A localized proliferation of plant tissue forming a swelling or outgrowth, commonly with a characteristic shape and unlike any organ of the normal plant. Plant tumors or galls usually form in response to the action of a pathogen or a pest. (Holliday, P., A Dictionary of Plant Pathology, 1989, p330)
A species of gram-negative, aerobic bacteria isolated from soil and the stems, leafs, and roots of plants. Some biotypes are pathogenic and cause the formation of PLANT TUMORS in a wide variety of higher plants. The species is a major research tool in biotechnology.
A genus of gram-negative, aerobic, rod-shaped bacteria that activate PLANT ROOT NODULATION in leguminous plants. Members of this genus are nitrogen-fixing and common soil inhabitants.
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
The functional hereditary units of PLANTS.
A cell line derived from cultured tumor cells.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
New immature growth of a plant including stem, leaves, tips of branches, and SEEDLINGS.
A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Deoxyribonucleic acid that makes up the genetic material of plants.
Processes orchestrated or driven by a plethora of genes, plant hormones, and inherent biological timing mechanisms facilitated by secondary molecules, which result in the systematic transformation of plants and plant parts, from one stage of maturity to another.
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Plants or plant parts which are harmful to man or other animals.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.
The stonecrop plant family of the order ROSALES, subclass Rosidae, class Magnoliopsida that grow in warm, dry regions. The leaves are thick. The flower clusters are red, yellow, or white.
The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.
A group of antibiotic aminoglycosides differing only in the number of repeating residues in the peptide side chain. They are produced by Streptomyces and Actinomyces and may have broad spectrum antimicrobial and some antiviral properties.
A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.
A genus of gram negative, aerobic, rod-shaped bacteria found in soil, plants, and marine mud.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Viruses parasitic on plants higher than bacteria.
The movement of one cell within another cell (non-phagocytic).
The processes by which one cell actively invades and becomes internalized within another cell.
Elements of limited time intervals, contributing to particular results or situations.
Cells in certain regions of an embryo that self-regulate embryonic development. These organizers have been found in dorsal and ventral poles of GASTRULA embryos, including Spemann organizer in amphibians, and Hensen node in chicken and mouse. These organizer cells communicate with each other via a network of secreted signaling proteins, such as BONE MORPHOGENETIC PROTEINS and their antagonists (chordin and noggin).
A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.
A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.
A family of smad proteins that undergo PHOSPHORYLATION by CELL SURFACE RECEPTORS in response to TRANSFORMING GROWTH FACTOR BETA; ACTIVIN; or BONE MORPHOGENETIC PROTEIN signaling.
An inhibitory smad protein that associates with TRANSFORMING GROWTH FACTOR BETA RECEPTORS and BONE MORPHOGENETIC PROTEIN RECEPTORS. It negatively regulates SIGNAL TRANSDUCTION PATHWAYS by inhibiting PHOSPHORYLATION of RECEPTOR-REGULATED SMAD PROTEINS.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and plays an essential role in EMBRYONIC DEVELOPMENT.
A family of proteins that are involved in the translocation of signals from TGF-BETA RECEPTORS; BONE MORPHOGENETIC PROTEIN RECEPTORS; and other surface receptors to the CELL NUCLEUS. They were originally identified as a class of proteins that are related to the mothers against decapentaplegic protein, Drosophila and sma proteins from CAENORHABDITIS ELEGANS.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and is essential for PHYSIOLOGICAL ANGIOGENESIS.
... conditions inside solid tumors, and results largely from the same mutations in oncogenes and tumor suppressor genes that cause ... Pedersen PL (Feb 2007). "The cancer cell's "power plants" as promising therapeutic targets: an overview". J Bioenerg Biomembr. ... He hypothesized that cancer, malignant growth, and tumor growth are caused by the fact that tumor cells mainly generate energy ... in German). Reprinted in English in the book On metabolism of tumors by O. Warburg, Publisher: Constable, London, 1930. Bertram ...
... tumor-producing Agrobacterium species are pathogenic and do not benefit the plant. The wide variety of plants affected by ... These tumors exert significant pressure on the surrounding plant tissue, which causes this tissue to become crushed and/or ... Performing mandatory inspections of nursery stock and rejecting infected plants as well as not planting susceptible plants in ... even without host plant presence. When there is a host plant present, however, the bacteria enter the plant tissue via recent ...
Plants such as Arabidopsis thaliana express multiple dicer homologs that are specialized to react differently when the plant is ... In many organisms, including humans, miRNAs are linked to the formation of tumors and dysregulation of the cell cycle. Here, ... Numerous studies have demonstrated that RNAi can provide a more specific approach to inhibit tumor growth by targeting cancer- ... Not long after, plant virologists working on improving plant resistance to viral diseases observed a similar unexpected ...
Action against tumors has also been noted. English Names for Korean Native Plants (PDF). Pocheon: Korea National Arboretum. ... 2008). A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential. Oncol ... Geum japonicum, known as Asian herb bennet, is a yellow-flowering perennial plant native to North America and East Asia, ... Plants for a Future. Retrieved April 27, 2012, from http://www.pfaf.org/user/Plant.aspx?LatinName=Geum+japonicum Cheng et al. ( ...
... s are low molecular weight compounds found in plant crown gall tumors or hairy root tumors produced by pathogenic bacteria ... was found in grapevine crown gall tumours and carrot hairy-root cultures. Epileucinopine Epileucinopine (N-(1-carboxy-3- ... It is obtained from crown gall tumors. Saccharopine Although not found in crown gall tumors, saccharopine (epsilon-N-(L-glutar- ... Mannopine Mannopine (N-1-(D-mannityl)-L-glutamine) is found in crown gall tumors. It is the head member of the mannityl family ...
... and is extracted from a plant, Thapsia garganica. It is a tumor promoter in mammalian cells. Thapsigargin raises cytosolic ( ... Since inhibition of SERCA is a mechanism of action that has been used to target solid tumors, thapsigargin has attracted ... type tumor promoter in two-stage mouse skin carcinogenesis". Journal of Cancer Research and Clinical Oncology. 111 (3): 177-181 ... "Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy". Science ...
For example, the tumor-inducing (Ti) plasmid of Agrobacterium and the root-tumor inducing (Ri) plasmid of A. rhizogenes contain ... Infected cells form crown gall or root tumors. The Ti and Ri plasmids are thus endosymbionts of the bacteria, which are in turn ... The expression of these genes effectively transforms the plant cells into opine-producing factories. Opines are used by the ... In laboratories, successful transfers have been reported from bacteria to yeast, plants, mammalian cells, diatoms and isolated ...
So tumors are pushed in as tubers and plants. Although the lexicographic evidence is flimsy, Anttila thinks it is important, ... A hard tumor (scirosis) 'fit ex glutinoso et spisso humore quod confluendo ita membris indigitur ut insitus locis ubi ... the mother Earth which benefits animals and plants'). Grenier thinks that Sol Indiges and the Good Mother Earth (whom he ... considerit unum esse videatur': the tumor is formed by humours that run together to a certain location by pushing the limbs ...
Infected plant cells form crown gall or root tumors. The Ti and Ri plasmids are thus endosymbionts of the bacteria, which are ... tumor). The VirB complex of Agrobacterium tumefaciens is the prototypic system. The nitrogen fixing Rhizobia are an interesting ... Transferred genes enter the plant cell nucleus and effectively transform the plant cells into factories for the production of ... In a plant such as the Venus Flytrap that can make its own food through photosynthesis, it does not eat and digest its prey for ...
Abdel-Fatta Rizk (1990). Poisonous Plant Contamination of Edible Plants. CRC Press. pp. 43-44. ISBN 9780849363696. v t e. ... Phorbol esters are known for their ability to promote tumors. In particular, 12-O-tetradecanoylphorbol-13-acetate (TPA) is used ... "Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action". Nature. 293 (5828): 144-6. ... Plants that contain phorbol esters are often poisonous. Goel, G; Makkar, H. P.; Francis, G; Becker, K (2007). "Phorbol esters: ...
The first indication of a genetic effect on host plant cells came in 1942-1943, where plant cells of secondary tumours were ... Adding A. tumefaciens DNA alone did not cause tumors in plants, while very little A. tumefaciens DNA was found to be integrated ... the resulting product will edit the plant genome without causing any tumours in plants. This method has been used to modify ... The ability of A. tumefaciens to induce crown gall tumours in certain plant species but not others has been attributed to the ...
Second stage tumor promoters like mezerein do not have the capacity to initiate tumors, but can create circumstances in which ... This plant has been used to make dyes, treat rheumatism and indolent ulcers and as a cosmetic. In homeopathy, the plant is used ... Mezerein is a toxic diterpene ester found in the sap of Daphne mezereum and related plants. Plants of the genera Euphorbiaceae ... CS1 maint: discouraged parameter (link) "Daphne mezereum - L." Plants For A Future. Plants For A Future. 2012. Retrieved 28 ...
... and tumors form. The ratio of auxin to cytokinin produced by the tumor genes determines the morphology of the tumor (root-like ... Agrobacterium-induced tumour formation in plants by plant transformation". The EMBO Journal. 29 (6): 1021-32. doi:10.1038/emboj ... Tumors are incited by the conjugative transfer of a DNA segment (T-DNA) from the bacterial tumour-inducing (Ti) plasmid. The ... The disease is characterised by a tumour-like growth or gall on the infected plant, often at the junction between the root and ...
