A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
A biochemical abnormality referring to an elevation of BLOOD UREA NITROGEN and CREATININE. Azotemia can be produced by KIDNEY DISEASES or other extrarenal disorders. When azotemia becomes associated with a constellation of clinical signs, it is termed UREMIA.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Excision of kidney.
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urinary tract obstruction, or unilateral ureteral obstruction when a solitary kidney is present.
Devices which can substitute for normally functioning KIDNEYS in removing components from the blood by DIALYSIS that are normally eliminated in the URINE.
Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.
Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).
Dialysis fluid being introduced into and removed from the peritoneal cavity as either a continuous or an intermittent procedure.
Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.
Duration of blood flow after skin puncture. This test is used as a measure of capillary and platelet function.
The bones of the upper and lower ARM. They include the CLAVICLE and SCAPULA.
Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.
Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Mechanical food dispensing machines.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Activities performed in the preparation of bibliographic records for CATALOGS. It is carried out according to a set of rules and contains information enabling the user to know what is available and where items can be found.
An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.
An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Glucose in blood.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
Substances that inhibit or arrest DENTAL CARIES formation. (Boucher's Clinical Dental Terminology, 4th ed)
A chronic endemic form of hypoplasia of the dental enamel caused by drinking water with a high fluorine content during the time of tooth formation, and characterized by defective calcification that gives a white chalky appearance to the enamel, which gradually undergoes brown discoloration. (Jablonski's Dictionary of Dentistry, 1992, p286)
Electrodes which can be used to measure the concentration of particular ions in cells, tissues, or solutions.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A publication issued at stated, more or less regular, intervals.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.

Mechanism of parathyroid tumourigenesis in uraemia. (1/1382)

Clonal analysis has shown that in renal hyperparathyroidism (2-HPT), parathyroid glands initially grow diffusely and polyclonally after which the foci of nodular hyperplasia are transformed to monoclonal neoplasia. There is a great deal of information about genetic abnormalities contributing to the tumourigenesis of parathyroid neoplasia in primary hyperparathyroidism. It is speculated that allelic loss of the MEN1 suppressor gene and overexpression of cyclin D1 induced by rearrangement of the parathyroid hormone gene may be the major genetic abnormality in sporadic parathyroid adenoma but not in 2-HPT. The pathogenesis of 2-HPT, abnormality of the Ca2+-sensing receptor (CaR) gene and the vitamin D receptor gene may possibly contribute to parathyroid tumourigenesis in 2-HPT. However, this is not yet clear and heterogeneous and multiple genetic abnormalities may be responsible for the progression of secondary parathyroid hyperplasia.  (+info)

Implication of carbonyl stress in long-term uraemic complications. (2/1382)

Advanced glycation end products (AGEs) are formed during non-enzymatic glycation and oxidation (glycoxidation) reactions. AGEs, such as pentosidine and carboxymethyllysine are increased in plasma proteins and skin collagen of uraemic patients several times more than in normal subjects and non-uraemic diabetic patients. However, AGEs do not differ between diabetics and non-diabetics in uraemic patients. The AGE accumulation in uraemia, therefore, cannot be attributed to hyperglycaemia, nor simply to a decreased removal by glomerular filtration of AGE-modified proteins. Recent evidence has suggested that, in uraemia, the increased carbonyl compounds, derived from both carbohydrates and lipids, modify proteins not only by glycoxidation but also by lipoxidation reactions, leading to the increased production of AGEs and advanced lipoxidation end products (ALEs). Thus, uraemia might be a state of increased carbonyl compounds with potentially damaging proteins ('carbonyl stress'). Carbonyl stress in uraemia appears relevant to long-term complications, such as dialysis-related amyloidosis. The increased AGEs and ALEs in uraemic plasma and tissue proteins may indicate alterations in the non-enzymatic chemistry involving both carbohydrates and lipids in uraemia.  (+info)

Maintenance of normal agonist-induced endothelium-dependent relaxation in uraemic and hypertensive resistance vessels. (3/1382)

BACKGROUND: The nitric oxide system has been implicated in several diseases with vascular complications including diabetes mellitus and hypertension. Despite the high prevalence of hypertension and cardiovascular complications in renal failure few studies have examined vascular and endothelial function in uraemia. We therefore chose to study possible abnormalities of the nitric oxide vasodilator system in an animal model of chronic renal failure. METHODS: Adult spontaneous hypertensive rats and Wistar Kyoto rats were subjected to a 5/6 nephrectomy with control animals having sham operations. After 4 weeks blood pressure was recorded and the animals were sacrificed. Branches of the mesenteric arteries were isolated and mounted on a Mulvany myograph. All experiments were performed in the presence of indomethacin (10(-5) M). The vessels were first preconstricted with noradrenaline, exposed to increasing concentrations of acetylcholine (10(-8) to 10(-4) M) and subsequently to sodium nitroprusside (10(-5) M). RESULTS: There was no difference in the relaxation of the four groups of vessels to any of the concentrations of acetylcholine used nor was there any significant difference in the EC50s (control Wistar Kyoto 6.1+/-1.4 x 10(-8) M; uraemic Wistar Kyoto 5.4+/-0.8 x 10(-8) M; control spontaneous hypertensive rats 4.5+/-0.6 x 10(-8) M; uraemic spontaneous hypertensive rats 6+/-0.7 x 10(-8) M). Vasodilatation in response to sodium nitroprusside was unchanged in uraemic vessels. In addition the vascular responses to both acetylcholine and sodium nitroprusside were unaltered in spontaneous hypertensive rats. CONCLUSIONS: We conclude that normal agonist-induced endothelium-dependent relaxation is maintained in experimental uraemia and hypertension.  (+info)

The impact of an amino acid-based peritoneal dialysis fluid on plasma total homocysteine levels, lipid profile and body fat mass. (4/1382)

BACKGROUND: The caloric load from glucose-based peritoneal dialysis (PD) fluids contributes to hypertriglyceridaemia, adiposity and, as result of anorexia, protein malnutrition in PD patients. It has been suggested that replacement of a glucose-based by an amino acids-based PD fluid (AA-PDF) for one exchange per day might improve the nutritional status and lipid profile. Due to the uptake of methionine from the dialysate, however, exposure to AA-PDF might aggravate hyperhomocysteinaemia, a frequently occurring risk factor for atherosclerosis in uraemic patients. METHODS: We studied the impact of a once daily exchange with 1.1% AA-PDF instead of glucose-based PD fluid for 2 months on plasma methionine and total homocysteine (tHcy) levels, lipid profile, butyrylcholinesterase (BChE) and body fat mass of seven stable PD patients. Results are expressed as mean+/-SEM. RESULTS: Methionine levels did not increase significantly during therapy, but tHcy levels increased substantially from 60+/-12 to 84+/-19 micromol/l after 1 month (P=0.039), and to 85+/-22 micromol/l after 2 months of AA-PDF treatment. Serum triglyceride concentration decreased from 3.0+/-0.4 mmol/l at entry to 2.6+/-0.5 mmol/l (at 1 month, P=0.041 vs baseline). Serum BChE also decreased from 6.9+/-0.4 U/ml at entry to 6.3+/-0.4 U/ml after 2 months (P=0.014). Total cholesterol concentration and cholesterol fractions did not change. The reduced exposure to glucose-based PD fluid for 2 months resulted in a 0.5 kg reduction in fat mass which was due mainly to a reduction in fat mass of the trunk region (0.3 kg, P=0.031). CONCLUSIONS: It is concluded that methionine-containing AA-PDF induces an increase in the plasma tHcy level. This might, potentially, offset the beneficial effects of an improved serum lipid profile and reduced fat mass on the risk of cardiovascular disease in PD patients. Lowering the methionine content of the fluid, therefore, may be required to overcome this adverse effect.  (+info)

Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphate. (5/1382)

BACKGROUND: The abnormal control of parathyroid hormone secretion in chronic renal failure is attributed, in part, to down-regulation of the calcium-sensing receptor (CaR) in hyperplastic parathyroid tissue. The cause of this down-regulation is unknown. Here we examined the roles of uremia and parathyroid hyperplasia on parathyroid gland (PTG) CaR expression in the rat model of renal failure. METHODS: Rats made uremic by 5/6 nephrectomy were maintained for one month on diets containing 0.2% P (low phosphate), 0.5% P (normal phosphate) or 1.2% P (high phosphate); intact rats (controls) were maintained on the normal-phosphate diet. RESULTS: CaR mRNA was reduced only in uremic rats fed the high-phosphate diet (55% less than in controls, P < 0.05). Immunohistochemical staining revealed decreased CaR protein expression in uremic high-phosphate rat PTG compared with controls (41% decrease as determined by computer-assisted quantitation, P < 0.01). PTG size was increased in uremic rats fed the high-phosphate diet compared with controls (2.77 +/- 0.95 vs. 0.77 +/- 0.16 microgram/g body wt, P < 0.0001). There was no increase in PTG size in uremic rats fed the low-phosphate and normal-phosphate diets (0.92 +/- 0.31 and 1.01 +/- 0.31 micrograms/g) compared with controls (0.77 +/- 0.16 microgram/g body wt). Immunohistochemical staining for proliferating cell nuclear antigen in hyperplastic PTG from uremic rats showed that CaR was decreased primarily in areas of active cell proliferation. CONCLUSION: These results suggest that CaR down-regulation cannot be attributed to uremia per se, but rather, is associated with parathyroid cell proliferation. Furthermore, dietary phosphate restriction prevents both the parathyroid hyperplasia and decreased CaR expression in renal failure.  (+info)

Evidence of splanchnic-brain signaling in inhibition of ingestive behavior by middle molecules. (6/1382)

Anorexia, nausea, and vomiting are common symptoms of uremic intoxication. Fractions in the middle molecule weight range, isolated from normal urine and uremic plasma ultrafiltrate, inhibit ingestive behavior in the rat. To investigate their site of action and specificity, male rats were injected intraperitoneally, intravenously, or intracerebroventricularly with concentrated fractions of uremic plasma ultrafiltrate or normal urine (molecular weight range: 1.0 to 5.0 kD) and tested for ingestive and sexual behavior. An intraperitoneal injection of 0.5 ml of urine fraction (10:1) or 2.0 ml of uremic plasma ultrafiltrate fraction (25:1) inhibited carbohydrate intake by 76.3 and 45.9%, respectively, but an intravenous injection had no effect. However, intravenous injection of higher doses inhibited carbohydrate ingestion. An intracerebroventricular injection of 5 or 10 microl of urine (20:1) middle molecule fraction inhibited carbohydrate intake by 13.4 and 41.6%, respectively. An injection of 5 or 10 microl of uremic plasma ultrafiltrate (125:1) middle molecule fraction inhibited carbohydrate intake by 22.6 and 49.5%, respectively. Injections of the corresponding fraction from normal plasma ultrafiltrate had no effect. Injection of urine or uremic plasma ultrafiltrate middle molecule fractions did not affect the display of sexual behavior. These results suggest that middle molecule fractions from uremic plasma ultrafiltrate or normal urine act in the splanchnic region and/or brain to inhibit food intake and that the effect is specific for ingestive behavior.  (+info)

