Tumors or cancer of the UTERUS.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Neoplasms containing cyst-like formations or producing mucin or serum.
Tumors or cancer of the SKIN.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancers of the KIDNEY.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the THYROID GLAND.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
DNA present in neoplastic tissue.
Tumors or cancer of the LUNG.
Tumors or cancer of the PAROTID GLAND.
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.
Tumors or cancer of the APPENDIX.
Tumors or cancer of the LIVER.
A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Tumors or cancer of the ENDOCRINE GLANDS.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.
Tumors or cancer of the EYE.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the NOSE.
Tumors or cancer of the SALIVARY GLANDS.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
A benign epithelial tumor with a glandular organization.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the INTESTINES.
Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.
A general term for various neoplastic diseases of the lymphoid tissue.
Tumors or cancer located in bone tissue or specific BONES.
Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.
Neoplasms composed of more than one type of neoplastic tissue.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumors or cancer of the MANDIBLE.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Tumors or cancer of the BILE DUCTS.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the THYMUS GLAND.
Tumors or cancer of the SPLEEN.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)
Tumors or cancer of the COLON.
Cancer or tumors of the MAXILLA or upper jaw.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Tumors or cancer of the anal gland.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
Tumors or cancer of the DUODENUM.
Tumors or cancers of the ADRENAL CORTEX.
Tumors or cancer of the MOUTH.
Tumors or cancer of the MEDIASTINUM.
Tumors or cancer of the TONGUE.
Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).
Tumors or cancer of the STOMACH.
Tumors or cancer of the URINARY BLADDER.
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Tumors or cancer of the VAGINA.
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.
Experimentally induced tumors of the LIVER.
A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A malignant epithelial tumor with a glandular organization.
Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE DISORDERS.
Surgical removal of the pancreas. (Dorland, 28th ed)
Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)
Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.
Tumors or cancer of the PARANASAL SINUSES.
Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.
Tumors or cancer of the human BREAST.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
Neoplasms of the bony orbit and contents except the eyeball.
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc.
Tumors or cancer of the BRONCHI.
Tumors or cancer of the PERITONEUM.
Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of MACROPHAGES and DENDRITIC CELLS.
Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.
Neoplasms of the bony part of the skull.
Tumors or cancer of the VULVA.
Neoplasms composed of neuroepithelial cells, which have the capacity to differentiate into NEURONS, oligodendrocytes, and ASTROCYTES. The majority of craniospinal tumors are of neuroepithelial origin. (From Dev Biol 1998 Aug 1;200(1):1-5)
Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).
Tumors or cancer of the LIP.
A benign tumor of fibrous or fully developed connective tissue.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Tumors or cancer of the ADRENAL GLANDS.
Tumors or cancer of the pelvic region.
Tumors or cancer of the gallbladder.
The local implantation of tumor cells by contamination of instruments and surgical equipment during and after surgical resection, resulting in local growth of the cells and tumor formation.
Neoplasms composed of fibrous and epithelial tissue. The concept does not refer to neoplasms located in fibrous tissue or epithelium.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue.
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.
RNA present in neoplastic tissue.
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)
A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
Tumors or cancer of the CECUM.
A malignant disease of the B-LYMPHOCYTES in the bone marrow and/or blood.
A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
Tumors or cancer of the DIGESTIVE SYSTEM.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)
Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
Liquid material found in epithelial-lined closed cavities or sacs.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A benign epithelial tumor of the LIVER.

Coagulation and fibrinolysis in intact hydatidiform molar pregnancy. (1/1969)

Tests of coagulation, fibrinolysis, and platelet function were performed in 17 patients with intact molar pregnancies. Women with intact molar pregnancies had higher fibrinogen factor VIII, and fibrinogen degradation products, concentrations and lower prothrombin, factor X, plasminogen, and plasminogen activator concentrations than controls with normal pregnancies. They also had reduced platelet counts and thromboelastographic values, which indicated hypocoagulability. These results suggest that intravascular coagulation occurs in intact hydatidiform molar pregnancies.  (+info)

The ultrastructure of fibromyomatous myometrium and its relationship to infertility. (2/1969)

The aim of this study was to determine whether the ultrastructure of the non-neoplastic myometrial portion (host myometrium) of fibromyomatous uteri is normal or abnormal when compared to that of fibromyomata and normal myometria. Myometrial samples from 23 normal and 54 fibromyomatous uteri were examined at the ultrastructural level using standard electron microscopy techniques. Ultrastructural abnormalities of certain cellular organelles were noted in myocytes of fibromyomata but not in those of normal or host myometria. The sarcolemmal dense bands of host myometrial myocytes were of significantly greater length than those of normal myometria, but not significantly different to those of fibromyomata. Consequently, the numbers of caveolae in host myometria and fibromyomata are conceivably decreased in comparison to normal myometria. Host myometria can be, therefore, considered to be structurally abnormal. The specific structural abnormality noted may affect calcium metabolism in these tissues by causing a decrease in the cellular calcium extrusion mechanism and thus raising intracellular calcium concentrations. Such an abnormality may provide an answer, in terms of contraction abnormalities, for the unexplained infertility that occurs in a small percentage of symptomatic myomatous patients.  (+info)

Oxytocin and vasopressin receptors in human and uterine myomas during menstrual cycle and early pregnancy. (3/1969)

The purpose of this study was to determine the specificity and concentration of oxytocin (OT) and arginine vasopressin (AVP) binding sites in non-pregnant (NP) human and rhesus monkey endometrium, myometrium and fibromyomas, and to determine the cellular localization of OT receptor (OTR). Besides [3H]AVP, [125I]LVA, a specific VP1 receptor subtype antagonist, was used to determine vasopressin receptor (VPR) concentrations. Samples were obtained from 42 pre-menopausal and three pregnant women (5, 13 and 35 weeks gestation), and several NP and pregnant monkeys. Specificity of binding was assessed in competition experiments with unlabelled agonists and antagonists of known pharmacological potency. Cellular localization of OTR was determined by immunohistochemistry. In NP human uterine tissues, [3H]AVP was bound with higher affinity and greater binding capacity than [3H]OT, whereas in pregnant women and in NP and pregnant rhesus monkeys, uterine OT binding capacity was greater. OT and AVP binding sites discriminated very poorly between OT and AVP; [125I]LVA binding sites were more selective than [3H]AVP. Their ligand specificity and binding kinetics indicated the presence of two distinct populations of binding sites for OT and AVP in primate uterus. Endometrium of NP women and monkeys had low OTR and VPR concentrations. Myometrial and endometrial OTR and VPR were down-regulated in midcycle and in early human pregnancy, they were up-regulated in the secretory phase and second half of pregnancy. Immunoreactive OTR in NP uterus was localized in patches of myometrial muscle cells and small numbers of endometrial epithelial cells.  (+info)

Adenosquamous carcinoma of the endometrium. (4/1969)

An adenosquamous carcinoma of the endometrium is one which contains both malignant glandular and malignant squamous components; such tumours are considered rare in Britain but are thought to account for nearly one-third of all endometrial neoplasms in the United States. A survey of 675 cases of endometrial cancer seen during the period 1956-75 showed that the incidence of adenosquamous carcinoma was 5%, an incidence that remained static during this 20-year period. The principal difficulties encountered in the diagnosis of these neoplasms are in identifying the squamous component as such and in differentiating it from benign metaplastic squamous epithelium. The prognosis for patients with an endometrial adenosquamous carcinoma is very much worse than for women with a pure adenocarcinoma, and because these neoplasms are often wrongly identified it is possible that the currently accepted prognoses for both pure adenocarcinoma and adenoacanthoma of the endometrium may have to be revised. There appears to be a true variation in the incidence of this neoplasm between Britain and the United States.  (+info)

Heparin inhibits proliferation of myometrial and leiomyomal smooth muscle cells through the induction of alpha-smooth muscle actin, calponin h1 and p27. (5/1969)

Mast cells are widely distributed in human tissues, including the human uterus. However, the function of mast cells in uterine smooth muscle has not been clearly established. Mast cells possess secretory granules containing such substances as heparin, serotonin, histamine and many cytokines. To help establish the role of mast cells in the human myometrium, the action of heparin was investigated using smooth muscle cells (SMC) from normal myometrium and from leiomyoma. The proliferation of cultured myometrial and leiomyomal SMC was inhibited by heparin treatment. Flow cytometric analysis showed that the population in the G1 phase of the cell cycle increased under heparin treatment. Western blotting analysis showed that markers of SMC differentiation such as alpha-smooth muscle actin (alpha-SMA), calponin h1 and cyclin-dependent kinase inhibitor p27 were induced by heparin, whereas cell-cycle-related gene products from the G1 phase of the cell cycle, such as cyclin E and cdk2, were not changed. Taken together, these results indicate that heparin inhibits the proliferation of myometrial and leiomyomal SMC through the induction of alpha-SMA, calponin h1 and p27. We suggest that heparin from mast cells may induce differentiation in uterine SMC and may influence tissue remodelling and reconstruction during physiological and pathophysiological events.  (+info)

CD9 is involved in invasion of human trophoblast-like choriocarcinoma cell line, BeWo cells. (6/1969)

The CD9 molecule is expressed on human extravillous trophoblasts, which invade the endometrium during implantation and placentation. To elucidate the role of CD9 in trophoblastic function, we investigated the expression of CD9 protein and mRNA in BeWo cells, a human trophoblast-like choriocarcinoma cell line, using immunohistochemistry, Western blotting and reverse transcription-polymerase chain reaction (RT-PCR). When BeWo cells were cultured with anti-CD9 monoclonal antibodies (mAb), their invasion through the extracellular matrices was significantly enhanced in a dose-dependent manner. Cell proliferation and human chorionic gonadotrophin production were unaffected. On the other hand, culture in the presence of mAb against integrins alpha3, alpha5 and beta1, which partially block the interaction with the extracellular matrices, inhibited BeWo cell invasion. Anti-CD9 monoclonal antibody had a stimulatory effect on BeWo cell invasion in the presence of anti-integrin alpha3 antibody. In contrast, it had no effect in the presence of mAb against integrins alpha5 and beta1, which were also highly expressed on BeWo cells. These findings suggest that CD9 has a function connected with the invasive properties of BeWo cells, which is partially mediated by integrin alpha5beta1. This may relate to the involvement of CD9 in trophoblastic invasion.  (+info)

Genetic mapping of a maternal locus responsible for familial hydatidiform moles. (7/1969)

Hydatidiform mole (HM) is the product of an aberrant human pregnancy in which there is an abnormal embryonic development and proliferation of placental villi. The incidence of HM varies between ethnic groups, and occurs in 1 in every 1500 pregnancies in the USA. All HM cases are sporadic, except for extremely rare familial cases. The exact mechanisms leading to molar pregnancies are unknown. We previously postulated that women with recurrent hydatidiform moles are homozygous for an autosomal recessive defective gene. To map this gene genetically, we initiated a genome-wide scan with highly polymorphic short tandem repeats in individuals from two families with recurrent HM. Here, we demonstrate that a defective maternal gene is responsible for recurrent HM. This gene resides on chromosome 19q13.3-13.4 in a 15.2 cM interval flanked by D19S924 and D19S890. The identification of a gene for HM adds new insights into the molecular genetics of early embryogenesis and may be relevant to the large number of patients with sporadic HM.  (+info)

Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression. (8/1969)

BACKGROUND: The MDM2 oncogene functions as a negative feedback regulator of the p53 tumor suppressor. Abnormal expression of MDM2 in tumors may attenuate the p53-mediated growth arrest and apoptosis response, resulting in increased cell proliferation and resistance to chemotherapy. MATERIALS AND METHODS: We have developed phosphorothioate antisense oligodeoxynucleotides optimized for inhibition of MDM2 expression and investigated the role of MDM2 in a large panel of tumor cell lines. RESULTS: Inhibition of MDM2 expression in 15 tumor types containing wild-type p53 results in a significant induction of nuclear p53 accumulation. The increase in p53 level is due to prolonged half-life and is associated with an increase in p53 transcriptional activity, growth inhibition, or apoptosis. Inhibition of MDM2 expression is also sufficient to induce nuclear p53 accumulation in several cell lines with cytoplasmic p53. CONCLUSIONS: The MDM2 negative feedback loop is important for maintenance of p53 at a low level by promoting p53 degradation. Nuclear export and degradation by MDM2 may contribute to the p53 nuclear exclusion phenotype. Inhibition of MDM2 expression can effectively activate p53 in most tumor types, including those without MDM2 overexpression, and may have broad anti-tumor potential.  (+info)

