Trypanosoma brucei gambiense: A hemoflagellate subspecies of parasitic protozoa that causes Gambian or West African sleeping sickness in humans. The vector host is usually the tsetse fly (Glossina).Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.Trypanosoma brucei brucei: A hemoflagellate subspecies of parasitic protozoa that causes nagana in domestic and game animals in Africa. It apparently does not infect humans. It is transmitted by bites of tsetse flies (Glossina).Trypanocidal Agents: Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.Trypanosoma brucei rhodesiense: A hemoflagellate subspecies of parasitic protozoa that causes Rhodesian sleeping sickness in humans. It is carried by Glossina pallidipes, G. morsitans and occasionally other species of game-attacking tsetse flies.Trypanosoma: A genus of flagellate protozoans found in the blood and lymph of vertebrates and invertebrates, both hosts being required to complete the life cycle.Trypanosomiasis: Infection with protozoa of the genus TRYPANOSOMA.Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.Guinea: A republic in western Africa, south of SENEGAL and MALI, east of GUINEA-BISSAU. Its capital is Conakry.Tsetse Flies: Bloodsucking flies of the genus Glossina, found primarily in equatorial Africa. Several species are intermediate hosts of trypanosomes.Variant Surface Glycoproteins, Trypanosoma: Glycoproteins attached to the surface coat of the trypanosome. Many of these glycoproteins show amino acid sequence diversity expressed as antigenic variations. This continuous development of antigenically distinct variants in the course of infection ensures that some trypanosomes always survive the development of immune response to propagate the infection.Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.Equatorial Guinea: A republic in central Africa, bordering the Bay of Biafra, CAMEROON is to the north and GABON to the south. Its capital is Malabo.Trypanosoma cruzi: The agent of South American trypanosomiasis or CHAGAS DISEASE. Its vertebrate hosts are man and various domestic and wild animals. Insects of several species are vectors.Cote d'Ivoire: A republic in western Africa, south of MALI and BURKINA FASO, bordered by GHANA on the east. Its administrative capital is Abidjan and Yamoussoukro has been the official capital since 1983. The country was formerly called Ivory Coast.Congo: A republic in central Africa lying between GABON and DEMOCRATIC REPUBLIC OF THE CONGO and south of Cameroon. Its capital is Brazzaville.Democratic Republic of the Congo: A republic in central Africa, east of the REPUBLIC OF THE CONGO, south of the CENTRAL AFRICAN REPUBLIC and north of ANGOLA and ZAMBIA. The capital is Kinshasa.Sudan: A country in northeastern Africa. The capital is Khartoum.Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.Parasitology: The study of parasites and PARASITIC DISEASES.DNA, Protozoan: Deoxyribonucleic acid that makes up the genetic material of protozoa.Cerebrospinal Fluid: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.Protozoan Proteins: Proteins found in any species of protozoan.Antibodies, Protozoan: Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.RNA, Protozoan: Ribonucleic acid in protozoa having regulatory and catalytic roles as well as involvement in protein synthesis.Trypanosoma congolense: A species of Trypanosome hemoflagellates that is carried by tsetse flies and causes severe anemia in cattle. These parasites are also found in horses, sheep, goats, and camels.Trypanosoma vivax: An active blood parasite that is present in practically all domestic animals in Africa, the West Indies, and parts of Central and South America. In Africa, the insect vector is the tsetse fly. In other countries, infection is by mechanical means indicating that the parasites have been introduced to these countries and have been able to maintain themselves in spite of the lack of a suitable intermediate host. It is a cause of nagana, the severity of which depends on the species affected.Genes, Protozoan: The functional hereditary units of protozoa.Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.DNA, Kinetoplast: DNA of kinetoplasts which are specialized MITOCHONDRIA of trypanosomes and related parasitic protozoa within the order KINETOPLASTIDA. Kinetoplast DNA consists of a complex network of numerous catenated rings of two classes; the first being a large number of small DNA duplex rings, called minicircles, approximately 2000 base pairs in length, and the second being several dozen much larger rings, called maxicircles, approximately 37 kb in length.Hemorrhagic Fevers, Viral: A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.Hemorrhagic Fever, Ebola: A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Semen: The thick, yellowish-white, viscid fluid secretion of male reproductive organs discharged upon ejaculation. In addition to reproductive organ secretions, it contains SPERMATOZOA and their nutrient plasma.Ebola Vaccines: Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.Marburg Virus Disease: An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.Ebolavirus: A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.Drugs, Essential: Drugs considered essential to meet the health needs of a population as well as to control drug costs.