Pancreatic Neoplasms
Hybrid capture II, a new sensitive test for human papillomavirus detection. Comparison with hybrid capture I and PCR results in cervical lesions. (1/6661)
AIM: To test a new assay for the detection of human papillomavirus (HPV) DNA, hybrid capture II (HC II), compared with the previous commercialized hybrid capture I (HC I) and polymerase chain reaction (PCR) results on cervical scrapes from fresh cone excision biopsy samples. METHODS: The three methods were used on cervical scrapes from 42 fresh cone excision biopsy samples. There were nine metaplastic and inflammatory lesions, five low grade lesions, and 28 high grade lesions. PCR was performed using the general primers GP5+/GP6+. The viral load of high risk HPV DNA was estimated by the ratio of relative light units to positive control values in the samples. RESULTS: The sensitivity of HC I for the detection of high grade lesions was 71.4%, while it was 92.8% for HC II and 96.4% for the PCR. Considering only the absence of detectable cervical in situ neoplasia, the specificity was 88.9% for HC I, 66.7% for HC II, and 66.7% for PCR. With HC II, for a ratio of cervical sample to normal control of > 200, the sensitivity for the detection of high grade lesion was only 34.6% with a specificity of 66.7%. CONCLUSIONS: HPV detection with the HC II assay is more sensitive than the previous HC I and represents a more convenient and easier test than PCR for routine use. Nevertheless the viral load estimated with this test cannot be a reliable predictive indicator of high grade lesions. (+info)Immunohistochemical expression of mdm2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. (2/6661)
AIM: To investigate the immunocytochemical staining pattern of mdm2 and p21WAF1 proteins in invasive cervical cancer and to determine its relation with the expression of p53 and with the high risk HPV infection. METHODS: Immunocytochemistry for p53, mdm2, and p21WAF1 was performed in 31 paraffin embedded sections of invasive cervical cancer. The results were assessed by image analysis, evaluating for each protein the optical density of the immunostained area, scored as percentage of the total nuclear area. The presence of high risk human papillomavirus (HPV) infection was detected by using the polymerase chain reaction. RESULTS: Immunostaining for both mdm2 and p21WAF1 was correlated with p53 expression; however, the correlation between p53 and mdm2 (R = 0.49; p < 0.01) was more significant than between p53 and p21WAF1 (R = 0.31; p < 0.05); the less stringent correlation between p53 and p21WAF1 might reflect the p53 independent mechanisms of p21WAF1 induction. Similar average levels of p53, mdm2, and p21WAF1 immunostaining were found in the presence or absence of high risk HPV-DNA, without significant differences between the two groups. CONCLUSIONS: These data suggest that mdm2 and p21WAF1 proteins are expressed in invasive cervical cancer and that their immunocytochemical staining pattern is not abrogated by the presence of high risk HPV genomic sequences. (+info)Expression of extracellular matrix proteins in cervical squamous cell carcinoma--a clinicopathological study. (3/6661)
AIM: To evaluate the intracellular and peritumoral expression of matrix proteins in squamous cell carcinoma of the uterine cervix using immunohistochemistry. METHODS: 71 squamous cell carcinomas and 10 controls were stained for laminin, fibronectin, and collagen IV. Cytoplasmic staining in tumour cells and peritumoral deposition of matrix proteins were evaluated. The association between staining results and patient age, tumour stage, histological grade, and survival was studied. RESULTS: Positive cytoplasmic staining for laminin, fibronectin, and collagen IV was observed in 17 (23.9%), 27 (38%), and 10 (14.1%) cases, respectively. Staining for laminin was most pronounced in the invasive front of tumour islands, while for fibronectin and collagen IV it appeared to be diffuse. Peritumoral staining for laminin and collagen IV was detected in 12 cases (16.9%). Early stage (Ia1-Ia2) tumours were uniformly negative for all three proteins. Cytoplasmic staining for laminin correlated with positive staining for fibronectin and collagen IV, and with the presence of a peritumoral deposition of collagen IV and laminin. There was no correlation with any of the three markers between staining results and patient age, stage, grade, or survival. CONCLUSIONS: Expression of extracellular matrix proteins in some cervical squamous cell carcinomas might reflect the enhanced ability of these tumours to modify the peritumoral stroma. This ability seems to be absent in early stage tumours. The correlation between intracytoplasmic and peritumoral expression of matrix proteins supports the evidence of their synthesis by tumour cells. However, this property did not correlate with disease outcome in this study. (+info)Screening for cervical cancer: a review of women's attitudes, knowledge, and behaviour. (4/6661)
