Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
Phenolic metacyclophanes derived from condensation of PHENOLS and ALDEHYDES. The name derives from the vase-like molecular structures. A bracketed [n] indicates the number of aromatic rings.
Polymers where the main polymer chain comprises recurring amide groups. These compounds are generally formed from combinations of diamines, diacids, and amino acids and yield fibers, sheeting, or extruded forms used in textiles, gels, filters, sutures, contact lenses, and other biomaterials.
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Oligopeptide antibiotics from Streptomyces distallicus. Their binding to DNA inhibits synthesis of nucleic acids.
Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.
A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.
A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
6-carbon straight-chain or branched ketones.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole. Antifungal antibiotic isolated from Pseudomonas pyrrocinia. It is effective mainly against Trichophyton, Microsporium, Epidermophyton, and Penicillium.
Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.
Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)
A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Linear TETRAPYRROLES that give a characteristic color to BILE including: BILIRUBIN; BILIVERDIN; and bilicyanin.
A republic consisting of a group of about 100 islands and islets in the western Pacific Ocean. Its capital is Koror. Under Spain it was administered as a part of the Caroline Islands but was sold to Germany in 1899. Seized by Japan in 1914, it was taken by the Allies in World War II in 1944. In 1947 it became part of the U.S. Trust Territory of the Pacific Islands, became internally self-governing in 1980, obtained independent control over its foreign policy (except defense) in 1986, and achieved total independence October 1, 1994. (Webster's New Geographical Dictionary, 1988, p915; telephone communication with Randy Flynn, Board on Geographic Names, 17 January 1995)
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
A genus of large, brightly colored SPONGES in the family Agelasidae, possessing a skeleton of spongin fibers with a core of large spicules (megascleres).
That portion of the electromagnetic spectrum from the UHF (ultrahigh frequency) radio waves and extending into the INFRARED RAYS frequencies.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Inorganic or organic compounds derived from phosphine (PH3) by the replacement of H atoms. (From Grant & Hackh's Chemical Dictionary, 5th ed)
1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone. Biosynthesized from hemoglobin as a precursor of bilirubin. Occurs in the bile of AMPHIBIANS and of birds, but not in normal human bile or serum.
The characteristic three-dimensional shape of a molecule.
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.
An antineoplastic agent derived from BLEOMYCIN.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
Inorganic salts of the hypothetical acid, H3Fe(CN)6.
Organic compounds containing a carbonyl group in the form -CHO.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.
Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.
The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck's constant and v is the frequency of the radiation.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.
The phylum of sponges which are sessile, suspension-feeding, multicellular animals that utilize flagellated cells called choanocytes to circulate water. Most are hermaphroditic. They are probably an early evolutionary side branch that gave rise to no other group of animals. Except for about 150 freshwater species, sponges are marine animals. They are a source of ALKALOIDS; STEROLS; and other complex molecules useful in medicine and biological research.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.
Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
The measurement of the quantity of heat involved in various processes, such as chemical reactions, changes of state, and formations of solutions, or in the determination of the heat capacities of substances. The fundamental unit of measurement is the joule or the calorie (4.184 joules). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
PYRROLE disorder, suffered by 10- per cent of the population, is a condition with many physical and psychological symptoms, yet ... She diagnosed pyrrole disorder. Unusually, I had heard of pyrrole, as a friends son had it. Its a genetic blood disorder that ... Could you have Pyrrole disorder?. PYRROLE disorder, suffered by 10- per cent of the population, is a condition with many ... "Pyrrole disorder is quite common - almost a third of patients I see have it - but not many doctors know about it. It is a ...
Other names: 1H-Pyrrole; Azole; Divinylenimine; Imidole; Monopyrrole; Pyrrol; 1-Aza-2,4-cyclopentadiene; Divinyleneimine; ... Helm, R.V.; Lanum, W.J.; Cook, G.L.; Ball, J.S., Purification and Properties of Pyrrole, Pyrrolidine, Pyridine and 2- ... Gapeev, A.; Yang, C.-N., Binding Energies of Gas-Phase Ions with Pyrrole. Experimental and Quantum Chemical Results, J. Phys. ... Kimizuka, Wieslawa; Szydlowski, Jerzy, Vapor pressure isotope effect of n-deuterated pyrrole, Fluid Phase Equilibria, 1992, 77 ...
Other names: 1H-Pyrrole; Azole; Divinylenimine; Imidole; Monopyrrole; Pyrrol; 1-Aza-2,4-cyclopentadiene; Divinyleneimine; ...
