An enzyme that catalyzes the phosphorylation of uridine and cytidine to uridine 5'-phosphate and cytidine 5'-phosphate, respectively. ATP, dUTP, dGTP, and dATP are effective phosphate donors. EC 2.7.1.48.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.
An enzyme that catalyzes the transfer of ribose from uridine to orthophosphate, forming uracil and ribose 1-phosphate.
An enzyme that catalyzes the deamination of guanine to form xanthine. EC 3.5.4.3.
A pyrimidine nucleoside that is composed of the base CYTOSINE linked to the five-carbon sugar D-RIBOSE.
A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.
Serves as the biological precursor of insect chitin, of muramic acid in bacterial cell walls, and of sialic acids in mammalian glycoproteins.
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.
Pyrimidines with a RIBOSE attached that can be phosphorylated to PYRIMIDINE NUCLEOTIDES.
Pyrimidines with a RIBOSE and phosphate attached that can polymerize to form DNA and RNA.
Situations or conditions requiring immediate intervention to avoid serious adverse results.
Enzymes that catalyze the hydrolysis of ester bonds within RNA. EC 3.1.-.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
The portion of an interactive computer program that issues messages to and receives commands from a user.
An enzyme that catalyzes the endonucleolytic cleavage of pancreatic ribonucleic acids to 3'-phosphomono- and oligonucleotides ending in cytidylic or uridylic acids with 2',3'-cyclic phosphate intermediates. EC 3.1.27.5.
Sequential operating programs and data which instruct the functioning of a digital computer.
Any materials used in providing care specifically in the hospital.
Compounds that bind to and stimulate PURINERGIC P2Y RECEPTORS. Included under this heading are agonists for specific P2Y receptor subtypes.
Compounds that bind to and block the stimulation of PURINERGIC P2X RECEPTORS. Included under this heading are antagonists for specific P2X receptor subtypes.
A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.
The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.
A publication issued at stated, more or less regular, intervals.
Individual's rights to obtain and use information collected or generated by others.
Value of all final goods and services produced in a country in one year.

The biosynthesis of transfer RNA in insects. II. Isolation of transfer RNA precursors from the posterior silk gland of Bombyx mori. (1/2242)

The occurrence of precursors to tRNA in the post-polysomal fraction of the posterior silk gland of Bombyx mori was demonstrated by pulse-chase labeling and DNA-RNA hybridization competition experiments. These precursors had molecular sizes ranging from 4S to 5S on polyacrylamide gel electrophoresis. Analysis of the incorporation of the methyl group from [methyl-14C]methionine revealed that a radioactive peak on polyacrylamide gel appeared in the 4.5S region during brief labeling. This suggested that some methylation occurred at the 4.5S precursor step.  (+info)

[3H]gemcitabine uptake by nucleoside transporters in a human head and neck squamous carcinoma cell line. (2/2242)

Cellular uptake of many chemotherapeutic nucleoside analogs is dependent on the activity of a family of nucleoside transport proteins located in the cell plasma membrane. In the present study, we examined the role of these transporters in the accumulation of gemcitabine by a human head and neck squamous carcinoma cell line. The uptake of [3H]gemcitibine was compared with that of [3H]uridine and [3H]formycin B in the parent cell line (HN-5a) and in a gemcitabine-resistant variant (GEM-8e). The HN-5a and GEM-8e cells were similar in their transport characteristics and expressed predominantly the es (equilibrative, inhibitor-sensitive) transporter subtype; less than 10% of the influx of [3H]formycin B or [3H]uridine was mediated by the ei (equilibrative inhibitor-resistant) system, and there was no evidence for Na+-dependent nucleoside transporters. [3H]Gemcitabine (10 microM) entered these cells via both the es and ei transporters with an initial rate of uptake similar to that seen with the use of [3H]formycin B or [3H]uridine. In addition, ATP-replete cells accumulated significantly less [3H]gemcitabine than did ATP-depleted cells, which is indicative of an active efflux mechanism for gemcitabine. These results show that gemcitabine is a substrate for both the es and ei nucleoside transporters of HN-5a and GEM-8e cells and that gemcitabine resistance of the GEM-8e cells cannot be attributed to changes in transporter activity. Further studies to define the characteristics of the putative efflux mechanism are clearly warranted because this system has the potential to significantly affect the clinical efficacy of gemcitabine.  (+info)

Nucleoside-3'-phosphotriesters as key intermediates for the oligoribonucleotide synthesis. III. An improved preparation of nucleoside 3'-phosphotriesters, their 1H NMR characterization and new conditions for removal of 2-cyanoethyl group. (3/2242)

An improved procedure for the transformation of 5'-O-monomethoxytrityl-2'-O-acetyl-3'-phosphates of uridine la, inosine ib and 6-N-benzoyladenosine lc into corresponding 3'/2,2,2-trichloroethyl, 2-cyanoethyl/-phosphates iiaic is reported. H NMR characterization of nucleoside 3'-phosphotriesters is presented. New conditions i.e. anhydrous triethylamine-pyridine treatment have been found for the selective removal of 2-cyanoethyl group from nucleoside 3'-phosphotriesters in the presence of neighbouring 2'-O-acetyl one.  (+info)

Binding of neuronal ELAV-like proteins to the uridine-rich sequence in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA. (4/2242)

Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that is involved in the pathogenesis of several human CNS disorders. The AU-rich element (ARE) in the 3'-untranslated region (UTR) of TNF-alpha mRNA is implicated in post-transcriptional control of TNF-alpha. In this study, we showed that a human neuronal ELAV-like protein binds to the ARE in the 3'-UTR of TNF-alpha mRNA. The protein binds to the uridine stretch in AUUUA pentanucleotides inside the ARE in the 3'-UTR of TNF-alpha mRNA. The TNF-alpha mRNA-binding region in the protein appears to be identical to the c-myc and IL-3 mRNA-binding regions. Moreover, this study showed that in vitro treatment of neuroblastoma cells with interleukin-4 (IL-4), which inhibits TNF-alpha production, reduced the expression of the neuronal ELAV-like proteins. These results suggest that the expression of neuronal ELAV-like proteins may be closely associated with the expression of TNF-alpha in neuronal cells.  (+info)

Use of tracheal organ cultures in toxicity testing. (5/2242)

Fragments of tracheal epithelium alone or in continuity with connective tissues, can be maintained in culture medium and used for short term or long term studies of toxicity of a variety of chemicals. Large numbers of uniform cultures are prepared with the aid of a slicing device or by application of simple method for dissecting sheets of epithelium free from underlying cartilage. The cultures may be placed in an exposure chamber-incubator mounted on a microscope stage and monitored continually for ciliostasis and exfoliation of cells. Morphology is further studied by fixation of selected specimens and preparation for light microscopy and electron microscopy. Synthetic functions are evaluated by autoradiographic measurement of incorporation of radioactive precursors into macromolecules and other dynamic features are indirectly assessed by histochemical and histoenzymatic methods. Short-term studies using these several techniques have shown that ciliostasis does not correlate with cell injury in all instances, and a long-term study has demonstrated dose dependence of a cytotoxic agent when duration of culture viability is measured. The method lends itself to a broad range of investigations in which dose, period of exposure, and role of cofactors must be independently and quantitatively assessed.  (+info)

Biochemical studies of isolated hamster tracheal epithelium. (6/2242)

The epithelial lining of respiratory air passageways is a primary target tissue for toxicity and carcinogenesis in man and in animal models of human disease. The importance of this target tissue was the basis for development of methods to study its biochemistry, and with this information to distinguish the unique properties of this tissue from properties common to all cell types. Biochemical methods employed labeling of macromolecules in isolated hamster treacheas during brief (less than 4 hr) incubation in vitro. Studies of RNA metabolism in isolated tracheas demonstrated a pattern of maturation of ribosomal RNA like that shown for other cell types. Alterations in RNA metabolism were observed in isolated tracheas obtained from vitamin A-deficient hamsters and hamsters previously treated by intratracheal administration of benzo[a]pyrene (BP) plus ferric oxide (Fe2O3) in vivo. Studies with toyocamycin, actinomycin D, and alpha-amanitin, all inhibitors of RNA metabolism, were performed to characterize the class of RNA molecules with a decreased proportion of labeling in tracheas from vitamin A deficient hamsters. In another series of experiments, BP was shown to bind to DNA in epithelial cells of isolated tracheas. The quantity of BP binding was increased by prior intratracheal treatment of hamsters with BP plus Fe2O3 in vivo, this induced binding was inhibited by addition of 7,8-benzoflavone to the incubation medium. Increased BP binding was also observed in isolated tracheas from hamsters believed to be in states of increased susceptibility to respiratory carcinogenesis in vivo. The results show that biochemical studies are feasible with this tissue. Furthermore, a number of questions of importance with regard to this target epithelium are best studied directly in its constituent cells.  (+info)

The uridine in "U-turn": contributions to tRNA-ribosomal binding. (7/2242)

"U-turns" represent an important class of structural motifs in the RNA world, wherein a uridine is involved in an abrupt change in the direction of the polynucleotide backbone. In the crystal structure of yeast tRNAPhe, the invariant uridine at position 33 (U33), adjacent to the anticodon, stabilizes the exemplar U-turn with three non-Watson-Crick interactions: hydrogen bonding of the 2'-OH to N7 of A35 and the N3-H to A36-phosphate, and stacking between C32 and A35-phosphate. The functional importance of each noncanonical interaction was determined by assaying the ribosomal binding affinities of tRNAPhe anticodon stem and loop domains (ASLs) with substitutions at U33. An unsubstituted ASL bound 30S ribosomal subunits with an affinity (Kd = 140+/-50 nM) comparable to that of native yeast tRNAPhe (Kd = 100+/-20 nM). However, the binding affinities of ASLs with dU-33 (no 2'-OH) and C-33 (no N3-H) were significantly reduced (2,930+/-140 nM and 2,190+/-300 nM, respectively). Surprisingly, the ASL with N3-methyluridine-33 (no N3-H) bound ribosomes with a high affinity (Kd = 220+/-20 nM). In contrast, ASLs constructed with position 33 uridine analogs in nonstacking, nonnative, and constrained conformations, dihydrouridine (C2'-endo), 6-methyluridine (syn) and 2'O-methyluridine (C3'-endo) had almost undetectable binding. The inability of ASLs with 6-methyluridine-33 and 2'O-methyluridine-33 to bind ribosomes was not attributable to any thermal instability of the RNAs. These results demonstrate that proton donations by the N3-H and 2'OH groups of U33 are not absolutely required for ribosomal binding. Rather, the results suggest that the overall uridine conformation, including a dynamic (C3'-endo > C2'-endo) sugar pucker, anti conformation, and ability of uracil to stack between C32 and A35-phosphate, are the contributing factors to a functional U-turn.  (+info)

