Turbinates
Rhinitis, Atrophic
Nasal Obstruction
Nasal Cavity
Nasal Mucosa
Nasal Septum
Otorhinolaryngologic Surgical Procedures
Nasal Polyps
Pasteurella multocida
Nose
Endoscopy
Pasteurella
Rhinitis, Vasomotor
Dermotoxins
Bordetella
Olfactory Mucosa
Ethmoid Bone
Ethmoid Sinus
Rhinitis, Allergic, Perennial
Pneumovirus
Cheirogaleidae
Skull Base
Contributory and exacerbating roles of gaseous ammonia and organic dust in the etiology of atrophic rhinitis. (1/191)
Pigs reared commercially indoors are exposed to air heavily contaminated with particulate and gaseous pollutants. Epidemiological surveys have shown an association between the levels of these pollutants and the severity of lesions associated with the upper respiratory tract disease of swine atrophic rhinitis. This study investigated the role of aerial pollutants in the etiology of atrophic rhinitis induced by Pasteurella multocida. Forty, 1-week-old Large White piglets were weaned and divided into eight groups designated A to H. The groups were housed in Rochester exposure chambers and continuously exposed to the following pollutants: ovalbumin (groups A and B), ammonia (groups C and D), ovalbumin plus ammonia (groups E and F), and unpolluted air (groups G and H). The concentrations of pollutants used were 20 mg m-3 total mass and 5 mg m-3 respirable mass for ovalbumin dust and 50 ppm for ammonia. One week after exposure commenced, the pigs in groups A, C, E, and G were infected with P. multocida type D by intranasal inoculation. After 4 weeks of exposure to pollutants, the pigs were killed and the extent of turbinate atrophy was assessed with a morphometric index (MI). Control pigs kept in clean air and not inoculated with P. multocida (group H) had normal turbinate morphology with a mean MI of 41.12% (standard deviation [SD], +/- 1. 59%). In contrast, exposure to pollutants in the absence of P. multocida (groups B, D, and F) induced mild turbinate atrophy with mean MIs of 49.65% (SD, +/-1.96%), 51.04% (SD, +/-2.06%), and 49.88% (SD, +/-3.51%), respectively. A similar level of atrophy was also evoked by inoculation with P. multocida in the absence of pollutants (group G), giving a mean MI of 50.77% (SD, +/-2.07%). However, when P. multocida inoculation was combined with pollutant exposure (groups A, C, and E) moderate to severe turbinate atrophy occurred with mean MIs of 64.93% (SD, +/-4.64%), 59.18% (SD, +/-2.79%), and 73.30% (SD, +/-3.19%), respectively. The severity of atrophy was greatest in pigs exposed simultaneously to dust and ammonia. At the end of the exposure period, higher numbers of P. multocida bacteria were isolated from the tonsils than from the nasal membrane, per gram of tissue. The severity of turbinate atrophy in inoculated pigs was proportional to the number of P. multocida bacteria isolated from tonsils (r2 = 0.909, P < 0.05) and nasal membrane (r2 = 0.628, P < 0.05). These findings indicate that aerial pollutants contribute to the severity of lesions associated with atrophic rhinitis by facilitating colonization of the pig's upper respiratory tract by P. multocida and also by directly evoking mild atrophy. (+info)Anatomical structure and surface epithelial distribution in the nasal cavity of the common cotton-eared marmoset (Callithrix jacchus). (2/191)
To validate use of the common cotton-eared marmoset (Callithrix jacchus) in inhalation toxicity studies, its nasal morphology was examined. The nasal turbinates each consisted of one maxilloturbinate and one ethmoturbinate: these were more planar in structure than the comparable structures of rodents or dogs. The nasal cavity epithelia comprised squamous epithelium (SE), nasal transitional epithelium (NTE), respiratory epithelium (RE) and olfactory epithelium (OE), listed in order of occurrence from anterior to posterior positions. NTE was distributed as a narrow band lying between SE and RE. OE was limited to the dorsal part of the cavity, which was structurally similar to that of the macaque or man. Overall, this study revealed structural the similarity of the whole nasal cavity in the marmoset to that of macaques or humans. Prediction of nasal cavity changes in man based on extrapolation from experimentally induced changes in the common marmoset therefore seems likely to be feasible, making it a useful animal model for inhalation studies. (+info)Chronic inhalation carcinogenicity study of commercial hexane solvent in F-344 rats and B6C3F1 mice. (3/191)
The carcinogenic and chronic toxicity potential of commercial hexane solvent was evaluated in F-344 rats and B6C3F1 mice (50/sex/concentration/species) exposed by inhalation for 6 h/day, 5 days/week for 2 years. Target hexane vapor concentrations were 0, 900, 3000, and 9000 ppm. There were no significant differences in survivorship between control and hexane-exposed groups, and clinical observations were generally unremarkable. Small, but statistically significant decreases in body weight gain were seen in rats of both sexes in the mid- and high-exposure groups and in high-expsoure female mice. The only noteworthy histopathological finding in rats was epithelial cell hyperplasia in the nasoturbinates and larynx of exposed groups. This response was judged to be indicative of upper respiratory tract tissue irritation. No significant differences in tumor incidence between control and hexane-exposed rats were found. In mice, uterine tissue from the high-exposure females exhibited a significant decrease in the severity of cystic endometrial hyperplasia compared to controls. An increase in the combined incidence of hepatocellular adenomas and carcinomas was observed in high-exposure female mice. The incidence of liver tumors was not increased in the mid- or low-exposure female mice or in male mice exposed to hexane. An increased incidence of pituitary adenomas was observed in female, but not male mice. This finding was not believed to have been treatment-related because the incidence in the control group was unusually low, and the incidence in exposed groups was not dose-related and was within the historical control range. No other neoplastic changes judged to be treatment-related were observed in tissues from male or female mice. In conclusion, chronic exposure to commercial hexane solvent at concentrations up to 9000 ppm was not carcinogenic to F-344 rats or to male B6C3F1 mice, but did result in an increased incidence of liver tumors in female mice. (+info)Oxidative stress in cells infected with bovine viral diarrhoea virus: a crucial step in the induction of apoptosis. (4/191)
