The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
The circulation of the BLOOD through the LUNGS.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
The flow of BLOOD through or around an organ or region of the body.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Simultaneous resistance to several structurally and functionally distinct drugs.
The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.
Part of the arm in humans and primates extending from the ELBOW to the WRIST.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The circulation of the BLOOD through the vessels of the KIDNEY.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Drugs used to cause dilation of the blood vessels.
Substances that reduce the growth or reproduction of BACTERIA.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
The circulation of blood through the BLOOD VESSELS supplying the abdominal VISCERA.
Treatment process involving the injection of fluid into an organ or tissue.
Nonsusceptibility of bacteria to the action of TETRACYCLINE which inhibits aminoacyl-tRNA binding to the 30S ribosomal subunit during protein synthesis.
The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Elements of limited time intervals, contributing to particular results or situations.
Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
Drugs used to cause constriction of the blood vessels.
External decompression applied to the lower body. It is used to study orthostatic intolerance and the effects of gravitation and acceleration, to produce simulated hemorrhage in physiologic research, to assess cardiovascular function, and to reduce abdominal stress during childbirth.
Relatively complete absence of oxygen in one or more tissues.
The circulation of blood through the CORONARY VESSELS of the HEART.
Diseases of plants.
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
Nonsusceptibility of an organism to the action of penicillins.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Recording of change in the size of a part as modified by the circulation in it.
The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.
The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
The vessels carrying blood away from the heart.
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The vascular resistance to the flow of BLOOD through the CAPILLARIES portions of the peripheral vascular bed.
The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body.
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Measurement of oxygen and carbon dioxide in the blood.
Proteins found in any species of bacterium.
A type of strength-building exercise program that requires the body muscle to exert a force against some form of resistance, such as weight, stretch bands, water, or immovable objects. Resistance exercise is a combination of static and dynamic contractions involving shortening and lengthening of skeletal muscles.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
Placement of a balloon-tipped catheter into the pulmonary artery through the antecubital, subclavian, and sometimes the femoral vein. It is used to measure pulmonary artery pressure and pulmonary artery wedge pressure which reflects left atrial pressure and left ventricular end-diastolic pressure. The catheter is threaded into the right atrium, the balloon is inflated and the catheter follows the blood flow through the tricuspid valve into the right ventricle and out into the pulmonary artery.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
The blood pressure in the ARTERIES. It is commonly measured with a SPHYGMOMANOMETER on the upper arm which represents the arterial pressure in the BRACHIAL ARTERY.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.
Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The inferior part of the lower extremity between the KNEE and the ANKLE.
An essential amino acid that is physiologically active in the L-form.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Distensibility measure of a chamber such as the lungs (LUNG COMPLIANCE) or bladder. Compliance is expressed as a change in volume per unit change in pressure.
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
The hollow, muscular organ that maintains the circulation of the blood.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
This amino acid is formed during the urea cycle from citrulline, aspartate and ATP. This reaction is catalyzed by argininosuccinic acid synthetase.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
A subtype of endothelin receptor found predominantly in the VASCULAR SMOOTH MUSCLE. It has a high affinity for ENDOTHELIN-1 and ENDOTHELIN-2.
Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Nonsusceptibility of a microbe to the action of ampicillin, a penicillin derivative that interferes with cell wall synthesis.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
The smallest divisions of the arteries located between the muscular arteries and the capillaries.
Nonsusceptibility of bacteria to the action of CHLORAMPHENICOL, a potent inhibitor of protein synthesis in the 50S ribosomal subunit where amino acids are added to nascent bacterial polypeptides.
A state of elevated cardiac output due to conditions of either increased hemodynamic demand or reduced cardiac oxygen output. These conditions may include ANEMIA; ARTERIOVENOUS FISTULA; THYROTOXICOSIS; PREGNANCY; EXERCISE; FEVER; and ANOXIA. In time, compensatory changes of the heart can lead to pathological form of high cardiac output and eventual HEART FAILURE.
21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
The circulation of BLOOD through the LIVER.
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.
The circulation of BLOOD, of both the mother and the FETUS, through the PLACENTA.
A type of impedance plethysmography in which bioelectrical impedance is measured between electrodes positioned around the neck and around the lower thorax. It is used principally to calculate stroke volume and cardiac volume, but it is also related to myocardial contractility, thoracic fluid content, and circulation to the extremities.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
A competitive inhibitor of nitric oxide synthetase.
Processes and properties of the CARDIOVASCULAR SYSTEM as a whole or of any of its parts.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
The blood pressure in the VEINS. It is usually measured to assess the filling PRESSURE to the HEART VENTRICLE.
An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The veins and arteries of the HEART.
Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
The functional hereditary units of BACTERIA.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)
Injections made into a vein for therapeutic or experimental purposes.
A standard and widely accepted diagnostic test used to identify patients who have a vasodepressive and/or cardioinhibitory response as a cause of syncope. (From Braunwald, Heart Disease, 7th ed)
Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
The measure of a BLOOD VESSEL's ability to increase the volume of BLOOD it holds without a large increase in BLOOD PRESSURE. The vascular capacitance is equal to the change in volume divided by the change in pressure.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The vessels carrying blood away from the capillary beds.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.
Hypertrophy and dilation of the RIGHT VENTRICLE of the heart that is caused by PULMONARY HYPERTENSION. This condition is often associated with pulmonary parenchymal or vascular diseases, such as CHRONIC OBSTRUCTIVE PULMONARY DISEASE and PULMONARY EMBOLISM.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Non-susceptibility of an organism to the action of the cephalosporins.
Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
The interruption or removal of any part of the vagus (10th cranial) nerve. Vagotomy may be performed for research or for therapeutic purposes.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A pumping mechanism that duplicates the output, rate, and blood pressure of the natural heart. It may replace the function of the entire heart or a portion of it, and may be an intracorporeal, extracorporeal, or paracorporeal heart. (Dorland, 28th ed)
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
Nonsusceptibility of bacteria to the antibiotic KANAMYCIN, which can bind to their 70S ribosomes and cause misreading of messenger RNA.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Diminished or failed response of PLANTS to HERBICIDES.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Nonsusceptibility of bacteria to the action of VANCOMYCIN, an inhibitor of cell wall synthesis.
The ability of viruses to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutation.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Inorganic salts of the hypothetical acid, H3Fe(CN)6.
A cell line derived from cultured tumor cells.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The position or attitude of the body.
The hemodynamic and electrophysiological action of the right HEART VENTRICLE.
Delivery of drugs into an artery.
A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A direct-acting vasodilator that is used as an antihypertensive agent.
The nonstriated involuntary muscle tissue of blood vessels.
Glucose in blood.
Condition of low SYSTEMIC VASCULAR RESISTANCE that develops secondary to other conditions such as ANAPHYLAXIS; SEPSIS; SURGICAL SHOCK; and SEPTIC SHOCK. Vasoplegia that develops during or post surgery (e.g., CARDIOPULMONARY BYPASS) is called postoperative vasoplegic syndrome or vasoplegic syndrome.
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
The processes whereby the internal environment of an organism tends to remain balanced and stable.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)
A group of compounds that contain the structure SO2NH2.
An absence of warmth or heat or a temperature notably below an accustomed norm.

The effect of cardiac contraction on collateral resistance in the canine heart. (1/5462)

We determined whether the coronary collateral vessels develop an increased resistance to blood flow during systole as does the cognate vascular bed. Collateral resistance was estimated by measuring retrograde flow rate from a distal branch of the left anterior descending coronary artery while the main left coronary artery was perfused at a constant pressure. Retrograde flow rate was measured before and during vagal arrest. We found that in 10 dogs the prolonged diastole experienced when the heart was stopped caused no significant change in the retrograde flow rate, which indicated that systole has little effect on the collateral resistance. However, when left ventricular end-diastolic pressure was altered by changing afterload or contractility, a direct relationship between end-diastolic pressure and collateral resistance was noted.  (+info)

Site of myocardial infarction. A determinant of the cardiovascular changes induced in the cat by coronary occlusion. (2/5462)

The influence of site of acute myocardial infarction on heart rate, blood pressure, cardiac output, total peripheral resistance (TPR), cardiac rhythm, and mortality was determined in 58 anesthetized cats by occlusion of either the left anterior descending (LAD), left circumflex or right coronary artery. LAD occlusion resulted in immediate decrease in cardiac output, heart rate, and blood pressure, an increase in TPR, and cardiac rhythm changes including premature ventricular beats, ventricular tachycardia, and occasionally ventricular fibrillation. The decrease in cardiac output and increase in TPR persisted in the cats surviving a ventricular arrhythmia. In contrast, right coronary occlusion resulted in a considerably smaller decrease in cardiac output. TPR did not increase, atrioventricular condition disturbances were common, and sinus bradycardia and hypotension persisted in the cats recovering from an arrhythmia. Left circumflex ligation resulted in cardiovascular changes intermediate between those produced by occlusion of the LAD or the right coronary artery. Mortality was similar in each of the three groups. We studied the coronary artery anatomy in 12 cats. In 10, the blood supply to the sinus node was from the right coronary artery and in 2, from the left circumflex coronary artery. The atrioventricular node artery arose from the right in 9 cats, and from the left circumflex in 3. The right coronary artery was dominant in 9 cats and the left in 3. In conclusion, the site of experimental coronary occlusion in cats is a major determinant of the hemodynamic and cardiac rhythm changes occurring after acute myocardial infarction. The cardiovascular responses evoked by ligation are related in part to the anatomical distribution of the occluded artery.  (+info)

Effect of tumor necrosis factor alpha on vascular resistance, nitric oxide production, and glucose and oxygen consumption in perfused tissue-isolated human melanoma xenografts. (3/5462)

The effect of tumor necrosis factor alpha (TNF-alpha) on vascular resistance, nitric oxide production, and consumption of oxygen and glucose was examined in a perfused tissue-isolated tumor model in nude mice. One experimental group was perfused with heparinized Krebs-Henseleit buffer, a second one was perfused with TNF-alpha (500 microgram/kg) 5 h before perfusion. The vascular resistance increased significantly 5 h after TNF-alpha injection. The increase in vascular resistance did not seem to be mediated by a decrease in tumor nitric oxide production, as determined by perfusate nitrate/nitrite concentrations, but may be due to aggregation of leukocytes, platelets, and erythrocytes and/or endothelial consumption among the three experimental groups. The oxygen consumption was linearly dependent on the amount of available oxygen in the perfusate, whereas the glucose consumption was constant and independent of the glucose delivery rate. The present experiments provide new insights into physiological and metabolic mechanisms of action of TNF- alpha for optimization of future treatment schedules involving TNF-alpha.  (+info)

Trigeminal and carotid body inputs controlling vascular resistance in muscle during post-contraction hyperaemia in cats. (4/5462)

1. In anaesthetized cats, the effects of stimulation of the receptors in the nasal mucosa and carotid body chemoreceptors on vascular resistance in hindlimb skeletal muscle were studied to see whether the responses were the same in active as in resting muscle. The measurements of vascular resistance were taken, first, in resting muscle, and second, in the immediate post-contraction hyperaemic phase that followed a 30 s period of isometric contractions. 2. Stimulation of the receptors in the nasal mucosa caused reflex apnoea and vasoconstriction in muscle. The latter response was attenuated when the test was repeated during post-contraction hyperaemia. 3. Stimulations of the carotid bodies were made during a period of apnoea evoked reflexly by electrical stimulation of both superior laryngeal nerves. This apnoea prevented any effects of changes in respiration on the carotid body reflex vascular responses. Stimulation of the carotid bodies evoked hindlimb muscle vasoconstriction. In the post-contraction hyperaemic period, the response was reduced or abolished. A similar attenuation of the reflex vasoconstrictor responses occurred in decentralized muscles stimulated through their motor roots in the cauda equina. 4. Evidence is presented that the attenuation of the vasoconstrictor responses evoked by the two reflexes is a phenomenon localized to the contracting muscles themselves resulting from an interaction between sympathetic neuronal activity and the local production of metabolites. 5. The results are discussed in relation to the metabolic needs of tissues in relation to asphyxial defence mechanisms such as occur in the diving response.  (+info)

The cerebral haemodynamics of music perception. A transcranial Doppler sonography study. (5/5462)

The perception of music has been investigated by several neurophysiological and neuroimaging methods. Results from these studies suggest a right hemisphere dominance for non-musicians and a possible left hemisphere dominance for musicians. However, inconsistent results have been obtained, and not all variables have been controlled by the different methods. We performed a study with functional transcranial Doppler sonography (fTCD) of the middle cerebral artery to evaluate changes in cerebral blood flow velocity (CBFV) during different periods of music perception. Twenty-four healthy right-handed subjects were enrolled and examined during rest and during listening to periods of music with predominant language, rhythm and harmony content. The gender, musical experience and mode of listening of the subjects were chosen as independent factors; the type of music was included as the variable in repeated measurements. We observed a significant increase of CBFV in the right hemisphere in non-musicians during harmony perception but not during rhythm perception; this effect was more pronounced in females. Language perception was lateralized to the left hemisphere in all subject groups. Musicians showed increased CBFV values in the left hemisphere which were independent of the type of stimulus, and background listeners showed increased CBFV values during harmony perception in the right hemisphere which were independent of their musical experience. The time taken to reach the peak of CBFV was significantly longer in non-musicians when compared with musicians during rhythm and harmony perception. Pulse rates were significantly decreased in non-musicians during harmony perception, probably due to a specific relaxation effect in this subgroup. The resistance index did not show any significant differences, suggesting only regional changes of small resistance vessels but not of large arteries. Our fTCD study confirms previous findings of right hemisphere lateralization for harmony perception in non-musicians. In addition, we showed that this effect is more pronounced in female subjects and in background listeners and that the lateralization is delayed in non-musicians compared with musicians for the perception of rhythm and harmony stimuli. Our data suggest that musicians and non-musicians have different strategies to lateralize musical stimuli, with a delayed but marked right hemisphere lateralization during harmony perception in non-musicians and an attentive mode of listening contributing to a left hemisphere lateralization in musicians.  (+info)

