A genus of microorganisms of the order SPIROCHAETALES, many of which are pathogenic and parasitic for man and animals.
The causative agent of venereal and non-venereal syphilis as well as yaws.
A species of bacteria in the family SPIROCHAETACEAE, frequently isolated from periodontal pockets (PERIODONTAL POCKET).
Infections with bacteria of the genus TREPONEMA.
A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.
Syphilis serodiagnosis employing as the antigen Treponema pallidum obtained from rabbit syphilis orchitis. Treponemes are kept alive for a few hours in a special medium. When syphilitic serum and complement are added and incubated, the treponemes are immobilized, i.e., stop moving.
A systemic non-venereal infection of the tropics caused by TREPONEMA PALLIDUM subspecies pertenue.
Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.
Serologic tests for syphilis.
A family of spiral bacteria of the order SPIROCHAETALES.
A genus of flexible, spiral rods found in hydrogen sulfide-containing mud, sewage, and polluted water. None of the species properly referred to in this genus are pathogenic.
An order of slender, flexuous, helically coiled bacteria, with one or more complete turns in the helix.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Highly contagious infectious dermatitis with lesions near the interdigital spaces usually in cattle. It causes discomfort and often severe lameness (LAMENESS, ANIMAL). Lesions can be either erosive or proliferative and wart-like with papillary growths and hypertrophied hairs. DICHELOBACTER NODOSUS and TREPONEMA are the most commonly associated causative agents for this mixed bacterial infection disease.
Syphilis acquired in utero and manifested by any of several characteristic tooth (Hutchinson's teeth) or bone malformations and by active mucocutaneous syphilis at birth or shortly thereafter. Ocular and neurologic changes may also occur.
Substances elaborated by bacteria that have antigenic activity.
Cutaneous lesions arising from infection with Treponema pallidum. In the primary stage, 18-21 days following infection, one or more chancres appear. If untreated, the subsequent stages of the disease appear as syphilids. These eruptions are superficial, nondestructive, exanthematic, transient, macular roseolas that may later be maculopapular or papular polymorphous or scaly, pustular, pigmented eruptions.(Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p409)
The primary sore of syphilis, a painless indurated, eroded papule, occurring at the site of entry of the infection.
An acute or chronic GINGIVITIS characterized by redness and swelling, NECROSIS extending from the interdental papillae along the gingival margins, PAIN; HEMORRHAGE, necrotic odor, and often a pseudomembrane. The condition may extend to the ORAL MUCOSA; TONGUE; PALATE; or PHARYNX. The etiology is somewhat unclear, but may involve a complex of FUSOBACTERIUM NUCLEATUM along with spirochetes BORRELIA or TREPONEMA.
Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)
Any inflammation of the skin.
Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
Proteins found in any species of bacterium.
The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.
Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)
A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.
A species of anaerobic, spiral bacteria that was formerly classified as Serpulina hyodysenteriae and Treponema hyodysenteriae (and for a short while, Serpula hyodysenteriae). This organism is the agent of swine dysentery.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Oral tissue surrounding and attached to TEETH.
An abnormal extension of a gingival sulcus accompanied by the apical migration of the epithelial attachment and bone resorption.
Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine.
Anatomical and functional disorders affecting the foot.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A whiplike motility appendage present on the surface cells. Prokaryote flagella are composed of a protein called FLAGELLIN. Bacteria can have a single flagellum, a tuft at one pole, or multiple flagella covering the entire surface. In eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella have the same basic structure as CILIA but are longer in proportion to the cell bearing them and present in much smaller numbers. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
The external and internal organs related to reproduction.
Diseases of domestic swine and of the wild boar of the genus Sus.
Proteins isolated from the outer membrane of Gram-negative bacteria.
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
An infectious disease of the skin caused by Treponema carateum that occurs only in the western hemisphere. Age of onset is between 10 and 20 years of age. This condition is characterized by marked changes in the skin color and is believed to be transmitted by direct person-to-person contact.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Immunoglobulins produced in response to VIRAL ANTIGENS.

Activation of murine macrophages by lipoprotein and lipooligosaccharide of Treponema denticola. (1/399)

We have recently demonstrated that the periodontopathogenic oral spirochete Treponema denticola possesses membrane-associated lipoproteins in addition to lipooligosaccharide (LOS). The aim of the present study was to test the potential of these oral spirochetal components to induce the production of inflammatory mediators by human macrophages, which in turn may stimulate tissue breakdown as observed in periodontal diseases. An enriched lipoprotein fraction (dLPP) from T. denticola ATCC 35404 obtained upon extraction of the treponemes with Triton X-114 was found to stimulate the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha), and interleukin-1 (IL-1) by mouse macrophages in a dose-dependent manner. Induction of NO by dLPP was at 25% of the levels obtained by Salmonella typhosa lipopolysaccharide (LPS) at similar concentrations, while IL-1 was produced at similar levels by both inducers. dLPP-mediated macrophage activation was unaffected by amounts of polymyxin B that neutralized the induction produced by S. typhosa LPS. dLPP also induced NO and TNF-alpha secretion from macrophages isolated from endotoxin-unresponsive C3H/HeJ mice to an extent similar to the stimulation produced in endotoxin-responsive mice. Purified T. denticola LOS also produced a concentration-dependent activation of NO and TNF-alpha in LPS-responsive and -nonresponsive mouse macrophages. However, macrophage activation by LOS was inhibited by polymyxin B. These results suggest that T. denticola lipoproteins and LOS may play a role in the inflammatory processes that characterize periodontal diseases.  (+info)

Treponema denticola outer membrane enhances the phagocytosis of collagen-coated beads by gingival fibroblasts. (2/399)

Human gingival fibroblasts (HGFs) degrade collagen fibrils in physiological processes by phagocytosis. Since Treponema denticola outer membrane (OM) extract perturbs actin filaments, important structures in phagocytosis, we determined whether the OM affects collagen phagocytosis in vitro by HGFs. Phagocytosis was measured by flow cytometric assessment of internalized collagen-coated fluorescent latex beads. Confluent HGFs pretreated with T. denticola ATCC 35405 OM exhibited an increase in the percentage of collagen phagocytic cells (phagocytosis index [PI]) and in the number of beads per phagocytosing cell (phagocytic capacity [PC]) compared with untreated controls. The enhancement was swift (within 15 min) and was still evident after 1 day. PI and PC of HGFs for bovine serum albumin (BSA)-coated beads were also increased, indicating a global increase in phagocytic processes. These results contrasted those for control OM from Veillonella atypica ATCC 17744, which decreased phagocytosis. The T. denticola OM-induced increase in bead uptake was eliminated by heating the OM and by depolymerization of actin filaments by cytochalasin D treatment of HGFs. Fluid-phase accumulation of lucifer yellow was enhanced in a saturable, concentration-dependent, transient manner by the T. denticola OM. Our findings were not due to HGF detachment or cytotoxicity in response to the T. denticola OM treatment since the HGFs exhibited minimal detachment from the substratum; they did not take up propidium iodide; and there was no change in their size, granularity, or content of sub-G1 DNA. We conclude that a heat-sensitive component(s) in T. denticola OM extract stimulates collagen phagocytosis and other endocytic processes such as nonspecific phagocytosis and pinocytosis by HGFs.  (+info)

Treponema brennaborense sp. nov., a novel spirochaete isolated from a dairy cow suffering from digital dermatitis. (3/399)

A novel Treponema species was isolated from an ulcerative lesion of a cow suffering from digital dermatitis (DD), a disease which causes painful ulcerations along the coronary band. Among other anaerobic bacteria, high numbers of spirochaetes have been regularly found in DD lesions. Here data are presented of a spirochaete isolated from a DD ulcer. By chemotaxonomy, protein analysis and comparative 16S rDNA sequence analysis this isolate was classified as a treponeme that differed from all Treponema species described previously. The only isolate, DD5/3T, for which the name Treponema brennaborense is proposed, is designated the type strain of the novel species. The strain is a small, highly motile spirochaete that has two periplasmic flagella, one flagellum being attached at each cell pole. Strain DD5/3T exhibits alpha-glucosidase and N-acetyl-beta-glucosaminidase activity and growth is inhibited by rabbit serum. T. brennaborense was phylogenetically most closely related (89.5% 16S rRNA similarity) to Treponema maltophilum, an oral spirochaete isolated from a periodontitis patient.  (+info)

Cystalysin, a 46-kDa L-cysteine desulfhydrase from Treponema denticola: biochemical and biophysical characterization. (4/399)

A 46-kDa hemolytic protein referred to as cystalysin, from Treponema denticola ATCC 35404, was characterized and overexpressed in Escherichia coli LC-67. Cystalysin lysed erythrocytes, hemoxidized hemoglobin to sulfhemoglobin and methemoglobin, and removed the sulfhydryl and amino group from selected S-containing compounds (e.g., cysteine) producing H2S, NH3, and pyruvate. With L-cysteine as substrate, cystalysin obeys Michaelis-Menten kinetics. Cystathionine and s-aminoethyl-L-cysteine were also substrates. Several of the small alpha amino acids were found to be competitive inhibitors of cystalysin. The enzymatic activity was increased by beta-mercaptoethanol and was not inhibited by the proteinase inhibitor TLCK (N alpha-p-tosyl-L-lysine chloromethyl ketone), pronase, or proteinase K, suggesting the functional site was physically protected or located in a small fragment of the polypeptide. We hypothesize that cystalysin is a pyridoxal-5-phosphate-containing enzyme with the activity of an alphaC-N and betaC-S lyase (cystathionase). Since high amounts of H2S have been reported in deep periodontal pockets, this metabolic enzyme from T. denticola may also function in vivo as an important virulence molecule.  (+info)

Glyceraldehyde-3-phosphate dehydrogenase gene diversity in eubacteria and eukaryotes: evidence for intra- and inter-kingdom gene transfer. (5/399)

