Tumors or cancer of the UTERINE CERVIX.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A group of Indian Ocean Islands, east of Tanzania. Their capital is Victoria. They were first claimed by the French in 1744 but taken by the English in 1794 and made a dependency of MAURITIUS in 1810. They became a crown colony in 1903 and a republic within the Commonwealth in 1976. They were named for the French finance minister, Jean Moreau de Sechelles, but respelled by the English in 1794. (From Webster's New Geographical Dictionary, 1988, p1102 & Room, Brewer's Dictionary of Names, 1992, p496)
A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
All of Africa except Northern Africa (AFRICA, NORTHERN).
The geographical area of Africa comprising BURUNDI; DJIBOUTI; ETHIOPIA; KENYA; RWANDA; SOMALIA; SUDAN; TANZANIA; and UGANDA.
A specialized agency of the United Nations designed as a coordinating authority on international health work; its aim is to promote the attainment of the highest possible level of health by all peoples.
A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)
A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. They are coniferous evergreen trees with long, flat, spirally arranged needles that grow directly from the branch.
The examination, therapy or surgery of the cervix and vagina by means of a specially designed endoscope introduced vaginally.
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
The condition in which reasonable knowledge regarding risks, benefits, or the future is not available.
The concept covering the physical and mental conditions of women.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Tumors or cancer of the THYROID GLAND.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Division of tissues by a high-frequency current applied locally with a metal instrument or needle. (Stedman, 25th ed)
Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.
The excision of a cone of tissue, especially of the CERVIX UTERI.

Hybrid capture II, a new sensitive test for human papillomavirus detection. Comparison with hybrid capture I and PCR results in cervical lesions. (1/6661)

AIM: To test a new assay for the detection of human papillomavirus (HPV) DNA, hybrid capture II (HC II), compared with the previous commercialized hybrid capture I (HC I) and polymerase chain reaction (PCR) results on cervical scrapes from fresh cone excision biopsy samples. METHODS: The three methods were used on cervical scrapes from 42 fresh cone excision biopsy samples. There were nine metaplastic and inflammatory lesions, five low grade lesions, and 28 high grade lesions. PCR was performed using the general primers GP5+/GP6+. The viral load of high risk HPV DNA was estimated by the ratio of relative light units to positive control values in the samples. RESULTS: The sensitivity of HC I for the detection of high grade lesions was 71.4%, while it was 92.8% for HC II and 96.4% for the PCR. Considering only the absence of detectable cervical in situ neoplasia, the specificity was 88.9% for HC I, 66.7% for HC II, and 66.7% for PCR. With HC II, for a ratio of cervical sample to normal control of > 200, the sensitivity for the detection of high grade lesion was only 34.6% with a specificity of 66.7%. CONCLUSIONS: HPV detection with the HC II assay is more sensitive than the previous HC I and represents a more convenient and easier test than PCR for routine use. Nevertheless the viral load estimated with this test cannot be a reliable predictive indicator of high grade lesions.  (+info)

Immunohistochemical expression of mdm2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. (2/6661)

AIM: To investigate the immunocytochemical staining pattern of mdm2 and p21WAF1 proteins in invasive cervical cancer and to determine its relation with the expression of p53 and with the high risk HPV infection. METHODS: Immunocytochemistry for p53, mdm2, and p21WAF1 was performed in 31 paraffin embedded sections of invasive cervical cancer. The results were assessed by image analysis, evaluating for each protein the optical density of the immunostained area, scored as percentage of the total nuclear area. The presence of high risk human papillomavirus (HPV) infection was detected by using the polymerase chain reaction. RESULTS: Immunostaining for both mdm2 and p21WAF1 was correlated with p53 expression; however, the correlation between p53 and mdm2 (R = 0.49; p < 0.01) was more significant than between p53 and p21WAF1 (R = 0.31; p < 0.05); the less stringent correlation between p53 and p21WAF1 might reflect the p53 independent mechanisms of p21WAF1 induction. Similar average levels of p53, mdm2, and p21WAF1 immunostaining were found in the presence or absence of high risk HPV-DNA, without significant differences between the two groups. CONCLUSIONS: These data suggest that mdm2 and p21WAF1 proteins are expressed in invasive cervical cancer and that their immunocytochemical staining pattern is not abrogated by the presence of high risk HPV genomic sequences.  (+info)

Expression of extracellular matrix proteins in cervical squamous cell carcinoma--a clinicopathological study. (3/6661)

AIM: To evaluate the intracellular and peritumoral expression of matrix proteins in squamous cell carcinoma of the uterine cervix using immunohistochemistry. METHODS: 71 squamous cell carcinomas and 10 controls were stained for laminin, fibronectin, and collagen IV. Cytoplasmic staining in tumour cells and peritumoral deposition of matrix proteins were evaluated. The association between staining results and patient age, tumour stage, histological grade, and survival was studied. RESULTS: Positive cytoplasmic staining for laminin, fibronectin, and collagen IV was observed in 17 (23.9%), 27 (38%), and 10 (14.1%) cases, respectively. Staining for laminin was most pronounced in the invasive front of tumour islands, while for fibronectin and collagen IV it appeared to be diffuse. Peritumoral staining for laminin and collagen IV was detected in 12 cases (16.9%). Early stage (Ia1-Ia2) tumours were uniformly negative for all three proteins. Cytoplasmic staining for laminin correlated with positive staining for fibronectin and collagen IV, and with the presence of a peritumoral deposition of collagen IV and laminin. There was no correlation with any of the three markers between staining results and patient age, stage, grade, or survival. CONCLUSIONS: Expression of extracellular matrix proteins in some cervical squamous cell carcinomas might reflect the enhanced ability of these tumours to modify the peritumoral stroma. This ability seems to be absent in early stage tumours. The correlation between intracytoplasmic and peritumoral expression of matrix proteins supports the evidence of their synthesis by tumour cells. However, this property did not correlate with disease outcome in this study.  (+info)

Screening for cervical cancer: a review of women's attitudes, knowledge, and behaviour. (4/6661)

The United Kingdom (UK) cervical screening programme has been successful in securing participation of a high proportion of targeted women, and has seen a fall in mortality rates of those suffering from cervical cancer. There remains, however, a significant proportion of unscreened women and, of women in whom an abnormality is detected, many will not attend for colposcopy. The present work reviews the psychological consequences of receiving an abnormal cervical smear result and of secondary screening and treatment, and examines reasons for women's non-participation in the screening programme. Psychological theories of screening behavior are used to elucidate women's reactions and to suggest methods of increasing participation, of improving the quality of the service, and of reducing women's anxiety. A literature search identified studies that examine factors influencing women's participation in the screening programme, their psychological reaction to the receipt of an abnormal cervical smear result, and experiences of colposcopy. Reasons for non-participation include administrative failures, unavailability of a female screener, inconvenient clinic times, lack of awareness of the test's indications and benefits, considering oneself not to be at risk of developing cervical cancer, and fear of embarrassment, pain, or the detection of cancer. The receipt of an abnormal result and referral for colposcopy cause high levels of distress owing to limited understanding of the meaning of the smear test; many women believe the test aims to detect existing cervical cancer. The quality of the cervical screening service can be enhanced by the provision of additional information, by improved quality of communication, and by consideration of women's health beliefs. This may result in increased participation in, and satisfaction with, the service.  (+info)

Analysis of TSG101 tumour susceptibility gene transcripts in cervical and endometrial cancers. (5/6661)

Carcinoma of the uterine cervix is a common malignancy among women that has been found to show loss of heterozygosity in the chromosome 11p. Recent studies have localized the TSG101 gene in this region, and also demonstrated a high frequency of abnormalities of this gene in human breast cancer. To determine the role of the TSG101 gene in the carcinogenesis of cervical and uterine carcinoma, 19 cases of cervical carcinoma and five cases of endometrial carcinoma, as well as nearby non-cancerous tissue from the same patients, and 16 blood samples from healthy persons as normal control were analysed by Southern blot analysis of genomic DNA, reverse transcription of the TSG101 mRNA followed by PCR amplification and sequencing of the products. We found that abnormal transcripts of the TSG101 gene were common both in cancerous or non-cancerous tissues of the uterus and cervix and in normal peripheral mononuclear cells. There was no genomic deletion or rearrangement in spite of the presence of abnormal transcripts, and no definite relationship between the abnormal transcripts and HPV infection was found. Although the frequency of abnormal transcripts was higher in cancerous than in non-cancerous tissue, normal peripheral mononuclear cells also had abnormal transcripts. Given these findings, the role of the TSG101 gene as a tumour-suppressor gene should be re-evaluated. Because some aberrant transcripts could be found at the first PCR reaction, we suggest that the aberrant transcripts might be the result of imperfect minor splicesome products.  (+info)

A possible involvement of aberrant expression of the FHIT gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix. (6/6661)

To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (CINs)]. We also examined a link between the occurrence of the aberrant expression and human papillomavirus (HPV). We detected the aberrant FHIT transcripts in 11 of 25 (44%) cervical invasive squamous cell carcinomas and in 5 of 14 (36%) high-grade CINs (CIN 2 or 3), whereas they were not found in seven non-squamous type and four low-grade CINs (CIN 1). The alteration patterns of the FHIT gene expression in high-grade CINs were virtually similar to those found in invasive carcinomas, such that the exons 5-7 were consistently deleted associated or unassociated with loss of the exon 4 and/or 8. The incidence of the aberrant expression was not related to the presence of HPV and its type. These data indicate that the aberrant expression of the FHIT gene is observed in precursor lesions of cervical carcinoma as well as invasive carcinomas, with its incidence not increasing with advance of clinical stage. Given the squamous cell type dominant expression, the aberrant expression may play a critical role in the generation of squamous cell carcinoma of the uterine cervix, but not the consequence of the progression of the cancer.  (+info)

Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity. (7/6661)

Cervical carcinoma is an AIDS-defining illness. The expression of folate receptors (FRs) in cervical carcinoma (HeLa-IU1) cells was modulated by stable transduction of FR cDNA encapsidated in recombinant adeno-associated virus-2 in the sense and antisense orientation (sense and antisense cells, respectively). Although sense cells proliferated slower than antisense or untransduced cells in vivo and in vitro in 2% (but not 10%) FCS, [methyl-3H]thymidine incorporation into DNA was significantly increased in sense cells in 10% serum; therefore, the basis for this discrepancy was investigated. The activity of thymidine kinase (TK) was subsequently directly correlated with the extent of FR expression in single cell-derived clones of transduced cells. This elevated TK activity was not a result of recruitment of the salvage pathway based on the presence of adequate dTTP pools, normal thymidylate synthase (TS) activity, persistence of increased thymidine incorporation despite the exogenous provision of excess 5,10-methylene-tetrahydrofolate, and documentation of adequate folates in sense cells. The increase in TK activity conferred significant biological properties to sense cells (but not antisense or untransduced cells) as demonstrated by augmented phosphorylation of 3'-azido-3'-deoxythymidine (AZT) and concomitantly greater sensitivity to the cytotoxic effects of AZT. Conversely, sense cells were highly resistant to methotrexate, but this was reversed by the addition of AZT. The direct correlation of FR expression and TK activity indicates a previously unrecognized consequence of FR overexpression.  (+info)

Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women. (8/6661)

BACKGROUND: Human papillomavirus (HPV) infection is associated with precancerous cervical squamous intraepithelial lesions commonly seen among women infected with human immunodeficiency virus-1 (HIV). We characterized HPV infection in a large cohort of HIV-positive and HIV-negative women participating in the Women's Interagency HIV Study to determine the prevalence of and risk factors for cervicovaginal HPV infection in HIV-positive women. METHODS: HIV-positive (n = 1778) and HIV-negative (n = 500) women were tested at enrollment for the presence of HPV DNA in a cervicovaginal lavage specimen. Blood samples were tested for HIV antibody status, level of CD4-positive T cells, and HIV RNA load (copies/mL). An interview detailing risk factors was conducted. Univariate and multivariate analyses were performed. RESULTS: Compared with HIV-negative women, HIV-positive women with a CD4+ cell count of less than 200/mm3 were at the highest risk of HPV infection, regardless of HIV RNA load (odds ratio [OR] = 10.13; 95% confidence interval [CI] = 7.32-14.04), followed by women with a CD4+ count greater than 200/mm3 and an HIV RNA load greater than 20,000 copies/mL (OR = 5.78; 95% CI = 4.17-8.08) and women with a CD4+ count greater than 200/mm3 and an HIV RNA load less than 20,000 copies/mL (OR = 3.12; 95% CI = 2.36-4.12), after adjustment for other factors. Other risk factors among HIV-positive women included racial/ethnic background (African-American versus Caucasian, OR = 1.64; 95% CI = 1.19-2.28), current smoking (yes versus no; OR = 1.55; 95% CI = 1.20-1.99), and younger age (age < 30 years versus > or = 40 years; OR = 1.75; 95% CI = 1.23-2.49). CONCLUSIONS: Although the strongest risk factors of HPV infection among HIV-positive women were indicators of more advanced HIV-related disease, other factors commonly found in studies of HIV-negative women, including racial/ethnic background, current smoking, and age, were important in HIV-positive women as well.  (+info)

