Urinary Bladder
Uroplakin II
Uroplakin III
Carcinoma, Transitional Cell
Cystitis
Uroplakin Ib
Urinary Tract
Ureter
Cystitis, Interstitial
Uroplakin Ia
Urinary Bladder, Overactive
Cryoultramicrotomy
Administration, Intravesical
Purinergic P2Y Receptor Agonists
Urethra
Epithelium
Tetraspanins
A large superfamily of cell surface membrane proteins characterized by their four transmembrane domains. They play a role in a variety of processes such as cellular adhesion and motility. They may be involved in the organization of cell surface MEMBRANE MICRODOMAINS that regulate the activation of LEUKOCYTES.
Keratins, Type I
Muscle, Smooth
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
Lewis Blood-Group System
A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.
Hyperplasia
Uropathogenic Escherichia coli
Microscopy, Electron, Scanning
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Keratin-13
Urine
Mucous Membrane
An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.
Immunohistochemistry
Keratin-20
Urinary Bladder, Neurogenic
Urinary Bladder Calculi
Papilloma
Muscarinic Antagonists
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
Receptors, Purinergic P2X3
A purinergic P2X neurotransmitter receptor involved in sensory signaling of TASTE PERCEPTION, chemoreception, visceral distension, and NEUROPATHIC PAIN. The receptor comprises three P2X3 subunits. The P2X3 subunits are also associated with P2X2 RECEPTOR subunits in a heterotrimeric receptor variant.
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Antineoplastic Combined Chemotherapy Protocols
Carcinoma
Biological Science Disciplines
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Directories as Topic
Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer. (1/920)
The evolution of alterations on chromosome 9, including the putative tumor suppressor genes mapped to the 9p21-22 region (the MTS genes), was studied in relation to the progression of human urinary bladder neoplasia by using whole organ superimposed histologic and genetic mapping in cystectomy specimens and was verified in urinary bladder tumors of various pathogenetic subsets with longterm follow-up. The applicability of chromosome 9 allelic losses as non-invasive markers of urothelial neoplasia was tested on voided urine and/or bladder washings of patients with urinary bladder cancer. Although sequential multiple hits in the MTS locus were documented in the development of intraurothelial precursor lesions, the MTS genes do not seem to represent a major target for p21-23 deletions in bladder cancer. Two additional tumor suppressor genes involved in bladder neoplasia located distally and proximally to the MTS locus within p22-23 and p11-13 regions respectively were identified. Several distinct putative tumor suppressor gene loci within the q12-13, q21-22, and q34 regions were identified on the q arm. In particular, the pericentromeric q12-13 area may contain the critical tumor suppressor gene or genes for the development of early urothelial neoplasia. Allelic losses of chromosome 9 were associated with expansion of the abnormal urothelial clone which frequently involved large areas of urinary bladder mucosa. These losses could be found in a high proportion of urothelial tumors and in voided urine or bladder washing samples of nearly all patients with urinary bladder carcinoma. (+info)Molecular basis for the enterocyte tropism exhibited by Salmonella typhimurium type 1 fimbriae. (2/920)
Salmonella typhimurium exhibits a distinct tropism for mouse enterocytes that is linked to their expression of type 1 fimbriae. The distinct binding traits of Salmonella type 1 fimbriae is also reflected in their binding to selected mannosylated proteins and in their ability to promote secondary bacterial aggregation on enterocyte surfaces. The determinant of binding in Salmonella type 1 fimbriae is a 35-kDa structurally distinct fimbrial subunit, FimHS, because inactivation of fimHS abolished binding activity in the resulting mutant without any apparent effect on fimbrial expression. Surprisingly, when expressed in the absence of other fimbrial components and as a translational fusion protein with MalE, FimHS failed to demonstrate any specific binding tropism and bound equally to all cells and mannosylated proteins tested. To determine if the binding specificity of Salmonella type 1 fimbriae was determined by the fimbrial shaft that is intimately associated with FimHS, we replaced the amino-terminal half of FimHS with the corresponding sequence from Escherichia coli FimH (FimHE) that contains the receptor binding domain of FimHE. The resulting hybrid fimbriae bearing FimHES on a Salmonella fimbrial shaft exhibited binding traits that resembled that of Salmonella rather than E. coli fimbriae. Apparently, the quaternary constraints imposed by the fimbrial shaft on the adhesin determine the distinct binding traits of S. typhimurium type 1 fimbriae. (+info)Frequent genetic alterations in simple urothelial hyperplasias of the bladder in patients with papillary urothelial carcinoma. (3/920)
In order to understand the origin of bladder cancer, very early urothelial lesions must be investigated in addition to more advanced tumors. Tissue from 31 biopsies of 12 patients with urothelial hyperplasias and simultaneous or consecutive superficial papillary tumors were used to microdissect urothelium from 15- microm sections of biopsies. The biopsies were obtained with the recently developed highly sensitive diagnostic method of 5-aminolevulinic acid-induced fluorescence endoscopy (AFE). Besides flat and papillary urothelial neoplasms, the method of photodynamic diagnostics also detects simple urothelial hyperplasias as fluorescent positive lesions. In addition, 12 fluorescence-positive biopsies showing histologically normal urothelium were investigated. Fluorescence in situ hybridization was done using a dual color staining technique of biotinylated centromeric probes of chromosomes 9 and 17 and digoxigenin-labeled gene-specific P1 probes for chromosomes 9q22 (FACC), 9p21(p16/CDKI2), and 17p13(p53). Ten of 14 hyperplasias (70%) showed deletions of chromosome 9. In 7 out of 8 patients with genetic alterations in the hyperplasias the genetic change was also present in the papillary tumor. Six out of 12 samples of microdissected normal urothelium also showed genetic alterations on chromosome 9. Microdissection of urothelial lesions, obtained during AFE, has led to the first unequivocal documentation of genetic changes in urothelial lesions diagnosed as normal in histopathology. Thus, this technical approach is important to provide insight into the earliest molecular alterations in bladder carcinogenesis. (+info)Urinary bladder transitional cell carcinogenesis is associated with down-regulation of NF1 tumor suppressor gene in vivo and in vitro. (4/920)
The NF1 gene product (neurofibromin) is known to act as a tumor suppressor protein by inactivating ras. The best documented factors involved in urinary bladder transitional cell carcinoma (TCC) are ras proto-oncogene activation and p53 suppressor gene mutations. This is the first study reporting alterations in NF1 gene expression in TCC. We examined NF1 gene expression in a total of 29 surgical urinary bladder TCC specimens representing grades 1 to 3 and in three cell lines, RT4, 5637, and T24 (representing grades 1 to 3, respectively). Decreased NF1 gene expression was observed in 23 of 29 (83%) TCC specimens as estimated by immunohistochemistry, the decrease being more pronounced in high-grade tumors. NF1 mRNA levels were markedly lower in TCC tissue compared with adjacent non-neoplastic urothelium, as studied by in situ hybridization for grade 3 TCC. Immunohistochemistry and Western blotting demonstrated that TCC cell lines expressed NF1 protein at different levels, expression being almost undetectable in T24 (grade 3) cells. Northern blotting for cell lines demonstrated reduced NF1 mRNA levels in grade 3 TCC cells. Reverse transcription polymerase chain reaction for cell lines and selected grade 2 and grade 3 tissue samples demonstrated NF1 type II mRNA isoform predominance in all samples studied. Our results show that both NF1 mRNA and protein levels are decreased in high-grade TCC, suggesting that alterations of NF1 gene expression may be involved in bladder TCC carcinogenesis. (+info)Primary uroepithelial cultures. A model system to analyze umbrella cell barrier function. (5/920)