U. maydis is not only used to study plant disease, but it also is used to study plant genetics. In 1996, a study on U. maydis ... Banuett, F. (1995). "Genetics of Ustilago Maydis, A Fungal Pathogen that Induces Tumors in Maize". Annual Review of Genetics. ... The infection causes the corn kernels to swell up into tumor-like galls, whose tissues, texture and developmental pattern are ... Plants, in general, have evolved efficient defense systems against pathogenic microbes. A rapid plant defense reaction after ...
Example petunia plants in which genes for pigmentation are silenced by RNAi. The left plant is wild-type; the right plants ... Solid tumours I Completed Alnylam Pharmaceuticals NCT01158079 siRNA-EphA2-DOPC EphA2 LNP Advanced cancers I Recruiting MD ... miRNAs are linked to the formation of tumors and dysregulation of the cell cycle. Here, miRNAs can function as both oncogenes ... Not long after, plant virologists working on improving plant resistance to viral diseases observed a similar unexpected ...
Example petunia plants in which genes for pigmentation are silenced by RNAi. The left plant is wild-type; the right plants ... Solid tumours I Completed Alnylam Pharmaceuticals NCT01158079 siRNA-EphA2-DOPC EphA2 LNP Advanced cancers I Recruiting MD ... miRNAs are linked to the formation of tumors and dysregulation of the cell cycle. Here, miRNAs can function as both oncogenes ... Jones-Rhoades MW, Bartel DP, Bartel B (2006). "MicroRNAS and their regulatory roles in plants". Annual Review of Plant Biology ...
By transferring the T-DNA into the plant genome, the bacterium essentially reprograms the plant cells to grow into a tumor and ... thus forming the crown gall tumors typically induced by Agrobacterium tumefaciens infection. Whereas Agrobacterium rhizogenes ... The T-DNA is transferred from bacterium into the host plant's nuclear DNA genome. The capability of this specialized tumor- ... Agrobacterium is then used as a vector to transfer the engineered T-DNA into the plant cells where it integrates into the plant ...
In plants[edit]. Significant progress has been made in understanding DNA methylation in the model plant Arabidopsis thaliana. ... Since many tumor suppressor genes are silenced by DNA methylation during carcinogenesis, there have been attempts to re-express ... Furthermore, this study showed that there is a similarity between B cell tumors and long-lived B cells in their DNA methylation ... In plants and other organisms, DNA methylation is found in three different sequence contexts: CG (or CpG), CHG or CHH (where H ...
"Extracellular ATP is a central signaling molecule in plant stress responses". Current Opinion in Plant Biology. 20: 82-87. doi: ... The P2RX7 receptor is overexpressed in most malignant tumors. The expression of the adenosine A2A receptor on endothelial cells ... "New intriguing roles of ATP and its receptors in promoting tumor metastasis". Purinergic Signalling. 9 (4): 487-490. doi: ... In green plants, extracellular ATP and other nucleotides induce an increase in the cytosolic concentration of calcium ions, in ...
Among individuals with NSLC, low expression of the breast cancer 1 gene (BRCA1) in the primary tumor has correlated with ... Psoralens are natural compounds (furocoumarins) present in plants. These compounds intercalate into DNA at 5'-AT sequence sites ... particularly for brain tumors. These agents differ from other crosslinkers as they alkylate O6 of guanine to form an O6- ... DNA repair pathways can result in the formation of tumor cells. Cancer treatments have been engineered using DNA cross-linking ...
Chen X, Irani NG, Firml, J (2011). "Clathrin - mediated endocytosis: the gateway into plant cells". Current Opinion in Plant ... Epsin is thought to have role in the angiogenesis of tumors thus, epsin has the potential to be a target for anti-cancer ... Research indicates that the overexpression could affect the regulation of tumor angiogenesis through defects in the notch ... "The Plant Cell Online. 18 (9): 2258-2274. doi:10.1105/tpc.105.039123. PMC 1560928 .. ...
Radioisotopes are also a method of treatment in hemopoietic forms of tumors; the success for treatment of solid tumors has been ... 2003). "Tumour therapy with radionuclides: assessment of progress and problems". Radiotherapy and Oncology. 66 (2): 107-117. ... For example, one might culture plants in an environment in which the carbon dioxide contained radioactive carbon; then the ... parts of the plant that incorporate atmospheric carbon would be radioactive. Radionuclides can be used to monitor processes ...
Journal of Natural Product and Plant Resources. 6 (2): 13-24.. *^ R.W. Schery. Plants of Man.. Cited in Plants for a Future: ... may have potential to prevent prostate tumor development.[10] ... amurense Bark Extract Prevents Progression of Prostate Tumors ... "Plants of the World Online. Board of Trustees of the Royal Botanic Gardens, Kew. 2017. Retrieved 7 September 2020.. ... Plant as used in Chinese herbology. Note the pictured is a photo of Licorice Root/ GanCao, not Phellodendron. (crude medicine) ...
These gene candidates include certain variations in tumor necrosis factor-alpha (TNF-alpha), IL-1 alpha, and CYP1A1 genes, ... and androgen-secreting tumors, can cause acne in affected individuals.[45][46] Conversely, people who lack androgenic hormones ... Numerous other plant-derived therapies have demonstrated positive effects against acne (e.g., basil oil and oligosaccharides ... as it may increase certain tumors, which has been shown in animal studies, and the caution that "Unnecessary use of this drug ...
In vertebrates and plants, five paralogs of RAD51 are expressed in somatic cells, including RAD51B (RAD51L1), RAD51C (RAD51L2 ... Connell PP, Jayathilaka K, Haraf DJ, Weichselbaum RR, Vokes EE, Lingen MW (2006). "Pilot study examining tumor expression of ... "In Vivo Delivery of miR-34a Sensitizes Lung Tumors to Radiation Through RAD51 Regulation". Mol Ther Nucleic Acids. 4: e270. doi ... Outside of plants and vertebrates, a much broader diversity of Rad51 recombinase paralog proteins exists. In budding yeast, ...
Mutations in maize promoters affect the expression of the promoter genes in a plant-organ-specific manner.[29] A duplication of ... This gene produces PG2 serum, which is used as a biomarker for tumours in gastric cancer. Longer TATA box sequences correlates ... Gaillard J, Haguenauer JP, Romanet P, Boulud B, Gerard JP (November 1977). "[Tumors of the olfactory placode. Study of 5 cases ... "Plant Physiology. 173 (1): 715-727. doi:10.1104/pp.16.01504. PMC 5210749. PMID 27881725.. ...
Yersin looked for the germ responsible for the infection specifically in these plague-spots, tumors caused by the inflammation ... the identification of tumor markers for diagnostic tests and the development of new treatments. One area of particular interest ... Bernard's posthumous essay regarding the nature of the agents implicated in some transformations that happen inside plants, ...
Regulation of plant growthEdit. In plants, signaling by auxins, or phytohormones that order the direction and tropism of plant ... Gankyrin is anti-apoptotic and has been shown to be overexpressed in some tumor cell types such as hepatocellular carcinoma.[81 ... It may lead to brain tumors such as astrocytomas.[95] In some of the late-onset neurodegenerative diseases that share ... Dharmasiri S, Estelle M (2002). "The role of regulated protein degradation in auxin response". Plant Molecular Biology. 49 (3-4 ...
By inhibiting autophagy genes in these tumors cells, regression of the tumor and extended survival of the organs affected by ... Liu, Y.; Bassham, D. C. (2012). "Autophagy: Pathways for Self-Eating in Plant Cells". Annual Review of Plant Biology. 63: 215- ... Tumor cell survival[edit]. Alternatively, autophagy has also been shown to play a huge role in tumor cell survival. In ... There is evidence that emphasizes the role of autophagy both as a tumor suppressor as well as a factor in tumor cell survival. ...
The response of a tumor to radiation therapy is also related to its size. Due to complex radiobiology, very large tumors ... Vulnerability of nuclear plants to attack. *Chernobyl-related articles. *Crimes involving radioactive substances ... It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor ... Additionally, the usual delay between the surgical removal of the tumor and EBRT may allow a repopulation of the tumor cells. ...
... plant cells do not terminally differentiate, remaining totipotent with the ability to give rise to a new individual plant. ... coordinate mRNA expression in normal tissues and overexpression in tumors". Nucleic Acids Res. 27 (11): 2291-8. PMC 148793 . ... "Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells". Int. J. ... While plants do utilise many of the same epigenetic mechanisms as animals, such as chromatin remodeling, it has been ...
... and that this likely originated from the Fukushima power plant.[21] Farmers near the plant dumped raw milk, while testing in ... A pheochromocytoma tumor is seen as a dark sphere in the center of the body (it is in the left adrenal gland). The image is by ... Effluent Releases from Nuclear Power Plants and Fuel-Cycle Facilities. National Academies Press (US). 29 March 2012.. ... It is discharged to the atmosphere in small quantities by some nuclear power plants.[13] ...
In addition to benign tumors, there are in situ tumors and invasive tumors. In situ tumors do not invade the basement membrane ... In oncology: for a carcinoma, in situ means that malignant cells are present as a tumor but have not metastasized, or invaded, ... In chemical engineering, in situ often refers to industrial plant "operations or procedures that are performed in place." For ... This type of tumor can often, depending on where it is located, be removed by surgery. ...
