Histamine H1 Antagonists, Non-Sedating
Histamine H1 Antagonists
National Institutes of Health (U.S.)
Repeated hand urticaria due to contact with fishfood. (1/402)BACKGROUND: The etiology of urticaria is often difficult to determine. However, in case of repeated circumstance-connected urticaria, the reason may be easily clarifyable. CASE: A 51-year-old healthy woman repeatedly experienced occupational hand urticaria when handling fish food. An unexpected reason for the urticaria was found in that the fishfood contained histamine as a "contaminant". CONCLUSIONS: In fishfood batches, biological degradation can produce histamine and possibly other toxic substances that can lead to occupational health problems. (+info)
Genetic linkage of the Muckle-Wells syndrome to chromosome 1q44. (2/402)The Muckle-Wells syndrome (MWS) is a hereditary inflammatory disorder characterized by acute febrile inflammatory episodes comprising abdominal pain, arthritis, and urticaria. Progressive nerve deafness develops subsequently, and, after several years, the disease is complicated by multiorgan AA-type amyloidosis (i.e., amyloidosis derived from the inflammatory serum amyloid-associated protein) (MIM 191900) with renal involvement and end-stage renal failure. The mode of inheritance is autosomal dominant, but some sporadic cases have also been described. No specific laboratory findings have been reported. The genetic basis of MWS is unknown. Using a genomewide search strategy in three families, we identified the locus responsible for MWS, at chromosome 1q44. Our results indicate that the gene is located within a 13.9-cM region between markers D1S2811 and D1S2882, with a maximum two-point LOD score of 4. 66 (recombination fraction.00) at D1S2836 when full penetrance is assumed. Further identification of the specific gene that is responsible for MWS will therefore provide the first biological element for characterizing MWS, other than doing so on the basis of its variable clinical expression. (+info)
Acquired lipoprotein lipase deficiency associated with chronic urticaria. A new etiology for type I hyperlipoproteinemia. (3/402)Type I hyperlipoproteinemia (type I HLP) is a rare disorder of lipid metabolism characterized by fasting chylomicronemia and reduced postheparin plasma lipoprotein lipase (LPL) activity. Most cases of type I HLP are due to genetic defects in the LPL gene or in its activator, the apolipoprotein CII gene. Several cases of acquired type I HLP have also been described in the course of autoimmune diseases due to the presence of circulating inhibitors of LPL. Here we report a case of type I HLP due to a transient defect of LPL activity during puberty associated with chronic idiopathic urticaria (CIU). The absence of any circulating LPL inhibitor in plasma during the disease was demonstrated. The LPL genotype showed that the patient was heterozygous for the D9N variant. This mutation, previously described, can explain only minor defects in the LPL activity. The presence of HLP just after the onset of CIU, and the elevation of the LPL activity with remission of the HLP when the patient recovered from CIU, indicate that type I HLP was caused by CIU. In summary, we report a new etiology for type I HLP - a transient decrease in LPL activity associated with CIU and with absence of circulating inhibitors. This is the first description of this association, which suggests a new mechanism for type I HLP. (+info)
Inhibition of aminopeptidase P potentiates wheal response to bradykinin in angiotensin-converting enzyme inhibitor-treated humans. (4/402)Bradykinin is a nonapeptide that contributes to the cardioprotective effects of angiotensin-converting enzyme (ACE) inhibitors. During ACE inhibition, an increased proportion of bradykinin is degraded through non-ACE pathways. Studies in animals suggest that aminopeptidase P (EC 22.214.171.124) may contribute to the metabolism of bradykinin. The purpose of the present study was to determine the contribution of aminopeptidase P to the degradation of bradykinin in humans in the presence and absence of ACE inhibition. To do this, we measured the wheal response to intradermal injection of bradykinin (0, 1, or 10 nicrog) in the presence or absence of intradermal administration of the specific aminopeptidase P inhibitor apstatin (5 or 10 microg) and oral administration of the ACE inhibitor quinapril (10 mg) in six healthy subjects. Both bradykinin (ANOVA; F = 101.18, P <.001) and apstatin alone (F = 7.01, P =.049) caused a wheal of dose-dependent size. There was no significant interaction between apstatin and bradykinin (F = 4.94, P =.175). Pretreatment with 10 mg of quinapril significantly shifted the dose-response curve for bradykinin to the left (effect of quinapril; F = 77.96, P <.001) and there was significant interaction between quinapril and bradykinin (F = 7.82, P =.041). The effect of quinapril was significantly potentiated by coinjection of 10 microg of apstatin (effect of apstatin; F = 21.60, P =.006), such that there was significant interactive effect of quinapril and apstatin (F = 20.83, P =.006) on the wheal response to bradykinin. Collectively, these data suggest that aminopeptidase P plays a minor role in the degradation of bradykinin in human skin in the absence of ACE inhibition but contributes significantly to the degradation of bradykinin in the presence of ACE inhibition. (+info)
