Uveitis. Medical search

Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.

Inflammation of the choroid as well as the retina and vitreous body. Some form of visual disturbance is usually present. The most important characteristics of posterior uveitis are vitreous opacities, choroiditis, and chorioretinitis.

Inflammation of the pars plana, ciliary body, and adjacent structures.

Inflammation in which both the anterior and posterior segments of the uvea are involved and a specific focus is not apparent. It is often severe and extensive and a serious threat to vision. Causes include systemic diseases such as tuberculosis, sarcoidosis, and syphilis, as well as malignancies. The intermediate segment of the eye is not involved.

The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)

Acute or chronic inflammation of the iris and ciliary body characterized by exudates into the anterior chamber, discoloration of the iris, and constricted, sluggish pupil. Symptoms include radiating pain, photophobia, lacrimation, and interference with vision.

Intraocular infection caused mainly by pus-producing bacteria and rarely by fungi. The infection may be caused by an injury or surgical wound (exogenous) or by endogenous septic emboli in such diseases as bacterial endocarditis or meningococcemia.

Tuberculous infection of the eye, primarily the iris, ciliary body, and choroid.

Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.

Inflammation of the retinal vasculature with various causes including infectious disease; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; BEHCET SYNDROME; and CHORIORETINITIS.

The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.

Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.

A syndrome characterized by bilateral granulomatous UVEITIS with IRITIS and secondary GLAUCOMA, premature ALOPECIA, symmetrical VITILIGO, poliosis circumscripta (a strand of depigmented hair), HEARING DISORDERS, and meningeal signs (neck stiffness and headache). Examination of the cerebrospinal fluid reveals a pattern consistent with MENINGITIS, ASEPTIC. (Adams et al., Principles of Neurology, 6th ed, p748; Surv Ophthalmol 1995 Jan;39(4):265-292)

Arthritis of children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.

The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.

Infection caused by the protozoan parasite TOXOPLASMA in which there is extensive connective tissue proliferation, the retina surrounding the lesions remains normal, and the ocular media remain clear. Chorioretinitis may be associated with all forms of toxoplasmosis, but is usually a late sequel of congenital toxoplasmosis. The severe ocular lesions in infants may lead to blindness.

A 48-Kd protein of the outer segment of the retinal rods and a component of the phototransduction cascade. Arrestin quenches G-protein activation by binding to phosphorylated photolyzed rhodopsin. Arrestin causes experimental autoimmune uveitis when injected into laboratory animals.

A ring of tissue extending from the scleral spur to the ora serrata of the RETINA. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion.

Inflammation of the choroid in which the sensory retina becomes edematous and opaque. The inflammatory cells and exudate may burst through the sensory retina to cloud the vitreous body.

The pigmented vascular coat of the eyeball, consisting of the CHOROID; CILIARY BODY; and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)

Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.

Proteins which bind with RETINOL. The retinol-binding protein found in plasma has an alpha-1 mobility on electrophoresis and a molecular weight of about 21 kDa. The retinol-protein complex (MW=80-90 kDa) circulates in plasma in the form of a protein-protein complex with prealbumin. The retinol-binding protein found in tissue has a molecular weight of 14 kDa and carries retinol as a non-covalently-bound ligand.

Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.

Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.

Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).

Diseases affecting the eye.

An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.

A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)

Inflammation of the choroid.

The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)

Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Mild to fulminant necrotizing vaso-occlusive retinitis associated with a high incidence of retinal detachment and poor vision outcome.

Bleeding in the anterior chamber of the eye.

Diseases of domestic and wild horses of the species Equus caballus.

Form of granulomatous uveitis occurring in the region of the pars plana. This disorder is a common condition with no detectable focal pathology. It causes fibrovascular proliferation at the inferior ora serrata.

A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.

The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.

The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Granulomatous uveitis which follows in one eye after a penetrating injury to the other eye; the secondarily affected eye is called the sympathizing eye, and the injured eye is called the exciting or activating eye.

Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.

The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)

Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90)

Substances that reduce or suppress INFLAMMATION.

Inflammation of the joints of the SPINE, the intervertebral articulations.

Disease having a short and relatively severe course.

Tumors or cancer of the EYE.

Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.

Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

Abnormally low intraocular pressure often related to chronic inflammation (uveitis).

Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Removal of the whole or part of the vitreous body in treating endophthalmitis, diabetic retinopathy, retinal detachment, intraocular foreign bodies, and some types of glaucoma.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Infections with bacteria of the genus LEPTOSPIRA.

A republic in western Africa, south of GUINEA and west of LIBERIA. Its capital is Freetown.

Virus infection of the Gasserian ganglion and its nerve branches characterized by pain and vesicular eruptions with much swelling. Ocular involvement is usually heralded by a vesicle on the tip of the nose. This area is innervated by the nasociliary nerve.

A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.

The administration of substances into the eye with a hypodermic syringe.

A procedure in which fluid is withdrawn from a body cavity or organ via a trocar and cannula, needle, or other hollow instrument.

Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.

Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from EYE DISEASES; OPTIC NERVE DISEASES; VISUAL PATHWAY diseases; OCCIPITAL LOBE diseases; OCULAR MOTILITY DISORDERS; and other conditions (From Newell, Ophthalmology: Principles and Concepts, 7th ed, p132).

Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)

A pathologic process consisting in the formation of pus.

The return of a sign, symptom, or disease after a remission.

Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)

The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.

The removal of a cataractous CRYSTALLINE LENS from the eye.

Inflammation of the iris characterized by circumcorneal injection, aqueous flare, keratotic precipitates, and constricted and sluggish pupil along with discoloration of the iris.

The front third of the eyeball that includes the structures between the front surface of the cornea and the front of the VITREOUS BODY.

The selectively permeable barrier, in the EYE, formed by the nonpigmented layer of the EPITHELIUM of the CILIARY BODY, and the ENDOTHELIUM of the BLOOD VESSELS of the IRIS. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.

Mild to severe infections of the eye and its adjacent structures (adnexa) by adult or larval protozoan or metazoan parasites.

Pregnane derivatives containing two double bonds anywhere within the ring structures.

Introduction of substances into the body using a needle and syringe.

A genus of aerobic, helical spirochetes, some species of which are pathogenic, others free-living or saprophytic.

A form of malignant cancer which occurs within the eyeball.

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*51 allele family.

Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.

The inability to see or the loss or absence of perception of visual stimuli. This condition may be the result of EYE DISEASES; OPTIC NERVE DISEASES; OPTIC CHIASM diseases; or BRAIN DISEASES affecting the VISUAL PATHWAYS or OCCIPITAL LOBE.

An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.

Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics.

Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.

Insertion of an artificial lens to replace the natural CRYSTALLINE LENS after CATARACT EXTRACTION or to supplement the natural lens which is left in place.

A polysymptomatic condition believed by clinical ecologists to result from immune dysregulation induced by common foods, allergens, and chemicals, resulting in various physical and mental disorders. The medical community has remained largely skeptical of the existence of this "disease", given the plethora of symptoms attributed to environmental illness, the lack of reproducible laboratory abnormalities, and the use of unproven therapies to treat the condition. (From Segen, Dictionary of Modern Medicine, 1992)

A dull or sharp painful sensation associated with the outer or inner structures of the eyeball, having different causes.

An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

The surgical removal of the eyeball leaving the eye muscles and remaining orbital contents intact.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other BIOGENIC AMINES and NEUROPEPTIDES.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Experimental animal models for human AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM. They include GUILLAIN-BARRE SYNDROME (see NEURITIS, AUTOIMMUNE, EXPERIMENTAL); MYASTHENIA GRAVIS (see MYASTHENIA GRAVIS, AUTOIMMUNE, EXPERIMENTAL); and MULTIPLE SCLEROSIS (see ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL).

A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.

A specialized transport barrier, in the EYE, formed by the retinal pigment EPITHELIUM, and the ENDOTHELIUM of the BLOOD VESSELS of the RETINA. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.

Substances that are recognized by the immune system and induce an immune reaction.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.

Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.

A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.

Insoluble polymers of TYROSINE derivatives found in and causing darkness in skin (SKIN PIGMENTATION), hair, and feathers providing protection against SUNBURN induced by SUNLIGHT. CAROTENES contribute yellow and red coloration.

Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.

IL-4 and IL-10 are both required for the induction of oral tolerance. (1/1070)

Protection from the development of experimental autoimmune uveitis (EAU) can be induced by feeding mice interphotoreceptor retinoid binding protein before uveitogenic challenge with the same protein. Two different regimens are equally effective in inducing protective tolerance, although they seem to do so through different mechanisms: one involving regulatory cytokines (IL-4, IL-10, and TGF-beta), and the other with minimal involvement of cytokines. Here we studied the importance of IL-4 and IL-10 for the development of oral tolerance using mice genetically engineered to lack either one or both of these cytokines. In these animals we were able to protect against EAU only through the regimen inducing cytokine-independent tolerance. When these animals were fed a regimen that in the wild-type animal is thought to predominantly induce regulatory cells and is associated with cytokine secretion, they were not protected from EAU. Interestingly, both regimens were associated with reduced IL-2 production and proliferation in response to interphotoreceptor retinoid binding protein. These findings indicate that both IL-4 and IL-10 are required for induction of protective oral tolerance dependent on regulatory cytokines, and that one cytokine cannot substitute for the other in this process. These data also underscore the fact that oral tolerance, manifested as suppression of proliferation and IL-2 production, is not synonymous with protection from disease. (+info)

Pregnancy ameliorates induction and expression of experimental autoimmune uveitis. (2/1070)