Neoplastic: glioma, meningioma, brain tumors, spinal cord tumors. *Demyelination: multiple sclerosis, disseminated sclerosis, ... Hemiplegia is not a progressive disorder, except in progressive conditions like a growing brain tumour. Once the injury has ... assessment scales may help physiotherapists and other health care professionals during the course of their treatment plant to: ... Hemiparesis and hemiplegia can be caused by different medical conditions, including congenital causes, trauma, tumors, or ...
These effects seem to be largely mediated by mutations at guanine in codon 249 of the p53 gene, a tumor suppressing gene, and ... The mold lives in soil, surviving off dead plant and animal matter, but spreads through the air via airborne conidia. This ... liver tumors, especially given co-infection with hepatitis B virus. ... us), National Center for Biotechnology Information (1998-01-01). The p53 tumor suppressor protein. National Center for ...
mutate, they may cause the cell to multiply uncontrollably, forming a tumor. Although the duration of cell cycle in tumor cells ... In cells with nuclei (eukaryotes), (i.e., animal, plant, fungal, and protist cells), the cell cycle is divided into two main ... in tumors is much higher than that in normal tissue.[citation needed] Thus there is a net increase in cell number as the number ... Because these genes are instrumental in prevention of tumor formation, they are known as tumor suppressors. The cip/kip family ...
Ngema coined "Maske Tumor". The survivors were then subjected to horrific live experimentation. Because Itall never saw Nollin ... Somehow, Itall managed to survived death a second time (presumably because his tumors took the brunt of the gunshots), but his ... Itall complied and hid the Goldstock in a water purification plant before surrendering to authority. After he surrendered, ... Ngema Neubauer (ヌゲマ・ヌーバウアー, Nugema Nūbauā) was the doctor assigned by Kagura Dornburg to find a cure for a strange tumor Kagura ...
Patients whose tumor had an IDH1 mutation had longer survival. Furthermore, mutations of IDH2 and IDH1 were found in up to 20% ... Specific mutations in the isocitrate dehydrogenase gene IDH1 have been found in several brain tumors including astrocytoma, ... Characterization and Activity Regulation during Natural Senescence". Plant Physiol. 121 (3): 921-928. doi:10.1104/pp.121.3.921 ... which results in different gene expression that can activate oncogenes and inactivate tumor-suppressor genes. Ultimately, this ...
This family of proteins is greatly expanded in plants, and constitutes a core component of plant immune systems. The ligands ... Another possible exploitation of PRRs in human medicine is also related to tumor malignancies of the intestines. Helicobacter ... which shows a high potential in treatment of inflammation associated tumors. ... Upon ligand recognition, the plant PRRs transduce "PAMP-triggered immunity" (PTI). Plant immune systems also encode resistance ...
Thus, tumors that express β3-tubulin are not only resistant to the cytotoxic effects of microtubule targeted drugs, but also to ... Plant Cell Biology: From Astronomy to Zoology. Amsterdam: Elsevier/Academic Press, p. 165. Cooper GM (2000). "Microtubule ... Knoblich JA (December 2010). "Asymmetric cell division: recent developments and their implications for tumour biology". Nature ... Some cell types, such as plant cells, do not contain well defined MTOCs. In these cells, microtubules are nucleated from ...
A) Maestro images of HT-29 tumors at 24, 72 and 120 h postadministration and the confocal images of corresponding tumor ... Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice.. Shukla S1, Wen AM, Ayat NR, ... Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice ... Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice ...
Plant Tumors*Plant Tumors. *Plant Tumor. *Tumor, Plant. *Tumors, Plant. *Plant Galls ... "Plant Tumors" by people in Harvard Catalyst Profiles by year, and whether "Plant Tumors" was a major or minor topic of these ... Plant tumors or galls usually form in response to the action of a pathogen or a pest. (Holliday, P., A Dictionary of Plant ... "Plant Tumors" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ...
Neuroendocrine tumors (NETs) represent rare tumors that are derived from cells of the embryonic neural crest. They account for ... Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells. *Authors: * ... The present in vitro study demonstrates the antitumor effects of novel plant derived agents in human neuroendocrine tumor cells ... The plant was originally bought at a market in Vietnam. Aerial parts of the plant were successively extracted in ...
Molecular Plant-Microbe Interactions 13:1034-1040...Julia Krüger , 1 Gabriel Loubradou , 1 Gerhard Wanner , 2 Erika Regenfelder ... tight regulation of the cAMP pathway is crucial for fungal development within the plant but does not interfere with the tumor ... In the resulting tumors, the amount of fungal material is drastically reduced and fungal development is arrested at the stage ... as null mutants in any component of the pathway fail to form tumors. Here we show that moderate activation of the pathway ...
Crown-gall tumor initiation by Agrobacterium tumefaciens is inhibited by cell walls from normal dicotyledonous plants but not ... Cell Walls of Crown-Gall Tumors and Embryonic Plant Tissues Lack Agrobacterium Adherence Sites ... Cell Walls of Crown-Gall Tumors and Embryonic Plant Tissues Lack Agrobacterium Adherence Sites ... Cell Walls of Crown-Gall Tumors and Embryonic Plant Tissues Lack Agrobacterium Adherence Sites ...
Inside tumors, the nanoparticles gather inside the lysosomal compartments of cancer cells, where they are, in essence, digested ... Drug candidate shrinks tumor when delivered by plant virus nanoparticle. Chimica Oggi-Chemistry Today ... The researchers say delivery of the phenanthriplatin into the tumor led to its improved performance over cisplatin or free ... The long, thin tobacco mosaic virus nanoparticles are naturals for delivering the drug candidate into tumors, said Steinmetz, ...
... as this has been argued to be an underappreciated component of PV immunity and clearance of warts and other lesions or tumors ( ... Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study. T. Kohl ... Plant-derived human papillomavirus 16 E7 oncoprotein induces immune response and specific tumor protection. Cancer Res. 62:3654 ... Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study ...
In this study, we evaluated the in vitro cytotoxic anti-tumor and immunomodulatory activities and in vivo anti-tumor effect of ... In vivo anti-tumor activity was evaluated in nude mice bearing subcutaneously human Ando-2 melanoma cells. The LACE extract ... Tumor cell lines derived from leukemias, melanomas, fibrosarcomas and cancers of breast, prostate, cervix, lung, pancreas and ... The intraperitoneal injection or oral administration of LACE extract in nude mice inhibits in vivo tumor growth of Ando-2 ...
Ocn+ cells affect distant tumor progression because experimentally reducing the number of these cells limits lung tumor growth ... Plant Pathology. Plant nutrient acquisition entices herbivore. *. Working Life. The universe in a classroom ... This study identifies systemic cross-talk between lung tumors and bones: Lung tumors can remotely activate Ocn+ osteoblastic ... and their ability to modulate tumor progression. Most tumor-infiltrating myeloid cells derive from circulating precursors, ...
Researchers have said that studying how tumors evolve can help the development of new treatments which can prevent the cancer ... Carcinoid Tumors. Carcinoid tumors is a benign tumor that results in carcinoid syndrome. Only 8 to 10% of all carcinoid tumors ... Health Benefits of Dandelion Plant. What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health ... Brain Tumor. Up to date information about brain tumor, the most common solid tumor in children and the third leading cause of ...
A massive abdominal tumor measuring about 10 kg has been removed from a female patient, by surgeons in the western Croatian ... Health Benefits of Dandelion Plant. What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health ... Potential Drug for Tumors in Childhood and Adult Cancers Found More Cancer News ... Tumor Markers For Cancer Diagnosis and Prognosis. An ideal tumor marker for a cancer should be specific to that cancer and not ...
... in tumors promotes cancer progression by altering signaling in tumor-associated immune cells. ... and a team at Duke University have explored the tumor microenvironment and identified a mechanism by which tumors evade ... in tumors promotes cancer progression by altering signaling in tumor-associated immune cells. The scientists say their study ... The ability of tumors to evade being recognized by the immune system plays a critical role in cancer progression. Now, as ...
Nature Papers Describe CRISPR Plant Editing Methods, DNA-PAINT Improvements, More. In Nature this week: CRISPR approaches to ... used single-cell sequencing to discern copy number patterns in individual cells from primary and metastatic breast tumors. ... Home » Tools & Technology » Sequencing » Single Cell Sequencing Offers Peek into Breast Tumor Evolution ... Single Cell Sequencing Offers Peek into Breast Tumor Evolution. Mar 14, 2011 ...
The p53 gene is a tumor suppressor gene that is most frequently mutated or inactivated in a wide range of human tumors (Levine ... Special issue - plant development. Last autumn we published our special issue on plant development, edited by Ottoline Leyser ... Hall, P. A. and Lane, D. P. (1997). Tumor suppressors: a developing role for p53? Curr. Biol. 7,R144 -R147. ... Interplay between the tumor suppressor p53 and TGFβ signaling shapes embryonic body axes in Xenopus ...
granulosa-theca cell tumor synonyms, granulosa-theca cell tumor pronunciation, granulosa-theca cell tumor translation, English ... dictionary definition of granulosa-theca cell tumor. n. 1. An abnormal growth of tissue resulting from uncontrolled, ... Tumors can be benign (unlikely to spread to other body parts) or malignant (likely to spread). See Note at cancer. ... 2. an uncontrolled, abnormal, circumscribed growth of cells in any animal or plant tissue; neoplasm. ...