The United Kingdom (UK) cervical screening programme has been successful in securing participation of a high proportion of targeted women, and has seen a fall in mortality rates of those suffering from cervical cancer. There remains, however, a significant proportion of unscreened women and, of women in whom an abnormality is detected, many will not attend for colposcopy. The present work reviews the psychological consequences of receiving an abnormal cervical smear result and of secondary screening and treatment, and examines reasons for women's non-participation in the screening programme. Psychological theories of screening behavior are used to elucidate women's reactions and to suggest methods of increasing participation, of improving the quality of the service, and of reducing women's anxiety. A literature search identified studies that examine factors influencing women's participation in the screening programme, their psychological reaction to the receipt of an abnormal cervical smear result, and experiences of colposcopy. Reasons for non-participation include administrative failures, unavailability of a female screener, inconvenient clinic times, lack of awareness of the test's indications and benefits, considering oneself not to be at risk of developing cervical cancer, and fear of embarrassment, pain, or the detection of cancer. The receipt of an abnormal result and referral for colposcopy cause high levels of distress owing to limited understanding of the meaning of the smear test; many women believe the test aims to detect existing cervical cancer. The quality of the cervical screening service can be enhanced by the provision of additional information, by improved quality of communication, and by consideration of women's health beliefs. This may result in increased participation in, and satisfaction with, the service. (+info)Analysis of TSG101 tumour susceptibility gene transcripts in cervical and endometrial cancers. (5/6661)
Carcinoma of the uterine cervix is a common malignancy among women that has been found to show loss of heterozygosity in the chromosome 11p. Recent studies have localized the TSG101 gene in this region, and also demonstrated a high frequency of abnormalities of this gene in human breast cancer. To determine the role of the TSG101 gene in the carcinogenesis of cervical and uterine carcinoma, 19 cases of cervical carcinoma and five cases of endometrial carcinoma, as well as nearby non-cancerous tissue from the same patients, and 16 blood samples from healthy persons as normal control were analysed by Southern blot analysis of genomic DNA, reverse transcription of the TSG101 mRNA followed by PCR amplification and sequencing of the products. We found that abnormal transcripts of the TSG101 gene were common both in cancerous or non-cancerous tissues of the uterus and cervix and in normal peripheral mononuclear cells. There was no genomic deletion or rearrangement in spite of the presence of abnormal transcripts, and no definite relationship between the abnormal transcripts and HPV infection was found. Although the frequency of abnormal transcripts was higher in cancerous than in non-cancerous tissue, normal peripheral mononuclear cells also had abnormal transcripts. Given these findings, the role of the TSG101 gene as a tumour-suppressor gene should be re-evaluated. Because some aberrant transcripts could be found at the first PCR reaction, we suggest that the aberrant transcripts might be the result of imperfect minor splicesome products. (+info)A possible involvement of aberrant expression of the FHIT gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix. (6/6661)