Female patients suffering from autoimmune uveitis are reported to experience a temporary remission during pregnancy. Experimental autoimmune uveitis (EAU) is a model for human uveitis. Here we examine the effect of pregnancy on the development of EAU and its associated immunological responses. Susceptible C57BL/6 mice were immunized with interphotoreceptor retinoid-binding protein (IRBP). EAU scores and Ag-specific responses were evaluated 21 days later. Mice immunized during pregnancy developed significantly less EAU than nonpregnant controls. Their lymph node cells and splenocytes produced a distinct pattern of cytokines in response to IRBP: reduced IFN-gamma and IL-12 p40, but unchanged levels of TNF-alpha, IL-4, IL-5, and IL-10. Anti-IRBP Ab isotypes revealed an up-regulation of IgG1, indicating a possible Th2 bias at the humoral level. Ag-specific proliferation and delayed hypersensitivity, as well as mitogen-induced IFN-gamma production, remained undiminished, arguing against an overall immune deficit. Interestingly, pregnant mice that received an infusion of IRBP-primed lymphoid cells from nonpregnant donors also developed reduced EAU, suggesting that pregnancy suppresses not only the generation, but also the function of mature uveitogenic effector T cells. Pregnant mice at the time of immunization exhibited elevated levels of TGF-beta, but not of IL-10, in the serum. We suggest that protection from EAU during pregnancy is due primarily to a selective reduction of Ag-specific Th1 responses with only marginal enhancement of Th2 function, and that these effects may in part be secondary to elevated systemic levels of TGF-beta. (+info)

Protective effect of the type IV phosphodiesterase inhibitor rolipram in EAU: protection is independent of IL-10-inducing activity. (3/1070)

PURPOSE: Experimental autoimmune uveoretinitis (EAU) is a cell-mediated model of retinal autoimmunity that is negatively regulated by interleukin (IL)-10. The antidepressant drug rolipram, a type IV phosphodiesterase inhibitor, enhances IL-10 production by monocyte/macrophages. The effect of rolipram on induction of EAU and its associated immunologic responses was investigated. METHODS: Mice were challenged for EAU induction by immunization with the retinal antigen interphotoreceptor retinoid-binding protein (IRBP) or by adoptive transfer of uveitogenic T cells and were treated with rolipram. EAU severity and immunologic responses to IRBP were analyzed. In addition, the effect of rolipram added to the culture on antigen-driven responses of primed lymph node cells was tested. RESULTS: Rolipram treatment from days -1 to 7 after immunization (afferent phase) was not protective, but severity of EAU was reduced to 50% by treatment from days 8 to 16 after immunization or when EAU was induced by adoptive transfer (efferent phase). Antigen-specific proliferation and interferon (IFN)-gamma production ex vivo by lymph node cells of protected mice were not reduced. However, the addition of rolipram directly to the culture suppressed IRBP-driven proliferation and IFN-gamma production by primed lymph node cells. Freshly explanted lymph node cells of treated mice showed inhibition of IFN-gamma mRNA but no parallel enhancement of IL-10 mRNA by quantitative polymerase chain reaction. Rolipram inhibited EAU in IL-10 knockout mice equally well compared with controls and suppressed their primed lymph node cells in culture. CONCLUSIONS: Rolipram appears to inhibit the expansion and effector function of uveitogenic T cells, raising the possibility that it may be useful for treatment of established disease. Contrary to expectations based on in vitro studies, the protective effects in vivo appear to be independent of IL-10. The observation that suppression of antigen-specific responses is demonstrable only in the physical presence of the drug suggests that, in a clinical setting, continuous administration of rolipram might be needed to sustain its therapeutic effect. (+info)

Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis. (4/1070)

PURPOSE: Nitric oxide (NO) is an important mediator of inflammatory tissue damage. The present study addresses the question whether inducible nitric oxide synthase (iNOS), and consequently the ability to upregulate NO, is required to effect the pathogenesis of experimental autoimmune uveoretinitis (EAU) in mice. METHODS: Mice with a homologous disruption of the iNOS gene (iNOS KO) were evaluated for their ability to develop EAU and associated cellular responses after immunization with the interphotoreceptor retinoid-binding protein. EAU was determined by histopathology 21 days after uveitogenic immunization, and antigen-specific cellular responses were assessed by delayed type hypersensitivity and lymphocyte proliferation. RESULTS: iNOS knockout (iNOS KO) mice developed EAU with scores similar to wild-type mice and exhibited good cellular responses to the immunizing antigen. CONCLUSIONS: A functional iNOS gene is not necessary for EAU pathogenesis. Therefore, upregulation of NO is not required to mediate autoimmune tissue damage in the eye. (+info)

Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. (5/1070)

The present study attempts to identify specific genetic loci contributing to experimental autoimmune uveoretinitis (EAU) susceptibility in F2 progeny of resistant Fischer (F344/N) and susceptible Lewis (LEW/N) inbred rats. F2 progeny of F344/N x LEW/N inbred rats were immunized with the R16 peptide of interphotoreceptor retinoid-binding protein (IRBP). A genome-wide scan was conducted using 125 simple sequence length polymorphism markers in selected F2 animals that developed severe eye disease or remained unaffected to identify phenotype:genotype co-segregation. The F2 population (n = 1287) demonstrated a wide range of histologically assessed EAU scores (assessed on a scale of 0-4). The disease incidence and severity were not consistent with a simple Mendelian inheritance model. Of the F2 hybrid rats, 60% developed EAU, implying the existence of a potent susceptibility locus with incomplete penetrance associated with the LEW genome or a more complex polygenic model of inheritance. Two genomic regions, on chromosomes 4 and 12, showed strong genetic linkage to the EAU phenotype (P < 0.0016), suggesting the presence of susceptibility loci in these chromosomal regions. In conclusion, we have identified two genomic candidate intervals from D4Arb8 to D4Mit17 on chromosome 4 and from the chromosome end to D12Arb8 on chromosome 12, that appear to influence EAU susceptibility in LEW/F344 rats. Further analysis of these genomic regions may lead to identification of the susceptibility genes and to characterization of their function. (+info)

Iris crystals in chronic uveitis. (6/1070)

AIMS: To analyse the unusual physical sign of iris crystals occurring in patients with uveitis. METHODS: Demographic details and clinical features were documented in 24 patients with chronic uveitis and iris crystals. Plasma immunoglobulin subclasses were measured, and a histopathological review of iridectomy specimens from 33 patients with chronic uveitis was also undertaken. RESULTS: The mean age of patients was 38 years, with a slight preponderance of females. 17 patients had Fuchs' heterochromic cyclitis although a number of other uveitis entities were represented. There was no correlation between severity of clinical signs and presence of iris crystals. Over a mean follow up period of 15 months no significant change in the number, size, or position of the crystals was seen except in four patients who underwent intraocular surgery. Only three patients had raised plasma IgG1. The review of the histology of iridectomy specimens failed to show evidence of Russell body formation in any patient. CONCLUSIONS: Iris crystals appear to be rare but may be underreported as they are small and can easily be missed. They are likely to be associated with disease processes in which there is active immunoglobulin production within the anterior chamber, such as Fuchs' heterochromic cyclitis. (+info)

Immunopathology of pineal glands from horses with uveitis. (7/1070)

PURPOSE: Pinealitis accompanying uveitis is well established in laboratory models of experimental autoimmune uveoretinitis. In naturally occurring uveitis, pinealitis has been demonstrated in the pineal gland from a mare with active uveitis and is suspected in some human uveitides. We have evaluated pineal glands from horses with various stages of uveitis for signs of immunopathology accompanying spontaneous uveitis. METHODS: Pineal glands from 10 horses with uveitis and from 13 horses without uveitis were evaluated for histochemical (H&E, collagen) and immunohistochemical (MHC class II antigen expression, infiltration of T and B lymphocytes, and glial fibrillary acidic protein (GFAP) and vimentin upregulation) evidence of inflammation. RESULTS: Septal areas of pineal glands from horses with uveitis had clusters of MHC class II antigen-expressing cells, T lymphocytes, and enhanced collagen deposition. These changes were not as readily observed in pineal glands from horses without uveitis. B lymphocytes were detected only in the pineal gland from the one mare with active uveitis in which T and B lymphocytes were organized into follicles. No differences in GFAP or vimentin immunoreactivity were noted in pineal glands from horses with or without uveitis. CONCLUSIONS: These pineal gland changes suggest that the pinealitis associated with equine uveitis is transient just as the uveitis of these horses is recurrent. Study of pineal glands from horses with clinically documented uveitis allows demonstration of subtle pineal changes associated with natural uveitis. Similar changes would be difficult to document in human patient populations. (+info)

Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial. (8/1070)

To evaluate the safety and potential therapeutic activity of humanized anti-IL-2 receptor mAb (Daclizumab) therapy in the treatment of patients with severe, sight-threatening, intermediate and posterior noninfectious uveitis, a nonrandomized, open-label, pilot study was performed. Patients with uveitis were treated with a minimum of 20 mg of prednisone, cyclosporine, antimetabolites, or any combination of these agents were eligible. Patients were weaned off their systemic immunosuppressive agents according to a standardized schedule, while ultimately receiving Daclizumab infusions every 4 weeks. Anti-IL-2 receptor antibody therapy, given intravenously with intervals of up to 4 weeks in lieu of standard immunosuppressive therapy, appeared to prevent the expression of severe sight-threatening intraocular inflammatory disease in 8 of 10 patients treated over a 12-month period, with noted improvements in visual acuity. One patient met a primary endpoint with a loss of vision of 10 letters or more from baseline in one eye and another patient discontinued therapy because of evidence of increased ocular inflammation. All patients were able to tolerate the study medications without the need for dose reduction. We report effective long-term use of anti-IL-2 therapy for an autoimmune indication. These initial findings would suggest that anti-IL-2 receptor therapy may be an effective therapeutic approach for uveitis and, by implication, other disorders with a predominant Th1 profile. (+info)

Pan-uveitis is the inflammation of all layers of the uvea(Iris, ciliary body and choroid). Uveitis is usually an isolated ... In anterior uveitis, no associated condition or syndrome is found in approximately one-half of cases. However, anterior uveitis ... Anterior uveitis (iridocyclytis) is the most common, with the incidence of uveitis overall affecting approximately 1:4500, most ... In western countries, anterior uveitis accounts for between 50% and 90% of uveitis cases. In Asian countries the proportion is ...

https://en.wikipedia.org/wiki/Uveitis

... is a form of uveitis localized to the vitreous and peripheral retina. Primary sites of inflammation ... As such, intermediate uveitis may be the first expression of a systemic condition. Infectious causes of intermediate uveitis ... In the United States the proportion of patients with intermediate uveitis is estimated to be 4-8% of uveitis cases in referral ... In the pediatric population, intermediate uveitis can account for up to 25% of uveitis cases. Brady CJ, Villanti AC, Law HA, ...