Heat shock protein 70 is an antiapoptotic chaperone protein highly expressed in human breast tumors and tumor cell lines. Here ... QnAs with NAS member and plant biologist Sheng Yang He. Image courtesy of Sheng Yang He. ... tumor necrosis factor;. asHsp70,. antisense Hsp70 cDNA;. Hsc70,. heat shock cognate protein;. Ad.asHsp70,. Hsp70 cDNA in ... Furthermore, Bcl-2 and Bcl-XL, which protect tumor cells from most forms of apoptosis, failed to rescue breast cancer cells ...
Upper) Tumor incidence (percent of rats with tumors). (Lower) Tumor multiplicity (no. of tumors/no. of rats at risk). ... Inducer potencies of the sprouts are expressed both "per mg fresh plant weight" (Upper) and "per plant" (Lower). Mean fresh ... with respect to tumor multiplicity (tumors per animal), and incidence (fraction of tumor-bearing animals) (Fig. 5). The tumor ... Inhibition of Mammary Tumor Development in Rats.. Mammary tumors were produced in female Sprague-Dawley rats by feeding single ...
... lifetime chance of these tumors becoming malignant peripheral nerve sheath tumors (MPNSTs). These tumors have a severe ... Integrative analysis identifies candidate tumor microenvironment and intracellular signaling pathways that define tumor ... Integrative analysis identifies candidate tumor microenvironment and intracellular signaling pathways that define tumor ... Integrative analysis identifies candidate tumor microenvironment and intracellular signaling pathways that define tumor ...
... pushing for complete censorship of health impacts in humans and tumors in rats ... "Firstly, it is consumers who will carry the risks associated with genetically engineered plants. And secondly, taxpayers money ... MEDICAL SHOCKER: Scientists at Sloan Kettering discover mRNA inactivates tumor-suppressing proteins, meaning it can promote ... Tumors in the GMO group were also two to three times larger than tumors that developed in the control group (for such studies, ...
Compound combination blocked tumor growth in mice. The compounds were tested on prostate cancer cells derived from mice and ... Previous studies have identified a number of compounds, particularly found in plant-based foods, that have the potential to ... Researchers have identified a number of natural compounds that have the potential to "starve" prostate cancer tumors and shrink ... which prevented tumor growth in the mice. ...
Steve Jobs Died Nearly 10 Years Ago From Pancreatic Neuroendocrine Tumors (pNETs); Treatment Advances Since Have Been ... And earlier this year at the European Neuroendocrine Tumor Society (ENETS) Conference, other advancements were shared. It was ... These included the use of plants, acupuncture, and making dietary changes. However, nine months after the diagnosis, and after ... Jobs and Neuroendocrine Tumors. *Steve Jobs died in 2011 after a battle with pancreatic cancer and neuroendocrine tumors (NETs ...
... the supportive tissue surrounding the tumor), the use of targeted agents, and trials based on tumor type or genetic profiles. ... Matchmakers: How Basket Trials Match Patients With Drugs Based on Their Tumors ...
The R [Roundup] treatment groups showed the greatest rates of tumor incidence with 80% of animals affected with up to 3 tumors ... If modified plants contaminate your crops it could cost you dear. *Environmental Effects of Transgenic Plants: The Scope and ... of female animals had developed tumors in all treated groups, with up to 3 tumors per animal, whereas only 30% of controls were ... Study Links RR Corn to Tumors in Rats. On September 19, 2012, a team led by Gilles-Eric Séralini of the University of Caen ...
4. L-BOAA - Also known as ODAP, this excitotoxin is another naturally occurring chemical found in grass peas and other plants/ ... Further tests in Olneys studies even went on to see if the rising brain tumor rates had any relation to the use of ... Fast Food Linked to Dead Brain Cells, Memory Loss and Brain Tumors. POSTED ON October 2, 2015 BY Sara Wylie ... "exceedingly high incidence" of brain tumors in the rats used for the study? ...
Recent studies have shown that chemotherapy destabilizes the blood vasculature and increases circulating tumor cell (CTC) ... Currently, the first-line treatment used to prolong life expectancy and reduce metastatic tumors in Met-pa is systemic ... However, this effect was not observed in patients receiving other chemotherapy treatments (taxanes, plant alkaloids, ... invasive tumor cells: (i) detach from the primary tumor, (ii) invade into the tumor stroma, (iii) intravasate into the blood ...
5 Mossy Tumors. Mossy Tumor (5) There is a malevolence growing... ... and gather the mossy tumors growing upon them. Bring the tumors ... Patch 4.0.3a (2010-11-23): Quest name changed from Tumors to Mossy Tumors. ... Mossy Tumors. Level: 1-30. Rellian Greenspyre. Rellian Greenspyre. XP: 975 XP. Rep: Darnassus +350. Rewards:. [Pruning Knife]. ... Mossy Tumor] (5). Description. There is a malevolence growing in the timberlings. We are trying to find the source, but until ...
Clinicians Around the World Embracing the CyberKnife System as an Essential Tool to Treat Tumors Anywhere in the Body SUNNYVALE ... s expanded manufacturing plant strengthens the companys R&D efforts. The new facility enables Accuray. to accelerate the pace ... Image guidance and computer controlled robotics combine to continuously track, detect and correct for tumor and patient ... Currently, over 50 percent of the CyberKnife Systems total treatments in the U.S. are conducted on tumors outside the head. ...
Or maybe this tumor is my fault. Maybe its from when I got anorexia, Mum holding me at night when she thought I was asleep and ... She hasnt been this small since Africa, where she knit afghans with local women while Dad taught blind men how to plant and ... I read somewhere that stress can trigger brain tumors. Perhaps Mums grew when she found Nanny in the bathtub, dead. ...
Vegetarian/vegan diets (zinc from plant sources is not absorbed very well) ... com/2017/09/30/stop-cancer-cell-growth-by-getting-concentrations-of-zinc-regularly-destroy-cancer-tumors-with-zinc/ ... Zinc prevents tumor growth and many people lack the nutrient Earlier studies have shown that zinc plays an important role for ...
... extracts from whole-plant marijuana can slow the growth of cancer cells from one of the most serious types of brain tumors." ... Slightly surprising, given the trials on treating fast-growing brain tumours. Its not conclusive, but its way better than ... in the growth of glioma tumors in mice. Glioma accounts for 80 percent of malignant brain tumors in humans. ... Also, behind that label no consistent effect is the fact that some of the mouse tumours showed faster growth...) ...
Data for: Tumor necrosis factor-alpha protein concentrations in bronchoalveolar lavage fluid from healthy horses and horses ... Studies employing extracts or constituents (plant extracts, feed additives or microbiome) must be sufficiently defined to be ... immunology of infectious disease and tumors, immunoprophylaxis including vaccine development and delivery, immunological ... Data for: Tumor necrosis factor-alpha protein concentrations in bronchoalveolar lavage fluid from healthy horses and horses ...
This plant giving small yellow flowers whose scent reminds curry, grows wild in the ... ... Mini Liver Tumours Created in a Dish for the First Time Rajkumar R 11:56 0 ...
tumor - n. a mass of tissue in the body that is made up of cells that are not normal ... Experts say since most tumors form in soft tissue that does not easily fossilize, there is little evidence of cancer in the ... It was a four-legged plant eating animal about 6 meters long that lived between 76 and 77 million years ago. ... They said they were able to confirm that the growth was a tumor by using computed tomography, or CT, images. CT technology uses ...
... such as a tumor, it could then deliver the drug to just that specific location, making the drug more effective, or reducing ... co-author and plant sciences and pathology professor at MSU. ... or even tumors, in the future. ...
Some evidence of tumors in the brains of male rats; the tumors were malignant gliomas. Some evidence of tumors in the adrenal ... After it was removed, they identified it as a benign parotid gland tumor. She later found that this type of tumor is found with ... How Does EMF Affect Plants And Animals?. Plant signaling and behavior NCBI journal [18]. The experiments found two major ... "Clear evidence of tumors in the hearts of male rats; the tumors were malignant (extremely severe or harmful in its effects) ...
Brain tumor education, support, and inspiration.. Search for: Recent Posts. * Someone Saved My Life Tonight ... But finding preventative treatments and the cure for brain tumors is my new passion. And knowing how my neurosurgeon plans to ... Brain tumorresearchseed fundingYale - New Haven Hospital. Post navigation. Previous PostIts A Beautiful DayNext PostThe ... One thought on "Planting The "Seeds" To A Cure" * Pingback: Let The Music Do The Talking , Grey Matters ...
The rare tumor mainly affects young people and can be fatal. The authors said the number of cases was so small - just three ... But Valent and others whove been affected by the high occurrence of rare tumors there want the state to take a closer look. ... The district includes a former radium and uranium plant in Canonsburg. The old Standard Chemical Company site, where more than ... "He had a very small tumor in his shoulder. But he had a mass in his liver - it was in his liver, lungs, lymph node and spleen ...