Pyrrole definition, a colorless, toxic, liquid, five-membered ring compound, C4H5N, that is a component of chlorophyll, hemin, ... OTHER WORDS FROM pyrrole. pyr·rol·ic [pi-rol-ik, -roh-lik], /pɪˈrɒl ɪk, -ˈroʊ lɪk/, adjective ... Derived forms of pyrrole. pyrrolic (pɪˈrɒlɪk), adjective. Word Origin for pyrrole. C19: from Greek purrhos red, from pur fire ... pyrrole. in a sentence. *. This brings selenophene more akin to pyrrole than thiophene, but the group -NH- in the molecule of ...
Pyrrole aus Azinen" [Synthesis of pyrrole derivatives: pyrrole from diethyl succinyl succinate, pyrrole from azines]. Berichte ... In contrast, substituted pyrroles (including protected pyrroles) have been used in a broad range of transformations. Pyrroles ... Pyrrole aldehydes can be formed by a Vilsmeier-Haack reaction. N-Acylation of simple pyrrole does not occur.[citation needed] ... Pyrrole has a nutty odor. Pyrrole is a 5-membered aromatic heterocycle, like furan and thiophene. Unlike furan and thiophene, ...
Pyrrole disorder is a clinical condition that causes dramatic shifts in mood. It sometimes occurs alongside other mental health ... What causes pyrrole disorder?. The exact cause of pyrrole disorder is unknown, but its thought to be a hereditary condition ... Pyrrole disorder vs. bipolar disorder. Its not uncommon for people with bipolar disorder to also have excess pyrrole molecules ... Pyrrole disorder develops when there are too many pyrrole molecules in your body. These can strip your system of essential ...
... or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole ... or trisubstituted pyrroles. The value of th ...
Pyrrole-imidazole polyamides (PIPs) are a class of polyamides have the ability to bind to minor grooves found in the DNA helix ... Wu, Chunlei; Wang, Wei; Fang, Lijing; Su, Wu (July 2018). "Programmable pyrrole-imidazole polyamides: A potent tool for DNA ... Kawamoto, Yusuke; Bando, Toshikazu; Sugiyama, Hiroshi (May 2018). "Sequence-specific DNA binding Pyrrole-imidazole polyamides ...
A series of pyrrole and pyrrolopyrimidine derivatives were examined for their ,i,in vivo,/i, antihyperglycemic activity. ... Only the open form pyrrole derivatives, namely, I a, c, and e (pyrrole o-amino carbonitriles), induced a significant decrease ... Regarding the side chain function, for the pyrroles derivatives, the free amino group in pyrrole o-amino carbonitriles I a, c, ... The tested compounds were classified into 2 main groups: first, the open form pyrrole derivatives, namely, Ia-e (pyrrole o- ...
... Halyna M. Kuznietsova, Maryna S. Yena, Iryna P. Kotlyar ... "Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate," The Scientific World Journal, vol. 2016, Article ID ...
Pyrrole-2-carboxaldehyde 98%; CAS Number: 1003-29-8; EC Number: 213-705-5; Synonyms: 2-Formylpyrrole; find Sigma-Aldrich-P73404 ... Regiocontrolled synthesis of pyrrole-2-carboxaldehydes and 3-pyrrolin-2-ones from pyrrole Weinreb amides. ... pyrrole Weinreb amides), which were converted into the corresponding pyrrole-2-carboxaldehydes by treatment. ... ... A Barton-Zard pyrrole synthesis between N-methoxy-N-methyl-2-isocyanoacetamide and alpha-nitroalkenes or beta-nitroacetates ...
... pyrrol-1-ylpyridine-3-carboxylic acid
Several medically and agriculturally important natural products contain pyrrole moieties. Precursor labeling studies of some of ... and one of the pyrroles of undecylprodigiosin. This suggests a novel mechanism for pyrrole biosynthesis. The biosynthetic gene ... This establishes a novel mechanism for pyrrole biosynthesis and extends the hypothesis that organisms use A/PCP pairs to ... Several medically and agriculturally important natural products contain pyrrole moieties. Precursor labeling studies of some of ...
Fungicidally active novel 1-aminomethyl-3-aryl-4-cyano-pyrroles of the formula ##STR1## in which Ar represents optionally ... It is furthermore known that certain 3-aryl-pyrroles, such as, for example, 4-cyano-3-(2,3-dichlorophenyl)-pyrrole, likewise ... The 3-aryl-4-cyano-pyrroles of the formula (II) are known (cf., for example, EP No. 174,910, EP No. 182,738 or EP No. 133,247 ... Finally, it has been found that the new 1-aminomethyl-3-aryl-4-cyano-pyrroles of the general formula (I) have a good action ...
Pyrrole-2-carboxylate can serve as the sole source of carbon, nitrogen, and energy for a strain tentatively identified to ... designated as pyrrole-2-carboxylate monooxygenase belongs to the recently discovered new class of two-component flavin aromatic ... Two-component flavin-dependent pyrrole-2-carboxylate monooxygenase from Rhodococcus sp.. Becker D1, Schräder T, Andreesen JR. ... but exhibited a pyrrole-2-carboxylate-dependent oxygen consumption when it was complemented with the reductase component, FAD, ...