Association of morbidity with markers of nutrition and inflammation in chronic hemodialysis patients: a prospective study. (7/1382)

BACKGROUND: Numerous studies suggest a strong association between nutrition and clinical outcome in chronic hemodialysis (CHD) patients. Nevertheless, the pathophysiological link between malnutrition and morbidity remains to be clarified. In addition, recent evidence suggests that nutritional indices may reflect an inflammatory response, as well as protein-calorie malnutrition. In this study, we prospectively assessed the relative importance of markers of nutritional status and inflammatory response as determinants of hospitalization in CHD patients. METHODS: The study consisted of serial measurements of concentrations of serum albumin, creatinine, transferrin, prealbumin, C-reactive protein (CRP), and reactance values by bio-electrical impedance analysis (BIA) as an indirect measure of lean body mass every 3 months over a period of 15 months in 73 CHD patients. Outcome was determined by hospitalizations over the subsequent three months following each collection of data. RESULTS: Patients who required hospitalization in the three months following each of the measurement sets had significantly different values for all parameters than patients who were not hospitalized. Thus, serum albumin (3.93 +/- 0.39 vs. 3.74 +/- 0.39 g/dl), serum creatinine (11.0 +/- 3.7 vs. 9.1 +/- 3.5 mg/dl), serum transferrin (181 +/- 35 vs. 170 +/- 34 mg/dl), serum prealbumin (33.6 +/- 9.2 vs. 30.0 +/- 10.1 mg/dl), and reactance (50.4 +/- 15.6 vs. 43.0 +/- 13.0 ohms) were higher for patients not hospitalized, whereas CRP (0.78 +/- 0.89 vs. 2.25 +/- 2.72 mg/dl) was lower in patients who were not hospitalized. All differences were statistically significant (P < 0.05 for all parameters). When multivariate analysis was performed, serum CRP and reactance values were the only statistically significant predictors of hospitalization (P < 0.05 for both). When a serum CRP concentration of 0.12 mg/dl was considered as a reference range (relative risk 1.0), the relative risk for hospitalization was 7% higher (relative risk = 1.07) for a CRP concentration of 0.92 mg/dl and was 30% (relative risk = 1.30) higher for a CRP concentration of 3.4 mg/dl. When a reactance value of 70 ohms was considered as a reference range with a relative risk of 1.0, the relative risk of hospitalization increased to 1.09 for a reactance value of 43 ohms and further increased to 1.14 for a reactance value of 31 ohms. CONCLUSIONS: The results of this study strongly indicate that both nutritional status and inflammatory response are independent predictors of hospitalization in CHD patients. CRP and reactance values by BIA are reliable indicators of hospitalization. Visceral proteins such as serum albumin, prealbumin, and transferrin are influenced by inflammation when predicting hospitalization. When short-term clinical outcomes such as hospitalizations are considered, markers of both inflammation and nutrition should be evaluated.  (+info)

Increased erythrocyte 3-DG and AGEs in diabetic hemodialysis patients: role of the polyol pathway. (8/1382)

BACKGROUND: 3-Deoxyglucosone (3-DG) accumulating in uremic serum plays an important role in the formation of advanced glycation end products (AGEs). To determine if 3-DG is involved in the formation of intracellular AGEs, we measured the erythrocyte levels of 3-DG and AGEs such as imidazolone and N epsilon-carboxymethyllysine (CML) in hemodialysis (HD) patients with diabetes. Further, to determine if the polyol pathway is involved in the formation of erythrocyte 3-DG and AGEs, an aldose reductase inhibitor (ARI) was administered to these patients. METHODS: The erythrocyte levels of sorbitol, 3-DG, imidazolone, and CML were measured in ten diabetic HD patients before and after treatment with ARI (epalrestat) for eight weeks, and were compared with those in eleven healthy subjects. 3-DG was incubated in vitro with hemoglobin for two weeks to determine if imidazolone and CML are formed by reacting 3-DG with hemoglobin. RESULTS: The erythrocyte levels of sorbitol, 3-DG, imidazolone, and CML were significantly elevated in diabetic HD patients as compared with healthy subjects. The erythrocyte levels of 3-DG significantly decreased after HD, but sorbitol, imidazolone or CML did not. The administration of ARI significantly decreased the erythrocyte levels of sorbitol, 3-DG and imidazolone, and tended to decrease the CML level. Imidazolone was rapidly produced in vitro by incubating 3-DG with hemoglobin, and CML was also produced, but less markedly as compared with imidazolone. CONCLUSION: The erythrocyte levels of 3-DG and AGEs are elevated in diabetic HD patients. The administration of ARI reduces the erythrocyte levels of 3-DG and AGEs, especially imidazolone, as well as sorbitol. Thus, 3-DG and AGEs, especially imidazolone, in the erythrocytes are produced mainly via the polyol pathway. ARI may prevent diabetic and uremic complications associated with AGEs.  (+info)