To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (CINs)]. We also examined a link between the occurrence of the aberrant expression and human papillomavirus (HPV). We detected the aberrant FHIT transcripts in 11 of 25 (44%) cervical invasive squamous cell carcinomas and in 5 of 14 (36%) high-grade CINs (CIN 2 or 3), whereas they were not found in seven non-squamous type and four low-grade CINs (CIN 1). The alteration patterns of the FHIT gene expression in high-grade CINs were virtually similar to those found in invasive carcinomas, such that the exons 5-7 were consistently deleted associated or unassociated with loss of the exon 4 and/or 8. The incidence of the aberrant expression was not related to the presence of HPV and its type. These data indicate that the aberrant expression of the FHIT gene is observed in precursor lesions of cervical carcinoma as well as invasive carcinomas, with its incidence not increasing with advance of clinical stage. Given the squamous cell type dominant expression, the aberrant expression may play a critical role in the generation of squamous cell carcinoma of the uterine cervix, but not the consequence of the progression of the cancer. (+info)Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity. (7/6661)
Cervical carcinoma is an AIDS-defining illness. The expression of folate receptors (FRs) in cervical carcinoma (HeLa-IU1) cells was modulated by stable transduction of FR cDNA encapsidated in recombinant adeno-associated virus-2 in the sense and antisense orientation (sense and antisense cells, respectively). Although sense cells proliferated slower than antisense or untransduced cells in vivo and in vitro in 2% (but not 10%) FCS, [methyl-3H]thymidine incorporation into DNA was significantly increased in sense cells in 10% serum; therefore, the basis for this discrepancy was investigated. The activity of thymidine kinase (TK) was subsequently directly correlated with the extent of FR expression in single cell-derived clones of transduced cells. This elevated TK activity was not a result of recruitment of the salvage pathway based on the presence of adequate dTTP pools, normal thymidylate synthase (TS) activity, persistence of increased thymidine incorporation despite the exogenous provision of excess 5,10-methylene-tetrahydrofolate, and documentation of adequate folates in sense cells. The increase in TK activity conferred significant biological properties to sense cells (but not antisense or untransduced cells) as demonstrated by augmented phosphorylation of 3'-azido-3'-deoxythymidine (AZT) and concomitantly greater sensitivity to the cytotoxic effects of AZT. Conversely, sense cells were highly resistant to methotrexate, but this was reversed by the addition of AZT. The direct correlation of FR expression and TK activity indicates a previously unrecognized consequence of FR overexpression. (+info)Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women. (8/6661)
BACKGROUND: Human papillomavirus (HPV) infection is associated with precancerous cervical squamous intraepithelial lesions commonly seen among women infected with human immunodeficiency virus-1 (HIV). We characterized HPV infection in a large cohort of HIV-positive and HIV-negative women participating in the Women's Interagency HIV Study to determine the prevalence of and risk factors for cervicovaginal HPV infection in HIV-positive women. METHODS: HIV-positive (n = 1778) and HIV-negative (n = 500) women were tested at enrollment for the presence of HPV DNA in a cervicovaginal lavage specimen. Blood samples were tested for HIV antibody status, level of CD4-positive T cells, and HIV RNA load (copies/mL). An interview detailing risk factors was conducted. Univariate and multivariate analyses were performed. RESULTS: Compared with HIV-negative women, HIV-positive women with a CD4+ cell count of less than 200/mm3 were at the highest risk of HPV infection, regardless of HIV RNA load (odds ratio [OR] = 10.13; 95% confidence interval [CI] = 7.32-14.04), followed by women with a CD4+ count greater than 200/mm3 and an HIV RNA load greater than 20,000 copies/mL (OR = 5.78; 95% CI = 4.17-8.08) and women with a CD4+ count greater than 200/mm3 and an HIV RNA load less than 20,000 copies/mL (OR = 3.12; 95% CI = 2.36-4.12), after adjustment for other factors. Other risk factors among HIV-positive women included racial/ethnic background (African-American versus Caucasian, OR = 1.64; 95% CI = 1.19-2.28), current smoking (yes versus no; OR = 1.55; 95% CI = 1.20-1.99), and younger age (age < 30 years versus > or = 40 years; OR = 1.75; 95% CI = 1.23-2.49). CONCLUSIONS: Although the strongest risk factors of HPV infection among HIV-positive women were indicators of more advanced HIV-related disease, other factors commonly found in studies of HIV-negative women, including racial/ethnic background, current smoking, and age, were important in HIV-positive women as well. (+info)Uterine cervical neoplasms, also known as cervical cancer or cervical dysplasia, refer to abnormal growths or lesions on the lining of the cervix that have the potential to become cancerous. These growths are usually caused by human papillomavirus (HPV) infection and can be detected through routine Pap smears.