... managed to shrink his tumors in half after being diagnosed with lung cancer and refusing traditional cancer treatment such as ... CBD oil is a non-psychoactive phytocannabinoid found in cannabis plants (or Cannabis sativa). It has been shown to aid users in ... During the period of the time in which the tumors shrunk, there were no notable changes in the mans diet, lifestyle, or ... After three months of almost daily use, scans of the mans lungs showed that, not only did the tumors reduce in size by half, ...
Common Plant Fiber Gel Doubled Rate of Tumor Eradication 07/02/2021 / ... Abigail Klein Leichman via Israel21c - Changing the gut microbiome can reprogram the immune system to attack malignant tumors, ... Researchers Engineer Cells to Destroy Malignant Tumor Cells but Leave the Rest Alone ... A novel CAR T-cell therapy developed by researchers at UCL and designed to target cancerous tumours, has shown promising early… ...
... a plant virus that does not infect mammals, is recognized by the immune system. ... when injected into cancerous tumors, strongly stimulated the immune system to attack and often eliminate the tumor. However, ... This plant virus is recognized by the immune system as a pathogen-any infectious agent that can cause disease. When tumors are ... very little was understood about how an immune system can recognize a plant virus, and how and why this plant virus is ...
Humanity has planted flags on the moon, but a moon shot for brain cancer has yet to be realized. ... Humanity has planted flags on the moon, but a moon shot for brain cancer has yet to be realized. ... In the brain, where critical human functions are packed into millimeters of tissue, removing more tumors and potentially ... In glioblastoma, tumor cells that are inches away from most of the tumor and far beyond the reach of tweezers almost guarantee ...
Cannabis & Tumor Size Reduction. While there is great interest in the use of cannabis to shrink tumors, Victoria is cautious ... "Breeders breed certain plants for certain effects," she explains. "Unless you pull the plant and extract all the contents, you ... Cannabis & Tumor Size Reduction. While there is great interest in the use of cannabis to shrink tumors, Victoria is cautious ... "Breeders breed certain plants for certain effects," she explains. "Unless you pull the plant and extract all the contents, you ...
from our previous research had succeded to examp by using activity in vitro antiproliverati from extract plant (nusa indah, ... Induced Mammary Tumors in BALB/c mice. ... tumor mammae Abstract. Tumor or neuplasm can be meant as a ... Tumor induction with (MNO) at mammary gland will occur allegic reaction inflammatory which is the beginning of tumor mechanism ... Enhanced Migration of Tumor Cells In Respon To Collagen Degradation Product and Tumor Cell Colagenolytic Activity. Invasion and ...
Plant-derived phenolic compounds (such as ferulic acid) were reduced in the HPLC diet, but increased in the HPMC diet compared ... By decreasing the number of carbs eaten, there is much less glucose in the body that tumors can use to grow.. A study published ... 58 percent protein and 26 percent fat had slower tumor cell growth than mice that ate a typical Western diet of 55 percent ... It could also reduce cancer risk and slow growth of tumors, according to a new study in mice. During their first year of life, ...
2 Description 3 Progress 4 Completion 5 Reward 6 Progression 7 Patch changes 8 External links Collect the Gargantuan Tumor... ... 1-30] Planting the Heart. *. [1-30] Rellian Greenspyre. *. [1-30] Mossy Tumors ... Gargantuan Tumor]. Description. I figured it out! I had to rush here to find you! Its so simple really... the corruption has ... The size of this tumor is quite disturbing, but I must study it to learn more about the disease that upsets the timberling ...
Feed your nerve plants once a month or every other month during spring and summer. Shop Today! Nerve Sheath Tumor Average Cost ... It s tummy won t be your cat from nibbling on them variety fittonia! Nerve sheath tumors to drain completely those who wish ... Growing nerve plants is easy and so is nerve plant care. So be sure to protect your fittonia plant from cold drafts. In USDA ... Boston fern, bamboo palm, and snake plant are all safe plants and are topnotch air pollutant filters. Another plant with ...
We blend the finest cannabis flowers from across Canada to create this unique whole plant theory of Omega 8.The healing ... Mechanisms of cannabinoid action against brain tumors. Marijuana against breast cancer. *Modulation of the tumor ... It is known that the marijuana plant can help in a natural way and relieve symptoms of cancer and chemotherapy: pain relief, ... Anti-tumor effects of marijuana. Updated publications on the website of the National Cancer Institute of the Government of the ...
  • In addition, triterpenoid saponins inhibited tumor growth and induced the apoptosis of HCC cells by blocking the activation of PD1/PD-L1, ERK1/2, p38 MAPK, JNK, and STAT3 signaling pathways. (dovepress.com)
  • While up to 30% of the PVX signal was from the colon, mammary and brain tumor tissues, remaining particles were cleared by the reticuloendothelial system organs (the spleen and liver), followed by slower processing and clearance through the kidneys and bile. (nih.gov)
  • Cell walls from normal and tumor tissues in culture also show this difference, indicating that the two types of tissue stably maintain this difference under these conditions. (sciencemag.org)
  • Crown-gall tumors thus resemble embryonic tissues in this respect. (sciencemag.org)
  • Sulforaphane induces several phase 2 enzymes in both cultured cells and mouse tissues ( 15 ), blocks 7,12-dimethylbenz( a )anthracene (DMBA)-initiated mammary tumor formation in rats ( 16 ), and inhibits neoplastic nodule formation in cultured mouse mammary glands ( 17 ). (pnas.org)
  • Immunofluorescence, flow cytometry, and western blot were performed to analyze the effect of triterpenoid saponins on immune response in tumor tissues. (dovepress.com)
  • Metabolomic analysis was carried out to assess the metabolites involved in mediating the effect of triterpenoid saponins on tumor tissues. (dovepress.com)
  • However, it's difficult to heat patients' tumors without damaging nearby tissues. (phys.org)
  • Another advantage of the nanorods is that by coating them with different types of light-scattering molecules, they can be designed to simultaneously gather multiple types of information - not only whether there is a tumor, but whether it is at risk of invading other tissues, whether it's a primary or secondary tumor, or where it originated. (phys.org)
  • Radiation damages normal surrounding tissues as well as the intended tumor. (greenmedinfo.com)
  • They also invade surrounding tissues and are metastatic, initiating the growth of similar tumors in distant organs. (thefreedictionary.com)
  • We have used a metabolite profiling approach to test the hypothesis that quantitative signatures of primary metabolites can be used to characterize molecular changes in ovarian tumor tissues. (aacrjournals.org)
  • Up to 1,000 individual metabolites could be retrieved from plant tissues using time-of-flight (TOF) MS concomitant with deconvolution software to identify individual compounds based on detection of model ions even in those cases where the individual mass spectra of two or more compounds overlap ( 7 ). (aacrjournals.org)
  • The combination of gas chromatography-TOF (GC-TOF)-based analysis with automatical deconvolution techniques has not been used for analysis of human tumor samples, thus far, but only on mouse tissues in obesity-related research ( 12 ). (aacrjournals.org)
  • Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. (nih.gov)
  • Here, we present a detailed analysis of PVX biodistribution and clearance in healthy mice and mouse tumor xenograft models using a combination of ex vivo whole-organ imaging, quantitative fluorescence assays and immunofluorescence microscopy. (nih.gov)
  • Triple-negative breast cancer tumors of mice treated with the phenanthriplatin -carrying nanoparticles were four times smaller than those treated either with cisplatin, a common and related chemotherapy drug, or free phenanthriplatin injected intravenously into circulation. (teknoscienze.com)
  • In vivo anti-tumor activity was evaluated in nude mice bearing subcutaneously human Ando-2 melanoma cells. (biomedcentral.com)
  • The intraperitoneal injection or oral administration of LACE extract in nude mice inhibits in vivo tumor growth of Ando-2 melanoma cells and prolongs the survival day of the mice. (biomedcentral.com)
  • The LACE extract presented in vivo anti-tumoral activity in nude mice against tumor growth of Ando-2 melanoma cells. (biomedcentral.com)
  • An HCC model was established in H22 tumor-bearing mice and triterpenoid saponins were administered at various doses. (dovepress.com)
  • Human tumors transplanted into laboratory mice disappeared or shrank when scientists treated the animals with a single antibody, according to a new study from the Stanford University School of Medicine. (medicalxpress.com)
  • In a study reported in the team's Cancer Research paper, tumors in mice that received an intravenous injection of nanorods plus near-infrared laser treatment disappeared within 15 days. (phys.org)
  • Antitumor effects of dietary black and brown rice brans in tumor-bearing mice: Relationship to composition. (greenmedinfo.com)
  • Agaricus brasiliensis appears to have beneficial effects related to cachexia in the treatment of tumor-bearing mice. (greenmedinfo.com)
  • AHCC attenuates cisplatin (chemotherapy) induced side effects in tumor-bearing mice. (greenmedinfo.com)
  • Furthermore, orthotopic implantation of ADAM12-expressing MCF7 cells in nude mice produced tumors with increased levels of activated MMP-14 and confirmed that ADAM12 protects tumor cells against apoptosis, leading to increased tumor progression. (biologists.org)
  • But recent studies in mice show that when treatment stops, tumor growth rapidly resumes. (bio-medicine.org)