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Cost-Benefit Analysis: A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.Diagnostic Equipment: Nonexpendable items used in examination.World Health Organization: A specialized agency of the United Nations designed as a coordinating authority on international health work; its aim is to promote the attainment of the highest possible level of health by all peoples.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Public Sector: The area of a nation's economy that is tax-supported and under government control.Histoplasma: A mitosporic Onygenales fungal genus causing HISTOPLASMOSIS in humans and animals. Its single species is Histoplasma capsulatum which has two varieties: H. capsulatum var. capsulatum and H. capsulatum var. duboisii. Its teleomorph is AJELLOMYCES capsulatus.Naegleria fowleri: A species of parasitic protozoa having both an ameboid and flagellate stage in its life cycle. Infection with this pathogen produces PRIMARY AMEBIC MENINGOENCEPHALITIS.Blastomyces: A genus of onygenacetous mitosporic fungi whose perfect state is Ajellomyces (see ONYGENALES). The species Blastomyces dermatitidis (perfect state Ajellomyces dermatitidis) causes blastomycosis.Histoplasmosis: Infection resulting from inhalation or ingestion of spores of the fungus of the genus HISTOPLASMA, species H. capsulatum. It is worldwide in distribution and particularly common in the midwestern United States. (From Dorland, 27th ed)Coccidioides: A mitosporic fungal genus which causes COCCIDIOIDOMYCOSIS.Naegleria: A free-living soil amoeba pathogenic to humans and animals. It occurs also in water and sewage. The most commonly found species in man is NAEGLERIA FOWLERI which is the pathogen for primary amebic meningoencephalitis in primates.
2005). "Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African ... December 2006). "Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical ... Pepin J, Milord F, Guern C, Schechter PJ (1987). "Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense ... Trypanosoma brucei gambiense). In the 1980s, Gillette was awarded a patent for the discovery that topical application of ...
"Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense (African Trypanosomiasis) - Infectious Disease and ... For Trypanosoma brucei gambiense, the medication eflornithine is usually preferred. It is given by injection into a vein. ... It is specifically used for second-stage disease caused by Trypanosoma brucei rhodesiense when the central nervous system is ... Treatment is based on stage, 1 or 2, and parasite,T. b. rhodesiense or T. b. gambiense. In stage 1 disease, trypanosomes are ...
To be used for the treatment of Trypanosoma brucei gambiense infection. To be used for the treatment of the initial phase of ... Trypanosoma brucei rhodesiense infection. To be used for the treatment of Trypanosoma brucei gambiense infection Only to be ... used in combination with eflornithine, for the treatment of T. b. gambiense infection. Deferasirox oral form may be an ...
This was first observed in rats infected by Trypanosoma brucei gambiense. and correlation with protein intake has been ... Tryptophan in Rats Infected with Trypanosoma brucei gambiense". J Infect Dis. 131 (4): 459-462. doi:10.1093/infdis/131.4.459. ...
It is formed from tryptophan, along with indole-3-acetic acid in rats infected by Trypanosoma brucei gambiense. An efficient ... Tryptophan in Rats Infected with Trypanosoma brucei gambiense". Journal of Infectious Diseases. 131 (4): 459-62. doi:10.1093/ ... It is produced by the trypanosomal parasite (Trypanosoma brucei) in sleeping sickness (African trypanosomiasis). It is found in ...
Stibbs HH, Seed JR (Apr 1975). "Short-term metabolism of (14-C) tryptophan in rats infected with Trypanosoma brucei gambiense ...
There are two known subspecies that infect humans, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense. Eradication ... Also, Trypanosoma brucei has a direct inhibitory effect upon B cells. One strategy may involve a vaccine against the initial ... May 2002). "Congopain from Trypanosoma congolense: drug target and vaccine candidate". Biol. Chem. 383 (5): 739-49. PMID ... "Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: targeting the disease rather than the parasite". ...
Trypanosoma brucei gambiense causes the diseases in west and central Africa, whereas Trypanosoma brucei rhodesiense has a ... There are two types that infect humans, Trypanosoma brucei gambiense (TbG) and Trypanosoma brucei rhodesiense (TbR). TbG causes ... human for Trypanosoma brucei gambiense, and animals for Trypanosoma brucei rhodesiense). The risk of contracting African ... 2002). "Evaluation of the micro-CATT, CATT/Trypanosoma brucei gambiense, and LATEX/T b gambiense methods for serodiagnosis and ...
