A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
A condition of elevated levels of TRIGLYCERIDES in the blood.
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
A class of lipoproteins of very light (0.93-1.006 g/ml) large size (30-80 nm) particles with a core composed mainly of TRIGLYCERIDES and a surface monolayer of PHOSPHOLIPIDS and CHOLESTEROL into which are imbedded the apolipoproteins B, E, and C. VLDL facilitates the transport of endogenously made triglycerides to extrahepatic tissues. As triglycerides and Apo C are removed, VLDL is converted to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LOW-DENSITY LIPOPROTEINS from which cholesterol is delivered to the extrahepatic tissues.
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
Conditions with excess LIPIDS in the blood.
Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form.
Glucose in blood.
Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.
(Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester.
A class of lipoproteins that carry dietary CHOLESTEROL and TRIGLYCERIDES from the SMALL INTESTINE to the tissues. Their density (0.93-1.006 g/ml) is the same as that of VERY-LOW-DENSITY LIPOPROTEINS.
The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.
Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.
A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS and CHYLOMICRON REMNANTS. Apo C-III, synthesized in the liver, is an inhibitor of LIPOPROTEIN LIPASE. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (RECEPTORS, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of SIALIC ACID (Apo C-III-0, Apo C-III-1, and Apo C-III-2).
Abstaining from all food.
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.
A group of apolipoproteins that can readily exchange among the various classes of lipoproteins (HDL; VLDL; CHYLOMICRONS). After lipolysis of TRIGLYCERIDES on VLDL and chylomicrons, Apo-C proteins are normally transferred to HDL. The subtypes can modulate remnant binding to receptors, LECITHIN CHOLESTEROL ACYLTRANSFERASE, or LIPOPROTEIN LIPASE.
A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.
The time frame after a meal or FOOD INTAKE.
Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma concentration in TANGIER DISEASE.
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A 513-kDa protein synthesized in the LIVER. It serves as the major structural protein of low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). It is the ligand for the LDL receptor (RECEPTORS, LDL) that promotes cellular binding and internalization of LDL particles.
Cholesterol which is contained in or bound to very low density lipoproteins (VLDL). High circulating levels of VLDL cholesterol are found in HYPERLIPOPROTEINEMIA TYPE IIB. The cholesterol on the VLDL is eventually delivered by LOW-DENSITY LIPOPROTEINS to the tissues after the catabolism of VLDL to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LDL.
A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Emulsions of fats or lipids used primarily in parenteral feeding.
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
A hypertriglyceridemia disorder, often with autosomal dominant inheritance. It is characterized by the persistent elevations of plasma TRIGLYCERIDES, endogenously synthesized and contained predominantly in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). In contrast, the plasma CHOLESTEROL and PHOSPHOLIPIDS usually remain within normal limits.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.
An enzyme that catalyses the last step of the TRIACYLGLYCEROL synthesis reaction in which diacylglycerol is covalently joined to LONG-CHAIN ACYL COA to form triglyceride. It was formerly categorized as EC
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
An antilipemic agent which reduces both CHOLESTEROL and TRIGLYCERIDES in the blood.
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
A 241-kDa protein synthesized only in the INTESTINES. It serves as a structural protein of CHYLOMICRONS. Its exclusive association with chylomicron particles provides an indicator of intestinally derived lipoproteins in circulation. Apo B-48 is a shortened form of apo B-100 and lacks the LDL-receptor region.
An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)
A triglyceride that is used as an antifungal agent.
A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.
The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277)
Regular course of eating and drinking adopted by a person or animal.
Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)
GLYCEROL esterified with FATTY ACIDS.
An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.
Oils high in unsaturated fats extracted from the bodies of fish or fish parts, especially the LIVER. Those from the liver are usually high in VITAMIN A. The oils are used as DIETARY SUPPLEMENTS. They are also used in soaps and detergents and as protective coatings.
Transport proteins that carry specific substances in the blood or across cell membranes.
Substances used to lower plasma CHOLESTEROL levels.
A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.
Conditions with abnormally elevated levels of LIPOPROTEINS in the blood. They may be inherited, acquired, primary, or secondary. Hyperlipoproteinemias are classified according to the pattern of lipoproteins on electrophoresis or ultracentrifugation.
Oils derived from plants or plant products.
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
De novo fat synthesis in the body. This includes the synthetic processes of FATTY ACIDS and subsequent TRIGLYCERIDES in the LIVER and the ADIPOSE TISSUE. Lipogenesis is regulated by numerous factors, including nutritional, hormonal, and genetic elements.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
An antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW DENSITY LIPOPROTEINS and increases HIGH DENSITY LIPOPROTEINS.
An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. This enzyme has alpha, beta, gamma, delta and epsilon subunits.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.
A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
The glyceryl esters of a fatty acid, or of a mixture of fatty acids. They are generally odorless, colorless, and tasteless if pure, but they may be flavored according to origin. Fats are insoluble in water, soluble in most organic solvents. They occur in animal and vegetable tissue and are generally obtained by boiling or by extraction under pressure. They are important in the diet (DIETARY FATS) as a source of energy. (Grant & Hackh's Chemical Dictionary, 5th ed)
A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.
LIPOLYSIS of stored LIPIDS in the ADIPOSE TISSUE to release FREE FATTY ACIDS. Mobilization of stored lipids is under the regulation of lipolytic signals (CATECHOLAMINES) or anti-lipolytic signals (INSULIN) via their actions on the hormone-sensitive LIPASE. This concept does not include lipid transport.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Elements of limited time intervals, contributing to particular results or situations.
Cholesterol present in food, especially in animal products.
The interstitial fluid that is in the LYMPHATIC SYSTEM.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY.
The consumption of edible substances.
The process of converting an acid into an alkyl or aryl derivative. Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. Esterification can also be accomplished by enzymatic processes.
A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.
Substances which lower blood glucose levels.
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS. It contains a cofactor for LIPOPROTEIN LIPASE and activates several triacylglycerol lipases. The association of Apo C-II with plasma CHYLOMICRONS; VLDL, and HIGH-DENSITY LIPOPROTEINS is reversible and changes rapidly as a function of triglyceride metabolism. Clinically, Apo C-II deficiency is similar to lipoprotein lipase deficiency (HYPERLIPOPROTEINEMIA TYPE I) and is therefore called hyperlipoproteinemia type IB.
Relating to the size of solids.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
The measurement around the body at the level of the ABDOMEN and just above the hip bone. The measurement is usually taken immediately after exhalation.
Consumption of excessive DIETARY FATS.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
An autosomal recessive disorder of lipid metabolism. It is caused by mutation of the microsomal triglyceride transfer protein that catalyzes the transport of lipids (TRIGLYCERIDES; CHOLESTEROL ESTERS; PHOSPHOLIPIDS) and is required in the secretion of BETA-LIPOPROTEINS (low density lipoproteins or LDL). Features include defective intestinal lipid absorption, very low serum cholesterol level, and near absent LDL.
An enzyme that catalyzes the formation of oleoyl-CoA, A, and water from stearoyl-CoA, AH2, and oxygen where AH2 is an unspecified hydrogen donor.
BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.
The metabolic substances ACETONE; 3-HYDROXYBUTYRIC ACID; and acetoacetic acid (ACETOACETATES). They are produced in the liver and kidney during FATTY ACIDS oxidation and used as a source of energy by the heart, muscle and brain.
An examination of chemicals in the blood.
A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
Colipase I and II, consisting of 94-95 and 84-85 amino acid residues, respectively, have been isolated from porcine pancreas. Their role is to prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.
Oil from ZEA MAYS or corn plant.
Uptake of substances through the lining of the INTESTINES.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
The relative amounts of various components in the body, such as percentage of body fat.
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
A mixture of very-low-density lipoproteins (VLDL), particularly the triglyceride-poor VLDL, with slow diffuse electrophoretic mobilities in the beta and alpha2 regions which are similar to that of beta-lipoproteins (LDL) or alpha-lipoproteins (HDL). They can be intermediate (remnant) lipoproteins in the de-lipidation process, or remnants of mutant CHYLOMICRONS and VERY-LOW-DENSITY LIPOPROTEINS which cannot be metabolized completely as seen in FAMILIAL DYSBETALIPOPROTEINEMIA.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
An autosomal recessively inherited disorder characterized by the accumulation of intermediate-density lipoprotein (IDL or broad-beta-lipoprotein). IDL has a CHOLESTEROL to TRIGLYCERIDES ratio greater than that of VERY-LOW-DENSITY LIPOPROTEINS. This disorder is due to mutation of APOLIPOPROTEINS E, a receptor-binding component of VLDL and CHYLOMICRONS, resulting in their reduced clearance and high plasma levels of both cholesterol and triglycerides.
The chemical reactions involved in the production and utilization of various forms of energy in cells.
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The measurement of an organ in volume, mass, or heaviness.
Fatty acids which are unsaturated in only one position.
A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
Eighteen-carbon essential fatty acids that contain two double bonds.
Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
A group of familial disorders characterized by elevated circulating cholesterol contained in either LOW-DENSITY LIPOPROTEINS alone or also in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins).
The amount of fat or lipid deposit at a site or an organ in the body, an indicator of body fat status.
A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A continuous cell line that is a substrain of SWISS 3T3 CELLS developed though clonal isolation. The mouse fibroblast cells undergo an adipose-like conversion as they move to a confluent and contact-inhibited state.
Salts and esters of the 16-carbon saturated monocarboxylic acid--palmitic acid.
The rate dynamics in chemical or physical systems.
An inherited condition due to a deficiency of either LIPOPROTEIN LIPASE or APOLIPOPROTEIN C-II (a lipase-activating protein). The lack of lipase activities results in inability to remove CHYLOMICRONS and TRIGLYCERIDES from the blood which has a creamy top layer after standing.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
A diet that contains limited amounts of fat with less than 30% of calories from all fats and less than 10% from saturated fat. Such a diet is used in control of HYPERLIPIDEMIAS. (From Bondy et al, Metabolic Control and Disease, 8th ed, pp468-70; Dorland, 27th ed)
7-carbon saturated monocarboxylic acids.
The second most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. It has a high lipid affinity and is known to displace APOLIPOPROTEIN A-I from HDL particles and generates a stable HDL complex. ApoA-II can modulate the activation of LECITHIN CHOLESTEROL ACYLTRANSFERASE in the presence of APOLIPOPROTEIN A-I, thus affecting HDL metabolism.
Pathological conditions resulting from abnormal anabolism or catabolism of lipids in the body.
An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
Fats containing one or more double bonds, as from oleic acid, an unsaturated fatty acid.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Total number of calories taken in daily whether ingested or by parenteral routes.
Centrifugation with a centrifuge that develops centrifugal fields of more than 100,000 times gravity. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
A plant genus of the family ARECACEAE. It is a tropical palm tree that yields a large, edible hard-shelled fruit from which oil and fiber are also obtained.
Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
A collection of heterogenous conditions resulting from defective LIPID METABOLISM and characterized by ADIPOSE TISSUE atrophy. Often there is redistribution of body fat resulting in peripheral fat wasting and central adiposity. They include generalized, localized, congenital, and acquired lipodystrophy.
Errors in the metabolism of LIPIDS resulting from inborn genetic MUTATIONS that are heritable.
Unsaturated fats or oils used in foods or as a food.
Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Fatty tissue inside the ABDOMINAL CAVITY, including visceral fat and retroperitoneal fat. It is the most metabolically active fat in the body and easily accessible for LIPOLYSIS. Increased visceral fat is associated with metabolic complications of OBESITY.
Method of analyzing chemicals using automation.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The technique that deals with the measurement of the size, weight, and proportions of the human or other primate body.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Mutant mice exhibiting a marked obesity coupled with overeating, hyperglycemia, hyperinsulinemia, marked insulin resistance, and infertility when in a homozygous state. They may be inbred or hybrid.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The white liquid secreted by the mammary glands. It contains proteins, sugar, lipids, vitamins, and minerals.
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).
Agents that increase energy expenditure and weight loss by neural and chemical regulation. Beta-adrenergic agents and serotoninergic drugs have been experimentally used in patients with non-insulin dependent diabetes mellitus (NIDDM) to treat obesity.
Decrease in existing BODY WEIGHT.
A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma CHYLOMICRONS and TRIGLYCERIDES contained in VERY-LOW-DENSITY LIPOPROTEINS. Type V hyperlipoproteinemia is often associated with DIABETES MELLITUS and is not caused by reduced LIPOPROTEIN LIPASE activity as in HYPERLIPOPROTEINEMIA TYPE I .
Oil from soybean or soybean plant.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.
The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC
Increase in BODY WEIGHT over existing weight.
A 6.6-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS; INTERMEDIATE-DENSITY LIPOPROTEINS; and HIGH-DENSITY LIPOPROTEINS. Apo C-I displaces APO E from lipoproteins, modulate their binding to receptors (RECEPTORS, LDL), and thereby decrease their clearance from plasma. Elevated Apo C-I levels are associated with HYPERLIPOPROTEINEMIA and ATHEROSCLEROSIS.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
An oily liquid extracted from the seeds of the safflower, Carthamus tinctorius. It is used as a dietary supplement in the management of HYPERCHOLESTEROLEMIA. It is used also in cooking, as a salad oil, and as a vehicle for medicines, paints, varnishes, etc. (Dorland, 28th ed & Random House Unabridged Dictionary, 2d ed)
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC
A condition of having excess fat in the abdomen. Abdominal obesity is typically defined as waist circumferences of 40 inches or more in men and 35 inches or more in women. Abdominal obesity raises the risk of developing disorders, such as diabetes, hypertension and METABOLIC SYNDROME X.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.

Quantitative aspects in the assessment of liver injury. (1/12738)

Liver function data are usually difficult to use in their original form when one wishes to compare the hepatotoxic properties of several chemical substances. However, procedures are available for the conversion of liver function data into quantal responses. These permit the elaboration of dose-response lines for the substances in question, the calculation of median effective doses and the statistical analysis of differences in liver-damaging potency. These same procedures can be utilized for estimating the relative hazard involved if one compares the liver-damaging potency to the median effective dose for some other pharmacologie parameter. Alterations in hepatic triglycerides, lipid peroxidation, and the activities of various hepatic enzymes can also be quantitiated in a dose-related manner. This permits the selection of equitoxic doses required for certain comparative studies and the selection of doses in chemical interaction studies. The quantitative problems involved in low-frequency adverse reactions and the difficulty these present in the detection of liver injury in laboratory animals are discussed.  (+info)

Serum triglyceride: a possible risk factor for ruptured abdominal aortic aneurysm. (2/12738)

BACKGROUND: We aimed to determine the relationship between ruptured abdominal aortic aneurysm (AAA) and serum concentrations of lipids and apolipoproteins. METHODS: A cohort of 21 520 men, aged 35-64 years, was recruited from men attending the British United Provident Association (BUPA) clinic in London for a routine medical examination in 1975-1982. Smoking habits, weight, height and blood pressure were recorded at entry. Lipids and apolipoproteins were measured in stored serum samples from the 30 men who subsequently died of ruptured AAA and 150 matched controls. RESULTS: Triglyceride was strongly related to risk of ruptured AAA. In univariate analyses the risk in men on the 90th centile of the distribution relative to the risk in men on the 10th (RO10-90) was 12 (95% confidence interval [CI] : 3.8-37) for triglyceride, 5.5 (95% CI: 1.8-17) for apolipoprotein B (apoB) (the protein component of low density lipoprotein [LDL]), 0.15 (95% CI : 0.04-0.56) for apo A1 (the protein component of high density lipoprotein [HDL]), 3.7 (95% CI: 1.4-9.4) for body mass index and 3.0 (95% CI: 1.1-8.5) for systolic blood pressure. Lipoprotein (a) (Lp(a)) was not a significant risk factor (RO10-90 = 1.6, 95% CI: 0.6-3.0). In multivariate analysis triglyceride retained its strong association. CONCLUSION: Triglyceride appears to be a strong risk factor for ruptured AAA, although further studies are required to clarify this. If this and other associations are cause and effect, then changing the distribution of risk factors in the population (by many people stopping smoking and adopting a lower saturated fat diet and by lowering blood pressure) could achieve an important reduction in mortality from ruptured AAA.  (+info)

Allyl-containing sulfides in garlic increase uncoupling protein content in brown adipose tissue, and noradrenaline and adrenaline secretion in rats. (3/12738)