What are the symptoms of chronic uremia? Due to chronic uremia is a systemic multi-organ damage, so a wide variety of clinical manifestations: Water-electrolyte metabolic disorders of chronic renal failure renal regulation of water and elect
1. The effect of uraemia on the rates of protein synthesis and protein degradation in liver, heart and vastus lateralis muscle were examined in the rat. Uraemia was induced by a five-sixths nephrectomy and the rates of protein turnover were compared with pair-fed sham-operated littermate controls.. 2. The procedure produced plasma concentrations (means ±sem) of urea of 7.3 ±0.4 mmol/l in control and 39 ± 2 mmol/l in uraemic rats, and of creatinine of 41 ± 1 μmol/l in control and 133 ± 7 μmol/l in uraemic rats.. 3. Uraemia reduced the rates of protein synthesis in liver, heart and muscle by 35 ±5, 4.0 ±1.2 and 4.0 ± 0.6%/day, respectively, compared with control rats (P , 0.01). Since the reductions in tissue growth rate were too small to be accounted for by the reduction seen in protein synthesis alone, this implied that protein degradation was also reduced. Uraemia also caused an 18% reduction in the rate of growth as measured by the increase in tail length (P , 0.01).. 4. Uraemia ...
1. The role of endogenous opioids on the reflex cardiovascular control of chronic uraemic patients was investigated.. 2. The opiate antagonist naloxone administered intravenously caused a significant increase in the abnormal Valsalva manoeuvre ratio in nine chronic uraemic patients, but it had no effect in six diabetic patients with normal renal function, whose response to the Valsalva manoeuvre was similar to that of chronic uraemic patients. Naloxone had no effect in eight normal subjects.. 3. The increase in the Valsalva ratio observed in uraemic patients was due to restoration of the parasympathetically mediated reflex bradycardia of the release phase of the manoeuvre.. 4. Naloxone did not modify supine and standing blood pressure and heart rate in any group.. 5. Endogenous opioids may be involved in the defective autonomic control of heart rate in uraemic patients. ...
Abstract: Content of free ammonia and glutamine amide nitrogen was increased but content of protein amide nitrogen was decreased in brain tissue after bilateral nephrectomy of rats causing development an experimental uremia; an increased synthesis of urea and activation of arginase were observed in liver tissue. Flavonoids robinine and hyperine decreased the content of free ammonia, increased the content of glutamine amide nitrogen as well as of protein amide nitrogen in rat brain; robinine decreased slightly the urea synthesis and the arginase activity in liver slices of the nephrectomized ...
Now the incidence of uremia is getting higher and higher, many patients have after uremia will know how to prevent uremia, they are afraid of uremia treatment is not good, and worried that will not infect relatives. In fact, uremia is not c
Recurrent hemodialysis has become a successful form of therapy for patients with end-stage chronic renal failure. At the present time, several hemodialysis centers both in the United States and abroad are actively involved in maintaining and rehabilitating patients having essentially no renal function.. Dialysis therapy for end-stage renal disease was first successully attempted by Scribner and associates (1) in 1960. Subsequently numerous other investigators (2-10) have reported on dialysis in chronic uremia with varying degrees of success. The development of first a Teflon (11) and then a Silastic-Teflon arteriovenous shunt (12), as well as the pumpless low-temperature dialysis technique (13), ...
Gastrointestinal mucosal abnormalities ranging from edema to ulceration occur in two thirds of patients dying of uremia. Early studies suggested that uremic patients on maintenance dialysis treatment were at increased risk of peptic ulceration but more recent data indicate that this is not so. Other gastrointestinal problems reported for uremic subjects on maintenance dialysis treatment include bleeding from telangiectatic lesions, constipation, mucosal deposition of amyloid and acute pancreatitis. Nausea and vomiting are common in the uremic patient but gastric emptying studies have yielded conflicting results. Patients undergoing renal transplantation are at increased risk of development of esophagitis, complicated peptic ulcer, intestinal ulceration, and perforation as well as acute pancreatitis ...
Many uremic patients often have the symptom of tic, especially in the evening. Why patients with Uremia appear tic? And is tic a normal symptom for patients with uremia? Uremia experts said that uremia is not a single disease, but a poisoni
Segments of ileum or jejunum were isolated from the remaining bowel and one or both ends exteriorized in 19 chronically uremic patients. The etiology of their uremia varied widely, and all patients but one had endogenous creatinine chromogen clearances of less than 4 ml/min. Sixteen patients had undergone previous peritoneal or hemodialysis. There were no operative deaths. Two patients were totally anuric, and one of these was able to be discharged to dialyze herself at home. Of eight other patients who were able to be discharged and dialyze themselves at home, the longest follow up has been 21 months. Urea ...
Uremia is a syndrome which arises as a direct consequence of complete loss of renal function and is the clinical end-point of progressive acute or chronic renal failure. Renal failure, acute or chronic, occurs due to a decline in Glomerular Filtration Rate (GFR). Uremia arises when GFR is extremely low, resulting in an inability of the kidneys to properly regulate electrolyte and water levels along with an inability to secrete sufficient amounts of metabolic waste products. Additional components of uremia arise because the highly dysfunctional kidneys can no longer secrete sufficient levels of hormones ...
All kinds of chronic kidney disease running to the later period can cause renal function damage, it can be called chronic renal failure, uremia is the later period. So how to prevent uremia? Preventing uremia needs to a integral plan: all k
With the improvement of living standards, more and more men suffering from uremia, harm the disease for men is great, so you know what the early symptoms of male uremia with it, only to understand the early symptoms of male uremia, is it po
The aim of this study was to establish, by means of peripheral quantitative computed tomography (pQCT) at the distal radius, the existence of cortical and/or trabecular osteopenia, and to assess the integrity of bone geometry in uremic patients undergoing maintenance hemodialysis. Our results show a clearcut selective reduction in volumetric cortical density, more evident in women (p = -0.0001) than men (p = 0.030), which appears to be independent of age and menopausal status. Trabecular density was not significantly changed in either sex. Cortical density of the patients correlated inversely with age (p = 0.003), duration of dialysis (p = 0.002) and parathyroid hormone (PTH) levels (p = 0.03). Trabecular density correlated only with age. Normally, cortical density is age-dependent and its reduction is accompanied by compensatory geometry changes. Compared with control subjects, in our female patients both cortical area and cortical thickness were reduced (p = 0.02 and 0.008), while ...
Sleep disorder is a lasting torment for some patients with Uremia. It can disorder the normal physiological and metabolic activities. Also it can affect their life quality and make them feel tired all day long. Why patients with Uremia suffer from sleep disorder? Is there any way to relieve it ...
Have you been lately suffering from problems like nausea, irregular heartbeat, respiratory shortness or confusion? You might be having a renal disease known as Uremia. Find out all about the condition, including its causes, symptoms, diagnosis, What is Uremia? This is a toxic disease resulting from kidney disorder that
Alfiya is 45 years old, comes from Novosibirsk, Russia and she is a patient with chronic nephritis and uremia. In her local hospital, she also accepts treatment but gradually her disease develops to uremia.
This study was undertaken to define the hemodynamic changes in hypertension of chronic end-stage renal disease. Mean cardiac index in 75 uremic patients was higher (P , 0.001) than that of 42 normal volunteers while stroke index was not different from normals. The higher cardiac indices of uremic patients were accounted for by increased heart rates. Despite the significantly higher blood pressure in the uremics, their mean total peripheral resistance index was not different from that of normals.. The total group of 75 patients included 52 hypertensive and 23 normotensive uremics. Cardiac index, heart rate, and stroke index were the same in 52 hypertensive and 23 normotensive uremics while mean total peripheral resistance index of hypertensive uremics was higher (P , 0.001) than normotensive uremics. Therefore, the hypertension in end-stage renal disease is sustained by a high total peripheral resistance.. Bilateral nephrectomy in 12 hypertensive uremics resulted in no changes in cardiac index; a ...
Background. Uraemic toxicity results in the dysfunction of many organ systems, provoking an increase in morbidity and mortality. To date, only ∼90 uraemic retention solutes have been described. To examine unknown uraemic substances thoroughly, the identification of as many compounds as possible in the ultrafiltrate and/or plasma of patients would lead to a less biased definition of the uraemic retention process compared with what is proposed today.. Methods. We describe the application of a novel proteomic tool for the identification of a large number of molecules present in ultrafiltrate from uraemic and normal plasma obtained with high- or low-flux membranes. Separation by capillary electrophoresis was coupled on-line to a mass spectrometer, yielding identification of polypeptides based on their molecular weight.. Results. Between 500 and ,1000 polypeptides with a molecular weight ranging from 800 to 10 000 Da could be detected in individual samples, and were identified via their mass and ...
Uremia is a Greek word that means urine in the blood. Uremia develops as the kidneys fail and are unable to remove wastes from the body. There are many symptoms of uremia that occur as kidney function declines. Before severe uremia develops, treatments such as dialysis and transplantation are usually needed. The timing of dialysis will depend on your symptoms and varies from person to person.. ...
Chronic renal failure refers to all kinds of kidney diseases caused by slow progressive renal damage resulting in uremia and renal function loss, cause a series of clinical symptoms and biochemical metabolic disorders, endocrine of clinical
TY - JOUR. T1 - Renin-angiotensin gene polymorphism in children with uremia and essential hypertension. AU - Papp, Ferenc. AU - Friedman, Aaron L.. AU - Bereczki, Csaba. AU - Haszon, Ibolya. AU - Kiss, Éva. AU - Endreffy, Emöke. AU - Túri, Sándor. PY - 2003/2/1. Y1 - 2003/2/1. N2 - The M235T polymorphism of the angiotensinogen (ANG) gene, the I/D polymorphism of the angiotensin converting enzyme (ACE) gene, and the A1166C polymorphism of the angiotensin II type 1 receptor (AT1R) gene were identified in 70 patients with end-stage renal disease [20 pediatric ESRD, aged 14.9±3.1, years blood pressure (BP) 139±14/91±13 mmHg, 50 adult ESRD , aged 48.7±18.7 years, BP 149.1±24/96.9±12 mmHg], 35 with juvenile essential hypertension (JEHT, aged 14.4±2.7 years, 24-h mean BP 135.37±7.37/72.4±7.68 mmHg), 130 adult healthy normotensive controls (aged 34.9±8.1 years, BP 117.8±8.7/78. 7±8.5 mmHg), and 20 pediatric controls (aged 13.2±1.2 years, BP 109±6.5/71±5.9 mmHg). The ACE gene ...
When doctors are checking patients condition, patients always ask how long kidney disease will develop to uremia. If you can control your indexes, your condition can be controlled as well. Follow us to see some tips for the prevention of ur
List of causes of Bladder symptoms and Gait disorder and Uremia, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
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Modern medicine thinks that the over intake or too less intake of protein is not good for kidney, in particular the masses of protein intake can generate much more metabolism of it such as Uremia toxin including urea, creatinie, carbamidine, polyamine and middle molecular substances. Controlling the intake of protein(when it is renal failure,patients should take a low-protein diet.) can play a great role in alleviating renal burden, reducing the generation of uremia toxin and relieving the disease condition ...
Uraemia is a term which tends to be appied to describe the syndrome associated with an accumulation of all sorts of renally cleared waste products, and is not necessarily referring to the accumulation of urea alone. However, urea is the most abundant waster product among those whcih accumulate, and it seems to have some important toxic effects.