July 2009). "Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis ... Melarsoprol and Nifurtimox Monotherapy and Combination Therapy for the Treatment of Second-Stage Trypanosoma brucei gambiense ... 1989). "An open clinical trial of nifurtimox for arseno-resistant T. b. gambiense sleeping sickness in central Zaire". Trans R ... Estani, Sergio Sosa; Segura, Elsa Leonor (1999-09-01). "Treatment of Trypanosoma cruzi infection in the undetermined phase. ...
... which is caused by either Trypanosoma brucei gambiense or Trypanosoma brucei rhodesiense. Chagas disease causes 21,000 deaths ... 2007). "Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host ... is the name of several diseases in vertebrates caused by parasitic protozoan trypanosomes of the genus Trypanosoma.[citation ...
The studies were performed by infecting laboratory animals such as mice, dogs and monkeys with Trypanosoma brucei gambiense and ...
200mm³ Treatment of leishmaniasis Treatment of African trypanosomiasis caused by Trypanosoma brucei gambiense Pentamidine is ... Strains of the Trypanosoma brucei parasite that are resistant to pentamidine have been discovered. Pentamidine is brought into ... Pentamidine binds to adenine-thymine-rich regions of the Trypanosoma parasite DNA, forming a cross-link between two adenines ... Similarly, pentamidine inhibits type II topoisomerase in the mitochondria of the Trypanosoma parasite, resulting in breaks and ...
For example, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense are both devastating human parasites, but the ... related subspecies Trypanosoma brucei brucei will infect a number of animal hosts, but cannot even survive in the human blood ... So a related (or unidentifiable) species of Trypanosoma found in a paleontological or archaeological context may not be a true ...
... trypanosoma brucei brucei MeSH B01.500.841.750.443.950.450.868.887.110 --- trypanosoma brucei gambiense MeSH B01.500.841.750. ... trypanosoma brucei rhodesiense MeSH B01.500.841.750.443.950.450.868.887.128 --- trypanosoma congolense MeSH B01.500.841.750. ... 443.950.450.868.887.140 --- trypanosoma cruzi MeSH B01.500.841.750.443.950.450.868.887.410 --- trypanosoma lewisi MeSH B01.500. ... 841.750.443.950.450.868.887.850 --- trypanosoma vivax MeSH B01.500.841.750.443.950.725 --- trichomonadida MeSH B01.500.841.750. ...
... the treatment of Trypanosoma brucei gambiense infection To be used for the treatment of the initial phase of Trypanosoma brucei ... gambiense infection Deferasirox oral form may be an alternative, depending on cost and availability. Polygeline, injectable ... rhodesiense infection To be used for the treatment of T. b. gambiense infection Only to be used in combination with ...
Trypanosoma brucei gambiense and Trypansoma brucei rhodesiense) which cause African Trypanosomiasis (sleeping sickness). Ticks ...
... work on sleeping sickness and were the first to distinguish Trypanosoma brucei rhodesiense from Trypanosoma brucei gambiense ( ... brucei gambiense and T. brucei rhodesiense by the names T. gambiense and T. rhodesiense, respectively - contrary to ...
... a disease caused by the parasites Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense which is more commonly known ...
To be used for the treatment of Trypanosoma brucei gambiense infection *^ To be used for the treatment of the initial phase of ... For the treatment of 1st and 2nd stage human African trypanosomiasis due to Trypanosoma brucei gambiense infection ... To be used for the treatment of T. b. gambiense infection *^ Only to be used in combination with eflornithine, for the ... treatment of T. b. gambiense infection *^ Certolizumab pegol, etanercept, golimumab and infliximab are alternatives, including ...
... gambiense is found in Central and West Africa. Trypanosoma brucei gambiense evolved from a single progenitor ~10,000 years ago ... T. brucei brucei - Causes animal trypanosomiasis, along with several other species of Trypanosoma. T. b. brucei is not ... Trypanosoma brucei gambiense causes 97% of human cases of sleeping sickness. Resistance to ApoL1 is principally mediated by the ... T. brucei has traditionally been grouped into three subspecies: T. b. brucei, T. b. gambiense and T. b. rhodesiense. The first ...
