Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Elements of limited time intervals, contributing to particular results or situations.
A treatment method in which patients are under direct observation when they take their medication or receive their treatment. This method is designed to reduce the risk of treatment interruption and to ensure patient compliance.
A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
Evaluation procedures that focus on both the outcome or status (OUTCOMES ASSESSMENT) of the patient at the end of an episode of care - presence of symptoms, level of activity, and mortality; and the process (ASSESSMENT, PROCESS) - what is done for the patient diagnostically and therapeutically.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The return of a sign, symptom, or disease after a remission.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
MYCOBACTERIUM infections of the lung.
Voluntary cooperation of the patient in following a prescribed regimen.
Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Disorders related or resulting from abuse or mis-use of opioids.
Disorders related to substance abuse.
A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication.
Health facilities providing therapy and/or rehabilitation for substance-dependent individuals. Methadone distribution centers are included.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
An infant during the first month after birth.
Therapy with two or more separate preparations given for a combined effect.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Hospitals which provide care to patients with long-term illnesses.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.
Habitual moderation in the indulgence of a natural appetite, especially but not exclusively the consumption of alcohol.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.
Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Discontinuance of care received by patient(s) due to reasons other than full recovery from the disease.
A method for extinguishing anxiety by a saturation exposure to the feared stimulus situation or its substitute.
Disorders related or resulting from use of cocaine.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
A specialized residential treatment program for behavior disorders including substance abuse. It may include therapeutically planned group living and learning situations including teaching of adaptive skills to help patient functioning in the community. (From Kahn, A. P. and Fawcett, J. Encyclopedia of Mental Health, 1993, p320.)
The therapy of the same disease in a patient, with the same agent or procedure repeated after initial treatment, or with an additional or alternate measure or follow-up. It does not include therapy which requires more than one administration of a therapeutic agent or regimen. Retreatment is often used with reference to a different modality when the original one was inadequate, harmful, or unsuccessful.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Simultaneous infection of a host organism by two or more pathogens. In virology, coinfection commonly refers to simultaneous infection of a single cell by two or more different viruses.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
The application of modern theories of learning and conditioning in the treatment of behavior disorders.
Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Medical treatment for opioid dependence using a substitute opiate such as METHADONE or BUPRENORPHINE.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
The concurrent or retrospective review by practicing physicians or other health professionals of the quality and efficiency of patient care practices or services ordered or performed by other physicians or other health professionals (From The Facts On File Dictionary of Health Care Management, 1988).
A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).
Agents inhibiting the effect of narcotics on the central nervous system.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Disease having a short and relatively severe course.
The period of confinement of a patient to a hospital or other health facility.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
A scale that assesses the outcome of serious craniocerebral injuries, based on the level of regained social functioning.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Those factors which cause an organism to behave or act in either a goal-seeking or satisfying manner. They may be influenced by physiological drives or by external stimuli.
The phase of orthodontics concerned with the correction of malocclusion with proper appliances and prevention of its sequelae (Jablonski's Illus. Dictionary of Dentistry).
An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
A behavior therapy technique in which deep muscle relaxation is used to inhibit the effects of graded anxiety-evoking stimuli.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Health care services provided to patients on an ambulatory basis, rather than by admission to a hospital or other health care facility. The services may be a part of a hospital, augmenting its inpatient services, or may be provided at a free-standing facility.
The co-existence of a substance abuse disorder with a psychiatric disorder. The diagnostic principle is based on the fact that it has been found often that chemically dependent patients also have psychiatric problems of various degrees of severity.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
The ratio of the number of conceptions (CONCEPTION) including LIVE BIRTH; STILLBIRTH; and fetal losses, to the mean number of females of reproductive age in a population during a set time period.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Substances that reduce the growth or reproduction of BACTERIA.
A pyrazine that is used therapeutically as an antitubercular agent.
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing pain.
Tumors or cancer of the NOSE.
A dental specialty concerned with the prevention and correction of dental and oral anomalies (malocclusion).
The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
Substances interfering with the metabolism of ethyl alcohol, causing unpleasant side effects thought to discourage the drinking of alcoholic beverages. Alcohol deterrents are used in the treatment of alcoholism.
The confinement of a patient in a hospital.
Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.
Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.
A selective serotonin uptake inhibitor that is used in the treatment of depression.
A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
Drug regimens, for patients with HIV INFECTIONS, that aggressively suppress HIV replication. The regimens usually involve administration of three or more different drugs including a protease inhibitor.
Strong dependence, both physiological and emotional, upon heroin.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Social and economic factors that characterize the individual or group within the social structure.
Interactions between health personnel and patients.
Statistical interpretation and description of a population with reference to distribution, composition, or structure.
Persistent and disabling ANXIETY.
A republic in eastern Africa, south of SUDAN and west of KENYA. Its capital is Kampala.
Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
Substances obtained from various species of microorganisms that are, alone or in combination with other agents, of use in treating various forms of tuberculosis; most of these agents are merely bacteriostatic, induce resistance in the organisms, and may be toxic.
A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
The branch of philosophy dealing with the nature of the beautiful. It includes beauty, esthetic experience, esthetic judgment, esthetic aspects of medicine, etc.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
A republic in southern Africa, the southernmost part of Africa. It has three capitals: Pretoria (administrative), Cape Town (legislative), and Bloemfontein (judicial). Officially the Republic of South Africa since 1960, it was called the Union of South Africa 1910-1960.
Assessment of psychological variables by the application of mathematical procedures.
A form of group psychotherapy. It involves treatment of more than one member of the family simultaneously in the same session.
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Tumors or cancer of the human BREAST.
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.
Treatment that combines chemotherapy with radiotherapy.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Compounds that specifically inhibit the reuptake of serotonin in the brain.
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Tumors or cancer of the NASOPHARYNX.
Procedures used for the targeted destruction of the mucous membrane lining of the uterine cavity.
Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
A range of values for a variable of interest, e.g., a rate, constructed so that this range has a specified probability of including the true value of the variable.
Tumors or cancer of the LUNG.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.
A republic in southern Africa east of ZAMBIA and MOZAMBIQUE. Its capital is Lilongwe. It was formerly called Nyasaland.
Presentation devices used for patient education and technique training in dentistry.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
The excessive use of marijuana with associated psychological symptoms and impairment in social or occupational functioning.
A second-line antitubercular agent that inhibits mycolic acid synthesis.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Diminished or absent ability of a female to achieve conception.
An interval of care by a health care facility or provider for a specific medical problem or condition. It may be continuous or it may consist of a series of intervals marked by one or more brief separations from care, and can also identify the sequence of care (e.g., emergency, inpatient, outpatient), thus serving as one measure of health care provided.
Conscious or unconscious emotional reaction of the therapist to the patient which may interfere with treatment. (APA, Thesaurus of Psychological Index Terms, 8th ed.)
The performance of the basic activities of self care, such as dressing, ambulation, or eating.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.
Persons who receive ambulatory care at an outpatient department or clinic without room and board being provided.
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Moving a retruded mandible forward to a normal position. It is commonly performed for malocclusion and retrognathia. (From Jablonski's Dictionary of Dentistry, 1992)
A state of harmony between internal needs and external demands and the processes used in achieving this condition. (From APA Thesaurus of Psychological Index Terms, 8th ed)

Perioperative growth hormone treatment and functional outcome after major abdominal surgery: a randomized, double-blind, controlled study. (1/106051)

OBJECTIVE: To evaluate short- and long-term effects of perioperative human growth hormone (hGH) treatment on physical performance and fatigue in younger patients undergoing a major abdominal operation in a normal postoperative regimen with oral nutrition. SUMMARY BACKGROUND DATA: Muscle wasting and functional impairment follow major abdominal surgery. METHODS: Twenty-four patients with ulcerative colitis undergoing ileoanal J-pouch surgery were randomized to hGH (12 IU/day) or placebo treatment from 2 days before to 7 days after surgery. Measurements were performed 2 days before and 10, 30, and 90 days after surgery. RESULTS: The total muscle strength of four limb muscle groups was reduced by 7.6% in the hGH group and by 17.1% in the placebo group at postoperative day 10 compared with baseline values. There was also a significant difference between treatment groups in total muscle strength at day 30, and at the 90-day follow-up total muscle strength was equal to baseline values in the hGH group, but still significantly 5.9% below in the placebo group. The work capacity decreased by approximately 20% at day 10 after surgery, with no significant difference between treatment groups. Both groups were equally fatigued at day 10 after surgery, but at day 30 and 90 the hGH patients were less fatigued than the placebo patients. During the treatment period, patients receiving hGH had reduced loss of limb lean tissue mass, and 3 months after surgery the hGH patients had regained more lean tissue mass than placebo patients. CONCLUSIONS: Perioperative hGH treatment of younger patients undergoing major abdominal surgery preserved limb lean tissue mass, increased postoperative muscular strength, and reduced long-term postoperative fatigue.  (+info)

Single blind, randomised controlled trial of pelvic floor exercises, electrical stimulation, vaginal cones, and no treatment in management of genuine stress incontinence in women. (2/106051)

OBJECTIVE: To compare the effect of pelvic floor exercises, electrical stimulation, vaginal cones, and no treatment for genuine stress incontinence. DESIGN: Stratified, single blind, randomised controlled trial. SETTING: Multicentre. PARTICIPANTS: 107 women with clinically and urodynamically proved genuine stress incontinence. Mean (range) age was 49.5 (24-70) years, and mean (range) duration of symptoms 10.8 (1-45) years. INTERVENTIONS: Pelvic floor exercise (n=25) comprised 8-12 contractions 3 times a day and exercise in groups with skilled physical therapists once a week. The electrical stimulation group (n=25) used vaginal intermittent stimulation with the MS 106 Twin at 50 Hz 30 minutes a day. The vaginal cones group (n=27) used cones for 20 minutes a day. The untreated control group (n=30) was offered the use of a continence guard. Muscle strength was measured by vaginal squeeze pressure once a month. MAIN OUTCOME MEASURES: Pad test with standardised bladder volume, and self report of severity. RESULTS: Improvement in muscle strength was significantly greater (P=0.03) after pelvic floor exercises (11.0 cm H2O (95% confidence interval 7.7 to 14.3) before v 19.2 cm H2O (15.3 to 23.1) after) than either electrical stimulation (14.8 cm H2O (10. 9 to 18.7) v 18.6 cm H2O (13.3 to 23.9)) or vaginal cones (11.8 cm H2O (8.5 to 15.1) v 15.4 cm H2O (11.1 to 19.7)). Reduction in leakage on pad test was greater in the exercise group (-30.2 g; -43. 3 to 16.9) than in the electrical stimulation group (-7.4 g; -20.9 to 6.1) and the vaginal cones group (-14.7 g; -27.6 to -1.8). On completion of the trial one participant in the control group, 14 in the pelvic floor exercise group, three in the electrical stimulation group, and two in the vaginal cones group no longer considered themselves as having a problem. CONCLUSION: Training of the pelvic floor muscles is superior to electrical stimulation and vaginal cones in the treatment of genuine stress incontinence.  (+info)

Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine. The European Study Group. (3/106051)

OBJECTIVE: To assess intermittent treatment over 12 months in patients with symptomatic gastro-oesophageal reflux disease. DESIGN: Randomised, multicentre, double blind, controlled study. Patients with heartburn and normal endoscopy results or mild erosive changes received omeprazole 10 mg or 20 mg daily or ranitidine 150 mg twice daily for 2 weeks. Patients remaining symptomatic had omeprazole 10 mg or ranitidine dose doubled for another 2 weeks while omeprazole 20 mg was continued for 2 weeks. Patients who were symptomatic or mildly symptomatic were followed up for 12 months. Recurrences of moderate or severe heartburn during follow up were treated with the dose which was successful for initial symptom control. SETTING: Hospitals and primary care practices between 1994 and 1996. SUBJECTS: 677 patients with gastro-oesophageal reflux disease. MAIN OUTCOME MEASURES: Total time off active treatment, time to failure of intermittent treatment, and outcomes ranked from best to worst. RESULTS: 704 patients were randomised, 677 were eligible for analyses; 318 reached the end of the study with intermittent treatment without recourse to maintenance antisecretory drugs. The median number of days off active treatment during follow up was 142 for the entire study (281 for the 526 patients who reached a treatment related end point). Thus, about half the patients did not require treatment for at least 6 months, and this was similar in all three treatment groups. According to outcome, 378 (72%) patients were in the best outcome ranks (no relapse or one (or more) relapse but in remission until 12 months); 630 (93%) had three or fewer relapses in the intermittent treatment phase. Omeprazole 20 mg provided faster relief of heartburn. The results were similar in patients with erosive and non-erosive disease. CONCLUSIONS: Intermittent treatment is effective in managing symptoms of heartburn in half of patients with uncomplicated gastro-oesophageal reflux disease. It is simple and applicable in general practice, where most patients are seen.  (+info)

Optimal thrombolytic strategies for acute myocardial infarction--bolus administration. (4/106051)

Optimal strategies for thrombolysis in myocardial infarction (TIMI) are still being sought because the TIMI 3 flow rates achievable using standard regimens average approximately 60%. Double bolus administration of recombinant tissue plasminogen activator (tPA) is a novel approach with potential for earlier patency combined with ease of administration. We reviewed total patency rates, TIMI 3 patency rates, mortality, stroke and intracranial haemorrhage rates in the major trials of accelerated infusion tPA/bolus tPA/reteplase in acute myocardial infarction. A direct comparison was performed with results of two recent trials of double bolus (two 50 mg boli, 30 min apart) vs. accelerated infusion tPA: the Double Bolus Lytic Efficacy Trial (DBLE), an angiographic study, and the COBALT Trial, a mortality study. The DBLE trial showed equivalent patency rates for accelerated infusion and double bolus administration of tPA. Reviewing other angiographic trials, total patency and TIMI 3 patency rates achievable with double bolus tPA were comparable to those with accelerated infusion tPA or bolus reteplase administration. The COBALT study demonstrated a 30-day mortality of 7.53% in patients treated with accelerated infusion tPA compared with 7.98% for double bolus tPA treated patients. The small excess in mortality with double bolus treatment was confined to the elderly; in those < or = 75 years, mortality rates were 5.6% and 5.7%, for double bolus and accelerated infusion, respectively, and rates for death or non-fatal stroke were 6.35% and 6.3%, respectively. Comparison with other trials demonstrated mortality, stroke and intracranial haemorrhage rates with double bolus treatment similar to those associated with either accelerated infusion tPA or bolus reteplase treatment. Double bolus administration of tPA to patients with acute myocardial infarction is associated with total patency, TIMI 3 patency, mortality, stroke and intracranial haemorrhage rates similar to those associated with either accelerated infusion of tPA or bolus reteplase.  (+info)

Late referral of end-stage renal failure. (5/106051)

We studied all new patients accepted for renal replacement therapy (RRT) in one unit from 1/1/96 to 31/12/97 (n = 198), to establish time from nephrology referral to RRT, evidence of renal disease prior to referral and the adequacy of renal management prior to referral. Sixty four (32.3%, late referral group) required RRT within 12 weeks of referral. Fifty-nine (29.8%) had recognizable signs of chronic renal failure > 26 weeks prior to referral. Patients starting RRT soon after referral were hospitalized for significantly longer on starting RRT (RRT within 12 weeks of referral, median hospitalization 25.0 days (n = 64); RRT > 12 weeks after referral, median 9.7 days (n = 126), (p < 0.001)). Observed survival at 1 year was 68.3% overall, with 1-year survival of the late referral and early referral groups being 60.5% and 72.5%, respectively (p = NS). Hypertension was found in 159 patients (80.3%): 46 (28.9%) were started on antihypertensive medication following referral, while a further 28 (17.6%) were started on additional antihypertensives. Of the diabetic population (n = 78), only 26 (33.3%) were on an angiotensin-converting-enzyme inhibitor (ACEI) at referral. Many patients are referred late for dialysis despite early signs of renal failure, and the pre-referral management of many of the patients, as evidenced by the treatment of hypertension and use of ACEI in diabetics, is less than optimal.  (+info)

Tumour ablation and hepatic decompensation rates in multi-agent chemoembolization of hepatocellular carcinoma. (6/106051)

Thirty-seven cirrhotic patients with 62 hepatocellular carcinoma (HCC) foci--most Child-Pugh class B or C and/or with large, inoperable tumours--underwent 148 sessions of transcatheter arterial chemoembolization (TACE) using lipiodol, doxorubicin and cisplatin. Treatment efficacy was assessed by serial hepatic arteriography in 34/37 (91.9%) patients and abdominal CT scanning in 3/37 (8.1%) patients. Child-Pugh status was determined prior to each treatment session. Varying degrees of control of tumour neovascularity occurred for a median 390 days (range 90 to > 1680 days) in 33/34 (97.1%) patients in whom progress hepatic arteriography was performed. Ablation of tumour neovascularity occurred in 6/6 (100%), 4/12 (33.3%) and 6/16 (37.5%) patients with HCC diameters < 4 cm, 4-7 cm and > 8 cm, respectively (p < 0.02). Significantly more sessions were required for ablation of larger tumours (p < 0.05). Recurrent HCC was detected in 50% of patients after a median 240 days (range 60-1120 days). Deterioration in Child-Pugh status followed a session of TACE on 19/148 (12.8%) occasions but resulted in unscheduled hospitalization on only 4/148 (2.7%) occasions, the highest incidence (8.3%) in Child-Pugh C patients. Actuarial survival was 27/36 (75.0%) at 6 months, 17/34 (50.0%) at 12 months, 14/34 (41.2%) at 18 months, 9/31 (29.0%) at 24 months and 4/27 (14.8%) at 36 months. Multi-agent TACE with lipiodol, doxorubicin and cisplatin provides a useful anti-tumour effect, even in cirrhotic patients with large HCCs. The incidence of clinically significant deterioration in hepatic function due to ischaemia of non-tumorous liver is acceptably low, even in Child-Pugh C patients.  (+info)

Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, double-blind, placebo-controlled trial. (7/106051)

