AnatomyChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Up-RegulationGene Expression ProfilingReverse Transcriptase Polymerase Chain ReactionRNA, MessengerOligonucleotide Array Sequence AnalysisGene Expression RegulationSignal TransductionGene ExpressionCells, CulturedCell Line, Tumor
Up-Regulation
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Gene Expression Profiling
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Reverse Transcriptase Polymerase Chain Reaction
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Oligonucleotide Array Sequence Analysis
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Gene Expression
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Cell Line, Tumor
A cell line derived from cultured tumor cells.

Separation of shoot and floral identity in Arabidopsis. (1/28952)

The overall morphology of an Arabidopsis plant depends on the behaviour of its meristems. Meristems derived from the shoot apex can develop into either shoots or flowers. The distinction between these alternative fates requires separation between the function of floral meristem identity genes and the function of an antagonistic group of genes, which includes TERMINAL FLOWER 1. We show that the activities of these genes are restricted to separate domains of the shoot apex by different mechanisms. Meristem identity genes, such as LEAFY, APETALA 1 and CAULIFLOWER, prevent TERMINAL FLOWER 1 transcription in floral meristems on the apex periphery. TERMINAL FLOWER 1, in turn, can inhibit the activity of meristem identity genes at the centre of the shoot apex in two ways; first by delaying their upregulation, and second, by preventing the meristem from responding to LEAFY or APETALA 1. We suggest that the wild-type pattern of TERMINAL FLOWER 1 and floral meristem identity gene expression depends on the relative timing of their upregulation.  (+info)

A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. (2/28952)

The Drosophila doublesex (dsx) gene encodes a transcription factor that mediates sex determination. We describe the characterization of a novel zebrafish zinc-finger gene, terra, which contains a DNA binding domain similar to that of the Drosophila dsx gene. However, unlike dsx, terra is transiently expressed in the presomitic mesoderm and newly formed somites. Expression of terra in presomitic mesoderm is restricted to cells that lack expression of MyoD. In vivo, terra expression is reduced by hedgehog but enhanced by BMP signals. Overexpression of terra induces rapid apoptosis both in vitro and in vivo, suggesting that a tight regulation of terra expression is required during embryogenesis. Terra has both human and mouse homologs and is specifically expressed in mouse somites. Taken together, our findings suggest that terra is a highly conserved protein that plays specific roles in early somitogenesis of vertebrates.  (+info)

CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts. (3/28952)

Primary fibroblasts are not efficiently transduced by subgroup C adenovirus (Ad) vectors because they express low levels of the high-affinity Coxsackie virus and adenovirus receptor (CAR). In the present study, we have used primary human dermal fibroblasts as a model to explore strategies by which Ad vectors can be designed to enter cells deficient in CAR. Using an Ad vector expressing the human CAR cDNA (AdCAR) at high multiplicity of infection, primary fibroblasts were converted from being CAR deficient to CAR sufficient. Efficiency of subsequent gene transfer by standard Ad5-based vectors and Ad5-based vectors with alterations in penton and fiber was evaluated. Marked enhancement of binding and transgene expression by standard Ad5 vectors was achieved in CAR-sufficient fibroblasts. Expression by AdDeltaRGDbetagal, an Ad5-based vector lacking the arginine-glycine-aspartate (RGD) alphaV integrin recognition site from its penton base, was achieved in CAR-sufficient, but not CAR-deficient, cells. Fiber-altered Ad5-based vectors, including (a) AdF(pK7)betagal (bearing seven lysines on the end of fiber) (b) AdF(RGD)betagal (bearing a high-affinity RGD sequence on the end of fiber), and (c) AdF9sK betagal (bearing a short fiber and Ad9 knob), demonstrated enhanced gene transfer in CAR-deficient fibroblasts, with no further enhancement in CAR-sufficient fibroblasts. Together, these observations demonstrate that CAR deficiency on Ad targets can be circumvented either by supplying CAR or by modifying the Ad fiber to bind to other cell-surface receptors.  (+info)

Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment. (4/28952)

Fas (CD95) and Fas ligand (CD95L) are an interacting receptor-ligand pair required for immune homeostasis. Lymphocyte activation results in the upregulation of Fas expression and the acquisition of sensitivity to FasL-mediated apoptosis. Although Fas upregulation is central to the preservation of immunologic tolerance, little is known about the molecular machinery underlying this process. To investigate the events involved in activation-induced Fas upregulation, we have examined mRNA accumulation, fas promoter activity, and protein expression in the Jurkat T-cell line treated with phorbol myristate acetate and ionomycin (P/I), pharmacological mimics of T-cell receptor activation. Although resting Jurkat cells express Fas, Fas mRNA was induced approximately 10-fold in 2 h upon P/I stimulation. Using sequential deletion mutants of the human fas promoter in transient transfection assays, we identified a 47-bp sequence (positions -306 to -260 relative to the ATG) required for activation-driven fas upregulation. Sequence analysis revealed the presence of a previously unrecognized composite binding site for both the Sp1 and NF-kappaB transcription factors at positions -295 to -286. Electrophoretic mobility shift assay (EMSA) and supershift analyses of this region documented constitutive binding of Sp1 in unactivated nuclear extracts and inducible binding of p50-p65 NF-kappaB heterodimers after P/I activation. Sp1 and NF-kappaB transcription factor binding was shown to be mutually exclusive by EMSA displacement studies with purified recombinant Sp1 and recombinant p50. The functional contribution of the kappaB-Sp1 composite site in P/I-inducible fas promoter activation was verified by using kappaB-Sp1 concatamers (-295 to -286) in a thymidine kinase promoter-driven reporter construct and native promoter constructs in Jurkat cells overexpressing IkappaB-alpha. Site-directed mutagenesis of the critical guanine nucleotides in the kappaB-Sp1 element documented the essential role of this site in activation-dependent fas promoter induction.  (+info)

Downregulation of metallothionein-IIA expression occurs at immortalization. (5/28952)

Metallothioneins (MTs) may modulate a variety of cellular processes by regulating the activity of zinc-binding proteins. These proteins have been implicated in cell growth regulation, and their expression is abnormal in some tumors. In particular, MT-IIA is expressed 27-fold less in human colorectal tumors and tumor cell lines compared with normal tissue (Zhang et al., 1997). Here we demonstrate that MT-IIA downregulation occurs when human cells become immortal, a key event in tumorigenesis. After immortalization MT-IIA expression remains inducible but the basal activity of the MT-IIA promoter is decreased. MT-IIA downregulation at immortalization is one of the most common immortalization-related changes identified to date, suggesting that MT-IIA has a role in this process.  (+info)

Establishment of an inducible expression system of chimeric MLL-LTG9 protein and inhibition of Hox a7, Hox b7 and Hox c9 expression by MLL-LTG9 in 32Dcl3 cells. (6/28952)

The MLL (HRX/ALL-1 gene is frequently disrupted in infantile leukemias and therapy-related leukemias and fused to various translocation partner genes. We previously showed that chimeric MLL proteins localize in the nuclei in a fashion similar to that of MLL protein even if the partner gene encodes a cytoplasmic protein and indicated the importance of the N-terminal portion of MLL common to various MLL translocations. This time we established an inducible expression system for chimeric MLL-LTG9 and truncated N-terminal MLL proteins (MLL-Zf(-)) in 32Dcl3 cells. By utilizing this system, we were able to show inhibition of Hox a7, Hox b7 and Hox c9 genes' expression by induced MLL-LTG9 and MLL-Zf(-). Up-regulation of Hox a7, Hox b7 and Hox c9 was observed when 32Dcl3 cells were cultured with granulocyte colony stimulating factor (G-CSF) in place of interleukin 3 and induction of MLL-LTG9 and MLL-Zf(-) was shown to suppress this upregulation. At the same time, expression of two mammalian Polycomb group genes, M33 and mel-18, which both reportedly affect Hox genes' expression, was not inhibited by MLL-LTG9 and MLL-Zf(-) induction. These results indicate that MLL has an important effect on the expression of at least some Hox genes in hematopoietic cells and suggest that inhibition of the proper expression of Hox genes by chimeric MLL proteins may dysregulate hematopoietic cell differentiation and proliferation, which then can lead to leukemogenesis.  (+info)

Thymic selection by a single MHC/peptide ligand: autoreactive T cells are low-affinity cells. (7/28952)

In H2-M- mice, the presence of a single peptide, CLIP, bound to MHC class II molecules generates a diverse repertoire of CD4+ cells. In these mice, typical self-peptides are not bound to class II molecules, with the result that a very high proportion of H2-M- CD4+ cells are responsive to the various peptides displayed on normal MHC-compatible APC. We show here, however, that such "self" reactivity is controlled by low-affinity CD4+ cells. These cells give spectacularly high proliferative responses but are virtually unreactive in certain other assays, e.g., skin graft rejection; responses to MHC alloantigens, by contrast, are intense in all assays. Possible explanations for why thymic selection directed to a single peptide curtails self specificity without affecting alloreactivity are discussed.  (+info)

Intracellular sodium modulates the expression of angiotensin II subtype 2 receptor in PC12W cells. (8/28952)

Although the angiotensin II subtype 2 receptor (AT2-R) is expressed abundantly in the adrenal medulla, its physiological significance has not yet been determined. To obtain fundamental knowledge of the regulation of AT2-R expression in the adrenal medulla, we investigated the effects of modulating several ion channels on AT2-R expression in PC12W cells. Experiments were performed after 24 hours of serum depletion under subconfluent conditions. After 48 hours of treatment with various agonists or antagonists, the receptor density and mRNA level of AT2-Rs were quantified by 125I-[Sar1, Ile8]angiotensin II binding and Northern blot analysis. Ouabain (10 to 100 nmol/L) and insulin (10 to 100 nmol/L) dose-dependently increased receptor density and mRNA level. Analysis of the binding characteristics revealed that the ouabain-dependent increase in AT2-R levels was due to an increase in binding capacity without a change in the Kd value. These increases were blocked by lowering the Na+ concentration in the medium. A low concentration of the sodium ionophore monensin (10 nmol/L), the K+-channel blocker quinidine (10 micromol/L), and the ATP-sensitive K+-channel blockers tolbutamide (100 micromol/L) and glybenclamide (10 micromol/L) also significantly increased receptor density, but the ATP-sensitive K+-channel agonist cromakalim (100 micromol/L) decreased receptor density significantly (P<0.01). Nifedipine (10 micromol/L) decreased basal receptor density and completely blocked the increase in receptor density caused by these agents. The increase in receptor density caused by an increase in intracellular Na+ was accompanied by an increase in mRNA level, whereas the ATP-sensitive K+-channel blockers did not change mRNA level. Nifedipine slightly decreased mRNA level. These results suggest that AT2-R expression is sensitively regulated by intracellular cation levels. The change in intracellular Na+ level transcriptionally regulates AT2-R expression, whereas the K+-channel blocker-dependent upregulation appears to be at least in part posttranslational.  (+info)

PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production | Science...PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production | Science...
These investigations identify PD-1 up-regulation as a critical mediator of human interstitial lung disease through increased IL-17A production via the STAT3 signaling pathway. Key investigations have implicated aberrant STAT3 signaling and TH17 cells in murine models of pulmonary fibrosis pathogenesis (9, 28, 29). Here, we report that PD-1 up-regulation on human TH17 cells creates not only an immunosuppressive microenvironment but also a profibrotic one. We demonstrate that IL-17A and TGF-β1 produced by PD-1+CD4+ T cells induce collagen-1 production from HLF, a process that can be impeded by PD-1 pathway blockade. Mechanistically, PD-1 pathway blockade or small-molecule inhibition of STAT3 results in reduced collagen production from HLF.. Immune dysfunction in CD4+ T cells secondary to PD-1 up-regulation in sarcoidosis subjects experiencing loss of pulmonary function has been noted (10). However, the observation of a profibrotic component to PD-1 up-regulation has not been previously described; ...
https://stm.sciencemag.org/content/10/460/eaar8356?ijkey=b02424144b1b09f030092f5e3d6d936383ca5bef&keytype2=tf_ipsecsha
Gene Upregulation/Overexpression - Biology-OnlineGene Upregulation/Overexpression - Biology-Online
Regarding your promoter question: yes, but its hard. if you put it there specially to have it expressed, then obviously you have an active promoter (unless youre utterly stupid). But there are plasmids that do not have promoters at all: they are only meant to make the bacteria copy the gene, not to express it. if you have the name of your plasmid, you can usually check with the manufacturer, they will have a map that will tell you what your promoter is. if its a viral promoter then youre all set. If its not, you dont really know unless you search the literature for it. Generally speaking though, a promoter WILL express your gene - thats what a promoter does. Its just that a lot of promoters arent active all the time. For example, the lac promoter is not active if the bacterium doesnt have a CAP protein ...
https://www.biology-online.org/biology-forum/viewtopic.php?t=15882
CIB1 Regulates Endothelial Cells and Ischemia-Induced Pathological and Adaptive Angiogenesis | Circulation ResearchCIB1 Regulates Endothelial Cells and Ischemia-Induced Pathological and Adaptive Angiogenesis | Circulation Research
CIB1 is an important regulatory molecule that is expressed in different tissue types and has various binding partners.11-14 However, the role of CIB1 in ECs has never been explored. In this study, we use in vitro, ex vivo, and in vivo complementary analyses to provide the first evidence describing the critical role of CIB1 in EC function and signaling, growth factor-induced angiogenesis, and ischemia-induced pathological and adaptive angiogenesis.. Recent evidence suggests that CIB1 contributes to important intracellular signaling mechanisms. For example, we previously demonstrated that CIB1 binds to and activates PAK1 in different cell types and that CIB1 depletion results in decreased PAK1 activation on adhesion to fibronectin.14 Furthermore, we previously observed a Cdc42-dependent upregulation of PAK1 activity in CIB1-depeletd rat embryo fibroblasts with extended adhesion to fibronectin.14 In agreement with this, we also observed significantly reduced adhesion-induced PAK1 activation in ...
http://circres.ahajournals.org/content/101/11/1185.long
INT204899 - wiki-pain
In this particular case, RU486 essentially prevented gene upregulation (Cd44, Stat1, Ch25h and Il1b) or downregulation (C1qa and Hexb) by LPS ...
http://gnteam.cs.manchester.ac.uk/demos/wiki-pain/vhosts/wikipaints/mediawiki-1.19.1/index.php/INT204899
More compact fragments displays article-translational processing and the output of a series of more compact biologically active...
Every single lane received equivalent quantities of protein and detection of GAPDH served as an additional loading manage. Up-regulation of hCG was observed in
http://www.egfrinhibitor.com/2017/02/27/more-compact-fragments-displays-article-translational-processing-and-the-output-of-a-series-of-more-compact-biologically-active-peptides/
Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasisExpression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis
Expression of interleukin-8 (IL-8) by human melanoma cells correlates with their metastatic potential. Moreover, UV-B irradiation of primary cutaneous melanoma cells induces IL-8 mRNA and protein production and increases both tumor growth and metastasis in nude mice. Although IL-8 has been shown to …
https://pubmed.ncbi.nlm.nih.gov/9327744/?dopt=Abstract
Biology-Online • View topic - Are tissues in the body capable of sensing pain?Biology-Online • View topic - Are tissues in the body capable of sensing pain?
actually the cause has to do with the adaptation of the eye to light. the darkness causes all the retinen in cone cells to associate with its opsin partner, leading to an increased sensitivity of the cell to intense light. When the light is turned on, it overwhelms the receptor. It takes a few minutes for the eye to adapt and to switch from rod cells to cone cells. I believe the term for this is receptor up-regulation ...
http://www.biology-online.org/biology-forum/post-94079.html
VISTA Upregulation May Promote Resistance to CTLA-4 Blockade | Cancer DiscoveryVISTA Upregulation May Promote Resistance to CTLA-4 Blockade | Cancer Discovery
Thank you for sharing this Cancer Discovery article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
http://cancerdiscovery.aacrjournals.org/content/early/2017/04/14/2159-8290.CD-RW2017-069.full
MicroRNAs Induced During Ischemic Preconditioning | StrokeMicroRNAs Induced During Ischemic Preconditioning | Stroke
In this study, we investigated the miRNA profile during IPC and identified the selective miRNA changes early after the IPC by comparison with normal and ISC brains. The 8 miRNAs selected in the IPC 3-hour group were categorized into 2 families of miRNAs: the miR-200 family (miR-200a, miR-200b, miR-200c, miR-141, and miR-429) and the miR-182 family (miR-182, miR-183, and miR-96). Among them, miR-200b, miR-200c, and miR-429 targeted PHD2 and had the best neuroprotective effect. Our data can be used for further researches into the IPC mechanism and can contribute to the development of neuroprotective miRNA therapeutics.. Several previous studies have investigated miRNAs as mediators of ischemic tissue damage. In the ischemia of cardiac myocytes, miR-199a is acutely downregulated as early as 30 minutes after ischemia, leading to rapid upregulation of its target HIF-1α,24 which suggests that the changes in miRNA in response to the ischemia seem to be very prompt. Given that the maximum ...
http://stroke.ahajournals.org/content/41/8/1646
Plus itPlus it
TF is overexpressed in many types of human cancers, and clinical studies have shown a correlation between the levels of TF expression and poor prognosis (22-25). Not only does TF expression occur in a wide spectrum of cancers, but also the level of expression in cancer cells is upregulated by 1,000-fold compared with the levels of normal cells that these cancer cells are derived from (26, 27). This drastic upregulation may, to some extent, be caused by the existence of common tumor microenvironmental stimuli, such as those responsible for TF upregulation during inflammation and hypoxia. Recently, it was shown that TF expression is under the direct control of oncogenic pathways activated by genetic mutations sustained by cancer cells (28). This is shown experimentally by the effect of several mutant oncogenes, including K-ras, EGFR, EGFRvIII, HER-2, and PML-RARa on TF transcription, translation, half-life, and encryption. The effect of these oncogenes was operative in colorectal, mammary, ...
http://cancerres.aacrjournals.org/content/71/20/6492
Insulin Receptor Upregulation | GreenMedInfo | Keyword | NaturalInsulin Receptor Upregulation | GreenMedInfo | Keyword | Natural
By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
https://www.greenmedinfo.com/keyword/insulin-receptor-upregulation
EuRBPDB
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008 ...
http://eurbpdb.syshospital.org/rbpvsDisease.php?ensgid=ENSG00000138646&species=Homo_sapiens
Up-regulation of MMP-13 by IL-1Ra siRNA.(A) MMP-13 mRNA | Open-iUp-regulation of MMP-13 by IL-1Ra siRNA.(A) MMP-13 mRNA | Open-i
Up-regulation of MMP-13 by IL-1Ra siRNA.(A) MMP-13 mRNA expression in IL-1Ra and control siRNA-transfected cells. The cells were cultured for 1, 3, 6, 12, and 2
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4608771_pone.0140942.g003&req=4
Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα...
Fingerprint Dive into the research topics of Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice. Together they form a unique fingerprint. ...
https://augusta.pure.elsevier.com/en/publications/conditional-expression-of-the-erbb2-oncogene-elicits-reversible-h/fingerprints/
EPA-induced translational up-regulation of reporter gen | Open-iEPA-induced translational up-regulation of reporter gen | Open-i
EPA-induced translational up-regulation of reporter genes fused to BRCA1 mRNAb 5′UTR is dependent on the presence of tandem uORFsThe plasmid encoding for F-lu
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4466658_oncotarget-06-6902-g006&req=4
Issues [7?], ER whorl formation has been observed upon experimental up-regulation of | FGFR/VEGFR inhibitor-vegfrinhibitor.com
Issues , ER whorl formation has been observed upon experimental up-regulation of a variety of membrane-anchored proteins such as cytochrome P450 , HMG-CoA
http://www.vegfrinhibitor.com/2017/08/03/issues-7-er-whorl-formation-has-been-observed-upon-experimental-up-regulation-of/
RegPhos
Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization ...
http://regphos.mbc.nctu.edu.tw/browse_kinase_detail.php?group=TKL&family=IRAK&subfamily=&kinase=IRAK2
Aqueous humor-borne factor upregulates Bcl-2 expression in corneal endothelial cells<...
TY - JOUR. T1 - Aqueous humor-borne factor upregulates Bcl-2 expression in corneal endothelial cells. AU - Li, Xiao Yan. AU - De Marco, Brendan M.. AU - Mayhew, Elizabeth S.. AU - Niederkorn, Jerry Y.. N1 - Funding Information: We thank Dr. Steven Wilson (Eye Institute, Cleveland Clinics Foundation, Cleveland, OH) for generously providing Bcl-2 and Bax cDNAs; Dr. Richard H. Scheuermann (UT Southwestern Medical Center, Dallas, TX) for kindly providing primers for amplification of APO-1 (Fas) and plasmid DNA with PCMV/ APO-1 inserts. This study was supported in part by NIH grant EY07641 and an unrestricted grant from Research to Prevent Blindness, Inc.. PY - 1998. Y1 - 1998. N2 - Purpose. To determine if factors present in the aqueous humor (AH) protect the corneal endothelium from apoptosis. Methods. Mouse and human corneal endothelial cells were cultured in vitro, and apoptosis was induced by nutrient deprivation. AH and supernatant from iris/ciliary body (I/CB) cell cultures were tested for ...
https://utsouthwestern.pure.elsevier.com/en/publications/aqueous-humor-borne-factor-upregulates-bcl-2-expression-in-cornea
Characterization of β-Adrenergic Mechanisms and their Interaction with Corticosteroids in Human Pulmonary FibroblastsCharacterization of β-Adrenergic Mechanisms and their Interaction with Corticosteroids in Human Pulmonary Fibroblasts
TGF-β induced a marked and long lasting down-regulation of β2-adrenoceptors mRNA (about 90 % within 6 hrs). Also corticosteroids (dexamethasone and budesonide) alone caused a marked and long lasting up-regulation of β2-adrenoceptors mRNA, but they were not able to prevent or oppose the TGF-β induced down-regulation. Exposure to β-adrenoceptors agonists resulted in a rapid (maximum effect within 1 h), but transient up-regulation of β2-adrenoceptors mRNA level. This effect was mimicked by forskolin, a direct activator of adenylyl cyclase. Furthermore, as β-adrenoceptors agonists-induced up-regulation of β2-adrenoceptors mRNA also in presence of CHX, but not in presence of actinomycin D, it can be concluded that a cAMP direct stimulation of the expression of the β2-adrenoceptors gene may be involved ...
https://bonndoc.ulb.uni-bonn.de/xmlui/handle/20.500.11811/6141
Plus itPlus it
We now know that colonic tumors increasingly express progastrins (PG) as they progress through hyperproliferative (Hp) / adenoma (Ad) / adenocarcinoma (AdCA) sequence. We and others have recently reported that autocrine PG up-regulates expression of stem-cell-markers DCLK1/CD44/LGR5 (Gastro, 2011; IJC, 2012). Two major isoforms of DCLK1 (DCLK1-S, DCLK1-L) have been reported in neuroprogenitor cells. The two isoforms were discovered to be similarly expressed in colonic epithelial cells. Regulatory effects of PG were examined on the two isoforms in normal/cancer cells. Specific primer sets were designed to amplify S and L transcripts using qRT-PCR. Colon cancer cells either expressed S (HCT-116) or both S and L forms (HT-29, DLD1). HEK293 cells were used as a model of non-transformed cells since they respond to PG, do not express autocrine PG, and are non-tumorogenic. PG significantly up-regulated both the transcripts in HEK293 cells. The L-isoform is transcribed by the 5 promoter of the gene ...
http://cancerres.aacrjournals.org/content/73/8_Supplement/4891
Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth...Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth...
A protective capacity of transforming growth factor-beta1 (TGF-beta1) against various insults inducing neurone cell death in vitro and in vivo has been well established. We have recently shown the rapid up-regulation and persistent expression of TGF-beta1 in surviving CA1 pyramidal cells after cereb …
https://pubmed.ncbi.nlm.nih.gov/11720783/?dopt=Abstract
Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8...Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8...
The tyrosine kinase receptors HER2 and HER3 play an important role in breast cancer. The HER2/HER3 heterodimer is a critical oncogenic unit associated with reduced relapse-free and decreased overall survival. While signaling cascades downstream of HER2 and HER3 have been studied extensively at the level of post-translational modification, little is known about the effects of HER2/HER3 overexpression and activation on gene expression in breast cancer. We have now defined the genetic landscape induced by activation of the HER2/HER3 unit in mammary cells, and have identified interleukin (IL)8 and CXCR1 as potential therapeutic targets for the treatment of HER2/HER3-overexpressing breast cancers. Three-dimensional (3D) cultures, invasion and migration assays were used to determine the effects of HER2 and HER3 co-expression and activation. Gene expression analysis was performed to identify the gene network induced by HER2/HER3 in 3D cultures. Bioinformatic analysis and neutralizing antibodies were used to
https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3329
05) These data obviously showed that upresgulation of miR-451 mi | HIF Signaling
05). These data obviously showed that upresgulation of miR-451 might effectively enhance the sensitivity of A549 cells to DDP. Figure 5 Effect of miR-451 upregulation on the in. vitro sensitivity of A549 cells to DDP. A. Effects of various concentrations (0, 5, 10, 15, 20 and 25 μg/ml) of DDP on cells (mock A549, A549/miR-NC or A549/miR-451) for 12 h assessed by MTT assay. B. Effects of 5 μg/ml DDP on cells (mock A549, A549/miR-NC or A549/miR-451) for varied time length (0, 12, 24, 36 and 48 h) evaluated by MTT assays. C. Effects of 5 μg/ml DDP on colony formation of cells (mock A549, A549/miR-NC or A549/miR-451). All experiments were performed in triplicate, * P < 0.05. Upregulation of miR-451 enhances DDP-induced apoptosis of A549 cells The precise underlying mechanisms by which upregulation selleck of miR-451 enhances chemosensitivity of A549 cells to DDP were further investigated. Then, the apoptosis was detected by flow cytometric assay. As shown in Figure 6A, the apoptotic rare of ...
https://hifsignaling.com/05-these-data-obviously-showed-that-upresgulation-of-mir-451-mi
30 years in 30 weeks, 200630 years in 30 weeks, 2006
A major challenge in the HIV field has been to understand why the strength of virus-specific CD8 T cell responses has no relationship to viral load, and yet CD8 depletion studies indicate that these cells are critical for immune control. And a major challenge in the field of immunology in general has been the rapid translation of advances in murine models to humans. In late 2005, through a telephone conversation with Rafi Ahmed, we became aware of yet unpublished data in the mouse model of chronic infection. His laboratory had shown that in mice persistently infected with LCMV, T cells up-regulate a surface molecule termed PD-1, for programmed death-1, a negative immunoregulatory molecule that turned off CD8 T cell function. The potential parallels with HIV were immediately obvious to us-perhaps persistent exposure to HIV was having a similar impact on CD8 T cell function in humans, and perhaps similar immune regulation was rendering CD4 T cells exhausted as well.. We immediately formed a ...
http://www.vaccineenterprise.org/print/708
INT122460 - wiki-pain
CONCLUSIONS: The stimulation of occlusal trauma upregulates expressions of PN(3) mRNA and NaN mRNA, which suggests the signal occurring and conduction of chronic pain by occlusal trauma have the same molecular mechanism of sodium channel as inflammatory pain. ...
http://gnteam.cs.manchester.ac.uk/demos/wiki-pain/vhosts/wikipaints/mediawiki-1.19.1/index.php/INT122460
ETB ReceptorsETB Receptors
PURPOSE and BACKGROUND Cancers cells grow without the vices of responses control systems, leading to increased tumor cell success. platelets, tumor cells up-regulated down-regulated and anti-apoptotic pro-apoptotic genetics, elevated the amount of cells in the activity of DNA and reduced the accurate amount in the quiescent stage, elevated phrase of cyclins, DNA fix MAPKs and …Read More. ...
http://researchhunt.com/category/etb-receptors/page/2/
DSpace at KOASAS: Browsing DSpaceDSpace at KOASAS: Browsing DSpace
JNK-mediated transcriptional upregulation of RhoB is critical for apoptosis of HCT-116 colon cancer cells by a novel diarylsulfonylurea derivative. Kim, Dong-Myung; Won, Misun; Chung, Chung-Sook; Kim, Semi; Yim, Hyeon Joo; Jung, Sang-Hun; Jeong, ShinWu, APOPTOSIS, v.15, no.12, pp.1540 - 1548, 2010- ...
https://dspace.kaist.ac.kr/browse?type=subject&sort_by=1&order=ASC&rpp=60&etal=7&value=SULOFENUR&starts_with=B
Phytoene Desaturase Is Localized Exclusively in the Chloroplast and Up-Regulated at the mRNA Level during Accumulation of...Phytoene Desaturase Is Localized Exclusively in the Chloroplast and Up-Regulated at the mRNA Level during Accumulation of...
In the present study we addressed the question of whether the biosynthesis of secondary carotenoids in H. pluvialisproceeds via an independent second pathway that operates outside the chloroplast, as the accumulation of the astaxanthin esters in cytosolic lipid vesicles might indicate. According to our data for PDS, we conclude that, at least for this relatively early biosynthetic step of carotenogenesis, no second cytosolic pathway exists and that higher biosynthetic activity is coupled to higher amounts of enzyme. Up-regulation on both the mRNA and protein levels was observed upon induction of SC synthesis. Because of slight variability in the extent of SC accumulation between parallels (Grünewald, 1997), we do not interpret the small difference between the maxima in PDS mRNA and protein levels as a sign for post-translational regulation events-at least the main part of up-regulation takes place at the mRNA level.. Bouvier et al. (1998) showed that pepper PDS mRNA increased under different ...
http://www.plantphysiol.org/content/122/4/1261.full
Regulation of the Chemokine Receptor CXCR4 by Hypoxia | JEMRegulation of the Chemokine Receptor CXCR4 by Hypoxia | JEM
Regulation of cell migration by changes in oxygen availability is a central event during the organization of host response in inflammatory and neoplastic diseases as it may influence leukocyte recruitment and activation, angiogenesis, and metastasis formation (16). Here, we report that Hyp mediates selective up-regulation of CXCR4 in different cell types, including mononuclear phagocytes (monocytes, MDMs, and TAMs), endothelial cells, and cancer cells, and demonstrate that oxygen levels act as an important regulator of CXCR4 receptor expression. Our data also indicate that HIF-1 activation is involved in the Hyp-dependent up-regulation of CXCR4 expression and that the Hyp-HIF-1-CXCR4 circuit may participate in pathophysiological mechanisms under several conditions, ranging from inflammation to tumor angiogenesis and metastasis.. In contrast to standard cell culture conditions, characterized by 20% oxygen concentration, cells in the human body are exposed to much lower oxygen concentrations, ...
http://jem.rupress.org/content/198/9/1391
New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor , revealed by combined proteomic and...New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor , revealed by combined proteomic and...
In Streptomyces coelicolor, bldA encodes the only tRNA for a rare leucine codon, UUA. This tRNA is unnecessary for growth, but is required for some aspects of secondary metabolism and morphological development. We describe a transcriptomic and proteomic analysis of the effects of deleting bldA on cellular processes during submerged culture: conditions relevant to the industrial production of antibiotics. At the end of rapid growth, a co-ordinated transient up-regulation of about 100 genes, including many for ribosomal proteins, was seen in the parent strain but not the ΔbldA mutant. Increased basal levels of the signal molecule ppGpp in the mutant strain may be responsible for this difference. Transcripts or proteins from a further 147 genes classified as bldA-influenced were mostly expressed late in culture in the wild-type, though others were significantly transcribed during exponential growth. Some were involved in the biosynthesis of seven secondary metabolites; and some have probable roles in
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-8-261
stress upregulates cytokines, raises PE risk? - Welcome to the Preeclampsia Foundationstress upregulates cytokines, raises PE risk? - Welcome to the Preeclampsia Foundation
That said, we should be careful in attributing adverse pregnancy outcomes due to preeclampsia in human pregnancy to maternal stress without clear data. The association opens the door for women to blame themselves for having too much stress in their lives and therefore being responsible for their bad outcome. A number of us have tried to find cytokine markers that would serve as markers or predictors of preeclampsia - without much success. There are may be some statistical associations - but the overlap in data point is usually very large ...
http://preeclampsia.org/forum/viewtopic.php?f=19&t=22128&p=240120
Tiszlavicz László - ODT Személyi adatlapTiszlavicz László - ODT Személyi adatlap
Varga ZV, Kupai K, Szucs G, Gaspar R, Paloczi J, Farago N, Zvara A, Puskas LG, Razga Z, Tiszlavicz L, Bencsik P, Gorbe A, Csonka C, Ferdinandy P, Csont T: MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart., JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 62: pp. 111-121 ...
https://doktori.hu/index.php?menuid=192&lang=HU&sz_ID=9757
Samit ADhyaSamit ADhya
RNA binding proteins (RBPs) can regulate the stability and/or translatability of messengerRNAs (mRNAs) throughinteractions with their 30-untranslated regions. However, individual mRNAs may be regulated simultaneously or successivelyby more than one RBP, as well as by Argonaute (AGO)-bound miRNAs; the coordination of these various influenceson an individual mRNA is therefore complex and not well studied. In this report we examine the roles of two RBPs thatbind to AU-rich elements (ARE) - AUF1 and HuR - in the stability and translation of cyclin D1 (Ccnd1) mRNA in ratmyoblasts transiting the G phase of the cell cycle, and their interactions with miRNAs. Knockdown (KD) of AUF1 resultedin (1) transient upregulation of the mRNA level as well as an advancement of translation onset time (TOT) from 6 to 5 hpost-serum addition, (2) loss of miRNA loading on AGO1 and AGO2 and (3) reduction in the level of AGO-1 and AGO-2bound mRNA. In contrast, KD of HuR had no effect on the mRNA level, or on the AGO-mRNA ...
https://www.ias.ac.in/listing/bibliography/jbsc/Samit_ADhya
SARS-CoV-2 protein ORF3a - Proteopedia, life in 3DSARS-CoV-2 protein ORF3a - Proteopedia, life in 3D
Open Reading Frame 3a (ORF3a) Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination.[1][2] ...
http://proteopedia.org/wiki/index.php/SARS-CoV-2_protein_ORF3a
Downloadable Document - Superoxide Dismutase Up-regulationDownloadable Document - Superoxide Dismutase Up-regulation
This downloadable document (GMI PUB) is filled with medically researched knowledge, relevant information and pertinent data on Superoxide Dismutase Up-regulation. The GMI PUB contains 415 abstracts which consists of a Cumulative Knowledge * of 1039. This GMI PUB document will greatly reduce your research time due to the Cumulative Knowledge feature, and contains a condensed form of the studies that we have accumulated on Superoxide Dismutase Up-regulation.. ...
https://www.greenmedinfo.com/product/downloadable-document-superoxide-dismutase-regulation
TumorPortal
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments ...
http://www.tumorportal.org/view?geneSymbol=HERC5
2013 May | SRC Signaling
An alternative essential proapoptotic protein, BAK, was not upregulated by lethal UVB doses in either early or late passage cells . BAK, in contrast to BAX, is not really acknowledged to be a transcriptional target of P. We then examined anti apoptotic proteins. BCL was downregulated by UVB in both early and late passage cells at h submit irradiation . No visible distinction was observed among passage amounts. The scenario was quite different for BCL xL. As expected , BCL xL was quickly downregulated in youthful fibroblasts starting at h publish UVB. Strikingly, the basal BCL xL degree in outdated fibroblasts was instead rapidly upregulated following UVB and reached a plateau at h . BCLxL acts by antagonistically binding to pro apoptotic partners such as BAX. We for this reason quantitated the adjust in BAX BCL xL ratio among very low and high passage ranges . In youthful cells , this ratio increased fold h right after UVB however it was unchanged during the old cells . This end result displays ...
http://srcsignaling.com/2013/05
BioC] DESeq and number of replicates required for RNA-SeqBioC] DESeq and number of replicates required for RNA-Seq
Hi Naomi Thanks for the reply. The issue isnt necessarily low expressing genes, but perhaps high expressing genes with a small (ish) fold change. DESeq seems to only report as significant differences that are high fold changes. Contrast this to limma for microarrays, where small fold changes can be reported as significant. For whatever reason, the transcriptomic community have become fixated on two-fold as some kind of standard cut-off. Now, Im not fixated on that, but the example in DESeq reports 428 significant genes with an estimated fold change at FDR 5%, however, NONE of these are in the range -2 : 2. The minimum positive logFC is 2.18 (4.5 fold up-regulation), and the maximum negative logFC is 2.49 (5.65 fold down-regulation). So what I am concerned about is finding genes, either highly or lowly expressed, that are differing by a small fold change - say two-fold. Thanks Mick ________________________________________ From: Naomi Altman [naomi at stat.psu.edu] Sent: 14 June 2010 17:42 To: ...
