AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
TropomyosinTroponinActinsTropomodulinActin CytoskeletonMyosinsCalmodulin-Binding ProteinsGizzardMyosin SubfragmentsRabbitsMusclesActomyosinChickensMicrofilament ProteinsMyofibrilsMuscle ProteinsCa(2+) Mg(2+)-ATPaseTroponin TActininMuscle, SmoothProtein BindingTroponin CCytoskeletonAdenosine TriphosphatasesTroponin IMuscle, StriatedGelsolinElectrophoresis, Polyacrylamide GelViscosityCalciumAmino Acid SequenceMuscle, SkeletalProtein IsoformsMicroscopy, ElectronMyopathies, NemalinePhalloidineMolecular Weight
Tropomyosin
A protein found in the thin filaments of muscle fibers. It inhibits contraction of the muscle unless its position is modified by TROPONIN.
Troponin
One of the minor protein components of skeletal muscle. Its function is to serve as the calcium-binding component in the troponin-tropomyosin B-actin-myosin complex by conferring calcium sensitivity to the cross-linked actin and myosin filaments.
Actins
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Tropomodulin
An actin capping protein that binds to the pointed-end of ACTIN. It functions in the presence of TROPOMYOSIN to inhibit microfilament elongation.
Actin Cytoskeleton
Fibers composed of MICROFILAMENT PROTEINS, which are predominately ACTIN. They are the smallest of the cytoskeletal filaments.
Myosins
A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.
Calmodulin-Binding Proteins
Proteins which bind calmodulin. They are found in many tissues and have a variety of functions including F-actin cross-linking properties, inhibition of cyclic nucleotide phosphodiesterase and calcium and magnesium ATPases.
Gizzard
Myosin Subfragments
Parts of the myosin molecule resulting from cleavage by proteolytic enzymes (PAPAIN; TRYPSIN; or CHYMOTRYPSIN) at well-localized regions. Study of these isolated fragments helps to delineate the functional roles of different parts of myosin. Two of the most common subfragments are myosin S-1 and myosin S-2. S-1 contains the heads of the heavy chains plus the light chains and S-2 contains part of the double-stranded, alpha-helical, heavy chain tail (myosin rod).
Rabbits
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Muscles
Contractile tissue that produces movement in animals.
Actomyosin
A protein complex of actin and MYOSINS occurring in muscle. It is the essential contractile substance of muscle.
Chickens
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
Microfilament Proteins
Monomeric subunits of primarily globular ACTIN and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.
Myofibrils
The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES .
Muscle Proteins
The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.
Ca(2+) Mg(2+)-ATPase
Troponin T
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
Actinin
A protein factor that regulates the length of R-actin. It is chemically similar, but immunochemically distinguishable from actin.
Muscle, Smooth
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Troponin C
One of the three polypeptide chains that make up the TROPONIN complex of skeletal muscle. It is a calcium-binding protein.
Cytoskeleton
The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.
Adenosine Triphosphatases
A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.
Troponin I
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
Muscle, Striated
One of two types of muscle in the body, characterized by the array of bands observed under microscope. Striated muscles can be divided into two subtypes: the CARDIAC MUSCLE and the SKELETAL MUSCLE.
Gelsolin
A 90-kDa protein produced by macrophages that severs ACTIN filaments and forms a cap on the newly exposed filament end. Gelsolin is activated by CALCIUM ions and participates in the assembly and disassembly of actin, thereby increasing the motility of some CELLS.
Electrophoresis, Polyacrylamide Gel
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Viscosity
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Muscle, Skeletal
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Protein Isoforms
Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.
Microscopy, Electron
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Myopathies, Nemaline
A group of inherited congenital myopathic conditions characterized clinically by weakness, hypotonia, and prominent hypoplasia of proximal muscles including the face. Muscle biopsy reveals large numbers of rod-shaped structures beneath the muscle fiber plasma membrane. This disorder is genetically heterogeneous and may occasionally present in adults. (Adams et al., Principles of Neurology, 6th ed, p1453)
Phalloidine
Very toxic polypeptide isolated mainly from AMANITA phalloides (Agaricaceae) or death cup; causes fatal liver, kidney and CNS damage in mushroom poisoning; used in the study of liver damage.
Molecular Weight
The sum of the weight of all the atoms in a molecule.

Donor site competition is involved in the regulation of alternative splicing of the rat beta-tropomyosin pre-mRNA. (1/1370)

The rat beta-tropomyosin (beta-TM) gene encodes both skeletal muscle beta-TM mRNA and nonmuscle TM-1 mRNA via alternative RNA splicing. This gene contains eleven exons: exons 1-5, 8, and 9 are common to both mRNAs; exons 6 and 11 are used in fibroblasts as well as in smooth muscle, whereas exons 7 and 10 are used in skeletal muscle. Previously we demonstrated that utilization of the 3' splice site of exon 7 is blocked in nonmuscle cells. In this study, we use both in vitro and in vivo methods to investigate the regulation of the 5' splice site of exon 7 in nonmuscle cells. The 5' splice site of exon 7 is used efficiently in the absence of flanking sequences, but its utilization is suppressed almost completely when the upstream exon 6 and intron 6 are present. The suppression of the 5' splice site of exon 7 does not result from the sequences at the 3' end of intron 6 that block the use of the 3' splice site of exon 7. However, mutating two conserved nucleotides GU at the 5' splice site of exon 6 results in the efficient use of the 5' splice site of exon 7. In addition, a mutation that changes the 5' splice site of exon 7 to the consensus U1 snRNA binding site strongly stimulates the splicing of exon 7 to the downstream common exon 8. Collectively, these studies demonstrate that 5' splice site competition is responsible, in part, for the suppression of exon 7 usage in nonmuscle cells.  (+info)

Properties of non-polymerizable tropomyosin obtained by carboxypeptidase A digestion. (2/1370)

Tropomyosin digested with carboxypeptidase A [EC 3.4.12.2] (CTM) shows a lower viscosity than the undigested protein in solution. From the relation between the viscosity decrease and the amount of amino acids liberated from the carboxyl terminus during this digestion, it is inferred that loss of the tri-peptide-Thr-Ser-Ile from the C-terminus is responsible for the decrease in viscosity. The secondary structure of -TM was not affected by the digestion according to circular dichroic measurements. The viscosity of CTM did not increase in methanol-water mixtures, whereas that of tropomyosin increased markedly. These results indicate that polymerizability was lost upon the removal of a small peptide from the C-terminus without change in the secondary structure. A decrease in the viscosity of tropomyosin solutions was observed on the addition of CTM, indicating that CTM interacts with intact tropomyosin. The dependence of the viscosity decrease on the amount of CTM showed that CTM binds tropomyosin in a one-to-one ratio as a result of end-to-end interaction. Since paracrystals having a 400 A repeated band structure could be grown in the presence of Mg ions at neutral pH, side-by-side interactions in CTM molecules remain intact, even though polymerizability is lost. The disc gel electrophoretic pattern showed that troponin could bind to CTM, but no increase in viscosity due to the complex was observed in solution. That is, the C-terminal part of tropomyosin is not required for the formation of the complex. The amount of CTM bound to F-actin was less than half of that bound to undigested tropomyosin, and could be reduced to one-tenth by a washing procedure. In the presence of troponin, however, the amount recovered to the level of tropomyosin normally bound to F-actin. Therefore, it is concluded that troponin is bound in the middle of the tropomyosin molecule and strengthens the binding of tropomyosin to F-actin.  (+info)

Roles for the troponin tail domain in thin filament assembly and regulation. A deletional study of cardiac troponin T. (3/1370)

Striated muscle contraction is regulated by Ca2+ binding to troponin, which has a globular domain and an elongated tail attributable to the NH2-terminal portion of the bovine cardiac troponin T (TnT) subunit. Truncation of the bovine cardiac troponin tail was investigated using recombinant TnT fragments and subunits TnI and TnC. Progressive truncation of the troponin tail caused progressively weaker binding of troponin-tropomyosin to actin and of troponin to actin-tropomyosin. A sharp drop-off in affinity occurred with NH2-terminal deletion of 119 rather than 94 residues. Deletion of 94 residues had no effect on Ca2+-activation of the myosin subfragment 1-thin filament MgATPase rate and did not eliminate cooperative effects of Ca2+ binding. Troponin tail peptide TnT1-153 strongly promoted tropomyosin binding to actin in the absence of TnI or TnC. The results show that the anchoring function of the troponin tail involves interactions with actin as well as with tropomyosin and has comparable importance in the presence or absence of Ca2+. Residues 95-153 are particularly important for anchoring, and residues 95-119 are crucial for function or local folding. Because striated muscle regulation involves switching among the conformational states of the thin filament, regulatory significance for the troponin tail may arise from its prominent contribution to the protein-protein interactions within these conformations.  (+info)

Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene. (4/1370)

In the rat beta-tropomyosin (beta-TM) gene, exons 6 and 7 are spliced alternatively in a mutually exclusive manner. Exon 6 is included in mRNA encoding nonmuscle TM-1, whereas exon 7 is used in mRNA encoding skeletal muscle beta-TM. Previously, we demonstrated that a six nucleotide mutation at the 5' end of exon 7, designated as ex-1, activated exon 7 splicing in nonmuscle cells. In this study, we show that the activating effect of this mutation is not the result of creating an exonic splicing enhancer (ESE) or disrupting a putative secondary structure. The sequence in exon 7 acts as a bona fide exonic splicing silencer (ESS), which is bound specifically by a trans-acting factor. Isolation and peptide sequencing reveal that this factor is hnRNP H, a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. Binding of hnRNP H correlates with the ESS activity. Furthermore, addition of antibodies that specifically recognizes hnRNP H to the splicing reactions or partial depletion of hnRNP H from nuclear extract activates exon 7 splicing in vitro and this effect can be reversed by addition of purified recombinant hnRNP H. These results indicate that hnRNP H participates in exclusion of exon 7 in nonmuscle cells. The involvement of hnRNP H in the activity of an ESS may represent a prototype for the regulation of tissue- and developmental-specific alternative splicing.  (+info)

Amphidinolide B, a powerful activator of actomyosin ATPase enhances skeletal muscle contraction. (5/1370)

Amphidinolide B caused a concentration-dependent increase in the contractile force of skeletal muscle skinned fibers. The concentration-contractile response curve for external Ca2+ was shifted to the left in a parallel manner, suggesting an increase in Ca2+ sensitivity. Amphidinolide B stimulated the superprecipitation of natural actomyosin. The maximum response of natural actomyosin to Ca2+ in superprecipitation was enhanced by it. Amphidinolide B increased the ATPase activity of myofibrils and natural actomyosin. The ATPase activity of actomyosin reconstituted from actin and myosin was enhanced in a concentration-dependent manner in the presence or absence of troponin-tropomyosin complex. Ca2+-, K+-EDTA- or Mg2+-ATPase of myosin was not affected by amphidinolide B. These results suggest that amphidinolide B enhances an interaction of actin and myosin directly and increases Ca2+ sensitivity of the contractile apparatus mediated through troponin-tropomyosin system, resulting in an increase in the ATPase activity of actomyosin and thus enhances the contractile response of myofilament.  (+info)

Aldolase binding to actin-containing filaments. Formation of paracrystals. (6/1370)

Electron-microscopy observation show that when aldolase binds to F-actin or F-actin-tropomyosin, highly ordered paracrystalline structures are formed consisting of tightly packed filament bundles cross-banded at 36 nm intervals. Morphologically different paracrystalline arrays are formed between aldolase and F-actin-tropomyosin-troponin. The filament bundles are far more extensive and are characterized by a prominent cross-striation at 38nm intervals. It is suggested that this reflects an interaction between troponin and aldolase.  (+info)

Exonic splicing enhancers contribute to the use of both 3' and 5' splice site usage of rat beta-tropomyosin pre-mRNA. (7/1370)

The rat beta-tropomyosin gene encodes two tissue-specific isoforms that contain the internal, mutually exclusive exons 6 (nonmuscle/smooth muscle) and 7 (skeletal muscle). We previously demonstrated that the 3' splice site of exon 6 can be activated by introducing a 9-nt polyuridine tract at its 3' splice site, or by strengthening the 5' splice site to a U1 consensus binding site, or by joining exon 6 to the downstream common exon 8. Examination of sequences within exons 6 and 8 revealed the presence of two purine-rich motifs in exon 6 and three purine-rich motifs in exon 8 that could potentially represent exonic splicing enhancers (ESEs). In this report we carried out substitution mutagenesis of these elements and show that some of them play a critical role in the splice site usage of exon 6 in vitro and in vivo. Using UV crosslinking, we have identified SF2/ASF as one of the cellular factors that binds to these motifs. Furthermore, we show that substrates that have mutated ESEs are blocked prior to A-complex formation, supporting a role for SF2/ASF binding to the ESEs during the commitment step in splicing. Using pre-mRNA substrates containing exons 5 through 8, we show that the ESEs within exon 6 also play a role in cooperation between the 3' and 5' splice sites flanking this exon. The splicing of exon 6 to 8 (i.e., 5' splice site usage of exon 6) was enhanced with pre-mRNAs containing either the polyuridine tract in the 3' splice site or consensus sequence in the 5' splice site around exon 6. We show that the ESEs in exon 6 are required for this effect. However, the ESEs are not required when both the polyuridine and consensus splice site sequences around exon 6 were present in the same pre-mRNA. These results support and extend the exon-definition hypothesis and demonstrate that sequences at the 3' splice site can facilitate use of a downstream 5' splice site. In addition, the data support the hypothesis that ESEs can compensate for weak splice sites, such as those found in alternatively spliced exons, thereby providing a target for regulation.  (+info)

Regulatory protein of vascular smooth muscle. (8/1370)

Preparations of native tropomyosin from the muscles of bovine aorta and carotid artery resensitized myosin B from either tissue. Neither preparation had any effect on desensitized myosin B from skeletal muscle but native tropomyosin from skeletal muscle could resensitize desensitized myosin B from vascular smooth muscles.  (+info)

