Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
A thiol-containing amino acid formed by a demethylation of METHIONINE.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
The nonstriated involuntary muscle tissue of blood vessels.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 µmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
The main trunk of the systemic arteries.
A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
The inferior part of the lower extremity between the KNEE and the ANKLE.
An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
The main artery of the thigh, a continuation of the external iliac artery.
Operative procedures for the treatment of vascular disorders.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.
The vessels carrying blood away from the heart.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
Formation and development of a thrombus or blood clot in the blood vessel.
Elements of limited time intervals, contributing to particular results or situations.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Death and putrefaction of tissue usually due to a loss of blood supply.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Radiography of blood vessels after injection of a contrast medium.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.
Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Enzymes catalyzing the dehydrogenation of secondary amines, introducing a C=N double bond as the primary reaction. In some cases this is later hydrolyzed.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
Pathological processes involving any part of the AORTA.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Inflammation of the inner endothelial lining (TUNICA INTIMA) of an artery.
The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.
The region of the lower limb between the FOOT and the LEG.
An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Pathologic deposition of calcium salts in tissues.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This enzyme was formerly classified as EC
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The flow of BLOOD through or around an organ or region of the body.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
Prosthetic replacements for arms, legs, and parts thereof.
Nutrient blood vessels which supply the walls of large arteries or veins.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.
Conditions with excess LIPIDS in the blood.
The blood vessels which supply and drain the RETINA.
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
Any one of five terminal digits of the vertebrate FOOT.
Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).
Hypertrophy and dilation of the RIGHT VENTRICLE of the heart that is caused by PULMONARY HYPERTENSION. This condition is often associated with pulmonary parenchymal or vascular diseases, such as CHRONIC OBSTRUCTIVE PULMONARY DISEASE and PULMONARY EMBOLISM.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Autosomal recessive inborn error of methionine metabolism usually caused by a deficiency of CYSTATHIONINE BETA-SYNTHASE and associated with elevations of homocysteine in plasma and urine. Clinical features include a tall slender habitus, SCOLIOSIS, arachnodactyly, MUSCLE WEAKNESS, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence of MENTAL RETARDATION, and a tendency to develop fibrosis of arteries, frequently complicated by CEREBROVASCULAR ACCIDENTS and MYOCARDIAL INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, p979)
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Inhaling and exhaling the smoke of burning TOBACCO.
A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.
Drugs used to cause dilation of the blood vessels.
The part of the foot between the tarsa and the TOES.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
The part of a limb or tail following amputation that is proximal to the amputated section.
Pathological conditions involving the HEART including its structural and functional abnormalities.
An FAD-dependent oxidoreductase found primarily in BACTERIA. It is specific for the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This enzyme was formerly listed as EC and
Blockage of the RETINAL VEIN. Those at high risk for this condition include patients with HYPERTENSION; DIABETES MELLITUS; ATHEROSCLEROSIS; and other CARDIOVASCULAR DISEASES.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
An idiopathic, segmental, nonatheromatous disease of the musculature of arterial walls, leading to STENOSIS of small and medium-sized arteries. There is true proliferation of SMOOTH MUSCLE CELLS and fibrous tissue. Fibromuscular dysplasia lesions are smooth stenosis and occur most often in the renal and carotid arteries. They may also occur in other peripheral arteries of the extremity.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The vessels carrying blood away from the capillary beds.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A sulfur-containing essential L-amino acid that is important in many body functions.
Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Inflammation of the wall of the AORTA.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.
The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Central retinal artery and its branches. It arises from the ophthalmic artery, pierces the optic nerve and runs through its center, enters the eye through the porus opticus and branches to supply the retina.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.
Inability to achieve and maintain an erection (ERECTILE DYSFUNCTION) due to defects in the arterial blood flow to the PENIS, defect in venous occlusive function allowing blood drainage (leakage) from the erectile tissue (corpus cavernosum penis), or both.
The condition of an anatomical structure's being constricted beyond normal dimensions.
A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Abnormally high BLOOD GLUCOSE level.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
A natural product that has been considered as a growth factor for some insects.
Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The veins and arteries of the HEART.
A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.
Subspecialty of radiology that combines organ system radiography, catheter techniques and sectional imaging.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Methods and procedures for the diagnosis of diseases or dysfunction of the cardiovascular system or its organs or demonstration of their physiological processes.
Techniques for measuring blood pressure.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.
An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.

Systemic infection with Alaria americana (Trematoda). (1/2352)

Alaria americana is a trematode, the adult of which is found in mammalian carnivores. The first case of disseminated human infection by the mesocercarial stage of this worm occurred in a 24-year-old man. The infection possibly was acquired by the eating of inadequately cooked frogs, which are intermediate hosts of the worm. The diagnosis was made during life by lung biopsy and confirmed at autopsy. The mesocercariae were present in the stomach wall, lymph nodes, liver, myocardium, pancreas and surrounding adipose tissue, spleen, kidney, lungs, brain and spinal cord. There was no host reaction to the parasites. Granulomas were present in the stomach wall, lymph nodes and liver, but the worms were not identified in them. Hypersensitivity vasculitis and a bleeding diathesis due to disseminated intravascular coagulation and a circulating anticoagulant caused his death 8 days after the onset of his illness.  (+info)

Study of an epidemic of venoocclusive disease in India. (2/2352)

Twenty-five cases of rapidly developing ascites occurring in an epidemic form were observed in a tribal district in Central India during August 1972-May 1973. Eleven of the patients died. Six patients were brought to hospital and studied for periods of two to 17 months. Necropsy was performed on one patient who died. The clinical features suggested an outflow tract obstruction such as a Budd-Chiari-like syndrome or venoocclusive disease. Radiographic and haemodynamic studies demonstrated a combination of post and perisinusoidal blocks. Liver dysfunction was indicated by the presence of a marked bromsulphthalein retention and mild to moderate hypoalbuminaemia. Histological examination of the liver biopsies showed changes that ranged from centrizonal haemorrhagic necrosis to an extensive centrilobular fibrosis associated with central vein occlusion. The disease was apparently caused by a food toxin, and the possible nature of this is discussed.  (+info)

Prevalence of angiographic atherosclerotic renal artery disease and its relationship to the anatomical extent of peripheral vascular atherosclerosis. (3/2352)

BACKGROUND: Recognition of the possible presence of atherosclerotic renal artery disease (ARAD) is important because of its progressive nature, and because of the potential for precipitating an acute deterioration in renal function by administration of angiotensin-converting enzyme inhibitors. The aim of this study was to identify the prevalence of ARAD in patients undergoing peripheral angiography and its relationship to the extent of their peripheral vascular disease (PVD). METHODS: The reports of the 218 patients who underwent peripheral angiography to investigate PVD in one centre in a calendar year, and in whom it was possible to image the renal arteries, were analysed retrospectively. The presence of atherosclerotic disease in the renal, aortic, iliac, femoral and distal areas was recorded for each patient. RESULTS: The prevalence of ARAD was 79/218 (36.2%). The greater the number of atherosclerotic areas of the arterial tree, the higher the prevalence of ARAD. Patients with aortic disease and bilateral iliac, femoral and distal vessel disease had the highest incidence of ARAD 19/38 (50%). The incidence of ARAD in those with femoral artery atherosclerosis was significantly higher than in those without femoral artery atherosclerosis (42.1% compared with 9.7%, P=0.001 chi2). There was no significant difference in those groups with or without iliac and distal disease. None of the 11 patients with normal femoral and iliac arteries had ARAD. CONCLUSIONS: Renal artery atherosclerosis is a common occurrence in patients with PVD. If extensive PVD is recognized during aortography, a high flush should be considered to examine the renal arteries, if they are not included in the main study.  (+info)

Relief of obstructive pelvic venous symptoms with endoluminal stenting. (4/2352)

PURPOSE: To select patients for percutaneous transluminal stenting of chronic postthrombotic pelvic venous obstructions (CPPVO), we evaluated the clinical symptoms in a cohort of candidates and in a series of successfully treated patients. METHODS: The symptoms of 42 patients (39 women) with CPPVO (38 left iliac; average history, 18 years) were recorded, and the venous anatomy was studied by means of duplex scanning, subtraction venography, and computed tomography or magnetic resonance imaging. Successfully stented patients were controlled by means of duplex scanning and assessment of symptoms. RESULTS: The typical symptoms of CPPVO were reported spontaneously by 24% of patients and uncovered by means of a targeted interview in an additional 47%. Of 42 patients, 15 had venous claudication, four had neurogenic claudication (caused by dilated veins in the spinal canal that arise from the collateral circulation), and 11 had both symptoms. Twelve patients had no specific symptoms. Placement of a stent was found to be technically feasible in 25 patients (60%), was attempted in 14 patients, and was primarily successful in 12 patients. One stent occluded within the first week. All other stents were fully patent after a mean of 15 months (range, 1 to 43 months). Satisfaction was high in the patients who had the typical symptoms, but low in those who lacked them. CONCLUSION: Venous claudication and neurogenic claudication caused by venous collaterals in the spinal canal are typical clinical features of CPPVO. We recommend searching for these symptoms, because recanalization by means of stenting is often feasible and rewarding.  (+info)

Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. (5/2352)

Receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules and engages diverse ligands relevant to distinct pathological processes. One class of RAGE ligands includes glycoxidation products, termed advanced glycation end products, which occur in diabetes, at sites of oxidant stress in tissues, and in renal failure and amyloidoses. RAGE also functions as a signal transduction receptor for amyloid beta peptide, known to accumulate in Alzheimer disease in both affected brain parenchyma and cerebral vasculature. Interaction of RAGE with these ligands enhances receptor expression and initiates a positive feedback loop whereby receptor occupancy triggers increased RAGE expression, thereby perpetuating another wave of cellular activation. Sustained expression of RAGE by critical target cells, including endothelium, smooth muscle cells, mononuclear phagocytes, and neurons, in proximity to these ligands, sets the stage for chronic cellular activation and tissue damage. In a model of accelerated atherosclerosis associated with diabetes in genetically manipulated mice, blockade of cell surface RAGE by infusion of a soluble, truncated form of the receptor completely suppressed enhanced formation of vascular lesions. Amelioration of atherosclerosis in these diabetic/atherosclerotic animals by soluble RAGE occurred in the absence of changes in plasma lipids or glycemia, emphasizing the contribution of a lipid- and glycemia-independent mechanism(s) to atherogenesis, which we postulate to be interaction of RAGE with its ligands. Future studies using mice in which RAGE expression has been genetically manipulated and with selective low molecular weight RAGE inhibitors will be required to definitively assign a critical role for RAGE activation in diabetic vasculopathy. However, sustained receptor expression in a microenvironment with a plethora of ligand makes possible prolonged receptor stimulation, suggesting that interaction of cellular RAGE with its ligands could be a factor contributing to a range of important chronic disorders.  (+info)

Chronic retinal vein occlusion in glaucoma. (6/2352)

Asymptomatic chronic retinal vein occlusion that occurs in chronic simple glaucoma is described. The condition is characterized by marked elevation of retinal vein pressure with collateral vessels and vein loops at the optic disc in cases of central vein occlusion, or retinal veno-venous anastomoses along a horizontal line temporal and nasal to the disc in hemisphere vein occlusion. No patient had visible arterial changes, capillary closure, fluorescein leakage, or haemorrhages. The vein occlusion was not limited to "end stage" glaucoma. The role of increased intraocular pressure and glaucomatous enlargement of the optic cup with retinal vein distortion in the pathogenesis of the condition was stressed. Follow-up of these patients revealed persistence of the retinal vein occlusion shown by elevated retinal vein pressures. This would reduce effective perfusion of the inner retina and optic disc and may affect the long-term visual prognosis.  (+info)

Perifoveal vascular leakage and macular oedema after intracapsular cataract extraction. (7/2352)

Perifoveal capillary leakage of fluorescein was demonstrated in 60 per cent of 50 eyes when angiography was performed two weeks after cataract extraction. Repeat angiography six weeks postoperatively in 17 eyes demonstrated persistence of already established leakage in 11 of 12 eyes and no new leakage in five eyes previously negative. Cystoid macular oedema with visual acuity of less than 20/40 six weeks postoperatively occurred in five eyes (10 per cent). Eyes of patients with vascular disease and those patients of 60 years or older were found to have altered vascular permeability significantly more frequently. Inflammation was no more severe or prevalent in those patients who demonstrated leakage and no inflammation was clinically apparent in 10 of 11 eyes demonstrating dye leakage six weeks postoperatively. We conclude that the constitutional factors of age and vascular disease are of prime importance in causing altered vascular permeability in the early postoperative period after cataract extraction; factors causing sustained leakage with reduction of visual acuity were not demonstrated.  (+info)

A prospective study of xenon arc photocoagulation for central retinal vein occlusion. (8/2352)

Twenty patients with central retinal vein occlusion were randomly divided into two groups in a prospective study to evaluate the effects of xenon are photocoagulation in central retinal vein occlusion. The patients in one group were treated with 360 degrees scatter xenon photocoagulation and the others received no treatment. The average follow-up was 18 months. There were no cases of rubeosis or neovascular glaucoma in the treated group. Two patients in the untreated group developed rubeosis with subsequent neovascular glaucoma. There was no significant difference in the visual prognosis or in fundus neovascularization between the groups.  (+info)