The effects of garlic supplementation on triglyceride metabolism were investigated by measurements of the degree of thermogenesis in interscapular brown adipose tissue (IBAT), and noradrenaline and adrenaline secretion in rats fed two types of dietary fat. In Experiment 1, rats were given isoenergetic high-fat diets containing either shortening or lard with or without garlic powder supplementation (8 g/kg of diet). After 28 d feeding, body weight, plasma triglyceride levels and the weights of perirenal adipose tissue and epididymal fat pad were significantly lower in rats fed diets supplemented with garlic powder than in those fed diets without garlic powder. The content of mitochondrial protein and uncoupling protein (UCP) in IBAT, and urinary noradrenaline and adrenaline excretion were significantly greater in rats fed a lard diet with garlic powder than in those fed the same diet without garlic. Other than adrenaline secretion, differences due to garlic were significant in rats fed shortening, also. In Experiment 2, the effects of various allyl-containing sulfides present in garlic on noradrenaline and adrenaline secretion were evaluated. Administration of diallyldisulfide, diallyltrisulfide and alliin, organosulfur compounds present in garlic, significantly increased plasma noradrenaline and adrenaline concentrations, whereas the administration of disulfides without allyl residues, diallylmonosulfide and S-allyl-L-cysteine did not increase adrenaline secretion. These results suggest that in rats, allyl-containing sulfides in garlic enhance thermogenesis by increasing UCP content in IBAT, and noradrenaline and adrenaline secretion.  (+info)

The food matrix of spinach is a limiting factor in determining the bioavailability of beta-carotene and to a lesser extent of lutein in humans. (4/12738)

Carotenoid bioavailability depends, amongst other factors, on the food matrix and on the type and extent of processing. To examine the effect of variously processed spinach products and of dietary fiber on serum carotenoid concentrations, subjects received, over a 3-wk period, a control diet (n = 10) or a control diet supplemented with carotenoids or one of four spinach products (n = 12 per group): whole leaf spinach with an almost intact food matrix, minced spinach with the matrix partially disrupted, enzymatically liquefied spinach in which the matrix was further disrupted and the liquefied spinach to which dietary fiber (10 g/kg wet weight) was added. Consumption of spinach significantly increased serum concentrations of all-trans-beta-carotene, cis-beta-carotene, (and consequently total beta-carotene), lutein, alpha-carotene and retinol and decreased the serum concentration of lycopene. Serum total beta-carotene responses (changes in serum concentrations from the start to the end of the intervention period) differed significantly between the whole leaf and liquefied spinach groups and between the minced and liquefied spinach groups. The lutein response did not differ among spinach groups. Addition of dietary fiber to the liquefied spinach had no effect on serum carotenoid responses. The relative bioavailability as compared to bioavailability of the carotenoid supplement for whole leaf, minced, liquefied and liquefied spinach plus added dietary fiber for beta-carotene was 5.1, 6.4, 9.5 and 9.3%, respectively, and for lutein 45, 52, 55 and 54%, respectively. We conclude that the bioavailability of lutein from spinach was higher than that of beta-carotene and that enzymatic disruption of the matrix (cell wall structure) enhanced the bioavailability of beta-carotene from whole leaf and minced spinach, but had no effect on lutein bioavailability.  (+info)

Improvement of factor VII clotting activity following long-term NCPAP treatment in obstructive sleep apnoea syndrome. (5/12738)

Obstructive sleep apnoea syndrome (OSAS) is a very common disorder. Patients with OSAS are at an increased risk for cardiovascular events. It has also been reported that a 25% rise in factor VII clotting activity (FVIIc) is associated with a 55% increase in ischaemic heart disease death during the first 5 years. We examined the effects of nasal continuous positive airway pressure (NCPAP) treatment on FVIIc in patients with OSAS. FVIIc was investigated prospectively in 15 patients with OSAS before (mean +/- SEM apnoea and hypopnoea index (AHI) 61.5 +/- 4.2 and after (AHI 3.0 +/- 0.9) NCPAP treatment for immediate relief, at 1 month after treatment and at over 6 months. FVIIc levels gradually decreased after NCPAP treatment. After 6 months of NCPAP treatment, FVIIc levels had decreased significantly (before 141.1 +/- 11.7% vs. after 6 months 110.7 +/- 6.2%; p < 0.01). Six of the seven patients whose FVIIc levels were over 140% before the NCPAP treatment had FVIIc levels below 130% after 6 months or 1 year of NCPAP treatment. This decrease in FVIIc after long-term NCPAP treatment could improve mortality in OSAS patients. If patients, especially obese ones, present with high FVIIc of unknown origin, it would be prudent to check for OSAS.  (+info)

Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease. (6/12738)

OBJECTIVE: To study possible associations between coronary heart disease and serological evidence of persistent infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus. DESIGN: Population based, case-control study, nested within a randomised trial. SETTING: Five general practices in Bedfordshire, UK. INDIVIDUALS: 288 patients with incident or prevalent coronary heart disease and 704 age and sex matched controls. RESULTS: High concentrations of serum IgG antibodies to H pylori were present in 54% of cases v 46% of controls, with corresponding results for C pneumoniae seropositivity (33% v 33%), and cytomegalovirus seropositivity (40% v 31%). After adjustments for age, sex, smoking, indicators of socioeconomic status, and standard risk factors, the odds ratios (95% confidence intervals) for coronary heart disease of seropositivity to these agents were: 1.28 (0.93 to 1.75) for H pylori, 0.95 (0.66 to 1.36) for C pneumoniae, and 1.40 (0.96 to 2. 05) for cytomegalovirus. CONCLUSIONS: There is no good evidence of strong associations between coronary heart disease and serological markers of persistent infection with H pylori, C pneumoniae, or cytomegalovirus. To determine the existence of moderate associations between these agents and disease, however, larger scale studies will be needed that can keep residual confounders to a minimum.  (+info)

Dietary control of triglyceride and phospholipid synthesis in rat liver slices. (7/12738)

1. The effect of dietary manipulation on the synthesis of triglycerides and phospholipids was investigated by determining the incorporation of labeled long-chain fatty acid or glycerol into these lipids in liver slices derived from normally fed, fasted, and fat-free refed rats. 2. Triglyceride synthesis was affected markedly by the dietary regime of the animal; the lowest rates were measured with fasted rats, and the highest ones with fat-free refed rats. 3. In contrast to triglyceride synthesis, phospholipid synthesis occured at virtually constant rates regardless of the dietary conditions. 4. Addition of large amounts of fatty acid to the incubation mixture resulted in a marked stimulation of triglyceride synthesis, whereas phospholipid synthesis was affected to a much smaller extent. 5. These results indicate that the synthesis of triglycerides and that of phospholipids are controlled independently, and that the availability of fatty acid in the cell contributes to the control of triglyceride synthesis.  (+info)

Extremely low values of serum leptin in children with congenital generalized lipoatrophy. (8/12738)

Congenital generalized lipoatrophy (CGL) is a syndrome with multiple clinical manifestations and complete atrophy of adipose tissue. The exact mechanism of this disease remains unknown. One hypothesis presupposes an abnormal development of adipocytes. Leptin, the adipocyte-specific product of the ob gene, acts as a regulatory factor of body weight. In children, as in adults, leptin levels are correlated with body mass index (BMI) and body fat mass. Some authors have demonstrated that adults with congenital or acquired generalized lipoatrophy have decreased leptin concentrations. In order to study serum leptin profile during childhood in this disease, we measured serum leptin concentrations in six children aged 5.5-11 years suffering from CGL, and investigated the relationship between metabolic parameters and the variations in leptin levels. Serum leptin concentrations (1.19+/-0.32 ng/ml (+/- S.D.)) were extremely low compared with those observed in normal children. No significant correlation was found with BMI, which is known to be one of the major determinants of serum leptin. Serum leptin values were significantly correlated with fasting insulin levels (r=0.83, P=0.024). In conclusion, extremely low leptin values measured in children with CGL could be regarded as one among other diagnostic parameters. However, the detectable levels observed in all of these children support the evidence that a small amount of body fat is likely to be present in these patients, despite complete subcutaneous lipoatrophy. Our data suggest that this small amount of adipose tissue could be metabolically active and, at least in part, sensitive to insulin. Further investigations are required to uncover the pathophysiological mechanisms of this syndrome, known to be commonly associated with insulin resistance.  (+info)