Tropomyosin
Tropomyosin is a rod-shaped molecule composed of two intertwined polypeptides with a length approximately equal to that of seven actin molecules. Chains of tropomyosin molecules are arranged end to end along the actin thin filament. These tropomyosin molecules partially cover the myosin-binding site on each actin molecule, thereby preventing the cross-bridges from making contact with actin. Each tropomyosin molecule is held in this blocking position by troponin, a smaller, globular protein that is bound to both tropomyosin and actin. One molecule of troponin binds to each molecule of tropomyosin and regulates the access to myosin-binding sites on the seven actin molecules in contact with tropomyosin. This is the status of a resting muscle fiber; troponin and tropomyosin cooperatively block the interaction of cross-bridges with the thin filament. ...
http://science-naturalphenomena.blogspot.com/2012/03/tropomyosin.html
Differential regulation of tropomyosin isoform organization and gene expression in response to altered actin gene expression. |...Differential regulation of tropomyosin isoform organization and gene expression in response to altered actin gene expression. |...
Phenotypically altered C2 myoblast cells, generated by the stable transfection of human nonmuscle actin genes (Schevzov, G., C. Lloyd, and P. Gunning. 1992. J. Cell Biol. 117:775-786), exhibit a differential pattern of tropomyosin cellular organization and isoform gene expression. The beta-actin transfectants displaying a threefold increase in the cell surface area, showed no significant changes in the pattern of organization of the high M(r) tropomyosin isoform, Tm 2, or the low M(r) tropomyosin isoform, Tm 5. In contrast, the gamma- and beta sm-actin gene transfectants, exhibiting a twofold decrease in the cell surface area, had an altered organization of Tm 2 but not Tm 5. In these actin transfectants, Tm 2 did not preferentially segregate into stress fiber-like structures and the intensity of staining was greatly diminished. Conversely, a well-defined stress fiber-like organization of Tm 5 was observed. The pattern of organization of these tropomyosin isoforms correlated with their ...
https://rupress.org/jcb/article/121/4/811/56253/Differential-regulation-of-tropomyosin-isoform
Tropomyosin - WikipediaTropomyosin - Wikipedia
Tropomyosin is a two-stranded alpha-helical coiled coil protein found in cell cytoskeletons. All organisms contain structures that provide physical integrity to their cells. These structures are collectively known as the cytoskeleton, and one of the most ancient systems is based on filamentous polymers of the protein actin. A second polymer of the protein, tropomyosin, is an integral part of most actin filaments in animals. Tropomyosins are a large family of integral components of actin filaments that play a critical role in regulating the function of actin filaments in both muscle and nonmuscle cells. These proteins consist of rod-shaped coiled-coil hetero- or homo-dimers that lie along the α-helical groove of most actin filaments. Interaction occurs along the length of the actin filament, with dimers aligning in a head-to-tail fashion. Tropomyosins are often categorised into two groups, muscle tropomyosin isoforms and nonmuscle tropomyosin isoforms. Muscle tropomyosin isoforms are involved in ...
https://en.wikipedia.org/wiki/Tropomyosin
AID 590850 - Binding affinity to chicken skeletal muscle tropomyosin within actomyosin protein complex at 125 uM after 1 hr...AID 590850 - Binding affinity to chicken skeletal muscle tropomyosin within actomyosin protein complex at 125 uM after 1 hr...
BioAssay record AID 590850 submitted by ChEMBL: Binding affinity to chicken skeletal muscle tropomyosin within actomyosin protein complex at 125 uM after 1 hr followed by 10 mins irradiation with UVA by SDS-PAGE analysis using coomassie brilliant blue staining.
https://pubchem.ncbi.nlm.nih.gov/bioassay/590850
Homozygosity for a nonsense mutation in the alpha-tropomyosin gene TPM3 in a patient with severe nemaline myopathy - Murdoch...Homozygosity for a nonsense mutation in the alpha-tropomyosin gene TPM3 in a patient with severe nemaline myopathy - Murdoch...
1997) Homozygosity for a nonsense mutation in the alpha-tropomyosin gene TPM3 in a patient with severe nemaline myopathy. Neuromuscular Disorders, 7 (6-7). pp. 427-428. ...
http://researchrepository.murdoch.edu.au/id/eprint/21750/
Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the...
In myotonic ADR mice that are homozygous for a defect in the muscular chloride channel gene adr/Clc-1, the hyperexcitability of fast muscles is associated with secondary changes in gene expression and fibre type composition, cDNA clones derived from a set of genes down regulated in fast muscles of the myotonic ADR mouse were isolated by a subtractive cloning procedure. A total of 1200 clones were analysed for high expression in fast muscle of wild type and low expression in mutant mouse. Differential transcript levels were verified by northern blot hybridizations. The identities of the corresponding transcripts were determined by sequencing as myosin heavy chain IIB, alpha-tropomyosin, troponin C, a Ca2+ ATPase and parvalbumin mRNAs. Of these, mRNAs for parvalbumin and myosin heavy chain IIB were drastically downregulated in myotonic muscle (to < 10% of control). A full length cDNA clone for skeletal muscle alpha-tropomyosin was homologous to the mouse fibroblast tropomyosin isoform 2, except ...
https://pub.uni-bielefeld.de/publication/1643617
Determination of the native subunit pattern of gizzard tropomyosin using antibodies specific to each subunit1
The gizzard tropomyosin molecule is composed of two subunits at 1:1 molar ratio. Best chicken marinades for grilling Possible composites of the tropomyosin
http://goodrecipes.50r.in/determination-of-the-native-subunit-pattern-of-gizzard-tropomyosin-using-antibodies-specific-to-each-subunit1
The Sydney eScholarship Repository: Tropomyosin Regulates Cell Migration during Skin Wound HealingThe Sydney eScholarship Repository: Tropomyosin Regulates Cell Migration during Skin Wound Healing
Precise orchestration of actin polymer into filaments with distinct characteristics of stability, bundling, and branching underpins cell migration. A key regulator of actin filament specialization is the tropomyosin family of actin-associating proteins. This multi-isoform family of proteins assemble into polymers that lie in the major groove of polymerized actin filaments, which in turn determine the association of molecules that control actin filament organization. This suggests that tropomyosins may be important regulators of actin function during physiological processes dependent on cell migration, such as wound healing. We have therefore analyzed the requirement for tropomyosin isoform expression in a mouse model of cutaneous wound healing. We find that mice in which the 9D exon from the TPM3/γTm tropomyosin gene is deleted (γ9D -/-) exhibit a more rapid wound-healing response 7 days after wounding compared with wild-type mice. Accelerated wound healing was not associated with increased ...
https://ses.library.usyd.edu.au/handle/2123/15662
A De Novo Mutation in α-Tropomyosin That Causes Hypertrophic Cardiomyopathy | CirculationA De Novo Mutation in α-Tropomyosin That Causes Hypertrophic Cardiomyopathy | Circulation
We have demonstrated by haplotype analysis that individual II-3 passed a normal copy of the α-tropomyosin gene to an unaffected child (III-4) and, on the same segment of chromosome 15, a mutated copy to another son (III-2), who developed hypertrophic cardiomyopathy. This observation demonstrates that a de novo α-tropomyosin gene mutation, Asp175Asn, occurred in individual III-2, who has hypertrophic cardiomyopathy (Fig 1A⇑). This finding shows conclusively that this mutation alone is sufficient to cause the disease and excludes the possibility that another abnormality in this or a linked gene is responsible. The Asp175Asn mutation in the α-tropomyosin gene of individual III-2 was present in three different tissues: cardiac myocytes, lymphocytes, and gametes. This suggests that the mutation arose either in development of the gamete (ie, during spermatogenesis in the father, II-3) or very early in embryonic development. We cannot determine whether the probands father (individual II-3) ...
http://circ.ahajournals.org/content/91/9/2302
Thermal unfolding of smooth muscle and nonmuscle tropomyosin alpha-homodimers with alternatively spliced exons - Kent Academic...Thermal unfolding of smooth muscle and nonmuscle tropomyosin alpha-homodimers with alternatively spliced exons - Kent Academic...
We used differential scanning calorimetry (DSC) and circular dichroism (CD) to investigate thermal unfolding of recombinant fibroblast isoforms of alpha-tropomyosin (Tm) in comparison with that of smooth muscle Tm. These two nonmuscle Tm isoforms 5a and 5b differ internally only by exons 6b/6a, and they both differ from smooth muscle Tm by the N-terminal exon 1b which replaces the muscle-specific exons 1a and 2a. We show that the presence of exon 1b dramatically decreases the measurable calorimetric enthalpy of the thermal unfolding of Tm observed with DSC, although it has no influence on the alpha-helix content of Tm or on the end-to-end interaction between Tm dimers. The results suggest that a significant part of the molecule of fibroblast Tm (but not smooth muscle Tm) unfolds noncooperatively, with the enthalpy no longer visible in the cooperative thermal transitions measured. On the other hand, both DSC and CD studies show that replacement of muscle exons 1a and 2a by nonmuscle exon 1b not ...
https://kar.kent.ac.uk/13213/
Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain -...Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain -...
In this study we report on the developmental and regional expression of two brain-specific isoforms of tropomyosin, TMBr-1 and TMBr-3, that are generated from the rat alpha-tropomyosin gene via the use of alternative promoters and alternative RNA splicing. Western blot analysis using an exon-specific peptide polyclonal antibody revealed that the two isoforms are differentially expressed in development with TMBr-3 appearing in the embryonic brain at 16 days of gestation, followed by the expression of TMBr-1 at 20 days after birth. TMBr-3 was detected in all brain regions examined, whereas TMBr-1 was detected predominantly in brain areas that derived from the prosencephalon. Immunocytochemical studies on mixed primary cultures made from rat embryonic midbrain indicate that expression of the brain-specific epitope is restricted to neurons. The developmental pattern and neuronal localization of these forms of tropomyosin suggest that these isoforms have a specialized role in the development and ...
https://repository.cshl.edu/id/eprint/32592/
tropomyosin - oi
A protein found in the actin filaments in muscles. The molecule consists of two elongated strands that run along the length of the filament. When the muscle is at rest, the tropomyosin molecule covers the binding site of the actin molecule, where interaction with myosin occurs. On contraction of the muscle, the tropomyosin is displaced by another protein, troponin, allowing the interaction of actin with myosin. See sliding filament theory. ...
http://oxfordindex.oup.com/view/10.1093/oi/authority.20110803105846383
Interaction of aldolase with the troponin-tropomyosin complex of bovine muscle | Biochemical JournalInteraction of aldolase with the troponin-tropomyosin complex of bovine muscle | Biochemical Journal
Ultracentrifugal studies of mixtures of aldolase and the troponin-tropomyosin complex from bovine muscle showed the existence of a labile interaction between these two myofibrillar constituents in imidazole buffers, pH6.8, I 0.02-0.10 (mol/l), and the suppression of the reaction by fructose 1,6-diphosphate. Analysis of the sedimentation-velocity patterns suggests the binding of more than 2 molecules of troponin-tropomyosin/molecule of aldolase. The results illustrate the necessity of considering additional or alternative sites to F-actin to account for the observed binding of aldolase to the thin filaments of skeletal muscle.. ...
http://www.biochemj.org/content/139/3/785
News - FOR2333 Research Unit
In this study, the Ephrussi lab shows that an atypical tropomyosin isoform is a direct (m)RNA binding protein that binds preferentially to the dimerizing oskar 3 UTR and is a component of the transported oskar mRNPs within the female germ-line. In the absence of this tropomyosin isoform, Khc fails to get loaded onto oskar mRNA, which explains the reduced motility and ultimately the failure in oskar localization. This Tm1-I/C dependent recruitment is rather inefficient - only a small fraction of oskar mRNPs acquire Khc - but dynamic, enabling the posterior-ward transport of virtually all oskar mRNPs. Most importantly, however, the Tm1-I/C recruited Khc is inactive. Activation of the motor only commences in the oocyte during mid-oogenesis - possibly to prevent interference with the other transporter of oskar, cytoplasmic dynein - and requires the previously identified exon junction complex (EJC) and associated spliced oskar localization element (SOLE).. Gaspar, I., Sysoev, V., Komissarov, A. and ...
http://for2333.de/news
Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics<...
TY - JOUR. T1 - Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics. AU - Gaffin, Robert D.. AU - Gokulan, Kuppan. AU - Sacchettini, James C.. AU - Hewett, Timothy E.. AU - Klevitsky, Raisa. AU - Robbins, Jeffrey. AU - Sarin, Vandana. AU - Zawieja, David C.. AU - Meininger, Gerald A.. AU - Muthuchamy, Mariappan. PY - 2006. Y1 - 2006. N2 - The ends of striated muscle tropomyosin (TM) are integral for thin filament cooperativity, determining the cooperative unit size and regulating the affinity of TM for actin. We hypothesized that altering the α-TM carboxy terminal overlap end to the β-TM counterpart would affect the amino-terminal association, which would alter the end-to-end interactions of TM molecules in the thin filament regulatory strand and affect the mechanisms of cardiac muscle contraction. To test this hypothesis, we generated transgenic (TG) mouse lines that express a mutant form of α-TM in which the first 275 residues are from α-TM and the last ...
https://mayoclinic.pure.elsevier.com/en/publications/changes-in-end-to-end-interactions-of-tropomyosin-affect-mouse-ca
Localization of myosin, actin, alpha-actinin, tropomyosin and vinculin in surface-activated, spreading human platelets. -...Localization of myosin, actin, alpha-actinin, tropomyosin and vinculin in surface-activated, spreading human platelets. -...