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Patients in stage of Uremia are easily to have lots of severe symptoms. Swelling legs, high creatinine level and shortness of breath can bring risk for patients. For that, we have solution.
1.Renal failure is a great harm to human kidney renal failure, if treated properly, it will cause uremia, and even threaten the safety of themselves, understand the symptoms of renal failure in each stage, early treatment of renal failure is urgent. Next
The population of microbes (microbiome) in the intestine is a symbiotic ecosystem conferring trophic and protective functions. Since the biochemical environment shapes the structure and function of the microbiome, we tested whether uremia and/or dietary and pharmacologic interventions in chronic kid …
Systemic: Age, anaemia, drugs, genetic disorders, hormones, diabetes, malignant disease, malnutrition, obesity, systemic infection, temperature, trauma, hypovolaemia, hypoxia, uraemia, vitamin deficiency (C), trace metal deficiency (Cu, Zn ...
Question - Does dialysis causes apetite loss?. Ask a Doctor about diagnosis, treatment and medication for Uremia, Ask a Nephrologist
Looking for online definition of uraemia in the Medical Dictionary? uraemia explanation free. What is uraemia? Meaning of uraemia medical term. What does uraemia mean?
TY - JOUR. T1 - Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels. AU - Moe, Sharon. AU - Duan, Danxia. AU - Doehle, Brian P.. AU - ONeill, Kalisha D.. AU - Chen, Xuening (Neal). PY - 2003/3/1. Y1 - 2003/3/1. N2 - Background. Bone matrix proteins are expressed in calcified arteries from dialysis patients, suggesting that vascular smooth muscle cells (VSMCs) may transform to osteoblast-like cells. One of the key transcriptional regulators of osteoblast differentiation is Cbfa1. Thus, we hypothesized that this may be a key factor in arterial calcification. Methods. To test this hypothesis, we examined sections of the inferior epigastric artery from uremic patients for the presence of Cbfa1 and type I collagen and osteopontin by in situ hybridization and immunostaining. We also examined the effect of pooled uremic sera from dialysis patients on the expression of Cbfa1 by reverse transcription-polymerase chain reaction (RT-PCR) in bovine VSMCs in vitro. Results. ...
Background.. Uremic pruritus is still a common phenomenon in patients with end-stage renal failure. It is regarded as one of the most bothersome symptoms in patients on chronic dialysis.. The pathogenesis of uremic itch remains unclear. Several theories have been proposed like dryness of the skin, imbalance in divalent ions, peripheral neuropathy and others.. Many treatment modalities have been tried to reduce uremic pruritus, however , the majority of them produced only temporary improvement. Therefore , every new therapeutic option for uremic pruritus is desirable.. This study will undertaken to evaluate the efficacy of a cream which included olive oil and omega-3 fatty acids.. Olive Omega-3 is an efficient product that soothes itchiness of cracked and very dry skin.. The product is unique and based on patented technology developed by the Technion Research and Development Foundation in Haifa.. Olive Omega-3 is an ointment composed of all natural ingredients. The main active ingredients are ...
Background.. Uremic pruritus is still a common phenomenon in patients with end-stage renal failure. It is regarded as one of the most bothersome symptoms in patients on chronic dialysis.. The pathogenesis of uremic itch remains unclear. Several theories have been proposed like dryness of the skin, imbalance in divalent ions, peripheral neuropathy and others.. Many treatment modalities have been tried to reduce uremic pruritus, however , the majority of them produced only temporary improvement. Therefore , every new therapeutic option for uremic pruritus is desirable.. This study will undertaken to evaluate the efficacy of a cream which included olive oil and omega-3 fatty acids.. Olive Omega-3 is an efficient product that soothes itchiness of cracked and very dry skin.. The product is unique and based on patented technology developed by the Technion Research and Development Foundation in Haifa.. Olive Omega-3 is an ointment composed of all natural ingredients. The main active ingredients are ...
TY - JOUR. T1 - Nitrogen sparing effect of essential amino acids in uremia. AU - Abitol, C.. AU - Holliday, M.. PY - 1975/1/1. Y1 - 1975/1/1. N2 - This study was designed to determine whether essential amino acids administered during night time fasting would improve the nutritional status of uremic children. Seven children (8-14 yr) with mean SUN=107 mgn% were given 10% glucose and essential amino acid nitrogen (EAAN) to provide 0.25-0.5 gm/K/night for 5 nights following a control period of one night. Ad libitum diet provided a mean of 69 Kcal/K/day (Range 26-109) and 0.68 gm Protein/k/day (Range 0.12-1.37). Urea production (UrP)/24 hr was determined from change in urea nitrogen pool and urinary excretion. Apparent protein synthesis (PrS) was determined as the difference between total nitrogen intake (NI) and UrP. Results were evaluated by testing the correlation of nitrogen intake with urea production and apparent protein synthesis. Infusion of EAAN in uremic patients may promote protein ...
Bone specimens from 42 patients with end-stage renal disease and from 9 patients without renal or bone disease have been analyzed for the content of fluoride, calcium, and phosphorus. Thirty-one patients were treated with chronic hemodialysis for periods ranging up to 56 months by employing dialysate made up with tap water containing 1 ppm fluoride. Fluoride content of cortical hard bone was increased in the great majority of patients with kidney disease. There was no significant difference in bone fluoride content between the patients who were dialyzed and those who were not. However, the content of calcium and phosphorus was lower in the patients treated by hemodialysis. There was no correlation between duration of uremia or number of dialyses and bone fluoride content. In 4 patients, 3 with kidney disease and 1 without, soft bone and soft tissue had much higher fluoride content than cortical bone.. ...
Criteria for the diagnosis of uraemia as a result of benign essential nephrosclerosis were established in a group of 12 patients, most of whom had a long history of inadequately treated hypertension, arteriosclerosis, cardiomegaly and mild proteinuria.
Introduction: Neuropathy is a frequent complication of uremic disease, causing motor and sensorial symptoms, mostly localized in the lower limbs. Another symptom related to uremic disease is pruritus, which may be diffuse all over the body, but usually occurring in the lower limbs. In the terminal phase therapeutic measures are taken, targeting the sensitive components of neuropathy, with the use of drugs against pain, and targeting itching, using different substances, the most widely used of which is gabapentin.Methods: The severity of neuropathy is variable, ranging from slight to severe and may or may not be associated with the length of chronic dialysis treatment. The use of measurement scales of pain, VAS type adapted to the itching, may link both conditions of neuropathy and itching. Results: We noted that a severe intensity of pruritus can be related to severity of neuropathy in uremic subjects and may become predictive of progressing neuropathy.Conclusions: In this study we examined a group
Total or nearly total and permanent kidney failure is called ESRD. If a persons kidneys stop working completely, the body fills with extra water and waste products. This condition is called uremia. Hands or feet may swell. A person will feel tired and weak because the body needs clean blood to function properly.. Untreated uremia may lead to seizures or coma and will ultimately result in death. A person whose kidneys stop working completely will need to undergo dialysis or kidney transplantation.. Dialysis. The two major forms of dialysis are hemodialysis and peritoneal dialysis. Hemodialysis uses a special filter called a dialyzer that functions as an artificial kidney to clean a persons blood. The dialyzer is a canister connected to the hemodialysis machine. During treatment, the blood travels through tubes into the dialyzer, which filters out wastes, extra salt, and extra water. Then the cleaned blood flows through another set of tubes back into the body. The hemodialysis machine monitors ...
If the kidneys are damaged, patients either no longer urinate or produce a lot less urine while waste products continue to be produced. These waste products and water build up in the bloodstream. This condition is called uraemia. Your hands or feet may swell and you may become breathless. Your blood pressure may rise and your body does not produce enough red blood cells. You may develop fatigue, nausea, and loss of appetite. Untreated uraemia may lead to seizures or coma and will ultimately result in death.. When the kidneys function at 15 per cent or less, this is called kidney failure. Dialysis or transplantation may be the only ways to replace your lost kidney function ...
Uremia has long been recognized to disrupt the normal physiology of numerous organs, including the heart (2,3). Over the last 30 years, echocardiography studies have found adverse changes in cardiac structure and function associated with end-stage renal disease (ESRD), which is collectively termed uremic cardiomyopathy. These cardiac abnormalities, including left ventricular hypertrophy and systolic dysfunction, are common in hemodialysis and are associated with an increased risk of adverse clinical outcomes (4). However, the precise nature of the uremic mediators of cardiac dysfunction remain elusive. Kidney transplantation is the treatment of choice for selected patients with ESRD. A successful kidney transplantation improves the quality of life and reduces the mortality risk for most patients compared with maintenance dialysis (5). However, 50% to 60% of deaths among kidney transplantation recipients are directly attributable to cardiovascular disease. In addition, death from cardiovascular ...
Despite this reclassification, abnormalities of cardiac structure or function are still frequent when CMR is performed in ESRD. In a pivotal study of 134 patients who had been undergoing renal replacement therapy for an average duration of 12 months, CMR with gadolinium (Gd) contrast agents was performed on the post-dialysis day or at dry weight for peritoneal dialysis (9). The most frequent abnormality detected was LVH (72%), with comparatively low rates of LV dilation (11%) and LV systolic dysfunction (8%). The importance of an accurate, volume-independent measure of cardiac mass is paramount, given that LVH is a strong independent risk factor for mortality, cardiac arrhythmia, and heart failure in patients undergoing dialysis (10). However, the categorization of patients as having LVH is not a biological dichotomy; LV mass is a continuous variable with a graded relationship with cardiovascular risk. This is reflected by improved cardiovascular outcomes with LV mass regression when both LV ...
Cardiovascular disease (CVD) continues to account for a very high percentage of deaths in patients with ESRD. An entire gamut of risks factors-some well known, some still being understood and yet more putative are operational in patients with renal disease. CVD assumes enhanced importance in the wake of its disproportionate effect on patients with uremia. Some studies have reported an upto 15 fold higher cardiovascular death rate in patients on PD when compared to non-uremic cohorts. Thus it follows that the longevity of patients on PD is directly related to improvements in the recognition, management and prevention of CVD. While the conventional risk factors like age/diabetes/hypertension/ hyperlipidemia/smoking etc need no elaboration, factors unique to renal failure like calcium/ phosphorus/Vitamin D abnormalities, anemia, dialysis related chronic inflammation etc add to the burden and pathogenesis of CVD. Specific to PD, certain abnormalities like hypoalbuminemia and attendant malnutrition, ...
Abnormal polycystin-1 causes abnormality of proliferation and differentiation of tubular cells. These cells proliferate and form cysts which eventually detach from the tubules. The cells secrete fluid into the cyst. An inflammatory response and interstitial fibrosis are initiated.. The mutations may also be in the PKD2 gene, but this is not as common as with PKD1. PKD2 codes for polycystin-2, which is also located in the cilia, and leads to the same consequences. However, patients with mutations in PKD2 have a slower rate of disease progression.. Clinical features: Large cysts occur throughout the kidney. The cysts themselves can be as big as 3-4 cm, filled up with fluid, and no parenchyma can be seen in-between. Patients suffering from this will have enormous kidneys, and they can weight up to 4 kg!. ADPKD is a systemic disease, so cysts will form in other organs as well, like in the pancreas, spleen and as aneurysms in the circle of willis, also known as berry aneurysms. The cysts that occur ...
