The causative agent of venereal and non-venereal syphilis as well as yaws.
A genus of microorganisms of the order SPIROCHAETALES, many of which are pathogenic and parasitic for man and animals.
A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.
Infections with bacteria of the genus TREPONEMA.
Syphilis serodiagnosis employing as the antigen Treponema pallidum obtained from rabbit syphilis orchitis. Treponemes are kept alive for a few hours in a special medium. When syphilitic serum and complement are added and incubated, the treponemes are immobilized, i.e., stop moving.
Serologic tests for syphilis.
A systemic non-venereal infection of the tropics caused by TREPONEMA PALLIDUM subspecies pertenue.
A species of bacteria in the family SPIROCHAETACEAE, frequently isolated from periodontal pockets (PERIODONTAL POCKET).
Syphilis acquired in utero and manifested by any of several characteristic tooth (Hutchinson's teeth) or bone malformations and by active mucocutaneous syphilis at birth or shortly thereafter. Ocular and neurologic changes may also occur.
The primary sore of syphilis, a painless indurated, eroded papule, occurring at the site of entry of the infection.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)
Cutaneous lesions arising from infection with Treponema pallidum. In the primary stage, 18-21 days following infection, one or more chancres appear. If untreated, the subsequent stages of the disease appear as syphilids. These eruptions are superficial, nondestructive, exanthematic, transient, macular roseolas that may later be maculopapular or papular polymorphous or scaly, pustular, pigmented eruptions.(Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p409)
Substances elaborated by bacteria that have antigenic activity.
Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)
Serologic assay that detects antibodies to Treponema pallidum, the etiologic agent of syphilis. After diluting the patient's serum to remove non-specific antibodies, the serum is mixed on a glass slide with Nichol's strain of Treponema pallidum. An antigen-antibody reaction occurs if the test is positive and the bound antibodies are detected with fluoresceinated antihuman gamma-globulin antibody.
A family of spiral bacteria of the order SPIROCHAETALES.
Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine.
A genus of flexible, spiral rods found in hydrogen sulfide-containing mud, sewage, and polluted water. None of the species properly referred to in this genus are pathogenic.
An order of slender, flexuous, helically coiled bacteria, with one or more complete turns in the helix.
Latent syphilis is a stage of the sexually transmitted infection Syphilis, characterized by the absence of symptoms, but with positive serological tests, which can be further divided into early and late latency, depending on the duration and the potential for progression to tertiary syphilis.
Proteins found in any species of bacterium.
The external and internal organs related to reproduction.
A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.
An acute or chronic GINGIVITIS characterized by redness and swelling, NECROSIS extending from the interdental papillae along the gingival margins, PAIN; HEMORRHAGE, necrotic odor, and often a pseudomembrane. The condition may extend to the ORAL MUCOSA; TONGUE; PALATE; or PHARYNX. The etiology is somewhat unclear, but may involve a complex of FUSOBACTERIUM NUCLEATUM along with spirochetes BORRELIA or TREPONEMA.
Antibodies, especially IGE, that bind to tissue of the same species so that ANTIGENS induce release of HISTAMINE and other vasoactive agents. HYPERSENSITIVITY is the clinical manifestation.
Proteins isolated from the outer membrane of Gram-negative bacteria.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
Techniques used in studying bacteria.
Inflammation of a TESTIS. It has many features of EPIDIDYMITIS, such as swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS and then the TESTIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.
Acute, localized autoinoculable infectious disease usually acquired through sexual contact. Caused by HAEMOPHILUS DUCREYI, it occurs endemically almost worldwide, especially in tropical and subtropical countries and more commonly in seaports and urban areas than in rural areas.
Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
The functional hereditary units of BACTERIA.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
A whiplike motility appendage present on the surface cells. Prokaryote flagella are composed of a protein called FLAGELLIN. Bacteria can have a single flagellum, a tuft at one pole, or multiple flagella covering the entire surface. In eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella have the same basic structure as CILIA but are longer in proportion to the cell bearing them and present in much smaller numbers. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Gram-negative helical bacteria, in the genus BORRELIA, that are the etiologic agents of LYME DISEASE. The group comprises many specific species including Borrelia afzelii, Borellia garinii, and BORRELIA BURGDORFERI proper. These spirochetes are generally transmitted by several species of ixodid ticks.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
Pathological processes involving the male reproductive tract (GENITALIA, MALE).
Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES.

Proteome composition and codon usage in spirochaetes: species-specific and DNA strand-specific mutational biases. (1/828)

The genomes of the spirochaetes Borrelia burgdorferi and Treponema pallidum show strong strand-specific skews in nucleotide composition, with the leading strand in replication being richer in G and T than the lagging strand in both species. This mutation bias results in codon usage and amino acid composition patterns that are significantly different between genes encoded on the two strands, in both species. There are also substantial differences between the species, with T.pallidum having a much higher G+C content than B. burgdorferi. These changes in amino acid and codon compositions represent neutral sequence change that has been caused by strong strand- and species-specific mutation pressures. Genes that have been relocated between the leading and lagging strands since B. burgdorferi and T.pallidum diverged from a common ancestor now show codon and amino acid compositions typical of their current locations. There is no evidence that translational selection operates on codon usage in highly expressed genes in these species, and the primary influence on codon usage is whether a gene is transcribed in the same direction as replication, or opposite to it. The dnaA gene in both species has codon usage patterns distinctive of a lagging strand gene, indicating that the origin of replication lies downstream of this gene, possibly within dnaN. Our findings strongly suggest that gene-finding algorithms that ignore variability within the genome may be flawed.  (+info)

Vertical transmission of Treponema pallidum to various litters and generations of guinea pigs. (2/828)

The transmission of congenital syphilis was studied in a 4-generation guinea pig family with 10 litters and 38 offspring. By use of one or all of the following tests (ELISA-IgM, polymerase chain reaction, and rabbit infectivity), transplacental infection was demonstrated through 5 litters and up to 4 generations. Twenty-eight (93%) of 30 animals were positive by >/=1 test, and 2 (7%) were negative by 1 or 3 tests. While transmission of the pathogen appeared to be unaffected by the maternal acquisition of immunity, signs of smoldering infection in the young was suggested by the decline in humoral responses in successive progeny and by unusual rabbit infectivity test results. With each pregnancy there was a remarkable booster in the maternal humoral response, which dropped significantly prior to term. These findings shed new light on the understanding and interpretation of serologic testing during pregnancy and the perinatal period.  (+info)

Membrane topology and cellular location of the Treponema pallidum glycerophosphodiester phosphodiesterase (GlpQ) ortholog. (3/828)

Recent reports that isolated Treponema pallidum outer membranes contain an ortholog for glycerophosphodiester phosphodiesterase (GlpQ) (D. V. Shevchenko, D. R. Akins, E. J. Robinson, M. Li, O. V. Shevchenko, and J. D. Radolf, Infect. Immun. 65:4179-4189, 1997) and that this protein is a potential opsonic target for T. pallidum (C. E. Stebeck, J. M. Shaffer, T. W. Arroll, S. A. Lukehart, and W. C. Van Voorhis, FEMS Microbiol. Lett. 154:303-310, 1997) prompted a more detailed investigation of its physicochemical properties and cellular location. [14C]palmitate radiolabeling studies of a GlpQ-alkaline phosphatase fusion expressed in Escherichia coli confirmed the prediction from DNA sequencing that the protein is lipid modified. Studies using Triton X-114 phase partitioning revealed that the protein's amphiphilicity is due to lipid modification and that a substantial portion of the polypeptide is associated with the T. pallidum peptidoglycan sacculus. Three different approaches, i.e., (i) proteinase K treatment of intact treponemes, (ii) indirect immunofluorescence analysis of treponemes encapsulated in agarose beads, and (iii) opsonophagocytosis of treponemes incubated with antiserum against recombinant GlpQ by rabbit peritoneal macrophages, confirmed that GlpQ is entirely subsurface in T. pallidum. Moreover, rabbits hyperimmunized with GlpQ were not protected against intradermal challenge with virulent treponemes. Circular dichroism spectroscopy confirmed that the recombinant form of the polypeptide lacked discernible evidence of denaturation. Finally, GlpQ was not radiolabeled when T. pallidum outer membranes were incubated with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)-diazarene, a photoactivatable, lipophilic probe which promiscuously labels both proteins and lipids within phospholipid bilayers. Taken as a whole, these studies indicate that the T. pallidum GlpQ ortholog is a periplasmic protein associated predominantly with the spirochete's peptidoglycan-cytoplasmic membrane complex.  (+info)

Sequence conservation of glycerophosphodiester phosphodiesterase among Treponema pallidum strains. (4/828)

Previous investigations have demonstrated that immunization with Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase significantly protects rabbits from subsequent treponeme challenge. In this report, we show that the glycerophosphodiester phosphodiesterase amino acid sequence is conserved among 12 strains from a total of five pathogenic treponemes. The invariant nature of this immunoprotective antigen makes it an attractive candidate for inclusion in a universal subunit vaccine against T. pallidum infection. In addition, these studies show a silent nucleotide substitution at position 579 of the gpd open reading frame which is consistently observed in the non-T. pallidum subsp. pallidum strains. This sequence alteration introduces a PleI restriction site in the nonsyphilis strains and thus allows genetic differentiation from T. pallidum subsp. pallidum strains.  (+info)

Correlation of immunity in experimental syphilis with serum-mediated aggregation of Treponema pallidum rare outer membrane proteins. (5/828)

We have previously shown by freeze-fracture electron microscopy that serum from infection-immune syphilitic rabbits aggregates the low-density membrane-spanning Treponema pallidum rare outer membrane proteins (TROMPs). The purpose of this study was to determine if a relationship could be demonstrated between acquired immunity in experimental rabbit syphilis, serum complement-dependent treponemicidal antibody, and antibody directed against TROMPs as measured by the aggregation of TROMP particles. Three groups of T. pallidum-infected rabbits were treated curatively with penicillin at 9 days, 30 days, and 6 months postinfection to generate various degrees of immunity to challenge reinfection. Sera from rabbits completely susceptible to localized and disseminated reinfection possessed a low titer of treponemicidal antibody (/=50% of a treponemal suspension) and showed a correspondingly low level of TROMP aggregation (16.5% of the total number of outer membrane particles counted) similar to normal serum controls (13. 4%); the number of particles within these aggregates never exceeded three. Sera from partially immune rabbits, which were susceptible to local reinfection but had no evidence of dissemination, showed an increase in the titer of treponemicidal antibody (1:16) compared to the completely susceptible group (+info)

Development of a system for expressing heterologous genes in the oral spirochete Treponema denticola and its use in expression of the Treponema pallidum flaA gene. (6/828)

The present communication describes the construction of a new Escherichia coli-Treponema denticola shuttle vector based on the naturally occurring spirochete plasmid pTS1 and the expression of the heterologous T. pallidum flaA gene from the plasmid in T. denticola. This new shuttle vector system should prove useful in characterizing virulence factors from unculturable pathogenic spirochetes.  (+info)