We observed the localization of the contractile proteins myosin, filamentous actin, alpha-actinin, tropomyosin, and vinculin in surface-activated, spreading human platelets using a single fluorescence staining procedure and conventional fluorescence microscopy. Myosin was distributed in a speckled pattern that extended radially from the granulomere. F-actin demonstrated cable-networks. Tropomyosin and alpha-actinin occurred in a punctuate distribution, and vinculin was localized at adhesion sites. Although myosin, F-actin, alpha-actinin, tropomyosin, and vinculin were not studied in resting platelets, our data support the idea that these contractile proteins are reorganized and reassembled in activated platelets during platelet function.
https://www.semanticscholar.org/paper/Localization-of-myosin-actin-alpha-actinin-tropomy-Takubo-Hino/c8ef866425fb81f18722651b84679a682d29a2a9
Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells - Kubo - 2012 -...Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells - Kubo - 2012 -...
Injury to lens epithelial cells (LECs) leads to epithelial-mesenchymal transition (EMT) with resultant fibrosis. The tropomyosin (Tpm) family of cytoskeleton proteins is involved in regulating and stabilizing actin microfilaments. Aberrant expression of Tpms leads to abnormal morphological changes with disintegration of epithelial integrity. The EMT of LECs has been proposed as a major cause of posterior capsule opacification (PCO) after cataract surgery. Using in vivo rodent PCO and human cataractous LECs, we demonstrated that the aberrant expression of rat Tpm and human Tpm1α/2β suggested their association in remodelling of the actin cytoskeleton during EMT of LECs. Expression analysis from abnormally growing LECs after lens extraction revealed elevated expression of α-smooth muscle actin (α-SMA), a marker for EMT. Importantly, these cells displayed increased expression of Tpm1α/2β following EMT/PCO formation. Expression of Tpm1α/2β was up-regulated in LECs isolated from cataractous ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01654.x/abstract?globalMessage=0
HKU Scholars Hub: Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one...HKU Scholars Hub: Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one...
The one-bead-one-compound (OBOC) combinatorial peptide library is a powerful tool to identify ligand and receptor interactions. Here, we applied the OBOC library technology to identify mimotopes specific to the immunoglobulin E (IgE) epitopes of the major shellfish allergen tropomyosin. OBOC peptide libraries with 8-12 amino acid residues were screened with serum samples from patients with shellfish allergy for IgE mimotopes of tropomyosin. Twenty-five mimotopes were identified from the screening and their binding reactivity to tropomyosin-specific IgE was confirmed by peptide ELISA. These mimotopes could be divided into seven clusters based on sequence homology, and epitope mapping by EpiSearch of the clustered mimotopes was performed to characterize and confirm the validity of mimotopes. Five out of six of the predicted epitopes were found to overlap with previously identified epitopes of tropomyosin. To further confirm the mimicry potential of mimotopes, BALB/c mice were immunized with ...
http://hub.hku.hk/handle/10722/223228
User:Z3367632 - CellBiologyUser:Z3367632 - CellBiology
Part A 1.) What are the changes in phenotypes that you observe between group A and group B? In group A, in which Tropomyosin 4 was over-expressed, the stringed phenotype was the most common among the cells observed. In the control group (group B) the pronged phenotype was the most common. 2.) How does Tm4 mediate these changes? Tm4 mediates these changes due to its effect on actin filaments within the cells. Tropomyosin, of which Tm4 is an isoform, is a protein that binds to actin filaments and promotes their stability. Actin filaments are important structural components of neurites, which are projections of the cell body of the neuron. [2] Due to the overexpression of the tropomyosin isoform in group A the higher percentage of cells with the stringed phenotype makes sense. The greater expression of tropomyosin means that there is a higher level of stabilized actin filaments, which would explain the presence of more cells with long neurites than the control group. The lower levels of ...
https://cellbiology.med.unsw.edu.au/cellbiology/index.php/User:Z3367632
Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation...
Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease, which affects the structure of heart muscle tissue. The clinical symptoms include arrhythmias, progressive heart failure, and even sudden cardiac death but the mutation carrier can also be totally asymptomatic. To date, over 1400 mutations have been linked to HCM, mostly in genes encoding for sarcomeric proteins. However, the pathophysiological mechanisms of the disease are still largely unknown. Two founder mutations for HCM in Finland are located in myosin-binding protein C (MYBPC3-Gln1061X) and α-tropomyosin (TPM1-Asp175Asn) genes. We studied the properties of HCM cardiomyocytes (CMs) derived from patient-specific human induced pluripotent stem cells (hiPSCs) carrying either MYBPC3-Gln1061X or TPM1-Asp175Asn mutation. Both types of HCM-CMs displayed pathological phenotype of HCM but, more importantly, we found differences between CMs carrying either MYBPC3-Gln1061X or TPM1-Asp175Asn gene mutation in their cellular size, Ca2+ ...
http://tampub.uta.fi/handle/10024/98826
Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics -...
Fingerprint Dive into the research topics of Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics. Together they form a unique fingerprint. ...
https://arizona.pure.elsevier.com/en/publications/effects-of-cardiomyopathy-linked-mutations-k15n-and-r21h-in-tropo/fingerprints/
Tropomyosin alpha-4 chainTropomyosin alpha-4 chain
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009 ...
https://pharos.nih.gov/idg/targets/P67936
Difference between revisions of 2013 Lab 6 - CellBiologyDifference between revisions of 2013 Lab 6 - CellBiology
The actin microfilaments are composed of a two stranded polymer of actin and most filaments also contain polymers of the rod shaped tropomyosin running along the major groove in the filament. As you heard in the lecture on Microfilaments, the different tropomyosin isoforms have the ability to direct the assembly of specific cellular structures. Previous experiments have been performed in which the neuroblastoma derived cell line, B35 (Schubert D, etal., 1974) is given a gene construct driving the expression of a specific tropomyosin. Cells are then isolated which express the introduced tropomyosin and analysed for changes in phenotype. ...
https://cellbiology.med.unsw.edu.au/cellbiology/index.php?title=2013_Lab_6&diff=44389&oldid=44388
Tropomyosin isoforms in rat neurons: the different developmental profiles and distributions of TM-4 and TMBr-3 are consistent...Tropomyosin isoforms in rat neurons: the different developmental profiles and distributions of TM-4 and TMBr-3 are consistent...
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https://jcs.biologists.org/content/107/10/2961.article-info
C-Terminal Truncation of Cardiac Troponin I Causes Divergent Effects on ATPase and Force | Circulation ResearchC-Terminal Truncation of Cardiac Troponin I Causes Divergent Effects on ATPase and Force | Circulation Research
The data are considered in the context of prominent three-state models of thin-filament regulation. In the biochemical three-state model, advanced by McKillop and Geeves15 and refined by Geeves and Lehrer,33 tropomyosin can exist in equilibrium between three states. In the absence of Ca2+, troponin stabilizes tropomyosin in a state that blocks myosin binding to actin (blocked state). In the presence of Ca2+, the equilibrium shifts and tropomyosin adopts a state that allows myosin to bind strongly to actin (closed state). In the presence of myosin, equilibrium shifts yet again and tropomyosin adopts a state that permits myosin to bind actin, hydrolyze ATP, and cooperatively propagate further binding of myosin to actin (open state). Vibert and colleagues32 have proposed a structural three-state model in which the Ca2+-free troponin constrains tropomyosin in a position on the inner edge of the outer domain of actin that sterically occludes myosin-binding sites (EGTA state). In the presence of Ca2+, ...
http://circres.ahajournals.org/content/93/10/917
Functional Homodimers and Heterodimers of Recombinant Smooth Muscle Tropomyosin †Functional Homodimers and Heterodimers of Recombinant Smooth Muscle Tropomyosin †
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https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_bi0613224
Structural analysis of smooth muscle tropomyosin α and β isoforms. | Sigma-AldrichStructural analysis of smooth muscle tropomyosin α and β isoforms. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Jampani Nageswara Rao, Roland Rivera-Santiago, Xiaochuan Edward Li, William Lehman, Roberto Dominguez].
https://www.sigmaaldrich.com/catalog/papers/22119916
Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states | Journal of General Physiology |...Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states | Journal of General Physiology |...
Although cryo-EM reconstruction is currently the method of choice to resolve macromolecular structure and is optimal for defining troponin-tropomyosin structure and position on actin filaments in specific thin filament end states, it does not readily capture dynamics about those states or transitions between states. Moreover, blotting thin filament samples into thin films before freezing may distort actin-tropomyosin mechanics (Galkin et al., 2012), and in addition, minimal hydration ensuing at or near the air-water interface during preparation (Noble et al., 2018a,b) may distort weak and transient interaction pathways on the actin surface. As an alternative, we therefore have begun to extend understanding beyond high-resolution 3-D EM, by using MD to determine potential energetically favorable pathways between thin filament regulatory states. We had to overcome a number of technical drawbacks inherent to current MD protocols. Most significantly, the size of the actin-tropomyosin complex and the ...
https://rupress.org/jgp/article/151/1/4/54663/Spontaneous-transitions-of-actin-bound-tropomyosin
Items where Subject is bioinformatics | genomics and proteomics | genetics & nucleic acid processing | DNA, RNA structure,...Items where Subject is bioinformatics | genomics and proteomics | genetics & nucleic acid processing | DNA, RNA structure,...
Chen, C. D., Kobayashi, R., Helfman, D. M. (1999) Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene. Genes and Development, 13 (5). pp. 593-606. ISSN 0890-9369 (Print) Chio, I. I. C., Jafarnejad, S. M., Ponz-Sarvise, M., Park, Y., Rivera, K., Palm, W., Ohlund, D., Hammell, M., Crawford, H., Schmidt, E., Thompson, C., Pappin, D., Sonenberg, N., Tuveson, D. (2017) NRF2 promotes tumor maintenance by modulating mRNA translation in pancreatic cancer. Cancer Research, 77 (Supple). ISSN 0008-54721538-7445 Chio, Iok In Christine, Jafarnejad, Seyed Mehdi, Ponz-Sarvise, Mariano, Park, Youngkyu, Rivera, Keith, Palm, Wilhelm, Wilson, John, Sangar, Vineet, Hao, Yuan, Öhlund, Daniel, Wright, Kevin, Filippini, Dea, Lee, Eun Jung, Da Silva, Brandon, Schoepfer, Christina, Wilkinson, John Erby, Buscaglia, Jonathan M, DeNicola, Gina M, Tiriac, Herve, Hammell, Molly, Crawford, Howard C, Schmidt, Edward E, Thompson, Craig B, ...
http://repository.cshl.edu/view/subjects/mrna.html
Plus itPlus it
The formation of a neuronal network depends on the proper development and targeting of neurons within the network. Here, we show that Psidin, in a similar manner to its recently described role in oocyte migration, acts as a constituent part of the actin machinery in the context of neuronal circuit formation in vivo. Furthermore, it functionally links to known actin regulators, in particular LimK and nonmuscle Tropomyosin. In addition, we define a novel role of Psidin in cell survival of neurons during development. Our data strongly suggest that Psidin uses two modes of activity. First, it prevents apoptosis of developing olfactory neurons as a noncatalytic subunit of the NatB complex. Second, it regulates axon targeting via its interaction with cytoskeleton regulators. Regarding the first role as part of the NatB complex, our results prove an evolutionarily conserved role of Psidin that has been predicted so far merely on the basis of in silico comparisons (see below) (Brennan et al., ...
http://www.jneurosci.org/content/32/46/16080
Tropomyosin Summary Report | CureHunterTropomyosin Summary Report | CureHunter
Tropomyosin: A protein found in the thin filaments of muscle fibers. It inhibits contraction of the muscle unless its position is modified by TROPONIN.
http://www.curehunter.com/public/keywordSummaryD014335-Tropomyosin.do
Troponin and tropomyosin. | Master Of MedicineTroponin and tropomyosin. | Master Of Medicine
Calcium is released from SR in response to action potential and it binds to troponin C and causes conformational change in Troponin-Tropomyosin -Actin unit, myosin binding sites become uncovered leading to muscle contraction.. ...
http://masterofmedicine.com/troponin-and-tropomyosin/
Tropomyosin 1 genetically constrains in vitro hematopoiesis | BMC Biology | Full TextTropomyosin 1 genetically constrains in vitro hematopoiesis | BMC Biology | Full Text
Identifying causal variants and genes from human genetic studies of hematopoietic traits is important to enumerate basic regulatory mechanisms underlying these traits, and could ultimately augment translational efforts to generate platelets and/or red blood cells in vitro. To identify putative causal genes from these data, we performed computational modeling using available genome-wide association datasets for platelet and red blood cell traits. Our model identified a joint collection of genomic features enriched at established trait associations and plausible candidate variants. Additional studies associating variation at these loci with change in gene expression highlighted Tropomyosin 1 (TPM1) among our top-ranked candidate genes. CRISPR/Cas9-mediated TPM1 knockout in human induced pluripotent stem cells (iPSCs) enhanced hematopoietic progenitor development, increasing total megakaryocyte and erythroid cell yields. Our findings may help explain human genetic associations and identify a novel genetic
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-020-00783-7/figures/5