... brucei, T. rhodesiense and T. gambiense". Veterinary Pathology. 9 (1 Suppl): 1-79. doi:10.1177/030098587200901s01. ISSN 0300- ... Trypanosoma congolense is a species of trypanosomes and is the major pathogen responsible for the disease nagana in cattle and ... Losos, G. J.; Ikede, B. O. (1972). "Review of pathology of diseases in domestic and laboratory animals caused by Trypanosoma ... In its mammalian host, Trypanosoma congolense only lives in blood vessels, and causes in particular anaemia. Deschamps, Jack- ...
Trypanosoma brucei gambiense was thought to have a slower onset and Trypanosoma brucei rhodesiense refers to strains with a ... The trypanosomes infectious to animals and not to humans were named Trypanosoma brucei brucei. Strains that infected humans ... The species Trypanosoma brucei, which causes the disease, has often been subdivided into three subspecies that were identified ... Trypanosoma congolense and Trypanosoma vivax are the two most important species infecting bovine cattle in sub-Saharan Africa. ...
Od triptofana, formiraju ga , uz indol-3-sirćetnu kiselinu i pacovi koji su inficirani protozoom Trypanosoma brucei gambiense ... Stibbs, H. H.; Seed, J. R. (1975). "Short-Term Metabolism of \14C]Tryptophan in Rats Infected with Trypanosoma brucei gambiense ... Trypanosoma brucei), koja izaziva bolest spavanja (afrička tripanozomijaza).[1][4] ...
Trypanosoma brucei gambiense was thought to have a slower onset and Trypanosoma brucei rhodesiense refers to strains with a ... Trypanosoma agents. Distribution. Glossina vectors. Sleeping sickness - chronic form. humans. T. brucei gambiense. Western ... The trypanosomes infectious to animals and not to humans were named Trypanosoma brucei brucei. Strains that infected humans ... T. brucei brucei. Africa. G. morsitans. G. swynnertoni. G. pallidipes. G. palpalis. G. tachinoides. G. fuscipes. ...
To be used for the treatment of Trypanosoma brucei gambiense infection. *↑ To be used for the treatment of the initial phase of ... To be used for the treatment of Trypanosoma brucei gambiense infection. *↑ Only to be used in combination with eflornithine, ... for the treatment of Trypanosoma brucei gambiense infection. *↑ Deferasirox oral form may be an alternative, depending on cost ...
Trypanosoma brucei (Kinetoplastida) Mušica Glossina Chagova boleat (Američka bolest spavanja) Trypanosoma cruzi (Kinetoplastida ... Ili su paraziti( na beskičmenjacima i na kičmenjacima). Među čovjekovim parazitima su: tryponosoma gambiense i tryponosoma ... "Trypanosoma brucei". parasite.org.au. Pristupljeno 23. 3. 2018.. *^ "Microscopy of Entamoeba histolytica". msu.edu. ...
Trypanosoma brucei + * Trypanosoma brucei gambiense * Trypanosoma brucei gambiense DAL972 * Trypanosoma brucei gambiense group ... Trypanosoma brucei rhodesiense Trusted • Trypanosoma brucei gambiense Trusted • Trypanosoma brucei brucei Trusted ... more ... Trypanosoma brucei Trusted • Trypanosoma brucei rhodesiense Trusted • Trypanosoma brucei gambiense Trusted ... more taxon ... Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense are protozoan parasites that are the cause of nearly all human ...
... of molecular diversity within the Trypanosoma brucei subspecies Trypanosoma brucei brucei and Trypanosoma brucei gambiense as ... Phospholipase A2 from Trypanosoma brucei gambiense and Trypanosoma brucei brucei: inhibition by organotins. M N Shuaibu. ... Differential effects of Trypanosoma brucei gambiense and Trypanosoma brucei brucei on rat macrophages. Kazuhiko Nishimura. ... from Trypanosoma brucei gambiense (Wellcome strain) and Trypanosoma brucei brucei (GUTat 3.1) were examined using two different ...
Trypanosoma brucei gambiense lacks the SRA gene, yet it infects humans. As transfection of T. b. gambiense (group 1) is not ... Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor.. [Rudo Kieft, Paul Capewell, ... Human innate immunity against most African trypanosomes, including Trypanosoma brucei brucei, is mediated by a minor subclass ... Trypanosoma brucei rhodesiense causes human African sleeping sickness because it has evolved an inhibitor of TLF-1, serum ...