The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells. (8/2242)

Deficiency in DNA mismatch repair (MMR) is found in some hereditary (hereditary nonpolyposis colorectal cancer) and sporadic colon cancers as well as other common solid cancers. MMR deficiency has recently been shown to impart cellular resistance to multiple chemical agents, many of which are commonly used in cancer chemotherapy. It is therefore of interest to find an approach that selectively targets cells that have lost the ability to perform MMR. In this study, we examine the response of MMR-proficient (hMLH1+) and MMR-deficient (hMLH1-) colon carcinoma cell lines to the halogenated thymidine (dThd) analogues iododeoxyuridine (IdUrd) and bromodeoxyuridine (BrdUrd) before and after irradiation. These dThd analogues are used clinically as experimental sensitizing agents in radioresistant human cancers, and there is a direct correlation between the levels of dThd analogue DNA incorporation and tumor radiosensitization. In contrast to the well-characterized, marked increase in cytotoxicity (> 1 log cell kill) found with 6-thioguanine exposures in HCT116/3-6 (hMLH1+) cells compared to HCT116 (hMLH1-) cells, we found only modest cytotoxicity (10-20% cell kill) in both cell lines when treated with IdUrd or BrdUrd for 1 population doubling. Upon further analysis, the levels of halogenated dThd analogues in DNA were significantly lower (two to three times lower) in HCT116/3-6 cells than in HCT116 cells, and similar results were found in Mlh1+/+ spontaneously immortalized murine embryonic fibroblasts and fibroblasts from Mlh1 knockout mice. As a result of the higher levels of the dThd analogue in DNA, there was an increase in radiation sensitivity in HCT116 cells but not in HCT116/3-6 cells after pretreatment with IdUrd or BrdUrd when compared to treatment with radiation alone. Additionally, we found no differences in the cellular metabolic pathways for dThd analogue DNA incorporation because the enzyme activities of dThd kinase and thymidylate synthase, as well as the levels of triphosphate pools, were similar in HCT116 and HCT116/3-6 cells. These data suggest that the hMLH1 protein may participate in the recognition and subsequent removal of halogenated dThd analogues from DNA. Consequently, whereas MMR-deficient cells and tumor xenografts have shown intrinsic resistance to a large number of chemotherapeutic agents, the 5-halogenated dThd analogues appear to selectively target such cells for potential enhanced radiation sensitivity.  (+info)