Looking for TCI AMERICAS Pyrrole-2-Carboxylic Acid,5g (19UP67)? Graingers got your back. Price:$193.50. Easy ordering & ...
1H-Pyrrole, 1-(triphenylplumbyl)-. Regulatory process names 1 IUPAC names 1 Other identifiers 1 ...
1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2 ... 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2 ... 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2 ... 5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-N,4-diphenyl-2-(propan-2-yl)-1H-pyrrole-3-carboxamide ...
... and N-vinyl-2-trifluoroacetylpyrroles gives pyrrole-2-carboxylic acids and their N-vinyl derivatives in good yields; most of ... Haloform cleavage of 2-trifluoroacetyl- and N-vinyl-2-trifluoroacetylpyrroles gives pyrrole-2-carboxylic acids and their N- ...
Pyrrole Propyl Amine , C7H12N2 , CID 55265879 - structure, chemical names, physical and chemical properties, classification, ...
1-Methyl-1H-pyrrol-3-amine , C5H8N2 , CID 12532405 - structure, chemical names, physical and chemical properties, ...
New pyrrole-based histone deacetylase inhibitors: binding mode, enzyme- and cell-based investigations.. Mai A1, Valente S, ... Through structure-based drug design, two isomers of the APHA lead compound 1, the 3-(2-benzoyl-1-methyl-1H-pyrrol-4-yl)-N- ... hydroxy-2-propenamide 2 and the 3-(2-benzoyl-1-methyl-1H-pyrrol-5-yl)-N-hydroxy-2-propenamide 3 (iso-APHAs) were designed, ...
PYRROLE-2-CARBOXYLATE. C5 H4 N O2. WRHZVMBBRYBTKZ-UHFFFAOYSA-M. Ligand Interaction. ... COMPLEX OF MONOMERIC SARCOSINE OXIDASE WITH THE INHIBITOR PYRROLE-2-CARBOXYLATE. *DOI: 10.2210/pdb1ELI/pdb ...
methyl pyrrole-3-carboxylate, 1h-pyrrole-3-carboxylic acid methyl ester, 1h-pyrrole-3-carboxylic acid, methyl ester, methyl 3- ... methyl pyrrole-3-carboxylate, 1h-pyrrole-3-carboxylic acid methyl ester, 1h-pyrrole-3-carboxylic acid, methyl ester, methyl 3- ... Methyl pyrrole-3-carboxylate is used as an organic chemical synthesis intermediate.. Solubility. Slightly soluble in water.. ... pyrrolecarboxylate, 3-methoxycarbonyl-1h-pyrrole, pubchem22507, acmc-1cmqn, methylpyrrole-3-carboxylate, 4,5-methoxy- ...
pyrrole-2-carboxylic acid, minaline, minalin, 2-pyrrolecarboxylic acid, pyrrole-2-carboxylicacid, pyrrole-2-carboxylate, 2- ... pyrrole-2-carboxylic acid, minaline, minalin, 2-pyrrolecarboxylic acid, pyrrole-2-carboxylicacid, pyrrole-2-carboxylate, 2- ... Pyrrole-2-carboxylic acid has demonstrated antiparasitic activity against Trypanosomes by selective proline racemase inhibition ...
1H-pyrrol-2-yl)methanol; CAS Number: 27472-36-2; find Enamine-ENA413165010 MSDS, related peer-reviewed papers, technical ...
... pyrrole-co- N-methyl pyrrole) (1:1) on indium-tin-oxide (ITO) glass plates. This... ... Cholesterol Pyrrole Cholesterol Oxidase Enzyme Electrode Cyclic Voltammetric Study This is a preview of subscription content, ... Cholesterol oxidase (ChOx) has been electrochemically entrapped onto p-toluene sulphonate (PTS) doped poly (pyrrole-co-N-methyl ... pyrrole) (1:1) on indium-tin-oxide (ITO) glass plates. This ChOx-copolymer-PTS/ITO bioelectrode has been characterized using ...
3. Hydroquinone-pyrrole dyads with varied linkers. Open this publication in new window or tab ,,Hydroquinone-pyrrole dyads with ... A modular organic synthetic approach allows the assembly of the pyrrole and quinone units into quinone-pyrrole dyads. These ... A series of pyrroles functionalized in the 3-position with p-dimethoxybenzene via various linkers (CH2, CH2CH2, CH=CH, C≡C) has ... Quinone-Pyrrole Dyad Based Polymers for Organic Batteries: From Design to Application. Huang, Hao Uppsala University, ...