Physicochemical evidence that Treponema pallidum TroA is a zinc-containing metalloprotein that lacks porin-like structure. (7/828)

Although TroA (Tromp1) was initially reported to be a Treponema pallidum outer membrane protein with porin-like properties, subsequent studies have suggested that it actually is a periplasmic substrate-binding protein involved in the transport of metals across the treponemal cytoplasmic membrane. Here we conducted additional physicochemical studies to address the divergent viewpoints concerning this protein. Triton X-114 phase partitioning of recombinant TroA constructs with or without a signal sequence corroborated our prior contention that the native protein's amphiphilic behavior is due to its uncleaved leader peptide. Whereas typical porins are trimers with extensive beta-barrel structure, size exclusion chromatography and circular dichroism spectroscopy revealed that TroA was a monomer and predominantly alpha-helical. Neutron activation, atomic absorption spectroscopy, and anomalous X-ray scattering all demonstrated that TroA binds zinc in a 1:1 molar stoichiometric ratio. TroA does not appear to possess structural features consistent with those of bacterial porins.  (+info)

Demonstration by mass spectrometry that purified native Treponema pallidum rare outer membrane protein 1 (Tromp1) has a cleaved signal peptide. (8/828)

Purified native Tromp1 was subjected to mass spectrometric analysis in order to determine conclusively whether this protein possesses a cleaved or uncleaved signal peptide. The molecular masses of Tromp1, three Treponema pallidum lipoproteins, and a bovine serum albumin (BSA) control were determined by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. The molecular masses of all of the T. pallidum lipoproteins and BSA were within 0.7% of their respective calculated masses. The molecular mass of Tromp1 was 31,510 Da, which is consistent with a signal-less form of Tromp1, given a calculated mass of unprocessed Tromp1 of 33, 571 Da, a difference of 2,061 Da (a 6.5% difference). Purified native Tromp1 was also subjected to MALDI-TOF analysis in comparison to recombinant Tromp1 following cyanogen bromide cleavage, which further confirmed the identity of Tromp1 and showed that native Tromp1 was not degraded at the carboxy terminus. These studies confirm that Tromp1 is processed and does not contain an uncleaved signal peptide as previously reported.  (+info)

"Treponema pallidum" is a species of spiral-shaped bacteria (a spirochete) that is the causative agent of syphilis, a sexually transmitted infection. The bacterium is very thin and difficult to culture in the laboratory, which has made it challenging for researchers to study its biology and develop new treatments for syphilis.

The bacterium can infect various tissues and organs in the body, leading to a wide range of symptoms that can affect multiple systems, including the skin, bones, joints, cardiovascular system, and nervous system. The infection can be transmitted through sexual contact, from mother to fetus during pregnancy or childbirth, or through blood transfusions or shared needles.

Syphilis is a serious disease that can have long-term health consequences if left untreated. However, it is also curable with appropriate antibiotic therapy, such as penicillin. It is important to diagnose and treat syphilis early to prevent the spread of the infection and avoid potential complications.

Treponema is a genus of spiral-shaped bacteria, also known as spirochetes. These bacteria are gram-negative and have unique motility provided by endoflagella, which are located in the periplasmic space, running lengthwise between the cell's outer membrane and inner membrane.

Treponema species are responsible for several important diseases in humans, including syphilis (Treponema pallidum), yaws (Treponema pertenue), pinta (Treponema carateum), and endemic syphilis or bejel (Treponema pallidum subspecies endemicum). These diseases are collectively known as treponematoses.

It is important to note that while these bacteria share some common characteristics, they differ in their clinical manifestations and geographical distributions. Proper diagnosis and treatment of treponemal infections require medical expertise and laboratory confirmation.

Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum. It progresses in several stages if left untreated, with symptoms varying in each stage. The primary stage involves the appearance of a single, painless sore or multiple sores at the site where the bacteria entered the body, often on the genitals or around the mouth. During the secondary stage, individuals may experience rashes, fever, swollen lymph nodes, and other flu-like symptoms. In later stages, syphilis can lead to severe complications affecting the heart, brain, and other organs, known as tertiary syphilis. Neurosyphilis is a form of tertiary syphilis that affects the nervous system, causing various neurological problems. Congenital syphilis occurs when a pregnant woman with syphilis transmits the infection to her unborn child, which can result in serious birth defects and health issues for the infant. Early detection and appropriate antibiotic treatment can cure syphilis and prevent further complications.

Treponemal infections are a group of diseases caused by the spirochete bacterium Treponema pallidum. This includes syphilis, yaws, bejel, and pinta. These infections can affect various organ systems in the body and can have serious consequences if left untreated.

1. Syphilis: A sexually transmitted infection that can also be passed from mother to fetus during pregnancy or childbirth. It is characterized by sores (chancres) on the genitals, anus, or mouth, followed by a rash and flu-like symptoms. If left untreated, it can lead to serious complications such as damage to the heart, brain, and nervous system.
2. Yaws: A tropical infection that is spread through direct contact with infected skin lesions. It primarily affects children in rural areas of Africa, Asia, and South America. The initial symptom is a painless bump on the skin that eventually ulcerates and heals, leaving a scar. If left untreated, it can lead to disfigurement and destruction of bone and cartilage.
3. Bejel: Also known as endemic syphilis, this infection is spread through direct contact with infected saliva or mucous membranes. It primarily affects children in dry and arid regions of Africa, the Middle East, and Asia. The initial symptom is a painless sore on the mouth or skin, followed by a rash and other symptoms similar to syphilis.
4. Pinta: A tropical infection that is spread through direct contact with infected skin lesions. It primarily affects people in rural areas of Central and South America. The initial symptom is a red or brown spot on the skin, which eventually turns into a scaly rash. If left untreated, it can lead to disfigurement and destruction of pigmentation in the skin.

Treponemal infections can be diagnosed through blood tests that detect antibodies against Treponema pallidum. Treatment typically involves antibiotics such as penicillin, which can cure the infection if caught early enough. However, untreated treponemal infections can lead to serious health complications and even death.

The Treponema pallidum Immunity (TPI) test, also known as the Treponema immobilization test, is not a commonly used diagnostic tool in modern medicine. It was previously used as a serological test to detect antibodies against Treponema pallidum, the spirochete bacterium that causes syphilis.

In this test, a sample of the patient's serum is incubated with a suspension of live Treponema pallidum organisms. If the patient has antibodies against T. pallidum, these antibodies will bind to the organisms and immobilize them. The degree of immobilization is then observed and measured under a microscope.

However, this test has largely been replaced by more sensitive and specific serological tests such as the fluorescent treponemal antibody absorption (FTA-ABS) test and the Treponema pallidum particle agglutination (TPPA) assay. These tests are able to detect both IgG and IgM antibodies, providing information on both past and current infections. The TPI test, on the other hand, is less specific and may produce false-positive results in individuals who have been vaccinated against other treponemal diseases such as yaws or pinta.

Therefore, the Treponema Immobilization Test is not a widely used or recommended diagnostic tool for syphilis in current medical practice.

Syphilis serodiagnosis is a laboratory testing method used to diagnose syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. It involves detecting specific antibodies produced by the immune system in response to the infection, rather than directly detecting the bacteria itself.

There are two main types of serological tests used for syphilis serodiagnosis: treponemal and nontreponemal tests.

1. Treponemal tests: These tests detect antibodies that specifically target Treponema pallidum. Examples include the fluorescent treponemal antibody absorption (FTA-ABS) test, T. pallidum particle agglutination (TP-PA) assay, and enzyme immunoassays (EIAs) or chemiluminescence immunoassays (CIAs) for Treponema pallidum antibodies. These tests are highly specific but may remain reactive even after successful treatment, indicating past exposure or infection rather than a current active infection.

2. Nontreponemal tests: These tests detect antibodies produced against cardiolipin, a lipid found in the membranes of Treponema pallidum and other bacteria. Examples include the Venereal Disease Research Laboratory (VDRL) test and the Rapid Plasma Reagin (RPR) test. These tests are less specific than treponemal tests but can be used to monitor disease progression and treatment response, as their results often correlate with disease activity. Nontreponemal test titers usually decrease or become nonreactive after successful treatment.

Syphilis serodiagnosis typically involves a two-step process, starting with a nontreponemal test followed by a treponemal test for confirmation. This approach helps distinguish between current and past infections while minimizing false positives. It is essential to interpret serological test results in conjunction with the patient's clinical history, physical examination findings, and any additional diagnostic tests.

Yaws is a chronic, infectious disease caused by the spirochete bacterium Treponema pallidum pertenue. It primarily affects the skin, bones, and cartilage. The initial symptom is a small, hard bump (called a papule or mother yaw) that develops into an ulcer with a raised, red border and a yellow-crusted center. This lesion can be painful and pruritic (itchy). Yaws is usually contracted through direct contact with an infected person's lesion, typically during childhood. The disease is common in rural areas of tropical regions with poor sanitation and limited access to healthcare, particularly in West and Central Africa, the Pacific Islands, and parts of South America and Asia.

Yaws is treatable with antibiotics, such as penicillin, which can kill the bacteria and halt the progression of the disease. In most cases, a single injection of long-acting penicillin is sufficient to cure the infection. However, it's essential to identify and treat yaws early to prevent severe complications, including disfigurement and disability.

It's important to note that yaws should not be confused with other treponemal diseases, such as syphilis (caused by Treponema pallidum subspecies pallidum) or pinta (caused by Treponema carateum). While these conditions share some similarities in their clinical presentation and transmission, they are distinct diseases with different geographic distributions and treatment approaches.

Treponema denticola is a gram-negative, spiral-shaped bacterium that belongs to the genus Treponema. It is commonly found in the oral cavity and is associated with periodontal diseases such as chronic periodontitis. T. denticola is one of the "red complex" bacteria, which also includes Porphyromonas gingivalis and Tannerella forsythia, that are strongly associated with periodontal disease. These bacteria form a complex biofilm in the subgingival area and contribute to the breakdown of the periodontal tissues, leading to pocket formation, bone loss, and ultimately tooth loss if left untreated.

T. denticola has several virulence factors, including lipopolysaccharides (LPS), proteases, fimbriae, and endotoxins, that allow it to evade the host's immune system and cause tissue damage. It can also modulate the host's immune response, leading to a chronic inflammatory state that contributes to the progression of periodontal disease.

In addition to its role in periodontal disease, T. denticola has been linked to several systemic diseases, including cardiovascular disease, diabetes, and rheumatoid arthritis. However, more research is needed to fully understand the relationship between T. denticola and these conditions.

Congenital Syphilis is a medical condition that occurs when a mother with active syphilis infects her fetus through the placenta during pregnancy. If left untreated, congenital syphilis can lead to serious health problems in the newborn and can even cause death. The symptoms of congenital syphilis can appear at any time during the first two years of life, and they may include:

* Skin rashes or sores on the body, including the hands and feet
* Deformities of the bones and teeth
* Vision problems or blindness
* Hearing loss
* Developmental delays
* Neurological issues, such as seizures or difficulty coordinating movements
* Anemia
* Jaundice
* Enlarged liver and spleen

If congenital syphilis is diagnosed early, it can be treated with antibiotics, which can help to prevent serious health problems and reduce the risk of transmission to others. However, if left untreated, congenital syphilis can lead to long-term complications, such as developmental delays, neurological damage, and blindness. It is important for pregnant women to be screened for syphilis early in pregnancy and receive appropriate treatment to prevent the transmission of this serious infection to their unborn child.

