Trypanocidal Agents: Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.Trypanosoma cruzi: The agent of South American trypanosomiasis or CHAGAS DISEASE. Its vertebrate hosts are man and various domestic and wild animals. Insects of several species are vectors.Trypanosoma brucei brucei: A hemoflagellate subspecies of parasitic protozoa that causes nagana in domestic and game animals in Africa. It apparently does not infect humans. It is transmitted by bites of tsetse flies (Glossina).Parasitic Sensitivity Tests: Tests that demonstrate the relative effectiveness of chemotherapeutic agents against specific parasites.Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.Diminazene: An effective trypanocidal agent.Trypanosoma brucei rhodesiense: A hemoflagellate subspecies of parasitic protozoa that causes Rhodesian sleeping sickness in humans. It is carried by Glossina pallidipes, G. morsitans and occasionally other species of game-attacking tsetse flies.Trypanosoma: A genus of flagellate protozoans found in the blood and lymph of vertebrates and invertebrates, both hosts being required to complete the life cycle.Benzamidines: Amidines substituted with a benzene group. Benzamidine and its derivatives are known as peptidase inhibitors.Trypanosomiasis: Infection with protozoa of the genus TRYPANOSOMA.Physalis: A plant genus of the family SOLANACEAE. Members contain physalin and withangulatin.Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.NitroimidazolesAmidinesPentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.Ruthenium Compounds: Inorganic compounds that contain ruthenium as an integral part of the molecule.Trypanosomiasis, Bovine: Infection in cattle caused by various species of trypanosomes.Inhibitory Concentration 50: The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.Garcinia: A plant genus of the family CLUSIACEAE. Members contain XANTHONES.Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.Mammea: A plant genus of the family CLUSIACEAE. Members contain xanthones and BENZOPHENONES. The common name of Mamey is also used with POUTERIA.Calophyllum: A plant genus of the family CLUSIACEAE. Members contain costatolide, calanolides and 4-phenylfuranocoumarins (FUROCOUMARINS).Trypanosoma congolense: A species of Trypanosome hemoflagellates that is carried by tsetse flies and causes severe anemia in cattle. These parasites are also found in horses, sheep, goats, and camels.Vitex: A genus of trees in the Lamiaceae family containing assorted flavonoids with possible analgesic and antineoplastic properties. The fruit of these trees is used in herbal preparations.Piper: A plant genus of the family PIPERACEAE that includes species used for spicy and stimulating qualities.Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.Antiprotozoal Agents: Substances that are destructive to protozoans.Robenidine: An anticoccidial agent mainly for poultry.NitrofuransAmbrosia: A plant genus of the family ASTERACEAE. The POLLEN is one cause of HAYFEVER.Eupatorium: A plant genus of the family ASTERACEAE. Ingestion has been associated with MILK SICKNESS. The common name of thoroughwort is also used for other plants including CHROMOLAENA; Hebeclinium, and Koanophyllon.Plant Components, Aerial: The above-ground plant without the roots.Plakortis: A genus of SPONGES in the family Plakinidae, with the skeleton formed by small diactine (and some triactine) needle-like terminations.Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.Mikania: A plant genus of the family ASTERACEAE. Members contain scandenolide (a sesquiterpene lactone) and germacranolides.Buffaloes: Ruminants of the family Bovidae consisting of Bubalus arnee and Syncerus caffer. This concept is differentiated from BISON, which refers to Bison bison and Bison bonasus.Rhamnaceae: The buckthorn plant family, of the order Rhamnales, includes some species with edible fruits and some that are medicinal.