Pyrrole was first discovered in 1834 and its name comes from the Greek for reddish or fiery ... Pyrrole was first discovered in 1834 and its name comes from the Greek for reddish or fiery ...
  • The Hantzsch pyrrole synthesis is the reaction of β-ketoesters (1) with ammonia (or primary amines) and α-haloketones (2) to give substituted pyrroles (3). (wikipedia.org)
  • The Knorr pyrrole synthesis involves the reaction of an α-amino ketone or an α-amino-β-ketoester with an activated methylene compound. (wikipedia.org)
  • In the Paal-Knorr pyrrole synthesis, a 1,4-dicarbonyl compound reacts with ammonia or a primary amine to form a substituted pyrrole. (wikipedia.org)
  • The starting materials in the Piloty-Robinson pyrrole synthesis, named for Gertrude and Robert Robinson and Oskar Piloty, are two equivalents of an aldehyde and hydrazine. (wikipedia.org)
  • Regiocontrolled synthesis of pyrrole-2-carboxaldehydes and 3-pyrrolin-2-ones from pyrrole Weinreb amides. (sigmaaldrich.com)
  • A regiocontrolled synthesis of 3,4-disubstituted pyrrole-2-carboxaldehydes was completed in two steps from acyclic starting materials. (sigmaaldrich.com)
  • Methyl pyrrole-3-carboxylate is used as an organic chemical synthesis intermediate. (fishersci.ca)
  • Singh, R. N. Eco-friendly synthesis, spectral and computational study of pyrrole-2-carboxaldehyde salicylhydrazone (PCSH) for its application. (alfa.com)
  • A green and practical method for the synthesis of 3-pyrrole-substituted 2-azetidinones using catalytic amounts of molecular iodine under microwave irradiation has been developed. (mdpi.com)
  • Pd, Ru, and Fe catalysis enable a general synthesis of 2-substituted pyrroles in overall good yields with only water and ethene as side-products. (organic-chemistry.org)
  • Herein, we report a new and facile method for the synthesis of 2,5-di and 2,3,5-trisubstituted pyrrole using intramolecular reductive cyclization of the easily accessible nitrodienes as starting material catalyzed by palladium complex and with carbon monoxide as a reductant. (omicsonline.org)
  • A facile and efficient protocol is reported for the synthesis of calix[4]pyrrolesand N-confused calix[4]pyrroles in moderate to excellent yields by reaction of dialkyl orcycloalkyl ketones with pyrrole catalyzed by reusable Amberlyst TM -15 under eco-friendlyconditions. (mdpi.com)
  • The classical Paal-Knorr reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful pyrrole derivatives. (rsc.org)
  • The present procedure for the synthesis of N -(2-azetidinonyl) 2,5-disubstituted pyrroles (1,2,5-trisubstituted pyrroles ) has been accomplished by reacting 3-amino β-lactams and 2,5-hexanedione in the presence of bismuth nitrate pentahydrate as an ecofriendly catalyst using microwave irradiation under solvent free condition. (rsc.org)
  • Pyrrole and its derivatives are widely used as intermediates in synthesis of pharmaceuticals, agrochemicals, dyes, photographic chemicals, perfumes and other organic compounds. (alliedacademies.org)
  • Synthesis of pyrrole derivatives and their utilization for the preparation of pyrolo-pyrimidine scaffold includes various synthetic approaches, one of which has been discussed below. (alliedacademies.org)
  • An alternative approach for the synthesis of various 2,5-bis (guanidinoaryl)-1-methyl-1H-pyrroles was proceeded from 1-methyl-1H-pyrrole via multi-step procedure and were evaluated for antifungal property. (alliedacademies.org)
  • Synthesis of 2,3-disubstituted pyrroles and pyridines from 3-halo-1-azaallylic anions. (ugent.be)
  • Synthesis of 2,3-disubstituted pyrrol. (ugent.be)
  • Aelterman W, De Kimpe N, TYVORSKII V, KULINKOVICH O. Synthesis of 2,3-disubstituted pyrroles and pyridines from 3-halo-1-azaallylic anions. (ugent.be)
  • Synthesis Structure and Complexation Properties of Partially and Completely Reduced meso-Octamethylporphyrinogens (Calix[4]pyrroles). (docme.ru)
  • Communications DOI: 10.1002/anie.200804937 Porphyrinoids Synthesis, Structure, and Complexation Properties of Partially and Completely Reduced meso-Octamethylporphyrinogens (Calix[4]pyrroles)** Valeria Blangy, Christoph Heiss, Vsevolod Khlebnikov, Christophe Letondor, Helen StoeckliEvans,* and Reinhard Neier* Many organic ligands used by nature in important biological processes[1?5] are formed by the condensation of simple starting materials. (docme.ru)
  • Balavar, Yadollah 2015-04-16 00:00:00 A simple, clean, and efficient solvent-free protocol is introduced for Paal-Knorr pyrrole synthesis catalyzed by l-tryptophan as a thermally resistant, natural primary amino acid. (deepdyve.com)