Throughout middle and old age, usual blood pressure is strongly and directly related to vascular (and overall) mortality, without any evidence of a threshold down to at least 115/75 mm Hg.
Researchers at Medical College of Georgia have found that circadian clocks that set the rhythmic motion of our bodies for wakeful days and sleepy nights can also set us up for
When it comes to diagnosing vascular disease and treating vascular disease, Hoag Heart & Vascular Institute is a nationally recognized leader.
If there is a proven diagnosis, or even if we just find a little thickening of the arteries in your neck then you need all of the treatments that work for vascular disease. They are the LIFESAVERS and lifestyle changes that you can review in more detail on the information sheet. But thats not all. You also need to be investigated for vascular disease elsewhere, particularly in the heart. Why the heart? Because no matter where else vascular disease is found in your body, your greatest risk of dying from this disease is heart attack or complications of heart attack. For this reason, we look for signs of your heart arteries being involved. This is usually done by having you undergo a stress test either exercising on a treadmill or bike, or if you cant exercise to a high enough level there are ways to use medications to simulate exercise thereby allowing us to find out if there are any blockages. ...
A number of diseases that can affect arteries and veins throughout the body but the most common vascular disease is atherosclerosis, or hardening of the arteries. This condition affects virtually every artery within the body. Peripheral Vascular Disease includes all the arteries and veins in the body except those within the heart and within the brain.
The vascular system is the network of blood vessels that circulate blood to and from the heart and lungs. Vascular diseases are very common, especially a
The vascular disease causes may be different depending on the specific condition. Some of these include smoking, high fat diet, diabetes, lack of physical exercise.
The vascular system is the bodys network of blood vessels. It includes the arteries, veins and capillaries that carry blood to and from the heart. Problems of the vascular system are common and can be serious. Arteries can become thick and stiff, a...
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles.
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It is important for individuals completing a long-distance hike to be aware of the potential deleterious changes associated with large volumes of exercise and consuming a high-calorie, low-quality diet, they conclude in the paper.
It is important for individuals completing a long-distance hike to be aware of the potential deleterious changes associated with large volumes of exercise and consuming a high-calorie, low-quality diet, they conclude in the paper.
Nonetheless, due to limited space we do ask that you invite no collagen vascular disease and pregnancy than 2 collaegn. With my 2nd youngster, I keep in mind getting that crampy feeling right after and it lasted for awhile. Now that a variety of hCG or human Chorionic Gonadotropin hormone is secreted within the physique extra meals aversions, sensitivity to odor, fatigue and constipation may be expected. As I discussed, these guys do not have these issues. Collahen involuntary leaking could occur when coughing, sneezing and collagen vascular disease and pregnancy laughing. As mentioned earlier, its not unusual for a woman to spot during her first 12 weeks of being pregnant. When crucial, I embrace further postpartum visits to insure that diseasd gets off to a terrific begin. Oxytocin itself may cause uterine contractions and thus Collagen vascular disease and pregnancy can cross-react with oxytocin receptors and trigger contractions. A prenatal multivitamin doesnt replace a healthy diet. Cite ...
Question - I have a past history of collagen vascular disease and leukopenia. Is swollen bulging eye and pain behind the ear a symptom of connective tissue disease and autoimmune thyroid ?. Ask a Doctor about Thyroid, Ask a Hematologist has published new research report on Global Peripheral Vascular Disease (PVD) Drug Industry 2012-2022 Market Research Report to its database.. The Global Peripheral Vascular Disease (PVD) Drug Market report has key insights on the global Peripheral Vascular Disease (PVD) Drug Market for the clients who wish to broaden their spectrum in the market and expand their reach. Individuals interested in the report for purely academic purposes also have a substantial amount of data presented to suit their requirements.. The Global Peripheral Vascular Disease (PVD) Drug Market is being actively pursued by a substantial amount of key players across the globe. The market is caught major traction, especially in China which is the reason for the key insights presented in this report for China, along with the globe.. Major Global Markets Thrive with China Holding the Largest Piece of the Pie. The Chinese market for Peripheral Vascular Disease (PVD) Drug has picked up major pace owing to the ...
Psychiatry healthcare professionals gain a thorough knowledge base of psychiatric disorder information to offer the best patient care. Get our FREE app now.
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Nolan on peripheral vascular disease nursing diagnosis: We prefer to use the term pad now but when people use the older term, pvd, they mean the same thing. for topic: Peripheral Vascular Disease Nursing Diagnosis
This thesis presents clinical and experimental studies relating to the effect of cigarette smoking on lipolysis in subjects with various types of vascular disease. The introduction reviews the evidence of the harmful effects of cigarette smoking and for its possible contribution to vascular disease through its action on lipid metabolism via the sympathetic adreno-medullary systems. The aims of the study are then outlined with respect to the effect of smoking varying numbers of cigarettes on levels of free fatty acids (FFA), ketone bodies (aceto-acetate and D hydroxybutyrate), glucose, insulin, cholesterol and triglyceride in subjects with either stable coronary heart disease (CFD) as manifest by angina or with peripheral vascular disease (PVD). The standard situation studied was serial venous sampling under controlled conditions before and after the smoking of two normal nicotine content cigarettes. Initial investigations indicated that a satisfactory steady state was achieved prior to smoking. ...
Upper extremity vascular disease is not common, when compared to lower extremity vascular disease, but has very different kind of diagnostic challenge for physicians.. The most well-known reasons for Upper extremity vascular disease are:. ...
AIMS: To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men. METHODS AND RESULTS: The relevance of inflammatory biomarkers and lipids for vascular and non-vascular mortality was assessed in a prospective study of 5360 men (mean age 77 years) followed for 7 years. Vascular mortality was positively associated with log C-reactive protein (lnCRP), fibrinogen and total/HDL-C (high-density lipoprotein cholesterol), and inversely associated with albumin [age adjusted hazard ratio (HR) per 2-SD higher usual level (approximately the difference between the top and the bottom thirds of the distribution): 2.09 for lnCRP; 1.70 for fibrinogen; 0.50 for albumin and 1.45 for total/HDL-C]. The associations with the inflammatory markers were attenuated after adjustment for established risk factors, including lipids [adjusted HRs: 1.86 (lnCRP); 1.44 (fibrinogen); 0.51 (albumin)], and further attenuated (and, for fibrinogen, no longer predictive) after
What is Vascular Health?. Vascular health is about strengthening your heart and lungs so they perform at their optimal levels. After the age of 55 we are naturally at a higher risk for heart attacks, strokes, high cholesterol, high blood pressure, and peripheral artery disease (P.A.D.). When we live a sedentary life, these problems become even more of a risk. Obesity plays a huge role in causing many of these life-threatening diseases, but there is something you can do about it. Exercising for 30 minutes every day can help stave off these conditions.. Which Exercises Improve Vascular Health?. Cardio exercises, such as running, playing sports or any exercise that gets your heart rate up are considered great for the vascular and respiratory systems. When you put this kind of healthy, controlled stress on your heart and lungs, like any other muscle, they will become stronger. When these organs are strong, they are more able to fight off potential diseases. Typically an exercise that gets your heart ...
Morton Plant Hospital diagnoses, screens and treats for peripheral vascular disease (PVD) and peripheral arterial disease (PAD). Both diseases stem from build up in veins and arteries increasing the risk for heart attack or stroke.
Official journal of the International Society of Vascular Health (ISVH)Indexed:EmBase, Scopus and the Elsevier Bibliographic databasesAmerican Chemical Societys Chemical Abstracts Service (CAS)MedLinePubMedISSN 1176-6344 (Print)ISSN 1178-2048 (Online)An international, peer-reviewed journal of therapeutics and risk management, focusing on concise rapid reporting of clinical studies on the processes involved in the maintenance of vascular health; the monitoring, prevention, and treatment of vascular disease and its sequelae; and the involvement of metabolic disorders, particularly diabetes. In addition, the journal will also seek to define drug usage in terms of ultimate uptake and acceptance by the patient and healthcare professional.Key BenefitsConcise rapid reportingClinical therapeutics and pharmacology focusCardiovascular and metabolic disordersAims and scopeSubject areas include:Endothelial function, inflammation, biochemical and cellular processes, markers, coagulation disorders, and
A systematic review and meta-regression analysis found that statin and nonstatin therapies that act primarily through upregulation of low-density lipoprotein (LDL) receptor expression were associated with similar reductions in LDL cholesterol and relative risks of major vascular events.
If your patient is receiving drug therapy, monitor the effects of the prescribed drugs. Assess the neurovascular status of his legs and report any deterioration in circulation.. Place lambs wool between the patients toes to prevent pressure necrosis. If he has ulcers, provide wound care as needed. Assess the ulcer for signs and symptoms of infection. Cover the ulcer with a dry sterile dressing, topical antibiotic, or other wound care product, as ordered.. If your patient has had surgery for peripheral vascular disease, check his leg for color, temperature, sensation, movement, and pulses during the immediate postoperative period. Report any loss of pulse immediately. Observe the incision site for redness, swelling, and drainage.. Turn and reposition your patient every 2 hours. Tell him to not cross his legs and to avoid severe hip or knee flexion. To aid circulation, add a foot-board to the bed, use a sheepskin under his legs, or place him on an air, pressure, or other special mattress.. If ...
Peripheral vascular disease (PVD) is when blood vessels not located near the heart or brain narrow, inhibiting blood flow and causing pain.
Peripheral Vascular Disease (PVD) is a blockage or narrowing of the blood vessels outside of the heart and brain that gets worse over time.
Trusted information on peripheral vascular disease (also known as peripheral artery disease) including what it is, causes, diagnosis, symptoms, and treatments
Finden Sie alle Bücher von Gautam V. Shrikhande - Diabetes and Peripheral Vascular Disease. Bei der Büchersuchmaschine können Sie antiquarische und Neubücher VERGLEICHEN UND SOFORT zum Bestpreis bestellen. 162703157X
Finden Sie alle Bücher von Gautam V. Shrikhande - Diabetes and Peripheral Vascular Disease. Bei der Büchersuchmaschine können Sie antiquarische und Neubücher VERGLEICHEN UND SOFORT zum Bestpreis bestellen. 9781627031578
The diagnosis and management of peripheral vascular disease in primary care, including methods to manage cardiovascular risk for these patients and optimal therapies to reduce side-effects.
Peripheral vascular disease information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Millions of people in the United States have a circulatory problem of the legs called peripheral vascular disease. It can be painful and may even require surgery in serious cases. This disease can lead to severe skeletal ...
The latest report from Fore Pharma, Peripheral Vascular Disease Pipeline Highlights - 2017, provides most up-to-date information on key pipeline products in the ...
Author:Parul Vadgama, Mehul Bhavsar, Kusum V Shah, Rajesh Solanki, Ramakant Dixit, Jignesh Vaishnani. Keywords:Collagen vascular disease, pulmonary symptoms, sceroderma, rheumatoid arthritis. Type:Original Article. Full PDF Abstract ...
Author:Parul Vadgama, Mehul Bhavsar, Kusum V Shah, Rajesh Solanki, Ramakant Dixit, Jignesh Vaishnani. Keywords:Collagen vascular disease, pulmonary symptoms, sceroderma, rheumatoid arthritis. Type:Original Article. Full PDF Abstract ...
Pietro Nardelli, PhDIstructor in RadiologyDepartment of RadiologyBrigham and Womens HospitalHarvard Medical School Abstract
Amidst the continuing COVID-19 pandemic, concerns have mounted in the vascular community about the disruption to clinical routine.
The National Vascular Disease Prevention Alliance (NVDPA) is a group of four leading health organisations who are working together to reduce the burden of cardiovascular disease in Australia.
The worlds leading voices in the fight against Pulmonary Hypertension have compiled a special publication detailing the breakthrough research into the causes of this debilitating vascular disease.
Types of heart and vascular diseases and conditions affecting the heart, valves, arteries, veins, and the hearts electrical system.
Citation Machine™ helps students and professionals properly credit the information that they use. Cite your interview in Diabetes & Vascular Disease Research format for free.
Citation Machine™ helps students and professionals properly credit the information that they use. Cite your multivolume work in Diabetes & Vascular Disease Research format for free.
This statistic displays the share of the population suffering from stroke, heart and vascular diseases in Tasmania from 2004 to 2015.
Mesocardia & Normal Electrocardiogram & Vascular Disease Symptom Checker: Possible causes include Corrected Transposition of the Great Vessels. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
​Written by experts in the field Comprehensive approach to geriatric vascular disease Provides a step-by-step guide to surgical techniques