Despite almost 25 years of effort, the development of a highly differentiated and functionally equivalent cell culture model of uroepithelial cells has eluded investigators. We have developed a primary cell culture model of rabbit uroepithelium that consists of an underlying cell layer that interacts with a collagen substratum, an intermediate cell layer, and an upper cell layer of large (25-100 micrometer) superficial cells. When examined at the ultrastructural level, the superficial cells formed junctional complexes and had an asymmetric unit membrane, a hallmark of terminal differentiation in bladder umbrella cells. These cultured "umbrella" cells expressed uroplakins and a 27-kDa uroepithelial specific antigen that assembled into detergent-resistant asymmetric unit membrane particles. The cultures had low diffusive permeabilities for water (2.8 x 10(-4) cm/s) and urea (3.0 x 10(-7) cm/s) and high transepithelial resistance (>8000 Omega cm2) was achieved when 1 mM CaCl2 was included in the culture medium. The cell cultures expressed an amiloride-sensitive sodium transport pathway and increases in apical membrane capacitance were observed when the cultures were osmotically stretched. The described primary rabbit cell culture model mimics many of the characteristics of uroepithelium found in vivo and should serve as a useful tool to explore normal uroepithelial function as well as dysfunction as a result of disease. (+info)Proteomics and immunohistochemistry define some of the steps involved in the squamous differentiation of the bladder transitional epithelium: a novel strategy for identifying metaplastic lesions. (6/920)
Here, we present a novel strategy for dissecting some of the steps involved in the squamous differentiation of the bladder urothelium leading to squamous cell carcinomas (SCCs). First, we used proteomic technologies and databases (http://biobase.dk/cgi-bin/celis) to reveal proteins that were expressed specifically by fresh normal urothelium and three SCCs showing no urothelial components. Thereafter, antibodies against some of the differentially expressed proteins as well as a few known keratinocyte markers were used to stain serial cryostat sections (immunowalking) of biopsies obtained from bladder cystectomies of two of the SCC-bearing patients (884-1 and 864-1). Because bladder cancer is a field disease, we surmised that the urothelium of these patients may exhibit a spectrum of abnormalities ranging from early metaplastic stages to invasive disease. Immunohistochemical analysis revealed three types of non-keratinizing metaplastic lesions (types 1-3) that did not express keratins 7, 8, 18, and 20 (expressed by normal urothelium) and could be distinguished based on their staining with keratin 19 antibodies. Type 1 lesions showed staining of all cell layers in the epithelium (with differences in the staining intensity of the basal compartment), whereas type 2 lesions exhibited mainly basal cell staining. Type 3 lesions did not stain with keratin 19 antibodies. In cystectomy 884-1, type 3 lesions exhibited the same immunophenotype as the SCC and may be regarded as precursors to the tumor. Basal cells in these lesions did not express keratin 13, suggesting that the tumor, which was also keratin 13 negative, may have arisen from the expansion of these cells. Similar results were observed with cystectomy 864-1, which showed carcinoma in situ of the SCC type. SCC 864-1 exhibited both keratin 19-negative and -positive cells, implying that the tumor arose from the expansion of the basal cell compartment of type 2 and 3 lesions. Besides providing with a novel strategy for revealing metaplastic lesions, our studies have shown that it is feasible to apply powerful proteomic technologies to the analysis of complex biological samples under conditions that are as close as possible to the in vivo situation. (+info)Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in situ and invasive transitional cell carcinoma. (7/920)
Although many genetic alterations are known to be associated with human transitional cell carcinoma (TCC) of the urinary bladder, relatively little is known about the roles of these molecular defects, singular or in combination, in bladder tumorigenesis. We have developed a transgenic mouse model of bladder tumorigenesis using a 3.6-kb promoter of uroplakin II gene to drive the urotheliums-specific expression of oncogenes. In this study, we demonstrate that transgenic mice bearing a low copy number of SV40T transgene developed bladder carcinoma in situ (CIS), whereas those bearing high copies developed CIS as well as invasive and metastatic TCCs. These results indicate that the SV40T inactivation of p53 and retinoblastoma gene products, defects frequently found in human bladder CIS and invasive TCCs, can cause the aggressive form of TCC. Our results also provide experimental proof that CIS is a precursor of invasive TCCs, thus supporting the concept of two distinct pathways of bladder tumorigenesis (papillary versus CIS/invasive TCC). This transgenic system can be used for the systematic dissection of the roles of individual or combinations of specific molecular events in bladder tumorigenesis. (+info)Specific p53 gene mutations in urinary bladder epithelium after the Chernobyl accident. (8/920)
After the Chernobyl accident, the incidence of urinary bladder cancers in the Ukraine population increased gradually from 26.2 to 36.1 per 100,000 between 1986 and 1996. Urinary bladder epithelium biopsied from 45 male patients with benign prostatic hyperplasia living in radiocontaminated areas of Ukraine demonstrated frequent severe urothelial dysplasia, carcinoma in situ, and a single invasive transitional cell carcinoma, combined with irradiation cystitis in 42 cases (93%). No neoplastic changes (carcinoma in situ or transitional cell carcinoma) were found in 10 patients from clean areas (areas without radiocontamination). DNA was extracted from the altered urothelium of selected paraffin-embedded specimens that showed obviously abnormal histology (3 cases) or intense p53 immunoreactivity (15 cases), and mutational analysis of exons 5-8 of the p53 gene was performed by PCR-single-strand conformational polymorphism analysis followed by DNA sequencing. Nine of 17 patients (53%) had one or more mutations in the altered urothelium. Urine sediment samples were also collected from the patients at 4-27 months after biopsy and analyzed by PCR-single-strand conformational polymorphism analysis or yeast functional assay, and identical or additional p53 mutations were found in four of five cases. Interestingly, a relative hot spot at codon 245 was found in five of nine (56%) cases with mutations, and 11 of the 13 mutations determined (73%) were G:C to A:T transitions at CpG dinucleotides, reported to be relatively infrequent (approximately 18%) in human urinary bladder cancers. Therefore, the frequent and specific p53 mutations found in these male patients may alert us to a future elevated occurrence of urinary bladder cancers in the radiocontaminated areas. (+info)
Immortalisation of Normal Human Urothelial Cells Compromises Differentiation Capacity. - University of Huddersfield Repository
Clinical Trial: Safety And Efficacy Of Js001 For Patients With Locally Advanced Or Metastatic Bladder Urothelial Carcinoma -...
British Library EThOS: The regulation of self-renewal in normal human urothelial cells
Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin. -...
Squamous differentiation in patients with superficial bladder urothelial carcinoma is associated with high risk of recurrence...
Ketamine-Induced Apoptosis in Normal Human Urothelial Cells - University of Huddersfield Repository
Papillary urothelial neoplasm of low malignant potential - Wikipedia
Frequent genetic alterations in simple urothelial hyperplasias of the bladder in patients with papillary urothelial carcinoma ...
JCI -
Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer
Vinflunine in routine clinical practice for the treatment of advanced or metastatic urothelial cell carcinoma - data from a...
Distribution of lymphocytes of the alpha(E)beta(7) phenotype and E-cadherin in normal human urothelium and bladder carcinomas. ...
Southgate, Professor Jenny - Biology, The University of York
E-GEOD-27014 - Kruppel-like factor 5 is Required for Urothelial Maturation - OmicsDI
Inhibitory effect of the urothelium/lamina propria on female porcine urethral contractility & effect of age<...
Papillary urothelial Papillary urothelial survival rate
Study Validating Ability of microRNAs to Predict Progression of Bladder Cancer Published in British Journal of Urology...
5-HT2A receptor enhancement of contractile activity of the porcine urothelium and lamina propria<...