Cervical neoplasms are classified into different grades based on their level of severity, ranging from mild dysplasia (CIN I) to severe dysplasia or carcinoma in situ (CIN III). In some cases, cervical neoplasms may progress to invasive cancer if left untreated.
Risk factors for developing cervical neoplasms include early sexual activity, multiple sexual partners, smoking, and a weakened immune system. Regular Pap smears and HPV testing are recommended for early detection and prevention of cervical cancer.
Pancreatic neoplasms refer to abnormal growths in the pancreas that can be benign or malignant. The pancreas is a gland located behind the stomach that produces hormones and digestive enzymes. Pancreatic neoplasms can interfere with the normal functioning of the pancreas, leading to various health complications.
Benign pancreatic neoplasms are non-cancerous growths that do not spread to other parts of the body. They are usually removed through surgery to prevent any potential complications, such as blocking the bile duct or causing pain.
Malignant pancreatic neoplasms, also known as pancreatic cancer, are cancerous growths that can invade and destroy surrounding tissues and organs. They can also spread (metastasize) to other parts of the body, such as the liver, lungs, or bones. Pancreatic cancer is often aggressive and difficult to treat, with a poor prognosis.
There are several types of pancreatic neoplasms, including adenocarcinomas, neuroendocrine tumors, solid pseudopapillary neoplasms, and cystic neoplasms. The specific type of neoplasm is determined through various diagnostic tests, such as imaging studies, biopsies, and blood tests. Treatment options depend on the type, stage, and location of the neoplasm, as well as the patient's overall health and preferences.
Murine respirovirus
P16
Urogenital neoplasm
MORT (long non-coding RNA)
Florid cutaneous papillomatosis
Hematometra
Adolf Gusserow
Adenosarcoma
Cervical cancer
Dyskaryosis
List of MeSH codes (C13)
Glassy cell carcinoma of the cervix
List of cancer types
Mixed Müllerian tumor
Obstetrical bleeding
Carcinoma in situ
MAGEA4
List of MeSH codes (C04)
Polyp (medicine)
Small-cell carcinoma
List of skin conditions
Uterus
Brachytherapy
Fibroblast activation protein, alpha
Glossary of medicine
Ovarian cancer
Estrogen (medication)
Interventional radiology
Hysterectomy
Uterine fibroid
Uterine Cervical Neoplasms - Medical Dictionary online-medical-dictionary.org
Uterine Cervical Neoplasms | Profiles RNS
Results of search for 'su:{Uterine cervical neoplasms}' › WHO HQ Library catalog
Cervical Cancer | HPV | Human Papillomavirus | MedlinePlus
Cervical cancer and use of hormonal contraceptives: a systematic review
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Cervical Cancer Imaging: Practice Essentials, Computed Tomography (CT), Magnetic Resonance Imaging (MRI)
Cost-effectiveness of HPV vaccination in the context of high cervical cancer incidence and low screening coverage
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De novo establishment and cost-effectiveness of Papanicolaou cytology screening services in the Socialist Republic of Vietnam.