  • Kubota and his team compared the efficacy of inhibitors against M-CSF and VEGF in mice with a certain kind of bone tumor. (bio-medicine.org)
  • Tumor growth in mice on a similar regiment of an M-CSF inhibitor remained suppressed in the absence of drug. (bio-medicine.org)
  • We also determined the effects of dietary γ-TmT on the formation and growth of LNCaP tumors in immunodeficient mice. (mdpi.com)
  • In the animal study, treatment of severe combined immunodeficient (SCID) mice with dietary γ-TmT inhibited the formation and growth of LNCaP xenograft tumors in a dose-dependent manner. (mdpi.com)
  • In vivo , the P2Et fraction induced primary tumor reduction in terms of diameter and weight in BALB/c mice transplanted with 4T1 cells and decreased numbers of metastatic cells, mainly in the spleen. (biomedcentral.com)
  • Now, as discussed in the current issue of the Journal of Clinical Investigation , Gerard Blobe, M.D., Ph.D., and a team at Duke University have explored the tumor microenvironment and identified a mechanism by which tumors evade detection. (genengnews.com)
  • Simultaneously, PDT is capable of eliciting various effects in the tumour microenvironment thereby affecting the tumour-associated/-infiltrating immune cells and by extension, leading to infiltration of various immune cells (e.g. neutrophils) into the treated site. (springer.com)
  • Therefore, it seems that PDT is unique among other approved therapeutic procedures in generating a microenvironment suitable for development of systemic anti-tumour immunity. (springer.com)
  • This review mainly discusses the effects exerted by PDT on cancer cells, immune cells as well as tumour microenvironment in terms of anti-tumour immunity. (springer.com)
  • We demonstrate that Sema3A secreted within the tumor microenvironment (TME) suppresses tumor-specific CD8+ T cell function via Neuropilin-1 (NRP1), a receptor that is upregulated upon activation with T cells' cognate antigen. (biorxiv.org)
  • The P2Et fraction exerts its activity on the primary tumor, reduces cell migration to distant organs, and decreases IL-6 serum levels, implying tumor microenvironment mechanisms. (biomedcentral.com)
  • Soluble mediators may be exchanged between tumor cells and their microenvironment, affecting tumor growth and promoting metastases. (biomedcentral.com)
  • These results show that molecular analyses of patient samples can add to the information about the tumor and help us in tracking back the progression of the disease," the authors concluded. (medindia.net)
  • The ability of tumors to evade being recognized by the immune system plays a critical role in cancer progression. (genengnews.com)
  • Using mouse models of breast cancer and melanoma, they show that loss of the Type III TGF-β receptor (TGFBR3) in tumors promotes cancer progression by altering signaling in tumor-associated immune cells. (genengnews.com)
  • Impaired apoptosis signaling is common in cancer cells and may play an important role in tumor initiation and progression ( 1 - 4 ). (pnas.org)
  • It's enough to significantly accelerate tumor progression in our mouse model. (oncologynurseadvisor.com)
  • Several treatment alternatives are available for primary breast cancer, although those for metastatic disease or inflammation associated with tumor progression are ineffective. (biomedcentral.com)
  • The present study evaluated cytotoxic, antitumor, and tumor progression activities of a gallotannin-rich fraction derived from Caesalpinia spinosa (P2Et). (biomedcentral.com)
  • Overall, the P2Et fraction lessens risk factors associated with tumor progression and diminishes primary tumor size, showing good potential for use as an adjuvant in breast cancer ER(+) treatment. (biomedcentral.com)
  • NEW YORK (GenomeWeb News) - Researchers from the US and Canada reported online in Nature yesterday that they have successfully used single-cell sequencing to discern copy number patterns in individual cells from primary and metastatic breast tumors. (genomeweb.com)
  • Our study shows that a deficiency in vitamin D levels, or an inability of tumor cells to respond appropriately to the presence of vitamin D, is sufficient to trigger non-metastatic cancer cells to become metastatic," stated Feldman. (oncologynurseadvisor.com)
  • The parameters evaluated in vivo were tumor growth, leukocyte number, metastatic cell number, and cytokine production by flow cytometry. (biomedcentral.com)
  • Interestingly, Hsp70 rescues cells from apoptosis induced by, e.g., tumor necrosis factor (TNF), without inhibiting the activation of effector caspases ( 19 ). (pnas.org)
  • The current study used genetically engineered neural stem cells - cells that have the potential to differentiate into any of several types of cells of the central nervous system - to deliver a protein that is known for its cancer-fighting properties: tumor necrosis factor related apoptosis inducing ligand, or TRAIL. (innovations-report.com)
  • For this reason necrosis and ulceration are characteristic of malignant tumors. (thefreedictionary.com)
  • Heat shock protein 70 is an antiapoptotic chaperone protein highly expressed in human breast tumors and tumor cell lines. (pnas.org)
  • The Gynecologic Oncology Group (GOG) is currently conducting a randomized phase II trial (Clinical trial ID: NCT104522) comparing BEP with carboplatin and paclitaxel for patients with advanced or recurrent chemotherapy-naive sex cord stromal tumors. (medscape.com)
  • In 1999, Homesley et al reported the Gynecologic Oncology Group's experience using this regimen and included patients with all types of ovarian sex cord-stromal tumors, although 48 patients had GCTs. (medscape.com)
  • In contrast to invasive carcinomas, borderline tumors lack a destructive stromal invasion. (aacrjournals.org)
  • Furthermore, Bcl-2 and Bcl-X L , which protect tumor cells from most forms of apoptosis, failed to rescue breast cancer cells from asHsp70-induced death. (pnas.org)
  • Resistance of cancer cells to apoptosis is especially deleterious because it not only enhances the spontaneous growth of tumors but also renders them resistant to host defense mechanisms as well as various forms of therapy. (pnas.org)
  • In addition to its preferential expression in tumors and its ability to inhibit apoptosis, the role of Hsp70 in tumorigenesis is supported by data showing that its expression enhances the tumorigenic potential of rodent cells in vivo ( 20 - 22 ). (pnas.org)
  • Earlier results of a preliminary nature have suggested that the inhibition of Hsp70 synthesis in tumor cells may either sensitize them to chemotherapy or commit them to apoptosis ( 19 , 27 , 28 ). (pnas.org)
  • Subsequent to this activation, gelatin degradation was stimulated and tumor-cell apoptosis was decreased, with reduced expression of the pro-apoptotic proteins BCL2L11 and BIK. (biologists.org)
  • Mechanistic studies showed that γ-TmT administration inhibited proliferation as reflected by decreased mitosis and stimulated apoptosis as reflected by increased caspase-3 (active form) expression in LNCaP tumors. (mdpi.com)
  • Hsp70 is abundantly expressed in malignant human tumors of various origins, whereas in normal cells, its expression is mainly stress inducible. (pnas.org)
  • Scientists at the Genome Institute of Singapore (GIS) have unraveled the mechanism that causes liver cancer (hepatocellular carcinoma, HCC), one of the most common solid tumors worldwide. (medicalxpress.com)
  • Testicular germ cell cancer, a disease that is rare but growing in incidence in men in the United States, is considered to be among the most curable of solid tumors. (news-medical.net)
  • Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption. (greenmedinfo.com)
  • In younger women and women with dense breasts, MRI is effective in the detection of what are known as multicentric cancers, meaning breast cancers involving 2 or more distinct primary tumors, usually in different quadrants of the breast. (oncologynurseadvisor.com)
  • The immunomodulating effect and anti-tumor activity of many kinds of plant polysaccharides are introduced in this article. (cnki.com.cn)
  • Neuroendocrine tumors respond poorly to radiation and conventional chemotherapy, hence surgical removal of the neoplastic tissue is still the most effective way of treatment. (spandidos-publications.com)
  • The patient in the study received conventional treatment, which included surgical removal of his tumors, radiation therapy and chemotherapy, and participation in a clinical trial. (medindia.net)
  • Most of those patients are treated with chemotherapy and/or radiation, which are often effective but can have debilitating side effects because it's difficult to target tumor tissue. (phys.org)
  • With chemotherapy treatment, 99 percent of drugs administered typically don't reach the tumor, said von Maltzahn. (phys.org)
  • Additionally, heating them to a lower temperature weakens tumor cells enough to enhance the effectiveness of existing chemotherapy treatments, raising the possibility of using the nanorods as a supplement to those treatments. (phys.org)
  • Tumours of that size are almost always benign, but can kill by severing circulation or increasing pressure on sensitive parts of the body. (medindia.net)
  • Tumors can be benign (unlikely to spread to other body parts) or malignant (likely to spread). (thefreedictionary.com)
  • A brain tumor, though benign, combined with a rare and painful autoimmune disorder led to a prognosis that nobody, let alone a driven and fiery 30-something, wants to hear. (vegnews.com)
  • Tumors are classified in a number of ways, one of the simplest being according to their origin and whether they are malignant or benign. (thefreedictionary.com)
  • Benign tumors do not endanger life unless they interfere with normal functions of other organs or affect a vital organ. (thefreedictionary.com)
  • Gross appearance of benign (A) and malignant (B) tumors. (thefreedictionary.com)
  • Neuroendocrine tumors (NETs) represent rare tumors that are derived from cells of the embryonic neural crest. (spandidos-publications.com)