https://en.wikipedia.org/wiki/Intermediate_uveitis

Gilger, BC; Hollingsworth, SR (2016). "Chapter 8: Diseases of the uvea, uveitis and recurrent uveitis". In Gilger, BC (ed.). ... "Equine Recurrent Uveitis". Archived from the original on 2011-07-10. Retrieved 2010-11-28. Maggs, D; Miller, P; Ofri, R, eds. ( ... Equine recurrent uveitis (ERU) - also known as moon blindness, recurrent iridocyclitis, or periodic ophthalmia - is an acute, ... 2013). "Chapter 11: Uvea: Equine recurrent uveitis". Slatter's fundamentals of veterinary ophthalmology (5th ed.). St. Louis, ...

https://en.wikipedia.org/wiki/Equine_recurrent_uveitis

... (TINU) is a rare medical condition in which there is uveitis (inflammation of the uvea ... Mackensen, F; Billing, H (November 2009). "Tubulointerstitial nephritis and uveitis syndrome". Current Opinion in Ophthalmology ... "Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new ... in the eye) together with tubulointerstitial nephritis (inflammation of the tubules inside the kidney). Uveitis may cause pain ...

https://en.wikipedia.org/wiki/Tubulointerstitial_nephritis_and_uveitis

"Uveitis-Glaucoma-Hyphema Syndrome - EyeWiki". eyewiki.aao.org. Austin R, Fox; Jason P, Kam; Wallase L.M, Alward. "Uveitis ... Uveitis-glaucoma-hyphaema (UGH) syndrome, also known as Ellingson syndrome, is a complication of cataract surgery, caused by ... IPUGH is defined as bleeding into the posterior chamber with/ without glaucoma and no uveitis. UGH Plus is defined as a UGH ... Du, Yu; Zhu, Xiangjia; Yang, Jin; Zhang, Yinglei; Cai, Lei; Lu, Yi (10 January 2020). "Uveitis-glaucoma-hyphema syndrome with ...

https://en.wikipedia.org/wiki/Uveitis–glaucoma–hyphema_syndrome

Anterior uveitis: ICGA is rarely indicated in anterior uveitis, but it might be used to find out associated choroidal pathology ... ISBN 978-93-5152-657-5. John F, Salmon (2020). "Uveitis". Kanski's clinical ophthalmology : a systematic approach (9th ed.). ... Sympathetic ophthalmia: Sympathetic ophthalmia is a bilateral, granulomatous form of uveitis. In sympathetic ophthalmia, ...

https://en.wikipedia.org/wiki/Indocyanine_green_angiography

8th International Symposium on Uveitis (PDF), International Uveitis Study Group, 2012, p. 7, archived from the original (PDF) ... Rosenbaum, JT (1989). "Uveitis. An internist's view". Archives of Internal Medicine. 149 (5): 1173-6. doi:10.1001/archinte. ... He is recognized for his description of an animal model of uveitis (inflammation inside the eye) resulting from injection of ... Rosenbaum, JT; McDevitt, HO; Guss, RB; Egbert, PR (1980). "Endotoxin-induced uveitis in rats as a model for human disease". ...

https://en.wikipedia.org/wiki/James_T._Rosenbaum

cite web}}: Check ,url= value (help) John F, Salmon (13 December 2019). "Uveitis". Kanski's clinical ophthalmology : a ... ISBN 978-0-7020-7711-1. Basic and Clinical Science Course; Intraocular inflammation and uveitis (2011-2012 ed.). American ...

https://en.wikipedia.org/wiki/Multiple_evanescent_white_dot_syndrome

"History". Uveitis Society of India. 2017. Archived from the original on 1 April 2017. "Executive Team". Uveitis Society of ... Foster". Uveitis.org. 2017. Archived from the original on 6 October 2016. "Biography on Orcid". Orcid. 2017. Archived from the ... Known for his research on limbal stem cells, Sangwan is the founder secretary and an adviser of the Uveitis Society of India. ... This gave him the opportunity to interact with the pioneers of uveitis treatment in India such as Narsing A. Rao, Amod Gupta, ...

https://en.wikipedia.org/wiki/V._S._Sangwan

The most common ophthalmologic manifestation of sarcoidosis is uveitis. The combination of anterior uveitis, parotitis, VII ... Between 1909 and 1910 uveitis in sarcoidosis was first described, and later in 1915 it was emphasised, by Dr. Jörgen Nielsen ... Manifestations in the eye include uveitis, uveoparotitis, and retinal inflammation, which may result in loss of visual acuity ... Jamilloux Y, Kodjikian L, Broussolle C, Sève P (August 2014). "Sarcoidosis and uveitis". Autoimmunity Reviews. 13 (8): 840-9. ...

https://en.wikipedia.org/wiki/Sarcoidosis

Eales disease, pars planitis, birdshot retinochoroidopathy (autoimmune bilateral posterior uveitis), and Fuchs heterochromic ... American Uveitis Society. Archived from the original on July 31, 2010. Retrieved December 10, 2010.{{cite web}}: CS1 maint: ...

https://en.wikipedia.org/wiki/Retinal_vasculitis

Chronic uveitis and intermediate uveitis can be a cause. Blockage of a vein in the retina can cause engorgement of the other ... Anti‐tumour necrosis factor agents have been proposed as a treatment for macular oedema due to uveitis but a Cochrane Review ... "Complications of Uveitis". Her Majesty's Government, UK. 27 January 2015. Retrieved 30 January 2016. Lusby FW (8 May 2014). " ... Diabetic retinopathy Fuchs spot Intermediate uveitis Macular telangiectasia 'Oedema' is the standard form defined in the ...

https://en.wikipedia.org/wiki/Macular_edema

Among the aftereffects of Ebola virus disease, uveitis and optic nerve disease could appear after an individual is discharged. ... Sixty-three per cent reported having eye problems including two who were diagnosed with uveitis, 75% reported psychological or ... Problems he was seeing included chronic pain, sometimes so severe that walking was difficult; eye problems, including uveitis; ... In treating such individuals, the WHO recommends urgent intervention if uveitis is suspected; this consists mainly of ...

https://en.wikipedia.org/wiki/Western_African_Ebola_virus_epidemic

Foster, C. Stephen; Vitale, Albert T. (2013-03-30). Diagnosis & Treatment of Uveitis. JP Medical Ltd. p. 449. ISBN ...

https://en.wikipedia.org/wiki/Cytomegalovirus_retinitis

The acute uveitis]phase of VKH is usually responsive to high-dose oral corticosteroids; parenteral administration is usually ... The chronic recurrent phase may be marked by repeated bouts of uveitis, but is more commonly a chronic, low-grade, often ... The disease is characterised by bilateral diffuse uveitis, with pain, redness and blurring of vision. The eye symptoms may be ... The most significant manifestation is bilateral, diffuse uveitis, which affects the eyes. VKH may variably also involve the ...

https://en.wikipedia.org/wiki/Vogt–Koyanagi–Harada_disease

Consequently, about 3-10% of those with uveitis in developed countries, and about 25% of those with uveitis in the developing ... posterior or pan uveitis. In other words, uveitis diseases tend to be classified by their anatomic location in the eye (e.g. ... That is, uveitis refers to a complex category of ocular diseases that can cause blindness if either left untreated or ... In addition, uveitis is a diverse category of eye diseases that are subdivided as granulomatous (or tumorous) or non- ...

https://en.wikipedia.org/wiki/Visual_impairment

"Post kala-azar uveitis." British Journal of Ophthalmology 64.9 (1980): 680-683. Pampiglione, S., et al. "Studies in ...

https://en.wikipedia.org/wiki/Blasio_Vincent_Ndale_Esau_Oriedo

Uveitis-Glaucoma-Hyphema syndrome: This is a complication of cataract surgery caused due to the mechanical irritation of ... Zemba M, Camburu G (2017). "Uveitis-Glaucoma-Hyphaema Syndrome. General review". Romanian Journal of Ophthalmology. 61 (1): 11- ...

https://en.wikipedia.org/wiki/Cataract_surgery

Equine Recurrent Uveitis (ERU) is also present in the breed. Appaloosas have an eightfold greater risk of developing Equine ... Uveitis in horses has many causes, including eye trauma, disease, and bacterial, parasitic and viral infections, but ERU is ... Up to 80% of all uveitis cases are found in Appaloosas, with physical characteristics including light colored coat patterns, ... Sandmeyer, Lynne (July 28, 2008). "Equine Recurrent Uveitis (ERU)". The Appaloosa Project. Archived from the original on April ...

https://en.wikipedia.org/wiki/Leopard_complex

Uveitis in horses has many causes, including eye trauma, disease, and bacterial, parasitic and viral infections, but ERU is ... Appaloosas have an eightfold greater risk of developing Equine Recurrent Uveitis (ERU) than all other breeds combined. Up to 25 ... Eighty percent of all uveitis cases are found in Appaloosas with physical characteristics including roan or light-colored coat ... Sandmeyer, Lynne (July 28, 2008). "Equine Recurrent Uveitis (ERU)". The Appaloosa Project. Archived from the original on April ...

https://en.wikipedia.org/wiki/Appaloosa

Hyphema Uveitis Huang, John H.; Gaudio, Paul A., eds. (2010). "Hypopyon". Ocular Inflammatory Disease and Uveitis: Diagnosis ... It is a sign of inflammation of the anterior uvea and iris, i.e. iritis, which is a form of anterior uveitis. The exudate ...

https://en.wikipedia.org/wiki/Hypopyon

"The Ocular Immunology and Uveitis Foundation Preferred Practice Patterns of Uveitis Management". Survey of Ophthalmology. pp. 1 ... This standard of care in treating uveitis/OID was published in July 2015 as the preferred practice patterns in the Journal of ... Foster is a member of the American Ophthalmology Society and American Uveitis Society. As of Spring 2016, his work had been ... In 1980, he created its first ocular immunology service, and created the Uveitis and Ocular Immunology Fellowship to train ...