ReP USP - Detalhe do registro: Purification of native shrimp tropomyosin by affinity chromatography with cross-reactive antibodyReP USP - Detalhe do registro: Purification of native shrimp tropomyosin by affinity chromatography with cross-reactive antibody
WÜNSCHMANN, S.; UCHIDA, M.; LEHRER, S. B.; ARRUDA, Luisa Karla de Paula; CHAPMAN, M. D. Purification of native shrimp tropomyosin by affinity chromatography with cross-reactive antibody. Journal of Allergy and Clinical Immunology[S.l: s.n.], 2010 ...
https://repositorio.usp.br/item/001818544
Gentaur Molecular :Abfron \ anti-Tropomyosin, Mouse monoclonal to Tropomyosin, Isotype IgG1 \ LF-MA41491Gentaur Molecular :Abfron \ anti-Tropomyosin, Mouse monoclonal to Tropomyosin, Isotype IgG1 \ LF-MA41491
Gentaur molecular products has all kinds of products like :search , Abfron \ anti-Tropomyosin, Mouse monoclonal to Tropomyosin, Isotype IgG1 \ LF-MA41491 for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=3042734&supplier=search&name=anti_Tropomyosin,%20Mouse%20monoclonal%20to%20Tropomyosin,%20Isotype%20%20IgG1
CaldesmonCaldesmon
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity ...
https://pharos.nih.gov/idg/targets/Q05682
Biology-Online • View topic - Muscle ContractionsBiology-Online • View topic - Muscle Contractions
The myosin fibers (on actin) are blocked by tropomyosin which is anchored by troponin. Ca2+ binds to troponin causing a conformational change thus moving tropomyosin allowing the myosin binding site to become open. These binding sites form a cross bridge with actin with the help of ADP/Pi. The release of this ADP and phosphate powers a stroke between the myosin and actin filaments causing a pass of the long to shortened sacromere. ADP is released and a new ATP binds to myosin, detacing (relaxing) myosin for next stroke. When ATP is converted to ADP/Pi, another stroke occurs and the cycle repeats until Ca2+ or ATP runs out ...
http://www.biology-online.org/biology-forum/about20727.html?p=129076&hilit=Nerve+impulses
Cardiac muscle regulatory units are predicted to interact stronger than neighboring cross-bridgesCardiac muscle regulatory units are predicted to interact stronger than neighboring cross-bridges
Strong interactions between cross-bridges (XB) and regulatory units (RU) lead to a steep response of cardiac muscle to an increase in intracellular calcium. We developed a model to quantitatively assess the influence of different types of interactions within the sarcomere on the properties of cardiac muscle. In the model, the ensembles consisting of cross-bridge groups connected by elastic tropomyosin are introduced, and their dynamics is described by a set of partial differential equations. Through large scans in the free energy landscape, we demonstrate the different influence of RU-RU, XB-XB, and XB-RU interactions on the cooperativity coefficient of calcium binding, developed maximal force, and calcium sensitivity. The model solution was fitted to reproduce experimental data on force development during isometric contraction, shortening in physiological contraction, and ATP consumption by acto-myosin. On the basis of the fits, we quantified the free energy change introduced through RU-RU and ...
https://sysbio.ioc.ee/publications/papers/cardiac-muscle-regulatory-units-are-predicted-to-interact-stronger-than-neighboring-cross-bridges/
Creating your force regulatory model - UT-Heart XB ModelerCreating your force regulatory model - UT-Heart XB Modeler
You will construct three models in this chapter. These models are provided as sample models with model names tutorial Ca-F regulatory, tutorial SL dependent(0) and tutorial SL dependent(1).. Here you will include the force regulatory unit which responds to the calcium ion concentration [Ca2+] in its force generation. The actin filament is divided into segments which are referred as to the T/T units. Here the first and second Ts represent the troponin and tropomyosin, respectively. The arrangement of the tropomyosin is controlled by the troponin that reacts with calcium ions and changes the configuration of tropomyosin to expose the biding sites. Here you will create the sarcomere model shown below by starting from the sample model tutorial energy aware MH-3.. ...
http://ut-heart.com/tutorial/chapter3-1
Site-Specific Mutations in the Myosin Binding Sites of Actin Affect Structural Transitions That Control Myosin Binding †Site-Specific Mutations in the Myosin Binding Sites of Actin Affect Structural Transitions That Control Myosin Binding †
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https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_bi010893n
Tpm3 - Tropomyosin alpha-3 chain - Rattus norvegicus (Rat) - Tpm3 gene & proteinTpm3 - Tropomyosin alpha-3 chain - Rattus norvegicus (Rat) - Tpm3 gene & protein
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
http://www.uniprot.org/uniprot/Q63610
Calcium Pumps - Stock Video Clip K005/0663 - Science Photo LibraryCalcium Pumps - Stock Video Clip K005/0663 - Science Photo Library
Calcium pumps transport calcium back into sarcoplasmic reticulum, ending an action potential and causing relaxation. The process of muscle contraction will continue until the action potential is terminated. Relaxation is achieved when calcium pumps have actively transported calcium back into the sarcoplasmic reticulum, reversing the changes that previously occurred in troponin. Tropomyosin is now back in its original position covering the myosin binding sites on actin, preventing crossbridges and power stroke cycling. - Stock Video Clip K005/0663
http://www.sciencephoto.com/media/682434/view
Miscellaneous Glutamate - NF-κB signaling in inflammation and cancerMiscellaneous Glutamate - NF-κB signaling in inflammation and cancer
Supplementary MaterialsAdditional file 1: Amount S1. analysis. Desk S2. Individual 15-LOX1 gene methylation level in Wager1A and NCI-H23 cells treated by PM2.5 and NNK. (DOCX 8597 kb) 13046_2019_1380_MOESM1_ESM.docx (8.3M) GUID:?E4D45034-F009-4058-81B1-2C06D29B3D25 Data Availability StatementAll relevant data are contained in the paper and its own supplementary information files. Abstract History Epidemiological observations possess showed that ambient great […]. Read More ». ...
http://healthcarecoremeasures.com/category/miscellaneous-glutamate/
HumanPhysiology2011 - 11. Muscule Physiology
When you contract a muscle, you are shortening sarcomeres that slide between two filaments, one thick and one thin. The sliding is produced by cross bridges that come out from both the myosin and actin. Myosine heads are located on each end of a sarcomere which pulls actin towards the center. The myosine heads split up ATP into ADP and P. After the myosine heads attach to a actin protien it forms a cross bridge causing dephosphorylated making a change in the myosin creating a power stroke. This adds to the force pulling the thin filament towards the center. More cross bridges are made to make the force stronger. Attached to actin is a protein called tropomyosin which then has a protein called tropinin attached to it. They are the switch that controls wheather the muscle is going to contract or relax. In order to relax, tropomyosin has to be removed and it can only be removed by tropinin and Ca2+ working together. Each muscle cells contains a cytoplasm which in turn contains the sarcoplasm. The ...
https://humanphysiology2011.wikispaces.com/11.+Muscule+Physiology?responseToken=087c9008d3bf85cb7407e8c70848ecb8d
Structural Kinetics of Thin Filament Regulation at Single Molecule Level - Wen-Ji DongStructural Kinetics of Thin Filament Regulation at Single Molecule Level - Wen-Ji Dong
Heart failure results from impaired activation or deactivation of the heart at the level of the myofilament. Current dogma suggests that cardiac muscle contract...
http://grantome.com/grant/NIH/R21-HL109693-02
What blocks active sites on the actin when a muscle is at rest? | Reference.comWhat blocks active sites on the actin when a muscle is at rest? | Reference.com
According to the University of New Mexico, regulatory proteins known as troponin and tropomyosin form a complex and block the active sites on actin molecules. The troponin tropomyosin complex...
https://www.reference.com/science/blocks-active-sites-actin-muscle-rest-7ae255a00294d6de
Mechanisms of thin filament assembly in embryonic chick cardiac myocytes: Tropomodulin requires tropomyosin for assembly<...
TY - JOUR. T1 - Mechanisms of thin filament assembly in embryonic chick cardiac myocytes. T2 - Tropomodulin requires tropomyosin for assembly. AU - Gregorio, Carol. AU - Fowler, V. M.. PY - 1995. Y1 - 1995. N2 - Tropomodulin is a pointed end capping protein for tropomyosin-coated actin filaments that is hypothesized to play a role in regulating the precise lengths of striated muscle thin filaments (Fowler, V. M., M. A. Sussman, P. G. Miller, B. E. Flucher, and M. P. Daniels. 1993. J. Cell Biol. 120:411- 420; Weber, A., C. C. Pennise, G. G. Babcock, and V. M. Fowler. 1994. J. Cell Biol. 127:1627-1635). To gain insight into the mechanisms of thin filament assembly and the role of tropomodulin therein, we have characterized the temporal appearance, biosynthesis and mechanisms of assembly of tropomodulin onto the pointed ends of thin filaments during the formation of striated myofibrils in primary embryonic chick cardiomyocyte cultures. Our results demonstrate that tropomodulin is not assembled ...
https://arizona.pure.elsevier.com/en/publications/mechanisms-of-thin-filament-assembly-in-embryonic-chick-cardiac-m
A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy. - Radcliffe Department of...A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy. - Radcliffe Department of...
Nemaline myopathies are diseases characterized by the presence in muscle fibres of pathognomonic rod bodies. These are composed largely of alpha-actinin and actin. We have identified a missense mutation in the alpha-tropomyosin gene, TPM3, which segregates completely with the disease in a family whose autosomal dominant nemaline myopathy we had previously localized to chromosome 1p13-q25. The mutation substitutes an arginine residue for a highly conserved methionine in a putative actin-binding site near the N terminus of the alpha-tropomyosin. The mutation may strengthen tropomyosin - actin binding, leading to rod body formation, by adding a further basic residue to the postulated actin-binding motif.
https://www.rdm.ox.ac.uk/publications/664255
Cold adaptation of Atlantic salmon tropomyosin: role of residue 77 - Memorial University Research RepositoryCold adaptation of Atlantic salmon tropomyosin: role of residue 77 - Memorial University Research Repository
Tropomyosin from the fast skeletal (trunk) muscle of Atlantic salmon (Salmo salar) is an alpha-type isoform. It shares ~93% identity with a counterpart from rabbit skeletal muscle (20 amino acid substitutions out of a total of 284) but is less thermally stable. -- An interesting aspect of the small heterogeneity is the replacement of lysine-77 in rabbit with threonine in salmon. In the case of the mammalian protein, the lysine in question is positioned to form ion pairs with aspartate-80 in the next turn of the same helix and also with glutamate 82 in the opposing helix of the coiled coil. Thus, at neutral pH, salmon tropomyosin loses two potential charge-charge (ion pair) interactions. The contribution of residue-77 to the properties of salmon tropomyosin has been investigated by mutating it to the amino acid in rabbit using site directed mutagenesis, followed by circular dichroism, differential scanning calorimetry, affinity chromatography and limited proteolysis. A major finding of this ...
http://research.library.mun.ca/10716/
Studies on the regulatory complex of rabbit skeletal muscle: Contributions of troponin subunits and tropomyosin in the presence...
TY - JOUR. T1 - Studies on the regulatory complex of rabbit skeletal muscle. T2 - Contributions of troponin subunits and tropomyosin in the presence and absence of Mg2+ to the acto-S1 ATPase activity. AU - Van Eyk, Jennifer E.. AU - Cachia, Paul J.. AU - Ingraham, Richard H.. AU - Hodges, Robert S.. PY - 1986/10/1. Y1 - 1986/10/1. N2 - The regulatory roles of the components of the troponin-tropomyosin complex in the presence and absence of Mg2+ on the acto-S1 ATPase have been examined. The effect of free Mg2+ on the inhibition of the acto-S1 ATPase by rabbit skeletal troponin (Tn) was studied at S1 to actin ratios ranging from 0.17:1 to 2.5:1. These studies were performed using two Mg2+ concentrations: 2.5 mM Mg2+-2.5 mM ATP, conditions considered to have low free Mg2+; and 5.0 mM Mg2+-2.5 mM ATP, conditions providing a high free Mg2+ concentration of ∼2.5 mM. In the presence of high free Mg2+ (2.5 mM ATP-5.0 mM MgCl2) the Tn inhibition of acto-S1-TM ATPase increased by approximately 40-50% ...
https://jhu.pure.elsevier.com/en/publications/studies-on-the-regulatory-complex-of-rabbit-skeletal-muscle-contr-3
Co-transcriptional commitment to alternative splice site selection. - Oxford Neuroscience
Production of mRNA in eukaryotic cells involves not only transcription but also various processing reactions such as splicing. Recent experiments have indicated that there are direct physical connections between components of the transcription and processing machinery, supporting previous suggestions that pre-mRNA splicing occurs co-transcriptionally. Here we have used a novel functional approach to demonstrate co-transcriptional regulation of alternative splicing. Exon 3 of the alpha-tropomyosin gene is specifically repressed in smooth muscle cells. By delaying synthesis of an essential downstream inhibitory element, we show that the decision to splice or repress exon 3 occurs during a limited window of opportunity following transcription, indicating that splice site selection proceeds rapidly after transcription.
https://www.neuroscience.ox.ac.uk/publications/10085
Aberrant movement of β-tropomyosin associated with congenital myopathy causes defective response of myosin heads and actin...
© 2015 Elsevier Inc. Abstract We have investigated the effect of the E41K, R91G, and E139del β-tropomyosin (TM) mutations that cause congenital myopathy on the position of TM and orientation of actin monomers and myosin heads at different mimicked stages of the ATPase cycle in troponin-free ghost muscle fibers by polarized fluorimetry. A multi-step shifting of wild-type TM to the filament center accompanied by an increase in the amount of switched on actin monomers and the strongly bound myosin heads was observed during the ATPase cycle. The R91G mutation shifts TM further towards the inner and outer domains of actin at the strong- and weak-binding stages, respectively. The E139del mutation retains TM near the inner domains, while the E41K mutation captures it near the outer domains. The E41K and R91G mutations can induce the strong binding of myosin heads to actin, when TM is located near the outer domains. The E139del mutation inhibits the amount of strongly bound myosin heads throughout the ATPase