Cyanobacteria contain up to three highly divergent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) genes: gap1, gap2, and gap3. Genes gap1 and gap2 are closely related at the sequence level to the nuclear genes encoding cytosolic and chloroplast GAPDH of higher plants and have recently been shown to play distinct key roles in catabolic and anabolic carbon flow, respectively, of the unicellular cyanobacterium Synechocystis sp. PCC6803. In the present study, sequences of 10 GAPDH genes distributed across the cyanobacteria Prochloron didemni, Gloeobacter violaceus PCC7421, and Synechococcus PCC7942 and the alpha-proteobacterium Paracoccus denitrificans and the beta-proteobacterium Ralstonia solanacearum were determined. Prochloron didemni possesses homologs to the gap2 and gap3 genes from Anabaena, Gloeobacter harbors gap1 and gap2 homologs, and Synechococcus possesses gap1, gap2, and gap3. Paracoccus harbors two highly divergent gap genes that are related to gap3, and Ralstonia possesses a homolog of the gap1 gene. Phylogenetic analyses of these sequences in the context of other eubacterial and eukaryotic GAPDH genes reveal that divergence across eubacterial gap1, and gap2, and gap3 genes is greater than that between eubacterial gap1 and eukaroytic glycolytic GapC or between eubacterial gap2 and eukaryotic Calvin cycle GapAB. These data strongly support previous analyses which suggested that eukaryotes acquired their nuclear genes for GapC and GapAB via endosymbiotic gene transfer from the antecedents of mitochondria and chloroplasts, and extend the known range of sequence diversity of the antecedent eubacterial genes. Analyses of available GAPDH sequences from other eubacterial sources indicate that the glycosomal gap gene from trypanosomes (cytosolic in Euglena) and the gap gene from the spirochete Treponema pallidum are each other's closest relatives. This specific relationship can therefore not reflect organismal evolution but must be the result of an interkingdom gene transfer, the direction of which cannot be determined with certainty at present. Contrary to this, the origin of the cytosolic Gap gene from trypanosomes can now be clearly defined as gamma-proteobacterial, since the newly established Ralstonia sequence (beta-proteobacteria) branches basally to the gamma-proteobacterial/trypanosomal assemblage.  (+info)

Environmental modulation of oral treponeme virulence in a murine model. (6/399)

This investigation examined the effects of environmental alteration on the virulence of the oral treponemes Treponema denticola and Treponema pectinovorum. The environmental effects were assessed by using a model of localized inflammatory abscesses in mice. In vitro growth of T. denticola and T. pectinovorum as a function of modification of the cysteine concentration significantly enhanced abscess formation and size. In contrast, growth of T. denticola or T. pectinovorum under iron-limiting conditions (e.g., dipyridyl chelation) had no effect on abscess induction in comparison to that when the strains were grown under normal iron conditions. In vivo modulation of the microenvironment at the focus of infection with Cytodex beads demonstrated that increasing the local inflammation had no effect on lesion induction or size. In vivo studies involved the determination of the effects of increased systemic iron availability (e.g., iron dextran or phenylhydrazine) on the induction, kinetics, and size of lesions. T. denticola induced significantly larger lesions in mice with iron pretreatment and demonstrated systemic manifestations of the infectious challenge and an accompanying spreading lesion with phenylhydrazine pretreatment (e.g., increases in circulating free hemoglobin). In contrast, T. pectinovorum virulence was minimally affected by this in vivo treatment to increase iron availability. T. denticola virulence, as evaluated by lesion size, was increased additively by in vivo iron availability, and cysteine modified growth of the microorganism. Additionally, galactosamine sensitized mice to a lethal outcome following infection with both T. denticola and T. pectinovorum, suggesting an endotoxin-like activity in these treponemes. These findings demonstrated the ability to modify the virulence capacity of T. denticola and T. pectinovorum by environmental conditions which can be evaluated by using in vivo murine models.  (+info)

Insertional inactivation of Treponema denticola tap1 results in a nonmotile mutant with elongated flagellar hooks. (7/399)

The treponemal fla operon is comprised of numerous motility-related genes; however, the initial gene of this operon, tap1, has no known function. A recently developed system to generate specific mutants in Treponema denticola was utilized to determine if Tap1 was essential for motility. T. denticola tap1 and flanking DNA were identified, cloned, and sequenced, and a suicide plasmid that contained tap1 interrupted with an erythromycin resistance cassette (ermF and ermAM) was constructed. Because of potential polar effects from this cassette, a second plasmid that contained tap1 interrupted with a modified erythromycin resistance cassette that lacked the putative ermF transcription terminator was constructed. Electroporation-mediated allelic exchange incorporated the interrupted tap1 genes into the T. denticola chromosome, creating Tap1-deficient mutants. Reverse transcriptase PCR revealed that the erythromycin resistance cassette within tap1 did not terminate fla operon transcription in either mutant. Moreover, the phenotypes of the two mutants were indistinguishable. These mutants lacked motion in liquid culture, were unable to spread on agar plates, and lacked flagellar filaments as determined by electron microscopy. Immunoblots revealed a marked reduction in detectable FlaB flagellar filament protein compared to that of wild type; however, flaB RNA was easily detectable, and transcription levels did not appear to be altered. The basis for the lack of filament protein expression is unknown. Immunoblotting also showed that the flagellar hook protein (FlgE) was synthesized in the Tap1-deficient mutant; however, electron microscopy revealed that the mutant possessed unusual elongated hooks of variable lengths. We propose that treponemal Tap1 is analogous to FliK, which is involved in monitoring the flagellar hook length of Salmonella typhimurium.  (+info)

Development of a system for expressing heterologous genes in the oral spirochete Treponema denticola and its use in expression of the Treponema pallidum flaA gene. (8/399)

The present communication describes the construction of a new Escherichia coli-Treponema denticola shuttle vector based on the naturally occurring spirochete plasmid pTS1 and the expression of the heterologous T. pallidum flaA gene from the plasmid in T. denticola. This new shuttle vector system should prove useful in characterizing virulence factors from unculturable pathogenic spirochetes.  (+info)