Pharmacodynamic interaction of eltanolone and alfentanil during lower abdominal surgery in female patients. (5/402)We have studied the influence of eltanolone on intraoperative alfentanil requirements in 18 female patients undergoing lower abdominal surgery receiving target-controlled infusions of eltanolone and alfentanil. While target concentrations of eltanolone were maintained constant, target concentrations of alfentanil changed in response to the presence or absence of responses. With serum eltanolone concentrations increasing from 500 to 2000 ng ml-1, the EC50 of alfentanil for suppression of responses to surgical stimulation decreased from 233 to 9 ng ml-1. The findings suggest that the interaction between eltanolone and alfentanil is synergistic. (+info)
Additive-induced urticaria: experience with monosodium glutamate (MSG). (6/402)In patients with chronic urticaria, the incidence of reactions to any additives, including monosodium glutamate (MSG), is unknown. Although many studies have investigated the association of additives and urticaria, most have been poorly designed. This study sought to determine the prevalence of reactions to additives, including MSG, in patients with chronic urticaria using a rigorous protocol. We studied 65 subjects (44 women, 21 men; ages 14-67). All had urticaria for >6 wk without discernible etiology. Subjects with active urticaria were studied while they were taking the lowest effective dose of antihistamine. Screening challenges to the 11 additives most commonly associated with exacerbations of chronic idiopathic urticaria were performed in a single-blind fashion. The dose of MSG given was 2500 mg. Skin scores were obtained to determine a positive reaction in an objective manner. Subjects with a positive screening challenge were rechallenged (at least 2 wk later) with a double-blind, placebo-controlled protocol as in-patients in our General Clinical Research Center. Two subjects had positive single-blind, placebo-controlled challenges, but neither had a positive double-blind, placebo-controlled challenge. We conclude, with 95% confidence, that MSG is an unusual (<3% at most) exacerbant of chronic idiopathic urticaria. (+info)
Identification of a locus on chromosome 1q44 for familial cold urticaria. (7/402)Familial cold urticaria (FCU) is a rare autosomal dominant inflammatory disorder characterized by intermittent episodes of rash with fever, arthralgias, conjunctivitis, and leukocytosis. These symptoms develop after generalized exposure to cold. Some individuals with FCU also develop late-onset reactive renal amyloidosis, which is consistent with Muckle-Wells syndrome. By analyzing individuals with FCU from five families, we identified linkage to chromosome 1q44. Two-point linkage analysis revealed a maximum LOD score (Zmax) of 8.13 (recombination fraction 0) for marker D1S2836; multipoint linkage analysis identified a Zmax of 10. 92 in the same region; and haplotype analysis defined a 10.5-cM region between markers D1S423 and D1S2682. Muckle-Wells syndrome was recently linked to chromosome 1q44, which suggests that the two disorders may be linked to the same locus. (+info)
Medical surveillance of allergy in laboratory animal handlers. (8/402)Allergic disease is a serious occupational health concern for individuals who have contact with laboratory animals. The principal respiratory symptoms include allergic rhinitis, conjunctivitis, and asthma. Urticaria (" hives") is the most common skin manifestation. The overall prevalence of allergic disease among laboratory animal handlers is about 23%, and respiratory allergy is much more common than skin allergy. Various studies have found annual incidence rates ranging from 2% to 12%. Prevention of animal allergy depends on control of allergenic material in the work environment. Personal protective equipment such as air filtering respirators should be used in addition to the other exposure control technologies where conditions require. Pre-placement evaluation and periodic medical surveillance of workers are important pieces of the overall occupational health program. The emphasis of these medical evaluations should be on counseling and early disease detection. The article gives recommendations for the content of the medical evaluations. (+info)
The symptoms of urticaria can vary in severity and may include:
* Appearance of hives or wheals on the skin, often in a patterned or widespread distribution
* Itching or burning sensations on the skin
* Redness, swelling, or warmth of the affected area
* In some cases, angioedema (swelling of the deeper layers of skin)
Urticaria can be caused by a variety of factors, including:
* Allergies to foods, drugs, or insect bites
* Exposure to environmental allergens such as pollen, dust mites, or animal dander
* Infections, such as colds or flu
* Physical stimuli, such as pressure, cold, or heat
* Certain medications, such as antibiotics or nonsteroidal anti-inflammatory drugs (NSAIDs)
* Hormonal changes, such as those that occur during pregnancy or menstruation
Urticaria can be diagnosed through a physical examination and medical history, and may require further testing to determine the underlying cause. Treatment for urticaria typically involves avoiding triggers, using antihistamines or corticosteroids to reduce symptoms, and addressing any underlying conditions that may be contributing to the condition. In severe cases, hospitalization may be necessary to manage the symptoms and prevent complications.