A chancre is a medical term that refers to a hard, painless skin ulcer that is typically the first stage of certain bacterial infections, most commonly syphilis. It is usually round or oval in shape and can appear as a sore or lesion on the skin or mucous membranes, such as the genitals, anus, or mouth. The chancre is caused by the bacterium Treponema pallidum and is typically accompanied by swollen lymph nodes in the nearby area.

The chancre usually develops about 3 weeks after exposure to the bacteria and can last for several weeks. While it may heal on its own, it's important to seek medical attention if you suspect you have a chancre, as syphilis is a serious infection that can cause long-term health problems if left untreated. Treatment with antibiotics, such as penicillin, can cure syphilis and prevent further complications.

I believe there may be some confusion in your question. "Rabbits" is a common name used to refer to the Lagomorpha species, particularly members of the family Leporidae. They are small mammals known for their long ears, strong legs, and quick reproduction.

However, if you're referring to "rabbits" in a medical context, there is a term called "rabbit syndrome," which is a rare movement disorder characterized by repetitive, involuntary movements of the fingers, resembling those of a rabbit chewing. It is also known as "finger-chewing chorea." This condition is usually associated with certain medications, particularly antipsychotics, and typically resolves when the medication is stopped or adjusted.

Bacterial antibodies are a type of antibodies produced by the immune system in response to an infection caused by bacteria. These antibodies are proteins that recognize and bind to specific antigens on the surface of the bacterial cells, marking them for destruction by other immune cells. Bacterial antibodies can be classified into several types based on their structure and function, including IgG, IgM, IgA, and IgE. They play a crucial role in the body's defense against bacterial infections and provide immunity to future infections with the same bacteria.

Neurosyphilis is a term used to describe the invasion and infection of the nervous system by the spirochetal bacterium Treponema pallidum, which is the causative agent of syphilis. This serious complication can occur at any stage of syphilis, although it's more common in secondary or tertiary stages if left untreated. Neurosyphilis can cause a variety of neurological and psychiatric symptoms, such as:

1. Meningitis: Inflammation of the meninges (the protective membranes covering the brain and spinal cord) leading to headaches, stiff neck, and fever.
2. Meningovascular syphilis: Affects the blood vessels in the brain causing strokes, transient ischemic attacks (TIAs), or small-vessel disease, which can lead to cognitive decline.
3. General paresis (also known as tertiary general paresis): Progressive dementia characterized by memory loss, personality changes, disorientation, and psychiatric symptoms like delusions or hallucinations.
4. Tabes dorsalis: A degenerative disorder affecting the spinal cord, leading to ataxia (loss of coordination), muscle weakness, pain, sensory loss, and bladder and bowel dysfunction.
5. Argyll Robertson pupils: Small, irregularly shaped pupils that react poorly or not at all to light but constrict when focusing on near objects. This is a rare finding in neurosyphilis.

Diagnosis of neurosyphilis typically involves a combination of clinical evaluation, cerebrospinal fluid (CSF) analysis, and serological tests for syphilis. Treatment usually consists of intravenous penicillin G, which can halt the progression of the disease if initiated early enough. However, any neurological damage that has already occurred may be irreversible. Regular follow-up evaluations are essential to monitor treatment response and potential complications.

Cutaneous syphilis refers to the manifestation of the sexually transmitted infection syphilis on the skin. This can occur in various stages of the disease. In the primary stage, it may appear as a painless chancre (ulcer) at the site of infection, usually appearing 3 weeks after exposure. In the secondary stage, a widespread rash can develop, often affecting the palms and soles, along with other symptoms such as fever, swollen lymph nodes, and hair loss. Later stages of syphilis can also cause skin issues, including condylomata lata (broad, flat warts) and gummatous lesions (large, destructive ulcers). It's important to note that if left untreated, syphilis can lead to serious complications affecting the heart, brain, and other organs.

Bacterial antigens are substances found on the surface or produced by bacteria that can stimulate an immune response in a host organism. These antigens can be proteins, polysaccharides, teichoic acids, lipopolysaccharides, or other molecules that are recognized as foreign by the host's immune system.

When a bacterial antigen is encountered by the host's immune system, it triggers a series of responses aimed at eliminating the bacteria and preventing infection. The host's immune system recognizes the antigen as foreign through the use of specialized receptors called pattern recognition receptors (PRRs), which are found on various immune cells such as macrophages, dendritic cells, and neutrophils.

Once a bacterial antigen is recognized by the host's immune system, it can stimulate both the innate and adaptive immune responses. The innate immune response involves the activation of inflammatory pathways, the recruitment of immune cells to the site of infection, and the production of antimicrobial peptides.

The adaptive immune response, on the other hand, involves the activation of T cells and B cells, which are specific to the bacterial antigen. These cells can recognize and remember the antigen, allowing for a more rapid and effective response upon subsequent exposures.

Bacterial antigens are important in the development of vaccines, as they can be used to stimulate an immune response without causing disease. By identifying specific bacterial antigens that are associated with virulence or pathogenicity, researchers can develop vaccines that target these antigens and provide protection against infection.

Hemagglutination tests are laboratory procedures used to detect the presence of antibodies or antigens in a sample, typically in blood serum. These tests rely on the ability of certain substances, such as viruses or bacteria, to agglutinate (clump together) red blood cells.

In a hemagglutination test, a small amount of the patient's serum is mixed with a known quantity of red blood cells that have been treated with a specific antigen. If the patient has antibodies against that antigen in their serum, they will bind to the antigens on the red blood cells and cause them to agglutinate. This clumping can be observed visually, indicating a positive test result.

Hemagglutination tests are commonly used to diagnose infectious diseases caused by viruses or bacteria that have hemagglutinating properties, such as influenza, parainfluenza, and HIV. They can also be used in blood typing and cross-matching before transfusions.

The Fluorescent Treponemal Antibody-Absorption (FTA-ABS) test is a type of blood test used to diagnose syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. The FTA-ABS test is a treponemal test, which means it looks for antibodies that the body produces in response to an infection with T. pallidum.

The FTA-ABS test works by using a fluorescent dye to label treponemal antigens, which are substances that can trigger an immune response in people who have been infected with T. pallidum. The labeled antigens are then mixed with a sample of the patient's blood. If the patient has antibodies against T. pallidum, they will bind to the labeled antigens and form a complex.

To ensure that the test is specific for syphilis and not another type of treponemal infection, such as yaws or pinta, the sample is then absorbed with antigens from these other treponemal organisms. This step removes any antibodies that may cross-react with the non-syphilitic treponemes, leaving only those specific to T. pallidum.

The mixture is then washed and examined under a fluorescent microscope. If there are fluorescing particles present, it indicates that the patient has antibodies against T. pallidum, which suggests a current or past infection with syphilis.

It's important to note that the FTA-ABS test can remain positive for life, even after successful treatment of syphilis, so it cannot be used to determine if a patient has an active infection. Other tests, such as a venereal disease research laboratory (VDRL) or rapid plasma reagin (RPR) test, are used to detect non-treponemal antibodies that may indicate an active infection.

Spirochaetaceae is a family of spiral-shaped, gram-negative bacteria known as spirochetes. These bacteria are characterized by their unique morphology, which includes a flexible helical shape and the presence of endoflagella, which are located inside the cell wall and run lengthwise along the entire length of the organism. This arrangement of flagella allows the spirochete to move in a corkscrew-like motion.

Spirochaetaceae includes several genera of medically important bacteria, such as:

* Treponema: This genus includes the bacterium that causes syphilis (Treponema pallidum) and other treponemal diseases like yaws and pinta.
* Borrelia: This genus includes the spirochetes responsible for Lyme disease (Borrelia burgdorferi) and relapsing fever (Borrelia recurrentis).
* Leptospira: This genus contains the bacteria that cause leptospirosis, a zoonotic disease transmitted through the urine of infected animals.

Spirochetes are often found in aquatic environments and can be part of the normal microbiota of some animals, including humans. However, certain species can cause significant diseases in humans and animals, making them important pathogens. Proper identification and appropriate antibiotic treatment are crucial for managing spirochetal infections.

Penicillin G Benzathine is a type of antibiotic that is used to treat various bacterial infections. According to the International Journal of Antimicrobial Agents, Penicillin G Benzathine is a "water-soluble salt of penicillin G, which has a very high degree of stability and provides prolonged low-level serum concentrations after intramuscular injection."

It is often used to treat infections caused by streptococci and treponema pallidum, the bacterium that causes syphilis. Penicillin G Benzathine works by interfering with the ability of these bacteria to form a cell wall, which is essential for their survival. Without a functional cell wall, the bacteria are unable to grow and multiply, and are eventually destroyed by the body's immune system.

Penicillin G Benzathine is typically administered via intramuscular injection, and its prolonged release allows for less frequent dosing compared to other forms of penicillin. However, it may not be suitable for all patients, particularly those with a history of allergic reactions to penicillin or other antibiotics. As with any medication, Penicillin G Benzathine should only be used under the supervision of a healthcare provider.

"Spirochaeta" is a genus of spirochete bacteria, characterized by their long, spiral-shaped bodies. These bacteria are gram-negative, meaning they do not retain crystal violet dye in the Gram staining method, and are typically motile, moving by means of endoflagella located within their outer membrane. Members of this genus are found in various environments, including freshwater, marine, and terrestrial habitats. Some species are free-living, while others are parasitic or symbiotic with animals. It is important to note that the medical significance of "Spirochaeta" species is limited compared to other spirochete genera like "Treponema," which includes the bacterium causing syphilis.

Spirochaetales is an order of bacteria that are characterized by their unique spiral or corkscrew shape. This shape allows them to move in a flexing, twisting motion, which can be quite rapid. They are gram-negative, meaning they do not retain crystal violet stain in the Gram staining method, and they have a unique structure with endoflagella (also known as axial filaments) located inside their outer membrane.

The Spirochaetales order includes several families and genera of bacteria, some of which are free-living, while others are parasitic or symbiotic. The parasitic spirochetes can cause various diseases in humans and animals. For example, Treponema pallidum is the causative agent of syphilis, a serious sexually transmitted infection. Another species, Borrelia burgdorferi, causes Lyme disease, which is transmitted to humans through the bite of infected black-legged ticks.

It's important to note that spirochetes are a diverse group with varying characteristics and pathogenic potential. While some species can cause significant harm, others are not associated with diseases and play essential roles in various ecosystems.

Latent syphilis is a stage of the sexually transmitted infection (STI) syphilis, which is caused by the bacterium Treponema pallidum. In this stage, individuals who have been infected with syphilis do not show any symptoms of the disease. However, the bacteria remain in their body and can be passed on to others through sexual contact.