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Aristolochia: A plant genus of the family ARISTOLOCHIACEAE. Species of this genus have been used in traditional medicine but they contain aristolochic acid which is associated with nephropathy. These are sometimes called 'snakeroot' but that name is also used with a number of other plants such as POLYGALA; SANICULA; ASARUM; ARISTOLOCHIA; AGERATINA; and others.Lamiaceae: The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).Gentian Violet: A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.Laurus: A plant genus in the LAURACEAE family. Laurus nobilis L. leaves are known for use in SPICES, having a similar flavor as UMBELLULARIA.Nitroreductases: Enzymes which reduce nitro groups (NITRO COMPOUNDS) and other nitrogenous compounds.Chagas Cardiomyopathy: A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.Drug Evaluation, Preclinical: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.Leishmania mexicana: A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals including rodents. The Leishmania mexicana complex causes both cutaneous (LEISHMANIASIS, CUTANEOUS) and diffuse cutaneous leishmaniasis (LEISHMANIASIS, DIFFUSE CUTANEOUS) and includes the subspecies amazonensis, garnhami, mexicana, pifanoi, and venezuelensis. L. m. mexicana causes chiclero ulcer, a form of cutaneous leishmaniasis (LEISHMANIASIS, CUTANEOUS) in the New World. The sandfly, Lutzomyia, appears to be the vector.Blood Physiological Phenomena: Physiological processes and properties of the BLOOD.TriterpenesStructure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Lethal Dose 50: The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Parasitemia: The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)Protozoan Proteins: Proteins found in any species of protozoan.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
It is also a trypanocidal agent. When administered orally, it is metabolized to salicylamide which exerts analgesic, ...
... (melaminylthioarsenate) is a trypanocidal agent. In the U.S., it is marketed under the trade names Immiticide ( ...
A natural compound with trypanocidal activity". International Journal of Antimicrobial Agents. 37 (6): 536. doi:10.1016/j. ...
... is a trypanocidal agent for veterinary use. Hawking, F.; Sen, A. B. (1960). "The trypanocidal action of homidium ...
November 2002). "Ursolic acid as a trypanocidal constituent in rosemary". Biological & Pharmaceutical Bulletin. 25 (11): 1485-7 ...
Ulrich, P.; Cerami, A. (Jan 1984). "Trypanocidal 1,3-arylene diketone bis(guanylhydrazone)s. Structure-activity relationships ...
2007). "African Buffalo Serum Contains Novel Trypanocidal Protein". The Journal of Eukaryotic Microbiology. 41 (2): 95-103. doi ...
Ramos-Ligonio, Angel; López-Monteon, Aracely; Trigos, Ángel (2012-06-01). "Trypanocidal Activity of Ergosterol Peroxide from ... trypanocidal and antitumor activities in vitro. Lobo AM, Abreu PM, Prabhakar S, Godhino LS, Jones R, Rzepa HS, Williams DJ ( ...
I. Papanastasiou; A. Tsotinis; N. Kolocouris; S. R. Prathalingam; J. M. Kelly (2008). "Design, synthesis, and trypanocidal ...
Keiser J., Ericsson O, Burri C (2000). "Investigations of the metabolites of the trypanocidal drug melarsoprol". Clinical ...
... is a trypanocidal agent used in veterinary medicine. D. D. Whitelaw; I. R. Bell; P. H. Holmes; S. K. ...
Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH. Toxicon. Irazazabal, Luz N.; ...
2005). "The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes". J Parasitol. 91 ( ...
Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH. Toxicon. "Wasp study finds ...
These compounds displayed moderate antiplasmodial (against Plasmodium falciparum) and trypanocidal (against Trypanosoma cruzi) ...
Trypanocidal drug suramin is polysulfated and gives a positive alcian blue reaction even at pH 1. Thus, in tissues from a ...
... superba and Alchornea cordifolia showed trypanocidal activity (Adewunmi, 2001). The International Centre of Insect Physiology ...
"In vitro leishmanicidal and trypanocidal evaluation and magnetic properties of 7-amino-1,2,4-triazolo[1,5-a]pyrimidine Cu(II) ...
Eradication of infectious diseases#Human African Trypanosomiasis Trypanocidal agent "US Fraunhofer Center receives Grant from ...
Suresh S, Turley S, Opperdoes FR, Michels PA, Hol WG (May 2000). "A potential target enzyme for trypanocidal drugs revealed by ...