Urticaria Pigmentosa typically presents in infancy or early childhood and can progress to more severe symptoms over time. In addition to the skin and eye changes, individuals with this condition may also experience joint pain, fatigue, and respiratory problems. There is currently no cure for Urticaria Pigmentosa, but various treatments are available to manage its symptoms and prevent complications.
The diagnosis of Urticaria Pigmentosa is based on a combination of clinical evaluation, family history, and genetic testing. Treatment options may include medications such as antihistamines, corticosteroids, and immunosuppressants, as well as phototherapy and laser therapy to manage skin lesions. In severe cases, bone marrow transplantation may be considered.
Prognosis for individuals with Urticaria Pigmentosa varies depending on the severity of the condition and the presence of any additional health problems. While some people with mild forms of the condition may experience few or no complications, others may develop more severe symptoms and require ongoing medical care throughout their lives. Regular monitoring and management by a healthcare team is essential to ensure the best possible outcome for individuals with Urticaria Pigmentosa.
Acute angioedema is usually triggered by an allergic reaction or exposure to certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), blood pressure medications, or antibiotics. It can also be caused by infections, insect bites, and other environmental triggers.
Chronic angioedema, on the other hand, is a more persistent form of the condition that can last for weeks, months, or even years. It is often associated with conditions such as hereditary angioedema (HAE), which is caused by a genetic defect that affects the production of a protein called C1 esterase inhibitor.
The symptoms of angioedema can vary depending on the location and severity of the swelling, but they typically include:
* Swelling in the face, hands, feet, or other parts of the body
* Redness and warmth of the affected area
* Pain or discomfort
* Difficulty breathing or swallowing (in severe cases)
There is no cure for angioedema, but there are several treatments available to help manage the symptoms. These may include:
* Antihistamines or corticosteroids to reduce inflammation and relieve itching
* Ice packs or cool compresses to reduce swelling
* Compression stockings or bandages to prevent fluid buildup
* Pain relief medications, such as ibuprofen or acetaminophen, to manage discomfort
In severe cases of angioedema, hospitalization may be necessary to provide more intensive treatment and monitoring. In some cases, injectable medications such as epinephrine or corticosteroids may be administered to help reduce swelling and prevent complications.
Overall, angioedema is a serious condition that requires prompt medical attention to manage symptoms and prevent complications. If you suspect you or someone else may have angioedema, it is important to seek medical help right away.
There are several different types of drug hypersensitivity reactions, including:
1. Maculopapular exanthema (MPE): This is a type of allergic reaction that causes a red, itchy rash to appear on the skin. It can be caused by a variety of medications, including antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs).
2. Exfoliative dermatitis: This is a more severe form of MPE that can cause widespread scaling and peeling of the skin. It is often associated with reactions to antibiotics and other medications.
3. Stevens-Johnson syndrome (SJS): This is a rare but potentially life-threatening condition that can be caused by certain medications, including antibiotics and NSAIDs. SJS can cause blisters to form on the skin and mucous membranes, as well as fever and fatigue.
4. Toxic epidermal necrolysis (TEN): This is a severe and potentially life-threatening condition that can be caused by certain medications, including antibiotics and NSAIDs. TEN can cause widespread peeling of the skin, as well as fever and fatigue.
5. Anaphylaxis: This is a severe allergic reaction that can be caused by a variety of medications, including antibiotics and NSAIDs. It can cause symptoms such as hives, itching, swelling, and difficulty breathing.