https://www.cardioscience.ox.ac.uk/publications/528061/
Tropomyosin - Haliotis diversicolor (Abalone)Tropomyosin - Haliotis diversicolor (Abalone)
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
https://www.uniprot.org/uniprot/Q9GZ71
An RNA‐binding atypical tropomyosin recruits kinesin‐1 dynamically to oskar mRNPs | The EMBO Journal
Loading of the appropriate transport machinery on mRNPs is critical to achieve correct localization and, consequently, localized translation of the transcript. Although mRNA transport has been extensively studied over the last two decades, the recruitment of plus‐end‐directed kinesin motors to mRNPs and their regulation remains poorly understood (Medioni et al, 2012).. Here, we have shown that the majority of kinesin‐1 motor associated with oskar mRNA is recruited by Tropomyosin1‐I/C, a non‐canonical RNA binding protein, which explains the mislocalization of oskar mRNA when Tm1‐I/C is lacking (Erdelyi et al, 1995; Veeranan‐Karmegam et al, 2016; and this study). We found that this recruitment occurs early in the cytoplasmic life of the mRNA, upon its nucleo‐cytoplasmic export, in the perinuclear cytoplasm of the nurse cells, where dimerization of oskar mRNA molecules via their 3′UTRs commences (Little et al, 2015). Our observations are consistent with an ergonomic ...
http://emboj.embopress.org/content/early/2016/12/27/embj.201696038
Navigate to: Michael RynkiewiczNavigate to: Michael Rynkiewicz
Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX. (2017) Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop. Biochemistry. Aug 8; 56(31):4095-4105. PMID: 28719181.. Rynkiewicz MJ, Fischer S, Lehman W. (2016) The propensity for tropomyosin twisting in the presence and absence of F-actin. Arch Biochem Biophys. 2016 Nov 1; 609:51-58. PMID: 27663225.. Goh BC, Wu H, Rynkiewicz MJ, Schulten K, Seaton BA, McCormack FX. (2016) Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations. Biochemistry. 2016 Jul 5; 55(26):3692-701. PMID: 27324153.. Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. (2016) Tropomyosin diffusion over actin subunits facilitates thin filament assembly. Struct Dyn. 2016 Jan 14; 3(1):012002. PMID: 26798831.. Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S. (2015) Electrostatic ...
http://www.bumc.bu.edu/phys-biophys/people/faculty/rynkiewicz/
Live dynamics of GFP-calponin: isoform-specific modulation of the actin cytoskeleton and autoregulation by C-terminal sequences...Live dynamics of GFP-calponin: isoform-specific modulation of the actin cytoskeleton and autoregulation by C-terminal sequences...
The calponin family of F-actin-, tropomyosin- and calmodulin-binding proteins currently comprises three genetic variants. Their functional roles implicated from in vitro studies include the regulation of actomyosin interactions in smooth muscle cells (h1 calponin), cytoskeletal organisation in non-muscle cells (h2 calponin) and the control of neurite outgrowth (acidic calponin). We have now investigated the effects of calponin (CaP) isoforms and their C-terminal deletion mutants on the actin cytoskeleton by time lapse video microscopy of GFP fusion proteins in living smooth muscle cells and fibroblasts. It is shown that h1 CaP associates with the actin stress fibers in the more central part of the cell, whereas h2 CaP localizes to the ends of stress fibres and in the motile lamellipodial protrusions of spreading cells. Cells expressing h2 CaP spread more efficiently than those expressing h1 CaP and expression of GFP h1 CaP resulted in reduced cell motility in wound healing experiments. Notably, ...
http://jcs.biologists.org/content/113/21/3725
TPM1 - WikipediaTPM1 - Wikipedia
Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene. This gene is a member of the tropomyosin (Tm) family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tm is a 32.7 kDa protein composed of 284 amino acids. Tm is a flexible protein homodimer or heterodimer composed of two alpha-helical chains, which adopt a bent coiled coil conformation to wrap around the seven actin molecules in a functional unit of muscle. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. Human striated muscles express protein from the TPM1 (α-Tm), TPM2 (β-Tm) and TPM3 (γ-Tm) genes, with α-Tm being the predominant isoform in striated muscle. In human cardiac muscle the ratio of α-Tm to β-Tm is roughly 5:1. Tm functions in association with the troponin complex to regulate the calcium-dependent interaction of ...
https://en.wikipedia.org/wiki/TPM1
1 - College Papers Help Online1 - College Papers Help Online
b.Describe the process of the NT release from a somatic neuron.. 1.Action potential arrives at axon terminal. 2.Voltage-gated Ca++ channels are open and Ca++ enters the axon terminal. 3.Ca++ entering causin the NT being released by exocytosis.. 4.Describe the step by step process of excitation-contraction-relaxation for a skeletal muscle cell (starts with NT binds with the receptor on a skeletal muscle cell).. 1.NT binds with the receptor on a skeletal muscle cell. 2.Sodium Na channel is open (ligand-gated channel). 3.Na influx creating action potential 4.Muscle action potential travels down T-tubules. 5.Sarcoplasmic reticulum releases Ca++. 6.Calcium binds to troponin. 7.Binding Calcium to troponin causing tropomyosin to shift and expose myosin binding sites. 8.Myosin binds to actin and myosin head pulls actin filament. 9.ATP binds to myosin head causing myosin to detach from actin. 10.Myosin head is cocking back and the cycle is repeated as long as Ca++ is attached to troponin.. SKELETAL ...
https://youmademydayphotography.com/1-11/
Electron cryomicroscopy shows cardiac thin filament structure -- MEDICA - World Forum for MedicineElectron cryomicroscopy shows cardiac thin filament structure -- MEDICA - World Forum for Medicine
Researchers at Osaka University used electron cryomicroscopy (CryoEM) to image essential cardiac muscle components, known as thin filaments, with unprecedented resolution. They also discovered the mechanism by which these filaments regulate heartbeat via cardiac muscle contractions in the presence or absence of calcium ions by changing their conformations.
https://www.medica-tradefair.com/en/News/Archive/Electron_cryomicroscopy_shows_cardiac_thin_filament_structure
Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses (model 4) - Physiome...Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses (model 4) - Physiome...
All the models are similar in that they are structured around a functional unit of troponin, tropomyosin and actin. Tropomyosin can exist in four states, two permissive or two non-permissive (referring to whether or not the actin sites are available for binding to myosin and hence cross bridge formation). Depending on the model, one or more cross bridges exist, and these are either weakly-bound (non-force generating) or strongly bound (force generating). The paper (cited below) tests the behaviours of the five models of force generation in cardiac myocytes. The first two models provide a baseline of performance for comparison. Models 3 to 5 are developed to incorporate more cooperative mechanisms. From the results of these simulations, which were compared to and consistent with experimental data, it is hypothesised that multiple mechanisms of cooperativity may coexist and contribute to the responses of cardiac muscle. ...
https://models.cellml.org/e/37/rice_winslow_hunter_1999_d.cellml/view
Oalib searchOalib search
Abstract: In this paper the friction and wear characteristics of vinylester and cenosphere reinforced vinylester composites have been investigated under dry sliding conditions, under different applied normal load and sliding speed. Wear tests were carried using pin on a rotating disc under ambient conditions. Tests were conducted at normal loads 10, 30, 50 and 70 N and under sliding velocity of 1.88, 3.14, 4.39 and 5.65 m/s. The results showed that the coefficient of friction decreases with the increase in applied normal load values under dry conditions. On the other hand for pure vinylester specific wear rate increases with increase in applied normal load. However the specific wear rate for 2%, 6%, 10% and 15% cenosphere reinforced vinylester composite decreases with the increase in applied normal load under dry conditions. The results showed that with increase in the applied normal load and sliding speed the coefficient of friction and spe- cific wear rate decreases under dry sliding ...
http://www.oalib.com/search?kw=Akanksha%20Thakur&searchField=authors
KAKEN - Researchers | ABE Toshihiro (10314808)KAKEN - Researchers | ABE Toshihiro (10314808)
Affiliation：山口大,医学部附属病院,助手, Research Field：Digestive surgery,Digestive surgery, Keywords：CGH,食道癌,リンパ節転移,LC-MS,tropomyosin,microarray,proteomics,M,Tropomyosin,マイクロアレイ, # of Research Projects：3, # of Research Products：4
https://nrid.nii.ac.jp/nrid/1000010314808/
MCQ Physiology Muscles Ques. and Answers | Physiology Plus
The muscle protein, which covers the active sites on the actin filament at rest, is: a. Troponin-I b. Troponin-C c. Tropomyosin d. Myosin e. Actinin
http://physiologyplus.com/mcq-physiology-muscles-questions-and-answers/
IJMS | Free Full-Text | Large-scale Models Reveal the Two-component Mechanics of Striated Muscle | NotesIJMS | Free Full-Text | Large-scale Models Reveal the Two-component Mechanics of Striated Muscle | Notes
This paper provides a comprehensive explanation of striated muscle mechanics and contraction on the basis of filament rotations. Helical proteins, particularly the coiled-coils of tropomyosin, myosin and α-actinin, shorten their H-bonds cooperatively and produce torque and filament rotations when the Coulombic net-charge repulsion of their highly charged side-chains is diminished by interaction with ions. The classical
http://www.mdpi.com/1422-0067/9/12/2658/notes
Publications | NCBSPublications | NCBS
Gangadharan B, Sunitha MS, Mukherjee S, Chowdhury RRoy, Haque F, Sekar N, Sowdhamini R, Spudich JA, Mercer JA. 2017. Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region.. Proc Natl Acad Sci U S A. ...
https://www.ncbs.res.in/publications?page=3&%3Bamp%3Bf%5Bauthor%5D=598&%3Bf%5Bauthor%5D=1204&f%5Bauthor%5D=1370
Publications | NCBSPublications | NCBS
Gupte TM, Haque F, Gangadharan B, Sunitha MS, Mukherjee S, Anandhan S, Rani DSelvi, Mukundan N, Jambekar A, Thangaraj K et al.. 2015. Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies.. J Biol Chem. 290(11):7003-15. ...
https://www.ncbs.res.in/publications?page=7&%3Bamp%3Bs=title&%3Bamp%3Bo=asc&%3Bamp%3Bf%5Bauthor%5D=1254&%3Bf%5Bauthor%5D=1470&f%5Bauthor%5D=162
adducin - oi
A membrane skeleton protein (heterodimer) that interacts with a junctional complex that links spectrin assemblies. The complex in the red blood cell consists of tropomyosin and actin with band 4.1 (see band). Adducin probably binds to band 4.1.. [...] ...
http://oxfordindex.oup.com/view/10.1093/oi/authority.20110810104318213
PicoTwist
REGULATION OF RABBIT SKELETAL MUSCLE CONTRACTION .1. BIOCHEMICAL STUDIES OF INTERACTION OF TROPOMYOSIN-TROPONIN COMPLEX WITH ACTIN AND PROTEOLYTIC FRAGMENTS OF MYOSIN ...
http://picotwist.com/index.php?content=biblio&option=DispCited
Recombinant Human TPM4 protein (ab105576) ReferencesRecombinant Human TPM4 protein (ab105576) References
References for Abcams Recombinant Human TPM4 protein (ab105576). Please let us know if you have used this product in your publication
http://www.abcam.com/recombinant-human-tpm4-protein-ab105576-references.html
TropomyosinTropomyosin
... mutations in both the γ-Tropomyosin and β-Tropomyosin genes have been identified. No mutations in the α-Tropomyosin gene have ... Although tropomyosin is sometimes included as an ABP, it is not a true ABP. The tropomyosin dimer has very low affinity for an ... muscle tropomyosin isoforms and nonmuscle tropomyosin isoforms. Muscle tropomyosin isoforms are involved in regulating ... The sorting of Tropomyosin 5NM1/2 mRNA to this location correlated with the expression of the Tropomyosin 5NM1/2 protein. In ...
https://en.wikipedia.org/wiki/Tropomyosin
Tropomyosin kinaseTropomyosin kinase
In enzymology, a tropomyosin kinase (EC 2.7.11.28) is an enzyme that catalyzes the chemical reaction ATP + tropomyosin ⇌ {\ ... tropomyosin O-phosphotransferase. Other names in common use include tropomyosin kinase (phosphorylating), and STK. deBelle I, ... Montgomery K, Mak AS (1984). "In vitro phosphorylation of tropomyosin by a kinase from chicken embryo". J. Biol. Chem. 259 (9 ... Watson MH, Taneja AK, Hodges RS, Mak AS (1988). "Phosphorylation of alpha alpha- and beta beta-tropomyosin and synthetic ...
https://en.wikipedia.org/wiki/Tropomyosin_kinase
Tropomyosin 3Tropomyosin 3
"Entrez Gene: TPM3 tropomyosin 3". Lees-Miller JP, Helfman DM (1992). "The molecular basis for tropomyosin isoform diversity". ... Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene. This gene encodes a member of the ... Martin-Zanca D, Hughes SH, Barbacid M (1986). "A human oncogene formed by the fusion of truncated tropomyosin and protein ... Reinach FC, MacLeod AR (1986). "Tissue-specific expression of the human tropomyosin gene involved in the generation of the trk ...
https://en.wikipedia.org/wiki/Tropomyosin_3
Tropomyosin receptor kinase CTropomyosin receptor kinase C
... (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, ... Kue CS, Kamkaew A, Voon SH, Kiew LV, Chung LY, Burgess K, Lee HB (November 2016). "Tropomyosin Receptor Kinase C Targeted ... October 2015). "An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase ... Another common feature of neurotrophins is that they produce their physiologic effects by means of the tropomyosin receptor ...
https://en.wikipedia.org/wiki/Tropomyosin_receptor_kinase_C
Tropomyosin receptor kinase BTropomyosin receptor kinase B
... (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or ... October 2015). "An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase ... Ohira K, Kumanogoh H, Sahara Y, Homma KJ, Hirai H, Nakamura S, Hayashi M (February 2005). "A truncated tropomyosin-related ... Another common feature of neurotrophins is that they produce their physiologic effects by means of the tropomyosin receptor ...
https://en.wikipedia.org/wiki/Tropomyosin_receptor_kinase_B
Tropomyosin receptor kinase ATropomyosin receptor kinase A