  • The pyrrole ring structure is a component of many biologically important compounds, including porphyrins, alkaloids, and certain amino acids. (dictionary.com)
  • To insure convergence in the least-squares adjustment of force constants, interaction constants were assumed transferable between the furan and pyrrole rings, and observed wave-numbers of the two compounds and their derivatives were used in a single adjustment. (cdc.gov)
  • Pyrrole pyridazine and pyridazinone compounds are described. (google.com)
  • This compound belongs to the class of organic compounds known as substituted pyrroles. (hmdb.ca)
  • These are heterocyclic compounds containing a pyrrole ring substituted at one or more positions. (hmdb.ca)
  • The slight variations observed in the pKa values of the thiophene compound compared to the pyrrol analogue revealed that neither of the two hetero atoms in the pyrrol or thiophene rings, of the two compounds, is involved in a hydrogen bond chelation. (scirp.org)
  • Many active compounds have been developed by amalgamation of different pharmacophores in a pyrrole ring system. (alliedacademies.org)
  • Few biologically active compounds containing pyrrole moiety. (alliedacademies.org)
  • 5-Acetyl-3,4-dihydro-2H-pyrrole, also known as 2AP or APR, belongs to the class of organic compounds known as pyrrolines. (hmdb.ca)
  • These are organic compounds containing an indole, which is a bicyclic ring system made up of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. (drugbank.ca)
  • 15?17] Forty years later the X-ray structure analysis of this class of compounds showed alternating conformations of the pyrrole rings in the solid state. (docme.ru)
  • Substituted derivatives are also called pyrroles, e.g. (wikipedia.org)
  • Pyrrole itself is not naturally occurring, but many of its derivatives are found in a variety of cofactors and natural products. (wikipedia.org)
  • A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity. (hindawi.com)
  • Motivated by the importance of this system and in continuation of our research efforts [ 26 - 30 ], we try to highlight aspects reported on the chemistry of some newly synthesized pyrrole and pyrrolopyrimidine derivatives and evaluate them for the antihyperglycemic activities. (hindawi.com)
  • Process for the preparation of 4-phenyl-pyrrole derivatives. (freepatentsonline.com)
  • A valence force field for furan and pyrrole and their deuterium and methyl derivatives. (cdc.gov)
  • A molecular vibrational analysis was carried out for furan and pyrrole and their deuterium and methyl derivatives to establish vibrational assignments for use in statistical thermodynamic calculations. (cdc.gov)
  • Four new alternating copolymers, P(CPD-T-DPPD), P(CPD-Se-DPPD), P(CPD-T-BDPPD) and P(CPD-Se-BDPPD), containing electron rich cyclopentadithiophene (CPD) and four different pyrrolo[3,4-c]pyrrole-1,3-dione (DPPD) derivatives (T-DPPD, Se-DPPD, T-BDPPD and Se-BDPPD) were prepared using Stille polymerization. (ingentaconnect.com)
  • The high affinities of these pyrrole derivatives relative to JWH-030 (1,R = C5H11) support the hypothesis that these pyrroles interact with the CB, receptor primarily by aromatic stacking. (rti.org)
  • In this review, attempts are made to disclose various tactical approaches to synthesize pyrrole and its derivatives. (alliedacademies.org)
  • Pyrrole and its derivatives are recognized to inhibit reverse transcriptase (human immunodeficiency virus type 1 (HIV-1)) and cellular DNA polymerases protein kinases. (alliedacademies.org)
  • The reaction was initiated using benzoin, antipyrine amine and malononitrile which afforded pyrrole derivative 1 which was further utilized for the preparation of pyrrole derivatives using appropriate reagents and reaction conditions. (alliedacademies.org)
  • The pyrrole derivatives 2a-c were further converted to the corresponding pyrrole[2,3-d] pyrimidines [ 5 ]. (alliedacademies.org)
  • Pyrrole-imidazole polyamides (PIPs) are a class of polyamides have the ability to bind to minor grooves found in the DNA helix. (wikipedia.org)
  • Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI. (nii.ac.jp)
  • 2016) Double β-alanine Substitutions Incorporated in 12-ring Pyrrole-Imidazole Polyamides for Lengthened DNA Minor Groove Recognition. (omicsonline.org)
  • Cyclooctyne-derivatized pyrrole-imidazole polyamides were immobilized on azide-modified glass substrates using microcontact printing and a strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. (strath.ac.uk)
  • McCluskey, A. The influence of ionic liquids on the Knoevenagel condensation of 1H-pyrrole-2-carbaldehyde with phenyl acetonitriles - cytotoxic 3-substituted-(1H-pyrrol-2-yl)acrylonitriles. (alfa.com)