Drug hypersensitivity reactions can be diagnosed through a combination of physical examination, medical history, and laboratory tests. Treatment typically involves discontinuing the medication that is causing the reaction, as well as providing supportive care to manage symptoms such as fever, itching, and pain. In severe cases, hospitalization may be necessary to monitor and treat the reaction.
Prevention of drug hypersensitivity reactions can be challenging, but there are several strategies that can help reduce the risk. These include:
1. Gradual dose escalation: When starting a new medication, it is important to gradually increase the dose over time to allow the body to adjust.
2. Monitoring for signs of a reaction: Patients should be monitored closely for signs of a reaction, such as hives, itching, or difficulty breathing.
3. Avoiding certain medications: In some cases, it may be necessary to avoid certain medications that are known to cause hypersensitivity reactions.
4. Skin testing: Skin testing can be used to determine whether a patient is allergic to a particular medication before starting treatment.
5. Desensitization: In some cases, desensitization therapy may be used to gradually expose the patient to the medication that is causing the reaction, with the goal of reducing the risk of an adverse event.
The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the World Health Organization (WHO). In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.
In this article, we will explore the definition and impact of chronic diseases, as well as strategies for managing and living with them. We will also discuss the importance of early detection and prevention, as well as the role of healthcare providers in addressing the needs of individuals with chronic diseases.
What is a Chronic Disease?
A chronic disease is a condition that lasts for an extended period of time, often affecting daily life and activities. Unlike acute diseases, which have a specific beginning and end, chronic diseases are long-term and persistent. Examples of chronic diseases include:
2. Heart disease
6. Chronic obstructive pulmonary disease (COPD)
7. Chronic kidney disease (CKD)
Impact of Chronic Diseases
The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the WHO. In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.
Chronic diseases can also have a significant impact on an individual's quality of life, limiting their ability to participate in activities they enjoy and affecting their relationships with family and friends. Moreover, the financial burden of chronic diseases can lead to poverty and reduce economic productivity, thus having a broader societal impact.
Addressing Chronic Diseases
Given the significant burden of chronic diseases, it is essential that we address them effectively. This requires a multi-faceted approach that includes:
1. Lifestyle modifications: Encouraging healthy behaviors such as regular physical activity, a balanced diet, and smoking cessation can help prevent and manage chronic diseases.
2. Early detection and diagnosis: Identifying risk factors and detecting diseases early can help prevent or delay their progression.
3. Medication management: Effective medication management is crucial for controlling symptoms and slowing disease progression.
4. Multi-disciplinary care: Collaboration between healthcare providers, patients, and families is essential for managing chronic diseases.
5. Health promotion and disease prevention: Educating individuals about the risks of chronic diseases and promoting healthy behaviors can help prevent their onset.
6. Addressing social determinants of health: Social determinants such as poverty, education, and employment can have a significant impact on health outcomes. Addressing these factors is essential for reducing health disparities and improving overall health.
7. Investing in healthcare infrastructure: Investing in healthcare infrastructure, technology, and research is necessary to improve disease detection, diagnosis, and treatment.
8. Encouraging policy change: Policy changes can help create supportive environments for healthy behaviors and reduce the burden of chronic diseases.
9. Increasing public awareness: Raising public awareness about the risks and consequences of chronic diseases can help individuals make informed decisions about their health.
10. Providing support for caregivers: Chronic diseases can have a significant impact on family members and caregivers, so providing them with support is essential for improving overall health outcomes.
Chronic diseases are a major public health burden that affect millions of people worldwide. Addressing these diseases requires a multi-faceted approach that includes lifestyle changes, addressing social determinants of health, investing in healthcare infrastructure, encouraging policy change, increasing public awareness, and providing support for caregivers. By taking a comprehensive approach to chronic disease prevention and management, we can improve the health and well-being of individuals and communities worldwide.
Symptoms of anaphylaxis include:
1. Swelling of the face, lips, tongue, and throat
2. Difficulty breathing or swallowing
3. Abdominal cramps
4. Nausea and vomiting
5. Rapid heartbeat
6. Feeling of impending doom or loss of consciousness
Anaphylaxis is diagnosed based on a combination of symptoms, medical history, and physical examination. Treatment for anaphylaxis typically involves administering epinephrine (adrenaline) via an auto-injector, such as an EpiPen or Auvi-Q. Additional treatments may include antihistamines, corticosteroids, and oxygen therapy.