Trypanosoma brucei brucei. Trypanosoma brucei. Trypanosoma brucei brucei (strain 927/4 GUTat10.1). Trypanosoma brucei gambiense ... Trypanosoma brucei brucei. Trypanosoma brucei. Trypanosoma brucei brucei (strain 927/4 GUTat10.1). Trypanosoma brucei gambiense ... Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)Imported. ,p>Information which has been imported from another database ... tr,C9ZHU8,C9ZHU8_TRYB9 Phosphoglycerate kinase OS=Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) OX=679716 GN=TbgDal_ ...
A number of new tools will fill critical gaps in the current armamentarium for diagnosing and treating Gambiense HAT. Deploying ... Contemporary and emerging strategies for eliminating human African trypanosomiasis due to Trypanosoma brucei gambiense: review ... Keywords: Gambiense HAT; TAH Gambiense; THA gambiense; control; contrôle; eliminación; elimination; escenarios; estrategias; ... Conclusions: A number of new tools will fill critical gaps in the current armamentarium for diagnosing and treating Gambiense ...
... brucei brucei, T. brucei gambiense, and T. brucei rhodesiense, respectively. Both T. b. brucei and T. b. rhodesiense probes ... brucei gambiense group I. No other stock hybridized with this amplified fragment. Since the T. b. gambiense probe obtained is ... brucei classic subspecies. The kinetoplast DNA minicircle variable regions from these stocks have been amplified using the ... hybridized only with their own stocks, but the T. b. gambiense probe specifically hybridized with a group of 12 stocks that ...
... infection and Trypanosoma brucei gambiense sleeping sickness, all incident cases of trypanosomiasis and a control group of ... brucei gambiense sleeping sickness in rural Zaire, but the possibility that incident cases of trypanosomiasis concurrently ... The Impact of Human Immunodeficiency Virus Infection on the Epidemiology and Treatment of Trypanosoma Brucei Gambiense Sleeping ... infection and Trypanosoma brucei gambiense sleeping sickness, all incident cases of trypanosomiasis and a control group of ...
... J Cnops, F Kauffmann, C De Trez, T Baltz, ... Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing ... Trypanosoma brucei gambiense accounts for 98\% of the reported HAT infections and causes a chronic, gradually progressing ... 2016). Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection. PARASITE IMMUNOLOGY, 38(10), 642- ...
Persistence of antibodies to Trypanosoma brucei gambiense after treatment of human trypanosomiasis in Uganda. - C Paquet, T ... Persistence of antibodies to Trypanosoma brucei gambiense after treatment of human trypanosomiasis in Uganda.. Authors. C ...
Most cases are caused by infection with Trypanosoma brucei gambiense. Diagnosis of HAT relies on the identification of ... Most cases are caused by infection with Trypanosoma brucei gambiense. Diagnosis of HAT relies on the identification of ... Rooney B, Piening T, Buscher P, Roge S, Smales CM (2015) Expression of Trypanosoma brucei gambiense Antigens in Leishmania ... 1992) Absence of the LiTat 1.3 (CATT antigen) gene in Trypanosoma brucei gambiense stocks from Cameroon. Acta Trop 51: 123-134 ...
Neopterin Is a Cerebrospinal Fluid Marker for Treatment Outcome Evaluation in Patients Affected by Trypanosoma brucei gambiense ... Neopterin Is a Cerebrospinal Fluid Marker for Treatment Outcome Evaluation in Patients Affected by Trypanosoma brucei gambiense ... Neopterin Is a Cerebrospinal Fluid Marker for Treatment Outcome Evaluation in Patients Affected by Trypanosoma brucei gambiense ... Here we show that neopterin, already proven to be a powerful marker for staging T. b. gambiense HAT, is also useful in ...
... caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options for patients with second-stage disease are ... Three Drug Combinations for Late-Stage Trypanosoma brucei gambiense Sleeping Sickness: A Randomized Clinical Trial in Uganda. * ... Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study. ... Background Human African trypanosomiasis (HAT; sleeping sickness) caused by Trypanosoma brucei gambiense is a fatal disease. ...
Digital gene expression analysis of two life cycle stages of the human-infective parasite, Trypanosoma brucei gambiense reveals ... To investigate this in the clinically relevant sub-species, Trypanosoma brucei gambiense, which is the causative agent of the ... Trypanosoma brucei gambiense reveals differentially expressed clusters of co-regulated genes. BMC Medical Genomics, 11, p. 124 ... Trypanosoma brucei gambiense reveals differentially expressed clusters of co-regulated genes. BMC Medical Genomics, 11, p. 124 ...