In this meta-analysis which included data gathered from 22 case-control studies, involving a total of 10,073 subjects, which investigated an association between vitamin or antioxidant intake (or serum level) and cervical neoplasm risk, results found that intakes of vitamin B12 (OR=0.35), vitamin C (OR=0.67), vitamin E (OR=0.56), and beta-carotene (OR=0.68) were found to be associated with a significantly reduced odds ratio of cervical neoplasm. The authors state, The findings of this meta-analysis indicate that overall, there were preventive effects of vitamin or antioxidant intake on cervical neoplasms in case-control studies.. Click Here to visit the journal website. Subscription required to view the full text of the article.. ...
Since FTO was recognized as the first m6A demethylase, the understanding of its biological function has been widely expanded. However, the role of FTO in cervical cancer tumorigenesis remains unclear. In this study, we first analyzed the expression of FTO in two independent human cancer datasets and evaluated the correlation between FTO level and cervical cancer progression. Using small hairpin RNA technology, we explored the function of FTO in cervical cancer cell line Hela and SiHa cells, respectively. We then determined the FTO targets by performing transcriptional profile with FTO deficient and competent Hela cells, and finally validated these targets with ribosome profiling and functional rescue experiments. Our data suggested that FTO was frequently overexpressed in human cervical cancer tissues and highly correlated with cervical cancer progression. FTO serves as an oncogenic regulator for cervical cancer cells proliferation and migration which is vastly depended on its demethylase activity.
A previous study showed E-cadherin expression was lost in some cervical cancer cell lines and tumours. This study was designed to clarify the significance of DNA methylation in silencing E-cadherin expression. We examined promoter methylation of E-cadherin in five cervical cancer cell lines and 20 cervical cancer tissues using methylation-specific PCR (MSP) and bisulphite DNA sequencing. The correlation of E-cadherin methylation and expression together with methyltransferase (DNMT1) were further studied. We found that hypermethylation of E-cadherin was involved in five cervical cancer cell lines and 40% (8/20) of cervical cancer tissues. E-cadherin protein was lost in 6/8 (75%) samples and 3/5 (60%) cell lines with promoter methylation. E-cadherin methylation was significantly correlated with increased DNMT1. Using an antisense DNMT1 oligo to transfect into SiHa HeLa C33A cell line, E-cadherin protein was re-expressed. We concluded that loss of E-cadherin expression was in part correlated with ...
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Analysis of primary cervical cancer tissue of patients with pelvic lymph node metastasis. Positive lymph nodes are an important prognostic factor in early-stage cervical cancer patients. Results provide insight into the molecular basis of pelvic lymph node metastasis in early cervical cancer ...
This publication, Comprehensive cervical cancer control: a guide to essential practice (C4GEP), gives a broad vision of what a comprehensive approach to cervical cancer prevention and control means. In particular, it outlines the complementary strategies for comprehensive cervical cancer prevention and control, and highlights the need for collaboration across programmes, organizations and partners. This new guide updates the 2006 edition and includes the recent promising developments in technologies and strategies that can address the gaps between the needs for and availability of services for cervical cancer prevention and control. ...
Our study aimed to provide health economic data to inform the development of the Hungarian cervical cancer prevention program. First, the national program needs to address the problem of the inefficiency of the current screening program [5, 6]. We have previously developed a health economic model to support this decision making process [7]. Furthermore, with the introduction of vaccination against cervical cancer, a new policy question was raised: whether to include the vaccination of adolescent girls in the cervical cancer prevention program. We aimed to analyze this question from a health economic perspective.. Our modeling results predicted that adding vaccination of adolescent girls with the AS04-adjuvanted human papillomavirus 16/18 vaccine to the national cervical cancer screening program would be cost-effective in Hungary. Although our results were quite robust to the uncertainty in the input parameters, larger changes in the most influential parameters could considerably change the ...
TY - JOUR. T1 - Expression of Fas Ligand is Higher in Early Stage Cervical Cancer with Lymph Nodes Metastasis. AU - Irwanto, Yahya. AU - Purwoto, Gatot. AU - Sutrisna, Bambang. AU - Rustamadji, Primariadewi. PY - 2012/10. Y1 - 2012/10. N2 - Objective: To know whether the expression of Fas Ligand has correlation with incidene of metastasis of pelvic lymph node and lymph-vascular stromal invasion (LVSI). Methods: All patients diagnosed of cervical cancer stage IB or IIA who underwent radical hysterectomy in Dr. Cipto Mangunkusumo Central General Hospital from January 2008 until December 2009 were included in analytic cross sectional study. We tested expression of Fas Ligand in cervical cancer specimen by immunohystochemistry with monoclonal antibody. The expression of Fas Ligand was compared between the group of patients with a positive and negative pelvic lymph node and between LVSI positive and negative. The difference of expression in both group were statistically analized with Chi-square test ...
Julian Schink, MD, Chief, CTCA Division of Gynecologic Oncology, discusses recent findings that shed light on early-stage cervical cancer treatments in this Insider article.
Cervical cancer is a malignant tumor of the cervix, a part of the female reproductive tract. Recent studies have found the human papillomavirus (HPV) vaccine to be efficient in preventing high-grade cervical lesions. However, the exact effects and efficacy of the vaccine are not known. This study aims to evaluate the association between quadrivalent HPV vaccination and the risk of invasive cervical cancer.. This study included an open population of 1,672,983 girls and women aged 10-30 years. The researchers evaluated the association between HPV vaccination and the risk of invasive cervical cancer, keeping factors like follow-up and parental characteristics in check. The primary outcome of the study was the subsequent risk of invasive cervical cancer after HPV vaccination.. The included participants were evaluated for cervical cancer until they turned 31. The findings suggested that cervical cancer was reported in 19 women who had undergone quadrivalent HPV vaccination. In comparison, 438 women ...
Data & statistics on Cervical Cancer: Incidence of CIN 2/3 Detected Through Screening and Cervical Cancer Incidence Prior to Screening Incidence of CIN 2/3 Detected Through Screening and Cervical Cancer Incidence Prior to Screening. Rates are per 100,000 women undergoing routine cytologic screening for CIN 2/3, and per 100,000 women for cervical cancer. The peak incidence of invasive cervical cancer is observed approximately 25-30 years ..., Executive Summary Acronyms and Abbreviations Introduction 1.1 Background and purpose of this study 1.2 Methodology 1.3 Limitations of the study 1.4 Structure of the report Background 2.1 What is cervical cancer? 2.1.1 Risk factors and causes of cervical cancer 2.1.2 Development of cervical cancer 2.2 Prevention 2.2.1 Primary prevention 2.2.2 Secondary prevention 2.3 Diagnosis 2.3.1 Colposcopy 2.3.2 ..., Health burden of detected cervical intraepithelial neoplasia (CIN) 2 and 3, cervical cancer incidence, and mortality, before prophylactic vaccination and after
Data & statistics on Estimated Age-specific Cervical Cancer Mortality Rates in the Americas: Estimated Age-specific Cervical Cancer Mortality Rates in the Americas, 2000*, Calibration results of age-specific incidence and mortality of cervical cancer. The circles and bars represent the observed cancer incidence and mortality from the National Cancer Registry of Taiwan, respectively. The squares and hollow bars represent the predicted cancer incidence and mortality by the Markov model in which the current practice of cervical screening was applied from 30 years of age ..., Estimated age-specific cervical cancer death rate in an unscreened population (per 100,000)...
By Hui Xie-Zukauskas. While cervical cancer is one of the most common cancers in women, it is, thankfully, preventable. But do you know how to prevent cervical cancer? As the saying goes, what you dont know can hurt you. Here are five important approaches to cervical cancer prevention:. 1. Enhance awareness of cervical cancer.. Misconceptions and poor awareness about cervical cancer are common. Poor awareness may result in delayed detection and treatment due to lack of knowledge and motivation, which can promote poor survivorship. During cervical cancer awareness month, find a way to raise your awareness; e.g., read more information or watch videos on cervical cancer (at the CDC website), send this e-Card to loved ones or friends, and/or participate in a public service to spread the word.. 2. Vaccinate girls and boys.. More than 95 % of cervical cancer cases are closely associated with human papillomavirus (HPV) infection. Some types of HPV are also known to cause cancers of the anus, penis, ...
OBJECTIVE The purpose of the study was to investigate benign and malignant squamous cervical cells obtained by cervical swabs with regard to differentially expressed genes and gene expression profiling, in order to evaluate the biological behavior and clinical outcome of cervical malignancies. METHODS Cervical squamous cells from six women with high-risk human papillomavirus positive [HR-HPV(+)] cervical carcinoma and from six HPV-negative women with normal ectocervical cells were analyzed by cDNA array. RESULTS cDNA over-expression of several genes such as MET (c-met), Nm23-H1 (NME1), EGFR, KGFR, Nm23-H2 (NME2), ERBB2 (c-erbB-2), cyclin-dependent kinase inhibitor 4 (CDKN2A, p16INK4A), cytokeratin 8 (KRT8), KRAS (K-ras), FLT1, KGF (FGF7), BCL2-like 2 protein (BCL2L2), ERBB4, MYCN (N-myc), cyclin D1 (CCND1), KIT (c-kit), secreted phosphoprotein 1 (SPP1) and STAT1, was significant in cervical squamous cell carcinoma (CSCC). Gene expression was downregulated for 13 genes in CSCC, such as interleukin 1
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Objectives. Infection with high-risk human papillomavirus (HPV) is a critical factor associated withcarcinogenesis of the uterine cervix. HPV-16 is most frequently found, and is further subclassified into intratypicvariants based on the nucleotide sequences of the viral genes. Although certain HPV-16 variants are reported tobe associated with the progression of cervical lesions, these relationships remain controversial with differentresults for different populations. To provide data for another population, we investigated the prevalence ofHPV-16 and distributions of its intratypic variants among Mongolian women with cervical intraepithelialneoplasia (CIN) and invasive cervical cancer. Materials and Methods. We analyzed samples from 374 randomlyselected women who attended the National Cancer Center of Mongolia between January 2002 and July 2007,including 147 invasive cervical cancer patients, 127 CIN patients and 100 age-matched controls who werecytologically normal. HPV genotyping was initially
Previous studies have described the importance of DNA methylation in human cancers. Recently, an aberrant methylation pattern was found during the multistage pathogenesis of cervical cancer with an increasing trend to methylation with increasing pathological changes (7) . Promoter hypermethylation of various genes is a frequent epigenetic event in cervical carcinoma (6 , 7 , 15) .3 Epigenetic alterations have been successfully used as indicators of neoplastic serum DNA in patients with various carcinomas (16) . To date, no studies have been undertaken to investigate the methylation status of various genes in serum samples of cervical cancer patients. Recently, we identified five genes, namely CALCA, hTERT, MYOD1, PGR, and TIMP3, as being methylated significantly more frequently in cervical cancer tissue than in normal cervical tissue.3 In our study, all of the patients with methylated serum DNA revealed the same methylation pattern in the corresponding cervical cancer tissue, except one patient ...
article{9e26cd77-e33a-4061-b74b-6dd6a644862d, abstract = {BACKGROUND: Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clinical trials. Because the vast majority of women with positive cytology are also HPV DNA positive, screening strategies that use HPV DNA testing as the primary screening test may be more effective. METHODS: We used the database from the intervention arm (n = 6,257 women) of a population-based randomized trial of double screening with cytology and HPV DNA testing to evaluate the efficacy of 11 possible cervical screening strategies that are based on HPV DNA testing alone, cytology alone, and HPV DNA testing combined with cytology among women aged 32-38 years. The main outcome measures were sensitivity for detection of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) within 6 months of enrollment or at colposcopy for women with a ...