Treponema hyodysenteriae was shown to attach to mouse peritoneal cells in the absence of serum opsonins in vitro. If serotype-specific antiserum from pigs was added to the media and treponemes of that corresponding serotype were employed in the assay, the amount of attachment increased an average of 3.7 times that of the control without pig sera. However, the amount of attachment was increased an average of only 1.5 times that of the control if organisms of any noncorresponding serotype of T. hyodysenteriae were used in the assay. Since the lipopolysaccharide (LPS) extracted from T. hyodysenteriae is the basis for serotyping the treponeme, the ability of these distinct LPS types to block attachment by blocking opsonization of the organisms was tested. Attachment, using corresponding antisera and treponemes, was blocked by LPS extracted from treponemes of that serotype, but not by LPS extracted from treponemes of other serotypes. These results indicate that antibody response to T. hyodysenteriae ...
Digital dermatitis in cattle is an emerging infectious disease. Ulcerative lesions are typically located on the plantar skin between the heel bulbs and adjacent to the coronet. Spirochetes of the genus Treponema are found in high numbers in the lesions and are likely to be involved in the pathogenesis. The aim of this study was to obtain pure cultures of spirochetes from cattle with digital dermatitis and to describe them further. Tissue samples and swabs from active digital dermatitis lesions were used for culturing. Pure isolates were subjected to, molecular typing through 16S rRNA gene sequencing, pulsed-field gel electrophoresis (PFGE), random amplified polymorphic DNA (RAPD) and an intergenic spacer PCR developed for Treponema spp. as well as API-ZYM and antimicrobial susceptibility tests. The antimicrobial agents used were tiamulin, valnemulin, tylosin, aivlosin, lincomycin and doxycycline. Seven spirochete isolates from five herds were obtained. Both 16S rRNA gene sequences, which were identical
This study investigated the presence of the Treponema species in longstanding endodontic retreatment-resistant lesions of teeth with apical periodontitis, the association of this species with clinical/radiographic features, and the association among the different target species. Microbial samples of apical lesions were collected from twenty-five adult patients referred to endodontic surgery after unsuccessful root canal retreatment. Nested-PCR and conventional PCR were used for Treponema detection. Twenty-three periradicular tissue samples showed detectable levels of bacterial DNA. Treponema species were detected in 28% (7/25) of the cases. The most frequently detected species were T. socranskii (6/25), followed by T. maltophilum (3/25), T. amylovorum (3/25), T. lecithinolyticum (3/25), T. denticola (3/25), T. pectinovorum (2/25) and T. medium (2/25). T. vicentii was not detected in any sample. Positive statistical association was found between T. socranskii and T. denticola, and between T. ...
In this study, a comprehensive review of the literature was carried out to identify all Treponema species isolated from human samples. We determined that, to date, 284 strains from 13 different Treponema species, including T. pectinovorum, T. socranskii, T. denticola, T. vincentii, T. maltophilum, T. medium, T. amylovorum, T. lecithinolyticum, T. parvum, T. putidum, T. phagedenis, T. minutum, and T. refringens, have been isolated from human oral and skin samples. Metagenomic studies have demonstrated the presence of uncultivated Treponema species in the human oral cavity and gut (9, 14-17). In our laboratory, we have paid particular attention to the culture of this bacterial genus, to develop and to implement a new method for the detection, isolation, and identification of Treponema strains. We have combined three different techniques, namely, the use of a new electron microscope (Hitachi TM4000) to detect the presence of Treponema in clinical specimens, a new culture technique based on passive ...
Treponema is a genus of spiral-shaped bacteria. The major treponeme species of human pathogens is Treponema pallidum, whose subspecies are responsible for diseases such as syphilis, bejel, and yaws. Treponema carateum is the cause of pinta.[1] Treponema paraluiscuniculi is associated with syphilis in rabbits.[2] ...
The pattern of serological cross-reactivity between Q1, A1 and WA1 was complex and was not fully defined, but the isolate Q1 apparently shared low molecular weight serogroup LPS antigens with A1, and shared higher molecular weight LPS antigens with WA1. On this basis Q1 was designated as belonging to serogroup D, although it was recommended that this be qualified as D (B) to indicate the presence of weak cross-reactivity with serogroup B. Such serological cross-reactivity may have significance in relation to the development of immunity to T. hyodysenteriae. Isolate Q1 may be a potentially useful organism for vaccine development because of its ability to induce a good serological response to LPS of treponemes from both serogroups D and B.. ...
Treponema sp. Colour scanning electron micrograph of a colony of bacteria Treponema sp. (blue), attached to the epithelial surface of the human duodenum (pink). Epithelial cell surfaces appear noduled. These elongated spiral-shaped bacteria (spirochaetes) lack rigid cell walls. Pathogenic species of Treponema include T.pallidum which causes syphilis; T. carateum which causes the skin disease pinta in tropical America; T. pertenue which causes yaws in Africa. In syphilis, the bacteria may be found on the duodenum, as seen here, as well as in most other parts of the body. Magnification: x7,600 at 6x7cm size. 24,000 at 10x8 - Stock Image B220/1007
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar ...
Postdoctoral Fellow Position in Host- Pathogen Interactions University at Buffalo, The State University of New York. Laboratory of Michelle Visser. A postdoctoral fellow position is available immediately to study molecular interactions between Treponema species and the human host.. Spirochetes are a diverse group of bacteria responsible for many important health conditions including periodontal disease, syphilis, Lyme disease and other tick-borne diseases. The Visser lab studies how spirochete outer membrane proteins and outer membrane vesicles from various Treponema species modulate inflammation and cellular response during disease as well as the connection with systemic conditions such as atherosclerosis and neurological impairment. Much of the work in the Visser lab focuses on how these virulence factors and their active epitopes modulate neutrophil response. Ongoing projects include understanding the role of differential neutrophil cytokine response, extracellular matrix remodeling, aortic ...
Digital dermatitis (DD), first described in 1974 by Cheli and Mortellaro (R. Cheli and C. Mortellaro, p. 208-213, in Proceedings of the 8th International Conference on Diseases of Cattle, 1974), is a major problem in diary cows and beef cattle causing significant economic losses worldwide. Lesions are typically found at the volar skin proximal to the heel bulbs. Microscopic examination of biopsies or touch preparations of these lesions revealed a variety of different bacterial morphotypes including significant numbers of spirochetes which often represent the predominant morphotype. We used comparative 16S rRNA sequence analysis to determine the diversity and phylogeny of these hitherto unclassified DD spirochetes. Results indicate that those lesions looked at so far contained at least five spirochetal phylotypes, all clustering within the genus Treponema. Phylotype DDKL-4 was nearly identical (99.4% similarity) to that of a nonpathogenic human treponeme, T. phagedenis. Two phylotypes DDKL-3 and ...
Dang Thi Minh Ha, Nguyen Thi Ngoc Lan, Vo Sy Kiet, Marcel Wolbers, Hoang Thi Thanh Hang, Jeremy Day, Nguyen Quang Hien, Nguyen Anh Tien, Pham Thuy An, Truong Thi Anh, Do Thi Tuong Oanh, Chau Luong Hoa, Nguyen Thi Minh Chau, Nguyen Ngoc Hai, Ngo Thanh Binh, Le Hong Ngoc, Doan Thanh Phuong, Tran Van Quyet, Nguyen Thi Bich Tuyen, Vo Thi Ha, Nguyen Thi Nho, Dai Viet Hoa, Phan Thi Hoang Anh, Nguyen Huy Dung, Jeremy Farrar, Maxine Caws ...
A medical device for endoscopic access of a body cavity and a method of percutaneously placing inner and outer access sheaths of the device into the body cavity. The medical device includes inner and outer access sheaths and a dilator which is inserted into the outer sheath and has a shoulder or a shoulder piece for abutting against the proximal end of the outer sheath. The device also includes a wire guide that is percutaneously inserted into the body cavity via an introducer needle. The dilator and outer sheath are placed over the wire guide to dilate the puncture site and introduce the dilator and outer sheath into the body cavity. The dilator comprises an elongated cylindrical member having a passageway opening distally from the conically-shaped distal end and from an outside lateral wall of the dilator about the proximal end. The dilator also includes an end cap which is utilized to force the dilator and the outer sheath through the puncture site and into the body cavity. After positioning in the
There are no specific protocols for Recombinant Treponema Membrane Protein A (Beta-Galactosidase) (ab54101). Please download our general protocols booklet
This chapter consists of short notes, diagrams, and tables to summarize infections caused by spirochaetes. The chapter begins with a classification system to divide these organisms into Treponema, Borrelia, Leptospira, and Brachyspira. Separate sections then follow on the infections of most clinical significance for the tropics and subtropics, including leptospirosis, syphilis, non-venereal treponemes, and relapsing fevers. For ease of reference, each topic is broken down into sections, including classification, epidemiology, microbiology, pathophysiology, clinical syndromes, diagnosis, treatment and prevention.
In a similar way, we could say that Westernized humans have lost the ability to be skinny (since obesity is high in many such populations). Non human primates have such abilities and so do some non Westernized populations. But losing skinnyness does not seem quite right since we do not know exactly why obesity is higher in Westernized populations. I think it would be better in such cases to say something like do not show an ancestral trait (the ancestral trait here being skinnyness) and to not use lost until we know more about what is going on. Similarly, I think saying some human populations have lost these Spirochaetes is not quite right ...
A pneumatic massage apparatus adapted for pressotherapy includes an inflatable sleeve having inner and outer sheaths, and lateral partition walls extending between the inner and outer sheaths. The inn
Rao, X., Thapa, K. S., Chen, A. B., Lin, H., Gao, H., Reiter, J. L., Hargreaves, K. A., Ipe, J., Lai, D., Xuei, X., Wang, Y., Gu, H., Kapoor, M., Farris, S. P., Tischfield, J., Foroud, T., Goate, A. M., Skaar, T. C., Mayfield, R. D., Edenberg, H. J. & 1 others, Liu, Y., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.. Research output: Contribution to journal › Article ...