Reversal of severe pulmonary hypertension with beta blockade in a patient with end stage left ventricular failure. (6/5462)

A 52 year old man with severe chronic left ventricular failure (New York Heart Association class IV) was considered unsuitable for cardiac transplantation because of high and irreversible pulmonary vascular resistance (PVR). In an attempt to produce symptomatic improvement, metoprolol was cautiously introduced, initially at 6.25 mg twice daily. This was slowly increased to 50 mg twice daily over a two month period and continued thereafter. After four months of treatment the patient's symptoms had improved dramatically. His exercise tolerance had increased and diuretic requirements reduced to frusemide 160 mg/day only. Assessment of right heart pressures was repeated and, other than a drop in resting heart rate, there was little change in his pulmonary artery pressure or PVR. His right heart pressures were reassessed showing a pronounced reduction in pulmonary artery pressure and a significant reduction in PVR, which fell further with inhaled oxygen and sublingual nitrates. He was then accepted onto the active waiting list for cardiac transplantation. A possible mechanism of action was investigated by assessing responses to beta agonists during treatment. Not only was there pronounced improvement in PVR but it was also demonstrated that beta receptor subtype cross-regulation may have contributed to the mechanism of benefit.  (+info)

Regulation of myocardial blood flow by oxygen consumption is maintained in the failing heart during exercise. (7/5462)

The hemodynamic abnormalities and neurohumoral activation that accompany congestive heart failure (CHF) might be expected to impair the increase in coronary blood flow that occurs during exercise. This study was performed to determine the effects of CHF on myocardial oxygen consumption and coronary blood flow during exercise. Coronary blood flow was measured in chronically instrumented dogs at rest, during 2 stages of graded treadmill exercise under control conditions (n=10), and after the development of CHF produced by 3 weeks of rapid ventricular pacing (n=9). In the normal dogs, coronary blood flow increased during exercise in proportion to the increase in the heart rate x the left ventricular systolic blood pressure product (RPP). After the development of CHF, resting myocardial blood flow was 25% lower than normal (P<0.05). Myocardial blood flow increased during the first stage of exercise, but then failed to increase further during the second stage of exercise despite an additional increase in the RPP. Myocardial oxygen consumption during exercise was significantly lower in animals with CHF and paralleled coronary flow. Despite the lower values for coronary blood flow in animals with CHF, there was no evidence for myocardial ischemia. Thus, even during the second level of exercise when coronary flow failed to increase, myocardial lactate consumption continued and coronary venous pH did not fall. In addition, the failure of coronary flow to increase as the exercise level was increased from stage 1 to stage 2 was not associated with a further increase in myocardial oxygen extraction. Thus, cardiac failure was associated with decreased myocardial oxygen consumption and failure of oxygen consumption to increase with an increase in the level of exercise. This abnormality did not appear to result from inadequate oxygen availability, but more likely represented a reduction of myocardial oxygen usage with a secondary decrease in metabolic coronary vasodilation.  (+info)

Modulation of temperature-induced tone by vasoconstrictor agents. (8/5462)

One of the primary cardiovascular adjustments to hyperthermia is a sympathetically mediated increase in vascular resistance in the viscera. Nonneural factors such as a change in vascular tone or reactivity may also contribute to this response. Therefore, the aim of this study was to determine whether vascular smooth muscle tone is altered during heating to physiologically relevant temperatures >37 degrees C. Gradually increasing bath temperature from 37 degrees C (normothermia) to 43 degrees C (severe hyperthermia) produced graded contractions in vascular ring segments from rat mesenteric arteries and thoracic aortae. In untreated rings these contractions were relatively small, whereas hyperthermia elicited near-maximal increases in tension when rings were constricted with phenylephrine or KCl before heating. In phenylephrine-treated mesenteric arterial rings, the contractile responses to heating were markedly attenuated by the Ca2+ channel antagonists nifedipine and diltiazem. Diltiazem also blocked the contractile responses to heating in thoracic aortic rings. These results demonstrate that hyperthermia has a limited effect on tension generation in rat vascular smooth muscle in the absence of vascular tone. However, in the presence of agonist-induced tone, tension generation during heating is markedly enhanced and dependent on extracellular Ca2+. In conclusion, these data suggest that local regulation of vascular tone can contribute to the hemodynamic adjustments to hyperthermia.  (+info)

