Uvaria
Annonaceae
Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata. (1/5)
Two new C-benzylated dihydrochalcones, isochamuvaritin (1) and acumitin (2), have been isolated from the African medicinal plant Uvaria acuminata, together with the previously reported benzylbenzoate (3), uvaretin (4), isouvaretin (5), diuvaretin (6), and uvangoletin (7). The structural elucidation of compounds 1 and 2 in spectroscopic studies is described. C-Benzylated dihydrochalcones, especially 1, 2, 4, and 6, showed considerable cytotoxicity toward human promyelocytic leukemia HL-60 cells. (+info)New polyoxygenated cyclohexenes from Uvaria kweichowensis and their antitumour activities. (2/5)
Two new polyoxygenated cyclohexenes, kweichowenol A and B, were isolated from the leaves of Uvaria kweichowensis, and their structures were established on the basis of their spectral data. The two new compounds showed some antitumour activity by MTT assay. (+info)Larvicidal and IGR activity of extract of Tanzanian plants against malaria vector mosquitoes. (3/5)
BACKGROUND & OBJECTIVES: This paper reports the larvicidal activity of seventeen Tanzanian plant species against the malaria vector, Anopheles gambiae s.s. Giles larvae. Some of the plants are used traditionally as sources of insecticidal materials. METHODS: The crude extracts from the leaves, stem and root barks of the investigated plants were obtained by solvent extraction and then bio-assayed following WHO protocols showed LC50 values 10 to 400 ppm after 24 h exposure. The structures were determined on interpretation of spectroscopic data. RESULTS: The most active extracts were those from the stem and root barks of Annona squamosa, Uvaria faulknerae, U. kirkii and Uvariodendron pycnophyllum, all of which had LC50 values between 10 and 100 ppm. Long-term exposure beyond 24 h also showed more susceptibility of the larvae to the extracts. Larvae deformities by forming tail-like structures were observed for the methanol extracts of Tessmannia martiniana var pauloi. INTERPRETATION & CONCLUSION: The results suggest that the investigated plant extracts are promising as larvicides against An. gambiae s.s. Giles mosquitoes and could be useful leads in the search for new and biodegradable plant derived larvicide products. (+info)Synthesis and stereochemical assignment of (+)-chamuvarinin. (4/5)
(+info)Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest. (5/5)
(+info)"Uvaria" is not a term that has a widely accepted medical definition. It is a genus of flowering plants in the family Annonaceae, commonly known as the custard apple family. Some species of Uvaria are used in traditional medicine in various parts of the world, but there is limited scientific evidence to support their effectiveness or safety.
If you have any specific medical concern related to a plant or substance in the Uvaria genus, I would recommend consulting with a healthcare professional for accurate information and guidance.
Annonaceae is a family of flowering plants, also known as custard apple family. It includes several genera and species of tropical trees and shrubs that are native to the Americas, Africa, Asia, and Australia. The plants in this family are characterized by their large, often fragrant flowers and fleshy fruits. Some of the commercially important crops in this family include cherimoya, soursop, custard apple, and pawpaw. Many species of Annonaceae have also been studied for their potential medicinal properties, including the presence of alkaloids with anticancer and anti-malarial activities.
Acetogenins are a type of compound that are produced by certain plants, particularly those in the family Annonaceae. They are known for their potential medicinal properties, including anti-cancer, anti-malarial, and insecticidal activities. Acetogenins have a complex structure, consisting of a long chain of carbon atoms with various functional groups attached. They work by inhibiting the function of certain enzymes that are necessary for the survival of cancer cells and other target organisms.