https://en.wikipedia.org/wiki/C._Stephen_Foster

There is mild anterior uveitis. A cherry-red spot may be seen in the macula, along with cotton-wool spots elsewhere, due to ...

https://en.wikipedia.org/wiki/Ocular_ischemic_syndrome

Uveitis: estimated at 0.18 percent. For climbers - Although the cornea usually is thinner after LASIK, because of the removal ... Suarez E, Torres F, Vieira JC, Ramirez E, Arevalo JF (October 2002). "Anterior uveitis after laser in situ keratomileusis". ...

https://en.wikipedia.org/wiki/LASIK

ISSN 1016-264X doi:10.1024/1016-264X.19.1.7 Chu, David S. (MD) (2001). Ocular Immunology and Uveitis Foundation. https://web. ... archive.org/web/20160304061225/http://www.uveitis.org/docs/dm/punctate_inner_choroiditis.pdf Sihota, Ramanjit. Tandon, Radhika ...

https://en.wikipedia.org/wiki/Photopsia

Noninfectious uveitis is the most common form of uveitis in developed countries. Approximately 30% of uveitis patients develop ... Uveitis, as well as steroid treatment for uveitis, can cause an increased resistance to the flow of aqueous humour (the clear ... In some chronic uveitis cases, the pressure inside the eye waxes and wanes due to the uveitis flare-ups. Elevated pressure ... When uveitis is acute, the onset of inflammation is rapid, with obstruction of intertrabecular spaces. When uveitis is chronic ...

https://en.wikipedia.org/wiki/Uveitic_glaucoma

He was honorary secretary of the International Uveitis Study Group, and was the 2013 Duke Elder Lecturer at the Royal College ... Under the supervision of Aize Kijlstra, he undertook extensive laboratory research into human and animal models of uveitis and ... Sandwell and West Birmingham Hospitals NHS Trust where he holds regional and supraregional referral Uveitis clinics. Murray is ... mainly studying T-lymphocyte subsets in uveitis. In 1985 he began clinical ophthalmology training at Moorfield's Eye Hospital ...

https://en.wikipedia.org/wiki/Philip_I._Murray

Steroid eye drops are usually the first line treatment for anterior uveitis. However, other treatments - many of which also ... Poorly controlled chronic anterior uveitis may result in permanent eye damage, including blindness.[citation needed] Systemic ... Sen, Ethan S.; Dick, Andrew D.; Ramanan, Athimalaipet V. (31 March 2015). "Uveitis associated with juvenile idiopathic ... uveitis), particularly in younger patients. The prefixes oligo- and pauci- mean 'few'.[citation needed] There are several other ...

https://en.wikipedia.org/wiki/Juvenile_idiopathic_arthritis

He was also interested in uveitis; in 1964 he listed 130 different diseases in which uveitis may happen. The eponymous "Amsler- ...

https://en.wikipedia.org/wiki/Florian_Verrey

Clinical Uveitis Research Award from the German Uveitis Patient Interest Group, EyeCare America, Lifetime Volunteer Physician ... Douglas Jabs is an American ophthalmologist and an expert in clinical research in the fields of ophthalmology and uveitis. Jabs ... "Multicenter Uveitis Steroid Treatment (MUST) Trial; clinicaltrials.gov". Retrieved 2010-04-28. Jabs DA, Nussenblatt RB, ... Jabs currently chairs both the Study of Ocular Complications of AIDS (SOCA) Research Group and the Multicenter Uveitis Steroid ...

https://en.wikipedia.org/wiki/Douglas_Jabs

... clinicians should be alert to the possibility of uveitis. Patients should be instructed to report symptoms of uveitis (i.e., ... Uveitis is rare when rifabutin is used as a single agent at 300 mg/day for prophylaxis of MAC in HIV-infected persons, even ... Uveitis Associated with Rifabutin Therapy In 1993, the Public Health Service Task Force recommended use of Mycobutin * ( ... Uveitis has occurred among participants in several trials for treatment and prophylaxis of MAC in which rifabutin was ...

https://www.cdc.gov/mmwr/preview/mmwrhtml/00032508.htm

Uveitis is swelling and inflammation of the uvea. The uvea is the middle layer of the wall of the eye. The uvea supplies blood ... Treatment of uveitis. eyewiki.aao.org/Treatment_of_Uveitis. Updated September 18, 2022. Accessed October 27, 2022. ... Uveitis is swelling and inflammation of the uvea. The uvea is the middle layer of the wall of the eye. The uvea supplies blood ... If the uveitis is caused by a body-wide (systemic) infection, you may be given antibiotics. You may also be given powerful anti ...

https://medlineplus.gov/ency/article/001005.htm

JavaScript is disabled for your browser. Some features of this site may not work without it ...

https://apps.who.int/iris/browse?authority=Uveitis&type=mesh

Uveitis is defined as inflammation of the uveal tract,the anatomy of which includes the iris, ciliary body, and choroid. See ... Causes of uveitis in the general practice of ophthalmology. UCLA Community-Based Uveitis Study Group. Am J Ophthalmol. 1996 Jan ... Uveitis, particularly posterior uveitis, is a common cause of preventable blindness, so it is deemed a sight-threatening ... Generally, the prognosis for iritis and uveitis is good with appropriate treatment. However, uveitis can be recurrent and ...

https://www.medscape.com/answers/798323-85522/what-is-the-morbidity-associated-with-uveitis

... or anterior uveitis, is the most common form of intraocular inflammation. It is a common cause of a painful red eye. ... Causes of uveitis in the general practice of ophthalmology. UCLA Community-Based Uveitis Study Group. Am J Ophthalmol. 1996 Jan ... In one community-based study, anterior uveitis accounted for more than 90% of all cases of uveitis. The annual incidence rate ... The most common form of nongranulomatous anterior uveitis is acute anterior uveitis (AAU), which is associated with the human ...

http://emedicine.medscape.com/article/1209595

Treatments and Tools for uveitis. Find uveitis information, treatments for uveitis and uveitis symptoms. ... uveitis - MedHelps uveitis Center for Information, Symptoms, Resources, ... Posts on uveitis. Uveitis as initial symptom of ms - Multiple Sclerosis Community ... Have uveitis now, 6 years of Lyme in central nervous system. Most effective treatment was I... ...

https://www.medhelp.org/tags/show/7405/uveitis?section=subjects&page=2

... Indian J Ophthalmol. 2017 Apr;65(4):264-270. doi: 10.4103/ijo.IJO_464_16. ...

https://pubmed.ncbi.nlm.nih.gov/28513488/

CME activities and events that target topics in uveitis. ... Uveitis News. Nov 11, 2022 Week in review: COVID-19 pandemic ... Podcast: Herpetic Uveitis, from Front to Back Dr. Brian Do shares his diagnostic and therapeutic approach to herpetic uveitis, ... Senior Editor, Uveitis. Ashleigh Laurin Levison, MD. Committee Members. Eric L. Crowell, MD, MPH. Alla Goldberg, MD. Olena ... Editorial Board: Uveitis. Editor-in-Chief, the ONE Network. Purnima S. Patel, MD ...

https://www.aao.org/uveitis

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https://extranet.who.int/iris/restricted/browse?authority=Uveitis&type=mesh

Uveitis is a form of eye inflammation that can cause pain, redness and blurry vision. Prompt treatment is important. ... The type of uveitis you have depends on which part or parts of the eye are inflamed:. *Anterior uveitis affects the inside of ... Cigarette smoking has been associated with more difficult to control uveitis.. Complications. Left untreated, uveitis can cause ... Intermediate uveitis affects the retina and blood vessels just behind the lens (pars plana) as well as the gel in the center of ...

https://www.mayoclinic.org/diseases-conditions/uveitis/symptoms-causes/syc-20378734

Uveitis is defined as inflammation of the uveal tract,the anatomy of which includes the iris, ciliary body, and choroid. See ... Causes of uveitis in the general practice of ophthalmology. UCLA Community-Based Uveitis Study Group. Am J Ophthalmol. 1996 Jan ... Uveitis, particularly posterior uveitis, is a common cause of preventable blindness, so it is deemed a sight-threatening ... encoded search term (Iritis and Uveitis) and Iritis and Uveitis What to Read Next on Medscape ...

https://emedicine.medscape.com/article/798323-overview

BACKGROUND/AIMS: Uveitis is inflammation inside the eye. Our objective was to assess the cost-effectiveness of adalimumab ... Adalimumab may be more cost-effective in patients with active uveitis at greater risk of blindness. However, there is an unmet ... 7 more authors) (2019) Adalimumab for non-infectious uveitis: is it cost-effective? British Journal of Ophthalmology, 103 (11 ... 800 775 per QALY for active and inactive uveitis. CONCLUSION: The estimated ICERs of adalimumab versus LCP are above generally ...

https://eprints.whiterose.ac.uk/142661/

... , Medication Causes of Iritis, Drug-Induced Uveitis, Drug-Induced Iritis. ... Medication Causes of Uveitis. Aka: Medication Causes of Uveitis, Medication Causes of Iritis, Drug-Induced Uveitis, Drug- ...

https://fpnotebook.com/legacy/Eye/Pharm/MdctnCsOfUvts.htm

The American Uveitis Society is a 501(c)6 non-profit organization. ...

https://uveitissociety.org/Sitemap

Uveitis is a retinal disorder that affects the middle layer of tissue in the eye wall. It is a rare disease of the nervous ...

https://www.panfoundation.org/disease-funds/uveitis/

Uveitis. Uveitis, Anterior. Iridocyclitis. Ocular Hypertension. Eye Diseases. Uveal Diseases. Panuveitis. Iris Diseases. ... but can also be caused as a side effect of the corticosteroids used to treat uveitis. The raised IOP in uveitis is more ... Aqueous Humor Dynamics and Hypertensive Uveitis. The safety and scientific validity of this study is the responsibility of the ... Uveitis is a disease that affects over 2 million people around the globe, and can ultimately lead to blindness. The proportion ...