Conditions: Malignant Female Reproductive System Neoplasm; Malignant Hepatobiliary Neoplasm; Partner; Stage III Breast Cancer; Stage III Cervical Cancer; Stage III Colorectal Cancer; Stage III Lung Cancer; Stage III Prostate Cancer; Stage III Skin Melanoma; Stage III Uterine Corpus Cancer; Stage IIIA Breast Cancer; Stage IIIA Cervical Cancer; Stage IIIA Colorectal Cancer; Stage IIIA Lung Carcinoma; Stage IIIA Skin Melanoma; Stage IIIA Uterine Corpus Cancer; Stage IIIB Breast Cancer; Stage IIIB Cervical Cancer; Stage IIIB Colorectal Cancer; Stage IIIB Lung Carcinoma; Stage IIIB Skin Melanoma; Stage IIIB Uterine Corpus Cancer; Stage IIIC Breast Cancer; Stage IIIC Colorectal Cancer; Stage IIIC Skin Melanoma; Stage IIIC Uterine Corpus Cancer; Stage IV Breast Cancer; Stage IV Cervical Cancer; Stage IV Colorectal Cancer; Stage IV Lung Cancer; Stage IV Prostate Cancer; Stage IV Skin Melanoma; Stage IV Uterine Corpus Cancer; Stage IVA Cervical Cancer; Stage IVA Colorectal Cancer; Stage IVA Uterine ...
Conditions: Malignant Female Reproductive System Neoplasm; Malignant Hepatobiliary Neoplasm; Partner; Stage III Breast Cancer; Stage III Cervical Cancer; Stage III Colorectal Cancer; Stage III Lung Cancer; Stage III Prostate Cancer; Stage III Skin Melanoma; Stage III Uterine Corpus Cancer; Stage IIIA Breast Cancer; Stage IIIA Cervical Cancer; Stage IIIA Colorectal Cancer; Stage IIIA Lung Carcinoma; Stage IIIA Skin Melanoma; Stage IIIA Uterine Corpus Cancer; Stage IIIB Breast Cancer; Stage IIIB Cervical Cancer; Stage IIIB Colorectal Cancer; Stage IIIB Lung Carcinoma; Stage IIIB Skin Melanoma; Stage IIIB Uterine Corpus Cancer; Stage IIIC Breast Cancer; Stage IIIC Colorectal Cancer; Stage IIIC Skin Melanoma; Stage IIIC Uterine Corpus Cancer; Stage IV Breast Cancer; Stage IV Cervical Cancer; Stage IV Colorectal Cancer; Stage IV Lung Cancer; Stage IV Prostate Cancer; Stage IV Skin Melanoma; Stage IV Uterine Corpus Cancer; Stage IVA Cervical Cancer; Stage IVA Colorectal Cancer; Stage IVA Uterine ...
Anaplastic Astrocytoma Anaplastic Oligoastrocytoma Anaplastic Oligodendroglioma Estrogen Receptor Negative Estrogen Receptor Positive Glioblastoma Hormone-Resistant Prostate Cancer Metastatic Prostate Carcinoma Metastatic Renal Cell Cancer Recurrent Adult Brain Neoplasm Recurrent Bladder Carcinoma Recurrent Breast Carcinoma Recurrent Colorectal Carcinoma Recurrent Esophageal Carcinoma Recurrent Gastric Carcinoma Recurrent Hepatocellular Carcinoma Recurrent Lung Carcinoma Recurrent Melanoma Recurrent Ovarian Carcinoma Recurrent Prostate Carcinoma Recurrent Renal Cell Carcinoma Recurrent Uterine Corpus Carcinoma Resectable Hepatocellular Carcinoma Sarcoma Stage IA Breast Cancer Stage IA Ovarian Cancer Stage IA Uterine Corpus Cancer Stage IB Breast Cancer Stage IB Ovarian Cancer Stage IB Uterine Corpus Cancer Stage IC Ovarian Cancer Stage II Uterine Corpus Cancer Stage IIA Breast Cancer Stage IIA Lung Carcinoma Stage IIA Ovarian Cancer Stage IIB Breast Cancer Stage IIB Esophageal Cancer Stage IIB ...
Objective: The aim of the study was to audit the outcomes of patients with corpus cancer managed with a fast track surgery (FTS) program. Design: Clinical audit of outcomes after laparotomy for corpus cancer and managed by FTS principles. Setting: Tertiary hospital, University based subspecialty gynaecological oncology practice. Population or Sample: Consecutive patients with uterine corpus cancer. There were no exclusions. Methods: Three year audit of FTS Database. Main Outcome Measures: Ability to tolerate early oral feeding (EOF), length of stay (LOS), perioperative complication rate and readmission rate. Results: Sixty six patients were operated upon whose median age was 59.5 years. Forty six (70%) had stage I disease, 7 (11%) stage II, 9 (14%) stage III and 4 (6%) had stage IV disease. Twenty seven (41%) had lymph node sampling performed. Median operating time was 2.5 hours. Mean BMI was 30 kg/m2 (Range: 18 - 47). Fifty patients (76%) were classified as over-weight or obese. Twenty four patients
Uterine cancer indications are not something that should be overlooked. If you are currently experiencing evidences that are associated with uterine cancer, you need to seek the help of a medical. professional. Uterine cancer manifestations are often the result of other factors, but that is something that merely medical doctors can determine. If you would like to learn more about uterine cancer indications, please continue to read this sheet. If your uterine cancer manifestations have already been diagnosed as cancer, and you are searching for management, you are able wishes to browse our locate to learn about the new and innovative therapies we offer.. Most cases of uterine cancer occur in the liner( endometrium) of the uterus. This article uses the word uterine cancer to refer to this type of cancer, also known as endometrial cancer. This article does not discuss a uncommon type of uterine cancer that can occur in the muscles or other tissues that support the uterus. Click Uterine Sarcoma ...
We identified invasive uterine cancer cases among non-Hispanic White (henceforth, abbreviated as White), Black, and Hispanic women diagnosed during 2004 to 2008 using incidence data obtained from the North American Association of Central Cancer Registries (NAACCR) for 49 states and the District of Columbia. NAACCR certifies population-based central cancer registries participating in the National Cancer Institutes SEER program and/or the Centers for Disease Control and Preventions National Program of Cancer Registries, and aggregates and distributes surveillance data submitted by the registries for epidemiologic research (14, 15). Consistent with NAACCR and SEER convention, incidence rates are presented as an aggregate over the most recent 5 years of available data at the time of the study, in this case 2004 through 2008, for increased stability. Age-specific case counts for site codes C54.0-C54.9 (corpus uterus) and C55.9 (uterus, not otherwise specified; ref. 16) were retrieved using ...
Positron Emission Tomography (PET) or integrated PET/Computed Tomography (PET/CT) with 18F-Fluoro-Deoxy-Glucose (18F-FDG) is a functional imaging modality, useful in the characterization of undetermined morphological findings, and in the staging/re-staging of a large number of malignancies. Although its use in uterine malignancies has been poorly investigated, in recent years the employment of this technique has constantly increased. In this review, we evaluate the role of PET (/CT) with 18FFDG in uterine malignancies (cervical and endometrial cancers as well as uterine sarcomas), underlying its advantages and discussing its limitations. Metabolic and anatomic information given by PET/CT with 18F-FDG could be useful in the evaluation of local and distant disease involvement at the staging, in the detection of disease recurrence, and in the evaluation of the response after chemotherapy and/or radio-therapy.
10 mitosis per high power field. In contrast a uterine leiomyoma as a benign lesion would have < 5 mitosis per high power field. Therapy is based on staging and patient condition and utilizes one or more of the following approaches. Surgery is the mainstay of therapy if feasible involving total abdominal hysterectomy with bilateral salpingo-oophorectomy. Other approaches include radiation therapy, chemotherapy, and hormonal therapy. Prognosis is relatively poor. Uterine sarcoma are rare, out of all malignancies of the uterine body only about 4% will be uterine sarcomas. Generally, the cause of the lesion is not known, however patients with a history of pelvic radiation are at higher risk. Most tumors occur after menopause. Women who take long-term tamoxifen are at higher risk. Uterine fibroids Leiomyosarcoma Zagouri F, Dimopoulos AM, Fotiou S, Kouloulias V, Papadimitriou CA (2009). Treatment of early uterine sarcomas: disentangling adjuvant modalities. World J Surg Oncol. 7: 38. ...
Uterine cancer description with its various causes along with its various risk factors. The use of birth control pills is said to decrease the risk of developing uterine cancer. Different uterine cancer treatment methods are also discussed.
Uterine cancer. Light micrograph (LM) of a section of a sarcoma of the uterus. Sarcomas of the uterus are uncommon, and may arise from connective tissue, smooth muscle or the endometrial stroma. Uterine sarcoma is a rare form of malignancy, occurring in 2 5% of all patients with uterine malignancy. Surgery is used to diagnose, stage, and treat uterine sarcoma. The prognosis for women with uterine sarcoma is primarily dependent on the extent of disease at the time of diagnosis. Characteristically uniform oval and spindle-shaped cells are seen. Magnification: x 250 when printed at 10 centimetres wide. Human tissue. - Stock Image C021/6183
This research analyzed other 36 studies and overall it involved 143.019 women coming from high-income countries. The data in the study is from between 1965 and 2014. The findings indicate that the risk of uterine cancer was reduced in the case of women who took oral contraceptives for an extended period of time.. Hormonal birth control reduces the risk of uterine cancer by 25-50 percent. A woman who has never taken oral contraceptives has 2 to 3 percent chances of developing uterine cancer before she turns 75 years. A woman who takes birth-control pills for five years has 1.7 percent lower risk of developing uterine cancer. The risk drops to 1.3 percent after ten years of using oral contraceptives and after 15 years the risk is of only 1 percent.. The study also indicates that the protective effect against cancer which contraceptives have lasts for at least 30 years even after the woman has stopped taking them. It was also observed that the reduced risk of cancer varied according to the type of ...
Uterine Cancer, Read about Uterine Cancer symptoms, causes, diagnosis, and treatment. Also read Uterine Cancer articles about how to live with Uterine Cancer, and more.
Uterine Cancer, Read about Uterine Cancer symptoms, causes, diagnosis, and treatment. Also read Uterine Cancer articles about how to live with Uterine Cancer, and more.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2] Synonyms and Keywords: Endometrial adenocarcinoma; adenocarcinoma - endometrium; adenocarcinoma - uterus; cancer - endometrial; uterine corpus cancer; endometrial carcinoma; cancer of the endometrium; cancer of endometrium; Neoplasm of endometrium; Endometrial neoplasm. ...
If uterine cancer is diagnosed, your doctor needs to learn the extent (stage) of the disease to help you choose the best treatment. The stage is based on whether the cancer has invaded nearby tissues or spread to other parts of the body.. When cancer spreads from its original place to another part of the body, the new tumor has the same kind of abnormal cells and the same name as the primary (original) tumor. For example, if uterine cancer spreads to the lung, the cancer cells in the lung are actually uterine cancer cells. The disease is metastatic uterine cancer, not lung cancer. Its treated as uterine cancer, not as lung cancer. Doctors sometimes call the new tumor distant disease.. To learn whether uterine cancer has spread, your doctor may order one or more tests:. ...
The uterus is the female reproductive organ where the unborn baby grows and develops until birth. This muscular organ is connected to the vagina by the cervix and contains entrances for the two fallopian tubes, which transfer eggs from the ovaries. The uterus is a highly hormone sensitive organ with monthly bleeding and shedding cycles (menstruation) in the absence of pregnancy. The growth of the most common uterine cancer, adenocarcinoma, is also sensitive to female hormones. Uterine cancer usually arises from the surface of the uterus or endometrium and less frequently from glands in the uterus. For most women, uterine cancer is brought to medical attention because of unanticipated or problematic bleeding from the uterus, usually occurring after menopause. Fortunately, 80% of women diagnosed after developing abnormal bleeding will have cancer limited to the uterus (stage I and II) and a high proportion are cured.. Uterine (endometrial) cancer is one of the most common gynecologic cancers in ...
uterine cancer / corpus uteri - Incidence patient population data split by country and gender, starting 1980 and ending 2100 , Epiomic ...
Stage 2 uterine cancer is the second phase of cancer of the uterus. It is also referred to as endometrial cancer. In stage 2 uterine cancer, the disea
Find the best uterine cancer doctors in Bangalore. Get guidance from medical experts to select uterine cancer specialist in Bangalore from trusted hospitals - credihealth.com
Find the best uterine cancer doctors in Kolkata. Get guidance from medical experts to select uterine cancer specialist in Kolkata from trusted hospitals - credihealth.com
If endometrial (uterine) cancer is diagnosed, your doctor needs to learn the extent (stage) of the disease to help you choose the best treatment. The stage is based on whether the cancer has invaded nearby tissues or spread to other parts of the body.. When cancer spreads from its original place to another part of the body, the new tumor has the same kind of abnormal cells and the same name as the primary (original) tumor. For example, if uterine cancer spreads to the lung, the cancer cells in the lung are actually uterine cancer cells. The disease is metastatic uterine cancer, not lung cancer. Its treated as uterine cancer, not as lung cancer. Doctors sometimes call the new tumor distant disease.. To learn whether uterine cancer has spread, your doctor may order one or more tests:. ...
U.S. researchers say theyve identified the molecular trigger of fibroid uterine tumors -- a single stem cell develops a mutation and grows uncontrollably.
Cancer of the uterus is the most common gynaecological cancer affecting women, and is mostly found in the age range between 50 70 years. The most common cancer of the uterus is that which affects the endometrium or the lining of the uterus. This is called endometrial cancer, and the exact cause is not known. Cancer may also develop in muscle layers of the uterus.. Uterine cancer is not sexually transmitted. Other names for this disease are: cancer of the womb, and cancer of the lining of the womb.. Symptoms of uterine cancer include: unusual bleeding, and a watery, bloody, sometimes smelly vaginal discharge. Less common symptoms include: bloating and abdominal discomfort, pain during sexual intercourse, and with advancement of the cancer tiredness, loss of weight and constipation may occur.. Some useful websites with information and resources: ...