5-Bromouridine 5′-triphosphate sodium salt (5-BrUTP); >= 93%; 5-Bromouridine 5′-triphosphate (5-BrUTP) is used to measure transcription via labeling of ribonucleic acids (RNA);
Treatment of HIV infection with nucleoside analogue reverse transcriptase inhibitors (NRTIs) has been associated with numerous toxicities that have been attributed to impaired mitochondrial function secondary to a reduction in the levels of mitochondrial DNA (mtDNA). Abnormalities in mitochondrial function have been implicated in the development of insulin resistance in patients with HIV infection and have also been hypothesized to underlie many of the pathophysiologic features of type 2 diabetes mellitus in non-HIV infected individuals.. Uridine, a pyrimidine nucleoside that plays an essential role in the synthesis of RNA and other key physiologic processes, has been proposed as a therapy for NRTI-induced mitochondrial dysfunction. Uridine supplementation protected bone marrow cells from the toxicity of zidovudine, normalized the growth of neurons exposed to NRTIs, and abrogated mitochondrial toxicity of NRTIs in HepG2 cells in vitro. A food supplement called NucleomaxX®, extracted from the ...
Treatment of HIV infection with nucleoside analogue reverse transcriptase inhibitors (NRTIs) has been associated with numerous toxicities that have been attributed to impaired mitochondrial function secondary to a reduction in the levels of mitochondrial DNA (mtDNA). Abnormalities in mitochondrial function have been implicated in the development of insulin resistance in patients with HIV infection and have also been hypothesized to underlie many of the pathophysiologic features of type 2 diabetes mellitus in non-HIV infected individuals.. Uridine, a pyrimidine nucleoside that plays an essential role in the synthesis of RNA and other key physiologic processes, has been proposed as a therapy for NRTI-induced mitochondrial dysfunction. Uridine supplementation protected bone marrow cells from the toxicity of zidovudine, normalized the growth of neurons exposed to NRTIs, and abrogated mitochondrial toxicity of NRTIs in HepG2 cells in vitro. A food supplement called NucleomaxX®, extracted from the ...
TY - JOUR. T1 - Effect of Uridine on Response of 5-Azacytidine-resistant Human Leukemic Cells to Inhibitors of de Novo Pyrimidine Synthesis. AU - Grant, S.. AU - Bhalla, K.. AU - Gleyzer, M.. PY - 1984/12/1. Y1 - 1984/12/1. N2 - A uridine-cytidine kinase-deficient human promyelocytic leukemic subline (HL-60-5-aza-Cyd) has been isolated which is highly resistant to the antileukemic agent 5-azacytidine. Resistant cells exposed to 10-5 M 5-azacytidine for 2 hr exhibit a marked reduction in both the total intracellular accumulation of 5-azacytidine (11.9 versus 156.0 pmol/106 cells) as well as its incorporation into RNA (3.1 versus 43.4 pmol/μg D-ribose) compared to the parent line. These biochemical changes are associated with nearly a 100-fold decrease in sensitivity to the growth inhibitory effects of 5-azacytidine (concentration of drug associated with a 50% reduction in cell growth, 3.5 x 10-5 versus 5.0 x 10-7 M). 5-Azacytidine-resistant cells exhibit cross-resistance to 3-deazauridine, ...
The initial rate of thymidine-3H incorporation into the acid-soluble pool by cultured Novikoff rat hepatoma cells was investigated as a function of the thymidine concentration in the medium. Below, but not above 2 µM, thymidine incorporation followed normal Michaelis-Menten kinetics at 22°, 27°, 32°, and 37°C with an apparent Km of 0.5 µM, and the Vmax values increased with an average Q10 of 1.8 with an increase in temperature. The intracellular acid-soluble 3H was associated solely with thymine nucleotides (mainly deoxythymidine triphosphate [dTTP]). Between 2 and 200 µM, on the other hand, the initial rate of thymidine incorporation increased linearly with an increase in thymidine concentration in the medium and was about the same at all four temperatures. Pretreatment of the cells with 40 or 100 µM p-chloromercuribenzoate for 15 min or heat-shock (49.5°C, 5 min) markedly reduced the saturable component of uptake without affecting the unsaturable component or the phosphorylation of ...
The coat protein from the MS2 bacteriophage plays a dual role by encapsidating viral RNA and also by binding RNA as a translational repressor. In order to study the isolated dimer in a conformation not influenced by capsid interactions, a mutant molecule was crystallized that is defective in capsid assembly but is an active repressor. The unassembled dimer crystallized in the space group P21212 with a = 76.2, b = 55.7, and c = 28.4 A. In these crystals, monomers were related by twofold symmetry. When this dimer was co-crystallized with 5-bromouridine, crystals formed in space group R3 with a = b = 155.9 A, c = 29.9 A, gamma = 120 degrees; the dimer was the asymmetric unit.
Dyskerin mediates both the changes of uridine on ribosomal and little nuclear RNAs as well as the stabilization from the telomerase RNA element (TERC). although it had not been within amplified tumors (= 0.929). Likewise the association between dyskerin manifestation and success was within cases not really bearing gene amplification (= 0.009) and had not been seen in amplified tumors (= 0.584). These outcomes indicate how the impact of dyskerin manifestation on tumor medical outcome is associated with its role for the maintenance of high degrees of gene) HCl salt NOP10 NHP2 and GAR1. A lot of the genes encoding telomerase parts have been discovered to become mutated in various types of Dyskeratosis Congenita (DC) (2) a uncommon multisystemic inherited symptoms seen as a mucocutaneous abnormalities predisposition to tumor and bone tissue marrow failing the latter becoming the principal reason behind mortality (reviewed in [2-4]). Telomere shortening has HCl salt been linked in many ways to ...
China premium quality and best price 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione CAS:1463-10-1 bulk Supplier, 5-Methyluridine manufacturer and 5-Methyluridine factory with good price, We supply 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione CAS:1463-10-1 and we manufacture and produce 5-Methyluridine from China, Contact us for your requirements of 5-Methyluridine and Ribothymidine
Suspensions of lymph node cells were prepared from immunized and from unimmunized rabbits. In a totally synthetic medium at 37°C, these cells incorporated 3H-uridine into RNA at an initially rapid linear rate without lag. After 60 to 90 min of incubation, the rate of uridine incorporation changed to a second linear rate which was about 9% of the initial rate. Maximal initial rates of 3H-uridine incorporation were observed 5 days after immunization, though differences were small between cells from immunized and nonimmune animals. Sucrose gradient analyses of whole cell RNA revealed that the major classes of cellular RNA contained significant radio-activity and antigen-stimulated cells revealed predominant labeling in a 12 to 13S fraction. These experiments provide a reasonable approach to the preparation and isolation of high specific activity RNA for use in the RNA-DNA hybridization studies or in the functional characterization of various classes of RNA implicated in immune responses.. ...
Byrne R.T., Jenkins H.T., Peters D.T., Whelan F., Stowell J., Aziz N., Kasatsky P., Rodnina M.V., Koonin E.V., Konevega A.L., Antson A.A.. The reduction of specific uridines to dihydrouridine is one of the most common modifications in tRNA. Increased levels of the dihydrouridine modification are associated with cancer. Dihydrouridine synthases (Dus) from different subfamilies selectively reduce distinct uridines, located at spatially unique positions of folded tRNA, into dihydrouridine. Because the catalytic center of all Dus enzymes is conserved, it is unclear how the same protein fold can be reprogrammed to ensure that nucleotides exposed at spatially distinct faces of tRNA can be accommodated in the same active site. We show that the Escherichia coli DusC is specific toward U16 of tRNA. Unexpectedly, crystal structures of DusC complexes with tRNA(Phe) and tRNA(Trp) show that Dus subfamilies that selectively modify U16 or U20 in tRNA adopt identical folds but bind their respective tRNA ...
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...ANN ARBOR Mich. When researchers sequence the RNA of cancer cells t...But other than spotting a few known instigators what does it mean? Is...After more than a decade of work researchers at the University of Mic...The method involves a compound called bromouridine which can be used ...,New,technique,sheds,light,on,RNA,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Dihydrouridine Synthase 1-Like (S. Cerevisiae) (DUS1L) Peptid. Spezies: Human. Quelle: Synthetic. Jetzt Produkt ABIN976024 bestellen.
Creative-Proteomics offer cas 58-96-8 [1-2H]uridine. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
GERALD FINK, RICHARD BRIMACOMBE; Synthesis and Applications of a Two-Step Reagent Forming Cross-links between Ribonucleic Acid and Protein. Biochem Soc Trans 1 December 1975; 3 (6): 1014-1015. doi: https://doi.org/10.1042/bst0031014. Download citation file:. ...
Looking for online definition of 5-Methyluridine monophosphate in the Medical Dictionary? 5-Methyluridine monophosphate explanation free. What is 5-Methyluridine monophosphate? Meaning of 5-Methyluridine monophosphate medical term. What does 5-Methyluridine monophosphate mean?
Rat liver parenchymal cells express Na+-dependent and Na+-independent nucleoside transport activity. The Na+-dependent component shows kinetic properties and substrate specificity similar to those reported for plasma membrane vesicles [Ruiz-Montasell, Casado, Felipe and Pastor-Anglada (1992) J. Membr. Biol. 128, 227-233]. This transport activity shows apparent Km values for uridine in the range 8-13 μM and a Vmax of 246 pmol of uridine per 3 min per 106 cells. Most nucleosides, including the analogue formycin B, cis-inhibit Na+-dependent uridine transport, although thymidine and cytidine are poor inhibitors. Inosine and adenosine inhibit Na+-dependent uridine uptake in a dose-dependent manner, reaching total inhibition. Guanosine also inhibits Na+-dependent uridine uptake, although there is some residual transport activity (35% of the control values) that is resistant to high concentrations of guanosine but may be inhibited by low concentrations of adenosine. The transport activity that is ...
We examined the biochemical pathways whereby oral uridine-5-monophosphate (UMP) increases membrane phosphatide synthesis in brains of gerbils. We previously showed that supplementing PC12 cells with uridine caused concentration-related increases in CDP-choline levels, and that this effect was mediated by elevations in intracellular uridine triphosphate (UTP) and cytidine triphosphate (CTP). In the present study, adult gerbils received UMP (1 mmol/kg), a constituent of human breast milk and infant formulas, by gavage, and plasma samples and brains were collected for assay between 5 min and 8 h thereafter. Thirty minutes after gavage, plasma uridine levels were increased from 6.6 +/- 0.58 to 32.7 +/- 1.85 microM (P , 0.001), and brain uridine from 22.6 +/- 2.9 to 89.1 +/- 8.82 pmol/mg tissue (P , 0.001). UMP also significantly increased plasma and brain cytidine levels; however, both basally and following UMP, these levels were much lower than those of uridine. Brain UTP, CTP, and CDP-choline ...