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DailyMed - CEVIMELINE HYDROCHLORIDE capsule
Prediction of lymphovascular space invasion in patients with endometrial cancer
Predicting cervical cancer1
- Beyond Sedlis-A novel histology-specific nomogram for predicting cervical cancer recurrence risk: An NRG/GOG ancillary analysis. (ouhsc.edu)
Carcinoma10
- A research for the relationship between human papillomavirus and human uterine cervical carcinoma. (nih.gov)
- Biopsies from 318 cases with squamous cell carcinoma of the uterine cervix, 48 with cervical and vulvar condylomata, 14 with cervical intraepithelial neoplasia (CIN), 34 with chronic cervicitis and 24 with normal cervical epithelium were collected from different geographic regions with different cervical cancer mortalities. (nih.gov)
- The DNA.DNA dot-blot and Southern blot hybridization results show that there is a close relationship between HPV-16 and the uterine cervical squamous cell carcinoma in China. (nih.gov)
- It is suggested that HPV-16 infection may be an etiological factor in the development of human cervical carcinoma. (nih.gov)
- CT of clinical stage IIB cervical carcinoma. (medscape.com)
- CT of a patient with stage IVB cervical carcinoma. (medscape.com)
- BACKGROUND: Cervical carcinoma is the leading cause of cancer-related death among women in the developing world. (duke.edu)
- Outcomes measured included life expectancy, cervical carcinoma incidence, cost per woman, and cost-effectiveness. (duke.edu)
- Assuming 70% program participation, cervical carcinoma incidence will decrease from 26 in 100,000 to 14.8 in 100,000, and cost-effectiveness will be $725 per discounted life-year. (duke.edu)
- Cytology-based screening methods for cervical adenocarcinoma (ADC) and to a lesser extent squamous-cell carcinoma (SCC) suffer from low sensitivity. (oncotarget.com)
Liver neoplasms1
- Percutaneous ethanol injection (PEI) for liver neoplasms when criteria above are not met. (aetna.com)
CERVIX3
- Cancer of the uterine cervix (cervical cancer) is largely a preventable disease that is characterized by a long lead time. (medscape.com)
- This image shows a hypoattenuating tumor occupying the entire cervix and extending to the outer posterior and right cervical margins. (medscape.com)
- Cancer of the cervix is preventable through vaccination against human papillomavirus and by screening and treatment of cervical precancers. (stanford.edu)
Human Papillomavirus6
- Human papillomavirus (HPV) is believed to be the most important cause of cervical cancer. (nih.gov)
- Introduction: The screening program for cervical cancer in Sweden recommends the use of primary human papillomavirus (HPV) screening for women aged ≥30 to 65 years. (lu.se)
- Cervical cancer is the most common malignancy among women particularly in developing countries, with human papillomavirus (HPV) 16 causing 50% of invasive cervical cancers. (elsevierpure.com)
- Current guidelines from the US Preventive Services Task Force and the American Cancer Society incorporate the use of cervical cytology and high-risk human papillomavirus tests performed every 3 to 5 years for screening in average-risk asymptomatic patients. (stanford.edu)
- Background: The ability for women to self-collect human papillomavirus (HPV) samples can potentially reduce the risk of cervical cancer and increase screening coverage. (bvsalud.org)
- To investigate the clinical role of nm23 expression in identifying both high‐risk human papillomavirus (HR‐HPV) and high‐grade cervical lesions or carcinomas [cervical intraepithelial neoplasia 2 + (CIN2 + )], and to compare it with p16 overexpression, as this latter biomarker has already been reported widely in HR‐HPV infected cervical lesions. (mcmaster.ca)
Neoplasia1
- The risk of cervical intra-epithelial neoplasia grade 2/3 (CIN2/3) in these women is low. (dundee.ac.uk)
Tumors2
- Tumors usually extend one to eight segments in the cervical region. (magiran.com)
- A white paper [PDF, 38 pages 2 MB] issued by the Program in September 2021 found that the available scientific evidence provided sufficient support to add uterine cancer to the List, but only for those Program members who already have certified WTC-related estrogen-secreting tumors. (cdc.gov)
Screening25