Biomaterial comparison for hUCs | Journal of The Royal Society Interface
College of American Pathologists
- December 2001 Anatomic Abstracts
Urothelial cancer gene regulatory networks inferred from large-scale RNAseq, Bead and Oligo gene expression data - TUTCRIS -...
AMNIOTIC MEMBRANE SCAFFOLD ENRICHED WITH BLADDER FIBROBLASTS PROMOTES ESTABLISHMENT OF HIGHLY DIFFERENTIATED UROTHELIUM - EMC...
Urothelial Carcinoma Diagnostics Market to Reflect Impressive Growth Rate During 2017 - 2025 - Analytics News
2-Methoxyestradiol Induces Mitotic Arrest, Apoptosis, and Synergistic Cytotoxicity with Arsenic Trioxide in Human Urothelial...
Long-term low-dose exposure of human urothelial cells to sodium arsenite activates lipocalin-2 via promoter hypomethylation. |...
Urothelial cancer of Bladder in y... preview & related info | Mendeley
Thomas Powles, MD, on Urothelial Carcinoma: Results From the IMvigor211 Trial - The ASCO Post
S100P as a Marker for Urothelial Histogenesis: A Critical Review and Comparison with Novel and Traditional Urothelial...
Treatment Analysis on Urothelial carcinoma Market 2018: Therapeutic Survey and Clinical Management Report 2023 | Medgadget
Plus it
A promising target for immunotherapy? | Urology Times
Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin<...
Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems | BMC Medical Genomics | Full Text
Clinical Trials Dashboard
Plus it
bmp10 Protein, BMP10 bone morphogenetic protein 10 - Creative BioMart
A holistic comparative analysis of diagnostic tests for urothelial carcinoma: a study of Cxbladder Detect, UroVysion® FISH,...
Papillary urothelial hyperplasia icd 10 Traducere ovarian în română
Atypical Urothelial Cells Indeterminate for Neoplasia - Urothelial Cells
Plus it
JCI -
Volume 117, Issue 2
Moffitt Cancer Center: Clinical Trial 18509 | Moffitt
Most recent papers in the journal Analytical and Quantitative Cytopathology and Histopathology | Read by QxMD
Clinical Trial: NCT03785925 - My Cancer Genome
Development of a Non-Invasive DNA Methylation-Based Assay System for the Risk Assessment of Urothelial Carcinoma
Case 34
CiNii Articles -
Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma
https://www.medicalnewstoday.com/articles/319477.php
Urothelial carcinoma: Patterns of recurrence | 25th European Symposium on Urogenital Radiology 2018
A Study to Evaluate the Efficacy and Safety of Pemigatinib (INCB054828) in Subjects With Urothelial Carcinoma - (FIGHT-201) |...
Dr. Petrylak on Combinations with Pembrolizumab in Urothelial Carcinoma
Urinary system
See also: Urothelium. Under microscopy, the urinary system is covered in a unique lining called urothelium, a type of ... Urothelium covers most of the urinary system, including the renal pelvis, ureters, and bladder. ...
Transitional epithelium
... www.urothelium.com is an online resource for information about Human Urothelium and the "Biomimetic Urothelium" Urothelium at ... Urothelium is susceptible to carcinoma. Because the bladder is in contact with urine for extended periods, chemicals that ... Transitional epithelium lines the organs of the urinary system and is known here as urothelium. The bladder for example has a ... For example, current research paves the way for use of pluripotent stem cells to derive urothelium, as they are highly and ...
Facet cell
Umbrella cells form the outermost layer of the urothelium, which is a special type of epithelium found in the renal pelvis, the ... These increase the strength of the urothelium. Born, Martin; Pahner, Ingrid; Ahnert-Hilger, Gudrun; Jöns, Thomas (July 2003). " ...
UPK2
"Entrez Gene: UPK2 uroplakin 2". Lin JH, Wu XR, Kreibich G, Sun TT (1994). "Precursor sequence, processing, and urothelium- ... "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957-67. doi:10.1016/S0002-9440(10) ...
UPK1B
1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am. J. Pathol. 153 (6): 1957-67. doi:10.1016/ ... "Uroplakin gene expression by normal and neoplastic human urothelium". Am. J. Pathol. 153 (6): 1957-67. doi:10.1016/S0002-9440( ...
UPK3B (gene)
UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM ... 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of ...
Adrenergic receptor
... urethral sphincter urothelium and lamina propria bronchioles (although minor relative to the relaxing effect of β2 receptor on ... "Adrenoceptor function and expression in bladder urothelium and lamina propria". Urology. 81 (1): 211.e1-7. doi:10.1016/j. ...
Beta-2 adrenergic receptor
Moro C, Tajouri L, Chess-Williams R (January 2013). "Adrenoceptor function and expression in bladder urothelium and lamina ...
Urinary bladder
It is usually due to cancer of the urothelium, the cells that line the surface of the bladder. Bladder cancer is more common ... The inner wall of the bladder is called urothelium, a type of transitional epithelium formed by three to six layers of cells; ... Stromberga, Z; Chess-Williams, R; Moro, C (7 March 2019). "Histamine modulation of urinary bladder urothelium, lamina propria ... Moro, Christian; Tajouri, Lotti; Chess-Williams, Russ (2013). "Adrenoceptor Function and Expression in Bladder Urothelium and ...
Alpha-1 adrenergic receptor
Moro C, Tajouri L, Chess-Williams R (January 2013). "Adrenoceptor function and expression in bladder urothelium and lamina ... Secretion from sweat glands Contraction of the urinary bladder urothelium and lamina propria Na+ reabsorption from kidney ...
Beta-1 adrenergic receptor
"Adrenoceptor function and expression in bladder urothelium and lamina propria". Urology. 81 (1): 211.e1-7. doi:10.1016/j. ...
Staphylococcus saprophyticus
... saprophyticus has the capacity to selectively adhere to human urothelium. The adhesin for S. saprophyticus is a lactosamine ...
Invasive urothelial carcinoma
ISBN 978-3-642-16498-9. Urothelium at the US National Library of Medicine Medical Subject Headings (MeSH). ... 3 and in specimens of normal human urothelium and urothelial cancer". Cancer Cell Int. 12 (16): 16. doi:10.1186/1475-2867-12-16 ...
Serotonin
"2Areceptor enhancement of contractile activity of the porcine urothelium and lamina propria". International Journal of Urology ...
Analgesic nephropathy
Blohmé I, Johansson S (November 1981). "Renal pelvic neoplasms and atypical urothelium in patients with end-stage analgesic ...
Fibroblast growth factor receptor 3
... lessons from urothelium and skin". The Journal of Investigative Dermatology. 127 (7): 1572-3. doi:10.1038/sj.jid.5700772. PMID ...
Cora Sternberg
... and cisplatin for advanced transitional cell carcinoma of the urothelium. Efficacy and patterns of response and relapse". ...
ERBB4
Chow NH, Liu HS, Yang HB, Chan SH, Su IJ (Jun 1997). "Expression patterns of erbB receptor family in normal urothelium and ...
Urinary bladder
It can also contract for a long time whilst voiding, and it stays relaxed whilst the bladder is filling.[12] The urothelium and ... the urothelium (a form of transitional epithelium), a basement membrane, and the lamina propria.[7][8] The mucosal lining also ... "Adrenoceptor Function and Expression in Bladder Urothelium and Lamina Propria". Urology. 81 (1): 211.e1-211.e7. doi:10.1016/j. ...
Gallium nitrate
Preliminary studies in bladder carcinoma, carcinoma of the urothelium and lymphomas are also promising. Another interesting ...
Biological functions of nitric oxide
Moro, C; Leeds, C; Chess-Williams, R (January 2012). "Contractile activity of the bladder urothelium/lamina propria and its ...
Hematuria
The study should sufficiently evaluate the kidney and the urothelium lining the upper urinary tracts. If there are ...