West Chester resident Mary Taylor gets screened for vascular diseases at the UC Heart and Vascular Centers free screening event. is provided by the Society for Vascular Surgery and includes a wealth of information and resourses for Vascular Health Professionals and Vascular Patients
Vascular Health focuses on the care of the circulatory system, which moves blood throughout the body. Arteries carry blood from the heart to vital organs and limbs, and veins return blood back to the heart.
NO SUPPLEMENTS NEEDED..Do you want to look vascular and have great pumps in the gym? This video will give you such 4 products which values under rs 10 and increases your vascularity and pump ... - Natural Health Resource - The worlds most widely referenced, open access, natural medicine database, with 30,000+ study abstracts and growing daily
By default, all articles on are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
If your patient is receiving drug therapy, monitor the effects of the prescribed drugs. Assess the neurovascular status of his legs and report any deterioration in ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Society for Vascular Surgery: Its Never Been More Important to Manage Stress Levels ROSEMONT, Ill., April 20, 2020 - Americans stress levels are through the r
Smoking related pulmonary vascular disease has been demonstrated to be an independent predictor of morbidity and mortality in patients with COPD. Previous inves...
Age equal to or greater than 50 years with established clinical vascular disease, or age equal to or greater than 55 years and subclinical vascular disease or age equal to or greater than 60 years and at least 2 or more cardiovascular risk ...
Vascular studies work by checking the blood flow in the veins and arteries. They are non-invasive in nature as they use ultrasound to measure the amount and the flow in your vessels.
Zhou Lijuan, Yang Wansong, Wang Weiqun, et al. Department of Cardiology, Second hospital of Tianjin Medical University, Tianjin 300211 ...
The vascular exams are performed by Registered Vascular Technologists (RVT) specializing in vascular testing, and consist of various testing options.
Abbott Vascular, a division of Abbott, is a global leader in cardiac and vascular care with market-leading products and an industry-leading pipeline.
Abbott Vascular, a division of Abbott, is a global leader in cardiac and vascular care with market-leading products and an industry-leading pipeline.
Vascular Diseases). Witzstrock, Baden-Baden 1974 (as editor with K. Credner). In the Medline database PubMed, Loogen is listed ... Once his interest in heart disease was aroused - apparently by the endocarditis cases in the prisoner-of-war camp - and he was ... Later, coronary heart disease, cardiomyopathies and electrotherapy (pacemakers) were added. Loogen recognised early on that ... Habilitation thesis) Angeborene Herz- und Gefässfehler (Congenital heart and vascular defects). In: Röntgendiagnostik des ...
Travel Medicine and Infectious Diseases; Urgent Care Center; Urology; Vascular Screenings; Vascular Surgery; Wellness and ... Vascular Screenings; and Vascular Surgery. Livingston, New Jersey. Its 50,000 square-foot medical facility at 75 E. Northfield ... sinus disease and oncology. Its oncology trials include studies for breast cancer, colorectal cancer, leukemia, lung cancer, ...
"Vascular Disease in Systemic Lupus Erythematosus". Autoimmune Diseases. 2012: 876456. doi:10.1155/2012/876456. PMC 3432322. ...
"Vascular Dementia , Signs, Symptoms, & Diagnosis". Retrieved 2016-12-12. "NINDS , Parkinson's Disease Information ... Common areas of practice include loneliness in old age, depression, dementia, Alzheimer's disease, vascular dementia, and ... A geriatric psychologist aids in the assessment, diagnosing, treatment, and research of vascular dementia. Parkinson's disease ... and research of the disease. Vascular dementia, the second most common type of dementia, is the result of a stroke. Often times ...
Salmon JF (13 December 2019). "Retinal vascular disease". Kanski's clinical ophthalmology : a systematic approach (9th ed.). ...
John F., Salmon (2020). "Retinal vascular disease". Kanski's clinical ophthalmology : a systematic approach (9th ed.). ... "WHO , Priority eye diseases". WHO. Retrieved 2020-09-02. Coursey, Terry G; de Paiva, Cintia S (2014-08-04). "Managing Sjögren's ... Diabetic Eye Disease Carraro, Maria Cristina; Rossetti, Luca; Gerli, Gian Carla (October 2001). "Prevalence of retinopathy in ... Sjögren's syndrome, a chronic autoimmune inflammatory disease that destroys moisture producing glands, including lacrimal gland ...
It increases the risk of ischemic heart disease, strokes, peripheral vascular disease, and other cardiovascular diseases, ... Fisher ND, Williams GH (2005). "Hypertensive vascular disease". In Kasper DL, Braunwald E, Fauci AS, et al. (eds.). Harrison's ... For people who have experienced cardiovascular disease or those who are at a 10-year risk of cardiovascular disease of greater ... vascular rupture, and hemorrhagic stroke. Fullness disease was presumed to be due to an excessive amount of blood within the ...
"Terumo Aortic Announces Completion of Enrollment in RelayPro U.S. Pivotal Study". Vascular Disease Management. Retrieved 25 ... he currently serves as Chief of Complex Vascular Services and Network Director of Vascular Services of the HonorHealth hospital ... Venkatesh G. Ramaiah, MD, FACS is a vascular surgeon and researcher. His areas of work include innovations in the treatment of ... He went on to complete a vascular surgery fellowship under renowned surgeon Dr. Edward "Ted" Dietrich at the Arizona Heart ...
Perera GA (1955). "Hypertensive vascular disease; description and natural history". Journal of Chronic Diseases. 1 (1): 33-42. ... is typically transient as the vascular disease tends to resolve and renal perfusion improves over one to three months. ... This level of BP control will allow gradual healing of the necrotizing vascular lesions. More aggressive hypotensive therapy is ... such as stroke or coronary disease). Once the BP is controlled, the person should be switched to medication by mouth, with the ...
He was author of the standard Textbook of vascular medicine, Peripheral Vascular Diseases, first published in 1946, and served ... "Peripheral vascular diseases". Edgar van Nuys Allen along with associates in the Mayo Clinic and Mayo Foundation; 2nd edition, ... Edgar Allen was a specialist in cardiovascular medicine, and particularly known for his research of peripheral vascular disease ... Appio MR, Swan KG (February 2011). "Edgar Van Nuys Allen: The Test Was Only the Beginning". Annals of Vascular Surgery. 25 (2 ...
Peripheral vascular disease; femoral artery stenosis Renal artery stenosis Stroke, carotid artery stenosis Aortic aneurysm ... disease, goitre Paget's disease Polymyalgia rheumatica Giant cell arteritis Fibromuscular dysplasia IgG4-related disease ... Bruit, also called vascular murmur, is the abnormal sound generated by turbulent flow of blood in an artery due to either an ... "bruit" at Dorland's Medical Dictionary "vascular murmur" at Dorland's Medical Dictionary Wolters Kluwer, Stedman's Medical ...
Fisher ND, Williams GH (2005). "Hypertensive vascular disease". In Kasper DL, Braunwald E, Fauci AS, et al. (eds.). Harrison's ...
475). Philadelphia: WB Saunders ISBN 0-7216-9653-8 Creager, M.A. & Dzau, V.J. (2005). Vascular diseases of the extremities. In ... Acrocyanosis may be a sign of a more serious medical problem, such as connective tissue diseases and diseases associated with ... 1490). New York: McGraw-Hill ISBN 0-07-140235-7 (2006). Peripheral vascular disorders. In R.S. Porter, T.V. Jones, & M.H. Beer ... The normal peripheral pulses rule out peripheral arterial occlusive disease, where arterial narrowing limits blood flow to the ...
Mandel J, Taichman D (2006). Pulmonary Vascular Disease. Elsevier Health Sciences. p. 170. ISBN 978-1416022466. Ferri FF (2015 ... Rh disease, one of the causes of hemolytic disease of the newborn Transfusion reaction to blood transfusions Mechanical trauma ... "Sickle Cell Disease". National Heart, Lung, and Blood Institute. Table 12-1 in: Mitchell RS, Kumar V, Abbas AK, Fausto N (2007 ... Inflammatory bowel disease. There are a number of definitions of anemia; reviews provide comparison and contrast of them. A ...
Retinal Vascular Disease. Springer. pp. 430-. ISBN 978-3-540-29541-9. Retrieved 29 June 2010. Conley, C. Lockard (1952). "A ... and only a small proportion will proceed to develop this disease (which causes joint pains, skin problems and kidney failure, ...
Vascular Disease Management. Volume 9 - Issue 7 - July 2012. Volodos NL, Shalimov AA. [Some issues of coronary insufficiency]. ... In 2014, was nominated as Honorary Member by The German Vascular Society. At the same time, he was awarded the Jörg Vollmar ... Volodos was described by his colleagues as "a pioneer innovator and a giant in vascular and endovascular surgery" and "a giant ... In 2016, the European Society for Vascular Surgery (ESVS) commissioned a keynote lecture to be delivered at the Society's ...
Cochrane Peripheral Vascular Diseases Review Group (CS1 errors: generic name, Articles with short description, Short ... Report of a subcommittee of the Joint Council of the American Association for Vascular Surgery and Society for Vascular Surgery ... Diseases of the aorta, Vascular surgery, Deaths from abdominal aortic aneurysm, Wikipedia medicine articles ready to translate ... Vascular Disease Prevention. 6 (1): 114-121. doi:10.2174/1567270001006010114. hdl:10344/184. Kleinstreuer C, Li Z (2006). " ...
Biomarker of vascular disease. Thromb Haemost. 93: 228-235. George, F., Brisson, C., Poncelet, P., Laurent, J.C., Massot, O., ... Disease Markers. 31: 75-82 Davies, M. J., & Thomas, A. C. (1985). Plaque fissuring--the cause of acute myocardial infarction, ... Disease Markers. 31: 75-82 Woywodt, A., Bahlmann, F.H., de Groot, K., Haller, H., Haubitz, M. (2002) Circulating endothelial ... Researchers are hoping that the HD-CEC test will be used to predict cardiovascular diseases such as acute MI, angina and heart ...
"Annual Meeting 2011". Vascular Disease Foundation. Archived from the original on 6 November 2011. Retrieved 11 October 2011. " ... as well as the Vascular Disease Foundation's annual meeting. He spoke on a panel with such writers as Dan Fante and Emma ...
Vascular Disease Research. 11 (3): 133-73. doi:10.1177/1479164114525548. PMID 24800783. Gnesin F, Thuesen AC, Kähler LK, ... Vascular Disease. 7 (5): 247-52. doi:10.1177/14746514070070051001. Dawes GS, Mott JC (March 1950). "Circulatory and respiratory ... Non-alcoholic fatty liver disease Premature puberty Cancer Cardiovascular disease in people with diabetes Aging While metformin ... Metformin is not approved for use in those with severe kidney disease, but may still be used at lower doses in those with ...
II Anastomosis Assist Device for the Proximal Coronary Branch Anastomosis to Vascular Graft". Annals of Vascular Diseases. 3 (1 ... Pathological anastomosis results from trauma or disease and may involve veins, arteries, or intestines. These are usually ...
... coronary artery disease, cerebral vasospasm and diabetic vascular disease. There he worked with Paul M. Vanhoutte and was ... "Diabetes and Vascular Disease". Circulation. 108 (12): 1527-1532. doi:10.1161/01.CIR.0000091257.27563.32. PMID 14504252. S2CID ... He says that COVID-19 is ultimately an endothelial disease and stated that "the concept that the endothelium is the main target ... He has described COVID-19 as ultimately an endothelial disease. In 2021 he addressed one of the most popular heart health ...
November 2014). "Thrombosis: a major contributor to global disease burden". Arteriosclerosis, Thrombosis, and Vascular Biology ... Chronic inflammatory diseases and some autoimmune diseases, such as inflammatory bowel disease, systemic sclerosis, Behçet's ... Annals of Vascular Diseases. 10 (2): 99-106. doi:10.3400/avd.ra.17-00035. PMC 5579784. PMID 29034034. Nicklas JM, Gordon AE, ... a joint consensus document from the European Society of Cardiology working groups of aorta and peripheral vascular diseases and ...
Vascular Disease Research. 4 (3): 194-203. doi:10.3132/dvdr.2007.040. PMID 17907109. S2CID 896195. "GALIDA (tesaglitazar) ...
Manual of Vascular Diseases. Sanjay Rajagopalan, Debabrata Mukherjee, Emile R. Mohler. Lippincott Williams & Wilkins. 2004. p. ... "Chapter 7: Clinical Assessment of Venous Disease". Venous and Lymphatic Diseases. Nicos Labropoulos, Gerard Stansby. Informa ... Vascular, All stub articles, Medical sign stubs). ...
Three types of worm cause the disease and damage the lymphatic system.[citation needed] The disease itself is a result of a ... Gloviczki P (1995). "The management of lymphatic disorders". In Rutherford RB (ed.). Vascular surgery (4th ed.). Philadelphia: ... Lymphatic filariasis is a human disease caused by parasitic worms known as filarial worms. Most cases of the disease have no ... With consistent treatment, since the disease needs a human host, the reduction of microfilariae means the disease will not be ...
John S, Sorokin AV, Thompson PD (February 2007). "Phytosterols and vascular disease". Current Opinion in Lipidology. 18 (1): 35 ... These groups were more likely to die of cancer, liver diseases, and mental diseases with very low total cholesterol, of 186 mg/ ... "Diseases and Conditions. High cholesterol: Olive oil, Foods with added plant sterols or stanols, Other changes to your diet". ... Because cardiovascular disease is relatively rare in the younger population, the impact of high cholesterol on health is larger ...
Patel Manoj D.; Thompson Paul D. (2006). "Phytosterols and Vascular Disease". Atherosclerosis. 186 (1): 12-19. doi:10.1016/j. ...
Vascular Disease Research. 4 (2): 124-29. doi:10.3132/dvdr.2007.030. PMID 17654446. S2CID 23793589. Qamar A, Khetarpal SA, ... Elevations of Apo-CIII found in genetic variation studies may predispose patients to non-alcoholic fatty liver disease. Click ... This may explain the hypertriglyceridemia associated with ABCA1-deficiency in patients with Tangier's disease. GRCh38: Ensembl ... and Vascular Biology. 35 (8): 1880-1888. doi:10.1161/ATVBAHA.115.305415. PMC 4556282. PMID 26069232. Sacks FM, Zheng C, Cohn JS ...
Sanjay Rajagopalan; Debabrata Mukherjee; Emile R. Mohler (31 August 2004). Manual of Vascular Diseases. Lippincott Williams & ... A.R. Genazzani (15 May 2001). Hormone Replacement Therapy and Cardiovascular Disease: The Current Status of Research and ...
Thyroid disease[edit]. Hypothyroidism is the most common thyroid abnormality associated with[vague] PFAS exposure.[39] PFASs ... triglyceride and uric acid levels which may lead to vascular inflammation and elevated blood pressure.[45] ... "Agency for Toxic Substances and Disease Registry (ATSDR)", Health Care Policy and Politics a to Z, CQ Press, 2009, doi:10.4135/ ... Centers for Disease Control. August 22, 2017. Archived (PDF) from the original on October 18, 2020. Retrieved August 13, 2019. ...