Trans fats increase LDL cholesterol and triglyceride levels while reducing levels of . You can lower your triglycerides by making . How should individuals decrease triglycerides (TG)? Today show nutritionist Joy Bauer shows you how to lower your triglycerides with five simple diet and lifestyle changes. The total cholesterol, triglycerides, low density lipoprotein (LDL or bad cholesterol). A heart-healthy diet is one that can help you lose weight or lower cholesterol, blood.. The meat- and dairy-free vegan diet plan is filling and has health and . GUIDELINES FOR LOW CHOLESTEROL, LOW-TRIGLYCERIDE DIETS. Marbled beef, pork, bacon, sausage, and other . A diet plan for high cholesterol and triglycerides can reduce your disease risk. A high triglycerides diet is actually pretty simple. Includes: triglycerides, triglycerides and high cholesterol, diet to lower triglycerides, exercise and triglycerides, foods to avoi foods to include in your diet, and . How to lower triglyceride level with diet and ...
TY - JOUR. T1 - Changes in plasma triglyceride metabolism during withdrawal of bile. AU - Nestel, Paul J.. AU - Grundy, Scott M. PY - 1976/11. Y1 - 1976/11. N2 - The relationship between bile acid turnover and plasma triglyceride metabolism was examined in a group of seven moderately overweight and hypertriglyceridemic men. Bile acid synthesis was stimulated by the continuous aspiration of duodenal contents so that 150% of the bile acid pool was removed in 18 hr. In comparison with the average concentration of very low density lipoprotein triglyceride (VLDL-TG) during a preceding 8-10 hr control period, bile withdrawal led to an increase in VLDL-TG of 34%, 43%, 32%, 14%, 26%, 14%, and 8% (mean +24%) in the seven men. In control studies performed on another day the mean change over a similar period of time, but without bile withdrawal, was +1% (p,0.01). The kinetics of VLDL triglyceride were studied in some of the subjects by analyzing the triglyceride specific radioactivity curves following ...
Although medium chain triglyceride (MCT) is less calorically dense than long chain triglyceride (LCT), it produces a greater thermic effect following ingestion. We hypothesized that the previously observed high rate of thermogenesis produced by MCT overfeeding was due to hepatic de novo synthesis of long chain fatty acids (LCFA) from the excess medium chain fatty acids (MCFA). To study this, we compared the effects of overfeeding MCT- and LCT-containing diets on blood lipid profiles. Ten in-patient, nonobese males were overfed (150% of estimated energy requirements) two formula diets for 6 days each, in a randomized crossover design. Diets differed only in the composition of the fat and contained either 40% of energy as MCT or LCT (soybean oil). The major differences between diets in the resulting pattern of blood lipids were: 1) a reduction in fasting serum total cholesterol concentrations with the LCT, but not the MCT diet; and 2) a threefold increase in fasting serum triglyceride ...
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Hyperinsulinemia is common in obesity, but whether it plays a role in intramyocellular triglyceride (imcTG) buildup is unknown. In this study, hyperinsulinemic-euglycemic clamp experiments were performed in overnight-fasted lean and high-fat-fed obese rats, awake, to determine the effect of insulin on imcTG synthesis (incorporation of [(14)C]glycerol, [(14)C]glucose, and [(3)H]oleate). Insulin infusion at 25 (low insulin) and 100 (high insulin) pmol/kg/min increased plasma insulin by 5- and 16-fold, respectively, whereas plasma and intramyocellular glycerol, FFAs, triglycerides, and glucose levels were maintained at their basal levels by co-infusion of exogenous glycerol, FFAs, and triglycerides at fixed rates and glucose at varying rates. In obese rats, insulin suppressed incorporation of glycerol into the imcTG-glycerol moiety dose dependently (P | 0.01-P | 0.001) in gastrocnemius and tibialis anterior, but only the high insulin suppressed it in soleus (P | 0.05). The low insulin suppressed glucose
The liver secretes triglyceride-rich VLDLs, and the triglycerides in these particles are taken up by peripheral tissues, mainly heart, skeletal muscle, and adipose tissue. Blocking hepatic VLDL secretion interferes with the delivery of liver-derived triglycerides to peripheral tissues and results in an accumulation of triglycerides in the liver. However, it is unclear how interfering with hepatic triglyceride secretion affects adiposity, muscle triglyceride stores, and insulin sensitivity. To explore these issues, we examined mice that cannot secrete VLDL [due to the absence of microsomal triglyceride transfer protein (Mttp) in the liver]. These mice exhibit markedly reduced levels of apolipoprotein B-100 in the plasma, along with reduced levels of triglycerides in the plasma. Despite the low plasma triglyceride levels, triglyceride levels in skeletal muscle were unaffected. Adiposity and adipose tissue triglyceride synthesis rates were also normal, and body weight curves were unaffected. Even ...
Medium-chain triglyceride[ Medium-chain triglyceride, MCT ] Triglycerides in which 2 or 3 of its fatty acids are medium-chain fatty acids (i.e., ranging in length from 6 to 12 carbon atoms). More, MCT[ Medium-chain triglyceride, MCT ] Triglycerides in which 2 or 3 of its fatty acids are medium-chain fatty acids (i.e., ranging in length from 6 to 12 carbon atoms). More ]. Triglycerides[ Triglyceride ] An ester comprising of a glycerol backbone and three fatty acid molecules. Triglycerides are the main constituents of natural fats and oils and act as transports for fatty acids in the blood. More in which 2 or 3 of its fatty acids[ Fatty_Acid ] A carboxylic acid with a hydrocarbon chain, usually derived from triglycerides or phospholipids. Fats, oils and esters are comprised of fatty acids. In the body, fatty acids function as the building blocks of cell membranes and signalling molecules. As fuel, they have a high-energy yield (9 kcal/gram) and are the primary means of energy storage in the More ...
When you have a health checkup, cholesterol levels are definitely on the list to ensure that your lipid profile is at target levels. High triglyceride levels put you at risk for a number of serious health issues. The lipid profile measures the fat in your blood, and there are three types to check. The LDL or bad cholesterol, the HDL or good cholesterol and triglycerides.. Ideally, total cholesterol should be less than 200 mg/dL, HDL should be 60 mg/dL or more and triglycerides should be below 150 mg/dL. A deviation from these readings leads to the build up of unhealthy cholesterol levels resulting in blocked arteries, putting you at risk for a heart attack or stroke.. Triglycerides are a crucial source of energy in the body, but high triglyceride levels are risky for heart health. This leads to a condition called metabolic syndrome characterized by low HDL cholesterol, high blood pressure, belly fat and high blood sugar, increasing increases the risk for heart disease, stroke and ...
BioAssay record AID 319416 submitted by ChEMBL: Effect on triglyceride level in 5-week old apoE-/- C57BL/6J mouse fed on western diet and 15 mg/kg/day, po drug simultaneously in 5-11 week early intervention study.
The study of this thesis concerns the dietary influence on lipid metabolism in horses. The main issue is the effect of dietary medium chain triacylglycerols (MCT) on triacylglycerol metabolism. In certain conditions high-fat diets can be beneficial for horses. Diets rich in long-chain polyunsaturated fatty acids in the form of soybean ... read more oil decrease plasma triacylglycerol concentrations and increase the activity of heparin-released lipoprotein lipase activity in horses. The metabolic adaptation to fat supplementation in the horse appears to proceed in a manner similar to that seen in response to training. The feeding of MCT versus soybean oil raised the plasma level of triacylglycerols in horses. There was no significant effect of carbohydrate source and no fat-carbohydrate interaction. However, when diets contained soybean oil, cellulose versus glucose produced significantly greater increase in plasma triacylglycerols. A major product of cellulose fermentation is acetic acid. In the ...
The Report Titled, Medium-chain Triglycerides (MCT) Market Research: Global Status & Forecast by Geography, Type & Application (2016-2026) has been recently published by Credible Markets. The Medium-chain Triglycerides (MCT) Market has been garnering remarkable momentum in recent years. Demand continues to rise due to increasing purchasing power is projected to bode well for the global market. The insightful research report on the Medium-chain Triglycerides (MCT) Market includes Porters Five Forces Analysis and SWOT Analysis to understand the factors impacting consumer and supplier behaviour. The report reviews the competitive landscape scenario seen among top Medium-chain Triglycerides (MCT) Market players, their company profile, revenue, sales, business tactics, and forecasts Medium-chain Triglycerides (MCT) Market industry situations. According to the research, the Medium-chain Triglycerides (MCT) Market is highly competing and disparate due to global and local vendors. Furthermore, the ...
The Global Medium-chain Triglycerides (MCT) market 2019 report is a meticulous study of the global Medium-chain Triglycerides (MCT) market portraying the state-of-the-art details in the market. It also predicts its growth in the next few years. The Medium-chain Triglycerides (MCT) report evaluates various aspects that determine the growth as well as the volume of the global Medium-chain Triglycerides (MCT) market. Additionally, it presents a determined business outlook of the market along with the summary of some of the leading market players. In this report, the global Medium-chain Triglycerides (MCT) is valued at USD XX million in 2017 and is expected to reach USD XX million by the end of 2025, growing at a CAGR of XX% between 2019 and 2025.. The prominent players in the global Medium-chain Triglycerides (MCT) market are IOI Oleo, Oleon, Stepan , BASF, KLK OLEO, Croda, Musim Mas , Sternchemie, BRITZ, Dr.straetmans, Acme-Hardesty, Lonza, Kao Group, ABITEC Corporation, A&A Fratelli Parodi, ...
The average triglyceride level in the United States is 134 mg/dL, or 1.5 mmol/L and is considerably higher than triglyceride levels below 100 mg/dL, or 1.1 mmol/L commonly observed in countries where heart disease rates are low.. Although medical establishments consider blood triglyceride levels of 10 - 150 mg/dL, or 0.1 - 1.7 mmol/L normal, or good, according to many experts, desirable or favorable fasting blood triglyceride levels should be 50 - 150 milligrams per deciliter (mg/dL), or 0.6 - 1.7 millimoles per liter (mmol/L) of blood.. Normal, however, does NOT necessarily mean healthy as it may include both healthy and many unhealthy people. We want healthy, not just normal serum triglyceride (and other lipid) levels.. Therefore, in order to avoid future cardiovascular health problems, the ideal or beneficial (healthy) range of triglycerides should be much tighter than the often quoted normal triglyceride range referred to by your doctor, that is below 150 mg/dL, or 1.7 ...
Very high - greater than or equal to 500 mg / dL.. What are the symptoms of high triglycerides?. The increase in triglyceride does not cause any symptoms, only the blood test is able to demonstrate its increase.. What are the causes of high triglycerides?. Triglycerides can rise for several reasons. Some people have genetic changes that predispose to this increase in these cases is common to find families with high triglycerides. Other develop elevated triglycerides errors due to food, the use of some drugs or the presence of certain diseases.. Some diseases that cause increased triglycerides are obesity, diabetesmellitus, hypothyroidism, kidney disease.. Other causes are: Diet rich in fats, excessive alcohol consumption, pregnancy.. What to do in case of high level of triglycerides?. If the doctor identifies the patient with high levels of triglycerides in the blood, it is important to inform people of the risks of heart attack and stroke. The first step is to take measures that can prevent ...
TY - JOUR. T1 - Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. AU - Watanabe, Mitsuhiro. AU - Houten, Sander M.. AU - Wang, Li. AU - Moschetta, Antonio. AU - Mangelsdorf, David J.. AU - Heyman, Richard A.. AU - Moore, David D.. AU - Auwerx, Johan. PY - 2004/1/1. Y1 - 2004/1/1. N2 - We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of molecular, cellular, and animal models. Cholic acid (CA) prevents hepatic TG accumulation, VLDL secretion, and elevated serum TG in mouse models of hypertriglyceridemia. At the molecular level, CA decreases hepatic expression of SREBP-1c and its lipogenic target genes. Through the use of mouse mutants for the short heterodimer partner (SHP) and liver X receptor (LXR) α and β, we demonstrate the critical dependence of the reduction of SREBP-1c expression by either natural or synthetic farnesoid X receptor (FXR) agonists on both SHP and LXRα and LXRβ. These results suggest that ...
Learning how to lower triglycerides is the one of the first steps you need to take when you have been diagnosed with a high triglyceride level. Choosing to ignore your triglyceride level is not an option if you are looking to have a long, healthy life.. Diet and lifestyle? Natural supplements? Prescription medicine? What treatment is right for you when it comes to lowering your triglyceride level? The choices you have in treating your high triglycerides depend on what is causing the problem. A high triglyceride level is a symptom- a sign that something is not right. For most of us, our diet and lifestyle choices are the culprit. For others, maybe not.. For others, it may be a sign of uncontrolled diabetes. Or perhaps hypothyroidism or a kidney problem. Closely working with your doctor is necessary to determine what is causing the high level of triglycerides. Taking medications to specifically lower your triglycerides if you are dealing with undiagnosed hypothyroidism or an unknown kidney issue ...
Previously we showed that chemical inhibition of iPLA2β in rat hepatoma McA-RH7777 cells attenuated hepatic VLDL assembly/secretion. To gain an insight into the role that iPLA2β plays in vivo, we generated C57BL/6 mice with targeted disruption of iPLA2β gene. The iPLA2β−/− mice developed normally to their maturity. Under chow diet conditions, female iPLA2β−/− and wild-type littermate (10-week-old) displayed no discernable difference in plasma lipid concentration or apolipoprotein levels, nor was their plasma lipoprotein profiling changed as determined by rate floatation ultracentrifugation. However, iPLA2β−/− mice liver accumulated 20% less triacylglycerol (TG) than wt controls, whereas phosphatidylcholine (PC) and phosphatidylethanolamine (PE) levels were not significantly different. Determination of VLDL-TG production rate in vivo using mice injected with poloxamer 407 (to block the lipoprotein lipase activity) revealed that accumulation of plasma TG in iPLA2β−/− mice ...
DefinitionAccording to dictionary definition Triglycerides are a type of fat found in your blood. Too much of this type of fat may raise the risk of coronary artery disease, especially in women. Causes and Risk FactorsAccording to dictionary definition Factors that can raise the triglyceride level include:1. Overweight2. Lack of physical activity3. Smoking4. Excessive alcohol use5. High carbohydrate diet6. Certain diseases and medicines7. Some genetic disorders InvestigationsAccording to dictionary definition Your doctor may recommend a blood test to measure the triglycerides along with the cholesterol. The normal triglyceride levels are below 150 and levels above 200 are high. Treatment and PreventionAccording to dictionary definition The triglyceride levels can be decreased with a combination of a few modifications such as:1. Losing weight2. Healthy diet3. Moderate exercise You may be prescribed with medicines to lower your triglycerides. NIH: National Heart, Lung, and Blood Institute. ...
Insulin action was assessed by using the hyperinsulinemic (approximately 800 pmol/L) euglycemic clamp in rats fed equal amounts of glucose or fructose (35% of calories) for 4 wk. The glucose infusion rate required to maintain euglycemia was decreased in fructose-fed animals (14.6 +/- 1.4 vs 21.8 +/- 1.1 for glucose-fed rats, p less than 0.001) with this whole-body effect contributed to equally by an impairment in hepatic insulin action and a reduction in peripheral glucose disposal in a range of tissues. There was no difference in basal glucose turnover, energy expenditure, or postprandial blood glucose and insulin responses to the diets. In the fructose-fed rats there was an increase in fasting triglyceride levels by 2 wk. Euglycemic clamp glucose disposal correlated positively and clamp hepatic glucose output correlated negatively with fasting triglyceride levels. In summary, fructose but not glucose feeding led to impaired insulin action in both the liver and peripheral tissues, effects that may
Apr 26, 2011. Its estimated that one in four Canadians has an unhealthy triglyceride level, which is linked with heart disease, heart attack, stroke and diabetes. The good news: High triglycerides, in large part, can be corrected though diet, weight loss and physical activity. According to a scientific statement issued this.. Together, a higher fasting-insulin level and an increased resistance to the action of insulin should greatly increase a childs risk of going on to develop diabetes. But what are the risk factors for having a high insulin level? What drives.. High triglycerides are often a sign of other. Sometimes high triglycerides are a sign of poorly controlled type 2 diabetes, The Mayo Clinic Diet book.. @ Triglycerides And Diabetes ★★ Diabetic Pain The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days.[ TRIGLYCERIDES AND DIABETES ] The REAL cause of Diabetes (and the solution),Triglycerides And Diabetes These diets consist of a giant amount of protein ...
Triglycerides are a fat in your blood. They are important to maintaining good health. However, if your triglycerides get out of control, you can put your heart at risk. People with high triglycerides usually have lower HDL (good) cholesterol and a higher risk of heart attack and stroke.. Calories you take in but dont burn immediately are converted to triglycerides to supply you with energy later. Your triglycerides level can be too high if you continue to consume more calories than you need. Of course, this causes obesity, too.. Other causes of elevated triglycerides, called hypertriglyceridemia, include diabetes, an underactive thyroid, kidney disease and drugs such as beta-blockers, some diuretics, estrogen, tamoxifen, steroids and birth control pills.. The common guidelines for triglyceride levels are the following: normal, less than 150 mg/dL; borderline-high, 150 to 199 mg-dL; high, 200 to 499 mg-dL, and very high, 500 mg-dL or more. Mg-dL stands for milligram per deciliter.. The primary ...
TY - JOUR. T1 - Comparing the serum triglyceride response to high-dose supplementation with either DHA or EPA among individuals with increased cardiovascular risk. T2 - The ComparED study. AU - Allaire, Janie. AU - Vors, Cécile. AU - Harris, William. AU - Jackson, Kristina Harris. AU - Tchernof, André. AU - Couture, Patrick. AU - Lamarche, Benoît. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Studies show that the reduction in serum triglyceride concentrations with long-chain omega-3 fatty acid supplementation is highly variable among individuals. The objectives of this study were to compare the proportions of individuals whose triglyceride concentrations are lowered after high-dose docosahexaenoic (DHA) and eicosapentaenoic acid (EPA), and to identify predictors of the response to both modalities. In a double-blind controlled crossover study, 154 men and women were randomized to three supplemented phases of 10 weeks each: 1) 2.7g/d of DHA, 2) 2.7g/d of EPA and 3) 3g/d of corn oil, separated by ...