  • These tumors are composed of embryonic, primitive, or poorly differentiated cells. (thefreedictionary.com)
  • Now, MIT researchers have developed tiny gold particles that can home in on tumors, and then, by absorbing energy from near-infrared light and emitting it as heat, destroy tumors with minimal side effects. (phys.org)
  • This class of particles provides the most efficient method of specifically depositing energy in tumors," he said. (phys.org)
  • In designing the particles, the researchers took advantage of the fact that blood vessels located near tumors have tiny pores just large enough for the nanorods to enter. (phys.org)
  • In this study, we evaluated the in vitro cytotoxic anti-tumor and immunomodulatory activities and in vivo anti-tumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae) . (biomedcentral.com)
  • An aqueous extract of Calendula Officinalis was obtained by a novel extraction method in order to measure its anti-tumor and immunomodulatory activities in vitro . (biomedcentral.com)
  • Tumor cell lines derived from leukemias, melanomas, fibrosarcomas and cancers of breast, prostate, cervix, lung, pancreas and colorectal were used and tumor cell proliferation in vitro was measured by BrdU incorporation and viable cell count. (biomedcentral.com)
  • The LACE extract showed a potent in vitro inhibition of tumor cell proliferation when tested on a wide variety of human and murine tumor cell lines. (biomedcentral.com)
  • These results indicate that LACE aqueous extract has two complementary activities in vitro with potential anti-tumor therapeutic effect: cytotoxic tumor cell activity and lymphocyte activation. (biomedcentral.com)
  • The aim of the present study was to evaluate the in vitro cytotoxic anti-tumor and immunomodulatory activities of a novel extract of the plant Calendula Officinalis (LACE: Laser Activated Calendula Extract). (biomedcentral.com)
  • In vitro studies demonstrated that unmodified TRAIL cells quickly attacked human glioblastoma cells, with nearly all of the tumor cells being killed within 24 hours. (innovations-report.com)
  • This article introduces a systematic review of effective natural plant compounds and their extract that modulates the pathological EMT or its deleterious effects, through acting on different cellular signal transduction pathways both in vivo and in vitro . (frontiersin.org)
  • One example of it is the secretion of an extra, cellular amylase by the tissue of a virus-induced tumor from the root of Rumex wetosa L. An amylase is secreted in sufficient quantities by this tissue to enable it to grow as well in vitro on a starch-containing medium as on one containing sucrose. (unl.edu)
  • Any tissue that lights up, other than the liver or spleen, could harbor an invasive tumor. (phys.org)
  • Sixty-six invasive ovarian carcinomas and nine borderline tumors of the ovary were analyzed by gas chromatography/time-of-flight mass spectrometry (GC-TOF MS) using a novel contamination-free injector system. (aacrjournals.org)
  • It has long been recognized that besides invasive ovarian carcinoma, a different type of lesion exists in the ovary, the so-called borderline tumor (review ref. 14 ). (aacrjournals.org)
  • The different biological background of borderline tumors and invasive ovarian carcinomas translates into different clinical behavior of both groups of tumors. (aacrjournals.org)
  • The normal immunity system can identify and kill tumor cells, however, the occurrence rate of tumor will enhance if it lacks of the ability of immunologic defence or immunological recognition. (cnki.com.cn)
  • It has also come to light that, PDT is capable of activating 'anti-tumour adaptive immunity' in both pre-clinical as well as clinical settings. (springer.com)
  • Castano AP, Mroz P, Hamblin MR (2006) Photodynamic therapy and anti-tumour immunity. (springer.com)
  • Semaphorin-3A (Sema3A) regulates tumor angiogenesis, but its role in modulating anti-tumor immunity is unclear. (biorxiv.org)
  • Our study establishes Sema3A as a potent inhibitor of anti-tumor immunity. (biorxiv.org)
  • MTCs are calcitonin producing tumors arising from the parafollicular C-cells and occur in ~4-10% of all thyroid tumors ( 2 ). (spandidos-publications.com)
  • In a previous study, pheophorbid-a, a chlorophyll derivative in Christia vespertilionis plant extracts showed high antiproliferative activity in MTC cells ( 13 ). (spandidos-publications.com)
  • The elongated shape of the nanoparticle causes it to tumble along the margins of blood vessels, remain unnoticed by immune cells and pass through the leaky vasculature of tumors and accumulate inside. (teknoscienze.com)
  • Inside tumors, the nanoparticles gather inside the lysosomal compartments of cancer cells, where they are, in essence, digested. (teknoscienze.com)
  • The scientists say their study also supports the use of TGF-β inhibitors to enhance the efficacy of therapies that promote immune-mediated elimination of tumor cells. (genengnews.com)
  • Work with the murine models demonstrated that the loss of tumor-expressed TGFBR3/sTGFBR3 enhanced TGF-β signaling within locoregional dendritic cells (DC). (genengnews.com)
  • Myrosinase (see ref. 18 ) is normally segregated from glucosinolates and is released when plant cells are injured. (pnas.org)
  • Triterpenoid saponins induced anti-tumor immune response by decreasing the number of Treg cells, increasing that of B cells, natural killer cells, and CD3 + /CD28 + T cells, and reducing the secretion of inflammatory factors including nuclear factor-κB, cyclooxygenase-2, and microsomal prostaglandin E synthase-1. (dovepress.com)
  • Researchers at Cedars-Sinai Medical Center s Maxine Dunitz Neurosurgical Institute in Los Angeles have combined a special protein that targets cancer cells with neural stem cells (NSC) to track and attack malignant brain tumor cells. (innovations-report.com)
  • Furthermore, cells separate from the main tumor and migrate to form satellites that escape treatment and often lead to recurrence. (innovations-report.com)
  • By engineering neural stem cells to secrete interleukin 12, they were able to elicit a local immune response that attacked cancer cells at the tumor site and in the satellites. (innovations-report.com)
  • A week after treatment, strong secretion of TRAIL was visible in the main tumor mass and in disseminating tumor pockets and satellites, indicating that the engineered cells were actively tracking tumor cells. (innovations-report.com)
  • PhysOrg.com) -- It has long been known that heat is an effective weapon against tumor cells. (phys.org)
  • During a single exposure to a near-infrared laser, the nanorods heat up to 70 degree Celsius, hot enough to kill tumor cells. (phys.org)
  • The nanorods could also be used to kill tumor cells left behind after surgery. (phys.org)
  • A mixture containing ascorbic acid, lysine, proline and green tea extract inhibits angiogenesis of tumor cells. (greenmedinfo.com)
  • Xingyun Qi , Roman Pleskot , Niloufer G. Irani and Daniël Van Damme look back at the stimulating and lively discussions on the mechanism and functions of endocytosis in plant cells, with an aim to bridge the gap in knowledge about the endocytic machinery and its cargos in the plant field. (biologists.org)
  • its cells also show a lesser degree of anaplasia than those of a malignant tumor do. (thefreedictionary.com)
  • Finally, using a clear cell renal cell carcinoma patient cohort, we demonstrate that human tumor-specific CD8+ T cells express NRP1 and are trapped in Sema3A rich regions of tumors. (biorxiv.org)
  • Therefore, there is a great need for new therapeutic alternatives capable of generating an immune response against residual tumor cells, thus contributing to eradication of micrometastases and cancer stem cells. (biomedcentral.com)
  • The secretion of extracellular enzymes by intact cells of higher plants apparently is a rare occurrence. (unl.edu)
  • CV extracts showed antiprolife-rative and proapoptotic effects in all MTC and SI-NET cell lines, whereby high growth inhibition was observed by treatment with the ethylacetate-extracts (CV-45) in tumor cell lines but not in normal human fibroblasts. (spandidos-publications.com)
  • Schmidt have exhibited anti-cancer properties and exerted remarkable inhibitory effects on tumor growth. (dovepress.com)
  • Plants have provided a new avenue in curbing tumor growth. (news-medical.net)
  • This study, published in Endocrinology , also demonstrated a correlation between serum vitamin D levels and inhibitor of differentiation 1 (ID1), a tumor growth gene known to be correlated with breast cancer tumors and metastases. (oncologynurseadvisor.com)
  • Researchers ablated the vitamin D receptor in a cell culture model of breast cancer and discovered accelerated primary tumor growth and increased metastases. (oncologynurseadvisor.com)
  • Now, Yoshiaki Kubota and colleagues find that blocking a different molecule, called M-CSF, suppressed tumor growth even after treatment was stopped. (bio-medicine.org)
  • Three weeks of anti-VEGF treatment suppressed tumor growth but, similar to other recent reports, the tumors bounced back when the drug treatment was curtailed. (bio-medicine.org)
  • A massive abdominal tumor measuring about 10 kg has been removed from a female patient, by surgeons in the western Croatian town of Gospic. (medindia.net)
  • A University of Miami doctor recently removed two cancerous tumors from a patient's liver using only three needle-like probes, a computer and a powerful burst of electricity. (medicalxpress.com)
  • Most likely, the antiM-CSF treatment had a lasting effect because it resulted in damage to the scaffolding that surrounds cancerous vessels, robbing the tumors of the structural support they need to grow. (bio-medicine.org)
  • In a pair of firsts, researchers at Case Western Reserve University and Massachusetts Institute of Technology have shown that the drug candidate phenanthriplatin can be more effective than an approved drug in vivo, and that a plant-virus-based carrier successfully delivers a drug in vivo. (teknoscienze.com)