Because of previous data suggesting that aminoacyl-tRNA synthetases make a transient Michael adduct with a specific uridine residue in the tRNA structure, (Schoemaker, H.J.P., and Schimmel, P.R. (1977) Biochemistry 16, 5454-5460) attempts were made to find simple model systems in which this reaction might be studied in more detail. In the course of these investigations, it was found that Escherichia coli Ile-tRNA synthetase catalyzes cleavage of the glycosidic bond of 5-bromouridine. At pH 7.5, ambient temperatures, the turnover number is roughly 5/h. 5-Fluoro-, 5-chloro-, and 5-iodouridine are also cleaved in an analogous way by Ile-tRNA synthetase. In the case of uridine, conversion of uridine to uracil and ribose was also detected, but with a smaller turnover number. Three other E. coli and one mammalian aminoacyl-tRNA synthetases were also examined and all were found to catalyze glycosidic bond cleavage of 5-bromouridine. The data indicate that, in general, synthetases have a catalytic ...
Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others.
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E coli 16S RNA pseudouridine 516 synthase: acts only on uridine 516 of E. coli 16S RNA; amino acid sequence given in first source
Each metabolic step is catalyzed by a par- ticular enzyme, whose production is the responsibility of a single gene. A mutation in the gene alters the activity of the protein for which it is responsible. A modification in the hypothesis is needed to accommodate proteins that consist of more than one subunit. If the subunits are all the same, the protein is a homomultimer, repre- sented by a single gene. If the subunits are dif- ferent, the protein is a heteromultimer. Stated as a more general rule applicable to any het- eromultimeric protein, the one gene : one enzyme hypothesis becomes more precisely expressed as one gene: one polypeptide chain. Different isolates of a particular viroid strain vary from one another, and the change may affect the phenotype of infected cells. For exam- pIe, the mild and severe strains of PSTV differ by three nucleotide substitutions. Viroids resemble viruses in having herita- ble nucleic acid genomes. They fulfill the crite- ria for genetic information. Yet ...
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for URIDINE- 5- O- (1-THIOTRIPHOSPHATE), SP- ISOMER ( SP-UTP-?-S ) (CAS No. 71214-29-4)
Detection of circulating ribonucleic acid (cRNA) from blood is an unmet need in clinical diagnostics. Here we describe methods that...
DUS2 overexpression lysate, 0.1 mg. Transient overexpression lysate of dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) (DUS2L)
இரைபோ கருவமிலம் அல்லது ஆர்.என்.ஏ. (RNA - Ribonucleic acid) என்பது ஒரு கருவமிலம் ஆகும். இதனை இரைபோக் கருக்காடி, ஐங்கரிமவினியக் கருக்காடி, ஐவினியக் கருக்காடி, ஐங்கரிமவினியக் கருவமிலம், ஐவினியக் கருவமிலம் என்ற பெயர்கள் கொண்டும் அழைக்கலாம். இது அனைத்து உயிரினங்களுக்கும் தேவையான நான்கு பெரிய பிரிவுகளில் அடங்கும் பருமூலக்கூறுகளில் ஒன்றான கருவமிலங்களில் ஒன்றாகும். இவையும் டி.என்.ஏ யைப் ...
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Virus mutants (NDVpi) isolated from L cells persistently infected with the Herts strain of Newcastle disease virus have been previously reported by this laboratory to differ from the wild-type virus (NDVo) in several physical and biological properties. It has now been determined that, in addition to these differences, the NDVpi mutants are also spontaneously selected temperature-sensitive mutants. The temperature sensitivity of 10 NDVpi clones was confirmed by temperature inhibition, plaquing efficiency, and single-cycle yield experiments. The cut-off temperature, at which more than 90% of virus replication is inhibited was between 41 and 42 C. All 10 NDVpi clones were also found to be defective in virus-specific ribonucleic acid (RNA) synthesis in infected chick embryo cells at 42 C and are tentatively classified as RNA−. The possible relationships of the temperature sensitivity, the other NDVpi properties, and the maintenance of the persistently infected state are discussed. ...
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
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Kaufmann, Berwind Petersen, McDonald, Margaret R., Gay, Helen (November 1948) The ribonucleic acid content of chromosomes. Genetics, 33 (6). p. 615. ...
Although I am fully convinced of the truth of the views given in this volume, I by no means expect to convince experienced naturalists whose minds are stocked with a multitude of facts all viewed, during a long course of years, from a point of view directly opposite to mine. It is so easy to hide our ignorance under such expressions as plan of creation, unity of design, etc., and to think that we give an explanation when we only restate a fact. Any one whose disposition leads him to attach more weight to unexplained difficulties than to the explanation of a certain number of facts will certainly reject the theory. ...
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Blair, D G. and Rainnie, D J., Specific activities of uridine kinase and uridine phosphorylase of ehrlich ascites carcinoma cells during tumor growth. Abstr. (1969). Subject Strain Bibliography 1969. 23 ...
Get information, facts, and pictures about Nucleic acid synthesis at Encyclopedia.com. Make research projects and school reports about Nucleic acid synthesis easy with credible articles from our FREE, online encyclopedia and dictionary.
Read about the chemical and physical properties of Diphosphoric Acid 1-beta-Glycerol Ester 2-(Uridine-5-yl)ester,bis-Triethylammonium Salt. Get Diphosphoric Acid 1-beta-Glycerol Ester 2-(Uridine-5-yl)ester,bis-Triethylammonium Salt molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
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The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
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Oblaka d mu stoupaj z vozu libanonsk ho exministra a b val ho fa k estansk ch milic Elieho Hubajky (vlevo) a auta jeho t lesn ch str c po pumov m atent tu, kter byl sp ch n v Bejr tu. P i v buchu zahynul Hubajka a nejm n t i jeho t lesn str ci, dal ch p t lid bylo zran no. (24. ledna 2002) ...
၀မ္းသြားခ်င္တာကိုေအာင့္ထားျခင္းက နာတာရွည္ ၀မ္းခ်ဳပ္ေရာဂါကိုျဖစ္ေစႏိုင္ျပီး ခြဲစိတ္မွဳ ခံယူရတဲ့အထိျဖစ္ႏုိင္
Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok P-Y, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM et al. 2009. Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2). J Pharmacol Exp Ther, 328 (3), pp. 699-707. , Show Abstract , Read more The human concentrative nucleoside transporter 2 (CNT2) plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs. We identified genetic variation in the basal promoter region of CNT2 and characterized the function of the variants. We screened DNA from an ethnically diverse population and identified five basal promoter variants in CNT2. Three major haplotypes in the CNT2 basal promoter region were identified and were found at different allele frequencies in various ethnic groups. The common promoter variants and haplotypes were constructed and ...
To verify the assumption of a specific and potent drug action on de novo pyrimidine biosynthesis, isolated dihydroorotate dehydrogenase (DHO-DH) (EC 1.3.3.1) was exposed to Brequinar Sodium (6-fluoro-2-(2-fluoro-1,1-biphenyl-4-yl)-3-methyl-4-quinoline carboxylic acid sodium salt, NSC 368 390) (Brequinar). The membrane-bound DHO-DH was purified to apparent homogeneity (25,000-fold) from rat liver mitochondria in six steps via detergent extraction and subsequent chromatography using the dye ligand Matrex Gel Orange A. Using molecular mechanistic studies (MM2) this ligand was found to mimic closely the stereochemical conformation of Brequinar. SDS-PAGE revealed two protein bands for the purified enzyme with apparent molecular masses of 58 (major) and 68 kDa (minor). In vitro, two modes of action of the DHO-DH are possible: (i) acting as a dehydrogenase in the presence of ubiquinone as proximal electron acceptor and (ii) direct reaction with oxygen as oxidase. A novel assay for the measurement of the
TY - JOUR. T1 - 5-Deoxy-5-fluorouridine. T2 - A model substrate for the study of pyrimidine nucleoside transport. AU - Bowen, D.. AU - Enigbokan, M. A.. AU - Diasio, R. B.. PY - 1982/1/1. Y1 - 1982/1/1. UR - http://www.scopus.com/inward/record.url?scp=0020049866&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0020049866&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0020049866. VL - Vol. 23. SP - No. 864. JO - Proceedings of the American Association for Cancer Research. JF - Proceedings of the American Association for Cancer Research. ER - ...
TY - JOUR. T1 - Changes in RNA and protein metabolism preceding onset of hemoglobin synthesis in cultured friend leukemia cells. AU - Sherton, Corinne C.. AU - Kabat, David. PY - 1976. Y1 - 1976. N2 - We have studied the hematopoietic process which is induced by dimethyl sulfoxide (Me2SO) in the Ostertag FSD-1 line of Friend erythroleukemia (FL) cells and have observed several changes that precede the onset of hemoglobin synthesis at 48 hr. Although cellular viability, mitotic rate, and deoxyribonucleic acid content are unaffected by our induction procedure, the induced cells become progressively smaller, and by 96 hr contain only 55% as much ribonucleic acid and 60-70% as much protein as control cells. The decline in ribonucleic acid content is significant by 24 hr and affects 4S and ribosomal ribonucleic acids in a noncoordinated manner throughout the hematopoietic process. Furthermore, incorporation of radioactive uridine into the 45S precursor of ribosomal ribonucleic acid is specifically ...
Candidate: Brequinar. Type: Orally available, potent, and selective small molecule dihydroorotate dehydrogenase (DHODH) inhibitor designed to block host cell de novo pyrimidine biosynthesis.. Status: Clear Creek said September 1 it received FDA clearance on an IND application to study its lead drug candidate brequinar as a COVID-19 treatment, and has dosed the first patient in the Phase Ia CRISIS trial (NCT04425252).. The randomized, open label, multi-center study will enroll up to 24 patients hospitalized with COVID-19, with the aim of assessing the preliminary efficacy, safety, and tolerability of brequinar. The study will assign participants 1:2 to standard of care or standard of care plus five once-daily oral doses of 100 mg brequinar. The primary endpoint is safety/tolerability measured by rates of post randomization adverse events and hematology/chemistry safety labs. The trial was recruiting at four sites in Hartford, CT; Jacksonville, FL; Philadelphia; and Tampa, FL.. Clear Creek cited ...
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Pseudouridine (abbreviated by the Greek letter psi- Ψ or the letter Q)[1] is an isomer of the nucleoside uridine in which the uracil is attached via a carbon-carbon instead of a nitrogen-carbon glycosidic bond. (In this configuration uracil is sometimes referred to as pseudouracil.) It is the most prevalent of the over one hundred different modified nucleosides found in RNA.[2] Ψ is found in all species and in many classes of RNA.[3][4][5][6] Ψ is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation.[7] Currently, about ∼ 9500 pseudouridine (Ψ) modifications have been identified in mammals and yeast and deposited in RMBase database.[8] ...
Fingerprint Dive into the research topics of Scleraxis messenger ribonucleic acid is expressed in C2C12 myoblasts and its level is down-regulated by bone morphogenetic protein-2 (BMP2). Together they form a unique fingerprint. ...
An image featured on an article on the Wikipedia for Schools from SOS Children: English: Violin first position fingering chart, with
casSAR Dugability of A0KI53 | mnmA | tRNA-specific 2-thiouridylase MnmA - Also known as MNMA_AERHH, mnmA, trmU. Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
Biomolecular nuclear magnetic resonance (NMR) spectroscopy allows the characterisation of structural and dynamic properties of ribonucleic acids (RNAs) in solution
8/3(THU) NIKE SPOTの店頭販売方法に関してのお知らせになります。 AM11時00分よりKinetics Harajuku店頭にて通常販売となります。 ※お客様のお並び状況によって整理券を配布させて頂きます … 続きを読む →. ...