Cervix cancer does not spread early. It spreads by way of the lymphatic system. Cervix cancer screening should be offered to all women over 25 years. There is limited evidence of benefit from screening in women aged over 60 years, though the likely yield of screening is low in women over age 60 since the incidence of high-grade cervical lesions declines after middle age. Cervix cancer is preceded by cervical intraepithelial neoplasia (CIN). Surgery for CIN is effective at reducing the risk of subsequent invasive carcinoma.
MONDAY, Feb. 3, 2020 (HealthDay News) -- Vaccination and screening could nearly wipe out cervical cancer in North America in the next 20 years and rid the world of the disease within the next century, researchers say.. In a new study, the researchers assessed the potential impacts of the World Health Organizations (WHO) draft strategy for cervical cancer elimination, which calls for 90% of girls to be vaccinated against human papillomavirus (HPV) by 2030.. HPV causes most cervical cancer cases.. The WHO plan also calls for 70% of women to be screened for cervical cancer once or twice in their lifetime, and for 90% of women with precancerous lesions or cervical cancer to receive appropriate treatment.. With HPV vaccination alone, cervical cancer cases would fall 89% within a century in 78 countries hardest-hit by the disease. Thats 60 million cases of cervical cancer prevented, according to the report.. With the added tests and treatment of precancerous lesions, cervical cancer cases would fall ...
BACKGROUND Lymphatic and hematologic metastases are rare in microinvasive cervical cancers (FIGO stage IA1), supporting a role for conservative treatment. Cervical conization followed by prolonged surveillance is an accepted treatment in patients with low-risk features and negative surgical margins. This option is particularly appealing for younger or nulliparous patients, in whom fertility may be highly desired. CASE We report a case of a 22-year-old, HIV-negative female with stage IA1 squamous cell cervical carcinoma who was found to have bilateral lymph node metastases in both pelvic and para-aortic distributions after electing to undergo hysterectomy. CONCLUSION Clinicians treating patients with microinvasive cervical cancer conservatively must be aware of the possibility of lymph node involvement and should consider radiological imaging to look for metastatic disease.
TY - JOUR. T1 - Issues in cervical cancer incidence and treatment in HIV. AU - Einstein, Mark H.. AU - Phaeton, Rebecca. PY - 2010/9/1. Y1 - 2010/9/1. N2 - Purpose of review: Cervical disease burden continues to be especially high in HIV-infected women, even in the era of effective antiretroviral medications. This review discusses the multiple issues surrounding HIV-associated cervical cancer. Also, the unique treatment-related issues in HIV-associated cervical cancer are addressed. Recent findings: The incidence of invasive cervical cancer has remained stable in industrialized nations; however, it is only estimated in developing countries secondary to a relative lack of data collection and registries. Trends in HIV-associated cervical cancer have changed in the highly active antiretroviral therapy (HAART) era. Recent molecular pathways suggest that the natural progression of human papillomavirus infection, the causal agent in all cervical cancers, may be related to immune system dysfunction as ...
Question - my mom having 4th stage cervix carcinoma, suffering from diabetics, please help. Ask a Doctor about diagnosis, treatment and medication for Cervical cancer, Ask an Oncologist
According to the statistics for 2018, cervical cancer is the fourth most common cancer in women worldwide, with 569,847 patients yearly [1]. Patients with cervical cancer who have progressed to an inoperable stage or have experienced recurrence receive widely used anti-cancer chemotherapy and platinum-based chemotherapy [2]. Cisplatin is a platinum-based chemotherapeutic agent that is widely used for the treatment of malignant tumors, such as cervical cancer, lung cancer, and ovarian cancer [3]. Cisplatin mainly induces cross-linking at the N7-position of guanosine, which modifies DNA to induce apoptosis and kill cancer cells [4]. However, the use of cisplatin as a cancer treatment has been limited owing to its serious side effects involving the kidney or hearing impairment and the emergence of resistant cancer cells [5]. In order to overcome anti-cancer drug resistance, high-dose chemotherapy with increasing dose combination therapy that combines several chemotherapy agents, and concurrent ...
Worldwide, cervical cancer is the third most common type of cancer in women. It is much less common in the United States because of the routine use of Pap smears.. Cervical cancer starts in the cells on the surface of the cervix. There are two types of cells on the surface of the cervix, squamous and columnar. Most cervical cancers are from squamous cells.. Cervical cancer usually develops slowly. It starts as a precancerous condition called dysplasia. This condition can be detected by a Pap smear and is nearly 100% treatable. It can take years for dysplasia to develop into cervical cancer. Most women who are diagnosed with cervical cancer today have not had regular Pap smears, or they have not followed up on abnormal Pap smear results.. Almost all cervical cancers are caused by human papillomavirus (HPV). HPV is a common virus that is spread through skin-to-skin contact and also by sexual intercourse. There are many different types (strains) of HPV. Some strains lead to cervical cancer. Other ...
Conclusions: Magnetic resonance imaging stage IIB cervical cancers with negative PMI on physical examination should be surgically treated because of better survival rate than FIGO stage IIB cervical … Making an educated treatment decision begins with the stage, or progression, of the disease. In New Zealand, about 160 women develop cervical cancer each year - and about 50 die from it. If the biopsy shows abnormal cells on the surface of the cervix, you may need to have a cone biopsy or loop excision. In early, localized cervical cancer, five-year survival is 92 percent (SEER). Were trying to find your location, please click Allow if your browser is asking for your Objective: To investigate ethnic, socioeconomic, and urban/rural differences in stage at diagnosis and cervical cancer survival in New Zealand. Regular cervical screening is your best protection against developing cervical cancer. When you have either type of hysterectomy, you will also have a: Pelvic lymphadenectomy - removal of ...
References. 1. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189:12-9. [ Links ] 2. Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev. 2003;16:1-17. [ Links ] 3. Kuglik P, Kasikova K, Smetana J, Vallova V, Lastuvkova A, Moukova L, et al. Molecular cytogenetic analyses of hTERC (3q26) and MYC (8q24) genes amplifications in correlation with oncogenic human papilloma-virus infection in Czech patients with cervical intraepithelial neoplasia and cervical carcinomas. Neoplasma. 2015;62:130-9. [ Links ] 4. Sharma S, Mandal P, Sadhukhan T, Chowdhury RR, Mondal NR, Chakravarty B, et al. Bridging links between long noncoding RNA HOTAIR and HPV oncoprotein E7 in cervical cancer pathogenesis. Scientific Rep. 2015;5:11724. [ Links ] 5. Hu X-Y, Hou P-F, Li T-T, Quan H-Y, Li M-L, Lin T, et al. The roles of Wnt/β-catenin signaling pathway related lncRNAs in cancer. Int ...
Rab GTPases function as modulators in intracellular transport. Rab5a, a member of the Rab subfamily of small GTPases, is an important regulator of vesicle traffic from the plasma membrane to early endosomes. Recent findings have reported that Rab5a gene was involved in the progression of cancer. In the present study, we investigated the effect of Rab5a on cervical cancer invasion and metastasis and the molecular mechanism underlying the involvement of Rab5a. Rab5a expression was assessed by immunohistochemical analysis on a cervical cancer tissue microarray. RNA interference (RNAi) was performed to knock down the endogenous expression of Rab5a gene in HeLa and SiHa cells. Cell motility was evaluated using invasion assay and wound migration assay in vitro. The expression levels of integrin-associated molecules were detected by Western blot and immunofluorescence. We found that Rab5a was expressed at a high level in cervical cancer tissues. Silencing of Rab5a expression significantly decreased cancer cell
After the discovery of the role human papilloma virus (HPV) plays in cervical cancer development we have witnessed a change in the conception and interpretation of cervical cancer prevention processes. Primary prevention gained a new tool in the form of HPV vaccines. Secondary prevention, which is cervical intraepithelial neoplasia (CIN) detection, acquired a new diagnostic method - HPV test. Studies were initiated in order to determine the usefulness of HPV tests in cervical cancer prevention and screening. They revealed that DNA HPV test used in screening has higher sensitivity in CIN detection than PAP smear and that HPV negative patients are better and longer protected against developing cervical cancer in comparison to women with normal PAP smear results. HPV tests also possess a predictive value, which detects women more susceptible to developing cervical cancer in the future. PAP smear does not have a predictive value; it only detects a presence or absence of neoplasia at this particular ...
CIN2/3 have been increased for many years and mainly concern women aged 25-29 years. They are subsequent to a persistent HPV infection and are classically treated by conization. Recurrences occur in 7 to 18 % of cases, mainly after CIN3 management during the first 2 years of follow-up. Follow-up is crucial to detect and treat recurrence and to select high risk women who might develop cervical cancer. Colposcopy and cytology have been recommended since 1989 by French ANAES, but these methods have poor sensitivity and specificity. However, DNA HPV testing is more sensitive and has demonstrated a very high negative predictive value, while specificity and positive predictive value remain average. Other HPV markers like genotyping, viral load and integration begin to be used in screening but have not been investigated in CIN2/3 follow-up to assess the values of various HPV markers which predict CIN2/3 recurrence after conization. The primary objective is to describe HPV expression (genotyping, viral ...
A non profit organization initially led by the Cervical Cancer Prevention Network (CECAP) for the Cancer Institute Foundation (CIF), Bravehearts is dedicated to raising awareness on cervical cancer prevention. Bravehearts is currently supported by a growing number of women, including prominent personalities such as Abbygale Arenas-de Leon, who is the current president of the organization, Senator Loren Legarda, Pia Magalona, Ellen Tordesillas, Tessa Prieto-Valdes, Jeena Lopez, Maimai Davao, Joyette Jopson and Suzi Entrata.. The organization has held successful seminars and projects with the help of its partner organizations and companies. One of its more prominent events is the biking event, The Tour of Hope (TTOH). The tour was introduced in the Philippines in 2008 through the collaboration of GlaxoSmithKline Philippines and the UP Cancer Institute Foundations Cervical Cancer Prevention (CECAP) network program in strategic partnership with Team Davids Salon, the first all woman sports team in ...
The abnormal readings that predict cervical cancer are called cervical dysplasia, meaning that the cells of the cervix have been altered by the presence of HPV. These readings can be either LGSIL (low-grade squamous intraepithelial lesions) or HGSIL (high-grade squamous intraepithelial lesions). The higher the grade, the more abnormal the cells, and the closer to cancer it is. However, these LGSIL and HGSIL do not mean that cancer is present, only that abnormalities are present that may lead to cancer. When a pap test shows LGSIL or HGSIL, this means that HPV is definitely present, so there is no need to do a specific HPV test. (More on abnormal Pap testing in a later blog post ...
Treatment of cervical cancer has special steps not like any cancer nowadays, as its first and most important step is cervical cancer prevention , and then treatment of non- invasive cervical cancer which is called CIN treatment , and finally invasive cervical cancer treatment.. Follow up of these cases is not less important than treatment itself.. Cervical cancer prevention. There are multiple ways to prevent cervical cancer , the most important steps are screening by pap smear in all sexually active women and follow up that screening according to the new guide lines N.B : details n cervical cancer screening , also early detection and treatment of cervical infection with follow up of it can prevent cervical cancer , having protected sexual course also minimize the rate for sexual transmitted disease and so decrease risk for human papilloma virus infection , which is the main cause lead to cancer cervix .. Treatment of CIN( cervical intraepithial neoplasia , pre invasive cancer ...
