Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
A thiol-containing amino acid formed by a demethylation of METHIONINE.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
The nonstriated involuntary muscle tissue of blood vessels.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 µmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
The main trunk of the systemic arteries.
A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
The inferior part of the lower extremity between the KNEE and the ANKLE.
An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
The main artery of the thigh, a continuation of the external iliac artery.
Operative procedures for the treatment of vascular disorders.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.
The vessels carrying blood away from the heart.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
Formation and development of a thrombus or blood clot in the blood vessel.
Elements of limited time intervals, contributing to particular results or situations.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Death and putrefaction of tissue usually due to a loss of blood supply.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Radiography of blood vessels after injection of a contrast medium.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.
Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Enzymes catalyzing the dehydrogenation of secondary amines, introducing a C=N double bond as the primary reaction. In some cases this is later hydrolyzed.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
Pathological processes involving any part of the AORTA.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Inflammation of the inner endothelial lining (TUNICA INTIMA) of an artery.
The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.
The region of the lower limb between the FOOT and the LEG.
An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Pathologic deposition of calcium salts in tissues.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This enzyme was formerly classified as EC
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The flow of BLOOD through or around an organ or region of the body.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
Prosthetic replacements for arms, legs, and parts thereof.
Nutrient blood vessels which supply the walls of large arteries or veins.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.
Conditions with excess LIPIDS in the blood.
The blood vessels which supply and drain the RETINA.
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
Any one of five terminal digits of the vertebrate FOOT.
Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).
Hypertrophy and dilation of the RIGHT VENTRICLE of the heart that is caused by PULMONARY HYPERTENSION. This condition is often associated with pulmonary parenchymal or vascular diseases, such as CHRONIC OBSTRUCTIVE PULMONARY DISEASE and PULMONARY EMBOLISM.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Autosomal recessive inborn error of methionine metabolism usually caused by a deficiency of CYSTATHIONINE BETA-SYNTHASE and associated with elevations of homocysteine in plasma and urine. Clinical features include a tall slender habitus, SCOLIOSIS, arachnodactyly, MUSCLE WEAKNESS, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence of MENTAL RETARDATION, and a tendency to develop fibrosis of arteries, frequently complicated by CEREBROVASCULAR ACCIDENTS and MYOCARDIAL INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, p979)
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Inhaling and exhaling the smoke of burning TOBACCO.
A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.
Drugs used to cause dilation of the blood vessels.
The part of the foot between the tarsa and the TOES.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
The part of a limb or tail following amputation that is proximal to the amputated section.
Pathological conditions involving the HEART including its structural and functional abnormalities.
An FAD-dependent oxidoreductase found primarily in BACTERIA. It is specific for the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This enzyme was formerly listed as EC and
Blockage of the RETINAL VEIN. Those at high risk for this condition include patients with HYPERTENSION; DIABETES MELLITUS; ATHEROSCLEROSIS; and other CARDIOVASCULAR DISEASES.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
An idiopathic, segmental, nonatheromatous disease of the musculature of arterial walls, leading to STENOSIS of small and medium-sized arteries. There is true proliferation of SMOOTH MUSCLE CELLS and fibrous tissue. Fibromuscular dysplasia lesions are smooth stenosis and occur most often in the renal and carotid arteries. They may also occur in other peripheral arteries of the extremity.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The vessels carrying blood away from the capillary beds.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A sulfur-containing essential L-amino acid that is important in many body functions.
Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Inflammation of the wall of the AORTA.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.
The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Central retinal artery and its branches. It arises from the ophthalmic artery, pierces the optic nerve and runs through its center, enters the eye through the porus opticus and branches to supply the retina.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.
Inability to achieve and maintain an erection (ERECTILE DYSFUNCTION) due to defects in the arterial blood flow to the PENIS, defect in venous occlusive function allowing blood drainage (leakage) from the erectile tissue (corpus cavernosum penis), or both.
The condition of an anatomical structure's being constricted beyond normal dimensions.
A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Abnormally high BLOOD GLUCOSE level.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
A natural product that has been considered as a growth factor for some insects.
Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The veins and arteries of the HEART.
A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.
Subspecialty of radiology that combines organ system radiography, catheter techniques and sectional imaging.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Methods and procedures for the diagnosis of diseases or dysfunction of the cardiovascular system or its organs or demonstration of their physiological processes.
Techniques for measuring blood pressure.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.
An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.

Systemic infection with Alaria americana (Trematoda). (1/2352)

Alaria americana is a trematode, the adult of which is found in mammalian carnivores. The first case of disseminated human infection by the mesocercarial stage of this worm occurred in a 24-year-old man. The infection possibly was acquired by the eating of inadequately cooked frogs, which are intermediate hosts of the worm. The diagnosis was made during life by lung biopsy and confirmed at autopsy. The mesocercariae were present in the stomach wall, lymph nodes, liver, myocardium, pancreas and surrounding adipose tissue, spleen, kidney, lungs, brain and spinal cord. There was no host reaction to the parasites. Granulomas were present in the stomach wall, lymph nodes and liver, but the worms were not identified in them. Hypersensitivity vasculitis and a bleeding diathesis due to disseminated intravascular coagulation and a circulating anticoagulant caused his death 8 days after the onset of his illness.  (+info)

Study of an epidemic of venoocclusive disease in India. (2/2352)

Twenty-five cases of rapidly developing ascites occurring in an epidemic form were observed in a tribal district in Central India during August 1972-May 1973. Eleven of the patients died. Six patients were brought to hospital and studied for periods of two to 17 months. Necropsy was performed on one patient who died. The clinical features suggested an outflow tract obstruction such as a Budd-Chiari-like syndrome or venoocclusive disease. Radiographic and haemodynamic studies demonstrated a combination of post and perisinusoidal blocks. Liver dysfunction was indicated by the presence of a marked bromsulphthalein retention and mild to moderate hypoalbuminaemia. Histological examination of the liver biopsies showed changes that ranged from centrizonal haemorrhagic necrosis to an extensive centrilobular fibrosis associated with central vein occlusion. The disease was apparently caused by a food toxin, and the possible nature of this is discussed.  (+info)

Prevalence of angiographic atherosclerotic renal artery disease and its relationship to the anatomical extent of peripheral vascular atherosclerosis. (3/2352)

BACKGROUND: Recognition of the possible presence of atherosclerotic renal artery disease (ARAD) is important because of its progressive nature, and because of the potential for precipitating an acute deterioration in renal function by administration of angiotensin-converting enzyme inhibitors. The aim of this study was to identify the prevalence of ARAD in patients undergoing peripheral angiography and its relationship to the extent of their peripheral vascular disease (PVD). METHODS: The reports of the 218 patients who underwent peripheral angiography to investigate PVD in one centre in a calendar year, and in whom it was possible to image the renal arteries, were analysed retrospectively. The presence of atherosclerotic disease in the renal, aortic, iliac, femoral and distal areas was recorded for each patient. RESULTS: The prevalence of ARAD was 79/218 (36.2%). The greater the number of atherosclerotic areas of the arterial tree, the higher the prevalence of ARAD. Patients with aortic disease and bilateral iliac, femoral and distal vessel disease had the highest incidence of ARAD 19/38 (50%). The incidence of ARAD in those with femoral artery atherosclerosis was significantly higher than in those without femoral artery atherosclerosis (42.1% compared with 9.7%, P=0.001 chi2). There was no significant difference in those groups with or without iliac and distal disease. None of the 11 patients with normal femoral and iliac arteries had ARAD. CONCLUSIONS: Renal artery atherosclerosis is a common occurrence in patients with PVD. If extensive PVD is recognized during aortography, a high flush should be considered to examine the renal arteries, if they are not included in the main study.  (+info)

Relief of obstructive pelvic venous symptoms with endoluminal stenting. (4/2352)

PURPOSE: To select patients for percutaneous transluminal stenting of chronic postthrombotic pelvic venous obstructions (CPPVO), we evaluated the clinical symptoms in a cohort of candidates and in a series of successfully treated patients. METHODS: The symptoms of 42 patients (39 women) with CPPVO (38 left iliac; average history, 18 years) were recorded, and the venous anatomy was studied by means of duplex scanning, subtraction venography, and computed tomography or magnetic resonance imaging. Successfully stented patients were controlled by means of duplex scanning and assessment of symptoms. RESULTS: The typical symptoms of CPPVO were reported spontaneously by 24% of patients and uncovered by means of a targeted interview in an additional 47%. Of 42 patients, 15 had venous claudication, four had neurogenic claudication (caused by dilated veins in the spinal canal that arise from the collateral circulation), and 11 had both symptoms. Twelve patients had no specific symptoms. Placement of a stent was found to be technically feasible in 25 patients (60%), was attempted in 14 patients, and was primarily successful in 12 patients. One stent occluded within the first week. All other stents were fully patent after a mean of 15 months (range, 1 to 43 months). Satisfaction was high in the patients who had the typical symptoms, but low in those who lacked them. CONCLUSION: Venous claudication and neurogenic claudication caused by venous collaterals in the spinal canal are typical clinical features of CPPVO. We recommend searching for these symptoms, because recanalization by means of stenting is often feasible and rewarding.  (+info)

Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. (5/2352)

Receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules and engages diverse ligands relevant to distinct pathological processes. One class of RAGE ligands includes glycoxidation products, termed advanced glycation end products, which occur in diabetes, at sites of oxidant stress in tissues, and in renal failure and amyloidoses. RAGE also functions as a signal transduction receptor for amyloid beta peptide, known to accumulate in Alzheimer disease in both affected brain parenchyma and cerebral vasculature. Interaction of RAGE with these ligands enhances receptor expression and initiates a positive feedback loop whereby receptor occupancy triggers increased RAGE expression, thereby perpetuating another wave of cellular activation. Sustained expression of RAGE by critical target cells, including endothelium, smooth muscle cells, mononuclear phagocytes, and neurons, in proximity to these ligands, sets the stage for chronic cellular activation and tissue damage. In a model of accelerated atherosclerosis associated with diabetes in genetically manipulated mice, blockade of cell surface RAGE by infusion of a soluble, truncated form of the receptor completely suppressed enhanced formation of vascular lesions. Amelioration of atherosclerosis in these diabetic/atherosclerotic animals by soluble RAGE occurred in the absence of changes in plasma lipids or glycemia, emphasizing the contribution of a lipid- and glycemia-independent mechanism(s) to atherogenesis, which we postulate to be interaction of RAGE with its ligands. Future studies using mice in which RAGE expression has been genetically manipulated and with selective low molecular weight RAGE inhibitors will be required to definitively assign a critical role for RAGE activation in diabetic vasculopathy. However, sustained receptor expression in a microenvironment with a plethora of ligand makes possible prolonged receptor stimulation, suggesting that interaction of cellular RAGE with its ligands could be a factor contributing to a range of important chronic disorders.  (+info)

Chronic retinal vein occlusion in glaucoma. (6/2352)

Asymptomatic chronic retinal vein occlusion that occurs in chronic simple glaucoma is described. The condition is characterized by marked elevation of retinal vein pressure with collateral vessels and vein loops at the optic disc in cases of central vein occlusion, or retinal veno-venous anastomoses along a horizontal line temporal and nasal to the disc in hemisphere vein occlusion. No patient had visible arterial changes, capillary closure, fluorescein leakage, or haemorrhages. The vein occlusion was not limited to "end stage" glaucoma. The role of increased intraocular pressure and glaucomatous enlargement of the optic cup with retinal vein distortion in the pathogenesis of the condition was stressed. Follow-up of these patients revealed persistence of the retinal vein occlusion shown by elevated retinal vein pressures. This would reduce effective perfusion of the inner retina and optic disc and may affect the long-term visual prognosis.  (+info)

Perifoveal vascular leakage and macular oedema after intracapsular cataract extraction. (7/2352)

Perifoveal capillary leakage of fluorescein was demonstrated in 60 per cent of 50 eyes when angiography was performed two weeks after cataract extraction. Repeat angiography six weeks postoperatively in 17 eyes demonstrated persistence of already established leakage in 11 of 12 eyes and no new leakage in five eyes previously negative. Cystoid macular oedema with visual acuity of less than 20/40 six weeks postoperatively occurred in five eyes (10 per cent). Eyes of patients with vascular disease and those patients of 60 years or older were found to have altered vascular permeability significantly more frequently. Inflammation was no more severe or prevalent in those patients who demonstrated leakage and no inflammation was clinically apparent in 10 of 11 eyes demonstrating dye leakage six weeks postoperatively. We conclude that the constitutional factors of age and vascular disease are of prime importance in causing altered vascular permeability in the early postoperative period after cataract extraction; factors causing sustained leakage with reduction of visual acuity were not demonstrated.  (+info)

A prospective study of xenon arc photocoagulation for central retinal vein occlusion. (8/2352)

Twenty patients with central retinal vein occlusion were randomly divided into two groups in a prospective study to evaluate the effects of xenon are photocoagulation in central retinal vein occlusion. The patients in one group were treated with 360 degrees scatter xenon photocoagulation and the others received no treatment. The average follow-up was 18 months. There were no cases of rubeosis or neovascular glaucoma in the treated group. Two patients in the untreated group developed rubeosis with subsequent neovascular glaucoma. There was no significant difference in the visual prognosis or in fundus neovascularization between the groups.  (+info)

