & Reis, DJ 1994, ' Nitric oxide and prostanoids participate in cerebral vasodilation elicited by electrical stimulation of the rostral ventrolateral medulla ', Journal of Cerebral Blood Flow and Metabolism , vol. 14, no. 3, pp. 492-502. (houstonmethodist.org)
Brimonidine evokes heterogeneous vasomotor response of retinal arterioles: diminished nitric oxide-mediated vasodilation when size goes small. (tamu.edu)
Arginine is converted to nitric oxide in the body and causes vasodilation, or relaxation of the blood vessels, which increases blood flow. (healthfully.com)
Nitric oxide causes blood vessels to open wider (vasodilation) and enable greater blood flow to the muscles. (fastandup.in)
This happens when the vasodilation of your penis veins occurs because of the setting off the activity of nitric oxide. (shop24kart.com)
Methylene blue is a guanylyl cyclase inhibitor that has been found to increase SVR and decrease vasopressor requirements in vasoplegic syndrome by inhibiting nitric oxide synthase (NOS), thus limiting the production of nitric oxide (NO) as well as inhibiting the enzyme guanylyl cyclase and preventing vasodilation 5 . (anesthesiaejournal.com)

The impaired endothelium-dependent vasodilation was prevented by long-term vitamin C administration. (who.int)

The widening of blood vessels during vasodilation promotes blood flow. (medicalnewstoday.com)
Vasodilation refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins. (fasting.ws)

Las personas usan L-arginina para el dolor de pecho y varios problemas de flujo de golpes, disfunción eréctil, presión arterial alta durante el embarazo y una enfermedad grave en bebés prematuros llamada enterocolitis necrotizante (NEC). (medlineplus.gov)
La ingesta de L-arginina puede reducir la presión arterial en personas sanas, personas con presión arterial alta y personas con presión arterial ligeramente alta con o sin diabetes. (medlineplus.gov)
Tomar L-arginina por vía intravenosa puede reducir la presión arterial en personas embarazadas con preeclampsia. (medlineplus.gov)
Arterial smooth muscle cell (myocyte) contraction reduces luminal diameter, leading to an increase in systemic blood pressure, whereas relaxation results in vasodilation that decreases blood pressure. (elifesciences.org)
It further overcomes arterial blockages by managing the contraction and vasodilation in the penile shaft. (heroes.app)
Adenosine receptor agonists also induce arterial vasodilation and hypotension. (medscape.com)

However, when NNA and IND were superfused together, the inhibition of the evoked vasodilation was comparable to that elicited by NNA alone. (houstonmethodist.org)
Acetylcholine causes cardiac inhibition, vasodilation, gastrointestinal peristalsis and other parasympathetic effects. (nutrimedical.com)

Pulmonary vasodilation by sildenafil in acute intermediat. (au.dk)
BACKGROUND: To investigate if acute pulmonary vasodilation by sildenafil improves right ventricular function in patients with acute intermediate-high risk pulmonary embolism (PE). (au.dk)

They contains a vasodilation of time and the penis at home with gradually. (frontroyalrealestateagents.com)
With the rising vasodilation impact, your penis affectability ascends because of higher blood in the tissues of the penis. (shop24kart.com)
Predictable blood stream to the penis because of vasodilation will bring about an expansion in size and length of the penis. (damianoecommerce.com)
The presence of the cGMP substance starts the essential time of the erection correspondence and that is to draw in you with vasodilation that maintains the penis vessels and the corridors to stream more blood into the penis tissues. (propharmacyshop.com)

Cognitive Function and Cerebral Vasodilation in Adults with Depression" by Salwa Shoaib, Rauchelle E. Richey et al. (wku.edu)
Further, impaired cerebral vasodilation has been linked to reduced cognitive activity in older adults with depression. (wku.edu)
We tested the hypothesis that greater hypercapnia-induced cerebral vasodilation would be related to greater fluid cognitive ability (i.e., the capacity to process and integrate new information) in young adults with MDD. (wku.edu)
Objective: To investigate long-term effects of oral vitamin C administration on the cerebral microvascular vasodilation in diabetes, using streptozotocin (STZ)-induced diabetic rats. (who.int)

Cold-induced vasodilation (CIVD) is an acute increase in peripheral blood flow observed during cold exposures. (nih.gov)
There was a trend towards increased vasodilation following both chronic and acute FVPD consumption. (northumbria.ac.uk)