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TY - JOUR. T1 - Virulence characteristics of oral treponemes in a murine model. AU - Kesavalu, L.. AU - Walker, S. G.. AU - Holt, S. C.. AU - Crawley, R. R.. AU - Ebersole, J. L.. N1 - Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 1997. Y1 - 1997. N2 - This study was designed to investigate the virulence characteristics of Treponema denticola, T. socranskii, T. pectinovorum, and T. vincentii following challenge infection of mice. These microorganisms induced well- demarcated, dose-dependent, raised subcutaneous (s.c.) abscesses which were similar in time of onset, lesion progression, and duration of healing. Only viable cells were capable of inducing these characteristic s.c. abscesses. Histological examination of the skin lesion 3 and 5 days postinfection revealed abscess formation in the s.c. tissues, and abundant spiral organisms were demonstrated to be present in the abscess. Host resistance modulation by dexamethasone (neutrophil alteration) and cyclophosphamide ...
Acute necrotizing ulcerative gingivitis (ANUG; colloquially known as trench mouth) is a common, non-contagious infection of the gums with sudden onset. The main features are painful, bleeding gums, and ulceration of inter-dental papillae (the sections of gum between adjacent teeth). This disease, along with necrotizing (ulcerative) periodontitis (NP or NUP) is classified as a necrotizing periodontal disease, one of the seven general types of periodontitis. The often severe gingival pain that characterizes ANUG distinguishes it from the more common chronic periodontitis which is rarely painful. ANUG is the acute presentation of necrotizing ulcerative gingivitis (NUG), which is the usual course the disease takes. If improperly treated or neglected, NUG may become chronic and/or recurrent. The causative organisms are mostly anaerobic bacteria, particularly Fusobacteria and spirochete species. Predisposing factors include poor oral hygiene, smoking, malnutrition, psychological stress and ...
The common differential diagnosis of acute necrotizing ulcerative gingivitis may inlcude traumatic injury, infections and malignancies. The risk factors of developing acute necrotizing ulcerative gingivitis may include HIV/ AIDS, poor oral hygiene, alco
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Bovine digital dermatitis (BDD) is a serious infectious inflammatory lameness causing pain and suffering to many cattle worldwide and which has severe economic implications. This study set out to investigate relationships between the treponemes considered causal of BDD and the local inflammatory response of the bovine host. Here we describe, for the first time, the isolation of bovine foot skin keratinocytes and fibroblasts as separate cell lineages. These cell lines were then exposed to treponeme whole-cell sonicates, and the gene expression of selected host inflammatory mediators investigated using quantitative reverse transcriptase PCR. Several genes, including those encoding RANTES/CCL5, MMP12, TNFα, TGFβ and TIMP3 were significantly upregulated in fibroblasts exposed to whole-cell sonicates derived from BDD treponeme phylotypes. For each of the above genes there were similar fibroblast expression increases for all three BDD treponeme phylotypes tested, suggesting common virulence ...
Digital dermatitis (DD) is an infectious foot disease causing severe lameness in dairy cattle (worldwide) and sheep (UK). This study investigated whether DD Treponema phylogroups can be present on equipment used to trim ruminant hooves and, therefore, consider this trimming equipment as a possible vector for the transmission of DD. Equipment was tested after being used to trim DD symptomatic and asymptomatic cattle and sheep hooves, and subsequently after disinfection of equipment. After trimming, Treponema medium/Treponema vincentii-like, Treponema phagedenis-like and Treponema denticola/T putidum-like DD spirochaetes, were shown to be present on 23/37 (62%), 21/37 (57%) and 20/37 (54%) of knives, respectively. After disinfection, detection rates for the DD treponemes were 9/37 (24%), 6/37 (16%) and 3/37 (8%), respectively. Following culture of a swab, an isolate belonging to the T phagedenis-like spirochaetes was identified from a knife sample after trimming a DD positive cow. No ...
TY - JOUR. T1 - Sensitivity and specificity of monoclonal antibodies directed against antigenic determinants of Treponema pallidum nichols in the diagnosis of syphilis. AU - Norgard, M. V.. AU - Selland, C. K.. AU - Kettman, J. R.. AU - Miller, J. N.. PY - 1984/1/1. Y1 - 1984/1/1. N2 - Murine anti-Treponema pallidum monoclonal antibodies were employed in studies on sensitivity and specificity of binding to examine their potential for use in the detection of low numbers of pathogenic treponemes present in various body fluids. Monoclonal antibodies were used as a primary antibody source in a solid-phase immunoblot assay system. All monoclonal antibodies assayed were capable of detecting ca. 1.0 x 103 to 2.5 x 103 treponemes. Of 13 monoclonal antibodies examined, 3 were able to detect 103 virulent treponemes, and 1 of these antibodies was able to reveal the presence of as few as 500 organisms. Western blot analyses showed that all anti-T. pallidum monoclonal antibodies exhibiting high sensitivities ...
J Periodontol. 1986 Mar;57(3):141-50. Acute necrotizing ulcerative gingivitis. A review of diagnosis, etiology and treatment. Johnson BD, Engel D. ...
Learn more about Acute Necrotizing Ulcerative Gingivitis at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Acute Necrotizing Ulcerative Gingivitis at Memorial Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Parit mulut adalah bentuk parah yang menyebabkan radang gusi menyakitkan, infeksi, pendarahan gusi dan ulcerations. Penyakit ini biasa terjadi di negara-negara berkembang dengan gizi buruk dan kondisi kehidupan masyarakat miskin. Parit mulut secara resmi dikenal sebagai acute necrotizing ulcerative gingivitis (ANUG). Nama Palung Mulut karena kejadian di kalangan tentara yang terjebak di parit perlindungan selama Perang Dunia I tanpa sarana untuk merawat gigi dengan benar.. PENYEBAB. Penyebab yang paling memungkinkan adanya parit mulut adalah bakteri berbahaya dalam mulut. Bakteri tersebut mengeluarkan racun yang dapat mengiritasi gusi dan menyebabkan infeksi lebih lanjut. Jika tidak diobati, infeksi tersebut akan menjadi bisul yang menyebabkan kerusakan jaringan yang melemahkan gigi.. GEJALA. ...
Whole cells of T. hyodysenteriae serotypes 1-7, avirulent T. hyodysenteriae serotypes 1 and 2, and 5 strains of T. innocens were chemically extracted to selectively remove a lipopolysaccharide-like substance (LPSLS). The different LPSLS were analyzed electrophoretically, immunologically, and chemically. SDS-PAGE demonstrated migratory differences that were unique for individual serotypes/strains. Additional differences were observed during attenuation which resulted in reduced mobility of upper molecular weight components. Western blotting with hyper-immunized rabbit serum (HRS) against serotype 1, 2, and 6 whole cell bacterins produced homologous and heterologous reactions with serotype specific LPSLS. Rabbit antisera to serotypes 3, 4, 5, and 7 whole cell bacterins produced only homologous reaction to the LPSLS. Convalescent-phase swine sera (CSS) against serotype 1 disease showed only homologous reaction to the LPSLS. Convalescent-phase swine sera against serotype 2 produced both homologous ...
Periodontitis is a chronic inflammatory disease that affects over 116 million adults in the United States. A shift in the normal microflora occurs as periodontal disease develops resulting in a larger number of Gram-negative anaerobes and spirochetes. An increase in the oral spirochete, Treponema denticola, is highly correlated with periodontal disease progression and severity. The ability of this periopathogen to thrive in the subgingival crevice is dependent on complement evasion mechanisms. Earlier analyses demonstrated that the primary mechanism of T. denticola serum resistance is binding of the human complement regulatory protein, Factor H (FH), to the factor H-binding protein (FhbB). FH serves as cofactor in the Factor-I mediated cleavage of C3b and accelerates the decay of the C3 convertase complex, leading to downregulation of C3b production. Several pathogens bind FH, and a number of these bacterial binding proteins have been shown to bind plasminogen. Plasminogen is a plasma
Definition : Microbiology reagents intended to identify Treponema pallidum, a bacterium of the family Spirochaetaceae. Treponema pallidum bacteria are the etiologic agent of syphilis, a disease transmitted sexually or acquired in utero.. Entry Terms : Reagents, Microbiology, Bacteria, Identification, Syphilis , Treponema Species Detection/Identification Reagents , Treponema pallidum Reagents, Identification/Detection , Treponema pallidum Detection/Identification Reagents , Treponema pallidum Bacteria Identification/Detection Reagents , Syphilis Reagents, Identification , Syphilis Diagnostic Reagents , Reagents, Sexually Transmitted Disease , Reagents, Microbiology, Bacteria, Identification, Treponema pallidum. UMDC code : 19206 ...
N2 - DNA microarray technology was utilized to study gene expression by the syphilis spirochete Treponema pallidum subsp. pallidum (Nichols) isolated from rabbit testes 10 days post infection. Microarrays containing all 1039 annotated ORFs of Treponema pallidum subspecies pallidum (Nichols) were printed on glass slides. For 1034 ORFs (out of 1039), signals higher than the threshold (average of negative control spots + 3 SDs) were detected for both RNA and DNA probes. The most highly transcribed genes were found to correlate with the most conspicuous spots identified by two dimensional gel electrophoresis, indicating that the transcript levels generally corresponded to the relative protein concentrations. Genes with high transcript concentrations included those encoding flagellar filament and cytoplasmic filament proteins, prominent lipoproteins and membrane proteins, chaperonins, proteins involved in red-ox balance, chemotaxis regulatory proteins, a V-ATPase operon, and certain metabolic enzymes ...
Definition of Treponema pertenue. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Treponemes have a helical or sinusoidal shape and a double membrane. The spirochaete has two flagella that originate at either end of the organism and point inward along its length, and are contained in the periplasmic space between the inner and outer membranes and enable them to move. Treponemes are able to use carbohydrates as their only source of energy. They are unable to synthesize fatty acids, enzyme cofactors, and most amino acids, and are dependent on their host for their acquisition. Treponema pallidum has been called a metabolic basket case due to its absolute dependence on its host. Thus far, researchers have been unable to culture the bacterium in vitro. It is supposed that this failure results from the absence of one or more vital nutrients from the medium, due to the bacteriums complex, and as yet, unknown, nutritional requirements. Treponema pallidum has been termed a stealth pathogen because of its lack of surface proteins. Beacause of this lack of proteins, creating a ...
Treponema pallidum p15, 0.5 mg. |p class=db_paraghraph|Treponema pallidum is a gram-negative spirochaete bacterium and is considered to be metabolically crippled.
Lipids of Treponema pallidum Kazan 5: The lipid composition of Treponema pallidum Kazan 5 cultivated in a lipid-defined medium was investigated. Lipids comprise
Treponema pallidum ELISA Kit (Colorimetric). High sensitivity ELISA kit for detection of Treponema pallidum. Backed by our 100% Guarantee.