Throughout middle and old age, usual blood pressure is strongly and directly related to vascular (and overall) mortality, without any evidence of a threshold down to at least 115/75 mm Hg.
Researchers at Medical College of Georgia have found that circadian clocks that set the rhythmic motion of our bodies for wakeful days and sleepy nights can also set us up for
When it comes to diagnosing vascular disease and treating vascular disease, Hoag Heart & Vascular Institute is a nationally recognized leader.
If there is a proven diagnosis, or even if we just find a little thickening of the arteries in your neck then you need all of the treatments that work for vascular disease. They are the LIFESAVERS and lifestyle changes that you can review in more detail on the information sheet. But thats not all. You also need to be investigated for vascular disease elsewhere, particularly in the heart. Why the heart? Because no matter where else vascular disease is found in your body, your greatest risk of dying from this disease is heart attack or complications of heart attack. For this reason, we look for signs of your heart arteries being involved. This is usually done by having you undergo a stress test either exercising on a treadmill or bike, or if you cant exercise to a high enough level there are ways to use medications to simulate exercise thereby allowing us to find out if there are any blockages. ...
A number of diseases that can affect arteries and veins throughout the body but the most common vascular disease is atherosclerosis, or hardening of the arteries. This condition affects virtually every artery within the body. Peripheral Vascular Disease includes all the arteries and veins in the body except those within the heart and within the brain.
The vascular system is the network of blood vessels that circulate blood to and from the heart and lungs. Vascular diseases are very common, especially a
The vascular disease causes may be different depending on the specific condition. Some of these include smoking, high fat diet, diabetes, lack of physical exercise.
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles.
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It is important for individuals completing a long-distance hike to be aware of the potential deleterious changes associated with large volumes of exercise and consuming a high-calorie, low-quality diet, they conclude in the paper.
It is important for individuals completing a long-distance hike to be aware of the potential deleterious changes associated with large volumes of exercise and consuming a high-calorie, low-quality diet, they conclude in the paper.
Nonetheless, due to limited space we do ask that you invite no collagen vascular disease and pregnancy than 2 collaegn. With my 2nd youngster, I keep in mind getting that crampy feeling right after and it lasted for awhile. Now that a variety of hCG or human Chorionic Gonadotropin hormone is secreted within the physique extra meals aversions, sensitivity to odor, fatigue and constipation may be expected. As I discussed, these guys do not have these issues. Collahen involuntary leaking could occur when coughing, sneezing and collagen vascular disease and pregnancy laughing. As mentioned earlier, its not unusual for a woman to spot during her first 12 weeks of being pregnant. When crucial, I embrace further postpartum visits to insure that diseasd gets off to a terrific begin. Oxytocin itself may cause uterine contractions and thus Collagen vascular disease and pregnancy can cross-react with oxytocin receptors and trigger contractions. A prenatal multivitamin doesnt replace a healthy diet. Cite ...
Question - I have a past history of collagen vascular disease and leukopenia. Is swollen bulging eye and pain behind the ear a symptom of connective tissue disease and autoimmune thyroid ?. Ask a Doctor about Thyroid, Ask a Hematologist has published new research report on Global Peripheral Vascular Disease (PVD) Drug Industry 2012-2022 Market Research Report to its database.. The Global Peripheral Vascular Disease (PVD) Drug Market report has key insights on the global Peripheral Vascular Disease (PVD) Drug Market for the clients who wish to broaden their spectrum in the market and expand their reach. Individuals interested in the report for purely academic purposes also have a substantial amount of data presented to suit their requirements.. The Global Peripheral Vascular Disease (PVD) Drug Market is being actively pursued by a substantial amount of key players across the globe. The market is caught major traction, especially in China which is the reason for the key insights presented in this report for China, along with the globe.. Major Global Markets Thrive with China Holding the Largest Piece of the Pie. The Chinese market for Peripheral Vascular Disease (PVD) Drug has picked up major pace owing to the ...
Psychiatry healthcare professionals gain a thorough knowledge base of psychiatric disorder information to offer the best patient care. Get our FREE app now.
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Nolan on peripheral vascular disease nursing diagnosis: We prefer to use the term pad now but when people use the older term, pvd, they mean the same thing. for topic: Peripheral Vascular Disease Nursing Diagnosis
This thesis presents clinical and experimental studies relating to the effect of cigarette smoking on lipolysis in subjects with various types of vascular disease. The introduction reviews the evidence of the harmful effects of cigarette smoking and for its possible contribution to vascular disease through its action on lipid metabolism via the sympathetic adreno-medullary systems. The aims of the study are then outlined with respect to the effect of smoking varying numbers of cigarettes on levels of free fatty acids (FFA), ketone bodies (aceto-acetate and D hydroxybutyrate), glucose, insulin, cholesterol and triglyceride in subjects with either stable coronary heart disease (CFD) as manifest by angina or with peripheral vascular disease (PVD). The standard situation studied was serial venous sampling under controlled conditions before and after the smoking of two normal nicotine content cigarettes. Initial investigations indicated that a satisfactory steady state was achieved prior to smoking. ...
Upper extremity vascular disease is not common, when compared to lower extremity vascular disease, but has very different kind of diagnostic challenge for physicians.. The most well-known reasons for Upper extremity vascular disease are:. ...
What is Vascular Health?. Vascular health is about strengthening your heart and lungs so they perform at their optimal levels. After the age of 55 we are naturally at a higher risk for heart attacks, strokes, high cholesterol, high blood pressure, and peripheral artery disease (P.A.D.). When we live a sedentary life, these problems become even more of a risk. Obesity plays a huge role in causing many of these life-threatening diseases, but there is something you can do about it. Exercising for 30 minutes every day can help stave off these conditions.. Which Exercises Improve Vascular Health?. Cardio exercises, such as running, playing sports or any exercise that gets your heart rate up are considered great for the vascular and respiratory systems. When you put this kind of healthy, controlled stress on your heart and lungs, like any other muscle, they will become stronger. When these organs are strong, they are more able to fight off potential diseases. Typically an exercise that gets your heart ...
Morton Plant Hospital diagnoses, screens and treats for peripheral vascular disease (PVD) and peripheral arterial disease (PAD). Both diseases stem from build up in veins and arteries increasing the risk for heart attack or stroke.
Official journal of the International Society of Vascular Health (ISVH)Indexed:EmBase, Scopus and the Elsevier Bibliographic databasesAmerican Chemical Societys Chemical Abstracts Service (CAS)MedLinePubMedISSN 1176-6344 (Print)ISSN 1178-2048 (Online)An international, peer-reviewed journal of therapeutics and risk management, focusing on concise rapid reporting of clinical studies on the processes involved in the maintenance of vascular health; the monitoring, prevention, and treatment of vascular disease and its sequelae; and the involvement of metabolic disorders, particularly diabetes. In addition, the journal will also seek to define drug usage in terms of ultimate uptake and acceptance by the patient and healthcare professional.Key BenefitsConcise rapid reportingClinical therapeutics and pharmacology focusCardiovascular and metabolic disordersAims and scopeSubject areas include:Endothelial function, inflammation, biochemical and cellular processes, markers, coagulation disorders, and
A systematic review and meta-regression analysis found that statin and nonstatin therapies that act primarily through upregulation of low-density lipoprotein (LDL) receptor expression were associated with similar reductions in LDL cholesterol and relative risks of major vascular events.
If your patient is receiving drug therapy, monitor the effects of the prescribed drugs. Assess the neurovascular status of his legs and report any deterioration in circulation.. Place lambs wool between the patients toes to prevent pressure necrosis. If he has ulcers, provide wound care as needed. Assess the ulcer for signs and symptoms of infection. Cover the ulcer with a dry sterile dressing, topical antibiotic, or other wound care product, as ordered.. If your patient has had surgery for peripheral vascular disease, check his leg for color, temperature, sensation, movement, and pulses during the immediate postoperative period. Report any loss of pulse immediately. Observe the incision site for redness, swelling, and drainage.. Turn and reposition your patient every 2 hours. Tell him to not cross his legs and to avoid severe hip or knee flexion. To aid circulation, add a foot-board to the bed, use a sheepskin under his legs, or place him on an air, pressure, or other special mattress.. If ...
Peripheral vascular disease (PVD) is when blood vessels not located near the heart or brain narrow, inhibiting blood flow and causing pain.
Peripheral Vascular Disease (PVD) is a blockage or narrowing of the blood vessels outside of the heart and brain that gets worse over time.
Trusted information on peripheral vascular disease (also known as peripheral artery disease) including what it is, causes, diagnosis, symptoms, and treatments
Finden Sie alle Bücher von Gautam V. Shrikhande - Diabetes and Peripheral Vascular Disease. Bei der Büchersuchmaschine können Sie antiquarische und Neubücher VERGLEICHEN UND SOFORT zum Bestpreis bestellen. 162703157X
Finden Sie alle Bücher von Gautam V. Shrikhande - Diabetes and Peripheral Vascular Disease. Bei der Büchersuchmaschine können Sie antiquarische und Neubücher VERGLEICHEN UND SOFORT zum Bestpreis bestellen. 9781627031578
The diagnosis and management of peripheral vascular disease in primary care, including methods to manage cardiovascular risk for these patients and optimal therapies to reduce side-effects.
Peripheral vascular disease information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Millions of people in the United States have a circulatory problem of the legs called peripheral vascular disease. It can be painful and may even require surgery in serious cases. This disease can lead to severe skeletal ...
The latest report from Fore Pharma, Peripheral Vascular Disease Pipeline Highlights - 2017, provides most up-to-date information on key pipeline products in the ...
Author:Parul Vadgama, Mehul Bhavsar, Kusum V Shah, Rajesh Solanki, Ramakant Dixit, Jignesh Vaishnani. Keywords:Collagen vascular disease, pulmonary symptoms, sceroderma, rheumatoid arthritis. Type:Original Article. Full PDF Abstract ...
Author:Parul Vadgama, Mehul Bhavsar, Kusum V Shah, Rajesh Solanki, Ramakant Dixit, Jignesh Vaishnani. Keywords:Collagen vascular disease, pulmonary symptoms, sceroderma, rheumatoid arthritis. Type:Original Article. Full PDF Abstract ...
Amidst the continuing COVID-19 pandemic, concerns have mounted in the vascular community about the disruption to clinical routine.
The National Vascular Disease Prevention Alliance (NVDPA) is a group of four leading health organisations who are working together to reduce the burden of cardiovascular disease in Australia.
The worlds leading voices in the fight against Pulmonary Hypertension have compiled a special publication detailing the breakthrough research into the causes of this debilitating vascular disease.
Types of heart and vascular diseases and conditions affecting the heart, valves, arteries, veins, and the hearts electrical system.
Citation Machine™ helps students and professionals properly credit the information that they use. Cite your interview in Diabetes & Vascular Disease Research format for free.
Citation Machine™ helps students and professionals properly credit the information that they use. Cite your multivolume work in Diabetes & Vascular Disease Research format for free.
This statistic displays the share of the population suffering from stroke, heart and vascular diseases in Tasmania from 2004 to 2015.
Mesocardia & Normal Electrocardiogram & Vascular Disease Symptom Checker: Possible causes include Corrected Transposition of the Great Vessels. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
​Written by experts in the field Comprehensive approach to geriatric vascular disease Provides a step-by-step guide to surgical techniques
West Chester resident Mary Taylor gets screened for vascular diseases at the UC Heart and Vascular Centers free screening event. is provided by the Society for Vascular Surgery and includes a wealth of information and resourses for Vascular Health Professionals and Vascular Patients
Vascular Health focuses on the care of the circulatory system, which moves blood throughout the body. Arteries carry blood from the heart to vital organs and limbs, and veins return blood back to the heart.
NO SUPPLEMENTS NEEDED..Do you want to look vascular and have great pumps in the gym? This video will give you such 4 products which values under rs 10 and increases your vascularity and pump ... - Natural Health Resource - The worlds most widely referenced, open access, natural medicine database, with 30,000+ study abstracts and growing daily
By default, all articles on are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
If your patient is receiving drug therapy, monitor the effects of the prescribed drugs. Assess the neurovascular status of his legs and report any deterioration in ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Society for Vascular Surgery: Its Never Been More Important to Manage Stress Levels ROSEMONT, Ill., April 20, 2020 - Americans stress levels are through the r
Smoking related pulmonary vascular disease has been demonstrated to be an independent predictor of morbidity and mortality in patients with COPD. Previous inves...
Age equal to or greater than 50 years with established clinical vascular disease, or age equal to or greater than 55 years and subclinical vascular disease or age equal to or greater than 60 years and at least 2 or more cardiovascular risk ...
Vascular studies work by checking the blood flow in the veins and arteries. They are non-invasive in nature as they use ultrasound to measure the amount and the flow in your vessels.
Zhou Lijuan, Yang Wansong, Wang Weiqun, et al. Department of Cardiology, Second hospital of Tianjin Medical University, Tianjin 300211 ...