TY - JOUR. T1 - Associations between dietary patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with regard to serum triglyceride levels. T2 - J-MICC study. AU - Nanri, Hinako. AU - Nishida, Yuichiro. AU - Nakamura, Kazuyo. AU - Tanaka, Keitaro. AU - Naito, Mariko. AU - Yin, Guang. AU - Hamajima, Nobuyuki. AU - Takashima, Naoyuki. AU - Suzuki, Sadao. AU - Nindita, Yora. AU - Kohno, Michiko. AU - Uemura, Hirokazu. AU - Koyama, Teruhide. AU - Hosono, Satoyo. AU - Mikami, Haruo. AU - Kubo, Michiaki. AU - Tanaka, Hideo. PY - 2016/9/6. Y1 - 2016/9/6. N2 - Interactions between dietary patterns and 2 β-adrenergic receptor (ADRβ) gene polymorphisms (ADRβ2 Gln27Glu and ADRβ3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35-69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 ...
Triglycerides are a type of fat found in the blood, and high levels are a risk factor for heart disease. Consequently, lower triglyceride levels is one of the approaches that should be included in heart-healthy lifestyle.
BACKGROUND: A ketogenic diet (KD), which has restricted carbohydrates, sufficient protein, and a very high fat content, causes the body to switch from a glucose-based metabolism to a ketone-based metabolism. The KD has been effective at reducing seizures in epileptic patients. Autism is comorbid with epilepsy and characterized by restricted and repetitive behaviors, low sociability, and deficits in communication. A strict version of the long-chain triglyceride (LCT) KD has been effective at reducing autistic symptoms in BTBR T+tf/J, an autistic model of mice. However, a more moderate and clinically relevant version of the LCT KD has been shown to be ineffective in this model. Recent studies suggest that a KD derived primarily from medium chain triglycerides (MCTs) will effectively reduce the severity of autistic symptoms. A MCT KD has been shown to cause an increase in ketone bodies, acetyl-CoA, and ATP similar to a LCT KD. However, MCTs are hydrolyzed faster than LCTs and provide more kilocalories per
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What is the connection between high triglycerides and diabetes? The purpose of triglycerides is to help with fat storage in your body, and are produced from carbohydrates which are part of your diet. Triglycerides store fat that is later used as an energy source by your body, and the compound insulin is needed for fat to be formed. Diabetes is a condition where your body does not handle carbohydrates and especially sugars very well, and there may not be enough insulin created by your body to meet your physical needs. Often making an effort to reduce triglycerides in your diet can minimize or even prevent diabetes.. A normal triglyceride level should be less than 150mg/dL, and anything higher than this could signal the start of diabetic changes. If you have high triglycerides and diabetes you can develop a condition called diabetic dyslipidemia, which can double your risk of heart disease. Changes in your diet and lifestyle can play a big role in managing both triglycerides and diabetes. ...
When three fatty acids are grouped together by a molecule of glycol, you have a triglyceride. Thus, you can also have short chain triglycerides (SCTs), medium chain triglycerides (MCTs) and long chain triglycerides (LCTs). The terms fatty acids and triglycerides are often used interchangeably.. It is important to know that the fats contained in the coconut are primarily saturated medium chain fatty acids (MCFA), also called medium chain triglycerides (MCT). MCFAs are distinguished from other fatty acids because they are more digestible and have greater solubility in water.. In comparison, the vast majority of other fats in our diet such as soybean oil, corn oil, canola oil, olive oil, lard and chicken fats are fully formed. of LCFA.. About 98 to 100% of the fatty acids you eat each day consists of LCFA. This type of fatty acid requires pancreatic digestive enzymes and bile for digestion. While MCFA contained in coconut fat can provide a quick and easy source of nutrition without resorting to ...
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This test measures the amount of triglycerides in your blood.. Triglycerides are one of several types of fats in your blood. Other kinds are LDL (bad) cholesterol and HDL (good) cholesterol. Knowing your triglyceride level is important, especially if you have diabetes, are overweight or a smoker, or are mostly inactive. High triglyceride levels may put you at greater risk for a heart attack or stroke. This test is part of a group of cholesterol and blood fat tests called a fasting lipoprotein panel, or lipid panel. This panel is recommended for all adults at least once every 5 years, or as recommended by your healthcare provider. Knowing your triglyceride level helps your healthcare provider suggest healthy changes to your diet or lifestyle. If you have triglycerides that are high to very high, your provider is more likely to prescribe medicines to lower your triglycerides or your LDL cholesterol. ...
Most stored body fat is in the form of triglycerides (triacylglycerols), which represent a highly concentrated form of energy. Most dietary fat is also triglycerides. But the body also makes triglycerides in the liver from carbohydrates. And the fastest, surest way to increase triglycerides in the blood is to eat a lot of sugar. Restricting sugar intake and supplementing with dietary antioxidants is often all that is required to return triglyceride levels to normal.. Both cholesterol and triglyceride levels can be reduced by taking supplementary red yeast rice extract, guggul resin extract, niacin, pantethine and phytosterols. Fish body oils are the only polyunsaturates known to lower triglycerides. Vegetable oils do not.. Also see BYPASS THE BYPASS: Restore Circulation Without Surgery (available at Amazon.com). Example of an arterial cleansing formula: https://vitamost.club/products/rtre-cardiovascular-nutrition-vitalized. ...
Triglyceride levels are usually measured whenever you have a blood test called a Lipid Profile. Everyone over 20 years should have their cholesterol checked at least every 5 years. Your doctor can check your cholesterol and triglyceride levels by taking a sample of blood, which is sent to a lab for testing. The Lipid Profile shows your triglyceride level, total cholesterol level, HDL cholesterol and LDL cholesterol levels ...
A sentence in the commentary for the abstract Increased serum triglyceride concentrations and abdominal adiposity were associated with increased mortality in women (1) should read as follows: Unfortunately, the study, which began in 1968, did not measure HDL cholesterol, low values of which might have explained the higher risk for hypertriglyceridemia ...
Epidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted pleiotropic analysis of genome-wide association studies of lung cancer (12 160 lung cancer case patients and 16 838 control subjects) and cardiovascular disease risk factors (blood lipids from 188 577 subjects, type 2 diabetes from 148 821 subjects, body mass index from 123 865 subjects, and smoking phenotypes from 74 053 subjects). We found that 6p22.1 (rs6904596, ZNF184) was associated with both lung cancer (P = 5.50x10(-6)) and blood triglycerides (P = 1.39x10(-5)). We replicated the association in 6097 lung cancer case patients and 204 657 control subjects (P = 2.40 × 10(-4)) and in 71 113 subjects with triglycerides data (P = .01). rs6904596 reached genome-wide significance in lung cancer meta-analysis (odds ratio = 1.15, 95% confidence interval = 1.10 to 1.21 ,: Pcombined = 5.20x10(
Omega 3 foods are recommended to be included in the triglycerides diet for anyone dealing with the problem of high triglycerides. Triglycerides basically come from two sources. The first one is our bodys natural ability to produce them as they are essential components of our body and they are the most common type of fat stored for energy.. The second source of triglycerides is from the food we eat. We get them from our diet in the fat and carbohydrates that we eat. They then get converted into a type of triglycerides our body can use and store.. At some point, we may experience a rise in the levels of triglycerides in the body as we age or due to certain medical conditions or as an effect of the drugs we take. But the usual cause of the elevation in our triglycerides is diet. Simply put, we eat too much and exercise too little.. But the good news is that the treatment to lower our triglycerides is actually pretty simple. Watch what you eat and move more! And ditch smoking while you are at it. ...
The purpose of this investigation was to examine the effects of exercise and diet on muscle triglyceride. Seven endurance-trained men completed a 120min cycling bout at 65% of V O2max in an attempt to lower muscle glycogen and triglyceride. Each subject then ingested an isocaloric, high-carbohydrate (HI-CHO; 83% of kcal) or high-fat (HI-FAT; 68% of kcal) diet for the ensuing 24 h. A 1600 kJ cycling time trial was completed following this 24-h dietary period. Muscle glycogen concentration before (571±38 vs. 599±41 mmol•kg dw-1) and after (241±36 vs. 285±41 mmol•kg dw-1) the 120-min cycling bout was not different (P,0.05) between the HI-CHO and HI-FAT trials, respectively. Muscle triglyceride concentration before (33.0±2.3 vs. 37.0±2.1 mmol•kg dw-1) and after (30.9±2.4 vs. 32.8±1.6 mmol•kg dw-1) the 120-min cycling bout was also not different between the HI-CHO and HI-FAT trials, respectively. In addition, muscle triglyceride did not decrease significantly during the cycling bout ...
In other words, the lower your triglycerides, or the higher your HDL, the smaller this ratio becomes. It is now believed that the triglycerides/HDL ratio is one of the most potent predictors of heart disease. A Harvard-lead study author reported: High triglycerides alone increased the risk of heart attack nearly three-fold. And people with the highest ratio of triglycerides to HDL - the good cholesterol - had 16 times the risk of heart attack as those with the lowest ratio of triglycerides to HDL in the study of 340 heart attack patients and 340 of their healthy, same age counterparts. The citation stated, the ratio of triglycerides to HDL was the strongest predictor of a heart attack, even more accurate than the LDL/HDL ratio. Supporting Citations:. Gaziano JM, Hennekens CH, ODonnell CJ, Breslow JL, Buring JE. Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation. 1997 Oct ...
Studies have shown lower triglyceride levels in those who eat low-carbohydrate diets as compared to those on low-fat diets, according to the National Center for Biotechnology Information. The...
If youve been keeping an eye on your blood pressure and cholesterol levels, theres something else you might need to monitor: your triglycerides. What Are Triglycerides? Triglycerides are a form of fat present in food, human body fat, and blood. Blood triglyceride levels are affected by dietary fat and are manufactured in the body from other energy sources, such ... Continue Reading ...
Define triglycerides. triglycerides synonyms, triglycerides pronunciation, triglycerides translation, English dictionary definition of triglycerides. triglycerides. Translations. English: triglycerides n., pl. triglicéridos, combinación que resulta de una molécula de glicerol con tres.
Fat in food is in the form of triglycerides. Its also the form in which your body stores fat. If you eat too much fat, too many calories or too much sugar, your body turns those nutrients into triglycerides, which may elevate blood levels and increase risk of heart disease. Watching your calories, as well as your fat and sugar intake, is necessary in order to bring blood triglyceride levels down. Consult your doctor to discuss your diet for high triglycerides.. ...
Triglycerides and cholesterol are both types of lipids, but triglycerides store unused calories for energy while cholesterol is used for cell membranes and some hormones. Since they are both lipids, they do not dissolve in the blood. Instead they need the help of lipoproteins for transport.. Up until recently, it wasnt clear how high levels of triglycerides caused a hardening of the arteries (Mayo Clinic). This condition is known as atherosclerosis, and when combined with high cholesterol may cause plaques to build up in the arteries. This places people at risk for coronary artery disease and heart attacks.. High triglycerides may be a result of obesity, type 2 diabetes, low thyroid, liver or kidney disease, beta blockers, birth control pills, diuretics, steroids, or the breast cancer drug tamoxifen.. New Studies. A report published May 6, 2010 found that high levels of triglycerides can cause heart disease. Up until this point, cholesterol levels were the main focus of heart disease ...
PubMed journal article [Insulin resistance: the role of intramuscular triglyceride and the importance of physical activity were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Jun 5, 2018 - Explore Megan Adamss board Foods that lower triglycerides, followed by 270 people on Pinterest. See more ideas about lower triglycerides, cholesterol diet, low cholesterol.
Youve probably gone to the doctor to have your cholesterol levels checked at some point. If you havent, now is the perfect time for you to learn more about the hidden heart dangers of cholesterol and other lipids, or types of fat in the blood. September is National Cholesterol Education Month, and results from a recent National Lipid Association (NLA) survey indicate Americans have a lot to learn.. You might have heard of LDL, bad cholesterol, and the health problems it can cause, but there are two more lipids the NLA wants you to know about: HDL, good cholesterol, and another important lipid, triglycerides.. Triglycerides are a type of fat produced by your body as it digests the things that you eat and drink. High levels of triglycerides (normal is below 150 mg/dL) can lead to serious illnesses including heart disease, kidney disease and stroke. The risk of developing heart disease doubles when triglycerides levels rise above 200 mg/dL. When triglycerides are above 200 mg/dL and HDL is ...
MCT Colada™ contains emulsified medium-chain triglycerides (MCTs) with a great-tasting natural pineapple/coconut flavor. Its emulsifica-tion allows for unparalleled absorption, and it will completely disperse when mixed into any liquid.. Medium-chain triglycerides are a unique form of fat requiring less energy and enzymes in order to be digested into its derivatives, medium chain fatty acids (MCFA) and monoglycerides. MCTs have some very impressive health benefits, which may include support for cognitive health, athletes (fuel for intense exercise), and metabolic function.. Made with non-GMO ingredients.. ...
MCT oil is a type of supplement containing medium-chain triglycerides. This is a type of fat with a medium-length chain of triglycerides. It occurs naturally in various sources like coconut oil, dairy foods, and palm kernel. MCT is available in four types: capric acid, caprylic acid, lauric acid, and caproic acid. The reason why mct olje is quite popular is because of the health benefits it carries. It is considered best for those who plan to shed off some extra pounds.. MCT oil helps in burning excess fat in your body. It also triggers the release of hormones that reduce appetite. If you want to shed off excess pounds fast, then MCT oil is a perfect supplement to use. It also lowers cholesterol levels in your body. High levels of cholesterol in your body are very dangerous. They can block your blood vessels, putting you at an increased risk of experiencing heart attacks.. Diabetes patients also stand ...
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Global Medium Chain Triglycerides (MCT) Market 2019 is expected to demonstrate an enormous growth in the upcoming years. The analysts also have analyzed drawbacks with on-going Medium Chain Triglycerides (MCT) trends and the opportunities which are devoting to the increased growth of the market. International Medium Chain Triglycerides (MCT) market research report provides the perspective of this competitive landscape of worldwide markets. The report offers particulars that originated from the analysis of the focused market. Also, it targets innovative, trends, shares and cost by Medium Chain Triglycerides (MCT) industry experts to maintain a consistent investigation.. The Medium Chain Triglycerides (MCT) report presents an estimation of the forecast from 2019 to 2025 and market history from 2014 to 2018. The information provided in the form of earnings likely to be produced in (USD million) year to year by Medium Chain Triglycerides (MCT) growth rate (CAGR). The report explains market ...
TY - JOUR. T1 - Feeding behavior in rats fed diets containing medium chain triglyceride. AU - Furuse, Mitsuhiro. AU - Choi, Yang Ho. AU - Mabayo, Remedios T.. AU - Okumura, Jun Ichi. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1992/10. Y1 - 1992/10. N2 - The effect of dietary medium chain triglyceride (MCT) on shortterm food intake was compared with the effect of long chain triglyceride (LCT) in rats. Corn oil and glyceryl tricaprylate were used as LCT and MCT sources, respectively. Rats were given diets containing 200 g MCT/kg diet (MCT diet), 100 g MCT + 100 g LCT/kg diet (ML diet), or 200 g LCT/kg diet (LCT diet) in Experiment 1. Cumulative food intake was determined every h for the first 12 h, then at 2-h intervals thereafter during the subsequent 12 h. As early as 1 h after feeding, cumulative food intake significantly decreased in MCT-fed animals in a dose-dependent fashion. In Experiment 2, rats were given a choice between MCT and LCT diets for 1 h to confirm ...
TY - JOUR. T1 - Acute resistance exercise attenuates fasting and postprandial triglyceridemia in women by reducing triglyceride concentrations in triglyceride-rich lipoproteins. AU - Zotou, Evelin. AU - Magkos, Faidon. AU - Koutsari, Christina. AU - Fragopoulou, Elizabeth. AU - Nomikos, Tzortzis. AU - Sidossis, Labros S.. AU - Antonopoulou, Smaragdi. PY - 2010/11. Y1 - 2010/11. N2 - A single bout of endurance exercise lowers fasting and postprandial triglyceride (TG) concentrations in both men and women, by reducing TG in triglyceride-rich lipoproteins (TRLs). The effect of resistance exercise on TRL-TG metabolism is not known; previous studies only measured total plasma TG concentrations and provide conflicting results. Furthermore, none has specifically examined women. We therefore sought to evaluate the effect of a single bout of resistance exercise on TRL-TG metabolism in women. We measured the concentrations of TG in total plasma and TRLs in the fasting state and during an oral fat ...
Save 25% Piping Rock - MCT Oil (Medium Chain Triglycerides) 16 Fluid Ounces MCT Oil Liquid 100% Pure Contains Caprylic & Capric Acid Keto Formula 24 Hour Support Energy* Performance* Vegetarian Formula Non-GMO Support your fitness goals, and your healthy lifestyle with Piping Rock® MCT Oil Liquid. MCT Oil is a great source of beneficial essential fatty acids including Caprylic and Capric Acids. This nutritional oil is derived from coconut and palm. A versatile liquid, MCT Oil is popular among athletes as an alternative to traditional energy and sports drinks. It doesnt contain any sugary additives, giving any workout a natural edge. Plus, the oil can be used in the kitchen to make salad dressings, sauces, and more. Grab a bottle and reap the benefits of MCT Oil today!
TY - JOUR. T1 - Central effects of humanin on hepatic triglyceride secretion. AU - Gong, Zhenwei. AU - Su, Kai. AU - Cui, Lingguang. AU - Tas, Emir. AU - Zhang, Ting. AU - Henry Dong, H.. AU - Yakar, Shoshana. AU - Muzumdar, Radhika H.. N1 - Publisher Copyright: © 2015 the American Physiological Society.. PY - 2015/8/5. Y1 - 2015/8/5. N2 - Humanin (HN) is an endogenous mitochondria-associated peptide that has been shown to protect against various Alzheimers diseaseassociated insults, myocardial ischemia-reperfusion injury, and reactive oxygen species-induced cell death. We have shown previously that HN improves whole body glucose homeostasis by improving insulin sensitivity and increasing glucose-stimulated insulin secretion (GSIS) from the β-cells. Here, we report that intraperitoneal treatment with one of HN analogs, HNG, decreases body weight gain, visceral fat, and hepatic triglyceride (TG) accumulation in high-fat diet-fed mice. The decrease in hepatic TG accumulation is due to increased ...