Bovine viral diarrhoea virus (BVDV) belongs to the genus Pestivirus of the family Flaviviridae. Both a noncytopathic (ncp) and an antigenically related cytopathic (cp) BVDV can be isolated from persistently infected animals suffering from mucosal disease. In every case studied so far, the genomic changes leading to the cp biotype correlate with the production of the NS3 nonstructural protein, which, in the ncp biotype, is present in its uncleaved form, NS23. This report shows that, in contrast to ncp BVDV, the cp biotype induces apoptosis in cultured embryonic bovine turbinate cells. Early in the process of apoptosis, cells show a rise in the intracellular level of reactive oxygen species, which is indicative of oxidative stress. This precedes two hallmarks of apoptosis, caspase activation as shown by cleavage of the caspase substrate poly(ADP-ribose) polymerase, and DNA fragmentation. Cells were protected from apoptosis only by certain antioxidants (butylated hydroxyanisole and ebselen), whereas others (N-acetylcysteine, pyrrolidine dithiocarbamate, lipoic acid, dihydrolipoic acid and tiron) turned out to be ineffective. Antioxidants that protected cells from apoptosis prevented oxidative stress but failed to block virus growth. These observations suggest that oxidative stress, which occurs early in the interaction between cp BVDV and its host cell, may be a crucial event in the sequence leading to apoptotic cell death. Hence, apoptosis is not required for the multiplication of the cp biotype of BVDV. (+info)Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. (5/191)
How eosinophils are preferentially recruited to inflammatory sites remains elusive, but increasing evidence suggests that chemokines that bind to the CCR3 participate in this process. In this study, we investigated the transcript levels and chemotactic activity of CCR3-binding chemokines in nasal polyps, a disorder often showing prominent eosinophilia. We found that mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 was significantly increased in nasal polyps compared with turbinate mucosa from the same patients, or histologically normal nasal mucosa from control subjects. Interestingly, the novel CCR3-specific chemokine, eotaxin-2, showed the highest transcript levels. Consistent with these mRNA data, polyp tissue fluid exhibited strong chemotactic activity for eosinophils that was significantly inhibited by a blocking Ab against CCR3. When patients were treated systemically with glucocorticosteroids, the mRNA levels in the polyps were reduced to that found in turbinate mucosa for all chemokines. Together, these findings suggested an important role for CCR3-binding chemokines in eosinophil recruitment to nasal polyps. Such chemokines, therefore, most likely contribute significantly in the pathogenesis of eosinophil-related disorders; and the reduced chemokine expression observed after steroid treatment might reflect, at least in part, how steroids inhibit tissue accumulation of eosinophils. (+info)Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats. (6/191)
Rats repeatedly exposed to high ambient concentrations of ozone develop mucous cell metaplasia (MCM) in the nasal transitional epithelium (NTE). The present study was designed to determine the temporal relationships of ozone-induced inflammatory and epithelial responses and their correlation with subsequent MCM in the NTE of rats. Male F344/N rats were exposed to 0.5 ppm ozone, 8 h/day for 1, 2, or 3 days. Two h prior to sacrifice, all the rats were injected intraperitoneally with 5'-bromo-2-deoxyuridine (BrdU) to label epithelial cells undergoing DNA synthesis. Rats exposed to ozone for 1 or 2 days were killed 2 h after the exposure. Rats exposed to ozone for 3 days were killed 2 h or 1, 2, or 4 days after the exposure. Control rats were killed after a 7-day exposure to filtered air. One nasal passage from the anterior nasal cavity of each rat was fixed and processed for light microscopy to morphometrically determine the numeric densities of epithelial cells, neutrophils, and mucous cells, and the amount of intraepithelial mucosubstances in the NTE. The maxilloturbinate from the other nasal passage was processed for analysis of an airway mucin-specific gene (i.e., rMuc-5AC mRNA). Acute ozone exposure induced a rapid increase in rMuc-5AC mRNA levels prior to the onset of MCM, and the increased levels of rMuc-5AC mRNA persisted with MCM. Neutrophilic inflammation coincided with epithelial DNA synthesis and upregulation of rMuc-5AC, but was resolved when MCM first appeared in the NTE. The results of the present study suggest that upregulation of mucin mRNA by acute ozone exposure may be associated with the concurrent neutrophilic inflammation and epithelial hyperplasia in the NTE. Ozone-induced MCM may be dependent on these important pre-metaplastic responses (i.e., mucin mRNA upregulation, neutrophilic inflammation, and epithelial proliferation). (+info)Polyglutamylation and polyglycylation of alpha- and beta-tubulins during in vitro ciliated cell differentiation of human respiratory epithelial cells. (7/191)
Tubulins are the major proteins within centriolar and axonemal structures. In all cell types studied so far, numerous alpha- and beta-tubulin isoforms are generated both by expression of a multigenic family and various post-translational modifications. We have developed a primary culture of human nasal epithelial cells where the ciliated cell differentiation process has been observed and quantified. We have used this system to study several properties concerning polyglutamylation and polyglycylation of tubulin. GT335, a monoclonal antibody directed against glutamylated tubulins, stained the centriole/basal bodies and the axonemes of ciliated cells, and the centrioles of non-ciliated cells. By contrast, axonemal but not centriolar tubulins were polyglycylated. Several polyglutamylated and polyglycylated tubulin isotypes were detected by two-dimensional electrophoresis, using GT335 and a specific monoclonal antibody (TAP952) directed against short polyglycyl chains. Immunoelectron microscopy experiments revealed that polyglycylation only affected axonemal tubulin. Using the same technical approach, polyglutamylation was shown to be an early event in the centriole assembly process, as gold particles were detected in fibrogranular material corresponding to the first cytoplasmic structures involved in centriologenesis. In a functional assay, GT335 and TAP952 had a dose-dependent inhibitory effect on ciliary beat frequency. TAP952 had only a weak effect while GT335 treatment led to a total arrest of beating. These results strongly suggest that in human ciliated epithelial cells, tubulin polyglycylation has only a structural role in cilia axonemes, while polyglutamylation may have a function both in centriole assembly and in cilia activity. (+info)Analysis of ciliary beat pattern and beat frequency using digital high speed imaging: comparison with the photomultiplier and photodiode methods. (8/191)