The vascular exams are performed by Registered Vascular Technologists (RVT) specializing in vascular testing, and consist of various testing options.
Abbott Vascular, a division of Abbott, is a global leader in cardiac and vascular care with market-leading products and an industry-leading pipeline.
Abbott Vascular, a division of Abbott, is a global leader in cardiac and vascular care with market-leading products and an industry-leading pipeline.
Get answers to your questions fast by checking out this list of FAQ ranging anywhere from who is more at risk for heart disease to its potential causes.
Disclaimer : The stories and articles are provided as a service. Dr Sandys opinions are for information only, and are not intended to diagnose or prescribe. For your specific diagnosis and treatment, consult your doctor or health care provider. ...
In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium. Along with acting as a semi- ... Endothelial dysfunction may be involved in the development of atherosclerosis[3][4] and may predate vascular pathology.[3][5] ... Kuvin JT, Mammen A, Mooney P, Alsheikh-Ali AA, Karas RH (Feb 2007). "Assessment of peripheral vascular endothelial function in ... Cohn JN, Duprez DA, Finkelstein SM (2009). "Comprehensive noninvasive arterial vascular evaluation". Future Cardiology. 5 (6): ...
Cerebrovascular diseases}}. Medicine. CNS disease, Vascular disease: Cerebrovascular diseases (G45-G46 and I60-I69, 430-438). ... Vascular diseases}}. Medicine. Cardiovascular disease: vascular disease · Circulatory system pathology (I70-I99, 440-456). ... Infectious disease templates. Footer. Pathology. Viral disease. {{Zoonotic viral diseases}}. Medicine. Zoonotic viral diseases ... Infectious disease templates. Footer. Pathology. Viral disease. {{Viral systemic diseases}}. Medicine. Infectious diseases - ...
"Annals of Vascular Diseases. 3 (1): 84-86. doi:10.3400/avd.AVDhdi08023. ISSN 1881-641X. PMC 3595814 . PMID 23555395.. ... Pathological anastomosis results from trauma or disease and may involve veins, arteries, or intestines. These are usually ... "The Use of Enclose®II Anastomosis Assist Device for the Proximal Coronary Branch Anastomosis to Vascular Graft" ...
Sanjay Rajagopalan; Debabrata Mukherjee; Emile R. Mohler (31 August 2004). Manual of Vascular Diseases. Lippincott Williams & ... A.R. Genazzani (15 May 2001). Hormone Replacement Therapy and Cardiovascular Disease: The Current Status of Research and ...
"Chapter 18: History, Physical Examination, and Diagnostic Approach". Manual of Vascular Diseases. Sanjay Rajagopalan, Debabrata ... ISBN 978-0-7817-4499-7. Assessment of the Elderly Patient: The Peripheral Vascular Examination: Venous Examinations at Medscape ...
Furie B, Furie BC (2007). "Cancer-associated thrombosis". Blood Cells, Molecules & Diseases. 36 (2): 177-81. doi:10.1016/j.bcmd ... Mackman N (June 2004). "Role of tissue factor in hemostasis, thrombosis, and vascular development". Arteriosclerosis, ... Engelmann B (2007). "Initiation of coagulation by tissue factor carriers in blood". Blood Cells, Molecules & Diseases. 36 (2): ... Thrombosis, and Vascular Biology. 24 (6): 1015-22. doi:10.1161/01.ATV.0000130465.23430.74. PMID 15117736.. ...
Diehm, C.; Allenberg, J.-R.; Nimura-Eckert, K.; Veith, F. J. (2013-11-11). Color Atlas of Vascular Diseases. Springer Science ... In 2008, the US had an estimate of 16 million atherosclerotic heart disease and 5.8 million strokes. Cardiovascular diseases ... Atherosclerosis, the primary cause of coronary artery disease (CAD) and stroke, is a disorder with multiple genetic and ... thickening of arterial walls and degenerative nature of the disease.[5][6] ...
Vascular disease. *Gangrene. Other. *Palpitations *Apex beat. *Cœur en sabot. *Jugular venous pressure *Cannon A waves ...
The term is sometimes also applied to physiological states outside the context of disease, as for example when referring to " ... Some symptoms occur in a wide range of disease processes, whereas other symptoms are fairly specific for a narrow range of ... Constitutional or general symptoms are those related to the systemic effects of a disease (e.g., fever, malaise, anorexia, and ... Non-specific symptoms are self-reported symptoms that do not indicate a specific disease process or involve an isolated body ...
Vascular lesions[edit]. These result from injury to the vascular endothelium. Causes:. Venoocclusive disease: Chemotherapeutic ... Toxic liver disease. Toxin induced liver disease. Drug induced liver disease. Drug induced liver damage. Drug induced liver ... Diseases of the liver. Philadelphia: JB Lippincott. pp. 813-45.. *^ Sarich TC, Adams SP, Petricca G, Wright JM (1999). " ... Zimmerman HJ (1978). "Drug-induced liver disease". Drugs. 16 (1): 25-45. doi:10.2165/00003495-197816010-00002. PMID 352664.. ...
Most commonly, intermittent (or vascular or arterial) claudication is due to peripheral arterial disease which implies ... Cardiology, Vascular surgery Intermittent claudication (Latin: claudicatio intermittens), also known as vascular claudication, ... Other uncommon causes are Trousseau disease,[medical citation needed] Beurger's disease (Thromboangiitis obliterans),[medical ... Vascular, Team (2015-01-31). "Intermittent Claudication Treatment India". VascularSurgery.. *^ National Institute for Health ...
Vascular disorders. *Vitamin C and vitamin K deficiency. *Von Willebrand's disease. *Hemorrhagic telangiectasia (Osler-Weber- ... U.S. Centers for Disease Control Published 2001-05-11.. *^ a b c Wackym,, James B. Snow,... P. Ashley (2009). Ballenger's ... Connective tissue disease. *Drugs-aspirin, fexofenadine, warfarin, clopidogrel, prasugrel, isotretinoin, desmopressin and ... Chronic liver disease-cirrhosis causes deficiency of factor II, VII, IX,& X ...
Known vascular disease. *Markers of insulin resistance (PCOS, acanthosis nigricans)[25][26] ... Because the disease may be insidious, the diagnosis often is delayed. Effects of the disease may affect larger blood vessels (e ... a b c d Cotran, Kumar, Collins; Robbins Pathologic Basis of Disease, Saunders Sixth Edition, 1999; 913-26. ... This stage is often referred to as the "grey area".[1] It is not a disease; the American Diabetes Association says,[2] " ...
Vascular Diseases). Witzstrock, Baden-Baden 1974 (as editor with K. Credner). In the Medline database PubMed, Loogen is listed ... Once his interest in heart disease was aroused - apparently by the endocarditis cases in the prisoner-of-war camp - and he was ... Later, coronary heart disease, cardiomyopathies and electrotherapy (pacemakers) were added. Loogen recognised early on that ... Habilitation thesis) Angeborene Herz- und Gefässfehler (Congenital heart and vascular defects). In: Röntgendiagnostik des ...
Travel Medicine and Infectious Diseases; Urgent Care Center; Urology; Vascular Screenings; Vascular Surgery; Wellness and ... Vascular Screenings; and Vascular Surgery. Livingston, New Jersey. Its 50,000 square-foot medical facility at 75 E. Northfield ... sinus disease and oncology. Its oncology trials include studies for breast cancer, colorectal cancer, leukemia, lung cancer, ...
"Vascular Dementia , Signs, Symptoms, & Diagnosis". Retrieved 2016-12-12. "NINDS , Parkinson's Disease Information ... Common areas of practice include loneliness in old age, depression, dementia, Alzheimer's disease, vascular dementia, and ... A geriatric psychologist aids in the assessment, diagnosing, treatment, and research of vascular dementia. Parkinson's disease ... and research of the disease. Vascular dementia, the second most common type of dementia, is the result of a stroke. Often times ...
"Pulmonary vascular disease in adults with congenital heart disease". Circulation. 115 (8): 1039-50. doi:10.1161/CIRCULATIONAHA. ... Hematologic diseases: chronic hemolytic anemia (including sickle cell disease). *Systemic diseases: sarcoidosis, pulmonary ... Metabolic disorders: glycogen storage disease, Gaucher disease, thyroid diseases. *Others: pulmonary tumoral thrombotic ... If heart disease and lung disease have been excluded, a ventilation/perfusion scan is performed to rule out CTEPH. If unmatched ...
Microvascular disease[edit]. Main article: Microangiopathy. Vascular and neural diseases are closely related. Blood vessels ... Diseases of the endocrine system (ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases - Endocrine diseases, E00- ... As the disease progresses, neuronal dysfunction correlates closely with the development of blood vessel abnormalities, such as ... a systematic analysis for the Global Burden of Disease Study 2010". Lancet. 380 (9859): 2163-96. doi:10.1016/S0140-6736(12) ...
"Diabetes & Vascular Disease Research. 14 (5): 400-406. doi:10.1177/1479164117715854. ISSN 1752-8984. PMC 5600262. PMID 28844155 ... Diseases of the endocrine system (ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases - Endocrine diseases, E00- ... with an increased risk of cognitive dysfunction and dementia through disease processes such as Alzheimer's disease and vascular ... Thrombosis and Vascular Biology, Council on Cardiovascular Disease in the, Young.; American Diabetes, Association. (August 2012 ...
Steiner G (December 2007). "Atherosclerosis in type 2 diabetes: a role for fibrate therapy?". Diabetes & Vascular Disease ... and a family history of early heart disease, but have not yet developed clinically evident coronary artery disease.[18] ... "Arteriosclerosis, Thrombosis, and Vascular Biology. 15 (5): 678-82. doi:10.1161/01.ATV.15.5.678. PMID 7749881.. ... Cardiovascular disease[edit]. *Primary prevention of heart attack, stroke, and need for revascularization procedures in ...
Extracranial cerebral and facial vascular disease.. *Thyroid gland abnormalities.. *Various other neoplastic, metabolic, and ... "FLIR infrared cameras help detect the spreading of swine flu and other viral diseases". 29 April 2009. ...
Diabetic Eye Disease John F., Salmon (2020). "Retinal vascular disease". Kanski's clinical ophthalmology : a systematic ... "WHO , Priority eye diseases". WHO. Retrieved 2020-09-02. Coursey, Terry G; de Paiva, Cintia S (2014-08-04). "Managing Sjögren's ... Sjögren's syndrome, a chronic autoimmune inflammatory disease that destroys moisture producing glands, including lacrimal gland ... Hypervitaminosis A John F., Salmon (2020). "Acquired macular diseases". Kanski's clinical ophthalmology : a systematic approach ...
It increases the risk of ischemic heart disease, strokes, peripheral vascular disease, and other cardiovascular diseases, ... Fisher ND, Williams GH (2005). "Hypertensive vascular disease". In Kasper DL, Braunwald E, Fauci AS, et al. (eds.). Harrison's ... For people who have experienced cardiovascular disease or those who are at a 10-year risk of cardiovascular disease of greater ... vascular rupture, and hemorrhagic stroke. Fullness disease was presumed to be due to an excessive amount of blood within the ...
Perera GA (1955). "Hypertensive vascular disease; description and natural history". J Chronic Dis. 1 (1): 33-42. doi:10.1016/ ... is typically transient as the vascular disease tends to resolve and renal perfusion improves over one to three months. ... This level of BP control will allow gradual healing of the necrotizing vascular lesions. More aggressive hypotensive therapy is ... such as stroke or coronary disease). Once the BP is controlled, the person should be switched to medication by mouth, with the ...
He was author of the standard Textbook of vascular medicine, Peripheral Vascular Diseases, first published in 1946, and served ... "Peripheral vascular diseases". Edgar van Nuys Allen along with associates in the Mayo Clinic and Mayo Foundation; 2nd edition, ... Edgar Allen was a specialist in cardiovascular medicine, and particularly known for his research of peripheral vascular disease ... Appio MR, Swan KG (February 2011). "Edgar Van Nuys Allen: The Test Was Only the Beginning". Annals of Vascular Surgery. 25 (2 ...
Peripheral vascular disease; femoral artery stenosis Renal artery stenosis Stroke, carotid artery stenosis Aortic aneurysm ... disease, goitre Paget's disease Polymyalgia rheumatica Giant cell arteritis Fibromuscular dysplasia IgG4-related disease ... Bruit, also called vascular murmur, is the abnormal sound generated by turbulent flow of blood in an artery due to either an ... CS1 maint: discouraged parameter (link) "bruit" at Dorland's Medical Dictionary "vascular murmur" at Dorland's Medical ...
Fisher ND, Williams GH (2005). "Hypertensive vascular disease". In Kasper DL, Braunwald E, Fauci AS, et al. (eds.). Harrison's ...
Mutation at the 6th position of the beta chain is the cause of sickle cell disease. Due to sickle cell disease, vascular ... Patient may have history of sickle cell disease. External eye examination may show comma sign in the conjunctiva. Vascular ... John F, Salmon (13 December 2019). "Retinal vascular disease". Kanski's clinical ophthalmology : a systematic approach (9th ed ... Retinopathy can occur in sickling hemoglobinopathies like sickle cell disease, sickle cell C disease, and sickle cell ...
475). Philadelphia: WB Saunders ISBN 0-7216-9653-8 Creager, M.A. & Dzau, V.J. (2005). Vascular diseases of the extremities. In ... Acrocyanosis may be a sign of a more serious medical problem, such as connective tissue diseases and diseases associated with ... 1490). New York: McGraw-Hill ISBN 0-07-140235-7 (2006). Peripheral vascular disorders. In R.S. Porter, T.V. Jones, & M.H. Beer ... The normal peripheral pulses rule out peripheral arterial occlusive disease, where arterial narrowing limits blood flow to the ...
Mandel J, Taichman D (2006). Pulmonary Vascular Disease. Elsevier Health Sciences. p. 170. ISBN 978-1416022466. Ferri FF (2015 ... Rh disease, one of the causes of hemolytic disease of the newborn Transfusion reaction to blood transfusions Mechanical trauma ... Inflammatory bowel disease. There are a number of definitions of anemia; reviews provide comparison and contrast of them. A ... They are not recommended in people with chronic kidney disease unless hemoglobin levels are less than 10 g/dL or they have ...
... the cholesterol with the strongest links to vascular diseases. In studies using standard doses, statins have been found to ... Pollack, Andrew (29 January 2013) F.D.A. Approves Genetic Drug to Treat Rare Disease The New York Times, Retrieved 31 January ...
MacDonald BT, Tamai K, He X (July 2009). "Wnt/β-catenin signaling: components, mechanisms, and diseases". Dev. Cell. 17 (1): 9- ... Yi ZY, Feng LJ, Xiang Z, Yao H (2011). "Vascular endothelial growth factor receptor-1 activation mediates epithelial to ... Mice engineered to specifically have vascular endothelium cells deficient in β-catenin showed disrupted adhesion between ... conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular ...
Nerve growth factor circulating levels are increased in Kawasaki disease: correlation with disease activity and reduced ... and Vascular Biology, 2012; 32: e60-e71 ... Induced Coronary Arteritis in a Mouse Model of Kawasaki Disease ...
Cardiology, atherosclerosis and vascular disease study: In clinical cardiology, FDG-PET can identify so-called "hibernating ... Infectious diseasesEdit. Imaging infections with molecular imaging technologies can improve diagnosis and treatment follow-up. ... March 1999). "In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease". Neurology. 52 (4): ... where the risk to the patient from lack of knowledge about disease progress is much greater than the risk from the test ...