Aging and Disease. 2013, 4 (6): 320-28. ISSN 2152-5250. doi:10.14336/AD.2013.0400320.. ... Intermediate Vascular Traits, and All-Cause Mortality. JAMA Cardiology. 14 September 2016, 1: 767. doi:10.1001/jamacardio. ... Disease mongering of age-associated declines in testosterone and growth hormone levels.. Journal of the American Geriatrics ... Tersigni C, Castellani R, de Waure C, Fattorossi A, De Spirito M, Gasbarrini A, Scambia G, Di Simone N. Celiac disease and ...
"Bulletin of the NYU Hospital for Joint Diseases. 67 (2): 198-205. PMID 19583554. Archived from the original on 1 June 2013.. ... "Annals of the Rheumatic Diseases. 81: ard-2022-223016. doi:10.1136/ard-2022-223016. ISSN 1468-2060. PMID 35961760.. ... Medicine has a long history of scientific inquiry about the prevention, diagnosis, and treatment of human disease.[3][4] ... and co-morbid diseases), evidence from RCTs may not be generalizable to those populations.[77] Thus, EBM applies to groups of ...
Role in disease[edit]. IL-6 stimulates the inflammatory and auto-immune processes in many diseases such as multiple sclerosis,[ ... regulation of vascular endothelial growth factor production. *positive regulation of chemokine production ... Diseases[edit]. Enterovirus 71[edit]. High IL-6 levels are associated with the development of encephalitis in children and ... "Changes in biomarkers focused on differences in disease course or treatment in patients with neuro-Behçet's disease". Internal ...
Vascular endothelial stem cells have been defined as rare endothelial colony forming cells with extremely high proliferative ... ECFCs have been shown to decline in number and clonal ability with age or peripheral arterial disease, though are increased ... A New Highly Characterized Research Reagent to Study the Formation of Emergent Vascular Structures Both In Vitro and In Vivo". ... They are thought to play a critical role in vascular healing after injury as well as developmental angiogenesis. ...
Pulmonary vascular diseases *Acute or recurrent pulmonary emboli. *Pulmonary hypertension, primary or secondary ... Diseases of lung parenchyma and pleura *Contagious *Anthrax through inhalation of Bacillus anthracis ...
Vascular plantsEdit. Cavitation can occur in the xylem of vascular plants.[49][50] The sap vaporizes locally so that either the ... "Annals of the Rheumatic Diseases. 30 (4): 348-58. doi:10.1136/ard.30.4.348. PMC 1005793. PMID 5557778.. ... Inertial cavitation occurs in nature in the strikes of mantis shrimps and pistol shrimps, as well as in the vascular tissues of ... Cavitation plays a key role in non-thermal, non-invasive fractionation of tissue for treatment of a variety of diseases[19] and ...
"International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) Version for 2010. World ... Vascular tumors such as hemangiomas and lymphangiomas (formed from blood or lymph vessels) are thus looked at as being amalgams ... "DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture". Mol. Cancer Res. 6 (4 ...
International Review of Thoracic Diseases. 67 (1): 18-23. doi:10.1159/000029457. PMID 10705257. S2CID 45667293.. ... vascular endothelial growth factor) from the platelet-rich blood clots. The excessive interstitial lung fluid traverses the ... autoimmune disease such as systemic lupus erythematosus, bleeding (often due to chest trauma), chylothorax (most commonly ... but an accurate diagnosis of the disease that produces the fluid.[27] The traditional definitions of transudate as a pleural ...
... heart disease, vascular disease, lung disease, and so on. ... it will be healthier in the future and diseases resulting from ... for this measure to have a real impact on obesity and cardiovascular disease. Countries that already have specific taxes on ...
Huntington's disease. *Mild cognitive impairment. *পারকিনসন রোগ. *Pick's disease. *Sundowning. *Vascular dementia ...
പഠനം, വിശകലനം തുടങ്ങിയവയിലൂടെ മനുഷ്യന്റെ ആരോഗ്യം പരിപാലിക്കുകയും നിലനിർത്തുകയും രോഗബാധ തടയുകയും ചെയ്യുന്നതിനെയാണ് വൈദ്യം(മരുന്ന്) എന്ന് പറയുന്നത്. വൈദ്യത്തിന്റെ പരമമായ ലക്ഷ്യം മരണത്തെ രോഗിയിൽ നിന്ന് മാറ്റിനിർത്തുക എന്നതാണ്. പ്രകൃതിയിൽ നിന്നും ലഭ്യമായ ചെടികളും മറ്റും ഉപയോഗിച്ചാണ് പ്രാചീനമനുഷ്യർ ചികിത്സ നടത്തിയിരുന്നത്. വർഷങ്ങളായി കൈമാറ്റപ്പെട്ട അറിവുകൾ ...
Brain Aβ is elevated in people with sporadic Alzheimer's disease. Aβ is the main constituent of brain parenchymal and vascular ... Citron M (September 2004). "Strategies for disease modification in Alzheimer's disease". Nature Reviews. Neuroscience. 5 (9): ... Further information: Alzheimer's disease § Research directions. Researchers in Alzheimer's disease have identified several ... "Differences between vascular and plaque core amyloid in Alzheimer's disease". Journal of Neurochemistry. 51 (2): 648-51. doi: ...
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. The American ... Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ (BMJ). 2008-01-15, ... Archives of Disease in Childhood. 1973, 48 (10): 814-6. PMC 1648552 . PMID 4542997. doi:10.1136/adc.48.10.814.. ... Archives of Disease in Childhood. 2007, 92 (12): 1088-93 / 1088. PMC 2066069 . PMID 17768148. doi:10.1136/adc.2006.112813.. ...
... a targeted anti-VEGF aptamer for ocular vascular disease". Nat Rev Drug Discov 5 (2): 123-32. DOI:10.1038/nrd1955. PMID ...
L. McCance, Kathryn; Huether, Sue E. (2018). Pathophysiology - E-Book: The Biologic Basis for Disease in Adults and Children. ... Widrich, J; Shetty, M (March 2021). "Physiology, Pulmonary Vascular Resistance". StatPearls Publishing. PMID 32119267.. ... the importance of the heart and its connection to vessels throughout the body and described methods to detect cardiac disease ...
Genetic and Rare Diseases Information Center «Roussy Levy syndrome» (en anglès). GARD/NIH. Diseases, 2017, Feb 2, pàgs: 7 [ ... Aquestes funcions modulables inclouen la vasomotricitat (és a dir, la constricció i dilatació vascular perifèrica), la ... Choi, BO; Kim, SB; Kanwal, S; Hyun, YS; et al «MPZ mutation in an early-onset Charcot-Marie-Tooth disease type 1B family by ... Principals tipus de neuropaties hereditàries motores i sensorials, amb enllaç a l'OMIM i a la Diseases Database:[106] ...
The single, most common cause of traumatic death in youth baseball". American Journal of Diseases of Children. 145 (11): 1279- ... vascular: Traumatic aortic rupture *Thoracic aorta injury. *heart: Myocardial contusion/Commotio cordis ... and not the result of heart disease. The survival rate is 58%, which is an increase in comparison to years 1993-2012, where ...
Knight J (1998). "Free radicals: their history and current status in aging and disease". Ann Clin Lab Sci. 28 (6): 331-46. PMID ... "Oxidative stress and diabetic vascular complications". Diabetes Care. 19 (3): 257-67. doi:10.2337/diacare.19.3.257. PMID ... Cookson M; Shaw P (1999). "Oxidative stress and motor neurone disease". Brain Pathol. 9 (1): 165-86. PMID 9989458.. ... 2006). "Involvement of oxidative stress in Alzheimer disease". J Neuropathol Exp Neurol. 65 (7): 631-41. doi:10.1097/01.jnen. ...
Some glycation product are implicated in many age-related chronic diseases, including cardiovascular diseases (the endothelium ... Soldatos, G.; Cooper ME (Dec 2006). "Advanced glycation end products and vascular structure and function". Curr Hypertens Rep. ... "Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1360 (1): 17-29. doi:10.1016/S0925-4439(96)00062-2. PMID ... Vlassara H (June 2005). "Advanced glycation in health and disease: role of the modern environment". Annals of the New York ...
Di Carlo A, Baldereschi M, Amaducci L. Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy. The ILSA ... 當疾病逐漸惡化,各式病症也會逐漸出現如口腔或牙科疾病(英语:dental disease)、褥瘡、營養不良、衛生問題、呼吸道感染」皮膚感染、眼感染等。小心的照護管理能避免上述問題產生,但若真的發生了,則需要專業的治療[218][219]。在疾病的最末期, ... 根據雙胞胎和家族
The disease is the cause of the COVID-19 pandemic.[10][11] People who get the disease might get fever, dry cough, fatigue ( ... "Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19". New England Journal of Medicine. 383 (2): 120- ... Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS coronavirus 2 (SARS-CoV-2),[6] a virus closely ... "Coronavirus Disease 2019 (COVID-19)-Transmission". Centers for Disease Control and Prevention. April 2, 2020. Archived from the ...
Diseases of the urinary system (N00-N39, 580-599). Kidney disease. Glomerules. ... Vascular. *Renal artery stenosis. *Renal ischemia. *Hypertensive nephropathy. *Renovascular hypertension. *Renal cortical ...
Shute EV, Vogelsang AB (January 1948). "The influence of vitamin E on vascular disease". Surgery, Gynecology & Obstetrics. 86 ( ... Parkinson's disease[edit]. For Parkinson's disease, there is an observed inverse correlation seen with dietary vitamin E, but ... "Vitamin e in Health and Disease - Interactions, Diseases and Health Aspects. Biochemistry. Vol. 22. doi:10.5772/intechopen. ... which enrolled people with pre-existing vascular disease or diabetes into a multi-year trial of 400 IU/day, reported a higher ...
In 2021, the principal cause of death among Malaysian adults was coronary artery disease, representing 17% of the medically ... There are an estimated 8,500 species of vascular plants in Peninsular Malaysia, with another 15,000 in the East.[178] The ...
... as input can aid vascular physicians to decide with higher confidence on best suitable treatment for cardiovascular disease ... coronary artery disease, congenital heart defect, pathological brain detection, fracture detection, Alzheimer's disease, and ... Alzheimer's disease[edit]. CADs can be used to identify subjects with Alzheimer's and mild cognitive impairment from normal ... Cardiovascular disease[edit]. State-of-the-art methods in cardiovascular computing, cardiovascular informatics, and ...
Graft-versus-host disease is an auto- and alloimmune disorder, exhibiting a variable clinical course. It can manifest in either ... These include immune response, foreign body reaction with the isolation of the implant with a vascular connective tissue, ... "Deformation and failure of protein materials in physiologically extreme conditions and disease". Nature Materials. 8 (3): 175- ...
Disease, Medicine and Society in England, 1550-1860 (Cambridge University Press, 1995). ... Physicians may focus their practice on certain disease categories, types of patients, and methods of treatment-known as ... Causes of death which are less likely to occur in physicians than the general population include respiratory disease (including ... Primary care physicians guide patients in preventing disease and detecting health problems early while they are still treatable ...
ಜೀನ್-ಆಂಡ್ರೆ ವೆನೆಲ್ ೧೭೮೦ ರಲ್ಲಿ ಮೊದಲ ಮೂಳೆ ಶಸ್ತ್ರಚಿಕಿತ್ಸಾ ಸಂಸ್ಥೆಯನ್ನು ಸ್ಥಾಪಿಸಿದರು. ಇದು ಮಕ್ಕಳ ಎಲುಬಿನ ವಿಕಾರತೆಗಳಿಗೆ ಚಿಕೆತ್ಸೆ ನೀಡಿದ ಮೊದಲ ಆಸ್ಪತ್ರೆಯಾಯಿತು. ಇವರನ್ನು ಕೆಲವರು ಅಸ್ಥಿಚಿಕಿತ್ಸೆಯ ಪಿತಾಮಹನೆಂದು ಪರಿಗಣಿಸುತ್ತಾರೆ, ಅಥವಾ ಅವರ ಆಸ್ಪತ್ರೆಯ ಸ್ಥಾಪನೆಯಿಂದಾಗಿ ಮತ್ತು ಪ್ರಕಟಿಸಲಾದ ಅವರ ವಿಧಾನದಿಂದಾಗಿ ಅವರನ್ನು ಮೊದಲ ನಿಜವಾದ ಅಸ್ಥಿಚಿಕಿತ್ಸಜ್ಞ ಎಂದು ಪರಿಗಣಿಸುತ್ತಾರೆ.[ಸೂಕ್ತ ಉಲ್ಲೇಖನ ಬೇಕು] ಆಂಟೊನಿಯಸ್ ...
"Centers for Disease Control and Prevention. Centers for Disease Control and Prevention. 17 June 2020. Retrieved 22 November ... Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin ... Arthritis is predominantly a disease of the elderly, but children can also be affected by the disease.[99] Arthritis is more ... "Lyme Disease". The Lecturio Medical Concept Library. Retrieved 22 August 2021.. *^ "What Is Sjögren's Syndrome? Fast Facts". ...
Your vascular system is made up of blood vessels that carry blood to and from the heart. Learn about vascular diseases and ... What causes vascular diseases?. The causes of vascular diseases depend on the specific disease. These causes include:. * ... Who is at risk for vascular diseases?. The risk factors for vascular diseases can vary, depending on the specific disease. But ... How are vascular diseases treated?. Which treatment you get depends on which vascular disease you have and how severe it is. ...
... including both neurodegenerative diseases and vascular disease. Dementia is most common in elderly individuals, with advancing ... Comorbid Disease. Alzheimer disease (AD), vascular brain injury (VBI), and Lewy body disease (LBD) are all highly prevalent ... 14] Most vascular dementia cases are sporadic and share risk factors with peripheral vascular disease. ... Multiple neuropathologic processes may underlie dementia, including both neurodegenerative diseases and vascular disease. [1] ...
Peripheral vascular disease (PVD) is a nearly pandemic condition that has the potential to cause loss of limb or even loss of ... encoded search term (Peripheral Vascular Disease) and Peripheral Vascular Disease What to Read Next on Medscape ... Long-term cardiovascular outcomes following ischemic heart disease in patients with and without peripheral vascular disease. ... Peripheral Vascular Disease Clinical Presentation. Updated: May 24, 2022 * Author: Everett Stephens, MD; Chief Editor: Erik D ...
Pulmonary Vascular Diseases Program Pulmonary hypertension is a condition where high pressure in the blood vessels within the ... Clinically, his main interests are the care of patients with pulmonary hypertension and autoimmune-related lung disease. ... Her academic and clinical interests include medical education, interstitial lung disease, and sarcoidosis. During her free time ... communicative and individualized care to patients and their families as they navigate through the disease course. She feels ...
... heart diseases, HLBS-PopOmics, lung diseases, public health genomics knowledge base, sleep disorders, vascular diseases ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... vascular diseases - Genomics and Precision Health Blog ...
Peripheral Vascular Disease. Learn more about Peripheral artery disease conditions, from managing risk factors and prevention ... Treatment of Venous Disease Including Care During COVID-19. Venous disease refers to disorders of the veins and can include ... Peripheral Artery Disease - A Serious Condition You May Have Never Heard About. Learn more about Peripheral Artery Disease (PAD ... Managing Vascular Conditions During COVID-19. Learn more about maintaining your vascular health at home, warning signs that ...
Unknown author (‎1988)‎. Acetylsalicylic acid in vascular disease. WHO drug information 1988 ; 2(‎3)‎ : 125-127 https:// ...
A new report estimates that nearly half of all U.S. adults have some form of heart or blood vessel disease, a medical milestone ... Nearly half of US adults have heart or blood vessel disease. By MARILYNN MARCHIONEJanuary 31, 2019 GMT ...
One key measure is achieving optimal vascular care for patients with vascular disease, a form of cardiovascular disease that ... One key measure is achieving optimal vascular care for patients with vascular disease, a form of cardiovascular disease that ... control of vascular disease risk factors on heart disease mortality in Minnesota communities. In particular, the Minnesota ... examining the patterns of vascular disease risk factor management and heart disease mortality among urban, suburban, small ...