Title: Assessment and Clinical Relevance of Non-Fasting and Postprandial Triglycerides: An Expert Panel Statement. VOLUME: 9 ISSUE: 3. Author(s):Genovefa D. Kolovou, Dimitri P. Mikhailidis, Jan Kovar, Dennis Lairon, Borge G. Nordestgaard, Teik Chye Ooi, Pablo Perez-Martinez, Helen Bilianou, Katherine Anagnostopoulou and George Panotopoulos. Affiliation:Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.. Keywords:Postprandial triglycerides, non-fasting triglycerides, chylomicron remnants, very low density lipoprotein remnants, fat tolerance test, cardiovascular disease, statins, fibrates, nicotinic acid, type IIb hyperlipidemia. Abstract: An Expert Panel group of scientists and clinicians met to consider several aspects related to non-fasting and postprandial triglycerides (TGs) and their role as risk factors for cardiovascular disease (CVD). In this context, we review recent epidemiological studies relevant to elevated non-fasting TGs as a risk ...
Title: Assessment and Clinical Relevance of Non-Fasting and Postprandial Triglycerides: An Expert Panel Statement. VOLUME: 9 ISSUE: 3. Author(s):Genovefa D. Kolovou, Dimitri P. Mikhailidis, Jan Kovar, Dennis Lairon, Borge G. Nordestgaard, Teik Chye Ooi, Pablo Perez-Martinez, Helen Bilianou, Katherine Anagnostopoulou and George Panotopoulos. Affiliation:Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.. Keywords:Postprandial triglycerides, non-fasting triglycerides, chylomicron remnants, very low density lipoprotein remnants, fat tolerance test, cardiovascular disease, statins, fibrates, nicotinic acid, type IIb hyperlipidemia. Abstract: An Expert Panel group of scientists and clinicians met to consider several aspects related to non-fasting and postprandial triglycerides (TGs) and their role as risk factors for cardiovascular disease (CVD). In this context, we review recent epidemiological studies relevant to elevated non-fasting TGs as a risk ...
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Background: Type 2 diabetes mellitus (T2DM), is characterized by progressively increasing blood glucose levels due to insulin resistance and eventual insulin deficiency caused by loss of Beta cell function. To start with only postprandial (PPG) levels are raised and later on fasting plasma glucose (FBG) is also increased. It is noted that hypertension, dyslipidemias, weight gain and CVD are more prevalent among diabetics. Anti-diabetic agents used for control of diabetes mellitus must be able to improve blood glucose, blood pressure, lipid levels and body weight. Insulin and OHGs, both are effective treatment regimens in controlling hyperglycemic events. Objective: (1) To determine mean triglyceride, HDL and LDL levels in controlled type II diabetes mellitus patients. To compare mean triglyceride, HDL and LDL levels in controlled type II diabetes mellitus patients using oral hypoglycemic drugs with patient using insulin. Settings: Department of Medicine, Allied/DHQ hospital, Faisalabad. ...
Familial combined hyperlipidemia (FCHL) is a genetic disorder characterized by increases in plasma cholesterol and/or triglyceride, elevated apolipoprotein B, and heterogeneous low density lipoprotein (LDL). To examine the relation between plasma triglyceride concentrations and LDL heterogeneity, 13 hypertriglyceridemic FCHL patients with a predominance of small LDL (LDL subclass phenotype B) were treated with gemfibrozil. The distribution of LDL was determined using nondenaturing gradient gel electrophoresis and nonequilibrium density gradient ultracentrifugation. Mean plasma triglyceride levels decreased 55% (p , 0.01) after 3 months of treatment. Mean LDL peak particle size remained small (247 +/- 4 versus 249 +/- 5 A), and the correlation between change in plasma triglyceride concentrations and a change in LDL peak particle size was not significant. Individual changes in LDL flotation rate (Rf) were, however, inversely correlated with changes in triglyceride concentration (R = 0.60, p , ...
TY - JOUR. T1 - The effect of a low-cholesterol, high-polyunsaturate diet on serum lipid levels, apolipoprotein B levels and triglyceride fatty acid composition. AU - Durrington, P. AU - Bolton, CH. AU - Hartog, M. AU - Angelinetta, R. AU - Emmett, P. AU - Furniss, S. PY - 1977/8. Y1 - 1977/8. N2 - 1. (1) Seven healthy normolipaemic men aged 28-46 years (mean 33 years) were studied for four weeks on their usual diet, the mean polyunsaturated to saturated fat (P : S) ratio of which was approximately 0.23 and the cholesterol content 667 mg/day, and for four weeks on an isocaloric diet, containing similar proportions of protein, carbohydrate and fat, but with a mean P : S ratio of approximately 2.82 and a cholesterol content of 112 mg/day. 2. (2) Total serum cholesterol levels decreased by 18.7 ± 5.2% (mean ± SEM) on the polyunsaturated fat (PUF) diet. This was attributable to a similar reduction in serum low density lipoprotein (LDL) cholesterol. Serum very low density lipoprotein (VLDL) ...
TY - JOUR. T1 - The predictive role of serum triglyceride to high-density lipoprotein cholesterol ratio according to renal function in patients with acute myocardial infarction. AU - Korea Acute Myocardial Infarction Registry Investigators. AU - Kim, Jin Sug. AU - Kim, Weon. AU - Woo, Jong Shin. AU - Lee, Tae Won. AU - Ihm, Chun Gyoo. AU - Kim, Yang Gyoon. AU - Moon, Joo Young. AU - Lee, Sang Ho. AU - Jeong, Myung Ho. AU - Jeong, Kyung Hwan. AU - Ahn, Young Keun. AU - Chae, Sung Chull. AU - Kim, Jong Hyun. AU - Hur, Seung Ho. AU - Kim, Young Jo. AU - Seong, In Whan. AU - Choi, Dong Hoon. AU - Chae, Jei Keon. AU - Hong, Taek Jong. AU - Rhew, Jae Young. AU - Kim, Doo Il. AU - Chae, In Ho. AU - Yoon, Jung Han. AU - Koo, Bon Kwon. AU - Kim, Byung Ok. AU - Lee, Myoung Yong. AU - Kim, Kee Sik. AU - Hwang, Jin Yong. AU - Cho, Myeong Chan. AU - Oh, Seok Kyu. AU - Lee, Nae Hee. AU - Jeong, Kyoung Tae. AU - Tahk, Seung Jea. AU - Bae, Jang Ho. AU - Rha, Seung Woon. AU - Park, Keum Soo. AU - Kim, Chong ...
BACKGROUND: Triglyceride/high-density lipoprotein-cholesterol (TG/HDL-C) ratio was a surrogate marker of IR; however, the relationship of TG/HDL-C with IR might vary by ethnicity. This study aims to investigate whether lipid ratios-TG/HDL-C, cholesterol/high-density lipoprotein-cholesterol (TC/HDL-C) ratio, low-density lipoprotein-cholesterol/high-density lipoprotein-cholesterol (LDL-C/HDL-C)) could be potential clinical markers of insulin resistance (IR) and β cell function and further to explore the optimal cut-offs in a Chinese population with different levels of glucose tolerance.. METHODS: Four hundred seventy-nine subjects without a history of diabetes underwent a 75 g 2 h Oral Glucose Tolerance Test (OGTT). New-onset diabetes (n = 101), pre-diabetes (n = 186), and normal glucose tolerance (n = 192) were screened. IR was defined by HOMA-IR , 2.69. Based on indices (HOMA-β, early-phase disposition index [DI30], (ΔIns30/ΔGlu30)/HOMA-IR and total-phase index [DI120]) that indicated ...
TY - JOUR. T1 - Effect of increased physical activities of daily living on postprandial triacylglycerol concentrations in postmenopausal women. AU - Edamoto, Kanako. AU - Jung, Hyun Hun. AU - Kidokoro, Tetsuhiro. AU - Yanaoka, Takuma. AU - Kashiwabara, Kyoko. AU - Takahashi, Masaki. AU - Miyashita, Masashi. PY - 2015. Y1 - 2015. N2 - Limited evidence was available to support the effect of self-selected activities performed under free-living conditions on postprandial lipaemia, particularly for older adults. Thus, the aim of the present study was to examine the chronic effect of increased physical activity of daily living on postprandial triacylglycerol (TAG) in postmenopausal women. Twentyeight postmenopausal women, aged 71 ± 4 years (mean ± SD), were randomly divided into two groups: active (n=14) and control (n=14) groups. The participants in the active group were asked to increase their activities above their usual lifestyle levels for 4 weeks; freely deciding the duration and intensity of ...
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TY - JOUR. T1 - Attenuating effect of clock mutation on triglyceride contents in the ICR mouse liver under a high-fat diet. AU - Kudo, Takashi. AU - Tamagawa, Toru. AU - Kawashima, Mihoko. AU - Mito, Natsuko. AU - Shibata, Shigenobu. PY - 2007/8. Y1 - 2007/8. N2 - Energy homeostasis is subjected to a circadian control that synchronizes energy intake and expenditure. The transcription factor CLOCK, a key component of the molecular circadian clock, controls many kinds of rhythms, such as those for locomotor activity, body temperature, and metabolic functions. The purpose of the present study is to understand the function of the Clock gene during lipid metabolism in the liver using Clock-mutant mice. Clock-mutant mice with an ICR background were fed a high-fat diet for 13 weeks, and liver triglyceride, serum triglyceride, and serum free fatty acid levels were examined. Triglyceride content in the liver was significantly less increased in Clock-mutant mice on a high-fat diet compared to wild-type ...
Widely prescribed medications are often taken to influence all of these issues, especially when efforts to control them with diet, exercise, and proper weight have not been effective. However, some of these medications have unwanted side effects that remain a concern.. In this research, it was found that supplements of lipoic acid appeared to affect triglyceride levels through two pathways. After eating, lipoic acid supplementation increased the rate of disappearance of triglycerides in the bloodstream. And supplements also reduced the genetic expression of enzymes in the liver that synthesize triglycerides.. This is the first study that has identified the molecular targets by which lipoic acid can lower triglyceride levels, the researchers said, and to show the effect on liver enzymes resulting in less production of triglycerides. It also found that the mechanism of action of how lipoic acid can lower triglycerides appears separate and distinct from that provided by fibrate drugs, a group of ...
Genome-wide association studies have identified GALNT2 as a candidate gene in lipid metabolism, but it is not known how the encoded enzyme ppGalNAc-T2, which contributes to the initiation of mucin-type O-linked glycosylation, mediates this effect. In two probands with elevated plasma high-density lipoprotein cholesterol and reduced triglycerides, we identified a mutation in GALNT2. It is shown that carriers have improved postprandial triglyceride clearance, which is likely attributable to attenuated glycosylation of apolipoprotein (apo) C-III, as observed in their plasma. This protein inhibits lipoprotein lipase (LPL), which hydrolyses plasma triglycerides. We show that an apoC-III-based peptide is a substrate for ppGalNAc-T2 while its glycosylation by the mutant enzyme is impaired. In addition, neuraminidase treatment of apoC-III which removes the sialic acids from its glycan chain decreases its potential to inhibit LPL. Combined, these data suggest that ppGalNAc-T2 can affect lipid metabolism ...
Apolipoprotein E (APOE) plays a major role in lipid metabolism and inflammation. However, the association between APOE gene polymorphisms and serum triglyceride levels remains controversial. We tested the effects of APOE variants on triglyceride levels and their interactions with the inflammatory marker C-reactive protein (CRP) in a Taiwanese population. Two APOE single nucleotide polymorphisms (SNPs) rs429358 and rs7412 were genotyped by TaqMan Assay using real time PCR in 595 healthy subjects attending the clinic for routine visits. After adjustment for clinical covariates, subjects carrying the rs429358-TT genotype and non-ε4 alleles were found to have higher CRP levels, whereas those with rs7412-CC genotype and non-ε2 alleles had significantly higher total and low-density lipoprotein cholesterol levels (all P | 0.01). Using subgroup and interaction analyses, we observed significantly lower triglyceride levels in subjects carrying the rs429358-TT genotype and non-ε4 alleles in the low CRP group (P
QUESTION: Hi, I am familiar with gluten free eating but now better half needs to lower triglyceride levels so I was wondering if he could just eat gluten
Beneficial Effects on Energy, Atherosclerosis and Aging By Ward Dean, MD and Jim English Medium Chain Triglycerides (MCTs) are a unique form of dietary fat that
Medium Chain Triglycerides might be a saturated fat, but that doesnt mean theyre bad for you. In fact, far from it, says Peter Wilson. Fat is bad for you right? The supermarkets are all selling low fat products and we are all told how we should be reducing our cholesterol. The media has used a really broad brush here
What treatments for elevated triglycerides?. , Dietary advice is essential, and these are the first to apply, with the recommendations of lifestyle hygiene (increase in physical activity).. , You should also know that fish oils have a beneficial effect on triglyceride levels. We are no longer at the time of cod liver oil, all this is now in the form of capsules (dietary supplements).. , Medications are very effective. They are usually indicated when dietary recommendations are insufficient. These are fibrates, derivatives of fibric acid. They are lipid-lowering drugs (drugs that lower the level of lipids in the blood). They lower cholesterol and triglyceride levels, and are prescribed by a doctor.. By reducing the level of triglycerides, fibrates help reduce LDL cholesterol - called bad cholesterol. But in studies, fibrates have not always prevented myocardial infarction ... ...
In this interview with Dr. Alvin Berger, we will learn of the beneficial aspects of medium chain triglycerides from coconut and palm oil.
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The quality of MCT oil still matters! Mess-free powder for easy mixing With keto-friendly fiber for digestive support Made with MCTs from real coconuts Completely clean - no artificial sweeteners or junk. Try the delicious mocha flavor. Best Organic MCT oil: VIVA Naturals Organic MCT Oil. MCT powder is (quite obviously) a powdered form of MCT oil. MCT Collagen Powder, Grass Fed, Perfect for Keto, … ! Introducing Completely Keto Mocha MCT Oil Powder. If youve never used MCT oil before, start with just 1 teaspoon and slowly increase the amount as your body adjusts. Stay focused, think more clearly and give your cognitive function a boost with MCTs made from real coconuts. Rest assured that getting the Completely Keto MCT Oil Powder is the right decision. Thats right. Rest assured that getting the Completely Keto MCT Oil Powder is the right decision. When you drink Dr. Colberts Keto Zone MCT Oil Powder while following the Keto Zone Diet you will burn fat, optimize cognition and improve energy ...
TY - JOUR. T1 - Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations. AU - Kotronen, Anna. AU - Velagapudi, Vidya. AU - Yetukuri, Laxman. AU - Westerbacka, J.. AU - Bergholm, R.. AU - Ekroos, Kim. AU - Makkonen, J.. AU - Taskinen, M.-R.. AU - Orešič, Matej. AU - Yki-Järvinen, H.. PY - 2009. Y1 - 2009. N2 - Aims/hypothesis: The weak relationship between insulin resistance and total serum triacylglycerols (TGs) could be in part due to heterogeneity of TG molecules and their distribution within different lipoproteins. We determined concentrations of individual TGs and the fatty acid composition of serum and major lipoprotein particles and analysed how changes in different TGs and fatty acid composition are related to features of insulin resistance and abdominal obesity.Methods: We performed lipidomic analyses of all major lipoprotein fractions using two analytical platforms in 16 individuals, who ...
TY - GEN. T1 - Mathematically modeling the role of triglyceride production on leptin resistance. AU - Zhao, Yu. AU - Burkow, Daniel. AU - Song, Baojun. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Diet-induced obesity is becoming more common all over the world, which is increasing the prevalence of obesity-induced chronic diseases such as diabetes, coronary heart disease, cancer, and sleep apnea. Many experimental results show that obesity is often associated with an elevated concentration of plasma leptin and triglycerides. Triglycerides inhibit the passage of leptin across the blood-brain barrier (BBB) to signal the hypothalamus to suppress appetite. However, it is still not clear how triglyceride concentration affects leptin transport across the BBB and energy balance. In this paper, we propose a novel ordinary differential equations model describing the role of leptin in the regulation of adipose tissue mass. Analytical and numerical results are analyzed using biologically relevant parameter values. ...
Accelerated turnover of very low density lipoprotein triglycerides in chronic alcohol users. A possible mechanism for the up-regulation of high density lipoprotein by ethanol. doi: 10.1016/0021-9150(84)90194-1. The Reason: This one actually caught my attention not only because of the topic of the paper, but also because of its implications beyond the population studied. In short, frequent consumers of alcohol can present with an abnormally high HDL level, and this can eventually progress to high HDL along with high triglycerides. An unusual profile, for sure, and also one that can lead to thinking theyre healthier than they actually are, just by looking at their lipid profile. If you ask them to stop drinking for a while, their HDL goes back to reflecting their normal level. They found, in short, that this was likely due to rapid cycling of VLDL - both increased production, and increased clearance - resulting in higher HDL levels. I found this bit interesting, and perhaps especially relevant in ...
Triglyceride-rich lipoproteins as a causal factor for cardiovascular disease Peter P Toth1,2 1Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, 2Preventive Cardiology, CGH Medical Center, Sterling, IL, USA Abstract: Approximately 25% of US adults are estimated to have hypertriglyceridemia (triglyceride [TG] level ≥150 mg/dL [≥1.7 mmol/L]). Elevated TG levels are associated with increased cardiovascular disease (CVD) risk, and severe hypertriglyceridemia (TG levels ≥500 mg/dL [≥5.6 mmol/L]) is a well-established risk factor for acute pancreatitis. Plasma TG levels correspond to the sum of the TG content in TG-rich lipoproteins (TRLs; ie, very low-density lipoproteins plus chylomicrons) and their remnants. There remains some uncertainty regarding the direct causal role of TRLs in the progression of atherosclerosis and CVD, with cardiovascular outcome studies of TG-lowering agents, to date, having produced inconsistent
Predicting fatty acid composition of beef cattle at slaughter using weaner data would enable an early selection decision thereby saving time and costs associated with progeny testing. The aim of this study was to examine genetic and phenotypic correlations between triacylglycerol fatty acid composition at weaning and slaughter. Subcutaneous fat between the 12th and 13th rib interface was biopsied from 324 weaner calves sired by Angus, Belgian Blue, Hereford, Jersey, Limousin, South Devon and Wagyu. Fat from the same anatomical site was sampled from their carcasses at slaughter and analysed for fatty acids by gas-liquid chromatography. Statistical analysis was by Mixed Model and Maximum Likelihood procedures of Harvey (1990) after adjusting for genotype, sire nested within genotype, sex and location. Results indicated strongly positive genetic correlations between biopsy and carcass stearate (18:0), oleate (18:1n-9), total monounsaturated fatty acids (MUFA) and delta-nine desaturase enzyme index ...
THE EFFECTS OF DIETARY DIACYLGLYCEROLS ON POSTPRANDIAL LIPEMIA COMPARED TO TRIACYLGLYCEROLS IN COLLEGE AGED MALES AND FEMALES.. Purpose: The purpose of this study was to examine the difference in postprandial triglyceride response of subjects to triacylglycerols [canola oil] compared to diacylglycerols [Enova oil] to determine if consumption of diacylglycerols produces a lower postprandial triglyceride response. Background: Postprandial lipemia is an increase in duration and magnitude of triglycerides in the blood. An elevated postprandial response to lipids is associated with an increased risk of cardiovascular disease and metabolic syndrome, and metabolic syndrome independently increases the risk of cardiovascular disease and type 2 diabetes. The greater the magnitude of lipemia, the greater the risk. In a double-blind study on male subjects, consumption of 10-44g (about 2 tsp to 3 tbsp) of diacylglycerol oil compared to triacylglycerol oil resulted in a decreased serum TG response. The most ...