The present invention is directed to an ultrasonic surgical instrument including an improved outer sheath which is removable and which rotateably engages the ultrasonic waveguide to facilitate attachment of the ultrasonic instrument to a handpiece. In particular, in one embodiment of the present invention, an improved sheath includes a first and second sheath pin slots extending from the proximal end of the sheath to first and second sheath pinholes respectively. An ultrasonic surgical instrument according to the present invention further includes a connector pin, the connector pin extending through the first sheath pinhole, a waveguide pinhole and the second sheath pinhole and an attachment hub surrounding the outer sheath, wherein the attachment hub is slideable over the outer sheath. A first pin slot may be positioned on an inner surface of the attachment hub wherein the connector pin engages the first pin slot when the attachment hub is in its proximal most position.
A 21-year-old man presented to the emergency department with a 6-hour history of vomiting, epigastric pain and diarrhea after uncooked seafood consumption. He had no documented medical history. Physical examination revealed normal vital signs and mild epigastric tenderness with hypoactive bowel sounds. The rest of the physical exam was unremarkable.
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Learn about the causes, symptoms, diagnosis & treatment of Periodontal Disorders from the Professional Version of the Merck Manuals.
BioAssay record AID 205190 submitted by ChEMBL: In vitro antibacterial activity against Serpulina (Treponema) hyodysenteriae was tested and is expressed as minimum inhibitory concentration: Value ranges from (50-100 ug/mL).
The phylogenetically divergent spirochete bacterium Treponema pallidum subsp. pallidum is the causative agent of syphilis. Central to the capacity of T. pallidum to establish infection is the ability of the pathogen to attach to a diversity of host cells. Many pathogenic bacteria employ leucine-rich repeat (LRR) domain-containing proteins to mediate protein - protein interactions, inc...
Lectures mycoplasma,ureaplasma spirochetes-borrelia, leptospira,treponema chlamydia, rickettsia Mycobacterium att. Spirochetales Genus : TREPONEMA, BORRELIA, LEPTOSPIRA, Slideshow 5745602 by jarah
Spirochaete Spirochaetes Treponema pallidum spirochetes. Scientific classification Domain: Bacteria Phylum: Spirochetes Class: Spirochetes Order:
Samples of serum and testicular fluid from normal rabbits and those infected with Treponema pallidum were examined for total protein, albumin, IgG, and IgM concentrations. Total protein concentrations were similar in testicular fluid from normal and infected animals but were lower than in serum. The concentrations of individual proteins in serum did not differ substantially between infected and non-infected rabbits. In testicular fluid, however, the concentrations of all three proteins, especially IgM, were greater in infected rabbits. A significantly (p less than 0.02) raised testis-IgM index, together with a higher concentration of anti-treponemal IgM in the infected testicular fluid than in autologous serum, suggests local synthesis of IgM antibodies.. ...
Alzheimers disease (AD) is associated with dementia, brain atrophy and the aggregation and accumulation of a cortical amyloid-beta peptide (Abeta). Chronic bacterial infections are frequently associated with amyloid deposition. It had been known from a century that the spirochete Treponema pallidum can cause dementia in the atrophic form of general paresis. It is noteworthy that the pathological hallmarks of this atrophic form are similar to those of AD. Recent observations showed that bacteria, including spirochetes contain amyloidogenic proteins and also that Abeta deposition and tau phosphorylation can be induced in or in vivo following exposure to bacteria or LPS. Bacteria or their poorly degradable debris are powerful inflammatory cytokine inducers, activate complement, affect vascular permeability, generate nitric oxide and free radicals, induce apoptosis and are amyloidogenic. All these processes are involved in the pathogenesis of AD. Old and new observations, reviewed here, indicate ...
References for Abcams Recombinant Treponema pallidum p41 protein (ab68123). Please let us know if you have used this product in your publication
Enzyme immunoassay for the detection of IgG antibodies to Treponema pallidum in human serum or plasma. SmartEIA kit is specifically designed for automated analysis using the Agility instrument.
UK 69753 is a member of the efrotomycin family of antibiotics and has shown to have potent activity both in vitro and in vivo against the swine pathogen Treponema hyodysenteriae.
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR ...
We recently reported a flavin‐trafficking protein (Ftp) in the syphilis spirochete Treponema pallidum (Ftp_Tp) as the first… Expand ...
The identification of molecules important in syphilis pathogenesis and in protective immunity is critical for understanding the mechanisms by which T. pallidum is able to cause a multistage disease and to establish life-long infection. In this study, we demonstrate that T. pallidum has a polymorphic, multicopy gene family that codes for proteins homologous to the msp of T. denticola. The T. pallidum tpr gene family represents 2% of the organisms total DNA content, a striking proportion in an organism with an unusually small genome (1.1 Mb). The devotion of this proportion of DNA to a gene family, in an organism that has killed numerous metabolic genes during evolution, suggests that the Tpr proteins may play a critical role in T. pallidum survival and virulence.. Several lines of evidence support the hypothesis that at least some of the T. pallidum Tpr proteins are located in the outer membrane with surface-exposed variable domains. First, the paralogous msp protein of T. denticola is surface ...
SWISS-MODEL Repository entry for Q73K75 (RS2_TREDE), 30S ribosomal protein S2. Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
SWISS-MODEL Repository entry for Q73NR2 (SYT_TREDE), Threonine--tRNA ligase. Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
An implantable active fixation lead includes an outer sheath, a protector member having a peripheral surface extending between its distal and proximal end surfaces with a helical groove formed in the peripheral surface, and a fixation helix integral with the outer sheath. The fixation helix includes a tip end engageable with body tissue and slidably engaged with the helical groove for relative translation and rotation. A longitudinal force on the lead firmly engages the protector members distal end surface with the body tissue. With the fixation helix initially retracted proximally of the protector members distal end surface and disengaged from the body tissue, upon application of torque to the outer sheath, the distal end surface of the protector member is moved proximally with respect to the fixation helix which, simultaneously, is extended distally beyond the distal end surface of the protector member to an extended position into engagement with the body tissue.
We can supply customers across the globe. If your country or region is not in the list below dont worry. Contact us on [email protected] and we will put you in touch with your nearest distributor.. ...
4IG1: The TP0796 Lipoprotein of Treponema pallidum Is a Bimetal-dependent FAD Pyrophosphatase with a Potential Role in Flavin Homeostasis.
4IG1: The TP0796 Lipoprotein of Treponema pallidum Is a Bimetal-dependent FAD Pyrophosphatase with a Potential Role in Flavin Homeostasis.
Treponema denticola • Trigeminal ganglion • Trismus • Tuftelin • Tufts University School of Dental Medicine • Turner's ...
Treponema spp. Porphyromonas gingivalis Fusobacterium nucleatum is found between the early and late colonisers, linking them ...
Syphilis (Treponema pallidum). Bennett J, Dolin R, Blaser M, eds. Mandell, Douglas, and Bennett's Principles and Practice of ... The CSF is tested for antibodies for specific Treponema pallidum antigens. The preferred test is the VDRL test, which is ... Within days to weeks after initial infection, Treponema pallidum disseminates via blood and lymphatics. The organism may ...
Klingmüller, G (December 1983). "[Treponema pallidum or Spirochaeta pallida?]". Der Hautarzt; Zeitschrift für Dermatologie, ... also known as Treponema pallidum). The work was carried out at the Berlin Charité. Among Schaudinn's other contributions to ...
The causative organism, Treponema pallidum, was first identified by Fritz Schaudinn and Erich Hoffmann, in 1905. The first ... 2006). Pathogenic Treponema: Molecular and Cellular Biology. Caister Academic Press. ISBN 978-1-904455-10-3. Alexander, JM; ... Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The signs and ... Three other human diseases are caused by related Treponema pallidum subspecies, including yaws (subspecies pertenue), pinta ( ...
Sometimes tonsillitis is caused by an infection of spirochaeta and treponema, which is called Vincent's angina or Plaut-Vincent ... Treponema pallidum, and Neisseria gonorrhoeae. Anaerobic bacteria have been implicated in tonsillitis, and a possible role in ...
1932). "Modified silver stain for Treponema pallidum". American Journal of Clinical Pathology. 2, 63. de Galantha, E. (1935). " ... 1932). "Modified silver stain for Treponema pallidum". American Journal of Clinical Pathology. 2, 63. de Galantha, E. (1935). " ...
"The binary protein interactome of Treponema pallidum--the syphilis spirochete". PLOS One. 3 (5): e2292. doi:10.1371/journal. ... "Genome scale identification of Treponema pallidum antigens". Infection and Immunity. 73 (7): 4445-4450. doi:10.1128/IAI.73.7. ...
Treponema pallidum pertenue), bejel (Treponema pallidum endemicum), and pinta (Treponema carateum). Haemophilus ducreyi ... All other Treponema pallidum subspecies probably evolved from Treponema pallidum pertenue. Yaws is believed to have originated ... The genetic analysis of the yaws causative bacteria-Treponema pallidum pertenue-has led to the conclusion that yaws is the most ... Yaws is a tropical infection of the skin, bones, and joints caused by the spirochete bacterium Treponema pallidum pertenue. The ...
Pinta is caused by the bacterium Treponema carateum. It is related to the more well-known T. pallidum, which can cause endemic ... Treponema carateum, which is morphologically and serologically indistinguishable from the bacterium that causes syphilis. The ...
Meuric V, Martin B, Guyodo H, Rouillon A, Tamanai-Shacoori Z, Barloy-Hubler F, Bonnaure-Mallet M (February 2013). "Treponema ... 2010). "Porphyromonas gingivalis and Treponema denticola Mixed Microbial Infection in a Rat Model of Periodontal Disease". ... gingivalis and Treponema denticola. The role of P. gingivalis in periodontitis is studied using specific pathogen-free mouse ...
Treponema pallidum troR, a metal-dependent transcriptional repressor. Archaeoglobus fulgidus MDR1 (troR), a metal-dependent ...
The causative organism, Treponema pallidum, was first identified by Fritz Schaudinn and Erich Hoffmann in 1905. The first ... In 1905, Schaudinn and Hoffmann discovered Treponema pallidum in tissue of patients with syphilis. One year later, the first ... Mulligan CJ, Norris SJ, Lukehart SA (2008). "Molecular studies in Treponema pallidum evolution: toward clarity?". PLOS ... associating Treponema pallidum with neurosyphilis. Prior to Noguchi's discovery, syphilis had been a burden to humanity in many ...
Syphilis is a sexually transmitted disease that is brought upon by the gram negative bacteria, Treponema pallidum. Treponema ... VDRL and TPHA (Treponema pallidum haemagglutination) are positive[2]. Prevention[edit]. There are many different forms on ... Treponema pallidum invades the nervous system within three to eighteen months after the primary infection. The initial series ... Treponema pallidum, which is a spirochate bacterium, is the main cause of syphilis, which spreads drastically throughout the ...