Title:Impact of Cardiovascular Factors on Pulse Wave Velocity and Total Vascular Resistance in Different Age Group Patients with Cardiovascular Disorders. VOLUME: 11 ISSUE: 4. Author(s):Amit Ghosh*, Abhijith Dharmarajan, Prafulla K. Swain, Debasish Das, Poonam Verma and Prabhas R. Tripathy. Affiliation:Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, Sijua, Patrapada, Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, Sijua, Patrapada, Department of Statistics, Utkal University, Department of Cardiology, All India Institute of Medical Sciences, Bhubaneswar, Sijua, Patrapada, Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, Sijua, Patrapada, Department of Anatomy, All India Institute of Medical Sciences, Bhubaneswar, Sijua, Patrapada. Keywords:Cardiovascular factors, hypertension, pulse wave velocity, total vascular resistance, BSA, BMI.. Abstract:. Background: Pulse Wave Velocity (PWV) is the propagation ...
Definition of Pulmonary vascular resistance in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Pulmonary vascular resistance? Meaning of Pulmonary vascular resistance as a finance term. What does Pulmonary vascular resistance mean in finance?
TY - JOUR. T1 - Relationship of cardiac allograft size and pulmonary vascular resistance to long-term cardiopulmonary function. AU - Yeoh, T. K.. AU - Frist, W. H.. AU - Lagerstrom, C.. AU - Kasper, E. K.. AU - Groves, J.. AU - Merrill, W.. PY - 1992/12/1. Y1 - 1992/12/1. N2 - The purpose of this study was to evaluate the long-term cardiopulmonary function of heart transplant patients who received disproportionately sized allografts for varying levels of pulmonary vascular resistance. Resting hemodynamics and oxygen uptake during exercise were recorded at 1 year after transplantation in 52 patients. No differences in resting heart rate, cardiac output, stroke volume, peak oxygen uptake during exercise, and exercise duration were found in recipients of undersized hearts (donor:recipient weight ratio [D:R] ,0.75), sized-matched hearts [D:R = 0.75 to 1.25), and oversized (D:R ,1.25) hearts. In a further analysis according to preoperative pulmonary vascular resistance, resting cardiac output ...
It has been shown that sustained insulin infusion causes an increase in sympathetic vasoconstrictor discharge but, despite this, also causes peripheral vasodilatation. The present study was designed to determine in healthy subjects the effect of ingestion of a carbohydrate meal, with its attendant physiological insulinaemia, on vascular resistance in and sympathetic vasoconstrictor discharge to the same vascular bed, and the relationship between these parameters. Fifteen healthy subjects were studied for 2 h following ingestion of a carbohydrate meal. Calf vascular resistance was measured by venous occlusion plethysmography, and muscle sympathetic nerve activity was assessed by peroneal microneurography. Five of the subjects also ingested water on a separate occasion, as a control. Following the carbohydrate meal, the serum insulin concentration increased to 588+/-72 pmol/l. This was associated with a 47% increase in skeletal muscle blood flow (P|0.001), a 39% fall in vascular resistance (P|0.001) and a
TY - JOUR. T1 - Progressive myocardial dysfunction associated with increased vascular resistance.. AU - Franciosa, J. A.. AU - Heckel, R.. AU - Limas, C.. AU - Cohn, J. N.. PY - 1980/10. Y1 - 1980/10. N2 - To study heart failure from a myocardial lesion, we injected glass beads into the circumflex coronary artery of 11 conscious dogs and followed hemodynamics for 10 mo. Heart rate remained unchanged. Control mean arterial pressure of 112.3 +/- 3.0 (SE) mmHg was unchanged at 1 and 3 mo, but rose to 127.2 +/- 8.5 to 84.0 +/- 7.6 ml . kg-1 . min-1 at 10 mo (P , 0.02), but was unchanged at 1 and 3 mo. Left ventricular end-diastolic pressure (LVEDP) averaged 4.6 +/- 0.8 mmHg at control and rose to 11.8 +/- 1.4 mmHg at 1 mo and 14.9 +/- 2.5 mmHg at 10 mo (both P , 0.01). Systemic vascular resistance rose significantly by 10 mo. The ratio of stroke work to LVEDP fell from 13.1 +/- 0.1 at control to 3.8 +/- 0.5 by 10 mo (P , 0.01). In this dog model, left ventricular dysfunction is manifest early by ...
The calculator Pulmonary Vascular Resistance is used in the management of patients with cardiovascular and pulmonary disease. The parameters used in the calculation include mean pulmonary artery pressure, left arterial pressure, and pulmonary flow.
BioAssay record AID 232387 submitted by ChEMBL: Ratio of ED20 of MABP (mean arterial blood pressure) to the ED15 of RVR ( renal vascular resistance)..
Fingerprint Dive into the research topics of Etiologic factors and sites of origin of pulmonary vascular resistance hysteresis. Together they form a unique fingerprint. ...
CI=confidence interval; PVRI=pulmonary vascular resistance index; PAP=pulmonary artery pressure; STARTS-1=Sildenafil in Treatment-Naïve Children, Aged 1 to ...
The SVRI Forum prize-giving is an important part of every SVRI Forum. By awarding prizes to presentations and posters, the SVRI aims to encourage and support quality research. SVRI Forum Awards 2019 SVRI Forum Awards 2017 SVRI Forum Awards 2015 SVRI Forum Awards 2013
Baseline and surgery characteristics were not different between groups. The mean age of patients was 66 years (SD 8) vs. 68(6), respectively. Mean duration of CPB was 105 minutes (SD 24) vs. 108(28). Weighted PaO2 during CPB was 220 mmHg, IQR (211-233) vs. 157 (151-162, P, 0.0001), respectively. In the ICU, weighted PaO2 was 107 (86-141) vs. 90 (84-98, P = 0.03). Median maximum values of CK-MB were 25.8µg/L, IQR (20.3-32.6) vs. 24.9 (18.0-31.2, P = 0.5) and of Troponin-T 0.35 µg/L, IQR (0.30-0.46) vs. 0.42(0.26-0.49, P = 0.9). Areas under the curve (AUC) of CK-MB (Figure 1) were median 23.5 µg/L/h, IQR (18.4-28.1) vs. 21.5(15.8-26.6, P = .35) and 0.30µg/L/h (0.25-0.44) vs. 0.39 (0.24-0.43, P = .81) for Troponin-T. Cardiac Index, Systemic Vascular Resistance Index, and serum lactate levels (Lactatemax median 2 mmol/L IQR(1.4-2.6) vs. 2.2(1.7-2.6, P = .52)) were similar between groups throughout the ICU period. ...
The primary end point is a composite variable (incidence rate of any events) consisting of death, failing Fontan or failed Fontan according to high pulmonary vascular resistance within the first 48 hours after receiving study drug ...
Prevention and management of low diastolic blood pressureTry to keep your salt intake to between 1.5 and 4 grams per day.. …. Eat a heart-healthy diet.. …. Drink enough fluids and avoid alcohol, which can increase your risk for dehydration.Stay physically active and start an exercise program.. …. Maintain a healthy weight.More items…•.. ...
總周邊血管阻力(Total Peripheral Resistance,TPR)可由下列數學公式表示:. R = ΔP/Q[2]. R 代表 TPR。 ΔP 代表全身體循環起終點的血壓變化量。 Q 代表心輸出量. 因此此公式可以解釋為. 總周邊血管阻力 = (平均動脈壓 - 平均靜脈壓)/ 心輸出量. 因此平均動脈壓可以下列公式定義:[3]. ...
DESCRIPTION The Indoor Bike Trainer is designed for people who want a ride anytime. Progressive fluid resistance unit for a consistent ...
TY - JOUR. T1 - Contribution of perfusion pressure to vascular resistance response during head-up tilt. AU - Imadojemu, Virginia A.. AU - Lott, Mary E.J.. AU - Gleeson, Kevin. AU - Hogeman, Cynthia S.. AU - Ray, Chester A.. AU - Sinoway, Lawrence. N1 - Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2001. Y1 - 2001. N2 - We measured brachial and femoral artery flow velocity in eight subjects and peroneal and median muscle sympathetic nerve activity (MSNA) in five subjects during tilt testing to 40°. Tilt caused similar increases in MSNA in the peroneal and median nerves. Tilt caused a fall in femoral artery flow velocity, whereas no changes in flow velocity were seen in the brachial artery. Moreover, with tilt, the increase in the vascular resistance employed (blood pressure/flow velocity) was greater and more sustained in the leg than in the arm. The ratio of the percent increase in vascular resistance in leg to arm was 2.5:1. We suggest that the greater vascular resistance ...
TY - JOUR. T1 - The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca2+ release in rat mesenteric artery endothelial cells. AU - Alsuleimani, Y. M.. AU - Hiley, C. R.. PY - 2015/6/1. Y1 - 2015/6/1. N2 - Background and Purpose Lysophosphatidylinositol (LPI), a lipid signalling molecule, activates GPR55 and elevates intracellular Ca2+. Here, we examine the actions of LPI in the rat resistance mesenteric artery and Ca2+ responses in endothelial cells isolated from the artery. Experimental Approach Vascular responses were studied using wire myographs. Single-cell fluorescence imaging was performed using a MetaFluor system. Hypotensive effects of LPI were assessed using a Biopac system. Key Results In isolated arteries, LPI-induced vasorelaxation was concentration- and endothelium-dependent and inhibited by CID 16020046, a GPR55 antagonist. The CB1 receptor antagonist AM 251 had no effect, whereas rimonabant and O-1918 significantly potentiated LPI ...
1. In order to examine the effects of experimental hypertension on intracellular pH in mesenteric resistance arteries, intracellular pH was measured in mesenteric resistance arteries from rats with coarctation 72 h, 9 days and 28 days after the aorta was partially constricted between the origins of the renal arteries. Carotid arterial pressure was significantly raised at all time points.. 2. Second-order mesenteric resistance arteries were mounted in a myograph and were loaded with the acetoxymethyl ester of the pH-sensitive dye 2′,7′-bis(carboxyethyl)-5,6-carboxyfluorescein. Morphological measurements demonstrated that arteries from rats with coarctation had an increased media volume at 9 days and at 28 days compared with vessels from sham-operated control animals, but this was only statistically significant at 28 days.. 3. Resting intracellular pH was not significantly different at any time point in arteries from rats with coarctation compared with control animals, although there was a ...
Chronic hypoxia causes pulmonary hypertension associated with structural alterations in pulmonary vessels and sustained vasoconstriction. The transcriptional mechanisms responsible for these distinctive changes are unclear. We have previously reported that CREB1 is activated in the lung in response to alveolar hypoxia but not in other organs. To directly investigate the role of α and Δ isoforms of CREB1 in the regulation of pulmonary vascular resistance we examined the responses of mice in which these isoforms of CREB1 had been inactivated by gene mutation, leaving only the β isoform intact (CREBαΔ mice). Here we report that expression of CREB regulated genes was altered in the lungs of CREBαΔ mice. CREBαΔ mice had greater pulmonary vascular resistance than wild types, both basally in normoxia and following exposure to hypoxic conditions for three weeks. There was no difference in rho kinase mediated vasoconstriction between CREBαΔ and wild type mice. Stereological analysis of pulmonary
1. Serial pulmonary haemodynamic investigations were performed in 13 women before conception, at monthly intervals throughout pregnancy, and then at 6 months after delivery.. 2. Mean pulmonary artery pressure was calculated from pulsed Doppler pulmonary velocities. Pulmonary flow was measured by Doppler and cross-sectional echocardiography. These two measurements were used to calculate pulmonary vascular resistance.. 3. Mean non-pregnant pulmonary artery pressure was 13.8 mmHg and no significant change was demonstrated during pregnancy.. 4. Pulmonary flow increased from 4.88 to 7.19 litres/min during pregnancy.. 5. Pulmonary vascular resistance decreased from 2.85 resistance units before pregnancy to 2.17 resistance units at 8 weeks gestation. Thereafter there was no further significant change, values returning to pre-pregnant levels by 6 months after delivery. ...
TY - CONF. T1 - SVR versus rate-independent vascular resistance why SVR is a false measurement of total peripheral resistance. AU - Woodford, Stephen. N1 - Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.. PY - 2011. Y1 - 2011. N2 - Poster presented at Poster Session 9 on 16 May 2011.. AB - Poster presented at Poster Session 9 on 16 May 2011.. M3 - Poster. ER - ...
Echocardiographic assessment of pulmonary vascular resistance in pulmonary arterial hypertension - up-to-the-minute news and headlines. 7thSpace is a online portal covering topics such as Family, Business, Entertainment, Headlines, Recipes and more. A place for the whole family featuring many different sections to chose from.
In rats with long-term or chronic renovascular hypertension, we found that neither the change in BP or CO nor the renal vasoconstriction evoked by acute inhibition of NO synthesis was diminished compared with rats with early-phase 2K1C hypertension. Contrary to what we expected, this suggests that NO still contributes significantly to maintaining vascular tone in chronic 2K1C hypertension and that prolonged hypertension is apparently not exacerbated by developing endothelial dysfunction with diminished NO production. We had hypothesized that this chronic phase of 2K1C hypertension would be characterized by the loss of endothelial function and, therefore, a diminished influence of NO on vascular resistance. On the basis our bioassay of hemodynamic responses to NO synthesis inhibition, neither systemic nor renal endothelial dysfunction are factors in these rats. We further propose that in the chronic phase, blocking the AT1 receptor would no longer have a profound effect on BP or renal perfusion ...
Simple formulas may remain within the text of the manuscript if they can be set on the line: The pulmonary vascular resistance index (PVRI) was calculated as follows: PVRI = (MPAP − PCWP)/CI, where MPAP indicates mean pulmonary artery pressure; PCWP, pulmonary capillary wedge pressure; and CI, cardiac index. Long or complicated formulas should be centered on a separate line. In either case, symbols and signs should be marked in detail. Such formulas may be handled either as copy or as prepared art, depending on the availability of special characters and use of software for equation preparation. For online publications, formulas that require more
Simple formulas may remain within the text of the manuscript if they can be set on the line: The pulmonary vascular resistance index (PVRI) was calculated as follows: PVRI = (MPAP − PCWP)/CI, where MPAP indicates mean pulmonary artery pressure; PCWP, pulmonary capillary wedge pressure; and CI, cardiac index. Long or complicated formulas should be centered on a separate line. In either case, symbols and signs should be marked in detail. Such formulas may be handled either as copy or as prepared art, depending on the availability of special characters and use of software for equation preparation. For online publications, formulas that require more
Bell, James Stephen, Adio, Aminat, Pitt, Andrew, Hayman, Lindsay, Thorn, Clare E., Shore, Angela C., Whatmore, Jacqueline and Winlove, C. Peter 2016 ...
TY - JOUR. T1 - Nature and distribution of vascular resistance in hypoxic pig lungs. AU - Rock, P.. AU - Patterson, G. A.. AU - Permutt, S.. AU - Sylvester, J. T.. PY - 1985. Y1 - 1985. N2 - We used the vascular occlusion technique in pig lungs isolated in situ to describe the efffects of hypoxia on the distribution of vascular resistance and to determine whether the resistive elements defined by this technique behaved as ohmic or Starling resistors during changes in flow at constant outflow pressure, changes in outflow pressure at constant flow, and reversal of flow. During normoxia, the largest pressure gradient occurred across the middle compliant region of the vasculature (ΔPm). The major effect of hypoxia was to increase ΔPm and the gradient across the relatively noncompliant arterial region (ΔPa). The gradient across the noncompliant venous region (ΔPv) changed only slightly, if at all. Both ΔPa and ΔPv increased with flow but ΔPm decreased. The pressure at the arterial end of the ...
Introduction: Systemic Vascular Resistance (SVR) is a measurement of resistance and impediment of the systemic vascular bed to blood flow. SVR is a frequently ...
Nitric oxide synthase and renin-angiotensin gene expression and NOS function in the postnatal renal resistance vasculature Article ...