Shi H, Zhu S, Qin B, Wang L, Yang J, Lu G, Dai F (December 2019). "Nerve growth factor and Tropomyosin receptor kinase A are ... Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase ... Stoleru B, Popescu A, Tache D, Neamtu O, Emami G, Tataranu L, Buteica A, Dricu A, Purcaru S (2013). "Tropomyosin-Receptor- ... Martin-Zanca D, Hughes SH, Barbacid M (April 1986). "A human oncogene formed by the fusion of truncated tropomyosin and protein ...
https://en.wikipedia.org/wiki/Tropomyosin_receptor_kinase_A
D66 strain of Chlamydomonas reinhardtiiD66 strain of Chlamydomonas reinhardtii
... adding tropomyosin; varying light conditions; and varying temperature. The results of these studies showed that the D66 strain ...
https://en.wikipedia.org/wiki/D66_strain_of_Chlamydomonas_reinhardtii
Calponin 2Calponin 2
Calponin also binds tropomyosin, tubulin, desmin, Ca2+-calmodulin, Ca2+-S100, myosin, and phospholipids. Calponin also ... Childs TJ, Watson MH, Novy RE, Lin JJ, Mak AS (1992). "Calponin and tropomyosin interactions". Biochimica et Biophysica Acta ( ... interaction with tropomyosin paracrystals". Journal of Hypertension Supplement. 6 (4): S40-3. doi:10.1097/00004872-198812040- ...
https://en.wikipedia.org/wiki/Calponin_2
Tropomodulin 1Tropomodulin 1
... a tropomyosin isoform encoded by the gamma-tropomyosin gene". Biochem. Biophys. Res. Commun. 201 (2): 627-34. doi:10.1006/bbrc. ... A tropomyosin-binding protein". J Biol Chem. 267 (4): 2616-21. doi:10.1016/S0021-9258(18)45926-1. PMID 1370827. Sung LA, Fan Y ... 2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int. J. ... Vera C, Lao J, Hamelberg D, Sung LA (2006). "Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: ...
https://en.wikipedia.org/wiki/Tropomodulin_1
MYH13MYH13
Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221-30. PMC 1886840. PMID 8424456. v t e (Articles with short ...
https://en.wikipedia.org/wiki/MYH13
Shellfish allergyShellfish allergy
... in that skin tests confirming dust mite allergy were also positive for shellfish tropomyosin. In addition to tropomyosin, ... Tropomyosin, the major allergen in shellfish allergy, is also found in dust mites and cockroaches. Exposure to inhaled ... Tropomyosin, arginine kinase, myosin light chain and sarcoplasmic calcium-binding protein are widely present across shellfish ... The immune system overreacts to proteins found in shellfish, most commonly to tropomyosin, but often to other proteins, such as ...
https://en.wikipedia.org/wiki/Shellfish_allergy
Myosin-11Myosin-11
Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221-30. PMC 1886840. PMID 8424456. New L, Jiang Y, Zhao M, et ...
https://en.wikipedia.org/wiki/Myosin-11
MYH9MYH9
Other proteins that are known to interact with NM IIA include the actin binding protein tropomyosin 4.2 and a novel actin ... Actin, desmin, myosin, and tropomyosin". The American Journal of Pathology. 142 (1): 221-30. PMC 1886840. PMID 8424456. Lalwani ... "Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2". Scientific Reports. 6: 20554. Bibcode:2016NatSR ...
https://en.wikipedia.org/wiki/MYH9
MYH10MYH10
Actin, desmin, myosin, and tropomyosin". The American Journal of Pathology. 142 (1): 221-30. PMC 1886840. PMID 8424456. ... contraction is activated through thin filament proteins troponin and tropomyosin, whereas in NM-IIB and smooth muscle myosin, ...
https://en.wikipedia.org/wiki/MYH10
TPM4TPM4
Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene. GRCh38: Ensembl release 89: ENSG00000167460 ... "Entrez Gene: TPM4 tropomyosin 4". Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded ... Wilton SD, Lim L, Dorosz SD, Gunn HC, Eyre HJ, Callen DF, Laing NG (Jul 1996). "Assignment of the human alpha-tropomyosin gene ... 1986). "A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism". Proc ...
https://en.wikipedia.org/wiki/TPM4
MYH14MYH14
Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221-30. PMC 1886840. PMID 8424456. Xu XR, Huang J, Xu ZG, et ...
https://en.wikipedia.org/wiki/MYH14
MYH6MYH6
An accepted mechanism for this process is that ADP-bound myosin attaches to actin while thrusting tropomyosin inwards, then the ... Actin, desmin, myosin, and tropomyosin". The American Journal of Pathology. 142 (1): 221-30. PMC 1886840. PMID 8424456. Nakao K ...
https://en.wikipedia.org/wiki/MYH6
Beta-actinBeta-actin
Gunning P, Weinberger R, Jeffrey P (Apr 1997). "Actin and tropomyosin isoforms in morphogenesis". Anatomy and Embryology. 195 ( ...
https://en.wikipedia.org/wiki/Beta-actin
TPM1TPM1
Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene. This gene is a member of the tropomyosin (Tm ... Perry SV (2004). "What is the role of tropomyosin in the regulation of muscle contraction?". J. Muscle Res. Cell. Motil. 24 (8 ... Cho YJ, Liu J, Hitchcock-DeGregori SE (1990). "The amino terminus of muscle tropomyosin is a major determinant for function". J ... 1988). "Evolution of tropomyosin functional domains: differential splicing and genomic constraints". J. Mol. Evol. 27 (3): 228- ...
https://en.wikipedia.org/wiki/TPM1
Troponin C type 1Troponin C type 1
The IT arm is anchored to tropomyosin via adjacent segments of cTnT, so it is believed to move as a unit along with tropomyosin ... Tripet B, Van Eyk JE, Hodges RS (Sep 1997). "Mapping of a second actin-tropomyosin and a second troponin C binding site within ... von der Ecken J, Müller M, Lehman W, Manstein DJ, Penczek PA, Raunser S (Mar 2015). "Structure of the F-actin-tropomyosin ... The availability of cTnI148-159 depends on the blocked-closed-open equilibrium of tropomyosin on actin, which can be impacted ...
https://en.wikipedia.org/wiki/Troponin_C_type_1
NebuletteNebulette
... tropomyosin, alpha-actinin. Xin, and XIRP2. Nebulette was identified in 1995 by Moncman and Wang using primary cultures of ... depressed beating frequencies and loss of thin filament regulatory proteins troponin I and tropomyosin. Mutations in the NEBL ... "The nebulette repeat domain is necessary for proper maintenance of tropomyosin with the cardiac sarcomere". Experimental Cell ...
https://en.wikipedia.org/wiki/Nebulette
ActinActin
The helical F-actin filament found in muscles also contains a tropomyosin molecule, which is a 40 nanometre long protein that ... At times of rest, the proteins tropomyosin and troponin bind to the actin filaments, preventing the attachment of myosin. When ... During the resting phase the tropomyosin covers the actin's active sites so that the actin-myosin interaction cannot take place ... There are other protein molecules bound to the tropomyosin thread, these are the troponins that have three polymers: troponin I ...
https://en.wikipedia.org/wiki/Actin
ANA-12ANA-12
Tropomyosin receptor kinase B § Antagonists Cazorla, Maxime; Prémont, Joël; Mann, Andre; Girard, Nicolas; Kellendonk, Christoph ... tropomyosin-related kinase B in hippocampus of obesity-induced hypertensive rats". Int Heart J. 56 (1): 110-5. doi:10.1536/ihj. ...
https://en.wikipedia.org/wiki/ANA-12
Leucine zipperLeucine zipper
Hodges RS, Sodek J, Smillie LB, Jurasek L (1973). "Tropomyosin: Amino Acid Sequence and Coiled-Coil Structure". Cold Spring ...
https://en.wikipedia.org/wiki/Leucine_zipper
Setsuro EbashiSetsuro Ebashi
Ebashi, S; Kodama, A (1965). "A new protein factor promoting aggregation of tropomyosin". Journal of Biochemistry. 58 (1): 107- ...
https://en.wikipedia.org/wiki/Setsuro_Ebashi
HIOCHIOC
Tropomyosin receptor kinase B § Agonists Longo, Frank M.; Massa, Stephen M. (2013). "Small-molecule modulation of neurotrophin ...
https://en.wikipedia.org/wiki/HIOC
Cofilin-2Cofilin-2
Ono S, Ono K (March 2002). "Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics". J. Cell Biol. 156 (6): 1065-76 ...
https://en.wikipedia.org/wiki/Cofilin-2
Nerve growth factorNerve growth factor
The tropomyosin receptor kinase A receptor has five extracellular domains, and the fifth domain is sufficient in binding NGF. ... NGF can drive the expression of genes such as bcl-2 by binding to the Tropomyosin receptor kinase A, which stimulates the ... NGF binds with at least two classes of receptors: the tropomyosin receptor kinase A (TrkA) and low-affinity NGF receptor (LNGFR ... Stoleru B, Popescu A, Tache D, Neamtu O, Emami G, Tataranu L, Buteica A, Dricu A, Purcaru S (2013). "Tropomyosin-Receptor- ...
https://en.wikipedia.org/wiki/Nerve_growth_factor
Trk receptorTrk receptor
The oncogene was generated by a mutation in chromosome 1 that resulted in the fusion of the first seven exons of tropomyosin to ... Normal Trk receptors do not contain amino acid or DNA sequences related to tropomyosin. The three most common types of trk ... Stoleru B, Popescu A, Tache D, Neamtu O, Emami G, Tataranu L, Buteica A, Dricu A, Purcaru S (2013). "Tropomyosin-Receptor- ... Martin-Zanca D, Hughes SH, Barbacid M (1986). "A human oncogene formed by the fusion of truncated tropomyosin and protein ...
https://en.wikipedia.org/wiki/Trk_receptor
Squid as foodSquid as food
As with other molluscs, the allergen is probably tropomyosin. Chinese-style fried baby squid Japanese Ikameshi Japanese Ika ...
https://en.wikipedia.org/wiki/Squid_as_food
Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene. | HeartClinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene. | Heart
Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene. ... Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene. ... Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene. ...
https://heart.bmj.com/content/76/1/63.info
ENZYME - 2.7.11.28 tropomyosin kinaseENZYME - 2.7.11.28 tropomyosin kinase
Phosphorylates casein equally well, and histone and phosvitin to a lesser extent ...
https://enzyme.expasy.org/EC/2.7.11.28
How Does Tropomyosin Control Muscle Contraction?
What is tropomyosin made of?. Tropomyosin (TM) is an actin restrictive protein which consists of a coiled-coil dimer (see left ... What is tropomyosin role in muscle contraction?. Calcium is required by two proteins troponin and tropomyosin that methodize ... What does tropomyosin and troponin do?. Tropomyosin and troponin hinder myosin engage restrictive to actin briefly the muscle ... Does tropomyosin bind to myosin?. Tropomyosin blocks myosin restrictive sites on actin molecules preventing cross-bridge shape ...
https://sahmy.com/how-does-tropomyosin-control-muscle-contraction
Molecular and physiological effects of α-tropomyosin ablation in the mouse<...
N2 - Tropomyosin (TM) is an integral component of the thin filament in muscle fibers and is involved in regulating actin-myosin ... AB - Tropomyosin (TM) is an integral component of the thin filament in muscle fibers and is involved in regulating actin-myosin ... Tropomyosin (TM) is an integral component of the thin filament in muscle fibers and is involved in regulating actin-myosin ... abstract = "Tropomyosin (TM) is an integral component of the thin filament in muscle fibers and is involved in regulating actin ...
https://mayoclinic.pure.elsevier.com/en/publications/molecular-and-physiological-effects-of-%CE%B1-tropomyosin-ablation-in-
α-tropomyosin gene (TPM3) mutation in an infant with nemaline myopathy by Sulaiman Almobarak, Jonathan Hu et al."α-tropomyosin gene (TPM3) mutation in an infant with nemaline myopathy" by Sulaiman Almobarak, Jonathan Hu et al.
We report a case of neonatal nemaline myopathy with a de novo TPM3 mutation, which has been classified as a likely pathogenic mutation. With the expanding use of genetic testing in congenital myopathies, genotype-phenotype descriptions of novel variants are important to inform clinical care, diagnosis, genetic counseling, and management of disease.
https://ir.lib.uwo.ca/paedpub/2742/
Tropomyosin | Colorado PROFILES
"Tropomyosin" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Tropomyosin" by people in this website by year, and whether " ... Transmission of stability information through the N-domain of tropomyosin is interrupted by a stabilizing mutation (A109L) in ... Myofibril-inducing RNA (MIR) is essential for tropomyosin expression and myofibrillogenesis in axolotl hearts. J Biomed Sci. ...
https://profiles.ucdenver.edu/display/209771
Actin, alpha-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells. |...Actin, alpha-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells. |...
... and tropomyosin indicate that this network is composed of foci containing actin and alpha-actinin, connected by tropomyosin- ... stimulation of actin binding of nonmuscle tropomyosin and periodic localization along microfilaments like tropomyosin. ... Differential localization of tropomyosin isoforms in cultured nonmuscle cells. Characterization of 83-kilodalton nonmuscle ... Actin, alpha-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells. E ...
https://rupress.org/jcb/article/68/2/202/18623/Actin-alpha-actinin-and-tropomyosin-interaction-in
l-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish | Journal of Biomedical...l-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish | Journal of Biomedical...
A de novo mutation in Tropomyosin 3-TPM3(E151G) was identified from a boy diagnosed with CM, previously TPM3(E151A) was ... tropomyosin interacts with the troponin complex to regulate actin-myosin interaction. Mutations of tropomyosin 3 (TPM3) cause ... et al. l-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. J Biomed Sci 28, 8 ... l-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. *Po-Jui Hsu1,2,3 na1, ...
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-020-00707-1
Evolutionarily conserved surface residues constitute actin binding sites of tropomyosin - Fingerprint - Rutgers, The State...Evolutionarily conserved surface residues constitute actin binding sites of tropomyosin - Fingerprint - Rutgers, The State...
Evolutionarily conserved surface residues constitute actin binding sites of tropomyosin. Bipasha Barua, Melissa C. Pamula, ... Dive into the research topics of Evolutionarily conserved surface residues constitute actin binding sites of tropomyosin. ...
https://www.researchwithrutgers.com/en/publications/evolutionarily-conserved-surface-residues-constitute-actin-bindin/fingerprints/
Cap myopathy: MedlinePlus GeneticsCap myopathy: MedlinePlus Genetics
Tropomyosin. proteins regulate muscle contraction by attaching to actin and controlling its binding to myosin. The specific ... The TPM2 and TPM3 genes provide instructions for making proteins that are members of the tropomyosin protein family. ... Cap disease due to mutation of the beta-tropomyosin gene (TPM2). Neuromuscul Disord. 2009 May;19(5):348-51. doi: 10.1016/j.nmd. ... Cap disease caused by heterozygous deletion of the beta-tropomyosin gene TPM2. Neuromuscul Disord. 2007 Jun;17(6):433-42. doi: ...
https://medlineplus.gov/genetics/condition/cap-myopathy
Food AllergyFood Allergy
Tropomyosin. 65-70. ≥50. Animals. β-parvalbumin 2S. 12. ≥53. Fish. Seed storage proteins. 2S albumin. 9.5-20. 18-40. Kernels, ...