  • In the mol-ecule of the title compound, C 22 H 17 ClN 2 O 2 , the dihedral angles formed by the pyrrole ring with the quinoline and phenyl rings are 67.93 (8) and 28.40 (11)°, respectively. (pubmedcentralcanada.ca)
  • Substitution of pyrrole with alkyl substituents provides a more basic molecule-for example, tetramethylpyrrole has a conjugate acid pKa of +3.7. (wikipedia.org)
  • The product is a pyrrole with substituents at the 3 and 4 positions. (wikipedia.org)
  • In one modification, propionaldehyde is treated first with hydrazine and then with benzoyl chloride at high temperatures and assisted by microwave irradiation: Pyrroles bearing multiple substituents are obtained from the reaction of münchnones and alkynes. (wikipedia.org)
  • A series of quinone-pyrrole dyad polymers has been synthesized with a variety of quinone substituents, demonstrating the adjustability of quinone formal potentials by choice of substituents. (diva-portal.org)
  • Following this method, a series of 3-pyrrole- substituted 2-azetidinones have been synthesized with a variety of substituents at N-1 and at C-4. (mdpi.com)
  • The structural modifications involved the bioisosteric replacement of the pyrazole ring by a pyrrole ring and variations on the amine carbamoyl substituents. (csic.es)
  • Pyrrole is a 5-membered aromatic heterocycle, like furan and thiophene. (wikipedia.org)
  • Pyrrole is prepared industrially by treatment of furan with ammonia in the presence of solid acid catalysts, like SiO2 and Al2O3. (wikipedia.org)
  • It is used as a key starting material for the preparation of pyrrole -2-carboxylic acid by oxidation reaction. (alfa.com)
  • Through structure-based drug design, two isomers of the APHA lead compound 1, the 3-(2-benzoyl-1-methyl-1H-pyrrol-4-yl)-N-hydroxy-2-propenamide 2 and the 3-(2-benzoyl-1-methyl-1H-pyrrol-5-yl)-N-hydroxy-2-propenamide 3 (iso-APHAs) were designed, synthesized and tested in murine leukemia cells as antiproliferative and cytodifferentiating agents. (nih.gov)
  • Cholesterol oxidase (ChOx) has been electrochemically entrapped onto p -toluene sulphonate (PTS) doped poly (pyrrole-co- N -methyl pyrrole) (1:1) on indium-tin-oxide (ITO) glass plates. (springer.com)
  • The electronic properties of pyrrole are important in the context of conducting polymers, where poly-pyrroles have found many useful applications. (omicsonline.org)
  • Herein, we investigate the kinetics of the redox processes occurring in acidic aqueous electrolyte in electropolymerized poly(pyrrol-3-ylhydroquinone), which has been proposed for electrical energy storage applications. (diva-portal.org)
  • In poly(pyrrol-3-ylhydroquinone), a polypyrrole derivative functionalized with hydroquinone units, the redox conversion of the pendant groups has a large impact on the polymer backbone. (diva-portal.org)
  • Pyrrole is a heterocyclic aromatic organic compound, a five-membered ring with the formula C4H4NH. (wikipedia.org)
  • Pyrrole disorder develops when there are too many pyrrole molecules in your body. (healthline.com)
  • Pyrrole molecules don't serve any important function in the body. (healthline.com)
  • If you have too many pyrrole molecules, you may experience noticeable shifts in mood. (healthline.com)
  • It's not uncommon for people with bipolar disorder to also have excess pyrrole molecules. (healthline.com)
  • While the kryptopyrrole test is the only medical diagnostic test to help determine the presence of pyrrole molecules in your system, your doctor may also evaluate your overall mental health. (healthline.com)
  • 2-Azetidinones and pyrroles are two highly important classes of molecules in organic and medicinal chemistry. (mdpi.com)
  • Pyrrole nucleus is one of the most important heterocycles abundantly found in bioactive natural molecules, forming the characteristic subunit of heme, chlorophyll vitamin B12 as well as in melanin pigments. (omicsonline.org)
  • The present procedure for synthesizing N -(2-azetidinonyl) 2,5-disubstituted pyrroles may find application in the development of potent pharmacologically active molecules. (rsc.org)
  • Four molecules of the pyrrole porphobilinogen are condensed to form the linear tetrapyrrole preuro-porphyrinogen (hydroxymethylbilane). (iucr.org)
  • The pyrrole skeleton is an imperative structural framework found in extensive range of biologically active natural products and pharmaceutically active molecules. (alliedacademies.org)
  • 18?20] For this reason the name calix[4]pyrroles was proposed as a trivial name for the meso-octaalkylporphyrinogens. (docme.ru)