Stage II uterine cancer involves the main body of the uterus and the cervix. Stage IIA cancer involves the uterus and only the surface lining of the cervix. Stage IIB cancer involves the uterus and extends into deep layers of the cervix. Optimal treatment of patients with stage II uterine cancer often requires more than…
If you have stage 1 uterine cancer, your doctor will likely recommend a hysterectomy, or surgical removal of the uterus. Sometimes the fallopian tubes
One killer disease among women now adays is cancer of the breast, uterine cancer or ovarian cancer. Any of this kind of cancer may victimized a women anytime. We all know that cancer is an unknown cause but according to some research, diet does influence the risk of cancer. High intake of fats and low intake of fruits and vegetables may lead a woman prone to cancer. It is emphasize that we have to eat fruits and vegetables with low fat and high fiber diet to decrease the risk of cancer. We (woman ) must have to consume regularly rich foods with high content of lycopene like tomato sauce. . According to research, these food lessens up to 28% the risk of ovarian, breast and uterine cancer ...
How to Recognize Uterine Cancer Symptoms. Uterine cancer (also called endometrial cancer) is a serious condition that affects millions of women annually. It most commonly occurs in women who are going through, or who have gone through,...
Uterine cancer is the most common cancer of the female reproductive organs. Learn uterine cancer symptoms, signs, causes, risk factor, and treatment.
Learn about the different types of uterine cancer as well as incidence and cure rates and diagnosis and treatment options for stage I-IV uterine cancer.
Press Release issued May 16, 2014: Reportstack, provider of premium market research reports announces the addition of Uterine Cancer - Pipeline Review, H1 2014 market report to its offering Uterine Cancer - Pipeline Review, H1 2014
Corpus cancer is the most frequently occurring female genital cancer. Approximately 47,100 cases of corpus cancer were predicted to occur in the United States in 2012, making it the fourth most common cancer among women; of these women, approximately 8,000 will die from the disease.
Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Lipomatous Uterine Tumors
Question - Ultrasound shows fibromyoma, same symptoms as uterine cancer. Can ultrasound distinguish between malignant and benign?. Ask a Doctor about diagnosis, treatment and medication for Fibromyomas, Ask an OBGYN, Gynecologic Oncology
Upon completion the study will be published in peer reviewed, open access journals in order to increase the dissemination of the results generated. It will also form the basis for a thesis to be put forward for the award of a PhD at the University of Manchester and will be available to be viewed in this format. The results of the study will also be presented at national and international meetings to inform both clinicians and scientists with an interest in endometrial cancer. An abstract submission is being prepared for presentation at the European Gynaecological Oncology Congress in November 2017, submission to journals is likely to be in early 2018. Patients recruited to the study will be informed of the trial results and public engagement events will be undertaken to increase awareness of the studys findings within the lay population ...
Supplemental Data File - Study Summaries: Uterine Adenocarcinoma in the rat induced by Afidopyropen. An analysis of the lesions induction, progression and its relevance to humans.
Adding the monoclonal antibody drug trastuzumab-already used to treat certain breast cancers-to the chemotherapy regimen of women with a rare form of uterine cancer lengthens the amount of time their tumors are kept from growing, according to Johns Hopkins Medicine researchers conducting a small phase II trial of the regimen, testing its safety and value.. The results of the trial, published online ahead of print on March 27 in the Journal of Clinical Oncology, show that the drug extended the length of time to tumor progression by four to eight months in the seven-year trial. The researchers say this may lead to new national guidelines for treating this cancer subtype, known as uterine serous carcinoma. Adding trastuzumab (Herceptin) to standard chemotherapy regimen improves survival in women with rare form of uterine cancer. HER2/neu mutation guides personalized uterine cancer treatment in new phase II trial. Read the entire article at ...
Uterine cervical cancer is the second most common female malignancy. Therapy monitoring is essential to detect early recurrence. Diffusion-weighted magnetic resonance imaging is an emerging MRI imaging technique which has a potential value for the detection of primary and recurrent disease and for the assessment of response to therapy. The purpose of this project is to evaluate the predictive value of DWI during and after therapy in the prediction of recurrence of cervical uterine cancer. It will be considered whether DWI is able to provide early information about the response to therapy. This could enable the identification of less- or non-responsive tumors and in this way therapy can be adapted as soon as possible. Hence the investigators could offer the patient a more efficient treatment scheme and a reduction in toxicity related to the treatment could be established ...
in Disease Markers (2010), 28(5), 267-72. Cervical and endometrial uterine carcinomas are heterogeneous groups of cancers, which are preceded by preneoplastic lesions. More accurate tools are needed to improve the diagnosis and to define markers ... [more ▼]. Cervical and endometrial uterine carcinomas are heterogeneous groups of cancers, which are preceded by preneoplastic lesions. More accurate tools are needed to improve the diagnosis and to define markers which may be relevant for the diagnosis, prediction of disease progression and therapeutic response.High throughput technologies for testing and validating molecular targets in cancer lesions and in their precursors are presently available. Among them, the tissue microarray (TMA) presents the advantage of a morphological control of the analyzed tissue fragment. In this article, we review the different aspects of the TMA technology with a special consideration to a uterine carcinogenesis model. [less ▲]. Detailed reference viewed: 13 (3 ...
Endometrial Cancer (Uterine Cancer) Diagnostics (costs for program #132691) ✔ University Hospital Tubingen ✔ Department of Gynecology, Mammology and Obstetrics ✔ BookingHealth.com
Uterine Cancer which is also known as Endometrial Cancer is characterized by the irregular growth of cells in the Uterus. The uterus, or womb, is the place where a baby grows when a woman is pregnant.
Hi, Alida!. I am 66 and have been dealing with this crud for 10 years now. in 2004 I was diagnosed with uterine cancer and had a hysterectomy with the removal of the ovaries at the same time. Before the surgery, the gynecological oncologist thought it was probably Stage 1C. Ended up being IIIC. We immdeiately did 8 sessions of adriamyicin/cisplatin. Only real problem I had was it lowered the magnesium in my system so low that 10 days after the treatment, Id end up getting a 4 hour transfusion of the magnewium. Seemed to work great.. In 2008, like some of the others on the forum, ended up going to the emergency room for bronchitis. Could tell from the reactions to the X-rays that something else might be going on. 3 days later got a letter suggesting that I contact my oncologist. We decided to just watch the nodule with CT Scans every 3 months. Worked fine - wasnt seeing any growth until 2010, when it tripled in size between two scans. We decided to try targeted radiation since the nodule is ...
If you report uterine cancer symptoms soon enough treatment can be curative because the womb cancer (Endometrial cancer) wont have invaded the womb lining.
Tell your doctor about bleeding and other signs of endometrial cancer. Recognizing these warning uterine cancer symptoms offers you your best hope for effective treatment.
New drug combinations in development offer hope to women who are looking for HRT alternatives. A class of drugs known as SERMS of which Evista is a member, used in combination with estrogen has shown promising results in clinical studies. A SERM will protect against the uterine cancer causing effect of estrogen so progesterone is no longer needed with HRT. This immediately reduces many of the undesirable effects of HRT found in the WHI including breast cancer risk and producing better cholesterol effects. This combination of drugs is referred to as a tissue-selective estrogen complex (TSEC). Other advantages of TSEC treatment are improvement in bone density (lower osteoporosis risk) and possible reduction in coronary artery disease development. Although TSEC treatment is not yet FDA approved for treatment of post-menopausal symptoms, individual doctors can prescribe this if they feel the available information is favorable and the risk/benefit ratio is in favor of the patients well being ...
The latest uterine cancer incidence statistics for the UK for Health Professionals. See data for age, trends over time, UK region and more.
Endometrial uterine cancer mainly affects women. This is a cancer in the uterus that is considered the fourth largest type of cancer in women. A woman can
Breast metastasis from extra-mammary malignancy is rare, constituting 2% of breast tumors. Uterine leiomyosarcoma is a rare soft tissue neoplasm comprising 1% of all uterine malignancies. This report presents the first case of uterine leiomyosarcoma metastasis of the breast. A 44-year-old woman, G4P3AA1, presented with a one-week history of painless bilateral breast lumps. Twelve years previously she had undergone a right salpingo-oophorectomy and hysterectomy for uterine leiomyosarcoma. An excisional biopsy of the breast nodule was performed, and the histopathological study revealed the nodule was composed of spindle cells, typical of breast metastasis with uterine leiomyosarcoma found in the immunohistochemical study. The patient was healthy and symptom free during the 12 month post-operative follow-up period.
Halder SK, Goodwin JS, Al-Hendy A. 1,25-Dihydroxyvitamin D3 reduces TGF-beta3-induced fibrosis-related gene expression in human uterine leiomyoma cells. J Clin Endocrinol Metab. 2011 Apr; 96(4):E754-62 ...
TY - JOUR. T1 - Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma. T2 - Morphological significance of calponin h1. AU - Hayashi, Takuma. AU - Horiuchi, Akiko. AU - Sano, Kenji. AU - Hiraoka, Nobuyoshi. AU - Kasai, Mari. AU - Ichimura, Tomoyuki. AU - Sudo, Tamotsu. AU - Nishimura, Ryuichiro. AU - Ishiko, Osamu. AU - Shiozawa, Tanri. AU - Kanai, Yae. AU - Yaegashi, Nobuo. AU - Aburatani, Hiroyuki. AU - Konishi, Ikuo. PY - 2012/6/21. Y1 - 2012/6/21. N2 - Uterine leiomyosarcoma (LMS) is a highly metastatic smooth muscle neoplasm for which calponin h1 is suspected to have a biological role as a tumor-suppressor. We earlier reported that LMP2-null mice spontaneously develop uterine LMS through malignant transformation of the myometrium, thus implicating this protein as an anti-tumorigenic candidate as well. In the present study, we show that LMP2 may negatively regulate LMS independently of its role in the proteasome. Moreover, several lines of evidence indicate that ...
TY - JOUR. T1 - Polypoid or non-polypoid? A novel dichotomous approach to uterine carcinosarcoma. AU - Djordjevic, B.. AU - Gien, L. T.. AU - Covens, A.. AU - Malpica, A.. AU - Khalifa, M. A.. N1 - Copyright: Copyright 2009 Elsevier B.V., All rights reserved.. PY - 2009/10. Y1 - 2009/10. N2 - Objective. To examine the impact of the polypoid morphology of uterine carcinosarcoma on clinical outcome, as well as its relationship to well-established prognostic factors. Methods. In a retrospective study of fifty eight patients with uterine carcinosarcoma treated with hysterectomy, we correlated the polypoid status of tumors with stage, lymphatic vascular invasion, myometrial invasion, size, carcinoma to sarcoma ratio, type of carcinomatous and sarcomatous components, disease free survival and overall survival. Results. By multivariate analysis, the polypoid status had no impact on disease free survival (p = 0.8958), but approached significance as a positive predictor for overall survival (p = 0.0569); ...
Uterine leiomyomas, or fibroids, are extremely common tumors. Regardless of their benign nature, fibroids can cause considerable morbidity. Women with African ancestry have a threefold increased risk of developing uterine leiomyomas with a greater symptom severity when compared to white women. Recently, we demonstrated that exon 2 of the MED12 gene is somatically altered in up to 70 per cent of uterine leiomyomas in a series of Finnish (Caucasian) patients. To validate these results in other populations, we sequenced a set of 28 uterine leiomyomas for MED12 exon 2 mutations from 18 different Black African or Coloured South African patients. We observed 14 mutation positive lesions (50%). When corrected by tumor size, these results are very similar to those derived in the Finnish material. This study confirms a major role of MED12 in the genesis of leiomyomas, regardless of ethnicity.
This is a case study of twin pregnancy, going through a complete hydatidiform mole with living fetus. The pregnant woman had a previous partial hydatidiform mole, diagnosed and confirmed five months before the pregnancy which is the subject of this study. The first suspected diagnosis was made by means of a medical external ultrasound scan, confirmed by other tests, such as the dosage of β-HCG. Besides the bibliographic review, this study addresses legal aspects of the Brazilian system which does _disibledevent=line-height:1.5;text-align:justify;white-space:normal;>ugh uterine evacuation, featuring a criminal abortion. For the safety of the medical staff and the pregnant woman herself, there was the need for a special authorization from the Public Prosecution to the medical procedure.
