AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Troponin TTroponinTroponin CTropomyosinMyocardiumBiological MarkersCreatine KinaseTroponin ICreatine Kinase, MB FormMyofibrilsChest PainMusclesMyocardial InfarctionRabbitsCalciumCardiomyopathy, HypertrophicAngina, UnstableActin CytoskeletonSarcomeresMuscle ProteinsActomyosinCardiomyopathy, Hypertrophic, FamilialMyosinsHeart InjuriesMyoglobinChickensCa(2+) Mg(2+)-ATPaseElectrocardiographyMyocardial ContractionNatriuretic Peptide, BrainPeptide FragmentsMuscle, SkeletalPredictive Value of TestsMyocardial IschemiaSensitivity and SpecificityHeartPrognosisProspective StudiesActinsElectrophoresis, Polyacrylamide GelCardiomyopathy, RestrictiveAmino Acid SequenceProtein IsoformsTime FactorsCardiomyopathiesIsoenzymesThiadiazinesAcute Coronary SyndromeNaphthalenesulfonatesMuscle ContractionAcute DiseaseCardiomyopathy, DilatedImmunoassayCardiac MyosinsPectinidaeMolecular Sequence DataHeart DiseasesChymotrypsinMyosin Heavy ChainsROC CurveMutationMyosin SubfragmentsMyocytes, CardiacAdenosine Triphosphatases
Troponin T
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
Troponin
One of the minor protein components of skeletal muscle. Its function is to serve as the calcium-binding component in the troponin-tropomyosin B-actin-myosin complex by conferring calcium sensitivity to the cross-linked actin and myosin filaments.
Troponin C
One of the three polypeptide chains that make up the TROPONIN complex of skeletal muscle. It is a calcium-binding protein.
Tropomyosin
A protein found in the thin filaments of muscle fibers. It inhibits contraction of the muscle unless its position is modified by TROPONIN.
Myocardium
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Creatine Kinase
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Troponin I
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
Creatine Kinase, MB Form
An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.
Myofibrils
The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES .
Chest Pain
Pressure, burning, or numbness in the chest.
Muscles
Contractile tissue that produces movement in animals.
Myocardial Infarction
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Rabbits
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Cardiomyopathy, Hypertrophic
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
Angina, Unstable
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Actin Cytoskeleton
Fibers composed of MICROFILAMENT PROTEINS, which are predominately ACTIN. They are the smallest of the cytoskeletal filaments.
Sarcomeres
The repeating contractile units of the MYOFIBRIL, delimited by Z bands along its length.
Muscle Proteins
The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.
Actomyosin
A protein complex of actin and MYOSINS occurring in muscle. It is the essential contractile substance of muscle.
Cardiomyopathy, Hypertrophic, Familial
An autosomal dominant inherited form of HYPERTROPHIC CARDIOMYOPATHY. It results from any of more than 50 mutations involving genes encoding contractile proteins such as VENTRICULAR MYOSINS; cardiac TROPONIN T; ALPHA-TROPOMYOSIN.
Myosins
A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.
Heart Injuries
General or unspecified injuries to the heart.
Myoglobin
A conjugated protein which is the oxygen-transporting pigment of muscle. It is made up of one globin polypeptide chain and one heme group.
Chickens
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
Ca(2+) Mg(2+)-ATPase
Electrocardiography
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Myocardial Contraction
Contractile activity of the MYOCARDIUM.
Natriuretic Peptide, Brain
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
Peptide Fragments
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Muscle, Skeletal
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Myocardial Ischemia
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Heart
The hollow, muscular organ that maintains the circulation of the blood.
Prognosis
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Prospective Studies
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Actins
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Electrophoresis, Polyacrylamide Gel
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Cardiomyopathy, Restrictive
A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Protein Isoforms
Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Cardiomyopathies
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
Isoenzymes
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Thiadiazines
Acute Coronary Syndrome
An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.
Naphthalenesulfonates
A class of organic compounds that contains a naphthalene moiety linked to a sulfonic acid salt or ester.
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Acute Disease
Disease having a short and relatively severe course.
Cardiomyopathy, Dilated
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
Immunoassay
A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.
Cardiac Myosins
Myosin type II isoforms found in cardiac muscle.
Pectinidae
A large family of mollusks in the class BIVALVIA, known commonly as scallops. They possess flat, almost circular shells and are found in all seas from shallow water to great depths.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Heart Diseases
Pathological conditions involving the HEART including its structural and functional abnormalities.
Chymotrypsin
A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.
Myosin Heavy Chains
The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.
ROC Curve
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Myosin Subfragments
Parts of the myosin molecule resulting from cleavage by proteolytic enzymes (PAPAIN; TRYPSIN; or CHYMOTRYPSIN) at well-localized regions. Study of these isolated fragments helps to delineate the functional roles of different parts of myosin. Two of the most common subfragments are myosin S-1 and myosin S-2. S-1 contains the heads of the heavy chains plus the light chains and S-2 contains part of the double-stranded, alpha-helical, heavy chain tail (myosin rod).
Myocytes, Cardiac
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Adenosine Triphosphatases
A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.

Roles for the troponin tail domain in thin filament assembly and regulation. A deletional study of cardiac troponin T. (1/1295)

Striated muscle contraction is regulated by Ca2+ binding to troponin, which has a globular domain and an elongated tail attributable to the NH2-terminal portion of the bovine cardiac troponin T (TnT) subunit. Truncation of the bovine cardiac troponin tail was investigated using recombinant TnT fragments and subunits TnI and TnC. Progressive truncation of the troponin tail caused progressively weaker binding of troponin-tropomyosin to actin and of troponin to actin-tropomyosin. A sharp drop-off in affinity occurred with NH2-terminal deletion of 119 rather than 94 residues. Deletion of 94 residues had no effect on Ca2+-activation of the myosin subfragment 1-thin filament MgATPase rate and did not eliminate cooperative effects of Ca2+ binding. Troponin tail peptide TnT1-153 strongly promoted tropomyosin binding to actin in the absence of TnI or TnC. The results show that the anchoring function of the troponin tail involves interactions with actin as well as with tropomyosin and has comparable importance in the presence or absence of Ca2+. Residues 95-153 are particularly important for anchoring, and residues 95-119 are crucial for function or local folding. Because striated muscle regulation involves switching among the conformational states of the thin filament, regulatory significance for the troponin tail may arise from its prominent contribution to the protein-protein interactions within these conformations.  (+info)

Tissue-specific distribution of breast-muscle-type and leg-muscle-type troponin T isoforms in birds. (2/1295)

In order to show the tissue-specific distribution of troponin T (TnT) isoforms in avian skeletal muscles, their expression was examined by electrophoresis of the breast and leg muscles of seven avian species and immunoblotting with the antiserum against fast skeletal muscle TnT. It has been reported in the chicken that breast-muscle-type (B-type) and leg-muscle-type (L-type) TnT isoforms are expressed specifically in the adult breast and leg muscles, respectively. Their differential expression patterns were confirmed in all birds examined in this study. The expression of a segment encoded by the exon x series of TnT was also examined by immunoblotting with the antiserum against a synthetic peptide derived from the exon x3 sequence, because the segment has been shown to be included exclusively in the B-type, but not in the L-type TnT. The expression of the segment was found only in the breast muscle, but not in the leg muscle of all birds examined. TnT cDNA sequences from the duck breast and leg muscles were determined and showed that only B-type TnT had an exon x-related sequence, suggesting that the expression of B-type TnT containing the exon x-derived segment is conserved consistently in the birds.  (+info)

Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy. (3/1295)

Human wild-type cardiac troponin T, I, C and five troponin T mutants (I79N, R92Q, F110I, E244D, and R278C) causing familial hypertrophic cardiomyopathy were expressed in Escherichia coli, and then were purified and incorporated into rabbit cardiac myofibrils using a troponin exchange technique. The Ca2+-sensitive ATPase activity of these myofibrillar preparations was measured in order to examine the functional consequences of these troponin mutations. An I79N troponin T mutation was found to cause a definite increase in Ca2+ sensitivity of the myofibrillar ATPase activity without inducing any significant change in the maximum level of ATPase activity. A detailed analysis indicated the inhibitory action of troponin I to be impaired by the I79N troponin T mutation. Two more troponin T mutations (R92Q and R278C) were also found to have a Ca2+-sensitizing effect without inducing any change in maximum ATPase activity. Two other troponin T mutations (F110I and E244D) had no Ca2+-sensitizing effects on the ATPase activity, but remarkably potentiated the maximum level of ATPase activity. These findings indicate that hypertrophic cardiomyopathy-linked troponin T mutations have at least two different effects on the Ca2+-sensitive ATPase activity, Ca2+-sensitization and potentiation of the maximum level of the ATPase activity.  (+info)

Characterization of the cardiac holotroponin complex reconstituted from native cardiac troponin T and recombinant I and C. (4/1295)

Cardiac troponin I (cTnI), the inhibitory subunit of cardiac troponin (cTn), is phosphorylated by the cAMP-dependent protein kinase A at two adjacently located serine residues within the heart-specific N-terminal elongation. Four different phosphorylation states can be formed. To investigate each monophosphorylated form cTnI mutants, in which each of the two serine residues is replaced by an alanine, were generated. These mutants, as well as the wild-type cardiac troponin I (cTnI-WT) have been expressed in Escherichia coli, purified and characterized by isoelectric focusing, MS and CD-spectroscopy. Monophosphorylation induces conformational changes within cTnI that are different from those induced by bisphosphorylation. Functionality was assessed by measuring the calcium dependence of myosin S1 binding to thin filaments containing reconstituted native, wild-type and mutant cTn complexes. In all cases a functional holotroponin complex was obtained. Upon bisphosphorylation of cTnI-WT the pCa curve was shifted to the right to the same extent as that observed with bisphosphosphorylated native cTnI. However, the absolute values for the midpoints were higher when recombinant cTn subunits were used for reconstitution. Reconstitution itself changed the calcium affinity of cTnC: pCa50-values were higher than those obtained with the native cardiac holotroponin complex. Apparently only bisphosphorylation of cTnI influences the calcium sensitivity of the thin filament, thus monophosphorylation has a function different from that of bisphosphorylation; this function has not yet been identified.  (+info)

Diagnostic marker cooperative study for the diagnosis of myocardial infarction. (5/1295)

BACKGROUND: Millions of patients present annually with chest pain, but only 10% to 15% have myocardial infarction. Lack of diagnostic sensitivity and specificity of clinical and conventional markers prevents or delays treatment and leads to unnecessary costly admissions. Comparative data are lacking on the new markers, yet using all of them is inappropriate and expensive. METHODS AND RESULTS: The Diagnostic Marker Cooperative Study was a prospective, multicenter, double-blind study with consecutive enrollment of patients with chest pain presenting to the emergency department. Diagnostic sensitivity and specificity and frequency of increase in patients with unstable angina were determined for creatine kinase-MB (CK-MB) subforms, myoglobin, total CK-MB (activity and mass), and troponin T and I on the basis of frequent serial sampling for +info)

Effects of the prostanoid EP3-receptor agonists M&B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat. (6/1295)

1. This study investigates the effects of two agonists of the prostanoid EP3-receptor (M&B 28767 and GR 63799X) on the infarct size caused by regional myocardial ischaemia and reperfusion in the anaesthetized rat. 2. One hundred and sixty-seven, male Wistar rats were anaesthetized (thiopentone, 120 mg kg(-1) i.p.), ventilated (8-10 ml kg(-1), 70 strokes min(-1), inspiratory oxygen concentration: 30%; PEEP: 1-2 mmHg) and subjected to occlusion of the left anterior descending coronary artery (LAD, for 7.5, 15, 25, 35, 45 or 60 min) followed by reperfusion (2 h). Infarct size was determined by staining of viable myocardium with a tetrazolium stain (NBT), histological evaluation by light and electron microscopy and determination of the plasma levels of cardiac troponin T. 3. M&B 28767 (0.5 microg kg(-1) min(-1), i.v., n=7) or GR 63799X (3 microg kg(-1) min(-1), i.v., n=7) caused significant reductions in infarct size from 60+/-3% (25 min ischaemia and 2 h reperfusion; saline-control, n=8) to 39+/-6 and 38+/-4% of the area at risk, without causing a significant fall in blood pressure. Pretreatment of rats with 5-hydroxydecanoate (5-HD), an inhibitor of ATP-sensitive potassium channels, attenuated the cardioprotective effects of both EP3-receptor agonists. The reduction in infarct size afforded by M&B 28767 was also abolished by glibenclamide and the protein kinase C (PKC) inhibitors staurosporine and chelerythrine. 4. Thus, M&B 28767 and GR 63799X reduce myocardial infarct size in the rat by a mechanism(s) which involves the activation of PKC and the opening of ATP-sensitive potassium channels.  (+info)

Intraoperative cardiac troponin T release and lactate metabolism during coronary artery surgery: comparison of beating heart with conventional coronary artery surgery with cardiopulmonary bypass. (7/1295)

OBJECTIVE: To compare cardiac troponin T release and lactate metabolism in coronary sinus and arterial blood during uncomplicated coronary grafting on the beating heart with conventional coronary grafting using cardiopulmonary bypass. DESIGN: A prospective observational study with simultaneous sampling of coronary sinus and arterial blood: before and 1, 4, 10, and 20 minutes after reperfusion for analysis of cardiac troponin T and lactate. Cardiac troponin T was also analysed in venous samples taken 3, 6, 24, 48, and 72 hours after surgery. SETTING: Cardiac surgical unit in a tertiary referral centre. PATIENTS: 18 patients undergoing coronary grafting on the beating heart (10 single vessel and eight two-vessel grafting) and eight undergoing two-vessel grafting with cardiopulmonary bypass. RESULTS: Cardiac troponin T was detected in coronary sinus blood in all patients by 20 minutes after beating heart coronary artery surgery before arterial concentrations were consistently increased. Peak arterial and coronary sinus cardiac troponin T values on the beating heart during single (0.03 (0 to 0. 05) and 0.09 (0.07 to 0.16 microg/l, respectively) and two-vessel grafting (0.1 (0.07 to 0.11) and 0.19 (0.14 to 0.25) microg/l) were lower than the values obtained during cardiopulmonary bypass (0.64 (0.52 to 0.72) and 1.4 (0.9 to 2.0) microg/l) (p < 0.05). The area under the curve of venous cardiac troponin T over 72 hours for two-vessel grafting on the beating heart was less than with cardiopulmonary bypass (13 (10 to 16) v 68 (26 to 102) microg.h/l) (p < 0.001). Lactate extraction began within one minute of snare release during beating heart coronary surgery while lactate was still being produced 20 minutes after cross clamp release following cardiopulmonary bypass. CONCLUSIONS: Lower intraoperative and serial venous cardiac troponin T concentrations suggest a lesser degree of myocyte injury during beating heart coronary artery surgery than during cardiopulmonary bypass. Oxidative metabolism also recovers more rapidly with beating heart coronary artery surgery than with conventional coronary grafting. Coronary sinus cardiac troponin T concentrations increased earlier and were greater than arterial concentrations during beating heart surgery, suggesting that this may be a more sensitive method of intraoperative assessment of myocardial injury.  (+info)

Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events. (8/1295)

BACKGROUND: A growing body of evidence suggests a role for inflammation in acute coronary syndromes. The aim of this study was to assess the role of proinflammatory cytokines, their time course, and their association with prognosis in unstable angina. METHODS AND RESULTS: We studied 43 patients aged 62+/-8 years admitted to our coronary care unit for Braunwald class IIIB unstable angina. In each patient, serum levels of interleukin-1 receptor antagonist (IL-1Ra), interleukin-6 (IL-6) (which represent sensitive markers of biologically active IL-1beta and tumor necrosis factor-alpha levels, respectively), and troponin T were measured at entry and 48 hours after admission. Troponin T-positive patients were excluded. Patients were divided a posteriori into 2 groups according to their in-hospital outcome: group 1 comprised 17 patients with an uneventful course, and group 2 comprised 26 patients with a complicated in-hospital course. In group 1, mean IL-1Ra decreased at 48 hours by 12%, and IL-6 diminished at 48 hours by 13%. In group 2, IL-1Ra and IL-6 entry levels were higher than in group 1 and increased respectively by 37% and 57% at 48 hours (P<0.01). CONCLUSIONS: These findings indicate that although they receive the same medical therapy as patients who do not experience an in-hospital event, patients with unstable angina and with complicated in-hospital courses have higher cytokine levels on admission. A fall in IL-1Ra and IL-6 48 hours after admission was associated with an uneventful course and their increase with a complicated hospital course. These findings may suggest novel therapeutic approaches to patients with unstable angina.  (+info)