BACKGROUND: The aim of this study was to determine the relationship of the power and recovery stroke of respiratory cilia using digital high speed video imaging. Beat frequency measurements made using digital high speed video were also compared with those obtained using the photomultiplier and modified photodiode techniques. METHOD: Ciliated epithelium was obtained by brushing the inferior nasal turbinate of 20 healthy subjects. Ciliated edges were observed by microscopy and the deviation of cilia during their recovery stroke relative to the path travelled during their power stroke was measured. Beat frequency measurements made by digital high speed video analysis were compared with those obtained using the photomultiplier and modified photodiode. RESULTS: Cilia were found to beat with a forward power stroke and a backward recovery stroke within the same plane. The mean angular deviation of the cilia during the recovery stroke from the plane of the forward power stroke was only 3.6 degrees (95% CI 3.1 to 4.1). There was a significant difference in beat frequency measurement between the digital high speed video (13.2 Hz (95% CI 11.8 to 14.6)) and both photomultiplier (12.0 Hz (95% CI 10.8 to 13.1), p = 0.01) and photodiode (11.2 Hz (95% CI 9.9 to 12.5), p<0.001) techniques. The Bland-Altman limits of agreement for the digital high speed video were -2.75 to 5.15 Hz with the photomultiplier and -2.30 to 6.06 Hz with the photodiode. CONCLUSION: Respiratory cilia beat forwards and backwards within the same plane without a classical sideways recovery sweep. Digital high speed video imaging allows both ciliary beat frequency and beat pattern to be evaluated. (+info)The term "atrophic" refers to the wasting away or degeneration of tissue, which is a hallmark feature of this condition. The atrophy of the nasal mucosa can lead to a decrease in the production of mucus, which can impair the body's ability to fight off infections and allergens.
Rhinitis, atrophic can be caused by a variety of factors, including allergies, viral infections, and exposure to environmental irritants such as smoke or pollution. The condition is more common in older adults and can be associated with other medical conditions such as asthma, sinusitis, and chronic bronchitis.
There are several risk factors for developing rhinitis, atrophic, including:
1. Allergies: People with allergies are more likely to develop rhinitis, atrophic.
2. Age: The condition is more common in older adults.
3. Family history: A family history of allergies or respiratory conditions can increase the risk of developing rhinitis, atrophic.
4. Exposure to environmental irritants: Smoke, pollution, and other environmental irritants can increase the risk of developing the condition.
5. Previous respiratory infections: People who have had previous respiratory infections, such as the common cold or flu, may be more likely to develop rhinitis, atrophic.
There are several symptoms of rhinitis, atrophic, including:
1. Nasal congestion: The nasal passages can become inflamed and congested, making it difficult to breathe through the nose.
2. Rhinorrhea: Thick, yellowish discharge from the nose is a common symptom of rhinitis, atrophic.
3. Postnasal drip: This can cause a sore throat and coughing.
4. Loss of smell: The inflammation in the nasal passages can damage the olfactory nerve, leading to a loss of sense of smell.
5. Sinus pressure: The condition can lead to sinus pressure and pain.
There are several complications of rhinitis, atrophic, including:
1. Chronic sinusitis: The condition can lead to chronic sinusitis, which can cause pain, facial swelling, and difficulty breathing through the nose.
2. Asthma: Some people with rhinitis, atrophic may develop asthma.
3. Middle ear infections: The infection in the nasal passages can spread to the middle ear, leading to ear infections.
4. Meningitis: In rare cases, the infection can spread to the meninges, leading to meningitis.
There are several treatments for rhinitis, atrophic, including:
1. Nasal decongestants: These medications can help reduce swelling in the nasal passages and relieve congestion.
2. Antihistamines: These medications can help reduce nasal discharge and relieve itching.
3. Corticosteroids: These medications can help reduce inflammation in the nasal passages.
4. Antibiotics: If there is a bacterial infection, antibiotics may be prescribed.
5. Saline nasal sprays: These can help moisturize the nasal passages and thin mucus.
6. Humidifiers: Using a humidifier can help keep the nasal passages moist and relieve congestion.
7. Nasal strips: These can help open up the nasal passages and improve breathing.
8. Surgery: In severe cases, surgery may be necessary to remove polyps or correct anatomical abnormalities.
It is important to note that these treatments may not completely cure the condition, but they can help manage the symptoms and prevent complications. It is also important to work with a healthcare professional to determine the best course of treatment for your specific case.
* Nasal polyps: Growths in the nasal passages that can block airflow.
* Deviated septum: A crooked partition between the two sides of the nasal passages that can narrow or block one side.
* Enlarged adenoids or turbinate bones: These structures can grow and obstruct the airway.
* Trauma to the nose: A broken nose or other injury can cause obstruction of the nasal passages.
* Infections such as rhinitis, sinusitis, or allergies: Swelling and congestion in the nasal passages can cause obstruction.
* Nasal tumors: Growths in the nasal passages that can block airflow.
* Anatomical abnormalities: Some people may be born with abnormalities such as a narrow nasal passage or a deviated septum, which can cause nasal obstruction.
Symptoms of Nasal Obstruction include:
* Difficulty breathing through the nose
* Congestion or stuffiness in the nose
* Noise or snoring while breathing
* Sleep disturbances due to difficulty breathing
* Headaches or facial pain due to straining to breathe
* Postnasal drip (a sensation of mucus running down the back of the throat)
* Coughing or sneezing
Treatment for Nasal Obstruction depends on the underlying cause and can include:
* Medications such as nasal decongestants, antihistamines, and steroids to reduce swelling and congestion.
* Nasal strips or dilators to open up the nasal passages.
* Saline nasal irrigation to flush out mucus and debris.
* Surgery to remove nasal polyps, correct a deviated septum, or other structural abnormalities.
* Allergy treatment to reduce inflammation and congestion.