Latent syphilis is typically divided into two stages: early latent syphilis and late latent syphilis. Early latent syphilis is defined as occurring within the first year of infection, while late latent syphilis occurs more than a year after the initial infection. During the early latent stage, individuals may still have a positive blood test for syphilis and can still transmit the disease to others through sexual contact. In contrast, during the late latent stage, the risk of transmitting the disease is much lower, but it is still possible.

It's important to note that if left untreated, latent syphilis can progress to more serious stages of the disease, including tertiary syphilis, which can cause severe damage to the heart, brain, and other organs. Therefore, it's essential for individuals who have been diagnosed with latent syphilis to receive appropriate treatment and follow-up care from a healthcare provider.

Bacterial proteins are a type of protein that are produced by bacteria as part of their structural or functional components. These proteins can be involved in various cellular processes, such as metabolism, DNA replication, transcription, and translation. They can also play a role in bacterial pathogenesis, helping the bacteria to evade the host's immune system, acquire nutrients, and multiply within the host.

Bacterial proteins can be classified into different categories based on their function, such as:

1. Enzymes: Proteins that catalyze chemical reactions in the bacterial cell.
2. Structural proteins: Proteins that provide structural support and maintain the shape of the bacterial cell.
3. Signaling proteins: Proteins that help bacteria to communicate with each other and coordinate their behavior.
4. Transport proteins: Proteins that facilitate the movement of molecules across the bacterial cell membrane.
5. Toxins: Proteins that are produced by pathogenic bacteria to damage host cells and promote infection.
6. Surface proteins: Proteins that are located on the surface of the bacterial cell and interact with the environment or host cells.

Understanding the structure and function of bacterial proteins is important for developing new antibiotics, vaccines, and other therapeutic strategies to combat bacterial infections.

Genitalia, also known as the genitals, refer to the reproductive organs located in the pelvic region. In males, these include the penis and testicles, while in females, they consist of the vulva, vagina, clitoris, and ovaries. Genitalia are essential for sexual reproduction and can also be associated with various medical conditions, such as infections, injuries, or congenital abnormalities.

A medical definition of an ulcer is:

A lesion on the skin or mucous membrane characterized by disintegration of surface epithelium, inflammation, and is associated with the loss of substance below the normal lining. Gastric ulcers and duodenal ulcers are types of peptic ulcers that occur in the gastrointestinal tract.

Another type of ulcer is a venous ulcer, which occurs when there is reduced blood flow from vein insufficiency, usually in the lower leg. This can cause skin damage and lead to an open sore or ulcer.

There are other types of ulcers as well, including decubitus ulcers (also known as pressure sores or bedsores), which are caused by prolonged pressure on the skin.

Dysentery is a medical condition characterized by inflammation of the intestine, particularly the colon, leading to severe diarrhea containing blood, mucus, and/or pus. It is typically caused by infectious agents such as bacteria (like Shigella, Salmonella, or Escherichia coli) or parasites (such as Entamoeba histolytica). The infection can be acquired through contaminated food, water, or direct contact with an infected person. Symptoms may also include abdominal cramps, fever, and dehydration. Immediate medical attention is required for proper diagnosis and treatment to prevent potential complications.

Necrotizing ulcerative gingivitis (NUG), also known as trench mouth or acute necrotizing ulcerative gingivostomatitis, is a severe and painful form of gingivitis that is characterized by the presence of necrosis (tissue death) and ulcers in the gum tissue. It is caused by a combination of factors, including poor oral hygiene, stress, smoking, and a weakened immune system. The condition is often associated with the presence of certain types of bacteria that produce toxins that can damage the gum tissue.

NUG is characterized by the sudden onset of symptoms such as severe pain, bleeding, bad breath, and a grayish-white or yellowish film covering the gums. The gums may also appear bright red, swollen, and shiny, and may bleed easily when brushed or touched. In some cases, the condition can progress to involve other areas of the mouth, such as the lining of the cheeks and lips.

NUG is typically treated with a combination of professional dental cleaning, antibiotics to eliminate the bacterial infection, and pain management. It is important to maintain good oral hygiene practices to prevent recurrence of the condition. If left untreated, NUG can lead to more serious complications such as tooth loss or spread of the infection to other parts of the body.

"Reagin" is an outdated term that was used to describe a type of antibody found in the blood serum of some individuals, particularly those who have had certain infectious diseases or who have allergies. These antibodies were known as "reaginic antibodies" and were characterized by their ability to cause a positive reaction in a test called the "Reagin test" or "Wassermann test."

The Reagin test was developed in the early 20th century and was used as a diagnostic tool for syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. The test involved mixing a patient's serum with a suspension of cardiolipin, lecithin, and cholesterol - components derived from heart tissue. If reaginic antibodies were present in the patient's serum, they would bind to the cardiolipin component and form a complex that could be detected through a series of chemical reactions.

However, it was later discovered that reaginic antibodies were not specific to syphilis and could be found in individuals with other infectious diseases or allergies. As a result, the term "reagin" fell out of favor, and the test is no longer used as a diagnostic tool for syphilis. Instead, more specific and accurate tests, such as the Venereal Disease Research Laboratory (VDRL) test and the Treponema pallidum particle agglutination (TP-PA) assay, are now used to diagnose syphilis.

Bacterial outer membrane proteins (OMPs) are a type of protein found in the outer membrane of gram-negative bacteria. The outer membrane is a unique characteristic of gram-negative bacteria, and it serves as a barrier that helps protect the bacterium from hostile environments. OMPs play a crucial role in maintaining the structural integrity and selective permeability of the outer membrane. They are involved in various functions such as nutrient uptake, transport, adhesion, and virulence factor secretion.

OMPs are typically composed of beta-barrel structures that span the bacterial outer membrane. These proteins can be classified into several groups based on their size, function, and structure. Some of the well-known OMP families include porins, autotransporters, and two-partner secretion systems.

Porins are the most abundant type of OMPs and form water-filled channels that allow the passive diffusion of small molecules, ions, and nutrients across the outer membrane. Autotransporters are a diverse group of OMPs that play a role in bacterial pathogenesis by secreting virulence factors or acting as adhesins. Two-partner secretion systems involve the cooperation between two proteins to transport effector molecules across the outer membrane.

Understanding the structure and function of bacterial OMPs is essential for developing new antibiotics and therapies that target gram-negative bacteria, which are often resistant to conventional treatments.

Bacterial DNA refers to the genetic material found in bacteria. It is composed of a double-stranded helix containing four nucleotide bases - adenine (A), thymine (T), guanine (G), and cytosine (C) - that are linked together by phosphodiester bonds. The sequence of these bases in the DNA molecule carries the genetic information necessary for the growth, development, and reproduction of bacteria.

Bacterial DNA is circular in most bacterial species, although some have linear chromosomes. In addition to the main chromosome, many bacteria also contain small circular pieces of DNA called plasmids that can carry additional genes and provide resistance to antibiotics or other environmental stressors.

Unlike eukaryotic cells, which have their DNA enclosed within a nucleus, bacterial DNA is present in the cytoplasm of the cell, where it is in direct contact with the cell's metabolic machinery. This allows for rapid gene expression and regulation in response to changing environmental conditions.

The testis, also known as the testicle, is a male reproductive organ that is part of the endocrine system. It is located in the scrotum, outside of the abdominal cavity. The main function of the testis is to produce sperm and testosterone, the primary male sex hormone.

The testis is composed of many tiny tubules called seminiferous tubules, where sperm are produced. These tubules are surrounded by a network of blood vessels, nerves, and supportive tissues. The sperm then travel through a series of ducts to the epididymis, where they mature and become capable of fertilization.

Testosterone is produced in the Leydig cells, which are located in the interstitial tissue between the seminiferous tubules. Testosterone plays a crucial role in the development and maintenance of male secondary sexual characteristics, such as facial hair, deep voice, and muscle mass. It also supports sperm production and sexual function.

Abnormalities in testicular function can lead to infertility, hormonal imbalances, and other health problems. Regular self-examinations and medical check-ups are recommended for early detection and treatment of any potential issues.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

Lipoproteins are complex particles composed of multiple proteins and lipids (fats) that play a crucial role in the transport and metabolism of fat molecules in the body. They consist of an outer shell of phospholipids, free cholesterols, and apolipoproteins, enclosing a core of triglycerides and cholesteryl esters.

There are several types of lipoproteins, including:

1. Chylomicrons: These are the largest lipoproteins and are responsible for transporting dietary lipids from the intestines to other parts of the body.
2. Very-low-density lipoproteins (VLDL): Produced by the liver, VLDL particles carry triglycerides to peripheral tissues for energy storage or use.
3. Low-density lipoproteins (LDL): Often referred to as "bad cholesterol," LDL particles transport cholesterol from the liver to cells throughout the body. High levels of LDL in the blood can lead to plaque buildup in artery walls and increase the risk of heart disease.
4. High-density lipoproteins (HDL): Known as "good cholesterol," HDL particles help remove excess cholesterol from cells and transport it back to the liver for excretion or recycling. Higher levels of HDL are associated with a lower risk of heart disease.

Understanding lipoproteins and their roles in the body is essential for assessing cardiovascular health and managing risks related to heart disease and stroke.

Bacteriological techniques refer to the various methods and procedures used in the laboratory for the cultivation, identification, and study of bacteria. These techniques are essential in fields such as medicine, biotechnology, and research. Here are some common bacteriological techniques:

1. **Sterilization**: This is a process that eliminates or kills all forms of life, including bacteria, viruses, fungi, and spores. Common sterilization methods include autoclaving (using steam under pressure), dry heat (in an oven), chemical sterilants, and radiation.

2. **Aseptic Technique**: This refers to practices used to prevent contamination of sterile materials or environments with microorganisms. It includes the use of sterile equipment, gloves, and lab coats, as well as techniques such as flaming, alcohol swabbing, and using aseptic transfer devices.

3. **Media Preparation**: This involves the preparation of nutrient-rich substances that support bacterial growth. There are various types of media, including solid (agar), liquid (broth), and semi-solid (e.g., stab agar). The choice of medium depends on the type of bacteria being cultured and the purpose of the investigation.

4. **Inoculation**: This is the process of introducing a bacterial culture into a medium. It can be done using a loop, swab, or needle. The inoculum should be taken from a pure culture to avoid contamination.

5. **Incubation**: After inoculation, the bacteria are allowed to grow under controlled conditions of temperature, humidity, and atmospheric composition. This process is called incubation.

6. **Staining and Microscopy**: Bacteria are too small to be seen with the naked eye. Therefore, they need to be stained and observed under a microscope. Gram staining is a common method used to differentiate between two major groups of bacteria based on their cell wall composition.

7. **Biochemical Tests**: These are tests used to identify specific bacterial species based on their biochemical characteristics, such as their ability to ferment certain sugars, produce particular enzymes, or resist certain antibiotics.

8. **Molecular Techniques**: Advanced techniques like PCR and DNA sequencing can provide more precise identification of bacteria. They can also be used for genetic analysis and epidemiological studies.

Remember, handling microorganisms requires careful attention to biosafety procedures to prevent accidental infection or environmental contamination.