Utility of high-sensitivity cardiac troponin T in patients receiving anthracycline chemotherapy<...Utility of high-sensitivity cardiac troponin T in patients receiving anthracycline chemotherapy<...
TY - JOUR. T1 - Utility of high-sensitivity cardiac troponin T in patients receiving anthracycline chemotherapy. AU - Blaes, Anne H.. AU - Rehman, Aamer. AU - Vock, David M.. AU - Luo, Xianghua. AU - Menge, Mark. AU - Yee, Douglas. AU - Missov, Emil. AU - Duprez, Daniel. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Background: Anthracycline chemotherapy remains an integral part of the care for curative intent chemotherapy in breast cancer and non-Hodgkin lymphoma patients. Better tools need to be identified to predict cardiac complications of anthracycline chemotherapy. Materials and methods: We investigated the utility of high-sensitivity cardiac troponin T (hscTnT), N-terminal pro-B-type natriuretic peptide, cardiac troponin T and I, and creatine kinase (CK)-MB in cancer patients receiving anthracycline-based chemotherapy, in order to determine whether baseline levels or changes in these biomarkers may help predict the onset of congestive heart failure. Results: Eighteen consecutive patients with a ...
https://experts.umn.edu/en/publications/utility-of-high-sensitivity-cardiac-troponin-t-in-patients-receiv
Combined evaluation of coronary artery disease and high-sensitivity cardiac troponin T for prediction of adverse events in...Combined evaluation of coronary artery disease and high-sensitivity cardiac troponin T for prediction of adverse events in...
This study was performed to investigate the clinical significance of combined evaluation of both coronary artery disease (CAD) and high-sensitivity cardiac troponin T (hs-cTnT) for prediction of major adverse cardiovascular events (MACEs) in patients with hypertrophic cardiomyopathy (HCM). We performed clinical evaluations, including coronary artery imaging and hs-cTnT measurement, in 162 patients with HCM. The patients were followed up for a median period of 3.7 years (interquartile range 2.4-5.6 years; total of 632.3 person-years [PYs]), during which time MACEs occurred in 24 (14.8%) patients. The incidence of MACEs was 6.4 and 2.7 per 100 PYs for patients with CAD and normal coronary arteries, respectively; similarly, the incidence was 5.8 and 2.1 per 100 PYs in patients with an elevated hs-cTnT concentration (| 14.0 ng/L) and a normal hs-cTnT concentration, respectively. The multivariate analysis suggested that CAD and an elevated hs-cTnT concentration tended to be positively associated with MACEs.
https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-021-02135-x
Abstract 10893: Cardiac Troponin T Release is Correlated with Diastolic Load in Patients with Nonischemic Heart Failure |...Abstract 10893: Cardiac Troponin T Release is Correlated with Diastolic Load in Patients with Nonischemic Heart Failure |...
Background: Cardiac troponin T (cTnT) is established as a specific biomarker of ongoing myocardial damage and predicts adverse outcome in patients with heart failure (HF). As is well known that epicardial coronary artery disease increases cTnT level by myocardial ischemia. However, it is not fully understood the mechanism underlying cTnT release in nonischemic HF patients because cTnT was detectable in only a small fraction by standard cTnT assay and affected by renal function. We evaluated cTnT release by novel highly sensitive assay and identified the affecting factors.. Methods: We evaluated 53 nonischemic HF patients (HF group: mean age 61±16 years, ejection fraction: 44±12 %, male 34) and 19 non-HF patients without significant coronary artery disease as a control group. We sampled from aortic root (Ao) and coronary sinus (CS) simultaneously during cardiac catheterization, and measured serum cTnT levels using Elecsys-2010 Troponin T hs STAT kit (Roche Diagnostics) and plasma B-type ...
http://circ.ahajournals.org/content/124/Suppl_21/A10893
Intraoperative cardiac troponin T release and lactate metabolism during coronary artery surgery: comparison of beating heart...Intraoperative cardiac troponin T release and lactate metabolism during coronary artery surgery: comparison of beating heart...
Beating heart surgery allows coronary artery bypass grafting to be performed without the attendant disadvantages, both cerebral and myocardial, of cardiopulmonary bypass.16 It was our aim in the present study to compare the extent of myocardial damage associated with these two techniques using cardiac troponin T,13 17 18 a specific marker with negligible cross reactivity with skeletal muscle.10 In addition, we aimed to increase the sensitivity of this method still further by estimating cardiac troponin T in both coronary sinus and peripheral artery, so that myocardial release could be detected.7 Using this approach, we found that all patients undergoing beating heart coronary artery surgery had detectable cardiac troponin T in coronary sinus blood within 20 minutes of release of the coronary snare. In contrast, even by 20 minutes peripheral arterial concentrations were consistently less raised, and remained less than coronary sinus concentrations throughout the intraoperative period, showing net ...
http://heart.bmj.com/content/81/5/495
Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties...
Familial hypertrophic cardiomyopathy (HCM) is caused by mutations in at least 8 contractile protein genes, most commonly beta myosin heavy chain, myosin binding protein C, and cardiac troponin T. Affected individuals are heterozygous for a particular mutation, and most evidence suggests that the mutant protein acts in a dominant-negative fashion. To investigate the functional properties of a truncated troponin T shown to cause HCM, both wild-type and mutant human cardiac troponin T were overexpressed in Escherichia coli, purified, and combined with human cardiac troponins I and C to reconstitute human cardiac troponin. Significant differences were found between the regulatory properties of wild-type and mutant troponin in vitro, as follows. (1) In actin-tropomyosin-activated myosin ATPase assays at pCa 9, wild-type troponin caused 80% inhibition of ATPase, whereas the mutant complex gave negligible inhibition. (2) Similarly, in the in vitro motility assay, mutant troponin failed to decrease both the
https://www.cardioscience.ox.ac.uk/publications/104205
DIGITAL.CSIC: Two functionally identical modular enhancers in Drosophila troponin T gene establish the correct protein levels...DIGITAL.CSIC: Two functionally identical modular enhancers in Drosophila troponin T gene establish the correct protein levels...
The control of muscle-specific expression is one of the principal mechanisms by which diversity is generated among muscle types. In an attempt to elucidate the regulatory mechanisms that control fiber diversity in any given muscle, we have focused our attention on the transcriptional regulation of the Drosophila Troponin T gene. Two, nonredundant, functionally identical, enhancer-like elements activate Troponin T transcription independently in all major muscles of the embryo and larvae as well as in adult somatic and visceral muscles. Here, we propose that the differential but concerted interaction of these two elements underlies the mechanism by which a particular muscle-type establish the correct levels of Troponin T expression, adapting these levels to their specific needs. This mechanism is not exclusive to the Troponin T gene, but is also relevant to the muscle-specific Troponin I gene. In conjunction with in vivo transgenic studies, an in silico analysis of the Troponin T enhancer-like ...
https://digital.csic.es/handle/10261/24602
Histological evidence for reversible cardiomyocyte changes and serum cardiac troponin T elevation after exercise in rats. |...Histological evidence for reversible cardiomyocyte changes and serum cardiac troponin T elevation after exercise in rats. |...
This study characterized cardiac troponin T (cTnT) appearance and associated histological evidence of reversible or irreversible changes in myocardial ultrastructure, determined via electron microscopy, in rats undertaking isoproterenol (ISO) infusion or an endurance exercise challenge. Male rats were randomized into ISO and exercise groups. In ISO trials rats were killed 5 h (ISO-5H) and 24 h (ISO-REC19H) after a single ISO or saline injection (SAL-5H; SAL-REC19H). In the exercise trials rats were killed before, as a control (EXE-CON), immediately after (EXE-END5H) and 19 h after (EXE-REC19H) a 5-h bout of swimming with 5% body weight attached to their tail. Serum cTnT was quantified by electrochemiluminescence, and myocardial samples in ISO-REC19H, EXE-REC19H and SAL-REC19H were harvested for assessment of specific mitochondrial injury scores using electron-microscopy. cTnT was undetectable in all control animals (SAL-5H/SAL-REC19H and EXE-CON). cTnT increased in all animals after ISO and ...
http://researchonline.ljmu.ac.uk/5374/
Elevated Plasma Cardiac Troponin T Levels Caused by Skeletal Muscle Damage in Pompe DiseaseCLINICAL PERSPECTIVE | Circulation:...Elevated Plasma Cardiac Troponin T Levels Caused by Skeletal Muscle Damage in Pompe DiseaseCLINICAL PERSPECTIVE | Circulation:...
We found that plasma cTnT but not cTnI levels were increased in the majority of patients with Pompe disease, and that cTnT levels correlated with CK levels. Elevated cTnT levels could not be explained by cardiac abnormalities. cTnT was expressed in skeletal muscle biopsies taken from patients with Pompe disease, but not from healthy individuals. We conclude that increased plasma cTnT levels in patients with Pompe disease are most likely the result of skeletal muscle damage, rather than myocardial damage.. Cardiac troponins are the preferred biomarkers for detection of AMI. According to an expert consensus document for the universal definition of myocardial infarction, AMI should be diagnosed if a rise or fall of cardiac biomarkers is detected (preferably cTnT or cTnI), with at least 1 value above the 99th percentile cut-off value. These changes need to be accompanied by symptoms of ischemia, ECG changes, imaging evidence of recent loss of viable myocardium, or new regional wall motion ...
http://circgenetics.ahajournals.org/content/9/1/6
Multicenter analytical evaluation of a high-sensitivity troponin T assay - edocMulticenter analytical evaluation of a high-sensitivity troponin T assay - edoc
Saenger, A. K. and Beyrau, R. and Braun, S. and Cooray, R. and Dolci, A. and Freidank, H. and Giannitsis, E. and Gustafson, S. and Handy, B. and Katus, H. and Melanson, S. E. and Panteghini, M. and Venge, P. and Zorn, M. and Jarolim, P. and Bruton, D. and Jarausch, J. and Jaffe, A. S. ...
https://edoc.unibas.ch/29374/
Cardiac structural and functional abnormalities in end stage renal disease patients with elevated cardiac troponin T | HeartCardiac structural and functional abnormalities in end stage renal disease patients with elevated cardiac troponin T | Heart
Objectives: To identify in a prospective observational study the cardiac structural and functional abnormalities and mortality in patients with end stage renal disease (ESRD) with a raised cardiac troponin T (cTnT) concentration.. Methods: 126 renal transplant candidates were studied over a two year period. Clinical, biochemical, echocardiographic, coronary angiographic, and dobutamine stress echocardiographic (DSE) data were examined in comparison with cTnT concentrations dichotomised at cut off concentrations of , 0.04 μg/l and , 0.10 μg/l.. Results: Left ventricular (LV) size and filling pressure were significantly raised and LV systolic and diastolic function parameters significantly impaired in patients with raised cTnT, irrespective of the cut off concentration. The proportions of patients with diabetes and on dialysis were higher in both groups with raised cTnT. With a cut off cTnT concentration of 0.04 μg/l but not 0.10 μg/l, significantly more patients had severe coronary artery ...
http://heart.bmj.com/content/92/6/804
Expression and functional properties of four slow skeletal troponin T isoforms in rat muscles - Kischel PhilippeExpression and functional properties of four slow skeletal troponin T isoforms in rat muscles - Kischel Philippe
en] We investigated the expression and functional properties of slow skeletal troponin T(sTnT) isoforms in rat skeletal muscles. Four sTnT cDNAs were cloned from the slow soleus muscle. Three isoforms were found to be similar to sTnT1, sTnT2, and sTnT3 isoforms described in mouse muscles. A new rat isoform, with a molecular weight slightly higher than that of sTnT3, was discovered. This fourth isoform had never been detected previously in any skeletal muscle and was therefore called sTnTx. From both expression pattern and functional measurements, it appears that sTnT isoforms can be separated into two classes, high-molecular-weight ( sTnT1, sTnT2) and low-molecular-weight ( sTnTx, sTnT3) isoforms. By comparison to the apparent migration pattern of the four recombinant sTnT isoforms, the newly described low-molecular-weight sTnTx isoform appeared predominantly and typically expressed in fast skeletal muscles, whereas the higher-molecular-weight isoforms were more abundant in slow soleus muscle. ...
http://orbi.ulg.ac.be/handle/2268/12067
High-Sensitivity Troponin T and Coronary Computed Tomography Angiography for Rapid Diagnosis of Emergency Chest Pain - Tabular...High-Sensitivity Troponin T and Coronary Computed Tomography Angiography for Rapid Diagnosis of Emergency Chest Pain - Tabular...
The purpose of this study is to determine the efficacy and safety of an evaluation strategy based on utilization of high sensitivity cardiac troponin T (hscTnT), followed by coronary computed tomography angiography (CCTA) in patients with low-intermediate risk chest pain consistent with a possible acute coronary syndrome compared to a standard of care (SOC) strategy ...
https://clinicaltrials.gov/ct2/show/record/NCT01836211?show_rss=Y&sel_rss=mod14
Elevated baseline cardiac troponin T confers worse outcomes in VICTORIA populationElevated baseline cardiac troponin T confers worse outcomes in VICTORIA population
Elevated baseline high-sensitivity cardiac troponin T was associated with CV death and HF hospitalization in patients from the VICTORIA trial, according to a presentation at the American College of Cardiology Scientific Session.The researchers analyzed whether baseline cardiac troponin T was associated with the VICTORIA trial’s primary endpoint of CV death or HF hospitalization and its
https://www.healio.com/news/cardiology/20210611/elevated-baseline-cardiac-troponin-t-confers-worse-outcomes-in-victoria-population
High-Sensitivity Troponin I and Incident Coronary Events, Stroke, Heart Failure Hospitalization, and Mortality in the ARIC...High-Sensitivity Troponin I and Incident Coronary Events, Stroke, Heart Failure Hospitalization, and Mortality in the ARIC...
BACKGROUND: We assessed whether plasma troponin I measured by a high-sensitivity assay (hs-TnI) is associated with incident cardiovascular disease (CVD) and mortality in a community-based sample without prior CVD.. METHODS: ARIC study (Atherosclerosis Risk in Communities) participants aged 54 to 74 years without baseline CVD were included in this study (n=8121). Cox proportional hazards models were constructed to determine associations between hs-TnI and incident coronary heart disease (CHD; myocardial infarction and fatal CHD), ischemic stroke, atherosclerotic CVD (CHD and stroke), heart failure hospitalization, global CVD (atherosclerotic CVD and heart failure), and all-cause mortality. The comparative association of hs-TnI and high-sensitivity troponin T with incident CVD events was also evaluated. Risk prediction models were constructed to assess prediction improvement when hs-TnI was added to traditional risk factors used in the Pooled Cohort Equation.. RESULTS: The median follow-up period ...
https://sites.cscc.unc.edu/aric/node/13498
Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost-consequence analysis.Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost-consequence analysis.
BACKGROUND: Myocardial injury after noncardiac surgery (MINS) is a mostly asymptomatic condition that is strongly associated with 30-day mortality; however, it remains mostly undetected without systematic troponin T monitoring. We evaluated the cost and consequences of postoperative troponin T monitoring to detect MINS. METHODS: We conducted a model-based cost-consequence analysis to compare the impact of routine troponin T monitoring versus standard care (troponin T measurement triggered by ischemic symptoms) on the incidence of MINS detection. Model inputs were based on Canadian patients enrolled in the Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) study, which enrolled patients aged 45 years or older undergoing inpatient noncardiac surgery. We conducted probability analyses with 10 000 iterations and extensive sensitivity analyses. RESULTS: The data were based on 6021 patients (48% men, mean age 65 [standard deviation 12] yr). The 30-day mortality rate for MINS was ...
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39863
Initial troponin level as a predictor of prognosis in patients with intracerebral hemorrhage<...Initial troponin level as a predictor of prognosis in patients with intracerebral hemorrhage<...
TY - JOUR. T1 - Initial troponin level as a predictor of prognosis in patients with intracerebral hemorrhage. AU - Chung, Pil Wook. AU - Won, Yu Sam. AU - Kwon, Young Joan. AU - Choi, Chum Sik. AU - Kim, Byung Moon. PY - 2009. Y1 - 2009. N2 - Objective: It has been suggested that elevated cardiac troponin T (cTnT) level is a marker of increased risk of mortality in acute ischemic stroke and subarachnoid hemorrhage (SAH). However, the association of serum cTnT level and prognosis of intracerebral hemorrhage (ICH) has been sparsely investigated. The aim of this study was to identify the relationship between cTnT level and the outcome in patients with spontaneous ICH. Methods: We retrospectively investigated 253 patients identified by a database search from records of patients admitted in our department for ICH between January 1, 2003 and December 31, 2007. The patients were divided into 2 groups; the patients in group 1 (n=225) with serum cTnT values of 0.01 ng/mL or less, and those in group 2 ...
https://yonsei.pure.elsevier.com/en/publications/initial-troponin-level-as-a-predictor-of-prognosis-in-patients-wi
Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy -...Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy -...
Animals have frequently been used as models for human disorders and mutations. Following advances in genetic testing and treatment options, and the decreasing cost of these technologies in the clinic, mutations in both companion and commercial animals are now being investigated. A recent review highlighted the genes associated with both human and non-human dilated cardiomyopathy. Cardiac troponin T and dystrophin were observed to be associated with both human and turkey (troponin T) and canine (dystrophin) dilated cardiomyopathies. This review gives an overview of the work carried out in cardiac troponin T and dystrophin to date in both human and animal dilated cardiomyopathy.. ...
http://eprints.nottingham.ac.uk/44092/
High-sensitivity cardiac troponin and natriuretic peptide with risk of lower-extremity peripheral artery disease: the...High-sensitivity cardiac troponin and natriuretic peptide with risk of lower-extremity peripheral artery disease: the...
TY - JOUR. T1 - High-sensitivity cardiac troponin and natriuretic peptide with risk of lower-extremity peripheral artery disease. T2 - the Atherosclerosis Risk in Communities (ARIC) Study. AU - Matsushita, Kunihiro. AU - Kwak, Lucia. AU - Yang, Chao. AU - Pang, Yuanjie. AU - Ballew, Shoshana H.. AU - Sang, Yingying. AU - Hoogeveen, Ron C.. AU - Jaar, Bernard G.. AU - Selvin, Elizabeth. AU - Ballantyne, Christie M.. AU - Sharrett, A. Richey. AU - Folsom, Aaron R.. AU - Heiss, Gerardo. AU - Coresh, Josef. AU - Hirsch, Alan T.. PY - 2018/7/1. Y1 - 2018/7/1. N2 - Aims Cardiac troponin T (cTnT) is suggested as a predictor of amputation in patients with peripheral artery disease (PAD). However, cTnT-PAD association has not been systematically studied in a large study. This study evaluated the association of high-sensitivity cTnT (hs-cTnT) with PAD incidence and also explored whether natriuretic peptide (NT-proBNP), another representative cardiac marker, predicts PAD risk. Methods Among 12 288 ...
https://experts.umn.edu/en/publications/high-sensitivity-cardiac-troponin-and-natriuretic-peptide-with-ri
Cardiac troponin T circulates in the free, intact form in patients with kidney failure. - Kent Academic RepositoryCardiac troponin T circulates in the free, intact form in patients with kidney failure. - Kent Academic Repository