It is important to seek medical attention if you experience persistent or severe symptoms of nasal obstruction as it can lead to complications such as sinus infections, sleep disorders, and other health problems. A healthcare professional can diagnose the underlying cause and recommend appropriate treatment options.
Some common examples of nose diseases include:
1. Nasal congestion: This is a condition where the nasal passages become blocked or constricted, leading to difficulty breathing through the nose. It can be caused by a variety of factors, such as allergies, colds, or sinus infections.
2. Sinusitis: This is an inflammation of the sinuses, which are air-filled cavities within the skull. Sinusitis can cause headaches, facial pain, and difficulty breathing through the nose.
3. Nasal polyps: These are growths that occur in the nasal passages and can block the flow of air through the nose. They can be caused by allergies or other conditions.
4. Rhinitis: This is an inflammation of the nasal passages, which can cause symptoms such as congestion, runny nose, and sneezing. There are several different types of rhinitis, including allergic rhinitis and non-allergic rhinitis.
5. Nasal tumors: These are abnormal growths that occur in the nasal passages and can cause symptoms such as nasal congestion, bleeding, and facial pain. They can be benign or malignant.
6. Deviated septum: This is a condition where the thin wall of cartilage and bone that separates the two sides of the nasal passages is displaced, causing difficulty breathing through the nose.
7. Nasal dryness: This can be caused by a variety of factors, such as dry air, allergies, or certain medications. It can lead to symptoms such as nasal congestion and difficulty breathing through the nose.
8. Nasal fractures: These are breaks in the bones of the nose, which can be caused by trauma such as a blow to the face. They can cause symptoms such as pain, swelling, and difficulty breathing through the nose.
9. Sinusitis: This is an inflammation of the sinuses, which are air-filled cavities in the skull. It can cause symptoms such as facial pain, headaches, and congestion.
10. Nasal polyps: These are growths that occur in the nasal passages and can cause symptoms such as nasal congestion, loss of sense of smell, and facial pain. They can be caused by a variety of factors, including allergies and chronic sinusitis.
These are just a few examples of the many different conditions that can affect the nose. If you are experiencing symptoms such as nasal congestion, loss of sense of smell, or facial pain, it is important to see a healthcare professional for proper diagnosis and treatment.
Pasteurella infections are more common in people who work closely with animals, such as veterinarians, farm workers, and pet owners. The bacteria can enter the body through open wounds, cuts, or abrasions, and it can cause a variety of illnesses, including:
1. Pasteurellosis: A respiratory infection caused by Pasteurella multocida, which is common in dogs and cats. It can be transmitted to humans through close contact with infected animals.
2. Pneumonia: A type of lung infection that can be caused by Pasteurella multocida, especially in people with weakened immune systems or pre-existing respiratory conditions.
3. Sinusitis: An infection of the sinuses, which are air-filled cavities in the skull, can be caused by Pasteurella multocida.
4. Cellulitis: A bacterial infection of the skin and underlying tissue that can be caused by Pasteurella multocida.
5. Endocarditis: An infection of the inner lining of the heart, which is rare but can be caused by Pasteurella multocida.
The symptoms of Pasteurella infections can vary depending on the type of infection and the severity of the illness. Common symptoms include fever, cough, difficulty breathing, chills, headache, and fatigue. In severe cases, Pasteurella infections can lead to life-threatening complications such as sepsis or meningitis.
Diagnosis of Pasteurella infections typically involves a combination of physical examination, medical history, and laboratory tests, including blood cultures, chest X-rays, and CT scans. Treatment usually involves antibiotics to eradicate the bacteria, as well as supportive care to manage symptoms and prevent complications.
Prevention of Pasteurella infections primarily involves avoiding contact with animals that may carry the bacteria, as well as good hygiene practices such as handwashing and covering wounds. In some cases, antibiotics may be prescribed to prevent infection in high-risk individuals, such as those with weakened immune systems or pre-existing respiratory conditions.
Overall, while Pasteurella infections are rare, they can be serious and potentially life-threatening. It is important to seek medical attention promptly if symptoms persist or worsen over time, especially in high-risk individuals.
Nasal polyps are typically treated with medications such as nasal sprays or oral steroids, which can help reduce inflammation and shrink the size of the polyps. In some cases, surgery may be necessary to remove the polyps or repair any structural damage they have caused.
Here are some key points to note about nasal polyps:
1. They are usually benign: Nasal polyps are not cancerous, and they do not spread to other parts of the body.
2. They can be caused by allergies: Allergic reactions can lead to inflammation in the nasal passages, which can cause polyps to grow.
3. They can be treated with medications: Nasal sprays and oral steroids are commonly used to treat nasal polyps.
4. They can obstruct breathing: Large polyps can block the flow of air through the nasal passages, leading to breathing difficulties.
5. They can cause loss of sense of smell: Polyps can damage the olfactory nerve, which is responsible for our sense of smell.
6. They can be associated with other conditions: Nasal polyps can be a symptom of other conditions such as cystic fibrosis or primary immunodeficiency disorders.
Symptoms of Bordetella Infections typically include a severe cough, fever, and difficulty breathing. In severe cases, the infection can lead to pneumonia or other complications that may require hospitalization.
Diagnosis of Bordetella Infections is usually made through laboratory tests, such as a PCR (polymerase chain reaction) test or a culture. Treatment typically involves antibiotics, which can help reduce the severity and duration of symptoms. Prevention is key, as there is no specific treatment for Bordetella Infections once they have developed. Vaccination against Bordetella pertussis is recommended for children and adults to protect against infection.
There are several types of rhinitis, including:
1. Allergic rhinitis: This type of rhinitis is caused by an allergic reaction to substances such as pollen, dust mites, or pet dander. Symptoms include sneezing, congestion, runny nose, and itchy eyes.
2. Viral rhinitis: This type of rhinitis is caused by a viral infection and can be accompanied by symptoms such as fever, headache, and fatigue.
3. Bacterial rhinitis: This type of rhinitis is caused by a bacterial infection and can be treated with antibiotics. Symptoms include thick yellow or green discharge from the nose and facial pain.