Orchitis is a medical condition characterized by inflammation of one or both testicles, usually caused by an infection. The most common cause of orchitis is a bacterial infection that spreads from the epididymis, resulting in a condition known as epididymo-orchitis. However, viral infections such as mumps can also lead to orchitis. Symptoms may include sudden and severe pain in the testicle(s), swelling, warmth, redness of the overlying skin, nausea, vomiting, and fever. Treatment typically involves antibiotics for bacterial infections and supportive care for symptom relief. If left untreated, orchitis can lead to complications such as infertility or testicular atrophy.

Chancroid is a sexually transmitted infection caused by the bacterium Haemophilus ducreyi. It is characterized by the presence of painful, ulcerating lesions on the genitals. The infection is more common in men than women and is often found in areas with poor sanitation and hygiene. Chancroid is a major cause of genital ulcers in many parts of the world, but it is relatively rare in developed countries.

The primary symptom of chancroid is the development of one or more painful, soft, and easily bleeding ulcers on the genitals within a few days to two weeks after exposure. The ulcers may be accompanied by swelling of the lymph nodes in the groin. In some cases, the ulcers may become covered with a gray or yellowish-white exudate.

Chancroid is diagnosed through the examination of a sample taken from the ulcer. The sample is examined under a microscope for the presence of H. ducreyi bacteria. If the bacteria are not visible, a culture can be grown to confirm the diagnosis.

Treatment for chancroid typically involves the use of antibiotics such as azithromycin or ceftriaxone. It is important to receive treatment promptly to prevent the spread of the infection and to avoid complications such as scarring, difficulty urinating, and infertility.

Prevention measures for chancroid include practicing safe sex, limiting the number of sexual partners, and getting regular STI screenings. If you suspect that you may have chancroid or any other STI, it is important to seek medical attention promptly.

Cardiolipins are a type of phospholipid that are primarily found in the inner mitochondrial membrane of cells. They play a crucial role in several important cellular processes, including energy production, apoptosis (programmed cell death), and maintenance of the structural integrity of the mitochondria.

Cardiolipins are unique because they contain four fatty acid chains, whereas most other phospholipids contain only two. This gives cardiolipins a distinctive conical shape that is important for their function in maintaining the curvature and stability of the inner mitochondrial membrane.

Cardiolipins have also been implicated in various diseases, including neurodegenerative disorders, cancer, and bacterial infections. For example, changes in cardiolipin composition or distribution have been linked to mitochondrial dysfunction in Parkinson's disease and other neurological conditions. Additionally, certain bacteria, such as Neisseria gonorrhoeae and Chlamydia trachomatis, can manipulate host cell cardiolipins to facilitate their own survival and replication.

In summary, cardiolipins are essential phospholipids found in the inner mitochondrial membrane that play a critical role in several cellular processes, and have been implicated in various diseases.

'Immune sera' refers to the serum fraction of blood that contains antibodies produced in response to an antigenic stimulus, such as a vaccine or an infection. These antibodies are proteins known as immunoglobulins, which are secreted by B cells (a type of white blood cell) and can recognize and bind to specific antigens. Immune sera can be collected from an immunized individual and used as a source of passive immunity to protect against infection or disease. It is often used in research and diagnostic settings to identify or measure the presence of specific antigens or antibodies.

A bacterial gene is a segment of DNA (or RNA in some viruses) that contains the genetic information necessary for the synthesis of a functional bacterial protein or RNA molecule. These genes are responsible for encoding various characteristics and functions of bacteria such as metabolism, reproduction, and resistance to antibiotics. They can be transmitted between bacteria through horizontal gene transfer mechanisms like conjugation, transformation, and transduction. Bacterial genes are often organized into operons, which are clusters of genes that are transcribed together as a single mRNA molecule.

It's important to note that the term "bacterial gene" is used to describe genetic elements found in bacteria, but not all genetic elements in bacteria are considered genes. For example, some DNA sequences may not encode functional products and are therefore not considered genes. Additionally, some bacterial genes may be plasmid-borne or phage-borne, rather than being located on the bacterial chromosome.

The Fluorescent Antibody Technique (FAT) is a type of immunofluorescence assay used in laboratory medicine and pathology for the detection and localization of specific antigens or antibodies in tissues, cells, or microorganisms. In this technique, a fluorescein-labeled antibody is used to selectively bind to the target antigen or antibody, forming an immune complex. When excited by light of a specific wavelength, the fluorescein label emits light at a longer wavelength, typically visualized as green fluorescence under a fluorescence microscope.

The FAT is widely used in diagnostic microbiology for the identification and characterization of various bacteria, viruses, fungi, and parasites. It has also been applied in the diagnosis of autoimmune diseases and certain cancers by detecting specific antibodies or antigens in patient samples. The main advantage of FAT is its high sensitivity and specificity, allowing for accurate detection and differentiation of various pathogens and disease markers. However, it requires specialized equipment and trained personnel to perform and interpret the results.

Flagella are long, thin, whip-like structures that some types of cells use to move themselves around. They are made up of a protein called tubulin and are surrounded by a membrane. In bacteria, flagella rotate like a propeller to push the cell through its environment. In eukaryotic cells (cells with a true nucleus), such as sperm cells or certain types of algae, flagella move in a wave-like motion to achieve locomotion. The ability to produce flagella is called flagellation.

Immunoglobulin M (IgM) is a type of antibody that is primarily found in the blood and lymph fluid. It is the first antibody to be produced in response to an initial exposure to an antigen, making it an important part of the body's primary immune response. IgM antibodies are large molecules that are composed of five basic units, giving them a pentameric structure. They are primarily found on the surface of B cells as membrane-bound immunoglobulins (mlgM), where they function as receptors for antigens. Once an mlgM receptor binds to an antigen, it triggers the activation and differentiation of the B cell into a plasma cell that produces and secretes large amounts of soluble IgM antibodies.

IgM antibodies are particularly effective at agglutination (clumping) and complement activation, which makes them important in the early stages of an immune response to help clear pathogens from the bloodstream. However, they are not as stable or long-lived as other types of antibodies, such as IgG, and their levels tend to decline after the initial immune response has occurred.

In summary, Immunoglobulin M (IgM) is a type of antibody that plays a crucial role in the primary immune response to antigens by agglutination and complement activation. It is primarily found in the blood and lymph fluid, and it is produced by B cells after they are activated by an antigen.

The Borrelia burgdorferi group, also known as the Borrelia burgdorferi sensu lato (s.l.) complex, refers to a genetically related group of spirochetal bacteria that cause Lyme disease and other related diseases worldwide. The group includes several species, with Borrelia burgdorferi sensu stricto (s.s.), B. afzelii, and B. garinii being the most common and best studied. These bacteria are transmitted to humans through the bite of infected black-legged ticks (Ixodes scapularis in the United States and Ixodes pacificus on the West Coast; Ixodes ricinus in Europe).

Lyme disease is a multisystem disorder that can affect the skin, joints, nervous system, and heart. Early symptoms typically include a characteristic expanding rash called erythema migrans, fever, fatigue, headache, and muscle and joint pain. If left untreated, the infection can spread to other parts of the body and cause more severe complications, such as arthritis, neurological problems, and carditis.

Diagnosis of Lyme disease is based on a combination of clinical symptoms, exposure history, and laboratory tests. Treatment usually involves antibiotics, such as doxycycline, amoxicillin, or ceftriaxone, and is generally most effective when initiated early in the course of the illness. Preventive measures, such as using insect repellent, checking for ticks after being outdoors, and promptly removing attached ticks, can help reduce the risk of Lyme disease and other tick-borne infections.

Surface antigens are molecules found on the surface of cells that can be recognized by the immune system as being foreign or different from the host's own cells. Antigens are typically proteins or polysaccharides that are capable of stimulating an immune response, leading to the production of antibodies and activation of immune cells such as T-cells.

Surface antigens are important in the context of infectious diseases because they allow the immune system to identify and target infected cells for destruction. For example, viruses and bacteria often display surface antigens that are distinct from those found on host cells, allowing the immune system to recognize and attack them. In some cases, these surface antigens can also be used as targets for vaccines or other immunotherapies.

In addition to their role in infectious diseases, surface antigens are also important in the context of cancer. Tumor cells often display abnormal surface antigens that differ from those found on normal cells, allowing the immune system to potentially recognize and attack them. However, tumors can also develop mechanisms to evade the immune system, making it difficult to mount an effective response.

Overall, understanding the properties and behavior of surface antigens is crucial for developing effective immunotherapies and vaccines against infectious diseases and cancer.

Penicillin G is a type of antibiotic that belongs to the class of medications called penicillins. It is a natural antibiotic derived from the Penicillium fungus and is commonly used to treat a variety of bacterial infections. Penicillin G is active against many gram-positive bacteria, as well as some gram-negative bacteria.

Penicillin G is available in various forms, including an injectable solution and a powder for reconstitution into a solution. It works by interfering with the ability of bacteria to form a cell wall, which ultimately leads to bacterial death. Penicillin G is often used to treat serious infections that cannot be treated with other antibiotics, such as endocarditis (inflammation of the inner lining of the heart), pneumonia, and meningitis (inflammation of the membranes surrounding the brain and spinal cord).

It's important to note that Penicillin G is not commonly used for topical or oral treatment due to its poor absorption in the gastrointestinal tract and instability in acidic environments. Additionally, as with all antibiotics, Penicillin G should be used under the guidance of a healthcare professional to ensure appropriate use and to reduce the risk of antibiotic resistance.

Genital diseases in males refer to various medical conditions that affect the male reproductive and urinary systems, including the penis, testicles, epididymis, vas deferens, seminal vesicles, prostate, and urethra. These conditions can be infectious, inflammatory, degenerative, or neoplastic (cancerous) in nature. Some common examples of male genital diseases include:

1. Balanitis: Inflammation of the foreskin and glans penis, often caused by infection, irritants, or poor hygiene.
2. Prostatitis: Inflammation of the prostate gland, which can be acute or chronic, bacterial or non-bacterial in origin.
3. Epididymitis: Inflammation of the epididymis, a coiled tube at the back of the testicle that stores and carries sperm. It is often caused by infection.
4. Orchitis: Inflammation of the testicle, usually resulting from infection or autoimmune disorders.
5. Testicular torsion: A surgical emergency characterized by twisting of the spermatic cord, leading to reduced blood flow and potential tissue damage in the testicle.
6. Varicocele: Dilated veins in the scrotum that can cause pain, discomfort, or fertility issues.
7. Peyronie's disease: A connective tissue disorder causing scarring and curvature of the penis during erections.
8. Penile cancer: Malignant growths on the penis, often squamous cell carcinomas, which can spread to other parts of the body if left untreated.
9. Benign prostatic hyperplasia (BPH): Non-cancerous enlargement of the prostate gland that can cause lower urinary tract symptoms such as difficulty initiating or maintaining a steady stream of urine.
10. Sexually transmitted infections (STIs): Infectious diseases, like chlamydia, gonorrhea, syphilis, and human papillomavirus (HPV), that can be transmitted through sexual contact and affect the male genital region.