BACKGROUND: The clinical significance of the increased concentrations of cardiac troponins observed in patients with end stage renal disease (ESRD) in the absence of an acute coronary syndrome (ACS) is controversial. One proposed explanation is that immunoreactive fragments of cardiac troponin T (cTnT) accumulate in ESRD. We used gel-filtration chromatography (GFC) to ascertain whether fragments of cTnT, which could cross-react in the commercial diagnostic immunoassay (Roche Diagnostics), were the cause of the increased cTnT in the serum of patients with ESRD. METHODS: We subjected sera from ESRD patients (n = 21) receiving dialysis and having increased cTnT concentrations to size-separation GFC. We detected cTnT in the chromatography fractions by use of the same antibodies used in the commercial assay for serum cTnT. RESULTS: In all patients, cTnT immunoreactivity eluted as a major, homogeneous peak in an identical position between the peaks of serum prolactin [relative molecular mass (Mr) ...
https://kar.kent.ac.uk/100/
Impact Of Markedly Elevated Initial High -Sensitivity Cardiac Troponin T On Prediction Of Acute Myocardial Infarction In Chest...Impact Of Markedly Elevated Initial High -Sensitivity Cardiac Troponin T On Prediction Of Acute Myocardial Infarction In Chest...
Impact Of Markedly Elevated Initial High -Sensitivity Cardiac Troponin T On Prediction Of Acute Myocardial Infarction In Chest Pain Patients And Additional Value Of Kinetic Changes: Results From The Trapid-AMI Study ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:1045811
Abstract 1793: Statins Reduce Perioperative Myocardial Ischemia, Troponin T Release and Mortality in Major Vascular Surgery |...Abstract 1793: Statins Reduce Perioperative Myocardial Ischemia, Troponin T Release and Mortality in Major Vascular Surgery |...
Background: HMG-CoA reductase inhibitors (statins) improve mortality in high-risk patients. Statins may have beneficial properties beyond its lipid-lowering potential, including inflammation reduction and atherosclerotic plaque stabilization. In this study, we examined whether statins can reduce perioperative myocardial ischemia and improve long-term outcome in patients undergoing major vascular surgery.. Methods: A total of 213 consecutive patients (mean age 68 ± 10 years, 79% male) underwent surgery for abdominal aortic aneurysms or lower extremity bypass grafting. Statins were prescribed in 55% of the patients and serial cholesterol levels were measured 3 months and 1 week prior to surgery. Myocardial ischemia was assessed by continuous 12-lead ECG monitoring, starting 1 day before surgery and continuing for 3 days after. Serial troponin T measurements were performed on day 1, 3 and 7 after surgery. During follow-up, mortality was noted.. Results: In this study cohort, 71 patients (33%) had ...
http://circ.ahajournals.org/content/114/Suppl_18/II_353.5
High-Sensitivity Troponin Test Could Identify Low-Risk Chest Pain Patients in the ED - CardioExchange CardioExchangeHigh-Sensitivity Troponin Test Could Identify Low-Risk Chest Pain Patients in the ED - CardioExchange CardioExchange
Approximately 15-20 million people in Europe and the United States go to the emergency department every year with chest pain. Many can be discharged early if they are not having an acute coronary syndrome. A large, new, single-center observational study, presented at the American College of Cardiology meeting in Washington, DC and published simultaneously in the Journal of the American College of Cardiology, provides fresh evidence that high-sensitivity cardiac troponin T (hs-cTnT) may be useful in helping identify chest pain patients in the emergency department who do not need to be admitted to the hospital.. Nadia Bandstein reported on 14,636 patients who presented to the emergency department at a Swedish hospital and had a hs-cTnT test. Of these, 61% (8,907) had a hs-cTnT below 5 ng/l. At 30 days, only 0.44% (39) of these patients had an MI. None of the patients in this group died. A total of 15 had MIs with no ischemic ECG changes. The authors calculated a negative predictive value of ...
https://blogs.jwatch.org/cardioexchange/2014/03/30/new-troponin-test-could-identify-low-risk-chest-pain-patients-in-the-ed/
New Risk Score Promising for Predicting MI, Death | Physicians WeeklyNew Risk Score Promising for Predicting MI, Death | Physicians Weekly
Peter A. Kavsak, Ph.D., from McMaster University in Hamilton, Canada, and colleagues constructed a clinical chemistry score (CCS; range, 0 to 5 points) based on high-sensitivity cardiac troponin (hs-cTn), glucose level, and estimated glomerular filtration rate test results. The score was validated as a predictor of 30-day myocardial infarction (MI) or death using data from four cohorts involving 4,245 patients who presented to the emergency department with symptoms suggestive of acute coronary syndrome. A total of 17.1 percent of participants had an MI or died within 30 days.. The researchers found that low-risk patients were best identified with a CCS score of 0 points. High-sensitivity cardiac troponin I (hs-cTnI) CCS had a sensitivity of 100 percent, with 8.9 percent of the population classified as low risk of MI or death within 30 days; high-sensitivity cardiac troponin T (hs-cTnT) CCS had a sensitivity of 99.9 percent, with 10.5 percent of the population classified as low-risk. The CCS had ...
https://www.physiciansweekly.com/new-risk-score-promising-for-predicting-mi-death/
Troponin T, slow skeletal muscleTroponin T, slow skeletal muscle
This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008 ...
https://pharos.nih.gov/idg/targets/P13805
troponin | The British Journal of Cardiologytroponin | The British Journal of Cardiology
Introduction Most patients presenting as an emergency with chest pain do not have myocardial infarction (MI),1 which must, nevertheless, be ruled out in order to reassure and discharge from hospital. High-sensitivity cardiac troponin T (hs-TnT) and troponin I (hs-TnI) have streamlined the assessment and management of chest pain, as a rapid rule out of MI is now possible, particularly if hs-TnT or hs-TnI are undetectable at presentation.2-8 Undetectable troponin cannot, however, be used to exclude unstable angina, which by definition is not associated with a troponin rise.9 It is for this reason that physicians and cardiologists may be reluct. ...
https://bjcardio.co.uk/tag/troponin/
Use of hs-cTnT Assay Brings Increased Dx of Myocardial Injury, MI | Physicians WeeklyUse of hs-cTnT Assay Brings Increased Dx of Myocardial Injury, MI | Physicians Weekly
The use of high-sensitivity cardiac troponin-T (hs-cTnT) assays significantly increased the number of diagnoses of myocardial injury and myocardial infarction (MI), especially in women and those with type 2 MI; however, apart from angiography, it did not increase the use of overall resources. In patients without increases in cTnT, researchers documented more ED discharges and less cardiac testing.. In the first study of its kind, Olatunde Ola, MD, MPH, of the Mayo Clinic Health System, La Crosse, Wisconsin, and colleagues assessed the transition from a contemporary cardiac troponin T (cTnT) assay that used an overall 99th percentile (4th generation) to a high-sensitivity (hs) cTnT assay with sex-specific 99thpercentiles (5th generation) for the diagnosis of myocardial injury and infarction (MI). Their results were published in the Journal of the American College of Cardiology.. The Roche 5th Gen cTnT assay, referred to as hs-cTnT, received United States (US) Food and Drug Administration (FDA) ...
https://www.physiciansweekly.com/use-of-hs-ctnt-assay-brings-increased-dx-of-myocardial-injury-mi/
The Effect of Anesthetic Technique on Cardiac Troponin-T and Systemic Inflammatory Response after Major Abdominal Cancer...The Effect of Anesthetic Technique on Cardiac Troponin-T and Systemic Inflammatory Response after Major Abdominal Cancer...
The Effect of Anesthetic Technique on Cardiac Troponin-T and Systemic Inflammatory Response after Major Abdominal Cancer Surgery Abstract.
https://www.omicsonline.org/peer-reviewed/the-effect-of-anesthetic-technique-on-cardiac-troponint-and-systemic-inflammatory-response-after-major-abdominal-cancer-surgery-11994.html
Cardiac Troponin T (human) AlphaLISA Detection Kit, 500 Assay Points| PerkinElmer
Detect and quantitate human cardiac troponin T in human serum, plasma and cell culture supernantants using a homogeneous AlphaLISA no-wash assay.
https://www-punchout.perkinelmer.com/product/alphalisa-ctnt-hu-500pts-al3011c
NewsCAP: A new algorithm speeds the diagnosis of acute myocardial infarction (AMI) in ED patients with chest pain | Article |...NewsCAP: A new algorithm speeds the diagnosis of acute myocardial infarction (AMI) in ED patients with chest pain | Article |...
A new algorithm speeds the diagnosis of acute myocardial infarction (AMI) in ED patients with chest pain. Researchers measured levels of high-sensitivity cardiac troponin T (hs-cTnT) when patients arrived at the ED, then again one hour later. AMI was ruled in when baseline hs-cTnT levels were 52 ng/L or higher or if they had increased 5 ng/L in the first hour. AMI was ruled out when baseline hs-cTnT levels fell below 12 ng/L and the first hourly change was less than 3 ng/L. Among 436 ED patients with acute chest pain, the algorithm diagnosed AMI in 17%. AMI was ruled out in 60%, and 23% remained under observation. The 30-day survival rate was 95.3% with a ruled-in AMI, 99.8% in those with an AMI ruled out, and 98.6% in those undergoing continued observation. The algorithm, described in the September 10 Archives of Internal Medicine, may prevent unnecessary blood sampling and shorten the time to AMI diagnosis and treatment.. ...
https://www.nursingcenter.com/journalarticle?Article_ID=1453786&Journal_ID=54030&Issue_ID=1453749
Rat Cardiac Troponin T(cTn-T)ELISA kit 酶联免疫试剂盒 专业提供基因,重组蛋白,抗体,ELISA kit,诊断试剂原料,定制服务-华美生物Rat Cardiac Troponin T(cTn-T)ELISA kit 酶联免疫试剂盒 专业提供基因,重组蛋白,抗体,ELISA kit,诊断试剂原料,定制服务-华美生物
To assess the linearity of the assay, samples were spiked with high concentrations of rat cTn-T in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay ...
http://www.cusabio.cn/ELISA-Kit/Rat-Cardiac-Troponin-T
Impact of High-Sensitivity Cardiac Troponin Assay - American College of CardiologyImpact of High-Sensitivity Cardiac Troponin Assay - American College of Cardiology
The authors assessed data from 47 Swedish hospitals that introduced the new assay. There was an increase in use of echocardiography (from 48% to 52%) and coronary angiography (44% to 48%). In the second year, more at-risk patients were admitted and a cardiac troponin (cTn) level above the myocardial infarction cut-off was seen in a larger proportion of patients with both acute coronary syndrome (ACS) (+13.1%) and in patients with a diagnosis other than ACS (+160.1%). Patients with an elevated cTn level were at an increased risk of mortality in the second half of the study (adjusted hazard ratio [HR], 4.45; 95% confidence interval [CI], 3.36-5.89) compared with the initial study period (adjusted HR 2.43 [95% CI 2.11-2.80]), similar as for the cTn ratio relative to the respective 99th percentile. ...
http://www.acc.org/latest-in-cardiology/journal-scans/2016/03/10/16/19/consequences-of-implementing-a-cardiac-troponin-assay
Human Cardiac Troponin T: Cloning and Expression of New Isoforms in the Normal and Failing Heart | Circulation ResearchHuman Cardiac Troponin T: Cloning and Expression of New Isoforms in the Normal and Failing Heart | Circulation Research
This study confirms the recent assignment of the human cTnT gene to chromosome 1q21 and refines the location of the gene to 1q32 by physical mapping. No signal was observed on any other chromosome that might be accounted for by another troponin family gene. This chromosomal location supports our previous hypothesis that cardiac and slow skeletal TnT are encoded by distinct genes.15 Sequencing of five clones isolated from the fetal human heart cDNA library identified two variable boxes in the 5′ half of cTnT cDNA. The first box is composed of 30 bp coding for 10 amino acids (EEEDWREDED) and defining a highly acidic domain, which can be excised of the first amino acid (E) (Fig 2⇑). The resulting 27-bp box in the 5′ region of F-II-18 is identical to that recently reported by Townsend et al,21 but the existence of an additional amino acid at the 5′ end of this box in two other cDNAs (F-II-10 and F-II-16) shifts the limits of the variable domain by one amino acid (between amino acids 22 and ...
http://circres.ahajournals.org/content/76/4/687.long
EnglishEnglish
Abstract. - A high level of troponin correlates significantly with the risk of death or recurrence of myocardial infarction. However, most of these studies have been obtained in middle-aged people. It is considered that ageing is associated with increased troponin levels. This can be a major drawback for the stratification and diagnostic of acute coronary syndrome in elderly patients. Our study was designed to determine the predictive value of high-sensitivity cardiac troponin T (Hs-cTnT) in the elderly and very elderly patients and mainly in the presence of concomitant diseases. Materials and Methods: We retrospectively evaluated 6 977 medical records of patients aged ≥ 65 years and admitted for patients admitted to the hospital for chest pain. Three age groups were formed: patients aged 65 to 74 years (young-old), patients aged 75 to 84 years (old) and patients ≥85 years old (old-old). Three categories were formed according to the Hs-cTnT levels: 0-14 ng/L, 15-31 ng/L and ≥32 ng/L. ...
https://savoirs.usherbrooke.ca/handle/11143/12247?locale-attribute=en
Risk Stratification in Patients With Acute Chest Pain Using Three High-Sensitivity Cardiac Troponin Assays - American College...Risk Stratification in Patients With Acute Chest Pain Using Three High-Sensitivity Cardiac Troponin Assays - American College...
Eighty-two (7.3%) patients died during the follow-up. The 2-year prognostic accuracy of hs-cTn was most accurate for hs-cTnT (area under the receiver operating characteristic curve [AUC], 0.78; 95% confidence interval [CI], 0.73-0.83) and outperformed both hs-cTnI (Beckman-Coulter, 0.71; 95% CI, 0.65-0.77; p = 0.001 for comparison), hs-cTnI (Siemens, 0.70; 95% CI, 0.64-0.76; p < 0.001 for comparison), and cTnT (0.67; 95% CI, 0.61-0.74; p < 0.001 for comparison). Absolute changes of hs-cTnT were more accurate than relative changes in predicting mortality, but inferior to presentation values of hs-cTnT. Combining changes of hs-cTnT within the first 6 hours with their presentation values did not further improve prognostic accuracy. Similar results were obtained for both hs-cTnI assays regarding the incremental value of changes. Hs-cTn concentrations remained predictors of death in clinically challenging subgroups such as patients with pre-existing coronary artery disease, impaired renal function, ...
http://www.acc.org/latest-in-cardiology/journal-scans/2013/07/08/15/28/risk-stratification-in-patients-with-acute-chest-pain
Abnormal Contractile Function in Transgenic Mice Expressing a Familial Hypertrophic Cardiomyopathy-linked Troponin T (I79N)...
TY - JOUR. T1 - Abnormal Contractile Function in Transgenic Mice Expressing a Familial Hypertrophic Cardiomyopathy-linked Troponin T (I79N) Mutation. AU - Miller, Todd. AU - Szczesna, Danuta. AU - Housmans, Philippe R.. AU - Zhao, Jiaju. AU - De Freitas, Fatima. AU - Gomes, Aldrin V. AU - Culbreath, Lieneke. AU - McCue, Jessica. AU - Wang, Yi. AU - Xu, Yuanyuan. AU - Kerrick, W. Glenn L. AU - Potter, James D.. PY - 2001/2/9. Y1 - 2001/2/9. N2 - This study characterizes a transgenic animal model for the troponin T (TnT) mutation (I79N) associated with familial hypertrophic cardiomyopathy. To study the functional consequences of this mutation, we examined a wild type and two I79N-transgenic mouse lines of human cardiac TnT driven by a murine α-myosin heavy chain promoter. Extensive characterization of the transgenic I79N lines compared with wild type and/or nontransgenic mice demonstrated: 1) normal survival and no cardiac hypertrophy even with chronic exercise; 2) large increases in Ca2+ ...
https://ucdavis.pure.elsevier.com/en/publications/abnormal-contractile-function-in-transgenic-mice-expressing-a-fam
ORBi: Browsing ORBiORBi: Browsing ORBi
in Clinical Chemistry (2010, July), 56(S6), 127. Introduction: Cardiac troponin I and T are specific markers of myocardial injury that are widely used for the diagnosis of acute coronary syndrome (ACS). In acute chest pain without ST-segment elevation ... [more ▼]. Introduction: Cardiac troponin I and T are specific markers of myocardial injury that are widely used for the diagnosis of acute coronary syndrome (ACS). In acute chest pain without ST-segment elevation, they are used to differentiate unstable angina from non ST-segment elevation myocardial infarction (NSTEMI). Recently, troponin assays with higher analytical sensitivities became available to enable the detection of minor myocardial damage and identify individuals at higher risk for ACS. As a result of its high tissue-specificity, cardiac troponin T and I are cardio-specific, highly sensitive markers for myocardial damage. The aim of this study was to evaluate the new higher sensitive troponin (T and I) in patients with stable ...
https://orbi.uliege.be/browse?type=author&value=Merville%2C+Marie-Paule+p002705
Sciblogs | Emergency Department Archives - SciblogsSciblogs | Emergency Department Archives - Sciblogs
The majority of New Zealand emergency departments look for heart muscle damage by taking a sample of blood and looking for a particular molecule called a high-sensitivity troponin T (hsTnT). We have now confirmed that rather than two measurements over several hours just one measurement on arrival in the ED could be used to rule out heart attacks in about 30% … Read More ...
https://sciblogs.co.nz/tag/emergency-department/
The diagnostic challenge of myocardial infarction in critically ill patients: do high-sensitivity troponin measurements add...The diagnostic challenge of myocardial infarction in critically ill patients: do high-sensitivity troponin measurements add...
In ICU settings, the diagnosis and treatment of acute myocardial infarction (AMI) are challenging, partly because cardiac troponin increase occurs frequently. In the previous issue of Critical Care, Ostermann and colleagues reported that myocardial infarction (MI), screened by plasma troponin and electrocardiography changes, is common and often clinically unrecognized in the ICU. Although the clinical significance of underdiagnosed MIs remains unclear, this approach may help to target and further investigate the at-risk population for appropriate therapy.
https://ccforum.biomedcentral.com/articles/10.1186/cc13909
Troponin T Kidney Failure 2019 • Kidney Treatment
Troponin, or the troponin complex, is a complex of three regulatory proteins (troponin C, troponin I, and troponin T) that is integral to muscle
https://kidneytreatment.site/troponin-t-kidney-failure
DiVA - Search resultDiVA - Search result
Background: Most patients with chronic heart failure have detectable troponin concentrations when evaluated by high-sensitivity assays. The prognostic relevance of this finding has not been clearly established so far. We aimed to assess high-sensitivity troponin assay for risk stratification in chronic heart failure through a meta-analysis approach.. Methods: Medline, EMBASE, Cochrane Library, and Scopus were searched in April 2017 by 2 independent authors. The terms were troponin AND heart failure OR cardiac failure OR cardiac dysfunction OR cardiac insufficiency OR left ventricular dysfunction. Inclusion criteria were English language, clinical stability, use of a high-sensitivity troponin assay, follow-up studies, and availability of individual patient data after request to authors. Data retrieved from articles and provided by authors were used in agreement with the PRISMA statement. The end points were all-cause death, cardiovascular death, and hospitalization for cardiovascular ...
http://uu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22journalId%22%3A%228533%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
The Role of Admission Troponin T - Love Life
The Role of Admission Troponin T. Evangelos Giannitsis, Stephanie Lehrke, Uwe K. H. Wiegand, Volkhard Kurowski, Margit Müller-Bardorff, Britta Weidtmann, Gert Richardt, and Hugo A. Katus. Initially published24 Oct 2000https://doi.org/10.1161/01.CIR.102.17.2038Circulation. 2000;102:2038-2044. Unique. Foundation-Cardiac troponin T (cTnT) heights on affirmation demonstrate a high-hazard subgroup of patients with ST-fragment rise intense myocardial localized necrosis (AMI). This finding has been credited to less successful reperfusion after thrombolytic treatment. The point of this examination was to decide the function of confirmation cTnT on the viability of percutaneous coronary intercessions (PCIs) in sub-par AMI.. Techniques and Results-One hundred 59 back to back patients with second rate ST-portion AMI were selected and followed up for a mean of 448 days. Patients were separated by cTnT on confirmation. A cTnT ≥0.1 μg/L was found in 58% of patients. These patients had longer time ...
https://hardrain1.com/the-role-of-admission-troponin-t/
Most recent papers with the keyword Map ais | Read by QxMDMost recent papers with the keyword Map ais | Read by QxMD