  • 19, 30, 31] To obtain Werner-type metal complexes from calix[4]pyrroles the ligand must be deprotonated using butyllithium. (docme.ru)
  • New Cyclic Heptapeptides and Pyrrole-Imidazole Alkaloids from the Caribbean Sponge Stylissa caribica. (awi.de)
  • The chemical investigation of the Caribbean sponge Agelas citrina revealed four new pyrrole-imidazole alkaloids (PIAs), the citrinamines A-D ( 1 - 4 ) and the bromopyrrole alkaloid N -methylagelongine ( 5 ). (beilstein-journals.org)
  • The family of pyrrole-imidazole alkaloids (PIAs) represents a fascinating example of a large variety of secondary metabolites produced exclusively by marine sponges. (beilstein-journals.org)
  • Selected pyrrole-imidazole alkaloids ( 1 - 4 , 6 - 11 , and 13 - 20 ), and agelongine analogues ( 5 , 12 , and 21 ). (beilstein-journals.org)
  • This brings selenophene more akin to pyrrole than thiophene, but the group -NH- in the molecule of pyrrole is an auxochrome. (dictionary.com)
  • Moreover, a series of quinone-pyrrole dyad polymers with various linkers was synthesized, showing that the choice of linker has a pronounced impact on the interactions between the PG and CP. (diva-portal.org)
  • designated as pyrrole-2-carboxylate monooxygenase belongs to the recently discovered new class of two-component flavin aromatic monooxygenases. (nih.gov)
  • All H-atoms were positioned geometrically and refined using a riding model with d(N-H) = 0.88 Å, U iso (H) = 1.2 U eq (C) for pyrrole N, d(C-H) = 0.95 Å, U iso (H) = 1.2 U eq (C) for aromatic C and d(C-H) = 0.99 Å, U iso (H) = 1.2 U eq (C) for CH 2 groups. (pubmedcentralcanada.ca)
  • This is the first example of a synthetic macrocyclic pyrrole-based receptor capable of transmembrane bicarbonate transport. (soton.ac.uk)
  • In this report we demonstrate the pharmacological richness of the pyrrole carboxamide library by the finding that 10 of 172 members inhibited human MKP-1. (aspetjournals.org)
  • By virtue of this strategy a phenol derivative can be readily accessed, which can be transformed in a level-2 transformation to a library of bichromophoric pyrrol-fluorophore conjugates by facile alkylation with fluorophore halides. (frontiersin.org)
  • Pyrrole and 2-azetidinone are two essential heterocyclic scaffolds, which are being broadly used in medicinal chemistry and drug discovery field. (rsc.org)
  • 5-Acetyl-3,4-dihydro-2H-pyrrole is a strong basic compound (based on its pKa). (hmdb.ca)
  • 5-Acetyl-3,4-dihydro-2H-pyrrole is a sweet, ham, and nut tasting compound. (hmdb.ca)
  • A refined model of the colchicine site on tubulin was used to design an improved analog of the pyrrole parent compound, JG-03-14. (aspetjournals.org)
  • Biologically, pyrroles tend to construct the key structure of porphyrin rings, which act as an active moiety in chlorophyll, heme, vitamin B12 or bile pigments [ 2 ]. (alliedacademies.org)
  • Porphobilinogen, a trisubstituted pyrrole, is the biosynthetic precursor to many natural products such as heme. (wikipedia.org)
  • Two series of 1-alkyl-2-aryl-4-(1-naphthoyl)pyrroles were synthesized and their affinities for the cannabinoid CB, and CB2 receptors were determined. (rti.org)
  • 42] Most efficient reductions of alkyl pyrroles require an acid as the solvent or as a component of the solvent mixture. (docme.ru)
  • Precursor labeling studies of some of these natural products have shown that L-proline can serve as the biosynthetic precursor for these moieties, including those found in coumermycin A 1 , pyoluteorin, and one of the pyrroles of undecylprodigiosin. (mendeley.com)
  • Pyrroles are components of more complex macrocycles, including the porphyrinogens and products derived therefrom, including porphyrins of heme, the chlorins, bacteriochlorins, and chlorophylls. (wikipedia.org)
  • The Van Leusen reaction can be used to form pyrroles, by reaction of tosylmethyl isocyanide (TosMIC) with an enone in the presence of base, in a Michael addition. (wikipedia.org)
  • It undergoes condensation reaction to produce pyrrole-2-carboxaldehyde salicylhydrazone (PCSH). (alfa.com)
  • The mild reaction conditions of the palladium-copper coupling-isomerization reaction open a highly convergent, chromogenic route to blue emissive pyrroles in the sense of a consecutive four-component reaction. (frontiersin.org)
  • 1. It has been suggested that 2-amino-6-(2-formyl-5-hydroxymethyl-pyrrol-l-yl)-hexanoic acid ('pyrraline') is formed as an advanced glycation end product in the Maillard reaction under physiological conditions. (portlandpress.com)