https://www.clinicaltrials.gov/show/NCT02765308

Adalimumab Maintains Remission of Childhood Uveitis. Compared with infliximab, adalimumab treatment more effective at delaying ... However, treatment with adalimumab showed an increased likelihood of uveitis remission. At 40 months of follow-up, 60 percent ... MONDAY, April 18 (HealthDay News) -- Children with noninfectious childhood uveitis are more likely to remain in remission when ... adalimumab is more efficacious than infliximab in maintaining remission of chronic childhood uveitis, the authors write. ...

https://consumer.healthday.com/rheumatology-18/misc-kid-s-health-news-435/adalimumab-maintains-remission-of-childhood-uveitis-651576.html

Patients with diffuse uveitis and inactive toxoplasmic retinitis lesions test PCR positive for Toxoplasma gondii in their ... Patients with diffuse uveitis and inactive toxoplasmic retinitis lesions test PCR positive for Toxoplasma gondii in their ...

https://bjo.bmj.com/content/98/7/937.altmetrics

Posterior Uveitis, and Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment (MUST) Trial and ... "Uveitis, Posterior" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Uveitis, Posterior" by people in Harvard Catalyst Profiles by ... The Great Imitator: Ocular Syphilis Presenting as Posterior Uveitis. Am J Case Rep. 2015 Jul 07; 16:434-7. ...

https://connects.catalyst.harvard.edu/Profiles/display/Concept/Uveitis,%20Posterior

Merck & Co., Inc., Rahway, NJ, USA (known as MSD outside of the US and Canada) is dedicated to using the power of leading-edge science to save and improve lives around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Vet Manual outside of North America.. ...

https://www.merckvetmanual.com/multimedia/table/equine-recurrent-uveitis

Among all causes of uveitis, the mean age of onset is clearly younger in patients with intermediate uveitis, 30.7 years (+ 15.1 ... The Pars Planitis Online Support Group is an ongoing project of the Ocular Immunology and Uveitis Foundation and the Uveitis/ ... Pars planitis is one form of intermediate uveitis, and some physicians may use this term, "intermediate uveitis," to describe ... Lit search: Pediatric uveitis. Immunomodulatory Therapy for Treatment of Autoimmune Uveitis. *Review article: Immunosuppressive ...

https://uveitis.org/patients/support/parsplantis-org/

There is no known cure for uveitis, a disease that, according to the American Uveitis Society, is newly diagnosed in ... Uveitis, an inflammatory disease of the eye, is the third leading cause of blindness in the US, after diabetes and macular ... Autoimmune uveitis is believed to result from an autoimmune reaction to antigens in the eye, specifically the S-antigen and the ... While there are steps that can be taken to preserve sight and slow the progress of vision loss, individuals with uveitis are ...

https://www.enzo.com/therapeutics/therapeutic-market/uveitis

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...

https://bjo.bmj.com/content/83/12/1403.1.info

... according to results from the Multicenter Uveitis Steroid Treatment (MUST) trial as presented by Jennifer E. Thorne, MD, PhD, ... Both systemic and localized treatment for vision-threatening uveitis are effective in improving visual acuity and controlling ... "Secondary outcomes included: control of uveitis, development of or prevention of complications in the eye related to uveitis, ... Uveitis is estimated to be the fifth to sixth leading cause of blindness in this country, with onset in all age groups. The ...

https://www.ophthalmologytimes.com/view/systemic-localized-treatment-both-effective-uveitis

Of 57 eyes, 31 (54.39%) had anterior uveitis, 12 (21.05%) had intermediate uveitis, nine (15.79%) had posterior uveitis, and ... undifferentiated intermediate uveitis (15.38%), HLA-B27-associated anterior uveitis (7.69%), and herpetic anterior uveitis ( ... The leading diagnoses were traumatic uveitis (25.64%), undifferentiated anterior uveitis (17.95%), ... Mean BCVA improved during follow-up in all but the anterior uveitis group. The mean baseline intraocular pressure was 14.27 ...

https://www.dovepress.com/causes-of-uveitis-in-children-without-juvenile-idiopathic-arthritis-peer-reviewed-fulltext-article-OPTH

Anterior uveitis involves inflammation of the iris and ciliary body. Intermediate uveitis involves the posterior ciliary body ... Uveitis is a broad term for inflammation of one or all parts of the uvea, or the vascular area between the retina and sclera of ... Uveitis can be acute, recurrent, or chronic. Acute uveitis is characterised by sudden onset (over hours or days) and limited ... Anterior uveitis involves inflammation of the iris and ciliary body. Intermediate uveitis involves the posterior ciliary body ...

https://bestpractice.bmj.com/topics/en-gb/407

Uveitis. Uveitis, Anterior. Iridocyclitis. Uveal Diseases. Eye Diseases. Panuveitis. Iris Diseases. Pharmaceutical Solutions. ... Active intermediate or posterior uveitis in the study eye(s).. *Previous anterior uveitis episode in the study eye ≤ 4 weeks ... Non-infectious Anterior Uveitis Drug: ADX-102 Ophthalmic Solution (0.5%) Drug: Vehicle of ADX-102 Ophthalmic Solution Phase 3 ... SOLACE Trial - A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis.. The safety and scientific validity of this ...

https://clinicaltrials.gov/ct2/show/NCT03131154?term=NCT03131154&rank=1

... in the equine recurrent Uveitis Equine Recurrent Uveitis (ERU) is a wide spread disease of the eye, which is the main cause for ... in the equine recurrent Uveitis Equine Recurrent Uveitis (ERU) is a wide spread disease of the eye, which is the main cause for ... bei der equinen rezidivierenden Uveitis Die equine rezidivierende Uveitis (ERU) ist eine weit verbreitete Augenerkrankung, die ... bei der equinen rezidivierenden Uveitis Die equine rezidivierende Uveitis (ERU) ist eine weit verbreitete Augenerkrankung, die ...

https://edoc.ub.uni-muenchen.de/3615/

The aim of this study was to assess the clinical features of uveitis with biopsy-prov ... isolated posterior uveitis in 8 patients (13.3%), intermediate and posterior uveitis (i.e. anterior uveitis sparing) in 16 ... Uveitis with Biopsy-proven Sarcoidosis in Chinese-A Study of 60 Patients in a Uveitis Clinic Over a Period of 20 Years. Chung, ... Uveitis with Biopsy-proven Sarcoidosis in Chinese-A Study of 60 Patients in a Uveitis Clinic Over a Period of 20 Years ...

https://journals.lww.com/jcma/Abstract/2007/11000/Uveitis_with_Biopsy_proven_Sarcoidosis_in.5.aspx

Iritis and irido-cyclitis (anterior uveitis) are most often mild. (medlineplus.gov)
With proper treatment, most attacks of anterior uveitis go away in a few days to weeks. (medlineplus.gov)
Uveitis is defined as inflammation of the uveal tract, which is further subdivided into anterior and posterior components. (medscape.com)
Chronic anterior uveitis presents primarily as blurred vision and mild redness. (medscape.com)
Iritis, or anterior uveitis, is the most common form of intraocular inflammation. (medscape.com)
The most common form of nongranulomatous anterior uveitis is acute anterior uveitis (AAU), which is associated with the human leukocyte antigen (HLA)-B27 allele in one half to two thirds of cases. (medscape.com)
However, only 1% of people who carry the HLA-B27 allele develop acute anterior uveitis. (medscape.com)
In the case of HLA-B27-associated acute anterior uveitis, speculation about molecular mimicry has unsubstantiated in humans. (medscape.com)
In one community-based study, anterior uveitis accounted for more than 90% of all cases of uveitis. (medscape.com)
Episodes of acute anterior uveitis are often associated with pain, photophobia, decreased vision, and the need for follow-up visits, all of which affect quality of life. (medscape.com)
HLA-B27-associated anterior uveitis is more common in whites. (medscape.com)
Wakefield D, Chang JH, Amjadi S, Maconochie Z, Abu El-Asrar A, McCluskey P. What is new HLA-B27 acute anterior uveitis? (medscape.com)
Anterior uveitis affects the inside of the front of your eye (between the cornea and the iris) and the ciliary body. (mayoclinic.org)
The investigators propose to undertake a cross-sectional observational study of patients with recurrent idiopathic acute anterior uveitis, to determine the relative contributions of altered aqueous production and drainage to the development of raised IOP in these patients. (clinicaltrials.gov)
Of 57 eyes, 31 (54.39%) had anterior uveitis, 12 (21.05%) had intermediate uveitis, nine (15.79%) had posterior uveitis, and five (8.77%) had panuveitis. (dovepress.com)
Mean BCVA improved during follow-up in all but the anterior uveitis group. (dovepress.com)
Anterior uveitis involves inflammation of the iris and ciliary body. (bmj.com)
Acute anterior uveitis may be idiopathic, or associated with human leukocyte antigen-B27-related disease or viral eye disease. (bmj.com)
Topical corticosteroids are usually adequate for acute non-infectious anterior uveitis, but intermediate and posterior uveitis usually requires injected local corticosteroids or systemic corticosteroids, or other immunosuppression. (bmj.com)
an irritation of this segment, or anterior uveitis, leads to acute painful symptoms and photophobia. (bmj.com)
A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis. (clinicaltrials.gov)
A Phase 3, randomized, double-masked, vehicle-controlled trial to evaluate the safety and efficacy of ADX-102 ophthalmic solution in Subjects with non-infectious anterior-uveitis. (clinicaltrials.gov)
Efficacy of ADX-102 on anterior chamber cell count using an anterior uveitis grading scale. (clinicaltrials.gov)
Evaluate the efficacy of ADX-102 Ophthalmic Solution on anterior chamber cell count in subjects with non-infectious anterior uveitis. (clinicaltrials.gov)
Subjects with acute non-infectious anterior uveitis with onset of symptoms within the previous 2 weeks. (clinicaltrials.gov)
Previous anterior uveitis episode in the study eye ≤ 4 weeks prior to screening. (clinicaltrials.gov)
Market Strides, a leading global market research firm, is pleased to announce its new report on Anterior Uveitis Market, forecast for 2022-2030, covering all aspects of the market and providing up-to-date data on current trends. (goerieblogs.com)
Anterior Uveitis Market research report can help you in taking the right business decisions. (goerieblogs.com)
According to a review of the study in Ophthalmology Times, "Five of seven patients had bilateral non-granulomatous anterior uveitis-four with chronic and one with recurrent disease. (ocli.net)
Pediatric non-infectious anterior uveitis is the most common systemic illness in children with juvenile idiopathic arthritis (JIA). (the-rheumatologist.org)
Non-infectious uveitis accounts for more than 75% of cases of pediatric anterior uveitis. (the-rheumatologist.org)
To enroll in the study, children had to be at least 2-years-old, have active JIA-associated non-infectious anterior uveitis and be refractory to at least 12 weeks of methotrexate therapy. (the-rheumatologist.org)
These results show that adalimumab has the potential to help children preserve their eyesight from the ocular complications that occur with chronic non-infectious anterior uveitis. (the-rheumatologist.org)
The commonest form of uveitis seen in association with JIA is chronic anterior uveitis, which is almost always asymptomatic in the initial stages. (bris.ac.uk)
Anterior uveitis is the most common form of uveitis constituting 75% of all cases of uveitis with annual incidence, 12 per 100,000. (financedigest.com)
Further reduction of immunosuppressive treatment, causing a rapid increase in CD4-T lymphocyte count, was associated in the same eye with the occurrence of IRU consisting of anterior uveitis, vitritis, and macular edema. (elsevier.com)
2 The broad disease entity of uveitis can be further classified into the anatomical divisions of anterior, intermediate, posterior, and panuveitis. (touchophthalmology.com)
2 Anterior uveitis primarily affects the iris, ciliary body, cornea, or sclera, and usually has a non-infectious-and often idiopathic-etiology. (touchophthalmology.com)
1 Overall, anterior uveitis is the most common form, representing 28-61% of all cases. (touchophthalmology.com)
2 Intermediate uveitis affects the anterior vitreous and pars plana, causing floaters and vision loss from cystoid macular edema. (touchophthalmology.com)
Topical steroid drops and ointment are primarily useful for anterior uveitis or as adjunct therapy along with systemic treatment for panuveitis, as penetration into the posterior segment is minimal. (touchophthalmology.com)
We report a case of oleander -associated keratitis with subsequent corneal edema and anterior uveitis . (bvsalud.org)
Despite treatment with topical moxifloxacin , she developed severe corneal edema and anterior uveitis . (bvsalud.org)
Visual acuity , anterior uveitis , and corneal edema significantly improved with aggressive immunomodulation . (bvsalud.org)
Follow-up at 1 month confirmed complete recovery of symptoms, corneal edema and anterior uveitis . (bvsalud.org)
Severe corneal edema and anterior uveitis can be associated with oleander exposure. (bvsalud.org)
Association of T-Bet, GATA-3, RORC, and FOXP3 Copy Number Variations With Acute Anterior Uveitis With or Without Ankylosing Spondylitis in Chinese Han. (cdc.gov)