OBJECTIVE: Elevated levels of cardiac troponin, and especially their relative changes over time, indicate acute myocardial injury. They are also frequently observed after acute ischemic stroke (AIS), indicating poor functional outcome and increased mortality. However, recent evidence showed that, in most AIS patients, myocardial injury is not caused by coronary ischemia. Instead, stroke lesion location has been suggested to precipitate myocardial injury. METHODS: Voxel-based lesion-symptom mapping (VLSM) was used in 299 patients who had a magnetic resonance imaging-confirmed acute ischemic stroke within the anterior circulation and a high-sensitivity cardiac troponin T (hs-cTnT) acquired on the day of admission ...
https://www.readbyqxmd.com/keyword/120122
Troponin and the J-Curve of Diastolic Blood Pressure | JACC: Journal of the American College of CardiologyTroponin and the J-Curve of Diastolic Blood Pressure | JACC: Journal of the American College of Cardiology
In this issue of the Journal, McEvoy et al. (5) present an insightful analysis of 11,565 subjects from the ARIC (Atherosclerosis Risk In Communities) cohort. Investigating the association between high-sensitivity cardiac troponin-T (hs-cTnT) levels and DBP, they found that compared with people with DBP of 80 to 89 mm Hg, those with a DBP of 60 to 69 mm Hg had higher prevalence of baseline hs-cTnT ≥14 ng/l. Those with DBP ,60 mm Hg had an even higher prevalence. These BP levels were additionally associated with greater increases in hs-cTnT levels over 6 years of follow-up. The hypothesis suggested by these associations is that perhaps low DBP is causing ongoing subclinical myocardial damage that leads to chronic troponin elevation. This finding could provide a mechanistic link that explains why other observational analyses have found an association between low DBP and adverse cardiac outcomes.. McEvoy et al. (5) take their analysis even deeper by evaluating associations with clinical events. ...
http://www.onlinejacc.org/content/68/16/1723
Combining Biomarkers and Imaging for Short-Term Assessment of Cardiovascular Disease Risk in Apparently Healthy AdultsCombining Biomarkers and Imaging for Short-Term Assessment of Cardiovascular Disease Risk in Apparently Healthy Adults
Background Current strategies for cardiovascular disease (CVD) risk assessment focus on 10-year or longer timeframes. Shorter-term CVD risk is also clinically relevant, particularly for high-risk occupations, but is under-investigated. Methods and Results We pooled data from participants in the ARIC (Atherosclerosis Risk in Communities study), MESA (Multi-Ethnic Study of Atherosclerosis), and DHS (Dallas Heart Study), free from CVD at baseline (N=16 581). Measurements included N-terminal pro-B-type natriuretic peptide (,100 pg/mL prospectively defined as abnormal); high-sensitivity cardiac troponin T (abnormal ,5 ng/L); high-sensitivity C-reactive protein (abnormal ,3 mg/L); left ventricular hypertrophy by ECG (abnormal if present); carotid intima-media thickness, and plaque (abnormal ,75th percentile for age and sex or presence of plaque); and coronary artery calcium (abnormal ,10 Agatston U). Each abnormal test result except left ventricular hypertrophy by ECG was independently associated with ...
https://archive.hshsl.umaryland.edu/handle/10713/13556
Browse In Sport and Exercise Science/Kinesiology, At the Barre, Battement Tendu Relevé , Physical Education and Coaching |...Browse In Sport and Exercise Science/Kinesiology, At the Barre, Battement Tendu Relevé , Physical Education and Coaching |...
Purpose: Plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T levels show a transient increase after marathon running. The aim of this study was to investigate whether running duration influences the patterns of changes in cardiac biomarkers. Methods: Twenty participants with fast and slow finishing times were included in the study. Blood samples were taken before the marathon race, immediately after, and 24 hours after the race. Samples were analyzed for NT-proBNP and cardiac troponin T concentration. Furthermore, a complete blood cell count was performed. Results: After the marathon race, the fast and slow runners showed similar changes of NT-proBNP and cardiac troponin T (ie, a transient increase). Curve estimation regression analysis showed a curvilinear relationship (quadratic model) between running times and NT-proBNP increments immediately after the race, with less of an increase in the very fast and the very slow runners (r2 = .359, P = .023). NT-proBNP ...
https://journals.humankinetics.com/browse?access=all&page=16&pageSize=10&sort=datedescending&t_0=SportExSciKin&t_1=C24&t_2=S51&t_3=PhysEdCoach
Prospective study of the role of cardiac troponin T in patients admitted with unstable angina | The BMJ
We conducted a single centre blinded study with follow up of patients admitted to a hospital coronary care unit with chest pain. Management decisions were based on clinical, electrocardiographic, and routine biochemical marker results (daily serum creatine kinase, aspartate transaminase, and hydroxybutyrate dehydrogenase activities). An additional sample was taken 12-24 hours after admission, when the cardiac troponin T concentration is at its most efficient for diagnosing myocardial damage in these patients.11 All management decisions were made without knowledge of the patients troponin T status.. Full clinical details of each patient were recorded on a form. Follow up for cardiac events was by examination of hospital records, necropsy reports when available and death certificates, questionnaires, and telephone contact when required. Survival status and cause of death were established for all patients. Cause of death was classified according to American Heart Association ...
https://www.bmj.com/content/313/7052/262?ijkey=7854f590d7fe50fbb7296570becc037f613665fb&keytype2=tf_ipsecsha
High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study<...
TY - JOUR. T1 - High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study. AU - High-STEACS investigators. AU - Shah, Anoop S V. AU - Anand, Atul. AU - Sandoval, Yader. AU - Lee, Kuan Ken. AU - Smith, Stephen W. AU - Adamson, Philip D. AU - Chapman, Andrew R.. AU - Langdon, Timothy. AU - Sandeman, Dennis. AU - Vaswani, Amar. AU - Strachan, Fiona E.. AU - Ferry, Amy. AU - Stirzaker, Alexandra G. AU - Reid, Alan. AU - Gray, Alasdair J. AU - Collinson, Paul O. AU - McAllister, David A. AU - Apple, Fred S. AU - Newby, David E. AU - Mills, Nicholas L. N1 - Date of Acceptance: 15/09/2015. PY - 2015/12/19. Y1 - 2015/12/19. N2 - Background: Suspected acute coronary syndrome is the commonest reason for emergency admission to hospital and is a large burden on health-care resources. Strategies to identify low-risk patients suitable for immediate discharge would have major benefits.Methods: We did a prospective cohort study of 6304 consecutively ...
https://www.research.ed.ac.uk/en/publications/high-sensitivity-cardiac-troponin-i-at-presentation-in-patients-w
Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of...Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of...
We investigated the effect of 7 Hypertrophic Cardiomyopathy (HCM)-causing mutations in troponin T (TnT) on troponin function in thin filaments reconstituted with actin and human cardiac tropomyosin. We used the quantitative in vitro motility assay to study Ca(2+)-regulation of unloaded movement and its modulation by troponin I phosphorylation. Troponin from a patient with the K280N TnT mutation showed no difference in Ca(2+)-sensitivity when compared with donor heart troponin and the Ca(2+)-sensitivity was also independent of the troponin I phosphorylation level (uncoupled). The recombinant K280N TnT mutation increased Ca(2+)-sensitivity 1.7-fold and was also uncoupled. The R92Q TnT mutation in troponin from transgenic mouse increased Ca(2+)-sensitivity and was also completely uncoupled. Five TnT mutations (Δ14, Δ28 + 7, ΔE160, S179F and K273E) studied in recombinant troponin increased Ca(2+)-sensitivity and were all fully uncoupled. Thus, for HCM-causing mutations in TnT, Ca(2+)-sensitisation
https://www.rdm.ox.ac.uk/publications/613997
May 2016-Laboratories and hospitals in the U.S. continue to look forward to high-sensitivity troponin assays. | DPC LebanonMay 2016-Laboratories and hospitals in the U.S. continue to look forward to high-sensitivity troponin assays. | DPC Lebanon
Judd E. Hollander, MD, says all hes heard for the past five years is that an assay will be out at the end of the year. And once you get halfway through the year, it will be out next year, says Dr. Hollander, chair of the Department of Emergency Medicine and associate dean of strategic health initiatives at Sidney Kimmel Medical College of Thomas Jefferson University.. Robert Christenson, PhD, DABCC, professor of pathology at the University of Maryland School of Medicine, sees the odds as good that the FDA will clear one such assay this year. He predicts it will be a Roche or an Abbott assay.. Agim Beshiri, MD, Abbotts senior medical director of global medical and scientific affairs for diagnostics, says, The requirements for U.S. regulatory approval for any troponin test are very high, and the complexity is enhanced with high-sensitivity troponin methods. It is not possible to predict when these tests will become available.. Dr. deFilippi. The FDA appears to have two concerns, says ...
http://www.dpcleb.com/news/view/77
Is there excessive troponin testing in clinical practice? Evidence from emergency medical admissions | European Federation of...
Troponin assays are a relatively common laboratory diagnostic request in emergency medical admissions. Following cardiac injury these macromolecules diffuse into the cardiac interstitium with subsequent detection in the peripheral circulation. We have previously shown that a clinical decision to request high-sensitivity cardiac troponin T (hscTnT) was a prognostic marker and semi-quantitative mortality predictor in unselected emergency medical admissions [1]. Cardiac-specific troponins are useful because they convey prognostic information that can influence therapeutic decisions, [2] not alone for the diagnosis of acute coronary syndromes [3], but also in non-cardiac presentations [4-17].. ...
https://efim.org/education/ejim/may-2021/there-excessive-troponin-testing-clinical-practice-evidence-emergency
Troponin T expression in trout red muscle correlates with muscle activation | Journal of Experimental BiologyTroponin T expression in trout red muscle correlates with muscle activation | Journal of Experimental Biology
A number of studies have demonstrated a role for troponin T in the modulation of muscle activation, particularly in fishes. Cod Gadus morhua show longitudinal variation in the activation of their white muscle (Davies et al., 1995). Thys et al. (1998) demonstrated that this shift in muscle contractile properties correlates with a longitudinal pattern of expression of two isoforms of TnT. Similarly, Thys et al. (2001) showed a significant rostral-caudal shift in both muscle activation and TnT expression in the white muscle of largemouth bass. In both cod and bass, the anterior muscle is kinetically faster and expresses relatively greater amounts of an isoform of TnT that migrates faster on PAGE gels. (TnT-2; Thys et al., 1998, 2002). For both white (cod and bass) and red (rainbow and brook trout) muscle in fishes, the kinetically faster isoform of TnT appears to be the physically smaller isoform found in each type of muscle. Other fish, such as saithe Pollachius virens (Altringham et al., 1993), ...
http://jeb.biologists.org/content/208/2/409
Cardiac troponin T in children with acute rheumatic carditis.
The existence of cardiac damage in active rheumatic carditis patients is unknown, especially in those without pericarditis. The aim of this study was to determine cardiac myocyte damage using cardiac troponin T (cTnT) measurements in active rheumatic
http://www.biomedsearch.com/nih/Cardiac-Troponin-T-in-Children/20957477.html
Troponins as cardiac markers | HyTest Troponins
Cardiac conditions. Certain subtypes of troponin (cardiac troponin I and T) are very sensitive and specific indicators of damage to the heart muscle (myocardium). They are measured in the blood to differentiate between unstable angina and myocardial infarction (heart attack) in patients with chest pain or acute coronary syndrome. A patient who had suffered from a myocardial infarction would have an area of damaged heart muscle and so would have elevated cardiac troponin levels in the blood. This can also occur in patients with coronary vasospasm.. It is important to note that cardiac troponins are a marker of all heart muscle damage, not just myocardial infarction. Other conditions that directly or indirectly lead to heart muscle damage can also increase troponin levels. Severe tachycardia (for example due to supraventricular tachycardia) in an individual with normal coronary arteries can also lead to increased troponins for example, presumably due to increased oxygen demand and inadequate ...
http://troponins.com/general_information/troponins-cardiac-markers-0
High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: The...
TY - JOUR. T1 - High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation. T2 - The MORGAM Biomarker Project Scottish Cohort. AU - Zeller, Tanja. AU - Tunstall-Pedoe, Hugh. AU - Saarela, Olli. AU - Ojeda, Francisco. AU - Schnabel, Renate B.. AU - Tuovinen, Tarja. AU - Woodward, Mark. AU - Struthers, Allan. AU - Hughes, Maria. AU - Kee, Frank. AU - Salomaa, Veikko. AU - Kuulasmaa, Kari. AU - Blankenberg, Stefan. PY - 2014/2/1. Y1 - 2014/2/1. N2 - Our aim was to test the prediction and clinical applicability of high-sensitivity assayed troponin I for incident cardiovascular events in a general middle-aged European population. Methods and results High-sensitivity assayed troponin Iwasmeasured in the Scottish HeartHealth ExtendedCohort (n = 15 340) with 2171 cardiovascular events (including acute coronary heart disease and probable ischaemic strokes), 714 coronary deaths (25% of all deaths),1980myocardial infarctions, and797strokesof all ...
https://jhu.pure.elsevier.com/en/publications/high-population-prevalence-of-cardiac-troponin-i-measured-by-a-hi-4
Ceruloplasmin and Heart Failure in the Atherosclerosis Risk in Communities StudyClinical Perspective | Circulation: Heart...Ceruloplasmin and Heart Failure in the Atherosclerosis Risk in Communities StudyClinical Perspective | Circulation: Heart...
Methods and Results-Cp was measured at ARIC visit 4 (1996-1998). We studied 9240 individuals without HF or CVD at ARIC visit 4 and followed them for a mean of 10.5 years. Genome-wide association study was performed to identify genetic determinants of Cp levels and evaluate their association with incident HF in ARIC participants. Cp levels (mean±SD) were higher in women versus men (335±79 versus 258±44 mg/L; P,0.0001), women on versus not on hormone-replacement therapy (398±89 versus 291±60 mg/L; P,0.0001), and African Americans versus whites (299±63 versus 293±74 mg/L; P=0.0005). After adjusting for traditional risk factors, high-sensitivity C-reactive protein, N-terminal pro-B-type natriuretic peptide, and high-sensitivity cardiac troponin T, higher levels of Cp were associated with HF (hazard ratio, 1.44; 95% confidence interval, 1.13-1.83) and mortality (hazard ratio, 1.38; 95% confidence interval, 1.11-1.63). A locus on the ceruloplasmin gene on chromosome 3 was significantly ...
http://circheartfailure.ahajournals.org/content/6/5/936.short?rss=1
High-sensitivity troponin i: Two-hour evaluation for acute myocardial by Richard M. Nowak, Gordon Jacobsen et al.High-sensitivity troponin i: Two-hour evaluation for acute myocardial by Richard M. Nowak, Gordon Jacobsen et al.
Background: High sensitivity cardiac troponin I (hs-cTnI) assays are being approved for use in the United States (US). Our objective was to determine the efficacy of a 2 hour acute myocardial infarction (AMI) rule-out/rule-in European derived hs-cTnI algorithm when applied to patients in the US when the second sample was drawn 2-3 hours later in the High Sensitivity Cardiac Troponin I in the US (HIGH-US) study. Methods: Adults presenting with any suspicion for AMI were included. Patients with STEMI were excluded. Baseline and 2-3 hour plasma samples were analyzed in a core laboratory (University of Maryland) using the Siemens Atellica hs-cTnI assay (99th % 45.0 ng/L). AMI was independently adjudicated using all 30 day clinical materials available. Results: 2505 patients were enrolled with 1916 having complete data for the 2-3 hour algorithm analyses. Subjects had a mean age of 56.7 ± 12.9 years and 1419 (56.5%) were males Past medical history included hypertension in 1730 (69.1%), coronary artery
https://scholarlycommons.henryford.com/publichealthsciences_mtgabstracts/11/
Coronary angiographic findings and troponin T in patients with unstable angina pectoris.
This study sought to identify differences in coronary anatomic pathology in patients with unstable angina and elevated versus nonelevated serum troponin T values. Previous studies have shown a worse prognosis in unstable angina patients with elevated
http://www.biomedsearch.com/nih/Coronary-angiographic-findings-troponin-T/10758918.html
troponin | Master Of Medicinetroponin | Master Of Medicine
Image via Wikipedia Troponin Troponin is a complex of three regulatory proteins. Troponin T-Attaches troponin complex to Tropomyosin Troponin I-Binds troponin complex to actin Troponin C-Calcium binding troponin Tropomyosin Covers the sites where myosin heads bind actin. Troponin-Tropomyosin complex inhibits …. Read more ». ...
http://masterofmedicine.com/tag/troponin/
Prognostic implications of elevated troponin in patients with suspected acute coronary syndrome but no critical epicardial...Prognostic implications of elevated troponin in patients with suspected acute coronary syndrome but no critical epicardial...
We have previously demonstrated the strong prognostic value of cardiac troponin in patients with high clinical suspicion for non-ST-segment elevation ACS (14). The present study demonstrates that, in the important group of patients presenting with symptoms of ACS who were later found to not have angiographically significant CAD, the presence of an elevated troponin is also associated with an adverse prognosis. This finding challenges the idea that these are false-positive troponin results and that these patients may be regarded as low-risk for subsequent cardiovascular events. Elevation of troponin in these patients may result from coronary atherothrombosis not evident using standard angiography or from other ischemic and non-ischemic mechanisms.. In the current study, 6% of patients who satisfied clinical criteria for ACS and had elevated troponin early after presentation were found not to have significant angiographic coronary stenosis. Despite the absence of significant coronary stenosis, ...
http://www.onlinejacc.org/content/45/1/19
HsTnT in Stable Coronary Artery Disease - Full Text View - ClinicalTrials.govHsTnT in Stable Coronary Artery Disease - Full Text View - ClinicalTrials.gov
Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality worldwide. Life threatening manifestations such as acute myocardial infarction (AMI) and sudden cardiac death are the most important causes of death in many countries. Cardiac troponin is a biomarker with a high specificity for cardiac necrosis and is recommended for diagnosis of acute myocardial infarction by the Universal definition of myocardial infarction. Since a new generation of high-sensitivity cardiac troponin assays has become commercially available a few years ago, myocardial infarction can be detected earlier and even small AMIs, that were classified as unstable angina pectoris (UAP) with the less sensitive assays, are detectable now. On the other side, more patients with acute or chronic myocardial damage not due to AMI are identified now. Thereby, the reason for elevated troponin levels should be sought actively, because high troponin levels were associated with adverse outcome - independent of ...
https://clinicaltrials.gov/show/NCT01954303
Decreased left ventricular ejection fraction in transgenic mice expressing mutant cardiac troponin T-Q<sup>92</sup>,...
TY - JOUR. T1 - Decreased left ventricular ejection fraction in transgenic mice expressing mutant cardiac troponin T-Q92, responsible for hypertrophic cardiomyopathy. AU - Lim, Do Sun. AU - Oberst, Leslie. AU - McCluggage, Meghan. AU - Youker, Keith. AU - Lacy, Jeffrey. AU - DeMayo, Francesco. AU - Entman, Mark L.. AU - Roberts, Robert. AU - Michael, Lloyd H.. AU - Marian, Ali J.. PY - 2000. Y1 - 2000. N2 - The causality of mutant sarcomeric proteins in hypertrophic cardiomyopathy (HCM) is well established. The current emphasis is to elucidate the pathogenesis of HCM in transgenic animal models. We determined the left ventricular ejection fraction (LVEF) in transgenic mice expressing mutant cardiac troponin T (cTnT)-Q92, known to cause HCM in humans. Transgenes were constructed by placing wild-type (R92) or mutant (Q92) full-length human cTnT cDNAs 3 into a 5.5-kb murine [α-myosin heavy chain (MyHC)] promoter injected into fertilized zygotes. Three wild-type and six mutant lines were produced. ...
https://koreauniv.pure.elsevier.com/en/publications/decreased-left-ventricular-ejection-fraction-in-transgenic-mice-e
Ms Jaimi Greenslade - UQ ResearchersMs Jaimi Greenslade - UQ Researchers