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1. The chemical mediator of renal hypertension is rapidly destroyed by the metabolic activity of the normal kidney. The excretory function of the kidney plays little, if any, rôle in eliminating the mediator of hypertension. 2. If specific substances are responsible for the uremic syndrome, they are neither produced nor eliminated to any significant extent by the metabolic activity of the kidneys. The elimination of these postulated uremia-producing substances would have to be primarily dependent upon the excretory activities of the kidney. 3. No evidence was obtained to support the view that a unilateral ureterovenous fistula leads to nephrotoxic symptoms. ...
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ESRD (Uremia) is a series of syndromes that various kidney diseases progress into the end stage. In this stage, patients renal function decreases severely in which the renal damage is irreversible. Is it possible to reverse kidney disease
Kidney diseases are not easy to be treated. At the early stage, there are no obvious symptoms, which usually delays the best treatment time. When the illness condition develops into Renal Failure or Uremia, many patients will choose dialysi
Kidney failure is a chronic kidney disease. It is will progress in to uremia without proper treatments. Besides, patients will suffer from some symptoms and complications, such as fatigue, poor appetite, ammoniacal tastes in their mouth, th
Urinary protein is the most common factor leading to the progression of chronic kidney disease. It must be controlled within 0.5 g/24h to effectively prevent the progression of kidney disease to uremia. There are many ways to reduce it.
For kidney patients, the most horrible thing may be the uremia. Theres nothing more hopeless than watching creatinine levels rise and being told by your doctor that theres no way to treat it and that youll have to wait for hemodialysis
COELHO, M. Análise de componentes do sistema renina-angiotensina-aldosterona em cães com doença renal crônica. 2019. 65 f. Dissertação (Mestrado) - Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Pirassununga, 2019. O sistema renina-angiotensina-aldosterona (SRAA) influencia diretamente o desenvolvimento da hipertensão arterial sistêmica (HAS) e proteinúria em pacientes com doença renal crônica (DRC). Sendo assim, o objetivo deste projeto foi avaliar a atividade do SRAA, por meio da concentração plasmática de aldosterona ([aldo]p) e atividade plasmática da renina (APR), em cães hígidos e com DRC de ocorrência natural, procurando associar tais parâmetros com a condição clínica e a evolução da doença nos cães com DRC. Os cães foram avaliados por exame físico e exames laboratoriais. A [aldo]p e a APR foram determinadas por radioimunoensaio. Os cães do grupo DRC apresentaram manifestações clínicas condizentes com uremia, além de anemia, ...
After reading the book, I would have to say a little bit of both, given the limitations of medical knowledge at the time. In Londons view, common back then, dipsomania was a chemical, congenital defect, much maligned and considered to be as rare as one in every several thousand drinkers. Nonetheless, several prominent London biographers have asserted that Jack London was chronically drunk-sick in his later years, ultimately dying of uremia and other complications brought on by years of excessive drinking. Writer Upton Sinclair claimed in 1915 that he had seen London wandering Oakland dazed and disagreeably drunk. Still others claim Londons bar bills were always modest and much of John Barleycorn is fiction. Yet London writes frankly of his morning shakes and hair-of-the-dog drinking and suicidal impulses. Describing his life in 1910, London writes: I achieved a condition in which my body was never free from alcohol. Nor did I permit myself to be away from alcohol…. There was no time in ...
Merk Dagang : Dellacorta, Eltazon, Etacortin, Erlanison, Inflason, Kokosone, Metacort, Pehacort, Pimicort, Prednicap, Predsil, Remacort, Sohoson, Tiapren, Trifacort INDIKASI Artritis reumatoid, asma bronkhial, lupus eritematosus sistemik, demam reumatik yang berhubungan dengan karditis. KONTRA INDIKASI Tukak lambung, osteoporosis, diabetes melitus, penyakit infeksi sistemik, gagal ginjal kronis, uremia, hamil, tuberkulosa aktif, hipersensitif. PERHATIAN Tidak untuk terapi awal…
iklan1 Asuhan Keperawatan pada pasien mual dan muntah: Mual merupakan perasaan ingin muntah subjektif. Muntah adalah pengeluaran isi lambung melaui osofagus dan mulut. Mual dan muntah merupakan pengalaman yang hamper dirasakan semua orang. Muntah juga merupakan mekanisme pertahanan tubuh dari bahan yang berbahaya dari saluran pencernaan. Reflek muntah dikontrol oleh pusat muntah di otak. Mekanisme terjadinya mutah sangat komplek. Banyak penyebab yang dapat menyebabkan muntah yaitu: 1. 2. 3. 4. 5. 6. 7. infeksi virus stress kehamilan obat myocardial infark uremia kondisi lain Intervensi terapeutik Mual dan muntah sangat sedikit memerlukan intervensi. Akan tetapi jika dibiarkan akan menyebabkan dehidrasi dan ketidak seimbangan elektrolit. Kehilangan asam klorida dari lambung dapat menyebabkan terjadinya metabolic alkalosis. Muntah yang hitam seperti kofi menunjukan muntah bercampur dengan darah. Proteksi pada jalam napas selama muntah merupakan tindakan yang ling penting untuk mencegah adanya ...
Тележка предназначена для размещения стерилизатора СТЕРРАД NX на уровне, удобном для загрузки инструментария в камеру, обеспечивает доступ к аппарату со всех сторон и его транспортировку. Тележка представляет собой мобильную подставку под систему СТЕРРАД NX, оснащенную колесами с фиксатором ...
Acute: Uremia, high blood potassium, volume overload[2]. Chronic: Heart disease, high blood pressure, anemia[3][4]. ... Uremia was the term for the contamination of the blood with urea. It is the presence of an excessive amount of urea in blood. ... Use of the term uremia[edit]. Before the advancement of modern medicine, renal failure was often referred to as uremic ... Meyer, Timothy W.; Hostetter, Thomas H. (2007). "Uremia". New England Journal of Medicine. 357 (13): 1316-25. doi:10.1056/ ...
Uremia Unaffected Unaffected Prolonged Unaffected Congenital afibrinogenemia Prolonged Prolonged Prolonged Unaffected Factor V ...
"uremia , accumulation in the blood of constituents normally eliminated in the urine that produces a severe toxic condition and ... uremia). As a result, red blood cells may leak out of damaged glomeruli, causing blood to appear in the urine (hematuria). Low ...
Uremia was the term for the contamination of the blood with urine. It is the presence of an excessive amount of urea in blood. ... Dr Per Grinsted (2005-03-02). "Kidney failure (renal failure with uremia, or azotaemia)". Retrieved 2009-05-26. Dr Andy Stein ( ... Complications of acute disease may include uremia, high blood potassium, or volume overload. Complications of chronic disease ... Meyer, Timothy W.; Hostetter, Thomas H. (2007). "Uremia". New England Journal of Medicine. 357 (13): 1316-25. doi:10.1056/ ...
Ksiazek A, Załuska W (2008). "Sympathetic overactivity in uremia". J Ren Nutr. 18 (1): 118-21. doi:10.1053/j.jrn.2007.10.024. ...
She died of uremia. Longshore received private medical training from her brother-in-law Joseph before being among the first ...
Uremia. Sanandaj Calligraphers Association Exhibition; 1994, Gallery of Islamic Guidance Department; Sanandaj Iranian ...
"uremia , accumulation in the blood of constituents normally eliminated in the urine that produces a severe toxic condition and ... uremia).[5] As a result, red blood cells may leak out of damaged glomeruli, causing blood to appear in the urine (hematuria).[6 ...
Loirat C, Noris M, Fremeaux-Bacchi V (2008). "Complement and the atypical hemolytic uremia syndrome in children". Pediatr ...
Connors died of uremia in Chicago, Illinois. 'Illinois Blue Book 1961-1962,' Biographical Sketch of William J. Connors,' pg. ...
He died suddenly of uremia in 1904. A Chemical Study of the Osage Orange as a Substitute for the Mulberry in rearing Silkworms ...
Ketteler M (2005). "Fetuin-A and extraosseous calcification in uremia". Curr. Opin. Nephrol. Hypertens. 14 (4): 337-42. doi: ... prevents extraosseous calcification induced by uraemia and phosphate challenge in mice". Nephrol. Dial. Transplant. 22 (6): ...
Kidney failure and uremia will follow within hours. The cat becomes increasingly distressed, and may howl or cry out in pain. ... Renal failure and uremia will follow within 36-48 hours of complete urethral obstruction. The time from complete obstruction ... Intravenous fluids are given to treat uremia. Antibiotics and a special diet may be prescribed. Diets low in magnesium and ...
Wilson died from uremia and was buried in Pondicherry, India, in 1944.[5] ...
He died on August 9, 1913 of uremia. "National Democratic Body Loses R. E. L. Mountcastle and T. J. McCue". New York Times. ...
Death usually resulted from uremia or respiratory failure. With corticosteroids and cyclophosphamide, 5-year survival is over ...
It undergoes some first-pass-metabolization leading to an oral bioavailability of 50-95%. Patients with uremia may have a ...
The cause of death was listed as uremia. He was buried at the Old Cathedral Cemetery in Philadelphia. "Studs Bancker Statistics ...
In early January 1725, Peter was struck once again with uremia. Legend has it that before lapsing into unconsciousness Peter ...
Uremia, Trauma, Insulin overdose or inflammatory disorders, Poisoning and psychogenic causes, and Shock. ...
Symptoms include localized pain and uraemia (poisoning due to reabsorbed waste). The recovery rate is high, with most ...
It can lead to uremia and acute kidney injury (kidney failure) if not controlled. Oliguria or anuria (decreased or absent urine ... Renal azotemia (acute kidney failure) typically leads to uremia. It is an intrinsic disease of the kidney, generally the result ...
p. 1. "Death Claims Gifted Writer: 'Herb' Lampman Dies of Uremia". The Oregonian. July 1, 1943. p. 9. "Ben Hur Lampman Dies ...
He died of uremia at the age of 48. "Skyrocket Smith Death Certificate". thedeadballera.com. Retrieved 2010-10-27. Archived ...
Widtsoe died in Salt Lake City, Utah, of uremia; he also had prostate cancer for a number of years before his death. He was ...
He died of uraemia aged 57. He is buried in Brompton Cemetery, London. His grave is only 200 yards away from that of fellow ...
Regarding uremia, he divided associated symptoms into two criteria called "true uremia" and "pseudo-uremia". Pseudo-uremia was ... Volhard also performed extensive studies involving renovascular hypertension and uremia. ...
envelenamento, uremia e sobredose. Soterrado. Jack London State Historic Park. Nacionalidade. Estados Unidos de América. ...
... parathyroid hormone and vascular calcification in uremia". Blood Purification. 20 (5): 494-7. doi:10.1159/000065203. PMID ...
Lieber CS, Lefèvre A (August 1959). "AMMONIA AS A SOURCE OF GASTRIC HYPOACIDITY IN PATIENTS WITH UREMIA". J. Clin. Invest. 38 ( ...
Uremia and Cardiovascular Mortality SANDOR A. FRIEDMAN, M.D., F.A.C.P.; HERMAN ROSEN, M.D., F.A.C.P. ... Uremia and Cardiovascular Mortality. Ann Intern Med. 1974;81:696-697. doi: 10.7326/0003-4819-81-5-696 ...
Zinc Tolerance Test in Uremia: Effect of Ferrous Sulfate and Aluminum Hydroxide Annals of Internal Medicine; 104 (1): 50-52 ... Carbohydrate Metabolism in Uremia EDWARD S. HORTON, M.D.; CHARLES JOHNSON, M.D.; HAROLD E. LEBOVITZ, M.D. ... It is unlikely that urea per se is the cause of the abnormal glucose tolerance in uremia, as no effect of urea on insulin- ... Osteomalacia After Parathyroidectomy in Patients with Uremia Annals of Internal Medicine; 96 (1): 34-39 ...
Severe uremia is now a rare occurrence in most developed nations, and yet is still present in many countries of the world. It ... We present the case of a young adult with severe uremia who, despite application of recommended measures, developed DDS and non ... Dialysis disequilibrium syndrome and other treatment complications of extreme uremia: a rare occurrence yet not vanished.. ...
List of causes of Bladder symptoms and Gait disorder and Uremia, alternative diagnoses, rare causes, misdiagnoses, patient ... Uremia:*77 causes: Uremia *Introduction: Uremia *Uremia: Add a 4th symptom *Uremia: Remove a symptom Results: Causes of Bladder ... Bladder symptoms AND Gait disorder AND Uremia: Causes of All Symptoms. *Bladder symptoms OR Gait disorder OR Uremia: 1044 ... Bladder symptoms AND Gait disorder AND Uremia - Causes of All Symptoms *Bladder symptoms OR Gait disorder OR Uremia - 1044 ...
Protein Turnover in Uraemia in the Rat S. B. Ireland; S. B. Ireland ... Uraemia also caused an 18% reduction in the rate of growth as measured by the increase in tail length (P , 0.01). ... Uraemia was induced by a five-sixths nephrectomy and the rates of protein turnover were compared with pair-fed sham-operated ... 3. Uraemia reduced the rates of protein synthesis in liver, heart and muscle by 35 ±5, 4.0 ±1.2 and 4.0 ± 0.6%/day, ...