Main article: Treponema pallidum. Treponema pallidum subspecies pallidum is a spiral-shaped, Gram-negative, highly mobile ... 2006). Pathogenic Treponema: Molecular and Cellular Biology. Caister Academic Press. ISBN 978-1-904455-10-3. .. ... Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum.[3] The signs and ... The causative organism, Treponema pallidum, was first identified by Fritz Schaudinn and Erich Hoffmann, in 1905.[86] The first ...
"The Binary Protein Interactome of Treponema pallidum - the Syphilis Spirochete". PLoS ONE. 3 (5): e2292. Bibcode:2008PLoSO... ...
TIGR sequenced the genome of Treponema pallidum (which causes syphilis). In 1999 TIGR published the sequence of the ... "Complete genome sequence of Treponema pallidum, the syphilis spirochete". Science. 281 (5375): 375-388. Bibcode:1998Sci...281.. ...
Anais Brasileiros de Dermatologia The Discovery of Treponema pallidum. ... a spiral-shaped spirochete called Treponema pallidum. The organism was removed from a papula in the vulva of a patient with ...
2015] Genus Treponema Schaudinn 1905 emend Abt et al. 2013 ["Spironema" Vuillemin 1905 non-Klebs 1892; "Microspironema" Stiles ... Prokaryote Treponema pallidum Brevinema andersonii Syphilis Yaws spirochaete - Oxford Dictionaries Elsevier, Dorland's ... which causes relapsing fever Treponema pallidum subspecies which cause treponematoses such as syphilis and yaws. Brachyspira ...
Treponema denticola‎; 06:29 . . (-249)‎ . . ‎. Boghog. (talk , contribs)‎ (consistent citation formatting). *(diff , hist) . . ... m Treponema denticola‎; 22:13 . . (+377)‎ . . ‎. ScienceGlee. (talk , contribs)‎ (Added the original reference linking quantity ... Treponema denticola‎; 22:57 . . (+2,545)‎ . . ‎. ScienceGlee. (talk , contribs)‎ (Created a paragraph on the unique cell ...
m Treponema denticola‎; 14:05 . . (+15)‎ . . ‎. Tom.Reding. (talk , contribs)‎ (Add from=Q2534751 to {{Taxonbar}}; WP:GenFixes ...
1998). "Complete genome sequence of Treponema pallidum, the syphilis spirochete". Science. 281 (5375): 375-388. Bibcode:1998Sci ...
2004). "Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes". Proc. Natl. Acad. Sci ... 1998). "Complete genome sequence of Treponema pallidum, the syphilis spirochete". Science. 281 (5375): 375-88. Bibcode:1998Sci ...
In 1905 the cause of syphilis (Treponema pallidum) was identified. In the following year the Wassermann test for identification ...
"The binary protein interactome of Treponema pallidum--the syphilis spirochete". PLOS ONE. 3 (5): e2292. doi:10.1371/journal. ...
Izard J, Sasaki H, Kent R (2012). "Pathogenicity of Treponema denticola Wild-Type and Mutant Strain Tested by an Active Mode of ... Murphy GE, Matson EG, Leadbetter JR, Berg HC, Jensen GJ (March 2008). "Novel ultrastructures of Treponema primitia and their ... Izard J, Hsieh CE, Limberger RJ, Mannella CA, Marko M (July 2008). "Native cellular architecture of Treponema denticola ... Izard J (2006). "Cytoskeletal cytoplasmic filament ribbon of Treponema: a member of an intermediate-like filament protein ...
Digital dermatitis is caused by the bacteria from the genus Treponema. It differs from foot rot and can appear under unsanitary ...
Izard J, Hsieh CE, Limberger RJ, Mannella CA, Marko M (July 2008). "Native cellular architecture of Treponema denticola ... "Cryo-electron tomography elucidates the molecular architecture of Treponema pallidum, the syphilis spirochete". Journal of ...
Treponema pallidum, the cause of syphilis, is spread by sexual activity. Viruses are obligate intracellular parasites, ...
2009 Treponema porcinum Nordhoff et al. 2005 Treponema primitia Graber et al. 2004 Treponema putidum Wyss et al. 2004 Treponema ... 2006 ?Treponema calligyrum ♠ Noguchi ?Treponema carateum ♥ (pinta-causing Treponema) ?Treponema minutum ♦ Dobell 1912 ? ... Treponema vincentii ♠ Smibert 1984 ?Treponema zioleckii ♠ Piknova et al. 2008 Treponema amylovorum Wyss et al. 1997 Treponema ... 2008 Treponema lecithinolyticum Wyss et al. 1999 Treponema maltophilum Wyss et al. 1996 Treponema medium ♦ Umemoto et al. 1997 ...
Treponema carateum is a species of spirochete bacteria in the genus Treponema. It is the cause of pinta, a disease affecting ...
Treponema (family Spirochaetaceae, order Spirochaetales [1])* A genus of flexible, spirally shaped bacteria [2] which are ... Treponema (trep-ŏ-nee-mă) n. a genus of anaerobic spirochaete bacteria. All species are parasitic; some cause disease, such as ... Treponema (family Spirochaetaceae, order Spirochaetales) A genus of flexible, spirally shaped bacteria which are anaerobic or ... MICHAEL ALLABY "Treponema ." A Dictionary of Plant Sciences. . Encyclopedia.com. 25 Feb. 2021 ,https://www.encyclopedia.com,. ...
Darkfield micrograph of Treponema pallidum.
CDCs Division of STD Prevention is making available a Treponema pallidum subspecies pallidum (T. pallidum) strain propagated ...
Definition of Treponema pertenue. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... Treponema pertenue. Definition: a bacterial species that causes yaws; patients with this disease give positive results in ...
Treponema pertenue definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ... treponema pertenue in Medicine Expand. Treponema pertenue Treponema per·ten·u·e (pər-těnyōō-ē). n. A spirochete that causes ...
Treponema pallidum definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ... treponema pallidum in Medicine Expand. Treponema pallidum Treponema pal·li·dum (pālĭ-dəm). n. A spirochete that causes ... This disease is caused by a microorganism known as the spirochaeta pallida or treponema pallidum of Schaudinn and Hoffmann. ...
Definition of treponema-immobilizing antibody. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms ... treponema-immobilizing antibody. Definition: antibody, evoked during syphilitic infections, possessing specific affinity for ... Treponema pallidum; in the presence of complement immobilizes the organism.. Synonym(s): immobilizing antibody, treponemal ...
Columbus and Treponema Pallidum. October 7th, 2005 Nicholas Genes the good old days... ...
Detection of Treponema denticola in Atherosclerotic Lesions Katsuji Okuda, Kazuyuki Ishihara, Taneaki Nakagawa, Akihiko ... rpoB Gene Analysis as a Novel Strategy for Identification of Spirochetes from the Genera Borrelia,Treponema, and Leptospira ... Identification of a Novel, Invasive, Not-Yet-Cultivated Treponema sp. in the Large Intestine of Pigs by PCR Amplification of ... Of the 44 oral samples cultivated, 15 (34%) were found to be positive for Treponema using electron microscopy and were also ...
"Treponema". LPSN.. *^ a b c d Chan EC, McLaughlin R (February 2000). "Taxonomy and virulence of oral spirochetes". Oral ... It is one of four species of oral spirochetes to be reliably cultured, the others being Treponema pectinovorum, Treponema ... Treponema Denticola is one of three bacteria that form the Red Complex, the other two being Porphyromonas gingivalis and ... Treponema Denticola is a potential etiological bacterial agent for oral cancer.[19] It encourages oncogenesis (process in which ...
... GMUS-PD-0590 $9.95 ... All about Pox - Syphilis (Treponema pallidum). FACTS: The pox (or Great Pox, as distinguished from the "lesser" poxes such as ... Syphilis is caused by spiral-shaped bacteria called Treponema pallidum. It can be passed from person-to-person during ...
... Scientific classification Kingdom: Eubacteria Phylum: Spirochaetes Class: Spirochaetes ... Treponema denticola levels in the mouth are elevated in patients with periodontal diseases and the species is considered one of ... Treponema denticola is a motile and highly proteolytic bacterium. The Gram-negative oral spirochete is associated with the ... T. denticola is related to the syphilis-causing obligate human pathogen, Treponema pallidum subsp. pallidum. ...
Treponema pallidum, T. pertenue, T. carateum Description and Significance. Treponema pallidum is the causative agent of ... "Treponema berlinense sp. nov. and Treponema porcinum sp. nov., novel spirochaetes isolated from porcine faeces. International ... Weill Medical College of Cornell University: Syphilis-Treponema pallidum. *Family Practice Notebook: Syphilis, Treponema ... for which the names Treponema berlinense sp. nov. and Treponema porcinum sp. nov. are proposed." To learn more about this, ...
tr,O85748,O85748_TREDN CheW OS=Treponema denticola OX=158 GN=cheW PE=4 SV=1 ...
... that the infection of the fetus occurs during the secondary stage of syphilis when there is the highest frequency of Treponema ...
Characterization of a manganese-dependent regulatory protein, TroR, from Treponema pallidum. James E. Posey, John M. Hardham, ... Characterization of a manganese-dependent regulatory protein, TroR, from Treponema pallidum. James E. Posey, John M. Hardham, ... Characterization of a manganese-dependent regulatory protein, TroR, from Treponema pallidum. James E. Posey, John M. Hardham, ... The lack of in vitro culture techniques and genetic systems for Treponema pallidum has made it extremely difficult to identify ...
Inflammation and immune evasion coexist in Treponema pallidum-infected skin.. Trujillo R1, Cervantes J2, Hawley KL1,3, Cruz AR4 ... IF, immunofluorescence; SS, secondary syphilis; Treponema pallidum; penicillin; secondary syphilis; sexually transmitted ...
Syphilis is a chronic disease caused by the bacterium Treponema pallidum subsp. pallidum. Treponema pallidum disseminates ... Syphilis is a chronic disease caused by the bacterium Treponema pallidum subsp. pallidum. Treponema pallidum disseminates ... Treponema pallidum subsp. pallidum str. Nichols. Mutation(s): 1 Gene Names: TP_0751. ... The Structure of Treponema pallidum Tp0751 (Pallilysin) Reveals a Non-canonical Lipocalin Fold That Mediates Adhesion to ...
Treponema pallidum particle agglutination assay (TPPA)is used in addition to other tests in order to confirm the presence of ... In other words, as long as the treponema are whole they are nonantigenic. The outer membrane proteins of T. pallidum are rare ... Treponema pallidum is a motile, spirochaete bacterium that has subspecies that can cause treponemal diseases such as syphilis, ... Treponema has three proteins with fibronectin adhesion molecules. The three molecules are named for where they were discovered ...
Treponema, Oxitocina, Toxoplasma gondii, Estrés, Machos, Glassër. In: Antibioterapia práctica - Suis - N°129, Jul.-Ago. 2016 by ...
Homologous recombination - Treponema denticola [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show ...
Methane metabolism - Treponema paraluiscuniculi [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show ...
The following line item shows treponema pallidum antibodies: ... ... Forums>STDs>Syphilis: RPR reactive, but negative for treponema ... The following line item shows treponema pallidum antibodies: negative. Im wondering if this means that the RPR is a false ... 1. What is the probability of an RPR false positive here? If the treponema pallidum antibodies show negative, is that a ... When person have syphilis, they develop positive treponema pallidum antibody tests BEFORE they develop a positive RPR. False ...
Treponema. Schaudinn 1905. Treponema generoa bakterio Gram negatiboz osatuta dago, Spirochaetaceae familia barnean sailkatuta ... Treponema guztiak anaerobioak dira edo, asko jota, mikroaerofiloak.. Treponema gehienek eskakizun nutritibo zorrotzak dituzte, ... Espezie patogenoen artean Treponema pallidum -sifiliaren eragilea- eta Treponema carateum dira aipagarrienak. Ez-kaltegarrien ... Espezie patogeno batzuk (Treponema pallidum, kasu) ezin dira laborategian kultibatu.. Datu-base taxonomikoak. EOL GBIF ITIS ...