Porins are a type of protein found in the outer membrane of gram-negative bacteria. They form water-filled channels, or pores, that allow small molecules such as ions, nutrients, and waste products to pass through the otherwise impermeable outer membrane. Porins are important for the survival of gram-negative bacteria, as they enable the selective transport of essential molecules while providing a barrier against harmful substances.

There are different types of porins, classified based on their structure and function. Some examples include:

1. General porins (also known as nonspecific porins): These are the most common type of porins and form large, water-filled channels that allow passive diffusion of small molecules up to 600-700 Da in size. They typically have a trimeric structure, with three identical or similar subunits forming a pore in the membrane.
2. Specific porins: These porins are more selective in the molecules they allow to pass through and often have smaller pores than general porins. They can be involved in the active transport of specific molecules or ions, requiring energy from the cell.
3. Autotransporters: While not strictly considered porins, autotransporter proteins share some structural similarities with porins and are involved in the transport of protein domains across the outer membrane. They consist of an N-terminal passenger domain and a C-terminal translocator domain, which forms a β-barrel pore in the outer membrane through which the passenger domain is transported.

Porins have attracted interest as potential targets for antibiotic development, as they play crucial roles in bacterial survival and virulence. Inhibiting porin function or blocking the pores could disrupt essential processes in gram-negative bacteria, providing a new approach to treating infections caused by these organisms.