Cervical cancer, with an annually increasing incidence rate, is becoming the leading cause of death among women in China. However, studies have shown that the early detection and accurate diagnosis of cervical cancer contribute to the long survival of cervical cancer patients. The machine learning method is a good substitute for manual diagnosis in the analysis of Pap smear cervical cell images, reflecting its effective and accurate classification. In the present study, a framework for cervical cancer diagnosis is presented based on a random forest (RF) classifier with ReliefF feature selection. Using preprocessing, segmentation, and feature extraction, 20 features were extracted. In the feature selection phase, 20 features were ranked according to weight using ReliefF. In the classification phase, the RF method was used as a classifier, and different dimensions of features were selected to train the classifier. To examine the efficacy of the proposed method, the Herlev data set collected at Herlev
Majority of the patients (58%) in our study were above 40 years old. Data from cancer registries in developing countries reported the same finding; 80%-90% of women with cervical cancer in the developing countries were above the age of 40 [12]. Eighty percent of women with cervical cancer in developing countries are diagnosed at advanced stages [13]. In our study, 47 patients (56.6%) presented with cervical cancer at stage III and IV, and these results were similar to other reports [14,15]. This might be attributed to the lack of screening services in our country and women tend to seek medical advice only when they have developed symptoms. In England, 23.8% of 382 women were diagnosed in stages III and IV [16] which contributes to the longer survival [17].. Many series reported pelvic failure rate of (20%-25%) and distant failure rate of (10%-25%) after concurrent chemoradiotherapy [18-22]. Our study reported local recurrence rate of 31.2%, and distant metastasis of 20.8%. The high local ...
Title:Current Evidence and Potential Mechanisms of Therapeutic Action of PEDF in Cervical Cancer Treatment. VOLUME: 15 ISSUE: 5. Author(s):J. Han and J. Guo. Affiliation:Department of Obstetrics and Gynecology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiangzhilu, Daping, Yuzhong District, Chongqing 400042, P.R. China.. Keywords:Cervical cancer, pigment epithelium derived factor, angiogenesis, differentiation, apoptosis, immune, metastasis.. Abstract:Cervical cancer is the second leading gynecological malignancy threat to the health of women in the world. However, few improvements in the efficacy of treatments of cervical cancer have been reported for the recurrent and metastasis patterns. As an endogenous antitumor agent, pigment epithelium derived factor (PEDF) has attracted wide attention, and its sensitivity to estrogen suggests a special role in female tumors, including cervical cancer. This review aims to summarize recent findings, the role ...
Cervical cancer incidence and mortality have been reduced up to 80% in developed countries.1 Despite the absence of clinical trials, the relation between Pap-smear screening and reduction of cervical cancer incidence and mortality has been recognized.2. The decreased burden of disease has been attributed to screening coverage leading to increased effort for extending conventional cytology to all women worldwide. Although screening programs have been successful in developed nations, they have not fulfilled their objectives in the majority of developing countries.1,3 In Colombia, cervical cancer remains the first cause of cancer mortality and the second cause of cancer incidence among women.4. The lack of impact of conventional cytology in low and middle income countries has been linked to social and economic factors as well as deficiencies in program organization.5 Recent studies revealed that Pap-smear coverage does not correlate with trends of cervical cancer mortality in Latin America; ...
Cervical cancer incidence and mortality have been reduced up to 80% in developed countries.1 Despite the absence of clinical trials, the relation between Pap-smear screening and reduction of cervical cancer incidence and mortality has been recognized.2. The decreased burden of disease has been attributed to screening coverage leading to increased effort for extending conventional cytology to all women worldwide. Although screening programs have been successful in developed nations, they have not fulfilled their objectives in the majority of developing countries.1,3 In Colombia, cervical cancer remains the first cause of cancer mortality and the second cause of cancer incidence among women.4. The lack of impact of conventional cytology in low and middle income countries has been linked to social and economic factors as well as deficiencies in program organization.5 Recent studies revealed that Pap-smear coverage does not correlate with trends of cervical cancer mortality in Latin America; ...
If abnormal cells on the surface of the cervix spread deeper into the cervix, or to other tissues or organs, the disease is then called cervical cancer, or invasive cervical cancer. Cervical cancer occurs most often in women younger than the age of 50. It is different from cancer that begins in other parts of the uterus and requires different treatment. Most cervical cancers are squamous cell carcinomas and adenocarcinomas.. The mortality rates for cervical cancer have declined sharply as Pap screenings have become more prevalent. According to the American Cancer Society about 12,170 cases of invasive cervical cancer will be diagnosed in the U.S. during 2012. Some researchers estimate that noninvasive cervical cancer (also referred to as carcinoma in situ) is nearly four times more common than invasive cervical cancer.. ...
Title:Human Papillomavirus (HPV) Vaccines as an Option for Preventing Cervical Malignancies: (How) Effective and Safe?. VOLUME: 19 ISSUE: 8. Author(s):Lucija Tomljenovic, Jean Pierre Spinosa and Christopher A. Shaw. Affiliation:Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, 828 W. 10th Ave, Vancouver, BC, V5Z 1L8, Canada.. Keywords:HPV vaccines, Gardasil, Cervarix, adverse reactions, vaccine efficacy, vaccine safety, conflict of interests, clinical trials, cervical cancers, safety profile. Abstract:We carried out a systematic review of HPV vaccine pre- and post-licensure trials to assess the evidence of their effectiveness and safety. We find that HPV vaccine clinical trials design, and data interpretation of both efficacy and safety outcomes, were largely inadequate. Additionally, we note evidence of selective reporting of results from clinical trials (i.e., exclusion of vaccine efficacy figures related to study subgroups in ...
Background: The tumor-stroma ratio (TSR) represents the percentage of neoplastic cell components compared to the combined area of neoplastic cells and the surrounding tumor-induced stroma. A low TSR (predomination of stromal component) has been demonstrated to be an independent adverse prognostic factor in cancers of several organs. In cervical carcinoma patients, TSR has been evaluated in only one previous study with different histological types. The present study aimed to assess the prognostic value of TSR in early stage cervical cancer patients with adenocarcinoma histology only. Materials and Methods: Histological slides of patients with early stage (IB-IIA) cervical adenocarcinoma who underwent surgical treatment between January 2003 and December 2011 were reviewed. Patients who had received preoperative chemotherapy were excluded. TSR was categorized as low (,50%) and high (≥50%). Correlations between TSR and clinicopathological variables were evaluated. Prognostic values of TSR and ...
Extensive experimental and limited epidemiologic data suggest that adeno-associated viruses (AAV) can have antioncogenic activity and may be protective factors for the development of cervical cancer. To examine the association between AAV-2 IgG antibodies and cervical neoplasia in Spain and Colombia, we tested for AAV-2 antibodies using an ELISA assay for 109 women with invasive cervical cancer, 100 population-based controls age-matched to the invasive cases, 77 women with carcinoma in situ (CIN III) and 100 clinic-based controls age-matched to the CIN III cases. Human papillomavirus (HPV) DNA was detected in cervical exfoliated cells by polymerase chain reaction using HPV-L1 and GP5+/6+ consensus primers. The prevalence of AAV-2 antibody titers >100 was significantly lower in invasive cervical cancer cases than control participants. When comparing women with invasive cancer with controls or with CIN III cases, a pattern of decreasing cervical cancer risk with increasing AAV-2 titers was ...
Cervical cancer is the second most common malignancy in women worldwide and one of the leading causes of cancer mortality globally. In patients with invasive cervical cancer prognostic factors are of value for the choice of treatment, monitoring of treatment and follow-up. The most important clinical prognostic factors are stage, tumor volume, parametrial infiltration, vascular invasion, lymph node metastases, and distant metastases. An improved estimation of the prognosis of cervical cancer is desirable, especially in early cancer stages.. The aim of this research was to study possible associations between tumor markers, female sex steroids, smoking, S-phase fraction (SPF), and prognosis in invasive squamous cell cervical cancer (SCC). The study comprised 190 patients with SCC, stages IB-IV, admitted to the Department of Gynecologic Oncology at Norrland University Hospital in Umeå between September 1984 and October1990. Ten year mortality was estimated.. In study I, of a total of 103 patients, ...
The aim of the study was to calculate the proportion of women living with HIV among women with cervical cancer. The authors found that 5.8 percent of all new cervical cancer cases worldwide in 2018 were diagnosed in women with HIV infection. This corresponds to 33,000 cases per year, 85 percent of which occur in sub-Saharan Africa.. On the basis of the results, the team was also able to show that women with HIV are six times more likely to develop cervical cancer than women without HIV infection.. The association between cervical cancer and HIV is obvious, explains Prof. Dr. Dr. Andrea S. Winkler, Co-Head of the Center for Global Health. Cervical carcinomas are mostly caused by infections with human papillomavirus (HPV), which, like HIV, are sexually transmitted. Based on our results, one could assume that infection with HIV is a risk factor for infection with HPV. . South and East Africa are hardest hit. The regions of South and East Africa are hardest hit, with 63.8 percent (South Africa) ...
TY - JOUR. T1 - Adenocarcinoma of the Uterine Cervix. AU - Jerant, Anthony F. PY - 1997. Y1 - 1997. N2 - Background: Adenocarcinoma of the uterine cervix is an increasingly common cervical neoplasm that has received little attention in the primary care literature. The purpose of this paper is to describe an illustrative case that provides an excellent opportunity to review the symptoms, diagnostic pitfalls, treatment options, and prognosis of this important disease. Methods: Case report is described, along with results of a literature review using MEDLINE and pertinent references from retrieved articles. Results: The relative incidence of cervical adenocarcinoma has risen from 5 to 10 percent of all cervical neoplasms in the 1950s to 10 to 20 percent in recent series. Some studies have also reported an increasing absolute incidence linked to widespread oral contraceptive use. The diethylstilbestrol-associated clear-cell variant accounts for only 2 to 3 percent of cases. About 10 percent of ...
This January, Care to Care is proud to participate in National Cervical Health Awareness Month. Cervical cancer was once one of the most common causes of cancer death for women. However, the cervical cancer death rate has gone down by more than 50% over the last 40 years, mainly due to the increased use of the Pap test for screening and early detection. This amazing screening tool can find changes in the cervix before cancer ever develops, enabling doctors to treat pre-cancerous states. Unfortunately, not all women are getting screened. In 2012, 10% of US women ages 21-65 reported they had not been screened for cervical cancer in the last 5 years. According to the American Cancer Society (ACS), there will be an estimated 12,820 new cases of invasive cervical cancer diagnosed in 2017, with an estimated 4,210 deaths from the disease.. Another important fact that many may not know is that most cervical cancers are preventable! Nearly all cases of cervical cancers are caused by human papillomavirus ...
Quantitative human papillomavirus type 16 viral load and prognosis of cervical cancer treatment efficiency is considered in the article.
January marks Cervical Cancer Awareness Month and, in recognition of this, we are proud to present a range of some of the latest cervical cancer research published across BMCs oncology journals.. Despite being highly preventable through early screening methods and vaccination, cervical cancer remains the fourth most common cause of cancer among women worldwide.. Research into cervical cancer prevention, diagnostics, signaling pathways, and therapeutics is therefore crucial. The articles in this compilation have been curated by our cancer journal Editors and include the latest cervical cancer research from BMC in each of these four critical topics.. Cervical cancer prevention. ...