Prevention of anaphylaxis involves avoiding known allergens and being prepared to treat a reaction if it occurs. If you have a history of anaphylaxis, it is important to carry an EpiPen or other emergency medication with you at all times. Wearing a medical alert bracelet or necklace can also help to notify others of your allergy and the need for emergency treatment.
In severe cases, anaphylaxis can lead to unconsciousness, seizures, and even death. Prompt treatment is essential to prevent these complications and ensure a full recovery.
There are several types of food hypersensitivity, including:
1. Food Allergy: An immune system reaction to a specific food that can cause symptoms ranging from mild hives to life-threatening anaphylaxis. Common food allergies include reactions to peanuts, tree nuts, fish, shellfish, milk, eggs, wheat, and soy.
2. Non-Allergic Food Hypersensitivity: Also known as non-IgE-mediated food hypersensitivity, this type of reaction does not involve the immune system. Symptoms can include bloating, abdominal pain, diarrhea, and headaches. Common culprits include gluten, dairy, and high-FODMAP foods.
3. Food Intolerance: A condition where the body cannot properly digest or process a specific food. Symptoms can include bloating, abdominal pain, diarrhea, and gas. Common food intolerances include lactose intolerance, fructose malabsorption, and celiac disease.
4. Food Aversion: An emotional response to a specific food that can cause avoidance or dislike of the food. This is not an allergic or physiological reaction but rather a psychological one.
The diagnosis of food hypersensitivity typically involves a thorough medical history, physical examination, and diagnostic tests such as skin prick testing or blood tests. Treatment options for food hypersensitivity depend on the type and severity of the reaction and may include avoidance of the offending food, medication, or immunotherapy.
Anisakiasis is most commonly seen in people who consume raw or undercooked fish that have been infected with the parasite. This can include sashimi, ceviche, and other dishes that involve raw fish. The parasites can also be found in fish sauces and other processed seafood products.
The symptoms of anisakiasis typically occur within a few hours to a few days after consuming the infected fish, and can include:
* Abdominal pain
In severe cases, anisakiasis can lead to complications such as intestinal obstruction or perforation, which can be life-threatening.
The diagnosis of anisakiasis is typically made based on a combination of symptoms and medical history, as well as the results of imaging tests such as X-rays or CT scans. Treatment usually involves supportive care, such as fluid replacement and antibiotics to prevent infection, as well as anti-inflammatory medications to reduce inflammation. In severe cases, surgery may be necessary to remove any blockages or perforations.
Prevention of anisakiasis involves avoiding the consumption of raw or undercooked fish, particularly from areas where the parasite is common. It is also important to handle and store fish properly to prevent contamination. Additionally, freezing fish to a temperature of at least -4°F (-20°C) for at least 7 days can kill any parasites that may be present.
Delayed pressure urticaria
Urticaria-like follicular mucinosis
Localized heat contact urticaria
Peripherally selective drug
Erythema toxicum neonatorum
Cold urticaria - About the Disease - Genetic and Rare Diseases Information Center
Familial amyloid nephropathy with urticaria AND deafness - NIH Genetic Testing Registry (GTR) - NCBI
Chronic Urticaria Differential Diagnoses
Urticaria pigmentosa: MedlinePlus Medical Encyclopedia
Chronic Urticaria Differential Diagnoses
Hives (Urticaria) (for Parents) - CHOC Childrens
Hives (Urticaria) & Angioedema Symptoms, Diagnosis & Treatment
The Complexity of Urticaria | Frontiers Research Topic
Is Glutamine Good For Urticaria?