Association of high-sensitivity cardiac troponin I concentration with cardiac outcomes in patients with suspected acute coronary syndrome. Chapman, Andrew R., Lee, Kuan Ken, McAllister, David A., Cullen, Louise, Greenslade, Jaimi H., Parsonage, William, Worster, Andrew, Kavsak, Peter A., Blankenberg, Stefan, Neumann, Johannes, Söerensen, Nils A., Westermann, Dirk, Buijs, Madelon M., Verdel, Gerard J. E., Pickering, John W., Than, Martin P., Twerenbold, Raphael, Badertscher, Patrick, Sabti, Zaid, Mueller, Christian, Anand, Atul, Adamson, Philip, Strachan, Fiona E., Ferry, Amy, Sandeman, Dennis, Gray, Alasdair, Body, Richard, Keevil, Brian, Carlton, Edward, Greaves, Kim, Korley, Frederick K., Metkus, Thomas S., Sandoval, Yader, Apple, Fred S., Newby, David E., Shah, Anoop S. V. and Mills, Nicholas L. (2017) Association of high-sensitivity cardiac troponin I concentration with cardiac outcomes in patients with suspected acute coronary syndrome. JAMA - Journal of the American Medical Association, ...
https://researchers.uq.edu.au/researcher/3898
Troponin assay use in the emergency department for management of patients with potential acute coronary syndrome: current use...Troponin assay use in the emergency department for management of patients with potential acute coronary syndrome: current use...
The timing of troponin elevation after an ischemic event is another topic of research, as serial troponin measurements have been found to be an effective tool to detect developing myocardial injury. Initial research on troponins has shown cTnT and cTnI are most commonly elevated 4 to 9 hours after myocardial injury, with a peak at 12 to 24 hours. These enzymes may remain elevated in the blood for 7 to 14 days [3]. Thus, the time from onset of chest pain is crucially important for ED practitioners to discern, as troponin elevations may not be detected with commonly used assays if the insult occurred immediately prior (i.e., less than two hours) to presentation. To account for this discrepancy, practitioners will frequently observe patients who lack the electrocardiographic (ECG) changes indicative of ST-segment myocardial infarctions in addition to having a negative initial troponin. The observation period usually involves repeat physical examinations and telemetry monitoring along with repeat ...
http://ceemjournal.org/journal/view.php?number=69
Repercusión de la elevación de troponina T con valores normales de creatincinasa sobre la función ventricular en los síndromes...Repercusión de la elevación de troponina T con valores normales de creatincinasa sobre la función ventricular en los síndromes...
PIOMBO, Alfredo C et al. Clinical Significance of High Troponin T with Normal Creatine Kinase Levels on Ventricular Function in Acute Coronary SyndromesClinical Significance of High Troponin T with Normal Creatine Kinase Levels on Ventricular Function in Acute Coronary Syndromes Background. Rev. argent. cardiol. [online]. 2012, vol.80, n.2, pp. 145-150. ISSN 1850-3748.. The role of elevated troponins to predict changes on ventricular function in patients with high creatine kinase (CK) levels has been well established; yet, little is known about the clinical significance of high troponin levels with normal CK levels. Objectives To analyze the relation between Troponin T (TnT) levels and global and regional left ventricular function in patients with acute coronary syndromes (ACS) with normal CK and CK-MB levels. Material and Methods We included patients admitted to the coronary care unit due to ACS within 48 hours from symptoms onset with elevated TnT levels measured by quantitative determination ...
http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S1850-37482012000200008&lng=en&nrm=iso&tlng=en
Cardiac troponin I in pediatrics: Normal values and potential use in the assessment of cardiac injury<...
TY - JOUR. T1 - Cardiac troponin I in pediatrics. T2 - Normal values and potential use in the assessment of cardiac injury. AU - Hirsch, R.. AU - Landt, Y.. AU - Porter, S.. AU - Canter, C. E.. AU - Jaffe, A. S.. AU - Ladenson, J. H.. AU - Grant, J. W.. AU - Landt, M.. PY - 1997/1/1. Y1 - 1997/1/1. N2 - Objective: To establish normal values and determine the impact of congenital or acquired heart disease on serum cardiac troponin I (cTnl). Methods: Concentrations of cTnl were measured in two groups of children. Group A represented ambulatory pediatric patients with no apparent cardiac disease (n = 120) and patients in stable condition with known congenital or acquired cardiac abnormalities (n = 96); group B was composed of patients admitted to intensive care units with normal echocardiograms (n = 16), with abnormal echocardiograms (n = 36), and those with blunt chest trauma who were thought to have cardiac contusions (n = 7). Results: The cTnl concentrations were generally less than 2.0 ng/ml in ...
https://mayoclinic.pure.elsevier.com/en/publications/cardiac-troponin-i-in-pediatrics-normal-values-and-potential-use-
1998 - Creatine kinase-MB, cardiac troponin T, and myoglobin levels identified failed reperfusion after thrombolysis...1998 - Creatine kinase-MB, cardiac troponin T, and myoglobin levels identified failed reperfusion after thrombolysis...
The results of the study by Stewart and colleagues confirm previous findings showing that successful coronary reperfusion leads to an accelerated increase in the levels of plasma markers of myocardial injury in patients treated with thrombolytic therapy for MI (1-3). Changes in the level of myoglobin have been found in almost all previous studies to be useful in detecting coronary reperfusion but may lack specificity because this marker is not cardiac-specific. Rapid increases in CKMB, MB isoforms, and troponin may offer enhanced specificity but may be less sensitive because early changes in levels of these compounds are less marked than those of myoglobin. Differences also exist in the performance of the available assays for these markers. This is important for development of clinical criteria for failure of reperfusion. Nonetheless, available data suggest that using ratios of 60- and 90-minute levels to the initial levels of some of these markers is reasonably accurate for assessing the ...
http://www.acpjc.org/Content/129/3/issue/ACPJC-1998-129-3-071.htm
TROPONIN and TROPONIN CARDIAC I and T: function, metabolism and normal values - ExamievaloriTROPONIN and TROPONIN CARDIAC I and T: function, metabolism and normal values - Examievalori
When measured with the old assays, elevated troponin levels could be detected between 6 and 12 hours after the myocardial damage event, peaking at 24 hours followed by a gradual decline after two weeks.. In recent years there has been the introduction of a new type of troponin, troponin to high sensitivity, with different sensitivity and specificity, which made it possible to overcome the large limit of classical troponins of being detectable in the blood only several hours after the ischemic event and which improved the diagnostic accuracy, being able to diagnose subendocardial or transmural infarction with two samples veins performed just 3 hours apart from each other.. It was a remarkable one increase of the sensitivity for IMA (from 63.7% to 90.7%), compared to a slight reduction of the specificity (from 97.2% to 90.7%). However, the tissue specificity of troponin hs for damage to cardiomyocytes, which is always very high, must always be distinguished from clinical specificity for AMI, which ...
https://www.esamievalori.com/en/troponin-it-cardiac-troponins-high-low-normal-values/
A Multi-Stage decision support Algorithm to Rule-Out patientswith suspected Acute Myocardial Infarction (AMI)<...A Multi-Stage decision support Algorithm to Rule-Out patientswith suspected Acute Myocardial Infarction (AMI)<...
TY - GEN. T1 - A Multi-Stage decision support Algorithm to Rule-Out patientswith suspected Acute Myocardial Infarction (AMI). AU - Navarro-Paredes, Cesar. AU - Shand, James A. AU - McEneaney, David. AU - McLaughlin, James. PY - 2016/5/27. Y1 - 2016/5/27. N2 - Objective: Provide a multi-stage rule-out algorithm to stratify patients admitted to the Emergency Room (ER) with chest pain of presumed ischemic origin. The aim is to keep at-risk patients in the ER providing a proper care while minimizing overcrowding. The algorithm uses data from biomarkers -heart-type fatty acid-binding protein (H-FABP), high sensitivity cardiac troponin T (hs-cTnT) measured at different times (presentation, 1, 2, 3, 6, 12 and 24 hours) together with ECG at presentation.Methods: Data in a randomly selected training set of 296 patients were retrospectively analysed. 182 cases comprised a test set. STEMI were not considered since biomarkers are not routinely measured for these cases. H-FABP and hs-cTnT were statistically ...
https://pure.ulster.ac.uk/en/publications/a-multi-stage-decision-support-algorithm-to-rule-out-patientswith-3
Plus itPlus it
The IFCC Committee on Clinical Applications of Cardiac Bio-Markers (C-CB) has directives and initiatives focused on providing evidence-based educational resources to aid and improve understanding around key analytical and clinical aspects of cardiac biomarkers used in clinical practice and the research setting. As a task force, we have previously published position statements and recommendations focused on use and analytical aspects of high-sensitivity cardiac troponin assays. The current educational document is the first from the C-CB highlighting important biochemical, analytical, and clinical aspects as they relate to the natriuretic peptides (NPs), including B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), with a focus on heart failure. ...
http://clinchem.aaccjnls.org/content/65/10/1221
Frontiers | The Importance of Intrinsically Disordered Segments of Cardiac Troponin in Modulating Function by Phosphorylation...Frontiers | The Importance of Intrinsically Disordered Segments of Cardiac Troponin in Modulating Function by Phosphorylation...
Troponin plays a central role in regulation of muscle contraction. It is the Ca2+ switch of striated muscles including the heart and in the cardiac muscle is physiologically modulated by PKA-dependent phosphorylation at Ser22 and 23. Many cardiomyopathy-related mutations affect Ca2+ regulation and/or disrupt the relationship between Ca2+ binding and phosphorylation. Unlike the mechanism of heart activation, the modulation of Ca2+-sensitivity by phosphorylation of the cardiac specific N-terminal segment of TnI (1-30) is structurally subtle and has proven hard to investigate. The crystal structure of cardiac troponin describes only the relatively stable core of the molecule and the crucial mobile parts of the molecule are missing including TnI C terminal region, TnI (1-30), TnI (134-149) (inhibitory peptide) and the C-terminal 28 amino acids of TnT that are intrinsically disordered.Recent studies over the years have been performed to answer this matter by building structural models of cardiac troponin
https://www.frontiersin.org/articles/10.3389/fphys.2016.00508/full
Chest-Pain Patients and High-Sensitivity Troponin Tests: the New Frontier - ACEP NowChest-Pain Patients and High-Sensitivity Troponin Tests: the New Frontier - ACEP Now
ACEP Now offers real-time clinical news, news from the American College of Emergency Physicians, and news on practice trends and health care reform for the emergency medicine physician. ACEP Now is an official publication of the American College of Emergency Physicians.
https://www.acepnow.com/article/chest-pain-patients-high-sensitivity-troponin-tests-new-frontier/
High cardiac troponin levels may predict mortality in community-acquired pneumonia - The Clinical AdvisorHigh cardiac troponin levels may predict mortality in community-acquired pneumonia - The Clinical Advisor
Elevated cardiac troponin levels were highly predictive of both in-hospital and long-term mortality in patients admitted for CAP.
https://www.clinicaladvisor.com/infectious-diseases-information-center/high-cardiac-troponin-levels-may-predict-mortality-in-cap/article/647846/
Causes Of Elevated Troponin And Its Connection To Kidney DiseaseCauses Of Elevated Troponin And Its Connection To Kidney Disease
Elevated troponin in kidney disease. Troponin can be elevated in acute and chronic kidney disease. Here are some reasons why troponin can be elevated.
https://www.healingheartdiseasenaturally.com/elevated-troponin-in-kidney-disease/
Cardiac Troponins And The Cardiac Myocyte - 1034 Words | BartlebyCardiac Troponins And The Cardiac Myocyte - 1034 Words | Bartleby
Free Essay: Cardiac Troponins are specific to the cardiac myocyte and have central role in diagnosing ACS. They are found to be specific and sensitive, in...
https://www.bartleby.com/essay/Cardiac-Troponins-And-The-Cardiac-Myocyte-PKKXCJBW3FV8X
NFAT primes the human RORC locus for RORγt expression in CD4 + T cells | Nature CommunicationsNFAT primes the human RORC locus for RORγt expression in CD4 + T cells | Nature Communications
T helper 17 (Th17) cells have crucial functions in mucosal immunity and the pathogenesis of several chronic inflammatory diseases. The lineage-specific transcription factor, RORγt, encoded by the RORC gene modulates Th17 polarization and function, as well as thymocyte development. Here we define several regulatory elements at the human RORC locus in thymocytes and peripheral CD4+ T lymphocytes, with CRISPR/Cas9-guided deletion of these genomic segments supporting their role in RORγt expression. Mechanistically, T cell receptor stimulation induces cyclosporine A-sensitive histone modifications and P300/CBP acetylase recruitment at these elements in activated CD4+ T cells. Meanwhile, NFAT proteins bind to these regulatory elements and activate RORγt transcription in cooperation with NF-kB. Our data thus demonstrate that NFAT specifically regulate RORγt expression by binding to the RORC locus and promoting its permissive conformation. The master transcription factor RORγt, encoded by the RORC gene,
https://www.nature.com/articles/s41467-019-12680-x?error=cookies_not_supported&code=09c4c89e-2208-4107-b66f-63aaf04ea7b0
Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy...Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy...
RATIONALE: Subcellular Ca2+ indicators have yet to be developed for the myofilament where disease mutation or small molecules may alter contractility through myofilament Ca2+ sensitivity. Here, we develop and characterize genetically encoded Ca2+ indicators restricted to the myofilament to directly visualize Ca2+ changes in the sarcomere. OBJECTIVE: To produce and validate myofilament-restricted Ca2+ imaging probes in an adenoviral transduction adult cardiomyocyte model using drugs that alter myofilament function (MYK-461, omecamtiv mecarbil, and levosimendan) or following cotransduction of 2 established hypertrophic cardiomyopathy disease-causing mutants (cTnT [Troponin T] R92Q and cTnI [Troponin I] R145G) that alter myofilament Ca2+ handling. METHODS AND RESULTS: When expressed in adult ventricular cardiomyocytes RGECO-TnT (Troponin T)/TnI (Troponin I) sensors localize correctly to the sarcomere without contractile impairment. Both sensors report cyclical changes in fluorescence in paced
https://www.rdm.ox.ac.uk/publications/969431
Ingebjørg Seljeflot - Institute of Clinical MedicineIngebjørg Seljeflot - Institute of Clinical Medicine
Horjen, Anja Wiedswang; Ulimoen, Sara Reinvik; Norseth, Jon; Svendsen, Jesper Hastrup; Smith, Pål; Arnesen, Harald; Seljeflot, Ingebjørg & Tveit, Arnljot (2018). High-sensitivity troponine I in persistent atrial fibrillation - relation to NT-proBNP and markers of inflammation and haemostasis. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 78(5), s 386- 392 . doi: 10.1080/00365513.2018.1481224 Show summary Purpose: As cardiac troponins emerge as prognostic markers in atrial fibrillation (AF), it is important to identify mechanisms initiating and perpetuating cardiac troponin release, including its relations to other circulating biomarkers, in AF populations. We studied associations between high-sensitivity troponin I (hs-TnI) and markers representing myocardial wall tension, inflammation and haemostasis in persistent AF. Methods: In a double blind, placebo-controlled study, 171 patients referred for electrical cardioversion for persistent AF were randomised to ...
https://www.med.uio.no/klinmed/english/people/aca/ingebse/index.html
What are other reasons other than heart attack for increased level of troponin - New Doctor InsightsWhat are other reasons other than heart attack for increased level of troponin - New Doctor Insights
What are other reasons other than heart attack for increased level of troponin - What are other reasons other than heart attack for increased level of troponin? Any heart problem. Troponin is an enzyme released by damaged heart muscle. While the major cause is a heart attack, and large increases are usually due to this, almost any condition affecting the heart can cause small increases. Viral infections of the heart, pulmonary embolus or medial procedures such as angioplasty often result in increases of troponin.
https://www.healthtap.com/topics/what-are-other-reasons-other-than-heart-attack-for-increased-level-of-troponin
Cost-effectiveness of cardiac biomarkers as screening test in acute chest pain<...Cost-effectiveness of cardiac biomarkers as screening test in acute chest pain<...
TY - JOUR. T1 - Cost-effectiveness of cardiac biomarkers as screening test in acute chest pain. AU - Shams-Vahdati, Samad. AU - Vand-Rajavpour, Zahra. AU - Paknezhad, Seyed-Pouya. AU - Piri, Reza. AU - Moghaddasi-Ghezeljeh, Elnaz. AU - Mirabolfathi, Saba. AU - Naghavi-Behzad, Mohammad. PY - 2014. Y1 - 2014. N2 - INTRODUCTION: Acute chest pain is an important and frequently occurring symptom in patients. Chest pain is often a sign of ischemic heart disease. Associated findings of electrocardiograph (ECG) are rather heterogeneous, and traditional cardiac biomarkers such as Creatine Kinase-MB (CK-MB) suffer from low cardiac specificity and sensitivity. In this study cost effectiveness of cardiac biomarkers single quantitative measurement was examined.METHODS: The present descriptive-analytic study conducted on patients who were asked for troponin I and CK-MB. All patients who referred to Emergency unit of Tabriz Imam Reza educational-medical center during January 2012 to July the 2013 were included ...
https://portal.findresearcher.sdu.dk/da/publications/cost-effectiveness-of-cardiac-biomarkers-as-screening-test-in-acu
Troponin T, creatine kinase MB mass, and creatine kinase MB isoform ratio in the detection of myocardial damage during non...Troponin T, creatine kinase MB mass, and creatine kinase MB isoform ratio in the detection of myocardial damage during non...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/9209933?dopt=Abstract
What is Troponin? - HealthMatters.io - Lab results explainedWhat is Troponin? - HealthMatters.io - Lab results explained
Troponin proteins are released when the heart muscle has been damaged, such as occurs with a heart attack. The more damage there is to the heart, the greater the amount of troponin T and I there will be in the blood. The most common reason to perform this test is to see if a heart…
https://blog.healthmatters.io/2018/08/03/what-is-troponin/
Troponin Levels - The Heart Attack Blood Test myheart.netTroponin Levels - The Heart Attack Blood Test myheart.net
Troponin levels Article by an interventional cardiologist describing the usefulness of measuring blood troponin levels in investigating heart disease
https://myheart.net/articles/troponin-levels-the-heart-attack-blood-test/?replytocom=23282
Troponin Levels - The Heart Attack Blood Test myheart.netTroponin Levels - The Heart Attack Blood Test myheart.net
Troponin levels Article by an interventional cardiologist describing the usefulness of measuring blood troponin levels in investigating heart disease
https://myheart.net/articles/troponin-levels-the-heart-attack-blood-test/?replytocom=21071
Troponin elevation | Radiology Reference Article | Radiopaedia.orgTroponin elevation | Radiology Reference Article | Radiopaedia.org
Troponin elevation can occur from a number causes although there is no imaging involved, it is useful for the radiologist to have a basic understanding of their causes (especially when interpreting imaging findings associated with troponin elevat...
https://radiopaedia.org/articles/troponin-elevation-1
ST2 cardiac biomarker - WikipediaST2 cardiac biomarker - Wikipedia
The ST2 cardiac biomarker is a protein biomarker of cardiac stress encoded by the IL1RL1 gene. ST2 signals the presence and severity of adverse cardiac remodeling and tissue fibrosis, which occurs in response to myocardial infarction, acute coronary syndrome, or worsening heart failure. ST2 provides prognostic information that is independent of other cardiac biomarkers such as BNP, NT-proBNP, highly sensitive troponin, GDF-15, and galectin-3. One study indicated that discrimination is independent of age, body mass index, history of heart failure, anemia and impaired renal failure or sex. ST2 is a member of the interleukin 1 receptor family. The ST2 protein has two isoforms and is directly implicated in the progression of cardiac disease: a soluble form (referred to as soluble ST2 or sST2) and a membrane-bound receptor form (referred to as the ST2 receptor or ST2L). When the myocardium is stretched, the ST2 gene is upregulated, increasing the concentration of circulating soluble ST2. The ligand ...