The most common form of uveitis involves inflammation of the iris, in the front part of the eye. (medlineplus.gov)
Another form of uveitis is pars planitis. (medlineplus.gov)
Iritis is the most frequent form of uveitis encountered by ophthalmologists. (medscape.com)
Pars planitis is a form of uveitis, one of a diverse group of potentially blinding but treatable inflammatory eye disorders affecting the middle layer of the eye know as the uvea or uveal tract . (uveitis.org)
The most common form of uveitis has no symptoms ('silent uveitis'), which is why regular eye check ups are essential. (arthritisnsw.org.au)
2 This form of uveitis accounts for more visual loss than other forms, often due to cystoid macular edema, retinal detachment, cataract, glaucoma, subretinal fibrosis, and optic disc atrophy. (touchophthalmology.com)

The raised IOP in uveitis is more difficult to treat than other types of glaucoma. (clinicaltrials.gov)
Patient Selection All subjects attending the uveitis and glaucoma clinics at St Thomas' Hospital will be eligible to be included in the study if they fulfil the inclusion/exclusion criteria as below. (clinicaltrials.gov)
While there are steps that can be taken to preserve sight and slow the progress of vision loss, individuals with uveitis are also at increased risks of developing cataracts, glaucoma, or retinal detachment. (enzo.com)
Uveitis is a debilitating disease that can lead to cataracts, glaucoma, macular edema and blindness. (the-rheumatologist.org)
The sight-threatening complications of JIA-associated uveitis include cataracts, glaucoma, band keratopathy, and macular oedema. (bris.ac.uk)
Endogenous causes of cataracts include: uveitis, retinal degeneration (PRA), and glaucoma. (vin.com)
Dogs that exhibit pre-existent keratitis, keratoconjunctivitis sicca, uveitis, glaucoma, and retinal degeneration are usually poor surgical candidates. (vin.com)
Outcomes of Kahook Dual Blade Goniotomy for Uveitis Associated Open Angle Glaucoma or Ocular Hypertension. (cuanschutz.edu)
Hydrus Microstent malposition with uveitis-glaucoma-hyphema syndrome. (cuanschutz.edu)

It is also called iritis and is the most common type of uveitis. (mayoclinic.org)

Causes of uveitis in the general practice of ophthalmology. (medscape.com)
Nov 11, 2022 Week in review: COVID-19 pandemic slows research, rising AMD rates, multidisciplinary care for uveitis The pandemic has negatively impacted ophthalmology research, AMD rates are rising in the United States, combined ophthalmologist-rheumatologist visits help patients with uveitis, and Case Western Reserve University has received a large NEI grant for neural eye research. (aao.org)
Both systemic and localized treatment for vision-threatening uveitis are effective in improving visual acuity and controlling uveitis and macular edema, according to results from the Multicenter Uveitis Steroid Treatment (MUST) trial as presented by Jennifer E. Thorne, MD, PhD, here at the 24th annual Current Concepts in Ophthalmology meeting. (ophthalmologytimes.com)
This latest Pharmaceutical and Healthcare disease pipeline guide Uveitis - Drugs In Development, 2022, provides an overview of the Uveitis (Ophthalmology) pipeline landscape. (reportlinker.com)
Pharmaceutical and Healthcare latest pipeline guide Uveitis - Drugs In Development, 2022, provides comprehensive information on the therapeutics under development for Uveitis (Ophthalmology), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (reportlinker.com)
The Uveitis (Ophthalmology) pipeline guide also reviews of key players involved in therapeutic development for Uveitis and features dormant and discontinued projects. (reportlinker.com)
Uveitis (Ophthalmology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. (reportlinker.com)
The pipeline guide provides a snapshot of the global therapeutic landscape of Uveitis (Ophthalmology). (reportlinker.com)
The pipeline guide reviews pipeline therapeutics for Uveitis (Ophthalmology) by companies and universities/research institutes based on information derived from company and industry-specific sources. (reportlinker.com)
The pipeline guide reviews key companies involved in Uveitis (Ophthalmology) therapeutics and enlists all their major and minor projects. (reportlinker.com)
The pipeline guide evaluates Uveitis (Ophthalmology) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. (reportlinker.com)
Find and recognize significant and varied types of therapeutics under development for Uveitis (Ophthalmology). (reportlinker.com)
Formulate corrective measures for pipeline projects by understanding Uveitis (Ophthalmology) pipeline depth and focus of Indication therapeutics. (reportlinker.com)
According to the report, the uveitis treatment market is estimated to grow by ~6% CAGR in 2029, primarily attributed to rising R&D activities in the field of ophthalmology, increasing number of clinical trials for eye inflammation disorders treatment, increase in the investment in molecular biology, growing cases of infectious diseases, and increase in prevalence of uveitis. (financedigest.com)

Recorded in front of a live audience at the AAO 2022 Annual Meeting in Chicago, this episode features an interview with Dr. Nisha Acharya about her recent article on COVID-19 and noninfectious uveitis. (aao.org)
Jun 17, 2022 Small increase in noninfectious uveitis seen after BNT162b2 COVID-19 vaccination Investigators studied the rates of noninfectious uveitis (NIU) in people who received the initial doses of the BNT162b2 COVID-19 vaccine and compared them with historic NIU rates. (aao.org)

If the uveitis is caused by a body-wide (systemic) infection, you may be given antibiotics. (medlineplus.gov)
If you have a body-wide (systemic) infection or disease, treating the condition may prevent uveitis. (medlineplus.gov)
Benefits of Systemic Anti-inflammatory Therapy versus Fluocinolone Acetonide Intraocular Implant for Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study. (harvard.edu)
Secondary outcomes included: control of uveitis, development of or prevention of complications in the eye related to uveitis, ocular and systemic side effects associated with treatment, and quality of life measures. (ophthalmologytimes.com)
Residual active uveitis remained in 12% of those in the implant therapy group and 29% of those in the systemic therapy group ( p = 0.001). (ophthalmologytimes.com)
At 2 years, there was a 66% reduction in the level of uveitis activity in the group with the implants and a 46% reduction in the systemic group, and this was statistically significant ( p = 0.001). (ophthalmologytimes.com)
Control of active uveitis occurred more quickly and more frequently in the implant group than in the systemic arm, although there was an impressive improvement with both therapies," Dr. Thorne said. (ophthalmologytimes.com)
Uveitis describes a heterogeneous group of inflammatory diseases of the eye representing both systemic immune-mediated and infectious processes as well as inflammatory processes localized to the eye. (dovepress.com)
Posterior uveitis is associated with localised infections or systemic infection, or systemic inflammatory disease. (bmj.com)
Treatment for systemic disease causing uveitis must be given in conjunction with uveitis therapy. (bmj.com)
Uveitis has many causes including infection , trauma or injury to the eye , autoimmune diseases , other systemic diseases. (healthtap.com)
3 Many patients with posterior uveitis or panuveitis depend on systemic steroids to achieve longterm control of intraocular inflammation. (touchophthalmology.com)
Diagnostic testing to identify major systemic diseases associated with uveitis. (medscape.com)
By definition, Behçet disease is accompanied by other findings, including genital ulcers, uveitis, and other skin and systemic inflammatory processes. (logicalimages.com)