Fibroids that occur inside the myometrial layer of the uterus are called intramural fibroids. They can grow into the open space inside the uterus and may also include a stalk. These fibroids have limited space to grow. Uterine fibroids are the unusual muscular outgrowths that grow in a females uterus. Intramural fibroids are the most common type of fibroids, grow within the uterine wall. Estrogen is a hormone. Submucosal fibroids that grow underneath the uterine lining and may crowd the uterus cavity, leading to heavy bleeding. Subserosal fibroids grow on the outside of the uterine wall. What causes … Submucosal fibroid: These fibroids are not as common as the other types of fibroids. Treatment for uterine fibroids depends on your symptoms. Intramural fibroids grow in the muscle tissue of the uterus and are the most common type of fibroids. Submucosal fibroids may cause heavy menstrual bleeding and trouble conceiving. Fibroids are non-cancerous tumors that abnormally grow in a womans uterus. ...
TY - JOUR. T1 - Tumor immunoediting, from T cell-mediated immune surveillance to tumor-escape of uterine leiomyosarcoma. AU - Hayashi, Takuma. AU - Horiuchi, Akiko. AU - Sano, Kenji. AU - Hiraoka, Nobuyoshi. AU - Ichimura, Tomoyuki. AU - Ishiko, Osamu. AU - Kanai, Yae. AU - Yaegashi, Nobuo. AU - Aburatani, Hiroyuki. AU - Shiozawa, Tanri. AU - Tonegawa, Susumu. AU - Konishi, Ikuo. PY - 2013. Y1 - 2013. N2 - The majority of smooth muscle tumors found in the uterus are benign, but uterine leiomyosarcomas (LMSs) are extremely malignant, with high rates of recurrence and metastasis. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not clearly understood. The presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules is important for tumor rejection by cytotoxic T-lymphocytes (CTLs). Such antigenic ...
TY - JOUR. T1 - New concepts in the treatment of uterine leiomyomas. AU - Stewart, Elizabeth A.. AU - Nowak, Romana A.. PY - 1998/10. Y1 - 1998/10. N2 - Uterine leiomyomas are a common clinical occurrence for gynecologists. The current approach to treating these neoplasms is shaped by classic surgical principles and the knowledge that these tumors are responsive to the gonadal steroids estrogen and progesterone. As knowledge of leiomyomas advances through the techniques of molecular biology and molecular genetics, new concepts are developed that go beyond just myomas as steroid-responsive tumors. Understanding the molecular events involved in the transformation of a normal myometrial cell into a neoplastic cell and the subsequent growth of these leiomyoma cells will be important in determining the pathogenesis of these tumors and providing new targets for treatment. Knowing the role of peptide growth factors, including basic fibroblast growth factor and transforming growth factor-beta, in the ...
1. Catherino WH, Parrott E, Segars J. Proceedings from theNational Institute of Child Health and Human Development conference on the Uterine Fibroid Research Update Workshop. Fertil Steril. 2011;95:9-12 2. Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect. 2003;111:1037-54 3. Sandberg AA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyoma. Cancer genetics and cytogenetics. 2005;158:1-26 4. Parker WH. Etiology, symptomatology, and diagnosis of uterine myomas. Fertil Steril. 2007;87:725-36 5. Makinen N, Mehine M, Tolvanen J, Kaasinen E, Li Y, Lehtonen HJ. et al. MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. Science. 2011;334:252-5 6. Heinonen HR, Sarvilinna NS, Sjöberg J, Kämpjärvi K, Pitkänen E, Vahteristo P. et al. MED12 mutation frequency in unselected sporadic uterine leiomyomas. Fertil Steril. 2014;102:1137-42 7. Mehine M, Kaasinen E, ...
TY - JOUR. T1 - Co-expression of GPR30 and ERβ and their association with disease progression in uterine carcinosarcoma. AU - Huang, Gloria S.. AU - Gunter, Marc J.. AU - Arend, Rebecca C.. AU - Li, Maomi. AU - Arias-Pulido, Hugo. AU - Prossnitz, Eric R.. AU - Goldberg, Gary L.. AU - Smith, Harriet O.. PY - 2010/9. Y1 - 2010/9. N2 - Objective: We sought to evaluate the expression of G protein-coupled receptor 30 (GPR30) and estrogen receptor (ER)β in uterine carcinosarcoma (CS). Study Design: Immunohistochemistry was performed using antibodies to GPR30, ERβ, ERα, and progesterone receptor (PR). The staining intensity and percentage of positive cells were scored for each tissue section. Expression levels were compared using the Wilcoxon rank sum test. Correlation was evaluated by Spearman rho and logistic regression. Results: Compared with normal endometrium, CS had lower ERα and PR expression (both P , .01) but higher GPR30 epithelial expression (P = .03). Advanced-stage CS had higher GPR30 ...
A 59-year-old woman, diagnosed 7 years ago with uterine leiomyosarcoma (ULMS), developed several intrathoracic, pelvic and lately intra-abdominal and brain metastases. On each occasion, surgical resection was followed by a course of failed chemotherapy. Lately she presented with acute neurological deterioration and focal signs. Magnetic resonance imaging demonstrated two presumed brain parenchymal lesions involving the supratentorial and infratentorial compartments. She underwent surgical resection of the left cerebellar lesion. Histological analysis of the brain specimen confirmed the presence of metastatic ULMS. Leiomyosarcoma of the uterus is an uncommon tumor with a very aggressive course and poor prognosis. Multiple organ metastases from ULMS are an extremely rare condition, and prognostically alarming despite current treatments ...
Cell culture is considered the standard media used in research to emulate the in vivo cell environment. Crucial in vivo experiments cannot be conducted in humans and depend on in vitro methodologies such as cell culture systems. However, some procedures involving the quality control of cells in culture have been gradually neglected by failing to acknowledge that primary cells and cell lines change over time in culture. Thus, we report methods based on our experience for monitoring primary cell culture of human myometrial cells derived from uterine leiomyoma. We standardized the best procedure of tissue dissociation required for the study of multiple genetic marker systems that include species-specific antigens, expression of myofibroblast or myoblast markers, growth curve, serum deprivation, starvation by cell cycle synchronization, culture on collagen coated plates, and 17 beta-estradiol (E-2) and progesterone (P-4) effects. The results showed that primary myometrial cells from patients with ...
OBJECTIVE: Trabectedin demonstrated significantly improved disease control in leiomyosarcoma and liposarcoma patients in a global phase 3 trial (NCT01343277). A post hoc analysis was conducted to assess the efficacy and safety of trabectedin or dacarbazine in women with uterine leiomyosarcoma (uLMS), the largest subgroup of enrolled patients (40%). METHODS: Of 577 patients randomized 2:1 to receive trabectedin 1.5mg/m2 by 24-hour IV infusion or dacarbazine 1g/m2 by 20-120-minute IV infusion once every three weeks, 232 had uLMS (trabectedin: 144; dacarbazine: 88). The primary endpoint was overall survival (OS); secondary endpoints were progression-free survival (PFS), objective response rate (ORR), clinical benefit rate (CBR: complete responses+partial responses+stable disease [SD] for at least 18weeks), duration of response (DOR), and safety. RESULTS: PFS for trabectedin was 4.0months compared with 1.5months for dacarbazine (hazard ratio [HR]=0.57; 95% CI 0.41-0.81; P=0.0012). OS was similar ...
http://www.hexareports.com/report/uterine-leiomyoma-uterine-fibroids-pipeline-review-h2-2017. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.The Uterine Leiomyoma (Uterine Fibroids) (Non-Malignant Disorders) pipeline guide also reviews of key players involved in therapeutic development for Uterine Leiomyoma (Uterine Fibroids) and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 5, 1, 1, 1, 5 and 2 respectively. Similarly, the Universities portfolio in Discovery stages comprises 1 molecules, respectively.. Uterine Leiomyoma (Uterine Fibroids) (Non-Malignant Disorders) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision ...
Untreated Uterine Fibroids Lead to Sterility Problems. Bookmark . Depending on the size of your fibroid and the symptoms you are experiencing, your doctor may want to simply watch the fibroid, or he or she may recommend. The mean diameter of type 2 submucosal fibroids was 3.8 ± 0.9 cm (range: 2.0-5.0 cm) for 39 patients in the FUS group and 3.5 ± 0.8 cm (range: 2.0-4.8 cm) for the 42 patients enrolled in the TCRM group. Submucosal fibroids are visualized and distinguished from all other fibroids, including at least intramural fibroids and subserosal fibroids, and the identified submucosal fibroids are selectively treated by delivering energy from the energy delivery element to the submucosal fibroid(s) while not targeting the other fibroid(s), if any. ... called a leiomyosarcoma. Submucosal fibroids bulge into the uterine cavity. Transverse image of the same fibroid. Louisville Fibroids can diagnose a submucosal fibroid with a digital pelvic exam along with a traditional ultrasound, and ...
TY - JOUR. T1 - Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells. AU - Dutta-Roy, Asim K. AU - Taylor, J AU - Gordon, Margaret Jane. AU - Hoggard, Nigel. AU - Campbell, Fiona Margaret. PY - 2002/12/6. Y1 - 2002/12/6. N2 - Arachidonic acid at 100 nM stimulated internalisation of I-125-leptin in human placental choriocarcinoma (BeWo) cells by Mold compared with controls. In contrast, eicosapentaenoic acid at similar concentration decreased internalisation of leptin by 2-fold. Use of ibuprofen and indomethacin (inhibitors of prostaglandin synthesis) inhibited the stimulatory effect of arachidonic acid. Prostaglandin E-2, a cyclooxygenase metabolite of arachidonic acid, stimulated internalisation of leptin by these cells. All these data demonstrate that stimulation of leptin internalisation by arachidonic acid in placental trophoblasts may be mediated via prostaglandin E2. (C) 2002 Elsevier Science (USA). All rights reserved.. AB - Arachidonic ...
When youre pregnant, your baby is nourished through your placenta. The placenta starts to develop when one of your eggs is fertilized, but occasionally, your body can over-produce the raw material that will form the placenta, resulting in a mass or growth that is called a hydatidiform mole.. This condition occurs in two distinct forms: partial and total. A partial molar pregnancy occurs when there is an abnormal mass or growth in the placenta along with a fetus, and a complete molar pregnancy happens when a woman has an abnormal growth in her placenta, but no fetus to go with it.. Both types of molar pregnancy occur as the result of an abnormality during egg fertilization. The embryo receives two copies of the fathers chromosomes, making it impossible for it to survive. Doctors believe there may be links between low levels of vitamin A, animal fats and proteins in the diet and molar pregnancies. Women who get pregnant later in life also have an increased chance of molar pregnancy.. ...
When youre pregnant, your baby is nourished through your placenta. The placenta starts to develop when one of your eggs is fertilized, but occasionally, your body can over-produce the raw material that will form the placenta, resulting in a mass or growth that is called a hydatidiform mole.. This condition occurs in two distinct forms: partial and total. A partial molar pregnancy occurs when there is an abnormal mass or growth in the placenta along with a fetus, and a complete molar pregnancy happens when a woman has an abnormal growth in her placenta, but no fetus to go with it.. Both types of molar pregnancy occur as the result of an abnormality during egg fertilization. The embryo receives two copies of the fathers chromosomes, making it impossible for it to survive. Doctors believe there may be links between low levels of vitamin A, animal fats and proteins in the diet and molar pregnancies. Women who get pregnant later in life also have an increased chance of molar pregnancy.. ...
The clinical behaviors and cytogenetics of solitary uterine leiomyomas (SUL) and multiple uterine leiomyomas (MUL) vary, which greatly affects the choice of treatments for reproductive-aged patients with leiomyomas. Our previous study demonstrated that a series of microRNAs, including miR-146b-5p, are dysregulated and play important roles in the development of SUL and MUL. Long non-coding RNAs (lncRNAs) can participate in the pathogenesis of several diseases by regulating the expression of microRNAs; however, their roles in regulating miR-146b-5b and in the pathology of leiomyomas are unclear. Pair-matched uterine leiomyoma and adjacent normal myometrium tissue samples were collected from 37 patients with leiomyomas, including 15 with SUL and 22 with MUL. Six paired samples (three SUL and three MUL samples) were used for lncRNAs microarray analysis. Targeted lncRNAs were selected by bioinformatics analysis, and were verified by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and a
MalaCards based summary : Uterine Corpus Adenosarcoma, also known as uterine corpus mullerian adenosarcoma, is related to breast myofibroblastoma and wolffian duct adenocarcinoma. An important gene associated with Uterine Corpus Adenosarcoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Estrogen signaling pathway (KEGG) and Signaling by ERBB4. Affiliated tissues include breast, uterus and ovary ...
Uterine fibroids (aka myomas) are noncancerous growths that develop in or just outside a womans uterus (womb). Although they are composed of the same smooth muscle fibres as the uterine wall (myometrium), they are much denser than normal myometrium. Uterine fibroids develop from normal uterus muscle cells that start growing abnormally. As the cells grow, they form a benign tumour. There can either be one dominant fibroid in the uterus, or a cluster of many small fibroids. Uterine fibroids are usually round.. 20-50% of women of childbearing age have uterine fibroids. While some women do not experience any problems, those who do, can experience symptoms that require treatment.. There are four primary types of uterine fibroids classified primarily by their location within the uterus. (See below). ...
To examine the effect of the histology of carcinoma and sarcoma components on survival outcome of uterine carcinosarcoma. A multicenter retrospective study was conducted to examine uterine carcinosarcoma cases that underwent primary surgical staging. Archived slides were examined and histologic patterns were grouped based on carcinoma (low-grade versus high-grade) and sarcoma (homologous versus heterologous) components, correlating to clinico-pathological demographics and outcomes. Among 1192 cases identified, 906 cases were evaluated for histologic patterns (carcinoma/sarcoma) with high-grade/homologous (40.8%) being the most common type followed by high-grade/heterologous (30.9%), low-grade/homologous (18.0%), and low-grade/heterologous (10.3%). On multivariate analysis, high-grade/heterologous (5-year rate, 34.0%, P = 0.024) and high-grade/homologous (45.8%, P = 0.017) but not low-grade/heterologous (50.6%, P = 0.089) were independently associated with decreased progression-free survival ...