OBJECTIVE: To determine whether interferon-alpha (IFNalpha) reduces the severity of skin involvement in early (<3 years) diffuse scleroderma. METHODS: In a randomized, placebo-controlled, double-blind trial, 35 patients with early scleroderma received subcutaneous injections of either IFNalpha (13.5 x 10(6) units per week in divided doses) or indistinguishable placebo. Outcomes assessed were the modified Rodnan skin score, as determined by a single observer at baseline, 6 months, and 12 months, as well as data on renal, cardiac, and lung function. Pre- and posttreatment skin biopsy samples were analyzed and blood was obtained for assessment of procollagen peptide levels. RESULTS: There were 11 withdrawals from the IFNalpha group and 3 from the placebo group due to either toxicity, lack of efficacy, or death. In the intent-to-treat analysis, there was a greater improvement in the skin score in the placebo group between 0 and 12 months (mean change IFNalpha -4.7 versus placebo -7.5; P = 0.36). There was also a greater deterioration in lung function in patients receiving active therapy, as assessed by either the forced vital capacity (mean change IFNalpha -8.2 versus placebo +1.3; P = 0.01) or the diffusing capacity for carbon monoxide (mean change IFNalpha -9.3 versus placebo +4.7; P = 0.002). Skin biopsy showed no significant decrease in collagen synthesis in the IFNalpha group, and no significant differences in the levels of procollagen peptides were seen between the 2 groups. CONCLUSION: This study suggests that IFNalpha is of no value in the treatment of scleroderma, and that it may in fact be deleterious.  (+info)

Economic consequences of the progression of rheumatoid arthritis in Sweden. (8/106051)

OBJECTIVE: To develop a simulation model for analysis of the cost-effectiveness of treatments that affect the progression of rheumatoid arthritis (RA). METHODS: The Markov model was developed on the basis of a Swedish cohort of 116 patients with early RA who were followed up for 5 years. The majority of patients had American College of Rheumatology (ACR) functional class II disease, and Markov states indicating disease severity were defined based on Health Assessment Questionnaire (HAQ) scores. Costs were calculated from data on resource utilization and patients' work capacity. Utilities (preference weights for health states) were assessed using the EQ-5D (EuroQol) questionnaire. Hypothetical treatment interventions were simulated to illustrate the model. RESULTS: The cohort distribution among the 6 Markov states clearly showed the progression of the disease over 5 years of followup. Costs increased with increasing severity of the Markov states, and total costs over 5 years were higher for patients who were in more severe Markov states at diagnosis. Utilities correlated well with the Markov states, and the EQ-5D was able to discriminate between patients with different HAQ scores within ACR functional class II. CONCLUSION: The Markov model was able to assess disease progression and costs in RA. The model can therefore be a useful tool in calculating the cost-effectiveness of different interventions aimed at changing the progression of the disease.  (+info)