4. Non-allergic rhinitis: This type of rhinitis is not caused by an allergic reaction and can be triggered by factors such as hormonal changes, medications, or environmental irritants. Symptoms include postnasal drip and nasal congestion.
Rhinitis can be diagnosed through a physical examination of the nose and sinuses, as well as through tests such as a nasal endoscopy or imaging studies. Treatment for rhinitis depends on the underlying cause and may include medications such as antihistamines, decongestants, or antibiotics, as well as lifestyle changes such as avoiding allergens or using saline nasal sprays. In severe cases, surgery may be necessary to correct physical abnormalities in the nose and sinuses.
Rhinitis Vasomotor is often associated with allergies, and it can be triggered by a variety of factors, including pollen, dust mites, mold, and pet dander. Treatment options for rhinitis vasomotor include antihistamine medications, decongestants, nasal sprays, and immunotherapy.
The term "rhinitis" refers to inflammation of the nose and sinuses, and it can be caused by a variety of factors, including infections, allergies, and irritants. Vasomotor rhinitis is one type of rhinitis that is specifically associated with the autonomic nervous system and the regulation of blood flow to the nasal passages.
A disease that affects pigs, including viral, bacterial, and parasitic infections, as well as genetic disorders and nutritional deficiencies. Some common swine diseases include:
1. Porcine Reproductive and Respiratory Syndrome (PRRS): A highly contagious viral disease that can cause reproductive failure, respiratory problems, and death.
2. Swine Influenza: A viral infection similar to human influenza, which can cause fever, coughing, and pneumonia in pigs.
3. Erysipelas: A bacterial infection that causes high fever, loss of appetite, and skin lesions in pigs.
4. Actinobacillosis: A bacterial infection that can cause pneumonia, arthritis, and abscesses in pigs.
5. Parasitic infections: Such as gastrointestinal parasites like roundworms and tapeworms, which can cause diarrhea, anemia, and weight loss in pigs.
6. Scrapie: A degenerative neurological disorder that affects pigs and other animals, causing confusion, aggression, and eventually death.
7. Nutritional deficiencies: Such as a lack of vitamin E or selenium, which can cause a range of health problems in pigs, including muscular dystrophy and anemia.
8. Genetic disorders: Such as achondroplasia, a condition that causes dwarfism and deformities in pigs.
9. Environmental diseases: Such as heat stress, which can cause a range of health problems in pigs, including respiratory distress and death.
It's important to note that many swine diseases have similar symptoms, making accurate diagnosis by a veterinarian essential for effective treatment and control.
Nose neoplasms refer to any type of abnormal growth or tumor that develops in the nose or nasal passages. These tumors can be benign (non-cancerous) or malignant (cancerous), and they can affect people of all ages.
Types of Nose Neoplasms[2]
There are several types of nose neoplasms, including:
1. Nasal polyps: These are benign growths that can occur in the nasal passages and are usually associated with allergies or chronic sinus infections.
2. Nasal carcinoma: This is a type of cancer that affects the nasal passages and can be either benign or malignant.
3. Esthesioneuroblastoma: This is a rare type of cancer that occurs in the nasal passages and is usually found in children.
4. Adenocarcinoma: This is a type of cancer that affects the glandular tissue in the nose and can be either benign or malignant.
5. Squamous cell carcinoma: This is a type of cancer that affects the squamous cells in the skin and mucous membranes of the nose.
Symptoms of Nose Neoplasms[3]
The symptoms of nose neoplasms can vary depending on the type and location of the tumor. Some common symptoms include:
1. Nasal congestion or blockage
2. Nasal discharge or bleeding
3. Loss of sense of smell or taste
4. Headaches
5. Sinus infections or other respiratory problems
6. Swelling or lumps in the nose or face
7. Difficulty breathing through the nose
Diagnosis and Treatment of Nose Neoplasms[4]
The diagnosis of nose neoplasms typically involves a combination of physical examination, imaging tests (such as CT scans or MRI), and biopsies. Treatment depends on the type and location of the tumor, and may involve surgery, radiation therapy, chemotherapy, or a combination of these. Some common treatment options include:
1. Surgical excision: This involves removing the tumor and any affected tissue through a surgical procedure.
2. Radiation therapy: This involves using high-energy beams to kill cancer cells.
3. Chemotherapy: This involves using drugs to kill cancer cells.
4. Laser therapy: This involves using a laser to remove or destroy the tumor.
5. Cryotherapy: This involves using extreme cold to destroy the tumor.
Prognosis and Follow-Up Care[5]
The prognosis for nose neoplasms depends on the type and location of the tumor, as well as the stage of the cancer. In general, early detection and treatment improve the chances of a successful outcome. Follow-up care is important to monitor the patient's condition and detect any recurrences or complications. Some common follow-up procedures include:
1. Regular check-ups with an otolaryngologist (ENT specialist)
2. Imaging tests (such as CT scans or MRI) to monitor the tumor and detect any recurrences
3. Biopsies to evaluate any changes in the tumor
4. Treatment of any complications that may arise, such as bleeding or infection.
Lifestyle Changes and Home Remedies[6]
There are several lifestyle changes and home remedies that can help improve the symptoms and quality of life for patients with nose neoplasms. These include:
1. Maintaining good hygiene, such as regularly washing the hands and avoiding close contact with others.
2. Avoiding smoking and other tobacco products, which can exacerbate the symptoms of nose cancer.
3. Using saline nasal sprays or drops to keep the nasal passages moist and reduce congestion.
4. Applying warm compresses to the affected area to help reduce swelling and ease pain.
5. Using over-the-counter pain medications, such as acetaminophen or ibuprofen, to manage symptoms.
6. Avoiding blowing the nose, which can dislodge the tumor and cause bleeding.
7. Avoiding exposure to pollutants and allergens that can irritate the nasal passages.
8. Using a humidifier to add moisture to the air and relieve dryness and congestion in the nasal passages.
9. Practicing good sleep hygiene, such as avoiding caffeine and electronic screens before bedtime and creating a relaxing sleep environment.