  • The present invention relates to compositions that enhance or inhibit the interactions of galectin-8 and galectin-8-like proteins with other extracellular matrix proteins or cell surface receptors, to the use thereof as physiological modulators of cell adhesion and in treatment of tumors, either in vivo or ex vivo. (google.com)
  • Analysis of his tumors following surgeries, biopsies and autopsy revealed several genetic aberrations, including multiple copies of a region on chromosome 4q, which includes the KIT gene. (medindia.net)
  • Additional findings included the loss of the gene PKP4, which is associated with increased tumor size. (medindia.net)
  • p53 protein functions as a sequence-specific transcription factor and its tumor suppressor function is attributed to its ability to regulate gene expression. (biologists.org)
  • A new study has shown that survival rates among patients with glioma double if the tumor carries a methylated MGMT gene. (news-medical.net)
  • NEWS, 26 March 2010] Gene therapy on a tomato gene could be of value in future treatment of brain tumors, according to a new study from Karolinska Institutet and Lund University. (ki.se)
  • Bayer's new Vitrakvi for tumors with NTRK gene fusions is meeting skepticism in England and Germany, where cost watchdogs on Friday rejected it. (fiercepharma.com)
  • A localized proliferation of plant tissue forming a swelling or outgrowth, commonly with a characteristic shape and unlike any organ of the normal plant. (harvard.edu)
  • Habituated tissue cultures, which resemble crown-gall tumor cultures, however, form cell walls that are inhibitory like those of the normal cultures from which they are derived. (sciencemag.org)
  • Tumors are also called neoplasms , which means that they are composed of new and actively growing tissue. (thefreedictionary.com)
  • The Occlusin 500 Artificial Embolization Device (OCL 500) is a microspherical embolization agent approved for the treatment of highly vascularized, unresectable tumors, e.g., hepatocellular carcinoma or renal cell carcinoma. (medgadget.com)
  • In an attempt to find new therapeutic plant extracts of Christia vespertilionis (CV) their antitumor potential in human medullary thyroid carcinoma (MTC) and human small intestinal neuroendocrine tumor (SI-NET) cell lines were tested. (spandidos-publications.com)
  • In general, the essential oils from young and adult leaves of E. benthamii presented cytotoxicity against the investigated tumor cell lines which confirms their antitumor potential. (hindawi.com)
  • Golab J, Wilczynski G, Zagozdzon R et al (2000) Potentiation of the anti-tumour effects of Photofrin-based photodynamic therapy by localized treatment with G-CSF. (springer.com)
  • Borderline tumors represent 5% to 10% of ovarian epithelial tumors. (aacrjournals.org)
  • Sema3A inhibits T cell migration, assembly of the immunological synapse, and tumor killing. (biorxiv.org)
  • Despite the apoptotic morphology as judged by electron microscopy, the asHsp70-induced death was independent of known caspases and the p53 tumor suppressor protein. (pnas.org)
  • The results indicate that Christia vespertilionis could serve as an anticancer therapeutic for treatment of neuroendocrine tumors. (spandidos-publications.com)
  • Plants have a long history of use in the treatment of cancer. (biomedcentral.com)
  • Patients usually die from a local recurrence of the tumor, even after aggressive treatment. (medindia.net)
  • Although their pharmacological or toxicological properties have not been thoroughly investigated, infusions and decoctions of Eucalyptus plants are widely used in the treatment of respiratory diseases, for example, common cold, influenza, and sinus congestion [ 3 , 4 ]. (hindawi.com)
  • These pictures clearly show that this patient, with previously treatment-resistant tumors, continues to make obvious improvement. (theweedblog.com)
  • The tumors appear to be dying and then healing after treatment with cannabis-based extracts. (theweedblog.com)
  • The results show that multicentric cancer detected on breast MRI after mammography appears to represent a larger tumor burden in approximately a quarter of patients and can result in potential changes to cancer grade and treatment," Iacconi said. (oncologynurseadvisor.com)
  • Help advance the understanding and treatment of brain tumors. (abta.org)
  • The researchers say delivery of the phenanthriplatin into the tumor led to its improved performance over cisplatin or free phenanthriplatin. (teknoscienze.com)
  • Researchers at Translational Genomics Research Institute (TGen) and Scottsdale Healthcare said that studying how tumors evolve can help the development of new treatments which can prevent the cancer from recurring. (medindia.net)
  • TGen researchers tracked several years of tumor evolution in a 47-year-old male patient with maxillary sinus carcinoma (MSC), a rare cancer of the sinus cavities beneath the cheeks that often requires surgical removal that is disfiguring. (medindia.net)
  • The researchers concluded that if TGF-β expression is inhibited, this would provide a novel method of tumor immunotherapy and that "sTGFBR3 levels could serve as a predictive immunotherapy biomarker. (genengnews.com)
  • Researchers compared the association between diets high in plant-based omega-3 polyunsaturated fatty acids (PUFAs) vs those high in marine-based PUFAs and the risk for breast cancer. (oncologynurseadvisor.com)
  • Glucosinolates and isothiocyanates can be efficiently extracted from plants, without hydrolysis of glucosinolates by myrosinase, by homogenization in a mixture of equal volumes of dimethyl sulfoxide, dimethylformamide, and acetonitrile at −50°C. Extracts of 3-day-old broccoli sprouts (containing either glucoraphanin or sulforaphane as the principal enzyme inducer) were highly effective in reducing the incidence, multiplicity, and rate of development of mammary tumors in dimethylbenz( a )anthracene-treated rats. (pnas.org)
  • An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive results. (medindia.net)
  • With its tumor-tracking capabilities and natural cancer-killing properties, experimental NSC-TRAIL combination may offer a new approach for treating gliomas. (innovations-report.com)
  • In mouse and cell culture models of breast cancer, deficiency in vitamin D resulted in tumors that grew faster and were more likely to metastasize, according to a recent study. (oncologynurseadvisor.com)
  • Tumor autonomous effects of vitamin D deficiency promote breast cancer metastasis [published online ahead of print March 2, 2016]. (oncologynurseadvisor.com)
  • Many cancer treatments work by disrupting the formation of new blood vessels that feed growing tumors. (bio-medicine.org)
  • Phytochemicals are nutrients derived from plants, and they are healthy buzzwords in nutrition and cancer research. (abta.org)
  • Lippard and Steinmetz continue to collaborate, investigating use of this system to deliver other drugs or drug candidates, use in other types of cancers, the addition of agents on the exterior of the shell to increase accumulation inside tumors and more. (teknoscienze.com)
  • Identification of selected genetic changes, and the biological processes they regulate arising in primary MSC tumors, will advance individualizing therapy and improve the outcome of patients with rare cancers. (medindia.net)
  • SV40 is associated significantly with brain tumors, bone cancers, malignant mesothelioma, and non-Hodgkin's lymphoma. (greenmedinfo.com)
  • Likewise, ADAMs (A Disintegrin And Metalloproteases), including ADAM12, are upregulated in malignant tumors and contribute to the pathology of cancers. (biologists.org)
  • Here we show that moderate activation of the pathway conferred either by mutation in the Gα subunit or by mutation in the regulatory subunit of the protein kinase A influences tumor morphology. (apsnet.org)
  • L1 protein was detected in concentrated plant extracts at concentrations up to 1.0 mg/kg in transgenic plants and up to 0.4 mg/kg in TMV-infected plants. (asm.org)
  • In conclusion, our data suggest that a ternary protein complex composed of ADAM12, αVβ3 integrin, and MMP-14 at the tumor cell surface regulates MMP-14 functions. (biologists.org)
  • Patients with gross residual disease, positive findings on peritoneal cytology, and recurrent tumors were included. (medscape.com)
  • is inhibited by cell walls from normal dicotyledonous plants but not by cell walls from crown-gall tumors apparently because of bacterial adherence or nonadherence, respectively, to the different cell walls. (sciencemag.org)
  • Nanorods accumulate in the tumors, and within three days, the liver and spleen clear any that don't reach the tumor. (phys.org)
  • brown tumor a giant-cell granuloma produced in and replacing bone, occurring in osteitis fibrosa cystica and due to hyperparathyroidism. (thefreedictionary.com)
  • Cannabis Science has been working closely with this patient who has multiple squamous cell carcinoma tumors on his head. (theweedblog.com)
  • The tumors treated with NSC-TRAIL had also decreased significantly in size, compared with the controls. (innovations-report.com)
  • 0.01, 51 metabolites were significantly different between borderline tumors and carcinomas, with a false discovery rate of 7.8%, estimated with repeated permutation analysis. (aacrjournals.org)
  • Our study shows for the first time that large-scale metabolic profiling using GC-TOF MS is suitable for analysis of fresh frozen human tumor samples, and that there is a consistent and significant change in primary metabolism of ovarian tumors, which can be detected using multivariate statistical approaches. (aacrjournals.org)
  • Nanoparticles based on plant viruses are emerging biomaterials for medical applications such as drug delivery and imaging. (nih.gov)
  • The long, thin tobacco mosaic virus nanoparticles are naturals for delivering the drug candidate into tumors, said Steinmetz, who was appointed by the Case Western Reserve School of Medicine. (teknoscienze.com)