Essentialis, Inc., today announced Phase 2b trial results for its investigational compound DCCR demonstrating a reduction in triglyceride (TG) levels by 30 to 40 percent in patients whose TG levels exceeded 500 mg/dL (Very High Triglycerides VHTG). The study included an arm combining DCCR with fenofibrate treatment (Abbott Laboratories [email protected] (fenofibric acid)); in the combination arm, DCCR was shown to be additive to fenofibrate for all lipid fractions except LDL-C. In contrast, a 2009 study of VHTG patients using prescription omega-3 fatty acid in combination with fenofibrate revealed no clinically important change compared to fenofibrate alone(1).. More than five million people in the United States have very high TG levels. This population is at elevated risk for a number of diseases, including acute pancreatitis, diabetes and cardiovascular events (e.g., sudden death, myocardial infarction, acute coronary syndrome, revascularization, stroke and atrial fibrillation).. The results of this ...
TG and apoB secretion was elevated in hPten-ko mice. When hepatic TG was reduced by inhibition of diacylglycerol acyltransferase 1/diacylglycerol acyltransferase 2 or sterol regulatory element-binding protein-1c, both TG secretion and apoB secretion fell without changes in hepatic insulin signaling. Acute reconstitution of hPten reduced hepatic TG content, and both TG and apoB secretion fell within 4 days despite decreased hepatic insulin signaling. Acute depletion of hepatic Pten by adenoviral introduction of Cre into Pten floxed mice caused steatosis within 4 days, and secretion of both TG and apoB increased despite increased hepatic insulin signaling. Even when steatosis after acute Pten depletion was prevented by pretreatment with SREBP-1c antisense oligonucleotides, apoB secretion was not reduced after 4 days. Ex vivo results were in primary hepatocytes were similar.. ...
Coconuts are among the treasure-trove of whole foods that are beneficial to horses and their riders and owners. Coconut meal, and coconut oil provide important nutritional components for equine athletes. Coconut oil provides medium chain triglycerides, which are more rapidly absorbed and more quickly metabolized than the long chain triglycerides found in olive oil, vegetable oil, soy oil, and corn oil. Rather than being stored for fat, the body converts the medium chain triglycerides into fuel for muscles.
Medium-chain triglycerides (MCTs) are triglycerides whose fatty acids have an aliphatic tail of 6-12 carbon atoms. The fatty acids found in MCTs are called medium-chain fatty acids (MCFAs). Like all triglycerides, MCTs are composed of a glycerol backbone and three fatty acids. In the case of MCTs, 2 or 3 of the fatty acid chains attached to glycerol are of medium length. Rich sources for commercial extraction of beneficial MCTs include palm kernel oil and coconut oil. With regard to MCFAs, apart from the above listed straight chain (unbranched chain) fatty acids, side chain (branched chain) fatty acids also exist. Molecular weight analysis of milk from different species showed that while milk fats from all studied species were primarily composed of long-chain fatty acid (16 and 18 carbons long), approximately 10-20% of the fatty acids in milk from horses, cows, sheep, and goats were medium-chain fatty acids. Some studies have shown that MCTs can help in the process of excess calorie burning, ...
Using SSCP, we have identified a common variant within the LPL promoter, a T→G transition at position −93. This mutation was previously reported by Yang et al27 to occur in an individual who had a T-to-C substitution at nucleotide −39 of the LPL gene, but on the other chromosome. In a sample of healthy white men from the UK, the carrier frequency of this mutation is 3.4%. Several of the DNA samples used in the SSCP analysis were from individuals of Afro-Caribbean origin, and from the initial SSCP screening, it was obvious that the −93G allele was much more common in this group. Genotyping a sample of 91 Afro-Caribbeans showed that the −93G carrier frequency was 18-fold higher than in the whites (62.6% versus 3.4%).. Since the NPHSII sample had been genotyped for both mutations, it became apparent that there was very strong allelic association between −93G and N9 (83%; −=.91, P=.00001), with 17% of −93G alleles being on the wild-type D9 background (−93G/D9). We did not identify ...
An adequate daily supply of omega 3 fatty acids confers multiple health benefits upon you. Meeting your daily requirements of omega 3 is indeed crucial to optimum physical and mental health, especially in preventing (even reversing) heart disease. Omega 3 fats reverse heart disease, boost immune function, fight degenerative disease, help increase fertility, improve mental health and promote healthy skin.. Numerous studies have shown that there are benefits from taking fish oil supplements for triglyceride levels that are above normal. High blood triglyceride increases risk of heart attacks, and their control is an important thrust of primary prevention of heart disease.. Triglyceride levels can be reduced by cutting down on consumption of fats, alcohol and simple carbohydrates. Omega 3 fatty acides, particularly EPA and DHA, help further in bringing down levels.. Fish oils for triglyceride control act in a roughly dose dependent manner, with more fish oil intake being better. Taking 4.5 grams of ...
Organic Coconut MCT Oil is a source of healthy fats easily metabolized to meet both mental and physical energy requirements. Organic Coconut MCT Oil provides medium-chain triglycerides in a ratio of 60% C8 to 40% C10. It is a... Where can I buy Organic Coconut MCT Oil
Quite dramatic elevations in serum triglycerides are seen following ethanol ingestion,1 with levels over 100 mmol/l reported in chronic alcoholics.2 In the UK, patterns of ethanol ingestion are somewhat predictable. Typically, more units are consumed on Friday and Saturday nights than other nights.3 Burton-on-Trent is known internationally as the brewing capital of Great Britain,4 and was once responsible for brewing a quarter of all beer in the UK. It is not known whether consumption levels are reflected in this statistic, but nevertheless we hypothesised that the effect of weekend binge may be reflected in subsequent measurement … ...
|i|Obejective|/i|. To examine the discriminatory power of triglyceride (TG) and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) for insulin resistance (IR) in a normoglycaemic Chinese population. |i|Methods|/i|. The data were collected from 711 individuals. The normoglycaemic individuals were eventually included in the study (|i|n|/i| = 533, age: 62.8 ± 6.6 years, male: 56.8%), who were with a fasting plasma glucose < 6.1 mmol/L and without a history of diabetes. IR was defined as the upper quintile (≥1.6) of homeostasis model assessment of IR. Area under the receiver operating characteristic curve (AROC) was used to examine the discriminatory power. |i|Results|/i|. The discriminatory power of TG/HDL-C for IR was acceptable in women with a BMI < 24 kg/m|sup|2|/sup| or waist circumference < 80 cm (AROCs: 0.718 and 0.713, resp.); however, the discriminatory power was not acceptable in the obese women. TG/HDL-C was not an acceptable
Description 480ml amber dark glass jar 100% Pure MCT Oil with Caprylic Acid (C:8) and Capric Acid (C:10) MCT oil is one of the fastest sources of clean fuel for the body and brain. With fewer steps to convert into caloric energy than carbohydrates, it is hands down one of the best ways to power up your mental and physi
Sitnick et al. (1) provide compelling evidence that skeletal muscle-specific modulations of adipose triglyceride lipase (ATGL) expression in vivo in mice impacts intramyocellular triacylglycerol (IMTG) content with no measurable effects on other lipid species (diacylglycerols [DAG], ceramides, and long-chain acyl-coenzyme A) and insulin sensitivity. The authors speculate that the fatty acid (FA) cycle observed in cardiac muscle, with FA largely trafficking through IMTG before being consumed, may only occur in skeletal muscle during exercise. However, data from Jensen and colleagues (2) elegantly demonstrate that this cycle may be physiologically relevant in resting human skeletal muscle under normal feeding conditions. The findings in mice are also contrasting with the effect of ATGL on fat oxidation and insulin sensitivity observed in vitro in human primary myotubes (3).. The study by Sitnick et al. (1) raises a number of questions. It is first striking that long-term high-fat feeding did not ...
OBJECTIVES Paraoxanase 1 (PON1) plays a protective role against the oxidative modification of plasma lipoproteins and hydrolyzes lipid peroxides in human atherosclerotic lesions. Cumin is the dried seed of the herb Cuminumcyminum that is known as Zeera in Iran. Cumin seeds contain flavonoids which are now generally recognized to have antioxidant activity and improve the antioxidant system. So, they possibly modify PON1 activity and oxidized low density lipoprotein (oxLDL) level. The present study was aimed to evaluate the effects of cumin extract supplementation on oxLDL, paraoxanase 1 activity, FBS, total cholesterol, triglycerides, High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (Apo A1), and apolipoprotein B (Apo B)in the patients with hypercholesterolemia. METHODOLOGY A fasting venous blood sample was obtained from the voluntary persons before and 45±3 days after taking cumin. Glucose, total cholesterol, and triglycerides were ...
... as many kinds of triglycerides are known. The chain lengths of the fatty acids in naturally occurring triglycerides vary, but ... enzyme responsible for triglyceride biosynthesis Medium-chain triglycerides Lipid profile Lipids Vertical auto profile " ... A triglyceride would then be named according to general ester rules as, for example, "propane-1,2,3-tryl 1,2-bis((9Z)-octadec-9 ... Triglycerides are tri-esters consisting of a glycerol bound to three fatty acid molecules. Alcohols have a hydroxyl (HO-) group ...
Medium-chain triglycerides (MCTs) are triglycerides with two or three fatty acids having an aliphatic tail of 6-12 carbon atoms ... "Greater rise in fat oxidation with medium-chain triglyceride consumption relative to long-chain triglyceride is associated with ... Medium-chain triglycerides are generally considered a good biologically inert source of energy that the human body finds ... Due to their ability to be absorbed rapidly by the body, medium-chain triglycerides have found use in the treatment of a ...
June 2020). "Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical ... Because adipose tissue triglyceride is a major form of energy storage, the study of how ATGL regulation and dysregulation can ... Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that ... May 2006). "Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in ...
... large subunit is a protein that in humans is encoded by the MTTP gene. MTP encodes the ... Mar 1994). "Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride ... "Entrez Gene: MTTP microsomal triglyceride transfer protein". Luz JM, Lennarz WJ (1996). Protein disulfide isomerase: a ... 1996). "Mutations of the Microsomal Triglyceride-Transfer-Protein Gene in Abetalipoproteinemia". Am. J. Hum. Genet. 57 (6): ...
This test is used to identify dyslipidemia (various disturbances of cholesterol and triglyceride levels), many forms of which ... Typically the laboratory measures only three quantities: total cholesterol; HDL; Triglycerides. From these three data LDL may ... According to Friedewald's equation: [LDL] = [Total cholesterol] − [HDL] − [Triglycerides] /5 Other calculations of LDL from ... With that definition, Friedewald's equation yields: [VLDL] = [Triglycerides] /5 The alternative calculations mentioned above ...
Some studies have shown that medium-chain triglycerides (MCTs) can help in the process of excess calorie burning, and thus ... Rego Costa AC, Rosado EL, Soares-Mota M (2012). "Influence of the dietary intake of medium chain triglycerides on body ... St-Onge, MP; Jones, PJ (2002). "Physiological effects of medium-chain triglycerides: potential agents in the prevention of ... Clegg, M. E. (2010). "Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise ...
monographs.iarc.fr "Triglycerides". American Heart Association. Archived from the original on 27 August 2007. Retrieved 4 ... Frequent drinking of alcoholic beverages is a major contributing factor in cases of elevated blood levels of triglycerides. ...
Triglycerides + water --(enzyme esterase)--> glycerol + carboxylic acid Glycerol + ATP --(enzyme glycerol kinase)--> glycerol-3 ...
... is the presence of high amounts of triglycerides in the blood. Triglycerides are the most abundant fatty ... The word hypertriglyceridemia uses combining forms of hyper- + triglyceride + -emia, thus corresponding to "high triglyceride ... that hydrolyzes triglycerides in lipoproteins, leads to elevated levels of triglycerides in the blood. Lysosomal acid lipase ... The normal triglyceride level is less than 150 mg/dL (1.7 mmol/L). Once diagnosed, other blood tests are usually required to ...
In triglycerides (a neutral lipid), Nile red has an excitation maximum of about 515 nm (green), and emission maximum of about ... "Fluorescence SpectraViewer - Nile Red triglycerides". Thermo Fisher Scientific. 17 May 2017. Retrieved 6 March 2020. " ...
The triglycerides are powders, flakes, coarse powders, or granular or waxy lumps, oils or liquids. They are almost odorless. ... When the alcohol component is glycerol, the fatty acid esters produced can be monoglycerides, diglycerides, or triglycerides. ... Dietary fats are chemically triglycerides. Esters of fatty acids are colorless, although degraded samples are sometime appear ...
Cholesterol and triglycerides are lipids. lipoprotein A biochemical assembly that contains both proteins and lipids, bound to ...
... and high serum levels of triglycerides. Genetic testing can also confirm the disease, as mutations in the AGPAT2 gene is ...
The implications of being unable to store triglycerides include the inability to survive brief periods of starvation or times ... Recently, it has been suggested that FIT2 is a regulator of triglyceride biosynthesis. The overall importance of the FIT2 ... Fat storage-inducing transmembrane protein 2 (FITM2) affects the formation of triglyceride lipid droplets (LD). It is expressed ...
... is mainly composed of triglycerides. Each triglyceride contains three fatty acids. Butterfat triglycerides contain ... by lowering total LDL and triglyceride levels. A study by the US Department of Agriculture showed that vaccenic acid raises ...
ISBN 978-1-4649-6435-0. "Cats and Dietary Medium-Chain Triglycerides". Retrieved 2018-12-16. Curtis W. Dewey; Ronaldo C. da ... medium-chain triglycerides (can improve brain energy metabolism and decrease the amyloid protein buildup that results in brain ...
The elevated triglyceride levels (>5 mmol/L) are generally due to an increase in very low density lipoprotein (VLDL), a class ... Triglyceride level is an independent risk factor for cardiovascular disease and/or metabolic syndrome. Food intake prior to ... This form is due to high triglyceride level. Other lipoprotein levels are normal or increased a little.[citation needed] ... Hyperlipidemia is abnormally elevated levels of any or all lipids (fats, cholesterol, or triglycerides) or lipoproteins in the ...
Simple triglycerides are seen as well. A botanical alternative to spermaceti is a derivative of jojoba oil, jojoba esters, ... It is composed mostly of wax esters (chiefly cetyl palmitate) and a smaller proportion of triglycerides. Unlike other toothed ...
The triglycerides are not stable in HDL, but are degraded by hepatic lipase so that, finally, small HDL particles are left, ... Both lower LDL-C, some statins can raise HDL-C and lower triglycerides, but Mg supplements do both quite reliably. Hermansen K ... "HDL (Good), LDL (Bad) Cholesterol and Triglycerides". American Heart Association. 2021. Archived from the original on 28 July ... Kwiterovich PO (Dec 2000). "The metabolic pathways of high-density lipoprotein, low-density lipoprotein, and triglycerides: a ...
The reaction does not go to completion, and the product will be a mixture of triglycerides with different amounts of saturation ... In principle, when interesterification is applied to two pure triglycerides, each with three identical fatty acids (AAA and BBB ... Also, some of the new triglycerides produced by IE may be fractionated (separated) through controlled crystallization. ... typically a mixture of triglyceride. The process implies breaking and reforming the ester bonds C-O-C that connect the fatty ...
Because triglycerides cannot be absorbed by the digestive system, triglycerides must first be enzymatically digested into ... Lipid Monoglyceride Triglyceride IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected ... Diacylglycerol is a precursor to triacylglycerol (triglyceride), which is formed in the addition of a third fatty acid to the ... Industrial production is primarily achieved by a glycerolysis reaction between triglycerides and glycerol. The raw materials ...
High blood triglycerides may play a role. High levels of lipoprotein(a), a compound formed when LDL cholesterol combines with a ... January 2007). "Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 ... December 2021). "Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular ... Toth PP, Philip S, Hull M, Granowitz C (September 2019). "Association of Elevated Triglycerides With Increased Cardiovascular ...
It increased triglycerides accumulation in the liver; altered free fatty acids in the heart, in the adipose tissue, and in the ... heart; and reduced triglyceride levels in plasma. Glycosylation is a common posttranslational protein modifications, and almost ... coronary bypass patients contained significantly less sphingomyelin relative to phosphatidylcholine and higher triglycerides ...
Taylor, G. O. (1971). Serum triglycerides and fatty acids in kwashiorkor. The American journal of clinical nutrition, 24(10), ... Taylor, Grace Oladunni (1971-10-01). "Serum triglycerides and fatty acids in kwashiorkor". The American Journal of Clinical ...
There are various prescription fish oil products that have been approved and permitted by the FDA for decreasing triglyceride ... Prescription fish oil products having DHA work by raising LDL-C levels to reduce triglycerides, like fibrates. Heart experts ... 2018). "Assessment of omega-3 carboxylic acids in statin-treated patients with high levels of triglycerides and low levels of ... Prescription fish oils might only help when triglycerides reach a specific upper level. Prescription fish oil pills, capsules ...
Subsequently, the higher levels of fatty acids signal the liver cells to compound it to glycerol to form triglycerides. These ... triglycerides accumulate, resulting in fatty liver.[citation needed] Alcoholic hepatitis is characterized by the inflammation ...
Fish oil triglycerides was approved for use in the United States on July 27, 2018, and is available to patients on the US ... Although the use of fish oil triglycerides in children in the United States is experimental, the use of it in adults in Europe ... Fish oil triglycerides have also been associated with reduced mortality and antibiotic use during hospital stays. ... In European studies, fish oil triglycerides have been associated with a reduction in psoriasis, when contrasted to ...
ISBN 0-8493-9688-3, p. 86 Culp, T. W.; Harlow, R. D.; Litchfield, Carter; Reiser, Raymond (1965). "Analysis of triglycerides by ...
Marini A, Carulli G, Azzarà A, Grassi B, Ambrogi F (1989). "Serum cholesterol and triglycerides in hematological malignancies ...
Fats and oils are composed of triglycerides; three molecules of fatty acids are attached to a single molecule of glycerol. The ... In this reaction, the triglyceride fats are first hydrolyzed into free fatty acids, and then these combine with the alkali to ...