A change of cervical cancer screening algorithms to an HPV-based screening setting is discussed in many countries, due to higher sensitivity of HPV testing compared to cytology. Reliable triage methods are, however, an essential prerequisite in such a setting to avoid overtreatment and higher screening costs. In this study, a series of cervical scrapes collected in PreservCyt liquid-based cytology (LBC) medium from women with cervical cancer (n = 5), cervical intraepithelial neoplasia grade 1-3 (n = 74), and normal cytology (n = 201; further n = 352 collected in SureThin®) were assessed for methylation of the marker regions ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671 using the GynTect assay and compared to cobas® HPV and CINtec Plus® biomarker results. All samples from women with cervical cancer, 61.2% of CIN3, 44.4% of CIN2 and 20.0% of CIN1 cases were scored positive for the GynTect methylation assay. In contrast, all CIN, irrespective of severity grade, and carcinomas were positive by both,
... uterine cancer, prostate cancer[citation needed], lung cancer and cervical cancer. Other associated underlying malignancies ... It is likely directly induced by an underlying neoplasm secreting a growth factor. One candidate may be alpha-transforming ... Acanthosis Nigricans and Florid Cutaneous Papillomatosis in a Patient with Metastatic Cervical Cancer", Dermatol Sin, 22: 142- ...
... and Uterine Corpus Endometrial Carcinoma. MORT is silenced in cervical cancer and therefore may serve as an independent ... lymphoid neoplasm diffuse large B-cell lymphoma, pancreatic adenocarcinoma, rectum adenocarcinoma, skin cutaneous melanoma, ... Factor of low-expressed LncRNA ZNF667-AS1 for cervical cancer and inhibitory function on the proliferation of cervical cancer ...
They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... "Screening for Cervical Cancer". U.S. Preventive Services Task Force. 2003. Archived from the original on 23 December 2010.. ... Colon, uterine, small bowel, stomach, urinary tract Genetic testing for individuals at high-risk of certain cancers is ... Strongly recommends cervical cancer screening in women who are sexually active and have a cervix at least until the age of 65.[ ...
... and cervical cancer. Additionally, hematometra may develop as a complication of uterine or cervical surgery such as endometrial ... a biopsy of endometrial tissue can be taken to test for the presence of a neoplasm (cancer). Antibiotics may be given as ... Hematometra is usually treated by surgical cervical dilation to drain the blood from the uterus. Other treatments target the ... Other causes are acquired, such as cervical stenosis, intrauterine adhesions, endometrial cancer, ...
Cervical cancer, Uterine cancer, Endometrial cancer, Ovarian cancer) Cancer of the male genital organs (Carcinoma of the penis ... A urogenital neoplasm is a tumor of the urogenital system. Types include: Cancer of the breast and female genital organs: ( ...
In 1870 Gusserow was the first physician to describe a rare type of uterine cervical adenocarcinoma that is sometimes referred ... Among his better written efforts was Die Neubildungen des Uterus (Neoplasms of the uterus). Zur Lehre vom Stoffwechsel des ... Cytologic and Cytochemical features of Adenoma Malignum of the Uterine Cervix Libri.de (short biography of Adolf Gusserow). ...
Symptoms of cervical adenosarcoma, like uterine adenosarcoma, are characterized by abnormal bleeding. Treatment mainly consists ... Malignant neoplasms arising in endometriosis: clinicopathological study of 14 cases. Clin Exp Obstet Gynecol. 2004;31(4):302-4 ... Uterine adenosarcoma are a subtype of uterine sarcomas. Uterine sarcomas account for 3 to 9 % of uterine cancers, and 5.5 to 9 ... Uterine adenosarcoma commonly arise from the endometrium. Uterine adenosarcomas have the highest incidence in perimenopasual ...
Cervical dyskaryosis is classified into three degrees of severity: mild, moderate and severe. A further category is used to ... This may be followed by the development of a malignant neoplasm. Dyskaryosis is used synonymously with dysplasia, which is the ... ". "Dyskaryosis" is a term used for all squamous mucosal surfaces and commonly used for the uterine cervix condition in which ... Dyskaryosis means abnormal nucleus and refers to the abnormal epithelial cell which may be found in cervical sample. It is ...
Myung SK, Ju W, Kim SC, Kim H (October 2011). "Vitamin or antioxidant intake (or serum level) and risk of cervical neoplasm: a ... "Radical trachelectomy and pelvic lymphadenectomy with uterine preservation in the treatment of cervical cancer". American ... Stage 1A cervical cancer Stage 1B cervical cancer Stage 2A cervical cancer Stage 2B cervical cancer Stage 3B cervical cancer ... Cervical intraepithelial neoplasia, the potential precursor to cervical cancer, is often diagnosed on examination of cervical ...
... uterine cervical incompetence MeSH C13.371.852.150.131 - uterine cervical neoplasms MeSH C13.371.852.150.150 - uterine ... uterine cervical diseases MeSH C13.371.852.150.074 - uterine cervical dysplasia MeSH C13.371.852.150.112 - uterine cervical ... uterine cervical neoplasms MeSH C13.371.852.833 - uterine prolapse MeSH C13.371.852.904 - uterine rupture MeSH C13.371.852.904. ... uterine cervical neoplasms MeSH C13.371.820.800.418.937 - vaginal neoplasms MeSH C13.371.820.800.418.968 - vulvar neoplasms ...
"Uterine Neoplasms". Journal of the National Comprehensive Cancer Network. 7 (5): 498-531. doi:10.6004/jnccn.2009.0035. ISSN ... Cervix Cervical cancer Villoglandular adenocarcinoma Low mag. High mag. Nasu, K.; Takai, N.; Narahara, H. (Jun 2009). " ... 2004). "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature". ... Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix. ...
... islet cell Rectal cancer Bladder cancer Cervical cancer Endometrial cancer Extragonadal germ cell tumor Ovarian cancer Ovarian ... transitional cell cancer Urethral cancer Uterine sarcoma Vaginal cancer Vulvar cancer Wilms tumor Esophageal cancer Head and ... Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm ...
... (CIS), also known as in situ neoplasm, is a group of abnormal cells.[1][2] While they are a form of neoplasm[ ... Cervical squamous intraepithelial lesion (SIL), previously called cervical intraepithelial neoplasia (CIN), is a form of ... Dysplasia of the uterine cervix is removed by excision (cutting it out) or by burning with a laser. Bowen's disease of the skin ... "Understanding Cervical Changes" (PDF). National Cancer Institute. National Institute of Health. Retrieved 17 June 2014.. [ ...
... namely cervical cancer, endometrial cancer, and uterine sarcomas, plus non-cancerous uterine fibroids. However, cervical and ... note that not all tumors are neoplasms, and not all neoplasms are tumors, but together, the two terms cover all of the ... Uterine cancer[edit]. There is somewhat of a mismatch between this template and the linked Uterine cancer page. That page lists ... Yes, work is needed here, but the correct solution is to expand Uterine cancer, plus remove text about cervical and endometrial ...
The presence of a uterine fibroid versus an adnexal tumor is made. Fibroids can be mistaken for ovarian neoplasms. An uncommon ... Cervical fibroids are located in the wall of the cervix (neck of the uterus). Rarely, fibroids are found in the supporting ... The prevalence of uterine fibroids among teenagers is 0.4%. The incidence of uterine fibroids in Europe is thought to be lower ... Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the uterus. Most women have ...
The presence of a uterine fibroid versus an adnexal tumor is made. Fibroids can be mistaken for ovarian neoplasms. An uncommon ... In a hysteroscopic myomectomy (also called transcervical resection), the fibroid can be removed by either the use of a ... Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the uterus.[1] Most women ... The prevalence of uterine fibroids among teenagers is 0.4%.[7]. EuropeEdit. The incidence of uterine fibroids in Europe is ...
... neoplasm, most commonly cervical cancer, and hematologic disorders. Molar pregnancy (also called hydatiform mole) is a type of ... Besides placenta previa and placental abruption, uterine rupture can occur, which is a very serious condition leading to ... As well as cervical insufficiency defined as a midtrimester (14th-26th week) dilation of the cervix which may need medical ... Causes of bleeding before and during childbirth include cervicitis, placenta previa, placental abruption and uterine rupture. ...
... uterine cervical neoplasms MeSH C04.588.945.418.955 - vaginal neoplasms MeSH C04.588.945.418.968 - vulvar neoplasms MeSH ... genital neoplasms, female MeSH C04.588.945.418.365 - fallopian tube neoplasms MeSH C04.588.945.418.948 - uterine neoplasms MeSH ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ...
... uterine serous carcinoma, Fallopian tube serous carcinoma, cervical serous carcinoma, and primary peritoneal serous carcinoma ... cystic neoplasms: Serous microcystic adenoma. *Intraductal papillary mucinous neoplasm. *Mucinous cystic neoplasm ...
Uterine papillary serous carcinoma. *Endometrial intraepithelial neoplasia. *Uterine clear-cell carcinoma. Cervix. *Cervical ... If the patient is postmenopausal, she usually presents with abnormal uterine bleeding, and in some cases hemoperitoneum. ...
Brown-Séquard syndrome Cervical cancer Combined small-cell lung carcinoma Lung cancer Prostate cancer "small-cell carcinoma" at ... Small-cell carcinoma is an undifferentiated neoplasm composed of primitive-appearing cells. As the name implies, the cells in ... 2011). "Advanced small cell carcinoma of the uterine cervix treated by neoadjuvant chemotherapy with irinotecan and cisplatin ...
A cervical polyp is a common benign polyp or tumor on the surface of the cervical canal. They can cause irregular menstrual ... Some polyps are tumors (neoplasms) and others are non-neoplastic, for example hyperplastic or dysplastic. The neoplastic ones ... ISBN 978-1-900151-51-1. "Uterine polyps". MayoClinic.com. 2006-04-27. Retrieved 2007-10-20. Sternberg, Stephen S.; Stacey E. ... An endometrial polyp or uterine polyp is a polyp or lesion in the lining of the uterus (endometrium) that takes up space within ...
... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... cervical accessory tragus, wattle) Congenital erosive and vesicular dermatosis Congenital hypertrophy of the lateral fold of ... Multinucleate cell angiohistocytoma Multiple cutaneous and uterine leiomyomatosis syndrome (leiomyomatosis cutis et uteri, ... an overview with emphasis on the myeloid neoplasms". Chem. Biol. Interact. 184 (1-2): 16-20. doi:10.1016/j.cbi.2009.10.009. ...
External orifice of the uterus Cervical canal Internal orifice of the uterus Body (Latin: Corpus) Uterine cavity Fundus The ... malignant neoplasm Fibroids - benign neoplasms Adenomyosis - ectopic growth of endometrial tissue within the myometrium ... most commonly seen in dogs Uterine malformations mainly congenital malformations including Uterine Didelphys, bicornuate uterus ... During pregnancy, the uterine glands and blood vessels in the endometrium further increase in size and number and form the ...
He was the first man in this country to advocate radium as the agent of choice in cervical carcinoma; the technique of burying ... Janeway's 1919 paper on "The Treatment of Uterine Carcinoma" was considered a classic and was written while he was Attending ... A Model for a Curable Neoplasm" 2010 Charles M. Balch, M.D., Johns Hopkins Medical Institute - "Melanoma as an Example of ... Janeway, M.D., Henry H. (September 1919). "The Treatment of Uterine Cancer by Radium". Surgery, Gynecology, and Obstetrics. 24 ...
... in cervical carcinoma and cervical intraepithelial neoplasm". Anticancer Research. 23 (4): 3195-8. PMID 12926053. Iwasa S, Jin ... and uterine stroma. FAP expression is high in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing ...
Uterine papillary serous carcinoma. *Endometrial intraepithelial neoplasia. *Uterine clear-cell carcinoma. Cervix. *Cervical ... Uterine adenomyoma[edit]. In obstetrics and gynecology contexts, it is a form of adenomyosis that forms a mass or growth around ...
There are four main groups of vaginal neoplasms: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... "What Is Uterine Sarcoma?". www.cancer.org. Retrieved 2018-02-28.. *^ Schoolmeester JK, Xing D, Keeney GL, Sukov WR (July 2017 ... p. Neoplasm. ISBN 0781733901.. *^ "NCI Dictionary of Cancer Terms - Neoplasm". National Cancer Institute. Retrieved 2018-03-13. ... Vaginal tumors are neoplasms (tumors) found in the vagina. They can be benign or malignant.[1][a] A neoplasm is an abnormal ...
Uterus prior to hysterectomy Laparoscopical hysterectomy Cervical stump (white) after removal of the uterine corpus at ... "Peritoneal Dissemination Complicating Morcellation of Uterine Mesenchymal Neoplasms". PLOS ONE. 7 (11): e50058. Bibcode: ... where the uterine lining has grown into and sometimes through the uterine wall musculature. This can thicken the uterine walls ... It is not effective for patients with very thick uterine lining or uterine fibroids. Levonorgestrel intrauterine devices are ...
Cervical cancer. *Cholangiocarcinoma. *Chordoma. *Chronic lymphocytic leukemia. *Chronic myeloid leukemia. *Clear-cell sarcoma ... Salivary gland neoplasm. *Sarcoma. *Skin cancer. *Small intestine cancer. *Small-cell carcinoma ...
en:Neoplasm (40) → 신생물 *en:Nephrotic syndrome (38) → 신증후군 *en:Nervous system disease (4) ... en:Cervical screening (4). *en:Charles Schepens (4). *en:Chest pain (26) ... en:Uterine cancer (23) → 자궁암 *en:Vaccine hesitancy (21). *en:Vaginal delivery (10) ...
Ischemic placental disease leads to the attachment of the placenta to the uterine wall to become under-perfused, causing ... Trophoblastic neoplasms derive from trophoblastic tissue. Examples include: *Choriocarcinoma. *Hydatidiform mole. Mechanism[ ... rapid acceleration and deceleration and uterine compression increase the risk of placental abruption, in turn leading to ...