Uterine fibroids are the most common of the noncancerous (benign) tumors of the uterus. The medical term that is synonymous with uterine fibroids is leiomyoma. The cause of fibroids is unknown. However, the hormone estrogen plays a dominant role, since fibroids and associated symptoms are prevalent during the reproductive years and decline during menopause. Fibroid-related symptoms resolve during the menopause and rarely occur during puberty or adolescence. The mean age group for symptoms related to fibroid tumors is between 30 and 50 years old. The incidence of uterine fibroids ranges from 10% to 50%. Factors affecting the incidence include age, race, genetics, and family history. Luckily, most women with uterine fibroids are asymptomatic. Some fibroids may undergo cancerous (malignant) transformation, but fortunately, this is rare. In fact, leiomyosarcoma (the cancerous change of fibroids) is detected in only 0.1% of women with fibroids.. The uterus is normally about the size of a small lemon. ...
A molar pregnancy is a rare condition, which happens when there is a problem with fertilisation. Usually, an embryo gets half its genetic material (chromosomes) from the mothers egg and half from the fathers sperm. In a molar pregnancy, the wrong combination of chromosomes comes together. Sadly, this means the pregnancy cant continue and a baby cant develop.. Rarely, a molar pregnancy can also cause health problems for you. Thats because cells from a molar pregnancy can turn cancerous. It sounds scary, but this doesnt usually happen. And when it does, medical treatment is nearly always successful.. Its also reassuring to know that after a molar pregnancy, its very likely you can have a healthy pregnancy in the future.. In a complete molar pregnancy, the fathers sperm fertilises an empty egg that contains no genetic material from the mother. Sometimes two sperm fertilise the egg . It is not possible for an embryo to grow. Instead, there is a mass of abnormal tissue, which may be seen ...
Tampa Bay Areas ONLY same day outpatient center for Uterine Fibroid Embolization - Clearwater - Countryside - Palm Harbor - Tampa - St Petersburg - Largo
In a molar pregnancy, the early placenta develops into an abnormal mass (called a hydatidiform mole) that looks a little like a bunch of white grapes. The embryo either does not form at all or is malformed and cannot survive. About 1 in 1,500 pregnancies is molar.. There are two types of molar pregnancy: complete mole (there is no embryo and no normal placental tissue); and partial mole (there is an abnormal embryo, and there may be some normal placental tissue.) Both types of molar pregnancy are caused by an abnormal fertilized egg.. In a complete mole, all of the fertilized eggs chromosomes (tiny thread-like structures in cells that carry genes) come from the father. Normally, half come from the father and half from the mother. In a complete mole, shortly after fertilization, the chromosomes from the mothers egg are lost or inactivated, and those from the father are duplicated.. In most cases of partial mole, the mothers 23 chromosomes remain. However, there are two sets of chromosomes from ...
We also compare the size to weeks or months of pregnancy, since many women are familiar with this measurement. Contemporary management of uterine clinical utility of ulipristal acetate fibroid size measurements laparoscopic hysterectomy for large fibroid size measurements. It is important to remember that the size of uterine fibroids does not determine whether you will experience symptoms of uterine fibroids or not. It measures 11. Sizes of uterine fibroids vary from the size of a normal uterus which can be compared to a small pear or tennis ball to about the size of a 28 week pregnancy or the size of a pumpkin or a football. Fibroid clusters can range in size from 1 mm to more than 20 cm (8 inches) in diameter or even larger. I have 2 small uterine fibroids (my doc said the size of a pea or something) and my doctor said its very common, no big deal and just to monitor them every 6 months. To determine the efficacy of ultrasonographic assessment of uterus size in women of reproductive age, we ...
Subserosal fibroids project to the outside of the uterus. Intramural fibroids, the most common, grow in the wall of the uterus. They are the most common tumor affecting the reproductive organs and are found in up to 25% of women. 22 years experience Obstetrics and Gynecology. inhope to? Hallow Dear, Fibroids may give you pains only during menstruation. According to. Sizes of uterine fibroids vary from the size of a normal uterus which can be compared to a small pear or tennis ball to about the size of a 28 week pregnancy or the size of a pumpkin or a football. MD. You can have a single fibroid or multiple ones. Below are a few effects that can arise when fibroids grow past smaller sizes. Is it hereditary ? We may order further testing including an imaging procedure such as an ultrasound. Uterine fibroids are noncancerous growths of the uterus that often appear during childbearing years. hi, i am 38 yrs old having a fibroid of 6 5.2cm in size. UTERINE FIBROID SIZE CHART: Small (less than 1 cm â ...
Uterine leiomyomas are the most prevalent benign tumors of the reproductive tract in women. Available treatments for leiomyomas are limited to surgical procedures or hormonal therapy, which are costly and have significant side effects. In an effort to develop alternative therapeutic strategies, we tested the drug halofuginone (HF) in primary leiomyoma smooth muscle cells (LSMCs) in vitro and in vivo. Our results show that treatment of LSMCs with 50nM HF in vitro caused a significant decrease in …
If youre suffering from fibroids and the symptoms that come with it (menstrual cramping, heavy menstrual bleeding, etc.), then perhaps you need to try the natural Chinese medicine treatments of acupuncture and Chinese herbal medicine. They can reduce the size of your fibroids and eviscerate your symptoms.. Uterine fibroids are benign tumors that are also called myomas or uterine leiomyomas. Uterine fibroids are made up of connective tissue and smooth uterine muscles. This condition affects about 20 percent of women ages 35 years and over. In some women, uterine fibroids do not manifest any symptoms; in other women, they can cause signs and symptoms like pelvic pain or discomfort, painful sexual intercourse, backache (if there is compression in the nerves and muscles), urinary frequency (if there is compression in the bladder), constipation (if there is compression in the rectum), stomach bloating or discomfort, menstrual cramps, heavy menstrual bleeding, and other symptoms.. Fibroids may bring ...
This study elaborated on the significance of total hysterectomy in a cervical cancer screening population. As expected, excluding women with total hysterectomy from the target population had the greatest effect on coverage among the older women for whom the coverage increased from 72.7 to 79.4%. Even though the effect of excluding women with total hysterectomy increased with age, recalculating the coverage did not result in coverage higher than 82.7% at any age. In addition, our study showed that within the target population for cervical cancer screening, social and cultural differences were associated with having had a total hysterectomy. Women with higher socioeconomic status (higher education and higher disposable income) had lower odds of being hysterectomized compared to other women. Also, immigrants and descendants had lower odds of being hysterectomized compared to ethnic Danes.. A major strength of this study was the register-based design, minimizing the risk of both selection and ...
Uterine fibroids are common benign tumors found in the uterus. Made up of muscle tissue, they grow within the uterine wall itself or attach to it.. Uterine fibroids can cause excessive menstrual bleeding, pelvic pain, and frequent urination; fibroids potentially can cause many health problems.. According to Pubmed Health, as many as one in five women may have fibroids during their childbearing years. They grow in response to stimulation by estrogen. These growths can show up as early as age 20 but are more common for women in their thirties. They tend to shrink after menopause when the body stops producing large amounts of estrogen. Uterine fibroids can range in size, from microscopic to several inches across, filling the entire uterus and weighing tens of pounds. Fibroids grow slowly and although it is possible for just one fibroid to develop, usually there is more than one. The exact reasons why some women develop fibroids are unknown. Fibroids tend to be genetic. Affected women often have a ...
A hydatidiform mole is a pregnancy that starts with the wrong amount of genetic information (chromosomes). It is also called a molar pregnancy. Our genetic information holds the instructions for the body to grow and develop normally. The genetic information is packaged into structures called chromosomes. In humans, most cells contain 23 pairs of chromosomes, or 46 total chromosomes. The two types of molar pregnancies are called complete and partial.. In pregnancy, an egg is fertilized by the sperm. Usually, the egg and sperm each provide half of the chromosomes. In a complete molar pregnancy, the egg is missing its chromosomes. The missing information is replaced by either making a second copy of the chromosomes from the sperm or being fertilized by two sperm. The resulting pregnancy doesnt have any genetic information from the mother, only the father. Without genetic information from the mother, a baby cannot develop. The fertilized egg grows into a mass of tissue that implants in the uterus. ...
Intramural fibroids are one of the most common types of fibroids. Submucosal fibroids develop in the myometrium or the middle muscle layer of the uterus. They can grow to various sizes and occupy different parts of the uterine wall. Genetic factors: It has been observed that having a family member or more with fibroids increase ones probability of developing fibroids - suggesting a hereditary link. In some cases, fibroids can outgrow their blood supply and cause severe pain. They occur in ~25% of women of reproductive age 1and are particularly common in the African population. 4. Most fibroids are detected in a routine pelvic examination. In many women, fibroids cause no problems. Aside from the details we have already explored on the topic, here are some of the most common questions we get about uterine fibroids, and the answers to each of them: Fibroids typically look well-defined, solid masses that are firm and usually round in shape. Jun 20, 2019. The root cause of fibroids is still unknown ...
Discussing the premise of the study, lead investigator Frédéric Amant (Leuven Cancer Institute, Belgium) commented: We wanted to generate a clear view on the presence of targetable proteins in all subtypes of uterine sarcomas, with the aim of improving treatment options for these patients. Identifying biomarkers is crucial because novel treatments are expensive, underscoring the importance of patient selection.. The investigating team assessed five proteins in 288 samples of uterine sarcoma. In terms of subtypes, these samples included 157 leiomyosarcomas, 52 benign uterine stromal tumors and 41 normal uterine tissues. The remaining samples consisted of endometrial sarcomas, adenosarcomas and other undifferentiated types of uterine sarcoma.. These analyses uncovered that activated P-S6S240 is more often found expressed in high-grade tumors when compared with low-grade tumors - 32% vs 9%, respectively. Given that P-S6S240 is involved in the PI3K/mTOR cell signaling pathway, the team went on ...
Info you have to have to know about Uterine Fibroids in Ladies. What are Uterine Fibroids?. Uterine Fibroids are cells that expand from the uterine muscle. There are forms of uterine fibroids, also recognized as myocardial infarction, and can improve on the wall of the uterus and place pressure on the bladder or intestine. It can also mature within the wall of the uterus, or even arise from the wall of the uterus as a mass hanging by a slender leg into the uterine cavity or into the ectopic.. Fibroids might be as little as a pea bean or as large as a soccer ball, and they are often benign in approximation, no make a difference how large. Fibroids do not improve your chance of most cancers. If the sizing of the fibroid is plainly huge or rising on the outer area of the uterine wall, the uterus may possibly often be pushed aside. The growth of the uterus may compress the bladder or intestines.. In unusual conditions, if the fibroid is massive or if it grows in the reduce element of the uterus, ...
While experts say many forms of cancer are decreasing, federal researchers state that uterine cancer is rising. And African American women are experiencing the biggest toll of that increase.As the seventh most common fatal cancer for U.S. women, rising incidence rates of uterine cancer has garnered much medical attention. According to NBC News, the Centers for Disease Control and Prevention states the rise of obesity is closely tied with the rise of uterine cancer. Federal researchers found that rates of uterine cancer increased by 0.7 percent each year from 1999 to 2015, while death rates increased 1.1 percent each year. While uterine cancer incidence rates increased for white and Black women, Black women were twice as likely to die from the cancer than white women.. Dr. Michael Birrer, an oncologist and director of the ONeal Comprehensive Cancer Center at the University of Alabama at Birmingham, states, Theres no doubt that the incidence and mortality of uterine cancer, specifically ...
Uterine sarcoma (US) is a general term referring to rare malignancies of the uterus that originate from mesenchymal cells. US differ with regards to their histological features, growth behavior and response to therapy. Uterine carcinosarcoma, a type of mixed epithelial and mesenchymal tumor, is most frequently diagnosed. The most common uterine malignancy of solely mesenchymal origin is leiomyosarcoma. The identification of US on the basis of imaging results poses a major challenge. Therefore, many patients undergo surgery for presumed benign disease, such as leiomyoma, and the true type of tumor is only recognized after the histological examination of resected tissues.… Uterine Sarcoma: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