10. Managing stress through relaxation techniques, such as meditation or deep breathing exercises.
Nose neoplasms can have a significant impact on a person's quality of life, but with proper diagnosis and treatment, many patients can experience improved symptoms and outcomes. It is important for patients to work closely with their healthcare providers to develop a personalized treatment plan that addresses their specific needs and goals. Additionally, lifestyle changes and home remedies can help improve symptoms and quality of life for patients with nose neoplasms.
Some common types of acquired nose deformities include:
1. Nasal septal perforation: a hole or tear in the thin wall of cartilage and bone that separates the two sides of the nasal passages. This can be caused by injury, infection, or certain medical conditions.
2. Nasal polyps: growths on the lining of the nose that can block the nasal passages and affect breathing. They are often associated with allergies or asthma.
3. Enlarged turbinate bones: the turbinate bones inside the nose can become enlarged due to allergies, infection, or other factors, leading to blockage of the nasal passages and difficulty breathing.
4. Nasal trauma: injury to the nose, such as a blow to the face or a fall, can cause deformities such as a deviated septum or broken noses.
5. Skin cancer: can occur on the nose and cause deformities if left untreated.
6. Cysts and tumors: benign or malignant growths that can develop in the nose and cause deformities.
7. Nasal fractures: breaks in the bones of the nose, which can cause deformities if not properly treated.
8. Rhinophyma: a condition characterized by enlarged oil glands in the nose, leading to redness, swelling, and deformity. It is often associated with rosacea.
9. Nasal septal pterygium: a growth of tissue on the nasal septum that can cause blockage of the nasal passages and affect breathing.
10. Nasal dermoids: benign growths that occur in the skin and mucous membranes of the nose, which can cause deformities if left untreated.
Perennial allergic rhinitis can be caused by a variety of allergens, including:
1. Dust mites: These tiny organisms live in bedding, carpets, and upholstered furniture and feed on human skin cells. Their waste products are the primary allergen that triggers an allergic reaction.
2. Mold: This type of fungus grows in damp environments and can be found in basements, bathrooms, and outdoors.
3. Pet dander: The dead skin flakes from animals such as cats, dogs, and birds can trigger an allergic reaction in some people.
4. Insect bites: Some people may experience an allergic reaction to the saliva or venom of certain insects such as bees, wasps, or hornets.
5. Food: Certain foods such as milk, eggs, wheat, and nuts can cause an allergic reaction in some people.
The symptoms of perennial allergic rhinitis are similar to those of seasonal allergic rhinitis, but they occur throughout the year rather than just during a specific season. Treatment options for perennial allergic rhinitis include over-the-counter or prescription medications such as antihistamines, decongestants, and corticosteroids, as well as immunotherapy, which involves exposing the body to small amounts of the allergen over time to build up tolerance.
* Nasal congestion and discharge
* Headaches
* Pain and pressure in the face, particularly in the cheeks and forehead
* Fatigue and fever
* Loss of smell or taste
There are several types of sinusitis, including:
* Acute sinusitis: This type of sinusitis is caused by a sudden infection and typically lasts for less than four weeks.
* Chronic sinusitis: This type of sinusitis is caused by a long-term infection or inflammation that persists for more than 12 weeks.
* Recurrent sinusitis: This type of sinusitis occurs when acute sinusitis keeps coming back, often due to repeat infections or allergies.
* Allergic fungal sinusitis: This type of sinusitis is caused by an allergic reaction to fungus that grows in the sinuses.
* Chronic rhinosinusitis: This type of sinusitis is characterized by chronic inflammation and nasal congestion, often due to an allergic response.
Treatment for sinusitis depends on the underlying cause and may include antibiotics, antihistamines, decongestants, nasal saline irrigations, or surgery. It is important to seek medical attention if symptoms persist or worsen over time, as untreated sinusitis can lead to complications such as meningitis or brain abscess.
Glossary of gastropod terms
Stenothyridae
Choristodera
Champsosaurus
Nonallergic rhinitis
Evolution of mammals
Saichania
Margarella pruinosa
Nocturnal bottleneck
Nasal cavity
Leptocollonia thielei
Gibbula hisseyiana
Cinnamomum mercadoi
Sukashitrochus morleti
Aesculus turbinata
Liotina crenata
Calliostoma turbinum
Monilea chiliarches
Eulithidium rubrilineatum
Pyrgocythara scammoni
Giovanni Domenico Santorini
Liotia
Bolma
Glanosuchus
Nasal concha
Minolops cinerea
Cirsonella densilirata
Cantrainea sunderlandi
Chonospeira
Vaceuchelus semilugubris
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Turbinate Reduction
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Hypertrophy4
- https://youtu.be/N-7DjsK6Y3M Here in this article lets understand What are Turbinates in the nose, Enlarged turbinates surgery, Causes of turbinate hypertrophy, What are the symptoms of Enlarged turbinates? (sinusdoctor.com)
- Most swelling of the turbinates is brief, but over time the turbinate bone and tissue can become permanently enlarged, a condition called turbinate hypertrophy. (juliezweigmd.com)
- Women who use oral contraceptives or undergo hormone replacement therapy are at higher risk for turbinate hypertrophy due to hormone levels. (juliezweigmd.com)
- When the turbinate increases in size, then it is known as inferior turbinate hypertrophy. (medpersia.com)
Inferior turbinates7
- Surgical reduction of the turbinates (submucous resection inferior turbinates) is a commonly performed nasal procedure by itself or with a septoplasty or sinus surgery . (nwentsurgerycenter.com)
- Inferior turbinates that swell to the point where they cause a nasal obstruction are known as hyperplastic turbinates. (inspire-med.com)
- The leptin / leptin receptor expression has been investigated in a study with 40 biopsies from allergic (AR, nâ ¯=â ¯18) and non-allergic (C, nâ ¯=â ¯22) inferior turbinates , using immunohistochemistry , immunofluorescence staining and RT-PCR. (bvsalud.org)