Looking for alternative treatment options for your older dog? Today we are looking at 6 alternative treatment options for senior dogs that you can consider.
Special diet:. Diet therapy is one of the important ADHD alternative treatment methods. Changes in the diet may help your child to deal with allergy symptoms or migraine headaches.. Biofeedback: This ADHD alternative treatment method helps your child to control their own responsibilities. This therapy involves a large commitment from your whole family.. This ADHD alternative treatment option helps children learn coping skills and that give them a sense of control and mastery. This therapy helps to reduce stress and anger that can accompany with ADHD.. Herbal medicine: Herbs act as ADHD alternative treatment method. You can find a number of all natural herbal treatments sold in the United States for the control of ADHD in children. Herbs can help to calm your child and they play important role in memory and thinking.. Make sure that herbs you are using are pure, safe, and nontoxic. Herbs can cause side effects and can interact with other medications.. Some of the herbs as ADHD alternative ...
As Table 3 shows, Case 1 presented with significant clinical improvement in rule following and working memory overtime, Case 2 presented with significant clinical improvement in cognitive flexibility, and rule following, while Case 3 presented with significant clinical improvement in cognitive flexibility, inhibition response and speed processing. As can be seen in Table 3, Case 1 presented a significant clinical improvement in social skills and behavior regulation, Case 2 presented with significant clinical improvement in emotional regulation and social skills, while Case 3 presented significant clinical deterioration in behavior regulation, emotional regulation and social skills over time.. DiscussionCognitive functions. Cognitive function domains included verbal comprehension, perceptual reasoning and IQ. Case 1 who had a cavernous angioma on the right frontal lobe showed an improvement followed by a decrease in verbal comprehension and perceptual reasoning, the results obtained in the last ...
To examine the association between the use and timing of IFN-α2b and clinical outcomes, we analyzed in a retrospective multicenter cohort study of 446 COVID-19 patients in Hubei, China. Regression models estimated that early administration (≤5 days after admission) of IFN-α2b was associated with reduced in-hospital mortality in comparison with no admission of IFN-α2b, whereas late administration of IFN-α2b was associated with increased mortality. Among survivors, early IFN-α2b was not associated with hospital discharge or computed tomography (CT) scan improvement, whereas late IFN-α2b was associated with delayed recovery. Additionally, early IFN-α2b and umifenovir alone or together were associated with reduced mortality and accelerated recovery in comparison with treatment with lopinavir/ritonavir (LPV/r) alone. Administration of IFN-α2b during the early stage of COVID-19 could induce favorable clinical responses.. ...
Medication is the most important treatment for bipolar disorders. I will outline the medication listed in the textbook and state their potential side effects and limitations in point form.Drug: LithiumLithium is the first choice of treatment for bipola...
We report a case of the 59-year-old men with portal hypertension and liver cirrhosis, who developed pulmonary arterial hypertension. The first line treatment with sildenafil 20 mg 3 times daily was introduced as part of a Polish National Treatment Program. At a 6-month follow-up we noticed a significant clinical improvement: the patients exercise capacity and echocardiographic parameters were substantially better. In addition, the B-type natriuretic propeptide significantly decreased. ...
Of 242 patients in CT group and 215 patients in no CT group, stage I to IV disease were 1.7%, 38.4%, 58.7%,1.2% and 5.6%, 46%, 47%, 1.4%, respectively. Pretreatment imaging found lymph node and/or distant metastases in 43.4% and upstaged in 27.6% of patients, according to the 7th AJCC system. Treatment modifications were elicited in 21.9% of patients; RT (13.2%), CMT (4.1%) and both (4.5%). At median follow-up time of 35 months, progression-free survival (PFS) and overall survival (OS) at 3 years in CT and no CT group were 70.1% vs 74.7% (p = 0.135) and 68.3% vs 76.4% (p = 0.016). Subgroup analysis by stage showed that patients with stage II disease in CT and no CT group had no significant difference in 3-year PFS and OS; 80.3% vs 83.3% (p = 0.673) and 81.3% vs 79.7% (p = 0.802), respectively. In stage III disease, patients in both groups had no significant difference in 3-year PFS, 64.1% in CT group and 68.4% in no CT group (p = 0.187). However, the 3-year OS was significantly worse in CT ...
TY - JOUR. T1 - Lymphadenectomy in Gleason 7 prostate cancer. T2 - Adherence to guidelines and effect on clinical outcomes. AU - Chandrasekar, Thenappan. AU - Goldberg, Hanan. AU - Klaassen, Zachary W A. AU - Sayyid, Rashid K.. AU - Hamilton, Robert J.. AU - Fleshner, Neil E.. AU - Kulkarni, Girish S.. PY - 2018/1. Y1 - 2018/1. N2 - Background To examine usage trends, guideline adherence, and survival data for patients undergoing lymphadenectomy (LND) at the time of radical prostatectomy (RP) for Gleason 7 prostate cancer (PCa). Methods The SEER database was queried for all patients with nonmetastatic biopsy Gleason 7 PCa from 2004 to 2013. Distribution and trends of LND were analyzed. The Memorial-Sloan Kettering Cancer Center nomogram was applied to stratify patients based on risk of nodal disease at time of RP (,5% risk or ≥5% risk). Analyses were performed to determine covariates associated with LND receipt at time of RP and cancer-specific mortality (CSM). Results A total of 78,641 ...
Women now have the choice to be given epidural anesthesia to help with pain during active labor. Local anesthetic will be administered into the epidural space of the spine which will be given continuously through a small catheter that is left taped to the womans back. It normally takes about five to thirty minutes for the effects to be felt, at which time the legs may begin to feel heavy and pain should subside. While it is generally safe for both the woman and baby when having an epidural, there are potential side effects they should be aware of.. Low blood pressure is one of the most common effects. Intravenous fluids will be administered at the same time in order to prevent this from occurring. Another common side effect is uncontrollable shivering. However, shivering is something that can happen to a woman during labor even without receiving an epidural, so getting an warm blanket is often enough to help control the shivers.. A loss of bladder control during labor can sometimes happen ...
BACKGROUND: Myocardial infarction (MI) in the absence of electrocardiographic ST-segment elevation or new bundle branch block is the cause of hospitalization for a large and steadily increasing proportion of patients with acute ischemic chest pain. Despite its prevalence, the common demographic features, current hospital-based management, and short-term clinical outcome among patients with non-ST-segment elevation MI remain poorly defined. METHODS: A total of 183 113 patients with non-ST-segment elevation MI were identified in the National Registry of Myocardial Infarction database. Using a validated model, 43 928 patients (24.0%) were retrospectively placed in major, 34 917 (19.1%) in intermediate, and 104 268 (56.9%) in minor severity clinical event categories that included hospital death, recurrent myocardial ischemia, and nonfatal recurrent MI. RESULTS: The administration of widely available and universally recommended pharmacologic therapies, including aspirin and beta-adrenergic blocking agents,
Myself and certain member(s) of the AM community wondered if there were any potential side effects to be concerned with (or to look out for) when
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Downloadable! Recently there has been a surge in econometric work focusing on estimating average treatment effects under various sets of assumptions. One strand of this literature has developed methods for estimating average treatment effects for a binary treatment under assumptions variously described as exogeneity, unconfoundedness, or selection on observables. The implication of these assumptions is that systematic (e.g., average or distributional) differences in outcomes between treated and control units with the same values for the covariates are attributable to the treatment. Recent analysis has considered estimation and inference for average treatment effects under weaker assumptions than typical of the earlier literature by avoiding distributional and functional form assumptions. Various methods of semiparametric estimation have been proposed, including estimating the unknown regression functions, matching, methods using the propensity score such as weighting and blocking, and combinations of
This is a randomized, double-blind, placebo-controlled, multicenter Phase III clinical trial to compare the efficacy and safety of Fruquintinib plus BSC versus placebo plus BSC in patients with metastatic colorectal cancer who have progressed after second-line or above standard chemotherapy. After checking eligibility criteria, subjects will be randomized into Fruquintinib plus BSC group (treatment group) or placebo plus BSC group (control group) in a ration of 2:1. Primary Efficacy Endpoint: Overall Survival (OS). Secondary Efficacy Endpoints: Progression free survival (PFS) (According to RECIST Version 1.1), Objective Response Rate (ORR), Disease Control Rate (DCR), . Safety and tolerance will be evaluated by incidence, severity and outcomes of AEs and categorized by severity in accordance with the NCI CTC AE Version 4.0 ...
This study compared two doses of pembrolizumab (MK-3475) versus docetaxel in participants with non-small cell lung cancer (NSCLC) who had experienced disease progression after platinum-containing systemic therapy. Participants were assigned randomly to receive either pembrolizumab 2 mg/kg once every three weeks (Q3W), pembrolizumab 10 mg/kg Q3W or docetaxel 75 mg/m^2 Q3W. This study used an adaptive trial design so that the total number of participants randomized depended upon demonstration of sufficient objective responses at an interim analysis.. Based on the positive outcome of the Overall Survival (OS) analysis, Protocol Amendment 12 (effective date: 09 Dec 2015) enabled eligible participants who were allocated to docetaxel and experienced disease progression, to be permitted to crossover to receive pembrolizumab 2 mg/kg Q3W as long as Inclusion/Exclusion criteria were met. These participants were participating in the Cross-Over Phase.. The primary study hypotheses are that pembolizumab ...
Duration of response was defined as progression-free survival in responders, i.e. as the time between the start of a complete response (CR) or partial response (PR) and the start of progressive disease (PD) or patient death from any cause, whichever occurred first. Participants who did not have progression or had not died were censored at the last known time the participant was progression free. Participants who had initiated other anticancer therapy prior to progression were censored at the time when new anticancer therapy was initiated. Complete response (CR) and partial response (PR) were defined in outcome #1. Progressive disease was defined as at least a 20% increase in the sum of the longest diameters of target lesions; or the appearance of one or more new lesions; or the unequivocal progression of a non-target lesion. Response was evaluated using Response Evaluation Criteria in Solid Tumors (RECIST ...
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The 12 groups, recognized by CDRRMO, are not affiliated with any barangay and do not receive any regular funding for their efforts and operations. Disaster responders of barangays are funded from their DRRM or five percent of the internal revenue allotment.. They are vital to the CDRRMO because they augment our resources and capacity during the implementation of some programs like the City Wide Simulation Exercises and especially during times of disasters, said Lyndon Leovic Ancajas, CDRRMO training officer.. Ancajas added that volunteer responders go through trainings and drills to improve their skills and capacity.. Carlo Danilo de Leon, president of the EAGLES Disaster Rescue Group, one of the largest volunteer responder groups in the city with over 600 members, welcomed the support given to them by the CDRRMO.. These equipment will enable us to respond better and keep us safe during operations, de Leon said.. Raniel Nocom, president of another volunteer responder group called Darcom, ...
Background. Minimally invasive surgery is increasingly applied because of the proven better outcome and benefits for the patient such as less pain, shorter hospital stay, and less injury. Examples of such minimally invasive procedure include Endovascular Aortic Repair (EVAR), endovascular coiling of intracranial aneurysms, and Transcatheter Aortic Valve Implantation (TAVI). These procedures have in common that a device is transported through the iliac and aortic artery after an incision in the groin to the problematic location in the body. Unfortunately, these percutaneous procedures are associated with vascular complications of the iliac artery. These vascular complications include bleeding, vascular rupture, aneurysm spurium, ateriorvenous fistula, dissection, and embolism. There are various clinical and technical procedural parameters associated with these vascular complications. Next to these parameters, the morphology and disease of the vasculature also influence the risk of vascular ...
What are the alternative options for kidney disease with 30% kidney function ? Are dialysis and renal transplant are the only options for them ?
A Randomized, Multicenter, Open Label Study of MM-302 plus Trastuzumab vs. Chemotherapy of Physicians Choice plus Trastuzumab in Anthracycline Naive Patients with Locally Advanced/Metastatic HER2-Positive Breast ...
This Phase IIIb study was conducted to evaluate the safety, efficacy and pharmacokinetics of darunavir/cobicistat 800/100 mg once daily in HIV-1-infected adults with no darunavir RAMs who also received two fully active N[t]RTIs. We showed that darunavir/cobicistat 800/150 mg once daily was well tolerated, and the pharmacokinetics, virologic and immunologic responses were consistent with previously published data for darunavir/ritonavir 800/100 mg once daily.. Through Week 24, the onset of any grade 3 or 4 AEs regardless of causality was low (6% in the overall population). Five out of 313 patients (2%), all of whom were treatment-naïve, experienced any study drug-related grade 3 AE through Weeks 24 and 48. No patients experienced grade 4 drug-related AEs. The most commonly reported AEs of all grades during the study, diarrhea, nausea, upper respiratory tract infection and headache, have all been reported previously for darunavir and cobicistat [5-8, 15, 16]. Renal laboratory assessments showed ...
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DALLAS and TOKYO, Nov. 19, 2013- Daiichi Sankyos Once-Daily Edoxaban Meets Primary Efficacy Endpoint for Stroke Prevention and Superiority for the Principal Safety Endpoint Compared to Warfarin for Patients with Atrial Fibrillation in a Phase 3 Clinical Trial.
Question - Took all the possible treatment for sinus. Should i go for sinus surgery? . Ask a Doctor about diagnosis, treatment and medication for Allergic rhinitis, Ask an ENT Specialist
The incidence statistics of type 2 diabetes mellitus can only be reduced if individualized comprehensive treatment is offered to each patient, but without just leaving his illness, said Felix Scott, general manager of Sanofi Mexico.. In the framework of the International Forum of Leaders in Diabetes, the director said that people with this condition should not be considered mere figures, because each of them has its own reality.. He pointed out that pharmaceutical companies need to develop innovative medicines every day to improve and facilitate therapies, as well as to guide the physician with new tools and training in digital technologies to better monitor their patients.. Although the person with diabetes, he said, should be seen as a person who is the center of all efforts, understands his needs and his individual and family environment, because there are sufficient reasons for not adhering to the treatment.. Results will not be achieved at the statistical level, if we do not achieve ...
Generally, Diabetes easily causes Kidney Failure if patients do not take timely treatments. Well then, what is the comprehensive treatment for stage 4 kidney failure caused by diabetes?
Effectiveness at end of January 2013 was estimated to be 92%.. Coverage at end of January was estimated (using SQUEAC) to be 63%.. Impact can be estimated as:. Impact = Effectiveness x Coverage = 92% x 63% = 58%. Data courtesy of ACF (Pakistan). Coverage also depends indirectly on:. Thorough case-finding and early treatment seeking: This ensures that the majority of admissions are uncomplicated incident cases, which leads to good outcomes (Figure 1). Late admission is associated with the need for inpatient care, longer treatment, defaulting, and poor treatment outcomes (e.g. nonresponse after long stays in programme or death). These can lead to poor opinions of the programme circulating in the host population, which may lead to more late presentations and admissions and a cycle of negative feedback may develop (Figure 2). A high level of compliance by both the beneficiary and the provider: This ensures that the beneficiary receives a treatment of proven efficacy leading to good outcomes and good ...
Cancer 101 is a source for all the information related to cancer. Know about the common types of cancer, diagnosis, possible treatments and prevention tips.
Question - Pain in back gums, treated with salt water. Gums swollen, throbbing, itchy. Possible treatment? . Ask a Doctor about diagnosis, treatment and medication for Back pain, Ask a Dentist
Comprehensive treatment is undertaken for the majority of patients during the early teens. Treatment aims to create a beautiful, balanced and functional
Contemporary Management of HIV: Modifying Antiretroviral Therapy in Virologically Suppressed Patients and Those with Treatment ...
therapy. Treatment was continued until disease progression, discontinuation due to adverse events, or withdrawal of consent. Randomization was stratified according to PSA doubling time (≤ 6 months or , 6 months) and use of osteoclast-targeted therapy at randomization. The primary endpoint was metastasis-free survival in the intention-to-treat population, with the presence of metastasis identified by independent central review of radiographic imaging every 16 weeks.. For the darolutamide vs placebo groups, the median age was 74 years in both, most patients were from European countries, PSA doubling time was up to 6 months in 70% vs 67%, the Eastern Cooperative Oncology Group performance status was 0 or 1 in 100% in both, 97% vs 94% were not using a bone-sparing agent at baseline, and 76% of both groups had received at least 2 previous hormonal therapies.. Metastasis-Free Survival. On independent central review, metastasis was found at baseline in 5.2% of the darolutamide group and 7.0% of the ...
TY - JOUR. T1 - A case of reductions in bone and brain metastatic foci and remarkable improvements in general condition by gefitinib administrations in a patient with non-small cell lung carcinoma of progressive stage. AU - Hirose, Masahiro. AU - Tachikawa, Soichi. AU - Horiguchi, Takahiko. AU - Kondo, Reiko. AU - Shiga, Mamoru. AU - Sasaki, Yasushi. AU - Ito, Tomohiro. AU - Fukumoto, Koji. AU - Torigoe, Hiroshi. AU - Kobayashi, Kashin. AU - Hayashi, Nobuyuki. AU - Watanabe, Yasushi. AU - Oohira, Daisuke. PY - 2005/4/7. Y1 - 2005/4/7. N2 - A 60-year-old male patient, who presented at our hospital mainly complaining of pain in the shoulders and back, was diagnosed with stage IV primary B4 pulmonary adenocarcinoma (T3N0M1 with bone and brain metastases) based on a transbronchial lung biopsy (TBLB). Although chemotherapy was conducted after radio-surgical treatment of the brain metastatic focus with the γ-knife, his joint pain and general condition were exacerbated, in addition to the occurrence ...
The purpose of the study is to compare safety and efficacy of a single dose of empegfilgrastimt a dose of 3 or 6 mg versus daily administration of filgrastim at
Purpose: This multicenter, open-label, phase II study evaluated the safety and clinical activity of axitinib, a potent and selective second-generation inhibitor of vascular endothelial growth factor receptors (VEGFR)-1, 2, and 3, in patients with metastatic melanoma.. Experimental Design: Thirty-two patients with a maximum of one prior systemic therapy received axitinib at a starting dose of 5 mg twice daily. The primary endpoint was objective response rate.. Results: Objective response rate was 18.8% [95% confidence interval (CI), 7.2-36.4], comprising one complete and five partial responses with a median response duration of 5.9 months (95% CI, 5.0-17.0). Stable disease at 16 weeks was noted in six patients (18.8%), with an overall clinical benefit rate of 37.5%. Six-month progression-free survival rate was 33.9%, 1-year overall survival rate was 28.1%, and median overall survival was 6.6 months (95% CI, 5.2-9.0). The most frequently (,15%) reported nonhematologic, treatment-related adverse ...
A national, multi-center, open-label, phase IIIb trial to determine the efficacy and safety of treatment with ribociclib (LEE011) plus letrozole in women and
Randomised, double-masked, sham-controlled Phase 3b/4 study. All patients received 3 monthly IVT-AFL 2 mg injections. At Week 12, patients were randomised 1:1 into IVT-AFL plus sham PDT (IVT-AFL monotherapy) or IVT-AFL plus active PDT arms. Patients in both arms who did not qualify for rescue treatment received IVT-AFL 2 mg every 8 weeks (2q8); patients who qualified for rescue treatment received IVT-AFL 2q4 plus active or sham PDT, according to the randomisation arm, until visual and anatomical outcomes allowed for extension of the treatment interval. The primary efficacy endpoint was the mean change in BCVA in the study eye from baseline to Week 52. The secondary efficacy endpoint was the proportion of patients avoiding a moderate vision loss (≥15 letters) from baseline to Week 52. Exploratory endpoints included but were not limited to: (1) change in central subfield thickness ([CST] thickness of the central 1 mm of retina) over time; (2) proportion of patients with active polyps; (3) ...
A clinical trial of the Guardian implantable heart attack monitor made by Angel Medical Systems failed to meet its efficacy endpoint, but suggested that the device could be used to help detect silent heart attacks.. Wilmington, Del.-based AngelMed won FDA clearance a year ago for the Guardian device for patients with prior acute coronary syndrome events including myocardial infarctions or unstable angina at high risk for further ACS events. Its 907-patient Alerts study randomized patients implanted with Guardian to either six months with the alert function active for the treatment group or six months without activation for the control arm; both groups had the alert function activated after the six-month randomized stage.. The primary efficacy endpoint, a confirmed occlusive event within 7 days, was not significantly reduced for the treatment arm at 3.8%, compared with 4.9% for the control arm. The primary safety endpoint was met a 96.7% rate of freedom from device-related complications, ...