For example, doctors sometimes induce vasodilation as a treatment for high blood pressure and related cardiovascular conditions. (medicalnewstoday.com)
A doctor may sometimes induce vasodilation as a treatment for high blood pressure , also known as hypertension , and its related conditions. (medicalnewstoday.com)
A doctor may also induce vasodilation to improve the effects of a drug or radiation therapy . (medicalnewstoday.com)
In order to prevent damage of the blood vessel into which the catheter is inserted, the present apparatus makes use of high frequency waves, e.g. harmless hydraulic or acoustic waves for producing and propagating a wave front through the fluid in the catheter and then in the blood vessel so as to induce vasodilation (cf. page 2, lines 23 to 29). (epo.org)

It is suggested that impaired acetylcholine-induced coronary and forearm vasodilation in patients with coronary artery disease and hypertension may not be related to a limited availability of l-arginine. (elsevier.com)
Halothane, isoflurane, and enflurane cause coronary vasodilation and cardiac depression. (silverchair.com)
The KATP channels play an important role in coronary vasodilation but apparently are not involved in cardiac depression caused by halothane, isoflurane, and enflurane in canine hearts in situ. (silverchair.com)
CitraNOX provides a blend of targeted nutrients designed to help dampen this stress by maintaining normal inflammatory balance, balancing NO levels, maintaining smooth muscle integrity, and optimizing vasodilation of key coronary arteries. (livebuilder.net)

Among 23 vaccinees with reported other nonserious adverse events during January 24--February 24, the most common signs and symptoms were fever (n = six), pruritus (n = five), rash (n = four), vasodilation (n = four), asthenia (n = three), headache/migraine (n = three), malaise (n = three), paresthesia (n = three), and redness at injection site (n = three). (cdc.gov)
Bioderma Sensibio AR BB cream: SPF 30 Anti-Redness sensitive skin-perfecting-soothing cream Sensibio AR BB Cream is the 1st skin-perfecting treatment that reduces redness by regulating vasodilation, protects from UV rays, evens out the complexion, moisturises and enhances radiance for flawless skin. (lloydspharmacy.ie)

Blood vessels dilate when they become warm, a process known as vasodilation. (thedelizze.com)
As soon as you permit the ice bathtub and your muscle tissues begin to heat up once more, the blood vessels dilate, or "vasodilation" happens. (everworldsite.com)

La ingesta de L-arginina por vía oral o intravenosa no mejora la función renal en la mayoría de las personas con ERC. (medlineplus.gov)

Twenty minutes later, stress imaging was performed at peak vasodilation, i.e. 70 seconds after regadenoson, 4 minutes after dipyridamole infusion and between 3-4 minutes of the adenosine infusion. (cdc.gov)
In contrast, dipyridamole induces vasodilation indirectly, by blocking adenosine reuptake and increasing endogenous adenosine. (cdc.gov)

Administration of the NO synthase inhibitor NG-nitro-L-arginine methyl ester abolished the brimonidine-induced vasodilation in first- and second-order arterioles. (tamu.edu)

Vasodilation assists inflammation by enabling the delivery of oxygen and nutrients to damaged tissues. (medicalnewstoday.com)
Vasodilation also plays an important role in inflammation. (medicalnewstoday.com)
Vasodilation assists inflammation by increasing blood flow to damaged cells and body tissues. (medicalnewstoday.com)

Vasodilation occurs naturally in response to low oxygen levels or increases in body temperature. (medicalnewstoday.com)
Vasodilation seems to be beneficial for this purpose because it increases the delivery of drugs or oxygen to the tissues that these treatments are designed to target. (medicalnewstoday.com)
Vasodilation enables the delivery of extra oxygen and nutrients to the muscles during exercise. (medicalnewstoday.com)
ATP works to increase vasodilation by stimulating endogenous NO synthesis in striated muscle, and enhances the delivery of oxygen, glucose and vital nutrients to skeletal muscles to immediately increase anabolism. (blackdiamondsupplements.com)

Heat syncope-sudden fainting caused by vasodilation-occurs in unacclimatized people standing in the heat or after 15-20 minutes of exercise. (cdc.gov)

Vasodilation is responsible for increased blood flow to tissues such as muscle fibers, which supports enhanced athletic performance and cardiovascular health. (hammernutrition.com)

The translational value for cardiac transplantation of this prospective multi-centre clinical study of vasodilation in amyloidosis remains to be evaluated. (ctsnet.org)
Collectively, our data demonstrate that brimonidine at clinical doses evokes a consistent NO-dependent vasodilation in first-order retinal arterioles but a heterogeneous response in second-order arterioles. (tamu.edu)

The term "vasodilation" refers to a widening of the blood vessels within the body. (medicalnewstoday.com)
Vasodilation refers to the widening of the arteries and large blood vessels. (medicalnewstoday.com)
Equidren - scientific name Boldenodrol - is a highly specialized combination of natural compounds designed to increase anabolic effects through enhanced vasodilation or 'blood pumping effect' in blood vessels. (iamtamj.com)