Abstract: Objective. To assess the relationship between cortisol concentrations in the last trimester of pregnancy and systemic vascular resistance - SVR in childhood. Materials and methods. This study is part of a cohort involving 130 Brazilian pregnant women and their children, ages 5 to 7 years. Maternal cortisol was determined in saliva by an enzyme immunoassay utilizing the mean concentration of 9 samples of saliva (3 in each different day), collected at the same time, early in the morning. SVR was assessed by the HDI/PulseWave CR-2000 Cardiovascular Profiling System®. Socioeconomic and demographic characteristics and life style factors were determined by a questionnaire. The nutritional status of the women and children was assessed by the body mass index - BMI. The association between maternal cortisol and SVR in childhood was calculated by multivariate linear regression analysis. Results.There were statistically significant associations between maternal cortisol and SVR (p = 0.043) and ...
An apparatus and method for detecting myocardial ischemia in a subject monitors the systemic vascular resistance of the subject and detects the presence of myocardial ischemia when the systemic vascular resistance increases by at least sixty percent over a base line value. Particular apparatus describe providing a measurement corresponding to the systemic vascular resistance of the cardiovascular system. A particular invasive pressure measuring apparatus uses a flexible catheter tube insertable into the artery of the subject and a micro-manometer embedded into the outer face of the wall of the catheter tube. The outer face of the embedded micro-manometer is directly exposed to the blood in an artery and the inner face of the embedded micro-manometer is covered by the inner face of the catheter tube wall.
Objective: Studies of high-risk pediatric cardiac transplant recipients are lacking. The purpose of this study is to evaluate early posttransplant survival in high-risk pediatric. patients.. Methods: The United Network for Organ Sharing (UNOS) provided de-identified patient-level data. The study population included 3502 recipients aged less than 21 years who underwent transplantation from January 1, 1995, through December 31, 2005. Recipients were stratified on the basis of the presence or absence of high-risk criteria: pulmonary vascular resistance index greater than 6 Wood units/m(2) (n = 285, 8.1%), this website creatinine clearance less than 40 mL/min (308, 8.8%), hepatitis C positivity (33, 0.9%), donor/recipient weight ratio less than 0.7 (80, 2.3%), panel reactive antibody greater than 40% (235, 6.7%), retransplantation (235, 6.7%), and age less than 1 year old (840, 24.0%).. Results: Overall, 1575 (45.0%) patients met at least one high-risk criterion. Higher numbers of high-risk ...
Delić-Brkljačić, Diana and Galešić, Krešimir and Ivanac, Gordana and Manola, Šime and Pintarić, Hrvoje and Štambuk, Krešimir and Gaćina, Petar and Radeljić, Vjekoslav (2009) Influence of ATII blockers and calcium channel blockers on renal vascular resistance in patients with essential hypertension. Collegium Antropologicum, 33 (4). pp. 1129-38. ISSN 0350-6134 ...
Delić-Brkljačić, Diana and Galešić, Krešimir and Ivanac, Gordana and Manola, Šime and Pintarić, Hrvoje and Štambuk, Krešimir and Gaćina, Petar and Radeljić, Vjekoslav (2009) Influence of ATII blockers and calcium channel blockers on renal vascular resistance in patients with essential hypertension. Collegium Antropologicum, 33 (4). pp. 1129-38. ISSN 0350-6134 ...
Cardivas is a brand name for Carvedilol, which is a vasodilating non-selective beta-blocking agent with antioxidant properties. Carvedilol reduces the peripheral vascular resistance through...
The Center for One Health Research Department of Environment & Occupational Health Sciences School of Public Health University of Washington Box 357234 Seattle, WA, USA ...
RESULTS Compared with baseline values, GFR (171 ± 20 to 120 ± 15 mL/min/1.73 m2) and filtration fraction (FF, 0.24 ± 0.06 to 0.18 ± 0.03) declined in hyperfilterers (ANOVA P ≤ 0.033), and renal vascular resistance increased (0.0678 ± 0.0135 to 0.0783 ± 0.0121 mmHg/L/min, P = 0.017). GFR and FF did not change in normofiltering subjects. In contrast, the radial augmentation index decreased in hyperfiltering (1.2 ± 11.7 to −11.0 ± 7.8%) and normofiltering (14.3 ± 14.0 to 2.5 ± 14.6%) subjects (within-group changes, ANOVA P ≤ 0.030). The decline in circulating aldosterone levels was similar in both groups. ...
Clamping of the umbilical cord and expansion of the lungs at birth shift gas exchange from the placenta to the lungs. Removal of the placenta also causes an increase in systemic vascular resistance to about twice that before birth. ...
Cook Medical is releasing in the United States its TriForce Peripheral Crossing Set, devices made to support percutaneous wire guides while performing interventions within the peripheral vasculature. In addition to helping to directly treat obstructions, the devices can also be used to inject radiopaque angiography contrast media to image the vasculature being worked on. The devices come in ...
For many uses in chemistry or food production, for example, it is important to know whether measurement parameters such as pressure, temperature and resistance change. Sensors, regulators and switches can point to risks or nip these in the bud ...
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The application of cardiopulmonary bypass (CPB) using a heart-lung machine in open heart surgery is associated with numerous pathophysiological changes in the vascular system and the neurohormonal environment. In this study our purpose was to investigate whether the hormones brain natriuretic peptide (BNP) and ghrelin arc involved in changes in the systemic vascular resistance index (SVRI) after CPB, using data from 20 patients who had undergone coronary artery bypass grafting accompanied by CPB. Hemodynamic measurements were obtained using a thermodilution catheter and included cardiac index and systemic vascular resistance index. Blood samples were taken before CPB, after CPB, and at 0 and 24 h postoperatively. The blood levels of total and acylated ghrelin were quantified by radioimmunoassay. Blood levels of BNP were measured by a fluorescence immunoassay kit. The SVRI was significantly higher at the end of CPB and at 0 h postoperatively than before CPB (end of CPB: 4282 +/- 1035 dyne . s . ...
Our results demonstrate that in vitro blockade of ACE is insufficient to prevent the contraction of human subcutaneous resistance arteries to Ang I. Because our preliminary experiments showed that this response is completely blocked by losartan, we assume that contraction to Ang I represents the effect of Ang II generated locally and acting on the Ang II type I receptor. Thus, treatment with an ACEI appears to be unable to prevent conversion of Ang I to Ang II in human resistance arteries. In the rabbit, in contrast, ACEI administration fully prevented Ang I-induced contraction.. Because ACE is identical to kininase II, the enzyme responsible for the degradation of kinins, it has been suggested that potentiation of BK may be partly responsible for the actions of ACEI. Thus, plasma kinin concentrations are increased in humans by quinapril, and ACEI-induced coronary artery vasodilation in dogs and humans has been shown to be mediated by BK.16 17 18 We investigated the effect of enalaprilat on the ...
TY - JOUR. T1 - Assessing myogenic response and vasoactivity in resistance mesenteric arteries using pressure myography. AU - Jadeja, Ravirajsinh N.. AU - Rachakonda, Vikrant. AU - Bagi, Zsolt. AU - Khurana, Sandeep. PY - 2015/7/6. Y1 - 2015/7/6. N2 - Small resistance arteries constrict and dilate respectively in response to increased or decreased intraluminal pressure; this phenomenon known as myogenic response is a key regulator of local blood flow. In isobaric conditions small resistance arteries develop sustained constriction known as myogenic tone (MT), which is a major determinant of systemic vascular resistance (SVR). Hence, ex vivo pressurized preparations of small resistance arteries are major tools to study microvascular function in near-physiological states. To achieve this, a freshly isolated intact segment of a small resistance artery (diameter ~260 μm) is mounted onto two small glass cannulas and pressurized. These arterial preparations retain most in vivo characteristics and ...
Vasoconstriction in atherosclerotic human subcutaneous resistance arteries - Science Exchange Lets You Compare Quotes From Leading Service Providers.
Vasodilatation in ischaemic human subcutaneous resistance arteries - Science Exchange Lets You Compare Quotes From Leading Service Providers.
TY - JOUR. T1 - Effects of weight reduction on cellular cation metabolism and vascular resistance. AU - Jacobs, David B.. AU - Sowers, James R.. AU - Hmeidan, Ammar. AU - Niyogi, Tushar. AU - Simpson, Lori. AU - Standley, Paul R. PY - 1993. Y1 - 1993. N2 - The early stages of weight loss are associated with a reduction in blood pressure, and the mechanisms mediating this reduction remain unclear. Platelet free calcium levels, [Ca2+]i» have been reported to be elevated in essential hypertension and to decrease with pharmacological treatment of the hypertension. In the current study, 18 obese subjects had measurements of blood pressure, forearm blood flow, forearm vascular resistance, and both basal platelet [Ca2+]i and [Ca2+]i responses to vasopressin during 12 weeks on a very low calorie (3,360 kj, or 800 kcal) diet. Weight reduction was associated with reduction in mean arterial blood pressure at 3-4 weeks. There were associated reductions in forearm vascular resistance and platelet [Ca2+]i as ...
Selection of patients with congenital heart disease for surgical septation in biventricular repair or surgical palliation in functionally single ventricles requires low pulmonary vascular resistance (PVR). Where there is uncertainty, PVR can be assessed using hybrid cardiovascular magnetic resonance (CMR) and fluoroscopic (X-Ray) guided cardiac catheterizations (XMR). CMR/XMR catheterization is a validated technique for accurate assessment of pulmonary vascular resistance. However, data concerning its application in clinical practice is lacking. PVR assessments were performed in 167 studies in 149 congenital heart disease patients by CMR/XMR catheterization. Data was collated on patient demographics, procedural data, complications and outcomes. Institutional ethics approval was obtained. Median age was 3.6 years (6 days - 67 years) and weight 13.8 kg (2.3 -122 kg). One hundred and eight studies were in biventricular circulations and 59 in functionally single ventricles. Median radiation dose was 0.72
BACKGROUND Creatine kinase (CK) is a main predictor of blood pressure, and this is thought to largely depend on high resistance artery contractility. We previously reported an association between vascular contractility and CK in normotensive pregnancy, but pregnancy is a strong CK inducer, and data on human hypertension are lacking. Therefore, we further explored CK-dependency of vascular contractility outside the context of pregnancy in normotensive and hypertensive women. METHODS AND RESULTS Nineteen consecutive women, mean age 42 years (SE 1.3), mean systolic/diastolic blood pressure respectively 142.6 (SE 5.9)/85.6 (3.4) mm Hg (9 hypertensive), donated an omental fat sample during abdominal surgery. We compared vasodilation after the specific CK inhibitor 2,4-dinitro-1-fluorobenzene (DNFB; 10-6 mol/l) to sodium nitroprusside (10-6 mol/l) in isolated resistance arteries using a wire myograph. Additionally, we assessed predictors of vasoconstrictive force. DNFB reduced vascular contractility ...
Blood flow between these two vascular beds may not always be equal. If a state occurs in which pulmonary vascular resistance increases or systemic vascular resistance decreases blood will preferentially shift to the peripheral circulation at the expense of blood flow to the lungs. This is the pathophysiology behind the hypercyanotic spell (Tet spell) seen in children with tetralogy of Fallot and similar lesions. Increases in systemic vascular resistance or decreases in pulmonary vascular resistance will produce the opposite effect shunting blood to the pulmonary circulation at the expense of peripheral perfusion.. This may occur when a childs baseline state of hypoxic pulmonary hypertension is suddenly reversed with additional oxygen or assisted ventilations that decrease avelolar carbon dioxide concentrations.. In the patient presented, a univentricular heart distributed blood to both the pulmonary and systemic circulations. Dehydration and acidosis produced compensatory hyperventilation ...
To evaluate the effect of inhaled nebulized AIR001 administered according to 3 treatment arms (80 mg once daily, 46 mg 4 times daily, or 80 mg 4 times daily) in subjects with WHO Group 1 PAH for 16 weeks, as determined by time to the first morbidity/mortality event as defined in Time to Clinical Worsening (TTCW) assessments and change from Baseline to Week 16 in the following:. Pulmonary Vascular Resistance Index (PVRI), N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP), 6-Minute Walk Distance (6MWD) assessed at peak, 6MWD assessed prior to AIR001 nebulization (trough), Cardiac Output (CO), Cardiac Index (CI), Mean Right Atrial Pressure (mRAP), WHO/NYHA Functional Class (FC), Quality of Life (QOL) as measured by Short-Form 36 (SF-36), Borg Dyspnea Index, Mean pulmonary artery pressure (mPAP), PVR measured at trough, PVR/systemic vascular resistance (SVR) ratio at trough and peak,. To evaluate the safety and tolerability of AIR001 in subjects with WHO Group 1 PAH. ...
TY - JOUR. T1 - Vascular Mechanisms of Post-exercise Blood Pressure Responses in Peripheral Artery Disease. AU - Correia, M A. AU - Soares, A H G. AU - Cucato, G G. AU - Lima, A H R. AU - Gomes, A P F. AU - Prazeres, T M P. AU - Rodrigues, S C. AU - Sobral-Filho, D. AU - Santos, A C. AU - Brasileiro-Santos, M S. AU - Ritti-Dias, R M. PY - 2015/11. Y1 - 2015/11. N2 - This study aimed to analyze the vascular mechanisms involved in post-resistance decreases in blood pressure in patients with peripheral artery disease. 17 patients underwent 2 experimental sessions conducted in random order: resistance exercise (REx-3×10 reps in 8 exercises with intensity of ~ 60% of 1 RM) and control (C- resting on the exercise machines for 50 min). Before and after each experimental session, blood pressure, reflected wave indicators, pulse wave velocity, blood flow, blood flow post-reactive hyperemia and peripheral vascular resistance responses were obtained. Both sessions increased brachial systolic, diastolic ...
TY - JOUR. T1 - Reductions in blood pressure after acute exercise by hypertensive rats. AU - Overton, J. M.. AU - Joyner, M. J.. AU - Tipton, C. M.. PY - 1988. Y1 - 1988. N2 - Postexercise reductions in blood pressure at rest have been reported for hypertensive subjects. To determine whether postexercise hypotension would occur in spontaneously hypertensive rats and to test the hypothesis that any reductions would result because of decreases in regional vascular resistances, hypertensive rats (n=19) were instrumented with indwelling arterial catheters and Doppler probes to measure regional blood flows from the iliac, superior mesenteric, and renal arteries. Data were collected from animals who performed a 20- and a 40-min treadmill test at between 60 and 70% of their maximum O2 uptake. When the animals ran for 20 min, there was a pre- to postexercise drop in mean arterial pressure (MAP) from 158±3.6 to 150±3.6 mmHg (P,0.05) which was recorded 30 min after the exercise had ceased. The pre- to ...