Cervical polyp[edit]. Main article: Cervical polyp. A cervical polyp is a common benign polyp or tumor on the surface of the ... "Uterine polyps". MayoClinic.com. 2006-04-27. Retrieved 2007-10-20.. *^ Sternberg, Stephen S.; Stacey E. Mills; Darryl Carter ( ... Some polyps are tumors (neoplasms) and others are nonneoplastic (for example, hyperplastic or dysplastic). The neoplastic ones ... An endometrial polyp or uterine polyp is a polyp or lesion in the lining of the uterus (endometrium) that takes up space within ...
Uterine papillary serous carcinoma. *Endometrial intraepithelial neoplasia. *Uterine clear-cell carcinoma. Cervix. *Cervical ... Neoplasms of the Vulva and Vagina. in Holland-Frei Cancer Medicine - 6th Ed. Kufe, DW et al. editors. BC Decker Inc., Hamilton ...
Uterine papillary serous carcinoma. *Endometrial intraepithelial neoplasia. *Uterine clear-cell carcinoma. Cervix. *Cervical ... Ovarian neoplasms Germ cell tumor Seen most often in young women or adolescent girls. Other germ cell tumors are: Endodermal ...
They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... Cervical cancer may require birth by Caesarean section. Radiation to the breast reduces the ability of that breast to produce ... In a few instances, such as advanced uterine cancer, the pregnancy cannot be continued and in others, the patient may end the ... It is used to treat basal cell skin cancer and the very early stages of others like cervical, penile, vaginal, vulvar, and non- ...
Uterine artery embolization (UAE) or uterine fibroid embolization (UFE) Prostate artery embolization (PAE) Pulmonary ... Used to treat patients with radicular symptoms in the cervical, thoracic, lumbar or sacral region. Helps to alleviate pain by ... such as osteoporosis or underlying neoplasm. Analogous to vertebroplasty, the purpose of sacroplasty is to provide ...
... in treatment of infertility in women when there is a need to develop sperm-friendly cervical mucous or an appropriate uterine ... "Pharmacology and Clinical Utility of Hormones in Hormone Related Neoplasms". In Alan C. Sartorelli, David G. Johns (eds.). ...
The narrow, central cervical canal runs along its entire length, connecting the uterine cavity and the lumen of the vagina. The ... Papillary - In oncology, papillary refers to neoplasms with projections ("papillae", from Latin, 'nipple') that have ... Cervical cancer - is a cancer arising from the cervix. It is due to the abnormal growth of cells that have the ability to ... Brachial plexus - is a network of nerves formed by the ventral rami of the lower four cervical nerves and first thoracic nerve ...
They can develop further into a variety of other neoplasms, including choriocarcinoma, yolk sac tumor, and teratoma. They occur ... Histologically, they are similar to intestinal or cervical adenocarcinomas and are often actually metastases of appendiceal or ... CA-125 may also be elevated in benign (non-cancerous) conditions, including endometriosis, pregnancy, uterine fibroids, ... More typically, ovarian squamous cell carcinomas are cervical metastases, areas of differentiation in an endometrioid tumor, or ...
All MeSH CategoriesDiseases CategoryNeoplasmsNeoplasms by SiteUrogenital NeoplasmsGenital Neoplasms, FemaleUterine Neoplasms ... FemaleUterine DiseasesUterine Cervical DiseasesUterine Cervical Neoplasms. All MeSH CategoriesDiseases CategoryFemale ... FemaleUterine DiseasesUterine NeoplasmsUterine Cervical Neoplasms. All MeSH CategoriesDiseases CategoryFemale Urogenital ... Diseases and Pregnancy ComplicationsFemale Urogenital DiseasesUrogenital NeoplasmsGenital Neoplasms, FemaleUterine Neoplasms ...
Cervical cancer control in developing countries : memorandum from a WHO meeting  WHO Consultation on the Control of Cervical ... Cervical cancer screening in developing countries : report of a WHO consultation  World Health Organization (‎World Health ... Cervical cancer screening programmes : managerial guidelines / A. B. Miller  Miller, Anthony B; World Health Organization (‎ ... Comprehensive cervical cancer control: a guide to essential practice  World Health Organization (‎World Health Organization, ...
Pfizer is currently recruiting for the NCT00136955 Uterine Cervical Neoplasms Cancer trial. Review trial description, criteria ...
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S ... Strengthening cervical cancer prevention in Europe : meeting of policy-makers and programme managers, Copenhagen, Denmark, 29- ... Review and reorientation of the Serbian national programme for early detection of cervical cancer towards greater health equity ...
"Uterine Cervical Neoplasms" by people in this website by year, and whether "Uterine Cervical Neoplasms" was a major or minor ... "Uterine Cervical Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Uterine Cervical Neoplasms*Uterine Cervical Neoplasms. *Cervical Neoplasm, Uterine. *Cervical Neoplasms, Uterine ... Below are the most recent publications written about "Uterine Cervical Neoplasms" by people in Profiles. ...
Regional Workshop on Cervical Cancer Control and HPV Vaccination, Manila, Philippines, 28-30 November 2011 : meeting report  ... Regional Meeting on Elimination of Cervical Cancer in the Western Pacific, Manila, Philippines, 24-25 June 2019 : meeting ... Expert Consultation on the Comprehensive Prevention and Control of Cervical Cancer, Kuala Lumpur, Malaysia, 4 - 6 November 2009 ... "Uterine Cervical Neoplasms". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. Z. * 0-9 ...
Vaginal carcinoma after cervical dysplasia Mikel Gorostidi, Arantza Lekuona, Arantxa Juaristi, Glauco Baiocchi ... ESGO contribution to the WHO initiative on elimination of cervical cancer Murat Gultekin, Philippe Morice, Nicole Concin, Denis ... Updates and management algorithm for neuroendocrine tumors of the uterine cervix Gloria Salvo, Antonio Gonzalez Martin, Naomi R ... Role of primary care enrolment in advanced cervical cancer diagnosis: a population-based case-control study Laurence Bernard, ...
Uterine. Cervical. Neoplasms. */diagnosis Uterine. Cervical. Neoplasms. */metabolism Uterine. Cervical. Neoplasms. */pathology ... Uterine. Cervical. Neoplasms. /epidemiology ; Uterine. Cervical. Neoplasms. /prevention & control ; Young Adult. Czasopismo ... Uterine. Cervical. Neoplasms. /*diagnosis Uterine. Cervical. Neoplasms. /*prevention & control Vaginal Smears. /*psychology. ... Uterine. Cervical. Neoplasms. /mortality ; Uterine. Cervical. Neoplasms. /virology ; Young Adult. Czasopismo naukowe ...
Results of search for su:{Uterine cervical neoplasms} Refine your search. *Availability * Limit to currently available items. ... Screening for cancer of the uterine cervix / from the IARC Working Group on Cervical Cancer Screening and the UICC Project ... Second cancer in relation to radiation treatment for cervical cancer / from the International Radiation Study Group on Cervical ... Cervical screening : a practical guide / Ann McPherson.. by McPherson, Ann Material type: Book; Format: print Publisher: Oxford ...
Uterine Cervical Neoplasms. Uterine Neoplasms. Genital Neoplasms, Female. Urogenital Neoplasms. Neoplasms by Site. Neoplasms. ...
Uterine Cervical Diseases. Uterine Diseases. Carcinoma in Situ. Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by ... Uterine Cervical Dysplasia. Cervical Intraepithelial Neoplasia. DNA Virus Infections. Virus Diseases. Tumor Virus Infections. ... cervical cytology and HPV testing as cervical screening tools in Latin America. This report refers to partial results from the ... Impact of AV2 Antiviral Drug on the Treatment of HPV-associated Lesions of the Uterine Cervix (KINVAV). The safety and ...
Uterine Cervical Neoplasms. Uterine Neoplasms. Genital Neoplasms, Female. Urogenital Neoplasms. Neoplasms by Site. Neoplasms. ... Uterine Cervical Diseases. Uterine Diseases. Gemcitabine. Irinotecan. Pemetrexed. Topotecan. Vinorelbine. Antimetabolites, ... Cervical Cancer Drug: tisotumab vedotin Drug: topotecan Drug: vinorelbine Drug: gemcitabine Drug: irinotecan Drug: pemetrexed ... Tisotumab Vedotin vs Chemotherapy in Recurrent or Metastatic Cervical Cancer (innovaTV 301). The safety and scientific validity ...
Neoplasms. Uterine Neoplasms. Genital Neoplasms, Female. Urogenital Neoplasms. Neoplasms by Site. Uterine Cervical Diseases. ... Uterine Cervical Neoplasms. Vaginal Neoplasms. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. ... Stage IB2 Cervical Cancer AJCC v8 Stage II Cervical Cancer AJCC v8 Stage II Vaginal Cancer AJCC v8 Stage IIA Cervical Cancer ... Stage IIA2 Cervical Cancer AJCC v8 Stage IIB Cervical Cancer AJCC v8 Stage IIB Vaginal Cancer AJCC v8 Stage III Cervical Cancer ...
Uterine Cervical Neoplasms. D002583. EFO:0001416. cervical adenocarcinoma. 2. ClinicalTrials. Breast Neoplasms. D001943. EFO: ... Colorectal Neoplasms. D015179. EFO:0004142. colorectal neoplasm. 3. ClinicalTrials. Genital Neoplasms, Female. D005833. EFO: ... Neoplasms. D009369. EFO:0000616. neoplasm. 4. ATC. ClinicalTrials. Scleroderma, Systemic. D012595. EFO:0000717. systemic ... Appendiceal Neoplasms. D001063. EFO:0003880. appendiceal neoplasm. 2. ClinicalTrials. Carcinoma, Non-Small-Cell Lung. D002289. ...
Uterine cervical neoplasms - virology 5. Endpoint determination - therapeutic use ... Anal cancer and cervical cancer share a similar association with HPV. *7.3. The association between HPV infection and anal ... HPV etiology of cervical versus oropharyngeal cancers. *8.3. Sex-based differences in incidence of HPV-positive oropharyngeal ... Histopathological progression of cervical cancer versus oropharyngeal cancer. *8.6. Prevention of oral HPV infection and ...
Uterine Cervical Neoplasms. en_US. dc.subject.mesh. Early Detection of Cancer. en_US. ... Implementation of post-market surveillance in cervical cancer programmes: policy brief for manufacturers of medical devices, ... genotypes in cervical cancer screening. dc.contributor.author. World Health Organization. en_US. ... and scaling up testing for human papillomavirus as part of a comprehensive programme for prevention and control of cervical ...
... tumor and not with high intratumor microvessel density in 40 patients with advanced squamous cell carcinoma of the uterine ... Uterine Cervical Neoplasms / blood supply * Uterine Cervical Neoplasms / metabolism * Uterine Cervical Neoplasms / radiotherapy ... Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: relationships to pretreatment tumor oxygenation ... tumor and not with high intratumor microvessel density in 40 patients with advanced squamous cell carcinoma of the uterine ...
... accuracy of cervical biopsies was found to be closely related to the extent and the degree of differentiation of the neoplasm. ... In this study of 58 cervical in situ and invasive adenocarcinomas, the diagnostic ... In this study of 58 cervical in situ and invasive adenocarcinomas, the diagnostic accuracy of cervical biopsies was found to be ... Diagnostic problems of in situ and invasive adenocarcinomas of the uterine cervix Appl Pathol. 1987;5(1):47-56. ...
Uterine Neoplasms; Version 2.2012 - Cervical Cancer; Version 1.2013 - Kidney Cancer; Version 1.2013 - Central Nervous System ...
Uterine pathology, particularly endometrial carcinoma, is common in postmenopausal women with abnormal uterine bleeding. Thus, ... In premenopausal women with normal findings on physical examination, the most likely diagnosis is dysfunctional uterine ... The most probable etiology of abnormal uterine bleeding relates to the patients reproductive age, as does the likelihood of ... vulvar or vaginal pathology and cervical lesions or polyps. Bimanual uterine examination may reveal enlargement from uterine ...
ClinicalTrials.gov summary of Storytelling Intervention to Promote Cervical Cancer Screening Uptakes Among Malawian Women ... Uterine Cervical Neoplasms ClinicalTrials.gov processed this data on May 24, 2020 This information is provided by ... are no prior cervical cancer screening * are no history of invasive cervical cancer * are willingness to participate in the ... cervical cancer screening, 5) no history of invasive cervical cancer, and 6) willingness to participate in the study. The age ...
urethral neoplasm. 3. ClinicalTrials. ClinicalTrials. Uterine Cervical Neoplasms. D002583. EFO:0001061. cervical carcinoma. 2. ... Uterine Neoplasms. D014594. EFO:0003859. uterine neoplasm. 3. ClinicalTrials. Lymphohistiocytosis, Hemophagocytic. D051359. ... Ovarian Neoplasms. D010051. EFO:0003893. ovarian neoplasm. 3. ClinicalTrials. ClinicalTrials. Pancreatic Neoplasms. D010190. ... Nasopharyngeal Neoplasms. D009303. EFO:0004252. nasopharyngeal neoplasm. 2. ClinicalTrials. Neoplasms. D009369. EFO:0000311. ...
Uterine Cervical Neoplasms. *Ovarian Neoplasms. *Peritoneal Neoplasms. *Fallopian Tube Neoplasms. *Adenoma. *Neurotoxicity ... neuropathy in women with ovarian, peritoneal, cervical, fallopian tube, uterine, or. endometrial cancer treated with cisplatin ... DISEASE CHARACTERISTICS: Ovarian, primary peritoneal, cervical, or fallopian tube. carcinoma, uterine sarcoma, or endometrial ... Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Neurotoxicity, Ovarian Cancer, Primary Peritoneal Cavity Cancer, ...
Squamous microcarcinomas of the uterine cervix represent a focus of controversy regarding a useful clinical definition. The ... Neoplasm Staging. Retrospective Studies. Risk Factors. Uterine Cervical Neoplasms / pathology*, surgery*. From MEDLINE®/PubMed ... 7283829 - Management of cervical thorium dioxide granulomas.. 19525829 - Cervical chordoma in childhood without typical ... This report analyses retrospectively 133 cases of Stage IA cervical cancers which have been followed up for 10-240 months. The ...