Thoracic Institute has created a series of online videos to provide you with information about vascular disease & treatments. ... Vascular Disease & Treatments Videos Vascular Disease & Treatments Videos The Miller Family Heart, Vascular & Thoracic ... These videos highlight questions and answers about vascular disease and treatments by our health care professionals. ... Carotid Artery Disease: FAQ, Drs. Lyden, Cameron, and Bajzer. *Peripheral Artery Disease (PAD) in the Diabetic Population, ...
What are the symptoms of renal vascular disease?. Symptoms of renal vascular disease vary depending on the type of disease and ... What is renal vascular disease?. Renal vascular disease is the name given to a variety of complications that affect the ... Symptoms of various types of renal vascular disease include, but are not limited to, the following:. Type of Renal Vascular ... Atheroembolic renal disease. Treatment of atheroembolic renal disease depends on the extent of the disease and the individual ...
Diabetic arterial or vascular disease can cause leg pain and other complications. Read about the surgical and non-surgical ... Diabetic arterial disease risks. Factors that can increase your risk for diabetic vascular disease include:. *How long you have ... Vascular surgeons at the UPMC Heart and Vascular Institute treat more than 1,000 people with diabetic arterial disease each ... What Is Diabetic Arterial Disease?. People with diabetes are at much greater risk for heart and vascular disease compared to ...
Eye provides clues to insidious vascular disease Eye provides clues to insidious vascular disease Study by the University of ... Using self-learning software, they were able to identify vascular changes in patients with peripheral arterial disease (PAD), ... "In more than half of them, the disease was still at a stage where it did not cause any symptoms." In addition, the team took ... In addition, the risk of a fatal heart attack or stroke is significantly increased - even in the early stages of the disease." ...
Summit Health is offering vascular disease seminars at various locations during the month of... ...
Spinal vascular malformations include several distinct disorders involving an abnormal connection between arteries and veins ... Symptoms of spinal vascular malformations vary depending on the type of vascular problem and the level(s) of the spinal cord ... Surgery or embolization for spinal vascular malformations disease is best performed at specialized cerebrovascular centers like ... How are spinal vascular malformations diagnosed? The diagnosis of a spinal vascular malformation is typically first suspected ...
Pravastatin given for 3 years reduced the risk of coronary disease in elderly individuals. PROSPER therefore extends to elderly ... Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial Lancet. 2002 Nov 23;360 ... vascular disease to pravastatin (40 mg per day; n=2891) or placebo (n=2913). Baseline cholesterol concentrations ranged from ... Mortality from coronary disease fell by 24% (p=0.043) in the pravastatin group. Pravastatin had no significant effect on ...
Offering pulmonary vascular disease patients the latest in diagnostics, prevention, and treatment is at the forefront of the ...
Find a vascular disease team that evaluates your vascular condition and deliver state-of-the-art diagnoses and innovative ... Learn more about heart and vascular disease. New bioprosthetic venous valve offers hope for patients suffering from chronic ... UChicago Medicines Digestive Diseases and Heart & Vascular centers earn high marks on Newsweeks 2023 Worlds Best Specialized ... In order to provide the highest level of care for vascular and aortic conditions, we have a multidisciplinary team of experts ...
Vascular disease is often misunderstood by the general public, as it encompasses several different types of conditions that ... causes Vascular diseaselaser therapySclerotherapysignsTreatmentVaricose VeinsVascular disease ... Diseases of the veins, lymphatics, and arteries are included in vascular conditions that are all in some form connected to the ... As National Vascular Disease Awareness Month takes place this September, it is helpful to know what can be done to recognize ...
Explore our extensive video archive to find videos that inspire and enlighten ...
Search on Castle Connolly for top doctors that specialize in Diabetic Vascular Disease near me . Find up-to-date information ... Find doctors that specialize in Diabetic Vascular Disease near me Castle Connolly Top s in and near There are 2 results that ...
Peripheral vascular disease (PVD) is a nearly pandemic condition that has the potential to cause loss of limb or even loss of ... encoded search term (Peripheral Vascular Disease) and Peripheral Vascular Disease What to Read Next on Medscape ... Long-term cardiovascular outcomes following ischemic heart disease in patients with and without peripheral vascular disease. ... Peripheral vascular disease (PVD) is a nearly pandemic condition that has the potential to cause loss of limb or even loss of ...
... Clark, Alys ; Burrowes, Kelly ; Tawhai, ... It is becoming increasingly apparent that personalized therapies are key to successful management of pulmonary vascular disease ... a means to link investigations across the spectrum from cellular mechanisms to potential improvements in pulmonary vascular ...
Skin and Soft Tissue Infections and Vascular Disease among Drug Users, England. Emerging Infectious Diseases. 2007;13(10):1510- ... Skin and Soft Tissue Infections and Vascular Disease among Drug Users, England. Emerging Infectious Diseases, 13(10), 1510-1511 ... To the Editor: The injecting of illicit drugs is associated with skin and soft tissue infections (SSTIs) and vascular disease ( ... Skin and Soft Tissue Infections and Vascular Disease among Drug Users, England On This Page ...
Skin and Soft Tissue Infections and Vascular Disease among Drug Users, England Charles Irish*. , Roy Maxwell†‡, Mark Dancox‡, ... Skin and Soft Tissue Infections and Vascular Disease among Drug Users, England. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ...
... role for TWIST1 gene expression in vascular disease risk, new Campylobacter species, and more. ... PLOS Papers Look at Vascular Disease Risk, Campylobacter in Cattle, Ovarian Cancer-Associated Microbes Jan 13, 2020 ... and Sweden report on a possible role for TWIST1 gene expression in vascular disease risk. To more fully characterize variants ... For example, the authors found that a coronary artery disease risk SNP on chromosome 7 seemed to influence the expression of ...
The HLVI Center for Rare Cardiovascular Diseases and Conditions is committed to establishing a strong foundation for research, ... Institutes & Centers / Heart, Lung and Vascular Institute / Centers & Programs / Rare Diseases / Conditions ... Center for Rare Diseases and Conditions. About Our Program. While there are cardiovascular and pulmonary-related diseases and ... Autoimmune Disease of the Heart and Blood Vessels. *Genetic Diseases of the Heart and Blood Vessels (classified and ...
The Pulmonary Vascular Disease Learning Pathway at ACC.23/WCC features a collection of pulmonary hypertension (PH) sessions for ... Take part in the Pulmonary Vascular Disease Learning Pathway for these exciting, informative sessions and more! ... determining the severity of the disease, indications for referral to a PH center and initial medication selection (Session 632 ... Home , Plan Your Program , Learning Pathways , Pulmonary Vascular Disease Pulmonary Vascular Disease ...
... we treat a wide range of vascular conditions using the latest technology and advanced procedures. ... Vascular Disease Treatments & Procedures in Los Angeles. Diagnosis and testing. *Carotid duplex scan ... Vascular Care. * Vascular Disease Diagnosis & Tests * Vascular Disease Prevention & Wellness * Vascular Disease Treatments & ...
  • Coronary artery disease and carotid artery disease , diseases that involve the narrowing or blockage of an artery. (
  • Other conditions that often coexist with PVD are coronary artery disease (CAD), atrial fibrillation , cerebrovascular disease, and renal disease. (
  • To more fully characterize variants implicated in past genome-wide association studies of coronary artery disease and other vascular conditions, the team did deep RNA sequencing on genotyped vascular endothelial and coronary artery smooth muscle tissues, searching for cell-type-specific expression quantitative loci, alternative splicing, and other regulatory features that might explain the risk SNP associations. (
  • For example, the authors found that a coronary artery disease risk SNP on chromosome 7 seemed to influence the expression of TWIST1 - a gene with an apparent role in smooth muscle features - while additional risk SNPs coincided with distinct splicing or allele-specific expression profiles for still other genes. (
  • The death certificate, completed by the county chief deputy coroner, and the autopsy report, completed by the pathologist, listed "cardiac dysrhythmia due to atherosclerotic coronary artery disease and myocardial bridging of anterior descending coronary artery" as the cause of death. (
  • Aims During the progression of Alzheimer's disease (AD), recognisable impairments in the vasculature are considered to be confined to the brain and occur solely as a consequence of the neuropathology associated with the disease. (
  • Late-life depression may increase the risk of incident dementia, in particular of Alzheimer's disease and vascular dementia. (
  • To conduct a systematic review and meta-analysis to evaluate the risk of incident all-cause dementia, Alzheimer's disease and vascular dementia in individuals with late-life depression in population-based prospective studies. (
  • We used the generic inverse variance method with a random-effects model to calculate the pooled risk of dementia, Alzheimer's disease and vascular dementia in older adults with late-life depression. (
  • Subgroup analysis, based on five studies, showed that the risk of vascular dementia was significantly higher than for Alzheimer's disease (P=0.03). (
  • Late-life depression is associated with an increased risk for all-cause dementia, vascular dementia and Alzheimer's disease. (
  • The present results suggest that it will be valuable to design clinical trials to investigate the effect of late-life depression prevention on risk of dementia, in particular vascular dementia and Alzheimer's disease. (
  • Heart failure and late-onset Alzheimer's disease: a Mendelian randomization study. (
  • Some observational studies suggested that heart failure (HF) is associated with increased risk of late-onset Alzheimer's disease (AD). (
  • Alzheimer's Disease Related Dementias (ADRD). (
  • Repeated occurrences of microvascular ischemia reportedly lead to white matter hyperintensities, focal brain infarcts, and brain atrophy that contribute to cognitive impairment and the risk of mild cognitive impairment (MCI) and Alzheimer's disease-related dementias. (
  • The purpose of this initiative is to increase the number of early stage physician-scientists in Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) research and improve patient care for veterans. (
  • Alzheimer's disease related dementias (ADRD): Includes frontotemporal dementia (FTD), Lewy body dementia (LBD), vascular cognitive impairment/dementia (VCID), and mixed etiology dementias (MEDs). (
  • Differentiate the symptoms and etiology of the most common late onset disorders, including Alzheimer's disease, Parkinson's disease, Pick's disease, and vascular dementia. (
  • Our current neuroscience clinical trials focus on research for Alzheimer's and dementia, stroke, Parkinson's disease, spinal cord injury and traumatic brain injury. (
  • Alzheimer's Disease: Unraveling the Tangle Indiana specialists discuss advances that enable earlier diagnosis of Alzheimer's disease as well as new drugs targeting cognitive changes and which patients will benefit most from approved therapies. (
  • Cardiologists Jag Singh and Jared Bunch discuss the link between atrial fibrillation and cognitive dysfunction, including vascular dementia and Alzheimer's disease. (
  • Alzheimer's Disease: Anti-Amyloid Therapies: Risks and Potential Experts at the Butler Hospital discuss the risks for amyloid-related imaging abnormalities with aducanumab and other promising anti-amyloid therapies. (
  • Alzheimer's Disease: Hope on the Horizon: When Progress Is the Enemy Experts discuss patient evaluation for the use of aducanumab and the importance of initiating therapy early in cognitive decline. (
  • The Prevention of Alzheimer's Won't Come in a Pill Bottle A neuroscientist is frustrated with the focus on a magic pill to cure Alzheimer's disease but sees hope in the findings of recent studies on multimodal approaches that include brain training. (
  • Key Abstracts in Dementia Science From AAIC 2022 Key abstracts from AAIC 2022, as reported by Dr Michael Rafii, focus on crenezumab in autosomal dominant Alzheimer's disease and AD biomarkers in diabetes, Down syndrome, and persons with poor sleep. (
  • Despite obesity and diabetes markedly increasing the risk of developing cardiovascular diseases, the molecular and cellular mechanisms that underlie this association remain poorly characterised. (
  • Furthermore, increased vascular pro-inflammatory signalling is a key event in the development of cardiovascular diseases. (
  • 2.7 Health Research In Cardiovascular Diseases. (
  • These included, the rapid transmission of communicable diseases, preventing noncommunicable diseases like cardiovascular diseases which were the major cause of death and protecting environmental health issues like arsenic poisoning. (
  • This is important in the treatment of cardiovascular diseases in the aging population. (
  • Hypertension is an important public health problem and one of the leading risk factors for morbidity and mortality from cardiovascular diseases. (
  • Hypertension is the most common cause of primary care visits, and it is an independent and a reversible risk factor for cardiovascular diseases (CVDs) such as myocardial infarction, stroke and renal failure. (
  • Learn more about a unique cardiometabolic program that integrates care for diabetes and heart disease which are overlapping conditions. (
  • High cholesterol, diabetes, being overweight, and having a family history of cardiovascular disease are also risk factors for RAS. (
  • People with diabetes face special health challenges, including an increased risk for cardiovascular conditions such as diabetic arterial or diabetic vascular disease. (
  • People with diabetes are at much greater risk for heart and vascular disease compared to people who do not have diabetes. (
  • People with diabetes are more likely to have a heart attack or stroke, or experience kidney disease. (