- In addition, extracts from in vitro samples prepared from primary cells of inferior turbinates as well as in vitro cultured human nasal epithelial RPMI 2650 cells (ATCC-CCL-30) were also tested for leptin expression and activation of the Notch-1 pathway. (bvsalud.org)
- The inferior turbinates are the largest and the most important turbinates, while middle turbinates are the second-largest turbinates. (medpersia.com)
- The inferior turbinates, which are the lowest conchae in your nose. (healthline.com)
- 1. Variant anatomy of nasal turbinates: supreme, superior and middle conchae bullosae, paradoxical superior and inferior turbinates, and middle accessory turbinate. (nih.gov)
Nose13
- A tool is placed in the nose to change the position of the turbinate. (medlineplus.gov)
- Figure Legend: Figure 1 Nose, Turbinate - Normal in a male B6C3F1/N mouse from a subchronic study. (nih.gov)
- Figure 4 Nose, Turbinate - Atrophy in a male B6C3F1/N mouse from a chronic study. (nih.gov)
- The turbinates are finger-like membrane projections located along each side of the nose. (nwentsurgerycenter.com)
- Within the nose are the turbinate bones and tissue that play a significant role in nasal and overall health. (juliezweigmd.com)
- Turbinates are located on the outside of the nasal passages on both sides of the nose, providing warmth and moisture to the air as it enters the nose. (juliezweigmd.com)
- What are Turbinates in the Nose? (medpersia.com)
- The major three functions of these turbinates are- they filter the air passing through the nose reaching to the lungs, humidify and warms up the air. (medpersia.com)
- The swellings within the nose that are responsible for humidification and warming of the air breathe in through the nose are known as nasal turbinates. (medpersia.com)
- A radiofrequency turbinate reduction is used to treat turbinates that suffer from chronic enlargement, and may also accompany a septoplasty depending on the condition of the nose at that time. (texasent.net)
- A functional and aesthetic solution for saddle nose deformity: the use of the inferior turbinate bone. (bezmialem.edu.tr)
- Concha bullosa happens when one of the conchae, or turbinates, inside your nose becomes filled with a pocket of air. (healthline.com)
- The superior turbinates, which are the highest conchae in your nose, near your brain. (healthline.com)
Radiofrequency6
- Laser light or radiofrequency energy goes through this tube and shrinks the turbinate tissue. (medlineplus.gov)
- Allergic Rhinitis: Does Initial Radiofrequency Turbinate Reduction Affect Outcomes? (pulmonologyadvisor.com)
- Can the use of radiofrequency turbinate reduction prior to drug therapy for allergic rhinitis improve patients' clinical response to treatment? (pulmonologyadvisor.com)
- Using radiofrequency turbinate reduction (RFTR) prior to drug therapy for moderate to severe allergic rhinitis hastens initial clinical improvement but does not alter the disease course. (pulmonologyadvisor.com)
- Partial shrinkage of turbinate can be performed with radiofrequency technology. (ent.com.hk)
- During the radiofrequency turbinate reduction, your ENT will use a needle-like device to cauterize the turbinates and reduce their size. (texasent.net)
Swab2
Allergies6
- Allergies or other nasal problems can cause the turbinates to swell and block airflow. (medlineplus.gov)
- It came to my attention less than a year ago that my 12 year old daughter had been suffering from a severe deviated septum as well as over-sized turbinates due to terrible allergies. (todaysface.com)
- Enlarged turbinates caused by allergies, infections, or a deviated septum are often responsible for nasal airway obstruction. (nwentsurgerycenter.com)
- Colds, allergies and other conditions can cause inflammation of the turbinates, resulting in nasal congestion. (juliezweigmd.com)
- It is normal for turbinates to become inflamed when you have a cold, seasonal allergies or sinus issue. (juliezweigmd.com)
- The lower part is filled by inferior turbinate of the nasal airway and can result in swelling due to infections or allergies. (medpersia.com)
Septoplasty3
- Septoplasty and turbinate surgery. (medlineplus.gov)
- He also did a septoplasty and turbinate reduction to improve my breathing. (todaysface.com)
- My daughter had the surgery in January 2014 which included septoplasty and turbinate reduction. (todaysface.com)
Swell2
- Why do Turbinates swell? (sinusdoctor.com)
- Turbinates abnormality can lead to variations in their positions and size that makes it difficult to know till what size they will swell. (medpersia.com)
Resection2
- Turbinate Resection. (inspire-med.com)
- Submucous resection aims to preserve the mucosa of the turbinate in order to reduce side effects. (inspire-med.com)
Epithelial2
- The pathogenesis of turbinate atrophy has not been elucidated, but it has been hypothesized that cytokines released by epithelial cells and/or inflammatory cells during chronic inflammation shift the balance between bone resorption and new bone production toward osteoclastic activity (and perhaps decreased osteoblastic activity, as well), resulting in a net loss of bone. (nih.gov)
- In vitro , in primary turbinate epithelial cells , the expression of leptin receptor and Notch-1 significantly decreased in AR as compared to C. Moreover, in RPMI 2650 cells , leptin receptor expression was shown to be induced by Notch-1 ligand signaling. (bvsalud.org)
General anesthesia1
- In rare occurrences, parts of the turbinate may actually be removed through a more traditional surgical procedure that requires general anesthesia and a much longer recovery period. (texasent.net)
Surgery7
- Otto BA, Barnes C. Surgery of the turbinate. (medlineplus.gov)
- 2 anatomies were then created by virtual surgery, mimicking EMM and M-EMM, with the latter sparing the anterior portion of inferior turbinate and medial maxillary sinus wall. (physiciansweekly.com)
- Call (678) 483-8833 to learn more turbinate surgery at Northwest ENT Surgery Center. (nwentsurgerycenter.com)
- hyperplastic turbinates often require surgery. (inspire-med.com)
- This procedure is similar to laser surgery, but relies on the application of extreme cold to destroy the turbinate through freezing. (inspire-med.com)
- Who should consider Turbinate Surgery? (medpersia.com)
- The surgery reduces the swelling of the turbinate. (medpersia.com)
Widening the nasal airway1
- Either total or partial, this procedure involves removing all or part of the inferior turbinate while widening the nasal airway. (inspire-med.com)