These parasites are usually attacked by ablastin, a trypanocidal IgG antibody produced by their host's immune system beginning ...
... new trypanocidal drugs and to establish the basis for the development of a vaccine for AAT. The Controlling AAT project was ... as a diagnostic test for field diagnosis of infection in cattle and to improve the quality control of existing trypanocidal ...
The removal of trypanosomosis will eliminate the need for constant prophylactic treatments of the cattle with trypanocidal ... such as trypanocidal drugs, impregnated treated targets (ITT), insecticide-treated cattle (ITC), aerial spraying (Sequential ... and keeping cattle is only feasible when the animals are kept under constant prophylactic treatment with trypanocidal drugs, ...
... trypanocidal agents MeSH D27.505.954.122.388 --- antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH ...
A trypanocidal agent is an antiprotozoal agent that acts upon trypanosome parasites. Examples include: Aminoquinuride ... Trypanocidal Agents at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of agents 82014344 GOBLE, ... F. C. (January 1950). "Chemotherapy of experimental trypanosomiasis; trypanocidal activity of certain bis (2-methyl-4-amino-6- ...
The Trypanocidal Activity of Naphthoquinones: A Review. Antônio Ventura Pinto 1 and Solange Lisboa de Castro 2,* ... Ventura Pinto, A.; Lisboa de Castro, S. The Trypanocidal Activity of Naphthoquinones: A Review. Molecules 2009, 14, 4570-4590. ... Ventura Pinto A, Lisboa de Castro S. The Trypanocidal Activity of Naphthoquinones: A Review. Molecules. 2009; 14(11):4570-4590 ... "The Trypanocidal Activity of Naphthoquinones: A Review." Molecules 14, no. 11: 4570-4590. ...
0/Reactive Oxygen Species; 0/Trypanocidal Agents; 96-26-4/Dihydroxyacetone; EC 2.7.1.-/Phosphotransferases (Alcohol Group ... we consider DHA a starting point for a rational design of new trypanocidal drugs.. ...
22] Saeidnia S, Gohari AR, Uchiyama N, Ito M, Honda G, Kiuchi F. Two new monoterpene glycosides and trypanocidal terpenoids ...
A trypanocidal agent is an antiprotozoal agent that acts upon trypanosome parasites. Examples include: Aminoquinuride ... Trypanocidal Agents at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of agents 82014344 GOBLE, ... F. C. (January 1950). "Chemotherapy of experimental trypanosomiasis; trypanocidal activity of certain bis (2-methyl-4-amino-6- ...
Clinical and veterinary trypanocidal benzoxaboroles target CPSF3. Richard J. Wall, Eva Rico, Iva Lukac, Fabio Zuccotto, Sara ... Clinical and veterinary trypanocidal benzoxaboroles target CPSF3. Richard J. Wall, Eva Rico, Iva Lukac, Fabio Zuccotto, Sara ... Clinical and veterinary trypanocidal benzoxaboroles target CPSF3. Richard J. Wall, Eva Rico, Iva Lukac, Fabio Zuccotto, Sara ... as an important drug target in trypanosomes and reveal inhibition of mRNA maturation as the mode of action of the trypanocidal ...
Trypanosoma cruzi: cytokine effects on macrophage trypanocidal activity.. Golden JM1, Tarleton RL. ...
The trypanocidal agents nifurtimox and benznidazole both function as prodrugs and must undergo enzyme-mediated activation, a ... trypanocidal agents. Summary. Summary: Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA. ... Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi. ... Trypanocidal drugs: mechanisms, resistance and new targets. Shane R Wilkinson. Queen Mary Pre Clinical Drug Discovery Group, ...
From this perspective, the aim of this work is to present new nitro analogs of megazol with trypanocidal activity designed ... B. Enanga, M. R. Ariyanayagam, M. L. Stewart, and M. P. Barrett, "Activity of megazol, a trypanocidal nitroimidazole, is ... N. Boechat, A. S. Carvalho, E. Fernandez-Ferreira et al., "Novel nitroimidazoles with trypanocidal and cell growth inhibition ... Evaluation of Genotoxic Effects of New Molecules with Possible Trypanocidal Activity for Chagas Disease Treatment. Francisco V ...
Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) ... Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) ... "Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) ... Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) ...
Trypanocidal Studies The trypanocidal activity over a 72 h period was determined using the Alamar Blue viability, as described ... A Class of 5-Nitro-2-furancarboxylamides with Potent Trypanocidal Activity against [genus-species: Trypanosoma brucei] in Vitro ... These findings imply that these two nitrofuran compounds, nifurtimox and 22s, are trypanocidal as a result of primarily ... Bot C.,; Hall B. S.,; Bashir N.,; Taylor M. C.,; Helsby N. A.,; Wilkinson S. R.,Trypanocidal activity of aziridinyl ...
Determination of trypanocidal activity of test samples. Compounds were tested for their activity against bloodstream forms of T ... Loiseau PM, Lubert P, Wolf JG (2000) Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of ... Antileishmanial and Trypanocidal Activities of Extracts and Aporphine Alkaloids Isolated from Monodora Genus (Annonaceae) Joël ... Antileishmanial; Trypanocidal; Monodora; Leishmania donovani; Trypanosoma brucei brucei; Aporphine alkaloids. Introduction. ...
Additionally, the biological activities of βLAP, NβL, ICβLAP, and ICNβL were investigated through trypanocidal assays with T. ... biological evaluation of β-lapachone and nor-β-lapachone complexes with 2-hydroxypropyl-β-cyclodextrin as trypanocidal agents." ... and biological evaluation of β-lapachone and nor-β-lapachone complexes with 2-hydroxypropyl-β-cyclodextrin as trypanocidal ... and biological evaluation of β-lapachone and nor-β-lapachone complexes with 2-hydroxypropyl-β-cyclodextrin as trypanocidal ...
A Preliminary Trypanocidal Study of Natural and Synthetic Supplementation of Zinc and Magnesium in Combination with Diminazene ... A Preliminary Trypanocidal Study of Natural and Synthetic Supplementation of Zinc and Magnesium in Combination with Diminazene ... Eighty healthy Wistar albino rats were used to investigate the trypanocidal effect of natural and synthetic supplements of zinc ... credence to the fact that the supplements of Zn2+ and Mg2+ with the subtherapeutic dose of 1.75 mg/kg had a better trypanocidal ...
AMBROZIN, Alessandra R. P. et al. New Pyrone and Quinoline Alkaloid from Almeidea rubra and their Trypanocidal Activity. J. Mex ... Keywords : Almeidea rubra; Rutaceae; alkaloids; trypanocidal activity. · abstract in Portuguese · text in English · English ( ... Additionally, these compounds were assayed on the tripomastigote forms of Trypanosoma cruzi showing moderate trypanocidal ...
The in vitro and in vivo trypanocidal activities of nine flavonoids (1-9) isolated from the aerial parts of Delphinium ... In vitro and in vivo trypanocidal activity of flavonoids from Delphinium staphisagria against Chagas disease. ... In vitro and in vivo trypanocidal activity of flavonoids from Delphinium staphisagria against Chagas disease. Journal of ...
TRYPANOCIDAL DRUGS. The use of trypanocidal drugs is the most widely accepted means of controlling the disease. However, the ... the use of trypanocidal drugs and, in some cases, * the promotion of trypanotolerant livestock; ... Furthermore, unless the tsetse fly is eradicated, insecticides and trypanocidal drugs must be used continuously in an effort to ... According to Jordan (1986), the overall prospects for the use of trypanocidal drugs against African animal trypanosomiasis (AAT ...
Nitrofurazone is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem. Nitrofurazone is also indicated in skin grafting when bacterial contamination may cause graft rejection or donor site infection, especially in hospitals with a history of resistant bacteria ...