METHODS: In this retrospective study, EDI-OCT scans of patients with idiopathic posterior uveitis or panuveitis were reviewed. (ucl.ac.uk)

Intermediate uveitis involves the posterior ciliary body and pars plana. (bmj.com)
Uveitis is an inflammatory eye disease affecting the iris, ciliary body, and choroid that can lead to symptoms ranging from redness, pain, and blurred vision to markedly diminished acuity in the setting of severe or chronic disease. (touchophthalmology.com)

This type of uveitis is called choroiditis. (medlineplus.gov)
Patients were stratified based upon the type of uveitis they had and by the clinical site where they were enrolled. (ophthalmologytimes.com)

Physicians are encouraged to report cases of uveitis to the Food and Drug Administration's MedWatch Program, telephone (800) 332-1088 ({301} 738-7553). (cdc.gov)

Intermediate uveitis affects the retina and blood vessels just behind the lens (pars plana) as well as the gel in the center of the eye (vitreous). (mayoclinic.org)
The most important characteristics of posterior uveitis are vitreous opacities, choroiditis, and chorioretinitis. (harvard.edu)
There are many different types of uveitis, depending on the area of uvea that's affected, but they all lead to the same thing: inflammation of your vitreous, the jelly-like substance in the middle of your eye. (paceyemd.com)
If your uveitis doesn't respond to these more conservative treatments, your doctor may recommend a more aggressive approach to safeguard your vision, including a vitrectomy to remove some of your vitreous. (paceyemd.com)

Section 9 of the BCSC covers diagnosis, management of uveitis, scleritis and ocular inflammation. (aao.org)

Infectious & Not-Infectious Uveitis treatment and Ocular Inflammation. (atozholidaymedicare.net)

This is likely to occur for reasons related to the uveitis itself, but can also be caused as a side effect of the corticosteroids used to treat uveitis. (clinicaltrials.gov)
Given the findings, Dr. Ostheimer and other physicians agree that it may be beneficial for eye doctors who treat uveitis should consider asking patients about any tattoo changes they may also be experiencing, as a component of the ink may be acting as an environmental trigger. (ocli.net)
Eye doctors treat uveitis with corticosteroid drops, pills, and injections to reduce spasms or suppress the immune system. (vision-boston.com)

Adalimumab may be more cost-effective in patients with active uveitis at greater risk of blindness. (whiterose.ac.uk)
Children with active uveitis may need to be seen much more often by an ophthalmologist but your child's doctor will direct this plan. (arthritisnsw.org.au)

MONDAY, April 18 (HealthDay News) -- Children with noninfectious childhood uveitis are more likely to remain in remission when treated with adalimumab compared to infliximab, according to a study published in the April issue of Arthritis Care & Research . (healthday.com)
Even if limited to a relatively small group, our study suggests that over three years of treatment, adalimumab is more efficacious than infliximab in maintaining remission of chronic childhood uveitis,' the authors write. (healthday.com)
4 , 5 Furthermore, the scope of possible etiologies of childhood uveitis is quite vast and often differs from that in the adult population. (dovepress.com)

A close relationship between asymptomatic (subclinical) ileocolitis has been demonstrated in patients with recurrent uveitis. (medscape.com)
In recurrent uveitis, there are repeated episodes separated by disease inactivity ≥3 months, whether on or off treatment. (bmj.com)
Characterisation of the autoantigen "mitochondrial malate dehydrogenase" in the equine recurrent Uveitis Equine Recurrent Uveitis (ERU) is a wide spread disease of the eye, which is the main cause for blindness in horses worldwide. (uni-muenchen.de)
Moon Blindness in Horses - What is Equine Recurrent Uveitis? (horsejournals.com)
Equine recurrent uveitis (ERU), also known as moon blindness, is the most common cause of blindness in horses worldwide. (horsejournals.com)
Equine recurrent uveitis is hypothesized to be a complex autoimmune disease influenced by both genetic and environmental factors. (horsejournals.com)
Equine recurrent uveitis can affect one eye or both eyes, and may cause more severe signs in one eye than the other. (horsejournals.com)
Equine recurrent uveitis (ERU) is an important ophthalmic condition, with a reported prevalence of 2%-25% worldwide . (msdvetmanual.com)
Equine recurrent uveitis is an autoimmune syndrome that ensues after an initial episode of acute uveitis . (msdvetmanual.com)
Clinical findings associated with equine recurrent uveitis include acute signs of active inflammation as well as chronic secondary complications. (msdvetmanual.com)
Horses with equine recurrent uveitis (ERU) received episcleral or deep scleral lamellar CsA implants and were monitored for up to 3 years. (emmes.com)
61-year-old Penny Maitra benefited from CUES earlier this year after a flare up of recurrent Uveitis (inflammation of the iris). (mft.nhs.uk)

Sometimes certain types of immune-suppressant drugs are used to treat severe uveitis. (medlineplus.gov)
Some previous studies report an increase in severe vision loss in children with uveitis compared to adult patients, 6 - 8 a finding that has long-term implications for quality of life and future productivity. (dovepress.com)
If the eye drops don't control the uveitis or the uveitis is severe, your child may require other medicines by mouth or injection. (arthritisnsw.org.au)
Some children who develop complications of severe uveitis may require eye surgery to improve their vision and protect their eyes. (arthritisnsw.org.au)
Severe vision loss is estimated to occur in 25-30% of pediatric uveitis cases, making early diagnosis and treatment necessary to protecting vision. (the-rheumatologist.org)
In the context of eyes with moderate to severe uveitis for years, this rate is not unexpected. (northwestern.edu)
Tacrolimus is also can be recommended in the treatment of other T cell-mediated diseases such as eczema and psoriasis (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after the transplant of bone marrow, Kimura's disease, skin condition vitiligo and exacerbations of minimal change disease. (ikrispharmanetwork.com)

Posterior segment uveitis is a high unmet need area with limited treatment options and the third leading cause of blindness in the U.S. If approved, pSivida expects to launch Durasert in the U.S. in the first half of 2019. (mtspartners.com)
En décembre 2019, la population de Wuhan, une grande ville chinoise de 11 millions d'habitants, est atteinte par une pneumonie virale extrêmement contagieuse due au coronavirus SARSCoV-2. (bvsalud.org)

Purpose: To describe fluocinolone acetonide implant dissociations in the Multicenter Uveitis Steroid Treatment (MUST) Trial. (northwestern.edu)

Current therapies reduced the uveitis recurrences and ocular complications including cataract due also to the lower use of corticosteroids. (researchsquare.com)
The corticosteroids market is increasing a great deal of footing in the treatment landscape, as it has been the primary choice of medication for uveitis treatment by ophthalmologists. (financedigest.com)
According to the report, in 2018 corticosteroids, monoclonal antibodies, and antibiotics constitute more than 50% of the total market revenue in the uveitis treatment market. (financedigest.com)
The mainstay of non-infectious uveitis treatment is corticosteroids, which are administered in three forms: topically, locally via sub-Tenon's or intravitreal injection, and systemically. (touchophthalmology.com)

Durand ML. Infectious causes of uveitis. (medlineplus.gov)
Adalimumab for non-infectious uveitis: is it cost-effective? (whiterose.ac.uk)
Recent advances in the management of non-infectious posterior uveitis. (harvard.edu)
Clinical features of infectious posterior segment uveitis. (harvard.edu)
Locally administered (subconjunctival or intravitreal) sirolimus appears to be safe in patients with non-infectious uveitis. (arvojournals.org)
The antibiotics treatment type segment is expected to be the fastest growing segment in the uveitis treatment market during the forecast period, owing to rise in infectious ocular disorders globally. (financedigest.com)
3 Posterior uveitis is often infectious, with toxoplasmosis and cytomegalovirus representing 24.6 and 11.6% of cases, respectively. (touchophthalmology.com)
Toxoplasmosis is the most common cause of infectious posterior uveitis in adults and children. (aao.org)
The Company will use these resources to finance the Icon acquisition and prepare for the commercial launches of DEXYCU and, if approved by FDA, Durasert™ micro-insert for the treatment of non-infectious uveitis affecting the posterior segment of the eye. (mtspartners.com)
On March 19, 2018, the FDA accepted pSivida's NDA for Durasert micro-insert for treatment of non-infectious posterior segment uveitis, which will be subject to a standard review and has a Prescription Drug User Fee Act (PDUFA) action date of November 5, 2018. (mtspartners.com)

Opacities of the lens (cataracts) may be present but are not specific for uveitis. (medscape.com)

The purpose of this study was to report the demographics, disease characteristics, treatments, and visual outcomes of pediatric uveitis patients without juvenile idiopathic arthritis managed in a tertiary medical center. (dovepress.com)
A retrospective, observational study was performed in pediatric uveitis patients without juvenile idiopathic arthritis and aged 0-18 years, who were seen at the University of Virginia from 1984 to 2014. (dovepress.com)
Uveitis of all types affects children and adults, and the aetiology is most commonly idiopathic. (bmj.com)
Uveitis is the most common eye problem associated with juvenile idiopathic arthritis (JIA). (arthritisnsw.org.au)
Juvenile idiopathic arthritis (JIA) is the commonest rheumatic disease in children and JIA-associated uveitis its most frequent extra-articular manifestation. (bris.ac.uk)
To describe the ophthalmological characteristics in a Juvenile idiopathic arthritis (JIA) cohort and to evaluate how therapeutic advances have changed the course of the uveitis. (researchsquare.com)

The patients who had the most to gain-those whose vision was 20/40 or worse-tended to be the ones who had the most improvement, likely because of the control of the uveitis and the resolution of macular edema. (ophthalmologytimes.com)

Charakterisierung des Autoantigens „mitochondriale Malat-Dehydrogenase" bei der equinen rezidivierenden Uveitis Die equine rezidivierende Uveitis (ERU) ist eine weit verbreitete Augenerkrankung, die weltweit die Hauptursache für das Erblinden von Pferden darstellt. (uni-muenchen.de)