https://www.medscape.com/viewarticle/809927_3
Tropomyosin α Rabbit Polyclonal Antibody - Lifchem Fine Chemicals Co., LtdTropomyosin α Rabbit Polyclonal Antibody - Lifchem Fine Chemicals Co., Ltd
Description: A polyclonal antibody for detection of Tropomyosin Alpha from Human, Mouse, Rat. This Tropomyosin Alpha antibody ... Description: A polyclonal antibody for detection of Tropomyosin Alpha from Human, Mouse, Rat. This Tropomyosin Alpha antibody ... Description: A polyclonal antibody for detection of Tropomyosin Alpha from Human, Mouse, Rat. This Tropomyosin Alpha antibody ... Description: A polyclonal antibody for detection of Tropomyosin Alpha from Human, Mouse, Rat. This Tropomyosin Alpha antibody ...
http://www.lifchem.com/tropomyosin-%CE%B1-rabbit-polyclonal-antibody/
Tropomyosin α Rabbit Polyclonal Antibody - Cotinis the genus of scarab beetlesTropomyosin α Rabbit Polyclonal Antibody - Cotinis the genus of scarab beetles
Tropomyosin α Rabbit Polyclonal Antibody. To Order: [email protected] Tropomyosin ? Polyclonal Antibody. ... Description: A polyclonal antibody for detection of Tropomyosin Alpha from Human, Mouse, Rat. This Tropomyosin Alpha antibody ... Description: A polyclonal antibody for detection of Tropomyosin Alpha from Human, Mouse, Rat. This Tropomyosin Alpha antibody ... Description: A polyclonal antibody for detection of Tropomyosin Alpha from Human, Mouse, Rat. This Tropomyosin Alpha antibody ...
https://cotinis.com/tropomyosin-%CE%B1-rabbit-polyclonal-antibody/
Congenital fibre type disproportion associated with mutations in the tropomyosin 3 (TPM3) gene mimicking congenital myasthenia ...
Congenital fibre type disproportion associated with mutations in the tropomyosin 3 (TPM3) gene mimicking congenital myasthenia ... Congenital fibre type disproportion associated with mutations in the tropomyosin 3 (TPM3) gene mimicking congenital myasthenia ...
https://www.ndcn.ox.ac.uk/publications/241175
Hypertrophic and dilated cardiomyopathycausing mutations of troponin and alpha-tropomyosin have opposite effects on thin...
Hypertrophic and dilated cardiomyopathycausing mutations of troponin and alpha-tropomyosin have opposite effects on thin ... Hypertrophic and dilated cardiomyopathycausing mutations of troponin and alpha-tropomyosin have opposite effects on thin ...
https://www.well.ox.ac.uk/publications/104354
Binding of troponin-T fragments to several types of tropomyosin. Sensitivity to Ca2+ in the presence of troponin-C - WikidataBinding of troponin-T fragments to several types of tropomyosin. Sensitivity to Ca2+ in the presence of troponin-C - Wikidata
Binding of troponin-T fragments to several types of tropomyosin. Sensitivity to Ca2+ in the presence of troponin-C (English) ... Binding of troponin-T fragments to several types of tropomyosin. Sensitivity to Ca2+ in the presence of troponin-C. scientific ...
https://m.wikidata.org/wiki/Q70429620
Neutrophilia: Overview, Causes, Development of NeutrophilsNeutrophilia: Overview, Causes, Development of Neutrophils
Tropomyosin In addition to many components common to all cells, approximately 45% of the neutrophil cytosolic protein is ...
https://emedicine.medscape.com/article/208576-overview
What Is The Role Of Tropomyosin In Skeletal Muscles - My Cool ClipsWhat Is The Role Of Tropomyosin In Skeletal Muscles - My Cool Clips
What Is The Role Of Tropomyosin In A Skeleton? - Study.com. 25/01/2022 · Tropomyosin is one of many proteins involved in ... If you are looking for what is the role of tropomyosin in skeletal muscles ? Then, this is the place where you can find some ... what is the role of tropomyosin in skeletal muscles Skeletal Muscle: A Brief Review Of Structure And Function. 08/10/2014 · ... I hope the above sources help you with the information related to what is the role of tropomyosin in skeletal muscles . If not ...
https://mycoolclips.com/what-is-the-role-of-tropomyosin-in-skeletal-muscles/
Physiological consequences of tropomyosin mutations associated with cardiac and skeletal myopathies<...Physiological consequences of tropomyosin mutations associated with cardiac and skeletal myopathies<...
Physiological consequences of tropomyosin mutations associated with cardiac and skeletal myopathies. Daniel E. Michele, Joseph ... Physiological consequences of tropomyosin mutations associated with cardiac and skeletal myopathies. / Michele, Daniel E.; ... Physiological consequences of tropomyosin mutations associated with cardiac and skeletal myopathies. Journal of Molecular ... Michele, D. E., & Metzger, J. M. (2000). Physiological consequences of tropomyosin mutations associated with cardiac and ...
https://experts.umn.edu/en/publications/physiological-consequences-of-tropomyosin-mutations-associated-wi
Food Safety Research Projects Database Search | National Agricultural LibraryFood Safety Research Projects Database Search | National Agricultural Library
or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. ...
https://www.nal.usda.gov/research-tools/food-safety-research-projects/search?f%5B0%5D=category%3A9&f%5B1%5D=commodity%3A86&node=2215&sort=search_api_relevance&order=desc
LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4
... Author: Haebig, Karina; Gellhaar, ... LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4. DSpace Repository. Login ...
https://bibliographie.uni-tuebingen.de/xmlui/handle/10900/55839
Elimination of the major allergen tropomyosin from shrimp muscle by boiling treatment<...
Tropomyosin (TM) is the major allergen found in invertebrates, including shrimp. To reduce the allergenicity of shrimp muscle, ... N2 - Tropomyosin (TM) is the major allergen found in invertebrates, including shrimp. To reduce the allergenicity of shrimp ... AB - Tropomyosin (TM) is the major allergen found in invertebrates, including shrimp. To reduce the allergenicity of shrimp ... abstract = "Tropomyosin (TM) is the major allergen found in invertebrates, including shrimp. To reduce the allergenicity of ...
https://tohoku.pure.elsevier.com/en/publications/elimination-of-the-major-allergen-tropomyosin-from-shrimp-muscle-
ATRIP ATR interacting protein [Homo sapiens (human)] - Gene - NCBIATRIP ATR interacting protein [Homo sapiens (human)] - Gene - NCBI
Tropomyosin_1; Tropomyosin like. RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details.... The following ...
https://www.ncbi.nlm.nih.gov/gene/84126
EMDB < EMD...EMDB < EMD...
Helical reconstruction of the human cardiac actin-tropomyosin-myosin complex in the rigor form ... Sample: Human cardiac actin-tropomyosin-beta-myosin II complex in the rigor form.. Fitted models: 8efi () Deposition Authors: ... Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation Doran MH , ... Helical reconstruction of the human cardiac actin-tropomyosin-myosin complex in the rigor form. ...
https://www.ebi.ac.uk/emdb/EMD-28083
A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy NEM1. - SCNi
A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy NEM1. ... A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy NEM1. ...
https://www.scni.ox.ac.uk/publications/827121
Recombinant Mouse EGF-containing fibulin-like extracellular matrix protein 1 (Efemp1) | CSB-MP007450MO | CusabioRecombinant Mouse EGF-containing fibulin-like extracellular matrix protein 1 (Efemp1) | CSB-MP007450MO | Cusabio
Tropomyosin Antibody, Biotin conjugated , CSB-PA889027HD01DRR , CusabioTropomyosin Antibody, Biotin conjugated is Available at ...
https://joplink.net/recombinant-mouse-egf-containing-fibulin-like-extracellular-matrix-protein-1-efemp1-csb-mp007450mo/
Lauzonlab » Molecular Mechanical Differences between Isoforms of Contractile Actin in the Presence of Isoforms of Smooth Muscle...Lauzonlab » Molecular Mechanical Differences between Isoforms of Contractile Actin in the Presence of Isoforms of Smooth Muscle...
Molecular Mechanical Differences between Isoforms of Contractile Actin in the Presence of Isoforms of Smooth Muscle Tropomyosin ... Molecular Mechanical Differences between Isoforms of Contractile Actin in the Presence of Isoforms of Smooth Muscle Tropomyosin ...
http://lauzonlabmcgill.com/molecular-mechanical-differences-between-isoforms-of-contractile-actin-in-the-presence-of-isoforms-of-smooth-muscle-tropomyosin/
Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics. - Texas A&M University (TAMU) Scholar
... ... Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics. Academic Article * ... The ends of striated muscle tropomyosin (TM) are integral for thin filament cooperativity, determining the cooperative unit ...
https://vivo.library.tamu.edu/vivo/display/n74771SE
Proteomes | Free Full-Text | Differential Proteome Analysis of Extracellular Vesicles from Breast Cancer Cell Lines by...Proteomes | Free Full-Text | Differential Proteome Analysis of Extracellular Vesicles from Breast Cancer Cell Lines by...
Tropomyosin a-1 chain. H0YKP3. 3. 10. assembly. Agrin. O00468. 5. 9. assembly. ...
https://www.mdpi.com/2227-7382/5/4/25
TroponinTPM3Actin filamentsSkeletalThin filamentKinaseGeneProteinsProteinCardiacFilamentsHypertrophic cardiomyopathy0.05MollusksDescriptorELISAMajorAlphaCriticalMuscle cellsRoleStateSitesRegionBeta-tropomyosinTPM1MutationTroponin and tropomyosinReceptor kinasesBindsAllergenIsoformsTrkBTrkAMutationsInhibitorAntibodiesTumorsMuscle contractionNeurotrophin receptorsIsoformSkeletalShellfishCongenital myopathyOverlap regionRegulationCalmodulinSequenceDiseasesNeurotrophicFilamentAlpha helicalAntigenActomyosinCytoplasmicBound
Troponin11
  • The protein intricate troponin binds to tropomyosin helping to ant: disarray it on the actin molecule. (sahmy.com)
  • Calcium is required by two proteins troponin and tropomyosin that methodize muscle contraction by blocking the restrictive of myosin to filamentous actin. (sahmy.com)
  • Vertebrate striated muscle contraction is controlled (regulated) by the separation of the proteins troponin and tropomyosin on the actin filaments. (sahmy.com)
  • The molecular rule of striated muscle contraction couples the restrictive and dissociation of Ca2+ on troponin to the motion of tropomyosin on actin filaments. (sahmy.com)
  • What does tropomyosin and troponin do? (sahmy.com)
  • Tropomyosin and troponin hinder myosin engage restrictive to actin briefly the muscle is in a dull state. (sahmy.com)
  • Troponin binds to tropomyosin and helps to ant: disarray it on the actin atom it also binds calcium ions. (sahmy.com)
  • By restrictive to troponin Ca2+ causes it to change ant: disarray and ant: slave tropomyosin exposing the restrictive sites on actin. (sahmy.com)
  • In striated muscles, tropomyosin interacts with the troponin complex to regulate actin-myosin interaction. (biomedcentral.com)
  • Binding of troponin-T fragments to several types of tropomyosin. (wikidata.org)
  • Thus FHC mutations in alpha-tropomyosin produce detectable changes in the Ca2+-regulation of thin filaments, presumably via altered interaction with troponin. (ox.ac.uk)
TPM34
  • α-tropomyosin gene (TPM3) mutation in an infant with nemaline myopathy" by Sulaiman Almobarak, Jonathan Hu et al. (uwo.ca)
  • Currently, no definite treatment exists for CM. A de novo mutation in Tropomyosin 3- TPM3 (E151G) was identified from a boy diagnosed with CM, previously TPM3 (E151A) was reported to cause CM. However, the role of TPM3 (E151G) in CM is unknown. (biomedcentral.com)
  • The TPM2 and TPM3 genes provide instructions for making proteins that are members of the tropomyosin protein family. (medlineplus.gov)
  • A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy NEM1. (ox.ac.uk)
Actin filaments4
  • Actin, alpha-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells. (rupress.org)
  • Immunofluorescence studies with antibodies specific for the skeletal muscle structural proteins actin, alpha-actinin, and tropomyosin indicate that this network is composed of foci containing actin and alpha-actinin, connected by tropomyosin-associated actin filaments. (rupress.org)
  • Actin filaments, having both tropomyosin and alpha-actinin associated with them, are also seen to extend from the vertices of this network to the edges of the cell. (rupress.org)
  • These results demonstrate a specific interaction of alpha-actinin and tropomyosin with actin filaments during the assembly and organization of the actin filament bundles of tissue culture cells. (rupress.org)
Skeletal7
  • What is the main function of tropomyosin in skeletal muscles? (sahmy.com)
  • Tropomyosin (Tpm) is a superiority ingredient of the slim filament in skeletal muscles and plays an significant role in controlling muscle contraction and relaxation. (sahmy.com)
  • 25/01/2022 · Tropomyosin is one of many proteins involved in allowing the skeletal muscles to expand and contract. (mycoolclips.com)
  • Mutations have been identified in α-tropomyosin (Tm), a key regulatory protein in striated muscle cells, that are associated with a human cardiac myopathy, hypertrophic cardiomyopathy (FHC) and a human skeletal myopathy, nemaline myopathy (NM). (umn.edu)
  • Michele, DE & Metzger, JM 2000, ' Physiological consequences of tropomyosin mutations associated with cardiac and skeletal myopathies ', Journal of Molecular Medicine , vol. 78, no. 10, pp. 543-553. (umn.edu)
  • Wild type AS-alpha-Tm and AS-alpha-Tm(Asp175Asn) binding to actin was indistinguishable from rabbit skeletal muscle ab-tropomyosin whilst the affinity of AS-alpha-Tm(Glu180Gly) was about threefold weaker. (ox.ac.uk)
  • In vitro motility assays were performed with AS-alpha-tropomyosin incorporated into skeletal muscle actin-rhodamine phalloidin filaments moving over skeletal muscle heavy meromyosin. (ox.ac.uk)
Thin filament3
  • Tropomyosin (TM) is an integral component of the thin filament in muscle fibers and is involved in regulating actin-myosin interactions. (elsevier.com)
  • The ends of striated muscle tropomyosin (TM) are integral for thin filament cooperativity, determining the cooperative unit size and regulating the affinity of TM for actin. (tamu.edu)
  • Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility. (ox.ac.uk)
Kinase1
Gene2
  • Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene. (bmj.com)
  • Cap disease due to mutation of the beta-tropomyosin gene (TPM2). (medlineplus.gov)
Proteins1
  • Regulatory Proteins See also what is the facing of solar Tropomyosin blocks myosin restrictive sites on actin molecules preventing cross-bridge shape and preventing contraction in a muscle without nervous input. (sahmy.com)
Protein2
  • Hodges RS, Mills J, McReynolds S, Kirwan JP, Tripet B, Osguthorpe D. Identification of a unique "stability control region" that controls protein stability of tropomyosin: A two-stranded alpha-helical coiled-coil. (ucdenver.edu)