https://en.wikipedia.org/wiki/ST2_cardiac_biomarker
What causes elevated troponin? | Reference.comWhat causes elevated troponin? | Reference.com
Elevated troponin levels can be the result of the heart beating too fast, high blood pressure in the lung arteries, congestive heart failure, inflammation in the heart and cardiomyapothy, states...
https://www.reference.com/health/causes-elevated-troponin-c561713c785139cc
TroponinTroponin
... , or the troponin complex, is a complex of three regulatory proteins (troponin C, troponin I, and troponin T) that are ... Calcium-binding protein Troponin C Troponin I Troponin T PDB: 1J1E​; Takeda S, Yamashita A, Maeda K, Maeda Y (2003). "Structure ... Troponin is found in both skeletal muscle and cardiac muscle, but the specific versions of troponin differ between types of ... Troponins at eMedicine Gomes, A.V; Potter, J.D.; Szczesna-Cordary, D. (2002). "The role of Troponin in muscle contraction". ...
https://en.wikipedia.org/wiki/Troponin
Troponin TTroponin T
Slow skeletal troponin T1, TNNT1 (19q13.4, 191041) Cardiac troponin T2, TNNT2 (1q32, 191045) Fast skeletal troponin T3, TNNT3 ( ... Troponin T (shortened TnT or TropT) is a part of the troponin complex, which are proteins integral to the contraction of ... Troponin T binds to tropomyosin and helps position it on actin, and together with the rest of the troponin complex, modulates ... Troponin C Troponin I Calcium-binding protein Sliding filament model Jin, Jian-Ping (2016-01-01), Jeon, Kwang W. (ed.), " ...
https://en.wikipedia.org/wiki/Troponin_T
Troponin ITroponin I
Troponin Troponin T Troponin C Sliding filament model Takeda, Soichi; Yamashita, Atsuko; Maeda, Kayo; Maéda, Yuichiro (July ... Troponin I is a cardiac and skeletal muscle protein family. It is a part of the troponin protein complex, where it binds to ... Reductions in troponin I levels proved to reduce the risk of future CVD. - High sensitive troponin I used as a screening tool ... Troponin I prevents myosin from binding to actin in relaxed muscle. When calcium binds to the troponin C, it causes ...
https://en.wikipedia.org/wiki/Troponin_I
Troponin CTroponin C
A8V D145E A31S C84Y E134D Y5H I148V Troponin Troponin T Troponin I Calcium-binding protein Sliding filament model Kalyva A, ... Troponin C is a protein which is part of the troponin complex. It contains four calcium-binding EF hands, although different ... Fast troponin C, TNNC2 (20q12-q13.11, Online Mendelian Inheritance in Man (OMIM): 191039) Point mutations can occur in troponin ... The C lobe serves a structural purpose and binds to the N domain of troponin I (TnI). The C lobe can bind either Ca2+ or Mg2+. ...
https://en.wikipedia.org/wiki/Troponin_C
Troponin C type 1Troponin C type 1
Chemical compounds can bind to troponin C to act as troponin activators (calcium sensitizers) or troponin inhibitors (calcium ... and cardiac troponin T (cTnT), whereas cTnC binds to slow skeletal troponin I (ssTnI) and troponin T (ssTnT) in slow-twitch ... Troponin C, also known as TN-C or TnC, is a protein that resides in the troponin complex on actin thin filaments of striated ... Troponin C is encoded by the TNNC1 gene in humans for both cardiac and slow skeletal muscle. Cardiac troponin C (cTnC) is a 161 ...
https://en.wikipedia.org/wiki/Troponin_C_type_1
Troponin C, skeletal muscleTroponin C, skeletal muscle
... is a protein that in humans is encoded by the TNNC2 gene. Troponin (Tn), is a key protein complex ... 1998). "Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution". Proc. Natl. Acad. Sci. U.S.A ... 1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin ... "Entrez Gene: TNNC2 troponin C type 2 (fast)". Romero-Herrera AE, Castillo O, Lehmann H (1977). "Human skeletal muscle proteins ...
https://en.wikipedia.org/wiki/Troponin_C,_skeletal_muscle
A8VA8V
... troponin C which is calcium binding, troponin T that plays the role with tropomyosin, and troponin I which has an inhibitory ... Solaro, R. John; Rosevear, Paul; Kobayashi, Tomoyoshi (April 2008). "The unique functions of cardiac troponin I in the control ... A8V is point mutation on Troponin C (cTNC) that leads to a hypertrophic cardiomyopathy. The coordinated cardiac muscle ... Ohtsuki, Iwao; Morimoto, Sachio (April 2008). "Troponin: Regulatory function and disorders". Biochemical and Biophysical ...
https://en.wikipedia.org/wiki/A8V
TNNT2TNNT2
Cardiac TnT is the largest of the three troponin subunits (cTnT, troponin I (TnI), troponin C (TnC)) on the actin thin filament ... "Dephosphorylation specificities of protein phosphatase for cardiac troponin I, troponin T, and sites within troponin T". ... He X, Liu Y, Sharma V, Dirksen RT, Waugh R, Sheu SS, Min W (Jul 2003). "ASK1 associates with troponin T and induces troponin T ... Noland TA, Raynor RL, Kuo JF (Dec 1989). "Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by ...
https://en.wikipedia.org/wiki/TNNT2
W. Bruce FyeW. Bruce Fye
In 2006, his essay "Troponin trumps common sense", which discussed the appropriate use of the troponin test, drew the attention ... In a reply, he stated "rather than allowing troponin to trump common sense, we should inject more common sense into the process ... "Reply: Troponin Trumps Common Sense" (PDF). Journal of the American College of Cardiology. 48: 2357-2358. 5 December 2006. ... Other noted publications have included his 2006 article titled "Troponin trumps common sense" and "Women Cardiologists: Why so ...
https://en.wikipedia.org/wiki/W._Bruce_Fye
Reference ranges for blood testsReference ranges for blood tests
"Troponins". medscape. Retrieved 2017-07-24. Updated: Jan 14, 2015 Caselli, C.; Cangemi, G.; Masotti, S.; Ragusa, R.; Gennai, I ... In addition, some values, including troponin I and brain natriuretic peptide, are given as the estimated appropriate cutoffs to ... Baum, Hannsjörg; Hinze, Anika; Bartels, Peter; Neumeier, Dieter (2004-12-01). "Reference values for cardiac troponins T and I ... High sensitive troponin I in pediatric age". Clinica Chimica Acta. 458: 68-71. doi:10.1016/j.cca.2016.04.029. ISSN 0009-8981. ...
https://en.wikipedia.org/wiki/Reference_ranges_for_blood_tests
Carryover effectCarryover effect
Troponin...etc.). A small portion of carryover could lead to erroneous results. IUPAC made a recommendation in 1991 for the ... carryover of cardiac High sensitivity Troponin assay would be catastrophic. Haeckel, R. (1991-01-01). "Proposals for the ...
https://en.wikipedia.org/wiki/Carryover_effect
Tropomyosin 3Tropomyosin 3
A novel troponin T-like protein". Hypertension. 11 (6 Pt 2): 620-6. doi:10.1161/01.hyp.11.6.620. PMID 2455687. Coulier F, ...
https://en.wikipedia.org/wiki/Tropomyosin_3
Blunt cardiac injuryBlunt cardiac injury
Troponin levels should also be ordered. Important to note, negative findings on both ECG and troponin levels do not exclude BCI ... If both ECG and troponin levels are abnormal, an appropriate next step in evaluation would involve ordering an echocardiography ... As mentioned under Evaluation, an abnormal ECG and elevated troponin levels should elicit continued cardiac monitoring to look ...
https://en.wikipedia.org/wiki/Blunt_cardiac_injury
Actin, alpha skeletal muscleActin, alpha skeletal muscle
A novel troponin T-like protein". Hypertension. 11 (6 Pt 2): 620-6. doi:10.1161/01.hyp.11.6.620. PMID 2455687. Taylor A, Erba ... troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human ...
https://en.wikipedia.org/wiki/Actin,_alpha_skeletal_muscle
Fetal proteinFetal protein
Fetal Troponin T and Troponin I isoforms. Kal-Koshvandi AT (July 2020). "Recent advances in optical biosensors for the ...
https://en.wikipedia.org/wiki/Fetal_protein
C-RafC-Raf
Pfleiderer P, Sumandea MP, Rybin VO, Wang C, Steinberg SF (2009). "Raf-1: a novel cardiac troponin T kinase". J. Muscle Res. ... cardiac muscle troponin T (TnTc), etc. The retinoblastoma protein (pRb) and Cdc25 phosphatase were also suggested as possible ...
https://en.wikipedia.org/wiki/C-Raf
Smooth muscleSmooth muscle
... does not contain the protein troponin; instead calmodulin (which takes on the regulatory role in smooth muscle), ... Contraction is initiated by a calcium-regulated phosphorylation of myosin, rather than a calcium-activated troponin system. ... smooth muscle does not contain the calcium-binding protein troponin. ...
https://en.wikipedia.org/wiki/Smooth_muscle
CPK-MB testCPK-MB test
Troponin "CREATINE KINASE - MB CK-MB LQ" (PDF). Cabaniss, C. Daniel (1990), Walker, H. Kenneth; Hall, W. Dallas; Hurst, J. ... the test has been superseded by the troponin test. However, recently, there have been improvements to the test that involve ...
https://en.wikipedia.org/wiki/CPK-MB_test
Myocardial contractilityMyocardial contractility
Sensitizing troponin-C to the effects of calcium. Phosphorylating L-type calcium channels. This will increase their ... More calcium available for Troponin to use will increase the force developed. Decreasing contractility is done primarily by ...
https://en.wikipedia.org/wiki/Myocardial_contractility
Polycystin 2Polycystin 2
Li Q, Shen PY, Wu G, Chen XZ (January 2003). "Polycystin-2 interacts with troponin I, an angiogenesis inhibitor". Biochemistry ...
https://en.wikipedia.org/wiki/Polycystin_2
TNNI3TNNI3
It is a tissue-specific subtype of troponin I, which in turn is a part of the troponin complex. The TNNI3 gene encoding cardiac ... Vassylyev DG, Takeda S, Wakatsuki S, Maeda K, Maéda Y (Apr 1998). "Crystal structure of troponin C in complex with troponin I ... Noland TA, Raynor RL, Kuo JF (Dec 1989). "Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by ... Martin AF (Jan 1981). "Turnover of cardiac troponin subunits. Kinetic evidence for a precursor pool of troponin-I". The Journal ...
https://en.wikipedia.org/wiki/TNNI3
Protein kinase AProtein kinase A
Shah, Ajay M.; Solaro, R. John; Layland, Joanne (2005-04-01). "Regulation of cardiac contractile function by troponin I ... troponin I, myosin binding protein C, and potassium channels. This increases inotropy as well as lusitropy, increasing ...
https://en.wikipedia.org/wiki/Protein_kinase_A
Arterial occlusionArterial occlusion
Serum troponin elevation is a characteristic biomarker of MI. Depending on the severity of ischemia, MIs are categorized as ... Wu AH (2017-09-01). "Release of cardiac troponin from healthy and damaged myocardium". Frontiers in Laboratory Medicine. 1 (3 ... Lactate accumulation reduces contractility and eventually necroses cardiomyocytes, releasing their troponin storage into the ...
https://en.wikipedia.org/wiki/Arterial_occlusion
HeartHeart
Calcium ions also combine with the regulatory protein troponin C in the troponin complex to enable contraction of the cardiac ... Two tests of troponin are often taken-one at the time of initial presentation, and another within 3-6 hours, with either a high ... Troponin is a sensitive biomarker for a heart with insufficient blood supply. It is released 4-6 hours after injury, and ... These are mostly associated with muscle contraction, and bind with actin, myosin, tropomyosin, and troponin. They include MYH6 ...
https://en.wikipedia.org/wiki/Heart
TPM1TPM1
Tanokura M, Ohtsuki I (1984). "Interactions among chymotryptic troponin T subfragments, tropomyosin, troponin I and troponin C ... Pearlstone JR, Smillie LB (1983). "Effects of troponin-I plus-C on the binding of troponin-T and its fragments to alpha- ... In human cardiac muscle the ratio of α-Tm to β-Tm is roughly 5:1. Tm functions in association with the troponin complex to ... In addition to actin, Tm binds troponin T (TnT). TnT tethers the region of head-to-tail overlap of subsequent Tm molecules to ...
https://en.wikipedia.org/wiki/TPM1
Heart-type fatty acid binding proteinHeart-type fatty acid binding protein
H-FABP measured with troponin shows increased sensitivity of 20.6% over troponin at 3-6 hours following chest pain onset. This ... The effectiveness of using the combination of H-FABP with troponin to diagnose MI within 6 hours is well reported. In addition ... FABP3 is known to interact with TNNI3K in the context of interacting with cardiac troponin I. The protein also interacts with, ... Alongside D-dimer, NT-proBNP and peak troponin T, it was the only cardiac biomarker that proved to be a statistically ...
https://en.wikipedia.org/wiki/Heart-type_fatty_acid_binding_protein
Acute pericarditisAcute pericarditis
Troponin levels increase in 35-50% of people with pericarditis. Electrocardiogram (ECG) changes in acute pericarditis mainly ... Acute pericarditis is associated with a modest increase in serum creatine kinase MB (CK-MB). and cardiac troponin I (cTnI), ...
https://en.wikipedia.org/wiki/Acute_pericarditis
Calcium-binding protein 1Calcium-binding protein 1
Tsalkova TN, Privalov PL (1985). "Thermodynamic study of domain organization in troponin C and calmodulin". Journal of ...
https://en.wikipedia.org/wiki/Calcium-binding_protein_1
TropomyosinTropomyosin
Calcium ions then bind to troponin, which is associated with tropomyosin. Binding causes changes in the shape of troponin and ... The thin filament is made of actin, tropomyosin, and troponin. The contraction of skeletal muscle is triggered by nerve ... Structural and biochemical studies suggest that the position of tropomyosin and troponin on the thin filament regulates the ... Causative mutations have been detected in skeletal α-actinin, tropomyosin, nebulin, and troponin. Within humans, mutations in ...
https://en.wikipedia.org/wiki/Tropomyosin
Calponin 1Calponin 1
"Entrez Gene: calponin 1, basic, smooth muscle". Takahashi K, Abe M, Hiwada K, Kokubu T (December 1988). "A novel troponin T- ... Jin JP, Zhang Z, Bautista JA (2008). "Isoform diversity, regulation, and functional adaptation of troponin and calponin". ...
https://en.wikipedia.org/wiki/Calponin_1
Cardiac Troponin Release Following CABGCardiac Troponin Release Following CABG
This study aimed to elucidate possible mechanisms of cardiac troponin release in patients undergoing CABG. What might be the ... 1 and based on cardiac troponin T exclusively for assay comparability). (B) Cardiac troponin I vs. cardiac troponin T following ... 1 and based on cardiac troponin T exclusively for assay comparability). (B) Cardiac troponin I vs. cardiac troponin T following ... Differences Between Cardiac Troponin I and T for Diagnosis of Periprocedural Myocardial Infarction. Cardiac troponin I and T ...
https://www.medscape.com/viewarticle/987054
Troponin Test: MedlinePlus Medical TestTroponin Test: MedlinePlus Medical Test
High troponin levels may be a sign of a heart attack. Learn more. ... A troponin test measures the level of troponin in the blood. ... What is a troponin test?. A troponin test measures the level of troponin in your blood. Troponin is a type of protein found in ... Other names: cardiac troponin I (cTnI), cardiac troponin T (cTnT), cardiac troponin (cTN), cardiac-specific troponin I and ... Is there anything else I need to know about a troponin test?. New studies show that a new type of troponin blood test may be ...
https://medlineplus.gov/lab-tests/troponin-test/
Myocardial Infarction Workup: Approach Considerations, Cardiac Biomarkers/Enzymes, Troponin LevelsMyocardial Infarction Workup: Approach Considerations, Cardiac Biomarkers/Enzymes, Troponin Levels
Troponin Levels. Troponin is a contractile protein that normally is not found in serum. It is released only when myocardial ... Improved cardiac troponin assays offer even greater diagnostic accuracy than the standard assays do, according to a study by ... Troponin levels are now considered to be the criterion standard for defining and diagnosing myocardial infarction, according to ... Positive troponin levels are considered virtually diagnostic of myocardial infarction, according to a revised version of the ...
http://emedicine.medscape.com/article/155919-workup
New features of troponin testing in different clinical settingsNew features of troponin testing in different clinical settings
Cardiac troponin measurements also provide information concerning prognosis and the effect of early intervention in patients ... Cardiac troponin levels are routinely measured for diagnosing acute myocardial infarction. ... Cardiac troponin levels are routinely measured for diagnosing acute myocardial infarction. Cardiac troponin measurements also ... New features of troponin testing in different clinical settings J Intern Med. 2010 Sep;268(3):207-17. doi: 10.1111/j.1365- ...
https://pubmed.ncbi.nlm.nih.gov/20626552/?dopt=Abstract
Serum cardiac troponinSerum cardiac troponin
... I levels were elevated in dogs with acute ischaemic stroke, although they had no prognostic value in ... Cardiac troponins are routinely used as biomarkers for the diagnosis of acute myocardial infarction in humans, and increased ... Preliminary investigation of serum cardiac troponin I in dogs with acute ischaemic stroke by Rita Gonçalves and colleagues at ... This prospective study of 18 dogs with acute ischaemic stroke diagnosed by brain MRI detected increased cardiac troponin I ...
https://bsava.com/petsavers/our-impact/published-outputs/serum-cardiac-troponin/
Next-Generation Troponin Test Cleared by FDA | MedPage TodayNext-Generation Troponin Test Cleared by FDA | MedPage Today
Next-Generation Troponin Test Cleared by FDA. - Results with low detection threshold in under 10 minutes. by Crystal Phend, ... Moreover, the company is not allowed to call it a â high-sensitivityâ troponin T test, advised by the FDA to use the term â ... The FDA cleared the first in a new generation of cardiac troponin T (TnT) blood tests for rapid diagnosis of acute MI, Roches ... The companys fifth-generation blood test uses two monoclonal antibodies against cardiac troponin T to pick up the marker of ...
https://www.medpagetoday.com/cardiology/myocardialinfarction/62620
Lab Test: Troponin T | Akron Childrens HospitalLab Test: Troponin T | Akron Children's Hospital
While we are ranked among the best childrens hospitals in the country, its our compassionate approach to treatment that makes us truly exceptional. Through a combination of revolutionary treatments and extraordinary patient experiences, our care does more than heal. It brings the entire family together for emotional support and understanding across multiple locations to reach you in the community where you live. Learn more... ...
https://www.akronchildrens.org/lab_tests/Troponin-T.html
Personer med emneord «Troponin» - Det medisinske fakultetPersoner med emneord «Troponin» - Det medisinske fakultet
Personer med emneord «Troponin» Navn. Telefon. E-post. Emneord. Atar, Dan Adjunct Professor +47 98074757 [email protected] ... Myocardial Infarction, Prevention of Reperfusion Injury, Troponin, Cardiovascular Pharmacotherapy, India, Nordic Atar, Dan ...
https://www.med.uio.no/?vrtx=tags&tag=Troponin&resource-type=person
Tnnt2 MGI Mouse Gene Detail - MGI:104597 - troponin T2, cardiacTnnt2 MGI Mouse Gene Detail - MGI:104597 - troponin T2, cardiac
View mouse Tnnt2 Chr1:135764092-135779998 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
http://www.informatics.jax.org/marker/MGI:104597
The Hunt for a Kidney Troponin | AACC.orgThe Hunt for a Kidney Troponin | AACC.org
AACC.org // Clinical Laboratory News // All Articles // The Hunt for a Kidney Troponin ... Alas, the hunt for the elusive kidney troponin continues. If recent reports are any indication, then perhaps it has always been ... Clearly [TIMP-2]×[IGFBP7] is no kidney troponin, and future studies should examine if combining it with clinical examinations, ...
https://www.aacc.org/cln/articles/2020/november/the-hunt-for-a-kidney-troponin
Quidel Triage Troponin I Test | QuidelQuidel Triage Troponin I Test | Quidel
Quidel Triage Troponin I is een volgende generatie immunofluorescentieassay die in combinatie met de Quidel Triage MeterPro op ... Quidel Triage Troponin I is een volgende generatie immunofluorescentieassay die in combinatie met de Quidel Triage MeterPro op ...
https://www.quidel.com/immunoassays/triage-test-kits/triage-troponin-i-test/nl
Looking Beyond Elevated Troponin: Using ECG to Validate Acute Cardiac Injury | GE Healthcare (Singapore)Looking Beyond Elevated Troponin: Using ECG to Validate Acute Cardiac Injury | GE Healthcare (Singapore)
Troponin can support diagnostic decision-making for cardiac injury or events, but not as a gold standard. Other tools, ...
https://www.gehealthcare.com/en-sg/insights/article/looking-beyond-elevated-troponin-using-ecg-to-validate-acute-cardiac-injury
troponin Archive - European Stroke Organisationtroponin Archive - European Stroke Organisation
Elevated troponin in acute ischemic stroke - a matter of debate?. 23/11/2018. ... 24Elevated troponin in acute ischemic stroke - a matter of debate?. ...
https://eso-stroke.org/tag/troponin/
SCOPe 2.06: Family h.1.25.1: Troponin TSCOPe 2.06: Family h.1.25.1: Troponin T
More info for Family h.1.25.1: Troponin T. Timeline for Family h.1.25.1: Troponin T: *Family h.1.25.1: Troponin T first ... Family h.1.25.1: Troponin T appears in SCOPe 2.05. *Family h.1.25.1: Troponin T appears in SCOPe 2.07. *Family h.1.25.1: ... Troponin T [90252] (2 species). *. Species Chicken (Gallus gallus) [TaxId:9031] [144262] (2 PDB entries). Uniprot P12620 159- ... Lineage for Family h.1.25.1: Troponin T. *Root: SCOPe 2.06 *. Class h: Coiled coil proteins [57942] (7 folds). ...