Acute Urticaria Clinical Presentation: History, Physical Examination, Staging
Chronic urticaria - PubMed
Aquagenic urticaria | DermNet
Hives (urticaria) on the arm: MedlinePlus Medical Encyclopedia Image
US breakthrough designation for ligelizumab in chronic spontaneous urticaria - PharmaTimes
Physical Urticaria - Healthy Skin Care
PRIME PubMed | Serum interleukin-18 in patients with chronic ordinary urticaria: association with disease activity
Novartis' Xolair® recommended in new global chronic urticaria guideline
Skin Challenge: Urticaria | Associated Skin Care Professionals
Do steroids help children with acute urticaria? | Archives of Disease in Childhood
Mechanism of mast cell activation in patients with vibratory urticaria | NIH Research Festival
Subjects: Urticaria - Digital Collections - National Library of Medicine Search Results
Anesthesia in a Patient with Urticaria Pigmentosa (Cutaneous Mastocytosis) | Medicalalgorithms.com
Hives (Urticaria) | MyTeleHealth
Urticaria Treatment - Toshidental
Allegra dose urticaria
Allegra dosage urticaria
- When hives occur for less than 6 weeks, we call this acute urticaria. (aaaai.org)
- When hives last longer than 6 weeks, we change the name to chronic urticaria. (aaaai.org)
- Chronic urticaria (hives over 6 weeks) is not dangerous. (aaaai.org)
- Urticaria is termed as a dermatological condition and used in reference to chronic hives . (home-remedies-for-you.com)
- Hives or urticaria is an allergic reaction in the skin and a La Jolla, California based research concluded with 95% confidence that MSG (mono sodium glutamate) exacerbated chronic idiopathic urticaria. (home-remedies-for-you.com)
- Tiny pinpoint hives are characteristic of cholinergic urticaria. (medscape.com)
- Chronic urticaria (CU) is a severe disease that is characterized by the reoccurrence of persistent hives and/or sometimes painful deeper swelling of the skin for 6 weeks or more. (worldpharmanews.com)
- Urticaria, or hives, often appears as red, raised, and itchy blotches of skin that might look like bug bites. (ascpskincare.com)
- Often lasting six months or less, acute Hepatitis C can cause red, itchy rash aka urticaria (hives) which often occurs when the body is trying to fight off the infection. (ascpskincare.com)
- Upon dermal vibration, patients with vibratory urticaria (VU) experience localized hives and increased histamine levels in serum. (nih.gov)
- URTICARIA also known as HIVES.It is a skin rash with red ,rised,itchy bumps.they may also burn or sting Rash lasts for few days but do not leave a scar ,the condition frequently recurs and lasts more than 6 weeks. (starhomeopathy.com)
- Hives carried by stroking the skin are due to a benign condition called DERMATOGRAPHIC URTICARIA. (starhomeopathy.com)
- Hives - also known as urticaria - are raised, red, itchy welts (wheals, or swellings) of various sizes that seem to appear and disappear on your skin. (mytelehealth.info)
- Background:Urticaria or hives, that occur everywhere on the body. (who.int)
- Bansal AS, Hayman GR. Graves disease associated with chronic idiopathic urticaria: 2 case reports. (medscape.com)
- Xolair is approved for the treatment of CSU in over 80 countries including the European Union and for chronic idiopathic urticaria (CIU), as it is known in the US and Canada. (worldpharmanews.com)
- Nevertheless, 39% of the second-generation antihistamines available in Poland (66 preparations of cetirizine, emedastine, levocetirizine, loratadine or fexofenadine) were registered only for the official indication "chronic idiopathic urticaria" - a historical term that is inconsistent with the current state of medical knowledge. (diaseries.eu)
- Increased cis-to-trans urocanic acid ratio in the skin of chronic spontaneous urticaria patients. (medscape.com)
- Role of small intestinal bacterial overgrowth and Helicobacter pylori infection in chronic spontaneous urticaria: a prospective analysis. (medscape.com)
- Thus, we presently know that a subgroup of Chronic Spontaneous Urticaria (CSU) patients has a frank IgG-mediated auto-immune disease leading to histamine release from mast cells and basophils via the binding of autoantibodies to the high-affinity IgE receptors, or to cell surface-bound IgE. (frontiersin.org)
- The US Food and Drug Administration (FDA) has granted Novartis' ligelizumab a breakthrough therapy designation for the treatment of patients with chronic spontaneous urticaria (CSU) who have an inadequate response to H1-antihistamine treatment. (pharmatimes.com)
- Chronic spontaneous urticaria is a debilitating disease that may significantly impact a patient's life. (pharmatimes.com)
- A new global guideline on chronic urticaria (CU) recommends Xolair® (omalizumab), indicated as add-on therapy for the treatment of chronic spontaneous urticaria (CSU), for patients who are not responding to antihistamines,. (worldpharmanews.com)