  • In addition, these findings have led the Heart Disease and Stroke Prevention Unit to seek optimal vascular care and optimal diabetes care measure data for additional years, both at the clinic level and by the patient's residence. (
  • Older age, diabetes, hypertension and vascular disease are among the risk factors for RVO. (
  • Endothelial cell dysfunction,vascular smooth muscle cell dysfunction, inflammation,impaired platelet function and abnormal coagulation are theother key factors in progression of PVD in diabetes. (
  • Those patients in whom peripheral vascular disease (PVD) becomes significant, however, often have a plethora of comorbid medical conditions, such as cardiovascular disease, diabetes, and chronic obstructive pulmonary disease, which increase procedural morbidity and mortality. (
  • The aim of this study was to assess if menaquinone supplementation, compared to placebo, decreases vascular calcification in people with type 2 diabetes and known CVD. (
  • Her past medical history was significant for peripheral vascular disease (PVD), diabetes, myocardial infarction with percutaneous intervention, and ischemic cardiomyopathy. (
  • Despite the advent of effective antiviral drugs to eradicate hepatitis C infection, the prevalence of HCC is projected to increase secondary to increasing rates of fatty liver disease from diabetes and the obesity epidemic [ 2 ]. (
  • Learn more about Peripheral artery disease conditions, from managing risk factors and prevention to the latest diagnosis and treatment options. (
  • In order to provide the highest level of care for vascular and aortic conditions, we have a multidisciplinary team of experts who collaborate across specialties to provide comprehensive evaluation, diagnosis and treatment. (
  • The HLVI Center for Rare Diseases and Conditions is committed to establishing a strong foundation for research, diagnosis and treatment of the most complex, rare conditions of the heart, and lungs, and vascular system. (
  • Learn more about aortic disease diagnosis and aortic disease treatments available at Henry Ford. (
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (
  • However, circulating oxidative stress markers and bioactive lipid mediators did not significantly differ according to the autosomal dominant polycystic kidney disease diagnosis. (
  • Diagnosis codes are based on the International Classification of Diseases (ICD) system. (
  • Diagnosed or Treated Age-related macular degeneration (AMD) includes diagnosis codes specifying degenerative diseases of the macula, including macula drusen, dry-form AMD (including geographic atrophy), and wet-form AMD (including active choroidal neovascularization). (
  • Atherosclerosis - a disease in which plaque builds up inside your arteries. (
  • Renal vascular disease is the name given to a variety of complications that affect the arteries and veins of the kidneys. (
  • Atheroembolic renal disease occurs when a piece of plaque from the aorta and/or other large arteries breaks off and travels through the bloodstream, blocking small arteries such as the renal arteries. (
  • Formation of a thrombosis (clot) inside one of the renal arteries may occur as a result of trauma, infection, inflammatory disease, renal artery aneurysm, renal cell cancer, or fibromuscular dysplasia. (
  • Diabetic arterial disease typically affects smaller arteries - including those that lead to the eyes, kidneys, fingers, feet, and toes - causing nerve and circulation problems. (
  • Spinal vascular malformations include several distinct disorders involving an abnormal connection between arteries and veins around the spinal cord. (
  • Diseases of the veins, lymphatics, and arteries are included in vascular conditions that are all in some form connected to the flow of blood. (
  • Similar to peripheral artery disease, carotid artery disease occurs when arteries become blocked by fatty deposits, or plaques. (
  • We used arteries from CKD mice infected with vascular smooth muscle cell-targeted (VSMC-targeted) adeno-associated virus encoding alkB homolog 1 (Alkbh1) gene or Alkbh1 shRNA to evaluate features of calcification. (
  • Vascular disease occurs when the blood vessels, arteries or veins that carry blood to and from your heart experience problems, such as buildup that restricts the flow of blood. (
  • Vascular endothelial dysfunction, most commonly assessed as impaired endothelium-dependent dilation, and stiffening of the large elastic arteries, typically assessed as carotid-femoral pulse-wave velocity (PWV), are two of the greatest contributors to dysfunction and disorders of arteries ( 6 ). (
  • Peripheral artery disease is a common circulatory problem in which narrowed arteries reduce blood flow to your limbs. (
  • Peripheral artery disease is also likely to be a sign of a more widespread accumulation of fatty deposits in your arteries (atherosclerosis). (
  • Vascular disease occurs when arteries become narrow or clogged, reducing blood flow. (
  • Atherosclerosis can affect all arteries of the body, including those in the brain or carotid arteries causing stroke, in the heart causing myocardial infarction or heart attack and in the legs or arms causing peripheral vascular disease. (
  • Peripheral Arterial Disease (PAD) is a chronic progressive debilitating disease of the arteries in the legs that may cause symptoms ranging from cramping while walking to severe ulceration requiring amputation of toes, feet or an entire leg. (
  • Vascular calcification occurs in both the intima and the media of arteries, and there is evidence that these two sites of calcification are distinct entities (table 1 ). (
  • After the vascular surgery that may have saved his limbs, Dick was ready to get back to planning his flower garden. (
  • Stents or surgery - more advanced disease may require surgery to remove the plaque (carotid endarterectomy), and possibly a stent to keep the artery open. (
  • If vascular disease is detected, further testing, angioplasty or surgery may be needed. (
  • Venous disease refers to disorders of the veins and can include deep vein thrombosis (DVT, or "blood clots"), varicose or spider veins, chronic venous insufficiency and leg ulcers. (
  • While there are cardiovascular and pulmonary-related diseases and conditions that are common and highly prevalent in the United States, there are also an increasing number of previously considered rare disorders requiring attention. (
  • Using the International Classification of Diseases, 10th revision (ICD-10) codes F11-16, F18, and, F19, we identified drug users by a record in any diagnostic field of mental and behavioral disorders due to psychoactive substances, excluding alcohol and tobacco. (
  • Further information about such conditions can be found at Annex A. This guidance therefore seeks to address a span of conditions which comprise disorders, disabilities, impairments, injuries and diseases, which relate both to the brain and the mind. (
  • Eur J Clin Nutr 2021 Nov 29 - 'Vascular calcification is one of the most prevalent disorders in pediatric hemodialysis patients that eventually lead to cardiovascular morbidity. (
  • The impact of vitamin K2 and native vitamin D supplementation on vascular calcification in pediatric patients on regular hemodialysis. (
  • Australian Institute of Health and Welfare (2021) Heart, stroke and vascular disease-Australian facts , AIHW, Australian Government, accessed 04 December 2022. (
  • Attenuating effect of magnesium on pulmonary arterial calcification in rodent models of pulmonary hypertension - J Hypertens 2022 Oct 1 - 'Vascular calcification has been considered as a potential therapeutic target in pulmonary hypertension. (
  • Carotid Artery Disease: Common Questions and Answers with Drs. Kirksey, Campbell and Smolock. (
  • Atherosclerosis can lead to other complications and artery disease types such as peripheral artery disease, carotid artery disease, or aneurysms. (
  • There are no symptoms of carotid artery disease, but the blockages can lead to a stroke. (
  • Carotid artery disease is a narrowing of the carotid artery due to a buildup of plaque. (
  • Left unmanaged, carotid artery disease can lead to a stroke. (
  • Carotid artery disease often has no symptoms, and the condition may go unnoticed until a stroke occurs. (
  • If you have a family history of carotid artery disease, it is important to see a physician to further evaluate your risk factors, monitor your condition and determine the best course of action. (
  • Treatment for carotid artery disease focuses on lifestyle changes, medication and procedures when needed. (
  • however, in settings such as acute limb ischemia, this latent disease can suddenly become life-threatening and necessitate emergency intervention to minimize morbidity and mortality. (
  • Impact of sex on morbidity and mortality rates after lower extremity interventions for peripheral arterial disease: observations from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium. (
  • Vascular calcification (VC) predicts cardiovascular morbidity and mortality in chronic kidney disease (CKD). (
  • The limited regenerative capacity of the heart is a major factor in morbidity and mortality rates: Heart malformation is the most frequent form of human birth defects, and cardiovascular disease is the leading cause of death worldwide. (
  • Aortic disease can affect blood vessels supplying major organs such as your brain and heart. (
  • In fact, we are one of only two hospitals in southeast Michigan offering a team of experts and care program dedicated to aortic disease. (
  • We offer both minimally invasive and open surgical procedures for our aortic disease treatments . (
  • This buildup can lead to varicose veins or more serious conditions including abdominal aortic aneurysm (AAA), c arotid artery disease (CAD), d eep vein thrombosis (DVT), p eripheral artery disease (PAD) or stroke. (
  • The American Heart Association has awarded a UK and Baylor University research partnership $3.7 million to study aortic disease. (
  • The grant will underwrite the work of the UK-BCM Aortopathy Research Center (UK-BCM ARC), which will focus on the impact of sex differences related to aortic diseases. (
  • Aortic disease can cause the expansion and rupture of a vessel wall in the chest or abdominal area, leading to potentially deadly internal bleeding. (
  • The work of the UK-BCM brings together two institutes that have established records of innovations in aortic disease research at all levels, and we're delighted that the AHA has acknowledged our expertise with this grant. (
  • The first, led by Daugherty, will investigate how sex hormones, including testosterone and estrogen, impact development of thoracic aortic disease in mouse models. (
  • Lisa Cassis, professor of pharmacology and nutritional sciences and vice president for research, will lead a team to explore how sex chromosomes affect the development and progression of aortic diseases in both thoracic and abdominal aortas using unique mouse models in which sex chromosomes are manipulated. (
  • Unlike other vascular graft and endograft infections, especially of aortic and aortoenteric fistulas, vascular Q fever is usually caused by a single microorganism. (
  • At the UPMC Heart and Vascular Institute , our vascular surgeons are experts in treating diabetic arterial disease and its complications. (
  • In a retrospective study (2004-2009) evaluating data from 12,379 patients (41% women) in 16 centers participating in the Blue Cross Blue Shield of Michigan Cardiovascular Consortium PVI registry who underwent these procedures, female sex was associated with a higher rate of vascular complications, transfusions, and embolism, but no differences wer eseen for inpatient mortality, myocardial infarction (MI), or stroke or transient ischemic attack. (
  • In another retrospective study that evaluated data over 6 years from 23,870 index transfemoral vascular access procedures from cross-matching the Eastern Danish Heart Registry with the Danish Vascular Registry, Dencker et al noted a low risk of major vascular complications (0.54%) with femoral access following coronary angiography and percutaneous coronary intervention (PCI). (
  • Major femoral vascular access complications after coronary diagnostic and interventional procedures: A Danish register study. (
  • Your vascular system is your body's network of blood vessels. (
  • One key measure is achieving optimal vascular care for patients with vascular disease, a form of cardiovascular disease that affects the blood vessels. (
  • To provide themselves with a safe habitat, the bacteria bring about the increase of the number of "vascular endothelial" cells (cells that line the interior of blood vessels), which hide themselves from the host immune system and stimulate the creation of new blood vessels, through a process called "angiogenesis. (
  • [ 5 ] Studies have suggested that even asymptomatic peripheral arterial disease (PAD) is associated with increased CAD mortality. (
  • These factors can also worsen diabetic arterial disease that already exists. (
  • Why choose UPMC for diabetic arterial disease care? (
  • Vascular surgeons at the UPMC Heart and Vascular Institute treat more than 1,000 people with diabetic arterial disease each year. (
  • Using self-learning software, they were able to identify vascular changes in patients with peripheral arterial disease (PAD), often at an early stage. (
  • It is the main cause of heart attacks and strokes, the most frequent causes of death in western industrialized nations, as well as peripheral arterial disease (PAD). (
  • additionally, cavernous malformations and arterial aneurysms are vascular lesions that can also occur in the spine. (
  • Female sex appears to have an effect on outcomes after lower-extremity interventions for peripheral arterial disease (PAD). (
  • Current therapies and investigational drugs for peripheral arterial disease. (
  • OBJECTIVES: To evaluate peripheral arterial occlusive disease in HIV-infected patients regarding clinical presentation and outcome of surgical intervention. (
  • CONCLUSION: Patients presenting with HIV-associated peripheral arterial disease should be carefully selected for intervention, taking into consideration nutritional and immune status, stage of the vascular disease and selecting the appropriate procedure. (
  • In this study, we examined the relationship between arterial stiffness and retinal vascular caliber. (
  • Background and objectives Both increased arterial stiffness and vascular endothelial dysfunction are evident in patients with autosomal dominant polycystic kidney disease, even early in the course of the disease when kidney function in preserved. (
  • Design, setting, participants, & measurements We assessed carotid-femoral pulse-wave velocity (arterial stiffness) and brachial artery flow-mediated dilation (vascular endothelial function) in participants with early-stage autosomal dominant polycystic kidney disease (eGFR≥60 ml/min per 1.73 m 2 ) and a history of controlled hypertension and in healthy controls. (