http://scop.berkeley.edu/sunid=90251&ver=2.06
Prevencios AI-driven HART CADhs Blood Test Significantly More Accurate than Troponin for Heart Disease Diagnosis in Diabetic...Prevencio's AI-driven HART CADhs Blood Test Significantly More Accurate than Troponin for Heart Disease Diagnosis in Diabetic...
Prevencio announces data demonstrating its HART CADhs blood test is more accurate than troponin for heart disease diagnosis in ... Prevencios AI-driven HART CADhs Blood Test Significantly More Accurate than Troponin for Heart Disease Diagnosis in Diabetic ... Prevencio announces data demonstrating its HART CADhs blood test is more accurate than troponin for heart disease diagnosis in ... HART CADhs had 81% accuracy (positive predictive value) as compared to high sensitivity troponins accuracy of 64% (positive ...
https://www.businesswire.com/news/home/20211116005610/en/Prevencio%E2%80%99s-AI-driven-HART-CADhs-Blood-Test-Significantly-More-Accurate-than-Troponin-for-Heart-Disease-Diagnosis-in-Diabetic-Patients
ACEP // Use of High-Sensitivity Cardiac Troponin in the Emergency DepartmentACEP // Use of High-Sensitivity Cardiac Troponin in the Emergency Department
Use of High-Sensitivity Cardiac Troponin in the Emergency Department policy statement ... Use of High-Sensitivity Cardiac Troponin in the Emergency Department August 2022 ... endorses the following principles regarding the use of high sensitivity cardiac troponin (hs-cTn) in the evaluation and ...
https://www.acep.org/patient-care/policy-statements/use-of-high-sensitivity-cardiac-troponin-in-the-emergency-department/
Randox Launch New High Sensitivity Troponin T ControlRandox Launch New High Sensitivity Troponin T Control
Troponin I and Troponin T.. As the name suggests the control is liquid ready to use for added convenience and ease of us. Three ... The ultra low Troponin T levels found in the Randox control are significantly lower than those found in other manufacturers QC ... Cardiac Troponins are widely used in the detection of Myocardial Infarction (MI) with even small elevations in the levels of ... The Acusera high sensitivity troponin T control has a shelf life of up to 4 years meaning the same lot of control material can ...
https://www.technologynetworks.com/diagnostics/product-news/randox-launch-new-high-sensitivity-troponin-t-control-222330
Finding Acute Coronary Syndromes (ACS) With Serial Troponin Testing for Rapid Assessment of Cardiac Ischemic Symptoms - Full...Finding Acute Coronary Syndromes (ACS) With Serial Troponin Testing for Rapid Assessment of Cardiac Ischemic Symptoms - Full...
The new highly sensitive assays LOD is ~800 fg/mL (800 fg/mL = 0.8 pg/mL = 0.0008 ng/mL) for cardiac troponin I, as compared ... This study will evaluate the ability of a high sensitivity cardiac troponin I (hs-cTnI) assay to detect and to rule-out high- ... The need for a highly sensitive assay for cardiac troponin is predicated on the observation that the URL of the true reference ... The definition is based on cardiac troponin as the biomarker of choice with any value above the 99th percentile of an assays ...
https://clinicaltrials.gov/show/NCT00880802
Correlation Study to establish Cardiac Troponin I Levels Obtained Using Non-Invasive Wearable with that of Standard or Care...Correlation Study to establish Cardiac Troponin I Levels Obtained Using Non-Invasive Wearable with that of Standard or Care...
The standard of care treatment for a problem like this is to draw blood and check for a biomarker called troponin I. If... ... Background: The standard of care treatment for a problem like this is to draw blood and check for a biomarker called troponin I ... A company called RCE Technologies has developed a non-invasive way to measure troponin I using a device with an optical sensor ... Correlation Study to establish Cardiac Troponin I Levels Obtained Using Non-Invasive Wearable with that of Standard or Care ...
https://www.bcm.edu/healthcare/clinical-trials/h-51255
Rat Cardiac Troponin Ⅰ (cTn-Ⅰ) ELISA kit | CSB-E08594r | CusabioRat Cardiac Troponin Ⅰ (cTn-Ⅰ) ELISA kit | CSB-E08594r | Cusabio
Rat Cardiac Troponin Ⅰ (cTn-Ⅰ) ELISA kit from Cusabio. Cat#: CSB-E08594r. US, UK & Europe Distribution. Online Order or Request ... Rat Cardiac Troponin Ⅰ (cTn-Ⅰ) ELISA kit , CSB-E08594r Cusabio Elisa Rat Cardiac Troponin Ⅰ (cTn-Ⅰ) ELISA kit , CSB-E08594r. ( ... Mouse cardiac troponin Ⅰ (cTn-Ⅰ) ELISA kit , CSB-E08421m , CusabioMouse cardiac troponin Ⅰ (cTn-Ⅰ) ELISA kit is Available at ... Canine Cardiac Troponin Ⅰ (cTn-Ⅰ) ELISA kit , CSB-E08772c , CusabioCanine Cardiac Troponin Ⅰ (cTn-Ⅰ) ELISA kit is Available at ...
https://joplink.net/rat-cardiac-troponin-ctn-elisa-kit-csb-e08594r/
Landmark Troponin Assay to Give Results at the Point-of-Care | SelectScienceLandmark Troponin Assay to Give Results at the Point-of-Care | SelectScience
Troponin I point-of-care test, showcased by Trinity Biotech at Medica this year. Enabling fast, accurate triage and ... Find out more about the new Meritas® Troponin I point-of-care test, showcased by Trinity Biotech at Medica this year. Enabling ... Landmark Troponin Assay to Give Results at the Point-of-Care. 27 November 2013 ...
https://www.selectscience.net/SelectScience-TV/Videos/landmark-troponin-assay-to-give-results-at-the-point-of-care/?VideoID=1796
Cellular FLICE-Like Inhibitory Protein (C-FLIP) and Troponin-I: Promising Markers for the Determination of the Vitality in...Cellular FLICE-Like Inhibitory Protein (C-FLIP) and Troponin-I: Promising Markers for the Determination of the Vitality in...
Cellular FLICE-Like Inhibitory Protein (C-FLIP) and Troponin-I: Promising Markers for the Determination of the Vitality in ...
https://www.aafs.org/research/cellular-flice-inhibitory-protein-c-flip-and-troponin-i-promising-markers-determination
Video: Converting to High-Sensitivity Troponin I - Siemens Healthineers MagyarországVideo: Converting to High-Sensitivity Troponin I - Siemens Healthineers Magyarország
Watch Professor Collinson talk about how high-sensitivity troponin I has transformed his cardiology department ... Converting to High-Sensitivity Troponin I: Making it Successful with Education and Communication. Cardiac troponin is a marker ... These videos are part of a series of educational videos focusing on the clinical utility of high-sensitivity troponin I. Hear ... In this five-minute video, youll see how the introduction of the high-sensitivity troponin I test has transformed the ...
https://www.siemens-healthineers.com/hu/laboratory-diagnostics/assays-by-diseases-conditions/cardiac-assays/tnih-paul-collinson
Anemia, hypoalbuminemia, and elevated troponin levels as risk factors for respiratory failure in patients with severe...Anemia, hypoalbuminemia, and elevated troponin levels as risk factors for respiratory failure in patients with severe...
Anemia, hypoalbuminemia, and elevated troponin levels as risk factors for respiratory failure in patients with severe ... troponin levels were risk factors for the need of IMV in. severe AECOPD. Identification of such high-risk patients. could ... Pavliša G, Labor M, Puretić H, Hećimović A, Jakopović M, Samaržija M. Anemia, hypoalbuminemia, and elevated troponin levels as ... G. Pavliša, M. Labor, H. Puretić, A. Hećimović, M. Jakopović i M. Samaržija, "Anemia, hypoalbuminemia, and elevated troponin ...
https://hrcak.srce.hr/clanak/294825
Development of a paper microfluidic surface enhanced Raman scattering assay for cardiac troponin I | (2020) | Tu | ...Development of a paper microfluidic surface enhanced Raman scattering assay for cardiac troponin I | (2020) | Tu | ...
Cardiac Troponin I (cTnI) has been widely used as a biomarker for early diagnosis of MI. Point-of-care (POC) testing is favored ... Development of a paper microfluidic surface enhanced Raman scattering assay for cardiac troponin I Author(s): Dandan Tu; John ...
https://spie.org/Publications/Proceedings/Paper/10.1117/12.2544558
Mouse cTnT/TNNT2 (Troponin T Type 2, Cardiac) ELISA Kit | G-EC-04844 | Gentaur Elisa KitsMouse cTnT/TNNT2 (Troponin T Type 2, Cardiac) ELISA Kit | G-EC-04844 | Gentaur Elisa Kits
Troponin T Type 2, Cardiac) ELISA Kit from Gentaur Elisa Kits. Cat Number: G-EC-04844. USA, UK & Europe Distribution. ... Human cTnT/TNNT2 (Troponin T Type 2, Cardiac) ELISA Kit , G-EC-02575 ... Monkey cTnT/TNNT2 (Troponin T Type 2, Cardiac) ELISA Kit , G-EC-05070 ... Porcine cTnT/TNNT2 (Troponin T Type 2, Cardiac) ELISA Kit , G-EC-05090 ...
https://caslab.com/mouse-ctnt-tnnt2-troponin-t-type-2-cardiac-elisa-kit-g-ec-04844/
Study Demonstrates Cardiac Troponin Analysis Can Help Identify Heart Disease Risk, Guide Treatment | Clinical Lab ProductsStudy Demonstrates Cardiac Troponin Analysis Can Help Identify Heart Disease Risk, Guide Treatment | Clinical Lab Products
Study Demonstrates Cardiac Troponin Analysis Can Help Identify Heart Disease Risk, Guide Treatment. Aug 23, 2016 , Heart ... Serial cardiac troponin measured using a high-sensitivity assay in stable patients with ischemic heart disease. J Am Coll ... Analysis of cardiac troponin from more than 4,000 patients with stable ischemic heart disease using a single-molecule counting ... In stable patients with recent acute coronary syndrome, researchers used single-molecule counting (SMC) of cardiac troponin I ( ...
https://clpmag.com/resource-center/research/study-demonstrates-cardiac-troponin-analysis-can-help-identify-heart-disease-risk-guide-treatment/
Potential impact of a novel pathway for suspected myocardial infarction utilising a new high-sensitivity cardiac troponin I...Potential impact of a novel pathway for suspected myocardial infarction utilising a new high-sensitivity cardiac troponin I...
Potential impact of a novel pathway for suspected myocardial infarction utilising a new high-sensitivity cardiac troponin I ... Potential impact of a novel pathway for suspected myocardial infarction utilising a new high-sensitivity cardiac troponin I ... Potential impact of a novel pathway for suspected myocardial infarction utilising a new high-sensitivity cardiac troponin I ...
https://emj.bmj.com/content/39/11/847.share
High-sensitivity Cardiac Troponin for the Evaluation of Patients With Suspected ACS: A True or a False Friend? | Revista...High-sensitivity Cardiac Troponin for the Evaluation of Patients With Suspected ACS: A True or a False Friend? | Revista...
High-sensitivity troponin vs contemporary troponin. *Rule-out of acute coronary syndrome: high-sensitivity troponin as a true ... High-sensitivity troponin vs contemporary troponin. *Rule-out of acute coronary syndrome: high-sensitivity troponin as a true ... cTn, cardiac troponin; hs-cTn, high-sensitivity cardiac troponin. *Some contemporary methods for measuring cTn allow the use of ... cTn, cardiac troponin; hs-cTn, high-sensitivity cardiac troponin. *Some contemporary methods for measuring cTn allow the use of ...
https://www.revespcardiol.org/en-high-sensitivity-cardiac-troponin-for-evaluation-articulo-S1885585719300714
Anti-Cardiac Troponin I Antibody - QED Bioscience IncAnti-Cardiac Troponin I Antibody - QED Bioscience Inc
Biological Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers ... Anti-Cardiac Troponin I Antibody quantity. Add to cart. SKU: 24002 Categories: Antibody Products, Hormones and Serum Protein ... Specificity These antibodies react specifically with human cardiac troponin I. There is no cross-reactivity with human skeletal ... They may also be used to affinity purify cardiac troponin I. ... Target Name Troponin I, cardiac muscle. Target ID Cardiac ...
https://www.qedbio.com/product/cardiac-troponin-i-2/
AssayAssaysCTnISensitivityCTnTConcentrationsElevationsMonoclonal AntibodySerum cardiac troponinProteinForm a unique fingerprintAnti-troponinLaboratoryBiomarkerDiagnosis of acuteProteinsClinicalMarkerHuman cardiacLevelsELISAReactivityMyocardial injuryNormally found in the bHighComplexCreatineIschemicMarkersImprovesStratificationCoronaryBloodTestConcentration
Assay20
  • However, increased sensitivity comes with a cost of decreased specificity, and serial testing, as well as clinical context and judgment, is likely to become increasingly important in the interpretation of troponin assay results. (nih.gov)
  • Moreover, the company is not allowed to call it a â high-sensitivityâ troponin T test, advised by the FDA to use the term â next generationâ instead, although it is the same test referred to as a high-sensitivity TnT assay in published studies and outside the U.S., she said. (medpagetoday.com)
  • The new control allows clinical laboratories to more accurately monitor and assess the performance of their hsTnT (High Sensitivity Troponin T) assay. (technologynetworks.com)
  • In light of this both the European Society of Cardiology (ESC) and the American College of Cardiology (ACC) recommend the use of a highly sensitive troponin assay with excellent precision (less than 10% CV) at the 99th percentile of the reference range. (technologynetworks.com)
  • The recent launch of the Randox Acusera High Sensitivity Troponin T Control has changed things and now provides laboratories with the ability to more accurately monitor and assess the performance of their hsTnT assay. (technologynetworks.com)
  • For patients presenting with clinical suspicion of ACS, hs-cTnI provides improved prognostic information with regard to 180 day event rates of Major Adverse Cardiac Event outcomes, including cardiac deaths which are defined as all deaths except those that are clearly non-cardiac in nature (e.g. trauma), when compared to a currently available troponin assay. (clinicaltrials.gov)
  • For patients presenting with clinical suspicion of ACS, hs-cTnI provides improved sensitivity for detecting AMI within the first two (2) hours after presentation when compared to a currently available troponin assay. (clinicaltrials.gov)
  • For patients presenting with clinical suspicion of ACS, hs-cTnI provides improved negative predictive value for ruling out ACS (AMI or UA) within the first 2 hours after presentation when compared to a currently available troponin assay. (clinicaltrials.gov)
  • For alternative endpoints of cardiac mortality, and for alternative censor time points of 30 days, 90 days, and 1 year, hs-cTnI provides improved prognostic information when compared to the currently available troponin assay. (clinicaltrials.gov)
  • This study will evaluate the ability of a high sensitivity cardiac troponin I (hs-cTnI) assay to detect and to rule-out high-risk ischemic cardiac injury in emergency room patients experiencing signs and symptoms consistent with acute coronary syndromes (ACS). (clinicaltrials.gov)
  • These videos are part of a series of educational videos focusing on the clinical utility of high-sensitivity troponin I. Hear other leaders in the area of cardiovascular disease and laboratory diagnostics discuss implementing a high-sensitivity troponin I assay into their facility. (siemens-healthineers.com)
  • Serial cardiac troponin measured using a high-sensitivity assay in stable patients with ischemic heart disease. (clpmag.com)
  • RePub, Erasmus University Repository: A rapid troponin I assay is not optimal for determination of troponin status and prediction of subsequent cardiac events at suspicion of unstable coronary syndromes. (eur.nl)
  • METHODS AND RESULTS: A rapid troponin I assay was performed prior to inclusion in 4447 acute coronary syndrome patients in the GUSTO-IV trial. (eur.nl)
  • CONCLUSION: In a population with non-ST elevation acute coronary syndrome a positive rapid troponin I assay is a specific indicator of troponin elevation and a predictor of early outcome. (eur.nl)
  • hs-cTnI was measured in stored plasma using the ARCHITECT STAT High Sensitive Troponin-I assay (Abbott Diagnostics, Chicago, IL). (diabetesjournals.org)
  • hs-cTnT was measured in stored plasma using the Elecsys Troponin T assay (Roche Diagnostics, Indianapolis, IN). (diabetesjournals.org)
  • This prospective cohort study aimed to define a threshold using high-sensitivity cardiac troponin-I assay that identifies patients with suspected acute coronary syndrome who are at low risk of MI and would potentially be suitable for discharge. (2minutemedicine.com)
  • Hs-troponin I (Siemens), TNIH assay, was measured using the Siemens Centaur XP. (cdc.gov)
  • For hs-troponin T (Roche) and hs-troponin I (Ortho), low values were initially blinded for each assay. (cdc.gov)
Assays13
  • [ 35 ] Additional studies are needed to determine the relative analytic performance of different POCT assays for troponins, creatine phosphokinase-myocardial band (CPK-MB) and myoglobin alone or in combination in the current state of analytical technologies. (medscape.com)
  • The recent development of highly sensitive cardiac troponin assays permits detection of very low circulating levels. (nih.gov)
  • Use of sensitive troponin assays improves overall diagnostic accuracy in patients with suspected acute coronary syndromes, and these assays provide strong prognostic information in stable coronary artery disease and chronic heart failure. (nih.gov)
  • For patients presenting with clinical suspicion of Acute Coronary Syndromes (ACS), high sensitivity-cardiac Troponin I (hs-cTnI) provides improved diagnostic accuracy for ACS (including Acute Myocardial Infarction (AMI) and/or Unstable Angina (UA)) within the first two (2) hours after emergency department presentation when compared to currently available troponin assays. (clinicaltrials.gov)
  • Siemens Healthineers offers proven, true high-sensitivity troponin I assays that provide fast, actionable, and reliable results you can count on. (siemens-healthineers.com)
  • High-sensitivity cardiac troponin (hs-cTn) assays were introduced in Spain in 2010. (revespcardiol.org)
  • This prospective cohort study assessed the negative predictive value of high-sensitivity cardiac troponin-I assays for index MI, with the aim of identifying low risk patients that could be safely discharged. (2minutemedicine.com)
  • If further validated in clinical practice, high-sensitivity cardiac troponin-I assays could potentially decrease unnecessary or low risk cardiac admissions by up to two-thirds and achieve significant cost-savings for health care systems. (2minutemedicine.com)
  • Several guidelines and research activities recognize that improved analytical sensitivity of cardiac troponin assays over the last several years has allowed for detection of other etiologies. (clevelandheartlab.com)
  • There is no high-dose hook effect at Troponin T concentrations up to 100,000 ng/L. For assays using antibodies, the possibility exists for interference by heterophile antibodies in the patient's sample. (clevelandheartlab.com)
  • The panel recommended retrospective troponin data analyses, prospective longitudinal troponin collection using high-sensitivity cardiac troponin I assays, inclusion of troponin in future clinical trial outcomes and future development of clinical guidelines for monitoring and treating troponin elevations in DMD. (northwestern.edu)
  • The winner of the Clinical Video Interview of the Year was our very own 'High-sensitivity cardiac troponin assays and the power of point of care in the emergency department' which is an interview with Dr. Frank Peacock, professor of emergency medicine and vice chair of research, department of emergency medicine at Baylor College of Medicine. (siemens-healthineers.com)
  • In the winning video, Peacock discusses the importance of cardiac troponin as a biomarker for myocardial infarction, highlights the benefits of high-sensitivity versus contemporary troponin assays, and shares why point-of-care testing is a powerful tool in the emergency department. (siemens-healthineers.com)
CTnI6
  • Cardiac Troponin I (cTnI) has been widely used as a biomarker for early diagnosis of MI. (spie.org)
  • In stable patients with recent acute coronary syndrome, researchers used single-molecule counting (SMC) of cardiac troponin I (cTnI) to identify patients' risk for worsening of their cardiovascular disease. (clpmag.com)
  • High-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) are measures of subclinical cardiac damage associated with cardiovascular risk in the general population ( 1 , 2 ). (diabetesjournals.org)
  • We assessed whether hs-cTnI or hs-cTnT could improve cardiovascular and mortality risk stratification in adults with diabetes and whether elevated concentrations of either troponin (≥90th percentile) were associated with mortality risk similar to those having a history of clinical CVD. (diabetesjournals.org)
  • Phosphorylation levels of cardiac troponin I (cTnI) were determined by Western blot. (cdc.gov)
  • a proposed new serum marker is cardiac troponin I (cTnI). (ucl.ac.uk)
Sensitivity22
  • Adoption of high-sensitivity troponin testing is likely to require coupling with management protocols that guide interpretation and care if the benefits of greater diagnostic discrimination are to be harnessed," the study researchers had concluded. (medpagetoday.com)
  • KIRKLAND, Wash.--( BUSINESS WIRE )-- Prevencio, Inc. today announces the presentation of multinational patient data demonstrating its HART CADhs blood test is significantly more accurate than high sensitivity troponin in determining whether a diabetic patient has obstructive heart disease. (businesswire.com)