Background Human African trypanosomiasis (HAT; sleeping sickness) caused by Trypanosoma brucei gambiense is a fatal disease. ... Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a ... Patients aged 15 years or older with confirmed second-stage T b gambiense infection were randomly assigned by computer- ...
However, a number of individuals exposed to Trypanosoma brucei gambiense are able to control infection to undetectable levels ... production in whole blood stimulation assays is associated with latent Trypanosoma brucei gambiense infections. ...
Trypanosoma congolense and Trypanosoma brucei. The T. b. gambiense partial shotgun project is being carried out in ... Trypanosoma brucei. Protozoan parasites within the species Trypanosoma brucei are the etiological agent of human sleeping ... The Trypanosoma brucei gambiense Partial Genome Project. The Wellcome Trust Sanger Institute Pathogen Genomics group has ... The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis.. Jackson AP, ...
... DSpace/Manakin Repository. ... Identification of peptide mimotopes of Trypanosoma brucei gambiense variant surface glycoproteins. Van Nieuwenhove, L. C.; Rogé ... Trypanosoma brucei gambiense. Vectors. Tsetse flies. Glossina morsitans morsitans. Diagnosis. Antibody detection. Variants. ... of Trypanosoma brucei (T.b.) gambiense. These native VSGs are difficult to produce, and contain non-specific epitopes that may ...
What is Trypanosoma hominis? Meaning of Trypanosoma hominis medical term. What does Trypanosoma hominis mean? ... Looking for online definition of Trypanosoma hominis in the Medical Dictionary? Trypanosoma hominis explanation free. ... Synonym(s): Trypanosoma gambiense, Trypanosoma hominis, Trypanosoma ugandense. Trypanosoma brucei gambiense. See Gambian ... Trypanosoma vivax (syn. Trypanosoma caprae, Trypanosoma angolense). *Trypanosoma vivax (syn. Trypanosoma caprae, Trypanosoma ...
Genetic characterization of Trypanosoma brucei gambiense and clinical evolution of human African trypanosomiasis in Cote ... Trypanosoma brucei gambiense group 1; T. b. bfl,Trypanosoma brucei bouafle group; T. b. rh, Trypanosoma brucei rhodesiense; T. ... Trypanosoma brucei gambiense group 1; T. b. bfl, Trypanosoma brucei bouafle group; T. congo, Trypanosomacongolense.References: ... b. b,Trypanosoma brucei brucei; T. congo., Trypanosoma congolense.* For PCR of microsatellites sequences, only Jua and Peya ...
2005). "Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African ... December 2006). "Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical ... Pepin J, Milord F, Guern C, Schechter PJ (1987). "Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense ... Trypanosoma brucei gambiense). In the 1980s, Gillette was awarded a patent for the discovery that topical application of ...
Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing ... Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing ... Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing ... Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing ...
"Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense (African Trypanosomiasis) - Infectious Disease and ... For Trypanosoma brucei gambiense, the medication eflornithine is usually preferred. It is given by injection into a vein. ... It is specifically used for second-stage disease caused by Trypanosoma brucei rhodesiense when the central nervous system is ... Treatment is based on stage, 1 or 2, and parasite,T. b. rhodesiense or T. b. gambiense. In stage 1 disease, trypanosomes are ...
The two Trypanosoma brucei subspecies that cause African trypanosomiasis, T. b. gambiense and T. b. rhodesiense, are ... Humans are considered the main reservoir for Trypanosoma brucei gambiense, but this species can also be found in animals, ... Figure A: Trypanosoma brucei ssp. in a thin blood smear stained with Giemsa. The trypomastigote is beginning to divide; ... Figure A: Trypanosoma brucei ssp. in a thin blood smear stained with Wright-Giemsa. ...
Trypanosoma brucei gambiense, Trypanosoma brucei rhodesiense. Tsetse flies. Babesiosis. Babesia microti and other species. ... Parasites, such as Trypanosoma cruzi, might be found in the blood early in an infection (the acute phase) and then at much ... Currently, most of the U.S. blood supply is screened for Trypanosoma cruzi (the parasite that causes Chagas disease). If the ...