Gastrointestinal mucosal abnormalities ranging from edema to ulceration occur in two thirds of patients dying of uremia. Early ... Kang, J.Y. (1993). The gastrointestinal tract in uremia. Digestive Diseases and Sciences 38 (2) : 257-268. [email protected] ...
Find out all about the condition, including its causes, symptoms, diagnosis, What is Uremia? This is a toxic disease resulting ... You might be having a renal disease known as Uremia. ... Uremia and Diet. Dietary changes should be made for Uremia ... Uremia and Acute Tubular Necrosis. Uremia patients occasionally develop a condition, known as Acute Tubular Necrosis. In this ... Uremia Risk Factors. The risk of development of the disorder is increased by a number of factors. These risk factors include:. ...
Uraemia is a term which tends to be appied to describe the syndrome associated with an accumulation of all sorts of renally ... Uraemia is a term which tends to be appied to describe the syndrome associated with an accumulation of all sorts of renally ... The clinical manifeststaions of uraemia are of course the consequence of the accumulation of numerous different uraemic toxins ... Carbamoylation of amino acids and proteins in uremia. Kidney International 59 (2001): S102-S107. ...
... uremia is the later period. Preventing uremia need to a integral plan: all ki ... ... How to prevent uremia effectively All kinds of chronic kidney disease running to the later period can cause renal function ... uremia complications renal ultrasound different One Belt And One Road symptoms of kidney cancer food for kidney stone ... terminal uremia Atrophic Kidney signs of kidney disease in children medicine treatment analgesic kidney disease should you have ...
Uremia is a syndrome which arises as a direct consequence of complete loss of renal function and is the clinical end-point of ... When uremia arises, the rate of sodium excretion declines below that of daily sodium intake, resulting in build up of total ... Additional components of uremia arise because the highly dysfunctional kidneys can no longer secrete sufficient levels of ... Renal failure, acute or chronic, occurs due to a decline in Glomerular Filtration Rate (GFR). Uremia arises when GFR is ...
Renin-angiotensin gene polymorphism in children with uremia and essential hypertension. Pediatric Nephrology. 2003 Feb 1;18(2): ... Renin-angiotensin gene polymorphism in children with uremia and essential hypertension. Ferenc Papp, Aaron L. Friedman, Csaba ... Renin-angiotensin gene polymorphism in children with uremia and essential hypertension. In: Pediatric Nephrology. 2003 ; Vol. ... Fingerprint Dive into the research topics of Renin-angiotensin gene polymorphism in children with uremia and essential ...
... more and more men suffering from uremia, harm the disease for men is great, so you know what the early symptoms of male uremia ... with it, only to understand the early symptoms of male uremia, is it po ... The early symptoms of male uremia:. First, sleepy, fatigue. This may be early symptoms of male uremia early performance, but ... Early symptoms of male uremia. With the improvement of living standards, more and more men suffering from uremia, harm the ...
Why patients with Uremia appear tic? And is tic a normal symptom for patients with uremia? Uremia experts said that uremia is ... Uremia experts said that uremia is not a single disease, but a poisoning syndrome due to the accumulation of metabolites and ... Why patients with Uremia appear tic? And is tic a normal symptom for patients with uremia? ... Treatment for Skin Itching Leg Restless And Sleep Problem in ESRD (Uremia) ...
Uremia. Uremia is a Greek word that means "urine in the blood". Uremia develops as the kidneys fail and are unable to remove ... There are many symptoms of uremia that occur as kidney function declines. Before severe uremia develops, treatments such as ...
Due to chronic uremia is a systemic multi-organ damage, so a wide variety of clinical manifestations: Water-electrolyte ... Due to chronic uremia is a systemic multi-organ damage, so a wide variety of clinical manifestations: Water-electrolyte ... What are the early symptoms of uremia How to prevent hypertension in patients with uremia How to become uremia hypertension ... What are the symptoms of chronic uremia?. Due to chronic uremia is a systemic multi-organ damage, so a wide variety of clinical ...
Reference: Sokolova V.E., Liubartseva L.A., Effect of flavonoids on aspects of nitrogen metabolism in experimental uremia, ... amide nitrogen was decreased in brain tissue after bilateral nephrectomy of rats causing development an experimental uremia; an ...
Chronic renal failure refers to all kinds of kidney diseases caused by slow progressive renal damage resulting in uremia and ... How To Prevent The Development of Chronic Kidney Disease Into Uremia. Chronic renal failure refers to all kinds of kidney ... How To Prevent The Development of Chronic Kidney Disease Into Uremia* *Chinese Medicine Help Relieve Creatinine 4.1 And Urea 99 ... diseases caused by slow progressive renal damage resulting in uremia and renal function loss, cause a series of clinical ...
A serious condition in which toxic waste products, normally excreted in the urine, build up in the blood; this is usually as a result of severe kidney disease or kidney failure ...
Uremia is the pathological manifestations of severe azotemia. There is no specific time for the onset of uremia for people with ... A detailed and accurate history and physical will help determine if uremia is acute or chronic. In the cases of acute uremia, ... Uremia is the condition of having "urea in the blood". Urea is one of the primary components of urine. It can be defined as an ... Both uremia and the uremic syndrome have been used interchangeably to denote a very high plasma urea concentration that is the ...
The term uremia, which literally means urine in the blood, was first used by Piorry to describe the clinical condition ... Uremia is a clinical syndrome associated with fluid, electrolyte, and hormone imbalances and metabolic abnormalities, which ... encoded search term (Uremia) and Uremia What to Read Next on Medscape ... Uremia Differential Diagnoses. Updated: May 27, 2020 * Author: A Brent Alper, Jr, MD, MPH; Chief Editor: Vecihi Batuman, MD, ...
Uremia definition, a condition resulting from the retention in the blood of constituents normally excreted in the urine. See ... uremia. in Medicine. uremia. n.. *The accumulation of urinary waste products in the blood.. .css-10rk44a{font-size:15px;line- ... Uremia is the most dreaded symptom and develops as a result of the retained toxins in the blood.. Dietetics for Nurses. Fairfax ... This may go on to a fatal attack of uremia; but fortunately, not commonly, far less so than in scarlet fever.. Preventable ...
The term uremia, which literally means urine in the blood, was first used by Piorry to describe the clinical condition ... Uremia is a clinical syndrome associated with fluid, electrolyte, and hormone imbalances and metabolic abnormalities, which ... encoded search term (Uremia) and Uremia What to Read Next on Medscape. Related Conditions and Diseases. * Chronic Kidney ... The prognosis for patients with uremia of ESRD is poor unless the uremia is treated with renal replacement therapy, such as ...
Verapamil Improves Defective Intestinal Calcium Absorption in Uremia. In: Massry S.G., Maschio G., Ritz E. (eds) Phosphate and ... reduced intestinal absorption of calcium suggests that renal lα-hydroxylase activity is relatively suppressed in early uremia ( ... substantial clinical and experimental evidence that this abnormality in intestinal absorption of calcium is secondary to uremia ...
Meyer TW, Hostetter TH (2007). "Uremia". N. Engl. J. Med. 357 (13): 1316-25. DOI:10.1056/NEJMra071313. PMID 17898101. Research ... Uremia is defined as "the illness accompanying kidney failure that cannot be explained by derangements in extracellular volume ... Spontaneous subdural hematomas are more frequent in patients with uremia, particularly if the BUN level is greater than 150-200 ... Alper AB Jr., Shenava RG, Young BA (2 October 2009), "Uremia", eMedicine. ...
Fluoride metabolism in uremia. Author: Nielsen E, Solomon N, Goodwin NJ, Siddhivarn N, Galonsky R, Taves D, Friedman EA. ...
Uremia is a Greek word used in English to describe the condition of a persons blood. Uremia is caused by urine products ... If those come over the normal filtration system of the kidneys then the condition is called uremia. People with chronic renal ... disease or acute renal failure are usually affected by uremia.. Physical signs, symptoms and laboratory findings[change , ... Retrieved from "https://simple.wikipedia.org/w/index.php?title=Uremia&oldid=5143233" ...
Uremia. Topic Overview. Uremia (uremic syndrome) is a serious complication of chronic kidney disease and acute kidney injury( ...
Make research projects and school reports about uraemia easy with credible articles from our FREE, online encyclopedia and ... uraemia (yoor-ee-miă) n. the presence of excessive amounts of urea and other nitrogenous waste compounds in the blood. This ... uraemia (path.) presence in the blood of urinary constituents. XIX. f. Gr. oûron urine + haîma blood.. ... uraemia •Grasmere • cashmere •Emyr, premier •macadamia, Mesopotamia •academia, anaemia (US anemia), Bohemia, Euphemia, ...
The pathogenesis of cachexia in patients with uremia is unknown. We tested the hypothesis that uremia-associated cachexia is ... Role of leptin and melanocortin signaling in uremia-associated cachexia. Wai Cheung,1 Pin X. Yu,1 Brian M. Little,1 Roger D. ... We found that uremia-associated cachexia was attenuated in leptin receptor-deficient (db/db) mice as well as in MC4-RKO mice, ... Guarnieri, G, Antonione, R, Biolo, G. Mechanisms of malnutrition in uremia. J. Ren. Nutr. 2003. 13:153-157. View this article ...
Uremia and HbA1c Measured by High-Performance Liquid Chromatography. Didier Chevenne, Michèle Fonfrède, Rolande Ducrocq, ... Uremia and HbA1c Measured by High-Performance Liquid Chromatography. Didier Chevenne, Michèle Fonfrède, Rolande Ducrocq, ... Uremia and HbA1c Measured by High-Performance Liquid Chromatography Message Subject (Your Name) has forwarded a page to you ...
A Note on the Tendon Reflexes in Uraemia Br Med J 1904; 1 :123 ... A Note on the Tendon Reflexes in Uraemia. Br Med J 1904; 1 doi ...
Uremia is associated with diverse, but incompletely understood metabolic disturbances. Metabolomic approaches permit higher ... New insights into uremia-induced alterations in metabolic pathways Curr Opin Nephrol Hypertens. 2011 Nov;20(6):593-8. doi: ... Recent efforts to apply this technology to study uremia have reinforced the common view that end-stage renal disease is a state ... Summary: Uremia is associated with diverse, but incompletely understood metabolic disturbances. Metabolomic approaches permit ...
Clonazepam: effective treatment for restless legs syndrome in uraemia Br Med J (Clin Res Ed) 1982; 284 :666 ... Clonazepam: effective treatment for restless legs syndrome in uraemia. Br Med J (Clin Res Ed) 1982; 284 doi: https://doi.org/ ...
Germfree rats were used in 3 experiments to study the effects of the microbial flora on survival time after acute uremia ... THE ROLE OF THE MICROBIAL FLORA IN UREMIA. Albert Einheber, Darryl Carter ... of uremia or of starvation, and their survival times compared. To establish a limited defined flora in advance of nephrectomy, ...
Spasm to Uremia by Morris Fishbein. LibraryThing is a cataloging and social networking site for booklovers ...
... Mario Cozzolino ... Although VDR activation may mitigate the effects of uremia-induced arterial calcification, emerging data support a potential ... "Sevelamer hydrochloride attenuates kidney and cardiovascular calcifications in long-term experimental uremia," Kidney ...
Bone fluoride in patients with uremia maintained by chronic hemodialysis. Author: Kim D, Del Greco F, Hefferen JJ, Levin NW. ... There was no correlation between duration of uremia or number of dialyses and bone fluoride content. In 4 patients, 3 with ...
... Unstable atherosclerotic disease is related to systemic inflammation. ... interindividual variability in IL-10 production leads to distinct patient groups who can or cannot effectively limit the uremia ...
This presentation was given by Adeera Levin, ISN President. It was presented at the World Congress of Nephrology 2015 in Cape Town during Session 8: E...
Effect of medial calcification on vascular function in uremia. Roy L. Sutliff, Erik R. Walp, Alexander M El-Ali, Stacey ... Effect of medial calcification on vascular function in uremia. Roy L. Sutliff, Erik R. Walp, Alexander M El-Ali, Stacey ... Effect of medial calcification on vascular function in uremia Message Subject (Your Name) has sent you a message from Renal ...