Uterine cervical neoplasm. ... Cervical uterine cancer is the second most common malignancy ... The results indicate the need of extending periodic cervical cancer screening for all women, reducing the inequalities still ...
Uterine Cervical Neoplasms, therapy. Cervical Intraepithelial Neoplasia, therapy. Conization. Electrocoagulation. Cross- ... Cervical cancer prevention and control strategies in Brazil have been planned based on distribution of cervical lesions by age ... RESULTS: There were 168 cases of cervical high-grade cervical squamous intraepithelial lesions, of these, 31 were treated with ... The most effective approach to cervical cancer control is early diagnosis and treatment of precursor lesions called cervical ...
We evaluated the impact of conization margin status on outcomes of patients diagnosed with cervical adenocarcinoma in situ. ... Neoplasm, Residual. Predictive Value of Tests. Retrospective Studies. Uterine Cervical Neoplasms / pathology*. ... OBJECTIVE: We evaluated the impact of conization margin status on outcomes of patients diagnosed with cervical adenocarcinoma ...
Most cervical cancer is caused by the HPV virus. It can often be cured if found early - learn how. ... ClinicalTrials.gov: Uterine Cervical Neoplasms (National Institutes of Health) Journal Articles References and abstracts from ... Surgery for Cervical Cancer (American Cancer Society) Also in Spanish * Treatment Option Overview (Cervical Cancer) (National ... Cervical cancer -- screening and prevention (Medical Encyclopedia) Also in Spanish * Cervical dysplasia (Medical Encyclopedia) ...
Cervical Cancers. *Non-Epithelial Ovarian Tumours. *Uterine Cervical Neoplasms. *Genital Neoplasms, Female ... Cancer of the Ovary Treated as 2nd Line Therapy, Muellerian Mixed Tumours, Tumours of the Uterus, Cervical Cancers, Non- ...
Uterine Cervical Neoplasms treatment. ISO. RGD:1315034. 9068941. RGD. PMID:17308115, REF_RGD_ID:2293193. ... Uterine Cervical Neoplasms ISO. RGD:1315034. 9068941. RGD. PMID:12687273, REF_RGD_ID:2293200. ... associated with Cervix Neoplasms. RGD. PMID:17233814, REF_RGD_ID:2293196. Mammary Neoplasms, Experimental ISO. RGD:1306426. ... associated with Breast Neoplasms, mRNA:increased expression:breast. RGD. PMID:18483361, REF_RGD_ID:2293190. ...
  • These precursor lesions are either called precancerous lesions, dysplasia or cervical intraepithelial neoplasia (CIN). (clinicaltrials.gov)
  • To determine the rates of cervical intraepithelial neoplasia grade 2 or more and of false positives for colposcopy and direct visual inspection. (scielo.org.co)
  • Tissue alterations due to these atrophic changes, trauma, erythema, and microvascularization can be confused with cervical intraepithelial neoplasia. (medscape.com)
  • Upon examination, she was found disease- Introduction free in the right eye but displayed a left conjunctival intraepithelial neoplasia (CIN grade I) and low-grade Ocular surface squamous neoplasia (OSSN) is among cervical squamous dysplasia. (deepdyve.com)
  • RATIONALE: Diagnostic procedures, such as digital colposcopy, may help doctors find and diagnose cervical intraepithelial neoplasia. (bioportfolio.com)
  • A direct way of contracting this cancer is a smoker has a higher chance of cervical intraepithelial neoplasia (CIN3) occurring, which has the potential of forming cervical cancer. (wikipedia.org)
  • Analizar la asociación entre la conducta conservadora en lesión intraepitelial cervical de alto grado con el índice de reincidencia de la neoplasia y grupo etario. (scielo.br)
  • Determinar las tasas de detección de neoplasia intraepitelial cervical de grado 2 y de los falsos positivos en la colposcopia y la inspección visual directa. (scielo.org.co)
  • and cervical human papillomavirus (HPV)-related squamous neoplasia. (deepdyve.com)
  • OBJECTIVES: I. Determine the efficacy of amifostine in reducing significant peripheral neuropathy in women with ovarian, peritoneal, cervical, fallopian tube, uterine, or endometrial cancer treated with cisplatin and paclitaxel. (knowcancer.com)
  • This study will test the feasibility and acceptability of a yoga program for women with gynecologic malignancies such as ovarian, endometrial, or cervical cancer. (bioportfolio.com)
  • Clinicopathologic studies in endometrial carcinoma, ovarian neoplasms, and soft tissue tumors. (stanford.edu)
  • Cancers that are known to have a hereditary link are breast cancer, colon cancer, ovarian cancer , and uterine cancer. (thefreedictionary.com)
  • The ability of radiotherapy or surgery to cure locally advanced cervical cancer is limited by the size of the tumour, high incidence of pelvic lymph node metastases and potential for systemic spread. (knowcancer.com)
  • Recent data from prospective randomised trials and two meta-analyses (3-12) has unequivocally shown significant survival advantage (both disease free and overall survival) with the use of concurrent chemoradiation using platinum based chemotherapy compared to radical radiation alone in patients with locally advanced cervical cancer (stages IB2-IIIB). (knowcancer.com)
  • This has led to acceptance of concurrent chemoradiation therapy as the new standard of care for locally advanced cervical cancer. (knowcancer.com)
  • Downregulation of nuclear and cytoplasmic Chibby is associated with advanced cervical cancer. (amedeo.com)
  • This trial studies how well magnetic resonance imaging (MRI)-guided internal radiation therapy (brachytherapy) works in treating participants with human papillomavirus (HPV) associated stage IB2-IV cervical or stage II-IVA vaginal cancer. (clinicaltrials.gov)
  • To review and summarise current controversies in cervical screening in Hong Kong and discuss the potential impact of prophylactic human papillomavirus vaccination. (hkmj.org)
  • The new human papillomavirus vaccine, combined with an organised screening programme, is probably a more cost-effective way of preventing morbidity and mortality due to cervical cancer than the current programme in Hong Kong. (hkmj.org)
  • The development of the human papillomavirus (HPV) prophylactic vaccines marks a significant scientific and technological breakthrough in the fight against cervical cancer. (scielosp.org)
  • Human Papillomavirus 18 Genetic Variation and Cervical Cancer Risk Worldwide. (nextbio.com)
  • Human papillomavirus and Epstein-Barr virus co-infection in cervical carcinoma in Algerian women. (nih.gov)
  • Despite the fact that the implication of human papillomavirus (HPV) in the carcinogenesis and prognosis of cervical cancer is well established, the impact of a co-infection with high risk HPV (HR-HPV) and Epstein-Barr virus (EBV) is still not fully understood. (nih.gov)
  • Variants of the long control region and the E6 oncogene in European human papillomavirus type 16 isolates: implications for cervical disease. (nih.gov)
  • Epidemiological and experimental studies have provided evidence that human papillomavirus (HPV) infection is a main player in the development of uterine cervical neoplasms. (spandidos-publications.com)
  • Effect of Several Negative Rounds of Human Papillomavirus and Cytology Co-testing on Safety Against Cervical Cancer: An Observational Cohort Study. (amedeo.com)
  • Cervical Cancer Screening: The Transformational Role of Routine Human Papillomavirus Testing. (amedeo.com)
  • Metastasis from various neoplasms to the spleen is very rare and most of the cases are found at autopsy. (hindawi.com)
  • She underwent a splenectomy and the result of histology was compatible with metastasis of cervical cancer. (hindawi.com)
  • The result of pathological examination was compatible with metastasis from cervical cancer (Figure 5 ). (hindawi.com)
  • Two of these enzymes, MMP-2 and MMP-9, have been correlated with the processes of tumor cell invasion and metastasis in human cancers, including uterine neoplasms. (spandidos-publications.com)
  • The long non-coding RNA CRNDE promotes cervical cancer cell growth and metastasis. (amedeo.com)
  • Risk stratification models for para-aortic lymph node metastasis and recurrence in stage IB-IIB cervical cancer. (amedeo.com)
  • Quality and quantity metrics of pelvic lymph node metastasis and risk of para-aortic lymph node metastasis in stage IB-IIB cervical cancer. (amedeo.com)
  • Tumors or cancer of the UTERINE CERVIX. (nih.gov)
  • Lower levels of miR-183 have been observed in diverse types of tumors but the mechanism and precise function of miR-183-5p in cervical cancer have largely not been investigated. (medscimonit.com)
  • Malignant tumors of gynecologic origin commonly spread to the bones, lungs, local cervical region and the supra-clavicular lymph nodes, while gynecologic metastases to the thoracic region are rarely seen in clinical practice. (minervamedica.it)
  • Cancers associés aux virus en Afrique. (who.int)
  • This report analyses retrospectively 133 cases of Stage IA cervical cancers which have been followed up for 10-240 months. (biomedsearch.com)
  • Chemotherapy has been used in the management of locally advanced cervical cancers along with radiation therapy and surgery in different ways e.g. neoadjuvant, adjuvant and concurrent. (knowcancer.com)
  • Cervical cancer is one of the most common cancers in Hong Kong, and can be prevented if detected at its pre-cancerous stage. (hkmj.org)
  • This meeting focused on the new trends in the management of cervical cancer, fertility-sparing management of gynecologic cancers, surgical management of gynecologic cancers, and recent advances in translational research on gynecologic cancers. (koreamed.org)
  • As many as 5% of cervical cancers may not be associated with HPV. (medscape.com)
  • Many cervical cancers occurs among women over 65 and prevalence of HPV genotypes in this age cohort is sparingly studied. (diva-portal.org)
  • HPV vaccines protect against two to seven high-risk strains of this family of viruses and may prevent up to 90% of cervical cancers. (wikipedia.org)
  • About 70% of cervical cancers and 90% of deaths occur in developing countries. (wikipedia.org)
  • The high rate of HR-HPV and EBV co-infection in SCC suggests that EBV infection is incriminated in cervical cancer progression. (nih.gov)
  • The most probable etiology of abnormal uterine bleeding relates to the patient's reproductive age, as does the likelihood of serious endometrial pathology. (aafp.org)
  • Uterine pathology, particularly endometrial carcinoma, is common in postmenopausal women with abnormal uterine bleeding. (aafp.org)
  • Dysfunctional uterine bleeding (DUB), defined as abnormal uterine bleeding not caused by pelvic pathology, medications, systemic disease or pregnancy, is the most common cause of abnormal uterine bleeding but remains a diagnosis of exclusion. (aafp.org)
  • Adenocarcinoma in situ of the uterine cervix: Clinical practice guidelines from the Italian society of colposcopy and cervical pathology (SICPCV). (bioportfolio.com)
  • A retrospective review of pathology reports to identify women undergoing anterior pelvic exenteration for UC was performed (N=221), and incidentally discovered gynecologic tract neoplasms were recorded. (bireme.br)
  • Cytological screening in the control of cervical cancer : technical guidelines. (who.int)
  • abstract = "The adenocarcinoma cell line HeLa serves as a model system for cancer research in general and cervical cancer in particular. (qub.ac.uk)
  • Using MRI guidance during brachytherapy applicator placement may improve treatment planning in participants with cervical or vaginal cancer. (clinicaltrials.gov)
  • Uterine cervical neoplasm/ Brachytherapy/ Constriction pathologic/ Nursing. (index-f.com)
  • Computed tomography-based image-guided brachytherapy for cervical cancer: correlations between dose-volume parameters and clinical outcomes. (amedeo.com)
  • Clark JL, Lu D, Kalir T, Liu Y. Overdiagnosis of HSIL on cervical biopsy: errors in p16 immunohistochemistry implementation. (umassmed.edu)
  • A cervical biopsy was performed and the pathological examination of the biopsy showed undifferentiated carcinoma (Figure 1 ). (hindawi.com)
  • Direct visual inspection for cervical cancer screening remains controversial, whereas colposcopy-biopsy is considered the gold standard for diagnosis of preneoplastic cervical lesions. (scielo.org.co)
  • The diagnosis of cervical cancer is performed with the cervical biopsy which is guided by the colposcopy. (bioportfolio.com)
  • Diagnosis is typically by cervical screening followed by a biopsy. (wikipedia.org)
  • Poor outcome of treatment was found to be associated with low oxygen tension in the primary tumor and not with high intratumor microvessel density in 40 patients with advanced squamous cell carcinoma of the uterine cervix. (nih.gov)
  • This image shows a hypoattenuating tumor occupying the entire cervix and extending to the outer posterior and right cervical margins. (medscape.com)
  • Stomatin-like protein 2 is overexpressed in cervical cancer and involved in tumor cell apoptosis. (amedeo.com)
  • A urogenital neoplasm is a tumor of the urogenital system. (wikipedia.org)
  • Microinvasive carcinoma of the uterine cervix. (biomedsearch.com)
  • MR is a relatively promising method for staging and evaluating extent of disease in carcinoma of the uterine cervix. (koreamed.org)