  • 100), we also conducted PCR on an arterial biopsy or vascular graft sample. (
  • Therapeutic recommendations include single-agent antiplatelet agents for prevention of cardiovascular events in patients wth asymptomatic and symptomatic peripheral arterial disease (PAD). (
  • Minnesota's Heart Disease and Stroke Prevention Unit used Geographic Information Systems (GIS) to map the locations of clinics reporting on optimal vascular care, their 2010 performance on that measure, and county-level death rates for heart disease. (
  • In addition, the risk of a fatal heart attack or stroke is significantly increased - even in the early stages of the disease. (
  • Our aim was to test the benefits of pravastatin treatment in an elderly cohort of men and women with, or at high risk of developing, cardiovascular disease and stroke. (
  • A new generation of scientists tasked with tackling some of society's biggest killers, including vascular disease, heart attack and stroke will be trained at the University of Aberdeen following the award of a 3M Euro EU grant. (
  • Patients with a disease known as retinal vein occlusion (RVO) have a significantly higher incidence of stroke when compared with persons who do not have RVO, according to a report in the March issue of Archives of Ophthalmology, one of the JAMA/Archives journals. (
  • Heart, stroke and vascular disease-Australian facts, What is stroke? (
  • As a result of the substantial impact of stroke on the Australian population, a National Strategic Action Plan for Heart Disease and Stroke has been developed. (
  • Transgender females have a higher risk of ischemic stroke and cardiovascular disease. (
  • SCLS was also detected in 33 patients with idiopathic pulmonary fibrosis (IPF) and nine of 23 with collagen vascular diseases (CVD). (
  • Her academic and clinical interests include medical education, interstitial lung disease, and sarcoidosis. (
  • Clinically, his main interests are the care of patients with pulmonary hypertension and autoimmune-related lung disease. (
  • The Institute of Medicine report on a nationwide framework for surveillance of cardiovascular and chronic lung diseases observed that, as electronic health records become more ubiquitous and health information exchanges become operational, they could become powerful tools for improving health and relieving the burden of chronic diseases (7). (
  • Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the Chronic Renal Insufficiency Cohort - Am J Clin Nutr 2021 Nov 12 - 'Vascular calcification contributes to cardiovascular disease (CVD) and mortality in individuals with chronic kidney disease (CKD). (
  • In addition, the rising clinical burden of valvar calcification in the aging population has highlighted the importance of understanding the processes of calcification within vascular tissues. (
  • 5 It has therefore been suggested that the high ischaemic heart disease mortality rates in patients with renal failure may be partly attributable to increased vascular calcification. (
  • However, the effect of vitamin K on vascular calcification is unknown. (
  • Statins, vascular calcification, and vitamin K-dependent proteins: Is there a relation? (
  • Daily aspirin commonly is used for prevention of cardiac disease (CAD), but PVD often coexists, to some degree, in patients with CAD. (
  • Centers for Disease Control and Prevention. (
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (
  • The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (
  • Offering pulmonary vascular disease patients the latest in diagnostics, prevention, and treatment is at the forefront of the Vera Moulton Wall Center's mission. (
  • Participating in National Vascular Disease Awareness Month can be as simple as getting involved in a fundraiser or local community event, or using the time to educate yourself on the prevention steps available. (
  • When it comes to vascular disease and prevention, it's important to know what symptoms to look for and the treatment options available at FMC. (
  • I'm Commander Ibad Khan and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (
  • Gastroenteritis Branch in the Division of Viral Diseases at the Centers for Disease Control and Prevention. (
  • The following presentation contains content made by external presenters and not by the Centers for Disease Control and Prevention or the Department of Health and Human Services. (
  • Announcer] This program is presented by the Centers for Disease Control and Prevention. (
  • We developed a decision support tool that can guide the development of heart disease prevention programs to focus on the interventions that have the most potential to benefit populations. (
  • We developed a spreadsheet-based decision support tool that helps the user determine which heart disease prevention and treatment interventions would be expected to have the biggest effect on mortality in a population (1). (
  • She cares for patients in both the outpatient and inpatient setting, and provides compassionate, thoughtful, communicative and individualized care to patients and their families as they navigate through the disease course. (
  • Patients with acute emboli causing limb ischemia may have new or chronic atrial fibrillation, valvular disease, or recent myocardial infarction (MI), whereas a history of claudication, rest pain, or ulceration suggests thrombosis of existing PVD. (
  • Clinic performance is determined by the proportion of patients with vascular disease who meet 4 goals: appropriate aspirin therapy, blood pressure control, cholesterol control, and smoking cessation. (
  • Questionnaire-Based Study of 81 Patients in Poland to Evaluate the Course of Inflammatory Bowel Disease and. (
  • Objectives To analyse the differences in the clinical features and characteristics of 123 I-labelled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ( 123 I-FP-CIT) single photon emission CT (SPECT) imaging among patients with vascular parkinsonism (VP) and Parkinson's disease (PD). (
  • Results Patients with VP had a higher age at symptom onset and lower disease duration than patients with PD. (
  • PATIENTS AND METHODS: Routine voluntary testing for HIV / AIDS was performed in all patients presenting to our vascular unit. (
  • RESULTS: We identified 154 HIV+ patients, of whom 91 (59%) presented with occlusive disease. (
  • More than 90% of the patients presented with advanced stage vascular disease (Fontaine III/IV), which explains the high rate (31.9%) of primary amputation. (
  • Cerebral blood flow study in patients with moyamoya disease evaluated by IMP SPECT. (
  • Temporary neurologic deterioration due to cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in patients with adult-onset moyamoya disease. (
  • We report 5 cases of vascular Q fever complicated by polymicrobial superinfection in patients who had no risk factors for acute Q fever. (
  • Of 425 patients with vascular infections during January 2004-June 2020, 16 had Q fever, including 7 since 2019, when BUH and Bayonne Hospital began conducting systematic Q fever serologic assays for all patients with vascular infections. (
  • In total, 5 patients (1 with aortitis and 4 with vascular graft and endograft infections) had vascular Q fever complicated by polymicrobial superinfection in the abdominal aorta ( Table 1 ). (
  • Four patients tested positive by PCR on vascular or graft samples, whereas patient 5 tested positive by PCR on a vertebral biopsy ( Table 1 ). (
  • 44 patients had vascular infections, 12 had endocarditis, and 1 had both conditions. (
  • Surgical resection remains one of the only curative therapeutic options for HCC, although it is indicated in select patients with localized disease. (
  • Members are medical specialists involved in the care and treatment of patients suffering from vascular disease. (
  • Dr. Heyka's specialty interests include chronic and acute renal failure, dialysis, hypertension, renal bone disease, cardiovascular disease in kidney patients, and vascular access for dialysis. (
  • Two groups of patients were studied: patients with established CV disease (CVD) and healthy patients at moderate risk for CVD (a control group). (
  • We also compared the records of patients who had a gap in enrollment of more than 31 days with those who did not, and compared patients who had no visits, only 1 visit, or 2 or more visits more than 31 days apart for heart disease. (
  • and Cohen's , 0.94, 95% CI, 0.89-0.98, respectively) when patients with only 1 visit were considered to have heart disease. (
  • In contrast, optimizing care for patients in this same age group who are hospitalized for coronary heart disease or heart failure would prevent or postpone approximately 8% of all deaths. (
  • After extracting data from the electronic health records of a single medical group, we also used the decision support tool to identify opportunities to prevent or postpone deaths among patients being treated for heart disease (8). (
  • Atheroembolic renal disease. (
  • Atheroembolic renal disease is becoming a common cause of renal insufficiency (poor kidney function) in the elderly. (
  • Renal vascular disease is often associated with hypertension (high blood pressure). (
  • Decreased blood flow to the kidney(s) as a result of renal vascular disease may cause an excessive amount of renin to be produced. (
  • Autosomal dominant polycystic kidney disease can lead to end-stage renal disease. (
  • Other neurodegenerative diseases, such as Parkinson's disease with dementia, are included when AD is also being studied and when common pathways are described. (
  • Frustrations and Victories in 5 New Neurology Studies Dr Christoph Diener on disappointing results for monoclonal antibodies in Parkinson's disease, and more favorable findings for diabetic pain and rheumatic heart disease. (
  • Symptoms of cerebrovascular disease will vary but commonly include headache, weakness or paralysis of one side, confusion, slurred speech, and loss of vision. (
  • Acetazolamide as a vasodilatory stimulus in cerebrovascular diseases and in conditions affecting the cerebral vasculature. (
  • One of the more common vascular diseases involves varicose veins, and blood ultimately pools within the area of the leg. (
  • There is no singular reason an individual develops varicose veins, but many correlate the vascular issue to genetic makeup. (
  • Individuals who are concerned about developing the vascular disease, including varicose veins, can and should focus on lifestyle changes first. (
  • Vascular disease can also affect the veins in the form of blood clots, venous stasis disease or varicose veins. (
  • Those with peripheral vascular disease affecting the veins may experience swelling of the legs or ankles, especially at night, or pain in the affected leg or arm. (
  • Maintains tone and elasticity of your veins-the key to sustained vascular health. (
  • however, a variable but measurable amount of AD pathologic changes exist in most cognitively intact elderly individuals who undergo autopsy, indicating that AD is a chronic disease with latent and prodromal stages and suggesting that individuals may have varying abilities to compensate, either biologically or functionally, for the presence of AD. (
  • The Chronic Disease GIS Exchange is an online community forum for sharing maps, training materials and GIS resources. (
  • Vascular endothelial dysfunction increases cardiovascular (CV) risk and contributes to the progression of chronic kidney disease (CKD). (
  • Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic disease, rooted in multi-system dysfunctions characterized by unexplained debilitating fatigue. (
  • In 2006, a survey conducted in Iraq on chronic noncommunicable disease risk factors revealed that the prevalence of hypertension was 40.4% (9). (
  • A meta-analysis conducted by the Chronic Kidney Disease Prognosis Consortium published on May 18, 2010 in The Lancet concluded that elevations in urinary albumin and albumin to creatinine ratio, which indicate kidney damage, as well as a reduction in the estimated glomerular filtration rate (eGFR) of the kidneys predict an increased risk of death from all causes over 2.1 to 11.6 years of follow-up. (
  • This study provides quantitative data for use of both kidney measures for risk assessment and definition and staging of chronic kidney disease. (
  • The risk of mortality was elevated by nearly 50 percent at 30 mg/gram albumin to creatinine ratio, which is the threshold for defining chronic kidney disease. (
  • You may be surprised to learn that until 2002, no standard definition for chronic kidney disease (CKD) existed within the medical community. (
  • To identify the magnitude of the opportunities among the population with chronic heart disease, disease prevalence must be known. (
  • It is not known whether the ACE present in vascular endothelium is inhibited longer than the ACE in circulating blood. (
  • The symptoms of spinal vascular malformations can be broken into two categories: a) progressive spinal cord dysfunction and b) sudden problems due to malformation bleeding. (
  • I he hypothesis tested is that cerebral and systemic vascular ultrastructural impairments precede the onset of cognitive dysfunction in APP/PS1 mice representing a therapeutic target to slow the development of disease progression in this AD model. (
  • Vascular dysfunction in autosomal dominant polycystic kidney disease is thought to be related to vascular oxidative stress and inflammation, but direct evidence is lacking. (
  • Hyperglycemia causes neutrophil dysfunction by increasing intracellular calcium levels and interfering with actin and, thus, diapedesis and phagocytosis.Associated vaginal candidiasis and vascular disease also play a role in recurrent infections.SGLT2 inhibitors markedly increase glucose excretion by the kidney which may lead to a UTI. (
  • Retinal vein occlusion (RVO) is a retinal vascular disease in which a retinal vein is compressed by an adjacent retinal artery, resulting in blood flow turbulence, thrombus formation, and retinal ischemia," the authors write as background information in the article. (
  • [ 2 ] All dementia share common molecular mechanisms responsible for disease etiology and progression, such as hypoxia and oxidative stress, neuroinflammation, mitochondrial bioenergetics, neurodegeneration, and blood-brain barrier permeability. (
  • [ 21 ] Although lacking an immediate effect on any vascular process, statins show promise in slowing the progression of atherosclerotic disease systemically. (
  • While elevated intraocular pressure (IOP) is a clear risk factor, vascular insufficiency and abnormal autoregulation of the optic nerve circulation have been hypothesised to play a significant role in the development and progression of glaucoma. (