The mortality rate of Cushing's disease was reported to be 10-11%,[19][22] with the majority of deaths due to vascular disease[ ... The disease is often diagnosed 3-6 years after the onset of illness.[19] Several studies have shown that Cushing's disease is ... Cases of Cushing's disease are rare, and little epidemiological data is available on the disease. An 18-year study conducted on ... Cushing disease, tertiary or secondary hypercortisolism, tertiary or secondary hypercorticism, Itsenko-Cushing disease[1][2]. ...
List of systemic diseases with ocular manifestations. References[edit]. *^ a b c Matejcek, A; Goldman, RD (November 2013). " ... The disease incidence varies widely depending on the geographical location. The most extensive epidemiological survey on this ... "Red Book-Report of the Committee on Infectious Diseases, 29th Edition. The American Academy of Pediatrics". Retrieved 2007-07- ... In addition to the incidence of this sight threatening infection they also investigated the time trends of the disease. ...
SP concentrations cannot yet be used to diagnose disease clinically or gauge disease severity. It is not yet known whether ... "Substance P enhances cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) expression on cultured rheumatoid fibroblast- ... Microbial Toxins and Diarrhoeal Disease. Ciba Found. Symp. 112. pp. 139-54. doi:10.1002/9780470720936.ch8. PMID 2861068.. ... Quantification in diseaseEdit. Elevation of serum, plasma, or tissue SP and/or its receptor (NK1R) has been associated with ...
Graft-versus-host disease[edit]. Main article: Graft-versus-host disease. Graft-versus-host disease (GVHD) is an inflammatory ... Veno-occlusive disease[edit]. Severe liver injury can result from hepatic veno-occlusive disease (VOD). Elevated levels of ... Major complications are veno-occlusive disease, mucositis, infections (sepsis), graft-versus-host disease and the development ... Autoimmune diseases[9]. Many recipients of HSCTs are multiple myeloma[10] or leukemia patients[11] who would not benefit from ...
listen)) is the science and practice of the diagnosis, treatment, and prevention of disease.[4][5] The word "medicine" is ... vascular surgery, and pediatric surgery. In some centers, anesthesiology is part of the division of surgery (for historical and ... Preventive medicine is the branch of medicine concerned with preventing disease. *Community health or public health is an ... Pathology as a medical specialty is the branch of medicine that deals with the study of diseases and the morphologic, ...
... a fluctuating course of disease severity, the eyes being closed during a seizure, and side to side head movements. Features ... the DSM-5 was updated to add emphasis to the positive physical signs inconsistent with recognized diseases. The requirement of ... Huntington's disease. *Mild cognitive impairment. *Parkinson's disease. *Pick's disease. *Sundowning. *Vascular dementia ... they are considered a subtype of a larger category of psychiatric disease. ...
... differentiation and disease". Nature Reviews. Endocrinology. 11 (1): 29-42. doi:10.1038/nrendo.2014.186. PMID 25350068.. ... present in a solid/nested growth pattern and frequently involve vascular invasion. It has been observed that PAX8/PPAR y- ... "Pax genes in renal development, disease and regeneration". Seminars in Cell & Developmental Biology. Paramutation & Pax ...
... subluxation is the sole cause of disease and manipulation is the cure for all diseases of the human race.[4][41] A 2003 ... Ernst E (2010). "Vascular accidents after neck manipulation: cause or coincidence?". Int J Clin Pract. 64 (6): 673-77. doi: ... Palmer, a magnetic healer, hypothesized that manual manipulation of the spine could cure disease.[214] The first chiropractic ... A subluxated vertebra ... is the cause of 95 percent of all diseases ... The other five percent is caused by displaced joints ...
Significant diseases. Cancer, bone fractures. Significant tests. screening tests, X-ray, CT, MRI, PET, bone scan, ...
Colorectal Disease. 10 (8): 789-792. doi:10.1111/j.1463-1318.2007.01381.x. PMID 17868406.. ... Peripheral vascular examination. *Heart sounds. *Other *Abdominojugular test. *Ankle-brachial pressure index ... which may be useful in case of fecal incontinence or neurologic diseases, including traumatic spinal cord injuries; ... acute abdominal symptoms indicating a serious underlying disease). Although a Journal of Emergency Medicine paper concludes: " ...
Hourigan CS (2006). "The molecular basis of coeliac disease". Clin Exp Med (Review). 6 (2): 53-59. doi:10.1007/s10238-006-0095- ... Spetzler RF, Sanai N (2012). "The quiet revolution: Retractorless surgery for complex vascular and skull base lesions". Journal ... GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national ... Hodgson TS, Nielsen SM, Lesniak MS, Lukas RV (2016). "Neurological Management of Von Hippel-Lindau Disease". Neurologist ( ...
"PLoS Neglected Tropical Diseases. 6 (9): e1839. doi:10.1371/journal.pntd.0001839. PMC 3459880 . PMID 23029594.. ... This is because the virus has an affinity for the placenta and other highly vascular tissues. The fetus has only a one in ten ... Descriptions of the disease date from the 1950s.[1] The virus was first described in 1969 from a case in the town of Lassa, in ... The disease is usually initially spread to people via contact with the urine or feces of an infected multimammate rat.[1] ...
... and systemic diseases that occur as a result of kidney disease, such as renal osteodystrophy and hypertension. A physician who ... temporary vascular access lines, tunnelled vascular access lines, peritoneal dialysis access lines), fistula management ( ... the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease ... Many diseases affecting the kidney are systemic disorders not limited to the organ itself, and may require special treatment. ...
... allowing both the buds and vascular cambium to be insulated from the intense heat.[4] It should however be noted that not all ... will sometimes send out epicormic shoots when they are dying from the disease.[7] Similarly, ash trees may develop epicormic ...
"Global Burden of Disease". W.H.O. Global Burden of Disease/en/. Retrieved 7 October 2015.. ... skin disease constituted approximately 2% of total global disease disability [36] as measured in disability adjusted life years ... "Disease List - U of U School of Medicine - , University of Utah". Retrieved 2017-02-05.. ... Dermatology is the branch of medicine dealing with the skin, nails, hair ( functions & structures ) and its diseases.[1][2] It ...
"Arteriosclerosis, Thrombosis, and Vascular Biology. 33 (2): 285-93. doi:10.1161/ATVBAHA.112.300388. PMC 3557503 . PMID 23202364 ... Possible pregnancy, liver disease, high alcohol consumption, and smoking are indications for close monitoring and limitation of ... Gundermann KJ, Kuenker A, Kuntz E, Droździk M (2011). "Activity of essential phospholipids (EPL) from soybean in liver diseases ... hyena disease): a historical review of the human and veterinary literature". Pediatric Radiology. 37 (12): 1264-7. doi:10.1007/ ...
"Vascular changes in the bulbar conjunctiva associated with sickle-cell disease: some observations on fine structure". ... "Anatomical and physiological aspects of the capillary bed in the bulbar conjunctiva of man in health and disease". Angiology. 6 ... "Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease". American Journal of Hematology (ഭാഷ: ഇംഗ്ലീഷ്). 88 (8 ...
Invasive exotic diseasesEdit. History is rife with the spread of exotic diseases, such as the introduction of smallpox into the ... Energy from vascular plant wastewater treatment systems - Eichhornia crassipes, Spirodela lemna, Hydrocotyle ranunculoides, ... Diseases may also be vectored by invasive insects such as the Asian citrus psyllid and the bacterial disease citrus greening.[ ... Another example is the Dutch elm disease, which has severely reduced the American elm trees in forests and cities.[citation ...
The disease exists in both rapid and slow onsets, and involves inflammation of the gray matter of the bulb.[1] Infantile PBP is ... Wilson, John Eastman (1909). Diseases of the nervous system. Boericke & Runyon. p. 296. Retrieved 5 December 2017. Infantile ... a disease that manifests itself in two forms: Fazio Londe syndrome (FL) and Brown-Vialetto-Van-Laere syndrome (BVVL).[2] ...
These are more likely the result of vascular activity in these areas and are unlikely to be pathological. The development of ... Enamel hypoplasias generally form due to disease and/or poor nutrition. Linear furrows are commonly referred to as linear ... For example, bioarchaeologists have used caries in skeletons to correlate a diet of rice and agriculture with the disease. ... Disruptions in homeostasis caused by nutritional deficiency or disease or profound inactivity/disuse/disability can lead to ...
Diseases of the urinary system (N00-N39, 580-599). Kidney disease. Glomerules. ... Vascular. *Renal artery stenosis. *Renal ischemia. *Hypertensive nephropathy. *Renovascular hypertension. *Renal cortical ...
"Manual of Vascular Plants of Northeastern United States and Adjacent Canada, Second Edition." The New York Botanical Garden. ... Pests and diseasesEdit. Black knot infection. P. serotina is a host of caterpillars of various Lepidoptera (see List of ... Catálogo de las plantas vasculares de Bolivia, Monographs in systematic botany from the Missouri Botanical Garden 127(1-2): i- ...
Baizabal-Carvallo, JF; Jankovic J. (2012-07-18). "Movement disorders in autoimmune diseases". Movement disorders : official ...
Cerebrovascular disease-a group of vascular diseases that affect brain function.[citation needed] Vascular disease is a ... The physical exam may be different depending on the type of vascular disease. In the case of a peripheral vascular disease the ... Vascular disease is a class of diseases of the blood vessels - the arteries and veins of the circulatory system of the body. It ... "Vascular Diseases: MedlinePlus". Retrieved 2015-06-23. "How Is Peripheral Arterial Disease Treated? - NHLBI, ...
Vascular Disease Research is a peer-reviewed academic journal that publishes papers in the field of Peripheral vascular disease ... Diabetes and Vascular Disease Research is abstracted and indexed in, among other databases: SCOPUS, and the Social Sciences ... "Peripheral Vascular Disease" and 66 out of 116 journals in the category "Endocrinology & Metabolism". "Journals Ranked by ... Peripheral Vascular Disease". 2010 Journal Citation Reports. Web of Science (Sciences ed.). Thomson Reuters. 2011. "Journals ...
... medical and surgical treatments for pediatric retinal vascular conditions, which are l ... Pediatric Retinal Vascular Diseases. Autor: Spandau, Ulrich; Kim, Sang Jin Disponibilitate: LIVRARE IN 3-5 SAPTAMANI (produsul ... Ai adaugat Pediatric Retinal Vascular Diseases la lista ta de produse favorite.. * Continuati cumparaturile. ... Ai adaugat Pediatric Retinal Vascular Diseases in cosul de cumparaturi.. * Continuati cumparaturile. ...
... even in high-risk patients and in patients with known vascular disease. The combination of niacin and laropiprant, marketed as ... 9(November 1, 2014) / POEMs: Niacin Does Not Improve Clinical Outcomes in Patients with Vascular Disease ... Does niacin plus laropiprant improve cardiovascular outcomes or reduce mortality in patients with vascular disease? ... even in high-risk patients and in patients with known vascular disease. The combination of niacin and laropiprant, marketed as ...
Treating Peripheral Vascular Disease. Blood flow to the arms, legs and vital organs is essential for muscles and tissues to get ... Learn More About Our Peripheral Vascular Disease and Treatment. To learn more about our services and how we can help, please ... Cardiologists at Marians Heart Center are treating patients who suffer from Peripheral Vascular Disease (also known as PVD) ... you may experience the pain or numbness known as peripheral vascular disease. Marian Regionals Heart Center can help with ...
Chapter 93 Molecular Basis of Right Ventricular Hypertrophy and Failure in Pulmonary Vascular Disease ... Chapter 70 Pulmonary Arterial Hypertension Related to Scleroderma and Collagen Vascular Diseases ... Chapter 12 Acute Lung Injury: The Injured Lung Endothelium, Therapeutic Strategies for Barrier Protection, and Vascular ... Chapter 53 Carbon Monoxide and Heme Oxygenase in the Regulation of Pulmonary Vascular Function and Structure ...
Peripheral Vascular Disease (PVD) Global Clinical Trials Review, H1, 2018 ... Peripheral Arterial Disease (PAD)/ Peripheral Vascular Disease (PVD) Global Clinical Trials Review, H1, 2018. Summary. The ... Peripheral Arterial Disease (PAD)/Peripheral Vascular Disease (PVD) Global Clinical Trials Review, H1, 2018. * ID: 4559053 ... Peripheral Arterial Disease (PAD)/ Peripheral Vascular Disease (PVD) - Pipeline Review, H2 2020. * Drug Pipelines ...
More evidence that vascular disease plays a crucial role in age-related cognitive impairment and Alzheimers comes from data ... 2010). Longitudinal Changes in White Matter Disease and Cognition in the First Year of the Alzheimer Disease Neuroimaging ... Healthy diet could slow or reverse early effects of Alzheimers disease Following on from previous research with mice that ... Muted emotions misleading in Alzheimers disease A small study suggests that the apathy shown by many Alzheimers patients may ...
... different forms of vascular disease, progression of disease and effects on human body, ultimately causing deterioration in ... The course will focus on more advanced skills like differentiating venous vs arterial disease, in depth understanding of risk ... factors leading to disease and modifications, conservative treatment strategies to reverse or modify the disease process. ... vascular anatomy, atherosclerosis, lower extremity claudication pain, amputations. Intermediate level Instructor: Sharmila ...
Chapter 93 Molecular Basis of Right Ventricular Hypertrophy and Failure in Pulmonary Vascular Disease ... Chapter 70 Pulmonary Arterial Hypertension Related to Scleroderma and Collagen Vascular Diseases ... Chapter 12 Acute Lung Injury: The Injured Lung Endothelium, Therapeutic Strategies for Barrier Protection, and Vascular ... Chapter 53 Carbon Monoxide and Heme Oxygenase in the Regulation of Pulmonary Vascular Function and Structure ...
Acquired Cognitive Impairment... Aging... Alzheimers Disease... Alzheimers Disease including Alzheimers Disease Related ... Home » Database » Community based assessments regarding vascular contributions to Alzheimers Disease in M2OVE AD consortium ... PUBLIC HEALTH RELEVANCE: Although great advances have been made in understanding Alzheimers disease (AD), underlying vascular ... Community based assessments regarding vascular contributions to Alzheimers Disease in M2OVE AD consortium ...
... There are many vascular conditions that require clinical care by a physician or other health ... Pediatric Diseases and Conditions. * Home Page - Cardiovascular Disorders * Problems Affecting the Coronary Arteries and Blood ... Detailed information on vascular conditions and diseases ... Overview of the Vascular System. Medical Management of Vascular ...
The vascular system is the network of blood vessels that circulate blood to and from the heart and lungs. Vascular diseases are ... Vascular Disease Diagnosing Vascular Disease? Diagnosing Venous Disease and Pulmonary Embolism. Venous disease is diagnosed ... This procedure is performed by an interventional radiologist - a specialist who diagnoses and treats many vascular diseases and ... What Causes Vascular Disease?. *For more information on Vascular Disease visit. *For more information on Vascular Disease visit ...