8/3(THU) NIKE SPOTの店頭販売方法に関してのお知らせになります。 AM11時00分よりKinetics Harajuku店頭にて通常販売となります。 ※お客様のお並び状況によって整理券を配布させて頂きます … 続きを読む →. ...
A16AX13 Uridine triacetate. A16AX14 Migalastat. QA16Q Other alimentary tract and metabolism products for veterinary use[edit]. ...
... uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, and ... Strominger JL, Smith MS (1959). "Uridine diphosphoacetylglucosamine pyrophosphorylase". J. Biol. Chem. 234 (7): 1822-1827. doi: ... Pattabiraman TN, Bachhawat BK (June 1961). "Purification of uridine diphosphoacetylglucosamine pyrophosphorylase from sheep ... Other names in common use include UDP-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine ...
... uridine diphosphate glucose dehydrogenase, UDP-D-glucose dehydrogenase, and uridine diphosphate D-glucose dehydrogenase. In ... Axelrod J, Kalckar HM, Maxwell ES, Strominger JL (Jan 1957). "Enzymatic formation of uridine diphosphoglucuronic acid". The ... Kalckar HM, Maxwell ES, Strominger JL (Nov 1956). "Some properties of uridine diphosphoglucose dehydrogenase". Archives of ... Other names in common use include: UDP-glucose dehydrogenase, uridine diphosphoglucose dehydrogenase, UDPG dehydrogenase, UDPG: ...
Glaser L, Melo A, Paul R (1987). "Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor". J. Biol. ...
Zea CJ, Camci-Unal G, Pohl NL (July 2008). "Thermodynamics of binding of divalent magnesium and manganese to uridine phosphates ... Sundararajan TA, Rapin AM, Kalckar HM (December 1962). "Biochemical observations on E. coli mutants defective in uridine ... Turnquist, Richard L.; Hansen, R. Gaurth (1973-01-01). "2 Uridine Diphosphoryl Glucose Pyrophosphorylase". In Boyer, Paul D. ( ... Tsuboi KK, Fukunaga K, Petricciani JC (February 1969). "Purification and specific kinetic properties of erythrocyte uridine ...
"Entrez Gene: UPP1 uridine phosphorylase 1". Russell, R L; Cao D; Zhang D; Handschumacher R E; Pizzorno G (April 2001). "Uridine ... 2002). "Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update". Biochim. ... Uridine phosphorylase 1 is an enzyme that in humans is encoded by the UPP1 gene. UPP1 has been shown to interact with Vimentin ... 2002). "Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma". Cancer. 94 (11 ...
Russell RL, Cao D, Zhang D, Handschumacher RE, Pizzorno G (April 2001). "Uridine phosphorylase association with vimentin. ...
Changed: 'ImageFile' ('Uridine diphosphate galactose.svg' -, 'UDP-Galactose.svg'). *17:31:44 (2, 3, 4) (EDIT) User:Yikrazuul ( ... contribs, talk) edited Uridine_diphosphate_glucose (diff, hist). Changed: 'ImageFile' ('Uridine diphosphate glucose.png' -, ' ... 17:30:13 (2, 3, 4) (EDIT) User:Yikrazuul (contribs, talk) edited Uridine_diphosphate_galactose (diff, hist). ...
They begin with a 5' uridine. The remaining 20 nucleotides are diverse. They are modified at their 3′-terminal ribose. See Piwi ...
The sequence contains no uridine residues; they are replaced by 1-methyl-3'-pseudouridylyl. The 2P proline substitutions in the ...
". "Entrez Gene: UMPS uridine monophosphate synthetase". "Entrez Gene: UCK2 uridine-cytidine kinase 2". Chitrakar I, Kim- ...
Ankel H, Feingold DS (1965). "Biosynthesis of uridine diphosphate D-xylose. 1. Uridine diphosphate glucuronate carboxy-lyase of ... Other names in common use include uridine-diphosphoglucuronate decarboxylase, and UDP-D-glucuronate carboxy-lyase. This enzyme ...
UCKL1: encoding enzyme Uridine-cytidine kinase-like 1. *UQCC: encoding enzyme Ubiquinol-cytochrome c reductase complex ...
Phospho-N-acetylmuramyl-pentapeptide translocase (uridine monophosphate)". Biochemistry. 5 (1): 82-93. doi:10.1021/bi00865a012 ...
Rudick VL, Weisman RA (1974). "Uridine diphosphate glucose pyrophosphorylase of Acanthamoeba castellanii. Purification, kinetic ...
... uridine diphosphoacetylpyruvoylglucosamine reductase, uridine diphospho-N-acetylglucosamine-enolpyruvate reductase, uridine-5'- ... Taku A, Anwar RA (1973). "Biosynthesis of uridine diphospho-N-acetylmuramic acid. IV Activation of uridine diphospho-N- ... Taku A, Gunetileke KG, Anwar RA (1970). "Biosynthesis of uridine diphospho-N-acetylmuramic acid. 3 Purification and properties ... of uridine diphospho-N-acetylenolpyruvyl-glucosamine reductase". J. Biol. Chem. 245 (19): 5012-6. PMID 4394163. van Heijenoort ...
After uridine-monophosphate is synthesized, it can react with 2 ATP to form uridine-triphosphate or UTP. UTP can be converted ... In order to synthesize thymidine, a component of DNA which only exists in the deoxy form, uridine is converted to deoxyuridine ... For example, the uracil base can be combined with ribose-1-phosphate to create uridine monophosphate or UMP. A similar reaction ... Thymidine synthesis first requires reduction of the uridine to deoxyuridine (see next section), before the base can be ...
Walter JH, Roberts RE, Besley GT, Wraith JE, Cleary MA, Holton JB, MacFaul R (April 1999). "Generalised uridine diphosphate ...
The enzyme nucleoside monophosphate kinase converts UMP and ATP to uridine diphosphate (UDP) and ADP. In the presence of excess ... The synthesis of deoxyuridine monophosphate (dUMP) is a multi-step process that begins with uridine monophosphate (UMP), the ... Deoxyuridine monophosphate (dUMP) is the deoxygenated form of uridine monophosphate (UMP), and is the precursor to deoxythymine ... DCMP deaminase Uridine monophosphate Berg, J. M.; Tymoczko, J. L.; Stryer, L. (2002). Biochemistry (5th ed.). New York: W H ...
Among them henna and 10% uridine ointment which went through clinical trial. Hand-foot invariably recurs with the resumption of ... Irena Netikova; Agnes Petska; Juergen Barth (2009). "Recent clinical studies with uridine cream" (PDF). EJOP. Oncology Pharmacy ... "Local treatment of hand-foot syndrome with uridine/thymidine: in vitro appraisal on a human keratinocyte cell line HaCaT". ...
... enzymic production of uridine triphosphate: uridine diphosphoglucose pyrophosphorolysis". Nature. 172 (4388): 1036-7. doi: ... Munch-Petersen A, Kalckar HM, Cutolo E, Smith EE (Dec 1953). "Uridyl transferases and the formation of uridine triphosphate; ...
When other uridine based snRNAs were knocked out, this effect was not seen. Thus, U1 snRNA-pre-mRNA base pairing was shown to ... All of these uridine-rich snRNA, with the exception of U7, form the core of the spliceosome. Splicing, or the removal of ... Lsm-class snRNAs contain a 5'-γ-monomethylphosphate cap and a 3' stem-loop, terminating in a stretch of uridines that form the ... Their nomenclature derives from their high uridine content. snRNAs were discovered by accident during a gel electrophoresis ...
Leloir LF, de Fekete MA, Cardini CE (1961). "Starch and oligosaccharide synthesis from uridine diphosphate glucose". J. Biol. ...
Pyrimidine biosynthesis Lieberman I (October 1956). "Enzymatic amination of uridine triphosphate to cytidine triphosphate". The ... glutamate It is the rate-limiting enzyme for the synthesis of cytosine nucleotides from both the de novo and uridine salvage ...
Drake JC, Hande KR, Fuller RW, Chabner BA (Mar 1980). "Cytidine and deoxycytidylate deaminase inhibition by uridine analogs". ... Cytarabine-5´-monophosphate is deaminated by deoxycytidylate deaminase, leading to the inactive uridine-5´-monophosphate analog ...
Roberts RM (August 1971). "The formation of uridine diphosphate-glucuronic acid in plants. Uridine diphosphate-glucuronic acid ... and uridine diphosphoglucuronic pyrophosphorylase. This enzyme participates in pentose and glucuronate interconversions and ...
I. Uridine diphosphate-D-glucuronic acid-5-epimerase". The Journal of Biological Chemistry. 237 (3): 638-42. doi:10.1016/S0021- ... Other names in common use include uridine diphosphoglucuronate 5'-epimerase, UDP-glucuronic acid 5'-epimerase, and C-5-uronosyl ...
KALCKAR HM, BRAGANCA B, MUNCH-PETERSEN HM (1953). "Uridyl transferases and the formation of uridine diphosphogalactose". Nature ...
Thymidine can be phosphorylated by thymidine kinase (TK). Uridine can be phosphorylated by uridine kinase (UK). Cytidine can be ...
ATP + uridine ⇌. {\displaystyle \rightleftharpoons }. ADP + UMP. Thus, the two substrates of this enzyme are ATP and uridine, ... Other names in common use include pyrimidine ribonucleoside kinase, uridine-cytidine kinase, uridine kinase (phosphorylating), ... I. Uridine-cytidine kinase of Novikoff ascites rat tumor". The Journal of Biological Chemistry. 244 (8): 2204-9. PMID 5782006. ... Skold O (1960). "Uridine kinase from Erlich ascites tumor: purification and properties". J. Biol. Chem. 235: 3273-3279.. ...
uridine 5-monophosphate (CHEBI:16695) is a uridine 5-phosphate (CHEBI:27232) uridine 5-monophosphate (CHEBI:16695) is ... uridine 5-monophosphate (CHEBI:16695) has role human metabolite (CHEBI:77746) uridine 5-monophosphate (CHEBI:16695) has role ... uridine 5-monophosphate(2−) (CHEBI:57865) is conjugate base of uridine 5-monophosphate (CHEBI:16695). UMP 3-end residue ( ... uridine 5-monophosphate residue (CHEBI:46470) is substituent group from uridine 5-monophosphate (CHEBI:16695). ...
Uridine Triacetate: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking uridine triacetate,. *tell your doctor and pharmacist if you are allergic to uridine triacetate, any other ... It is important that you take all 20 doses of uridine triacetate, even if you feel well. Do not stop taking uridine triacetate ... Take uridine triacetate exactly as directed. Do not take more or less of it or take it more often than prescribed by your ...
Uridine kinase (IPR026008). Short name: Uridine_kinase_ Overlapping homologous superfamilies *P-loop containing nucleoside ... ATP + Uridine = ADP + UMP A cDNA for uridine kinase from mouse brain was found which encodes a protein of 277 amino acids. A ... This entry represents a family of uridine kinase proteins [PMID: 19563437].. Uridine kinase (pyrimidine ribonucleoside kinase) ... Cloning and expression of a cDNA encoding uridine kinase from mouse brain.. Arch. Biochem. Biophys. 336 105-12 1996 ...
... *Formula: C21H44N2O6Si4 ... Other names: Uridine, 2,3,5,4-tetrakis(O-TMSi); Uracil ...
Uridine diphosphate definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look ... uridine diphosphate in Medicine Expand. uridine diphosphate n. Abbr. UDP A uridine compound that serves as a glycosyl carrier ...
Uridine Triacetate (Vistogard®) is a pyrimidine analog indicated for the emergency treatment of a fluorouracil or capecitabine ... About Uridine Triacetate (Vistogard®) Uridine triacetate is a pyrimidine analog. Uridine stops cell damage and cell death that ... How to Take Uridine Triacetate. The first dose of uridine triacetate should be administered within 96 hours of the end of ... Uridine triacetate s not a cancer treatment, but a supportive care medicine. This means it is used to counteract the effects of ...
Uridine (Urd) Phosphorylase catalyzes the reversible reaction, Urd + Pi⇋ uracil + ribose 1-phosphate. In cancer chemotherapy, ... Uridine (Urd) Phosphorylase catalyzes the reversible reaction, Urd + Pi ⇋ uracil + ribose 1-phosphate. In cancer chemotherapy, ... Leyva A., Kraal I., Lankelma J., Pinedo H.M. (1984) High Uridine Catabolic Activity in Cultured Human Melanoma Cells. In: De ... H. Ishitsuka, M. Miwa, K. Takemoto, K. Fukuoka, A. Itoga, and H.B. Maruyama, Role of uridine Phosphorylase for antitumor ...
... studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of uridine ...
... uridine triacetate) used to treat Hereditary Orotic Aciduria. Supplied by Wellstat Therapeutics Corporation ... FDA Approves Xuriden (uridine triacetate) to Treat Hereditary Orotic Aciduria. See Also. Xuriden (uridine triacetate) Consumer ... Xuriden (uridine triacetate) is an orally administered pyrimidine analog uridine replacement product for the treatment of ... Generic name: uridine triacetate. Dosage form: Oral Granules. Company: Wellstat Therapeutics Corporation. Treatment for: ...