This pragmatic cluster RCT implemented in CHSs in urban China found no differential treatment effect in the primary outcome measure, HbA1c, with intervention and control groups both improving significantly. However, significant treatment effects favouring the intervention group were evident in psychological distress, systolic BP, waist circumference in men and SDSCA-Specific Diet. Two of these outcomes (psychological distress and systolic BP) were robust outcomes consistent with significant treatment effects, as supported in sensitivity analyses.. In addition to being statistically significant, the greater psychological distress observed in the control group compared with that in the intervention group is of clinical significance. The shift in the mean score for the control group at baseline from 14.97±6.24 to 17.45±8.12 at 12 months translates clinically to a shift in the mean from low risk of psychological distress (scores 10-15) to moderate risk of psychological distress (16-21).27 This ...
Background: Superiority clinical trials hold promises of impactful interventions for the future of evidence-based medicine but require extensive resources and may place study patients at risk. Advances made through cardiovascular (CV) trials in past decades have drastically improved patient outcomes, but little is known about the modern landscape of CV superiority trials and how it has evolved over time.. Methods: We performed a comprehensive search in PubMed using keywords and MeSH terms to identify all superiority CV trials with a primary clinical endpoint from January 1, 2006 to December 31, 2011 in the New England Journal of Medicine (NEJM), JAMA, and the Lancet. We used chi-square and Cochran-Armitage Trend tests to assess for statistical significance.. Results: We identified 188 trials (108 drug trials, 20 device trials and 60 others). Overall, 69 trials (36.7%) had positive results, demonstrating superiority of the new intervention for the primary endpoint, while 119 trials (63.3%) showed ...
Multiple treatment comparison (MTC) meta-analysis uses both direct (head-to-head) randomized clinical trial (RCT) evidence as well as indirect evidence from RCTs to compare the relative effectiveness of all included interventions. The methodological quality of MTCs may be difficult for clinicians to …
Lung Institute White Paper Reveals Evidence of Pulmonary Function Improvement from Stem Cell Therapy 21 Jan 2016 by Maren Auxier Lung Institute White Paper A new white paper released by the Lung Institute shows an increase of 10 percent or more in pulmonary function for 48 percent of patients tested after receiving stem cell therapy for COPD, with an overall average increase of 16 percent. TAMPA, Fla. January 26, 2016: Lung Institute doctor Jack Coleman, Jr., M.D. recently
ONGLYZA® (saxagliptin) achieves primary safety endpoint, demonstrating no increased risk for cardiovascular death, heart attack or stroke in SAVOR cardiovascular outcomes trial
TY - JOUR. T1 - Posttreatment infarct volumes when compared with 24-hour and 90-day clinical outcomes. T2 - Insights from the REVASCAT randomized controlled trial. AU - Al-Ajlan, F. S.. AU - Sultan, A. S.Al. AU - Minhas, P.. AU - Assis, Z.. AU - Miquel, M. A.De. AU - Millan, M.. AU - San Roman, L.. AU - Tomassello, A.. AU - Demchuk, A. M.. AU - Jovin, T. G.. AU - Cuadras, P.. AU - Davalos, A.. AU - Goyal, M.. AU - Menon, B. K.. N1 - Funding Information: REVASCAT was funded by a local independent Catalan institution (Fundació Ictus Malaltia Vascular) through an unrestricted grant from the manufacturer of the device (Covidien). This project has been partially supported by a grant from the Spanish Ministry of Health cofinanced by FEDER (Instituto de Salud Carlos III, RETICS-INVICTUS PLUS, RD 16/0019).. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background and Purpose: Endovascular therapy has become the standard of care for patients with disabling anterior circulation ischemic stroke due to proximal ...
TY - JOUR. T1 - Network meta-analysis of antiplatelet therapy following coronary artery bypass grafting (CABG). T2 - none versus one versus two antiplatelet agents. AU - Chakos, Adam. AU - Jbara, Dean. AU - Singh, Kamal. AU - Yan, Tristan D.. AU - Tian, David H.. PY - 2018/9/1. Y1 - 2018/9/1. N2 - Background: Numerous agents have been trialed following coronary artery bypass grafting (CABG) to maintain long-term graft patency. While clear evidence exists for the use of aspirin in maintaining graft patency, the role of dual-antiplatelet therapy in CABG patients is not as well established. This network meta-analysis aimed to compare the short-term post-CABG graft patency outcomes for patients with none, one or two antiplatelet agents. Methods: Electronic databases were queried for randomized controlled trials comparing CABG graft patency rates at three months and beyond using various antiplatelet agents or placebo. Drug and graft patency data were compared using a mixed treatment comparison under ...
Impact of perioperative myocardial infarction on angiographic and clinical outcomes following coronary artery bypass grafting (from PRoject of Ex-vivo Vein graft ENgineering via Transfection [PREVENT] IV).
TY - JOUR. T1 - Long-term outcome following programmed electrical stimulation in patients with high-grade ventricular ectopy. AU - Kharsa, M. H.. AU - Gold, R. L.. AU - Moore, H.. AU - Yazaki, Y.. AU - Haffajee, C. I.. AU - Alpert, Joseph S. PY - 1988. Y1 - 1988. N2 - To determine if programmed electrical stimulation (PES) could be utilized to identify patients with high-grade ventricular ectopy at low- or high-risk for sudden cardiac death, we performed PES in 40 patients with high-grade ventricular ectopy refractory to conventional antiarrhythmic agents. Twenty-one patients had a previous myocardial infarction, five had cardiomyopathy, six had hypertension, three had valvular heart disease and five had no known structural heart disease. The mean age was 60 years (range, 18 to 76). During programmed ventricular stimulation, eight patients had inducible sustained (more than 30 seconds) monomorphic ventricular tachycardia (Group I) but in 32 patients sustained ventricular tachycardia was not ...
TY - JOUR. T1 - Factors influencing outcome in patients undergoing portal vein resection for adenocarcinoma of the pancreas. AU - Banz, V. M.. AU - Croagh, D.. AU - Coldham, C.. AU - Tanière, P.. AU - Buckels, J.. AU - Isaac, J.. AU - Mayer, Diane. AU - Muiesan, P.. AU - Bramhall, S.. AU - Mirza, D. F.. PY - 2012/1. Y1 - 2012/1. N2 - Background: Survival rates after surgery and adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PDA) remain low. Selected patients with portal/superior mesenteric vein (PV) involvement undergo PV resection at pancreaticoduodenectomy (PD). This study analyses outcomes for PD with/without PV resection in patients with PDA. Methods: A retrospective analysis of prospectively collected data on patients requiring PD for histologically proven adenocarcinoma between 1/1997 and 9/2009 identified 326 patients with PDA, with 51 requiring PD with PV resection. Patients were analyzed in two groups: PD + PV resection vs. PD alone. Multivariate analysis was used to ...
In this prospective study of a large cohort of patients with primary THA, we found that after adjusting for important predictors, patients with OA had significantly better functional outcomes compared to those with RA/inflammatory arthritis at two-year follow-up. Results were notable for overall ADL limitation and key ADLs. Pain outcomes were not significantly different for OA versus RA. We also found that patients with AVN experienced better ADL outcome at two years compared to RA patients. In contrast, patients with AVN reported worse pain outcomes at five years compared to those with RA. Several findings in our study are of interest and merit further discussion.. One of the main findings of our study was that patients with OA had significantly better functional outcomes compared to those with RA at the two-year follow-up, as indicated by lower odds of overall moderate-severe ADL limitation. These findings were confirmed for patients younger and older than 65 years. To our knowledge, this is ...
TY - JOUR. T1 - Erratum to Predictive value of white blood cell subtypes for long-term outcome following myocardial infarctions [Atherosclerosis 196 (2008) 405-412]. AU - Dragu, Robert. AU - Khoury, Shafik. AU - Zuckerman, Robert. AU - Suleiman, Mahmoud. AU - Mutlak, Diab. AU - Agmon, Yoram. AU - Kapeliovich, Michael. AU - Beyar, Rafael. AU - Markiewicz, Walter. AU - Hammerman, Haim. AU - Aronson, Doron. PY - 2012/4. Y1 - 2012/4. UR - http://www.scopus.com/inward/record.url?scp=84858701209&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84858701209&partnerID=8YFLogxK. U2 - 10.1016/j.atherosclerosis.2006.11.045. DO - 10.1016/j.atherosclerosis.2006.11.045. M3 - Article. AN - SCOPUS:84858701209. VL - 221. SP - 605. JO - Atherosclerosis. JF - Atherosclerosis. SN - 0021-9150. IS - 2. ER - ...
Neoadjuvant breast cancer trials are important for speeding up the introduction of new treatments for patients with early breast cancer and for the highly productive translational research which they facilitate. Meta-analysis of trial data shows clear correlation between pathological response at surgery after neoadjuvant chemotherapy and longer-term outcomes at an individual patient level. However, this does not appear to be present on individual trial level analysis, when correlating improved outcome for the investigational arm for the primary endpoint (pathological response) with longer-term outcomes. The correlation between pathological response and longer-term outcomes in trials is dependent on many factors. These include definitions of pathological response, both complete and partial; assessment methods for pathological response at surgery; subtype and prognosis of breast cancer at diagnosis; number of patients recruited; adjuvant treatments; the mechanism of action of the investigational drug; the
Dr. David Parish, co-creator and lead instructor for MOTUS Therapeutic Methods, goes on to say, I am a firm believer in the Olympic ideal of Citius, Altius, Fortius; Faster, Higher, Stronger, and I look to bring those ideals to those I treat and teach. MOTUS is the vessel that carries these ideals, it was built to drive continued improvement in application and education.. PerformTex could not be more proud of aligning and offering our complete support of the MOTUS system, states John Jarvis, marketing director for PerformTex Products LLC. By working with two, of whom many consider to be true innovators, leaders and visionarys within the world in regards to kinesiology taping and myofascial therapy treatment, we finally have a system in place created by practitioners for practitioners. We, as a team, will strive to offer the very best and truly offer actual advancement, in not only our product line, but educational offerings.. For more information on MOTUS Therapeutic Methods and its ...
The results of this study showed that, in patients with acute AC-LAO that was refractory to stentriever thrombectomy, permanent stenting achieved mTICI 2b-3 recanalization in 83.3% of cases, and the stent group had a significantly higher favorable outcome rate than the nonstent group without an increase in sICH or mortality. This suggests that permanent stenting may be a rescue treatment modality for stentriever-failed AC-LAO. The efficacy and safety of permanent stenting for recanalization of acute stroke were evaluated in several previous studies.10-14 In the era of stentriever thrombectomy, however, the efficacy of permanent stenting for stentriever-failed AC-LAO has remained unclear. To our knowledge, this is the first report comparing an SG with an NSG in patients with stentriever-failed AC-LAO, although the study performed was retrospective in nature.. In ≈30% of AC-LAO cases, stentriever thrombectomy failed to achieve mTICI 2b-3 recanalization.9 In 25.5% of the AC-LAO cases in this ...
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Migraine Rescue treatment is an integral part of effective Migraine management (such as NSAIDs). Discussion of possible migraine rescue treatments.
Comparison of one-year clinical outcomes between intravascular ultrasound-guided versus angiography-guided implantation of drug-eluting stents for left main lesions: a single-center analysis of a 1,016-patient cohort Xiao-Fei Gao,1,* Jing Kan,1,* Yao-Jun Zhang,1,2 Jun-Jie Zhang,1 Nai-Liang Tian,1 Fei Ye,1 Zhen Ge,1 Ping-Xi Xiao,1 Feng Chen,3 Gary Mintz,4 Shao-Liang Chen1 1Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Peopleâ s Republic of China; 2Thorax Center, Erasmus Medical Center, Rotterdam, the Netherlands; 3Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Peopleâ s Republic of China; 4Division of Cardiology, Cardiovascular Research Foundation, Columbia University, New York, NY, USA *These authors contributed equally contributed to this work Background: The importance of intravascular ultrasound (IVUS)-guided stenting of the unprotected left main coronary artery (ULMCA) remains controversial
Calamine lotion is an over-the-counter (OTC) medication that can help relieve mild itchiness, or pruritus. It can be used to treat a variety of skin irritations from poison ivy and chigger bites, to minor burns. Learn more about calamine: what its made of, how to use, and potential side effects.
A Phase II, Single Arm, Multicentre Open Label Trial to Determine the Safety and Efficacy of Tisagenlecleucel in Pediatric Subjects With Relapsed or Refractory Mature B-cell Non-Hodgkin Lymphoma (NHL)
In conjunction with the National Multiple Sclerosis Society (NMSS) the Difficult Cases Webinar is an informal webinar designed to help clinicians, investigators, researchers and other personnel discuss difficult cases of pediatric MS or other suspected demyelinating diseases. Once a month individuals participate in a one hour call/webinar to help the presenter come up with possible diagnoses, treatments, or solutions to their difficult cases. If you are interested in joining the Difficult Cases Webinar and would like to receive reminders about upcoming calls then please contact Liz Brown ([email protected]).. Difficult Case Webinar Flyer. ...
The average treatment effect (ATE) is a measure used to compare treatments (or interventions) in randomized experiments, evaluation of policy interventions, and medical trials. The ATE measures the difference in mean (average) outcomes between units assigned to the treatment and units assigned to the control. In a randomized trial (i.e., an experimental study), the average treatment effect can be estimated from a sample using a comparison in mean outcomes for treated and untreated units. However, the ATE is generally understood as a causal parameter (i.e., an estimate or property of a population) that a researcher desires to know, defined without reference to the study design or estimation procedure. Both observational studies and experimental study designs with random assignment may enable one to estimate an ATE in a variety of ways. Originating from early statistical analysis in the fields of agriculture and medicine, the term treatment is now applied, more generally, to other fields of ...
WASHINGTON, March 22, 2016 /PRNewswire-USNewswire/ -- PCORI Board Authorizes $22 Million to Compare Treatment Options for Chronic Low Back Pain. Also...
Background: Among ambulatory patients with heart failure (HF), hospital admission is associated with higher subsequent mortality. HF is the leading cause of 30-day all-cause readmission, reduction of which is a goal of the Affordable Care Act. We examined the association of 30-day all-cause readmission with subsequent all-cause mortality in a propensity-matched cohort of hospitalized HF patients.. Methods: Of the 8049 Medicare beneficiaries hospitalized for HF and discharged alive from 106 U.S. hospitals (1998-2001), 7578 were alive 30-day post-discharge, of which 1519 had 30-day all-cause readmission. Using propensity scores for 30-day all-cause readmission, we assembled a matched cohort of 1516 pairs of patients with and without 30-day all-cause readmission, balanced on 34 baseline characteristics.. Results: During 2-12 months of post-discharge follow-up, all-cause mortality occurred in 41% and 27% of matched patients with and without 30-day all-cause readmission, respectively (HR, 1.68; 95% ...
Objectives: Prompt Mental Health Care (PMHC) is the Norwegian version of the Englands Improving Access to Psychological Therapies (IAPT). Both programs have been associated with substantial symptom reductions from pre- to post-treatment. The present study extends these findings by investigating symptom levels at 12 months post-treatment, as well as treatment outcome in relation to low- vs. high-intensity treatment forms. Design and Outcome Measures: A prospective cohort design was used. All participants (n = 1530) were asked to complete the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 questionnaire (GAD-7) at baseline, before each session during treatment, at final treatment, and at 12 months post-treatment. Cohens d was used as effect size measure. Sensitivity analyses were conducted to examine the impact of the high missing data rates at post-treatment (≈44%) and 12 months post-treatment (≈58%). Results: A large symptom reduction was seen from baseline to ...
TY - JOUR. T1 - Effect of In-Hospital Initiation of Lipid-Lowering Therapy on Six-Month Outcomes in Patients With Acute Ischemic Stroke or Transient Ischemic Attack. AU - Yeh, Poh Shiow. AU - Lin, Huey Juan. AU - Bai, Chyi Huey. AU - Hsieh, Fang I.. AU - Ke, Der Shin. AU - Li, Yi Heng. PY - 2010/5/15. Y1 - 2010/5/15. N2 - Early lipid-lowering therapy (LLT) has demonstrated clinical benefits in patients with acute coronary syndrome; however, little is known about early LLT in patients with stroke. We evaluated the effect of in-hospital initiation of LLT on the clinical outcomes of patients with stroke. The Taiwan Stroke Registry prospectively collected data from patients with acute ischemic stroke or transient ischemic attack. By July 31, 2008, 16,704 adult patients without previous LLT had been admitted and survived to discharge. The study end point was the composite outcome of recurrent stroke, ischemic heart disease, and all-cause death. We examined the effect of LLT at discharge on the ...
TY - JOUR. T1 - Labour Market Status at Ages 50-64 and All-Cause Mortality at Ages 65-70: A Longitudinal Study from Finland. AU - Klein, Julia. AU - Saarela, Jan. PY - 2019. Y1 - 2019. N2 - Individuals labour market status and health are known to be highly correlated. To investigate this association beyond prime working ages, we study how all-cause mortality at ages 65-70 relates to different labour market positions at ages 50-64. The data stem from random samples of the Finnish population, which make it possible to follow 33,000 individuals in the period 1987-2011. Hazard models are estimated to quantify the associations. For both men and women, disability pensioners have a hazard of dying at age 65+ that is approximately twice that of persons who were employed, and this ratio still exceeds 1.5 when socioeconomic and demographic variables are included. Also male unemployment, but not female, is associated with an elevated mortality risk, but this interrelation depends greatly on socioeconomic ...
Are patient-reported outcomes useful in post-treatment follow-up care for women with early breast cancer? A scoping review Cathrine Lundgaard Riis,1-3 Troels Bechmann,1,2 Pernille Tine Jensen,4,5 Angela Coulter,2,3,6 Karina Dahl Steffensen1-3 1Department of Oncology, Vejle Hospital, Vejle, Denmark; 2Institute of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; 3Center for Shared Decision Making, Vejle, Denmark; 4Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark; 5Department of Clinical Research, University of Southern Denmark, Odense, Denmark; 6Nuffield Department of Population Health, University of Oxford, Oxford, UK Background: Patient-reported outcomes (PROs) are frequently used to evaluate treatment effects and quality of life in clinical trials. The application of PROs in breast cancer clinics is evolving but their use to generate real-time information for use in follow-up care is uncommon. This proactive use
To systematically assess adherence of randomised trials in surgery to Consolidated Standards of Reporting Trials (CONSORT) guidelines for non-pharmacological treatments (NPT). Surgical trials are considered more difficult to design and execute than pharmacological trials. Furthermore, the original CONSORT statement does not address some aspects that are vital to the transparent reporting of surgical trials. The CONSORT-NPT extension was designed to address these issues but adherence in medical and surgical journals has not been assessed.Cross-sectional study.We identified eight general medical and eight surgical journals, indexed in PubMed and published in 2011, with the highest impact factors in their respective categories.Adherence to CONSORT statement and CONSORT-NPT extension items.We identified 54 surgical trials (22 published in medical journals and 32 in surgical journals). There were eight items for which there was less than 30% overall compliance (seven were specific to the CONSORT-NPT
TY - JOUR. T1 - Colorectal cancer. T2 - How emerging molecular understanding affects treatment decisions. AU - Sridharan, Meera. AU - Hubbard, Joleen M.. AU - Grothey, Axel. PY - 2014/2/15. Y1 - 2014/2/15. N2 - The medical treatment of metastatic colorectal cancer (mCRC) has advanced significantly over the last 10 years as the result of the introduction of several active cytotoxic and biologic agents into standard clinical practice. Several recent phase III trials reported median overall survival data exceeding 30 months, an achievement inconceivable only 5 years ago. The first major step forward in the medical management of mCRC was provided by the addition of irinotecan and oxaliplatin to fluorouracil-based therapy; this increased survival from about 12 months to about 20 months. The introduction of biologic agents such as vascular endothelial growth factor inhibitors and epidermal groTawth factor inhibitors further increased survival-to more than 2 years in prospective trials. Recently, an ...
TY - JOUR. T1 - Contemporary Management of Critical Limb Ischemia the BEST Is Yet to Come. AU - Laird, John R.. AU - Singh, Gagan. AU - Armstrong, Ehrin J.. PY - 2016/4/26. Y1 - 2016/4/26. KW - big data. KW - critical limb ischemia. KW - national inpatient sample. KW - peripheral artery disease. UR - http://www.scopus.com/inward/record.url?scp=84962178621&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84962178621&partnerID=8YFLogxK. U2 - 10.1016/j.jacc.2016.02.041. DO - 10.1016/j.jacc.2016.02.041. M3 - Comment/debate. VL - 67. SP - 1914. EP - 1916. JO - Journal of the American College of Cardiology. JF - Journal of the American College of Cardiology. SN - 0735-1097. IS - 16. ER - ...
Two protestors (of whom one is handicapped) injured during Fridays lathicharge were moved to Bombay Hospital from GT Hospital on Saturday after they alleged that they experienced poor treatment and negligent health care at GT Hospital, reports Karthik Balasubramanian.