Download Vascular Disease in Older Adults eBook for free in PDF or ePub format also read online ... Vascular Disease in Older Adults. This book presents a comprehensive and state-of the-art approach to vascular disease for the ... Vascular Disease in Older Adults Related Links Vascular Disease In Older Adults. ... With its concise yet comprehensive summary of the field, Vascular Disease in Older Adults is the ultimate resource for ...
... Full size800 × 800 Post navigation. Published in. Peripheral Vascular ...
Information on drugs commonly used to treat Collagen-vascular Disease ... List of Drugs Associated with Collagen-vascular Disease. Filter Table by Serious Outcome. ×. Filter by Serious Outcome. ... Drugs Treating Collagen-vascular Disease. *We do not have any related drugs for you. ...
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... peripheral vascular disease (balloon angioplasty, stents, bypass); Carotid arterial disease; Aortic aneurysms AAA ... Arterial disease treatment. As a vascular and endovascular surgeon, Mr Ling is highly trained in using a comprehensive array of ... with a vascular specialist who has a comprehensive skill set that employs the latest techniques in arterial disease treatment. ... treatment options for the management of arterial disease. These include minimally invasive endovascular techniques such as ...
... about these resources.... This is a collection of patient ...
Peripheral vascular disease involves disease or disorders of the circulatory system outside of the heart or brain. ... Vascular disease is more common than most people realize and it increases with age. ... Common disorders of this circulatory system include peripheral arterial disease and venous disease. How common? One in every 20 ... Texan Vein & Vascular is open and we will continue to see patients from 8am to 5pm. To ensure your safety and the safety of our ...
Learn about the symptoms of adventitial cystic disease and how the MedStar Heart & Vascular Institutes specialists treat it. ... Vascular Disease Treatments. Vascular disease treatments address conditions that affect the blood vessels, which can cause ... Adventitial cystic disease is a rare type of peripheral vascular disease in which a fluid-filled sac called a cyst forms next ... Expert care for a rare vascular disease. Expert Heart & Vascular Care. Getting the care you need starts with seeing one of our ...
Archives for Vascular disease Types of Vascular Disease. January 30, 2017. With every beat of your heart, blood is pumped ... Types of Vascular Disease There are many types of vascular disease. Some conditions are severe and must be handled immediately ... Carotid Artery Disease. What is Carotid Artery Disease? Carotid artery disease is a disease in which fatty deposits, called... ... Learn about Peripheral Artery Disease!. Peripheral Artery Disease (PAD) is a very common disease in which plaque builds up in ...
Peripheral Vascular Disease. What is Peripheral Vascular Disease?. Peripheral Vascular Disease (PVD) or Peripheral Arterial ... What are some symptoms of Peripheral Vascular Disease?. Symptoms include tiredness or cramping in the leg muscles when walking ... Peripheral vascular procedures are performed most frequently in the legs, but can be in the arms, kidneys, pelvic area, and ... The blockage or narrowing of the blood vessels is often caused by a disease called atherosclerosis. Atherosclerosis is when ...
Peripheral Vascular Disease (PVD) are diseased blood vessels that cause a problem in your circulatory system which leads to ... What is Peripheral Vascular Disease (PVD). Peripheral Artery Disease (PVD) are diseased blood vessels that cause a problem in ... What is Peripheral Vascular Disease (PVD). by DrCiuffo , Jun 23, 2016 , Blog, Peripheral Artery Disease , 0 comments ... Surgery for Peripheral Vascular Disease in Canton, OH may be an option you want to consider to help aid your condition. You can ...
For Vascular Protection from Heart Vessel Disease, STOP Heart Attack Blockages Embolism Improve Perfusion, Bob Vineyard, Pure ... For Vascular Protection from Heart Vessel Disease, STOP Heart Attack Blockages Embolism Improve Perfusion, Bob Vineyard, Pure ...
Diabetic Foot Disease, Cerebrovascular Disease, Aortic Aneurysmal Disease ... Dr Korana Musicki sees Arterial Disease patients with Peripheral Vascular Disease, ... Peripheral Vascular Disease. Peripheral arteries are most commonly used to describe the blood vessels carrying oxygen and ... Diabetic Foot Disease. Diabetes can cause damage to arteries and nerves of the feet and legs. This puts diabetic feet at an ...
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  • Atherosclerosis - a disease in which plaque builds up inside your arteries. (
  • Atherosclerosis is a disease in which fatty plaques form in the inside walls of blood vessels. (
  • Glycosaminoglycans administration (heparan sulphate, dermatan-sulphate and their combinations 50:50) and reduction of atherosclerosis progression rate in rabbits with a diet-induced hypercholesterolemia," Atherosclerosis and Cardiovascular Disease , vol. 4, pp. 971-975, 1989. (
  • Types of vascular disease include atherosclerosis , the hardening or narrowing of the arteries due to plaque buildup, and peripheral artery disease , the narrowing of the arteries in the limbs. (
  • Alternatively, it can develop as an important accompanying comorbidity (steroid-related atherosclerotic disease), or represent the synergistic pathogenetic outcome of augmented atherosclerosis within a proinflammatory environment. (
  • Over the years, I have been asked about chelation therapy for atherosclerosis, particularly in preventing heart attacks and peripheral vascular diseases. (
  • Unresolved inflammation is central to the pathophysiology of commonly occurring vascular diseases such as atherosclerosis, aneurysm, and deep vein thrombosis - conditions that are responsible for considerable morbidity and mortality. (
  • Knowledge and understanding of vascular disease, particularly atherosclerosis, continue to expand across disciplines, as do diagnostic and therapeutic strategies for treatment of vascular disorders. (
  • Atherosclerosis - the buildup of fats and cholesterol on the artery walls that can lead to stroke and heart disease - is generally considered a problem of modern times, a result of fatty diets and inactive lifestyles. (
  • Buerger's disease, which occurs almost exclusively in heavy smokers, is different from peripheral arterial disease (PAD) in that it is not caused by atherosclerosis (plaque buildup in the arteries). (
  • Peripheral arterial disease and progression of coronary atherosclerosis. (
  • Renal artery disease is usually caused by atherosclerosis, hardening of the arteries due to the build up of fatty deposits or plaques along the artery wall. (
  • We know from community studies that peripheral vascular disease is really very common, and the reason it's important is because atherosclerosis, which is the underlying cause [of peripheral vascular disease], is a condition which doesn't affect one part of the body. (
  • Atherosclerosis in Association With Diabetes With the possible exception of cancer, no field of clinical investigation is receiving more attention than that of degenerative vascular disease. (
  • Carotid artery disease occurs when the main blood vessels to the brain develop a buildup of plaque caused by atherosclerosis. (
  • LITTLE FALLS, N.J., June 15 -- Patients with psoriasis are at increased risk for atherosclerosis and accompanying vascular diseases, researchers found. (
  • Here, we show that deficiency of one or two alleles of ATM, the protein mutated in the cancer-prone disease ataxia telangiectasia, worsens features of the metabolic syndrome, increases insulin resistance, and accelerates atherosclerosis in apoE-/- mice. (
  • The more risk factors for vascular disease one has in middle age, the higher the risk may be of developing Alzheimer's disease in later life. (
  • Vascular disease is a class of diseases of the blood vessels - the arteries and veins of the circulatory system of the body . (
  • Peripheral artery disease - happens when atheromatous plaques build up in the arteries that supply blood to the arms and legs, plaque causes the arteries to narrow or become blocked. (
  • Vascular disease is a pathological state of large and medium muscular arteries and is triggered by endothelial cell dysfunction. (
  • Both veins and arteries may be affected, but the disease is usually arterial. (
  • SecondsCount/The Society for Cardiovascular Angiography and Interventions: "Peripheral Vascular Disease: How Problems with Arteries & Veins Affect Legs, Brain & Kidneys. (
  • In 1904 Thayer found a high frequency of arterial lesions in patients who died from typhoid fever and a high prevalence of arteriosclerotic radial arteries in those who survived.6 Liuba and his group found that infections in early life are a risk factor for vascular disease. (
  • Osler W. Diseases of the arteries. (
  • Buerger's disease, also called thromboangitis obliterans, is a rare form of vasculitis characterized by acute inflammation and clotting of the arteries and veins of the hands and feet. (
  • Carotid Artery Disease - The carotid arteries carry blood to the brain. (
  • Peripheral Arterial Disease (PAD) - A buildup of plaque within the arteries that supply oxygen-rich blood to your limbs and pelvis. (
  • This ranges from diseases of your arteries, veins and lymph vessels to blood disorders that affect circulation. (
  • A blockage in the renal arteries can cause renal artery disease (stenosis). (
  • Buerger's Disease most commonly affects the small and medium sized arteries, veins, and nerves. (
  • Diabetic arterial disease typically affects smaller arteries - including those that lead to the eyes, kidneys, fingers, feet, and toes - causing nerve and circulation problems. (
  • Peripheral Vascular Disease (PVD) is an inflammatory disease of the peripheral arteries. (
  • When PVD specifically affects the arteries, it's called peripheral arterial disease. (
  • Peripheral vascular disease results from the progressive narrowing of arteries in the body and occurs secondary to a process known as atherosclerotic vascular disease. (
  • Peripheral vascular disease involves, for the most part, the arteries of the lower extremities. (
  • Procedures similar to angioplasty in the coronary arteries are starting to be applied by specially trained Radiologists in the treatment of lower extremity peripheral vascular disease. (
  • Existing devices for treating these patients have significant shortcomings that make it challenging to successfully open arteries, while minimizing vascular injury and complications. (
  • Buerger's disease - is due to small blood vessels that inflame and swell, vessels then narrow or are blocked by blood clots . (
  • Raynaud's disease - a rare peripheral vascular disorder of constriction of the peripheral blood vessels, in the fingers and toes when the person is cold. (
  • Your vascular system is your body's network of blood vessels. (
  • Peripheral vascular disease is a narrowing of blood vessels that restricts blood flow. (
  • Peripheral vascular disease includes a group of diseases in which blood vessels become restricted or blocked. (
  • Some disorders classified as collagen vascular disease affect your joints, skin, blood vessels, or other vital organs. (
  • Your blood vessels or the lining of your heart may become inflamed if you have this form of collagen vascular disease. (
  • Vascular diseases typically result from the hardening and narrowing of blood vessels and high blood pressure. (
  • They say this simple measure, which has been recommended for some time but not often used, can detect narrowing and hardening of the blood vessels that supply the legs and feet - a condition known as peripheral vascular disease or peripheral artery disease. (
  • Peripheral Vascular Disease Understand more about diseases and disorders of the blood vessels outside of the heart. (
  • Peripheral vascular disease (PVD) refers to diseases and disorders of the blood vessels outside of the heart, such as those of the brain, gut, kidneys, or limbs. (
  • We discovered an inhibitory switch that degrades blood vessels," said Narkar, whose laboratory is in the UTHealth Center for Metabolic and Degenerative Diseases at The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases. (
  • Not unlike Tolstoy's remark about happy versus unhappy families, current wisdom in vascular biology holds that healthy blood vessels are mostly similar, whereas vessels in different vascular diseases are mostly different. (
  • vascular disease of the legs causes narrowing of the blood vessels in the legs, which keeps the blood from flowing adequately through these vessels. (
  • It can be difficult to make a vascular disease diagnosis since there are a variety of symptoms that a person can have, also family history and a physical examination are important. (
  • The percentage of patients 18-75 years of age who had a diagnosis of ischemic vascular disease (IVD) and were on daily aspirin or anti-platelet medication, unless allowed contraindications or exceptions are present. (
  • Percentage of patients 18 years of age and older who were diagnosed with acute myocardial infarction (AMI), coronary artery bypass graft (CABG) or percutaneous coronary interventions (PCI) in the 12 months prior to the measurement period, or who had an active diagnosis of ischemic vascular disease (IVD) during the measurement period, and who had documentation of use of aspirin or another antiplatelet during the measurement period. (
  • However, it is this ambiguity and heterogeneity in terminology that necessitated further evaluation by the authors," who created this scientific statement "to serve as a guide to practitioners on the prevention, diagnosis, and treatment of vascular cognitive impairment," Grysiewicz said. (
  • Based on changes in oxygen saturation during the induced ischemia phase, a diagnosis is provided of whether a patient has or does not have peripheral vascular disease. (
  • providing a visual indication of a positive diagnosis of peripheral vascular disease on a display when a measured rate of change in the oxygen saturation during the induced ischemia phase crosses a threshold value. (
  • providing a visual indication of a positive diagnosis of peripheral vascular disease on a display when a measured time, from a starting time value to an ending time value, for the oxygen saturation to cross a percentage value exceeds a specific time value, wherein the ending time is within the induced ischemia phase. (
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (
  • While pulmonary hypertension is now less common with earlier diagnosis of congenital heart disease there still exists a significant population of adults with this debilitating illness. (
  • Gary Schaer, MD, an interventional cardiologist at Rush University Medical Center in Chicago, explains how peripheral vascular disease (also called peripheral arterial disease) is diagnosed and why diagnosis is so important. (
  • Your Loyola vascular surgeon will take the time to help you understand your diagnosis, offer you the most advanced treatment options available and work with you to develop a treatment plan that meets your needs and goals. (
  • Loyola's vascular team of doctors, nurses and other healthcare professionals have expertise in the diagnosis and treatment of vascular diseases. (