I) Uridine concentrations in liver and fat depots from WT and db/db mice that were 28-31 weeks old on chow (n = 5). (J) Uridine ... C) Adipocyte Xbp1s overexpression increased plasma uridine levels (n = 5-6). Plasma uridine concentration from each mouse was ... H) Uridine concentrations in liver and fat depots from WT and ob/ob mice that were 19-23 weeks old on chow (n = 5). The ob/ob ... but not DMEM contained uridine (n = 3) (G) Concentrations of uridine in cell culture medium were elevated by Xbp1s ...
today announced a poster presentation detailing the preclinical profile of ACH-3422, a uridine-analog nucleotide prodrug being ... Achillions Uridine-Analog Nucleotide Prodrug, ACH-3422, Shows Compelling Preclinical Profile. Published 9:05 AM ET Sat, 2 Nov ... Nasdaq:ACHN) today announced a poster presentation detailing the preclinical profile of ACH-3422, a uridine-analog nucleotide ... The poster presentation, entitled, "Preclinical Characteristics of ACH-3422: A Potent Uridine Nucleotide Prodrug for Inhibition ...
URIDINE-5-DIPHOSPHATE. C9 H14 N2 O12 P2. XCCTYIAWTASOJW-XVFCMESISA-N. Ligand Interaction. ... Inhibitor design to Ribonuclease A: The binding of two 5phosphate uridine analogues. Tsirkone, V.G., Dossi, K., Drakou, C., ...
Uridine. PDB Entries. 1i5l / 1lnx / 1loj / 1tlz / 2fr6 / 2hwu / 2v0l / 3ivd / 3tij / 4eg2 … ... Uridine. Accession Number. DB02745 (EXPT03205) Type. Small Molecule. Groups. Experimental, Investigational. Description. Not ... Hidetoshi Yoshioka, Eiji Kojima, Shuji Ishida, Hiroyuki Yoshioka, Kunichika Murakami, 2,3-dideoxy-4-thio-uridine derivatives ...
Uridine ≥99%; CAS Number: 58-96-8; EC Number: 200-407-5; Synonym: 1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside; ... Uridine is present in blood, seminal fluid and cerebrospinal fluid. Uridine is synthesized in living organisms by de novo and ... Oral administration of uridine is suggested for anisopoikilocytosis and epileptic encephalopathy disorders. Uridine has ... Uridine ≥99% Synonym: 1-β-. D. -Ribofuranosyluracil, Uracil-1-β-. D. -ribofuranoside ...
Uridine, 2,3,5-tris-O-acetyl. *Formula: C15H18N2O9 ...
Contrasting short-term and long-term consequences of uridine on liver metabolism suggest that uridine exerts transient effects ... Uridine affects liver protein glycosylation, insulin signaling, and heme biosynthesis.. Urasaki Y1, Pizzorno G1, Le TT1. ... Short-term uridine administration is also associated with reduced liver hemin level and reduced ability for insulin-stimulated ... Some of the short-term effects of exogenous uridine in C57BL/6J mice are conserved in transgenic UPase1-/- mice with long-term ...
... Takayuki Matsumoto,1,2 Rita C. Tostes,3 and R. Clinton ... The dinucleotide uridine adenosine tetraphosphate (Up4A) (Figure 1) was identified by Jankowski et al. [14] as a novel potent ... Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting ... A. E. Linder, M. Tumbri, F. F. Linder, R. C. Webb, and R. Leite, "Uridine adenosine tetraphosphate induces contraction and ...
Uridine also supports the health and function of liver mitochondria.* Keep out of the reach of children. ... Uridine is a nucleotide that acts as a precursor neededin conjunction with the omega-3 fatty acid docosahexaenoic acid (DHA) ... What Does Uridine Do? Uridine is a nucleotide that acts as a precursor needed--in conjunction with the omega-3 fatty acid ... Uridine also supports the health and function of liver mitochondria.* ...
Uridine is a nucleotide that acts as a precursor needed - in conjunction with the omega-3 fatty acid docosahexaenoic acid (DHA ...
Upon digestion of foods containing RNA, uridine is released from RNA and is absorbed intact in the gut. Uridine plays a role in ... Uridine is one of the four basic components of ribonucleic acid (RNA); the other three are adenosine, guanosine, and cytidine. ... Upon digestion of foods containing RNA, uridine is released from RNA and is absorbed intact in the gut. Uridine plays a role in ... Uridine is one of the four basic components of ribonucleic acid (RNA); the other three are adenosine, guanosine, and cytidine. ...
Buy our Recombinant mycobacterium tuberculosis Uridine Phosphorylase protein. Ab73763 is an active full length protein produced ... Uridine Phosphorylase belongs to the PNP/UDP phosphorylase family. It catalyzes the reversible phosphorylytic cleavage of ... uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon ...
Uridine diphosphate glucose pyrophosphatase. A, C [auth B], B [auth C], D. 218. Homo sapiens. Mutation(s): 0 Gene Names: NUDT14 ... Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14). Tresaugues, L., Siponen, M.I., Arrowsmith, C.H ... Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14). *DOI: 10.2210/pdb3Q91/pdb ...
Uridine kinase activity. Specific Function. Phosphorylates uridine and cytidine to uridine monophosphate and cytidine ... Uridine monophosphokinase 2. Gene Name. UCK2. Organism. Humans. Amino acid sequence. ,lcl,BSEQ0002938,Uridine-cytidine kinase 2 ... Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59(5 ... Uridine 5-triphosphate. experimental, investigational. unknown. Details. DB04272. Citric acid. approved, nutraceutical, vet_ ...
Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5- ... Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. ... Uridine phosphorylase (UPP2), Uridine phosphorylase (UPP2), Uridine phosphorylase 1 (UPP1), Uridine phosphorylase 2 (UPP2) ... Uridine phosphorylase 2Add BLAST. 317. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical view. ...
The factor was identified as uridine. Uridine may act as a morphogen in plant roots at picomolar concentrations. ... Uridine, a Cell Division Factor in Pea Roots Plant Mol Biol. 1995 Nov;29(4):869-73. doi: 10.1007/BF00041176. ...
Uridine , C9H12N2O6 , CID 6029 - structure, chemical names, physical and chemical properties, classification, patents, ...
It is an ester of phosphoric acid with the nucleoside uridine. UMP consists of the phosphate group, the pentose sugar ribose, ... Template:Chembox new Uridine monophosphate, also known as 5-uridylic acid and abbreviated UMP, is a nucleotide that is found ... Uridine monophosphate is formed from orotidylic acid in a decarboxylation reaction catalyzed by the enzyme orotidylate ... Retrieved from "https://www.wikidoc.org/index.php?title=Uridine_monophosphate&oldid=727864" ...
Oral Uridine for Treatment of Bipolar Depression in Adolescents. Official Title ICMJE Oral Administration of Uridine for ... Uridine is a naturally occurring chemical that is made by the human liver. Uridine is part of a family of compounds called ... Drug: Uridine Uridine 500 mg by mouth twice per day for 6 weeks ... Experimental: Uridine Uridine 500 mg by mouth twice daily for 6 ... Uridine is considered experimental, because it has not been approved by the U.S. Food and Drug Administration (FDA) to treat ...
uridine/aquamed/sculptra. Apr 2, 2006 Ive had a number of treaments with Sculptra to the face, with reasonable success. Is ... Also, whats the final word on Uridine? Does it help, or is it expensive snake oil, and if it works, how do I get it? Thanks - ... I have seen no information on its use in the buttock ( a large amount would be needed there compared to the face). Uridine is ...
  • Up 4 A is released from the endothelium in response to acetylcholine (ACh), the calcium ionophore (A23187), endothelin-1, adenosine triphosphate (ATP), uridine triphosphate (UTP), and mechanical stress. (hindawi.com)
  • Combination therapy using nebulized amiloride hydrochloride and uridine-5'-triphosphate (UTP) trisodium salt aerosols has been investigated for the treatment of cystic fibrosis (CF). Amiloride in aqueous solution precipitates in the presence of UTP, reducing drug concentrations. (rti.org)
  • Uridine triphosphate (UTP) nucleotide molecule. (sciencephoto.com)
  • We previously showed that supplementing PC12 cells with uridine caused concentration-related increases in CDP-choline levels, and that this effect was mediated by elevations in intracellular uridine triphosphate (UTP) and cytidine triphosphate (CTP). (rug.nl)
  • we sell pharmaceutical intermediates of uridine triphosphate trisodium (CAS 63-39-8). (trader-china.com)
  • Our company is specialized exporter, manufacturer and supplier of Uridine triphosphate trisodium in china. (trader-china.com)
  • Uridine 5'-(tetrahydrogen triphosphate). (hmdb.ca)
  • Uridine triphosphate has the role of a source of energy or an activator of substrates in metabolic reactions, like that of adenosine triphosphate, but more specific. (hmdb.ca)
  • When Uridine triphosphate activates a substrate, UDP-substrate is usually formed and inorganic phosphate is released. (hmdb.ca)
  • Secretion of ATP from Schwann cells in response to uridine triphosphate. (longecity.org)
  • Uridine 5' triphosphate (UTP) is a pyrimidine nucleotide which is released from a variety of cells including platelets and endothelial cells. (bl.uk)
  • However, only a few studies have focused on the effect of pyrimidines, such as uridine triphosphate (UTP) and uridine diphosphate (UDP), in the heart. (ahajournals.org)
  • Uridine is widely produced in nature as uridine monophosphate (uridylate) by de novo synthesis by the decarboxylation of orotidylate, which is catalyzed by orotidylate decarboxylase. (wikipedia.org)
  • In infants consuming mother's milk or commercial infant formulas, uridine is present as its monophosphate, UMP, which is both bioavailable and able to enter the circulation from the digestive tract. (wikipedia.org)
  • Deoxyuridine monophosphate Uridine monophosphate International Union of Pure and Applied Chemistry (2014). (wikipedia.org)
  • Uridine monophosphate synthase (UMPS) (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) is the enzyme that catalyses the formation of uridine monophosphate (UMP), an energy-carrying molecule in many important biosynthetic pathways. (wikipedia.org)
  • These two sites catalyze the last two steps of the de novo uridine monophosphate (UMP) biosynthetic pathway. (wikipedia.org)
  • After addition of ribose-P to orotate by OPRTase to form orotidine-5'-monophosphate (OMP), OMP is decarboxylated to form uridine monophosphate by ODCase. (wikipedia.org)
  • In microorganisms, these two domains are separate proteins, but, in multicellular eukaryotes, the two catalytic sites are expressed on a single protein, uridine monophosphate synthase. (wikipedia.org)
  • Uridine monophosphate is essential for protein glycosylation, polysaccharide biosynthesis and lipid metabolism. (sigmaaldrich.com)
  • Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. (drugbank.ca)
  • Template:Chembox new Uridine monophosphate , also known as 5'-uridylic acid and abbreviated UMP , is a nucleotide that is found in RNA . (wikidoc.org)
  • Uridine monophosphate is formed from orotidylic acid in a decarboxylation reaction catalyzed by the enzyme orotidylate decarboxylase . (wikidoc.org)
  • The present invention relates also to a drug combination comprising free fatty acids and/or fatty acid esters and uridine, deoxyuridine, uridine monophosphate and/or deoxyuridine monophosphate, and to the use of such a drug combination. (patentgenius.com)
  • We examined the biochemical pathways whereby oral uridine-5'-monophosphate (UMP) increases membrane phosphatide synthesis in brains of gerbils. (rug.nl)
  • We offer Uridine monophosphate disodium (CAS: 3387-36-8). (trader-china.com)
  • Supplementing a choline-containing diet with the uridine source uridine-5'-monophosphate (UMP) or, especially, with UMP plus the omega-3 fatty acid docosahexaenoic acid (given by gavage), produces substantial increases in membrane phosphatide and synaptic protein levels within gerbil brain. (longecity.org)