  • The helical F-actin filament found in muscles also contains a tropomyosin molecule, which is a 40 nanometre long protein that is wrapped around the F-actin helix. (mycoolclips.com)
Cardiac1
  • Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics. (tamu.edu)
Filaments1
  • On restrictive Ca2+ Tn transmits instruction via structural changes throughout the actin-tropomyosin filaments activating myosin ATPase agility and muscle contraction. (sahmy.com)
Hypertrophic cardiomyopathy1
  • The functional properties of wild type alpha-tropomyosin expressed in E. coli with an alanine-serine N-terminal leader (AS-alpha-Tm) were compared with those of AS-alpha-Tm with either of two missense mutations (Asp175Asn and Glu180Gly) shown to cause familial hypertrophic cardiomyopathy (FHC). (ox.ac.uk)
0.051
  • 0.05 compared with AS-alpha-tropomyosin). (ox.ac.uk)
Mollusks2
  • The AgraQuant ® Mollusk is a sandwich enzyme-linked immunosorbent assay (ELISA) designed for the quantitative analysis of tropomyosin, the major allergen in mollusks, in food samples. (romerlabs.com)
  • Tropomyosin is considered the major seafood antigen and can be found in many types of mollusks. (cdc.gov)
Descriptor1
  • Tropomyosin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
ELISA1
  • This Tropomyosin Alpha antibody is for WB, ELISA. (lifchem.com)
Major2
  • This graph shows the total number of publications written about "Tropomyosin" by people in this website by year, and whether "Tropomyosin" was a major or minor topic of these publications. (ucdenver.edu)
  • Tropomyosin (TM) is the major allergen found in invertebrates, including shrimp. (elsevier.com)
Alpha1
  • Description: A polyclonal antibody for detection of Tropomyosin Alpha from Human, Mouse, Rat. (lifchem.com)
Critical1
  • Critical interactions in the stability control region of tropomyosin. (ucdenver.edu)
Muscle cells1
  • What is the function of tropomyosin in muscle cells Group of answer choices? (sahmy.com)
Role1
  • What is tropomyosin role in muscle contraction? (sahmy.com)
State1
  • Striated muscle in the relaxed state has tropomyosin covering myosin-binding sites on actin. (mycoolclips.com)
Sites2
  • Tropomyosin blocks myosin restrictive sites on actin molecules preventing cross-bridge shape which prevents contraction in a muscle without nervous input. (sahmy.com)
  • Tropomyosin serves as a contraction inhibitor by blocking the myosin restrictive sites on the actin molecules. (sahmy.com)
Region1
  • Transmission of stability information through the N-domain of tropomyosin is interrupted by a stabilizing mutation (A109L) in the hydrophobic core of the stability control region (residues 97-118). (ucdenver.edu)
Beta-tropomyosin5
  • Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function. (ox.ac.uk)
  • Cap disease due to mutation of the beta-tropomyosin gene (TPM2). (medlineplus.gov)
  • Donner K, Ollikainen M, Ridanpää M, Christen HJ, Goebel HH, de Visser M, Pelin K, Wallgren-Pettersson C. Mutations in the beta-tropomyosin (TPM2) gene--a rare cause of nemaline myopathy. (medlineplus.gov)
  • Lehtokari VL, Ceuterick-de Groote C, de Jonghe P, Marttila M, Laing NG, Pelin K, Wallgren-Pettersson C. Cap disease caused by heterozygous deletion of the beta-tropomyosin gene TPM2. (medlineplus.gov)
  • Absence of beta-tropomyosin is a new cause of Escobar syndrome associated with nemaline myopathy. (medlineplus.gov)
TPM14
  • Tropomyosin 1 (TPM1) is an actin binding protein required for cytoskeletal functions in non-muscle cells and for contraction in muscle cells. (biorxiv.org)
  • 2015. Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies. . (ncbs.res.in)
  • Altered miR-21 has been found to be associated with the proliferation, invasion and apoptosis of malignant cells by targeting and downregulating a number of tumor suppressors, including PTEN ( 6 , 7 ), programmed cell death 4 (PDCD4) ( 8 - 11 ), bcl-2 and tropomyosin l (TPM1) ( 12 - 13 ), bone morphogenetic protein receptor II (BMPRII) ( 14 ) and sprouty 2 (SPRY2) ( 15 ). (spandidos-publications.com)
  • We have recently identified that tropomyosin 1 (TPM1), an actin binding protein, regulates inflammation and neuronal remodelling in the aging retina. (edu.hk)
Mutation4
  • We review the clinical and morphological expression of the previously reported mutations illustrating the heterogeneity of β-tropomyosin-associated diseases and describe an additional case with a novel mutation. (nih.gov)
  • In addition, Escobar syndrome with nemaline myopathy is a manifestation of homozygous truncating β-tropomyosin mutation. (nih.gov)
  • Transgenic expression of α-tropomyosin containing a Glu180Gly mutation (TM180) in mice of a mixed C57BL/6:FVB/N background induces a cardiomyopathy characterized by a small left ventricle, interstitial fibrosis, and diminished systolic and diastolic function. (elsevier.com)
  • By examining the effects of an A295S α-cardiac actin hypertrophic cardiomyopathy-causing mutation, over a range of increasingly complex in silico, in vitro, and in vivo Drosophila muscle models, we propose that subtle A-triad-tropomyosin perturbation can destabilize thin filament regulation, which leads to hypercontractility and triggers disease. (elsevier.com)
Troponin and tropomyosin3
  • Observed changes in X-ray reflections arising from myosin heads, actin filaments, troponin, and tropomyosin were consistent with the hypothesis that troponin bridges are the key agent of mechanical signal transduction. (duke.edu)
  • Cooperative mechanism * 2 simulates end-to-end interactions between adjacent troponin * and tropomyosin. (nih.gov)
  • To elucidate this regulatory mechanism, the three-dimensional organization of troponin and tropomyosin on the thin filament must be determined. (infona.pl)
Receptor kinases3
  • Larotrectinib Sulfate is a potent and selective oral ATP-competitive inhibitor of tropomyosin receptor kinases (TRK). (chemicalbook.com)
  • Axonal survival and growth requires signalling from tropomyosin receptor kinases (Trks). (abberior.rocks)
  • Larotrectinib is an inhibitor of the tropomyosin receptor kinases (TRK), TRKA, TRKB, and TRKC. (smtbd.net)
Binds4
  • Three types of troponins exist-troponin I, troponin T, and troponin C. Each subunit has a unique function: Troponin T binds the troponin components to tropomyosin, troponin I inhibits the interaction of myosin with actin, and troponin C contains the binding sites for Ca 2+ that helps initiate contraction. (medscape.com)
  • It binds actin, myosin, tropomyosin and calmodulin and is believed to play in smooth muscle a regulatory role similar to that of troponin in striated muscle. (novapublishers.com)
  • 4. When troponin binds Ca2+, tropomyosin changes its binding to actin in such a way that it exposes the actin site for myosin cross-bridging. (wgpeters.com)
  • It binds with trophin and stimulates it to move tropomyosin, which then exposes the binding site for the crossbridge. (blablawriting.net)
Allergen4
  • 45%. Während einer Infektion fungiert Tropomyosin als funktionelles Allergen und führt zur Produktion von hohen Mengen spezifischen IgEs. (hu-berlin.de)
  • During infection tropomyosin is an allergen and leads to the production of high levels of specific IgE. (hu-berlin.de)
  • The main shellfish allergen is tropomyosin. (organicauthority.com)
  • The AgraQuant ® Mollusk is a sandwich enzyme-linked immunosorbent assay (ELISA) designed for the quantitative analysis of tropomyosin, the major allergen in mollusks, in food samples. (romerlabs.com)
Isoforms4
  • In these studies we have compared the relative amounts and isoforms of tropomyosin in capillary and postcapillary venule pericytes, endothelial cells, and vascular smooth muscle cells in four rat microvascular beds: heart, diaphragm, pancreas, and the intestinal mucosa. (rupress.org)
  • Moreover, they are regulated by post-translational modifications, specific interactions with actin and tropomyosin isoforms, and light chain activation mechanisms. (mhh.de)
  • To better define and understand the regulation of nonsarcomeric myosins in mammalian cells, we implement an approach that examines myosin enzymology, post-translational modifications, cellular interactions with specific actin and tropomyosin isoforms and how these affect chemo-mechanical properties. (mhh.de)
  • Although detailed knowledge of the generic myosin ATPase cycle and motor domain structure has been accumulated, much less is known about interactions between specific nonsarcomeric myosin and actin isoforms, their regulation by tropomyosin isoforms, the respective subcellular localization of these complexes in specific tissues and cell lines and the effect of post-translational modifications on their enzymology. (mhh.de)
TrkB1
  • In this study, we investigated the cellular effects of nociceptive stimulation in contused adult rats focusing on BDNF, its receptor, tropomyosin-receptor kinase (TrkB), and the subsequent downstream signaling system. (tamu.edu)
TrkA1
  • TrkA (tropomyosin receptor kinase A) encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. (thermofisher.com)
Mutations5
  • The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ. (nih.gov)
  • Mutations in TPM2, encoding β-tropomyosin, have recently been found to cause a range of muscle disorders. (nih.gov)
  • The dominant β-tropomyosin mutations manifest either as congenital myopathy or distal arthrogryposis. (nih.gov)
  • Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy. (harvard.edu)
  • We have investigated the effect of the E41K, R91G, and E139del β-tropomyosin (TM) mutations that cause congenital myopathy on the position of TM and orientation of actin monomers and myosin heads at different mimicked stages of the ATPase cycle in troponin-free ghost muscle fibers by polarized fluorimetry. (ox.ac.uk)
Inhibitor2
Antibodies4
  • A part of the study was also aimed at the development of anti-tropomyosin monoclonal antibodies (mAb). (hu-berlin.de)
  • Antibodies to tropomyosin cross-react with antigens to dust mites and cockroaches. (cdc.gov)
  • Antibodies trigger the release of chemicals such as histamines to attack the tropomyosin. (onteenstoday.com)
  • Heart reactive antibodies: Tropomyosin is elevated in persons with acute rheumatic fever. (medscape.com)
Tumors1
  • Tropomyosin-Related Kinase Fusions in Gastrointestinal Stromal Tumors. (cdc.gov)
Muscle contraction1
  • Muscle contraction is regulated by troponin-tropomyosin, which blocks and unblocks myosin binding sites on actin. (infona.pl)
Neurotrophin receptors1
  • Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75. (vanderbilt.edu)
Isoform2
  • and (c) pericytes, unlike endothelia and other nonmuscle cells, contain detectable levels of tropomyosin immunologically related to the smooth muscle isoform. (rupress.org)
  • Complementary DNAs (cDNA)encoding an S 2 isoform of myosin heavy chain (MHC) and an S 2 isoform of tropomyosin (Tm) were isolated from the superficial abdominal flexor muscles of adult lobsters. (biologists.com)
Skeletal1
  • β-tropomyosin is found primarily in skeletal muscles, which are the muscles used for movement. (medlineplus.gov)
Shellfish1
  • Shellfish Tropomyosin IgE Cross-Reactivity Differs Among Edible Insect Species. (comparedatabase.org)
Congenital myopathy1
  • Aberrant movement of β-tropomyosin associated with congenital myopathy causes defective response of myosin heads and actin during the ATPase cycle. (ox.ac.uk)
Overlap region1
  • 2017. Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region. . (ncbs.res.in)
Regulation1
  • 16. Regulation of nonmuscle myosin II by tropomyosin. (nih.gov)
Calmodulin1
  • It is capable of binding to actin, calmodulin, troponin C and tropomyosin. (fishersci.com)
Sequence1
  • The time-resolved sequence of molecular changes suggests a mechanism for stretch activation, in which troponin bridges mechanically tug tropomyosin aside to relieve tropomyosin's steric blocking of myosin-actin binding. (duke.edu)
Diseases1
  • Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases. (nih.gov)
Neurotrophic3
  • Intermittent noxious stimulation following spinal cord contusion injury impairs locomotor recovery and reduces spinal brain-derived neurotrophic factor-tropomyosin-receptor kinase signaling in adult rats. (tamu.edu)
  • and 3) upregulated p75 neurotrophic receptor, truncated tropomyosin kinase B (inactive receptor), and cleaved caspase-3. (unl.pt)
  • Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer. (fapesp.br)
Filament2
  • A consequence of the geometry is that the orientation of postulated periodic actin binding sites on the coiled-coil surface is retained from one molecule to the next along the actin filament when the overlap complex is modeled into the X-ray structure of tropomyosin determined at 7 Angstroms. (rcsb.org)
  • Nuclear relaxation NMR data reveal flexibility of the junction, which may function to optimize binding along the helical actin filament and to allow mobility of tropomyosin on the filament surface as it switches between regulatory states. (rcsb.org)
Alpha helical2
  • Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. (nih.gov)
  • Tropomyosin (Tm) is a dimer made of two alpha helical chains associated into a parallel coiled-coil. (kent.ac.uk)
Antigen1
  • This study revealed that tropomyosin is a promising antigen for vaccines against filarial nematodes, however, effective only in a Th1 biased environment. (hu-berlin.de)
Actomyosin1
  • Findings suggest that electrostatic contacts, particularly those between K326, K328, and R147 on actin and tropomyosin, establish an energetically favorable F-actin-tropomyosin configuration, with tropomyosin positioned in a location that impedes actomyosin associations and promotes relaxation. (elsevier.com)
Cytoplasmic3
  • The retinoids increased the levels of α-tropomyosin and troponin-T in the cytoplasmic and cytoskeletal fractions of cells at all three stages of development. (uniss.it)
  • The greatest increases in α-tropomyosin occurred in the cytoplasmic fraction in HH22 cells cultured for 24 h with all-trans RA or 13-cis RA, whereas the greatest increases in troponin-T were found in the cytoplasmic fraction of HH32 cells exposed to retinoids for 24 h. (uniss.it)
  • In cultures treated for 48 h with retinoids, the levels of α-tropomyosin and troponin-T showed significant increases in the cytoplasmic compartment of cells treated in HH32-with respect to the control values. (uniss.it)
Bound1
  • T represents tropomyosin, TCa is Ca2+ bound * tropomyosin, N0, N1, P0 and P1 are the non-permissive and permissive * tropomyosin states. (nih.gov)
Cap myopathy: MedlinePlus Genetics
Cap myopathy: MedlinePlus Genetics (medlineplus.gov)
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