  • Coronary artery disease and carotid artery disease , diseases that involve the narrowing or blockage of an artery. (
  • on the other hand, inflammation or other vascular disorders (idiopathic cystic medial necrosis, syphilitic aortitis, primary coronary arteritis, coronary arteritis, Takayasu's arteritis) are rarer. (
  • Aufderheide A, Henke B, Parker E (1981) Granulomatous coronary arteritis (Takayasu disease). (
  • Hertzer NR, Beven EG, Young JR, et al: Coronary artery disease in peripheral vascular patients-a classification of 1000 coronary angiograms and results of surgical management. (
  • Bloombery PA, Ferguson A, Rosengarten DS, et al: Role of coronary artery disease in complications of abdominal aortic surgery. (
  • People with coronary artery disease (CAD) often also have PVD. (
  • Subclinical disease reached levels of 52% and was confirmed with a variety of techniques, such as carotid and brachial artery Doppler ultrasound, coronary artery angiography, and SPECT dual-isotope myocardial perfusion imaging [ 15 ]. (
  • In another retrospective study that evaluated data over 6 years from 23,870 index transfemoral vascular access procedures from cross-matching the Eastern Danish Heart Registry with the Danish Vascular Registry, Dencker et al noted a low risk of major vascular complications (0.54%) with femoral access following coronary angiography and percutaneous coronary intervention (PCI). (
  • Major femoral vascular access complications after coronary diagnostic and interventional procedures: A Danish register study. (
  • But those previous studies suffered from various limitations, including conflicting data, smaller sample sizes, the lack of distinction between people who were never married, divorced, or widowed, and a focus on coronary disease. (
  • The relationship with coronary disease was not significant. (
  • Coronary disease, for example, was 4.6% higher in those who were divorced and 7.1% higher among those who were widowed. (
  • Every year in Canada, strokes and coronary heart disease, also known as coronary artery disease, account for 18 million visits to physicians, eight million days spent in hospitals, and 36 per cent of all deaths nationwide. (
  • Chen CC, Hung KC, Hsieh IC, Wen MS. Association between peripheral vascular disease indexes and the numbers of vessels obstructed in patients with coronary artery disease. (
  • Meller SM, Stilp E, Walker CN, Mena-Hurtado C. The link between vasculogenic erectile dysfunction, coronary artery disease, and peripheral artery disease: role of metabolic factors and endovascular therapy. (
  • To investigate the value of the Edinburgh Claudication Questionnaire (ECQ) against the ankle-brachial index (ABI) in Canadian patients mainly followed in general practice, with documented acute coronary syndrome (ACS)/ischemic stroke (IS)/transient ischemic attack (TIA) and who are not known to have peripheral arterial disease (PAD) at the time of enrolment. (
  • Bell AD, Roussin A, Popovici-Toma D, Girard M, Chiu JF, Huckell V. The value of routine screening for peripheral arterial disease in stable outpatients with a history of coronary artery or cerebrovascular disease. (
  • Explain to interested patients that this study found that patients with psoriasis were more likely to have vascular disease beyond coronary artery disease and this was associated with a higher percentage of deaths. (
  • In patients with stable coronary artery disease , an independent and inverse association exists between n-3 fatty acid levels and inflammatory biomarkers. (
  • Fish and long-chain omega-3 fatty acid intake reduce the risk of coronary heart disease and total mortality in diabetic women. (
  • WASHINGTON -- Being married was associated with a lower likelihood of having various types of vascular disease compared with not having a spouse, a study of more than 3.5 million people showed. (
  • After adjustment for age, sex, race, and risk factors, being married -- versus having never married -- was associated with a lower likelihood of any vascular disease, in addition to specific types of vascular disease. (
  • There are many types of vascular disease. (
  • The highly skilled doctors at Loyola Medicine are experienced at treating many types of vascular disease, which encompasses any condition that affects the circulatory system. (
  • Antithrombotic therapy in peripheral artery disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (
  • Find overview articles and information on leg vein health conditions including chronic venous insufficiency, peripheral vascular disease and deep vein thrombosis, and discover what symptoms like leg swelling and swollen feet and ankles can indicate. (
  • Thank you for your interest in spreading the word on Arteriosclerosis, Thrombosis, and Vascular Biology. (
  • Your Name) thought you would like to see the Arteriosclerosis, Thrombosis, and Vascular Biology web site. (
  • It is a subgroup of cardiovascular disease . (
  • More than a hundred reviews have been published about the association between microorganisms and cardiovascular disease, but almost all authors consider their presence as a secondary phenomenon. (
  • Serological markers of infections, bacteraemia and periodontal infections are risk markers for cardiovascular disease. (
  • Even though the FDA has not approved specific therapies for vascular cognitive impairment, "detection and control of the traditional risk factors for stroke and cardiovascular disease may be effective in the prevention of vascular cognitive impairment," according to the statement. (
  • Criqui MH, Ninomiya JK, Wingard DL, Ji M, Fronek A. Progression of peripheral arterial disease predicts cardiovascular disease morbidity and mortality. (
  • The completion of this study will assess whether the inhibition of mitochondrial fission, a crucial step in the initiation of cardiovascular disease, can be a new strategy to protect against the development of vascular disease in diabetic patients," Zou said. (
  • The National Vascular Disease Prevention Alliance (NVDPA) is a group of four leading health organisations who are working together to reduce the burden of cardiovascular disease in Australia. (
  • The alliance actively advocates a health system that supports an 'absolute risk' approach to predicting risk of cardiovascular disease, and has produced guidelines for health professionals to use an Integrated Health Check and management in their everyday practice to better detect kidney disease. (
  • Patients suffering from chronic renal disease frequently die from cardiovascular complications. (
  • A damaged and poorly functioning vascular system is the reason for such complications. (
  • In a retrospective study (2004-2009) evaluating data from 12,379 patients (41% women) in 16 centers participating in the Blue Cross Blue Shield of Michigan Cardiovascular Consortium PVI registry who underwent these procedures, female sex was associated with a higher rate of vascular complications, transfusions, and embolism, but no differences wer eseen for inpatient mortality, myocardial infarction (MI), or stroke or transient ischemic attack. (
  • What is the risk of complications in peripheral vascular disease (PVD)? (
  • At the UPMC Heart and Vascular Institute , our vascular surgeons are experts in treating diabetic arterial disease and its complications. (
  • The book addresses open and endovascular interventions in different vascular beds, as well as preoperative workup and optimization, anesthetic considerations, all aspects and expectations of the postoperative care and recovery and is the only book to include specialize in the intricacies of the care of the geriatric patients, the challenging recovery and neurocognitive changes, and ethical considerations for the end stage geriatric patient or in the setting of postoperative complications. (
  • Diabetes can cause serious health complications, including heart disease, blindness, kidney failure and lower-extremity amputations, according to the Centers for Disease Control and Prevention. (
  • Learning about your disease and taking an active role in your disease management will help you feel better and help reduce your chance of developing complications. (
  • If your patient has had surgery for peripheral vascular disease, check his leg for color, temperature, sensation, movement, and pulses during the immediate postoperative period. (
  • The need for emergency surgery can be assessed in the patient with possible total vascular occlusion. (
  • Chronic disease with pulmonary embolism is far less common, but is also often undiagnosed though potentially curable with surgery or other interventions. (
  • The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units). (
  • Carlos Bechara, MD, FACS, and the other vascular specialists at Loyola are recognized leaders in endovascular therapy and vascular surgery. (
  • Learn more about PAD and other potentially life-threatening vascular conditions such as abdominal aortic aneurysm (AAA) - as well as the latest treatment options available. (
  • The odds were 8.7% lower for abdominal aortic aneurysm, 8% lower for cerebrovascular disease, and 19% lower for peripheral arterial disease. (
  • abdominal aortic aneurysm , carotid artery disease , and peripheral arterial disease . (
  • How Is Peripheral Arterial Disease Treated? (
  • CardioSmart/American College of Cardiology: "Peripheral Arterial Disease. (
  • The current worldwide trend in the treatment of peripheral arterial disease (PAD) is towards an increase in endovascular procedures either in the aorto-iliac area or in the infrainguinal district. (
  • Peripheral vascular disease is also called peripheral arterial disease. (
  • Female sex appears to have an effect on outcomes after lower-extremity interventions for peripheral arterial disease (PAD). (
  • Current therapies and investigational drugs for peripheral arterial disease. (
  • Impact of sex on morbidity and mortality rates after lower extremity interventions for peripheral arterial disease: observations from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium. (
  • There is little doubt that one of the greatest advances in the field of peripheral arterial disease was our ability to visualize problems wherever they occurred. (
  • A high-score Mediterranean dietary pattern is associated with a reduced risk of peripheral arterial disease in Italian patients with Type 2 diabetes. (
  • Amino acids stimulate leg muscle protein synthesis in peripheral arterial disease. (
  • Combined supplementation with vitamin C and vitamin E may be of clinical benefit in improving the cutaneous microcirculation by reducing oxidative stress in patients with peripheral arterial disease. (
  • Higher consumption of folate may contribute to the prevention of peripheral arterial disease. (
  • Higher consumption of specific nutrients, including antioxidants (vitamin A, C, and E), vitamin B(6), fiber, folate, and omega-3 fatty acids have a significant protective effect against peripheral arterial disease. (
  • Nonetheless, specific markers for vascular dementia are emerging, including carotid intima-medial thickness and arterial stiffness. (
  • Alviar C, et al "Association of marital status with vascular disease in different arterial territories: a population-based study of over 3.5 million subjects" ACC 2014. (
  • The ABI is used to determine the presence or absence of peripheral arterial disease. (
  • Circulating blood markers and functional impairment in peripheral arterial disease. (
  • Physical activity during daily life and circulating biomarker levels in patients with peripheral arterial disease. (
  • Napoli A, Anzidei M, Zaccagna F, Cavallo Marincola B, Zini C, Brachetti G. Peripheral arterial occlusive disease: diagnostic performance and effect on therapeutic management of 64-section CT angiography. (
  • La arteria pulmonar (izquierda) muestra hipertrofia medial, así como fibroelastosis de la capa íntima en el comienzo de la rama arterial. (
  • Pulmonary hypertension in patients with liver disease or portal hypertension can be due to multiple mechanisms, including hyperdynamic (high-flow) state, increased pulmonary venous congestion (pulmonary venous hypertension), and vascular constriction or obstruction of the pulmonary arterial bed. (
  • Vascular obstruction to pulmonary arterial flow, reflected by increased pulmonary vascular resistance, is an important parameter that defines POPH. (
  • People with diabetes face special health challenges, including an increased risk for cardiovascular conditions such as diabetic arterial or diabetic vascular disease. (
  • These factors can also worsen diabetic arterial disease that already exists. (
  • Why choose UPMC for diabetic arterial disease care? (
  • Vascular surgeons at the UPMC Heart and Vascular Institute treat more than 1,000 people with diabetic arterial disease each year. (
  • or =40 years and with stroke, AMI, or peripheral arterial disease (PAD) were identified from administrative data of United Healthcare plans during 1995-1998. (
  • Take our quiz on peripheral arterial disease (PAD) after you read about the condition ! (
  • While refining ways to grow arterial endothelial cells in the lab, a regenerative biology team at the Morgridge Institute for Research at the University of Wisconsin-Madison unexpectedly unearthed a powerful new model for studying a hallmark of vascular disease. (
  • Peripheral vascular disease (PVD) , also referred to as peripheral arterial disease (PAD), is a serious condition that impacts the blood supply to the legs and feet. (
  • Among predominantly male patients at a Veterans Affairs medical center, the skin disease was associated with a greater likelihood of ischemic heart disease, cerebrovascular disease, and peripheral arterial disease, as well as death, according to Robert Kirsner, M.D., Ph.D., of the University of Miami, and colleagues. (
  • He is an active clinical consultant in all aspects of vascular medicine, including peripheral arterial disease, venous thromboembolic disease, aneurysmal diseases, and all diagnostic strategies in vascular medicine. (
  • How common is peripheral arterial disease? (
  • Boston, MA -- ( SBWIRE ) -- 04/11/2014 -- Global Markets Direct's, 'Peripheral Arterial Disease (PAD)/ Peripheral Vascular Disease (PVD) - Pipeline Review, H1 2014', provides an overview of the Peripheral Arterial Disease (PAD)/ Peripheral Vascular Disease (PVD)'s therapeutic pipeline. (
  • This report provides comprehensive information on the therapeutic development for Peripheral Arterial Disease (PAD)/ Peripheral Vascular Disease (PVD), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. (
  • It also reviews key players involved in the therapeutic development for Peripheral Arterial Disease (PAD)/ Peripheral Vascular Disease (PVD) and special features on late-stage and discontinued projects. (
  • The omega-3 fatty acid docosapentaenoic acid (DPA) reduces the risk of peripheral arterial disease associated with smoking. (
  • Peripheral Arterial Disease (P.A.D. (
  • This article will provide information on Peripheral Arterial Disease (P.A.D.) and provide links to helpful information on screening for the disease. (
  • During a screening procedure for carotid artery disease , patients are asked to lie flat on their back on the exam table. (
  • Carotid Artery Disease: Common Questions and Answers with Drs. Kirksey, Campbell and Smolock. (
  • People who developed these disorders were previously said to have "connective tissue" or "collagen vascular" disease. (
  • These are called undifferentiated systemic rheumatic (connective tissue) diseases or overlap syndromes. (