Mutations of mediator subcomplex 12 (MED12) and of high mobility group protein AT-hook 2 (HMGA2) are driver mutations in uterine leiomyomas (UL) that have not been observed to coexist in one tumor and even rarely coexist in different UL tumors of one patient. Here we describe a patient who underwent hysterectomy because of multiple leiomyomas which were studied by cytogenetics, MED12 hotspot sequencing, and copy number variation arrays. Two of the UL tumors had different HMGA2 rearrangements not detected by G-banding. Two UL tumors had deletions of the long arm of chromosome 3, in one case associated with a MED12 mutation. Both deletions lead to the loss of MED12L showing strong similarity with MED12. It remains to be determined if this gene can play a role in leiomyomagenesis independent of MED12. In summary, the patient presented exhibits an unusual coincidence of different driver mutations among her leiomyomas.
Fibroids are muscular tumours, the most common benign tumours in females and typically found during the middle and later reproductive years. It originate from the smooth muscle layer of the uterus. Another medical term is leiomyoma or just myoma. It can be as small as an apple seed or as big as a melon. In unusual cases they can become very large. With the advent of high frequency ultrasonography and magnetic resonance imaging it is now possible to diagnose such cases at an early stage1. Asymptomatic uterine fibroids often left untreated. Giant fibroids are the fibroids weighing 11.4kg2,3 or more. Such a fibroid may appear as a solitary tumor or as a conglomerate mass of uterine fibroids presenting as a single uterine tumor4. Giant uterine fibroid are very rare neoplasm and represents a great diagnosis and therapeutic challange. This article illustrates a case of 34 years old woman presented with a four year history of slowly increasing abdominal size with rapid increase in the last one year ...
PDCD-4 is unexpectedly elevated in leiomyomas, but normal myometrium does not express the protein; the expected inverse correlation of microRNA-21 and its target PDCD-4 is absent in fibroids.
Based on a review of 139 cases, Glasser29 found that myomectomy performed through a 3- to 6-cm minilaparotomy incision affords the advantage of same-day discharge as well as the ability to palpate the uterus and close the defect using a standard three-layered suturing technique. Those of us with uterine leiomyosarcoma are living a nightmare and may because of gynecologist who believe this fibroid non surgical removal We have a few natural remedies for fibroids for you to control any further complications in your condition, and help you heal your fibroids naturally. It aids the surgeon by allowing better visualization and handling of the fibroids.
Now that my fibroids are shrinking the doctor has stop enzymes systemic best fibroids me to get a hysterectomy and my stomach doesnt look pregnant anymore. If fibroids are causing bleeding and other side effects, you will have the option of undergoing uterine fibroid embolization at The Queens Medical Center in Honolulu, Hawaii. There is no cure for endometriosis, but there are many treatments for the pain and infertility that it causes. For more information about our services and fibroid surgery options, contact us at our Raleigh, NC gynecologist office.
If symptoms are significant, removal of the fibroids is often the best solution. Surgical treatment of fibroids can be performed in a doctors office, outpatient facility, or hospital. The type of surgery selected depends upon the location of the fibroids, their number and size, the age and general health of the patient, and whether future pregnancies are desired. Today, many procedures are done on an outpatient basis, with little recovery time necessary.. In some cases, surgery involves removing the fibroid tissue (myomectomy) with use of a laser, wire loop, freezing, or other similar method. Some fibroids can be destroyed using a procedure known as uterine fibroid embolization. In this procedure, the supply of blood to the fibroid is destroyed, causing the fibroid to shrink. If the patient is not planning a future pregnancy, fibroids can be eliminated by destroying the lining of the uterine wall (endometrial ablation) or removing the uterus (hysterectomy). Of the various methods for removing ...
"Uterine Neoplasms". Journal of the National Comprehensive Cancer Network. 7 (5): 498-531. doi:10.6004/jnccn.2009.0035. ISSN ... 2004). "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature". ... Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix. ... Nasu, K.; Takai, N.; Narahara, H. (Jun 2009). "Multimodal treatment for glassy cell carcinoma of the uterine cervix". J Obstet ...
"Peritoneal Dissemination Complicating Morcellation of Uterine Mesenchymal Neoplasms". PLoS ONE. 7 (11): e50058. doi:10.1371/ ... estimating that approximately 1 in 350 such patients is found to have an unsuspected uterine sarcoma, a type of uterine cancer ... The FDA says that it has known for some time that the morcellators could spread uterine cancer, but the recent[vague] attention ... Yuk, J. S.; Ji, H. Y.; Lee, S. H.; Park, Y. S.; Lee, J. H. (2015). "Unexpected uterine malignancy in women who have undergone ...
"Peritoneal Dissemination Complicating Morcellation of Uterine Mesenchymal Neoplasms". PLOS ONE. 7 (11): e50058. Bibcode: ... where the uterine lining has grown into and sometimes through the uterine wall musculature. This can thicken the uterine walls ... It is not effective for patients with very thick uterine lining or uterine fibroids. Levonorgestrel intrauterine devices are ... Gupta JK, Sinha A, Lumsden MA, Hickey M (December 2014). "Uterine artery embolization for symptomatic uterine fibroids". The ...
The presence of a uterine fibroid versus an adnexal tumor is made. Fibroids can be mistaken for ovarian neoplasms. An uncommon ... The prevalence of uterine fibroids among teenagers is 0.4%. The incidence of uterine fibroids in Europe is thought to be lower ... Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the uterus. Most women have ... Surgery to remove uterine fibroids occurs more frequently in women in "higher social classes". Adolescents develop uterine ...
", "creation"). A neoplasm can be benign, potentially malignant, or malignant (cancer). Benign tumors include uterine fibroids ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term "neoplasm" is a synonym of "tumor". "Neoplasia" denotes the process of the formation of neoplasms/tumors, the process ... p. Neoplasm. ISBN 978-0781733908. "II Neoplasms". International Statistical Classification of Diseases and Related Health ...
2010). "Mullerian adenosarcoma of the uterus: a rare neoplasm with a need for onco-fertility". Eur J Gynaecol Oncol. 31 (6): ... Other presentations include pelvic mass and uterine polyp. Generally, the clinical findings are non-specific. Uterine ... Uterine adenosarcoma is an uncommon form of cancer that arises from mesenchymal tissue of the uterus and has a benign glandular ... Uterine adenosarcomas are typically treated with a total abdominal hysterectomy and bilateral salpingoophorectomy (TAH-BSO). ...
The presence of a uterine fibroid versus an adnexal tumor is made. Fibroids can be mistaken for ovarian neoplasms. An uncommon ... Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the uterus.[1] Most women ... The prevalence of uterine fibroids among teenagers is 0.4%.[7]. EuropeEdit. The incidence of uterine fibroids in Europe is ... Uterine arteryEdit. Uterine artery embolization (UAE) is a noninvasive procedure that blocks of blood flow to fibroids and thus ...
Adenosarcoma Uterine adenosarcoma Zidar N, Gale N (2015). "Carcinosarcoma and spindle cell carcinoma--monoclonal neoplasms ... First, the collision tumor hypothesis, which proposes the collision of two independent tumors resulting in a single neoplasm, ... prognostic predictors and outcomes of uterine carcinosarcomas". Cancer Res Treat. 47 (2): 282-289. doi:10.4143/crt.2014.009. ...
They may include uterine bleeding not related to menstruation, pain or pressure in pelvis, large uterus and high blood pressure ...
... neoplasm, drugs, or it may be otherwise unknown.[citation needed] Diagnosis of AUB starts with a medical history and physical ... The terminology "dysfunctional uterine bleeding" is no longer recommended. Historically dysfunctional uterine bleeding meant ... The underlying causes may include ovulation problems, fibroids, the lining of the uterus growing into the uterine wall, uterine ... Abnormal uterine bleeding (AUB), also known as atypical vaginal bleeding, is vaginal bleeding from the uterus that is ...
Uterine cancer, Endometrial cancer, Ovarian cancer) Cancer of the male genital organs (Carcinoma of the penis, Prostate cancer ... A urogenital neoplasm is a tumor of the urogenital system. Types include: Cancer of the breast and female genital organs: ( ...
A neoplasm can be benign, potentially malignant, or malignant (cancer).[7]. *Benign tumors include uterine fibroids and ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term 'neoplasm' is a synonym of "tumor". 'Neoplasia' denotes the process of the formation of neoplasms/tumors, the process ... "II Neoplasms". World Health Organization. Retrieved 19 June 2014.. *^ a b Abrams, Gerald. "Neoplasia I". Retrieved 23 January ...
... neoplasm of breast 218 Uterine leiomyoma 219 Other benign neoplasm of uterus 220 Benign neoplasm of ovary 221 Benign neoplasm ... 140 Malignant neoplasm of lip 141 Malignant neoplasm of tongue 142 Malignant neoplasm of major salivary glands 143 Malignant ... neoplasm of oropharynx 147 Malignant neoplasm of nasopharynx 148 Malignant neoplasm of hypopharynx 149 Malignant neoplasm of ... except isthmus Endometrial cancer 183 Malignant neoplasm of ovary and other uterine adnexa 184 Malignant neoplasm of other and ...
Gynoroentgenologic imaging can detect and diagnose primary neoplasms, metastasis, therapy-related lesions, congenital lesions, ... inflammation, miscellaneous diseases, pseudolesions, normal variants, infection uterine arteriovenous malformations and cystic ...
Uterine fibroids are leiomyomata of the uterine smooth muscle. As other leiomyomata, they are benign, but may lead to excessive ... Mesenchymal neoplasms of the gallbladder are rare and in particular leiomyomas of the gallbladder have been rarely reported, ... Uterine lipoleiomyomata have been observed together with ovarian and other pathologies and some of them may develop into ... A rare form of these tumors is uterine lipoleiomyoma-benign tumors consisting of a mixture of adipocytes and smooth muscle ...
... such as pre-cancerous lesions of the uterine cervix. Benign neoplasms are typically but not always composed of cells which bear ... Common examples of benign tumors include moles and uterine fibroids. Although benign tumors will not metastasize or locally ... ISBN 92-832-2416-7. Gill SS, Heuman DM, Mihas AA (October 2001). "Small intestinal neoplasms". J. Clin. Gastroenterol. 33 (4): ... polyps of the colon are often referred to as benign but they are actually overgrowths of normal tissue rather than neoplasms. ...
They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... Colon, uterine, small bowel, stomach, urinary tract Genetic testing for individuals at high-risk of certain cancers is ... In a few instances, such as advanced uterine cancer, the pregnancy cannot be continued and in others, the patient may end the ...
... and Uterine Corpus Endometrial Carcinoma. MORT is silenced in cervical cancer and therefore may serve as an independent ... lymphoid neoplasm diffuse large B-cell lymphoma, pancreatic adenocarcinoma, rectum adenocarcinoma, skin cutaneous melanoma, ...
Immunohistochemistry may help in diagnosing Krukenberg tumors from primary ovarian neoplasms but needs to be applied with ... ampulla of Vater or uterine cervix. ...
Bleeding due to a ruptured ectopic pregnancy or uterine rupture. Rupture of corpus luteum in some cases. Less commonly, ... Bleeding due to rupture of an intra-abdominal neoplasm, (e.g., Hepatoblastoma) Disseminated intravascular coagulation People on ...
Uterine cavity Fundus The uterus has three layers, which together form the uterine wall. From innermost to outermost, these ... malignant neoplasm Fibroids - benign neoplasms Adenomyosis - ectopic growth of endometrial tissue within the myometrium ... most commonly seen in dogs Uterine malformations mainly congenital malformations including Uterine Didelphys, bicornuate uterus ... During pregnancy, the uterine glands and blood vessels in the endometrium further increase in size and number and form the ...
It appears in the sex cord-stromal tumour group of ovarian neoplasms. Ovary fibromas are most frequent during middle age, and ... uterine fibroma, etc. The neurofibroma is a benign nerve-sheath tumor in the peripheral nervous system. ...
"Deletion 7q22 in uterine leiomyoma. A cytogenetic review". Cancer Genetics & Cytogenetics 1993, 71(1):1-6. Zeng WR, Scherer SW ... "Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression". Blood 2011, 118:167-76. ... "Identification of CUX1 as the recurrent chromosomal band 7q22 target gene in human uterine leiomyoma". Genes, Chromosomes & ... and KRAS in uterine leiomyomas". Molecular Carcinogenesis 2003, 37:61-4. Moon NS, Rong Zeng W, Premdas P, Santaguida M, Berube ...
... s or theca cell tumors are benign ovarian neoplasms composed only of theca cells. Histogenetically they are classified ... of patients present with abnormal uterine bleeding, and 20% have endometrial carcinoma. Grossly, the tumour is solid and yellow ...
It is likely directly induced by an underlying neoplasm secreting a growth factor. One candidate may be alpha-transforming ... uterine cancer, prostate cancer[citation needed], lung cancer and cervical cancer. Other associated underlying malignancies ...
Janeway's 1919 paper on "The Treatment of Uterine Carcinoma" was considered a classic and was written while he was Attending ... A Model for a Curable Neoplasm" 2010 Charles M. Balch, M.D., Johns Hopkins Medical Institute - "Melanoma as an Example of ... Janeway, M.D., Henry H. (September 1919). "The Treatment of Uterine Cancer by Radium". Surgery, Gynecology, and Obstetrics. 24 ... Janeway's work with radium in uterine cancer was most notable. He was the first man in this country to advocate radium as the ...