- Other key brands include Xolair® (omalizumab) in chronic spontaneous urticaria (CSU), Zortress®/Certican® (everolimus) and Myfortic® (mycophenolic acid) in transplant and Ilaris® (canakinumab), approved to treat several rare diseases including some Periodic Fever Syndromes. (worldpharmanews.com)
- Laboratory tests and identified diagnoses in patients with physical and chronic urticaria and angioedema: A systematic review. (medscape.com)
- Chronic urticaria and angioedema associated with thyroid autoimmunity: review and therapeutic implications. (medscape.com)
- Urticaria, angioedema, and pruritus. (medlineplus.gov)
- As many as 50% of children who have urticaria exhibit angioedema with swelling of the hands and feet. (medscape.com)
- Urticaria and angioedema may be produced by immunologic or nonimmunologic means. (nih.gov)
- Antihistamines in urticaria and angioedema. (nih.gov)
- 2.There is a condition called as angioedema which occurs in urticaria. (yamunapharmacy.com)
- The diagnosis and management of acute and chronic urticaria: 2014 update. (medscape.com)
- The goals are to provide state-of the art information (either investigational and clinical research or review articles) that cover the following fields of the topic: acute urticaria, pathogenic mechanisms of CU's, burden of CSU and inducible CUs, quality of life in CU patients, new treatments, biomarkers, therapeutic approaches, and unmet needs. (frontiersin.org)
- Rarely, acute urticaria can last 3-6 weeks. (medscape.com)
- Acute urticaria associated with dermatographism. (medscape.com)
- Do steroids help children with acute urticaria? (bmj.com)
- There are no studies specifically aimed at children with acute urticaria. (bmj.com)
- Oral prednisolone added to antihistamines may result in decreased itch and more rapid rash resolution in acute urticaria. (bmj.com)
- Outpatient management of acute urticaria: the role of prednisone. (bmj.com)
- Acute urticaria: clinical aspects and therapeutic responsiveness. (bmj.com)
- Aquagenic urticaria is a rare variant of chronic inducible urticaria induced by contact with water. (dermnetnz.org)
- Who gets aquagenic urticaria? (dermnetnz.org)
- Less than 100 cases of aquagenic urticaria have been reported in the medical literature. (dermnetnz.org)
- What causes aquagenic urticaria? (dermnetnz.org)
- The exact pathogenesis of aquagenic urticaria is not yet known, but a number of hypotheses have been proposed. (dermnetnz.org)
- Aquagenic urticaria appears whatever the water temperature, saltiness, or pH , and is not dependent on psychogenic factors. (dermnetnz.org)
- What are the clinical features of aquagenic urticaria? (dermnetnz.org)
- What are the complications of aquagenic urticaria? (dermnetnz.org)
- Patients with aquagenic urticaria may suffer from psychological stress due to a fear of water. (dermnetnz.org)
- How is aquagenic urticaria diagnosed? (dermnetnz.org)
- A clinical history of urticaria in response to water exposure is suspicious of aquagenic urticaria, but the diagnosis should be confirmed by a positive water provocation test and exclusion of other types of chronic inducible urticaria . (dermnetnz.org)
- What is the differential diagnosis for aquagenic urticaria? (dermnetnz.org)
Forms of urticaria1
- Your provider may prescribe other kinds of medicine to treat symptoms of severe and unusual forms of urticaria pigmentosa. (medlineplus.gov)
Symptoms of urticaria1
- Contact your provider if you notice symptoms of urticaria pigmentosa. (medlineplus.gov)
- Itchy rashes and pain in the areas like eyes, throat, cheeks, lips, hands, neck genitals then you may be the sufferer of "Urticaria" which is a very common skin disease. (yamunapharmacy.com)
- Pruritus (itching) and rash are the primary manifestations of urticaria, and permanent hyperpigmentation or hypopigmentation is rare. (medscape.com)
- Rashes are relatively common in people with hepatitis C. A common skin rash related to hepatitis C is called urticaria. (ascpskincare.com)
- Urticaria pigmentosa is a skin disease that produces patches of darker skin and very bad itching . (medlineplus.gov)
- Urticaria pigmentosa occurs when there are too many inflammatory cells (mast cells) in the skin. (medlineplus.gov)
- Urticaria pigmentosa is most common in children. (medlineplus.gov)
- Urticaria pigmentosa goes away by puberty in about one half of affected children. (medlineplus.gov)
- Insect stings may also cause a bad allergic reaction in people with urticaria pigmentosa. (medlineplus.gov)
- A patient with urticaria pigmentosa can undergo anesthesia and surgery safely, provided certain precautions are taken. (medicalalgorithms.com)
- Urticaria symptoms may often signify underlying medical conditions and call for a thorough diagnosis. (home-remedies-for-you.com)