Three subspecies of T. pallidum are known: Treponema pallidum pallidum, which causes syphilis T. p. endemicum, which causes ... Treponema pallidum pallidum is a motile spirochaete that is generally acquired by close sexual contact, entering the host via ... Treponema pallidum, formerly known as Spirochaeta pallida, is a spirochaete bacterium with various subspecies that cause the ... "Whole genome sequence of the Treponema pallidum subsp. pallidum strain Amoy: An Asian isolate highly similar to SS14". PLOS ONE ...
Treponema pallidum subspecies pallidum. It also detects other treponematoses.[citation needed] In the test, gelatin particles ... Treponema pallidum subspecies pallidum.[citation needed] In the test, red blood cells (erythrocytes) are sensitized with ... The Treponema pallidum particle agglutination assay (also called TPPA test) is an indirect agglutination assay used for ... An evaluation of the relative sensitivities of the venereal disease research laboratory test and the Treponema Pallidum ...
Syphilis (Treponema pallidum). Bennett J, Dolin R, Blaser M, eds. Mandell, Douglas, and Bennett's Principles and Practice of ... The CSF is tested for antibodies for specific Treponema pallidum antigens. The preferred test is the VDRL test, which is ... Within days to weeks after initial infection, Treponema pallidum disseminates via blood and lymphatics. The organism may ... pallidum with human immunodeficiency virus (HIV) has been found to affect the course of syphilis. Syphilis can lie dormant for ...
Treponema pallidum pallidum), yaws (Treponema pallidum pertenue), bejel (Treponema pallidum endemicum), and pinta (Treponema ... All other Treponema pallidum subspecies probably evolved from Treponema pallidum pertenue. Yaws is believed to have originated ... The genetic analysis of the yaws causative bacteria-Treponema pallidum pertenue-has led to the conclusion that yaws is the most ... Yaws is a tropical infection of the skin, bones, and joints caused by the spirochete bacterium Treponema pallidum pertenue. The ...
Klingmüller, G (December 1983). "[Treponema pallidum or Spirochaeta pallida?]". Der Hautarzt; Zeitschrift für Dermatologie, ... Spirochaeta pallida (also known as Treponema pallidum). The work was carried out at the Berlin Charité. Among Schaudinn's other ... Kohl, P K; Winzer I (February 2005). "[The 100 years since discovery of Spirochaeta pallida]". Der Hautarzt; Zeitschrift für ... Spier, H W (December 1972). "[In memoriam Fritz Schaudinn (1871-1906): discoverer of Spirochaeta pallida]". Der Hautarzt; ...
Fantry, Lori E.; Tramont, Edmund C. "Treponema Pallidum (Syphilis)". Archived from the original on 2015-03-12. Retrieved 2015- ...
... (/ˈsɪfəlɪs/) is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The ... Treponema pallidum subspecies pallidum is a spiral-shaped, Gram-negative, highly mobile bacterium. Three other human diseases ... "Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains: Most of the genetic differences are ... The causative organism, Treponema pallidum, was first identified by Fritz Schaudinn and Erich Hoffmann, in 1905. The first ...
Treponema pallidum, and Neisseria gonorrhoeae. Anaerobic bacteria have been implicated in tonsillitis, and a possible role in ... Sometimes tonsillitis is caused by an infection of spirochaeta and treponema, which is called Vincent's angina or Plaut-Vincent ...
"The binary protein interactome of Treponema pallidum--the syphilis spirochete". PLOS ONE. 3 (5): e2292. Bibcode:2008PLoSO... ... "Genome scale identification of Treponema pallidum antigens". Infection and Immunity. 73 (7): 4445-4450. doi:10.1128/IAI.73.7. ...
Treponema pallidum is a complicated bacterium to grow; it is propagated by passage in rabbits and it has a very fragile surface ... Lukehart identified that there was variation in the surface antigen of Treponema pallidum that could explain how it evades ... Her doctoral research introduced her to Treponema pallidum and syphilis, which would fascinate her throughout her career. She ... She studied the development of macrolide resistance in strains of Treponema pallidum, and showed that the bacterium frequently ...
Treponema pallidum troR, a metal-dependent transcriptional repressor. Archaeoglobus fulgidus MDR1 (troR), a metal-dependent ...
Syphilis: bacterial TORCH infection due to Treponema pallidum. Congenital syphilis can present with saber shins, saddle-shaped ...
1999). "Identification of Treponema pallidum Subspecies pallidum in a 200-Year-Old Skeletal Specimen." Journal of Infectious ... "Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains: Most of the genetic differences are ... The causative organism, Treponema pallidum, was first identified by Fritz Schaudinn and Erich Hoffmann in 1905 at the Charité ... In 2012, Rafael Montiel and his co-authors were successful in amplifying two Treponema pallidum DNA sequences dated to the ...
TIGR sequenced the genome of Treponema pallidum (which causes syphilis). In 1999 TIGR published the sequence of the ... "Complete genome sequence of Treponema pallidum, the syphilis spirochete". Science. 281 (5375): 375-388. Bibcode:1998Sci...281.. ...
... a spiral-shaped spirochete called Treponema pallidum, which they first called Spirochaeta pallida. The organism was removed ... Souza, Elemir Macedo de (October 2005). "A hundred years ago, the discovery of Treponema pallidum". Anais Brasileiros de ... Kohl, P. K.; Winzer, I. (February 2005). "[The 100 years since discovery of Spirochaeta pallida]". Der Hautarzt; Zeitschrift ...
1998). "Complete genome sequence of Treponema pallidum, the syphilis spirochete". Science. 281 (5375): 375-388. Bibcode:1998Sci ...
1998). "Complete genome sequence of Treponema pallidum, the syphilis spirochete". Science. 281 (5375): 375-88. Bibcode:1998Sci ... 2004). "Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes". Proc. Natl. Acad. Sci ...
In 1905 the cause of syphilis (Treponema pallidum) was identified. In the following year the Wassermann test for identification ...
"The binary protein interactome of Treponema pallidum--the syphilis spirochete". PLOS ONE. 3 (5): e2292. Bibcode:2008PLoSO... ...
"The Binary Protein Interactome of Treponema pallidum - the Syphilis Spirochete". PLOS ONE. 3 (5): e2292. Bibcode:2008PLoSO... ...
"The binary protein interactome of Treponema pallidum--the syphilis spirochete". PLOS ONE. 3 (5): e2292. Bibcode:2008PLoSO... ...
Treponema pallidum, the cause of syphilis, is spread by sexual activity. Viruses are obligate intracellular parasites, ...
Treponema pallidum. Treponema pallidum are various spiral shaped motile bacteria of the family spirochaetaceae. Their genus ... Treponema pallidum is the main cause of the onset of meningeal syphilis and other treponemal diseases, and it consists of a ... Treponema pallidum, a spirochate bacterium, is the main cause of syphilis, which spreads drastically throughout the body and ... Treponema pallidum invades the nervous system within three to eighteen months after the primary infection. The initial series ...
Noguchi's most famous contribution is his identification of the causative agent of syphilis (the bacteria Treponema pallidum) ... In 1913, Noguchi demonstrated the presence of Treponema pallidum (syphilitic spirochete) in the brain of a progressive ... Treponema pallidum)". JAMA. 58 (16): 1163-1172. doi:10.1001/jama.1912.04260040179001. Lederer SE. "Hideyo Noguchi's Luetin ... Med., 62.1 (1989), pp.1-9 Noguchi H (1912). "Experimental research in syphilis with especial reference to Spirochaeta pallida ( ...
Nelson and Mayer also developed Nelson-Mayer basal medium for growing Treponema pallidum bacteria in vitro. He and his wife ... subscription required) Nelson, Robert A.; Mayer, Manfred M. (1949). "Immobilization of Treponema pallidum in vitro by antibody ...
It is caused by Treponema pallidum and is a sexually transmitted infection. Many conditions can cause glossitis via ...
Bayly, H. W. (1910). "Demonstration by the Ultra-microscope of living Treponema pallidum and various Spirochaetes". Proceedings ... Syphilis spirochaeta pallida by Jean Comandon 1939 - Normal and abnormal white blood cells in tissue cultures by Warren Lewis ...
... of Treponema pallidum subsp. pallidum". Journal of Bacteriology. 178 (11): 3177-87. doi:10.1128/jb.178.11.3177-3187.1996. PMC ... "Cryo-electron tomography elucidates the molecular architecture of Treponema pallidum, the syphilis spirochete". Journal of ... Izard J, Sasaki H, Kent R (2012). "Pathogenicity of Treponema denticola Wild-Type and Mutant Strain Tested by an Active Mode of ... Murphy GE, Matson EG, Leadbetter JR, Berg HC, Jensen GJ (March 2008). "Novel ultrastructures of Treponema primitia and their ...
The band is named after treponema pallidum, the bacterium that causes syphilis. The band's music was described as a mixture of ...
Anorectal syphilis is caused by Treponema pallidum and is contracted through anoreceptive intercourse. Symptoms are usually ...
Three subspecies of T. pallidum are known: Treponema pallidum pallidum, which causes syphilis T. p. endemicum, which causes ... Treponema pallidum pallidum is a motile spirochaete that is generally acquired by close sexual contact, entering the host via ... Treponema pallidum, formerly known as Spirochaeta pallida, is a spirochaete bacterium with various subspecies that cause the ... "Whole genome sequence of the Treponema pallidum subsp. pallidum strain Amoy: An Asian isolate highly similar to SS14". PLOS ONE ...
This website provides an overview of the business activities and products of EUROIMMUN AG worldwide. Not all products are registered and approved in all countries or regions. Please contact your country representative for product availability and information ...
The E.coli derived recombinant protein contains the outer membrane T.Pallidum p41 immunodominant regions. The protein is fused ... pallidum pallidum, T. pallidum pertenue, T. pallidum carateum and T. pallidum endemicum. The helical structure of T. pallidum ... Treponema pallidum protein was purified by proprietary chromatographic technique.. Purity. Treponema pallidum protein is >90% ... Treponema pallidum sub sp. pallidum has one of the smallest bacterial genomes at 1.14 million base pairs (Mb) and has limited ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Analysis of serum IgG against Treponema pallidum protein antigens in experimentally infected rabbits. ... Analysis of serum IgG against Treponema pallidum protein antigens in experimentally infected rabbits. ... used to monitor the serum IgG response of experimentally infected rabbits against key protein antigens of Treponema pallidum. ... The sera from six rabbits challenged intradermally (ID) and six intratesticularly (IT) with T pallidum were examined over a ...
Background The TprK protein of the syphilis agent, Treponema pallidum subsp. pallidum (T. pallidum), undergoes antigenic ... the spirochete Treponema pallidum subsp. pallidum (T. pallidum) infects the fetus during pregnancy. Improving our understanding ... Treponema pallidum subsp. pallidum with an Artificially Impaired TprK Antigenic Variation System is Attenuated in the Rabbit ... Treponema pallidum subsp. pallidum with an Artificially Impaired TprK Antigenic Variation System is Attenuated in the Rabbit ...
Personalabs offers treponema pallidum antibodies tests at more than 4,000 affiliated locations nationwide. Order online and get ... Treponema Pallidum Antibody Test Preparation. You dont need to follow any specific instructions before taking the FTA-ABS test ... Personalabs offers you privacy and discretion when you order a Treponema pallidum AB test or any of our other STD tests. With a ... Who Should Take a Treponema Pallidum AB Test?. With syphilis, early testing is always better because swift treatment of an ...
Treponema Pallidum) antibodies Manufacturer Chi Shing Biotech Co. Ltd., Hong Kong Origin Hong Kong Window Period 45 days ...
Agglutination of Treponema pallidum in syphilitic serums Cite CITE. Title : Agglutination of Treponema pallidum in syphilitic ... Title : Agglutination of Treponema pallidum by reagin antibody Personal Author(s) : McLeod, Charlotte P.;Stokes, Peggie S.; ... McLeod, Charlotte P. and Stokes, Peggie S. "Agglutination of Treponema pallidum by reagin antibody" 70, no. 4 (1955). McLeod, ... McLeod, Charlotte P. and Magnuson, Harold J. "Agglutination of Treponema pallidum in syphilitic serums" vol. 68, no. 8, 1953. ...
Treponema pallidum). Risk of infection from oral sex:. *Giving oral sex to a partner with a syphilis sore or rash on the ...
Treponema pallidum) case definitions; uniform criteria used to define a disease for public health surveillance. ... Syphilis (Treponema pallidum) , 2018 Case Definition. *Syphilis (Treponema pallidum) , 2014 Case Definition ... Syphilis (Treponema pallidum) , 1996 Case Definition. *Syphilis (Treponema pallidum) , 1990 Case Definition ...
Treponema pallidum. (bacterium). Treponema pallidum is an aerobic, Gram-negative bacterium in the Spirochaetaceae family which ...
Treponema pallidum illustration for Sekisui Diagnostics. By We created a piece of art for Sekisui Diagnostics who produce ... This kit is for syphillis, which is caused by a bacterium called Treponema pallidum.. We used reference electron micrographs to ...
Sexually Transmitted Infection (STI) is a dreaded condition in all sexual lifestyle. Keep yourself safe. Get tested, with your partner. Its a two way interaction that could lead to disaster. Dont allow STI to limit fulfilling your joy and unforgettable, out of this world, moments.
The most famous of which is Treponema pallidum, which we call The Lady Proxima of Organisms. Why do we call treponema pallidum ... Treponema pallidum also is not thought to possess a T3SS (type three secretion system = bacterial artillery). Many pathogens ... Why is Treponema pallidum, the causal agent of Syphilis, also deemed the Lady Proxima of Organisms in our book? Well for a few ... Treponema pallidum does not have a lipopolysaccharide or LPS, which is often found in bacteria. ...
... antibodies to Treponema pallidum), a marker of syphilis without a visit to the laboratory from Lab24, quickly and qualitatively ... The causative agent of syphilis is Treponema pallidum (pale treponema), a bacterium from the family of spirochetes. Syphilis is ... Lab24 Infectious panel Treponemal test TPHA (antibodies to Treponema pallidum), a marker of syphilis ... Treponemal test TPHA (antibodies to Treponema pallidum), a marker of syphilis 58 zł ...
... well look into the fascinating world of treponema pallidum, exploring the many facts you should know about it. ... Can Treponema pallidum be Cultivated in the Laboratory?. Long-term cultivation of T. p. pallidum in a tissue-culture system has ... How is Treponema pallidum Identified in the Laboratory?. T. pallidum can be detected with special stains like the Dieterle ... What is the Significance of Treponema pallidums Genome Sequencing?. The genome sequencing of T. pallidum in 1998 played an ...
Treponema Pallidum. Biologie, patogenie si ghid de diagnostic la preturi mici ... Treponema Pallidum. Biologie, patogenie si ghid de diagnostic : acceseaza rubrica noastra Medicina pentru cele mai multe oferte ...
A highly contagious infection caused by the Treponema pallidum bacteria, Syphilis is one of the most common sexually ... Treponema Pallidum; Reverse Algorithm; T. Pallidum; Treponema Pallidum Antibodies ... Treponema Pallidum; Reverse Algorithm; T. Pallidum; Treponema Pallidum Antibodies ... Treponema Pallidum (Syphilis) Screening Cascade Blood Test The Treponema Pallidum (Syphilis) Screening Cascade test screens for ...
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Footprint of Positive Selection in Treponema pallidum subsp. pallidum Genome Sequences Suggests Adaptive Microevolution of the ... Footprint of Positive Selection in Treponema pallidum subsp. pallidum Genome Sequences Suggests Adaptive Microevolution of the ... infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are ... Sequencing of 16 genomic loci harboring SNPs in 12 additional T. pallidum strains, (SS14, Bal 3, Bal 7, Bal 9, Sea 81-3, Sea 81 ...
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... von Filipa M.D Paciência ... Here, nonhuman primates (NHPs) are infected by Treponema pallidum (TP), a bacterium known to cause conspicuous genital ... Keywords: Papio anubis; olive baboon; mating behaviour; sexual behaviour; treponema pallidum; sexually transmitted infections; ... approach linking humans and wildlife when investigating the impact of shared pathogens like Treponema pallidum. ...