TY - JOUR. T1 - A retrospective multicenter study on long-term prevalence of chronic pain after cardiac surgery. AU - Claudio, Marcassa. AU - Pompilio, Faggiano. AU - Cesare, Greco. AU - Marco, Ambrosetti. AU - Luigi, Temporelli Pier. PY - 2015/11/11. Y1 - 2015/11/11. N2 - Background There are limited data on sternotomy as a cause of chronic postsurgical pain, mainly restricted to 1 year after surgery. Aims To assess the prevalence of chronic poststernotomy pain and its interference on daily living. Methods In three groups of patients, a standardized telephone interview was obtained at 3 months (nU313), 1 year (nU313), and 3 years (nU319) following the rehabilitation program after cardiac surgery, in 11 rehabilitation centers. Presence, site, and the severity and interference of pain on selected daily living items were assessed. Results The prevalence of pain after cardiac surgery was 35.3% in the 3-month group, 26.8% in the 1-year group, and 19.8% in the 3-year group (P. AB - Background There ...
The study evaluated the effects of a combination of bariatric procedure with intensive medical therapy (IMT) versus intensive medical therapy alone based o
PURPOSE A prolonged time to treatment initiation (TTI) correlates with an adverse prognosis in different cancer types including resectable pancreatic cancer (PC). Only limited evidence on the correlation between TTI and prognosis in advanced PC exists. METHODS Consecutive PC patients (n = 368) who were diagnosed or treated at our high-volume comprehensive cancer center were included in a prospectively maintained database. We retrospectively analyzed time from first imaging showing advanced PC to initiation of palliative first-line chemotherapy. Lead time bias and waiting time paradox were addressed by landmark analysis and correlation of tumor burden with TTI. RESULTS Two hundred and ninety-seven patients met the pre-specified in- and exclusion criteria of our study. Median TTI was 29~days (range: 1-124 days). Most common reasons for prolonged TTI (, 21 days) were referral from an external treatment center (39%) and a second biopsy (31%). A TTI above the median-, 75th or 90th percentile (43 or ...
CI, confidence interval; CR, complete response; PR, partial response; SD, stable disease; NE, not estimable. i. Enhertu 6.4 mg/kg.. ii. As assessed by independent central review.. iii. ORR is (CR + PR).. iv. DCR is (CR + PR + SD).. Patients were treated with a median of two prior lines of therapy (1-6) with most receiving platinum-based chemotherapy (90.5%) and anti-PD-1 or PD-L1 treatment (54.8%). Median treatment duration was 7.76 months (0.7-14.3) with a median duration of follow-up of 8.0 months (1.4-14.2). As of data cut-off on 25 November 2019, 45.2% of patients with HER2m metastatic NSCLC remained on treatment with Enhertu.. The overall safety and tolerability profile of Enhertu in DESTINY-Lung01 was consistent with that seen in the Phase I lung cancer trial and previously reported Enhertu trials.4 The most common Grade 3 or higher treatment-emergent adverse events were decreased neutrophil count (26.2%) and anaemia (16.7%). There were five cases (11.9%) of confirmed treatment-related ...
BACKGROUND AND OBJECTIVE: Following stroke, it is common to exhibit motor impairments and decreased use of the upper limb. The objective of the present study was to evaluate forced use on arm function during the subacute phase after stroke.. DESIGN: A comparison of standard rehabilitation only and standard rehabilitation together with a restraining sling was made through a randomized, nonblinded, clinical pilot trial with assessments before intervention, after intervention, and at 1- and 3-month follow-ups.. SETTING: The present study took place at the departments of rehabilitation medicine, geriatrics, and neurology at a university hospital.. PARTICIPANTS: A convenience sample of 30 people 1 to 6 months (mean, 2.4 mo) after stroke was randomized into 2 groups (forced-use group and standard training group) of 15 people each. Twenty-six participants completed the 3-month follow-up.. INTERVENTION: All participants received their standard rehabilitation program with training 5 days per week for 2 ...
Whilst there is much current data on early outcomes after Coronary artery bypass grafting(CABG), there is relatively little data on medium term outcomes in the current era. The purpose of this study is to present a single surgeon series comprising of all first time CABG patients operated on with the technique of cross clamp fibrillation from Feb-1996 to through to Jan-2003, and to seek risk factors for medium term mortality in these patients. Data was collected from Hospital Episode Statistics and departmental patient administration and tracking systems and cross checked using database techniques. Patient outcomes were searched using the National Health Service strategic tracing service. Mean follow up was 5.3 years(0-9.4 years) and was complete for all patients. 30-day survival was 98.4%, 1-year survival 95% and 8-year survival 79%. Cox-regression analysis revealed that several modifiable pre-operative risk factors remain significant predictors of medium term mortality, including Diabetes(Hazard Ratio
Inclusion Criteria: - Patients must have histologic evidence of relapsed or refractory B-cell ALL - Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less - Philadelphia chromosome positive (Ph+) patients must be refractory to or intolerant of standard tyrosine kinase inhibitor therapy - Patients must be able to consume oral medication - Patients must have recovered to =, grade 1 or stabilized from the toxic effects of any prior chemotherapy (except alopecia) - Creatinine clearance (CrCL) ,= 60 mL/min/1.73 m^2 calculated by Cockcroft-Gault - Total bilirubin , 1.5 x upper limit of normal (ULN) - Negative serum or urine pregnancy test for women with child-bearing potential - Patients must be able to sign consent and be willing and able to comply with scheduled visits, treatment plan, procedures, and laboratory testing Exclusion Criteria: - Patients must not have evidence of active central nervous system (CNS) disease - Patients must not be receiving any ...
January 26, 2018-Medtronic announced the initiation of its investigational device exemption (IDE) study that will evaluate the safety and effectiveness of the companys Abre venous self-expanding stent system in patients with iliofemoral venous outflow obstruction.. According to the company, the multicenter, single-arm study intends to enroll 200 patients with deep venous disease at up to 35 sites throughout the United States and Europe. The primary efficacy endpoint will evaluate patency at 12 months, which is defined by freedom from occlusion and freedom from clinically driven target lesion revascularization. The primary safety endpoint will evaluate the incidence of composite major adverse events at 30 days after stenting of an obstruction in the iliofemoral venous segment.. The Abre stent is premounted on a 9-F delivery system and features a nitinol stent with a triaxial shaft design. The stent utilizes an open-cell design with three connection points between the cells that are intended to ...
Purpose: To review the risk of local recurrence and impact of salvage therapy after Watch and Wait for rectal cancer with complete clinical response (cCR) after chemoradiation therapy (CRT). Methods and Materials: Patients with cT2-4N0-2M0 distal rectal cancer treated with CRT (50.4-54 Gy + 5-fluorouracil-based chemotherapy) and cCR at 8 weeks were included. Patients with cCR were enrolled in a strict follow-up program with no immediate surgery (Watch and Wait). Local recurrence-free survival was compared while taking into account Watch and Wait strategy alone and Watch and Wait plus salvage. Results: 90 of 183 patients experienced cCR at initial assessment after CRT (49%). When early tumor regrowths (up to and including the initial 12 months of follow-up) and late recurrences were considered together, 28 patients (31%) experienced local recurrence (median follow-up time, 60 months). Of those, 26 patients underwent salvage therapy, and 2 patients were not amenable to salvage. In 4 patients, ...
Furiex Pharmaceuticals has reported top-line results from the phase II trial of the investigational drug PPD-10558 in patients with statin-associated myalgia, or SAM. PPD-10558 did not meet its primary efficacy endpoint in this randomized, double-blind, proof-of-concept study. The study enrolled patients with high cholesterol and a prior history of SAM, and evaluated recurrence rates for SAM over a twelve-week treatment period across the following three different treatment regimens: placebo; PPD-10558; and atorvastatin (Lipitor). Patients did not report any significant differences in muscle symptoms, nor did they drop out due to SAM in significantly different percentages, among the three regimens. As expected, however, PPD-10558, a novel statin, did significantly lower LDL-cholesterol compared with placebo, and the compound also had a favorable safety profile.. Furiex acquired an exclusive license rights in 2007 from Ranbaxy Laboratories to develop, manufacture and market its novel statin ...
The therapeutic alliance has demonstrated an association with favorable psychotherapeutic outcomes in the treatment of eating disorders (EDs). However, questions remain about the inter-relationships between early alliance, early symptom improvement, and treatment outcome. We conducted a meta-analysis on the relations among these constructs, and possible moderators of these relations, in psychosocial treatments for EDs. Twenty studies met inclusion criteria and supplied sufficient supplementary data. Results revealed small-to-moderate effect sizes, βs = 0.13 to 0.22 (p , .05), indicating that early symptom improvement was related to subsequent alliance quality and that alliance ratings also were related to subsequent symptom reduction. The relationship between early alliance and treatment outcome was partially accounted for by early symptom improvement. With regard to moderators, early alliance showed weaker associations with outcome in therapies with a strong behavioral component relative to ...
THOUSAND OAKS, Calif., June 5, 2010 /PRNewswire via COMTEX/ --Amgen (Nasdaq: AMGN) today announced detailed results from a Phase 3, head-to-head trial which compared the efficacy and safety of denosumab versus Zometa(R) (zoledronic acid) in 1,901 patients with hormone-refractory prostate cancer and bone metastases. The study met its primary and secondary endpoints and demonstrated denosumabs superiority over Zometa in delaying or preventing skeletal related events (SREs). These statistically significant results will be presented in an oral session on June 6, 2010 at the American Society of Clinical Oncology (ASCO) 2010 Annual Meeting in Chicago (Late Breaking Abstract Number #LBA4507). In patients with skeletal metastases, the growing cancer cells weaken and destroy the bone around the tumor. This can result in a number of serious complications, collectively called SREs, comprising fracture, radiation to bone, surgery to bone or spinal cord compression. All can be serious complications for ...
Lambert, M. J. (2010). "Yes, it is time for clinicians to monitor treatment outcome." In B. L. Duncan, S. C., Miller, B. E. ... The SRS is designed to measure the therapeutic alliance given its importance in leading to positive treatment outcome Using ... The Partners for Change Outcome Management System (PCOMS) is a behavioral health outcomes management system for counseling and ... and is designed to be a briefer method to measure therapeutic outcome. PCOMS employs two brief, 4-item scales, the Outcome ...
"Presentation, treatment, and outcome differences between men and women undergoing revascularization or amputation for lower ... Outcomes Research evaluates the impact of health care on the health outcomes of patients and populations. This research may ... 2011). "Improving Observational Study Estimates of Treatment Effects Using Joint Modeling of Selection Effects and Outcomes: ... SOAR members hope, as part of the surgical outcomes research community, to improve overall outcomes for patients with surgical ...
... patients refusing investigation or treatment (informed dissent); patients with supervening conditions; cases where diagnostic/ ... The Quality and Outcomes Framework (QOF) is a system for the performance management and payment of general practitioners (GPs) ... Quality and outcomes framework guidance from NHS Employers Business Rulesets used to determine QOF achievement (All pages ...
No pharmacological treatment I 7. Treatment goal I 8. Socio-healthcare system. N 0. Need, unspecified N 1. Treatment based on ... Outcome. I 0. Information / Health education, unspecified I 1. Situation / reason for encounter I 2. Health problem I 3. ... Treatment based on public health issues N 4. Prevention N 5. Healthcare provision N 6. Complementary test for treatment control ... Complementary examination I 4. Risk I 5. Pharmacological treatment I 6. ...
Validation of a Behavioral Health Treatment Outcome and Assessment Tool Designed for Naturalistic Settings: The Treatment ... The outcomes assistant: A kinder philosophy to the management of outcomes. Kraus, D. R., Castonguay, L. G. and Wolf, A. 2006, ... A patented BHOM application, the Treatment Outcome Package or TOP, system helps large organizations (health plans, community ... Use of psychological testing for treatment planning and outcome assessment. 3rd. Mahway : Erlbaum, 2004, Vol. 3, pp. 191-234. ...
Saal JA, Saal JS (April 1989). "Nonoperative treatment of herniated lumbar intervertebral disc with radiculopathy. An outcome ... Ideally, effective treatment aims to resolve the underlying cause and restores the nerve root to normal function. Conservative ... Only low level evidence was found to support spinal manipulation for the treatment of chronic lumbar radiculopathies, and no ... A variety of exercise regimens are available in patient treatment. An exercise regimen should be modified according to the ...
Equality of treatment refers to either equality of opportunity or equality of outcome. Equality of opportunity requires ... Equality of outcome requires every individual to possess an equal share of outcomes such as goods or positions. The Convention ... Equality of treatment requires comparable situations to be treated in the same manner and prohibits direct and indirect ... "Equality of Outcome". Equality of Opportunity and Education. Retrieved 5 May 2016. "Convention on the Elimination of All Forms ...
The treatment was designed to reducing the drug use harm by Recognising the needs of families in AOD treatment stress-related ... A Controlled Outcome Study". Journal of Child & Adolescent Substance Abuse. 3 (3): 1-16. doi:10.1300/J029v03n03_01. ISSN 1067- ... issues related to young people's treatment and post-treatment that can help parents. The standard problem - solving model is ... "Transporting a research-based adolescent drug treatment into practice". Journal of Substance Abuse Treatment. 22 (4): 231-243. ...
They improve the treatment outcome. One of the recent methods in radiation therapy related to cancer care is called HDR (High ... New treatments make the radiation therapy curing cancer almost harmless without serious side effects of treatments. ... Even before that a stereotactic treatment was developed where the treatment is directed tridimensionally with the help of ... The synthesis of the IMRT and the stereotactic treatment is known as the Rapid Arc-technique developed in Finland that speeds ...
Rice, Kenneth G; Neimeyer, Greg J; Taylor, Jennifer M (December 2011). "Efficacy of coherence therapy in the treatment of ... procrastination and perfectionism". Counseling Outcome Research and Evaluation. 2 (2): 126-136. doi:10.1177/2150137811417975. ... Neimeyer, Robert A (January 2010). "Symptoms and significance: constructivist contributions to the treatment of performance ...
Lee, Joung H. (2009). Meningiomas: Diagnosis, Treatment, and Outcome. Springer. p. 8. ISBN 978-1-84882-910-7. Wood, Eric Fisher ...
... and the uncertain outcome of chemotherapy in brain tumors puts this treatment further down the line of treatment options with ... Treatments that use a person's immune system are being studied. Outcomes for malignant tumors vary considerably depending on ... This additional treatment provides some patients with improved outcomes and longer survival rates.[citation needed] ... Park BJ, Kim HK, Sade B, Lee JH (2009). "Epidemiology". In Lee JH (ed.). Meningiomas: Diagnosis, Treatment, and Outcome. ...
Nevertheless, the treatment of this type of meningioma remains a challenge with relatively frequent poor outcomes. The risk of ... Lee JH (2008-12-11). Meningiomata: Diagnosis, Treatment, and Outcome. Springer Science & Business Media. pp. 3-13. ISBN 978-1- ... menigioma is typically fatal without treatment due to its location. Until the 1970s no treatment was available for this type of ... A small percentage grow rapidly and are associated with worse outcomes. About one per thousand people in the United States are ...
Shapiro, Valerie (2001-2002). "Is Long-Term Residential Treatment Effective for Adolescents? A Treatment Outcome Study" (PDF). ... Therapeutic and Appropriate use of Residential Treatment (ASTART) and the Community Alliance for the Ethical Treatment of Youth ... GAO did not attempt to evaluate the benefits of residential treatment programs or verify the facts regarding the thousands of ... "Alliance for the Safe, Therapeutic and Appropriate use of Residential Treatment" (PDF). Federal Trade Commission (July 2008). " ...
470-. ISBN 978-0-08-045593-8. Joung H. Lee (11 December 2008). Meningiomas: Diagnosis, Treatment, and Outcome. Springer Science ... It is also used as an AAS in the treatment of anemia of renal failure. A series of case reports have found it to be effective ... Mepitiostane is used as an antiestrogen and antineoplastic agent in the treatment of breast cancer. ... group which is marketed in Japan as an antineoplastic agent for the treatment of breast cancer. It is a prodrug of epitiostanol ...
Treatment is by physically untwisting the testicle, if possible, followed by surgery. Pain can be treated with opioids. Outcome ... Typical treatment involves the use of over-the-counter analgesics and the condition resolves within 2-3 days.: 316 The ... Given the treatment implications of testicular torsion, it is important to distinguish testicular torsion from other causes of ... With prompt diagnosis and treatment the testicle can often be saved. Typically, when a torsion takes place, the surface of the ...
ISBN 978-0-86656-965-1. Moos, R.H.; Finney, J.W.; Cronkite, R.C. (1990). Alcoholism Treatment: Context, Process and Outcome. ... Some scholars and treatment providers assert that codependency is an overresponsibility and that overresponsibility needs to be ... An empirical review of clinical folklore". Journal of Substance Abuse Treatment. 10 (3): 303-316. doi:10.1016/0740-5472(93) ... "Codependent" No More?". Chiauzzi; Liljegren (1993). "Taboo topics in addiction treatment. ...
... does deferring treatment compromise outcome?". Am. J. Clin. Oncol. 26 (3): e60-6. doi:10.1097/01.COC.0000072507.25834.D6. PMID ... Most larger cancer treatment centers routinely check for the deletion of 1p/19q as part of the pathology report for ... With aggressive treatment and close monitoring, it is possible to outlive the typical life expectancies for low grade ... However, such figures can be misleading since they do not factor in the types of treatment nor the genetic signature of the ...
"Hearing Loss Treatment". ucsfhealth.org. Retrieved 2022-10-07. "Visual impairment: what is it, symptoms and treatment , Top ... "Optic Atrophy: Causes, Symptoms, Diagnosis & Outcome". Cleveland Clinic. Retrieved 2022-10-07. Ahmad SS, Kanukollu V (2022). " ... "Understanding Diagnosis and Treatment of Diabetes". WebMD. Retrieved 2022-10-07. "Hearing Loss Treatment Options". WebMD. ... "Diabetes treatments". Diabetes UK. Retrieved 2022-10-07. "Diabetes: Symptoms, Causes, Treatment, Prevention, and More". ...
Treatment protocol project 2004, p. 592 harvnb error: no target: CITEREFTreatment_protocol_project2004 (help) Marder, Stephen R ... "Health of the Nation Outcome Scales". The Royal College of Psychiatrists. 2008. Retrieved 2008-07-02. "Comprehensive ... Treatment Protocol Project (2003). Acute inpatient psychiatric care: a source book (2nd ed.). Darlinghurst, Australia: World ... The assessment is usually the first stage of a treatment process, but psychiatric assessments may also be used for various ...
The primary outcome was freedom from treatment failure after 16 weeks of therapy; the secondary outcome was attentional ... In the treatment of absence seizures there is often insufficient evidence for which of the available medications has the best ... Treatment of patients with absence seizures only is mainly with ethosuximide or valproic acid, which are of equal efficacy ... Dreifuss, FE (1983). "Treatment of the nonconvulsive epilepsies". Epilepsia. 24 Suppl 1: S45-54. doi:10.1111/j.1528-1157.1983. ...
"Consultant treatment outcomes". NHS England. Archived from the original on 6 October 2014. Retrieved 2 October 2014. "Heart ... HQIP Consultant Outcomes and HQIP Clinical Outcomes Technical Manual. He was a vocal participant in the debate about the Health ... Measuring clinical outcomes in cardiac surgery has led to a 50% reduction in mortality rates over the past 10 years. He has ... Ben Bridgewater: measuring outcomes for surgery Kings Fund 2011 Fourth EACTS Adult Cardiac Surgical Database Report: Towards ...
Researching IVF outcomes; Leading the world in the understanding, treatment and prevention of asthma; Developing programs to ... Some highlights include: Discovering that folate can prevent spina bifida; Hib meningitis vaccination; Improving outcomes for ... medical research institute focused on the prevention of paediatric disease and the development of improved treatments to ...
Outcomes are variable. The condition is rare and occurs most commonly in children. Fewer than one in 500,000 children is ... The CDC is setting up a task force to investigate the causes and to find treatments. "Acute Flaccid Myelitis" (PDF). www.dhs. ... Studies from 2014 to 2017 indicated a poor outcome for many cases. Seven of 61 cases with EVD68 detected and eight long‐term ... Treatment involves supportive care. Physical therapy may be recommended. Occasionally, mechanical ventilation is required to ...
Nin T, Umemoto M, Miuchi S, Negoro A, Sakagami M (May 2006). "[Treatment outcome in patients with taste disturbance]". Nihon ... Zinc supplementation may be an effective treatment in major depression. Zinc deficiency in children can cause delayed growth ... A review of pregnancy outcomes in women with acrodermatitis enteropathica, reported that out of every seven pregnancies, there ... Shah D, Sachdev HP (January 2006). "Zinc deficiency in pregnancy and fetal outcome". Nutrition Reviews. 64 (1): 15-30. doi: ...
Mbbs, M P Ferguson; Fraco, A A McNab (1999). "Current treatment and outcome in orbital cellulitis". Australian and New Zealand ... Without proper treatment, orbital cellulitis may lead to serious consequences, including permanent loss of vision or even death ... There is inadequate evidence to draw judgments about the use of steroids in the treatment of orbital cellulitis. More research ... Bacterial infections of the orbit have long been associated with a risk of devastating outcomes and intracranial spread. The ...