BACKGROUND: Hypertension in pregnancy is one of the causes of maternal morbidity and mortality is high in addition to cases of bleeding and infection. In Indonesia hypertension in pregnancy is the cause of 30-40% of perinatal deaths. Hemokonsentrasi state is related to blood viscosity and hematocrit is an important determinant of the blood viscosity. Blood viscosity and peripheral vascular resistance affect the blood flow resistance, which has increased in primary hypertension. Careful observation of the several indicators prediction of preeclampsia, such as hematocrit levels can prevent from unwanted circumstances. METHODS: This research is to design interventions penelitiaan pre test - post to determine the relationship between hematocrit levels in preeclampsia before and after childbirth. All data collected old and new patients were evaluated. Pre and post test data is performed using the t test (t-test) and the test data to find the relationship of hematocrit levels with the degree of ...
We tested a sample of two Chhabra medium pressure shunts (containing two balls) using a 2 week evaluation protocol.2 Our main aim was to investigate the impact of posture (horizontal-vertical) on shunt pressure-flow performance. We also investigated how the fluctuations in proximal pressure, simulating the presence of naturally occurring waves of intraventricular pressure, may alter shunt function. Such waves may occur not only due to heart and respiratory function but also due to body movements during walking, jogging, etc.. The figure (B) shows two typical pressure-flow performance curves recorded in the horizontal and the vertical position. They represent two almost straight parallel lines. Their slopes depict the low hydrodynamic resistance of the shunt (1.3 mm Hg/ml/min) This is much lower than the physiological resistance to CSF outflow, which normally lies within the range 6-10 mm Hg/ml/min.5 The average operating pressure determined for the vertical shunt position was around 7 mm Hg and ...
Objective:The present study aimed to compare circadian hemodynamic characteristics in hypertensive patients with and without primary aldosteronism.Methods:Circadian hemodynamics, including 24-h brachial and central blood pressure (BP), SBP variability indices, central pulse wave velocity (PWV), augm
Kutter, A P N (2013). Invasive and non-invasive measurement and importance of cardiac output and systemic vascular resistance in animals. In: 23rd ECVIM-CA Congress, Liverpool, Great Britain, 12 September 2013 - 14 September 2013. ...
Under normal conditions, blood flow in the renal arterial circulation is antegrade and maintained during diastole. When renal arterial vascular resistance increases or compliance lessens, a decrease in renal diastolic blood flow occurs, which is more pronounced than the decrease in the systolic component (11). This action results in an increased RI. Importantly, the Doppler waveform is altered not by vascular resistance alone but by the interaction of vascular resistance and compliance (e.g., large arterial distensibility, pulse pressure). Therefore, aging, atherosclerosis, and stiffening of the large arteries will result in an increased RI (12). This scenario likely explains the significantly lower baseline RI value in the cohort of healthy young subjects compared with HF patients.. Baseline levels of VII were not different between groups. After multivariate analyses, there was a poor but significant correlation between RVSP and baseline VII, but no significant correlation remained between ...
T. Komatsu, V. Kumar, V. Sanchala, K. Shibutani; SYSTEMIC VASCULAR RESISTANCE NEEDS CORRECTION FOR HEMATOCRIT VALUES. Anesthesiology 1982; 57:A124 doi: Download citation file:. ...
in Veterinary Research Communications (1992), 16(6), 453-464. The lungs of 13 healthy Landrace piglets were isolated, perfused and maintained in an isogravimetric state under zone III conditions. By applying vascular occlusion methods, the total blood flow ... [more ▼]. The lungs of 13 healthy Landrace piglets were isolated, perfused and maintained in an isogravimetric state under zone III conditions. By applying vascular occlusion methods, the total blood flow resistance (Rt) was partitioned into four components: arterial (Ra), pre- (Ra) and post-capillary (Rv), and venous (Rv). The capillary filtration coefficient (Kfc) was evaluated using a gravimetric technique. A bolus of 55 micrograms of Escherichia coli endotoxins (LPS) per 100 g of lung was injected into the arterial reservoir of eight lungs, followed by an infusion of LPS at a rate of 55 micrograms per 100 g of lung per hour for 180 min. A bolus of theophylline (85 mg per 100 g of lung weight) was injected into the arterial ...
Introduction: Some, but not all patients with advanced heart failure (HF) develop precapillary pulmonary hypertension (PH) due to unidentified mechanisms. We hypothesized that diminished local sensitivity to endogenous BNP, reflected by low rate of cGMP release, might be responsible for PH.. Methods: 18 patients with systolic HF and high pulmonary vascular resistance (PVR , 3 w.u. in euvolemia, PHHF) and 28 HF patients with low PVR (non-PHHF) of similar age, gender, body size and HF severity (52±12 years, 54% ischemic, NYHA 2,9±0,7, EF 23±4%) underwent right heart cath. Samples were obtained from pulmonary artery (PA) catheter before and during wedging (02sat.,95%) to calculate transpulmonary BNP uptake and cGMP release (concentration difference × CO). PHHF patients were re-measured 1 hour after oral dose of sildenafil (40mg).. Results: PHHF had similar systemic resistance (SVR), BNPPA (684 vs. 607 pg/ml, p=0.8) as non-PHHF, but higher PVR (6.4 vs. 1.9 w.u., p ,0.001), PA wedge pressure (26 ...
Coronary blood flow closely matches to metabolic demands of heart and myocardial oxygen consumption and is conditioned by function of coronary resistance vessels. The microvascular endothelium of coronary resistance vessels is exposed to a spatially
An arteriole is a blood vessel that extends and branches out from an artery and leads to capillaries. Arterioles have thick muscular walls and are the primary site of vascular resistance. The mean blood pressure in the arteries supplying the body is a result of the interaction between the cardiac output (the volume of blood the heart is pumping per minute) and the vascular resistance, usually termed total peripheral resistance by physicians and researchers. The up and down fluctuation of the arterial blood pressure is due to the pulsatile nature of the cardiac output and determined by the interaction of the stroke volume versus the volume and elasticity of the major arteries. Template:Anatomy-stub ...
Objective: We compared the renal and systemic vascular (renovascular) response to reducing bioavailable nitric oxide in patients with type 2 diabetes without nephropathy of African and Caucasian heritage.. Method: Under euglycaemic conditions, renal blood flow was measured by a constant infusion of paraminohippurate and changes in blood pressure and renal vascular resistance estimated before and after an infusion of L-Ng-monomethyl-l-arginine (L-NMMA).. Results: In the African heritage group there was a significant fall in renal blood flow (Δ − 46.0 mls/min/1.73 m2;p,0.05) and rise in systolic blood pressure (Δ10.0 [2.3 - 17.9] mmHg; p=0.017) which correlated with an increase in renal vascular resistance (r2=0.77; p=0.004).. Conclusions: The renal vasconstrictive response associated with nitric oxide synthase inhibition in this study may be of relevance to the observed vulnerability to renal injury in patients of African heritage.. ...
In the present study, vehicle-treated MI rats had depressed cardiac function that was characterized by reduced cardiac index and stroke volume index and increased systemic vascular resistance, indicating that heart failure developed in this animal model. Intravenous infusion of HGF, for 6 days beginning the day after ischemia/reperfusion, resulted in a significant improvement in cardiac performance, measured 8 weeks post-MI. Compared with rats with vehicle-treated MI, animals receiving HGF had significantly higher cardiac index and stroke volume index and reduced systemic vascular resistance. These three parameters were improved to near normal levels. To our knowledge, this is the first demonstration that HGF improves cardiac function in conscious animals with heart failure induced by MI.. The premise for this work was based on the observations that myocardial HGF and c-Met were induced for several days after MI (Ono et al., 1997;Ueda et al., 2001) and that the peak levels occurred well past the ...
How do we distinguish a difference between physiology 1 and physiology 2? The answer lies in the PAd - Ppao difference [3, 5]. In example 2 [e.g. WHO II pulmonary hypertension], the PAd - Ppao difference will remain small - the PAd and Ppao will rise together; the difference is normally less than 6 mmHg. In example 1 [e.g. WHO I pulmonary hypertension], the PAd rises much more than the Ppao.. Implications for Practice. It should be clear from the aforementioned, that it is not adequate to imply mechanisms from the cPVR alone, especially with respect to the pulmonary vascular tree. Noting an increase in the cPVR in response to an intervention should be followed with an inquiry into why the cPVR increased. Was it driven by a change in the pressure gradient [numerator] and if so, how? Did the PAd increase with respect to the Ppao [i.e. a true increase in resistance - thought experiment 1], or did the transpulmonary gradient rise solely because of increased PAs with preserved PAd-Ppao gradient [i.e. ...
Patients with precapillary PH and PVR who do meet the definition of PAH may have functional limitations and may benefit from therapy.
Results Overall, a discordance between IMR and MVO was observed in 36.7% of cases, with 31 patients having MVO and IMR ≤40. Compared with patients with MVO and IMR ≤40, patients with both MVO and IMR ,40 had an 11.9-fold increased risk of final IS ,25% at 6 months (p = 0.001). Patients with MVO and IMR ≤40 had a significantly smaller IS at 6 months (p = 0.001), with significant regression in IS over time (34.4% [interquartile range (IQR): 27.3% to 41.0%] vs. 22.3% [IQR: 16.0% to 30.0%]; p = 0.001). ...
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Eiger BioPharmaceuticals ubenimex failed to show improvement in pulmonary vascular resistance or exercise capacity in the Phase 2 LIBERTY clinical trial.
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Am heart j online levitra q buy 1986;60:2236. 5d and 3d ultrasound in obstetrics and gynecology. The majority of cases in the fetus because the suppression of the tachycardia has the best strategy. The same probably applies to patients and visitors comply with the t waves appear together: As mentioned, systemic vascular resistance, flow into the distal right-sided aortic arch with aberrant left pulmonary artery, which arises from the lack of increase in left atrial isom- erism, resulting in patient subsets. Magnetic resonance imaging techniques available is considered (e. The action potential is conducted (indicated with arrow). Neilson jp. In a patient with wpw. Arch dis child 1976;119:73861. Question 8. A patient with severe as with transposition will result in a changing level of the increased afterload and myocardial injury. Although several drugs with antineoplastic capabilities have been used to prevent expression of vegf expression showed similar defects and atrial flutter using ...
Just shake the Aerobar in a rhythmic pattern and feel it excite your core. Your abs, back, arms & shoulders will gain new levels of strength and stability - all in one easy workout. Its the perfect cardio tool to firm and tone your muscles. The resistance increases as you shake it harder. ...
Many people believe that one thing that happens to T2s is as insulin resistance increases the beta cells put out more insulin to compensate. that actu
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Flexible UltraSet circuit connectors from Smiths Medical are designed to minimize flow resistance while maintaining low dead space.
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... and vascular resistance is analogous to electrical resistance. The systemic vascular resistance can therefore be calculated in ... would also affect the measured vascular resistance.[citation needed] Pulmonary vascular resistance (PVR) also depends on the ... Vascular resistance is the resistance that must be overcome to push blood through the circulatory system and create flow. The ... There are many factors that alter the vascular resistance. Vascular compliance is determined by the muscle tone in the smooth ...
Pulmonary vascular resistance-PVR > 240 dynes s cm−5 . Pulmonary artery occlusion pressure- PAOP < 15mmHg or transpulmonary ... and pulmonary vascular resistance (PVR) without affecting systemic artery pressure because it is rapidly inactivated by ... Luo, B; Liu, L; Tang, L; Zhang, J; Stockard, CR; Grizzle, WE; Fallon, MB (May 2003). "Increased pulmonary vascular endothelin B ... A subset of patients does not respond to any therapy, likely having fixed vascular anatomic changes.[citation needed] ...
Vascular resistance Pulmonary shunt The pulmonary circulation is archaically known as the "lesser circulation" which is still ... Widrich, J; Shetty, M (March 2021). "Physiology, Pulmonary Vascular Resistance". StatPearls Publishing. PMID 32119267. "lesser ... Media related to Pulmonary circulation at Wikimedia Commons Official Journal of the Pulmonary Vascular Research Institute (CS1 ... Pulmonary hypertension describes an increase in resistance in the pulmonary arteries. Pulmonary embolism is occlusion or ...
Vasodilation Vasoconstriction Vascular resistance "CV Physiology , Local Regulation of Blood Flow". ... The sympathetic nervous system and a variety of hormones, for instance, both exert some degree of control over vascular tone. ... Acute local blood flow regulation refers to intrinsic regulation, or control, of arterial vascular tone at a local level, ... This intrinsic type of control means that the blood vessels can automatically adjust their own vascular tone, by dilating ( ...
Wu G, Meininger CJ (2009). "Nitric oxide and vascular insulin resistance". BioFactors. 35 (1): 21-7. doi:10.1002/biof.3. PMID ... March 2012). "Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with ... Channon KM (November 2004). "Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease". Trends ... with little benefit on vascular function. Depletion of tetrahydrobiopterin occurs in the hypoxic brain and leads to toxin ...
This reduces sympathetic tone to vascular smooth muscle. This reduces heart rate and vascular resistance. Digoxin increases ... which reach vascular smooth muscle. The vasomotor center changes vascular smooth muscle tone. This changes local and systemic ...
lycopersici, vascular wilt on tomato, is resistance. Other effective control methods are fumigating the infected soil and ... lycopersici causes vascular wilt in tomato. The disease starts out as yellowing and drooping on one side of the plant. Leaf ... Resistance analysis of cultivars and occurrence survey of Fusarium wilt on strawberry. Res. Plant Dis. 11: 35-38. Ploetz, Randy ... The most important of these is vascular wilt. Fusarium wilt starts out looking like vein clearing on the younger leaves and ...
This obstruction increases the pulmonary vascular resistance. If large enough, the clot increases the load on the right side of ... Low-voltage QRS complexes and electrical alternans are signs on EKG. However, EKG may not show these findings and most often ...
to cause a reduction in systemic vascular resistance. Fenoldopam has a rapid onset of action (4 minutes) and short duration of ...
This causes a fall in peripheral vascular resistance. Because blood pressure is directly proportional to peripheral vascular ... When the artery proximal to the fistula is compressed, blood is no longer shunted and the peripheral vascular resistance is ... Journal of Vascular Surgery. 26 (1): 171-172. doi:10.1016/S0741-5214(97)70168-X. ISSN 0741-5214. PMID 9240342. Ehtisham, ... resistance, in an AV fistula there is a fall in blood pressure and subsequent reflex tachycardia. ...
... systemic vascular resistance is mainly determined by the caliber of small arteries and arterioles. The resistance attributable ... Most influences on blood pressure can be understood in terms of their effect on cardiac output, systemic vascular resistance, ... Korner, P. I.; Angus, J. A. (1992). "Structural determinants of vascular resistance properties in hypertension. Haemodynamic ... Other physical factors that affect resistance include: vessel length (the longer the vessel, the higher the resistance), blood ...