- Cervical Precancers and Cancers Attributed to HPV Types by Race and Ethnicity: Implications for Vaccination, Screening, and Management. (ouhsc.edu)
- Cervical screening : a practical guide / Ann McPherson. (who.int)
- Cervical cancer screening programmes : managerial guidelines. (who.int)
- Cytological screening in the control of cervical cancer : technical guidelines. (who.int)
- The results were broadly similar for invasive and in situ cervical cancers, for squamous cell and adenocarcinoma, and in studies that adjusted for HPV status, number of sexual partners, cervical screening, smoking, or use of barrier contraceptives. (nih.gov)
- [ 4 ] However, invasive cervical cancer remains a disease of significant morbidity, and it is a major cause of cancer deaths in women worldwide, although the incidence and mortality rates of invasive cervical cancer have declined substantially (particularly in countries that have well-developed screening programs). (medscape.com)
- Estonia has high cervical cancer incidence and low screening coverage. (fao.org)
- We modelled the impact of population-based bivalent, quadrivalent or nonavalent HPV vaccination alongside cervical cancer screening.A Markov cohort model of the natural history of HPV infection was used to assess the cost-effectiveness of vaccinating a cohort of 12-year-old girls with bivalent, quadrivalent or nonavalent vaccine in two doses in a national, school-based vaccination programme. (fao.org)
- The results were most sensitive to changes in discount rate, vaccination regimen, vaccine prices and cervical cancer screening coverage.Vaccination of 12-year-old girls alongside current cervical cancer screening can be considered a cost-effective intervention in Estonia. (fao.org)
- The absence of cervical screening in Vietnam and other developing countries is due in large part to the perceived expense of implementing Papanicolaou cytology screening services, although, to the authors' knowledge, the cost-effectiveness of establishing such services has never been studied in a developing country. (duke.edu)
- Cervical screening during the COVID-19 pandemic: optimising recovery strategies. (elsevierpure.com)
- We aim to inform the deliberations of decision makers in high-income settings regarding their cervical cancer screening policy response. (elsevierpure.com)
- These measures might exacerbate pre-existing inequalities in accessing cervical screening by disregarding the risk profile of the individuals attending. (elsevierpure.com)
- Modelling of cervical screening outcomes before and during the pandemic supports risk-based strategies as the most effective way for screening services to recover. (elsevierpure.com)
- Dive into the research topics of 'Cervical screening during the COVID-19 pandemic: optimising recovery strategies. (elsevierpure.com)
- Clinical implications of screening for cervical cancer under Medicare: The natural history of cervical cancer in the elderly: What do we know? (elsevierpure.com)
- Dive into the research topics of 'Clinical implications of screening for cervical cancer under Medicare: The natural history of cervical cancer in the elderly: What do we know? (elsevierpure.com)
- The following outlines evidence gaps for client reminders to increase breast, cervical, or colorectal cancer screening. (thecommunityguide.org)
- Cervical Cancer Screening: Evolution of National Guidelines and Current Recommendations. (stanford.edu)
- Cervical cancer screening has evolved since the Pap smear was first discovered in the 1920s. (stanford.edu)
- Objectives: To assess the willingness to HPV self-sampling for cervical cancer screening and its predictors among women attending outpatient clinics in Arusha region, northern Tanzania. (bvsalud.org)
- Conclusion: The majority of women were willing to self-collect HPV samples for cervical cancer screening. (bvsalud.org)
- Self-collection is, therefore, an acceptable and viable means of screening for cervical cancer, which has great implications for Tanzania from a health policy perspective. (bvsalud.org)
- Factors affecting cervical screening uptake in prisoners. (ox.ac.uk)
- SOX1 and SOX14 are methylation biomarkers applicable for screening of all cervical cancer types. (oncotarget.com)
Dysplasia1
- Cervical Dysplasia: Is It Cancer? (medlineplus.gov)
Cancers2
- Cancers associés aux virus en Afrique. (who.int)