Parasympathetic nervous system
They are also located on the detrusor muscle and urothelium of the bladder, causing contraction. The M4 muscarinic receptors: ...
Douglas Scherr
2005). "Five-alpha-reductase expression in benign and malignant urothelium: correlation with disease characteristics and ...
Bladder cancer
Aristolochic acid activates peroxidase in the urothelium and causes transversion mutation in the TP53 tumor suppressor gene. ...
Interstitial cystitis
Regardless of the origin, most people with IC/BPS struggle with a damaged urothelium, or bladder lining. When the surface ...
Histamine
Stromberga Z, Chess-Williams R, Moro C (March 2019). "Histamine modulation of urinary bladder urothelium, lamina propria and ...
Prostaglandin
"Prostaglandin E2 and F2alpha Modulate Urinary Bladder Urothelium, Lamina Propria and Detrusor Contractility via the FP Receptor ...
Urinary urgency
... often occurs as a result of irritation and/or inflammation of the bladder wall (urothelium). In interstitial ...
Colistin interactions with the mammalian urothelium. - PubMed - NCBI
Colistin interactions with the mammalian urothelium.. Lewis JR1, Lewis SA.. Author information. 1. Department of Physiology and ... Addition of colistin to the mucosal solution of the rabbit urinary bladder epithelium (urothelium) resulted in an increase in ... This finding suggests that at long exposure times, there is a toxic effect of colistin on the urothelium. ...
Kidney, Urothelium - Hyperplasia - Nonneoplastic Lesion Atlas
Kidney, Urothelium - Hyperplasia in a male F344/N rat from a chronic study. A focus of urothelial hyperplasia is present in the ... Kidney, Urothelium - Hyperplasia in a female F344/N rat from a chronic study. Urothelial hyperplasia in the renal pelvis is ... or secondary to an injury to the urothelium. Hyperplastic foci can be focal, multifocal, or diffuse. ...
In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells | PNAS
In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells. Diya B. Joseph, Anoop S. Chandrashekar, ... The capacity of Wolffian duct epithelial cells to replace damaged urothelium can potentially be leveraged for bladder ... In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells ... In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells ...
Urinary Bladder, Urothelium - Hyperplasia - Gallery - Nonneoplastic Lesion Atlas
Second-line systemic therapy and emerging drugs for metastatic transitional-cell carcinoma of the urothelium
... to high response rates but suboptimum overall survival for patients with advanced transitional-cell carcinoma of the urothelium ... Second-line systemic therapy and emerging drugs for metastatic transitional-cell carcinoma of the urothelium Lancet Oncol. 2010 ... to high response rates but suboptimum overall survival for patients with advanced transitional-cell carcinoma of the urothelium ...
Combination Chemotherapy Plus Filgrastim in Treating Patients With Locally Recurrent or Advanced Urothelium Cancer
Sorafenib in Treating Patients With Regional or Metastatic Cancer of the Urothelium
... progressive regional or metastatic cancer of the urothelium. Sorafeni ... mixed histologies containing a component of TCC) of the urothelium who have progressed on. one and only one prior systemic ... a component of transitional cell carcinoma of the urothelium (renal pelvis, ureter,. bladder, urethra) with manifestations of ...
Induction of Human Embryonic and Induced Pluripotent Stem Cells Into Urothelium. | California's Stem Cell Agency
The goal of this work was to develop an efficient in vitro protocol for the induction of hESCs into urothelium through an ... Additional hESC and hiPS cell lines could also be induced into urothelium using this in vitro system. These results demonstrate ... In vitro generation of human urothelium from stem cells would be a major advancement in the regenerative medicine field, ... Thus far, in vitro derivation of urothelium from human embryonic stem cells (hESCs) or human induced pluripotent stem (hiPS) ...
Mechanisms of Disease: involvement of the urothelium in bladder dysfunction
SENSORY ROLES OF THE UROTHELIUM. Transducer role of the urothelium. While the urothelium has been historically viewed primarily ... The urothelium is the epithelial lining of the urinary tract between the renal pelvis and the urinary bladder. Urothelium is ... within the urothelium indicate that NO has a role in the micturition reflex pathway.28,74 The release of NO from the urothelium ... RESPONSE OF THE UROTHELIUM TO INJURY. Basal cells, which are thought to be precursors for other cell types, normally exhibit a ...
Gemcitabine, Paclitaxel, and Cisplatin in Treating Patients With Advanced Cancer of the Urothelium
urothelium or local/regional recurrence after cystoprostatectomy.. - Determine response in patients who receive GTP as the ... Histologically confirmed transitional cell carcinoma (TCC) of the urothelium. (bladder, renal pelvis, or ureter) or TCC with ... Regional or distant metastases of TCC of the urothelium OR local/regional recurrence. after cystectomy, cystoprostatectomy, ... in Treatment of Advanced Transitional Cell Carcinoma of the Urothelium. Trial Phase:. Phase 2. Minimum Age:. 18 Years. Maximum ...
Tissue graft and method for urinary tract urothelium reconstruction and replacement - Patent # 5762966 - PatentGenius
Aquaporin water channels in the bladder urothelium as novel targets for treatment of lower urinary tract pathophysiology at...
Aquaporin water channels in the bladder urothelium as novel targets for treatment of lower urinary tract pathophysiology at ... Aquaporin water channels in the bladder urothelium as novel targets for treatment of lower urinary tract pathophysiology ... Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro. Eur Urol. 2009 Dec;56(6):1013 ... Recent studies suggested that the bladder urothelium, which was believed to be a poorly permeable urine-blood-barrier, is ...
Dasatinib Is Preclinically Active against Src-Overexpressing Human Transitional Cell Carcinoma of the Urothelium with Activated...
Dasatinib Is Preclinically Active against Src-Overexpressing Human Transitional Cell Carcinoma of the Urothelium with Activated ... Dasatinib Is Preclinically Active against Src-Overexpressing Human Transitional Cell Carcinoma of the Urothelium with Activated ... Dasatinib Is Preclinically Active against Src-Overexpressing Human Transitional Cell Carcinoma of the Urothelium with Activated ... Dasatinib Is Preclinically Active against Src-Overexpressing Human Transitional Cell Carcinoma of the Urothelium with Activated ...
Constructs of electrospun PLGA, compressed collagen and minced urothelium for minimally manipulated autologous bladder tissue...
"In vitro release of adenosine triphosphate from the urothelium of huma" by Vivek Kumar, Christopher R. Chapple et al.
... this rise was even more significant for the IDO urothelium (2416.7 ± 479.8 pmol/g [p , 0.005]) than for the NDO urothelium ( ... The carefully dissected urothelium was stimulated by mechanically stretching as well as electrically stimulating and the ATP; ... Conclusions - These experiments suggested a significant rise in ATP release from the urothelium of bladders with NDO as well as ... Objective - In this set of experiments, we have assessed the contribution of the urothelium to purinergic activity by ...
KAKEN - Research Projects | Transmitters derived from vesical urothelium ? in association with the pathogenesis ofInterstitial...
To achieve this purpose, weve focused on the transmitters expressed on urothelium or secreted into urine of human IC patients ... Journal Article] CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative ... Journal Article] CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative ... Transmitters derived from vesical urothelium ? in association with the pathogenesis ofInterstitial Cystitis. Research Project ...
Expression and Localisation of Aquaporin Water Channels in Human Urothelium In Situ and In Vitro - University of Huddersfield...
Urothelium is generally considered to be impermeable to water and constituents of urine. The possibility that human urothelium ... AQP3 was shown to be intensely expressed at cell borders in the basal and intermediate layers in both urothelium in situ and ... To investigate the expression of AQP water channels by human urothelium in situ, in proliferating urothelial cell cultures and ... This is the first study to demonstrate that AQPs are expressed by human urothelium, suggesting a potential role in ...