... Madsen, Marie; Aarup, Annemarie; Albinsson, Sebastian LU ; ... Uremia}, language = {eng}, month = {02}, pages = {64--70}, publisher = {Elsevier}, series = {Atherosclerosis}, title = {Uremia ... Phenotypic modulation, Smooth muscle cells, Uremia. in Atherosclerosis. volume. 257. pages. 64 - 70. publisher. Elsevier. ... Methods Moderate uremia was induced by 5/6 nephrectomy in apolipoprotein E knockout (ApoE-/-) and wildtype C57Bl/6 mice. Plasma ...
This graph shows the total number of publications written about "Uremia" by people in this website by year, and whether "Uremia ... "Uremia" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject Headings) ... Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms. ... Plasma immunoreactive beta-endorphin is elevated in uraemia. Clin Endocrinol (Oxf). 1983 May; 18(5):459-64. ...
  • There are many symptoms of uremia that occur as kidney function declines. (kidney.ca)
  • What are the symptoms of chronic uremia? (tcmwell.com)
  • Gastrointestinal mucosal abnormalities ranging from edema to ulceration occur in two thirds of patients dying of uremia. (nus.edu.sg)
  • Uremia patients have a pale facial appearance, which also helps in determining the presence of the condition. (primehealthchannel.com)
  • Uremia develops as the kidneys fail and are unable to remove wastes from the body. (kidney.ca)
  • Uraemia' is a term which tends to be appied to describe the syndrome associated with an accumulation of all sorts of renally cleared waste products, and is not necessarily referring to the accumulation of urea alone. (derangedphysiology.com)
  • Severe uremia is now a rare occurrence in most developed nations, and yet is still present in many countries of the world. (nih.gov)
  • We present the case of a young adult with severe uremia who, despite application of recommended measures, developed DDS and non-cardiogenic pulmonary edema. (nih.gov)
  • Before severe uremia develops, treatments such as dialysis and transplantation are usually needed. (kidney.ca)
  • Dialysis disequilibrium syndrome and other treatment complications of extreme uremia: a rare occurrence yet not vanished. (nih.gov)
  • The clinical manifeststaions of uraemia are of course the consequence of the accumulation of numerous different uraemic toxins. (derangedphysiology.com)
  • Uremia may also arise due to various other disorders, which lead to reduced flow of blood or low blood volume. (primehealthchannel.com)
  • 1. The effect of uraemia on the rates of protein synthesis and protein degradation in liver, heart and vastus lateralis muscle were examined in the rat. (portlandpress.com)
  • Uraemia was induced by a five-sixths nephrectomy and the rates of protein turnover were compared with pair-fed sham-operated littermate controls. (portlandpress.com)
  • 4. Uraemia reduced both protein synthesis and protein degradation. (portlandpress.com)
  • Without intervention via dialysis or kidney transplant, uremia due to renal failure will progress and cause stupor, coma and death. (wikipedia.org)
  • Educate patients and their families about dialysis to avoid the shock of emergent dialysis and the decreased quality of life that can occur with uremia. (medscape.com)
  • Dialysis disequilibrium syndrome and other treatment complications of extreme uremia: a rare occurrence yet not vanished. (nih.gov)
  • A high interindividual variability in IL-10 production leads to distinct patient groups who can or cannot effectively limit the uremia- and dialysis-induced inflammation. (ebscohost.com)
  • Effects of uraemia and dialysis modality on polymorphonuclear cell apoptosis and function. (thefreedictionary.com)
  • Arias, "B lymphopenia in uraemia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2," Nephrology Dialysis Transplantation, vol. (thefreedictionary.com)
  • Dialysis and primary kidney disease had minor effects on gene regulation, but uremia was the dominant influence in the changes observed. (biomedcentral.com)
  • Is it good to treat uremia on dialysis? (kidneytcm.org)
  • Who says uremia have to dialysis? (kidneytcm.org)
  • This report describes the activity of AMG 416 in two different rodent models of uremia, compared in each case to cinacalcet, an approved therapeutic for secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease on dialysis. (biomedcentral.com)
  • To be frankly, adequate dialysis means a lot for Uremia patient, although it cannot cure this disease totally, but it can help the patient have a better life. (kidney-treatment.org)
  • In recent years, due to the widespread application of dialysis therapy, so that patients with advanced uremia for 5 years to survive and maintain a certain number of labor. (shenbingzy.com)
  • Therefore, dialysis therapy is one of the effective methods for the treatment of advanced uremia. (shenbingzy.com)
  • Is There A Reverse For Uremia Patients With Dialysis? (tongshantanghospital.com)
  • Dialysis can not treat kidney disease and improve kidney function, so dialysis can not help uremia patients to have a longer and better life. (tongshantanghospital.com)
  • Before severe uremia develops, treatments such as dialysis and transplantation are usually needed. (kidney.ca)
  • Patients with uremia need to know their disease well, take treatment positively, stick to regular dialysis and regain confidence in life. (kidney-treatment.org)
  • Because uremia is mostly a consequence of kidney failure, its signs and symptoms often occur concomitantly with other signs and symptoms of kidney failure. (wikipedia.org)
  • Below is a table showing more of the principal signs and symptoms of uremia. (wikipedia.org)
  • Residual syndrome is a non-life-threatening disease which is displayed as toxic effects causing many of the same signs and symptoms that uremia displays. (wikipedia.org)
  • Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms. (umassmed.edu)
  • Presenting symptoms were of uraemia and some patients had past history of renal disease. (thefreedictionary.com)
  • Uremia refers to a variety of kidney disease leading to progressive irreversible renal dysfunction, until the loss of a series of symptoms and metabolic disorders composed of clinical syndrome. (kidneyhealthy.com)
  • With the improvement of living standards, more and more men suffering from uremia, harm the disease for men is great, so you know what the early symptoms of male uremia with it, only to understand the early symptoms of male uremia, is it possible to do timely treatment, below, we look at it. (kidneytcm.org)
  • This may be early symptoms of male uremia early performance, but the most likely to be ignored, because the cause of drowsiness, fatigue is indeed too many reasons. (kidneytcm.org)
  • These are the early symptoms of male uremia related to the introduction, I hope to help you. (kidneytcm.org)
  • 2, if there is a close observation of the early symptoms of uremia, such as fatigue, backache leg soft weakness, loss of appetite or nausea and vomiting and other gastrointestinal symptoms, and sallow complexion, pale tongue, pale lips, eyelids etc. anemia. (tongshantang.net)
  • 1.Drowsiness, fatigue is the earliest symptoms of uremia patients, but also the most easily overlooked,because there are many reasons cause drowsiness fatigue, if a little rest that symptoms will well, so are more likely to be ignored by people. (shenbingzy.com)
  • Closely observe whether there are early symptoms of uremia, such as fatigue, weakness of waist and legs, loss of appetite or nausea and vomiting and other gastrointestinal symptoms, as well as pale complexion, pale tongue, lips, pale eyelids and other anemia. (kidneyabc.com)
  • Urologists sometimes use the term azotemia to designate preclinical uremia-that is, rising levels of urea in the blood that have not yet reached a level at which they cause symptoms. (beltina.org)
  • uremia refers to kidney failure, toxins and excess wastes can not be eliminated out, which will build up in body to cause symptoms of poisoning. (tongshantanghospital.com)
  • The human body will produce a variety of symptoms, namely uremia. (shenbingzy.com)
  • It is caused by chronic kidney damage caused by a variety of diseases that gradually lose renal function, resulting in toxic metabolites in the body can not be excreted in vitro, water, electrolyte disorders, acid-base imbalance caused by a series of complete Body poisoning symptoms, so commonly known as uremia. (huaxiainstitute.com)
  • I will give you some information on the causes and symptoms of uremia as well as some possible Treatments. (hubpages.com)
  • There are many symptoms of uremia that occur as kidney function declines. (kidney.ca)
  • Many uremia patients usually appear the symptoms such as low appetite, vomiting, nausea and astriction, these symptoms would disappeared quickly through the traditional Chinese Medicine therapies. (blogspot.com)
  • What are the symptoms of chronic uremia? (tcmwell.com)
  • If you still have questions about the symptoms of uremia, you can leave a message below, we can discuss it together. (kidneyhope.com)
  • In the development of uremia that patients will have a series of symptoms? (kidney-healthy.com)
  • 3. Most patients will have dizziness, and the other symptoms, which is mainly caused by uremia affecting the nervous system of patients. (kidney-healthy.com)
  • Uremia manifests itself quietly, much like colon cancer, where the individual goes for years without any symptoms. (emmettwilsonbook.com)
  • The other symptoms of uremia are vomiting, loss of appetite/energy, sleeplessness/restless leg syndrome ("his legs might have twitched, while he was awake or asleep,") a terrible itching, and a metallic taste in the mouth, then paranoia and psychosis, all of which can coalesce fairly rapidly, she said. (emmettwilsonbook.com)
  • How should we prevent uremia? (kidneyabc.com)
  • 4. In China, most of patients take Micro-Chinese Medicine Osmotherapy to prevent uremia stage, various of chinese herbal medicines used in the therapy to improve blood circulations, promote the metabolism, expend blood vessels, which achieve to repair diseased cells and tissues for improving kidney functions in basically. (kidneyabc.com)
  • In the cases of acute uremia, causes may be identified and eliminated, leading to higher chance for recovery of normal renal function, if treated correctly. (wikipedia.org)
  • Germfree rats were used in 3 experiments to study the effects of the microbial flora on survival time after acute uremia produced by a one-stage bilateral nephrectomy. (rupress.org)
  • Acute uremia impairs small and large intestinal motility , probably due to uremic toxins and autonomic dysfunction. (bvsalud.org)
  • Increased electronegativity of high-density lipoprotein in uremia patients impairs its functional properties and is associated with the risk of coronary artery disease. (medscape.com)
  • Uremia usually develops only after the creatinine clearance falls to less than 10 mL/min, although some patients may be symptomatic at higher clearance levels, especially if renal failure develops acutely. (medscape.com)
  • Spontaneous subdural hematomas are more frequent in patients with uremia, particularly if the BUN level is greater than 150-200 mg/dL. (citizendium.org)
  • The pathogenesis of cachexia in patients with uremia is unknown. (jci.org)
  • To define more clearly the factors involved in carbohydrate metabolism in uremia, we studied blood glucose, plasma insulin, and plasma growth hormone responses after the intravenous injections of 25 g of glucose in 17 uremic patients and compared the results with those in 14 normal subjects and 16 patients with maturity-onset diabetes mellitus. (annals.org)
  • Criteria for the diagnosis of uraemia as a result of benign essential nephrosclerosis were established in a group of 12 patients, most of whom had a long history of inadequately treated hypertension, arteriosclerosis, cardiomegaly and mild proteinuria. (journals.co.za)
  • Ultimately, patients may develop uremia and kidney failure. (lexico.com)
  • 1 ) present an analysis of United Network for Organ Sharing (UNOS) Registry data on outcomes of simultaneous pancreas and kidney (SPK) primary transplants, done between 2000 and 2007, in patients who had uremia and were classified as having insulin-treated type 2 versus type 1 diabetes. (asnjournals.org)
  • Gastrointestinal mucosal abnormalities ranging from edema to ulceration occur in two thirds of patients dying of uremia. (nus.edu.sg)
  • Uremia patients have a pale facial appearance, which also helps in determining the presence of the condition. (primehealthchannel.com)
  • Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors. (semanticscholar.org)
  • There is recent evidence that coronary artery calcification is frequent in hemodialysis patients and it has been suggested that this increased incidence may be associated to uremia-related factors. (semanticscholar.org)
  • Besides uraemia , metabolic acidosis and fluid and electrolyte imbalances, patients also suffer from physiological stress e.g. (thefreedictionary.com)