https://stat.ethz.ch/pipermail/bioconductor/2010-June/033968.html
Plus itPlus it
Here we developed the new TS:YSOG3 reporter and used it along with TS:YSOG2 to characterize PKMζ and PKCλ turnover after cLTP induction in neurons. We found that PKMζ is upregulated following cLTP and that PKMζ copies produced after stimulation localized to synapses. We additionally demonstrated that the turnover of PKMζ copies synthesized after cLTP is more rapid than the turnover of basal PKMζ, both in the neuron cell body and in dendritic spines. These results held for PKMζ fused via its C terminus to TS:YSOG2. Furthermore, we demonstrated that PKCλ remains more stable at synapses than PKMζ and that its turnover is not altered after cLTP. We showed that our TS reporters not only allow identification of new copies of a given protein but also old copies as they degrade over time; this is possible because TS-tagged proteins synthesized during BILN application remain fused to irreversibly complemented YFP that stays stable after BILN washout. Moreover, fusion to TS did not affect PKMζ ...
http://www.jneurosci.org/content/35/20/7736
Meiotically up-regulated gene 99 protein elisa and antibodyMeiotically up-regulated gene 99 protein elisa and antibody
Shop Meiotically up-regulated gene 99 protein ELISA Kit, Recombinant Protein and Meiotically up-regulated gene 99 protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
https://www.mybiosource.com/protein_family.php?root=meiotically-up-regulated-gene-99-protein
Meiotically up-regulated gene 116 protein elisa and antibodyMeiotically up-regulated gene 116 protein elisa and antibody
Shop Meiotically up-regulated gene 116 protein ELISA Kit, Recombinant Protein and Meiotically up-regulated gene 116 protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
https://www.mybiosource.com/protein_family.php?root=meiotically-up-regulated-gene-116-protein
Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development...Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
https://oacentre.kennedy.ox.ac.uk/publications/108025
Genatlas sheet
strong evidence that transcriptional repression plays a major role in regulating GARAPL1/MAP1LC3A levels, and this up-regulation results in an increase in the size of the autophagosome ...
http://genatlas.medecine.univ-paris5.fr/fiche.php?onglet=5&n=21762
Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M...Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M...
Title:Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M Phase. VOLUME: 19 ISSUE: 3. Author(s):Karolina Królewska-Golińska, Marcin J. Cieślak*, Milena Sobczak, Rafał Dolot, Ewa Radzikowska-Cieciura, Mariola Napiórkowska, Iwona Wybrańska and Barbara Nawrot. Affiliation:Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, ...
https://www.eurekaselect.com/167679/article?tracking-code=4
Blood Pressure Control Goes Nuclear | Circulation ResearchBlood Pressure Control Goes Nuclear | Circulation Research
This unexpected set of observations led the investigators to explore a role for APE1 in regulation of nitric oxide synthase activity. Within the vascular endothelium, endothelial nitric oxide synthase (eNOS) activity is affected by levels of expression and also by well-characterized signaling pathways that activate eNOS. Expression of eNOS cannot be the major determinant of the hypertensive phenotype of APE1+/− mice, because eNOS levels are actually increased in the vessels of these mice in spite of their impaired ability to generate nitric oxide. The effect seems to be at the level of eNOS activation. Based on the data presented in this report it is reasonable to conclude that this is due in part to upregulation of H-Ras, which lies upstream of the phosphoinositide-3 kinase/Akt kinase pathway that potently activates eNOS.. The investigators conclude that increased Akt activation occurs via APE1-dependent upregulation of H-Ras expression, although the effect on H-Ras is modest and other ...
http://circres.ahajournals.org/content/95/9/849
Ectopic expression of a poplar APETALA3-like gene in tobacco causes early flowering and fast growth | Read by QxMDEctopic expression of a poplar APETALA3-like gene in tobacco causes early flowering and fast growth | Read by QxMD
A MADS-box gene, designated PtAP3, was isolated from a floral bud cDNA library derived from Populus tomentosa. Analysis by multiple alignments of both nucleotide and amino acid sequences, together with phylogenetic analysis, revealed that PtAP3 is an ortholog of Arabidopsis AP3. Analysis of RNA extracts from vegetative and reproductive tissues of P. tomentosa by RT-PCR indicated that PtAP3 is expressed in roots, stems, leaves and vegetative and floral buds. Notably, the expression of PtAP3 fluctuated during floral bud development between September and February with differences between male and female buds. In the former, a gradual down-regulation during this period, interrupted by a slight up-regulation in December, was followed by a sharper up-regulation on February. In developing female floral buds, expression was stable from September to November, sharply up-regulated in December, and then gradually down-regulated until February. The functional role of PtAP3 was investigated in transgenic ...
https://read.qxmd.com/read/21293905/ectopic-expression-of-a-poplar-apetala3-like-gene-in-tobacco-causes-early-flowering-and-fast-growth
Blimp1 and two naturally present dinucleotide repeats regulate the expression of mouse CS1 gene. (62.13) | The Journal of...Blimp1 and two naturally present dinucleotide repeats regulate the expression of mouse CS1 gene. (62.13) | The Journal of...
CS1 (CD319) is a member of the SLAM family of receptors, expressed on NK cells, T cells, B cells, DCs, etc. It induces NK cell cytotoxicity and is up regulated on B cell activation. CS1 is aberrantly up regulated on B cells in multiple myeloma and a therapeutic humanized anti-CS1 mAb HuLuc63 (Elotuzumab) is in Phase III of clinical trials. Recently, a unique population of CS1high B cells, implicated as major producers of pathogenic auto antibodies was detected in high SLE disease activity index (SLEDAI) patients. Regression analysis indicated direct correlation between the percentage of CS1high B cells and SLEDAI. With the available information on the pathogenic outcome of CS1 up-regulation on B cells, it is vital to study the molecular basis of CS1 expression. Here, we discuss the transcriptional regulation of mouse CS1 gene. According to our data, mouse CS1 promoter binds to Blimp1, mainly a trans-repressor and the master regulator of B cell maturation. Interestingly, mCS1 promoter also bears ...
http://www.jimmunol.org/content/186/1_Supplement/62.13
Plus itPlus it
FMRP has emerged as a central player in the regulation of protein synthesis-dependent synaptic plasticity. However, we know very little about how FMRP expression itself may be regulated as a function of neural activity in vivo, particularly during the time course over which major changes in synaptic reorganization occur. To address this question, we have determined the role of visual experience in regulating FMRP expression in the visual cortex of DR/LE rats. The most striking finding is that experience induces a rapid but transient expression of FMRP in this system. Furthermore, this transient upregulation of FMRP is observed in both dendrites and cell bodies and requires NMDA receptor activation. Our findings suggest that FMRP plays a dynamic role in experience-induced plasticity, especially during the first 15 min of synaptic reorganization.. We used both biochemical and immunohistochemical methods to study experience-dependent FMRP regulation. Immunolocalization revealed that, 15 min after ...
http://www.jneurosci.org/content/24/47/10579
Up-regulation of CD40 with juxtacrine activity in human nonsmall lung cancer cells correlates with poor prognosis - Ishikawa -...Up-regulation of CD40 with juxtacrine activity in human nonsmall lung cancer cells correlates with poor prognosis - Ishikawa -...
Ishikawa, K., Miyamoto, M., Yoshioka, T., Kato, T., Kaji, M., Ohbuchi, T., Hirano, S., Itoh, T., Dosaka-Akita, H. and Kondo, S. (2008), Up-regulation of CD40 with juxtacrine activity in human nonsmall lung cancer cells correlates with poor prognosis. Cancer, 113: 530-541. doi: 10.1002/cncr.23618 ...
http://onlinelibrary.wiley.com/doi/10.1002/cncr.23618/references
IL-25 « Karine SERRE, PhDIL-25 « Karine SERRE, PhD
Thus we questioned whether IL-4-producing CD8 T cells would be induced in vivo in response to primary immunization with alum-precipitated protein. The approach has been to compare the polarization of transgenic naïve ovalbumin-specific CD4 (OTII) and CD8 (OTI) T cells during their response to alum-precipitated ovalbumin (alumOVA). By addressing this question we have obtained further insight into the way early Th2-features are acquired by CD4 T cells in vivo in response to alum-precipitated protein.. Although both CD4 and CD8 OVA-specific T cells proliferate (30) in response to alumOVA, the acquisition of Th2-features, such as IL-4 and IL-13 mRNA up-regulation, is exclusively confined to CD4 T cells (Fig. 2). In addition, we confirm that mRNA specific for IL-17RB is strongly induced in vivo in alumOVA-responding OTII cells, but not in OTI cells responding to the same antigen (Fig. 2).. Conclusions. These findings indicate that the induction of IL-17RB expression is a selective feature of CD4 T ...
http://www.immunology.kserre.net/il-25/
Fortune. Derivatives: The Risk That Still Wont Go AwayFortune. Derivatives: The Risk That Still Wont Go Away
Fortune. Derivatives: The Risk That Still Wont Go Away. Washington wants to step up regulation of these complex instruments, hut new rules may not be enough to tame them. Volume 160, Number 1, July 06, 2009
https://www.you-books.com/book/Fortune/Derivatives-The-Risk-That-Still-Wont-Go-Away
the propranolol order uk
Propranolol order uk. This of course raises the question of what is repressed, and how this prлpranolol turn leads to the up-regulation of Snail and slug, which are also repressors.
http://thesiri.ru/generic-drugs/propranolol-order-uk.html
CCRL2抗体[MM0158-5A15]|Abcam中国|Anti-CCRL2抗体[MM0158-5A15]CCRL2抗体[MM0158-5A15]|Abcam中国|Anti-CCRL2抗体[MM0158-5A15]
CCRL2小鼠单克隆抗体[MM0158-5A15](ab89547)可与人样本反应并经Flow Cyt实验严格验证并得到5个独立的用户反馈。所有产品均提供质保服务，中国75%以上现货。
http://www.abcam.cn/ccrl2-antibody-mm0158-5a15-ab89547.html
Fair PlayFair Play
UEFA Financial Fair Play Regulations. *Fair Play (horse), an American Hall of Fame Thoroughbred racehorse ...
https://en.wikipedia.org/wiki/Fair_Play
Pharmaceutical policyPharmaceutical policy
Law and the regulation of medicines. Bloomsbury Publishing, 2012. p161-170 *^ Vogenberg, F. Randy, ed. Understanding Pharmacy ... For example, in the UK the Pharmaceutical Price Regulation Scheme is intended to ensure that the National Health Service is ...
https://en.wikipedia.org/wiki/Pharmaceutical_policy
Military recruitmentMilitary recruitment
"The Army Terms of Service Regulations 2007". www.legislation.gov.uk. Retrieved 2017-12-09.. ... "Queen's Regulations for the Army (1975, as amended)" (PDF). Retrieved 2017-12-09.. ...
https://en.wikipedia.org/wiki/Military_recruitment
Prevention through designPrevention through design
"Construction Design and Management Regulations 2015". www.hse.gov.uk. Retrieved 2017-04-19.. ... also known as CDM regulations in the UK). The concept supports this legal requirement.[12] Some Notified Bodies provide testing ... and design verification services to ensure compliance with the safety standards defined in regulation codes such as the ...
https://en.wikipedia.org/wiki/Prevention_through_design
Virginia State Route 267Virginia State Route 267
These regulations are enforced by the Virginia State Police. The Dulles Greenway is a privately owned toll road in Northern ... "HOT Lanes: A Better Way to Attack Urban Highway Congestion" (PDF). Regulation. Vol. 23, no. 1. p. 16. Archived from the ...
https://en.wikipedia.org/wiki/Virginia_State_Route_267
Patrick MichaelsPatrick Michaels
Regulation. Archived from the original (PDF) on February 15, 2007. Retrieved March 14, 2007. {{cite journal}}: Cite journal ...
https://en.wikipedia.org/wiki/Patrick_Michaels
Americans with Disabilities Act of 1990Americans with Disabilities Act of 1990
Public entities must comply with Title II regulations by the U.S. Department of Justice. These regulations cover access to all ... The EEOC developed regulations limiting an individual's impairment to one that "severely or significantly restricts" a major ... "Fact Sheet on the EEOC's Final Regulations Implementing the ADAAA". EEOC.gov. Archived from the original on September 12, 2014 ... Title II applies to public transportation provided by public entities through regulations by the U.S. Department of ...
https://en.wikipedia.org/wiki/Americans_with_Disabilities_Act_of_1990
Richard LindzenRichard Lindzen
Lindzen, Richard Siegmund (1992). "Global Warming: The Origin and Nature of the Alleged Scientific Consensus". Regulation. 15 ( ...
https://en.wikipedia.org/wiki/Richard_Lindzen
Prescription drug prices in the United StatesPrescription drug prices in the United States
Because the FDA has no regulations on drug companies in providing evidence that a new drug has a therapeutic advantage over an ... The National Bureau of Economic Research conducted a study in 2014 that found that price regulations significantly delayed the ... Regulation. Cato Institute. Jeanne Whalen (December 1, 2015). "Why the U.S. Pays More than Other Countries for Drugs". Wall ...
https://en.wikipedia.org/wiki/Prescription_drug_prices_in_the_United_States
Airport racial profiling in the United StatesAirport racial profiling in the United States
Mendenhall, G. Stuart; Mark Schmidhofer (December 2012). "Screening Tests for Terrorism" (PDF). Regulation. Feder, Jody. " ...