The peripheral vascular resistance decreases when labetalol is first administered. Continuous labetalol use further decreases ... When labetalol is given in acute situations, it decreases the peripheral vascular resistance and systemic blood pressure while ... Labetalol acts by blocking alpha and beta adrenergic receptors, resulting in decreased peripheral vascular resistance without ... In short-term, acute situations, labetalol decreases blood pressure by decreasing systemic vascular resistance with little ...
Squatting leads to an increase in systemic vascular resistance. An increase in systemic vascular resistance results in an ...
Together, these forces will decrease the pulmonary vascular resistance. With decreased resistance in the lungs, there will be ... With a lack of oxygen entering the lungs, pulmonary vascular resistance will remain high and the newborn's blood will no longer ... At the pulmonary artery, it is met with high pulmonary vascular resistance as a result of collapsed lungs and pulmonary ... Lastly, due to the decreased pulmonary vascular resistance, the pressure of the pulmonary artery will fall until it is lower ...
Mulvany, MJ (1999). "Vascular remodelling of resistance vessels: can we define this?". Cardiovasc Res. 41 (1): 9-13. doi: ... structural changes of the vascular walls in hypertension and their relation to the control of the peripheral resistance". Acta ... Folkow's description of these vascular alterations has since been verified in a large number of studies. The role of the ... He described this mechanism as an essential element in vascular control. This is now well-established knowledge in ...
The ventricles must develop a certain tension to pump blood against the resistance of the vascular system. This tension is ... A decrease in normal vascular resistance can also occur. Different cardiac responses operate to restore homeostasis of the ... Since the electrical stimulus begins at the apex, the contraction also begins at the apex and travels toward the base of the ... The electrical event, the wave of depolarization, is the trigger for muscular contraction. The wave of depolarization begins in ...
These changes result in increased vascular resistance and PAH. Due to the potential anti-proliferative and anti-fibrotic ... Together, this causes vascular remodeling and narrowing of the pulmonary arteries. ... activity of terguride, this potential medicine could offer the hope of achieving reversal of pulmonary artery vascular ...
... or amyloidosis Vascular disease of the neck and leg arteries. High pulmonary vascular resistance - over 5 or 6 Wood units. ...
Vessel occlusion increases vascular resistance and therefore leads to hypertension. In portal hypertension, the vessels ... Diagram of the vascular channels in a human embryo of the second week. Human embryo with heart and anterior body-wall removed ... Wang, Y. Vascular biology of the placenta. in Colloquium Series on Integrated Systems Physiology: from Molecule to Function. ...
The RI is altered not by vascular resistance alone but by the combination of vascular resistance and vascular compliance. ... Boas FE, Desser TS, Kamaya A (2011). "Does separating the resistive index into pre- and post-glomerular resistance and vascular ... The formula used to calculate resistance index is: R I = v s y s t o l e − v d i a s t o l e v s y s t o l e {\displaystyle RI ... "Relationship between the resistive index and vascular compliance and resistance". Radiology. 211 (2): 411-7. doi:10.1148/ ...
Another way to find the MAP is to use the Systemic Vascular Resistance equated ( R {\displaystyle R} ), which is represented ... Blood pressure Hypertension Hypotension Systemic vascular resistance Pulse pressure Zheng L, Sun Z, Li J, et al. (July 2008). " ... MAP is altered by cardiac output and systemic vascular resistance. Mean arterial pressure can be measured directly or ... is systemic vascular resistance C V P {\displaystyle CVP} is central venous pressure and usually is small enough to be ...
It reduces mean arterial blood pressure by decreasing systemic vascular resistance. Clevidipine does not reduce cardiac filling ... Clevidipine is a dihydropyridine L-type calcium channel blocker, highly selective for vascular, as opposed to myocardial, ...
Subclavian steal syndrome Vascular resistance Arteriolar vasodilator Gould KL (August 1989). "Coronary steal. Is it clinically ... Thus, dilating the resistance vessels in the coronary circulation causes blood to be shunted away from the coronary vessels ...
Further, pulmonary vascular resistance usually drops back to close normal levels. Since the pulmonary resistance is ... Pulmonary vascular steal in chronic thromboembolic pulmonary hypertension. Olman MA, Auger WR, Fedullo PF, Moser KM. Chest. ... Resolution of vascular steal after pulmonary thromboendarterectomy. Moser KM, Metersky ML, Auger WR, Fedullo PF. Chest. 1993; ... of patients and is a result of changes in permeability to the vascular endothelium. Management of this condition may require ...
This is because they can decrease vascular resistance and decrease pressure. However, while these drugs are generally well ... Hypertension is due to an increase in vascular resistance and vasoconstriction. Using α1 selective antagonists, such as ... thus decreasing vascular resistance, increasing vasodilation, and decreasing blood pressure overall. Blockers that have both ... thus causing blood vessels to increase in vascular resistance, and ultimately giving rise to hypertension. In addition, ...
Hyperdynamic circulation, with peripheral vasodilatation from low systemic vascular resistance, leads to hypotension. There is ... Increased cardiac output and low systemic vascular resistance are characteristic of ALF. Pulmonary artery catheterization ...
This resistance was used to simulate TPR, or total peripheral (vascular) resistance. Starling resistors have been used both as ...
It is believed to lower peripheral vascular resistance in the long run. Two companies, Merck and Ciba, state they discovered ...
This inhibition leads to decreased peripheral vascular resistance and an antihypertensive effect. There is no reflex ...
"The effect of oxedrine on the left ventricle and peripheral vascular resistance". Arzneimittel-Forschung. 35 (12): 1844-6. PMID ... Broadley KJ (March 2010). "The vascular effects of trace amines and amphetamines". Pharmacology & Therapeutics. 125 (3): 363- ...
2005). "Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins". ... reductions in skeletal muscle NOX4 in aging and obesity was shown to contribute to the development of insulin resistance and ... 2004). "Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells". Arterioscler. Thromb. Vasc. Biol ... "Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase". Circ. Res. 110 (9): 1217-25. doi:10.1161/ ...
Vascular plants of Russia and adjacent states (the former USSR). Khassanov, F. O. & N. Rakhimova. 2012. Taxonomic revision of ... In May 2008, a study was carried out on the anatomical structure of the leaf and drought resistance of 4 different species of ... Wang, Jun; Gao, Yi-ke (May 2008). "Study on the Relationship between Leaf Anatomical Structure and Drought Resistance of Four ...
Zylbertal A, Kahan A, Ben-Shaul Y, Yarom Y, Wagner S (December 2015). "Prolonged Intracellular Na+ Dynamics Govern Electrical ... Lynch RM, Paul RJ (March 1987). "Compartmentation of carbohydrate metabolism in vascular smooth muscle". The American Journal ... Thus, some substitutions provide resistance to cardenolides as an adaptation even across phylogenetic branches. Thyroid hormone ...
... impaired biliary excretion of bilirubin glucuronide is due to a mutation in the canalicular multiple drug-resistance protein 2 ... its hydrophobicity and to limit the probability of unnecessary contact with other tissues and keep bilirubin in the vascular ... "Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced ...
Biopsy of the infected nasal tissue showed signs of necrosis and vascular invasion. Cunninghamella echinulata, like other ... members of the genus, exhibit strong resistance to the antifungal polyene, amphotericin B with a MIC (Minimum Inhibitory ...
In support of this notion, Gemigliptin, an anti-diabetic drug, has been shown reduce insulin resistance and concurrently ... LECT2 protein is widely expressed in vascular tissues, smooth muscle cells, adipocytes, cerebral neurons, apical squamous ... Meex RC, Watt MJ (2017). "Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance". Nature Reviews. ... and/or vascular areas of the kidney and b) the identification of these deposits as containing mainly LECT2 as identified by ...
... 's vasodilatory effects are thought to be due to the stimulation of the production of nitric oxide in the vascular ... which has been implicated in the development of insulin resistance. Because of its inhibitory effects on L-carnitine ... Reflecting or Inflicting Insulin Resistance?". Diabetes. 62 (1): 1-8. doi:10.2337/db12-0466. PMC 3526046. PMID 23258903. Lippi ...
Techniques in Vascular and Interventional Radiology. 19 (2): 163-168. doi:10.1053/j.tvir.2016.04.008. ISSN 1089-2516. PMID ... and the body can develop a resistance to them. Koyyalagunta, Dhanalakshmi; Burton, Allen W. (2010-08-01). "The Role of Chemical ...
Pulmonary artery pressure Pulmonary capillary wedge pressure Systemic vascular resistance Pulmonary vascular resistance Cardiac ... Vascular closure devices can be used to speed along hemostasis. Much equipment is required for a facility to perform the ...
Liu Z, Wang J, Mao Y, Zou B, Fan X (2016). "MicroRNA-101 suppresses migration and invasion via targeting vascular endothelial ... "Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma". Cancer Sci ...
Red Buttons, 87, American comedian, vascular disease. Pamela Cooper, 95, British refugee activist known for her work with the ... Rut Brandt, 86, Norwegian resistance fighter, second wife of former German chancellor Willy Brandt. Nigel Cox, 55, New Zealand ... Francis Cammaerts, 90, British Special Operations Executive (SOE) agent, led 30,000 French Resistance fighters. Dick Dickey, 79 ...
When primary or secondary resistance invariably develops, salvage therapy is considered. Allogeneic stem cell transplantation ... Vascular-related cutaneous conditions). ...
Electrical insulation paper: Cellulose is used in diverse forms as insulation in transformers, cables, and other electrical ... "Immunogold labeling of rosette terminal cellulose-synthesizing complexes in the vascular plant vigna angularis". The Plant Cell ... The mechanical role of cellulose fibers in the wood matrix responsible for its strong structural resistance, can somewhat be ...
... fatigue resistance, motor performance, and connective tissue integrity. In addition, there are cardiopulmonary and vascular ... Additionally, the resistance to fatigue was significantly decreased as well as the ability to sustain work and power output in ... This likely reflects use of these muscles during bed rest to adjust body position and to reduce the potential for vascular ... Akima, H; Kubo, K; Kanehisa, H; Suzuki, Y; Gunji, A; Fukunaga, T (May 2000). "Leg-press resistance training during 20 days of 6 ...
Leonardo studied the vascular system and drew a dissected heart in detail. He correctly worked out how heart valves ebb the ... Recalling this incident, Leonardo saw it as prophetic: An object offers as much resistance to the air as the air does to the ... a man with wings large enough and duly connected might learn to overcome the resistance of the air, and by conquering it, ...
Atherosclerotic plaque contains vascular smooth muscle cells, macrophages and endothelial cells and these have been found to ... "mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy". Proc. Natl. Acad. Sci. U.S.A. 111 (1): 409-14 ... Bautista-Niño PK, Portilla-Fernandez E, Vaughan DE, Danser AH, Roks AJ (2016). "DNA damage: a main determinant of vascular ... Wu H, Roks AJ (2014). "Genomic instability and vascular aging: a focus on nucleotide excision repair". Trends Cardiovasc. Med. ...
Loss of aqueous humor absorption leads to increased resistance and thus a chronic, painless buildup of pressure in the eye. In ... Vascular flow and neurodegenerative theories of glaucomatous optic neuropathy have prompted studies on various neuroprotective ... Simha A, Aziz K, Braganza A, Abraham L, Samuel P, Lindsley KB (February 2020). "Anti-vascular endothelial growth factor for ... rim appearance and vascular change. A formal visual field test is performed. The retinal nerve fiber layer can be assessed with ...
This self-care focuses on any acts which are healing and beneficial to one's survival and thereby enable resistance. This ... 2014). "The impact of financial barriers on access to care, quality of care and vascular morbidity among patients with diabetes ... and vascular disease. As a result, these patients have reduced rates of medical assessments, measurements of Hemoglobin A1C (a ... the preservation of her identity through acts that energize and sustain her is a form of activism and resistance. ...
... and resistance to chemical inactivation. Human-intestinal alkaline phosphatase. The human body has multiple types of alkaline ... into the increase of tumor necrosis factor-α and its direct effect on the expression of alkaline phosphatase in vascular smooth ... "Association between serum alkaline phosphatase and primary resistance to erythropoiesis stimulating agents in chronic kidney ...
Insulin resistance in critically ill patients with acute renal failure. Am J Physiol Renal Physiol, 289(2), F259-64, 2005 ... Epidemiology of vascular disease in renal failure. Blood Purif, 20(1), 6-10, 2002 Ikizler, TA, Morrow, JD, Roberts, LJ, Evanson ... Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients. Kidney ... Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease ...
Further, resistance to insects can reduce damage and disease severity. Genetic resistance to Diplodia stalk rot is highly ... In stalk infections, injury to the vascular system disrupts translocation and, thus, reduces grain size. S. maydis overwinters ... Flint cultivars are more resistant than dent, and resistance breeding offers promise for control, however complete resistance ( ... Some seed suppliers offer Diplodia rot resistance ratings for their hybrids. ...
This resistance to anti-mitogens might simply arise from overstimulation by positive mitogens. In other cases, tumor cells ... "Vascular Endothelial Growth Factor is a Secreted Angiogenic Mitogen". 8 December 1989, Science, Vol. 246, pp 1306-1309. Morgan ... Some growth factors, such as vascular endothelial growth factor, are also capable of directly acting as mitogens, causing ...
The vascular plant herbarium includes 90,000 specimens, of which 88,700 are leaves, and the rest fruits, seeds, and strobili. ... During World War I, due to passive resistance, the museum's collection were not moved to Russia. The Provincial Museum ...
A VEP is an electrical potential recorded after a subject is presented with a type of visual stimuli. There are several types ... researchers affiliated with University of Melbourne had begun developing a BCI that could be inserted via the vascular system. ... Institute of Electrical and Electronics Engineers (IEEE). 7 (1): 39-51. doi:10.1109/tamd.2014.2387271. ISSN 1943-0604. S2CID ... The electrode was tested on an electrical test bench and on human subjects in four modalities of EEG activity, namely: (1) ...
2003). "Vascular endothelial growth factor 121 and 165 in the subacromial bursa are involved in shoulder joint contracture in ... The patient performs an isometric flexion contraction against resistance of the therapist (Speed's Test). When the therapist's ... 2001). "Vascular endothelial growth factor (VEGF) expression in the subacromial bursa is increased in patients with impingement ... resistance is removed, a sudden jerking motion results and latent pain indicates a positive test for bursitis. Neer's Sign: If ...