  • Uridine is a uracil nucleoside, specific for RNA sequence. (sigmaaldrich.com)
  • In this study, the roles of uridine, a pyrimidine nucleoside, in liver metabolism are examined in mice. (nih.gov)
  • Van Rompay AR, Norda A, Linden K, Johansson M, Karlsson A: Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. (drugbank.ca)
  • Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates. (uniprot.org)
  • It is an ester of phosphoric acid with the nucleoside uridine . (wikidoc.org)
  • The nucleoside uridine is well known for its role in critical cellular functions such as nucleic acid synthesis. (sciencemag.org)
  • Uridine is a pyrimidine nucleoside that is critical for cellular function and survival. (sciencemag.org)
  • Uridine diphosphategalactose (UDPgal) is a nucleoside diphosphate sugar which can be epimerized into UDPglucose for entry into the mainstream of carbohydrate metabolism. (hmdb.ca)
  • We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. (lu.se)
  • article{416ac1b3-c842-40fa-8d2e-8ca4d0d2088d, abstract = {We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. (lu.se)
  • Uridine diphosphate glucose-sterol glucosyltransferase and nucleoside diphosphatase activities in etiolated pea seedlings. (semanticscholar.org)
  • Uridine (Urd) is the most commonly modified nucleoside among those that occur naturally, but has also been an important target for synthesis and development of modified nucleosides for pharmaceutical applications. (illinois.edu)
  • Uridine is a therapy for hereditary orotic aciduria and is being investigated in other disorders caused by mitochondrial dysfunction, including toxicities resulting from treatment with nucleoside reverse transcriptase inhibitors in HIV. (nih.gov)
  • At baseline (t = 0 on Day 1), mean plasma uridine level was 4.7 uM, consistent with known physiologic concentrations of this nucleoside [2]. (nih.gov)
  • Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a β-N1-glycosidic bond. (wikipedia.org)
  • In enzymology, an uridine phosphorylase (EC 2.4.2.3) is an enzyme that catalyzes the chemical reaction uridine + phosphate ⇌ {\displaystyle \rightleftharpoons } uracil + alpha-D-ribose 1-phosphate Thus, the two substrates of this enzyme are uridine and phosphate, whereas its two products are uracil and alpha-D-ribose 1-phosphate. (wikipedia.org)
  • Uridine (Urd) Phosphorylase catalyzes the reversible reaction, Urd + P i ⇋ uracil + ribose 1-phosphate. (springer.com)
  • It catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. (abcam.com)
  • Application of [ 14 C]Uridine can be found in: pyrimidine salvage and catabolism in mangrove species in plant science research, long-term effect of NaCl on the activity of uridine and uracil salvage for nucleotide synthesis in plant science research, glutathione-induced growth of embryogenic tissue of white spruce correlating with changes in pyrimidine nucleotide metabolism in plant science research, etc. (perkinelmer.com)
  • plasma uridine levels rose 1.8 fold 30 minutes after beer ingestion, suggesting, at the very least, conflicting data. (wikipedia.org)
  • In mammals, plasma uridine levels are tightly regulated, but the underlying mechanisms are unclear. (sciencemag.org)
  • show that plasma uridine levels are controlled by feeding behavior (see the Perspective by Jastroch and Tschöp). (sciencemag.org)
  • Plasma uridine levels are maintained within a narrow range, and most cells depend on a readily available pool of uridine in plasma to maintain basic cellular functions. (sciencemag.org)
  • Studying rodent models, we set out to define the mechanisms regulating plasma uridine levels and to dissect the molecular circuitry whereby uridine governs energy homeostasis in normal and obese conditions. (sciencemag.org)
  • Plasma uridine levels at t = 0 as well as mean uridine area under the curve (AUC) and AUC∞ were greater on Day 7 than on Day 1, but the latter could be attributed to the higher baseline level of uridine on Day 7. (nih.gov)
  • When plasma uridine levels were adjusted for body weight or lean body mass, the differences between men and women were no longer evident. (nih.gov)
  • Among the men, plasma uridine levels were higher on Day 7 compared with Day 1 at all time points (Figure 3a), but among the women, there were no significant differences in the PK profiles on days 1 and 7 (Figure 3b). (nih.gov)
  • This chapter provides the diffusion coefficient of uridine 5-(trihydrogen diphosphate) P-a-D- glucopyranosyl ester in dideuterium oxide at infinite dilution for various temperature and pressure conditions measured using NMR spin echo pulse gradient. (springer.com)
  • Here we have examined the regulatory role Xbp1s in stimulation of uridine biosynthesis in adipocytes and triglyceride mobilization using inducible mouse models. (nih.gov)
  • Xbp1s is a key molecule involved in adipocyte uridine biosynthesis and release by activation of carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, dihydroorotase (CAD), the rate-limiting enzyme for UMP biosynthesis. (nih.gov)
  • Uridine affects liver protein glycosylation, insulin signaling, and heme biosynthesis. (nih.gov)
  • Evaluation of the effects of uridine on liver heme biosynthesis and insulin signaling activity. (nih.gov)
  • In addition to its role in RNA and DNA biosynthesis, uridine is required for glycogen deposition, protein and lipid glycosylation, extracellular matrix biosynthesis, and detoxification of xenobiotics. (sciencemag.org)
  • The catabolic activity of Urd Phosphorylase is required for the activity of 5′-deoxy-5-fluoro-uridine which cannot be phosphorylated by kinases and must first be cleaved to 5-fluorouracil 2,3 . (springer.com)
  • Uridine Phosphorylase belongs to the PNP/UDP phosphorylase family. (abcam.com)
  • A truncated form of the cDNA was expressed in Escherichia coli, and shown to display uridine kinase activity and to readily form a tetramer, the most active form of the wild-type enzyme. (ebi.ac.uk)
  • Uridine is synthesized in living organisms by de novo and salvage pathways. (sigmaaldrich.com)
  • Therefore, inhibition of influenza A virus infection by conjugates of uridine and 2-deoxy sugars is a new promising approach for the development of new derivatives with anti-influenza activities. (mdpi.com)
  • In the protection studies, 100 microM thymidine almost completely antagonized the inhibition of granulocyte-macrophage colony formation produced by 1 microM AZT (50% inhibitory concentration), and 50 microM uridine effected 60% protection against a toxic concentration of AZT (5 microM) (70% inhibitory concentration). (asm.org)
  • The present invention relates to novel uridine esters of the general formula ##STR00001## wherein R represents a carboxylic acid residue, preferably a fatty acid residue and R' represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. (patentgenius.com)
  • The present invention relates to novel uridine esters, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters andpharmaceutical compositions containing at least one uridine ester as active ingredient. (patentgenius.com)
  • Uridine-5'-diphospho-α-D-galactose disodium salt (CAS 137868-52-1) Market Research Report 2018 aims at providing comprehensive data on uridine-5'-diphospho-α-d-galactose disodium salt market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
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  • Uridine-5'-diphospho-α-D-galactose disodium salt (CAS 137868-52-1) Market Research Report 2018 contents were prepared and placed on the website in February, 2018. (marketpublishers.com)
  • Please note that Uridine-5'-diphospho-α-D-galactose disodium salt (CAS 137868-52-1) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • A cDNA for uridine kinase from mouse brain was found which encodes a protein of 277 amino acids. (ebi.ac.uk)
  • We report that short-term uridine administration in C57BL/6J mice increases liver protein glycosylation profiles, reduces phosphorylation level of insulin signaling proteins, and activates the HRI-eIF-2α-ATF4 heme-deficiency stress response pathway. (nih.gov)
  • Uridine supplementation increases liver glycogen content and protein O-linked glycosylation profiles. (nih.gov)
  • C ) Enlarged 2D Western blot areas to highlight the effects of uridine on O-linked glycosylation profiles of protein spots 9, 10, and 30. (nih.gov)
  • Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils.Cansev M, Wurtman RJ. (longecity.org)
  • We observed that protein expression of enzymes that modify wobble uridine in specific tRNAs, namely elongator subunit 3 (Elp3) and cytosolic thiouridylase (Ctu)2, increased in the course of T cell activation. (jimmunol.org)
  • Pyrimidine nucleosides are a type of non-protein nitrogenous compounds that contain cytidine and uridine, they said. (feednavigator.com)
  • Once the incoming galactose has been converted into galactose 1-phosphate (Gal-1-P), it is involved in a reaction with UDP-glucose, a glucose molecule bonded to uridine diphosphate (UDP). (wikipedia.org)
  • Toxin ζ expression triggers a reversible state of dormancy, diminishes the pool of purine nucleotides, promotes (p)ppGpp synthesis, phosphorylates a fraction of the peptidoglycan precursor uridine diphosphate-N-acetylglucosamine (UNAG), leading to unreactive UNAG-P, induces persistence in a reduced subpopulation, and sensitizes cells to different antibiotics. (mdpi.com)
  • Functional groups of 'universal' uridine-33 in yeast tRNA('Phe) were altered by a synthetic procedure which replaces U-33 with any desired nucleotide and leaves all other nucleotides of the tRNA intact. (illinois.edu)
  • This enzyme, the product of the YML014w gene, catalyzes the esterification of modified uridine nucleotides, resulting in the formation of 5-methylcarbonylmethyluridine in tRNA Arg3 and 5-methylcarbonylmethyl-2-thiouridine in tRNA Glu . (asm.org)
  • Three members of the P2Y receptor subfamily, the P2Y 2 , P2Y 4 , and P2Y 6 receptors, are potently stimulated by uridine nucleotides. (aspetjournals.org)
  • Extracellular uridine nucleotides regulate several components of airway epithelial mucociliary clearance. (aspetjournals.org)
  • This entry represents a family of uridine kinase proteins [ PMID: 19563437 ]. (ebi.ac.uk)
  • The predicted secondary structure, and sequence comparison with kinases of known structure, is consistent with uridine kinase having the alpha/beta core nucleotide-binding fold common to many kinases [ PMID: 8951040 ]. (ebi.ac.uk)
  • We have previously shown that two 2-deoxy sugar derivatives of uridine (designated IW3 and IW7) targeting the glycan processing steps during maturation of viral glycoproteins show good anti-influenza virus activity and may be a promising alternative approach for the development of new anti-influenza therapy. (mdpi.com)
  • Nucleosides like adenosine, uridine and their nucleotide derivatives (e.g. (diva-portal.org)
  • suffix for uridine derivatives used as antiviral agents and as antineoplastics. (thefreedictionary.com)
  • Take uridine triacetate at around the same times every day. (medlineplus.gov)
  • Take uridine triacetate exactly as directed. (medlineplus.gov)
  • Do not take uridine triacetate if you are allergic to uridine triacetate or any of its ingredients. (rxwiki.com)
  • Do not stop taking uridine triacetate without talking to your doctor. (medlineplus.gov)
  • If you become pregnant while taking uridine triacetate, call your doctor. (medlineplus.gov)
  • Keep in mind that many of the side effects you will be experiencing while taking uridine triacetate may be side effects of the fluorouracil or capecitabine previously received, and not the uridine triacetate. (oncolink.org)
  • Before taking uridine triacetate, tell your doctor about all of your medical conditions. (rxwiki.com)
  • Uridine plays a role in the glycolysis pathway of galactose. (wikipedia.org)