Water-bolus treatment can help in times of increased orthostatic stress. Patients drink two 8 ounce glasses of cold water ... Most orthostatic headaches have a favorable outcome. POTS patients who manage their symptoms can recognize when their symptoms ... If an EBP is ineffective, surgery is also an option for treatment. A surgical procedure would be customized to the patient ...
Slonim-Nevo, V.; Anson, Y. (1998-06-01). "Evaluating practice: Does it improve treatment outcome?". Social Work Research. 22 (2 ... Her diverse areas of research are: Youth at risk and AIDS prevention; immigration and refugees; polygamy; treatment evaluation ... Slonim-Nevo, Vered (2004). Treatment evaluation: Single-case designs and other methods. Beer Sheva: Ben-Gurion University Press ... treatment evaluation, and integrating diverse interventions for the well-being of individuals and families. The populations ...
... contrasting outcomes between a group of children conditioned to exhibit learned helplessness and a control group. On a ... Gender and Age Disparities for Smoking-Cessation Treatment. American Journal of Preventive Medicine, 30(5), 405-412. http:// ... Pretreatment task persistence predicts smoking cessation outcome. Journal of Abnormal Psychology, 112(3), 448-456. Steinberg, M ...
A six-year outcome study of the treatment of ganglion cysts on the dorsal wrist compared excision, aspiration, and no treatment ... This treatment risks injuring the person and thus is not recommended. Complications of treatment may include joint stiffness ... Surgical treatments remain the primary elective option for treatment of ganglion cysts. The progression of ganglion surgery ... A prospective study of the natural history and patient-reported treatment outcomes". J Hand Surg Br Vol. 28 (2): 172-6. doi: ...
... the Fist Team's more accurately recreated the actual outcome at Gallipoli. At the end of the episode, the Fist Team was the ... still angry about Steve's treatment of them in Episode 9. They inform the team that the website (manifested as an enormous, ...
Mathieu, L. (2003). The emergence and uncertain outcomes of prostitutes' social movements. The European Journal of Women's ... STI treatments, Hepatitis A & B Immunizations, Acupuncture, Massage & Reiki Therapy, Peer and Mental Health Counseling, Support ... health concerns of sex workers outside of STIs and HIV are met with minimal care or insensitive and disrespectful treatment. ... healthcare for sex workers as determined by the community rather than just focusing on HIV and STI prevention and treatment. ...
PIR has a poorer resolution than NIR and this treatment typically focuses on more global increases in cerebral blood flow. The ... Stokes, D.A. & Lappin, M.S.. (2010). Neurofeedback and biofeedback with 37 migraineurs: a clinical outcome study. Behavioral ... The myriad of studies exploring the potency of neurotherapy as a treatment for ASD have primarily involved EEG and QEEG, but ... 70% of sufferers saw a 50% or more reduction in their migraines following combined neurotherapy and drug treatment, as opposed ...
Overall, these and many other events on social media contributed to the outcome of the 2012 election. The Obama campaign in ... "How Social and Traditional Media Differ in Treatment of the Conventions and Beyond". Pew Research Center. 2012-09-26. Retrieved ...
Scholars have coined the term attention economy to refer to the treatment of human attention as a scarce commodity in the ... but has the secondary outcome of blocking or filtering out communities who only have access through cheaper portals." It also ... access to fair treatment and opportunities. In the United States, an AI recruiting tool used by Amazon has shown to ... protection from biased treatment, and equal access to the benefits offered by AI. A 2020 publication by the Berkman Klein ...
... bearing in mind that these outcomes may be partly based on the state of treatment five years ago when the women studied were ... "Cervical Cancer Treatment Options , Treatment Choices by Stage". www.cancer.org. Retrieved 12 September 2020. Baalbergen A, ... cervical cancer treatment. Combination treatment has significant risk of neutropenia, anemia, and thrombocytopenia side effects ... allowing examination and possible preventive treatment, known as colposcopy. The treatment of low-grade lesions may adversely ...
There is no difference, however, in perinatal death or poor outcomes for infants. Below are useful terms on ultrasound: ... Some abnormalities detected by ultrasound can be addressed by medical treatment in utero or by perinatal care, though ... These markers are often not clinically significant and do not cause adverse pregnancy outcomes. Current evidence indicates that ... but this was not a primary outcome of the study, and has been speculated to be due to chance rather than a harmful effect of ...
Comparison of Health Realization and 12-Step Treatment in Women's Residential Substance Abuse Treatment Programs The American ... Many case examples and a modest body of controlled outcome research in solution focused brief therapy (SFBT), have likewise ... Comparison of Health Realization and 12-Step Treatment in Women's Residential Substance Abuse Treatment Programs The American ... Gingerich, W., and Eisengart, S.: Solution-focused brief therapy: A review of the outcome research. Family Process, pp. 477-498 ...
... treatment regimens. The Foundation's role was to convene and facilitate collaboration and dialogue between the CPTR team and a ... Kraft Heinz Margaret Hamburg Mark McClellan Medscape Merck Nestlé Novartis One Medical Group Patient-Centered Outcomes Research ... alternative treatments, or potentially develop a new regulatory tool that would assist in future drug safety evaluation. By ...
Tschopp, Samuel; Tschopp, Kurt (2019). "Tonsil size and outcome of uvulopalatopharyngoplasty with tonsillectomy in obstructive ... "Uvulopalatopharyngoplasty and uvulopalatal flap for the treatment of snoring: Technique to avoid complications". Journal of ...
These treatments, over a period of time, and often over the lifetime of a person, allow that individual and that person's ... Development in neuroimaging techniques has greatly enhanced the scope and outcome of neurorehabilitation. Now, scientists are ... Sparing Treatment must aim at empowering the patient to maximise independence, and to reduce physical impairment and reliance ... Resolving Treatment has to include adequate human and material resources for efficiently resolving each patient's problems as ...
When given within 3 hours, treatment with tpa significantly improves the probability of a favourable outcome versus treatment ... Treatment strategies for brain hypoxia vary depending on the original cause of injury, primary and/or secondary. Mechanism of ... When someone presents with an ischemic event, treatment of the underlying cause is critical for prevention of further episodes ... Hinds CJ (1985). "Prevention and treatment of brain ischaemia". British Medical Journal. 291 (6498): 758-60. doi:10.1136/bmj. ...
These benefits not only include tax-free cash payments but can also include free or low-cost mental health treatment and other ... Regardless of claim outcome, veterans who apply for PTSD disability benefits are highly impaired. However, receiving PTSD ... Murdoch, Maureen (October 1, 2011). "Long-term outcomes of disability benefits in US veterans with posttraumatic stress ... "can bear significantly upon the outcome of the claim for VA benefits.") U.S. Government Accountability Office, Military sexual ...
The negative treatment of overweight and obese individuals may stem from beliefs that weight is controllable and those who fail ... According to the theory, interviews with more richness are expected to result in a better outcome. In general, studies have ... Disparate treatment is defined as intentional discrimination If employers ask about criminal convictions in the interview ... Kohn, Laura S.; Dipboye, Robert L. (May 1998). "The Effects of Interview Structure on Recruiting Outcomes". Journal of Applied ...
The treatment is dependent on the severity of respiratory impairment and the underlying etiology of the disorder. In most cases ... Electrocardiogram is useful in detecting dextrocardia, a possible outcome when agenesis is present on the right lung. With ... If the defect is extensive but there is a chance for the fetus to live, an exo-utero intrapartum treatment (EXIT) may be ... The main focus of the treatment procedure is to preserve the remaining functional tissue and prevent significant ...
Treatment, and Outcomes in Early Stage, Invasive Papillary Breast Cancer: A SEER Investigation of Less Aggressive Treatment in ... Further studies are needed to determine the efficacy of these various treatments as well other treatment regimens for IPC ... treatment in addition to the primary treatment which in this case is surgery) chemotherapy and/or radiotherapy. However, there ... The best treatments for SPC have not been well-defined. Among 265 published cases of SPC, recurrent tumors occurred in 2 cases ...
The AAQ-II scores were found to predict many outcomes, including mental health and work absence rates. The AAQ-II also was ... Treatment, & Recovery. Vol. 1. Thousand Oaks, CA: SAGE Publications. pp. 4-7. ISBN 9781412950848. (Articles with short ... However even when psychological interventions do not explicitly discuss flexibility as an aim of treatment (e.g., behavioral ...
This refers to treatment of religion as an open-ended search. More specifically, it has been seen by Batson as comprising a ... whether they be in individual lives to clarify the outcomes-the fruits, as William James put it-of these phenomena, for ... Leuba argued forcibly for a naturalistic treatment of religion, which he considered to be necessary if religious psychology ... beliefs are increasingly being considered in psychotherapy with the goal of improving service and effectiveness of treatment. A ...
... to develop an effective HG treatment protocol, (3) to eliminate the need to terminate pregnancy due to ineffective HG treatment ... and obstetrics to improve healthcare and outcome for HG sufferers. HER researchers created a registry of women with HG, and has ... "Secular trends in the treatment of hyperemesis gravidarum." American Journal of Perinatology 25.3 (2008): 141-148. Fejzo, ...
"Forensic" means "suitable for use in a court of law", and it is to that standard and potential outcome that forensic ... "the researcher gathered by administering treatments to subjects"; analytical research, which is "based on the act of formally ...
Negligent treatment: a medical professional is alleged to have made a mistake that a reasonably competent professional in the ... care malpractice found that though incidence of negligence in hospitals produced a greater proportion of severe outcomes, the ... A duty was owed: a legal duty exists whenever a hospital or health care provider undertakes care or treatment of a patient. A ... Medical malpractice is professional negligence by act or omission by a health care provider in which the treatment provided ...
... added objectivity to treatment approaches and improved outcomes. The "numerical method" involved the use of averages of groups ... who were unwilling to wait for tests to determine if current treatments were effective, or discard treatments if they were ... Louis acknowledged his own research included too few cases for absolute certainty in the treatment methods, and his student ... He eventually wrote studies on the treatment of tuberculosis and typhoid fever, and produced the "numerical method" for ...
Members of the team work together to create a treatment plan, set goals, educate both the patient and their support network, ... In clinical settings, rehabilitation psychologists apply psychological expertise and skills to improve outcomes for individuals ... Assessment and treatment may include the following areas: psychosocial, cognitive, behavioral, and functional status, self- ... Rath, Joseph F.; Simon, Dvorah; Langenbahn, Donna M.; Sherr, Rose Lynn; Diller, Leonard (2003-09-01). "Group treatment of ...
However, the number of empirical studies on community webs is on the rise and the mathematical treatment of food webs using ... and laws of food web behaviours relative to observable outcomes. "Food web theory centers around the idea of connectance.": ...
The NAPRC's goal is to implement nationwide educational and medical standards for the best treatment of rectal cancer. In 2022 ... A New Scoring System to Evaluate and Predict Outcome of Surgical Intervention". Archives of Surgery. 137 (7): 774-777. doi: ... This score allows for appropriate and consistent diagnosis and treatment. The factors include the frequency and completeness of ... and on racial disparities in colorectal surgery outcomes: Wexner, Steven D.; Nelson, Heidi; Stain, Steven C.; Turner, Patricia ...
The study, published in the New England Journal of Medicine found that treatment with mepolizumab allowed these patients to cut ... research developed in collaboration with clinical activities in order to comprehensively investigate mechanisms and outcomes. ... The Firestone Institute for Respiratory Health (FIRH) is a center for the investigation and treatment of respiratory diseases. ... function and intracellular signalling COPD epidemiology and treatment COPD and Respiratory Rehabilitation Pathobiology of ...
The Herald's forecasted numbers are the medians of all likely outcomes for that party. The sum of the parties' forecasted seats ... Refusals are generally excluded from the party vote percentages, while question wording and the treatment of "don't know" ... Stuff's projected numbers add up to 119, but this outcome is impossible. Calculation (based on exact percentage) shows that ...
Treatment is mainly symptomatic, may require intensive care management but the outcome is uniformly poor and unpredictable if a ... No specific treatment is available as yet. ...
X. How to use an article reporting variations in the outcomes of health services. The Evidence-Based Medicine Working Group. ... How to Use a Treatment Recommendation. JAMA, 281(19), pp. 1836-1843. Available at: http://jama.ama-assn.org/cgi/doi/10.1001/ ...
Outcomes for mothers in childbirth were especially poor before antibiotics were discovered in the 1930s, because of high rates ... The work of Ignaz Semmelweis was seminal in the pathophysiology and treatment of childbed fever and his work saved many lives. ... While some have argued that eating in labour has no harmful effects on outcomes, others continue to have concern regarding the ... They are being studied as possible treatments of a number of conditions. Some animal mothers are known to eat their afterbirth ...
Treatment & Outcomes. *Health Professionals. *Statistics. *More Resourcesplus icon *Mission and Community Service Groups: Be ... Depending on the severity of the infection and the persons immune status, the course of treatment can range from 3 months to 1 ... For some people, the symptoms of histoplasmosis will go away without treatment. However, prescription antifungal medication is ...
ISC 2009: "Counterintuitive" Treatment for IVH Improves Mortality, Functional Outcomes Launch of a Large 500-Patient Trial ... "With this treatment, it ends up having a 17% mortality rate, which is a substantial difference. Yet the treatment is not widely ... The randomized trial will compare outcomes in IVH patients randomized to receive standard treatment with an external ... Cite this: Caroline Cassels . ISC 2009: "Counterintuitive" Treatment for IVH Improves Mortality, Functional Outcomes - Medscape ...
... No Electronic Version ... No significant differences in treatment outcome and deaths were found between the 2 groups. Due to the low frequency of multi- ... In this retrospective study, the drug resistance pattern and outcome of treatment with DOTS category I [‎CAT I]‎ regimen was ... 2012)‎. Drug resistance pattern and outcome of treatment in recurrent episodes of tuberculosis. EMHJ - Eastern Mediterranean ...
... additional approaches to prevention and/or treatment of C. difficile colitis appear to be warranted. ... Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole Clin Infect Dis. 2005 Jun 1;40(11): ... Conclusions: Because of the relatively poor response to therapy, additional approaches to prevention and/or treatment of C. ... Earlier reports have suggested that treatment with metronidazole cured nearly 90% of patients, with only a modest rate of ...
Outcome After Treatment of Pulmonary Aspergilloma Official Title Outcome After Surgical Treatment or Bronchial Embolisation in ... Outcome After Treatment of Pulmonary Aspergilloma. The safety and scientific validity of this study is the responsibility of ... Current Primary Outcome Measures (submitted: October 7, 2013). survival after treatment [ Time Frame: 10 years ]. estimated 10 ... Current Secondary Outcome Measures (submitted: October 7, 2013). post treatment survival [ Time Frame: 90 days ]. survival ...
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U ...
... of rectal cancer has contributed to the widespread use of the technique that enables better treatment selection and outcome for ...
Brain Sagging Dementia-Diagnosis, Treatment, and Outcome. A Review. Aslan Lashkarivand, View ORCID ProfilePer Kristian Eide ... BSD is a newly recognized syndrome mimicking bvFTD with treatment possibilities and cure potential with an excellent outcome. ... The first-line treatment, that is, conservative measures, used in the treatment of SIH should be skipped when treating BSD. In ... Treatment. The traditional conservative treatment regimen usually prescribed for SIH, with hydration, bed rest, caffeine, ...
Henoch-Schönlein purpura (treatment and outcome) Message Subject (Your Name) has sent you a message from Cleveland Clinic ... Treatment and Outcomes. *. Randomized Trial of Cyclophosphamide Versus Methotrexate for Induction of Remission in "Non-Renal" ...
Treatment success, measured by a standardised process of treatment outcome monitoring (TOM), is a key programmatic output of ... Tuberculosis treatment outcome monitoring in European Union countries: systematic review.. Publication. Published. 2013. ... Among the key issues underlined in the action plan is the need to achieve and sustain acceptable levels of treatment success ...
Quantifying womens stated benefit-risk tradeoff preferences for IBS treatment outcomes. Value in Health, 13(4), 418 - 23. ... Whats in a name? A data-driven method to identify optimal psychotherapy classifications to advance treatment research on co- ... Does the relationship between alcohol retail environment and alcohol outcomes vary by depressive symptoms? Findings from a US ...
... addressed this problem in a lecture on immunomodulatory treatment of MS. ... The gold standard for measuring treatment outcomes in multiple sclerosis (MS) is the randomized clinical trial (RCT). However, ... The gold standard for measuring treatment outcomes in multiple sclerosis (MS) is the randomized clinical trial (RCT). However, ... The gold standard for measuring treatment outcomes in multiple sclerosis (MS) is the randomized clinical trial (RCT). However, ...
Patients given their treatment of choice stayed in the program longer and showed fewer symptoms at the end of one study than ... those randomly assigned to treatment that they did not prefer. ... A Patients Choice in Treatment Affects PTSD Outcomes. In This ... why preference played such a big role in treatment outcomes.. "Some of the whys are evident in this data," she says. "One of ... "We need to be able to better match psychiatric treatments to the individual in the future," she says. "The best match is not ...
... allowing you to make better informed treatment decisions and steer your patients towards improved outcomes. ... Treatment Outcome Data. Dominion Diagnostics offers a suite of trend reports based off of aggregated CARD® and SAMM® data. Each ... allowing you to make better informed treatment decisions and steer your patients towards improved outcomes. ... Monitor treatment-related medication adherence and self-reported drug misuse. CARD® "Not Expected" Summary Results by Patient. ...
Psychosocial treatment. Psychosocial treatment, also known as behavioral health treatment, is recommended in conjunction with ... Center for Substance Abuse Treatment, Medication-Assisted Treatment for Opioid Addiction in Opioid Treatment Programs: ... Medication-Assisted Treatment Improves Outcomes for Patients With Opioid Use Disorder Fact Sheet November 22, 2016 Read time: ... Patients receiving psychosocial treatment have better outcomes than patients who do not.9 Common therapeutic goals of ...
Research suggests that cannabis use affects negatively on onset and outcome of schizoph ... Does Cannabis Use Affect Treatment Outcome in Bipolar Disorder?. A Longitudinal Analysis. van Rossum, Inge MSc*; Boomsma, ... The influence of cannabis exposure on clinical and social treatment outcome measures was examined over the course of 1 year, as ... Does Cannabis Use Affect Treatment Outcome in Bipolar Disorder?: A Longitudinal Analysis : The Journal of Nervous and Mental ...
... an algorithm that uses data about tumors to identify new classifications that can provide information about patient outcomes. ... Big data strikes again - subdividing tumor types to predict patient outcome, personalized treatment. A Stanford team has ... Identifying patterns associated with poor patient outcomes could improve a clinicians ability to better tailor treatments to ... But integrating that data into useful treatment plans can still be challenging. ...
Less is known about the effect of providers expectations for those treatments. ... expectations have an impact on the effectiveness of treatments. ... And we found that when the doctors believed that the treatment ... So they had to introduce themselves and then explain what the study was about with the treatment, how the treatment works. And ... ME: What is the main takeaway of your study for primary care doctors? How can they use what you found to improve outcomes in ...
Here, we examine the process and outcomes of TTTF’s implementation within 7 opioid addiction centers. Program goals were ... Taking Texas Tobacco Free (TTTF) is a comprehensive tobacco-free workplace (TFW) program that builds treatment centers’ ... Overall, TTTF may have improved participating opioid treatment centers’ capacity to address tobacco use, although study ... gain in tobacco control and treatment knowledge (p < 0.0001), and significant increases in exposure to education about ...
Does Dietary Folate Intake Modify Treatment-related Toxicity or Disease Outcome Among Children with Acute Lymphoblastic ... folate may play in the effectiveness and side effects of an anti-folate chemotherapy drug both during and after treatment. ...
First, to evaluate the long-term outcome of anti-vascular endothelial growth factor (anti-VEGF) treatment in a clinical setting ... Results: VA improved initially after year one of treatment. VA decreased in the subsequent four years of treatment, but ... Patients started treatment with monthly injections of either bevacizumab (1.25 mg/0.05 mL) or ranibizumab (0.5 mg/0.05 mL) ... In some patients the first treatment was replaced with aflibercept (2 mg/0.05 ml). Participants: On the basis of the inclusion ...
Outcome of community-acquired pneumonia: influence of age, residence status and antimicrobial treatment. H. Kothe, T. Bauer, R. ... Previous studies on the impact of initial treatment on outcome have focused on critically ill patients 14, 15, 33 and patients ... Indeed, some data in the literature suggest that treatment conforming to guidelines is associated with a better outcome 36, 37 ... Outcome of community-acquired pneumonia: influence of age, residence status and antimicrobial treatment ...