Trends in Elevated Triglyceride in Adults: United States, 2001-2012 ... NOTE: Elevated triglyceride is a triglyceride level greater than or equal to 150 mg/dl.. SOURCE: CDC/NCHS, National Health and ... NOTE: Elevated triglyceride is a triglyceride level greater than or equal to 150 mg/dL.. SOURCE: CDC/NCHS, National Health and ... NOTE: Elevated triglyceride is a triglyceride level greater than or equal to 150 mg/dL.. SOURCE: CDC/NCHS, National Health and ...
Triglycerides are a type of fat in your blood. Having a high level may raise the risk of heart disease, especially in women. ... High Blood Triglycerides (National Heart, Lung, and Blood Institute) * Triglycerides: Why Do They Matter? (Mayo Foundation for ... What are triglycerides?. Triglycerides are a type of fat. They are the most common type of fat in your body. They come from ... What causes high triglycerides?. Factors that can raise your triglyceride level include:. *Regularly eating more calories than ...
This study assessed the association between serum triglyceride levels and early atherosclerosis and vascular inflammation in ... Triglycerides and Residual Atherosclerotic Risk. Sergio Raposeiras-Roubin, MD, PHD; Xavier Rosselló, MD, PHD; Belén Oliva, MS; ... It is unknown whether triglyceride (TG) levels are associated with subclinical atherosclerosis and vascular inflammation ... Adverse CV events have been linked to high levels of triglycerides (TGs).[10,11] Current clinical practice guidelines for the ...
... N Engl J Med. 2008 Nov 27;359(22):2396-8. doi: 10.1056/NEJMc0805305. ...
LBXTR - Triglyceride (mg/dL). Variable Name: LBXTR. SAS Label: Triglyceride (mg/dL). English Text: Triglyceride (mg/dL). Target ... LBDTRSI - Triglyceride (mmol/L). Variable Name: LBDTRSI. SAS Label: Triglyceride (mmol/L). English Text: Triglyceride (mmol/L) ... In 2006, triglycerides were measured enzymatically in serum using the Roche Hitachi 717 and 912. In 2007, triglycerides were ... Because they are insoluble in water, the triglycerides are transported with other more polar lipids. Elevated triglyceride ...
... you have a good chance of lowering your triglycerides -- which, at the same time, lowers your chance of getting diabetes. ... Insulin also allows your body to use triglycerides for energy.. A common cause of high triglycerides is excess carbohydrates in ... Having high triglycerides -- a type of fat in the blood -- may be a sign you may have prediabetes or type 2 diabetes. Luckily, ... Your high triglycerides will follow and decrease as well. Your plan is likely to include both medication and lifestyle changes ...
But microbiota explain 4.5% of the variance in BMI, 6% in triglycerides, and 4% in HDL, independent of age, gender, and genetic ... Decreased gut microbial diversity is strongly associated with high body mass index (BMI) and triglyceride levels, as well as a ... "We found that these [low]-BMI-associated bacteria are also associated with lower levels of triglycerides and higher levels of ... The researchers also observed several new associations, including genus Eggerthella with increased triglycerides and decreased ...
JavaScript is disabled for your browser. Some features of this site may not work without it ...
When you eat, your body converts calories it does not use right away into triglycerides, which your body later stores in your ... Between meals, hormones release triglycerides to provide you with energy. ... Triglycerides are a type of lipid, or fat, found in your blood. ... Triglycerides are a type of lipid, or fat, found in your blood ... A triglyceride comprises three fatty acids attached to glycerol. The three types of fatty acids that compose triglycerides are ...
Includes genetic variants linked to lipid levels such as cholesterol and triglycerides ...
... this triglyceride is emollient and conditioning, leaving the skin smooth and supple. ... Widely used in cosmetics and especially in makeup, this triglyceride is emollient and conditioning, leaving the skin smooth and ... three in the case of triglycerides. Part of the lipid family, they are essential for life, but can also be used for their ...
... elevated triglyceride levels were associated with increased mortality rates. ... However, patients whose triglycerides increased 100 mg or more had a 39% higher probability of death in the study period. Thus ... In a study of patients with comorbid COPD and metabolic syndrome, elevated triglyceride levels were associated with increased ... The researchers noted that their study was small, and they did not intervene to correct triglycerides. Therefore, further ...
Fish Oil Triglycerides Injectable Emulsion) may treat, side effects, dosage, drug interactions, warnings, patient labeling, ... Omegaven (fish oil triglycerides) injectable emulsion, 5 g/50 mL and 10 g/100 mL (0.1 g/mL) is a white, homogenous, sterile ... Median triglyceride levels at baseline and the end of the study were 121 mg/dL and 72 mg/dL for Omegaven-treated patients ... Omegaven (fish oil triglycerides) is a lipid (fat) mixture that is used as a source of calories and fatty acids in children and ...
High Cholesterol? Triglycerides? There is a medication-free solution! How did you bring your cholesterol numbers under control ...
Fats travel in the blood as triglycerides and are stored in the cells as triglycerides. Each time a triglyceride moves into or ... Its this list I want to discuss, but first lets consider what triglycerides are and what they do.. Triglycerides are storage ... showed that my triglyceride level was 109 (and my HDL was 40). Then, on January 8, my triglyceride level was tested at 47 (and ... then simply lowering triglycerides wont really reduce the risk of heart disease unless however you reduce triglycerides also ...
You want to entangle me, how to control high blood pressure in old age you, the how to treat high cholesterol and triglycerides ... In the spirit world, it seemed that there was a how to treat high cholesterol and triglycerides city below, and looking down, ... Arrived! In front of it is the Tianya how to treat high cholesterol and triglycerides he flew into it, according to what was ... how to treat high cholesterol and triglycerides imprisoning the Sea of God, was also in the hall Ba whale, whats going on? ...
It consist of a mixture of triglycerides of saturated fatty acids, mainly of caprylic acid and of capric acid. They contain not ... Medium-chain triglycerides. It consist of a mixture of triglycerides of saturated fatty acids, mainly of caprylic acid and of ...
Years ago I became fascinated with the potential role of intramuscular triglycerides (abbreviated as IMTG) as a fuel source in ... and plasma triglycerides or plasma glucose (1). Plasma FFA and triglycerides are the primary precursors for the resynthesis of ... Intramuscular triglyceride (IMTG) is defined as lipid droplets stored within the cytoplasm of skeletal muscle fiber cells. This ... One challenge that stumped researchers for quite some time was how muscle triglyceride is broken down to be used as a fuel. ...
... has been used for over 20 years to lower triglyceride levels. There may be new uses for fenofibrate for the brain. ... Triglycerides. Fenofibrate (Tricor) has been used for over 20 years to lower triglyceride levels. There may be new uses for ... Fenofibrate to Lower Triglycerides:. Triglycerides are an important risk factor for heart disease, full stop! We know that ... Q. The doctor added fenofibrate to my meds because I had high triglycerides (400 plus). Within six weeks, my triglycerides were ...
What Are Triglycerides? Triglycerides are a form of fat present in food, human body fat, and blood. Blood triglyceride levels ... Triglycerides. Written By. BeWellBuzz. If youve been keeping an eye on your blood pressure and cholesterol levels, theres ... something else you might need to monitor: your triglycerides. ...
Krill Oil Vs Fish Oil Triglycerides. March 11, 2021. by [email protected] ... triglycerides in fish oil. An additional perk that krill oil has, is that its considered to be really stable and devoid of ...
There was no evidence of high triglyceride being associated with colorectal cancer risk. For people with Lynch syndrome, self- ... triglyceride and colorectal cancer risk.  Overall, 802 carriers were diagnosed with colorectal cancer at a median age of ... Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal ... Table 2 Diabetes mellitus, high cholesterol, and high triglyceride levels in people with Lynch syndrome included in the study. ...
Can high triglycerides cause thyroid problems?. Can high triglycerides cause thyroid problems?. High triglycerides can also be ... What food types cause high triglycerides?. Triglycerides happen when the body converts unneeded carbs into triglycerides, which ... High blood triglycerides usually do not cause any symptoms.. Why are high triglycerides a sign of metabolic syndrome?. High ... Age: Triglyceride numbers tend to creep up as you age.. What medications increase triglycerides?. Some antipsychotic ...
Cold plasma initiated valorisation of triglyceride containing feedstocks Author: Harris, Jonathan Stuart ISNI: 0000 0004 7971 ... Triglyceride decomposition primarily produces gaseous and liquid hydrocarbons, fatty acid esters and hydrogen, with other ... This thesis reviewed current methodologies for producing liquid fuels from triglycerides. With ever increasing demands for ...
High triglyceride levels can lead to obesity, diabetes... ... How To Lower Triglyceride Levels. *High Triglycerides as a ... Maintaining low cholesterol and triglyceride levels is essential for good health. ... 5 Ways to Reduce Your Cholesterol and Triglyceride Levels. *What to Do If Triglycerides Too High? - Updated Article With ... Maintaining low cholesterol and triglyceride levels is essential for good health. High triglyceride levels can lead to obesity ...
Learn more here to reduce your cholesterol and triglycerides. ... Control Cholesterol and Triglycerides in your body by obeying a ... Triglycerides are the most common type of fat found in the body and are a major source of energy. They come from the food that ... Cholesterol and triglycerides in your body It is normal to have cholesterol in the body as it is used for manufacturing cell ... Cholesterol and Triglycerides - these are two words that you would have probably heard a lot. This is primarily because more ...
After three months, they observed a significant decrease in serum triglycerides in the n-3 PUFA group (from 1.84 to 1.63 mmol/L ... Treatment with n-3 polyunsaturated acids (PUFA) may help hemodialysis (HD) patients lower serum triglyceride levels, according ... Close more info about N-3 Fatty Acids May Lower HD Patients Triglycerides ... Close more info about N-3 Fatty Acids May Lower HD Patients Triglycerides ...
Foods with fat and triglycerides Foods that lower triglyceride levels There are various foods and diets that can lower ... Prohibited foods for high triglycerides If we want to prevent our triglyceride levels from rising more than desired, it is ... What foods are prohibited for high triglycerides?. Throughout life it is important to take care of ourselves in all aspects to ... A good diet is key to this, so staying away from foods loaded with triglycerides is the best advice we can give you to have a ...
  • For adults aged 60 and over, declines in elevated triglyceride levels were seen in both men (from 39.9% during 2001-2004 to 24.8% during 2009-2012) and women (from 43.5% during 2001-2004 to 30.9% during 2009-2012). (cdc.gov)
  • Declines in elevated triglyceride levels were observed in overweight and obese men and women between 2001-2004 and 2009-2012. (cdc.gov)
  • Approximately one-quarter of adults aged 20 and over had elevated triglyceride levels during 2009-2012 ( Figure 1 ). (cdc.gov)
  • A greater percentage of men (28.7%) than women (21.5%) had elevated triglyceride levels. (cdc.gov)
  • In a study of patients with comorbid COPD and metabolic syndrome, elevated triglyceride levels were associated with increased mortality rates. (pharmacytimes.com)
  • The article discusses the correlation of elevated triglyceride levels with the development of coronary artery disease, then lists eight methods for reducing elevated triglyceride levels. (proteinpower.com)
  • Medical Conditions: Diabetes, kidney disease, low thyroid function, and liver disease are all associated with elevated triglyceride levels. (searchandrestore.com)
  • This is why starchy foods are bad for people with elevated triglyceride levels. (searchandrestore.com)
  • How can we support you with Medium-chain triglycerides? (imcdgroup.com)
  • Emerging science suggests that medium-chain triglycerides (MCT) may benefit the body in numerous ways. (acuatlanta.net)
  • Mannitol Starch Complex (from non-GMO corn), Stearic Acid, Silica, Modified Food Starch, Medium Chain Triglycerides and Cellulose. (vitanetonline.com)
  • In addition, medium-chain triglycerides (MCT) diversifies energy sources and prevent the oversaturation of one metabolic pathway. (ubikes.com)
  • Ubiquinol has been shown to be highly bioavailable and the addition of MCT Oil (medium chain triglycerides) to this product naturally improves its solubility and enhances intestinal absorption, thereby creating a product with superior biological value. (frysfood.com)
  • CDC a nalytic methods can identify vitamin E acetate, MCT oil (medium chain triglycerides), plant oils (long chain triglycerides), petroleum distillates (including mineral oil), diluent terpenes, cannabinoids, and nicotine in BAL fluid. (cdc.gov)
  • Lush purchase caprylic/capric triglycerides made from coconut oil. (lush.com)
  • It consist of a mixture of triglycerides of saturated fatty acids, mainly of caprylic acid and of capric acid. (imcdgroup.com)
  • Caprylic/capric triglyceride is a valid substitute of vegetable oils in that, being fully saturated, it resists oxidation. (beonmelab.com)
  • Metagenics MCT Oil features MCT oil concentrated to 90% caprylic (C8) and capric (C10) acid triglycerides. (acuatlanta.net)
  • Most of the patients with the highest fasting triglyceride levels also have elevated fasting blood sugars. (proteinpower.com)
  • Omegaven (fish oil triglycerides ) is a lipid (fat) mixture that is used as a source of calories and fatty acids in children and people who receive nutrition intravenously. (rxlist.com)
  • Omegaven (fish oil triglycerides) is a sterile, nonpyrogenic, white, homogenous emulsion for intravenous infusion as a supply of calories in patients with PNAC. (rxlist.com)
  • Fish oil triglycerides is a parenteral emulsion indicated as a source of calories and fatty acids in pediatric patients with parenteral nutrition-associated cholestasis (PNAC). (medscape.com)
  • My opinion, for what it's worth, is that elevated levels of triglycerides in fasting blood are a marker for heart disease, meaning that whatever really causes heart disease also causes an elevation of triglycerides. (proteinpower.com)
  • Avocados are a source of monounsaturated triglycerides, one of the three types of fats. (livestrong.com)
  • In saturated triglycerides, or saturated fats, most of the fatty acids are saturated, which technically means that each carbon atom has the maximum number of attached hydrogen atoms. (livestrong.com)
  • Triglycerides are storage fats composed of three fatty acid chains hooked onto a glycerol (a 3-carbon carbohydrate) molecule. (proteinpower.com)
  • Fats travel in the blood as triglycerides and are stored in the cells as triglycerides. (proteinpower.com)
  • The gastroenterologist I've seen says fenofibrate can bind with fats and lower triglycerides. (peoplespharmacy.com)
  • Triglycerides are fats consisting of 3 fatty acids covalently bonded to a glycerol molecule. (medscape.com)
  • Triglycerides are blood fats that are the usual storage form of lipids in the body. (baysport.com)
  • Medium-chain triglyceride supplementation may temporarily increase ketone production compared to common long-chain fats. (acuatlanta.net)
  • Triglyceride levels are decreased in hyperthyroidism, use of certain lipid-lowering drugs and malabsorption syndrome. (cdc.gov)
  • Triglycerides are a type of lipid, or fat, found in your blood. (livestrong.com)
  • Intramuscular triglyceride (IMTG) is defined as lipid droplets stored within the cytoplasm of skeletal muscle fiber cells. (bodybuilding.com)
  • Triglycerides are a different kind of lipid. (peoplespharmacy.com)
  • triglycerides (TG) - a kind of lipid (blood fat) that is generated by the liver. (i-base.info)
  • The only way to know if you have high triglycerides is through a blood test that will assess your lipid profile. (thirdplacebooks.com)
  • Serum triglyceride analysis lab test has proven useful in the diagnosis and treatment of patients with diabetes mellitus, nephrosis, liver obstruction, other diseases involving lipid metabolism, and various endocrine disorders. (labwork365.com)
  • The test for triglycerides is usually performed as part of a panel of tests called a lipid profile, which is useful in measuring cardiovascular and cerebrovascular risk levels, and the need for statin medication. (labwork365.com)
  • A 2008 study published in the Pakistan Journal of Biological Sciences found that apple cider vinegar helped improve serum lipid profile in both normal and diabetic rats by decreasing triglycerides and low-density lipoproteins while raising HDL levels. (healthycholesterolclub.com)
  • Adipocyte hypertrophy is a condition associated with larger than normal lipid droplets (LDs), the adipocyte organelles that store energy in the form of triglycerides. (europa.eu)
  • Would you like to take part in a Clinical Trial for a new investigational treatment for high triglycerides at no cost to you? (autocruitment.com)
  • While a new study published in Metabolic Syndrome and Related Disorders on October 29, 2014, indicates that comorbid COPD seems to have little effect on mortality, it found that elevated triglycerides do. (pharmacytimes.com)
  • After 22 years of follow-up, researchers found that elevated triglycerides were independently associated with mortality risk in patients with heart disease. (cardiosmart.org)
  • Alcohol is also a significant factor in elevating your triglyceride levels. (nutralegacy.com)
  • Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. (nature.com)
  • LDL is a calculated value: Total Cholesterol - HDL - (Triglycerides/5). (baysport.com)
  • Mean (SD) total cholesterol and median triglyceride concentrations were 8.1 Apronal (2.3) mmol/l and 3.5 (1.7) mmol/l, respectively, in the combined group with severe combined dyslipidaemia. (tsfaq.info)
  • Herbal Supplement support healthy Cholesterol and Triglycerides. (newvita.com)
  • EuroMedica Healthy Cholesterol and Triglycerides may be beneficial in supporting healthy cholesterol levels and providing you with powerful antioxidant protection. (drvitaminsolutions.com)
  • Healthy Cholesterol and Triglycerides can help assist with cardiovascular-related functions by providing you with a potent dose of Amla extract. (drvitaminsolutions.com)
  • Studies have highlighted the role of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio on subsequent cardiovascular events. (frontiersin.org)
  • Dyslipidemia is characterized by elevated triglyceride (TG) and reduced dense high-density lipoprotein cholesterol particles levels, and lower high-density lipoprotein cholesterol (HDL-C) levels in diabetic patients ( 7 , 8 ). (frontiersin.org)
  • For more than half of these individuals, there remains a need for further lowering of low-density lipoprotein cholesterol (LDL-C) or triglyceride (TG) levels. (medscape.com)
  • Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race/ethnicity? (cdc.gov)
  • TC), high triglycerides (TG), high low-density lipoprotein cholesterol (LDL-C) and low high-density lipopro- tein cholesterol (HDL-C) levels than non-obese men. (who.int)
  • Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. (bvsalud.org)
  • Observed patterns of relationships among relative apoliprotein A-1 level, high-density lipoprotein cholesterol, and triglycerides with incident coronary heart disease are consistent with patterns noted in clinical, laboratory, and transgenic animal research more capable of elucidating mechanisms of disease causation. (cdc.gov)
  • Your VLDL cholesterol particles carry the triglycerides to your tissues. (medlineplus.gov)