  • What are the reasons for the occurrence of uremia, uremia is one of the diseases that affect our health, once the death is a lot of patients to face Fact。 However, in the face of such a disease, you do not worry, active and effective trea. (tongshanclinic.com)
  • For elderly patients with uremia diet should pay attention to balanced nutrition, and its food as varied and rich as possible. (kidneytcm.org)
  • Many people know that hypertensive patients prone to stroke, in fact, hypertension and uremia is also very close relationship. (tongshantang.net)
  • 3, all patients with endogenous creatinine clearance rate reduction, serum creatinine and urea nitrogen elevation should be treated in accordance with the early treatment of uremia in a timely manner. (tongshantang.net)
  • The same goes to patients with Uremia, because those patients always have renal anemia. (blogspot.com)
  • This is enough to say that uremia has created a shadow to many patients. (ckdstage.com)
  • Patients with reduced endogenous creatinine clearance, elevated serum creatinine and urea nitrogen should be treated in time according to the early treatment of uremia. (kidneyabc.com)
  • Lots of toxins and excess wastes will cause high creatinine level , so what are the creatinine level of uremia patients? (tongshantanghospital.com)
  • Uremia is the end stage of kidney failure, if creatinine level continues to go up that will threaten patients' lives. (tongshantanghospital.com)
  • Uremia patients should ensure adequate rest and good nutrition, do not engage in activities beyond strength and power. (shenbingzy.com)
  • Why patients with Uremia appear tic? (renaldiseases.org)
  • Patients with uremia produce less active vitamin D, so the calcium phosphorus balance is broken, the intestinal calcium absorption decreases, and the kidneys phosphorus output decrease. (renaldiseases.org)
  • There is no a reverse for uremia patients, what we can do are to control the illness conditions and improve life quality to live a longer and better life. (tongshantanghospital.com)
  • All kinds of infection and low immune system are the main reasons of death in uremia patients. (blogspot.com)
  • Although uremia patients are in the end stage of renal failure, patients also have about 5% to 15% kidney function which is the most important for uremia patient because it could help patients remove the water and toxin. (blogspot.com)
  • In Uremia stage patients commonly take Micro-Chinese Medicine Osmotherapy , this therapy is based on Traditional Chinese Medicine but used external. (kidney-healthy.com)
  • Now the incidence of uremia is very high, it will threaten patients' lives. (kidney-healthy.com)
  • 2. Many patients have high blood pressure, congestive heart failure, and end stage renal insufficiency, mainly due to the influence of uremia to the cardiovascular system. (kidney-healthy.com)
  • If those come over the normal filtration system of the kidneys then the condition is called uremia. (wikipedia.org)
  • If the kidneys fail, one of the first signs is the accumulation of urea and other nitrogenous waste in the blood - uraemia. (lexico.com)
  • As kidneys fail, the dog is at risk for uremia, the build-up of toxins in the bloodstream. (dailypuppy.com)
  • His kidneys can't process nitrogen, ammonia and other wastes so efficiently any longer, so they're retained in his bloodstream and tissues, leading to uremia. (dailypuppy.com)
  • If Barney's uremia is acute, the cause of his compromised kidneys will be addressed, as well as the effects of the uremia. (dailypuppy.com)
  • Uremia arises when GFR is extremely low, resulting in an inability of the kidneys to properly regulate electrolyte and water levels along with an inability to secrete sufficient amounts of metabolic waste products. (pathwaymedicine.org)
  • Additional components of uremia arise because the highly dysfunctional kidneys can no longer secrete sufficient levels of hormones. (pathwaymedicine.org)
  • Uremia is a serious condition in which nitrogenbased toxins such as urea and creatinine, the primary waste products of metabolism, accumulate in the blood because the kidneys are unable to filter them out and pass them from the body via the urine . (beltina.org)
  • Uremia develops as the kidneys fail and are unable to remove wastes from the body. (kidney.ca)
  • Kidneys had a way of 'adjusting' to the damage done, but ultimately, uremia can kill. (emmettwilsonbook.com)
  • Cilazapril delays progression of hypertension and uremia in rat polycystic kidney disease. (scienceopen.com)
  • treatment for kidney disease: Can Traditional Chinese Medicine Treat Uremia? (blogspot.com)
  • Can Traditional Chinese Medicine Treat Uremia? (blogspot.com)
  • So can traditional Chinese medicine treat uremia? (blogspot.com)
  • If you want to know more details about Chinese Medicine or want to treat Uremia effectively, you can send email to us, we will try our best to help you. (kidney-treatment.org)
  • Uremia is a result of almost all renal fibrosis, resulting in loss of renal function. (tongshanclinic.com)
  • In addition to the fluid, acid-base, and electrolytes imbalance due to the deprived renal function, accumulation of circulating toxins and waste products, in particular the nitrogenous waste products that are normally excreted into the urine, are the main manifestations of uremia. (thecardiologyadvisor.com)
  • Uraemia' is a term which tends to be appied to describe the syndrome associated with an accumulation of all sorts of renally cleared waste products, and is not necessarily referring to the accumulation of urea alone. (derangedphysiology.com)
  • The clinical manifeststaions of uraemia are of course the consequence of the accumulation of numerous different uraemic toxins. (derangedphysiology.com)
  • Uremia experts said that uremia is not a single disease, but a poisoning syndrome due to the accumulation of metabolites and other toxic substances in the body caused by Kidney Failure . (renaldiseases.org)
  • Hypertensive Nephropathy may eventually develop into renal insufficiency uremia if it is not treated effectively and systematically at an early stage. (kidneyabc.com)
  • The last stage is advanced stage of renal insufficiency(uremia). (blogspot.co.uk)
  • 65 years, systemic diseases ( uraemia , diabetes mellitus) etc. (thefreedictionary.com)
  • So, all kidney diseases should be paid attention to, timely standardized treatment, to prevent the occurrence of uremia critically ill. (tongshanclinic.com)
  • It is a long time from Kidney Diseases to Uremia. (blogspot.com)
  • Some people with kidney diseases are surprised at the news that they have been at the stage of Uremia, because they feel nothing bad in daily life. (blogspot.com)
  • Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum," Journal of the American Society of Nephrology , vol. 12, no. 10, pp. 2146-2157, 2001. (hindawi.com)
  • Classical signs of uremia are: progressive weakness and easy fatigue, loss of appetite due to nausea and vomiting, muscle atrophy, tremors, abnormal mental function, frequent shallow respiration and metabolic acidosis. (wikipedia.org)
  • Both uremia and the uremic syndrome have been used interchangeably to denote a very high plasma urea concentration that is the result of renal failure. (wikipedia.org)
  • Uremia is a clinical syndrome marked by elevated concentrations of urea in the blood and associated with fluid, electrolyte, and hormone imbalances and metabolic abnormalities, which develop in parallel with deterioration of renal function. (medscape.com)
  • Uremia (uremic syndrome) is a serious complication of chronic kidney disease and acute kidney injury (which used to be known as acute renal failure). (uwhealth.org)
  • However, despite extensive investigation of the biology of uremia, and the application of recent advances in proteomics technology to investigate the causality of this syndrome [ 7 ], the molecular understanding of the precise disturbances in the uremic syndrome remains incomplete. (biomedcentral.com)
  • Uremia is a clinical syndrome that usually evolves in parallel with deterioration of renal function. (thecardiologyadvisor.com)
  • Modern medicine thinks uremia is a series of complex syndrome which is caused by the disorder of internal biochemical process. (tongshanclinic.com)
  • Uremia is a syndrome which arises as a direct consequence of complete loss of renal function and is the clinical end-point of progressive acute or chronic renal failure. (pathwaymedicine.org)
  • Uremia is defined as "the illness accompanying kidney failure that cannot be explained by derangements in extracellular volume, inorganic ion concentrations, or lack of known renal synthetic products. (citizendium.org)
  • Stage 4 is the advanced stage of kidney failure, with gradually loss of renal functions it will slip into the last stage of kidney disease(which is known as Uremia). (kidney-treatment.org)
  • Uremia (chronic kidney failure). (emmettwilsonbook.com)
  • The results of this study suggest that elevated circulating levels of cytokines such as leptin may be an important cause of uremia-associated cachexia via signaling through the central melanocortin system. (jci.org)
  • Experts pointed out that the direct cause of uremia is half of all types of kidney disease is not timely treatment and the development of late results. (kidneyhealthy.com)
  • Metabolic acidosis, along with abnormal electrolyte levels, can be seen in advanced cases of uremia. (thecardiologyadvisor.com)
  • Manifestations of left ventricular disease are frequent and persistent in chronic uraemia, and are associated with high risks of heart failure and death. (oup.com)
  • Sokolova V.E., Liubartseva L.A., Effect of flavonoids on aspects of nitrogen metabolism in experimental uremia, Voprosy meditsinskoi khimii, 1979, vol: 25(4), 379-382. (msk.ru)
  • Uremia is the end stage of Renal Failure. (blogspot.com)
  • The four stages are compensation stage of renal insufficiency, discompensation stage of renal insufficiency, early stage of renal failure and advanced stage of renal failure (uremia). (blogspot.co.uk)
  • uraemia (yoor- ee -miă) n. the presence of excessive amounts of urea and other nitrogenous waste compounds in the blood. (encyclopedia.com)
  • Other causes include lung cancer, and metabolic disorders such as uremia , in which excess levels of urea and other nitrogenous waste products, which normally are excreted through the urine, appear in the cat's blood. (petmd.com)
  • People with kidney function below 50% (i.e. a glomerular filtration rate [GFR] between 50 and 60 mL) and 30 years of age may have uremia to a degree. (wikipedia.org)
  • This can lead to reduced glomerular blood flow, leading to reduced urine output (oliguria) and retention of waste products (uremia). (wikipedia.org)
  • Effects of uraemia and haemodialysis on neutrophil apoptosis and expression of apoptosis-related proteins. (thefreedictionary.com)
  • We tested the hypothesis that uremia-associated cachexia is caused by leptin signaling through the hypothalamic melanocortin receptor 4 (MC4-R). We performed either subtotal nephrectomy (N) or sham operations in WT, leptin receptor-deficient ( db/db ), and MC4-R knockout (MC4-RKO) mice. (jci.org)
  • Uraemia was induced by a five-sixths nephrectomy and the rates of protein turnover were compared with pair-fed sham-operated littermate controls. (portlandpress.com)
  • Methods Moderate uremia was induced by 5/6 nephrectomy in apolipoprotein E knockout (ApoE -/- ) and wildtype C57Bl/6 mice. (lu.se)
  • The normal creatinine level is 40-120umol/L. Serum creatinine is more than 707 that it will be diagnosed as uremia. (tongshantanghospital.com)
  • It is widely accepted that the primary mechanisms of abnormal hemostasis in uremia involve alterations in platelet-endothelial cell interaction and platelet-platelet interaction. (thecardiologyadvisor.com)
  • The conformational changes in the platelet GPIIb/IIIa receptors and the decreased GPIb receptors recognized in uremia reduce platelet adhesion to the vascular subendothelial wall, which is essential in maintaining normal hemostasis. (thecardiologyadvisor.com)
  • NAJIYAH is an Uremia(End Stage Renal Disease)patient and accompanied by many other complications. (kidney-treatment.org)
  • Serum uric acid levels were determined by specific and non-specific methods in uraemia in order to investigate the correlation between non-specific chromogen and serum urea level. (bmj.com)
  • 6. It is suggested that aldosterone may continue to play an important regulatory role in sodium homeostasis in uraemia and that renin concentrations are the major determinants of aldosterone production in uraemia. (clinsci.org)
  • When uremia arises, the rate of sodium excretion declines below that of daily sodium intake, resulting in build up of total body sodium. (pathwaymedicine.org)
  • Actually, it is they that neglect the early signs of Uremia , which usually undermine their health covertly. (blogspot.com)
  • There are four main signs indicating Uremia. (blogspot.com)