Does pre-operative multifidus morphology on MRI predict clinical outcomes in adults following surgical treatment for ... Does pre-operative multifidus morphology on MRI predict clinical outcomes in adults following surgical treatment for ... Does pre-operative multifidus morphology on MRI predict clinical outcomes in adults following surgical treatment for ... Clinical and outcome variables. The aim of this review was to identify the longitudinal association between pre-operative ...
Drug Courts and State Mandated Drug Treatment Programs: Outcomes, Costs and Consequences. ... The findings show that the Drug Court model had greater success at producing higher rates of treatment completion and lower ... Data on program resources, outcomes, and their costs were obtained from a study preformed before the implementation of SACPA in ... offering treatment for their substance abuse without incarceration. SACPA programs have had a much larger impact on the masses ...
Similar proportions of patients with SIBO improved whether or not they received antibiotic treatment, calling into question the ... and the clinical outcomes of patients identified by this method. In a retrospective study, we analyzed electronic medical ... Duodenal Aspirates for Small Intestine Bacterial Overgrowth: Yield, PPIs, and Outcomes after Treatment at a Tertiary Academic ... Patients were divided into two groups according to documented clinical outcomes after primary treatment (i.e., antibiotics). ...
... , Training ... Predictors of Treatment Outcome In Parent Training For Families With Conduct Problem Children. ... There is a need to bolster the impact of parent training programs both by lengthening their treatment programs and by providing ...
Spoken Language Outcome Measures for Treatment Studies in Down Syndrome: Feasibility, Practice Effects, Test-Retest Reliability ... Sterling, PhD, A. Spoken Language Outcome Measures for Treatment Studies in Down Syndrome: Feasibility, Practice Effects, Test- ... Spoken language outcome measures for treatment studies in Down syndrome: feasibility, practice effects, test-retest reliability ... Spoken language outcome measures for treatment studies in Down syndrome: feasibility, practice effects, test-retest reliability ...
How Bladder Cancer Can Help Change Patient Treatment Outcomes. September 9, 2022 ... The Comparison of Intravesical Therapy and Surgery as Treatment Options (CISTO). *Black and African-Descent Collaborative for ... The Comparison of Intravesical Therapy and Surgery as Treatment Options (CISTO). *Black and African-Descent Collaborative for ...
  • The randomized trial will compare outcomes in IVH patients randomized to receive standard treatment with an external ventricular drain (EVD) or an EVD plus tPA. (medscape.com)
  • In order to be a candidate for treatment, patients had to have 2 consecutive computed tomography (CT) scans demonstrating that the bleeding had stopped and the clot had stabilized within 6 hours after catheter placement. (medscape.com)
  • Earlier reports have suggested that treatment with metronidazole cured nearly 90% of patients, with only a modest rate of recurrence of infection. (nih.gov)
  • Outcome analysis of all surgically treated patients for a confirmed invasive aspergilloma. (clinicaltrials.gov)
  • His thesis on MRI (magnetic resonance imaging) of rectal cancer has contributed to the widespread use of the technique that enables better treatment selection and outcome for these patients. (ki.se)
  • Among the key issues underlined in the action plan is the need to achieve and sustain acceptable levels of treatment success among all TB patients. (kit.nl)
  • One assessment of the trial, which compared different reactions to interferon beta exposure among treated and untreated patients, presented opposite outcomes between the contemporary, untreated cohort, and the historical cohort. (ajmc.com)
  • If you include these patients as events in the comparison," Sormani said, "the difference becomes in favor of treatment. (ajmc.com)
  • Yet research suggests that allowing patients to choose their treatment can improve how well they respond to it. (dana.org)
  • Shared medical decision-making, a process in which clinicians and patients work together to make medical decisions, including deciding on treatment plans, using clinical evidence and the patient's preferences, is one way to do just that. (dana.org)
  • In situations where patients are part of this process, research indicates that it can improve health outcomes for patients," she says. (dana.org)
  • Second, when they do feel engaged in this way, patients are much more likely to be compliant and adhere to a particular treatment regimen. (dana.org)
  • Each was asked state a preference for treatment: a medication-based approach, the drug Sertaline (better known as Zoloft), or a behavioral therapy known as prolonged exposure therapy, where patients are asked to gradually approach traumatic memories in order to better process them. (dana.org)
  • The reports provide information that is both accurate and actionable, allowing you to make better informed treatment decisions and steer your patients towards improved outcomes. (dominiondiagnostics.com)
  • Patients receiving psychosocial treatment have better outcomes than patients who do not. (pewtrusts.org)
  • An independent impact of cannabis use on psychopathologic outcomes in patients with bipolar disorder was apparent, whereas the impact on social outcomes was modest. (lww.com)
  • By classifying patients into these subtypes, we can predict their chance of survival and their likelihood of relapse after treatment. (stanford.edu)
  • Identifying patterns associated with poor patient outcomes could improve a clinician's ability to better tailor treatments to individual patients, the researchers said. (stanford.edu)
  • By studying the biological characteristics that are defining different subtypes, we could potentially develop personalized treatments to improve the care of patients. (stanford.edu)
  • Doctors know that patients' expectations have an impact on the effectiveness of treatments. (medicaleconomics.com)
  • Doctors have long known that patients' expectations have a significant impact on the effectiveness of treatments prescribed for them. (medicaleconomics.com)
  • Then we explained to the doctors that we're interested in studying simulated clinical interactions, and that they'd be administering a treatment to the patients. (medicaleconomics.com)
  • Surgery is the mainstay of treatment in canine mammary tumors and can be curative in patients with benign tumors, low grade histology or early stage disease (small tumors). (vin.com)
  • First , to evaluate the long-term outcome of anti-vascular endothelial growth factor (anti-VEGF) treatment in a clinical setting using the "treat-and-extend regimen" (TER) in patients with neovascular age-related macular degeneration (nAMD). (frontiersin.org)
  • We conducted a single center retrospective review of patients with treatment-naive nAMD who were treated with anti-VEGF. (frontiersin.org)
  • Patients started treatment with monthly injections of either bevacizumab (1.25 mg/0.05 mL) or ranibizumab (0.5 mg/0.05 mL) until there were no signs present of choroidal neovascularization (CNV) activity. (frontiersin.org)
  • In some patients, the first treatment was replaced with aflibercept (2 mg/0.05 mL). (frontiersin.org)
  • TER with anti-VEGF for nAMD treatment prevents long-term severe visual loss in real-world setting and maintains patients' VA at levels sufficient to ensure independence. (frontiersin.org)
  • However, the impact of treatment failure in nonselected CAP patients is not clear. (ersjournals.com)
  • In contrast, in a recent study in elderly CAP patients, the necessity of changing initial therapy was not associated with an unfavourable outcome 7 . (ersjournals.com)
  • We aimed to determine the yield of SIBO-positive cultures detected in duodenal aspirates, the relationship between SIBO and PPI use, and the clinical outcomes of patients identified by this method. (hindawi.com)
  • Similar proportions of patients with SIBO improved whether or not they received antibiotic treatment, calling into question the use of this expensive therapy for this disorder. (hindawi.com)
  • We sought to evaluate a cohort of patients undergoing EGD with duodenal aspirates to determine the diagnostic yield of cultures, clinical response to antibiotic treatment and the risk factors associated with SIBO. (hindawi.com)
  • Minimally invasive surgical treatment of intracranial meningiomas in elderly patients (≥ 65 years): outcomes, readmissions, and tumor control. (bepress.com)
  • 65 years versus 118 patients ≥ 65 years old, there were no significant differences in tumor location, size, or outcomes. (bepress.com)
  • CONCLUSIONS: This analysis suggests that elderly patients with meningiomas, when carefully selected, generally have excellent surgical outcomes and tumor control. (bepress.com)
  • In patients successfully treated for peri-implantitis, an individualized supportive care program, including professional and self-performed biofilm removal at implants and teeth, is associated with positive medium- to long-term outcomes. (iti.org)
  • The respective companies currently market oral diabetes, insomnia, rheumatology and gastroenterology treatments and seek to bring innovative products to patients through a pipeline that includes compounds in development for diabetes, cardiovascular disease, gastroenterology, neurology and other conditions. (takeda.com)
  • MRgFUS is a new, non-invasive treatment modality that can provide alternatives for patients with essential tremor who do not desire surgical treatment. (cns.org)
  • Sixty-four consecutive cases of hepatic abscess diagnosed over a 6-year period and all treated by ultrasound-guided percutaneous needle aspiration and systemic antibiotics were retrospectively reviewed to ascertain factors influencing the outcome in these patients. (annals.edu.sg)
  • This study compares treatment outcome, dropouts, ED psychopathology and personality characteristics for 20 individuals with ED and T1DM and 20 ED patients without diabetes, matched for diagnostic and treatment type. (biomedcentral.com)
  • The low levels of motivation to change, and insulin abuse in T1DM patients, may suggest that treatment for patients with ED and T1DM should consider the individual's personality and role of insulin abuse when determining the appropriate intervention. (biomedcentral.com)
  • Providing your patients treatment outcomes makes your performance transparent and builds trust. (eye-tech-solutions.com)
  • The aim of this study was, early in the treatment phase, to identify patients with advanced head and neck cancer, responding or not responding to initiated therapy. (lu.se)
  • The differences in treatment patterns between older and younger patients were explored and the impact of age, patient and disease characteristics on survival outcomes was assessed. (oncotarget.com)
  • Similar survival benefit from treatment was seen in older and younger patients. (oncotarget.com)
  • Mass General's outcomes are as expected, given the high number of very ill and extremely complex patients we serve, as compared to the Society of Thoracic Surgeons (STS) norms. (massgeneral.org)
  • Background To identify prognostic factors and define the optimal management of patients with supratentorial primitive neuroectodermal tumors (sPNETs), we investigated treatment outcomes and explored the prognostic value of specific molecular markers. (elsevier.com)
  • Conclusions We found that multimodal treatment improved outcomes for sPNET patients, especially when radiotherapy and ≥subtotal resection were part of the treatment regimen. (elsevier.com)
  • MRD refers to a small number of cancer cells that remain in the body following medical treatment, which can lead to relapses in patients. (personalis.com)
  • Additionally, patients at later stages of cancer development may still require diagnostic testing to determine their health status near the end of their treatment plan. (personalis.com)
  • Methods: Included were 51 patients (31 males, 20 females), who underwent elective FURS, for the treatment of kidney stones. (openrepository.com)
  • Medical therapy in patients with complete AVSDs consists of aggressive anticongestive treatment for the signs and symptoms of congestive heart failure (CHF). (medscape.com)
  • Factors for a favorable outcome in patients who undergo repair of complete AVSD appear to include younger patient age and better preoperative common AV valve function. (medscape.com)
  • They also wished to expand the existing research base by comparing these outcomes with those of HIV-positive kidney transplant patients who had an HIV-negative donor. (aidsmap.com)
  • Improving the diagnostic accuracy of STEC infection by clinical laboratories should ensure prompt diagnosis and treatment of these infections in patients and increase detection of STEC outbreaks in the community. (cdc.gov)
  • All patients (6 of 7) who received I131 dose of 100 microCi/g of thyroid tissue required more than a single dose of I131 treatment. (who.int)
  • Further outcome in fifteen patients (46.9%) is yet to be followed. (who.int)
  • They also looked at an 18-gene signature that has been found in patients with metastatic disease to be associated with a good outcome, when patients are treated with PD-1 antibodies. (medscape.com)
  • The investigators found that in the resected tumors in patients with stage III disease, that same 18-gene signature was very closely associated with a good outcome. (medscape.com)
  • The objective of the study was to investigate psychological profile changes of patients from a TC, who were assessed in the beginning and in the end of treatment. (bvsalud.org)
  • This study aimed to compare patient outcomes with regards to clinically relevant postoperative pancreatic fistula (CR-POPF) and other postoperative complications among patients receiving traditional anastomosis, classical Blumgart anastomosis, and our modified-Blumgart anastomosis. (medscimonit.com)
  • Concerning the outcome, 56% and 6.9% of patients with and without life-threatening injuries respectively, died. (who.int)
  • This study determined the outcomes of COVID-19 among patients with comorbidities in Kaduna state , where we have the highest incidence in northern Nigeria . (bvsalud.org)
  • Most patients with comorbidities had severe presentations and fatal poorer outcome. (bvsalud.org)
  • Ikuta K, Tono O, Oga M. Clinical outcome of microendoscopic posterior decompression for spinal stenosis associated with degenerative spondylolisthesis--minimum 2-year outcome of 37 patients. (medscape.com)
  • The European Transplant Allied Healthcare Professionals (ETAHP) reaches out to allied healthcare professionals throughout Europe in order to ensure the best care possible for all transplant patients, with the aim to optimize patient outcomes. (esot.org)
  • ECTTA is the forum for experience exchange on treatment of patients with end-stage heart and lung failure. (esot.org)
  • Our aim is to improve outcomes for the patients. (esot.org)
  • A registry with patient characteristics, treatments, and outcomes of cancer patients. (jpain.org)
  • The Memorial Sloan Kettering Pain Registry contains patient characteristics, treatments, and outcomes for a prospective cohort of 1,534 chronic pain cancer patients who were seen at outpatient pain service clinics. (jpain.org)
  • Spark the scientific breakthroughs that innovate treatments to improve the lives of patients. (pancan.org)
  • Pancreatic cancer patients who participate in clinical research have better outcomes. (pancan.org)
  • Overview Oversees the medical care and treatment of Hospice patients and provides direction and guidance to the staff and volunteers to assure quality care. (jobserve.com)
  • We teach other specialists to recognize and evaluate patients with suspected vasculitis early so they can receive timely treatment. (uclahealth.org)
  • For all forms of TB, 19% of patients were lost to follow-up from treatment. (who.int)
  • S2 Episode 3: Psychiatric Comorbidities and Schizophrenia Drs John M. Kane and Christoph U. Correll discuss the importance of ongoing assessment of psychiatric comorbidities in patients with schizophrenia and its impact on outcomes and treatment decisions. (medscape.com)
  • A novel TMS protocol is being hailed as a revolutionary treatment for patients with the severest depression. (medscape.com)
  • Chi-square test was conducted to compare proportions for the modes of detection and treatment outcomes among Japan- and foreign-born patients. (who.int)
  • Does pre-operative multifidus morphology on MRI predict clinical outcomes in adults following surgical treatment for degenerative lumbar spine disease? (springer.com)
  • The clinical outcomes were documented by either the referring physician or gastroenterology consultant or self-reported by the patient in telephonic communication with the healthcare team. (hindawi.com)
  • The likely outcome of the disease or chance of recovery is called prognosis. (cancer.gov)
  • We hypothesized that clinical characteristics and treatment techniques may affect the prognosis of teeth with cemental tears . (bvsalud.org)
  • They come into treatment very late in the disease, and their rate of aggressive, triple-negative breast cancer-the subtype with the poorest prognosis-is higher than in other racial groups. (medlineplus.gov)
  • Asked by Medscape Neurology & Neurosurgery to comment on the study, Cheryl Bushnell, MD, an assistant professor of neurology at Wake Forest University Health Sciences, in Winston-Salem, North Carolina, said the findings offer hope for better patient outcomes. (medscape.com)
  • The more precise and early we can determine the efficacy of different treatments, the more able we'll be to advise on the combinations of treatments that a particular patient needs. (ki.se)
  • Recognizing this condition is essential to provide early treatment to reverse the cognitive and behavioral changes that may otherwise progress and fully impair the patient. (neurology.org)
  • After struggling to diagnose a patient with complex symptoms, a doctor will mandate a particular treatment-and, lo and behold, the patient recovers. (dana.org)
  • Consistent with the approach used for other chronic diseases such as diabetes, treatment plans for OUD are patient specific and created with input from the patient, the prescriber, and other members of the health care team. (pewtrusts.org)
  • This dual approach to OUD treatment is supported by medical and behavioral health groups, including the American Society of Addiction Medicine and the National Council for Behavioral Health, patient advocate groups, and federal entities including the White House Office of National Drug Control Policy and the U.S. surgeon general. (pewtrusts.org)
  • 10 Psychosocial treatment begins with an assessment of a patient's psychosocial needs and the development of a patient-specific treatment plan. (pewtrusts.org)
  • And to-date, most of the studies have been on the patient side, about how their beliefs influence their own outcomes. (medicaleconomics.com)
  • But the key part was they couldn't tell the patient which treatment was which. (medicaleconomics.com)
  • And we found that when the doctors believed that the treatment was the real treatment, the patient reported experiencing less pain. (medicaleconomics.com)
  • One is just your overall physiological arousal, and for that we measured skin conductance while they were receiving the pain and found that the patient had lower arousal levels when the doctors believed the treatment was real. (medicaleconomics.com)
  • Apart from host-derived factors, the appropriateness of initial antimicrobial treatment has been shown to influence outcome in patient populations with severe disease, such as ventilator-associated pneumonia 14 and severe CAP 15 . (ersjournals.com)
  • The Patient Centered Outcomes Research Institute, or PCORI, has begun the process of implementing its mission to help consumers make better informed decisions on their health care through the funding of patient-centered comparative clinical effectiveness research. (actuary.org)
  • Prompt, accurate diagnosis of STEC infection is important because appropriate treatment early in the course of infection might decrease the risk for serious complications such as renal damage and improve overall patient outcome. (cdc.gov)
  • Opioid use and dosage are essential to understand patient reported outcomes. (jpain.org)
  • Psychoanalytic treatment in its classical form makes use of the technique of free association, which requires the patient to say whatever comes to mind. (dissidentvoice.org)
  • Using incident reports to assess communication failures and patient outcomes. (ahrq.gov)
  • Dental trauma guidelines provide specific recommendations and protocols to ensure the best positive patient outcomes. (bvsalud.org)
  • addresses the transition out of this state and is fundamental to the patient-clinician relationship, guiding decisions about treatment. (cdc.gov)
  • A cholera case patient was defined as someone who passed about 3 liquid stools with or without vomiting or dehydration in the previous 24 hours or within 6 hours of seeking treatment. (cdc.gov)
  • Unable to follow-potentially toxic - The patient was lost to follow-up, refused follow-up, or was not followed, but the exposure was significant and may have resulted in a moderate or major outcome or death. (cdc.gov)
  • The following chart shows the Pulmonary Resection Outcomes from July 2016 to June 2019. (massgeneral.org)
  • Response to Initial Immunotherapy Treatment Predicts Melanoma Outcomes - Medscape - Sep 11, 2019. (medscape.com)
  • Conclusion: PK-guided dose adjustments of 5-FU and Docetaxel in DPF regimen can significantly decrease the treatment related side effects and mortality without compromising the tumor response rate. (scirp.org)
  • If successful, treatments such as surgery and chemotherapy can debulk or decrease tumor volumes to levels that are too small for biopsy. (personalis.com)
  • The TIL cells included so-called exhausted T cells, which were CD8- positive, PD- 1-positive, CTLA4- positive cells that proliferated significantly, both in the tumor and in the periphery after treatment. (medscape.com)
  • This includes the tumor grade and type, traits of the cancer, the person's age and health when diagnosed, and how they respond to treatment. (cancer.gov)
  • Treatments are decided by the patient's healthcare team based on the patient's age, remaining tumor after surgery, tumor type, and tumor location. (cancer.gov)
  • Atypical Teratoid Rhabdoid Tumor (ATRT) Diagnosis and Treatment was originally published by the National Cancer Institute. (cancer.gov)
  • In very young children, the tumor may go away on its own, without treatment. (medlineplus.gov)
  • Rehabilitation is critical for improving functional recovery, and was shown to reduce hospital readmissions, as well as all-cause and cardiovascular mortality and stroke recurrence (long-term outcomes), but spasticity (occurring in 30% of stroke survivors) may prevent effective recovery. (ispor.org)
  • The goal was to model the clinical and economic effects of ABoNTA treatment on long-term outcomes in PSS. (ispor.org)