Possible causes of uveitis are infection, injury, or an autoimmune or inflammatory disease. (mayoclinic.org)
In about half of all cases, the specific cause of uveitis isn't clear, and the disorder may be considered an autoimmune disease that only affects the eye or eyes. (mayoclinic.org)
Intraocular pressures were 20 mm Hg in the cate management of Ebola virus disease-related uveitis right eye and 8 mm Hg in the left eye. (cdc.gov)
Uveitis is a disease that affects over 2 million people around the globe, and can ultimately lead to blindness. (clinicaltrials.gov)
We recommend that patients with pars planitis (intermediate uveitis), an inflammatory eye disease, establish a relationship with a uveitis specialist and consult with that physician before making any healthcare decisions. (uveitis.org)
Uveitis, an inflammatory disease of the eye, is the third leading cause of blindness in the US, after diabetes and macular degeneration. (enzo.com)
There is no known cure for uveitis, a disease that, according to the American Uveitis Society, is newly diagnosed in approximately 38.000 people every year. (enzo.com)
Because of the high burden of disease, the difficulty of making precise etiologic diagnoses, and the complicated management, it is imperative that affected children be referred to and closely monitored by uveitis specialists to prevent devastating ocular damage. (dovepress.com)
Histological analysis of the eyes 30 days after immunisation revealed that ten out of 14 rats (71%), developed uveitis, whereas non of the six control rats showed signals of the disease. (uni-muenchen.de)
Although not all horses that experience a single episode of uveitis will develop ERU, they are at risk for disease. (horsejournals.com)
CONCLUSIONS: The index study reports qualitative OCT-derived parameters as possible tools in monitoring disease progression in uveitis. (ucl.ac.uk)
Uveitis is a very serious vision condition which can lead to permanent vision loss if not treated, which is why early diagnosis and treatment of this disease are so important to preventing the complications of uveitis. (ocli.net)
While the development of uveitis is often associated with infections, injuries or autoimmune disorders (though the exact cause is often unknown), new literature suggests that tattoo-associated uveitis may actually be a common cause of this disease as well. (ocli.net)
While these studies show that there certainly is some kind of link between black tattoo ink and uveitis, researchers are still slow to say for sure that ink may actually lead to the formation of this eye inflammation disease . (ocli.net)
Survivors of Ebola virus disease (EVD) in Liberia had a higher prevalence of certain health issues - including uveitis (eye redness and pain), abdominal, chest, neurologic, and musculoskeletal abnormalities upon physical exam - when compared to a control group of household and community members who did not have a history of EVD, according to findings from an ongoing study published in the New England Journal of Medicine. (kff.org)

Uveitis is swelling and inflammation of the uvea . (medlineplus.gov)
Uveitis is a broad term for inflammation of one or all parts of the uvea, or the vascular area between the retina and sclera of the eye. (bmj.com)
Uveitis is swelling and irritation of the uvea, the middle layer of the eye. (reportlinker.com)
One hazardous eye condition that can cause serious discomfort and vision loss is uveitis―the inflammation of the uvea, which is the middle layer of the eye. (ocli.net)
In the simplest of terms, uveitis is an inflammation in the middle tissue in your eye called the uvea, which is primarily responsible for providing blood flow to your retina. (paceyemd.com)

This study found that BCVA and intraocular pressure did not vary significantly during follow-up, suggesting that close management by an ophthalmologist may prevent adverse visual outcomes, and highlighted the high prevalence of traumatic uveitis in children, which tends to have good visual outcomes. (dovepress.com)
This condition is rare but should be considered when there is a history of intraocular surgery, trauma and other causes of uveitis have been ruled out. (medscape.com)

The posterior segment was the most common localization of uveitis in biopsy-proven sarcoidosis in Chinese. (lww.com)
4 Local injection of long-acting steroids such as triamcinolone results in therapeutic concentrations in the posterior segment, and therefore can be useful for treatment of posterior uveitis in some individuals. (touchophthalmology.com)

After 6 weeks of follow-up, the uveitis resolved with topical and periocular steroid treatment. (elsevier.com)

All types of uveitis are potentially blinding conditions and should be referred to and managed by an experienced ophthalmologist. (bmj.com)

Cite this: Practical Diagnostic Approach to Uveitis - Medscape - Aug 01, 2011. (medscape.com)

Patients should be instructed to report symptoms of uveitis (i.e., pain, redness, and loss of vision) to their physician. (cdc.gov)
What are the symptoms of uveitis? (arthritisnsw.org.au)

declines were frequently associated with complications of uveitis or its treatment. (northwestern.edu)

The uveitides are thought to affect working Americans more frequently than some of the other age-related diseases such as cataract and macular degeneration. (ophthalmologytimes.com)
Inflammation is normally one of the body's protective responses to infection or injury, but in diseases such as uveitis, uncontrolled inflammation can cause damage. (arthritisnsw.org.au)

Uveitis is estimated to be the fifth to sixth leading cause of blindness in this country, with onset in all age groups. (ophthalmologytimes.com)

Female predominance and peak incidence of uveitis onset in the 6th decade of life were found. (lww.com)
With the increasing popularity of tattoos in the general population, the incidence of tattoo-related uveitis may increase. (atlanta2020.com)
A doption of immunotherapy to treat metastatic melanoma, non-small cell lung cancer and several other malignancies has contributed to the increased incidence of immunotherapy-driven noninfectious uveitis (NIU). (retina-specialist.com)

Acute uveitis is characterised by sudden onset (over hours or days) and limited duration (≤3 months' duration). (bmj.com)
The mean age at uveitis onset was 47.7 ± 14.7 years (range, 21-76 years), with no gender difference ( p = 0.913). (lww.com)

We conducted a retrospective analysis of all consecutive pediatric patients with suspected diagnosis of JIA referred to the Department of Pediatrics and to the Department of Sense Organs, Eye Clinic, Uveitis Unit (Policlinico Umberto I, Sapienza University of Rome), from April 2012 to July 2018. (researchsquare.com)
Global revenues of uveitis treatment market reached ~ 567 million in 2018, unveils the new research study by Persistence Market Research (PMR). (financedigest.com)

Thirty-nine pediatric uveitis patients (57 eyes) were identified. (dovepress.com)

Autoimmune uveitis is believed to result from an autoimmune reaction to antigens in the eye, specifically the S-antigen and the interphotoreceptor retinoid-binding protein (IRBP). (enzo.com)
OptiquelT our candidate drug based on Enzo's immune regulation technology platform is a potential therapy for autoimmune uveitis. (enzo.com)
Recent research suggests that autoimmune uveitis is significantly under-diagnosed an under-recognized. (enzo.com)
The Lewis rat is an established animal model for the research of autoimmune Uveitis. (uni-muenchen.de)
Experimental studies show that animals immunized with S-Ag and IRBP develop pinealitis in addition to experimental autoimmune uveitis (EAU). (medscape.com)

A range of factors to consider when patients on cancer treatment present with noninfectious uveitis. (retina-specialist.com)
Noninfectious uveitis secondary to cancer immunotherapy may occur in some patients with metastatic melanoma. (retina-specialist.com)

This was a retrospective study of uveitis patients with biopsy-proven sarcoidosis who consecutively visited the uveitis clinic of Taipei Veterans General Hospital from 1986 to 2005. (lww.com)
Analysis of a retrospective cohort study of consecutive JIA pediatric patients including JIA-associated uveitis (JIA-U) and comparison with a previous study in the same uveitis center assessed before the wide-spread of biological therapy. (researchsquare.com)
Methods: Retrospective, observational study of uveitis patients seen at the University of Virginia from 1984 to 2014. (elsevier.com)

Effects on the eye in endemic typhus include keratoconjunctivitis and uveitis. (haz-map.com)

Anatomy15

Organisms3

Diseases55

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Psychiatry and Psychology1

Phenomena and Processes1

Health Care3

Geographicals1

IL-4 and IL-10 are both required for the induction of oral tolerance. (1/1070)

Pregnancy ameliorates induction and expression of experimental autoimmune uveitis. (2/1070)

Protective effect of the type IV phosphodiesterase inhibitor rolipram in EAU: protection is independent of IL-10-inducing activity. (3/1070)

Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis. (4/1070)

Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. (5/1070)

Iris crystals in chronic uveitis. (6/1070)

Immunopathology of pineal glands from horses with uveitis. (7/1070)

Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial. (8/1070)

Uveitis, Anterior

Uveitis, Posterior

Uveitis, Intermediate

Panuveitis

Aqueous Humor

Iridocyclitis

Uveitis, Suppurative

Tuberculosis, Ocular

Behcet Syndrome

Retinal Vasculitis

Iris

Autoimmune Diseases

Uveomeningoencephalitic Syndrome

Arthritis, Juvenile

HLA-B27 Antigen

Vitreous Body

Toxoplasmosis, Ocular

Rats, Inbred Lew

Arrestin

Ciliary Body

Chorioretinitis

Uvea

Eye Infections, Viral

Retinol-Binding Proteins

Eye Infections

Visual Acuity

Retinitis

Eye Diseases

Sarcoidosis

Eye Proteins

Fluocinolone Acetonide

Choroiditis

Anterior Chamber

Cataract

Retinal Necrosis Syndrome, Acute

Hyphema

Horse Diseases

Pars Planitis

Spondylitis, Ankylosing

Retina

Eye

Disease Models, Animal

Ophthalmia, Sympathetic

Eye Infections, Bacterial

Immunosuppressive Agents

Fluorescein Angiography

Fundus Oculi

Macular Edema

Anti-Inflammatory Agents

Spondylarthritis

Acute Disease

Lens Diseases

Eye Neoplasms

Scleritis

Autoantigens

Glucocorticoids

Ocular Hypotension

Endotoxins

Retrospective Studies

Vitrectomy

Enzyme-Linked Immunosorbent Assay

Leptospirosis

Sierra Leone

Herpes Zoster Ophthalmicus

Prednisolone

Injections, Intraocular

Paracentesis

Spondylarthropathies

Vision Disorders

Lipopolysaccharides

Suppuration

Recurrence

Chronic Disease

Administration, Topical

Cataract Extraction

Iritis

Anterior Eye Segment

Blood-Aqueous Barrier

Eye Infections, Parasitic

Pregnadienes