  • When triglycerides are present at a level of 60 or higher, several abnormal hidden particles begin to appear in the blood: very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), and, perhaps most important, "small" low-density lipoproteins (LDL). (lifeextension.com)
  • It also very effectively lowers levels of the hidden particles that triglycerides create, such as VLDL and small LDL. (lifeextension.com)
  • While LDL mainly carries cholesterol, VLDL carries triglycerides. (medlineplus.gov)
  • Having a high level of triglycerides can raise your risk of heart diseases , such as coronary artery disease . (medlineplus.gov)
  • Nearly two-thirds of all coronary heart disease cases in the US can be at least partly blamed on abnormal triglycerides. (lifeextension.com)
  • In other words, increasing triglycerides trigger a whole cascade of ill effects that cause coronary plaques to grow and that lead to heart attacks. (lifeextension.com)
  • In conjunction with high density lipoprotein and total serum cholesterol, a triglyceride determination provides valuable information for the assessment of coronary heart disease risk. (labwork365.com)
  • A high level of triglycerides can increase your risk of heart diseases, including coronary artery disease. (medlineplus.gov)
  • Widely used in cosmetics and especially in makeup, this triglyceride is emollient and conditioning, leaving the skin smooth and supple. (lush.com)
  • Because they are insoluble in water, the triglycerides are transported with other more polar lipids. (cdc.gov)
  • Decreased gut microbial diversity is strongly associated with high body mass index (BMI) and triglyceride levels, as well as a low level of high-density lipoproteins (HDL), according to results of the first study to determine how the gut microbiome relates to body weight and blood lipids. (medscape.com)
  • True, lipids and carbohydrate are the major fuels for muscular work and it is generally correct to think that the fat and carbohydrate oxidized (burned) during exercise are derived predominantly from triglyceride (fat) and glycogen stored within the body. (bodybuilding.com)
  • After three months, they observed a significant decrease in serum triglycerides in the n-3 PUFA group (from 1.84 to 1.63 mmol/L) compared with the control arm (from 1.89 to 2.07 mmol/L). They observed no significant effect on other lipids or lipoproteins. (renalandurologynews.com)
  • IMSEAR at SEARO: Examination stress: changes in serum cholesterol, triglycerides and total lipids. (who.int)
  • Serum cholesterol, triglycerides and total lipids were estimated in twelve students exposed to varying degree of examination stress. (who.int)
  • Serum cholesterol and triglycerides exhibited a rise proportional to degree of examination stress whereas total lipids exhibited an initial rise followed by a fall. (who.int)
  • If this is the case, then simply lowering triglycerides won't really reduce the risk of heart disease unless however you reduce triglycerides also reduces the real risk. (proteinpower.com)
  • Apple cider vinegar also helps reduce triglycerides and cholesterol levels. (healthycholesterolclub.com)
  • A triglyceride level of 150 mg/dL or higher is also a risk factor for metabolic syndrome . (medlineplus.gov)
  • People with metabolic syndrome (high cholesterol, triglycerides, blood glucose and blood pressure along with a large waistline) are especially likely to benefit from fenofibrate. (peoplespharmacy.com)
  • High triglycerides, or a score above 149 mg/dL, is a risk factor for metabolic syndrome, which increases your risk for serious conditions, including diabetes and heart disease, according to the American Heart Association. (searchandrestore.com)
  • Why are high triglycerides a sign of metabolic syndrome? (searchandrestore.com)
  • The first is an ode to what you can do to lower your triglyceride levels if that is an issue, and what metabolic effects can be expected if you do? (180degreehealth.com)
  • And according to the Harvard Medical School, having high triglyceride levels may be an indication of a metabolic syndrome such as diabetes and pancreatitis. (thirdplacebooks.com)
  • Your high triglycerides will follow and decrease as well. (webmd.com)
  • Beneficial high-density lipoprotein (HDL) levels decrease as triglyceride levels increase. (lifeextension.com)
  • With Triglyceride OMEGA, you will notice a decrease in your dog's scratching and an increased healthy and shiny coat. (chewy.com)
  • We are proposing a randomized trial of 500 women, on HRT for at least two years, aged 52-60 years, and three or more years postmenopausal to test whether reduction in waist circumference, triglycerides, dense LDLc, number of LDL particles, CPR, PAI-I by aggressive diet exercise, versus a health education control will decrease progression or result in regression of measures of subclinical vascular disease. (grantome.com)
  • The primary endpoint will be a 20 percent or at least a 20 mg decrease in triglyceride levels, a 5 cm decrease in waist circumference, and a 10 percent decrease in LDLc. (grantome.com)
  • Just as Omega-3 fatty acids found in fish such as salmon and tuna help raise your HDL (good cholesterol) and lower your LDL (bad cholesterol), Omega-3s can also lower your triglycerides. (nutralegacy.com)
  • By lowering both your cholesterol and triglycerides, Omega-3 fatty acids are one of the best ways to prevent heart disease. (nutralegacy.com)
  • Triglycerides are fatty acid esters of glycerol that have three hydroxyl groups. (cdc.gov)
  • Triglyceride decomposition primarily produces gaseous and liquid hydrocarbons, fatty acid esters and hydrogen, with other products not observed thermochemically (e.g. acetol and formic acid). (bl.uk)
  • The three types of fatty acids that compose triglycerides are saturated, monounsaturated and polyunsaturated fatty acids. (livestrong.com)
  • Obesity: Excess weight generally increases the blood level of triglycerides. (searchandrestore.com)
  • High triglyceride levels can lead to obesity, diabetes and even kidney failure. (nutralegacy.com)
  • Not only will this lower your triglyceride levels but limiting your sugar and lower your chances for obesity which correlates with your cholesterol. (nutralegacy.com)
  • CONCLUSIONS: Maternal prepregnancy obesity, GWG, and serum triglycerides are associated with longitudinal BMI trajectories in early childhood that may increase disease risk in later life. (rti.org)
  • Elevated triglyceride is associated with cardiovascular disease ( 1 ). (cdc.gov)
  • It is important to test the levels of triglycerides in the body as a high amount can contribute to the development of cardiovascular disease. (labwork365.com)
  • Some people will also need to take cholesterol medicines to lower their triglycerides. (medlineplus.gov)
  • Luckily, with some effort, you can lower your weight and increase your exercise which can lower your risk for both high triglycerides and diabetes . (webmd.com)
  • You can reverse your tracks by following the exercise and meal plan your doctor recommends to lower your triglycerides and by taking prescribed medicine. (webmd.com)
  • We found that these [low]-BMI-associated bacteria are also associated with lower levels of triglycerides and higher levels of HDL. (medscape.com)
  • He what is good to lower high cholesterol Antes of Immortals after the Rebecka how to treat high cholesterol and triglycerides the forces decided that he had no chance of escaping, and gave up their investigation Plus he was just a flash in the pan at the time, so he hasn't been recognized for years. (jewishledger.com)
  • Fenofibrate (Tricor) has been used for over 20 years to lower triglyceride levels. (peoplespharmacy.com)
  • Fenofibrate is an old drug that is prescribed to lower triglycerides ( TG ). (peoplespharmacy.com)
  • To lower your triglycerides make sure to avoid sodas, fruit juice and other sugary candies and treats. (nutralegacy.com)
  • Instead of regular cheeses and whole milk, use fat-free or low-fat cheeses and milk in your recipes As you can see, taking steps to lower your blood cholesterol and triglyceride levels isn't a difficult thing to do. (nestle-family.com)
  • There are various foods and diets that can lower triglyceride levels and with this the fat cells of our body. (ksusentinel.com)
  • The standard US guidelines for triglycerides and cholesterol, called the Adult Treatment Panel III, recommend that triglycerides be kept at a level of 150 mg/dL or lower. (lifeextension.com)
  • Niacin (vitamin B3) is another powerful way to lower triglycerides. (lifeextension.com)
  • In effect, they lower the "glycemic index" of foods and thus can indirectly lower triglycerides. (lifeextension.com)
  • Since statins help lower cholesterol and reduce risk for heart events, they may minimize the impact of triglycerides heart attack and death. (cardiosmart.org)
  • Low Conscientiousness and traits related to impulsivity were associated with lower HDL cholesterol and higher triglycerides. (elsevier.com)
  • If you are deciding whether or not to take garlic to lower your triglyceride levels, you may want to take into consideration the possible side effects of consuming large amounts of garlic. (healthfully.com)
  • We've rounded up some of the foods that can lower triglycerides, and there are plenty of whole foods on the list. (healthycholesterolclub.com)
  • Here are 8 top foods that may help lower triglyceride levels. (healthycholesterolclub.com)
  • While nutrition probably has the most significant impact on triglycerides, exercise can also lower your levels. (healthycholesterolclub.com)
  • Maternal serum triglycerides were negatively associated with BMI trajectories departing from lower birth sizes. (rti.org)
  • Plasma samples and liver biopsy specimens were obtained before and after weight gain and during and after weight loss for determination of free fatty acid, triglyceride, and lipoprotein concentrations. (avma.org)
  • In addition, expanded pork skin decreased blood cholesterol and triglyceride concentrations, which may justify further research on this area. (researchgate.net)
  • Exercise also lowers your triglyceride levels, especially when done first thing in the morning. (nutralegacy.com)
  • The muscle fibers use either the stored IMTG or glycogen or it is transported to them via circulation in the form of plasma free fatty acids (FFA), and plasma triglycerides or plasma glucose (1). (bodybuilding.com)
  • Anything with a high glucose level, like simple sugars, will spike your triglycerides. (nutralegacy.com)
  • In the current study, we report the associations between self-reported diagnosis of diabetes mellitus, high cholesterol and high triglyceride, and the risk of colorectal cancer for people with Lynch syndrome, using a large dataset from the Colon Cancer Family Registry. (nature.com)
  • evaluar los factores de riesgo del diagnóstico de enfermería Riesgo de glucemia inestable en ancianos con diabetes mellitus tipo 2. (bvsalud.org)
  • If you are an individual with high cholesterol and high triglycerides your chances of developing heart disease are even worse. (nutralegacy.com)
  • The good news is that following a healthy diet helps in reducing high blood cholesterol and triglycerides and also prevents them from increasing. (nestle-family.com)
  • Your blood cholesterol and triglyceride values will improve and you'll also more likely feel lighter, healthier and more energetic. (nestle-family.com)
  • Restless leg syndrome is found among people with High blood cholesterol and triglycerides, especially for people who are female, 60+ old. (ehealthme.com)
  • The study analyzes which people have Restless leg syndrome with High blood cholesterol and triglycerides. (ehealthme.com)
  • It is created by eHealthMe based on reports of 660 people who have High blood cholesterol and triglycerides from the Food and Drug Administration (FDA), and is updated regularly. (ehealthme.com)
  • 660 people who have High Blood Cholesterol And Triglycerides and Restless Leg Syndrome are studied. (ehealthme.com)
  • What is High blood cholesterol and triglycerides? (ehealthme.com)
  • High blood cholesterol and triglycerides is found to be associated with 3,429 drugs and 3,383 conditions by eHealthMe. (ehealthme.com)
  • Your body changes these extra calories into triglycerides and stores them in fat cells. (medlineplus.gov)
  • When your body needs energy, it releases the triglycerides. (medlineplus.gov)
  • Insulin also allows your body to use triglycerides for energy. (webmd.com)
  • When you eat, your body converts calories it does not use right away into triglycerides, which your body later stores in your fat cells. (livestrong.com)
  • As far as I can tell there is no firm data showing precisely how elevated levels of triglycerides actually drive the development of heart disease, but there is a considerable body of data demonstrating a strong correlation between elevated triglycdride levels and heart disease. (proteinpower.com)
  • Triglycerides are a form of fat present in food, human body fat, and blood. (bewellbuzz.com)
  • Triglycerides happen when the body converts unneeded carbs into triglycerides, which are a type of fat. (searchandrestore.com)
  • Alcohol prevents your body from burning fat and increases your liver's production of triglycerides. (nutralegacy.com)
  • Cholesterol and triglycerides in your body It is normal to have cholesterol in the body as it is used for manufacturing cell membranes and some hormones, and also serves other needed bodily functions. (nestle-family.com)
  • Triglycerides are the most common type of fat found in the body and are a major source of energy. (nestle-family.com)
  • First of all, we must bear in mind that triglycerides are blood fat that makes our body has energy. (ksusentinel.com)
  • Triglycerides are the chemical form of fat found in food and in your body. (healthfully.com)
  • Triglycerides is the storage form of fat in the body and is used as a major source of energy. (labwork365.com)
  • Most triglycerides are found in the fat tissue in the body, so a small amount can circulate in the blood. (labwork365.com)
  • If you are overweight , losing 5% to 10% of your body weight will do wonders for your health in general and triglyceride levels in particular. (healthycholesterolclub.com)
  • But what exactly are triglycerides, and how do they work in your body? (healthycholesterolclub.com)
  • Diet plays a major role in the production of triglycerides in your body. (healthycholesterolclub.com)
  • MCT (medium-chain triglyceride) oil is particularly effective because it contains isolated fatty acids that are more easily digested by the body. (naturalnews.com)
  • Triglycerides are the most common type of fat in the body. (medlineplus.gov)
  • The excess calories that your body doesn't immediately need are changed into triglycerides, which are stored in fat cells. (medlineplus.gov)
  • A low-carbohydrate diet is one way to get triglycerides down ( PLoS One , Jan. 14, 2020 ). (peoplespharmacy.com)
  • Having high triglycerides -- a type of fat in the blood -- may be a sign you may have prediabetes or type 2 diabetes. (webmd.com)
  • Weighted Cox regression was used to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for the associations between self-reported type 2 diabetes, high cholesterol, triglyceride and colorectal cancer risk. (nature.com)
  • High triglycerides can also be a sign of: Type 2 diabetes or prediabetes. (searchandrestore.com)
  • Now that he has personally arrived in the desert restricted area, Lawanda Menjivar is already ready to fight high blood pressure high cholesterol high triglycerides alone! (jewishledger.com)
  • By managing risk factors like high cholesterol, high triglycerides and high blood pressure, patients can improve heart health and reduce risk for life-threatening heart events. (cardiosmart.org)
  • The rise in serum cholesterol and triglycerides seems to be due to stress induced changes in hormonal levels and peripheral lipolysis respectively. (who.int)
  • While exercise and avoiding alcohol and simple sugars is a start, better eating habits in general will improve both your cholesterol and triglycerides. (nutralegacy.com)
  • Aim We performed genome-wide and transcriptome-wide profiling to identify genes and single nucleotide polymorphisms (SNPs) associated with the response of triglycerides (TG) to exercise training. (bmj.com)
  • Even if you cant get to the point where exercise impacts your triglycerides, dont let that discourage you. (healthycholesterolclub.com)
  • High triglycerides (hypertriglyceridemia) refers to raised levels of blood triglycerides and if the levels of this fat in the blood becomes too high, it can lead to heart disease, acute pancreatitis, along with other serious conditions. (autocruitment.com)
  • Hypertriglyceridemia, a condition in which triglyceride levels are elevated, is a common disorder in the United States. (medscape.com)
  • Hypertriglyceridemia is usually asymptomatic until triglycerides are greater than 1000-2000 mg/dL. (medscape.com)
  • There is undoubtedly a correlation between elevated levels of triglycerides in a fasting blood sample and the risk for heart disease. (proteinpower.com)
  • Triglycerides are an important risk factor for heart disease, full stop! (peoplespharmacy.com)
  • Triglycerides are a major cause of heart disease, and one that is frequently ignored or neglected. (lifeextension.com)
  • The familial variety, which is usually responsible for triglyceride levels of 400 mg/dL or greater, is relatively uncommon, and may or may not contribute to heart disease risk. (lifeextension.com)
  • At what level, however, do triglycerides begin to add to heart disease risk? (lifeextension.com)
  • Like elevated triglycerides, low HDL can be a powerful cause of heart disease. (lifeextension.com)
  • People with heart disease should keep a close eye on triglyceride levels, based on a recent study that independently links even slightly elevated triglycerides to increased risk of death. (cardiosmart.org)
  • Many studies have linked high triglycerides to increased risk for heart disease and death, but the topic is highly controversial. (cardiosmart.org)
  • Based on findings, authors conclude that triglycerides alone have a big impact on mortality risk for patients with heart disease. (cardiosmart.org)
  • As a supplement, the stinky herb has been studied as a treatment for conditions related to heart disease, including high triglyceride levels in the blood. (healthfully.com)
  • High levels of triglycerides in the blood are associated with an increased risk of heart disease, according to the American Heart Association. (healthfully.com)
  • Excess triglycerides appear to be the predominant?cause of insulin resistance, not spikes in insulin from a high-carbohydrate meal. (180degreehealth.com)
  • But microbiota explain 4.5% of the variance in BMI, 6% in triglycerides, and 4% in HDL, independent of age, gender, and genetic risk factors, they add. (medscape.com)
  • There was no evidence of high triglyceride being associated with colorectal cancer risk. (nature.com)
  • The drug she took - now known as Vascepa - proved to dramatically reduce the risk of cardiovascular "events" by lowering very high levels of triglycerides by 33 percent. (chihealth.com)
  • This study, along with many others, suggest that high triglycerides increase risk of death. (cardiosmart.org)
  • Compared to the lowest 10%, those who scored in top 10% on Impulsivity had a 2.5 times greater risk of exceeding the clinical threshold for elevated triglycerides (OR=2.51, CI=1.56-4.07). (elsevier.com)
  • In 2007, triglycerides were measured in serum using Roche Modular P chemistry analyzer. (cdc.gov)
  • Measurement of triglycerides by automated analyzer. (tamu.edu)
  • You can eat saturated fat to your heart's content and still markedly reduce your triglyceride levels as long as you rigidly reduce your carbs. (proteinpower.com)
  • Needless to say, I'm not a fan of trans fat, but many patients have brought about tremendous reduction of their triglyceride levels while eating a lot of processed food by simply restricting their carbs. (proteinpower.com)
  • A common cause of high triglycerides is excess carbohydrates in your diet. (webmd.com)
  • Because the excess carbohydrate in your diet is what gets later converted into triglycerides, it is essential to follow a low-carbohydrate diet. (healthycholesterolclub.com)