... BABOLIN, CHIARA;Amedei ... With this study, we demonstrate for the first time, to our knowledge, that Treponema pallidum induces a regulatory T (Treg) ... With this study, we demonstrate for the first time, to our knowledge, that Treponema pallidum induces a regulatory T (Treg) ... Human syphilis is a multistage disease, with diverse and wide-ranging manifestations caused by Treponema pallidum. Despite the ...
Syphilis (Treponema pallidum). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennetts Principles and Practice ... Syphilis is a sexually transmitted infectious (STI) disease caused by the bacterium Treponema pallidum. This bacterium causes ... Primary syphilis; Secondary syphilis; Late syphilis; Tertiary syphilis; Treponema - syphilis; Lues; Sexually transmitted ...
Treponema pallidum particle agglutination (TP-PA) The Serodia TP-PA test is a treponemal test for the serologic detection of ... Serodia Treponema pallidum passive particle agglutination (TP-PA) test, In: Larsen SA, Pope V, Johnson, RE, and Kennedy EJ, Jr ... LBDSY4 = Treponema pallidum particle agglutination (TP-PA) Positive serologic evidence of syphilis, more likely recent ... Syphilis-IgG, Syphilis Rapid Plasma Reagin (RPR) & Treponema pallidum Particle Agglutination (TP-PA) (L36_C). Data File: L36_C. ...
... was used to examine the native cellular organization of Treponema pallidum, the syphilis spirochete. T. pallidum cells appeared ... was used to examine the native cellular organization of Treponema pallidum, the syphilis spirochete. T. pallidum cells appeared ... was used to examine the native cellular organization of Treponema pallidum, the syphilis spirochete. T. pallidum cells appeared ... was used to examine the native cellular organization of Treponema pallidum, the syphilis spirochete. T. pallidum cells appeared ...
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  • Treponema pallidum, formerly known as Spirochaeta pallida, is a spirochaete bacterium with various subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws. (
  • Three subspecies of T. pallidum are known: Treponema pallidum pallidum, which causes syphilis T. p. endemicum, which causes bejel or endemic syphilis T. p. pertenue, which causes yaws The three subspecies causing yaws, bejel, and syphilis are morphologically and serologically indistinguishable. (
  • Acquisition by the syphilis spirochaete, Treponema pallidum, of radioiodinated total human plasma lipoprotein and lipoprotein subfractions was examined. (
  • Treponema pallidum, the bacterial agent of syphilis, is predicted to encode one tripartite ATP-independent periplasmic transporter (TRAP-T). TRAP-Ts typically employ a periplasmic substrate-binding protein (SBP) to deliver the cognate ligand to the transmembrane symporter. (
  • pallidum is the causative agent of syphilis (Lues), a disease occurring only in humans. (
  • 2 Additionally, T. pallidum can be transmitted to the foetus from an infected mother during pregnancy (congenital syphilis). (
  • Syphilis, caused by the bacterium Treponema pallidum, is spread by either sexual contact or transmission from a pregnant woman to her fetus. (
  • Treponemal tests include the fluorescent treponemal antibody absorption (FTA-ABS) test, the hemagglutination treponemal test for syphilis (HATTS), the T pallidum hemagglutination assay (TPHA), and the microhemagglutination test for T pallidum (MHA-TP). (
  • The ATFirst™ Syphilis Ab Combo Rapid Test is a lateral flow chromatographic immunoassay for the qualitative detection of antibodies (IgG, IgM and IgA) to Treponema pallidum (Tp) in human serum, plasma or whole blood. (
  • This syphilis ( T. pallidum ) assay is a useful screening tool because antibodies against Treponema subspecies are cross-reactive ( 6 ). (
  • The treponema pallidum hemagglutination or TPHA test is primarily prescribed by doctors to detect the presence of certain antibodies directly involved with the disease syphilis. (
  • Syphilis is a disease that can be transmitted via sexual intercourse due to the bacteria called treponema pallidum. (
  • Syphilis is a sexually transmitted infectious (STI) disease caused by the bacterium Treponema pallidum . (
  • Without some other evidence for the diagnosis of syphilis, a reactive nontreponemal test does not confirm T. pallidum infection. (
  • The Serodia TP-PA test is a treponemal test for the serologic detection of antibodies to the various species and subspecies of pathogenic Treponema , the causative agents of syphilis, yaws, pinta, bejel, and endemic syphilis. (
  • To explore whether fibroblasts participate in inflammation due to syphilis , a series of experiments were performed to explore the role of T. pallidum lipoprotein Tp47 in IL-6 production in human dermal fibroblasts . (
  • Treponema pallidum, cause of syphilis infection. (
  • The Centers for Disease Control and Prevention (CDC) publishes annual summaries of national surveillance data for notifiable diseases covered by federally-funded control programs, including Chlamydia trachomatis (chlamydia), Neisseria gonorrhoeae (gonorrhea), and Treponema pallidum (syphilis). (
  • Syphilis, caused by the bacterium Treponema pallidum subsp. (
  • Syphilis is a sexually transmitted disease (STD) caused by the bacterium Treponema pallidum . (
  • Another important bacterial STI is syphilis, which is caused by the bacterium Treponema pallidum . (
  • Syphilis is caused by an organism called Treponema pallidum. (
  • Syphilis is a common sexually transmitted infection caused by a bacterial infection, this infectious organism is known as Treponema pallidum. (
  • Syphilis is a sexually transmitted infection caused by a microorganism called Treponema pallidum. (
  • Latent syphilis is the presence of Treponema pallidum bacteria without any symptoms of primary, secondary or tertiary infection. (
  • DIAGNOSIS OF SYPHILIS IN HIV-INFECTED PATIENTS Most HIV-infected patients appear to have a normal serologic response to Treponema pallidum infection (2). (
  • In addition, some patients infected with both T. pallidum and HIV have had unusually high titers on nontreponemal serologic tests for syphilis (CDC, unpublished data, 1987-88), possibly because of HIV-related polyclonal B-cell stimulation. (
  • Y to perform repeated testing with a preabsorption step to aws is a disease caused by the bacterium Treponema remove all nonspecific binding antibodies (as described in pallidum subsp. (
  • Yaws is a disease caused by the bacterium Treponema pallidum subsp. (
  • A sexually transmitted infection caused by the bacterium Treponema pallidum . (
  • T. pallidum consists of three subspecies, T. p. pallidum, T. p. endemicum, and T. p. pertenue, each of which has a distinct associated disease. (
  • T. p. pallidum is the most invasive pathogenic subspecies, while T. carateum is the least invasive of the species. (
  • The chromosomes of the T. pallidum subspecies are small, about 1.14 Mbp. (
  • Treponema subspecies are cross-reactive ( 6 ). (
  • Treponema pallidum includes three subspecies of antigenically highly related treponemes. (
  • In this report, genetic signatures are identified in two tpr genes which, in combination with the previously published signature in the 5' flanking region of the tpp15 gene, can differentiate the T. pallidum subspecies, as well as a simian treponeme. (
  • The genus Treponema pallidum comprises several human pathogen species and subspecies. (
  • Restriction fragments of 334 and 159 bp are seen only in T. pallidum subsp. (
  • A BsrDI restriction site is found in the T. pallidum subsp. (
  • endemicum (Bosnia A and Iraq B) isolates, the Fribourg-Blanc isolate, and in the T. pallidum subsp. (
  • The BsiEI restriction site (572- and 135-bp fragments) is present in the T. pallidum subsp. (
  • pallidum Sea 81-3 and Mexico A strains which lack the BsrDI restriction site and differentiates them from the T. pallidum subsp. (
  • The T. pallidum subsp. (
  • Treponema pallidum subsp. (
  • Penicillin-binding proteins and peptidoglycan of Treponema pallidum subsp. (
  • Dive into the research topics of 'Penicillin-binding proteins and peptidoglycan of Treponema pallidum subsp. (
  • Yaws: The first report of the emergence of azithromycin-resistant Treponema pallidum subsp. (
  • Genome-wide integrative analysis of DNA methylation and transcriptional expression of different lineages of Treponema pallidum subsp. (
  • Haemophilus ducreyi (HD) and Treponema pallidum subsp. (
  • Treponema pallidum is a helically shaped bacterium with high mobility consisting of an outer membrane, peptidoglycan layer, inner membrane, protoplasmic cylinder, and periplasmic space. (
  • A clinical, serological and molecular follow-up was performed to detect active yaws cases (i.e. ulcers where the presence of the causal agent, Treponema pallidum pertenue , was confirmed by DNA amplification). (
  • BamA apparatus will insert newly synthetised and exported outer membrane proteins into the outer membrane The Treponema repeat family of proteins (Tpr) are proteins expressed during the infection process. (
  • The assessment of Treponema pallidum-specific IgM antibodies for the check of the treatment indication of a Treponema infection is suitable for the normal course of infection. (
  • However, a more recent study of baboon samples collected during 1977-1994 in Kenya reported serologic evidence of T. pallidum infection in Nanyuki, Laikipia County (prevalence 57.5%) ( 5 ). (
  • The procedure is simple as it only requires a blood test which is then used to measure the number of pallidum antibodies present in the bloodstream of a patient to detect the exact level of infection. (
  • Cytokine expression in Treponema pallidum infection. (
  • This has not yet been confirmed, but because an intact cellular immune response is important in the host response to T. pallidum infection (7) and because HIV infection impairs cellular immune response in some patients, an increased frequency of treatment failure is plausible. (
  • In medical terms, the entire testing process for a TPHA test is by sensitizing the red blood cells present in the blood with the treponema pallidum antibody fragments. (
  • Human yaws has historically been endemic to Kenya, but pallidum Particle Agglutination Assay (TPPA) (SERODIA current epidemiologic data are lacking. (
  • Treponema pallidum LINE Immunoblot assay is for in vitro diagnostic (IVD) use for the qualitative detection of Treponema pallidum specific IgG-/IgM-antibodies respectively in human serum. (
  • The Treponema pallidum LINE Immunoblot assay is a strip-based method using recombinant proteins applied in well-defined positions to nitrocellulose strip by a micro-dispensing method. (
  • However, because this test is not certified for use with NHPs, we subsequently confirmed results by using the T. pallidum Particle Agglutination Assay (TPPA) (SERODIA TPPA, ), which has been validated for use in baboons ( 7 ). (
  • Although 72 (65%) of 111 serum samples from Guinea were positive for T. pallidum antibodies, none of the samples from Kenya were positive. (
  • In subsequent years, an additional 276 serum samples from baboons in Kenya supported the absence of T. pallidum in- Seroprevalence of fection. (
  • Serum lipoprotein binding by Treponema pallidum: possible role for proteoglycans. (
  • Diagnosis and test of cure were based on toluidine red unheated serum tests (TRUSTs) and Treponema pallidum hemagglutination assays. (
  • A dilution of the patient's serum is added to the well to allow any T. pallidum -specific antibodies present to bind to the treponemal antigens. (
  • The Treponema Pallidum Haemagglutination test in Singapore may be done at Shim Clinic. (
  • TREPONEMA PALLIDUM HAEMAGGLUTINATION blood test in Khambhalia is done at fully automated NABL accredited diagnostic laboratory Thyrocare which has Centralized Processing Lab in Mumbai for esoteric tests and Regional Processing Labs in major cities of India. (
  • Mediyaar Healthcare in Khambhalia provides online facility for booking of TREPONEMA PALLIDUM HAEMAGGLUTINATION where sample can be collected from your home or offce in Khambhalia. (
  • Only 5% and 10% of associated radioactivity was released from treponemal surfaces after T pallidum was incubated with iodinated LDL and 17% sulphated-DS for 15 and 30 minutes, respectively. (
  • Treponemal specific antibodies, which react with T. pallidum and related strains. (
  • These tests include dark-field microscopy and direct fluorescent antibody for T. pallidum (DFA-TP) staining of lesion exudate and examination of biopsy tissue using DFA-TP or Steiner stain (4). (
  • These data show binding and possible internalisation of host lipoproteins by T pallidum, which may be mediated by sulphated proteoglycan. (
  • By special staining technique, a spiral organism was found in the brain exhibiting morphology perfectly compatible with treponema pallidum. (
  • email: [email protected] dynamics and potential links between human and NHP T. pallidum strains ( 3 ). (
  • However, sustainable yaws eradication will rely on information about transmission dynamics and potential links between human and NHP T. pallidum strains ( 3 ). (
  • We report seroprevalence for Treponema pallidum antibodies in olive baboons ( Papio anubis ) and vervet monkeys ( Chlorocebus pygerythrus ) in Laikipia County, Kenya. (
  • The presence of peptidoglycan in T. pallidum was confirmed by the detection of muramic acid in the sodium dodecyl sulfate-insoluble, proteinase K-resistant residue obtained from Triton X-114-extracted organisms. (
  • Whether fibroblasts also turn out to be a cytokine IL-6 factory during interaction with Treponema pallidum is not yet understood. (
  • Treponema carateum, the cause of pinta, remains a separate species because no isolate is available for DNA analysis. (
  • The genus Treponema has ribbons of cytoskeletal cytoplasmic filaments that run the length of the cell just underneath the cytoplasmic membrane. (
  • pallidum (T. pallidum) were characterized by using [ 3 H]penicillin G and a conjugate consisting of ampicillin and 125 I-labeled Bolton-Hunter reagent. (
  • pallidum (T. pallidum) were characterized by using [3H]penicillin G and a conjugate consisting of ampicillin and 125I-labeled Bolton-Hunter reagent. (
  • TprK antigen variation can help T. pallidum to evade a strong host immune reaction and can also allow the reinfection of individuals. (
  • pallidum Nichols, Chicago, and Sea 81-4 isolates, yielding fragments of 547 and 160 bp. (
  • It is desirable to differentiate between IgG and IgM-specific Treponema-antibodies. (
  • Oral sex is also an important route of transmitting Treponema pallidum where the transmission can occur despite the use of condoms. (
  • 2 As T. pallidum cannot be cultured in vitro 1 , diagnosis depends on serological analysis. (
  • The interaction of LDL with T pallidum was studied further and, interestingly, the presence of 17% sulphated dextran sulphate (DS) in the reaction mixture containing treponemes and LDL resulted in up to 172 times more LDL being bound by live treponemes. (
  • Treponema pallidum recombinant protein Tp47 enhanced interleukin-6 secretion in human dermal fibroblasts through the toll-like receptor 2 via the p38, PI3K/Akt, and NF-κB signalling pathways. (
  • Herein, we demonstrate that the genes encoding the putative TRAP-T components from T. pallidum, tp0957 (the SBP), and tp0958 (the symporter), are in an operon with an uncharacterized third gene, tp0956. (
  • A report from San Francisco in 2001 was the first to associate azithromycin treatment failure with A→G mutations at the 2,058 position of the 23S rRNA gene of T. pallidum . (
  • Biological variability was observed in the extent of increased LDL bound in the presence of 17% sulphated DS by preparations of T pallidum isolated from different infected rabbits. (
  • The presence of specific IgG-respectively IgM antibodies to Treponema pallidum can be detected within 2,5 hrs. (
  • pallidum (TPA) is considered a re-emerging disease with over 5.6 million cases worldwide. (
  • Bartonella henselae , Treponema pallidum, and Mycobacterium tuberculosis are the organisms most often responsible for primary bacterial infections of the optic nerve. (
  • Sulphated proteoglycans accumulate during T pallidum infections of host cells. (
  • This sequencing is significant due to T. pallidum not being capable of growing in a pure culture, meaning that this sequencing played an important role in understanding the microbes' functions. (