https://en.wikipedia.org/wiki/Airport_racial_profiling_in_the_United_States
Armen AlchianArmen Alchian
At RAND, he is remembered for his work on the hidden costs of regulation. Alchian was the first economist to be employed at ... Henderson, David R. (Summer 2012). "Up From Poverty" (PDF). Regulation. Cato Institute: 68. Archived from the original (PDF) on ...
https://en.wikipedia.org/wiki/Armen_Alchian
B.LeagueB.League
"Regulation". Japan Professional Basketball League. Retrieved 13 September 2020. "広島ライトニング、バスケの新リーグ参入への道、開かれず" [Road to new ... In line with Japan Basketball Association regulations, foreign citizens who were either born or raised in Japan and
https://en.wikipedia.org/wiki/B.League
Motor Carrier Act of 1980Motor Carrier Act of 1980
Consumers will benefit, because almost every product we purchase has been shipped by truck, and outmoded regulations have ... "Rail and Truck Reform: The Record So Far." Regulation. November/December 1988. Organization for Economic Cooperation and ... The MCA was envisioned to be a sweeping de-regulation of the trucking industry. When President Carter signed the bill, he ...
https://en.wikipedia.org/wiki/Motor_Carrier_Act_of_1980
Frank FitzsimmonsFrank Fitzsimmons
"Fitzsimmons Assails Bid to Cut Truck Regulations." New York Times. June 27, 1979; Moore, Thomas Gale. "Rail and Truck Reform: ... The Record So Far." Regulation. November/December 1988; Derthick, Martha and Quirk, Paul. The Politics of Deregulation. ...
https://en.wikipedia.org/wiki/Frank_Fitzsimmons
Library of Congress Classification:Class T -- TechnologyLibrary of Congress Classification:Class T -- Technology
Regulation. Flood control 540-558...................................Dams. Barrages 601-791................................... ...
https://en.wikipedia.org/wiki/Library_of_Congress_Classification:Class_T_--_Technology
New Zealand Veterinary Nursing AssociationNew Zealand Veterinary Nursing Association
The process of regulation of veterinary nurses coincides with the New Zealand government's review of veterinary nursing ... "Regulation". nzvna.org.nz. Retrieved 18 February 2016. "Animal Healthcare and Veterinary Nursing".{{cite web}}: CS1 maint: url- ... and Regulation. The NZVNA set recommended wage guidelines for veterinary nurses and veterinary nursing assistants. The NZVNA ...
https://en.wikipedia.org/wiki/New_Zealand_Veterinary_Nursing_Association
Assembly of TurkmenistanAssembly of Turkmenistan
Regulation; Science, education, culture and youth policy; Economic issues; Social policy; International and inter-parliamentary ...
https://en.wikipedia.org/wiki/Assembly_of_Turkmenistan
Spectrum commons theorySpectrum commons theory
The period without regulation only lasted a few years, but this concept guided Spectrum Commons Theory. In the 1950s, economist ... The early days of radio communication had no regulations, and everyone could use the spectrum without limitation. When a ... regulation was the source of extreme inefficiency. Economists since Coase have favored a market-based approach if there is ... Regulation. Cato Institute. p. 7. Brito, Jerry. "The Spectrum Commons in Theory and Practice" (PDF). Stanford Technology. ...
https://en.wikipedia.org/wiki/Spectrum_commons_theory
Precautionary principlePrecautionary principle
Thus, in the case of regulation of scientific research, there is a third party beyond the scientist and the regulator: the ... Strong precaution holds that regulation is required whenever there is a possible risk to health, safety, or the environment, ... 1996). "Is There a Role for Cost-Benefit Analysis in Environmental, Health, and Safety Regulation?". Science. 272 (5259): 221-2 ... and the regulation of genetically modified organisms".: 282-83 Through its application in case law, it has become a "general ...
https://en.wikipedia.org/wiki/Precautionary_principle
Metric fixationMetric fixation
Lemieux, P. (2018). "Government Fixation Is the Problem". Regulation. 41: 74. v t e (Management, Measurement, All stub articles ...
https://en.wikipedia.org/wiki/Metric_fixation
Right-to-work lawRight-to-work law
Holmes, Thomas (2000). "The Location of Industry: Do States' Policies Matter?" (PDF). Regulation. 50 (1): 47-50. Archived from ...
https://en.wikipedia.org/wiki/Right-to-work_law
Nebraska Board of Engineers and ArchitectsNebraska Board of Engineers and Architects
"Architecture and engineering; regulation". act No. 81-3401 of 2020. Nebraska Legislature. "The Nebraska Engineers and ... Robert Leroy Cochran, governor of Nebraska at the time, signed the Engineers and Architects Regulation Act into law. Cochran ... The Board also upholds and updates the Engineers and Architects Regulation Act which governors all laws related to architecture ...
https://en.wikipedia.org/wiki/Nebraska_Board_of_Engineers_and_Architects
CreosoteCreosote
... Council (2011). "Regulation". creosotecouncil.org/. Archived from the original on 2011-05-04. Delnao, Jack (March 1943 ... Hodson, E.R. (1906). Rules and Regulations for the Grading of Lumber. Government printing office. Howard, Phillip (February 28 ...
https://en.wikipedia.org/wiki/Creosote
Katrina WymanKatrina Wyman
Nelson, Robert H. (June 22, 2010). "Environmental policy memos to the president". Regulation. 33 (2): 55-59. Archived from the ...
https://en.wikipedia.org/wiki/Katrina_Wyman
Plain tobacco packagingPlain tobacco packaging
This regulation was supposed to enter into force on 10 April 2022, but entry was postponed to 1 January 2023 on April 1, 2022. ... These Regulations came into force on 14 March 2018 and since 6 June 2018, only standardised packages have been allowed for sale ... Legislation and associated regulations to enable standardised packaging of tobacco products came into force on 14 March 2018. ... "Tobacco Plain Packaging Regulations 2011". www.legislation.gov.au. "Slovenia passes law enforcing plain tobacco packaging from ...
https://en.wikipedia.org/wiki/Plain_tobacco_packaging
History of macroeconomic thoughtHistory of macroeconomic thought
ISBN 978-0-631-22573-7. Brannon, Ike (Spring 2006). "Remembering the Man Behind Rational Expectations". Regulation. 29 (1): 18- ...
https://en.wikipedia.org/wiki/History_of_macroeconomic_thought
Embedded inspectorEmbedded inspector
Examples include: Office for Nuclear Regulation British Transport Police Hughes, Peter (November 2017). "Legislative and ...
https://en.wikipedia.org/wiki/Embedded_inspector
Passive smokingPassive smoking
Concerns around secondhand smoke have played a central role in the debate over the harms and regulation of tobacco products. ... Harm to bystanders was perceived as a motivator for stricter regulation of tobacco products. Despite the industry's awareness ... Gori, Gio Batta (Spring 2007). "Stoking the Rigged Terror of Secondhand Smoke" (PDF). Regulation. 30 (1): 14-7. Archived from ... As part of its attempt to prevent or delay tighter regulation of smoking, the tobacco industry funded a number of scientific ...
https://en.wikipedia.org/wiki/Passive_smoking
E-governance in the United StatesE-governance in the United States
Regulation; Public Health Wilkesmann, Uwe (December 2013). "Effects of Transactional and Transformational Governance on ...
https://en.wikipedia.org/wiki/E-governance_in_the_United_States
Anti-discrimination lawAnti-discrimination law
Regulations 2003), age (the Employment Equality (Age) Regulations 2006), and religion/belief (Employment Equality (Religion or ... DeLeire, Thomas (2000). "The Unintended Consequences of the Americans with Disabilities Act". Regulation. 23. S2CID 8311722. ... Belief) Regulations 2003). In 2010, existing anti-discrimination law was combined into a single Act of Parliament, the Equality ...
https://en.wikipedia.org/wiki/Anti-discrimination_law
Space traffic management: Time for action - Atlantic CouncilSpace traffic management: Time for action - Atlantic Council
For example, the Federal Communications Commissions (FCCs) regulation of frequency licensing within the United States can be ... an international coordinating authority must first be empowered to promote dialogue and advance norms and regulations for ... has been slow to develop a common set of rules for-or understanding of-STM despite the urgent need to develop regulations and ... one avenue to incorporate industry in broader policy making discussions when an administration is preparing to issue regulation ...
https://www.atlanticcouncil.org/in-depth-research-reports/issue-brief/space-traffic-management-time-for-action/
https://ec.europa.eu/info/law/law-topic/data-protection enhttps://ec.europa.eu/info/law/law-topic/data-protection en
... reform of rules and the data protection regulation and directive. ... The General Data Protection Regulation (GDPR), the Data ... EU funding supporting the implementation of the General Data Protection Regulation (GDPR). EU Programmes financing projects on ... Staff Working Document: accompanying the Communication - two years of application of the General Data Protection Regulation ... New Data Protection Contractual Clauses based on Art 28 GDPR and Art 29 Regulation 2018/1725 ...
https://ec.europa.eu/info/law/law-topic/data-protection_en
Regulations and Reports | OSPI
State Regulations Washington Administrative Code (All WAC regulations) Search or Browse.For ... and regulations [WAC] RCW 28A (Common School Provisions) RCW 28A.400 (Employees) RCW 28A.405 (Certificated Employees) RCW 28A- ... Washington Administrative Code - State Regulations. Washington Administrative Code (All WAC regulations) Search or Browse.For ... Regulations and Reports RCWs, WACs, statistic reports, more... * Contact Information Certification office, Standards board, ...
https://www.k12.wa.us/certification/regulations-and-reports
View RuleView Rule
RIN Information URL: www.regulations.gov Public Comment URL: www.regulations.gov ... This rule sought public comment on a number of proposed changes to the EB-5 program regulations. Such proposed changes included ... In January 2017, the Department of Homeland Security (DHS) proposed to amend its regulations governing the employment-based, ... authorizes the Secretary to issue regulations. 8 U.S.C. 1103(a), INA section 103(a). INA section 203(b)(5), 8 U.S.C. 1153(b)(5 ...
https://www.reginfo.gov/public/do/eAgendaViewRule?pubId=201710&RIN=1615-AC07
StatutesStatutes
OG - Qualifying Regulations for Paris 2024 (ENG). Section 5.4.1.1. - OG - Qualifying Regulation for Paris 2024 (FRE). Section ... PG - Qualifying Regulations for Paris 2024. Section 5.4.3.2. - PG - Race to Paris 2024 Paralympic Ranking Regulations - updated ... Section 5.2 Tournament Regulations. Section 5.2.1. Major Events Tournament Regulations Table - updated 13 November 2022. ... YOG - Qualifying Regulations for Buenos Aires 2018. Section 5.4.2.2. - YOG - Regulations for Badminton Competition - Buenos ...
https://corporate.bwfbadminton.com/statutes/
Healthcare industry regulation | HostedHealthcare industry regulation | Hosted
Latest Healthcare industry regulation News. Bidens efforts to protect abortion access hit roadblocks. Dec. 06, 2022 12:28 PM ...
https://hosted.ap.org/dailycourier/tags/healthcare-industry-regulation
Business Costs & Regulation - page 9 | KiplingerBusiness Costs & Regulation - page 9 | Kiplinger
Regulation content can be found here. Find the latest news and gain more knowledge about Business Costs & Regulation. ... Business Costs & Regulation. All of Kiplingers Business Costs & Regulation content can be found here. Find the latest news and ... Business Costs & Regulation The Feds want to level the playing field between brokers and advisers. It may not make a difference ... Business Costs & Regulation Go ahead and check out our competition, they say, betting that you wont bother schlepping to ...
https://www.kiplinger.com/business-costs-regulation/page/9
Pharmaceuticals cheaper abroad because of regulation | CNNPharmaceuticals cheaper abroad because of regulation | CNN
The United States spends some of the lowest amounts of its total healthcare on prescription drugs relative to other developed nations. But Americans also pay some of the highest prices for those drugs, relative to the rest of the world.
https://edition.cnn.com/2015/09/28/health/us-pays-more-for-drugs/index.html
RegulationsRegulations
On the following pages, we have collected information on the respective regulations of the six departments concerning your ... achieving your doctoral degree at Technische Universität Braunschweig are determined by your departments doctoral regulations ...
https://www.tu-braunschweig.de/en/gradtubs/regulations
New Jersey Cottage Food Laws and Regulations: How to sell your homemade foods in New JerseyNew Jersey Cottage Food Laws and Regulations: How to sell your homemade foods in New Jersey
New Jersey Cottage Food Laws, Regulations and Facts. While New Jerseys state House passed a cottage food bill in mid 2014, one ... New Jersey Cottage Food Laws and Regulations: How to sell your homemade foods in New Jersey. PickYourOwn.org - Find a pick-your ... Looking for New Jersey Cottage Food Laws and Regulations: How to sell your homemade foods in New Jersey in 2022? Scroll down ... New Jersey Cottage Food Laws and Regulations: How to sell your homemade foods in New Jersey. ...
https://www.pickyourown.org/CottageFoodLaws-NewJersey.php
Better Regulation Victoria | Victorian GovernmentBetter Regulation Victoria | Victorian Government
Better Regulation Victoria. We work with the Victorian Government and the community to support the analysis, design and ... We support Anna Cronin in her dual roles as Commissioner for Better Regulation and Red Tape Commissioner. We also provide a ... Anna Cronin is Victorias first Commissioner for Better Regulation, appointed by the Victorian Government in 2015. She was ... Ask the Border Question when developing regulations. The Cross Border Commissioner supports Victorian Government agencies to ...