Additionally, hematometra may develop as a complication of uterine or cervical surgery such as endometrial ablation, where scar ... a biopsy of endometrial tissue can be taken to test for the presence of a neoplasm (cancer). Antibiotics may be given as ... which will show blood pooled in the uterus and an enlargement of the uterine cavity. A pyelogram or laparoscopy may assist in ... sections of endometrial glands and stroma causing blood to accumulate in the uterine cavity. It can also develop after abortion ...
Uterine adenosarcoma are a subtype of uterine sarcomas. Uterine sarcomas account for 3 to 9 % of uterine cancers, and 5.5 to 9 ... Malignant neoplasms arising in endometriosis: clinicopathological study of 14 cases. Clin Exp Obstet Gynecol. 2004;31(4):302-4 ... Uterine adenosarcoma commonly arise from the endometrium. Uterine adenosarcomas have the highest incidence in perimenopasual ... Survival is better compared to other types of uterine sarcomas. The prognosis of uterine adenosarcoma depends on the stage and ...
This may be followed by the development of a malignant neoplasm. Dyskaryosis is used synonymously with dysplasia, which is the ... ". "Dyskaryosis" is a term used for all squamous mucosal surfaces and commonly used for the uterine cervix condition in which ...
... uterine rupture MeSH C21.866.761.853.500 - uterine perforation MeSH C21.866.797.240 - crush syndrome MeSH C21.866.819.339 - ... neoplasms, radiation-induced MeSH C21.866.733.579 - osteoradionecrosis MeSH C21.866.733.720 - radiation injuries, experimental ...
Myung SK, Ju W, Kim SC, Kim H (October 2011). "Vitamin or antioxidant intake (or serum level) and risk of cervical neoplasm: a ... Schlaerth JB, Spirtos NM, Schlaerth AC (January 2003). "Radical trachelectomy and pelvic lymphadenectomy with uterine ... with biopsies of the remaining lower uterine segment as needed (every 3-4 months for at least 5 years) to monitor for any ... "Association of educational levels with survival in Indian patients with cancer of the uterine cervix". Asian Pacific Journal of ...
Extra-uterine pregnancy. D. Appleton, 189 pp. Encyclopédie, Ou Dictionnaire Universel Raisonné Des Connoissances Humaines: Con ... "Old abdominal pregnancy presenting as an ovarian neoplasm". Journal of Korean Medical Science. 17 (2): 274-75. doi:10.3346/jkms ...
They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... In a few instances, such as advanced uterine cancer, the pregnancy cannot be continued and in others, the patient may end the ...
CD10+ differentiates mucinous cystic neoplasms (CD10+/CK20+) from intraductal papillary mucinous neoplasm of branch duct type ( ... Müllerian adenosarcoma Uterine high-grade leiomyosarcoma Uterine rhabdomyosarcoma Vascular tumors Epithelioid ... Murali R, Delprado W (2005). "CD10 immunohistochemical staining in urothelial neoplasms". Am. J. Clin. Pathol. 124 (3): 371-9. ... and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms". ...
... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... Multinucleate cell angiohistocytoma Multiple cutaneous and uterine leiomyomatosis syndrome (leiomyomatosis cutis et uteri, ... an overview with emphasis on the myeloid neoplasms". Chem. Biol. Interact. 184 (1-2): 16-20. doi:10.1016/j.cbi.2009.10.009. ... neoplasms invading or aberrantly present in the dermis. Acquired progressive lymphangioma (benign lymphangioendothelioma) Acral ...
Shimizu T, Hatanaka K, Kaneko H, Shimada T, Imada K (July 2017). "Primary uterine diffuse large B-cell lymphoma (DLBCL) in a ... An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation". The ...
Uterine artery embolization (UAE) or uterine fibroid embolization (UFE) Prostate artery embolization (PAE) Pulmonary ... such as osteoporosis or underlying neoplasm. Analogous to vertebroplasty, the purpose of sacroplasty is to provide ...
... genital neoplasms, female MeSH C04.588.945.418.365 - fallopian tube neoplasms MeSH C04.588.945.418.948 - uterine neoplasms MeSH ... uterine cervical neoplasms MeSH C04.588.945.418.955 - vaginal neoplasms MeSH C04.588.945.418.968 - vulvar neoplasms MeSH ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ...
... cancer of the uterine lining) are possible, due to overaccumulation of uterine lining, and also lack of progesterone resulting ... androgen secreting neoplasms, and other pituitary or adrenal disorders, should be investigated. The primary treatments for PCOS ... in prolonged stimulation of uterine cells by estrogen. It is not clear whether this risk is directly due to the syndrome or ...
"Pharmacology and Clinical Utility of Hormones in Hormone Related Neoplasms". In Alan C. Sartorelli, David G. Johns (eds.). ... in treatment of infertility in women when there is a need to develop sperm-friendly cervical mucous or an appropriate uterine ...
... uterine cervical neoplasms MeSH C13.371.852.833 - uterine prolapse MeSH C13.371.852.904 - uterine rupture MeSH C13.371.852.904. ... uterine cervical neoplasms MeSH C13.371.820.800.418.937 - vaginal neoplasms MeSH C13.371.820.800.418.968 - vulvar neoplasms ... uterine inversion MeSH C13.371.852.762 - uterine neoplasms MeSH C13.371.852.762.200 - endometrial neoplasms MeSH C13.371. ... uterine cervical incompetence MeSH C13.371.852.150.131 - uterine cervical neoplasms MeSH C13.371.852.150.150 - uterine ...
Frick J, Marberger H, Swoboda HP (May 1971). "[Hormone therapy of prostatic neoplasms]". Urologe (in German). 10 (3): 117-9. ... Gruber TJ, Fabiano AJ, Deeb G, Lele SB, Fenstermaker RA (November 2011). "Intracranial meningiomas in patients with uterine ...
They are part of the surface epithelial tumor group of ovarian neoplasms (10-20% of which are the endometrioid type). Benign ... Mendivil, Alberto; Schuler, Kevin M.; Gehrig, Paola A. (2009). "Non-Endometrioid Adenocarcinoma of the Uterine Corpus: A Review ...
... neoplasm seeding MeSH C23.550.727.650.895 - neoplasms, unknown primary MeSH C23.550.727.655 - neoplasm recurrence, local MeSH ... uterine hemorrhage MeSH C23.550.414.993.700 - metrorrhagia MeSH C23.550.414.993.850 - postpartum hemorrhage MeSH C23.550. ... neoplasm metastasis MeSH C23.550.727.650.560 - lymphatic metastasis MeSH C23.550.727.650.645 - neoplasm circulating cells MeSH ... C23.550.727.670 - neoplasm regression, spontaneous MeSH C23.550.727.700 - neoplasm, residual MeSH C23.550.737.500 - retrograde ...
Ischemic placental disease leads to the attachment of the placenta to the uterine wall to become under-perfused, causing ... vasculopathy Hypertrophic decidual vasculopathy Chorangiosis Chorangioma Placental infarction Trophoblastic neoplasms derive ... Moreover, being exposed to severe trauma within the pregnancy period, rapid acceleration and deceleration and uterine ...
List of cutaneous neoplasms associated with systemic syndromes Mester J, Eng C (January 2015). "Cowden syndrome: recognizing ... Currently, it is not clear whether uterine leiomyomata (fibroids) or congenital genitourinary abnormalities occur at an ... uterine, and other cancers. It is often underdiagnosed due to variability in disease presentation, but 99% of patients report ...
Malignant neoplasms, other cutaneous neoplasms with significant vascular component, and disorders erroneously considered as ... It may also occur in the lower limbs or groin after surgery for colon, ovarian or uterine cancer, in which removal of lymph ... Hirabayashi S, Wlodarski MW, Kozyra E, Niemeyer CM (August 2017). "Heterogeneity of GATA2-related myeloid neoplasms". ... vascular neoplasms". Journal of the American Academy of Dermatology. 38 (2 Pt 1): 143-75, quiz 176-8. doi:10.1016/S0190-9622(98 ...
Uterine bleeding. Pain during or shortly after beginning or end of menstrual period; irregular periods, or abnormal uterine ... The presence of multiloculation suggests a neoplasm, although the thin septation implies that the neoplasm is benign. For any ...
Intravascular leiomyomatosis is a benign neoplasm that extends through the veins; angioleiomyoma is a benign neoplasm of the ... In the uterus, a shift in myosin expression has been hypothesized to avail for changes in the directions of uterine ... "Physiological pathways and molecular mechanisms regulating uterine contractility". Hum. Reprod. Update. 16 (6): 725-44. doi: ... extremities; vascular leiomyosarcomas is a malignant neoplasm that can be found in the inferior vena cava, pulmonary arteries ...
The narrow, central cervical canal runs along its entire length, connecting the uterine cavity and the lumen of the vagina. The ... Papillary - In oncology, papillary refers to neoplasms with projections ("papillae", from Latin, 'nipple') that have ... The uterus also produces vaginal and uterine secretions which help the transit of sperm to the Fallopian tubes. The ovaries ... Fallopian tube - The Fallopian tubes, also known as uterine tubes or salpinges (singular salpinx), are tubes that stretch from ...
... transitional cell cancer Urethral cancer Uterine sarcoma Vaginal cancer Vulvar cancer Wilms tumor Esophageal cancer Head and ... Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm ...
Besides placenta previa and placental abruption, uterine rupture can occur, which is a very serious condition leading to ... neoplasm, most commonly cervical cancer, and hematologic disorders. Molar pregnancy (also called hydatiform mole) is a type of ... Causes of bleeding before and during childbirth include cervicitis, placenta previa, placental abruption and uterine rupture. ...
All MeSH CategoriesDiseases CategoryNeoplasmsNeoplasms by SiteUrogenital NeoplasmsGenital Neoplasms, FemaleUterine Neoplasms ... FemaleUterine DiseasesUterine NeoplasmsUterine Cervical Neoplasms. All MeSH CategoriesDiseases CategoryFemale Urogenital ... FemaleUterine DiseasesUterine Cervical DiseasesUterine Cervical Neoplasms. All MeSH CategoriesDiseases CategoryFemale ... Diseases and Pregnancy ComplicationsFemale Urogenital DiseasesUrogenital NeoplasmsGenital Neoplasms, FemaleUterine Neoplasms ...
1. Cancer is an emerging public health problem in the WHO African Region. According to Globocan,1 there were 582 000 new cancer cases in sub-Saharan Africa in 2002. The commonest cancers in men are Kaposis sarcoma and ...
Pfizer is currently recruiting for the NCT00136955 Uterine Cervical Neoplasms Cancer trial. Review trial description, criteria ...
Search of: Recruiting, Not yet recruiting, Available Studies , Uterine Neoplasms - Modify Search. Fill in any or all of the ...
... neoplasms and show that array-based DNA methylation analysis holds promise as an ancillary tool to further characterize uterine ... neoplasms, especially in cases which are diagnostically challenging by conventional techniques.... ... we describe distinct DNA methylation signatures in uterine ... DNA methylation-based profiling of uterine neoplasms: a novel ... ConclusionHerein, we describe distinct DNA methylation signatures in uterine neoplasms and show that array-based DNA ...
"Uterine Cervical Neoplasms" by people in this website by year, and whether "Uterine Cervical Neoplasms" was a major or minor ... "Uterine Cervical Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Uterine Cervical Neoplasms" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Uterine Cervical Neoplasms". ...
Benign neoplasm of uterine tubes and ligaments. 2016 2017 2018 Billable/Specific Code Female Dx *D28.2 is a billable/specific ... 742 Uterine and adnexa procedures for non-malignancy with cc/mcc. *743 Uterine and adnexa procedures for non-malignancy without ... Malignant neoplasm of ectopic tissue. *Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ... Neoplasms. Note*Functional activity. *All neoplasms are classified in this chapter, whether they are functionally active or not ...
Uterine Neoplasms Clinical Practice Guidelines in Oncology NCCN Categories of Evidence and Consensus Category 1: The ... Tumors of the uterine corpus. In: Pazdur R, ed. Medical Oncology: A Comprehensive Review. Huntington: PRR; 1996:407-416. ... For patients with suspected uterine neoplasms, initial preoperative evaluation includes a history and physical examination, ... An estimated 40,100 new diagnoses of uterine cancer and 7470 deaths from this disease will occur in 2008.1 Uterine sarcomas are ...
Uterine tumours resembling ovarian sex cord tumours (UTROSCTs) are rare primary uterine neoplasms which morphologically ... Figure 1​1 illustrates examples of the histology of the neoplasms.. Figure 1. Uterine tumour resembling ovarian sex cord tumour ... 3. Baker R J, Hildebrandt R H, Rouse R V. et al Inhibin and CD99(MIC2) expression in uterine stromal neoplasms with sex‐cord‐ ... 7. Irving J A, Carinelli S, Prat J. Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
MalaCards integrated aliases for Uterine Benign Neoplasm:. Name: Uterine Benign Neoplasm 12 15 ... Uterine Benign Neoplasm is related to endometrial hyperplasia and leiomyoma, uterine. An important gene associated with Uterine ... MalaCards organs/tissues related to Uterine Benign Neoplasm:. 40 Breast, Uterus, Ovary, Tongue, Bone, Thyroid, Skin ... Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:. (show all 18) #. Super pathways. Score ...
西太平洋区域委员会, 061 (马尼拉:世卫组织西太平
Updates and management algorithm for neuroendocrine tumors of the uterine cervix Gloria Salvo, Antonio Gonzalez Martin, Naomi R ...
This is an ecological study of a cross-sectional cohort and time series of deaths from uterine cancer that were recorded on the ... The aim of this study was to analyze the trend in mortality from uterine neoplasms and their risk factors, specified by the ...
Uterine Neoplasms -- surgery ✖Remove constraint Subjects: Uterine Neoplasms -- surgery Genre Case Reports ✖Remove constraint ... Uterine Neoplasms -- surgery. Dilatation and Curettage. 4. A successful case of laparo-hysterectomy for uterine fibroids ... Uterine Neoplasms -- surgery. Leiomyoma -- surgery. Uterine Inversion -- surgery. 7. A case of fibrous tumor of the uterus: ... Uterine Neoplasms -- surgery. Electrolysis. 3. An experience with sloughing intra-uterine fibroids ...
Uterine. Cervical. Neoplasms. */diagnosis Uterine. Cervical. Neoplasms. */metabolism Uterine. Cervical. Neoplasms. */pathology ... Uterine. Cervical. Neoplasms. /epidemiology ; Uterine. Cervical. Neoplasms. /prevention & control ; Young Adult. Czasopismo ... Uterine. Cervical. Neoplasms. /*diagnosis Uterine. Cervical. Neoplasms. /*prevention & control Vaginal Smears. /*psychology. ... Uterine. Cervical. Neoplasms. /mortality ; Uterine. Cervical. Neoplasms. /virology ; Young Adult. Czasopismo naukowe ...