  • UDPgal is a product of the galactose-l-phosphate uridyl transferase (EC 2.7.7.10) reaction but may also be made from Glucose-l-P, involving uridine diphosphate galactose-4-epimerase (EC 5.1.3.2). (hmdb.ca)
  • Uridine is a nucleotide that acts as a precursor needed--in conjunction with the omega-3 fatty acid docosahexaenoic acid (DHA) and the B vitamin-like compound choline-for the synthesis of membrane phospholipids and brain synapses. (jarrow.com)
  • These results show that oral UMP, a uridine source, enhances the synthesis of CDP-choline, the immediate precursor of PC, in gerbil brain. (rug.nl)
  • Uridine is a nucleotide that acts as a precursor of brain synapses and membrane phospholipids in conjunction with the omega-3 fatty acid docosahexaenoic acid (DHA) and choline sources. (smithsfoodanddrug.com)
  • Uridine has been shown to work synergistically with choline and other nootropic substances to boost overall cognition, significantly increasing alertness and focus. (forresthealth.com)
  • Aging human subjects who received uridine in combination with choline, vinpocetine, and other cognitive enhancers demonstrated improvement in short-term memory, recognition, recall, and executive function. (forresthealth.com)
  • Choline + Uridine: Build New Neurons and Protect Against Alzheimer's! (smart-publications.com)
  • However, this inevitable decline in brainpower is not inevitable thanks to two naturally occurring compounds in your body-choline (one of the B vitamins) and uridine (a building block of RNA)-and a fascinating, naturally occurring self-maintenance system going on in your brain right now .The trick is to support this natural self-maintenance system by "feeding" it properly. (smart-publications.com)
  • So how important are choline and uridine to your brain's self-maintenance system? (smart-publications.com)
  • Combination of Omega3s + choline + uridine is believed to be an effective dietary intervation for Alzheimer patients. (longecity.org)
  • It looks like Citicoline may theoretically be better for cognitive decline/brain repair then alpha GPC if based on the Omega 3+Uridine+Choline combo theory. (longecity.org)
  • Despite its pivotal physiological role, uridine has received limited attention in comparison to other nucleosides such as adenosine. (sciencemag.org)
  • A food supplement containing nucleosides, NucleomaxX®, has been reported to raise plasma uridine to supraphysiologic levels. (nih.gov)
  • Xuriden (uridine triacetate) is an orally administered pyrimidine analog uridine replacement product for the treatment of patients with hereditary orotic aciduria. (drugs.com)
  • Hereditary orotic aciduria is a rare autosomal recessive disorder caused by a defective or deficient enzyme resulting in the body being unable to normally synthesize uridine, a necessary component of ribonucleic acid (RNA). (drugs.com)
  • Uridine triacetate is a prescription medication used to treat hereditary orotic aciduria, a rare metabolic disorder in which the body can not make uridine. (rxwiki.com)
  • When treating hereditary orotic aciduria, this medication works by replacing uridine. (rxwiki.com)
  • Other names in common use include pyrimidine ribonucleoside kinase , uridine-cytidine kinase , uridine kinase (phosphorylating) , and uridine phosphokinase . (wikipedia.org)
  • Uridine kinase (pyrimidine ribonucleoside kinase) is the rate-limiting enzyme in the pyrimidine salvage pathway. (ebi.ac.uk)
  • Other names in common use include pyrimidine ribonucleoside kinase, uridine-cytidine kinase, uridine kinase, and uridine phosphokinase. (definitions.net)
  • Cloning and expression of a cDNA encoding uridine kinase from mouse brain. (ebi.ac.uk)
  • Koizumi K, Shimamoto Y, Azuma A, Wataya Y, Matsuda A, Sasaki T, Fukushima M: Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells. (drugbank.ca)
  • A cDNA clone, designated UGT2B7 variant, encoding a 529-amino acid human liver microsomal uridine diphosphate-glucuronosyltransferase (UGT) was isolated from a lambda gt11 human liver cDNA library. (aspetjournals.org)
  • The deduced amino sequence of UGT2B7 variant was shown to differ only in one amino acid (tyrosine for histidine at position 268) from a previously published uridine diphosphate-glucuronosyltransferase cDNA, UGT2B7. (aspetjournals.org)
  • Thus, the two substrates of this enzyme are ATP and uridine , whereas its two products are ADP and UMP . (wikipedia.org)
  • The systematic name of this enzyme class is ATP:uridine 5'-phosphotransferase . (wikipedia.org)
  • The systematic name of this enzyme class is uridine:phosphate alpha-D-ribosyltransferase. (wikipedia.org)
  • In enzymology, an uridine kinase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and uridine, whereas its two products are ADP and UMP. (definitions.net)
  • An enzyme that catalyzes the phosphorylation of uridine and cytidine to uridine 5'-phosphate and cytidine 5'-phosphate, respectively. (definitions.net)
  • Uridine-cytidine kinase-like 1 is an enzyme that in humans is encoded by the UCKL1 gene. (wikipedia.org)
  • A uridine compound that serves as a glycosyl carrier in the synthesis of glycogen and starch. (dictionary.com)
  • Lipolysis is stimulated by fasting when uridine synthesis is also activated in adipocytes. (nih.gov)
  • Crude extracts of Mycobacterium smegmatis catalyzed the synthesis of adenosine diphosphate-glucose (ADP-Glc), cytidine diphosphate-glucose, guanosine diphosphate-glucose (GDP-Glc), thymidine diphosphate-glucose (TDP-Glc), and uridine diphosphate-glucose (UDP-Glc). (asm.org)
  • Highly stereoselective palladium‐catalyzed Heck coupling of 5‐iodo‐uridine‐5′‐triphosphates with allylamine: A new efficient method for the synthesis of (E)‐5‐aminoallyl‐uridine‐5′‐triphosphates. (currentprotocols.com)
  • I dont remember reading the level of uridine it increases, but the way he expresses it, it seems this its significant. (longecity.org)
  • Evaluation of the effects of uridine on ER stress and regulation of eIF-2α. (nih.gov)
  • Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats. (longecity.org)
  • The team found that adding a combination of cytidine and uridine to broiler diets could improve some performance factors for broilers, they said. (feednavigator.com)
  • The diets included a corn-soybean meal control diet, the control diet with 0.1% pure uridine, the control diet with 0.1% pure cytidine and the diet with 0.1% of a uridine and cytidine combination, they said. (feednavigator.com)
  • Single and repeated dosing with NucleomaxX® resulted in peak plasma uridine concentrations 1-2 hours later of 150.9 ± 39.3 µM and 161.4 ± 31.5 µM, respectively, levels known to ameliorate mitochondrial toxicity in vitro.No adverse effects of either treatment were observed.NucleomaxX®, containing predominantly TAU, has significantly greater bioavailability than pure uridine in human subjects and may be useful in the management of mitochondrial toxicity. (nih.gov)
  • Single- and multi-dose PK studies following NucleomaxX® were compared to single-dose PK studies of equimolar doses of pure uridine in healthy human volunteers. (nih.gov)
  • NucleomaxX®, containing predominantly TAU, has significantly greater bioavailability than pure uridine in human subjects and may be useful in the management of mitochondrial toxicity. (nih.gov)
  • Supplementation of the two surviving children with oral uridine led to immediate cessation of seizures in both. (ru.nl)
  • Uridine triacetate comes as granules to take by mouth. (medlineplus.gov)
  • Uridine triacetate comes in a granule form, to be taken every 6 hours for 20 doses. (oncolink.org)
  • NEW HAVEN, Conn., Nov. 2, 2013 (GLOBE NEWSWIRE) -- Achillion Pharmaceuticals, Inc. (Nasdaq:ACHN) today announced a poster presentation detailing the preclinical profile of ACH-3422, a uridine-analog nucleotide prodrug being advanced for the potential treatment of chronic hepatitis C viral infection (HCV). (cnbc.com)
  • Uridine triacetate is used for the emergency treatment of children and adults who have either received too much of chemotherapy medications such as fluorouracil or capecitabine (Xeloda) or who develop certain severe or life-threatening toxicities within 4 days of receiving fluorouracil or capecitabine. (medlineplus.gov)
  • However, thymidine is more commonly written as 'dT' ('d' represents 'deoxy') as it contains a 2'-deoxyribofuranose moiety rather than the ribofuranose ring found in uridine. (wikipedia.org)
  • The antiretroviral activity of AZT in human peripheral blood mononuclear cells, assessed by revere transcriptase assays, was substantially decreased in the presence of thymidine, whereas no impairment of suppression of viral replication was observed in the presence of uridine in combination with AZT at a molar ratio (uridine/AZT) as high as 10,000. (asm.org)
  • Oral administration of uridine is suggested for anisopoikilocytosis and epileptic encephalopathy disorders. (sigmaaldrich.com)
  • Nutrient sensing in mammals is done through the hexosamine biosynthetic pathway (HSP), which produces uridine 5'-diphospho-N-acetylglucosamine (UDP-Glc-NAc) as its end product. (hmdb.ca)
  • Adenine-uridine rich elements (AREs) play an important role in modulating mRNA stability, being the target site of many ARE-binding proteins (AUBPs) that are involved in the decay process. (aspetjournals.org)
  • Harvard researchers report that omega-3 fatty acids and uridine, two substances in foods such as fish, walnuts, molasses, and sugar beets, prevented depression in rats as effectively as antidepressant drugs. (wikipedia.org)
  • Uridine triacetate belongs to a group of drugs called pyrimidine analogs. (rxwiki.com)
  • Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. (aspetjournals.org)
  • On the other hand, ethanol on its own (which is present in beer) increases uridine levels, which may explain the raise of uridine levels in the study by Yamamoto et al. (wikipedia.org)
  • Citicoline apparently not only increases cytidine, but Uridine as well. (longecity.org)
  • The only supplement available on the market that increases uridine is Nucleomaxx[B], and it does it at very high levels. (longecity.org)
  • Characterization of Sucrolysis via the Uridine Diphosphate and Pyrophosphate-Dependent Sucrose Synthase Pathway. (semanticscholar.org)
  • The purpose of the study is to see if the investigational medication uridine reduces depression symptoms in adolescents with bipolar disorder. (clinicaltrials.gov)
  • This is an open-label study of the investigational drug uridine in the treatment of adolescents with depression with bipolar disorder. (clinicaltrials.gov)
  • Uridine has shown positive results in a Phase II study of bipolar disorder in adults (http://clinicaltrials.gov/ct2/show/NCT00322764). (clinicaltrials.gov)
  • citation needed] goat's and sheep's milk and milk products Sugarcane extract Tomatoes (0.5 to 1.0 g uridine per kilogram dry weight)[verification needed] Brewer's yeast (1.7% uridine by dry weight) Beer Broccoli Organ meats (liver, pancreas, etc. (wikipedia.org)
  • Short-term uridine administration is also associated with reduced liver hemin level and reduced ability for insulin-stimulated blood glucose removal during an insulin tolerance test. (nih.gov)
  • Contrasting short-term and long-term consequences of uridine on liver metabolism suggest that uridine exerts transient effects and elicits adaptive responses. (nih.gov)
  • A ) Liver glycogen as a function of dietary uridine supplementation. (nih.gov)
  • Uridine also supports the health and function of liver mitochondria. (jarrow.com)
  • Uridine is a naturally occurring chemical that is made by the human liver. (clinicaltrials.gov)
  • Target sizes of galactosyltransferase, sialyltransferase, and uridine diphosphatase in Golgi apparatus of rat liver. (semanticscholar.org)