https://www.vic.gov.au/better-regulation-victoria
State Regulation of Coverage Options Outside the ACAState Regulation of Coverage Options Outside the ACA
Journal of Insurance Regulation, Fall 2005 24(1):31-45; and M. A. Hall, "The Geography of Insurance Regulation," Health Affairs ... Journal of Insurance Regulation, Fall 2005 24(1):31-45; M. A. Hall, "The Geography of Insurance Regulation," Health Affairs, ... State Regulation of Coverage Options Outside of the Affordable Care Act: Limiting the Risk to the Individual Market. ... Many of these are laid out in an NAIC model state law and model state regulation, adopted in 28 states.66 However, there are a ...
https://www.commonwealthfund.org/publications/fund-reports/2018/mar/state-regulation-coverage-options-outside-affordable-care-act
CFR - Code of Federal Regulations Title 21
For the most up-to-date version of CFR Title 21, go to the Electronic Code of Federal Regulations (eCFR). ...
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=872.6070
Medical Devices RegulationsMedical Devices Regulations
... (SOR/98-282). Full Document: *HTMLFull Document: Medical Devices Regulations (Accessibility Buttons ... Medical Devices Regulations. , a copy of the quality system certificate referred to in paragraph 32(2)(f), (3)(j) or (4)(p) of ... Medical Devices Regulations. , information in respect of a clinical study or investigational testing. , as defined in section ... Medical Devices Regulations. applies in respect of a designated medical device that was imported under the Exceptional ...
https://laws-lois.justice.gc.ca/eng/regulations/sor-98-282/rpdc.html
Environmental Information Regulations
How we comply with the Environmental Information Regulations 2004 ... provided a Guide to the Environmental Information Regulations ... To make an Environmental Information Regulations request, contact:. FOI Officer. Cranfield University. Cranfield. Bedfordshire ... and the full legislation of The Environmental Information Regulations 2004 is also available. ...
https://www.cranfield.ac.uk/about/governance-and-policies/policies-and-regulations/environmental-information-regulations
Hong Kong High Court Rules Mask Ban Regulation Incompatible With ConstitutionHong Kong High Court Rules Mask Ban Regulation Incompatible With Constitution
"The ERO, insofar as it empowers the CEIC [Chief Executive in Council] to make regulations on any occasion of public danger, is ... The judges added that they would convene a subsequent hearing on the question of relief in regards to the regulation, meaning ... MOSCOW (Sputnik) - Hong Kongs High Court ruled on Monday that the recently introduced regulation prohibiting residents from ... Hong Kong High Court Rules Mask Ban Regulation Incompatible With Constitution. In-Depth Coverage ...
https://www.globalsecurity.org/wmd/library/news/china/2019/china-191118-sputnik02.htm
CLIA Law & RegulationCLIA Law & Regulation
CLIA Regulations. Standards and Certification: Laboratory Requirements (42 CFR 493). Source: Government Printing Office (GPO) ... The final CLIA regulations were published in 1992, phased in through 1994, and amended in 1993, 1995, and 2003. Visit the CLIA ... The interpretive guidelines to the CLIA regulations are published in the CMS State Operations Manual (SOM). The SOM is used by ... The section of the federal regulations titled "Standards and Certification: Laboratory Requirements" is issued by the Centers ...
https://www.cdc.gov/clia/law-regulations.html
Broker Regulation in Forex TradingBroker Regulation in Forex Trading
Broker Regulation. The range of broker regulations around the globe is very wide. Some jurisdictions regulate every little ... regulation is lax. the customers are motivated to churn their accounts on their own. ... More relevant, some countries lump Forex into a broad category of "securities" regulation and do not break it out as a separate ... Some jurisdictions have a deliberate policy of lax regulation or low taxation in order to attract the brokerage industry, while ...
https://www.earnforex.com/forex-course/broker-regulation/
Cryptocurrency exchanges seek regulation to boost industrys credibility - The Globe and MailCryptocurrency exchanges seek regulation to boost industry's credibility - The Globe and Mail
However, regulations that are too onerous could have a negative effect, pushing innovation out of Canada and into more lenient ... "Its so easy to get into this market and its so easy to take advantage of the lack of regulation," Mr. Gokturk says. "The best ... Given the lack of regulation or transparency, industry insiders caution that customers may be falling prey to unethical or ... Several jurisdictions - including Australia and New York State - have already introduced regulations governing the online ...
https://www.theglobeandmail.com/business/article-cryptocurrency-exchanges-seek-regulation-to-boost-industrys/
Trapped in Haiti by airport security regulations - Foreign PolicyTrapped in Haiti by airport security regulations - Foreign Policy
Trapped in Haiti by airport security regulations. The Miami Heralds Douglas Hanks reports that U.S. commercial flights into ... Passport: Trapped in Haiti by airport security regulations Trapped in Haiti by airport security regul... ...
https://foreignpolicy.com/2010/01/19/trapped-in-haiti-by-airport-security-regulations/
Regulation Archives | CAPRegulation Archives | CAP
Posted in Exclusive CAP InsightsTagged Louisiana, Regulation, us, Affiliates, Sports Betting Assessing the Ontario Opportunity ... Posted in Exclusive CAP InsightsTagged Affiliates, Regulation, Sports Betting Will Overregulation Hurt Online Casino Market in ... Posted in Exclusive CAP Insights, Legal Updates,Online Casino News, Legal UpdatesTagged Affiliates, Regulation, Legal News, ...
https://www.casinoaffiliateprograms.com/blog/tag/regulation/
Petroleum Products Act: Regulations: AmendmentPetroleum Products Act: Regulations: Amendment
SECTION 25.30 GENERAL DEVELOPMENT REGULATIONSSECTION 25.30 GENERAL DEVELOPMENT REGULATIONS
B. General regulations. All fences shall comply with the following regulations:. 1. Location. No fence, wall, hedge, or other ... C. Regulations by land use. Except for as provided in Section B. above, the following regulations shall apply on developed lots ... D. Regulations for specific types of fences. The following regulations shall apply in all zoning districts:. 1. Fences on ... Where the Director determines there to be a conflict between these regulations and regulations specific to a zoning district, ...
https://www.codepublishing.com/CA/Fairfield/html/Fairfield25/Fairfield2510.html
IHF | Regulations DocumentsIHF | Regulations Documents
IHF Coaching Education Regulations IHF Coaching Education Regulations. The IHF has developed its online education platform http ...
https://www.ihf.info/regulations-documents/529?selected=IHF%20Coaching%20Education%20Regulations
CLIA Law & Regulation
CLIA Regulations. Standards and Certification: Laboratory Requirements (42 CFR 493). Source: Government Printing Office (GPO) ... The final CLIA regulations were published in 1992, phased in through 1994, and amended in 1993, 1995, and 2003. Visit the CLIA ... The interpretive guidelines to the CLIA regulations are published in the CMS State Operations Manual (SOM). The SOM is used by ... The section of the federal regulations titled "Standards and Certification: Laboratory Requirements" is issued by the Centers ...
http://wwwn.cdc.gov/clia/Regulatory/default.aspx
UNECE Regulation 108 - ETRMAUNECE Regulation 108 - ETRMA
Decide which cookies you want to allow. You can change these settings at any time. However, this can result in some functions no longer being available. For information on deleting the cookies, please consult your browsers help function. Learn more about the cookies we use ...
https://www.etrma.org/library/unece-regulation-108/
Lawyers - Attorney Regulation Counsel
Admissions Ceremony & Oath of Admission. The Office of Attorney Registration administers the Oath of Admission weekly via Zoom to pre-registered individuals who have been cleared for admission; these ceremonies are for On Motion, UBE Score Transfer, and Exam applicants. Do not come to our Office to take the Oath of Admission; the Office is not accepting walk-ins.. Procedures for Registering to Take the Oath of Admission and Required Documentation:. You must complete the online registration process to be assigned to an Admissions Ceremony. Do not register to take the Oath of Admission until you have been cleared for admission by the Attorney Admissions Office. Please do not come to our Office to register for a ceremony or to take the Oath of Admission in-person. If your Clearance Letter/Notice issued by the Office of Attorney Admissions is MORE than 90 days old from the date of issuance, you must fill-out and submit this Questionnaire at that time you register to take the Oath. Please submit the ...
https://coloradosupremecourt.com/Current%20Lawyers/NewlyAdmitted.asp
Regulation - Alabama Policy Institute
Regulation The power of the free market to create wealth seems to be rivaled only by the power of government regulation to ... The power of the free market to create wealth seems to be rivaled only by the power of government regulation to stifle it. ...
https://alabamapolicy.org/regulation/
FIA to address calls for WRC hybrid regulation changesFIA to address calls for WRC hybrid regulation changes
The FIA is set to take action in response to calls for regulation changes to prevent World Rally Championship entries being ... FIA to address calls for WRC hybrid regulation changes. The FIA is set to take action in response to calls for regulation ... But in a scary proposition for its rivals, the Japanese marque had built a car for the final year of the previous regulations ... Toyota and Hyundai have led calls for new Rally1 sporting regulations to be tweaked after issues with the control hybrid unit ...
https://www.autosport.com/wrc/news/fia-to-address-calls-for-wrc-hybrid-regulation-changes/9041457/
2022International Health ReguSearchContentLaws and RegulationsSelf-regulationEpigenetic regulationCentersStatutesLegislationCode of FederalGuidelinesBetter RegulationCHAPTERSystemic risk1992RulesClassificationAmendmentsOrdinanceGlobal regulationCustoms regulationsFinancial RegulationTobaccoEnvironmentalComplianceStrict regulationDigital regulationSimilar regulationTeachingStateEnforceRegulatoryGenesSectionApplyGuidance20192016ApplicableProvisionsReviseFederalProgrammeCouncilLegallyPolicyAmendmentGovernmentAdministersCaliforniaCommissionerConsiderablyGene expressionProceduresResearchImplementationPractice
20222
  • Regulations are current to 2023-01-25 and last amended on 2022-09-27. (gc.ca)
  • Regulations are current to 2022-11-16 and last amended on 2015-04-23. (gc.ca)
International Health Regu2
  • Organization (WHO) recognized the need to overhaul of preexisting systems and infrastructure, past and present international public health cooperation, and they revised objectives of health ministries and their external partners, the International Health Regulations (IHR). (cdc.gov)
  • On July 18, 2007, the revised International Health Regulations (IHRs) entered into effect for the United States. (cdc.gov)
Search2
  • Visit the CLIA Documents page to search and view the Federal Register Notices and former editions of the Code of Federal Regulations (published annually in October). (cdc.gov)
  • With it, the EU will pursue better regulation and the technology necessary to enforce, especially in regards to "very large online platforms (VLOPs) and very large online search engines (VLOSEs). (shacknews.com)
Content2
  • All of Kiplinger's Business Costs & Regulation content can be found here. (kiplinger.com)
  • But although voluntary agreements can be done right, more often Shadow Regulation is deliberately exclusive and opaque, resulting in private parties acting as the Internet police to enforce content removal or the restriction of online behavior, while elected governments avoid responsibility. (eff.org)
Laws and Regulations4
  • Regulations (as well as Executive Orders and Proclamations) are subordinate to laws but both laws and regulations are enforceable. (uscgboating.org)
  • Examine the laws and regulations from your own state or territory. (uscgboating.org)
  • Browse our collection of financial education materials, data tools, documentation of laws and regulations, information on important initiatives, and more. (fdic.gov)
  • Other federal financial agencies maintain their relevant banking laws and regulations on their own sites, which we link to below. (fdic.gov)
Self-regulation22
  • Children's self-regulation abilities are key predictors of educational success and other life outcomes such as income and health. (nature.com)
  • However, self-regulation is not a school subject, and knowledge about how to generate lasting improvements in self-regulation and academic achievements with easily scalable, low-cost interventions is still limited. (nature.com)
  • Here we report the results of a randomized controlled field study that integrates a short self-regulation teaching unit based on the concept of mental contrasting with implementation intentions into the school curriculum of first graders. (nature.com)
  • We demonstrate that the treatment increases children's skills in terms of impulse control and self-regulation while also generating lasting improvements in academic skills such as reading and monitoring careless mistakes. (nature.com)
  • Thus, self-regulation teaching can be integrated into the regular school curriculum at low cost, is easily scalable, and can substantially improve important abilities and children's educational career path. (nature.com)
  • Fig. 1: The effects of self-regulation teaching on reading and finding careless mistakes. (nature.com)
  • Fig. 2: The effects of self-regulation teaching on inhibition, attention and overall self-regulation. (nature.com)