Electrolyte Levels in Neoplastic and Nonneoplastic Human Urothelium After Ouabain Treatment: X-Ray Microanalysis of Bulk...
Samples of neoplastic and nonneoplastic human urothelium were immediately frozen, incubated in Krebs saline and then frozen, ... Electrolyte Levels in Neoplastic and Nonneoplastic Human Urothelium After Ouabain Treatment: X-Ray Microanalysis of Bulk ... Electrolyte Levels in Neoplastic and Nonneoplastic Human Urothelium After Ouabain Treatment: X-Ray Microanalysis of Bulk ...
A phase II trial of gemcitabine plus carboplatin in advanced transitional cell carcinoma of the urothelium | BMC Cancer | Full...
... of the urothelium. Concern over cisplatin toxicity instigated a search for alternative regimens. The aim of the study was to ... plus carboplatin combination as first-line treatment in patients with advanced transitional cell carcinoma of the urothelium. ... A phase II trial of gemcitabine plus carboplatin in advanced transitional cell carcinoma of the urothelium. *Nong Xu. 1. , ... From January 2003 to June 2006, 41 patients with advanced transitional cell carcinoma(TCC) of the urothelium were entered onto ...
M-VAC: methotrexate (MTX), vinblastine (VLB), adriamycin (ADM), and cisplatin (DDP) for metastatic and node positive carcinoma...
Urothelium | Profiles RNS
"Urothelium" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Urothelium" by people in this website by year, and whether " ... Below are the most recent publications written about "Urothelium" by people in Profiles. ...
Urothelium | Dominion Internal Medicine
Substance P induces localization of MIF/α1-inhibitor-3 complexes to umbrella cells via paracellular transit through the...
In SP-treated rats, A1-I3 in the bladder increased and A1-I3 was observed traversing through the urothelium. Umbrella cells ... A1-I3 immunostaining was observed in interstitial spaces throughout the bladder (including submucosa) but not urothelium in ... showed A1-I3 in the interstitial spaces and in the lamina propria immediately below the urothelium, but not in the urothelium. ... but no A1-I3 was observed in the urothelium. Strong MIF staining was observed in the urothelium while weak MIF immunostaining ...
Frontiers | Increased Expression of Interleukin-6 Family Members and Receptors in Urinary Bladder with Cyclophosphamide-Induced...
CYP-induced cystitis significantly (p ≤ 0.01) increased LIF-immunoreactivity (IR) in urothelium, detrusor, and suburoth... ... CYP-induced cystitis significantly (p ≤ 0.01) increased LIF-immunoreactivity (IR) in urothelium, detrusor, and suburothelial ... plexus whereas increased gp130-IR was only observed in urothelium and detrusor. These studies suggest that IL-6 and LIF may be ... Q-PCR analyses revealed significant (p ≤ 0.01) CYP duration- and tissue- (e.g., urothelium, detrusor) dependent increases in ...
Inorganic arsenic-induced intramitochondrial granules in mouse urothelium<...
Inorganic arsenic-induced intramitochondrial granules in mouse urothelium. Shugo Suzuki, Lora L. Arnold, David Muirhead, Lu ... Inorganic arsenic-induced intramitochondrial granules in mouse urothelium. Toxicologic Pathology. 2008 Dec;36(7):999-1005. ... Inorganic arsenic-induced intramitochondrial granules in mouse urothelium. / Suzuki, Shugo; Arnold, Lora L.; Muirhead, David; ... Fingerprint Dive into the research topics of Inorganic arsenic-induced intramitochondrial granules in mouse urothelium. ...
Plus it
... and urothelium, our studies demonstrated that major sites of NO release were the urothelium and afferent nerves (Birder et al ... the location of afferent nerves that terminate in close proximity to the urothelium suggests that urothelium-derived NO may ... 2000) Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br J Pharmacol 129:416-419. ... To establish the urothelium as a possible source of NO, the effects of β-AR agonists were examined on cultured urinary bladder ...
Program Project: Growth, Differentiation and Disease of Urothelium - Tung-Tien Sun
Program Project: Growth, Differentiation and Disease of Urothelium Sun, Tung-Tien New York University, New York, NY, United ... The apical surface of urinary bladder urothelium plays a key role in urothelial function. Our team will study, in a highly ... 2013) Retinoid signaling in progenitors controls specification and regeneration of the urothelium. Dev Cell 26:469-82 ... 2010) Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary ...
Methotrexate, vinblastine, doxorubicin, and cisplatin for advanced transitional cell carcinoma of the urothelium. Efficacy and...
A phase II trial of gemcitabine plus carboplatin in advanced transitional cell carcinoma of the urothelium. Nong Xu, Xiao Chen ... Methotrexate, vinblastine, doxorubicin, and cisplatin for advanced transitional cell carcinoma of the urothelium. Efficacy and ... and cisplatin for advanced transitional cell carcinoma of the urothelium. Efficacy and patterns of response and relapse.}, ... II/III study of cabazitaxel versus vinflunine in metastatic or locally advanced transitional cell carcinoma of the urothelium ( ...
Prerequisite for successful surgical outcome in urothelium lined seromuscular colocystoplasty<...
Jung, HJ, Lee, H, Im, YJ, Lee, YS, Hong, CH & Han, SW 2012, Prerequisite for successful surgical outcome in urothelium lined ... N2 - Purpose: Urothelium lined seromuscular colocystoplasty is an ideal method of augmentation cystoplasty that avoids various ... AB - Purpose: Urothelium lined seromuscular colocystoplasty is an ideal method of augmentation cystoplasty that avoids various ... Purpose: Urothelium lined seromuscular colocystoplasty is an ideal method of augmentation cystoplasty that avoids various ...