  • Collagen vascular disease" is the name of a group of diseases that affect your connective tissue. (
  • Collagen vascular disease is sometimes also called connective tissue disease. (
  • However, corticosteroid and immunosuppressant medications commonly treat many connective tissue diseases. (
  • The underlying conditions to secondary vasculitis are infectious diseases, connective tissue disorders, or hypersensitivity disorders. (
  • Any of a group of inflammatory, often autoimmune diseases affecting connective tissue, including lupus erythematosus, rheumatoid arthritis, and scleroderma. (
  • These conditions may include blood clots in the lungs, congenital heart disease, heart and lung diseases which cause low oxygen levels, connective tissue or rheumatologic diseases, sleep apnea, liver disease, HIV infection and exposure to drugs such as amphetamines and diet pills. (
  • What are the symptoms of vascular diseases? (
  • The symptoms for each disease are different. (
  • All the symptoms and consequences of peripheral vascular disease are related to restricted blood flow. (
  • As the disease becomes worse, symptoms occur even during light exertion and, eventually, occur all the time, even at rest. (
  • Symptoms vary according to the specific disease. (
  • Each type of collagen vascular disease has its own set of symptoms. (
  • However, most forms of collagen vascular disease do share some of the same general symptoms. (
  • Lupus is a collagen vascular disease that causes unique symptoms in each patient. (
  • The most common symptoms of Buerger's disease are rest pain, skin ulcerations and gangrene of the fingers and toes. (
  • The symptoms of Buerger's disease can resemble those of other diseases and a thorough evaluation by a physician is needed to determine their true cause. (
  • Superficial vein inflammation and symptoms of Raynaud's occur commonly in patients with Buerger's Disease. (
  • The progressive deprivation of oxygen rich blood to the lower extremities results in the symptoms of this disease. (
  • Pulmonary Hypertension is a complex disease that requires daily self-management, making healthy choices, monitoring your symptoms, and taking medications as prescribed. (
  • Unfortunately, the disease often goes undiagnosed because many people do not experience symptoms in the early stages of PAD or they mistakenly think the symptoms are a normal part of aging. (
  • For example, people who have a kind of functional peripheral vascular disease called Raynaud's disease notice their fingers and toes turn white and sting with pain when they get cold. (
  • Mayo Clinic: "Raynaud's disease. (
  • Vascular disorders include peripheral artery disease (PAD), aneurysms, renal artery disease, peripheral venous disease, varicose veins and venous blood clots as well as Raynaud's disease, Buerger's disease and other specific conditions. (
  • Besides recorded clinical disease, subclinical involvement is significantly increased compared to healthy individuals, reaching 30% in reported studies [ 11 ]. (
  • In general, primary vasculitides are systemic diseases with variable clinical manifestations making it difficult to classify. (
  • Conclusions: There is extensive and increasing evidence that a range of retinal vascular signs and disease are closely linked to CeVD, including subclinical and clinical CeVD. (
  • Both Alzheimer's disease and vascular cognitive impairment share clinical and imaging features, and they may coexist, especially in later life, according to the statement published online July 21. (
  • The authors define vascular cognitive impairment as "a syndrome in which there is evidence of stroke or subclinical vascular brain injury based on clinical or neuroradiological features and that is linked to impairment in at least one cognitive domain. (
  • However, "large prospective clinical trials are needed to identify vascular biomarkers, prevention strategies, and both pharmacologic and nonpharmacologic treatments, Grysiewicz wrote. (
  • The resolution of vascular inflammation is an important driver of vessel wall remodeling and functional recovery in these clinical settings. (
  • Further investigations are needed to understand the molecular and cellular mechanisms of resolution in the vasculature, to improve tools for clinical measurement, and to better define the potential for "resolution therapeutics" in vascular patients. (
  • Environmental Conditions The examinations will be carried out in a designated temperature controlled clinical room in the Vascular Lab at Hull Royal Infirmary. (
  • It covers emerging therapies for Peripheral Vascular Disease in active clinical development stages including early and late stage clinical trials. (
  • The report provides Peripheral Vascular Disease pipeline products by clinical trial stages including both early and late stage development - phase 3 clinical trials, phase 2 clinical trials, phase 1 clinical trials, preclinical research, and discovery stage. (
  • There are many vascular conditions that require clinical care by a physician or other health care professional. (
  • 2016 AHA/ACC Guideline on the management of patients with lower extremity peripheral artery disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. (
  • Here, we welcome the latest research advances focusing on "Drug Development and Target Discovery in Pulmonary Vascular Diseases", including the discovery of new candidate compounds targeting pulmonary vascular diseases in basic and clinical pharmacology, as well as active components in traditional pharmaceutical ingredients using high-throughput screening strategies, high-content screening strategies, and virtual molecular docking techniques. (
  • Approach and Results- Growing evidence from preclinical and clinical studies has implicated alterations in hypoxia-inducible factor 1 levels in the abrogation of proangiogenic pathways, including vascular endothelial growth factor A/phosphoinositide 3′ kinase/AKT/endothelial nitric oxide synthase and in the activation of antiangiogenic signals characterized by accumulation of advanced glycation end products, reactive oxygen species overproduction, and endoplasmic reticulum stress. (
  • They said the findings have "tremendous and far-reaching clinical implications, as all of these vascular conditions represent a major financial cost to the healthcare system, as well as a major cause of disability and death. (
  • He currently is an associate Clinical Professor of Internal Medicine and director of The Vascular Technology training program at UMDNJ, Newark NJ and Director of Vascular Outreach and attending in Cardiovascular Medicine at Gagnon Heart and Vascular Institute, Morristown, NJ. (
  • Chronic kidney disease (CKD) is a clinical model of premature ageing characterized by progressive vascular disease, systemic inflammation, muscle wasting and frailty. (
  • Therefore, another function of Current Vascular Pharmacology is to bridge the gap between clinical practice and ongoing research. (
  • The latest report from Fore Pharma, Peripheral Vascular Disease Pipeline Highlights - 2017, provides most up-to-date information on key pipeline products in the global Peripheral Vascular Disease market. (
  • Point out that clinicians are encouraged to use screening tools to detect cognitive impairment in their older patients and to continue to treat vascular risks according to nationally or regionally accepted guidelines for the management of hypertension, diabetes, and hypercholesterolemia. (
  • The pulmonary hypertension service cares for a sizeable and rapidly growing population of patients with pulmonary vascular disease. (
  • This change in identity, known as the endothelial to mesenchymal transition, is widely recognized as a major risk factor for congenital heart disease, fibrosis of vital organs, hypertension and heart attacks. (
  • Pulmonary vascular disease includes a spectrum of conditions or diseases in which the most serious and common complication is pulmonary hypertension. (
  • While pulmonary hypertension can occur without any obvious relationship to other diseases ('primary pulmonary hypertension') the majority of cases of pulmonary hypertension are seen in association with a variety of medical conditions and/or toxic exposures. (
  • If you have a collagen vascular disease, your immune system causes inflammation in your collagen and nearby joints. (
  • Inflammation of the human vasculature is a manifestation of many different diseases ranging from systemic autoimmune diseases to chronic inflammatory diseases, in which multiple types of immune cells are involved. (
  • In this review, we focus on the CD4 + T cells in the context of vascular inflammation and describe the evidence supporting the role of different T cell subsets in vascular inflammation. (
  • Selective targeting of pathogenic T EM cells might enable a more tailored therapeutic approach that avoids unwanted adverse side effects of generalized immunosuppression by modulating the effector functions of T cell responses to inhibit the development of vascular inflammation. (
  • Vasculitides comprises a group of rare diseases, characterized by inflammation of the blood vessel walls. (
  • The identification of their potent effects in classic animal models of sterile inflammation triggered interest in their vascular properties. (
  • And there might be biological explanations, as well, he said, noting that prior research has shown that married people have lower levels of vascular inflammation. (
  • Conditions contributing to varicose veins include genetics, obesity, pregnancy, hormonal changes at menopause, work or hobbies requiring extended standing, and past vein diseases such as thrombophlebitis, an inflammation of a vein as a blood clot forms. (
  • Recent human and animal studies suggest that activation of the mineralocorticoid receptor (MR) by aldosterone, the final product of the renin-angiotensin-aldosterone system, causes microvascular damage, vascular inflammation, and endothelial dysfunction. (
  • Buerger's disease occurs almost exclusively in heavy tobacco users, including those who smoke cigarettes or chew tobacco. (
  • There is only one treatment for Buerger's disease - immediate and complete cessation of smoking and other tobacco use. (
  • Another rarer form of peripheral vascular disease, known as Buerger's disease can be referenced separately. (
  • Non-invasive or invasive vascular diagnostic tools (e.g. (
  • Optimum utilization of modern vascular diagnostic technology requires expert users. (
  • Loyola provides a wide range of services including advanced diagnostic tools , initial screenings , endovascular interventions and genetic counseling for patients at risk for heart and vascular disease. (
  • Potentially fatal diseases include vascular diseases, diseases of the cardiac valves, and metabolic disorders, many of which can only be identified or ruled out histopathologically. (
  • In a class of diseases known as autoimmune disorders , the body's immune system attacks its own tissues. (
  • Pulmonary vascular disease is a broad category of disorders caused by abnormal blood flow between the heart and the lungs, which is threatening millions of people around the world. (
  • Early identification of peripheral vascular disease allows interventions to be given and might improve outcomes," they write in The Lancet . (
  • This book presents a comprehensive and state-of the-art approach to vascular disease for the geriatric patient, focusing on vascular pathology and interventions but also on perioperative care, anesthetic care, functional outcomes and quality of life, as well as ethical considerations that impact decision making. (
  • Our mission is to build healthier lives, free of cardiovascular diseases and stroke. (
  • The rate of dementia in those older than 65 in developed countries can be as high as 10%, and while the prevalence of Alzheimer's disease doubles every 4.3 years, the prevalence of vascular dementia doubles every 5.3 years, according to a scientific statement from the American Heart Association/American Stroke Association. (
  • Risk markers for vascular cognitive impairment also can be similar to those for stroke. (
  • The various names attributed to vascular-related cognitive decline have included multi-infarct dementia, vascular dementia, and post-stroke dementia, said Rebbeca Grysiewicz, DO, from the University of Illinois at Chicago, in an invited commentary. (
  • Heart diseases are the number one cause of death and sickness for Canadians, and with approximately 80,000 individuals affected yearly, the cost of diagnosing, treating and coping with heart disease and stroke annually exceeds $16 billion. (
  • People with diabetes are more likely to have a heart attack or stroke, or experience kidney disease. (
  • Peripheral vascular disease, which is difficult to detect, is a risk factor for heart disease, stroke and death. (
  • The researchers reviewed 28 studies assessing the link between differences in systolic blood pressure between the left and right arms and heart, stroke and vascular disease and death. (
  • We estimated the occurrence of secondary stroke, acute myocardial infarction (AMI), and vascular deaths among 2 large, managed care samples. (
  • Cumulative occurrences of subsequent stroke, AMI, or vascular death were estimated by survival analysis. (
  • If you have PAD, you are also at higher risk for heart disease and stroke. (
  • Many of the same specialties make up Loyola's stroke team, caring for patients whose vascular disease has caused an interruption in the blood supply to the brain-resulting in a stroke, which is a medical emergency. (
  • In this context, vasculopathy can be directly aetiologically implicated in the pathogenesis of the disease, presenting as an acute/subacute manifestation of lupus (e.g., antiphospholipid syndrome, lupus vasculitis). (
  • however, in settings such as acute limb ischemia, this latent disease can suddenly become life-threatening and necessitate emergency intervention to minimize morbidity and mortality. (
  • Vascular disease may manifest acutely when thrombi, emboli, or acute trauma compromises perfusion. (
  • BACKGROUND AND PURPOSE: Few data exist for large managed care populations on the occurrence of subsequent acute ischemic events in persons with established atherosclerotic vascular disease. (
  • The SUDDEN onset of severe leg pain without provocation, a cold foot, mottling or bluish discoloration to the foot, and absence of pulses indicates an acute vascular occlusion of the diseased artery, requiring IMMEDIATE emergency evaluation and treatment. (
  • It follows that considerable research is directed at establishing effective treatment for acute vascular events. (
  • To receive news and publication updates for Autoimmune Diseases, enter your email address in the box below. (
  • However, they do have one thing in common: All autoimmune diseases are chronic conditions. (
  • For both autoimmune diseases and chronic inflammatory diseases several observations support a key role for T lymphocytes in these disease pathologies, but the underlying mechanisms are poorly understood. (
  • Previous studies in several autoimmune diseases have demonstrated a significant role for a specific subset of CD4 + T cells termed effector memory T (T EM ) cells. (
  • Exercising, wearing compression hose, elevating and resting the legs will not make the veins go away or keep them from getting worse because the underlying venous reflux disease has not been addressed. (