  • An unnatural base pair between 7-(2-thienyl)-imidazo[4,5-b]pyridine (Ds) and pyrrole-2-carbaldehyde (Pa) could expand the genetic alphabet and allow the incorporation of non-standard amino acids into proteins at defined positions. (sigmaaldrich.com)
  • The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin. (biomedsearch.com)
  • Pyrrole can also be formed by catalytic dehydrogenation of pyrrolidine. (wikipedia.org)
  • Most methods for the preparation of indoles involve annulation of a benzene precursor, but the method reported herein is unusual in that pyrrole precursors are used. (whiterose.ac.uk)
  • Pyrrole is a privileged scaffold with assorted nature of biological activities. (alliedacademies.org)
  • The syntheses of pyrrole-containing haemin, synthesized by Hans Fischer was recognized by the Nobel Prize. (wikipedia.org)
  • Several syntheses of the pyrrole ring have been described. (wikipedia.org)
  • 3-(Ethoxycarbonyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrole-1-acetic acid ethyl ester (CAS 62613-79-0) Market Research Report 2018 aims at providing comprehensive data on 3-(ethoxycarbonyl)-2,5-dihydro-4-hydroxy-2-oxo-1h-pyrrole-1-acetic acid ethyl ester market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
  • The report includes 3-(ethoxycarbonyl)-2,5-dihydro-4-hydroxy-2-oxo-1h-pyrrole-1-acetic acid ethyl ester description, covers its application areas, manufacturing methods, patents. (marketpublishers.com)
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  • 3-(Ethoxycarbonyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrole-1-acetic acid ethyl ester (CAS 62613-79-0) Market Research Report 2018 contents were prepared and placed on the website in March, 2018. (marketpublishers.com)
  • Evaluation of the pyrrole insecticide chlorfenapyr against pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae). (www.gov.uk)
  • To evaluate the pyrrole insecticide chlorfenapyr, which has a novel non-neurotoxic mode of action and is a promising alternative to conventional adulticides, against Anopheles funestus. (www.gov.uk)
  • Two important DPP-IV inhibitors, having a pyrrole and fused pyrrole, vildaglipin, and saxagliptin [ 24 , 25 ], are on the market in many countries, as shown in Figure 2(b) . (hindawi.com)
  • New pyrrole-based histone deacetylase inhibitors: binding mode, enzyme- and cell-based investigations. (nih.gov)
  • The lack of readily available selective MKP-1 inhibitors has severely limited interrogation of its biological role and was one rationale for using a recently described tricyclic pyrrole-2-carboxamide library in our screening efforts. (aspetjournals.org)
  • Two of the pyrrole carboxamides, PSI2106 and MDF2085, were especially notable in vitro inhibitors of recombinant human MKP-1 enzyme activity with IC 50 values of 8.0 ± 0.9 and 8.3 ± 0.8 μM, respectively. (aspetjournals.org)
  • This establishes a novel mechanism for pyrrole biosynthesis and extends the hypothesis that organisms use A/PCP pairs to partition an amino acid into secondary metabolism. (mendeley.com)
  • Several medically and agriculturally important natural products contain pyrrole moieties. (mendeley.com)
  • Some individuals may excrete more HPL (pyrroles) than others, which indicates a toxic level of the enzyme in their body. (healthline.com)
  • Pyrrole-2-carboxylate can serve as the sole source of carbon, nitrogen, and energy for a strain tentatively identified to belong to the genus Rhodococcus. (nih.gov)
  • Two clinical examples of pyrroles displaying this pattern of substitution are amtolmetin and tolmetin (non-steroidal anti-inflammatory agents). (omicsonline.org)
  • It is also used to prepare 4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY dyes) through condensation with a pyrrole, which is an important probes for biotechnology and other applications. (alfa.com)
  • These intermediates are further converted to a wide range of polysubstituted pyrroles through double bond transposition and Alder-ene reactions. (organic-chemistry.org)
  • Density Functional Theory (DFT) studies suggest that these reactions proceed via initial activation of the pyrrole C-3 position before undergoing subsequent rearrangement, contradicting the conventional wisdom that pyrroles are more nucleophilic through C-2. (whiterose.ac.uk)
  • Pyrrole was first detected by F. F. Runge in 1834, as a constituent of coal tar. (wikipedia.org)
  • Pyrroles can be prepared by silver-catalyzed cyclization of alkynes with isonitriles, where R2 is an electron-withdrawing group, and R1 is an alkane, aryl group, or ester. (wikipedia.org)

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