Prospective evaluation of a rapid diagnostic test for Trypanosoma brucei gambiense infection developed using recombinant ... Diagnosis and treatment are central elements of strategies to control Trypanosoma brucei gambiense human African ... Prospective evaluation of a rapid diagnostic test for Trypanosoma brucei gambiense infection developed using recombinant ... Prospective evaluation of a rapid diagnostic test for Trypanosoma brucei gambiense infection developed using recombinant ...
  • The primary focus of Dr. Kolev's research is the molecular mechanism governing the development of the protozoan parasite Trypanosoma brucei to its infectious metacyclic form, responsible for the transmission of African sleeping sickness and related diseases from the tsetse fly vector to the mammalian host. (yale.edu)
  • Trypanosoma brucei multiply as infective bloodstream (BS) forms in the blood and body fluids of their mammalian hosts and as procyclic insect form in the midgut of the tsetse fly vector. (prolekare.cz)
  • The tsetse fly vector is of interest for its potential to prevent disease spread, as it is essential for T. brucei life cycle progression and transmission. (asm.org)
  • T. brucei possesses a two-unit genome, a nuclear genome and a mitochondrial (kinetoplast) genome with a total estimated size of 35Mb/haploid genome. (sanger.ac.uk)
  • Beowulf Genomics funded a pilot scheme to sequence chromosome Ia of T. brucei as a collaboration with Professor Keith Gull (University of Oxford) and Dr. Sara Melville (University of Cambridge) within the framework of the World Health Organisation T. brucei Genome Project. (sanger.ac.uk)
  • In April 2000, the Wellcome Trust, via its Beowulf Genomics Initiative, awarded more funding to the T.brucei genome project at the Sanger Institute to sequence chromosomes IX (3.5 Mb), X (4.4 Mb) and XI (5.2 Mb) in collaboration with Dr. Sara Melville and the WHO/TDR supported T. brucei Genome Network. (sanger.ac.uk)
  • Annotation and curation of the whole T. brucei genome sequence is ongoing. (sanger.ac.uk)
  • Pulsed-field gel electrophoresis of whole chromosome-sized DNAs from the genome of T. brucei strain 927 resolves 2 "intermediate-sized" bands of ~350kb, representing 2, or possibly 4, intermediate chromosomes. (sanger.ac.uk)
  • In this study we have examined, by whole-genome microarray analysis, the mRNA abundance of genes in slender and stumpy forms of T.brucei AnTat1.1 cells, and also during their synchronous differentiation to procyclic forms. (biomedcentral.com)
  • The Pathogen Genomics group in collaboration with Drs Gloria Rudenko (University of Oxford) and Ed Louis (University of Nottingham) has initiated the sequencing of VSG expression site containing telomeres of two T. brucei strains. (sanger.ac.uk)
  • The intermediate chromosomes of T. brucei strain 427 are known to encode bloodstream expression sites, 3 of which have been sequenced. (sanger.ac.uk)
  • Consistent with this view, the analogs were as effective against a T. b. brucei strain lacking the P2 nucleoside transporter as they were against the parental strain. (asm.org)
  • Compared to microarray analysis of the related T. b. brucei parasite, approximately 10 times more genes with a 2.5-fold change in expression levels were detected. (gla.ac.uk)
  • Bloodstream Trypanosoma brucei in which the genes for cytosolic lipid hydroperoxide-detoxifying peroxidases have been knocked out undergo an extremely rapid membrane peroxidation and lyse within less than two hours when they are cultured without an exogenous antioxidant. (prolekare.cz)
  • The kinetoplast DNA minicircle variable regions from these stocks have been amplified using the polymerase chain reaction (PCR) technique, and hybridized with the amplified variable regions of three T. brucei reference stocks, previously identified as T. brucei brucei, T. brucei gambiense , and T. brucei rhodesiense , respectively. (ajtmh.org)
  • Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense," American Journal of Tropical Medicine and Hygiene , vol. 67, no. 3, pp. 289-295, 2002. (hindawi.com)
  • METHODOLOGY/PRINCIPAL FINDINGS: PhD.-12 and PhD.-C7C phage display peptide libraries were screened with mouse monoclonal antibodies against the predominant VSGs LiTat 1.3 and LiTat 1.5 of T.b. gambiense. (itg.be)
  • a) Two morphological forms (long slender and short stumpy) of Trypanosoma brucei in a thin blood smear stained with Giemsa. (els.net)