- As many as 5% of cervical cancers may not be associated with HPV. (medscape.com)
Metastasis1
- Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
Melanoma2
- Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
- Cervical cancer is the second most frequent form of the disease among women, in Brazil, following non-melanoma skin cancer. (bvsalud.org)
Lesions2
- Whereas the HPV-16 DNA sequence was only present as an episome in normal cervical epithelium and cervical benign lesions. (nih.gov)
- Immunohistochemical evaluation of nm23 and p16 in 143 cervical biopsy specimens including negative, low‐ and high‐grade lesions and squamous carcinomas (SC). (mcmaster.ca)
Women with cervical cancer2
- 28 eligible studies were identified, together including 12531 women with cervical cancer. (nih.gov)
- The median number (range) of women with cervical cancer treated at each center annually was 32 (15-120). (diva-portal.org)
Complications1
- We provided a comprehensive analysis of rate, pattern, and severity of early and late postoperative complications in a very large, single-institution series of locally advanced cervical cancer (LACC) patients administered CT/RT plus radical surgery (RS). (unicatt.it)
Vaginal and anal1
- During fellowship she was trained in advanced colposcopy, high-resolution anoscopy (HRA) and treatment of cervical, vulvar, vaginal and anal disease. (stanford.edu)
Incidence3
- Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype. (ouhsc.edu)
- Cervical cancer is the third most common cancer in women worldwide, with high incidence in lowest income countries. (biomedcentral.com)
- Vaccination against Human Papilloma Virus (HPV) may help to reduce the incidence of cervical cancer. (biomedcentral.com)
Locally advanced cervical1
- The purpose of this study is to evaluate the efficacy and safety of pembrolizumab plus concurrent chemoradiotherapy compared to placebo plus concurrent chemoradiotherapy in participants with locally advanced cervical cancer. (msdoncologyclinicaltrials.com)
Carcinogenesis1
- This implies that E6 and E7 may be the oncogenic genes of HPV-16 and play an important role in the carcinogenesis of human cervical epithelial cells. (nih.gov)
Oncology1
- Association of Sialyl Tn antigen with cervical cancer lymph node status: An NRG oncology/GOG study. (ouhsc.edu)
Histologically2
- To estimate the added cost of using cytology to identify each histologically confirmed cervical HSIL case among Aptima HPV-negative women, we used the current cost of €21.2 per cytology evaluation at our laboratory. (lu.se)
- The neoplasms may be histologically the same or different, and may be found in the same or different sites. (lookformedical.com)
Cytology2
- OBJECTIVE: Worldwide, each year, large numbers of women are referred for colposcopy following low-grade abnormal cervical cytology. (dundee.ac.uk)
- Outcomes included percentages reporting significant anxiety (HADS anxiety subscale score ≥11), significant depression (HADS depression subscale score ≥8) or worries about the result of the next cytology test, cervical cancer, having sex, future fertility and general health at each time point (point prevalence) and during follow-up (cumulative prevalence). (dundee.ac.uk)
Risk Factors1
- 0.001), and presence of cervical stromal invasion (P = 0.002) were identified as the risk factors for LVSI. (medsci.org)
Women's Health1
- In addition, given the substantial morbidity and mortality associated with cervical cancer, effective strategies for its prevention and treatment are critical for improving women's health throughout the developing world [ 14 ]. (biomedcentral.com)
MeSH1
- Uterine Cervical Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
Tumor3
- Note: Program members who have a certified WTC-related estrogen-secreting tumor can already have their uterine cancer certified as a health condition medically associated with the certified WTC-related estrogen-secreting tumor, assuming all other certification requirements, such as latency and exposure duration, are met. (cdc.gov)
- Predict the presence of lymphovascular space invasion (LVSI), using uterine factors such as tumor diameter (TD), grade, and depth of myometrial invasion (MMI). (medsci.org)
- We defined the "LVSI index" as "TD×%MMI×tumor grade×cervical stromal involvement. (medsci.org)