Lesions2
- It may be accompanied by other bone lesions, such as hyperostosis (increased bone), necrosis of the turbinate bone, or perforation of the nasal septum. (nih.gov)
- Lasers focus a beam of light on the inferior turbinate to create lesions that allow for removal. (inspire-med.com)
Procedure3
- The surgical procedure is performed to shrink the turbinates to ease the severe condition of nasal obstruction and nasal congestion. (medpersia.com)
- The surgical procedure is performed by inserting an endoscope to have better visual access to the turbinates. (medpersia.com)
- The recovery from this type of turbinate reduction procedure is very minimal, with all scar tissue generally being healed within three weeks. (texasent.net)
Bone6
- Part XII: Atrophy of Bone in Nasal Turbinates. (nih.gov)
- These turbinates are made up of thin bone and is covered with nasal membranes. (medpersia.com)
- By using special instruments, the removal of turbinate bone can be done by making a small incision. (medpersia.com)
- On the other hand, the turbinate bone can be trampeled for not allowing the turbinate to stick to far in the nasal sidewalls. (medpersia.com)
- With the help of heat or turbinate excision, the bone cover can be reduced. (medpersia.com)
- The lateral walls contain spiral-shaped mucosal folds overlying concha-shaped bone called turbinates and various sinus-drainage ostia. (medscape.com)
Mucosal1
- 1. The PLA303 electrode uses minimally invasive ablation technology to gently dissolve submucosal tissue at the molecular level while preserving the mucosal surface during turbinate reduction procedures. (plasmasurgerysystem.com)
Symptoms1
- If you have symptoms of turbinate dysfunction, it is important to seek diagnosis and treatment for better health. (juliezweigmd.com)
Airway1
- A number of surgical procedures are effective in reducing the size of the inferior turbinate, clearing up the airway to eliminate any associated breathing or sinus problems. (inspire-med.com)
Allergic1
- Notch-1 decreased expression contributes to leptin receptor downregulation in nasal epithelium from allergic turbinates. (bvsalud.org)
Pneumatization2
- This is also known as pneumatization of the turbinate. (healthline.com)
- 19. Pneumatization of turbinates. (nih.gov)
Lungs1
- Turbinates are small nasal structures that help keep the air clean of contaminants before it passes into your lungs. (texasent.net)
Medial1
- The olfactory recesses are located at the superiormost portion of the nasal cavity, medial to the paired superior turbinates. (medscape.com)
Chronic1
- Chronic or long-term turbinate dysfunction occurs in about 50% of the population. (juliezweigmd.com)
Conchae2
- The middle turbinates, which sit between the superior and inferior conchae. (healthline.com)
- 8. 'Conchae bullosis': a rare case with bilateral triple turbinate pneumatisations. (nih.gov)
Projections1
- Turbinates, bony projections from the nasal cavity wall, increase the surface area within the nasal cavity lined by the OE. (nih.gov)
Pathology1
- 17. [The middle turbinate as the cause of sinusal pathology]. (nih.gov)
Lateral2
- There is an adhesion of this maxil ary turbinate to the lateral wall. (nih.gov)
- Notice the relationship between the septum, upper lateral cartilage, pyriform aperture, and inferior turbinate. (medscape.com)
Increases1
- The spiral or curved nature of the turbinates increases the surface area and contact with inspired air. (medscape.com)
Procedures1
- This can include turbinate reduction procedures that can effectively improve breathing, sleep and health. (juliezweigmd.com)
Respiratory2
- An adhesion is present between the two tips of a nasal turbinate, with associated squamous metaplasia of respiratory epithelium. (nih.gov)
- At Julie Zweig, MD Integrative Sleep & ENT, we provide treatment for turbinate dysfunction with integrative and functional medicine to improve respiratory and overall wellness. (juliezweigmd.com)
Diagnosis2
- and Diagnosis, Enlarged turbinates treatment. (sinusdoctor.com)
- At Julie Zweig, MD Integrative Sleep & ENT, we offer diagnosis and treatment for turbinate dysfunction at our Alpharetta, GA, clinic. (juliezweigmd.com)
Functional1
- Symptomatic women candidates are having anatomically or functional abnormal turbinates. (medpersia.com)
Regulate2
- We further show that FGF20 signals to the underlying mesenchyme to regulate the growth of turbinates. (nih.gov)
- The human body contains three pairs of turbinates - long, curled nasal bones that warm and humidify inhaled air and regulate breathing through the nasal passages. (inspire-med.com)
Variations1
- 6. Anatomical variations of nasal turbinates. (nih.gov)
Infections1
- The turbinates help in directing the flow of air and protects the body from irritants and infections of the inhaled air. (medpersia.com)
Middle5
- The turbinates are classified as inferior, middle and superior and all are divided by the septum. (inspire-med.com)
- The superior (upper), middle and inferior (lower) are the three types of turbinates. (medpersia.com)
- You may notice some pain or discomfort around your sinuses when the middle turbinates get filled with an air pocket. (healthline.com)
- 3. Vertical and sagittal combinations of concha bullosa media and paradoxical middle turbinate. (nih.gov)
- 11. Rare Anatomic Variation: Pneumatized Secondary Middle Turbinate. (nih.gov)
Walls1
- These turbinates are attached to both the left and right walls of the nasal cavity. (medpersia.com)
Size3
- The size of the turbinates is decreased compared with normal turbinates shown in Figure 1. (nih.gov)
- The size of these turbinates can increase, leading to nasal blockage caused by exposure to irritants. (medpersia.com)
- The aim is to reduce the size of the turbinate instead of removing the entire turbinate. (medpersia.com)
Superior1
- 12. Bifid and secondary superior nasal turbinates. (nih.gov)
Reduce2
- Prescription nasal sprays, antihistamines, and allergy testing and treatment may reduce nasal blockage caused by enlarged turbinates. (nwentsurgerycenter.com)
- The nasal sprays can be used to reduce the turbinate swelling. (medpersia.com)
Breathe1
- The turbinates are crucial in allowing us to breathe properly. (inspire-med.com)
Normal3
Surface area1
- These studies thus identify a population of OE progenitor cells that function to scale OE surface area with the underlying turbinates. (nih.gov)