Uterine Neoplasms. Cervix Neoplasms. Uterus. Cervix Uteri. Part of Book Anatomie pathologique du corps humain, descriptions ... Uterine neoplasms, shown in isolation, in 2 numbered illustrations. Uterus dissected to show neoplasms. 1 illustration of ... prolapsed cervix with neoplasms.. General Note(s) Plate signed by the artist, A. Chazal; printed by Delaporte. Part of the book ...
Color atlas of uterine cancer cytology / Franz A. Iklé, Yi-Jing Shu.. by Iklé, Franz Anton , Shu, Yi-Jing ...
... and ovaries and sample the lymph nodes is the main treatment for uterine sarcomas. ... Uterine Neoplasms. Version 1.2018 -- October 13, 2017. Ricci S, Stone RL, Fader AN. Uterine leiomyosarcoma: Epidemiology, ... Treatment for Uterine Sarcoma, by Type and Stage. Surgery to remove the uterus, sometimes along with the fallopian tubes and ... For uterine sarcoma, the cancer growing back as a tumor in the pelvis would be a local recurrence. If it comes back in another ...
... more frequently develops in the muscle tissue layer of the uterine body than in the uterine cervix. The development of ... A diagnostic biomarker: differential expression of LMP2/β1i in human uterine neoplasms. Uterine leiomyosarcoma (Ut-LMS) more ... frequently develops in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecological ...
Uterine Neoplasms / diagnosis. Uterine Neoplasms / therapy. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / therapy ... Neoplasm Invasiveness. Pregnancy. Uterine Neoplasms / pathology. Uterine Neoplasms / surgery. *MedlinePlus Health Information. ... Uterine Cervical Neoplasms / drug therapy. Uterine Neoplasms / drug therapy. Vaginal Neoplasms / drug therapy ... Neoplasm Staging / methods. Positron-Emission Tomography / methods. Uterine Neoplasms / pathology. Uterine Neoplasms / ...
Uterine cancer is cancer of the uterus. The most common type, endometrial cancer, happens most often in women over 55. Know the ... ClinicalTrials.gov: Endometrial Neoplasms (National Institutes of Health) * ClinicalTrials.gov: Uterine Neoplasms (National ... General Information About Uterine Sarcoma (National Cancer Institute) Also in Spanish * What Is Uterine Sarcoma? (American ... Uterine Cancer Statistics (Centers for Disease Control and Prevention) * What Are the Key Statistics about Uterine Sarcoma? ( ...
Uterine Cervical Neoplasms. Uterine Neoplasms. Genital Neoplasms, Female. Urogenital Neoplasms. Neoplasms by Site. Neoplasms. ...
If your institution subscribes to this resource, and you dont have a MyAccess Profile, please contact your librarys reference desk for information on how to gain access to this resource from off-campus. Learn More ...
This and other studies suggest that uterine tumors classified as STUMPs using criteria proposed by Stanford investigators are ... Neoplasm Recurrence, Local / epidemiology * Neoplasm Recurrence, Local / pathology * Receptors, Estrogen / biosynthesis * ... Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases Am J Surg ... Background: The current World Health Organization classification indicates that a uterine smooth muscle tumor that cannot be ...
Uterine Neoplasms. D014594. EFO:0003859. uterine neoplasm. 2. ClinicalTrials. Digestive System Diseases. D004066. EFO:0000405. ... Stomach Neoplasms. D013274. EFO:0000503. gastric adenocarcinoma. 3. ClinicalTrials. Uterine Cervical Neoplasms. D002583. EFO: ... Stomach Neoplasms. D013274. EFO:0003897. stomach neoplasm. 3. ClinicalTrials. Anus Neoplasms. D001005. EFO:0003835. anal ... Peritoneal Neoplasms. D010534. EFO:1001100. peritoneal neoplasm. 2. ClinicalTrials. Rectal Neoplasms. D012004. EFO:1000657. ...
  • So far, though, the value of adjuvant treatments for uterine sarcoma isn't clear. (cancer.org)
  • Because uterine sarcoma is rare, it's has been hard to study it well. (cancer.org)
  • Most experts agree that treatment in a clinical trial should be considered for any type or stage of uterine sarcoma. (cancer.org)
  • How Is Uterine Sarcoma Staged? (medlineplus.gov)
  • Can Uterine Sarcoma Be Found Early? (medlineplus.gov)
  • What Are the Risk Factors for Uterine Sarcoma? (medlineplus.gov)
  • What Should You Ask Your Doctor about Uterine Sarcoma? (medlineplus.gov)
  • What Is Uterine Sarcoma? (medlineplus.gov)
  • What Are the Key Statistics about Uterine Sarcoma? (medlineplus.gov)
  • What's New in Uterine Sarcoma Research and Treatment? (medlineplus.gov)
  • It does not cover cancer in the muscle of the uterus, which is called uterine sarcoma. (northshore.org)
  • [11] In the same statement the FDA discouraged the use of power morcellators in patients seeking hysterectomy (removal of uterus through lower abdomen) and myomectomy (surgery to remove uterine fibroids - also called leiomyomas) procedures, estimating that approximately 1 in 350 such patients is found to have an unsuspected uterine sarcoma, a type of uterine cancer that includes leiomyosarcoma. (wikipedia.org)
  • Treatment of uterine carcinosarcoma and uterine sarcoma , 8. (bvsalud.org)
  • Treatment for uterine sarcoma , 9. (bvsalud.org)
  • Another type of uterine cancer is sarcoma of the uterus. (oncolink.org)
  • With uterine sarcoma, cancer is within the uterine muscle. (oncolink.org)
  • Uterine sarcoma is very rare, with an estimated 1600 cases annually. (oncolink.org)
  • There are several subtypes of uterine sarcomas, including low grade endometrial stromal sarcoma (ESS), high grade ESS, undifferentiated uterine sarcoma (UUS) and uterine leiomyosarcoma (ULMS). (oncolink.org)
  • There are also rare uterine mesenchymal sarcoma subtypes, including adenosarcoma, perivascular epitheliod cell tumor (PEComa) and rhabdomyosarcoma. (oncolink.org)
  • Treatment for these rare uterine sarcomas often follow guidelines for soft tissue sarcoma . (oncolink.org)
  • Uterine Benign Neoplasm is related to endometrial hyperplasia and leiomyoma, uterine . (malacards.org)
  • Extensive iliac vein thrombosis as a rare complication of a uterine leiomyoma: a case report. (biomedsearch.com)
  • BACKGROUND: Lower leg thombosis can occur in association with a large uterine leiomyoma. (biomedsearch.com)
  • Treatment strategies for uterine leiomyoma: the role of hormonal modulation. (medigraphic.com)
  • 12 A female reproductive organ benign neoplasm that is located in the uterus. (malacards.org)
  • Uterus dissected to show neoplasms. (utoronto.ca)
  • Surgery to remove the uterus, sometimes along with the fallopian tubes and ovaries and to check the lymph nodes, is the main treatment for all uterine sarcomas. (cancer.org)
  • Endometrial cancer is also called cancer of the uterus, or uterine cancer. (northshore.org)
  • Fibroids (also called uterine myomas) are very common benign tumors of the muscle of the uterus (myometrium). (oncolink.org)
  • At the time of the uterine specimen (uterine fibroid or uterus itself) removal from the abdominal cavity, the surgical specimen is frequently too large to be extracted through the routes used to access the surgical field without impairing the tissue integrity. (frontiersin.org)
  • Tumors or cancer of the UTERINE CERVIX. (nih.gov)
  • For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned. (icd10data.com)
  • This and other studies suggest that uterine tumors classified as STUMPs using criteria proposed by Stanford investigators are usually clinically benign but should be considered tumors of low malignant potential because they can occasionally recur, in some cases, years after hysterectomy. (nih.gov)
  • Given these favorable preliminary findings, supported by recently published data documenting efficacy of the "sandwich" multimodality technique in other difficult uterine malignancies (malignant mixed mullerian tumors), we propose to study this combination of chemotherapy and radiation prospectively. (knowcancer.com)
  • This is the case for the group of tumors sometimes referred to as endocrine-related cancer, which includes tumors arising from endocrine organs, for example, thyroid cancer and neuroendocrine tumors, and those tumors whose parent tissue responds to endocrine signaling, including breast, prostate, and uterine cancers. (snmjournals.org)
  • Treatment for uterine carcinosarcoma , 8. (bvsalud.org)
  • TNP-470 inhibits growth and the production of vascular endothelial growth factor of uterine carcinosarcoma cells in vitro. (curehunter.com)
  • Impact of multimodal therapy on the survival of patients with newly diagnosed uterine carcinosarcoma. (curehunter.com)
  • To investigate treatment outcomes of uterine carcinosarcoma (CS) patients who underwent complete surgical resection of all visible disease and platinum -based adjuvant chemotherapy (multimodal therapy). (curehunter.com)
  • Adenocarcinoma of the uterine cervix metastatic to lymph nodes. (healthtap.com)
  • 2004). "Glassy cell carcinoma of the uterine cervix a rare histology. (wikipedia.org)
  • MR is a relatively promising method for staging and evaluating extent of disease in carcinoma of the uterine cervix. (koreamed.org)
  • A series of investigations on ovarian neoplasms have improved our understanding of proinflammatory microenvironment including unfavorable cytokines, chemokines and imbalanced hormone production. (mdpi.com)
  • The Fourth Edition of the Guidelines for Treatment of Uterine Body Neoplasm was published in 2018. (bvsalud.org)
  • Treatment of uterine leiomyomas. (medigraphic.com)
  • Systematic review of mifepristone for the treatment of uterine leiomyomata. (medigraphic.com)
  • Endometrial cancer is the most common type of uterine cancer. (medlineplus.gov)
  • The current World Health Organization classification indicates that a uterine smooth muscle tumor that cannot be histologically diagnosed as unequivocally benign or malignant should be termed "smooth muscle tumor of uncertain malignant potential" (STUMP). (nih.gov)
  • Our findings provide a broad overview of molecular events underlying the tumorigenesis of uterine ULMs and identify select genetic and regulatory events that alter microRNA expression and may play important roles in ULM pathobiology by positively regulating tumor growth while maintaining the non-invasive character of ULMs. (nih.gov)
  • Heterogeneity in the host hormonal milieu and in the ability of uterine leiomyomas to respond to various hormones may be important factors contributing to the wide variation in growth potential observed in leiomyomas. (nih.gov)
  • CONCLUSION: In women with large uterine leiomyomas, the preoperative workup should include testing to rule out potential asymptomatic thrombi. (biomedsearch.com)
  • Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas. (nih.gov)
  • Human uterine leiomyomas (ULM) are characterized by dysregulation of a large number of genes and non-coding regulatory microRNAs. (nih.gov)
  • A benefit-risk assessment of medical treatment for uterine leiomyomas. (medigraphic.com)
  • Workup revealed extensive thrombosis involving iliac, femoral, popliteal, posterior tibial and peroneal veins secondary to vena caval compression by large uterine fibroids. (biomedsearch.com)
  • Uterine fibroids. (medigraphic.com)
  • An evidencebased guideline for the management of uterine fibroids. (medigraphic.com)
  • Uterine fibroids: the elephant in the room. (medigraphic.com)
  • An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer . (malacards.org)
  • We have especially focused on the immunophenotype of these neoplasms and have undertaken an extensive immunohistochemical analysis, using markers of epithelial, myoid, sex cord and neuroendocrine lineage as well as hormone receptors. (pubmedcentralcanada.ca)
  • Disponible en http://stke.sciencemag.org/cgi/content/abstract/sci;308/5728/1589. (medigraphic.com)
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified ( C25.9 ). (icd10data.com)
  • Uterine Cervical Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Uterine leiomyosarcoma (Ut-LMS) more frequently develops in the muscle tissue layer of the uterine body than in the uterine cervix. (scitechnol.com)
  • To describe the clinicopathological and immunohistochemical findings in four cases of uterine tumour resembling ovarian sex cord tumour (UTROSCT). (pubmedcentralcanada.ca)
  • Thirty cases of uterine neoplasms were treated with TCM acupoint sticking at Guanyuan (CV 4), Qihai (CV 6) and Zhongji (CV 3), and Sanleng (Rhizoma Sparganii), E'zhu (Rhizoma Zedoarise) and Dahuang (Radix et Rhizoma Rhei), etc. were used. (bvsalud.org)
  • Predicted target genes or microRNAs in uterine ULMs.A Predicted target genes for the 5 most highly upregulated (left) and 5 most highly downregulated microRNAs (right). (nih.gov)
  • CASE: We report a case of extensive lower extremity thromboembolic disease secondary to large uterine myomas. (biomedsearch.com)
  • Uterine synechiae after bipolar hysteroscopic resection of submucosal myomas in patients with infertility. (biomedsearch.com)
  • Since April 2014 the Food and Drug Administration (FDA) has discouraged its use for uterine procedures, issuing a warning that morcellators may spread occult cancer in the course of fibroid removal. (wikipedia.org)
  • Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix. (wikipedia.org)
  • We searched the PubMed, EMBASE, and Cochrane Library databases for published studies from inception to August 2014, using terms such as 'endometrial cancer' or 'uterine cancer' for disease, 'omentectomy' or 'omental biopsy' for intervention, and 'metastasis' for outcome. (springer.com)
  • Uterine papillary serous carcinoma (UPSC) is an uncommon, but aggressive variant of endometrial carcinoma that has a high recurrence rate and poor response to therapy. (knowcancer.com)
  • 1. Histologically documented uterine papillary serous carcinoma (UPSC) with no visible residual disease. (knowcancer.com)
  • This procedure can be done to determine presence of any abnormal uterine mass which may be an indication of cancer. (medlineplus.gov)
  • Hydroxyprogesterone may also be used to treat amenorrhea (lack of menstruation), advanced uterine cancer, and abnormal bleeding due to an imbalance of the hormones. (medicineshoppe.com)
  • Uterine Neoplasms Clinical Practice Guidelines in Oncology NCCN Categories of Evidence and Consensus Category 1: The recommendation is based on high-level evidence (e.g., randomized controlled trials) and there is uniform NCCN consensus. (jnccn.org)
  • To probe into clinical therapeutic effect of TCM acupoint sticking on uterine neoplasms . (bvsalud.org)
  • MAIN OUTCOME MEASURE(S): The formation of uterine synechiae and pregnancy rates were collected from the patients' clinical notes. (biomedsearch.com)
  • So if there is an oncologist who treats a lot of metastatic uterine cancer, his office may know how to word the appeal so that it would be covered. (cancer.org)