  • These factors, which may well have affected the epidemiology of cervical cancer, taken together with the recent incorporation of HPV vaccination strategies render it necessary for the pertinent tumour burden status to be updated in Spain, so as to be able to assess the future impact of preventive measures. (biomedcentral.com)
  • In premenopausal women with normal findings on physical examination, the most likely diagnosis is dysfunctional uterine bleeding (DUB) secondary to anovulation, and the diagnostic investigation is targeted at identifying the etiology of anovulation. (aafp.org)
  • Data was collected from medical records, and the variables definitive diagnosis, type of treatment provided, occurrence of high-grade cervical squamous intraepithelial lesions and recurrence were studied. (scielo.br)
  • to provide a practical tool for the evidenced-based management of adenocarcinoma in situ (AIS) of the uterine cervix, a challenging diagnosis encountered by colposcopists in their daily practice. (bioportfolio.com)
  • The clinical value of PET and PET/CT in the diagnosis and management of suspected cervical cancer recurrence. (amedeo.com)
  • Clinically, the differential diagnosis included recurrent cervical cancer, bladder cancer and retroperitonal sarcoma. (springermedizin.de)
  • The objective of this case report was to describe the ultrasonographic, surgical, and histopathological findings of a rare clinical case of uterine leiomyoma in a 5-year-old Holstein crossbred cow presented for diagnosis and treatment of infertility. (hindawi.com)
  • Ultrasonography enabled prompt, noninvasive diagnosis of uterine leiomyoma and proved to be a useful decision-making tool in the abdominal surgery of the cow. (hindawi.com)
  • and, b) access to and effectiveness of programmes for the early diagnosis and treatment of precancerous lesions, which can reduce the incidence of invasive cervical cancer in screened groups by approximately 80% [ 4 ]. (biomedcentral.com)
  • Despite the advantages of MRI, the gynecology literature mostly recommends the use of CT scanning for the pretreatment evaluation of cervical cancer. (medscape.com)
  • Advancing the evaluation of cervical cancer screening: development and application of a longitudinal adherence metric. (amedeo.com)
  • At the Tata Memorial Hospital, approximately 1600 new patients with cervical cancer are registered every year, of which nearly 70% present in locally advanced stages. (knowcancer.com)
  • Conclusion: Downregulating ER-α expression may be a potential treatment regimen for cervical cancer patients and will be of great significance for patients with cervical cancer who are receiving conventional treatment for nonsurgical treatments. (eurekaselect.com)
  • BACKGROUND Cervical cancer (CC) is the third most common cancer in women, and the seventh overall, with an estimated 530 000 new cases per year. (clinicaltrials.gov)
  • The concurrent use of single drug and multiple drug regimens with radiotherapy has been tested in women with cervical cancer. (knowcancer.com)
  • Ping Yu, Yuping Wang, Chuanxun Li, Li Lv* and Jihong Wang*, "Protective Effects of Downregulating Estrogen Receptor Alpha Expression in Cervical Cancer", Anti-Cancer Agents in Medicinal Chemistry (2018) 18: 1975. (eurekaselect.com)
  • Previous studies have indicated that malignant cervical cells tend to lose Estrogen Receptor alpha (ER-α) expression in the cervical epithelium while maintaining ER-α expression in the stromal cells. (eurekaselect.com)
  • Uterine Cervical Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • To develop a theory-based culturally-grounded storytelling-based intervention to increase cervical cancer screening among Malawian women living with HIV infection. (nih.gov)
  • Secondary objectives: To conduct a pilot randomized clinical trial (RCT) to examine the acceptability, feasibility and preliminary effectiveness of narrative intervention on cervical cancer screening prevention behavior. (nih.gov)
  • Development of Narrative Video: The investigators will first develop culturally-grounded and human-centered storytelling narrative intervention videos in Chichewa, the local language to address sociocultural and individual factors which influence cervical cancer prevention behaviors. (nih.gov)
  • The project will involve two phases: Phase 1: The investigators will produce culturally-grounded and human-centered storytelling narrative intervention videos to address sociocultural and individual factors which influence cervical cancer prevention behaviors. (nih.gov)
  • Detection rates for VIA-VILI similar to colposcopy low-grade threshold representa chance to reduce cervical cancer mortality through see-and-treat approaches among women with limited access to health care. (scielo.org.co)
  • Colposcopy is an office gynecological procedure used for cervical evaluation in patients with abnormal cervical cytology. (bioportfolio.com)
  • There were 168 cases of cervical high-grade cervical squamous intraepithelial lesions, of these, 31 were treated with cold-knife conization, 104 loop electrosurgical excision procedure, 9 hysterectomy and 24 conservative treatment (i.e., clinical and cytological follow-up or cervical electrocoagulation). (scielo.br)
  • It is considered an important tool for early detection of cases of cervical ca. (bioportfolio.com)
  • A detailed guide to the many factors that need to be considered when planning and managing a screening programme for the early detection of cervical cancer. (who.int)
  • Recent recommendations for cervical cancer primary prevention highlight HPV vaccination, and secondary prevention through screening. (gwu.edu)
  • Meeting cervical cancer screening and HPV vaccination goals will require significant investments in the health care workforce, improving health care worker density in poor and rural areas, and improved training of the existing workforce. (gwu.edu)
  • The storytelling narrative episodes in the application will feature video clips of the multiple stories of women living with HIV infection, HIV support group leaders, community leaders, and health care professionals and a Learn More video of physician discussing cervical cancer. (nih.gov)
  • Persistent infection with high-risk Human Papilloma Virus is a necessary cause for the appearance of cervical cancer. (scielo.org.co)
  • However, the mode of action in dual infection in cervical oncogenesis needs further investigation. (nih.gov)
  • HPV infection with the most common neoplasms of the conjunctiva [1]. (deepdyve.com)
  • Infection with some types of HPV is the greatest risk factor for cervical cancer, followed by smoking. (wikipedia.org)
  • Infection with HPV is generally believed to be required for cervical cancer to occur. (wikipedia.org)
  • Incidental Gynecologic Tract Neoplasms in Women Undergoing Anterior Pelvic Exenteration for Urothelial Carcinoma. (bireme.br)
  • This study is aimed to assess the prevalence of unanticipated gynecologic neoplasms in anterior pelvic exenteration specimens. (bireme.br)
  • Coexisting neoplasms of the gynecologic tract are occasionally identified, therefore careful evaluation of these organs is necessary. (bireme.br)
  • Cervical cancer screening using the Pap test or acetic acid can identify precancerous changes, which when treated, can prevent the development of cancer. (wikipedia.org)
  • Also, moderate pain during sexual intercourse and vaginal discharge are symptoms of cervical cancer. (wikipedia.org)
  • Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients. (amedeo.com)
  • Association of HSPA1A gene single nucleotide polymorphisms with the development of cervical cancer among ethnic Han Chinese from Yunnan]. (amedeo.com)
  • Smoking has also been linked to the development of cervical cancer. (wikipedia.org)
  • See, Test & Treat: A 5-Year Experience of Pathologists Driving Cervical and Breast Cancer Screening to Underserved and Underinsured Populations. (umassmed.edu)
  • In Mexico, cervical uterine cancer (CUCA) and breast cancer (BC) are the main causes of death from cancer in women. (scielosp.org)
  • In 1994 it was discovered that women who inherit a mutated BRCA1 gene have an almost 85% chance of developing breast cancer and an increased chance of developing uterine cancer. (thefreedictionary.com)
  • These changes constitute the precursor lesions of cervical cancer. (clinicaltrials.gov)
  • This review describes the current understanding of MMP-2 and MMP-9 expression and activity in pre-cancer and cancer lesions of cervical uterine, which may open new strategies for diagnostic and therapeutic interventions. (spandidos-publications.com)
  • Uterine Neoplasms Clinical Practice Guidelines in Oncology NCCN Categories of Evidence and Consensus Category 1: The recommendation is based on high-level evidence (e.g., randomized controlled trials) and there is uniform NCCN consensus. (jnccn.org)
  • I. Determine whether MRI guidance during internal radiation therapy applicator placement improves the high-risk clinical target volume (HR-CTV) D90 (dose to 90% of the high-risk clinical target volume) rate compared to conventional guidance, with ultrasound and freehand technique, for patients with cervical and vaginal cancer. (clinicaltrials.gov)
  • Squamous microcarcinomas of the uterine cervix represent a focus of controversy regarding a useful clinical definition. (biomedsearch.com)
  • Three (30.0%) women among those undergoing clinical and cytological follow-up and five (35.7%) among those submitted to cervical electrocoagulation had recurrent disease within three years, but the difference was not significant (p=0.5611). (scielo.br)
  • The level of miR-183-5p in different cervical cancer cell lines and clinical tissues was detected qRT-PCR assays. (medscimonit.com)
  • miR-183-5p was reduced in clinical tissues of cervical cancer and cell lines when compared to the normal subjects and normal cervical epithelial cell line, respectively. (medscimonit.com)
  • CT of clinical stage IIB cervical carcinoma. (medscape.com)
  • Mutational analysis of KRAS and its clinical implications in cervical cancer patients. (amedeo.com)
  • 1 Despite the absence of clinical trials, the relation between Pap-smear screening and reduction of cervical cancer incidence and mortality has been recognized. (scielo.org.mx)
  • This study is a phase II clinical and pharmacokinetic trial of PM00104 (Zalypsis®) in patients with advanced and/or metastatic endometrial or cervical cancer previously treated with one line of systemic chemotherapy to evaluate the antitumor activity and to determine the safety profile, the pharmacokinetic profile and the pharmacogenomic profile. (checkorphan.org)
  • Fifty eight randomly selected cases of squamous cell carcinomas (SCC) of the uterine cervix, 14 normal cervices specimens, 21 CIN-2/3 and 16 CIN-1 cases were examined for EBV and HPV infections. (nih.gov)
  • Co-carcinogenesis: Human Papillomaviruses, Coal Tar Derivatives, and Squamous Cell Cervical Cancer. (amedeo.com)
  • She had a history of cervical squamous cell carcinoma, stage IIb, which was treated 15 years previously with radiation therapy. (springermedizin.de)
  • About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. (wikipedia.org)
  • A 49-year-old woman presenting with genital bleeding was referred to our hospital and diagnosed with stage IIB cervical cancer. (hindawi.com)
  • She was diagnosed with stage IIB cervical cancer by rectal examination and was admitted to our hospital. (hindawi.com)
  • In this study of 58 cervical in situ and invasive adenocarcinomas, the diagnostic accuracy of cervical biopsies was found to be closely related to the extent and the degree of differentiation of the neoplasm. (nih.gov)
  • The presence of a desmoplastic reaction further supported the invasive nature of the neoplasm. (nih.gov)
  • However, invasive cervical cancer remains a disease of significant morbidity, and it is a major cause of cancer deaths in women worldwide, although the incidence and mortality rates of invasive cervical cancer have declined substantially (particularly in countries that have well-developed screening programs). (medscape.com)
  • Cervical cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality among women in sub-Saharan Africa. (gwu.edu)
  • To identify critical screening program factors for reducing cervical cancer mortality in Colombia. (scielo.org.mx)
  • 1,3 In Colombia, cervical cancer remains the first cause of cancer mortality and the second cause of cancer incidence among women. (scielo.org.mx)
  • similarly, for countries in the region with decreasing cervical cancer mortality (Mexico, Chile, Costa Rica, Colombia), no clear association between reported organization of screening program and reduction in mortality rates could be determined. (scielo.org.mx)
  • This study thus sought to evaluate recent cervical cancer mortality trends in Spain. (biomedcentral.com)
  • The positive influence of opportunistic screening is not strong enough to further reduce cervical cancer mortality rates in the country. (biomedcentral.com)
  • The study of cervical cancer mortality has always been hampered by the widely known phenomenon of under-registration in the certification of this cause of death [ 8 ]. (biomedcentral.com)
  • This gradual improvement in data quality, which has not been taken into account in the most recent study on cervical cancer mortality in Spain [ 9 ], directly affects and distorts time trends. (biomedcentral.com)
  • Cervical adenocarcinoma in situ: the predictive value of conization margin status. (biomedsearch.com)
  • OBJECTIVE: We evaluated the impact of conization margin status on outcomes of patients diagnosed with cervical adenocarcinoma in situ. (biomedsearch.com)