  • Fig. 3: The long-term effects of self-regulation teaching on children's enrolment in advanced secondary school track. (nature.com)
  • McClelland, M. M. & Cameron, C. E. Self-regulation in early childhood: improving conceptual clarity and developing ecologically valid measures. (nature.com)
  • Zhou, Q., Chen, S. H. & Main, A. Commonalities and differences in the research on children's effortful control and executive function: a call for an integrated model of self-regulation. (nature.com)
  • Blair, C. & Raver, C. C. School readiness and self-regulation: a developmental psychobiological approach. (nature.com)
  • Is Self-Regulation Lost in Translation? (edweek.org)
  • Are self-regulation and grit about being able to independently set and focus on goals, or just about sitting still and being well-behaved in class? (edweek.org)
  • Author Elizabeth Weil takes a broad swipe at schools' increasing focus on self-regulation, social-emotional learning, theories of emotional intelligence, and "no excuses" charter schools, arguing that efforts to improve students' "grit" undermine creativity. (edweek.org)
  • From a research perspective, I'm not sure it's appropriate to lump everything related to social-emotional learning in general and self-regulation in particular into one bag, and Weil does little to make the case that self-regulation or grit impedes creativity (Some research finds the opposite . (edweek.org)
  • For me, Weil's personal experience points to a more interesting problem of how the somewhat technical terms of "self-regulation" and "grit" are translated into school language and policies. (edweek.org)
  • She's introduced to "self-regulation" during a conference with a teacher who wants Weil to put her 2nd grade daughter in occupational therapy to learn to sit still and raise her hand before speaking. (edweek.org)
  • Depending on who's defining it, self-regulation is the ability to focus attention on a task, to delay more immediate gratification in pursuing a longer term goal. (edweek.org)
  • Grit, as coined in 2007 by University of Pennsylvania psychologist Angela Duckworth, seems to combine self-regulation and persistence to involve "working strenuously toward challenges, maintaining effort and interest over years despite failure, adversity, and plateaus in progress. (edweek.org)
  • The contrast between the research definitions of self-regulation and grit and Weil's experience of them calls to mind a study by Princeton University researcher Joanne Wang Golan , previewed at the American Psychological Association meeting last month. (edweek.org)
  • Overall, Golann found the school's approach to teaching social-emotional skills led to orderly classrooms and students with good study and work habits associated with high self-regulation-but not the sort of autonomy, self-motivation, and goal-setting also associated with self-regulation and grit. (edweek.org)
  • The question at hand is whether self-regulation will improve or if regulatory intervention is inevitable. (darkreading.com)
Epigenetic regulation6
  • We discuss how these technologies have elucidated the development and epigenetic regulation of exhausted T cells and functional implications across viral infection, cancer, autoimmunity and engineered T cell therapies. (nih.gov)
  • The aim of our project was to better understand the epigenetic regulation of sex chromosomes during sperm differentiation and its impact on sperm development and male fertility. (europa.eu)
  • The long-term goal is to determine if abnormal epigenetic regulation of XY genes is at the basis of unexplained cases of human infertility. (europa.eu)
  • There, the MC fellow has developed her own research project, 'the study of the epigenetic regulation of XY genes during sperm differentiation' (see below for results) and has progressively become independent: she has now been recruited by Inserm, and leads her own team in the host group. (europa.eu)
  • We have demonstrated that Slx and Sly are both involved in the epigenetic regulation of XY gene expression during spermiogenesis, but with overall opposite effects: Slx is an activator while Sly is a repressor of XY gene expression. (europa.eu)
  • All these observations are in favour of a role of SSTY, together with SLY and SLX, in the epigenetic regulation of XY gene expression. (europa.eu)
Centers2
  • The section of the federal regulations titled "Standards and Certification: Laboratory Requirements" is issued by the Centers for Medicare & Medicaid Services (CMS) to enact the CLIA law passed by Congress (see below). (cdc.gov)
  • Vitamin D metabolism centers on kidney regulation of Cyp27b1 by mineralotropic hormones, including induction by parathyroid hormone (PTH), suppression by fibroblast growth factor 23 (FGF23) and 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), and reciprocal regulations for Cyp24a1 . (jbc.org)
Statutes2
  • The difference between laws (statutes) and regulations is sometimes misunderstood. (uscgboating.org)
  • This page compiles links to banking-related statutes, regulations, and similar material relevant to the work of the FDIC. (fdic.gov)
Legislation5
  • The Information Commissioner has provided a Guide to the Environmental Information Regulations and the full legislation of The Environmental Information Regulations 2004 is also available. (cranfield.ac.uk)
  • MAS establishes rules for financial institutions which are implemented through legislation, regulations, directions and notices. (mas.gov.sg)
  • It was written by Director of the Center for Free Enterprise Stephan Gohmann, PhD, and Johnson & Wales University Assistant Professor of Economics Adam C. Smith, PhD. "'Blue Laws' and Other Cases of Bootlegger/Baptist Influence in Beer Regulation" documents some of the strange bedfellows in lobbying for alcohol legislation. (louisville.edu)
  • Forty-three states have taken action toward newborn screening for CCHD through legislation, regulations, or hospital guidelines. (cdc.gov)
  • When states add conditions to their state-specific screening panels, they do so by state legislation, or rules and regulations ( 5 ). (cdc.gov)
Code of Federal3
  • and the Code of Federal Regulations is the official compilation of regulations. (uscgboating.org)
  • The Code of Federal Regulations (CFR) codifies the general and permanent rules of Executive departments and agencies which have been published in the Federal Register. (uscgboating.org)
  • Public involvement activities required under the State Air Quality Control Act (NMSA 1978 § 74-1-9), the Air Board's rulemaking procedures (20.11.82 NMAC) , and the Code of Federal Regulations (40 CFR §§ 51.100 to 51.105) must be completed prior to the submittal of any proposed plan or regulation to the Air Board or the EPA. (cabq.gov)
Guidelines7
  • This includes the BWF constitution, guidelines, policies, the code of ethics, codes of conduct, judicial procedures, laws of badminton and all technical regulations for the sport of badminton. (bwfbadminton.com)
  • The interpretive guidelines to the CLIA regulations are published in the CMS State Operations Manual (SOM). (cdc.gov)
  • Shadow Regulations are voluntary agreements between companies (sometimes described as codes, principles, standards, or guidelines) to regulate your use of the Internet, often without your knowledge. (eff.org)
  • After completing this section, you will be able to identify existing regulations and guidelines for TCE in the environment and in the workplace . (cdc.gov)
  • The federal government has developed regulations and guidelines for TCE to protect the public and workers from potential adverse health effects from exposure. (cdc.gov)
  • regulations and hospital guidelines were researched on state websites. (cdc.gov)
  • The international, national, and state regulations and guidelines regarding methylene chloride in air, water, and other media are summarized in Table 7-1. (cdc.gov)
Better Regulation4
  • Discusses a study conducted for the Local Better Regulation Office (LBRO) that evaluated the contribution of local authority regulatory services. (rand.org)
  • We support Anna Cronin in her dual roles as Commissioner for Better Regulation and Red Tape Commissioner. (vic.gov.au)
  • Anna Cronin is Victoria's first Commissioner for Better Regulation, appointed by the Victorian Government in 2015. (vic.gov.au)
  • The analysis of variance has shown that greater experience (and educational level) about one's own emotions and emotional reactions brings better regulation and control over negative emotions, and allow better differentiation among dimensions (factors). (srce.hr)
CHAPTER1
  • Prohibition's legacy is the subject of a chapter in Regulation and Economic Opportunity: Blueprints for Reform . (louisville.edu)
Systemic risk1
  • 1) Giving the Fed systemic risk regulation authority The Fed has, unsurprisingly, been talking up this idea for quite some time. (theatlantic.com)
19921
  • The final CLIA regulations were published in 1992, phased in through 1994, and amended in 1993, 1995, and 2003. (cdc.gov)
Rules8
  • Without Regulation M, the mutual fund company could potentially be subject to certain standard corporate tax rules which require it to pay taxes on capital gains . (investopedia.com)
  • Thus, the Air Quality Program, administered by the City of Albuquerque Environmental Health Department, and the Air Quality Control Board regulate air pollution in accordance with federal, state, and local rules and regulations. (cabq.gov)
  • For more information about the rules and regulations related to fresh and saltwater fishing licenses, please visit the Florida Fish and Wildlife Conservation Commission . (daytonabeach.com)
  • FDIC Rules and regulations are promulgated by the FDIC under its statutory authority and mandates. (fdic.gov)
  • The Digital Services Act has been agreed upon by the European Union Council and European Parliament, and with it, rules and regulations against digital activity both legal and illegal will be put into play. (shacknews.com)
  • While regulations will also affect startups, the rules are slightly more relaxed in on that matter in order to not stifle competition and development of new businesses. (shacknews.com)
  • You must complete the required CE per the Board's Rules and Regulations (see Section 9.0 ) within the two-year licensure period. (delaware.gov)
  • For more information about CE requirements and audits, click on the Continuing Education and Audit Information webpage or see Section 9.0 in the Nursing Rules and Regulations and Question 10 in the Frequently Asked Questions . (delaware.gov)
Classification2
  • In January 2017, the Department of Homeland Security (DHS) proposed to amend its regulations governing the employment-based, fifth preference (EB-5) immigrant investor classification. (reginfo.gov)
  • The Chemicals Regulation Division (CRD) is responsible for the regulation of biocides, pesticides, detergents, chemicals covered by REACH, and for compliance with the Classification, Labelling and Packaging (CLP) Regulation. (hse.gov.uk)
Amendments1
  • Newly installed Rally Director Andrew Wheatley has confirmed to Autosport that proposals formed to address Tanak's retirement will be discussed at Saturday's World Motor Sport Council, with amendments to regulations expected to be formerly announced. (autosport.com)
Ordinance2
  • Amid an escalation in civil unrest and violence in the city, the government in Hong Kong introduced in early October a Prohibition on Face Covering Regulation under the Emergency Regulations Ordinance (ERO), which banned residents from wearing face masks. (globalsecurity.org)
  • The provisions of this Section shall be applied in combination with other regulations in this Ordinance. (codepublishing.com)
Global regulation2
  • The World Health Organization (WHO) is calling for global regulation of electronic nicotine delivery devices - mainly, electronic cigarettes (e-cigarettes) - because current evidence suggests that the potential harms of these devices far outweigh any potential for good. (medscape.com)
  • Cite this: WHO Calls for Strict Global Regulation of e-Cigarettes - Medscape - Aug 27, 2014. (medscape.com)
Customs regulations1
  • From international trade law to customs regulations, trade compliance has risen to the top of the priority list among global importers and exporters. (joc.com)
Financial Regulation1
  • Obama has announced a sizeable overhaul of the structure of financial regulation in this country. (theatlantic.com)
Tobacco1
  • The Tobacco Control Regulations are intended to deal specifically with the packaging and labelling of tobacco products. (bvsalud.org)
Environmental4
  • Air quality regulation for the rest of the state is the responsibility of the New Mexico Environment Department and the state Environmental Improvement Board . (cabq.gov)
  • Management policies and regulations are in place that are designed to protect the recreational and environmental qualities of the lake and its ecosystem. (maryland.gov)
  • The Michigan Department of Environment, Great Lakes, and Energy (EGLE) has written the Michigan Guide to Environmental Regulations to assist Michigan's business, industry, and local governments in navigating the maze of environmental obligations they face. (michigan.gov)
  • Smart regulation : designing environmental policy / Neil Gunningham, Peter Grabosky, with Darren Sinclair. (who.int)
Compliance3
  • 28 (1) Subject to subsections (2) and (3), the Minister must reinstate an establishment licence if the establishment provides the Minister with sufficient evidence to demonstrate that it is in compliance with these Regulations. (gc.ca)
  • 2) The Minister may refuse to reinstate an establishment's licence if its compliance history demonstrates an inability to consistently conduct its activities in accordance with these Regulations. (gc.ca)