- Therapeutic alternatives for chronic urticaria: an evidence-based review, part 1. (medscape.com)
- Furthermore, therapeutic approaches to Chronic Urticaria (CU) represent a challenging field as no curative treatment exists for CU, and all currently recommended treatment options are intended to control and prevent the symptoms of CU. The ultimate goal remains the development of treatments that can prevent CU, alter its course, and cure patients. (frontiersin.org)
- Among therapeutical products authorized for the use in Poland, yet lacking the official indication for the treatment of urticaria, there were 170 preparations containing one of 6 active substances (cyclosporin A, doxepin, montelukast, omalizumab, prednisone, zafirlukast), whose therapeutic efficacy in at least one type of urticaria has been confirmed in high- or moderate-quality clinical studies. (diaseries.eu)
- Lesions of urticaria can be polymorphic and vary from several millimeters to large, continuous edematous plaques that have smooth surfaces with polycyclic curved borders. (medscape.com)
- Is the urticaria associated with any substances that are inhaled or come in contact with the skin (which may occur in an occupational setting)? (medscape.com)
- In the case of chronic urticaria, people are more prone to immune system disorders like systemic lupus erythematous, thyroid disease, rheumatoid arthritis and celiac diseases. (yamunapharmacy.com)
- Urticaria is characterized by transient pruritic wheals or erythematous patches on the skin . (bvsalud.org)
- You may also be prescribed oral anti histamines since urticaria may be an allergic reaction in some people. (home-remedies-for-you.com)
- For the treatment of urticaria in children below 1 year of age, none of the second-generation antihistamines was authorized for use, and only five oral preparations of first-generation antihistamines containing three active substances - dimetinden, hydroxyzine and ketotifen, whose safety profile was questioned by experts. (diaseries.eu)
- Welcome to the official website of the 6th Consensus Conference on the Update and Revision of the international EAACI/GA²LEN/EuroGuiDerm/APAAACI Guideline for Urticaria! (urticariaguideline.org)
Patients with chronic2
- Successful treatment of chronic urticaria with leukotriene antagonists. (medscape.com)
- Treatment of urticaria. (nih.gov)
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- The aim of this study was to analyze the concordance between up-to-date recommendations of Polish and international expert bodies regarding the treatment of urticaria, the Summaries of Product Characteristics in force in Poland, and the scientific evidence for the effectiveness of the recommended or registered drugs. (diaseries.eu)
- The analysis was carried out from 2012 to 2014, and included 10 recent (i.e. published from the year 2000) Polish and international guidelines of expert bodies on the treatment of urticaria. (diaseries.eu)
- Among products recommended by experts and licensed for the treatment of urticaria in Poland, high or moderate evidence of the efficacy was available for 7 active substances (bilastine, cetirizine, desloratadine, fexofenadine, loratadine, levocetirizine, rupatadine). (diaseries.eu)
- On the other hand, 10 topical preparations of the first-generation antihistamine dimetinden were licensed for the treatment of urticaria, in spite of the fact that such local treatment was not recommended by expert bodies, moreover, there was no published evidence for its efficacy. (diaseries.eu)
- Conclusion:Our study has concluded that Homoeopathic medicine has shown the efficacy in treatment of Urticaria. (who.int)
- BSACI guidelines for the management of chronic urticaria and angio-oedema. (medscape.com)
- If you are already suffering from urticaria symptoms, the condition would worsen due to exposure to harsh sunlight, extreme heat or cold, pressure and so on. (home-remedies-for-you.com)
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- The increased IL-18 levels in the ASST-positive patients with most active chronic urticaria may reflect stronger immune system activation and possibly an involvement of IL-18 as a direct histamine-releasing factor. (unboundmedicine.com)
- Helicobacter pylori infection and chronic urticaria. (medscape.com)
Group of diseases1
- Urticaria represents a highly-heterogenous group of diseases that is rather common. (frontiersin.org)
- Objectives:To study efficacy of Homoeopathic medicine in case of Urticaria.Material And Methods:Study of Urticaria cases with efficacy of Homoeopathic medicines through case study after defining, analyzing then further testing data for accuracy. (who.int)
- Urticaria may lead to some serious health complications like difficulty in breathing or allergic reactions to heart and lungs. (yamunapharmacy.com)