December 2009). "Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells ... and Vascular Biology. 23 (8): 1322-1332. doi:10.1161/01.ATV.0000078520.89539.77. PMID 12763760. Nofer JR, Remaley AT (October ... and Vascular Biology. 23 (6): 965-971. doi:10.1161/01.ATV.0000055194.85073.FF. PMID 12615681. Singaraja RR, Brunham LR, ... and PKC pathways Overexpression of ABCA1 has been reported to induce resistance to the anti-inflammatory diarylheptanoid ...
April 2016). "A branched-chain amino acid metabolite drives vascular fatty acid transport and limits insulin resistance". ... Lynch CJ, Adams SH (December 2014). "Branched-chain amino acids in metabolic signalling and insulin resistance". Nature Reviews ... is associated with weight loss and decreased insulin resistance: higher levels of valine are observed in the blood of diabetic ...
While the reason for this phenomenon is unknown, there may be a genetic resistance to the cancers, a side effect of medications ... "ischemia-hypoxia regulation or vascular expression" even though only 3.5% of all genes were estimated to be involved in hypoxia ...
This is thought to be an epigenetic cause of T2DM by causing the body to develop an insulin resistance and inhibit the ... LSD1 may play a major role in diabetic retinopathy through the downregulation of Sod2 in retinal vascular tissue, leading to ... It is believed that much of the retinal vascular degeneration characteristic of diabetic retinopathy is due to impaired ... This leads to persistent vascular complications that can inhibit blood flow to limbs and the eyes. This persistent ...
Pulmonary Vascular Effects of Propofol at Baseline, during Elevated Vasomotor Tone, and in Response to Sympathetic α- and β- ... Increased Pulmonary Venous Resistance in Morbidly Obese Patients without Daytime Hypoxia: Clinical Utility of the Pulmonary ... PULMONARY VASCULAR RESISTANCE. Anesthesiology 1966; 27:882 doi: ... Pulmonary Vascular Effects of Isoflurane Anesthesia after Left Lung Autotransplantation in Chronically Instrumented Dogs ...
Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations. ... Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations. ...
Changes in regional vascular resistance and blood volume after hemorrhage in fed and fasted awake rats. / Darlington, D. N.; ... Changes in regional vascular resistance and blood volume after hemorrhage in fed and fasted awake rats. In: Journal of applied ... Changes in regional vascular resistance and blood volume after hemorrhage in fed and fasted awake rats. Journal of applied ... Darlington, D. N., Jones, R. O., Marzella, L., & Gann, D. S. (1995). Changes in regional vascular resistance and blood volume ...
... of antimicrobial resistance by means of phenotypic and genotypic tests in Staphylococcus aureus recovered from central vascular ...
Desferrioxamine elevates pulmonary vascular resistance in humans: potentital for involvement of HIF-1. In: Journal of Applied ... Desferrioxamine elevates pulmonary vascular resistance in humans: potentital for involvement of HIF-1. / Balanos, George; ... Desferrioxamine elevates pulmonary vascular resistance in humans: potentital for involvement of HIF-1. Journal of Applied ... 2002). Desferrioxamine elevates pulmonary vascular resistance in humans: potentital for involvement of HIF-1. Journal of ...
Echocardiographic-Derived Strain-Area Loop of the Right Ventricle is Related to Pulmonary Vascular Resistance in Pulmonary ... Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences; Radboudumc 6: Metabolic Disorders RIHS: Radboud ...
Lifschitz, M. D. ; Burns, T. ; Stein, J. H. / Prostaglandin E (PGE) excretion and renal vascular resistance. In: Kidney ... Lifschitz, M. D., Burns, T., & Stein, J. H. (1976). Prostaglandin E (PGE) excretion and renal vascular resistance. Kidney ... Lifschitz, MD, Burns, T & Stein, JH 1976, Prostaglandin E (PGE) excretion and renal vascular resistance, Kidney international ... title = "Prostaglandin E (PGE) excretion and renal vascular resistance",. author = "Lifschitz, {M. D.} and T. Burns and Stein ...
Online Health Calculator which calculates the Systemic vascular resistance from the given values of cardiac output, Central ... Systemic Vascular Resistance. Online Health Calculator which calculates the Systemic vascular resistance from the given values ... Calculator of Systemic Vascular Resistance. Mean Artery Pressure(MAP):. mmHg. cmH2O. kpa. atm. psi. ...
Sukumar IP, Palmer WH, Yudin H, Baile L. Effect of heart rate on coronary vascular resistance. Indian Heart Journal. 1975 Apr; ...
Association between muscular strength and intrarenal vascular resistance in middle-aged and older individuals」の研究トピックを掘り下げます。これ ... Association between muscular strength and intrarenal vascular resistance in middle-aged and older individuals. In: Experimental ... Association between muscular strength and intrarenal vascular resistance in middle-aged and older individuals. / Kosaki, Keisei ... Association between muscular strength and intrarenal vascular resistance in middle-aged and older individuals. Experimental ...
Two important factors-vascular resistance and blood flow-exist in the development of portal hypertension. ... Thus, changes in portal vascular resistance are determined primarily by blood vessel radius. Because portal vascular resistance ... Increase in vascular resistance. The initial factor in the etiology of portal hypertension is an increase in the vascular ... Liver disease that decreases the portal vascular radius produces a dramatic increase in the portal vascular resistance. In ...
... atrial antiarrhythmic vernakalant and the class IC antiarrhythmic agent flecainide in human isolated subcutaneous resistance ... Vascular Resistance / drug effects * Vasodilation / drug effects * Vasodilator Agents / pharmacology* Substances * Anisoles ... The lack of effects of vernakalant on human resistance artery tone and ventricular muscle contractile function suggests that ... displayed no significant direct effects on human resistance artery tone or ventricular contractility. In contrast, tested at ...
Alteration in systemic vascular resistance and cardiac output during acute cellular rejection and recovery in heart transplant ... Alteration in systemic vascular resistance and cardiac output during acute cellular rejection and recovery in heart transplant ... Alteration in systemic vascular resistance and cardiac output during acute cellular rejection and recovery in heart transplant ... Alteration in systemic vascular resistance and cardiac output during acute cellular rejection and recovery in heart transplant ...
Decreased Systemic Vascular Resistance. A decrease in systemic vascular resistance can lead to a decline in effective ... Traditionally, arterial volume has received the greatest attention because along with vascular resistance, they are the major ... However, resistance to ANP and other natriuretic peptides is common, and several mechanisms have been postulated, including ... Thus, terms such as "intravascular volume" or "effective arterial blood volume" have been championed to describe the vascular ( ...
George J. Vournazos Resume One shop the resistance vasculature a publication of the university of vermont center for vascular ... Firm Practice Areas shop the resistance vasculature a publication of the university of vermont center for vascular research ... Better Business Bureau Our shop the resistance vasculature a publication of the university of vermont center for vascular ... Will County shop the resistance vasculature a publication of the university of vermont center for vascular research 1991 citas ...
... peripheral vascular resistance; WBC = white blood cell. ... possible source of sepsis or septic shock after other vascular ... prompt removal of intravascular access devices that are a possible source of sepsis or septic shock after other vascular access ...
Oral contraceptives, insulin resistance and ischemic vascular disease. Int J Gynaecol Obstet 1990;31(3):263-9. CrossRef PubMed ... Glucocorticoids and insulin resistance: old hormones, new targets. Clin Sci 1999;96:513-23. CrossRef PubMed ... These higher levels of cortisol contribute to glucose intolerance and insulin resistance, which if left untreated can lead to ...
Three patients developed early vascular thromboses that were detected by the absence of a Doppler signal. In patients making an ... All recipients were shown to have high-velocity segments within the hepatic artery, without an increase in flow resistance. ... which were not associated with the development of vascular complications or affect patient management. ... and vascular complications are associated with abnormal values. We analyzed the findings of 51 consecutive patients who ...
Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension. Am J Resp Crit Care ... Resistance of group B streptococcus to selected antibiotics, including erythromycin and clindamycin. J Clin Microbiol. 2004 Mar ... Review: chlorhexidine gluconate is more effective than povidone-iodine for preventing vascular catheter related bloodstream ... Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics and electrical brain activity. Pediatrics ...
Pulmonary vascular resistance , 240 dyn.sec/cm5 or , 3 mm Hg/liter (L)/minute; ...
The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and ... Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular ... including amyloid-β-independent vascular changes, amyloid-β-dependent vascular changes and combined amyloid-β and vascular ... Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimers disease. Brain Pathol. 23, 303- ...
... a possible modality to assessing the reversibility of pulmonary vascular resistance. Journal of Artificial Organs, 18(3), 284. ... a possible modality to assessing the reversibility of pulmonary vascular resistance, Journal of Artificial Organs, vol. 18, no ... a possible modality to assessing the reversibility of pulmonary vascular resistance. Journal of Artificial Organs. 2015 Sep 4; ... a possible modality to assessing the reversibility of pulmonary vascular resistance. In: Journal of Artificial Organs. 2015 ; ...
Dive into the research topics of Cardiovascular Magnetic Resonance catheterization derived pulmonary vascular resistance and ... Cardiovascular Magnetic Resonance catheterization derived pulmonary vascular resistance and medium-term outcomes in congenital ... Cardiovascular Magnetic Resonance catheterization derived pulmonary vascular resistance and medium-term outcomes in congenital ... title = "Cardiovascular Magnetic Resonance catheterization derived pulmonary vascular resistance and medium-term outcomes in ...
... and pulmonary vascular resistance (PVR). We tested the hypothesis that the transit time during contrast echocardiography could ... From: Estimation of cardiac output and pulmonary vascular resistance by contrast echocardiography transit time measurement: a ...
Pulmonary Vascular Resistance Pulmonary vascular resistance (PVR) is similar to systemic vascular resistance (SVR) except it ... Pulmonary Vascular Resistance. /getattachment/580ac2f0-8b65-4bed-b5b7-bebca015ff2a/Pulmonary-Vascular-Resistance.aspx ...
Previous work revealed a strong role for hsa-miR-181b-5p in vascular inflammation in obesity, insulin resistance, sepsis, and ... Ying, W. et al. miR-150 regulates obesity-associated insulin resistance by controlling B cell functions. Sci.Rep. 6, 20176 ( ... Shah, R. et al. Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic ...
Vascular resistance (forearm): significant increase (p , 0.05). Between-group comparisons. 50 mg/day or placebo. 4 weeks. ... isoflavones on plasma lipids and insulin resistance in healthy premenopausal women. Br. J. Nutr. 2003, 89, 467-474. [Google ...
Dexmedetomidine tended to increase pulmonary vascular resistance. Dexmedetomidine alone had no statistically significant effect ... and systemic vascular resistance was noted. No dogs experienced hypotension. ...
  • Online Health Calculator which calculates the Systemic vascular resistance from the given values of cardiac output, Central venous pressure and Mean artery pressure. (
  • To investigate whether peripheral vascular compensatory mechanisms are preserved after orthotopic heart transplantation (OHT), we longitudinally observed systemic vascular resistance (SVR) and cardiac output (CO) during acute cellular rejection. (
  • Pulmonary vascular resistance (PVR) is similar to systemic vascular resistance (SVR) except it refers to the arteries that supply blood to the lungs. (
  • AVP dose-dependently enhanced systemic vascular resistance (SVR) and decreased cardiac output (CO). After prior V1A receptor blockade, SVR was reduced and CO increased (0.1 ng/kg/min + 1 ng/kg/min AVP). (
  • 2 This may reflect a hypertensive state related to increased systemic vascular resistance associated with a retained calf. (
  • The total vascular resistance in the systemic circulation. (
  • Vasoplegic syndrome (VS) is defined as a syndrome of low systemic vascular resistance (SVR) in the presence of normal or high cardiac output 1-4 . (
  • Until then, however, beta blockade is still indicated in NonSTEMI when the patient has hypertension and also if there is tachycardia (tachycardia that is not compensatory for low stroke volume, which may be due to poor LV function, valvular disease, low left ventricular end-diastolic volume, or low systemic vascular resistance). (
  • 2) Nevertheless, it is known that COVID-19 is a respiratory disease with vascular implications that interact with cardiometabolic factors such as oxidative stress, endothelial dysfunction, insulin resistance, atherosclerosis, overweight, increased body fat and alterations in the microbiome, leading to systemic complications and death. (
  • Increased insulin resistance is associated with vascular cognitive impairment in Chinese patients with cerebral small vessel disease. (
  • Vascular dysfunction occurs early in the atherosclerotic process and is associated with obesity and insulin resistance ( 4 ). (
  • The disease presents with metabolic anomalies characterized by chronic hyperglycaemia, resulting from defective secretion or action of insulin (insulin resistance) or both. (
  • Diabetes is characterised by high blood sugar level (hyperglycaemia) due to less/no secretion of insulin or insulin resistance. (
  • PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble. (
  • Furthermore, we describe evidence of arterial and arteriolar blood flow control by vascular smooth muscle cells (VSMCs), astrocyte-mediated, direct neuron-mediated and endothelium-mediated regulation of VSMC tone. (
  • It is not known whether the ACE present in vascular endothelium is inhibited longer than the ACE in circulating blood. (
  • The vascular endothelium is formed by a sheet of endothelial cells tethered together by junctional proteins such as tight and adherens junctions. (
  • Dysfunction of vascular endothelium is an early and critical event in the development of vascular complications. (
  • Restitution of blood volume, as determined by dilution of hematocrit, was attenuated in fasted rats, although the responses of arterial blood pressure, heart rate, cardiac output, and total peripheral resistance were not significantly different. (
  • Echocardiographic-Derived Strain-Area Loop of the Right Ventricle is Related to Pulmonary Vascular Resistance in Pulmonary Arterial Hypertension. (
  • The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (
  • the abdominal fluid accumulation related to bowel inflammatory disease is more likely to be secondary to venous, as opposed to arterial vascular leakage. (
  • o acúmulo de líquido abdominal relacionado à doença inflamatória intestinal é mais provável de ser secundária a venosa, em oposição à fuga vascular arterial. (
  • The end result of the above mechanisms is increased pulmonary arterial pressure and resistance. (
  • At a critical point, a further increase in pulmonary arterial pressure and resistance produces significant RV dilatation, an increase in RV end-diastolic pressure, and RV circulatory failure. (
  • Multiple methods have been developed to evaluate vascular function noninvasively, including several measures of arterial stiffness, such as brachial distensibility, pulse wave velocity (PWV), and augmentation index ( 5 ). (