  • Thukkani AK, Kinlay S. Endovascular intervention for peripheral artery disease. (
  • Our board-certified vascular disease team includes imaging specialists, interventional cardiologists, vascular surgeons and endovascular specialists. (
  • The vascular endothelial growth factor (VEGF) family of growth factors controls pathological angiogenesis and increased vascular permeability in important eye diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD). (
  • When we focus on the VEGF receptors, recent findings suggest a role of VEGFR-1 as a functional receptor for placenta growth factor (PlGF) and vascular endothelial growth factor-A (VEGF)-A in pericytes and vascular smooth muscle cells in vivo rather than in endothelial cells, and strongly suggest involvement of pericytes in early phases of angiogenesis. (
  • and assimilation of information from areas outside cardiology, ie, vascular surgeons and interventional radiologists into a reader-friendly format geared toward the average practicing internist or cardiologist. (
  • Our comprehensive, team-based approach includes vascular, orthopaedic, plastic, and general surgeons - as well as podiatry and internal medicine professionals - all working together to provide an effective treatment plan that is right for you. (
  • With its concise yet comprehensive summary of the field, Vascular Disease in Older Adults is the ultimate resource for geriatricians, cardiologists, surgeons, anesthesiologists, and all physicians of who care for the aging patient with vascular disease. (
  • At Loyola Medicine, we bring together vascular specialists like Bernadette Aulivola, MD, and nurses, cardiologists, neurologists, surgeons and radiologists on our care teams to manage vascular diseases in our patients. (
  • Loyola takes a multidisciplinary approach to the care of patients with vascular disease, bringing neurologists, neurosurgeons, radiologists, cardiologists and cardiovascular surgeons together. (
  • How is peripheral vascular disease diagnosed? (
  • Home / Health & Wellness / Videos / How is Peripheral Vascular Disease Diagnosed? (
  • Congenital vascular anomalies such as arteriovenous malformations (Osler-Weber-Rendu syndrome) may remain undetected until death. (
  • There are approximately 32,000 cases new cases of congenital heart disease per year in the United States and 1.5 million new cases worldwide. (
  • Pacific Heart Lung & Blood Institute: "All About Vascular Disease. (
  • American Heart Association: "What Is Peripheral Vascular Disease? (
  • Vascular disease is defined as any condition that affects the circulatory system - the vessels that carry the blood to and from the heart. (
  • Prior studies have identified associations between marriage and risks of heart disease -- including a recent one showing that middle-age women who lived with a spouse or partner had a lower risk of dying from ischemic heart disease . (
  • All vascular screening tests done at the UPMC Heart and Vascular Institute are performed by registered vascular technologists under the direction of the vascular surgeon. (
  • Please browse these pages for information on common diseases, conditions and concerns affiliated with heart disease. (
  • Long-term cardiovascular outcomes following ischemic heart disease in patients with and without peripheral vascular disease. (
  • UC San Diego Health specialists regularly perform balloon angioplasty, atherectomy (removing plaque from a blood vessel) and stenting (inserting a mesh tube into a blood vessel) to treat vascular disease and prevent heart attacks and strokes. (
  • People with diabetes are at much greater risk for heart and vascular disease compared to people who do not have diabetes. (
  • For an appointment with a vascular specialist at the UPMC Heart and Vascular Institute, complete an appointment request form or call 1-855-UPMC-HVI (876-2484). (
  • Recent findings suggest a novel approach for protecting people with diabetes from their higher risk of advanced blood vessel disease, which sets the stage for early heart attacks and strokes. (
  • Flu Shots Protect Hearts, Too Many people with heart disease and other chronic health conditions die from the flu each year. (
  • Improving heart health just got a little bit simpler, thanks to the ABC's of heart disease prevention. (
  • The Miller Family Heart & Vascular Institute has created a series of online presentations to provide you with information about heart, vascular, and thoracic conditions and treatments. (
  • Explore our free online video presentations for information about heart, vascular and thoracic conditions and treatments. (
  • These cells, which have been notoriously difficult to grow in stable quantities, are essential to any future tissue engineering efforts to combat heart disease. (
  • When it comes to diagnosing vascular disease and treating vascular disease , Hoag Heart & Vascular Institute is a nationally recognized leader. (
  • He is a Past-President of the Society for Vascular Medicine and Biology, and received the first designation as Master of the Society for Vascular Medicine.Dr. Jaff is a Fellow of the American College of Physicians, American College of Cardiology, and American Heart Association. (
  • People with a family history of heart or vascular disease. (
  • The results are drastic, as Marsche outlines: "While, prior to this modification, HDL helped to prevent vascular constriction, this protective effect is dramatically reduced by carbamylation. (
  • I may begin with the unequivocal statement that neither my associates nor I have any magic formula which predictably will prevent vascular disease in the diabetic. (
  • A unique system that uses a balloon and sound waves to break up plaque in patients with peripheral artery disease has just been cleared by the FDA. (
  • This results in a wider lumen and should lead to improved outcomes for patients with peripheral artery disease for whom an extra millimeter or two of increased space for blood to flow can make a whole lot of difference. (
  • The benefits of kidney transplantation in diabetic patients with peripheral vascular disease (PVD) are unclear. (
  • Vascular diseases are conditions which affect your vascular system. (
  • At Johns Hopkins, we commit to continuously advancing radiological services for vascular conditions. (
  • Dementia itself is not a disease, but a syndrome caused by other conditions. (
  • Learn about different types of liver conditions and treatment options, and how to live healthy when you have liver disease. (
  • A multidisciplinary team of Mayo Clinic specialists cares for patients with chronic liver disease, which occurs most commonly secondary to cirrhosis, including pulmonologists with expertise in the management of lung conditions commonly encountered in this population. (
  • Our top priority is to educate our patients about the dangers of peripheral vascular disease and other vascular conditions. (
  • Modified "good" cholesterol (HDL) and the activation of specific genes are causes of damage to the vascular system in chronic renal disease . (
  • We were able to identify two previously unknown mechanisms in human tissue and in an animal model by which cyanate can lead to a dysfunctional vascular system in patients with chronic renal disease", explains Gunther Marsche. (
  • This is an effect that can occur particularly in patients with chronic renal disease. (
  • however, a variable but measurable amount of AD pathologic changes exist in most cognitively intact elderly individuals who undergo autopsy, indicating that AD is a chronic disease with latent and prodromal stages and suggesting that individuals may have varying abilities to compensate, either biologically or functionally, for the presence of AD. (
  • Early Vascular Ageing and Cellular Senescence in Chronic Kidney Disease. (
  • Triggers, effector pathways and features of senescence in tissue dysfunction, ageing and chronic diseases. (
  • Peripheral vascular disease with occlusion of the major vessels below the knee was diagnosed and the patient was scheduled for left femoral popliteal bypass graft. (
  • 10 These grafts were also developed for bypassing areas of occlusion, both in the aortoiliac area and for femoral-popliteal occlusive disease. (
  • The untreated vascular occlusion can result in gangrene (tissue death due to inadequate blood supply) of the extremity below the occusion. (
  • Peripheral vascular disease is a progressive disease that can lead to gangrene of the affected area. (
  • At the most severe stage of the disease, when the blood flow is greatly restricted, gangrene can develop in those areas lacking blood supply. (
  • A 71-year-old woman with a history of insulin dependent diabetes mellitus and severe peripheral vascular disease was admitted with gangrene of the left big toe. (
  • Severe untreated peripheral vascular disease can result in gangrene, or tissue death due to an inadequate blood supply. (
  • In order to achieve precise drug development and precise drug therapy, the action and mechanisms of drugs and drug interactions within the body need to be fully elucidated from different perspectives and dimensions in pulmonary vascular biology. (
  • The purpose of this review is to develop new insights into the cell biology of VEGFs and vascular cells in angiogenesis and vascular leakage in general, and to provide the rationale and possible pitfalls of inhibition of VEGFs as a therapy for ocular disease. (
  • The vascular manifestations associated with diabetes mellitus (DM) result from the dysfunction of several vascular physiology components mainly involving the endothelium, vascular smooth muscle and platelets. (
  • In the second case, cyanate activates a gene that can amplify inflammatory responses in the vascular system. (
  • Is the Subject Area "Inflammatory bowel disease" applicable to this article? (
  • The risk factors for vascular diseases can vary, depending on the specific disease. (
  • A higher number of risk factors for vascular disease in midlife could raise the risk of dementia, researchers suggest. (
  • With the help of positron emission tomography (PET) brain imaging, Dr. Gottesman and team sought to gain a better understanding of how risk factors for vascular disease might affect beta-amyloid accumulation in the brain. (
  • Compared with participants who had no risk factors for vascular disease at study baseline, those who had two or more risk factors were found to have significantly higher levels of beta-amyloid in their brains. (
  • G46 - Vascular syndromes of brain in cerebrovascular diseases is a topic covered in the ICD-10-CM . (
  • ICD-10 , (
  • Collagen vascular diseases can be heritable (inherited from one's parents) or autoimmune (resulting from activity of the body's immune system against itself). (
  • This article deals with autoimmune forms of collagen vascular diseases. (
  • Collagen vascular disease is an autoimmune disease . (
  • Several collagen vascular diseases, including lupus, scleroderma, and rheumatoid arthritis, are more common in women than in men. (
  • Temporal arteritis, or giant cell arteritis, is another form of collagen vascular disease. (
  • The treatment for collagen vascular disease varies according to your individual condition. (
  • Physical therapy or gentle exercise can also treat collagen vascular disease. (
  • The outlook for collagen vascular disease varies from person to person, and it depends on their specific disease. (
  • We also discuss the pathophysiology of vascular disease associated with DM. (
  • Cardiovascular mortality increases during epidemics, and about a third of all such patients have had an infectious diseases immediately before the vascular attack. (
  • Statistically, the onset of this vascular disease in the diabetic is earlier and the progress more rapid. (
  • Hospital Readmissions in Diabetic Kidney Transplant Recipients with Peripheral Vascular Disease. (
  • ATLANTA -- Dr. Ming-Hui Zou, director of the Center for Molecular & Translational Medicine and a Georgia Research Alliance Eminent Scholar in Molecular Medicine, has renewed a four-year, $2.3 million federal grant to study the role of an enzyme in causing diabetic vascular diseases and the molecular mechanism that leads to these diseases. (
  • The findings could lead to a new treatment for diabetic vascular diseases. (
  • Which treatment you get depends on which vascular disease you have and how severe it is. (
  • Effect of long-term mesoglycan treatment on fibrinogen plasma levels in patients with ischemic cerebrovascular disease," Current Therapeutic Research , vol. 52, no. 5, pp. 666-670, 1992. (
  • Open trial of mesoglycan in the treatment of cerebrovascular ischemic disease," Acta Neurologica , vol. 43, no. 2, pp. 108-112, 1988. (
  • It is very unlikely that a short treatment with a single antibiotic should be able to prevent repeated vascular attacks. (
  • Treatment of periodontal disease result in imporvements in endothelial dysfuncton and reduction of the carotid intima-media thickness. (
  • The complexity of vascular cognitive impairment can make identification challenging, but the implementation of a standard language allows for more consistent investigation into the neuropathophysiology, risk factors, prevention, treatment options, and research initiatives," Grysiewicz wrote. (
  • The clinics provide initial evaluation, education and continuing treatment of patients with pulmonary vascular disease. (
  • Nanoscale strategies: treatment for peripheral vascular disease and critical limb ischemia. (
  • Currently, the United Network for Organ Sharing (UNOS) has approved automatic higher priority for LT (exception points via the Model for End Stage Liver Disease, or MELD) if treatment can improve pulmonary hemodynamics (reduce mean pulmonary artery pressure to less than 35 mm Hg). (
  • This is a new pathway for the study and treatment of Alzheimer's disease," said Zlokovic. (
  • Researchers at The University of Texas Health Science Center at Houston (UTHealth) Medical School have developed a non-surgical preventative treatment for peripheral vascular disease, a circulatory problem of the legs, which has been tested in a mouse model of the disease, a new study published in the journal Cell Reports reveals. (
  • Lithoplasty represents a new mechanism of treatment and is revolutionary for the care of patients with calcified peripheral vascular disease, a difficult-to-treat patient population," in a statement said Kenneth Rosenfield, M.D., Section Head for Vascular Medicine and Intervention at Massachusetts General Hospital. (
  • Current Vascular Pharmacology will publish reviews to update all those concerned with the treatment of vascular disease. (
  • The best treatment for PAD depends on a number of factors, including your overall health and the seriousness of the disease. (
  • Peripheral vascular disease may also occur suddenly if an embolism occurs or when a blot clot rapidly develops in a blood vessel already restricted by an atherosclerotic plaque, and the blood flow is quickly cut off. (
  • Atherosclerotic disease has been detected in lupus patients from cohort studies in a significant proportion of the population (≥30%), even when corrected for all other comorbidities [ 3 , 14 ]. (
  • CONCLUSIONS: Among these managed care enrollees with existing atherosclerotic vascular disease, subsequent ischemic events represent a significant symptomatic disease burden. (
  • Vascular Disease includes any condition that affects your circulatory system, such as peripheral artery disease. (