Rabbit polyclonal Treponema pallidum antibody conjugated to HRP. Validated in WB, ELISA. Immunogen corresponding to tissue, ... Treponema pallidum is the causative agent of syphilis. It is a gram negative spirochete, a helical to sinusoidal bacterium with ... This antibody reacts with Treponema pallidum in bacterial and infected tissue samples. ...
References for Abcams Recombinant Treponema pallidum p41 protein (ab68123). Please let us know if you have used this product ...
STUDIES ON TREPONEMA PALLIDUM AND SYPHILIS. Hans Zinsser, J. G. Hopkins, Malcolm McBurney ... 1. Immune sera produced in rabbits by treatment with our Culture Strain A of Treponema pallidum agglutinated not only the ...
  • 1995) Abt, Göker & Klenk 2013 Treponema denticola (ex Flügge 1886) Chan et al. (wikipedia.org)
  • Treponema denticola is a Gram-negative , obligate anaerobic , motile and highly proteolytic spirochete bacterium. (wikipedia.org)
  • Treponema Denticola is one of three bacteria that form the Red Complex, the other two being Porphyromonas gingivalis and Tannerella forsythia . (wikipedia.org)
  • [4] [5] T. denticola is related to the syphilis-causing obligate human pathogen, Treponema pallidum subsp. (wikipedia.org)
  • [2] Spirochetes , including Treponema denticola , are therefore able to navigate through particularly viscous environments, unlike that of other prokaryotes. (wikipedia.org)
  • [16] Treponema denticola , a subgingival oral spirochete has been associated with many periodontal disease conditions such as: the early stage of periodontitis, acute pericoronitis (infection under the gum tissue covering a partially erupted tooth) 3 , as well as necrotising ulcerative gingivitis (severe inflammation of the gum more common in immunocompromised patients). (wikipedia.org)
  • Clinical evidence and research shows that periodontal pockets contain large numbers of treponema denticola together with other proteolytic gram negative bacteria , playing an important role in the development of periodontal disease . (wikipedia.org)
  • The toxic products of these bacteria, especially treponema denticola may damage the surface lining periodontal cells making them more prone to damage as well as lysis. (wikipedia.org)
  • Treponema denticola attaches to fibroblasts and epithelial cells as well as to extracellular matrix components which are found in periodontal tissues and release its own bacterial contents. (wikipedia.org)
  • Treponema denticola levels in the mouth are elevated in patients with periodontal diseases and the species is considered one of the main etiological agents of periodontitis . (bionity.com)
  • The Molecular Biology of the Survival and Virulence of Treponema denticola", Molecular Oral Microbiology . (bionity.com)
  • It uses material from the Wikipedia article "Treponema_denticola" . (bionity.com)
  • Treponema denticola eta Treponema oralis . (wikipedia.org)
  • Treponema denticola ( Td ) is associated with severe periodontitis, a chronic inflammatory disease leading to tooth loss. (nature.com)
  • In the oral microbiome, the so-called periodontopathogens, including Fusobacterium nucleatum ( Fn ), Porphyromonas gingivalis ( Pg ), Treponema denticola ( Td ), Aggregatibacter actinomycetemcomitans ( Aa ), and Tannerella forsythia ( Tf ) have been receiving increasing interest in the context of cancer aetiology. (nature.com)
  • Arginine catabolism by Treponema denticola. (currentprotocols.com)
  • Gene inactivation in the oral spirochete Treponema denticola: construction of an flgE mutant. (asm.org)
  • Treponema denticola is implicated in the etiology of periodontal diseases. (asm.org)
  • We have addressed this problem by determining the structure of a second DGR variable protein, TvpA, from the pathogenic oral spirochete Treponema denticola. (osti.gov)
  • Treponema denticola and certain other oral Treponema species that are associated with human periodontal disease are cultivable, opportunistic pathogens ( 22 ). (asm.org)
  • Both approaches led to the identification of a polymorphic multicopy gene family with predicted amino acid homology to the major sheath protein of Treponema denticola . (rupress.org)
  • In this report we describe the identification of a multicopy polymorphic gene family of T . pallidum , termed T . pallidum repeat ( tpr ), 1 that is related to the major surface protein (msp) genes of Treponema denticola . (rupress.org)
  • Bacterial synergy of Treponema denticola and Porphyromonas gingivalis in a multinational population. (semanticscholar.org)
  • Treponema denticola and Porphyromonas gingivalis have been associated with human adult severe periodontitis. (semanticscholar.org)
  • Tip-oriented adherence of Treponema denticola to fibronectin. (mysciencework.com)
  • The adherence of Treponema denticola to ligands on cell surfaces or in basement membranes of periodontal tissues might play an important role in its pathogenicity. (mysciencework.com)
  • Treponema pallidum subsp. (rcsb.org)
  • Syphilis is a chronic disease caused by the bacterium Treponema pallidum subsp. (rcsb.org)
  • In 1905, microbiologist Fritz Richard Schaudinn and dermatologist Paul Erich Hoffmann described Treponema pallidum subsp. (cdc.gov)
  • Long-term in vitro culture of the syphilis spirochete Treponema pallidum subsp. (cdc.gov)
  • N2 - DNA microarray technology was utilized to study gene expression by the syphilis spirochete Treponema pallidum subsp. (muni.cz)
  • The phylogenetically divergent spirochete bacterium Treponema pallidum subsp. (medworm.com)
  • Molecular characterization of Treponema pallidum subsp. (plos.org)
  • Syphilis, caused by the spirochete Treponema pallidum subsp. (muni.cz)
  • Sequence Variation of Rare Outer Membrane Protein beta-Barrel Domains in Clinical Strains Provides Insights into the Evolution of Treponema pallidum subsp. (muni.cz)
  • The major treponeme species of human pathogens is Treponema pallidum , whose subspecies are responsible for diseases such as syphilis , bejel , and yaws . (wikipedia.org)
  • The species Treponema hyodysenteriae and Treponema innocens have been reclassified into Serpulina hyodysenteriae and Serpulina innocens . (wikipedia.org)
  • Treponema carateum is a species of spirochete bacteria in the genus Treponema. (wikipedia.org)
  • We present here a new passive-filtration-based culture device combined with rapid identification with a new electron microscope (Hitachi TM4000) for the detection and culture of Treponema species from the human oral cavity. (asm.org)
  • The study concluded that "based on their phenotypic and genotypic distinctiveness, two strains are suggested to represent two novel species of the genus Treponema , for which the names Treponema berlinense sp. (kenyon.edu)
  • The type species is Treponema pallidum . (thefreedictionary.com)
  • Treponema species, which are members of the family Spirochaetaceae , are fastidious anaerobic or microaerophilic host-associated spirochetes. (asm.org)
  • While the majority of Treponema species are found in the flora of humans and animals, a few species are pathogenic for humans. (asm.org)
  • Consider for example their Figure 6 and 7 which show that the most closely related Treponema species and the ones with the most similar genomes to these human Spirochaetes are those from Treponema succinifaciens and Treponema brennabornese . (blogspot.com)
  • Species of Treponema are generally considered as anaerobic, host-associated spirochetes that represent one of nine spirochetal genera of the phylum Spirochaetes as based on 16S rRNA sequence analysis. (caister.com)
  • This study investigated the presence of the Treponema species in longstanding endodontic retreatment-resistant lesions of teeth with apical periodontitis, the association of this species with clinical/radiographic features, and the association among the different target species. (ufrgs.br)
  • Treponema species were detected in 28% (7/25) of the cases. (ufrgs.br)
  • Strain ZAS-9 is proposed as the type strain of the new species, Treponema azotonutricium . (asm.org)
  • Strains ZAS-1 and ZAS-2, which are H 2 -consuming, CO 2 -reducing homoacetogens, are proposed here to be two strains of the new species Treponema primitia . (asm.org)
  • Moreover, the clones themselves were remarkably diverse at what could be considered the species level (i.e., many had 16S rRNA sequences ≤97% similar to each other [ 28 ]), even within individual termites, which were found to harbor two dozen or more species of Treponema ( 5 , 23 ). (asm.org)
  • Treponema carateum is the cause of pinta . (wikipedia.org)
  • 2006 ?Treponema calligyrum ♠ Noguchi ?Treponema carateum ♥ (pinta-causing Treponema) ?Treponema minutum ♦ Dobell 1912 ?Treponema pallidum ♦ (Schaudinn and Hoffmann 1905) Schaudinn 1905 T. p. endemicum ♠ Smibert 1984 (bejel-causing Treponema) T. p. pallidum ♠ (Schaudinn and Hoffmann 1905) Schaudinn 1905 (syphilis-causing Treponema) T. p. pertenue ♠ Smibert 1984 (yaws-causing Treponema) ?Treponema paraluisleporis ♠ Lumeij et al. (wikipedia.org)
  • Espezie patogenoen artean Treponema pallidum - sifiliaren eragilea- eta Treponema carateum dira aipagarrienak. (wikipedia.org)
  • pallidum , endemicum , and pertenue , the agents of venereal syphilis, endemic syphilis, and yaws, respectively, together with Treponema carateum , the agent of pinta, are primary pathogens of humans that have eluded in vitro cultivation ( 70 ). (asm.org)
  • Treponema is a genus of spiral-shaped bacteria. (wikipedia.org)
  • Treponema (family Spirochaetaceae, order Spirochaetales ) A genus of flexible, spirally shaped bacteria which are anaerobic or micro-aerophilic chemo-organotrophs . (encyclopedia.com)
  • Treponema (trep-ŏ- nee -mă) n. a genus of anaerobic spirochaete bacteria. (encyclopedia.com)
  • From the Greek trepo (rotate, turn) and ne¯ma (thread), Treponema is a genus of gram-negative, anaerobic or microaerophilic bacteria. (cdc.gov)
  • Treponema pallidum belongs to the family Spirochaetaceae , order Spirochaetales , phylum Spirochaetes , which is a phylogenetically ancient and distinct group of bacteria. (hindawi.com)
  • The FTA-ABS test is a blood test to detect antibodies to the bacteria Treponema pallidum, which causes syphilis. (walkinlab.com)
  • Reclassification of Treponema hyodysenteriae and Treponema innocens in a new genus, Serpula gen. nov., as Serpula hyodysenteriae comb. (wikipedia.org)
  • Monitoring experimental swine dysentery: rectal swab blood test and Serpulina (Treponema) hyodysenteriae detection. (nih.gov)
  • In two experiments, ten postweaning piglets were inoculated intragastrically with cultures of Serpulina (Treponema) hyodysenteriae strain B204 and were individually monitored for swine dysentery. (nih.gov)
  • Serotype-specific opsonization of Treponema hyodysenteriae. (asm.org)
  • Treponema hyodysenteriae was shown to attach to mouse peritoneal cells in the absence of serum opsonins in vitro. (asm.org)
  • Novel method for measuring growth of Treponema hyodysenteriae and its application for monitoring susceptibility of clinical isolates to antimicrobial agents. (asm.org)
  • A microdilution assay method was developed to determine MICs of antibiotics for Treponema hyodysenteriae and to estimate the bacterial burden of mice colonized by this swine pathogen. (asm.org)
  • Characterization and differentiation of a soluble lipopolysaccharide type antigen from Treponema hyodysenteriae. (arizona.edu)
  • Syphilis: RPR reactive, but negative for treponema pallidum antibodies? (medhelp.org)
  • The following line item shows treponema pallidum antibodies: negative. (medhelp.org)
  • The MP Diagnostics TP ELISA 4.0 is an enzyme-linked immunosorbent assay (ELISA) for qualitative detection of antibodies to Treponema Pallidum in human serum or plasma specimens. (mpbio.com)