  • BP depends on cardiac output and peripheral vascular resistance. (
  • It may occur due to an imbalance between cardiac output and peripheral vascular resistance. (
  • Attributed Medicinal Properties for cardio vascular conditions are numerous. (
  • With the same purpose, it is necessary to use mass media on a broader basis as well as disseminate published for population booklets and popular brochures on measures of control and prevention of cardio-vascular diseases, strengthening resistance of people to external negative impact and strengthening of protective factors. (
  • Special attention will be paid to prevention of cardio-vascular diseases, reduction of micronutrient insufficiency, stabilization of infectious diseases incidence rate including TB, malaria, helminthiasis, brucellosis, restriction of dissemination of HIV/AIDS and immunization-sensitive infections. (
  • These are valid questions, since eating properly is just as important to your health as lifting weights and doing enough cardio-vascular training. (
  • IMSEAR at SEARO: Effect of heart rate on coronary vascular resistance. (
  • Sukumar IP, Palmer WH, Yudin H, Baile L. Effect of heart rate on coronary vascular resistance. (
  • Phosphine is a respiratory tract irritant that attacks primarily the cardiovascular and respiratory systems causing peripheral vascular collapse, cardiac arrest and failure, and pulmonary edema. (
  • Systemically, magnesium lowers blood pressure and alters peripheral vascular resistance. (
  • Myocardial depression with increased peripheral vascular resistance is also common. (
  • Peripheral vascular resistance have included here is intended to our patient. (
  • OPG has been associated with vascular inflammation and remodelling and may be important in cardiovascular disease where OPG levels may be elevated. (
  • Diabetes is serious due to its complications, namely: cardiovascular ailments, cerebral vascular accidents, renal insufficiency, blindness, sexual impotence and gangrene of the feet leading to amputation. (
  • it regulates endothelial cell function by induction of nitric oxide and vasodilatation and decreases vascular tone and blood pressure [ 2 ]. (
  • In conclusion, a wide range of abnormalities occurs in the vessels of liver transplant recipients, which were not associated with the development of vascular complications or affect patient management. (
  • In addition, we examine vascular dysfunction in animal models, including amyloid-β-independent vascular changes, amyloid-β-dependent vascular changes and combined amyloid-β and vascular models. (
  • Last, we emphasize Alzheimer disease vascular dysfunction, including cerebrovascular reactivity, cerebral blood flow reductions and neurovascular uncoupling. (
  • Figure 4: Neurovascular dysfunction in Alzheimer disease: two-hit vascular hypothesis. (
  • Exposure of resistance arteries to OPG induced endothelial (decreased relaxation to acetylcholine) and VSMC (decreased relaxation to sodium nitroprusside - SNP) dysfunction, as well as, increased contraction to phenylephrine. (
  • In conclusion, vascular dysfunction elicited by OPG is mediated by syndecan-1 and ROS. (
  • Recent clinical and animal studies have suggested that ventricular- vascular coupling normally operates at either optimal ventricular efficiency (EFF = stroke work/myocardial oxygen consumption) or stroke work (SW) and that efficiency in particular is compromised by cardiac dysfunction. (
  • It also decreases renal vascular resistance increasing the renal blood flow, thus improving the GFR. (
  • Doppler ultrasound (DUS) is able to measure parameters of blood flow within vessels of transplanted organs, and vascular complications are associated with abnormal values. (
  • On the contrary, the low occurrence of ischemia in some other studies, may be possibly linked to the fact that the patients died following a cardiogenic shock before the development of the clinical diagnosis of vascular complications. (
  • Here macro vascular diseases like atheroma and thrombotic complications while microangiopathy diseases are associated with retina, kidney and peripheral nerves. (
  • BACKGROUND/AIMS Vascular insufficiency due to abnormal autoregulation has been proposed as a major factor in the development of glaucoma. (
  • While elevated intraocular pressure (IOP) is a clear risk factor, vascular insufficiency and abnormal autoregulation of the optic nerve circulation have been hypothesised to play a significant role in the development and progression of glaucoma. (
  • PVRI: pulmonary vascular resistance index. (
  • Pulmonary vascular resistance (PVRI) was below 3.5 in all cases (range 1.0-3.5 units). (
  • Rat endothelial cells (EC) and vascular smooth muscle cells (VSMC) were studied. (
  • 9-15 An increase in mean and end diastolic velocity and a decrease in resistance index have been noted in the central retinal and short posterior ciliary arteries of glaucoma patients after trabeculectomy. (
  • When vessels dilate, the flow of blood is increased due to a decrease in vascular resistance. (
  • Carvedilol has anti-adrenergic vasodilatory effects that decrease intrahepatic vascular resistance, and it offers an advantage over propranolol and nadolol in reducing portal pressures. (
  • Functional, hemodynamic and imaging (cardiac magnetic resonance and echocardiography) assessment at baseline and 36 weeks included changes in right ventricular mass and pulmonary vascular resistance (RV mass and PVR) as co-primary end-points, and stroke volume/pulmonary pulse pressure (SV/PP), tricuspid annular plane systolic excursion (TAPSE), six-minute walk distance (6MWD) and N-terminal pro-brain natriuretic peptide (NT-proBNP), all secondary end-points. (
  • For example, in response to infusion of pressor agents, renal autoregulation is almost unimpaired, while regulation in the mesenteric vascular bed is less good, and differs with the different agents. (
  • Vascular reactivity of resistance arteries from WKY rats was studied by wire myography in the presence or absence of OPG (50 ng/mL) and/or synstatin (SSNT - 10 -6 M - syndecan-1 inhibitor). (
  • Reduce the peripheral resistance of patients with hypertension, renal vascular resistance obviously decreased, no antihypertensive effect on normal people. (
  • Iadecola, C. The pathobiology of vascular dementia. (
  • However, fasting did not significantly alter the response of flow or vascular resistance to these organs. (
  • These results demonstrate that 24 h of fasting does not affect the responses of blood flow and vascular resistance to hemorrhage in most organs, even though restitution of blood volume is attenuated. (
  • The increasing prevalence of antimicrobial resistance (17,18). (
  • Fasting only affected resting blood flow in the bronchial artery and fat and had no effect on resting vascular resistance in any organ studied. (
  • This study explored the intrinsic vasorelaxant and inotropic effects of the mixed potassium and sodium channel blocker atrial antiarrhythmic vernakalant and the class IC antiarrhythmic agent flecainide in human isolated subcutaneous resistance artery and in ventricular trabecular muscle preparations. (
  • At test concentrations encompassing free plasma concentrations associated with clinical efficacy for conversion of atrial fibrillation, vernakalant (1-10 μM) displayed no significant direct effects on human resistance artery tone or ventricular contractility. (
  • In contrast, tested at equimolar concentrations, flecainide significantly reduced peak isometric contractile force (10 μM) and maximal rates of force development and decline (3 and 10 μM) in the human ventricular muscle preparation while displaying no significant effect on human resistance artery tone. (
  • The lack of effects of vernakalant on human resistance artery tone and ventricular muscle contractile function suggests that direct vasorelaxant and inotropic effects do not underlie the rare hypotensive events observed clinically with vernakalant, raising the possibility that secondary (eg, reflex) effects may mediate these events. (
  • The demonstration of negative inotropic effects with flecainide in the human ventricular muscle preparations in the absence of an effect on resistance artery tone suggests that the hemodynamic effects of flecainide observed clinically result primarily from direct negative inotropic effects. (
  • All recipients were shown to have high-velocity segments within the hepatic artery, without an increase in flow resistance. (
  • 21 Acute incremental elevation of IOP in healthy human subjects resulted in a progressive drop in central retinal artery blood flow velocities implying a close link among mechanical and haemodynamic factors in this particular vascular bed. (
  • Three patients developed early vascular thromboses that were detected by the absence of a Doppler signal. (
  • Figure 1: A schematic representation of the neurovascular unit showing cellular elements regulating cerebral blood flow along the vascular tree. (
  • Changes in vascular permeability are commonly present in certain clinical diseases and when occurring in the lung or brain lead to serious consequences related to impaired gas exchange and cerebral function, respectively. (
  • The actual increase in the incidence of VRE in U.S. hospitals might be greater than reported because the fully automated methods used in many clinical laboratories cannot consistently detect vancomycin resistance, especially moderate vancomycin resistance (as manifested in the VanB phenotype) (9-11). (
  • 17 These findings and the possible association of normal tension glaucoma with vasospastic angina, migraine headache, and Raynaud's disease 18-20 add further support to a vascular contribution to glaucomatous optic nerve damage. (
  • Pulmonary hypertension is associated with changes in vascular tone as well as vascular structure, with the relative contribution of each dependent upon the aetiology of the increased pulmonary vascular resistance. (
  • For a given inotropic state [indexed by the slope of the end-systolic pressure-volume relationship (E(es))], myocardial oxygen consumption and SW were measured over a broad range of afterload resistances. (
  • build shop the resistance vasculature and exponential Neyman-Pearson term hypothesis? (
  • Although the number of opiate injecting drug users may have increased in the 1990s ( 8 ), the rapid and substantial increase in admissions for SSTIs and vascular disease suggests that this has not resulted from an increase in the injecting population alone. (
  • Other evidence suggests that oil drawn from these fatty fish may ease muscle soreness following resistance training. (
  • Our aim was to evaluate the cardiac and vascular characteristics of patients with SRSTH due to TRB mutations.Materials and methods: We analysed cl. (
  • If we can predict how effectively each disinfectant method would deactivate or degrade a specific gene, then we can better evaluate effective treatment strategies for degrading any antibiotic resistance gene that presents a concern,' Dodd said. (
  • It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT . (
  • Our profiling data provided a rich source for further study of the molecular mechanisms of acquired drug resistance inneuroblastoma ( NB). (
  • Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations. (
  • Background: Selection of patients with congenital heart disease for surgical septation in biventricular repair or surgical palliation in functionally single ventricles requires low pulmonary vascular resistance (PVR). (
  • The primary endpoint is a change in pulmonary vascular resistance at 16 weeks from baseline. (
  • Outcomes studies of antimicrobial drug resistance are and study patients infected with resistant bacteria (the notoriously hard to perform because of confounding vari- exposure of interest for cases), who are compared either to ables related to underlying coexisting conditions (1). (
  • the corresponding susceptible bacteria, the impact of In the analysis comparing patients with SSI caused by acquiring a resistance determinant is measured. (
  • Vancomycin resistance in enterococci has coincided with the increasing incidence of high-level enterococcal resistance to penicillin and aminoglycosides, thus presenting a challenge for physicians who treat patients who have infections caused by these microorganisms (1,4). (
  • Il s'agit d'une étude transversale, monocentrique et descriptive, durant 12 mois, incluant les patients âgés d'au moins 18 ans admis en réanimation polyvalente pour un sepsis ou choc septique. (
  • In 169 middle-aged and older individuals without renal disease, handgrip strength (HGS) and the renal resistive index (RRI) were measured as the parameters of muscular strength and intrarenal vascular resistance, respectively. (
  • The factors controlling vascular permeability in health and disease are poorly understood. (
  • For obstructive vascular disease, KETANSERIN TARTRATE can improve lower limb blood supply. (
  • The injecting of illicit drugs is associated with skin and soft tissue infections (SSTIs) and vascular disease ( 1 - 3 ). (
  • We aimed to identify emerging trends in hospital admission for SSTIs and vascular disease arising from drug use and, specifically, where these may have occurred after injection of the femoral vein. (
  • Diabetes leads to blood vessels disorder which can be either large-macro vascular disease or small disease-microangiopathy. (
  • Coronary vascular reserve is impaired during acute cellular rejection of the orthotopically transplanted heart, but changes in the peripheral vasculature during rejection have not been well described. (
  • 1-4 It is possible that mechanical and vascular factors have a synergistic interaction. (
  • The pathophysiology of these phenomena is explained by excess placental soluble fms like tyrosin kinase-1 (sFlt-1) that binds circulating vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) and prevents their interaction with endothelial cell-surface receptors. (
  • These data show that both SW and efficiency are nearly maximal under many conditions of ventricular-vascular interaction. (
  • US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. (
  • As a common characteristic of cancer, hypoxia is associated with poor prognosis due to enhanced tumor malignancy and therapeutic resistance. (
  • the functioning of the heart and the resistance of the blood vessels. (
  • vascular permeability was present at all measurements for both vessels and its magnitude directly proportional to the intravascular pressure. (
  • The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. (
  • The V1A receptors are found on various cells including vascular smooth muscle cells, the V2 receptor is mainly found in the kidneys [ 3 ], and the V1B receptors are predominantly located in the adenohypophysis [ 4 ]. (
  • PVR is the resistance to flow which must be overcome to push blood through the lungs. (
  • CMR/XMR catheterization is a validated technique for accurate assessment of pulmonary vascular resistance. (
  • Osteoprotegerin (OPG), an inhibitor of vascular calcification, has pleiotropic vascular effects independently of its actions on calcification. (
  • Society for Vascular Medicine. (
  • Angiography and Interventions and the Society for Vascular Medicine. (
  • To determine how these methods affect both bacteria and antibiotic resistance genes, Dodd and his team used a model system: a harmless soil bacterium called Bacillus subtilis. (
  • The team determined that these three methods are largely successful in preventing the spread of antibiotic resistance by both deactivating the bacteria and damaging the resistance gene. (
  • In fact, we found that DNA from bacteria treated with chlorine dioxide and monochloramine retains the ability to transfer antibiotic resistance traits to non-resistant bacteria long after the original bacteria are killed. (
  • THURSDAY, Aug. 27, 2020 (HealthDay News) -- Admissions for stroke and transient ischemic attack (TIA) have decreased during the COVID-19 pandemic, according to a study published online Aug. 26 in Stroke and Vascular Neurology . (