  • are currently researching LOXL2 (lysine-oxidase-like-2), which might be intimately involved in the development or progression of vascular stiffness. (
  • The study of vascular disease is a vitally important enterprise, as its prevalence is expected to increase dramatically as our population ages," said Alan Daugherty, chair of the department of physiology, director of the Saha Cardiovascular Research Center in the College of Medicine and UK associate vice president for research. (
  • The prevalence rate of the subpleural curvilinear shadow (SCLS) was examined in several interstitial pulmonary diseases and in asbestos (1332214) workers with normal chest roentgenograms in an effort to analyze the significance of the SCLS in pulmonary asbestos is. (
  • Suggested citation for this article: Kottke TE, Baechler CJ, Parker ED. Accuracy of Heart Disease Prevalence Estimated from Claims Data Compared With an Electronic Health Record. (
  • To use it, however, users need to know the prevalence of heart disease in the population that they wish to help. (
  • We sought to determine the accuracy with which the prevalence of heart disease can be estimated from health care claims data. (
  • In this population, prevalence of heart disease can be estimated from claims data with acceptable accuracy. (
  • This tool can assist in nationwide efforts to control the prevalence of heart disease -- for example, The Million Hearts initiative (2), Healthy People 2020 (3), and the American Heart Association 2020 goals for disease control (4) and disease surveillance (5) -- by identifying the interventions that are expected to have the greatest impact on deaths among populations. (
  • Overnutrition exacerbates pro-inflammatory signalling in vascular and adipose tissues, with several mechanisms proposed to mediate this. (
  • In this article, we review the molecular and cellular mechanisms by which nutrients are proposed to regulate pro-inflammatory signalling in adipose and vascular tissues. (
  • 6,400 or molecular detection in blood or infected tissues, as well as clinical signs of a vascular infection or evidence from computed tomography or nuclear imaging scans ( 6 ). (
  • The Pulmonary Vascular Disease Learning Pathway at ACC.23/WCC features a collection of pulmonary hypertension (PH) sessions for a diverse population of providers, including those just beginning to learn about PH all the way to PH experts. (
  • Regarding its contribution to the growing global pandemic of CVD, recently confirmed by the update of the Global Burden of Disease Study (2000), hypertension is estimated to be responsible for around 50% of CVDs worldwide (4). (
  • About three-quarters of people with hypertension are from low- and middle-income countries, as access to healthcare, as well as awareness of the disease, are inadequate. (
  • Work is being undertaken to calculate heart disease mortality rates for geographic areas smaller than counties in order to assess the impact of poor control of vascular disease risk factors on heart disease mortality in Minnesota communities. (
  • In particular, the Minnesota Department of Health is interested in examining the patterns of vascular disease risk factor management and heart disease mortality among urban, suburban, small towns and rural communities throughout the state. (
  • Mortality from coronary disease fell by 24% (p=0.043) in the pravastatin group. (
  • Major lipids, apolipoproteins, and risk of vascular disease. (
  • CONTEXT: Associations of major lipids and apolipoproteins with the risk of vascular disease have not been reliably quantified. (
  • Coronary heart disease death and non-fatal myocardial infarction risk was also reduced (0.81, 0.69-0.94, p=0.006). (
  • During 2.79 million person-years of follow-up, there were 8857 nonfatal myocardial infarctions, 3928 coronary heart disease [CHD] deaths, 2534 ischemic strokes, 513 hemorrhagic strokes, and 2536 unclassified strokes. (
  • to advance excellence and innovation in vascular and venous disease, and related cardiovascular conditions. (
  • We expect this knowledge will help us better understand heart disease and will be instrumental for stem-cell-based disease modeling and interventions for of heart repair. (
  • Baltic countries: even with big opportunities to increase the intensity of care for acute events, interventions that prevent and control heart disease risk factors would more effectively reduce deaths (6). (
  • These may seem like small strategies to help prevent vascular disease, but they can work wonders on creating a healthier body that is less likely to develop severe medical conditions over time. (
  • The Miller Family Heart, Vascular & Thoracic Institute has created a series of online presentations to provide you with information about heart, vascular, and thoracic conditions and treatments. (
  • Explore our free online video presentations for information about heart, vascular and thoracic conditions and treatments. (
  • The map also illustrates which counties experience the highest annual rates of heart disease deaths. (
  • Mapping these data together reveals that most (63%) clinics performing below the state average, excluding the Twin Cities metropolitan area, are in counties with the highest heart disease death rates. (
  • Research has shown that achieving these goals helps reduce deaths from heart disease. (
  • The map shows that outside the Twin Cities metropolitan area, most (63%) clinics performing below the state average are located in counties with the highest heart disease death rates. (
  • More important still, focus on recognizing the risk factors and identify how you can make lifestyle changes to help prevent heart and vascular disease altogether. (
  • UK and Baylor were one of four teams nationwide to receive the honor, which coincides with the establishment of the American Heart Association's Vascular Research Disease Network. (
  • Our Association is excited about this newly funded research network, targeting vascular diseases," said Joey Maggard, executive director of the Lexington Division of the American Heart Association. (
  • Women generally have a low risk for heart disease until menopause, when their estrogen levels decline. (
  • Given the Chief's underlying coronary heart disease, NIOSH investigators concluded that the physical stress of performing physical fitness training may have triggered a cardiac arrhythmia and a possible heart attack resulting in his sudden cardiac death. (
  • We believe this knowledge will contribute to our understanding of congenital and adult heart disease and be instrumental for stem cell-based heart regeneration. (
  • Dr. Chulan Kwon is an assistant professor of medicine at the Johns Hopkins University Heart and Vascular Institute. (
  • Heart & vascular health support group for survivors of strokes. (
  • Heart & vascular health support group for people with heart and vascular disease. (
  • This active group of researchers and clinicians in London hold expertise in diseases associated with aging of cells of the brain, vasculature or heart. (
  • Discuss the Selye and Lazarus models of stress and coping and to describe the roles psychological factors play in physical illnesses such as peptic ulcers, coronary heart disease and death from cancer. (
  • Heart and Vascular clinical trials currently include PFO and Embolic CVA, peripheral vascular disease, electrophysiology and arrhythmia, cardiology imaging and advanced heart failure. (
  • Systematic review of prospective cohort studies of psychosocial factors in the etiology and prognosis of coronary heart disease. (
  • However, when clinical samples (e.g., blood, vascular graft tissue) test positive for bacterial infection, no recommendation exists for screening for additional microorganisms. (
  • We aimed to describe vascular infection or endocarditis caused by Campylobacter spp. (
  • We present the case of a middle-aged woman with vascular disease who was incorrectly diagnosed with refractory C. difficile infection due to the presence of pseudomembranes. (
  • Pseudomembranous colitis is commonly associated with Clostridium difficile infection (CDI) but can be a consequence of other disease processes. (
  • Moreover, it is reported that, in 2001, the number of deaths resulting from hypertensive cardiac diseases in the Middle East and North Africa was 115 per 100 000, and the number of disability-adjusted life years resulting from hypertensive cardiac diseases was 1389 per 100 000 (8). (
  • Cardiac and vascular disord. (
  • Here we use the microvascular corrosion casting technique with scanning electron microscopy (SEM) to recreate and examine the cerebral and systemic vascular ultrastructure of the APPswe/PS1dE9 (APP/PS1) murine model of AD. (
  • Our aims are to determine whether cerebral and systemic vascular ultrastructural impairments coincide with the neuropathology of 9-month old APP/PS1 mice and that liraglutide (Victoza®) treatment can restore vascular ultrastructure (chapter 3). (
  • The Leptomeningeal "Ivy Sign" on Fluid-Attenuated Inversion Recovery MR Imaging in Moyamoya Disease: A Sign of Decreased Cerebral Vascular Reserve? (
  • The relationship between cerebral infarction and angiographic characteristics in childhood moyamoya disease. (
  • Quantification of the regional cerebral blood flow and vascular reserve in moyamoya disease using split-dose iodoamphetamine I 123 single-photon emission computed tomography. (
  • Cerebral vascular disease / edited by M. J. G. Harrison and Mark L. Dyken. (
  • The potential impact of the proposed study stems from the new information it contributes on age-related vascular changes as modifiable risk factors for cerebral microvascular damage, cognitive function, and dementia. (
  • If you have questions about the signs or symptoms of vascular disease, treatments, or ways to prevent vascular disease, schedule an appointment with one of the specialists at Banner Health. (
  • Take part in the Pulmonary Vascular Disease Learning Pathway for these exciting, informative sessions and more! (
  • It is becoming increasingly apparent that personalized therapies are key to successful management of pulmonary vascular disease, but this cannot be achieved without an integrated approach to investigating the condition and an individual's response to therapy. (
  • Computational models provide a means to link investigations across the spectrum from cellular mechanisms to potential improvements in pulmonary vascular function over the course of a therapeutic strategy. (
  • Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations. (
  • These results suggest a model in which critical interactions between inflammatory and thrombosis pathways lead to SARS-CoV-2 -induced vascular disease . (
  • Certain medications, chemical injury, collagenous colitis, inflammatory bowel disease, ischemia, and other infectious pathogens can reportedly cause mucosal injury and subsequent pseudomembrane formation. (
  • Peripheral Artery Disease (PAD) in the Diabetic Population, featuring Drs. Kirksey, Khatri and Botek. (
  • In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease. (
  • The causes of vascular diseases depend on the specific disease. (
  • Our comprehensive, team-based approach includes vascular, orthopaedic, plastic, and general surgeons - as well as podiatry and internal medicine professionals - all working together to provide an effective treatment plan that is right for you. (
  • Results In total, 61 participants with autosomal dominant polycystic kidney disease (34±9 years old [mean±SD]) and 19 healthy controls (30±5 years old) were studied. (
  • Brachial artery flow-mediated dilation was 8.2%±5.8% in participants with autosomal dominant polycystic kidney disease and 10.8%±4.7% in controls ( P =0.08). (
  • Conclusions These results provide support for the hypothesis that vascular oxidative stress and inflammation develop with autosomal dominant polycystic kidney disease. (
  • Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening genetic disease, affecting approximately 1:500-1:1000 live births ( 1 ). (
  • Research in the Josef Coresh Lab focuses on cardiovascular epidemiology, kidney disease and gen ... etic epidemiology. (
  • The Consortium, which was established in 2009 by KDIGO (Kidney Disease: Improving Global Outcomes), selected 21 studies including a total of 1,234,182 participants from 14 countries for their analysis. (
  • The primary factor for developing peripheral vascular disease (PVD) is atherosclerosis. (
  • To date the therapy of atherosclerosis often focuses on alleviating symptoms rather than treating the underlying causes of the disease -which are not fully understood. (
  • Methods: A cross-sectional, population-based study of 5,731 participants (aged 45-84 years) who were free of clinical cardiovascular disease (the Multi-Ethnic Study of Atherosclerosis). (
  • Learn more about maintaining your vascular health at home, warning signs that should not be ignored, and how to get help for any health concerns. (
  • These videos highlight questions and answers about vascular disease and treatments by our health care professionals. (
  • The Minnesota Department of Health plans to focus improvement efforts and resources for optimal vascular care, including control of high blood pressure, on those clinics performing below the state average. (
  • No matter which type of vascular disease you may be dealing with, Banner Health is here to support you in your journey to healthy living. (
  • Fukui M. Annual Report 1993: The Research Committee on Spontaneous Occlusion of the Circle of Willis (Moyamoya Disease) of the Ministry of Health and Welfare. (
  • Offering in-depth coverage of all areas of health and disease, Human Diseases and Conditions, 3rd ed. offers current and accurate information on approximately 450 diseases and conditions. (
  • Our mission is to improve vascular health for the public benefit. (
  • We're pleased to have with us Ms. Amanda Ingram, who's an Epidemiologist Supervisor working in the Infectious Diseases and Outbreaks Division at the Alabama Department of Public Health. (
  • In addition, we examine the potential therapeutic opportunities that these mechanisms provide for suppression of inappropriate inflammation in obesity and vascular disease. (
  • One goal of our research is to identify the factors that cause vascular stiffness. (
  • Research in the Jochen Steppan Lab primarily focused on vascular stiffness related to aging. (
  • The Vascular and Integrative Physiology (VIP) Lab studies vascular physiology and cardiovascular disease pathophysiology. (
  • Symptoms of spinal vascular malformations vary depending on the type of vascular problem and the level(s) of the spinal cord involved. (
  • The Vascular Laboratory at Robert Wood Johnson University Hospital Somerset offers a full range of non-invasive, painless tests to promote the early detection and management of vascular disease. (
  • It also causes problems with the surgical management of vascular shunts. (