Lamina propriaRenalVitroUreterEpithelialNormal urotheliumMammalianDifferentiationEpitheliumUrineTissueInjury to the urotheliumCarcinomaPorcine bladderMouse urotheliumEntire urotheliumIntact urotheliumDetrusor smooth muscleCystitisLesionsCarcinomasApical surfaceContractionsHyperplasiaHESCsInhibitoryAfferentCytologyNeoplasticAbstractAquaporinCancerGenitourinaryUmbrellaIlealExpressesLymphocytesInterstitialMalignantCellTumourTissuesOveractivityBarrier
Lamina propria10
- The aim of this study was to determine the effects of 5-HT onthe contractile activity of the urothelium and lamina propria, and the likely mediatingreceptor. (edu.au)
- Strips of porcine urothelium and lamina propria were suspended in 10mL organbaths filled with warm Krebs-bicarbonate solution. (edu.au)
- 5-HTproduced concentration-dependent contractions in porcine urothelium and lamina propria andthis response was unlikely to be mediated by receptors 5-HT2, 5-HT3 or 5-HT4. (edu.au)
- This study assessed the actions of PGE 2 , PGF 2 , PGD 2 , TXA 2 , and PGI 2 on urinary bladder urothelium with lamina propria (U&LP), and detrusor smooth muscle. (biomedcentral.com)
- Prostaglandins are synthesised in both the bladder urothelium with lamina propria (U&LP) and in detrusor smooth muscle in response to stretch, nerve stimulation, U&LP damage or other inflammatory mediators [ 10 , 11 ]. (biomedcentral.com)
- Specifically, of interest is to determine how the actions of the prostaglandins affect urothelium with lamina propria that is separated from the detrusor smooth muscle. (biomedcentral.com)
- Therefore, this study aimed to assess the influence of PGE 2 , PGF 2α , PGD 2 , TXA 2 and PGI 2 on the urinary bladder urothelium with lamina propria and detrusor smooth muscle contractions and phasic activity. (biomedcentral.com)
- Occasional T lymphocytes (CD3(+)) were seen in normal urothelium and lamina propria. (ox.ac.uk)
- [7] The inner side of the bladder is lined with a mucosal membrane consisting of a surface glycocalyx that protects the cells beneath it from urine, the urothelium (a form of transitional epithelium ), a basement membrane , and the lamina propria . (wikipedia.org)
- The lamina propria is a thin layer of connective tissue that surrounds the urothelium of each renal pelvis and ureter. (cancer.ca)
Renal5
- The urothelium is the epithelial lining of the urinary tract between the renal pelvis and the urinary bladder. (pubmedcentralcanada.ca)
- Urothelium covers most of the urinary system, including the renal pelvis, ureters, and bladder. (wikipedia.org)
- Results Mitomycin C permeation across the ureteral urothelium was significantly greater than across the bladder and renal pelvis urothelium (9.07 vs 0.94 and 3.61 μg cm-2, respectively). (cardiff.ac.uk)
- Umbrella cells form the outermost layer of the urothelium, which is a special type of epithelium found in the renal pelvis, the ureters, and the urethra. (wikipedia.org)
- The urothelium is the inner lining of each renal pelvis and ureter. (cancer.ca)
Vitro13
- In vitro generation of human urothelium from stem cells would be a major advancement in the regenerative medicine field, providing alternate nonurologic and/or nonautologous tissue sources for bladder grafts. (ca.gov)
- Thus far, in vitro derivation of urothelium from human embryonic stem cells (hESCs) or human induced pluripotent stem (hiPS) cells has not been reported. (ca.gov)
- The goal of this work was to develop an efficient in vitro protocol for the induction of hESCs into urothelium through an intermediary definitive endoderm step and free of matrices and cell contact. (ca.gov)
- Additional hESC and hiPS cell lines could also be induced into urothelium using this in vitro system. (ca.gov)
- These results demonstrate that derivation and propagation of urothelium from hESCs and hiPS cells can be efficiently accomplished in vitro in the absence of matrices, cell contact, or adult cell signaling and that the induction process appears to mimic normal differentiation. (ca.gov)
- Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro. (findaphd.com)
- In vitro release of adenosine triphosphate from the urothelium of huma" by Vivek Kumar, Christopher R. Chapple et al. (edu.au)
- AQP3 was shown to be intensely expressed at cell borders in the basal and intermediate layers in both urothelium in situ and differentiated tissue constructs in vitro. (hud.ac.uk)
- Bioengineering of bladder tissue, particularly for those patients who have advanced bladder disease, requires a source of urothelium that is healthy, capable of significant proliferation in vitro and immunologically tolerated upon transplant. (elsevier.com)
- As pluripotent stem cells have the potential to fulfill such criteria, they provide a critical cell source from which urothelium might be derived in vitro and used clinically. (elsevier.com)
- Herein, we describe the in vitro differentiation of urothelium from the H9 human embryonic stem cell (hESC) line through the definitive endoderm (DE) phase via selective culture techniques. (elsevier.com)
- CONCLUSIONS The relaxation responses of the bladder to isoprenaline do not appear to involve the urothelium or NO release in vitro. (shu.ac.uk)
- We investigated the presence of functional ß1, ß2 and ß3-adrenoceptor in urothelium and detrusor muscle of human bladder through in vitro pharmacology of selective ß3 adrenoceptor agonist solabegron. (bvsalud.org)
Ureter3
- Ex vivo porcine ureter is significantly more permeable to mitomycin C than bladder urothelium and consequently higher mitomycin C tissue concentrations can be achieved after topical application. (cardiff.ac.uk)
- Human ureter wall lined by stratified urothelium and transitional epithelium, H&E stain. (gettyimages.be)
- This is a specialized type of epithelium found lining organs that can stretch, such as the urothelium that lines the bladder and ureter of mammals. (bionity.com)
Epithelial5
- The capacity of Wolffian duct epithelial cells to replace damaged urothelium can potentially be leveraged for bladder replacement therapies which are often necessitated in patients with carcinoma or neurogenic bladder. (pnas.org)
- Alteration of the epithelial and mesenchymal cell signaling contribution through noncell contact coculture or conditioned media did not enhance the production of urothelium. (ca.gov)
- Over the past eleven years, we have worked as a Program Project team consisting of four investigators with diverse expertise in the areas of epithelial cell biology, structural biology and membrane trafficking to study, in several closely interrelated projects, the cell and molecular biology and diseases of mammalian urothelium. (grantome.com)
- The trigone is the triangular area of the bladder bound by the ureteral orifices and the internal urethral sphincter, which is normally lined by urothelium, a type of transitional epithelial tissue. (medscape.com)
- The inner epithelial compartment, the urothelium, is a three-tiered dilatable yet sealing tissue with a single layer of cuboidal basal cells (B-cells), one or two layers of similarly shaped intermediate cells (I-cells), and a luminal layer of large squamous superficial cells (S-cells) 1 . (nature.com)
Normal urothelium3
- It has been previously shown that p63 is expressed in normal urothelium. (nih.gov)
- The primary aim of this work was to survey normal urothelium and transitional cell carcinoma (TCC) for the presence of T lymphocytes expressing the intraepithelial, CD103(+) phenotype. (ox.ac.uk)
- T lymphocytes of the CD103(+) phenotype are present in normal urothelium where they may play a role in immunosurveillance. (ox.ac.uk)
Mammalian4
- Colistin interactions with the mammalian urothelium. (nih.gov)
- Our research focuses on, as a central and unifying theme, a group of integral membrane proteins called uroplakins that represent major differentiation markers of mammalian urothelium. (grantome.com)
- Data in this study correlate with the theory that mammalian upper tract urothelium represents a different cell lineage than that of the bladder and it is innately more permeable to mitomycin C. (cardiff.ac.uk)
- Uroplakins (UPs) are integral membrane proteins that are synthesized as the major differentiation products of mammalian urothelium. (aacrjournals.org)
Differentiation1
- These data indicate that in contrast to the skin and prostate, p63 is not required for formation of a bladder epithelium but is indispensable for the specific differentiation of a transitional urothelium. (nih.gov)
Epithelium5
- Addition of colistin to the mucosal solution of the rabbit urinary bladder epithelium (urothelium) resulted in an increase in the transepithelial conductance. (nih.gov)
- Under microscopy, the urinary system is covered in a unique lining called urothelium , a type of transitional epithelium . (wikipedia.org)