Trypanocidal assay. Compounds cross-validated with low EC50 against T. cruzi infected cells were further evaluated to determine ... The top hit inhibited T. cruzi with EC50 of 17 nM and was trypanocidal at 40 nM. ... 2010) A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal ... Trypanocidal concentration of Compound 1 was 40 nM in three independent experiments, which compares favorably to posaconazole ( ...
The trypanocidal activity of bortezomib was determined with T. brucei bloodstream forms 427-221a while the general cytotoxicity ... 2). Thus, the trypanocidal activity of bortezomib was similar to melarsoprol with respect to the GI50 value and was 10 times ... 2). As a result, the GI50 and MIC ratios of cytotoxic/trypanocidal activities (selectivity indices) for bortezomib were less ... To check whether the trypanocidal activity of bortezomib is due to inhibition of the proteasome, the activity of this multi- ...
J Ethnopharmacol. 2018 Jan 10;210:311-317. doi: 10.1016/j.jep.2017.08.042. Epub 2017 Sep 5. Souza RODS1, Sousa PL2, Menezes RRPPB3, Sampaio TL3, Tessarolo LD2, Silva FCO4, Pereira MG4, Martins AMC5. Author information 1 Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil. Electronic address: [email protected] 2 Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil. 3 Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil. 4 Faculdade de Educação, Ciências e Letras do Sertão Central, Universidade Estadual do Ceará, Quixadá, Ceará, Brasil. 5 Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil. Electronic address: [email protected] Abstract ETHNOPHARMACOLOGICAL RELEVANCE: The parts of the Genipa americana (Rubiaceae) tree, also known as "jenipapo" or ...
1948). A.: An in vitro assay for trypanocidal activity. * (1943). Die neueren biochemischen Erkenntnisse und Probleme der ... Relation of Amino Acids to Trypanocidal Activity of Parasorbic Acid * By B. A. Rubin ...
Curcumin has trypanocidal properties.Jun 01, 1998. Click here to read the entire abstract. ...
The 4 compounds were trypanocidal in vitro. However, none of the compounds showed trypanocidal activity in vivo. Snapshot ... All were trypanocidal in vitro. [. 4. ]. . We tested four of these compounds for their trypanocidal efficacy in a mouse model ... All were trypanocidal in vitro. . We tested four of these compounds for their trypanocidal efficacy in a mouse model of ... The 4 compounds were trypanocidal in vitro. However, none of the compounds showed trypanocidal activity in vivo. Snapshot ...
  • These facts suggest that trypanocidal therapy may positively impact the clinical course of patients with chronic Chagas heart disease. (fiocruz.br)
  • The pilot study investigates whether etiologic treatment significantly reduces parasite burden, as assessed by polymerase chain reaction-based techniques and also determines the safety and tolerability profile of the trypanocidal drug in this type of chagasic population. (fiocruz.br)
  • We developed a paratransgenic approach where we exploit the commensal gut flora to express in the midgut mileu trypanocidal products that can block parasite development. (yale.edu)
  • The top hit inhibited T. cruzi with EC 50 of 17 nM and was trypanocidal at 40 nM. (plos.org)
  • 1948). The trypanocidal effect of antibiotic lactones and of their analogs. (core.ac.uk)
  • Khaya senegalensis, Piliostigma reticulatum , Securidaca longepedunculata, Ximenia americana and Artemisia abyssinica [ 2 , 13 , 14 ] and are strongly trypanocidal to T. b. brucei and T. congolense . (biomedcentral.com)
  • during her trypanocidal course for treatment side effects. (cdc.gov)
  • Aqueous extract of Acalypha hispida leaves suggest trypanocidal effect. (stuartxchange.com)
  • In these assays, the crude extract was more effective than the isolated clerodanes DCTN or CTN on trypomastigote while the trypanocidal effect of the triterpene AAA was against epimastigotes as well as on intracellular amastigotes (Campos et al. (thefreelibrary.com)
  • Many attempts have been done to find an appropriate drug which showed both a highly trypanocidal action and low or null toxicity for the host. (scielo.br)