However, vasodilation can also contribute to certain health conditions, such as low blood pressure and several chronic inflammatory conditions. (medicalnewstoday.com)
Vasodilation therefore creates a natural drop in blood pressure. (medicalnewstoday.com)
A secondary deficiency of 6R-BH4 disrupts NO production, resulting in loss of vasodilation control and increased blood pressure. (pharmiweb.com)

Endothelial-dependent vasodilation is impaired in patients with systemic sclerosis, as assessed by low dose iontophoresis. (lancs.ac.uk)

La ingesta de L-arginina por vía oral o intravenosa durante un máximo de 8 semanas aumenta el flujo sanguíneo en personas con esta afección. (medlineplus.gov)

This way, it is responsible for improving exercise efficiency and tolerance, along with improvement in vasodilation. (fastandup.in)

abstract = "The influence of dehydration on hindlimb vasodilation during environmental heating (EH) was examined in eight unanesthetized chronically instrumented baboons. (uthscsa.edu)

There are several factors that can affect vasodilation. (medicalnewstoday.com)
vasodilation produced by the NO horns in the rear of theprotective factorsthis job you separately for subjects with type 1 and typeare risk factors for the DE. (dmn.ca)

Keep reading for more information on the effects of vasodilation on the body. (medicalnewstoday.com)

The skin's ability to blanch can be helpful in diagnosing rashes and other inflammatory conditions like sunburns, which are caused by vasodilation (dilation) in capillaries throughout the body. (aajkaakhbaar.com)

Neuroleptic drugs also predispose a person to hypothermia by inducing vasodilation and suppressing the shivering response. (cdc.gov)

The duration of the vasodilation induced by zaprinast inhalation was greater than that induced by NO inhalation. (asahq.org)

Anatomy35

Organisms9

Diseases13

Chemicals and Drugs109

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology1

Phenomena and Processes37

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science1

Health Care5

Phospholamban is present in endothelial cells and modulates endothelium-dependent relaxation. Evidence from phospholamban gene-ablated mice. (1/8444)

Loss of endothelium and receptor-mediated dilation in pial arterioles of rats fed a short-term high salt diet. (2/8444)

Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. (3/8444)

Role of endothelin in the increased vascular tone of patients with essential hypertension. (4/8444)

Microvascular function relates to insulin sensitivity and blood pressure in normal subjects. (5/8444)

Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation. (6/8444)

Neurogenic vasodilatation of canine isolated small labial arteries. (7/8444)

Relaxation of endothelin-1-induced pulmonary arterial constriction by niflumic acid and NPPB: mechanism(s) independent of chloride channel block. (8/8444)

Vasodilation

Vasodilator Agents

Forearm

Nitric Oxide

Arterioles

Nitroprusside

Endothelium, Vascular

Regional Blood Flow

Acetylcholine

Brachial Artery

Vascular Resistance

omega-N-Methylarginine

Hyperemia

Nitroglycerin

Nitric Oxide Synthase

Coronary Circulation

Coronary Vessels

Vasoconstriction

NG-Nitroarginine Methyl Ester

Blood Flow Velocity

Blood Pressure

Laser-Doppler Flowmetry

Adenosine

Vasomotor System

Microcirculation

Endothelium-Dependent Relaxing Factors

Hemodynamics

Enzyme Inhibitors

Mesenteric Arteries

Nitric Oxide Synthase Type III

Dogs

Nitroarginine

Bradykinin

Dose-Response Relationship, Drug

Vasoconstrictor Agents

Indomethacin

Plethysmography

Pia Mater

Biological Factors

Infusions, Intra-Arterial

Arginine

Cyclooxygenase Inhibitors

Skin

Pulmonary Circulation

Rats, Sprague-Dawley

Bretylium Tosylate

Nitric Oxide Donors

Muscle, Smooth, Vascular

Arteries

Heart Rate

Potassium Channel Blockers

Papaverine

Sweating

Cerebral Arteries

Skin Temperature

Glyburide

Anoxia

Myography

Potassium Channels

Renal Circulation

Calcitonin Gene-Related Peptide

Body Temperature Regulation

Isosorbide Dinitrate

Cerebrovascular Circulation

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

Prostaglandins

Cyclic GMP

Flushing

Blood Vessels

Swine

Guanylate Cyclase

Purinergic P1 Receptor Antagonists

Phenylephrine

Pulmonary Artery

Norepinephrine

Hypertension

Potassium Chloride

Retinal Artery

Rats, Wistar

Nitrites