  • Significant associations were also observed between haemodialysis status and antibodies to Treponema pallidum (Fisher's exact test p-value=0.044). (eurosurveillance.org)
  • Sera from mothers were tested for Treponema pallidum and Toxoplasma gondii infection while newborns from mothers with acute infections were tested for T. pallidum and T. gondii, and all newborns were tested for Rubella IgM antibodies. (ajol.info)
  • Detection of treponema pallidum specific antibodies by high performance liquid chromatography and it's clinical evaluation]. (semanticscholar.org)
  • CDC's Division of STD Prevention is making available a Treponema pallidum subspecies pallidum ( T. pallidum ) strain propagated in rabbits for research and development purposes. (cdc.gov)
  • Treponema pallidum is a motile, spirochaete bacterium that has subspecies that can cause treponemal diseases such as syphilis, pinta, bejel, and yaws. (kenyon.edu)
  • Microarrays containing all 1039 annotated ORFs of Treponema pallidum subspecies pallidum (Nichols) were printed on glass slides. (muni.cz)
  • Syphilis is caused by a thin, tightly coiled spirochete, Treponema pallidum subspecies pallidum ( 119 ). (antimicrobe.org)
  • In recent years, considerable progress has been made in topologically and functionally characterizing integral outer membrane proteins (OMPs) of Treponema pallidum subspecies pallidum, the syphilis spirochete, and identifying its surface-exposed β-barrel domains. (diva-portal.org)
  • Any of a group of spirochetes of the genus Treponema, including those that cause syphilis, pinta, and yaws. (thefreedictionary.com)
  • This is in stark contrast to the minimal genome of Treponema pallidum which encodes only 1,040 ORFs. (wikipedia.org)
  • The complete genome of Treponema pallidum , contained in one circular chromosome, was sequenced and shown to contain 1,138,006 base pairs predicted to encode 1,041 genes. (kenyon.edu)
  • Genome sequence analysis of Treponema pallidum , the causative agent of syphilis, suggests that this bacterium has a limited iron requirement with few, if any, proteins that require iron. (pnas.org)
  • Complete genome sequence of Treponema paraluiscuniculi , strain Cuniculi A: the loss of infectivity to humans is associated with genome decay. (cdc.gov)
  • N2 - Using Comparative Genomic Sequencing (CGS) approach, hypervariable regions in Treponema pallidum genome were identified. (muni.cz)
  • P1.011 Whole Genome Sequence of the Treponema Pallidum Ssp. (bmj.com)
  • Moreover, through genome reconstruction (2.2-2.5 MB, coverage depth × 26-513) and functional potential characterization, we discover these Treponema are diverse, fall outside of pathogenic clades and are similar to Treponema succinifaciens, a known carbohydrate metabolizer in swine. (blogspot.com)
  • PLOS Neglected Tropical Diseases: Whole Genome Sequence of Treponema pallidum ssp. (plos.org)
  • Treponema generoa bakterio Gram negatiboz osatuta dago, Spirochaetaceae familia barnean sailkatuta izanik. (wikipedia.org)
  • [1] Treponema paraluiscuniculi is associated with syphilis in rabbits . (wikipedia.org)
  • 1994 ?Treponema paraluiscuniculi ♦ (Jacobsthal 1920) Smibert 1974 ?Treponema pertenue ♦ (Castellani 1905) Castellani & Chalmers 1910 ?Treponema phagedenis ♠ T. p. phagedenis ♠ (Noguchi 1912) Brumpt T. p. vaccae ♠ Evans et al. (wikipedia.org)
  • Molecular detection of Treponema pallidum ssp. (muni.cz)
  • Penicillin-binding proteins of 180, 89, 80, 68, 61, 41, and 38 kilodaltons were identified in Treponema pallidum (Nichols) by their covalent binding of [35S]benzylpenicillin. (asm.org)
  • High rates of 23S rDNA mutations implicated in macrolide resistance have been identified in Treponema pallidum samples from syphilis patients in many countries. (unboundmedicine.com)
  • When person have syphilis, they develop positive treponema pallidum antibody tests BEFORE they develop a positive RPR. (medhelp.org)
  • This antibody reacts with Treponema pallidum in bacterial and infected tissue samples. (abcam.com)
  • Treponema pallidum IgG ELISA Kit is used for the detection of IgG antibody to Treponema pallidum in human serum or plasma. (novusbio.com)
  • Two patients (3%, 95%CI: 0-10%) were positive for Treponema pallidum and 18% (95%CI: 10-30%) were human herpesvirus 8 (HHV-8) antibody positive. (eurosurveillance.org)
  • Although Treponema pallidum adheres to host cells and is susceptible to bactericidal and opsonic antibody, the bacterial molecules involved in those functions have not been defined. (rupress.org)
  • Preliminary assessment of Treponema pallidum-specific IgM antibody detection and a new rapid point-of-care assay for the diagnosis of syphilis in human immunodeficiency virus-1-infected patients. (edu.au)
  • Treponema pallidum complement fixation test ( Treponema pallidum hemagglutinin test ) ( Treponema pallidum immobilization test ) formerly common serological tests for the diagnosis of syphilis , related directly to the causative organism. (thefreedictionary.com)
  • Treponema Pallidum protein is suitable for ELISA and Western blots, excellent antigen for detection of Trp. (prospecbio.com)
  • The automated haemagglutination assay using Treponema pallidum antigen (AMHA-TP) and the Venereal Disease Research Laboratory (VDRL) test were used to examine 330 163 sera. (bmj.com)
  • Colorized light micrograph showing Treponema pallidum, the bacterium that causes syphilis. (sciencephoto.com)
  • The lack of in vitro culture techniques and genetic systems for Treponema pallidum has made it extremely difficult to identify virulence or regulatory factors involved in the pathogenesis of syphilis. (pnas.org)
  • The fundamental reason for this controversy is the inability to culture Treponema pallidum in vitro on routine culture media or in tissue culture. (antimicrobe.org)
  • molecular typing}, language = {eng}, location = {Neuveden}, pages = {495-495}, publisher = {European Society of Clinical Microbiology and Infectious Diseases}, title = {Sequencing and molecular typing of hypervariable loci in the Treponema pallidum genomes: characterizations of type strains and clinical isolates. (muni.cz)
  • Recombinant Treponema p17 produced in E.coli is a non-glycosylated polypeptide chain having a molecular mass of 16.4kDa and fused to a His tag at N-terminus. (prospecbio.com)
  • Major breakthroughs include sequencing of Treponema genomes and the development of modern molecular methods. (caister.com)
  • Cultivation-independent (molecular phylogenetic) analysis of several hundred spirochetal 16S rRNA gene clones obtained from a variety of termites revealed that all were affiliated with the genus Treponema . (asm.org)
  • Treponema pallidum has been termed a 'stealth pathogen' because of its lack of surface proteins. (kenyon.edu)
  • The sensitive and specific nested PCR method was used for detection of the 47 kDa treponema pallidum protein (tpp47) gene. (uni-muenchen.de)
  • A phylogenetic analysis clustered the 16S rRNA gene in the Treponema genus group. (dtu.dk)
  • It is intended for screening of blood donors and as an aid in the diagnosis of clinical conditions related to infection with Treponema Pallidum. (mpbio.com)
  • As reported, in November 2013, the FDA already published a Draft Guidance for Industry:Use of Donor Screening Tests to Test Donors of Human Cells, Tissues and Cellular and Tissue-Based Products (HCT/Ps) for Infection with Treponema pallidum (Syphilis) . (gmp-compliance.org)
  • 1. Immune sera produced in rabbits by treatment with our Culture Strain A of Treponema pallidum agglutinated not only the homologous strain, but also the Noguchi strains, and indicate a close group relationship of other non-pathogenic treponemata. (rupress.org)
  • The recombinant protein technology considerably promoted the development of rapid and accurate treponema-specific laboratory diagnostics of syphilis infection. (hindawi.com)
  • Small volumes of Treponema pallidum p17 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. (mybiosource.com)
  • There are currently no images for Treponema pallidum ELISA Kit (KA0968). (novusbio.com)
  • Be the first to review our Treponema pallidum ELISA Kit (Colorimetric) and receive a gift card or discount. (novusbio.com)
  • Treponema pallidum is the causative agent of syphilis. (kenyon.edu)
  • Treponema pallidum , the causative agent of syphilis and the most extensively studied treponeme, is an obligate parasite meaning that it cannot exist outside the host, because it lacks the ability to synthesize essential nutrients, and consequently needs to obtain them from the host. (kenyon.edu)
  • After the discovery of Treponema pallidum (1905), the causative agent of syphilis, and the effective use of the antibiotic penicillin to treat the disease (1943), the diagnosis and elimination of syphilis appeared to be easy. (uni-muenchen.de)
  • The document provides updated recommendations concerning donor testing for evidence of Treponema pallidum ( T. pallidum ) infection, the etiologic agent of syphilis for establishments that make donor eligibility determinations for donors of human cells, tissues and cellular and tissue-based products (HCT/P Establishments). (gmp-compliance.org)
  • Treponema pallidum is a gram-negative spirochaete bacterium and is considered to be metabolically crippled. (prospecbio.com)
  • Beside the usefulness of a PCR-based assay for understanding the aetiology of lesions of late syphilis, the assay described can be of clinical importance in various situations where traditional methods fail to detect Treponema pallidum because of lack of sensitivity. (nih.gov)
  • Treponema Pallidum protein was purified by proprietary chromatographic technique. (prospecbio.com)
  • 2006 ?Treponema refringens ♠ (Schaudinn and Hofmann 1905) Castellani and Chalmers ?Treponema vincentii ♠ Smibert 1984 ?Treponema zioleckii ♠ Piknova et al. (wikipedia.org)
  • Nach der Endeckung des Erregers, Treponema pallidum (1905), und dem Einsatz des Antibiotikums Penicillin in der Syphilis-Therapie (1943) schienen Diagnostik und Bekämpfung der Syphilis nur noch eine Routineaufgabe. (uni-muenchen.de)
  • Carbon metabolism - Treponema sp. (kegg.jp)
  • Of the 44 oral samples cultivated, 15 (34%) were found to be positive for Treponema using electron microscopy and were also culture positive. (asm.org)
  • Treponema pallidum under electron microscopy. (kenyon.edu)
  • The purpose of this study was to evaluate the diagnostic performance of LIAISON Treponema Screen (DiaSorin, Saluggia, Italy), a new automated chemiluminescence immunoassay (CLIA), in comparison with that of rapid plasma reagin (RPR) and the following currently used treponemal tests: hemagglutination test (TPHA), immunoenzymatic assay (EIA), and Western blot (WB). (asm.org)
  • Macrolide-resistant strains of Treponema pallidum are now prevalent in several developed countries. (asm.org)
  • IMPORTANCE Despite recent progress characterizing outer membrane proteins (OMPs) of Treponema pallidum, little is known about how their surface-exposed, beta-barrel-forming domains vary among strains circulating within high-risk populations. (muni.cz)
  • However, application of specific epithets to the strains isolated ( Treponema strains ZAS-1, ZAS-2, and ZAS-9) was postponed pending a more complete characterization of their phenotypic properties. (asm.org)
  • The isolates were simply referred to as Treponema strains ZAS-1, ZAS-2, and ZAS-9, with assignment of specific epithets postponed until a more detailed characterization of the strains could be performed. (asm.org)
  • 1999 Treponema bryantii Stanton and Canale-Parola 1980 Treponema caldarium (Pohlschroeder et al. (wikipedia.org)