- Professor Southgate is a cell/molecular biologist who studies human urothelium, the epithelium of the urinary bladder. (york.ac.uk)
- Transitional epithelium lines the organs of the urinary system and is known here as urothelium. (wikipedia.org)
- The urothelium is also called the transitional epithelium. (cancer.ca)
Urine4
- Recent studies suggested that the bladder urothelium, which was believed to be a poorly permeable urine-blood-barrier, is indeed able to modify composition and volume of urine. (findaphd.com)
- To achieve this purpose, we've focused on the transmitters expressed on urothelium or secreted into urine of human IC patients. (nii.ac.jp)
- Urothelium is generally considered to be impermeable to water and constituents of urine. (hud.ac.uk)
- Few studies have examined the carcinogenicity of chemicals toward the urinary bladder in hamsters, and the effect of diet on hamster urine and urothelium has not been reported. (nebraska.edu)
Tissue11
- Although the urothelium maintains a tight barrier to ion and solute flux, a number of local factors (e.g. tissue pH, mechanical or chemical trauma, and bacterial infection) can modulate the barrier function of the urothelium. (pubmedcentralcanada.ca)
- Cells from minced tissue migrated, expanded and re-organised to a confluent cell layer on the top of the construct after two weeks and formed a multilayered urothelium after four weeks. (diva-portal.org)
- To investigate the expression of AQP water channels by human urothelium in situ, in proliferating urothelial cell cultures and in differentiated tissue constructs. (hud.ac.uk)
- Q-PCR analyses revealed significant ( p ≤ 0.01) CYP duration- and tissue- (e.g., urothelium, detrusor) dependent increases in LIF, IL-6, IL-6Rα, LIFR, and gp130 mRNA expression. (frontiersin.org)
- Although AM stroma scaffold allows establishment of differentiated urothelium, its orientation probably does not favour AM integration into surrounding tissue, if applied in vivo . (emc-proceedings.com)
- Amniotic membrane scaffolds enable the development of tissue-engineered urothelium with molecular and ultrastructural properties comparable to that of native urothelium. (emc-proceedings.com)
- Purpose We compared the relative permeability of upper urinary tract and bladder urothelium to mitomycin C. Materials and Methods Ex vivo porcine bladder, ureters and kidneys were dissected out and filled with 1 mg ml-1 mitomycin C. At 60 minutes the organs were emptied and excised tissue samples were sectioned parallel to the urothelium. (cardiff.ac.uk)
- MATERIAL AND METHODS Paired (in the presence or absence of urothelium) longitudinal strips of pig bladder dome were set up in tissue baths and the developed tension recorded. (shu.ac.uk)
- Twenty-six samples of normal control urothelium obtained from patients without urothelial carcinomas (C), 47 samples of non-cancerous urothelium without noticeable morphological changes obtained from patients with urothelial carcinomas (N), and 46 samples of the corresponding cancerous tissue (T) in the learning cohort and 64 N samples in the validation cohort, i.e. 183 tissue samples in total, were analyzed. (elsevier.com)
- [ 7 , 8 ] Kvist et al did not find estrogen receptors in 36 historically collected samples of squamous metaplasia of the bladder urothelium, although the authors posited that relatively few existing receptors might have been destroyed in the tissue preparation process. (medscape.com)
- A layer of tissue and blood vessels surrounding the urothelium. (cancersa.org.au)
Injury to the urothelium2
- or secondary to an injury to the urothelium. (nih.gov)
- The involvement of prostaglandins in bladder physiology was first recognised from their release after urinary bladder distension or injury to the urothelium [ 1 , 2 ]. (biomedcentral.com)
Carcinoma16
- Front-line platinum-based combination chemotherapy leads to high response rates but suboptimum overall survival for patients with advanced transitional-cell carcinoma of the urothelium. (nih.gov)
- 43-9006 in patients with progressing regional or metastatic transitional cell carcinoma (or mixed histologies containing a component of TCC) of the urothelium who have progressed on one and only one prior systemic chemotherapy regimen for metastatic disease. (knowcancer.com)
- Determine response to gemcitabine hydrochloride, paclitaxel, and cisplatin (GTP) among patients with regional or distant metastases of transitional cell carcinoma of the urothelium or local/regional recurrence after cystoprostatectomy. (knowcancer.com)
- Front-line chemotherapy for metastatic transitional cell carcinoma (TCC) of the urothelium with cisplatin-based combinations including methotrexate, vinblastine, doxorubicin, cisplatin, or gemcitabine and cisplatin yields a median survival of ∼15 months ( 2 ). (aacrjournals.org)
- Recent studies have demonstrated the effectiveness of cisplatin-based combinations in patients with advanced transitional cell carcinoma(TCC) of the urothelium. (biomedcentral.com)
- The aim of the study was to evaluate the activity and tolerability of gemcitabine plus carboplatin combination as first-line treatment in patients with advanced transitional cell carcinoma of the urothelium. (biomedcentral.com)
- On the basis of these considerations, we conducted a single-arm phase II study to evaluate the objective response rate and tolerability of the combination of gemcitabine and carboplatin in Chinese patients with advanced transitional cell carcinoma of the urothelium. (biomedcentral.com)
- M-VAC: methotrexate (MTX), vinblastine (VLB), adriamycin (ADM), and cisplatin (DDP) for metastatic and node positive carcinoma of the urothelium. (cornell.edu)
- A randomized phase II/III study of cabazitaxel versus vinflunine in metastatic or locally advanced transitional cell carcinoma of the urothelium (SECAVIN). (semanticscholar.org)
- Purpose: To assess the efficacy and toxicity of single-agent paclitaxel as first-line chemotherapy in patients with locally advanced or metastatic transitional-cell carcinoma of the urothelium. (elsevier.com)
- We performed an immunohistochemical study to examine the expression of c-erb B-2 in non-neoplastic urothelium (n = 12) and transitional cell carcinoma of the urinary bladder (n = 82). (ncku.edu.tw)
- Urothelium is susceptible to carcinoma. (wikipedia.org)
- Transitional cell carcinoma of the urothelium. (centerwatch.com)
- Not sure for Transitional cell carcinoma of the urothelium. (centerwatch.com)
- To determine a safety profile of temsirolimus in combination with cisplatin and gemcitabine hydrochloride, including dose-limiting toxicities (DLTs) and maximum-tolerated dose (MTD) in patients with locally advanced and/or metastatic transitional cell carcinoma of the urothelium. (clinicaltrials.gov)
- Human urothelial carcinoma is thought to arise from a field change that affects the entire urothelium. (aacrjournals.org)
Porcine bladder1
- Porcine urothelial cells cultured on de-epithelized AM scaffolds enriched with porcine bladder fibroblasts (A) established highly differentiated urothelium, whereas those maintained on AM scaffolds without integrated fibroblast (B) differentiated partially. (emc-proceedings.com)
Mouse urothelium1
- Here, we show that conditional inactivation of both RB1 alleles in mouse urothelium failed to accelerate urothelial proliferation. (aacrjournals.org)
Entire urothelium1
- Although the entire urothelium is at risk of urotoxicity, the bladder, which serves as a reservoir, is most frequently affected, because the contact time between acrolein and the urothelium is greatest at this site. (medscape.com)
Intact urothelium4
- OBJECTIVES To investigate whether the responses of the pig bladder to isoprenaline (a nonselective β-adrenoceptor agonist) are influenced by the presence of an intact urothelium and whether any influence might be attributed to the release of nitric oxide (NO), since stimulation of β-adrenoceptors induces a direct relaxation of detrusor smooth muscle and β-adrenoceptors are also present on the urothelium. (shu.ac.uk)
- However, contractile responses to carbachol were inhibited in the presence of an intact urothelium, and this might reflect the release of an inhibitory factor other than NO. (shu.ac.uk)
- The presence of an intact urothelium on isolated bladder strips inhibited contractions induced by carbachol but not KCl. (edu.au)
- Contractions of a urothelium-denuded muscle strip were inhibited in the presence of a second bladder strip with an intact urothelium, but not if the second strip was denuded. (edu.au)
Detrusor smooth muscle3
- The function of the bladder urothelium in modulating contractile responses of the underlying detrusor smooth muscle to muscarinic stimulation has been examined in the pig bladder. (edu.au)