  • We were pleased to find that this novel diagnostic score blood test can predict obstructive coronary artery disease in diabetics with high accuracy across three multinational patient groups and was significantly more accurate than high sensitivity troponin," said Christopher deFilippi, MD, a practicing cardiologist and Vice Chairman of Academic Affairs at Inova Heart and Vascular Institute. (businesswire.com)
  • Randox Laboratories has announced the launch of a new high sensitivity troponin T control. (technologynetworks.com)
  • Before now, suitable control materials for high sensitivity Troponin T with target values sufficiently close to the 99th percentile of the reference range (14ng/L) were unavailable. (technologynetworks.com)
  • The Acusera high sensitivity troponin T control has a shelf life of up to 4 years meaning the same lot of control material can be used for longer thus reducing the problems associated with lot crossovers. (technologynetworks.com)
  • In this five-minute video, you'll see how the introduction of the high-sensitivity troponin I test has transformed the cardiology department at St George's, University of London (UK). (siemens-healthineers.com)
  • High-sensitivity Cardiac Troponin for the Evaluation of Patients With Suspected ACS: A True or a False Friend? (revespcardiol.org)
  • Biological Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (qedbio.com)
  • Methods: In this single-centre prospective observational cohort study, serial high-sensitivity cardiac troponin T (hscTnT) plasma concentrations were obtained from young, healthy adults undergoing elective orthopaedic surgery at three time points: before operation, 2-6 h, and 18-30 h after surgery. (elsevier.com)
  • Cardiotoxicity as indicated by LVEF and troponin T sensitivity following two anthracycline-based regimens in lymphoma: Results from a randomized prospective. (oncotarget.com)
  • Left ventricular ejection fraction (LVEF) and high-sensitivity serum cardiac troponin T (HsTnT) were assessed at baseline and after 4 cycles of treatment. (oncotarget.com)
  • Researchers have found that elevated high-sensitivity cardiac troponin T (hs-cTnT) levels may be an independent predictor of cerebral microbleeds (CMBs) in patients with acute ischemic stroke who have atrial fibrillation (afib), rheumatic heart disease, or both. (neurologyadvisor.com)
  • The impact of lifestyle-related factors on temporal decreases in high-sensitivity cardiac troponin T (hs-cTnT), possibly reflecting reversal of subclinical myocardial damage, has not been evaluated in a community-based setting. (elsevier.com)
  • High sensitivity Troponin T (hs-TnT) is an independent prognostic marker that aids in the diagnosis of myocardial infarction (MI) in an acute setting and there is literature supporting its use to identify relative risk of cardiovascular disease (CVD). (clevelandheartlab.com)
  • Sera from stored surplus specimens in the NHANES 1999-2004 cycles were tested for high-sensitivity (hs)-troponin T (Roche), hs-troponin I (Abbott), hs-troponin I (Siemens) and hs-troponin I (Ortho). (cdc.gov)
  • The results for high-sensitivity cardiac troponin in this data release are reported in nanograms per liter (ng/L). (cdc.gov)
  • This study was undertaken to investigate whether high- sensitivity cardiac troponin T (hs-cTnT) is associated with major adverse cardiovascular events ( MACE ) in patients with minor stroke or transient ischemic attack (TIA), and whether this association differs after risk stratification based on the Age, Blood Pressure , Clinical Features, Duration of Symptoms, Diabetes (ABCD2 ) score. (bvsalud.org)
  • Having high-sensitivity troponin testing at the point of care-producing accurate results in just 8 minutes-could transform care delivery for millions of people each year, improving ED throughput, reducing stress and strain on acute care clinicians, and aiding in optimizing the use of time and resources of busy laboratories. (siemens-healthineers.com)
  • Simple to use and easily integrated into existing systems, the Atellica® VTLi Patient-side Immunoassay Analyzer, powered by Magnotech® Technology, delivers accurate, clinically actionable high-sensitivity troponin I results directly in the hands of those who need it most. (siemens-healthineers.com)
  • Performance of the ESC 0/2h-algorithm using high-sensitivity cardiac troponin I in the early diagnosis of myocardial infarction. (unibas.ch)
  • It aims to improve outcomes by providing advice on tests (ECG, high-sensitivity troponin tests, multislice CT angiography, functional testing) that support he. (bvsalud.org)
CTnT2
  • DS-01-0458 is human cardiac Troponin T, also known as cTnT. (raybiotech.com)
  • Cardiac troponin T (cTnT) is a regulatory contractile protein not normally found in blood. (who.int)
Concentrations9
  • Indeed, CABG inherently induces the release of cardiac biomarkers, as reflected by significant cardiac troponin (cTn) concentrations in patients with uncomplicated postoperative courses. (medscape.com)
  • Cardiac troponins are routinely used as biomarkers for the diagnosis of acute myocardial infarction in humans, and increased troponin concentrations have been detected in both congenital and acquired heart diseases of dogs. (bsava.com)
  • A significant association was found between cardiac troponin I and creatinine concentrations, but no difference in cardiac troponin I concentrations was seen between dogs that experienced good and poor outcomes. (bsava.com)
  • Cardiac troponin concentrations are important sensitive and specific markers for myocardial injury in clinical medicine. (elsevier.com)
  • 2. At 1 year, patients with serum troponin concentrations of less than 5ng/L were at a lower risk of MI and cardiac death than those with troponin concentrations of 5ng/L or more. (2minutemedicine.com)
  • Troponin concentrations in patients without MI at presentation were less than 5ng/L in 2,311 (61%) of 3,799 patients with a negative predictive value of 99.6% (95% CI 99.3-99.8) for the primary outcome. (2minutemedicine.com)
  • Troponin concentrations were less than 5ng/L in 594 (56%) of 1,061 patients in two independent validation cohorts and had a negative predictive value of 99.4% (95% CI 98.8-99.1). (2minutemedicine.com)
  • Elevated concentrations of cardiac troponin can also occur in other clinical conditions such as heart failure, heart contusion, and drug‑induced cardiotoxicity. (clevelandheartlab.com)
  • Very low concentrations of hs-troponin are associated with greater variability and are not routinely reported for clinical use. (cdc.gov)
Elevations8
  • Cardiac Troponins are widely used in the detection of Myocardial Infarction (MI) with even small elevations in the levels of cardiac troponin indicating damage to the heart and possible MI. (technologynetworks.com)
  • Elevations of troponin in patients with epileptic seizures? (elsevier.com)
  • Troponin (TnT) elevations have been noted in some series in the setting of acute neurologic disease. (elsevier.com)
  • Elevations of troponin should not be considered to be due to isolated seizures. (elsevier.com)
  • Dive into the research topics of 'Elevations of troponin in patients with epileptic seizures? (elsevier.com)
  • Chronic cardiac troponin elevations can be detected in clinically stable patients such as patients with ischemic or non‑ischemic heart failure, patients with different forms of cardiomyopathy, renal failure, sepsis, and diabetes. (clevelandheartlab.com)
  • Clinical evaluations over time have demonstrated asymptomatic cardiac troponin elevations and acute elevations are associated with symptoms and cardiac dysfunction in DMD. (northwestern.edu)
  • N-terminal B-type natriuretic peptide or troponin elevations, or the Background use of inotropes during admission, are much more powerful and Risk stratification and prediction is an integral part of clinical accurate predictors than admission to hospital alone. (who.int)
Monoclonal Antibody2
  • Western blots employing a mammalian anti-troponin T monoclonal antibody were used to identify TnT isoforms. (biologists.com)
  • Immunological identity has been confirmed by reaction with a monoclonal antibody specific for Troponin T cardiac isoform. (raybiotech.com)
Serum cardiac troponin3
  • Serum cardiac troponin I levels were elevated in dogs with acute ischaemic stroke, although they had no prognostic value in this preliminary study. (bsava.com)
  • IMSEAR at SEARO: Serum cardiac troponin T in unstable angina pectoris patients. (who.int)
  • Leowattana W, Mahanonda N, Bhuripanyo K, Pokum S, Kiartivich S. Serum cardiac troponin T in unstable angina pectoris patients. (who.int)
Protein3
  • Troponin is a type of protein found in the muscles of your heart. (medlineplus.gov)
  • Where intracellular ca binds to the thinfilamentassociated protein troponin chacko and longhurst. (dboagency.com)
  • Doctors currently test for the troponin protein, but the CRP test has now been recommended as it provides a clearer picture of heart damage and risk of death in heart-attack patients. (bivdanewsletter.com)
Form a unique fingerprint1
  • Dive into the research topics of 'Spectrofluorometric analysis of length-dependent conformational changes in cardiac troponin C'. Together they form a unique fingerprint. (ntnu.edu.tw)
Anti-troponin1
  • Sacituzumab govitecan (Immunomedics) is an antibody-drug conjugate consisting of an anti-troponin (Trop)-2 antibody conjugated to SN-38. (informa.com)
Laboratory1
  • A quantitative troponin T analysis was later performed on blood samples obtained at randomization by a central laboratory. (eur.nl)
Biomarker1
  • The standard of care treatment for a problem like this is to draw blood and check for a biomarker called troponin I. If these blood levels are elevated, it indicates that you have had damage to your heart. (bcm.edu)
Diagnosis of acute1
  • The FDA cleared the first in a new generation of cardiac troponin T (TnT) blood tests for rapid diagnosis of acute MI, Roche's Elecsys TnT Gen 5 STAT test, the firm said Thursday . (medpagetoday.com)
Proteins1
  • Blood tests, including troponin blood tests, look for the presence of specific proteins, called troponin T or troponin I, which are released into the body when the heart is damaged or during a heart attack. (sclhealth.org)
Clinical4
  • Three levels are available spanning the complete clinical range with cut off levels for both Troponin I and T in line with international recommendations. (technologynetworks.com)
  • Analysis of cardiac troponin from more than 4,000 patients with stable ischemic heart disease using a single-molecule counting technology developed by Singulex Inc, Alameda, Calif, has demonstrated utility and clinical information for the analysis of cardiac health. (clpmag.com)
  • This case illustrates the importance of having data concerning the response of troponin in various emergency and clinical situations. (elsevier.com)
  • As clinical trials begin to assess novel cardiac therapeutics in DMD, troponin levels in DMD are important for safety monitoring and outcome measures. (northwestern.edu)
Marker4
  • The company's fifth-generation blood test uses two monoclonal antibodies against cardiac troponin T to pick up the marker of myocardial damage with a turn-around time of 9 minutes. (medpagetoday.com)
  • Cardiac troponin is a marker of cardiac injury, enabling clinicians to aid in the diagnosis of myocardial infarction. (siemens-healthineers.com)
  • Our findings support the potential broadening of a paradigm from viewing cardiac troponin solely as a transiently elevated diagnostic marker in the setting of acute injury to also using the information as a marker of ongoing heightened cardiovascular risk," says Bonaca, principal investigator of the study. (clpmag.com)
  • BACKGROUND: Troponin is a specific marker of myocardial damage. (eur.nl)
Human cardiac2
  • Immunogen Purified human cardiac troponin I. (qedbio.com)
  • Application Instructions These antibodies may be used in immunoassays and Western blots to detect and quantitate human cardiac troponin I. They may also be used to affinity purify cardiac troponin I. (qedbio.com)
Levels9
  • High levels of troponin in the blood may mean you are having or recently had a heart attack . (medlineplus.gov)
  • This is done to see if there are any changes in troponin levels over time. (medlineplus.gov)
  • If your results show normal troponin levels for 12 hours after chest pain has started, it's unlikely that your symptoms were caused by a heart attack. (medlineplus.gov)
  • If high levels of troponin are found in one or more tests over time, it probably means you had a heart attack. (medlineplus.gov)
  • Cardiac troponin levels are routinely measured for diagnosing acute myocardial infarction. (nih.gov)
  • The ultra low Troponin T levels found in the Randox control are significantly lower than those found in other manufacturers QC material. (technologynetworks.com)
  • Clinicians require a better understanding of the relationship of symptoms, troponin levels and progression of cardiac disease in DMD. (northwestern.edu)
  • 2017. Association Between Troponin Levels and Embolic Stroke of Undetermined Source. . (cornell.edu)
  • Troponin levels and an ECG are normal. (medscape.com)
ELISA1
  • Rat Cardiac Troponin Ⅰ (cTn-Ⅰ) ELISA kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
Reactivity1
  • Recently, it has been shown that length-dependent changes in SH reactivity of cardiac troponin C (cTnC) occurred in association with cross-bridge attachment and Ca 2+ . (ntnu.edu.tw)
Myocardial injury2
  • Background: It is unclear if isolated postoperative cardiac-troponin elevation, often referred to as myocardial injury, represents a pathological event, as control studies in otherwise healthy adults are lacking. (elsevier.com)
  • These results may have important ramifications for the concept of postoperative myocardial injury, as they suggest that, in some patients, postoperative cardiac-troponin increases may be the result of a normal physiological process in the surgical setting. (elsevier.com)
Normally found in the b1
High2
  • 0.1 microg/l) the 30 day event rate was high regardless of the rapid troponin I result. (eur.nl)
  • In patients without heart attack at presentation, a troponin concentration less than 5ng/L was found to have a high negative predictive value of greater than 99% for index MI in both derivation and validation cohorts. (2minutemedicine.com)
Complex2
  • TnT is a component of the troponin complex that modulates muscle activation once Ca 2+ is bound. (biologists.com)
  • Expression of the troponin complex genes: transcriptional coactivation during myoblast differentiation and independent control in heart and skeletal muscles. (umassmed.edu)
Creatine1
  • To identify patients with periprocedural MI (PMI), several conflicting definitions of PMI have been proposed, relying either on cardiac troponin (cTn) or the MB isoenzyme of creatine kinase, with or without supporting evidence of ischaemia. (medscape.com)
Ischemic3
  • Elevated troponin in acute ischemic stroke - a matter of debate? (eso-stroke.org)
  • https://eso-stroke.org/wp-content/uploads/ESO-Horiz-mit-Schutzraum.png 0 0 ESO-admin https://eso-stroke.org/wp-content/uploads/ESO-Horiz-mit-Schutzraum.png ESO-admin 2018-11-23 09:27:24 2018-11-23 09:27:24 Elevated troponin in acute ischemic stroke - a matter of debate? (eso-stroke.org)
  • Cardiac Troponin and Recurrent Major Vascular Events after Minor Stroke or Transient Ischemic Attack. (bvsalud.org)
Markers1
  • Troponin T or troponin I as cardiac markers in ischaemic heart disease. (medlineplus.gov)
Improves1
  • Adding troponin to echocardiography improves preoperative abscess detection in infective endocarditis. (escardio.org)
Stratification1
  • or =0.1 microg/l provided a better risk stratification than the rapid troponin I result. (eur.nl)
Coronary1
  • Cardiac troponin measurements also provide information concerning prognosis and the effect of early intervention in patients with acute coronary syndromes. (nih.gov)
Blood5
  • A troponin test measures the level of troponin in your blood. (medlineplus.gov)
  • As heart damage increases, greater amounts of troponin are released in the blood. (medlineplus.gov)
  • If even a small level of troponin is found in your blood, it may mean there is some damage to your heart. (medlineplus.gov)
  • New studies show that a new type of troponin blood test may be able to identify people who are at greater risk for heart attacks before they even have symptoms. (medlineplus.gov)
  • Your doctor or the ER doctor will run an EKG and blood tests called Troponin to rule out a heart attack. (adventhealth.com)
Test7
Concentration1
  • 1. In this prospective cohort study, a low serum troponin concentration under 5ng/L had a negative predictive value of 99.6% for the primary outcome of index myocardial infarction (MI). (2minutemedicine.com)
Looking Beyond Elevated Troponin: Using ECG to Validate Acute Cardiac Injury | GE Healthcare (Singapore)
Looking Beyond Elevated Troponin: Using ECG to Validate Acute Cardiac Injury | GE Healthcare (Singapore) (gehealthcare.com)
Pulmonary Embolism (PE) Workup: Approach Considerations, Clinical Scoring Systems, D-Dimer Follow-Up on Low-to-Moderate Pretest...
Pulmonary Embolism (PE) Workup: Approach Considerations, Clinical Scoring Systems, D-Dimer Follow-Up on Low-to-Moderate Pretest... (medscape.com)
Pulmonary Embolism (PE) Workup: Approach Considerations, Clinical Scoring Systems, D-Dimer Follow-Up on Low-to-Moderate Pretest...
Pulmonary Embolism (PE) Workup: Approach Considerations, Clinical Scoring Systems, D-Dimer Follow-Up on Low-to-Moderate Pretest... (medscape.com)
Cardiac Markers: Definition and Efficacy, Markers of Myocardial Necrosis and Ischemia, Acute Coronary Syndrome Testing Strategy
Cardiac Markers: Definition and Efficacy, Markers of Myocardial Necrosis and Ischemia, Acute Coronary Syndrome Testing Strategy (medscape.com)
(emedicine.medscape.com)
Troponin, Echo a Prognostic Power Combo in COVID-19
Troponin, Echo a Prognostic Power Combo in COVID-19 (medscape.com)
Uptake of High-Sensitivity Troponin Assays Lags in US Hospitals
Uptake of High-Sensitivity Troponin Assays Lags in US Hospitals (medscape.com)
Cardiac Issues Twice as Likely With COVID Plus High Troponin
Cardiac Issues Twice as Likely With COVID Plus High Troponin (medscape.com)
HiSTORIC Validates High-Sensitivity Troponin Test to Rule Out MI
HiSTORIC Validates High-Sensitivity Troponin Test to Rule Out MI (medscape.com)
COVID-19 Vaccine Safety in Children Aged 5-11 Years - United States, November 3-December 19, 2021 | MMWR
COVID-19 Vaccine Safety in Children Aged 5-11 Years - United States, November 3-December 19, 2021 | MMWR (cdc.gov)
COVID-19 Vaccine Safety in Adolescents Aged 12-17 Years - United States, December 14, 2020-July 16, 2021 | MMWR
COVID-19 Vaccine Safety in Adolescents Aged 12-17 Years - United States, December 14, 2020-July 16, 2021 | MMWR (cdc.gov)
Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection - United Kingdom and United...
Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection - United Kingdom and United... (cdc.gov)
COVID-19-Associated Multisystem Inflammatory Syndrome in Children - United States, March-July 2020 | MMWR
COVID-19-Associated Multisystem Inflammatory Syndrome in Children - United States, March-July 2020 | MMWR (cdc.gov)
Fire Fighter Fatality Investigation Report F2006-17 | NIOSH | CDC
Fire Fighter Fatality Investigation Report F2006-17 | NIOSH | CDC (cdc.gov)
Prueba de troponina: Prueba de laboratorio de MedlinePlus
Prueba de troponina: Prueba de laboratorio de MedlinePlus (medlineplus.gov)
Cocaine Toxicity Workup: Laboratory Studies, Imaging Studies, Other Tests
Cocaine Toxicity Workup: Laboratory Studies, Imaging Studies, Other Tests (medscape.com)
Unstable Angina: Practice Essentials, Background, Pathophysiology
Unstable Angina: Practice Essentials, Background, Pathophysiology (medscape.com)
Unstable Angina Workup: Approach Considerations, Basic Blood Studies, Cardiac Biomarkers
Unstable Angina Workup: Approach Considerations, Basic Blood Studies, Cardiac Biomarkers (medscape.com)
Acute Coronary Syndrome: Practice Essentials, Background, Etiology
Acute Coronary Syndrome: Practice Essentials, Background, Etiology (medscape.com)
Unstable Angina Clinical Presentation: History, Physical Examination, Braunwald Classification
Unstable Angina Clinical Presentation: History, Physical Examination, Braunwald Classification (medscape.com)
Unstable Angina Treatment & Management: Approach Considerations, Initial Medical Management, Further Medical Management
Unstable Angina Treatment & Management: Approach Considerations, Initial Medical Management, Further Medical Management (medscape.com)
Troponin test: MedlinePlus Medical Encyclopedia
Troponin test: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Acute Coronary Syndrome Treatment & Management: Approach Considerations, Pharmacologic Anti-ischemic Therapy, Pharmacologic...
Acute Coronary Syndrome Treatment & Management: Approach Considerations, Pharmacologic Anti-ischemic Therapy, Pharmacologic... (medscape.com)
Myocardial Injury Secondary to ICD Shocks
Myocardial Injury Secondary to ICD Shocks (medscape.com)
A 'Mess' of a Diagnosis: Is it Type 2 MI or a Nonischemic Imposter?
A 'Mess' of a Diagnosis: Is it Type 2 MI or a Nonischemic Imposter? (medscape.com)