  • This guidebook is a ready-reference tool for anyone striving toward compliance with state and federal regulations that affect businesses and institutions. (michigan.gov)
Strict regulation2
  • Some jurisdictions have a deliberate policy of lax regulation or low taxation in order to attract the brokerage industry, while others have a deliberate policy of strict regulation and/or high taxation to keep the brokerage industry away. (earnforex.com)
  • The press release goes on to determine what separates VLOPs and VLOSEs from startups and small businesses that would be protected from strict regulation. (shacknews.com)
Digital regulation3
  • An agreement between the European Union Council and European Parliament is dedicating resources towards stronger digital regulation. (shacknews.com)
  • Under the provisional agreement by the EU Council and Parliament, the Digital Services Act (or DSA) can pursue better online and digital regulation. (shacknews.com)
  • Feedback and discussion on these issues will also inform the development of an overarching Digital Age Policy Framework, which provide principles, guidance and best practice that will inform the development of future digital regulation. (apo.org.au)
Similar regulation2
  • Nor has a similar regulation saved Spain from an enormous housing bubble, and a correspondingly enormous messy pop. (theatlantic.com)
  • Does the US need similar regulation? (shacknews.com)
Teaching1
  • The university-wide regulations concerning the MSc phase are presented in the Teaching & Examination Regulations (OER). (tudelft.nl)
State6
  • The SOM is used by state offices to administer various federal programs, such as clinical laboratory certification under the CLIA regulations, and enforced by CMS. (cdc.gov)
  • That is the original purpose of state regulation - to ensure the broker does not just steal the client's money. (earnforex.com)
  • Several jurisdictions - including Australia and New York State - have already introduced regulations governing the online marketplaces. (theglobeandmail.com)
  • Under New Mexico law , air quality regulation in the City of Albuquerque and Bernalillo County is the responsibility of local government rather than the state. (cabq.gov)
  • State Park Regulations COMAR .08.07 - The lake and buffer strip are part of Maryland's state park system. (maryland.gov)
  • After briefings from CDC on the need for state and local support to implement the revised IHRs, the Council of State and Territorial Epidemiologists on June 28, 2007, approved a resolution that the organization will support the new regulations (available at http://www.cste.org/ps/2007ps/2007psfinal/id/07-id-06.pdf ). (cdc.gov)
Enforce4
  • The Immigration Act (INA) authorizes the Secretary of Homeland Security (Secretary) to administer and enforce the immigration and nationality laws including establishing regulations deemed necessary to carry out his authority, and section 102 of the Homeland Security Act, 6 U.S.C. 112, authorizes the Secretary to issue regulations. (reginfo.gov)
  • Local Authority Regulatory Services (LARS), branches of local government that enforce national and often also European regulation at the local level, are required to demonstrate their value and impact, to shift towards an outcome focus and to ensure sufficient funding for their services. (rand.org)
  • The mission of FDA is to enforce laws enacted by the U.S. Congress and regulations established by the Agency to protect the consumer's health, safety, and pocketbook. (fda.gov)
  • In the past couple years, internet privacy and security has taken on exponential difficulty, especially as regulation and the technology to enforce it has failed to keep up. (shacknews.com)
Regulatory2
  • We also provide a 'regulatory help desk' for Victorian Government agencies, businesses and citizens to improve our regulation. (vic.gov.au)
  • MassDOT Highway Division Regulations will be amend during the Regulatory Review Process. (mass.gov)
Genes2
  • The process of turning genes on and off is known as gene regulation. (medlineplus.gov)
  • Although we know that the regulation of genes is critical for life, this complex process is not yet fully understood. (medlineplus.gov)
Section5
  • Regulation M is outlined in IRS tax code Title 26, beginning with Section 851. (investopedia.com)
  • 2) Section 62.32 of those Regulations applies to the holder of an establishment licence in respect of a designated medical device that they imported under that Interim Order. (gc.ca)
  • This Section provides standards and regulations applying to land uses in all zoning districts. (codepublishing.com)
  • Except for as provided in Section B. above, the following regulations shall apply on developed lots. (codepublishing.com)
  • You can see some examples of Shadow Regulation in the Blog section below, and in the interactive "Free Speech Weak Links" infographic linked in the sidebar. (eff.org)
Apply7
  • The conditions that apply for achieving your doctoral degree at Technische Universität Braunschweig are determined by your department's doctoral regulations. (tu-braunschweig.de)
  • Where the Director determines there to be a conflict between these regulations and regulations specific to a zoning district, the most restrictive regulation shall apply. (codepublishing.com)
  • The following regulations apply to the installation of fences, walls, and hedges. (codepublishing.com)
  • These regulations apply to the recreational use of the lake and buffer strip. (maryland.gov)
  • 1. This regulation shall apply to all introductory studies, undergraduate, taught postgraduate and research students. (lboro.ac.uk)
  • Use this tool to find which regulations apply to your specific operation. (michigan.gov)
  • These regulations specify the requirements that apply to individuals, businesses, and others. (cpsc.gov)
Guidance4
  • It is also a source of guidance to laboratories for interpreting the CLIA regulations. (cdc.gov)
  • Guidance and information on the UK implementation of the EC Detergents Regulation. (hse.gov.uk)
  • Analysis of the applicable laws, regulations, and guidance of the 50 states and the District of Columbia. (commonwealthfund.org)
  • Tavares pointed to Euro 7 regulations, and how regulators didn't follow expert guidance on how quickly the industry could respond and gave companies such a short timeline to comply. (wgntv.com)
20191
  • The regulations of BIGS-DR are applicable from September 6th, 2019 - the day of the announcement by the University of Bonn. (zef.de)
20161
  • That allows EPA to evaluate the intended use and to regulate prospective manufacturers or processors of TCE before the use occurs, provided that regulation is warranted under the act (NTP, 2016). (cdc.gov)
Applicable2
  • a copy of the quality system certificate referred to in paragraph 32(2)(f), (3)(j) or (4)(p) of those Regulations, as applicable. (gc.ca)
  • This reference tool is not intended to display every law and regulation applicable to insured depository institutions. (fdic.gov)
Provisions1
  • The effective withdrawal date for taught students shall be determined in accordance with the provisions of paragraph 40 of Regulation IX, and for research students shall be the date of last attendance as confirmed by the student's School. (lboro.ac.uk)
Revise1
  • Given the complexities involved in adjudicating benefit requests in the EB-5 program, along with continued program integrity concerns and increasing adjudication processing times, DHS has decided to revise the existing regulations to modernize key areas of the program. (reginfo.gov)
Federal4
  • Federal regulations are designed to protect workers, the public and the environment from unsafe or unfair business practices. (wsj.com)
  • Federal executive departments such as the Department of Homeland Security and administrative agencies such as the United States Coast Guard write regulations to implement the authority of laws. (uscgboating.org)
  • WASHINGTON (AP) - Federal Reserve Chair Jerome Powell said Tuesday that stablecoins will need greater regulation as they become more widely used by consumers. (ap.org)
  • The Board of Governors of the Federal Reserve System (FRS) has revised Regulation M, which implements the Consumer Leasing Act. (ncua.gov)
Programme1
  • 4. For the purpose of this regulation, tuition fees shall be taken to mean all fees that relate directly to the delivery and assessment of an academic programme of study or research. (lboro.ac.uk)
Council1
  • Building Regulations applications and payments are now processed by Erewash Borough Council on behalf of Mansfield District Council. (mansfield.gov.uk)
Legally2
  • Please Note: The Department has made every effort to ensure that the text of this regulation is identical to the official, legally effective version set forth in the New Jersey Register. (nj.gov)
  • To help prevent the spread of COVID-19 and help our country cope during the pandemic, CDC has occasionally issued legally binding orders and regulations. (cdc.gov)
Policy4
  • Business Costs & Regulation To avoid costly lawsuits, employers should adopt a zero tolerance policy. (kiplinger.com)
  • Thirteen scholars-whose backgrounds range from community organizing, to law, telecommunication, architecture, city planning, art, policy studies, and urban communication-examine public communication venues and opportunities, all of which are impacted by municipal regulation. (peterlang.com)
  • Whether it is the selective funding of public art, the establishment of architectural standards for public buildings, the regulation of signage, public assembly, food trucks, or telecommunication access, the authors in Urban Communication Regulation: Communication Freedoms and Limits contend that urban policy and regulation shape communication in cities. (peterlang.com)
  • Laws, regulations, administrative requirements, policies, or policy, and financing other government instruments in place are sufficient for implementation of obligations under IHR. (cdc.gov)
Amendment1
  • Time-Place-Manner Regulations: Is There a First Amendment Right to Busk? (peterlang.com)
Government7
  • Business Costs & Regulation Manufacturers worry that a new government information bank could become a gold mine of information for class action suits. (kiplinger.com)
  • We work with the Victorian Government and the community to support the analysis, design and implementation of best-practice regulation. (vic.gov.au)
  • According to research released last year from the Small Business Administration's Office of Advocacy, it costs about $2,830 more for firms with less than 20 employees than those with 500 or more employees to comply with government regulations on a per-employee basis. (wsj.com)
  • The judges argued that the restrictions that the mask ban imposes on fundamental rights "also go further than is reasonably necessary for the furtherance of those objects [the government proposed to pursue under the new regulation]. (globalsecurity.org)
  • Indeed, sometimes Shadow Regulation is even initiated by government officials, who offer companies the Hobson's choice of coming up with a "voluntary" solution, or submitting to government regulation. (eff.org)
  • The power of the free market to create wealth seems to be rivaled only by the power of government regulation to stifle it. (alabamapolicy.org)
  • Years of South African research and intersectoral interactions between government, academia, and industry culminated in successfully signed regulations. (who.int)
Administers1
  • CPSC also publishes regulations to implement the laws it administers and enforces. (cpsc.gov)
California4
  • In a Q&A session last week at CES, just after the reveal of the Ram 1500 Revolution BEV Concept -and a confirmation of the range-extended truck-Green Car Reports asked Stellantis CEO Carlos Tavares about how such a model fits in versus tighter new regulations from California and the EPA. (wgntv.com)
  • Our conversation is based on his study about California regulations on eating raw oysters, which appears in CDC's journal, Emerging Infectious Diseases . (cdc.gov)
  • Reginald Tucker] You did a study on the impact of a 2003 California regulation on selling raw oysters. (cdc.gov)
  • Duc Vugia] In April 2003, California implemented a regulation to not allow the sale in California of raw oysters harvested from the Gulf of Mexico between April and October unless they were treated or processed to reduce Vibrio vulnificus bacteria to non-detectable levels. (cdc.gov)
Commissioner1
  • Vere Murphy, Commissioner of the Free Trade Zone, explained that as the Internet continues to grow, regulation of cyber-gaming is necessary to protect consumers, to encourage responsible trade practices by operators, and to address issues such as compulsive gambling, restricted access by minors and money laundering. (casinocitytimes.com)
Considerably2
  • The new regulations require carriers to complete their advanced manifest submissions considerably prior to the vessel's arrival or departure. (joc.com)
  • The need for online regulation has grown considerably more important over the course of the last few years. (shacknews.com)
Gene expression1
  • Gene regulation can occur at any point during gene expression, but most commonly occurs at the level of transcription (when the information in a gene's DNA is passed to mRNA). (medlineplus.gov)
Procedures1
  • The Air Board process for considering new air quality regulations and plans is governed by the New Mexico Air Quality Control Act and by the Air Board's rulemaking procedures . (cabq.gov)
Research1
  • The National Human Genome Research Institute provides a definition of gene regulation in their Talking Glossary of Genetic Terms. (medlineplus.gov)
Implementation1
  • Information on how these regulations are implemented at AE can be found in the Implementation Regulations (UR). (tudelft.nl)
Practice1
  • Yet banking regulation is surprisingly not all that risk-sensitive in practice. (ssrn.com)