- Saturation curves for [ 3 H]-QNB binding demonstrated a greater muscarinic receptor density in the urothelium than in the detrusor smooth muscle. (edu.au)
- Saturation curves for [ 3H]-QNB binding demonstrated a greater muscarinic receptor density in the urothelium than in the detrusor smooth muscle. (edu.au)
Cystitis2
- CYP-induced cystitis significantly ( p ≤ 0.01) increased LIF-immunoreactivity (IR) in urothelium, detrusor, and suburothelial plexus whereas increased gp130-IR was only observed in urothelium and detrusor. (frontiersin.org)
- chronic cystitis with glandlike metaplasia of urothelium. (drugs.com)
Lesions3
- This difference in nuclear size may be used as a tool for differentiating the flat urothelial lesions from reactive urothelium in daily practice. (biomedcentral.com)
- Pathologic studies have shown patient symptoms are correlated with lesions of the urothelium lining the bladder and the accumulation of mast cells throughout all layers. (massgeneral.org)
- The tumour must be differentiated from a number of proliferative lesions of the urothelium. (hindawi.com)
Carcinomas2
- Distribution of lymphocytes of the alpha(E)beta(7) phenotype and E-cadherin in normal human urothelium and bladder carcinomas. (ox.ac.uk)
- Consistent with this, urothelium-specific expression of a constitutively active Ha-ras oncogene in transgenic mice elicits urothelial hyperplasia, approximately half of which evolves, over a 28-month period, to low-grade, superficial papillary carcinomas that bear strong resemblance to the human counterparts ( 14 ). (aacrjournals.org)
Apical surface2
- 1 , 2 , 8 , 9 The apical surface of the urothelium is also covered with a sulfated poly saccharide glycosaminoglycan layer that is thought to act as a nonspecific anti-adherence factor and as a defense mechanism against infection. (pubmedcentralcanada.ca)
- The apical surface of urinary bladder urothelium plays a key role in urothelial function. (grantome.com)
Contractions1
- The urothelium-induced inhibition of contractions was not prevented in the presence of L-NOARG, methylene blue, indomethacin, propranolol, suramin, TEA or apamin. (edu.au)
Hyperplasia1
- Kidney, Urothelium - Hyperplasia in a male F344/N rat from a chronic study. (nih.gov)
HESCs1
- The protocol can be used to derive urothelium from other hESCs or human-induced pluripotent stem cells. (elsevier.com)
Inhibitory2
- The data suggest the presence of a diffusable, urothelium-derived inhibitory factor, which could not be identified but appears to be neither nitric oxide, a cyclo-oxygenase product, a catecholamine, adenosine, GABA nor an EDHF sensitive to apamin. (edu.au)
- Guan NN, Gustafsson LE, Svennersten K. Inhibitory effects of urothelium-related factors. (springer.com)
Afferent1
- Localization of afferent nerves next to the urothelium suggests that urothelial cells could be targets for neurotransmitters released from bladder nerves or that chemicals released by urothelial cells could alter afferent nerve excitability. (pubmedcentralcanada.ca)
Cytology2
- Of the 18 patients who completed the 12-week intensive course, 13 (72.2%) showed a complete response, defined as negative cystoscopy including urothelium biopsy and negative cytology, and entered the 12-months maintenance phase. (prnewswire.com)
- Complete response (CR) was defined as negative cystoscopy, including urothelium biopsy and negative cytology. (prnewswire.com)
Neoplastic3
- Electrolyte Levels in Neoplastic and Nonneoplastic Human Urothelium After Ouabain Treatment: X-Ray Microanalysis of Bulk Hydrated Samples. (lancs.ac.uk)
- Samples of neoplastic and nonneoplastic human urothelium were immediately frozen, incubated in Krebs' saline and then frozen, or incubated in 10-5 mol/L ouabain in Krebs' saline and then frozen. (lancs.ac.uk)
- c-erb B-2 protein was localized in superficial and some intermediate cells of non-neoplastic urothelium. (ncku.edu.tw)
Abstract1
- abstract = "Purpose: Urothelium lined seromuscular colocystoplasty is an ideal method of augmentation cystoplasty that avoids various complications caused by the use of gastrointestinal segments. (elsevier.com)
Aquaporin1
- The possibility that human urothelium expresses aquaporin (AQP) water channels as the basis for water and solute transport has not previously been investigated. (hud.ac.uk)
Cancer4
- Phase II trial to study the effectiveness of combination chemotherapy with gemcitabine and docetaxel plus filgrastim in treating patients who have locally recurrent or advanced urothelium cancer. (bioportfolio.com)
- The aim of this study was to establish permutation for cancer risk estimation in the urothelium. (elsevier.com)
- Receiver operating characteristic curve analysis confirmed the feasibility of cancer risk estimation to identify urothelium at the precancerous stage by DNA methylation quantification. (elsevier.com)
- PURPOSE: This phase I/II trial is studying the side effects and best dose of temsirolimus given together with gemcitabine hydrochloride and cisplatin as first-line therapy in treating patients with locally advanced and/or metastatic transitional cell cancer of the urothelium. (clinicaltrials.gov)
Genitourinary1
- The Northwestern Memorial Hospital (Chicago, IL) pathology database was searched for random, nonconsecutive patients over the period of April 2014 to April 2015 who had a biopsy- or surgical-resection diagnosis by a genitourinary specialty pathologist (X.Y.) of reactive urothelium, low grade UC (LG UC) and high grade UC (HG UC) and urothelial CIS (WHO, 2004). (biomedcentral.com)
Umbrella2
- 1 , 6 , 7 The barrier function of the urothelium is dependent on several features of the umbrella cell layer: these features include tight-junction complexes that reduce the movement of ions and solutes between cells, and specialized lipid molecules and uroplakin proteins in the apical membrane, which reduce the permeability of the cells to small molecules (e.g. water, urea, protons). (pubmedcentralcanada.ca)
- 11 For example, when protamine sulfate was used to damage selectively only the umbrella cell layer, it was shown that the urothelium rapidly undergoes both functional and structural changes in order to restore the barrier. (pubmedcentralcanada.ca)
Ileal1
- Both MUC1 and MUC4 were up-regulated in transposed ileal segments, genes expressed by the normal human urothelium. (ox.ac.uk)
Expresses1
- This is supported by the fact that the bladder urothelium expresses the transmembrane water channels (aquaporins). (findaphd.com)
Lymphocytes1
- In the urothelium the majority of these T lymphocytes (71%) were also CD8(+) and of these 68% expressed the CD103 marker. (ox.ac.uk)
Interstitial1
- A1-I3 immunostaining was observed in interstitial spaces throughout the bladder (including submucosa) but not urothelium in intact and saline-treated rats. (biomedcentral.com)
Malignant1
- One theory suggests that the multiple tumors are of monoclonal origin, arising from a single malignant transformed cell which proliferates and spreads throughout the urothelium either by intraluminal spread with secondary implantation at different sites within the urinary tract or by intraepithelial migration. (aacrjournals.org)
Cell3
- A total of 1085 urothelial cell nuclei from 60 cases were measured from reactive urothelium, low grade (LG) UC, HG UC and CIS. (biomedcentral.com)
- Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin. (illumina.com)
- The urothelium is no longer regarded as a passive barrier but rather as a complex "sensory web" transducing signals from inside the viscus (and in response to neuronal and local changes) through the activation of cell-surface receptors [ 1 ]. (hindawi.com)
Tumour1
- Nuclear receptor-activated transcriptomic signatures in human urothelium for the deconvolution of tumour transcriptomes. (hopkinsmedicine.org)
Tissues2
- In relaxation experiments, isoprenaline relaxed carbachol pre-contracted tissues by ≈75%, and the potency and maximum relaxation were similar in the absence and presence of the urothelium. (shu.ac.uk)
- In the presence of the urothelium there was a greater shift with 0.1 µm isoprenaline than in denuded tissues. (shu.ac.uk)
Overactivity1
- Objective - In this set of experiments, we have assessed the contribution of the urothelium to purinergic activity by quantifying the amount of adenosine triphosphate (ATP) released from the urothelium of patients with idiopathic detrusor overactivity (IDO) and with neurogenic detrusor overactivity (NDO) and comparing these releases to those of controls. (edu.au)
Barrier1
- Although the urinary bladder urothelium has classically been thought of as a passive barrier to ions and solutes, a number of novel properties have been recently attributed to urothelial cells. (pubmedcentralcanada.ca)