  • Effects of ABoNTA on functional outcomes such as the Functional Independence Measure (FIM), and the impact of functional outcomes on long-term outcomes, were estimated from literature review and meta-analyses. (ispor.org)
  • A model was developed based on associations between ABoNTA, functional, and long-term outcomes. (ispor.org)
  • Latent or delayed complications do not develop after treatment. (cns.org)
  • Without treatment, it can lead to serious complications, such as a stroke. (uclahealth.org)
  • Dr Sormani shared findings on the inadequacy of randomized clinical trials (RCT), and highlighted the limitations of both observational studies and long-term follow ups as methods of assessing long-term effects of MS treatment. (ajmc.com)
  • No images have been falsified or manipulated to misrepresent treatment outcomes.The educational objectives, content, and selection of educational methods and instructors are conducted independent of any commercial entity. (ihs.gov)
  • Comparing the outcomes of reporting and trigger tool methods to capture adverse events in the emergency department. (ahrq.gov)
  • Unlike other respiratory diseases for which there are significant published data on racial and ethnic disparities in disease outcomes, such information is notably lacking in the COPD literature. (nih.gov)
  • One of the reasons I came to NCI as a breast oncologist was to be able to look at racial disparities and see the differences in risk, screening, treatment, and survivorship. (medlineplus.gov)
  • Our objective was to identify cases of BSD in the literature and present its clinical characteristics, diagnostic workup, treatment options, and outcome. (neurology.org)
  • We offer diagnostic and treatment options for common and complex medical conditions. (massgeneral.org)
  • We create personalized care plans using state-of-the-art diagnostic tools and treatment options. (uclahealth.org)
  • We develop new diagnostic tools, research treatments and track outcomes. (uclahealth.org)
  • For some people, the symptoms of histoplasmosis will go away without treatment. (cdc.gov)
  • Being aware of its signs and symptoms is essential for early diagnosis and treatment in this potentially reversible form of dementia. (neurology.org)
  • With treatment, 81% experienced partial and 67% complete resolution of their symptoms. (neurology.org)
  • Youths completed measures of eating disorder symptoms, including muscularity concerns, and other psychiatric symptoms at baseline and end of treatment. (researchsquare.com)
  • I have had three sudden-onsets of symptoms, in June 2018, May 2020 and January 2021, all with various psychological and neurological symptoms which have resulted in numerous diagnoses but which have all been treatment-resistant, with medications giving terrible side effects. (latitudes.org)
  • Basically, from this, I was wondering if I have to have another sudden-onset of symptoms in order to receive treatment (and be tested diagnosed, although I know that some doctors will diagnose off of medical history), or if I can receive treatment now? (latitudes.org)
  • Early diagnosis and treatment improves the chance of a good outcome. (medlineplus.gov)
  • Clinical diagnosis and treatment of cemental tears should also consider the apicocoronal location and the type of treatment technique to improve outcomes. (bvsalud.org)
  • The emergency workers may take you to a specialized stroke center to ensure that you receive the quickest possible diagnosis and treatment. (cdc.gov)
  • Measures to ensure early diagnosis and treatment adherence should be adapted to such populations. (who.int)
  • Outcome After Surgical Treatment or Bronchial Embolisation in Aspergilloma of the Lung: a Single Center Experience. (clinicaltrials.gov)
  • This systematic review found evidence for an association between low multifidus fat infiltration on MRI at baseline and greater reductions in measures of LBP and disability following surgical treatment. (springer.com)
  • Results: 'C-AT' and 'nC-AT' participants significantly outperformed controls pre-to-post to 3-months post-treatment in both assessment contexts. (editlib.org)
  • Outcome assessment found that 51.5% (17/33), 42.4% (14/33), and 6.1% (2/33) of teeth were classified as healed, questionable, and failed, respectively. (bvsalud.org)
  • Learners are provided with a comprehensive and inter-professional approach to client: identification, assessment, treatment, documentation and discharge planning for those impacted by RMW. (ciaoseminars.com)
  • Betsy enjoys an interdisciplinary approach to Cardiopulmonary assessment and treatment. (ciaoseminars.com)
  • Discipline specific assessment and treatment tools. (ciaoseminars.com)
  • Tuberculosis treatment outcome monitoring in European Union countries: systematic review. (kit.nl)
  • We concluded that basic hearing loss prevention programs provide superior outcomes to no systematic hearing loss prevention education, and that benefits from comprehensive hearing loss prevention education were observable within the 7th grade group 9 to 12 months following the start of the intervention. (cdc.gov)
  • We report the first results of HIV-positive donor to HIV-positive recipient kidney transplantation in the United States, and directly compare outcomes in HIV-positive recipients of HIV-negative donor kidneys to evaluable attributable risk of HIV-positive donors," write the authors. (aidsmap.com)
  • In spite of this, current treatments for individuals with ED do not vary depending on whether the person suffers from T1DM or not, although the clinical and personality characteristics may differ. (biomedcentral.com)
  • In this Care Cues, experts discuss how shared decision-making can improve adherence to therapy and optimize outcomes. (medscape.com)
  • Therefore, a prospective multicentre study was conducted in order to assess risk factors influencing CAP mortality, with a special emphasis on age, residence status, underlying conditions and antimicrobial treatment. (ersjournals.com)
  • To address the gaps in the literature examining eating disorders among males and gender minority youths, a prospective study was designed to assess gender differences in eating disorder symptom presentation and outcomes. (researchsquare.com)
  • Because of the relatively poor response to therapy, additional approaches to prevention and/or treatment of C. difficile colitis appear to be warranted. (nih.gov)
  • 1 Medication-assisted treatment (MAT)-a combination of psychosocial therapy and U.S. Food and Drug Administration-approved medication-is the most effective intervention to treat opioid use disorder (OUD) and is more effective than either behavioral interventions or medication alone. (pewtrusts.org)
  • There is a need to bolster the impact of parent training programs both by lengthening their treatment programs and by providing ongoing expanded therapy which focuses on families' specific needs such as life crisis management, depression, problem-solving, budget planning, marital therapy, and so forth. (incredibleyears.com)
  • PDF] Acceptance and Commitment Therapy modules: Differential impact on treatment processes and outcomes. (semanticscholar.org)
  • Acceptance and Commitment Therapy offered in a group appears a promising treatment for those with psychosis and history of trauma, and participants' ability to regulate their emotional reactions increased. (semanticscholar.org)
  • Assessing Treatment Integrity in Acceptance and Commitment Therapy: Strategies and Suggestions. (semanticscholar.org)
  • The study found higher dropout rates from therapy in individuals with T1DM and worse treatment outcome in spite of having no significant differences in eating disorder psychopathology, although individuals with T1DM report misusing insulin. (biomedcentral.com)
  • The development of alternative treatment regimens in clinical oncology has increased the need for early prediction of cancer therapy outcome. (lu.se)
  • Clinical trials, with new chemotherapy, targeted therapy, or immunotherapy drugs, may also be available and can be a possible treatment option. (cancer.gov)
  • In treatment and care, Zambia has managed to reach more than 50 % coverage of antiretroviral therapy (ART). (who.int)
  • Even those who were initially more severely disabled continued to improve months after treatment, with the majority scoring lower on disability assessments after 6 months compared with the same assessments taken at 30 days. (medscape.com)
  • Blind assessments of outcomes were completed pre-, post-, and 3-months post-treatment in a formal and informal context. (editlib.org)
  • Patterns of drug resistance in recurrent cases of tuberculosis may be different than in those without a history of treatment. (who.int)
  • Childhood morbidity and treatment patterns / Shane Ryland, Hendrik Raggers. (who.int)
  • For the current study, data on program, outcome, and cost were collected from administrative databases and paper files on a cohort of drug court participants after SACPA implementation (those entering the program in 2002-2003), as well as on a cohort of SACPA participants who enrolled in the program during the same time period. (ojp.gov)
  • Comparison of cardiovascular events among treatments for overactive bladder: a Danish nationwide cohort study. (rti.org)
  • While the short-term efficacy of a treatment can be seen through MRI activity and clinical activity, long-term effectiveness can be manipulated by several interventions in the patient's course of disease. (ajmc.com)
  • The influence of cannabis exposure on clinical and social treatment outcome measures was examined over the course of 1 year, as well as the effects on these associations of third mediating variables. (lww.com)
  • Pre- and peri-operative clinical information, physiological observations and outcome measures following flexible ureterorenoscopy (FURS), for the treatment of kidney stones. (openrepository.com)
  • The main aim of this clinical-pilot study was to investigate the effect of flexible ureterorenoscopy (FURS) on pre- and peri-operative clinical information, physiological observations and outcome measures. (openrepository.com)
  • Pre-operative and peri-operative clinical information, and post-operative physiological observations and outcome measures were collected using a standard case report form. (openrepository.com)
  • If there is no statistical difference between treatments (and you have verified that enough participants were included to achieve the power needed to find a difference if one existed and that extreme variability in the data caused by poor outcome measures or a poorly selected subject group didn't impact the ability to see a difference), then you can proceed confidently knowing that these two particular treatments aren't different. (cdc.gov)
  • But integrating that data into useful treatment plans can still be challenging. (stanford.edu)
  • Data on program resources, outcomes, and their costs were obtained from a study preformed before the implementation of SACPA in California (1998-1999). (ojp.gov)
  • With this web-based database you can capture refractive treatment data quickly and precisely, and present it graphically for all sorts of uses in daily clinical work. (eye-tech-solutions.com)
  • A retrospective analysis of data was made to study 6 different public-private mix models for TB control in Pakistan and estimate the contribution of the various private providers to TB case notification and treatment outcome. (who.int)
  • Thirty-six were excluded from analysis: 33 lacked fetal outcome data and 3 died. (cdc.gov)
  • In terms of published and presented data, we generally encounter treatments that have been found to be significantly different. (cdc.gov)
  • The health outcome data groupings are defined by the AAPCC. (cdc.gov)
  • I am also encouraged that these women are joining the trials, because data suggest early treatment is more effective, especially for aggressive cancers. (medlineplus.gov)
  • The medical records were then reviewed to document the results of duodenal aspirates and any subsequent clinical notes to document therapeutic intervention and its outcomes. (hindawi.com)
  • The therapeutic community (TC) is a treatment modality for substance abusers applied in Brazil. (bvsalud.org)
  • Does Cannabis Use Affect Treatment Outcome in Bipolar Disorder? (lww.com)
  • All male youths who presented for specialized eating disorder treatment at one of two sites were invited to participate, along with a group of matched females, and all youths who did not identify with the sex assigned to them at birth. (researchsquare.com)
  • Males demonstrated greater eating disorder symptom improvements than females, suggesting that male adolescents may have better treatment outcomes than females in some domains. (researchsquare.com)
  • Further, use of a 'C-AT' program may be another feasible treatment method for this disorder population. (editlib.org)
  • Psychoanalytic theory views mental disorder as the outcome of unconsciously determined symbolic efforts that only partially resolve these intrapsychic conflicts, resulting in pathological adjustments to the vicissitudes of psychosexual development. (dissidentvoice.org)
  • As observational studies seek to compare treated to untreated cohorts, those comparisons are distorted by such factors as selection bias, start-time of treatment, and immortal time bias. (ajmc.com)
  • There is much discrepancy in the literature regarding factors influencing the outcome in the elderly population. (ersjournals.com)
  • Objective: Primarily to understand whether clinically relevant factors affect the International Outcome Inventory (IOI-HA) scores and to examine if IOI-HA scores improve when renewing the hearing aids (HA) for experienced users. (aau.dk)
  • Several factors must be considered to reach an acceptable outcome in nasal reconstruction. (medscape.com)
  • In addition to further research, evidence-based action is needed to prevent exposure to criminogenic factors for Black people and to address the inequitable treatment of Black people within the criminal justice system. (ices.on.ca)
  • The importance of treatment guidelines is to provide guidance on what to expect, what the expected outcomes are based on the injury, the different factors related to that injury, along with a clear recommendation about the immediate treatment specifically to the type of injury. (bvsalud.org)
  • Interventions for sexual behavior problems that have been systematically evaluated predominately fall in one of two categories: (a) treatments targeting sexual behavior problems and (b) treatments targeting the effects of child sexual abuse including sexual behavior problems. (cebc4cw.org)
  • Countries in the African Region have made remarkable progress in implementing various elements of HIV/AIDS prevention, treatment and care interventions during the last three-to-four years. (who.int)
  • This panel discussion is organized to enable country delegations to share experiences and lessons learned in scaling up some HIV/AIDS prevention, treatment and care interventions. (who.int)
  • The results show improvements in psychological functioning in different degrees for two subgroups of participants in the end of treatment, in terms of their personality structure type. (bvsalud.org)
  • Adoption of the Kidney Disease Improving Global Outcomes (KDIGO) practice guidelines is reasonable for reduction of CSA-AKI risk in adults undergoing cardiac surgery with CPB who are at high risk for AKI. (medscape.com)
  • In this retrospective study, the drug resistance pattern and outcome of treatment with DOTS category I [‎CAT I]‎ regimen was compared in 63 recurrent cases and 872 new cases of pulmonary tuberculosis from April 2003 to January 2008 at the National Research Institute of Tuberculosis and Lung Disease in Tehran, Islamic Republic of Iran. (who.int)
  • A low population-screening rate, a high proportion of pulmonary TB cases without sputum test results and a low treatment success rate suggest areas for improvement in the National TB Program. (who.int)
  • Changes in the morphology of the lumbar multifidus muscle on magnetic-resonance imaging (MRI) are associated with worse LBP and disability, but the association between multifidus morphology and post-operative outcomes is not known. (springer.com)
  • Shared Decision-Making in Heart Failure Heart failure treatment can significantly affect a patient's quality of life. (medscape.com)
  • and determined the impact of statewide mandated treatment policy reform on the operation of drugs courts in California, with attention to the implementation of the Substance Abuse and Crime Prevention Act of 2009 (SACPA). (ojp.gov)
  • 5 allows us to reach millions of people globally with accurate and reliable resources about HIV prevention and treatment. (aidsmap.com)
  • Outcomes, measured 9 to 12 months after the start of the intervention, included changes in hearing status, self-reported exposure frequency, knowledge, health beliefs, and intentions regarding hearing loss prevention. (cdc.gov)
  • No significant differences in treatment outcome and deaths were found between the 2 groups. (who.int)
  • and to identify differences in treatment outcomes between the groups. (biomedcentral.com)
  • No significant differences in treatment gains were found between 'C-AT' and 'nC-AT. (editlib.org)
  • For the clinician, statistical significance can be considered the first step in interpreting differences between treatments. (cdc.gov)
  • After all, most treatment studies are designed to find differences that promote a particular new technology or signal processing scheme. (cdc.gov)
  • No significant differences in hearing sensitivity were observed across the basic and comprehensive treatment groups. (cdc.gov)
  • Why are there continued differences among racial groups in breast cancer outcomes? (medlineplus.gov)
  • Search for condition information or for a specific treatment program. (massgeneral.org)
  • After exposure to sulfur dioxide, without pre-treatment, the mean decrease in forced expiratory volume in one second was .12L. (cdc.gov)
  • Pre-treatment with ipratropium bromide resulted in a minimized sulfur dioxide-induced response (mean decrease =.04L). (cdc.gov)
  • or = 10 days despite treatment, and 58 (28%) responded initially but had a recurrence within the ensuing 90 days. (nih.gov)
  • Dr. Kelly investigated the role dietary folate may play in the effectiveness and side effects of an anti-folate chemotherapy drug both during and after treatment. (aicr.org)
  • People with ATRTs usually receive further treatments after surgery, which may include radiation , chemotherapy or clinical trials . (cancer.gov)
  • The most worrying part is, while he is on treatment and the outcome of chemotherapy once it's done. (gofundme.com)
  • Worries about having a relapse in later months or year(s), the late effects of chemotherapy, or some other types of treatment that could possibly be done outside the country. (gofundme.com)
  • In April 2012, MSF established a CTC to improve fetal outcomes in pregnant women by facilitating intensive follow- up for dehydration and rapid access to obstetric and neonatal services. (cdc.gov)
  • Dr Maria Sormani, PhD, Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy, addressed this problem in a lecture on immunomodulatory treatment of MS. The presentation was part of a Hot Topic series at the 29th Congress of the European Committee for the Treatment and Research in Multiple Sclerosis (ECTRIMS). (ajmc.com)
  • Research studies have shown that shared decision-making has led to better outcomes for people with conditions including diabetes, cardiovascular disease, and various cancers. (dana.org)
  • Research suggests that cannabis use affects negatively on onset and outcome of schizophrenia, but less is known about possible effects in mood disorders. (lww.com)
  • The research involved people who received care at 14 treatment centres across the US. (aidsmap.com)
  • Outcomes analysed in the research were overall survival, transplant failure, risk of infections and rebound in HIV viral load. (aidsmap.com)
  • Understanding health care outcomes research / edited by Robert L. Kane. (who.int)
  • This research finds conclusive evidence that methadone maintenance treatment (MMT) is more costeffective than center-based compulsory treatment (CCT) in reducing heroin use, blood-borne virus risk behaviors, drug-related illegal behaviors and monthly drug spending. (fhi360.org)
  • A group of equivalent children awaiting treatment and chosen from the same sample of children as the treatment participants served as a control group. (editlib.org)
  • Surgery represents the most important treatment modality in canine mammary tumors. (vin.com)
  • Magnetic resonance guided focused ultrasound (MRgFUS) is a non-invasive procedure that has recently been investigated as a new treatment modality for essential tremor (ET). (cns.org)
  • The Lung Cancer Program in Massachusetts General Hospital's Division of Thoracic Surgery provides comprehensive and innovative treatment for lung cancer. (massgeneral.org)
  • Treatment is often successful if the cancer has not spread. (medlineplus.gov)
  • In the fight against pancreatic cancer, clinical trials often provide the best treatment options. (pancan.org)
  • The Pancreatic Cancer Action Network strongly recommends clinical trials at diagnosis and during every treatment decision. (pancan.org)
  • Ensuring effective care transition communication: implementation of an electronic medical record-based tool for improved cancer treatment handoffs between clinic and infusion nurses. (ahrq.gov)
  • At the National Cancer Institute (NCI), Dr. McCaskill-Stevens explores how race impacts cancer outcomes, especially in African American women, who are 40% more likely to die from breast cancer than white women. (medlineplus.gov)
  • More minorities are being represented in clinical trials of breast cancer treatments. (medlineplus.gov)
  • The treatment of degenerative lumbar disorders. (medscape.com)
  • Although biliary tract cancers (BTC) are common in older age-groups, treatment approaches and outcomes are understudied in this population. (oncotarget.com)
  • Treatment, if even possible will be often complex, time consuming and expensive requiring multidisciplinary approaches. (bvsalud.org)
  • Over 12 months of treatment, cannabis users exhibited less compliance and higher levels of overall illness severity, mania, and psychosis compared with nonusers. (lww.com)
  • however the effect of this illness on the outcomes for conventional ED treatments has not been previously investigated. (biomedcentral.com)
  • Clinical epidemiology : the study of the outcome of illness / Noel S. Weiss. (who.int)
  • Does Dietary Folate Intake Modify Treatment-related Toxicity or Disease Outcome Among Children with Acute Lymphoblastic Leukemia? (aicr.org)
  • We proposed this study aiming to investigate the application of PK- guided 5-FU and Docetaxel dosing and to evaluate its effect on treatment outcome and toxicity profile. (scirp.org)
  • Psychosocial treatment, also known as behavioral health treatment, is recommended in conjunction with all drug therapies for OUD. (pewtrusts.org)
  • Call 310-582-6350 to learn more about vasculitis treatment at UCLA Health. (uclahealth.org)
  • The UCLA Health Vasculitis Program is the first comprehensive, multispecialty program dedicated to vasculitis treatment in Southern California. (uclahealth.org)
  • Purpose: The impact of a newly designed computer-assisted treatment ('C-AT') program, 'My Sentence Builder', for the remediation of expressive-grammar deficits in children with specific language impairment (SLI) was explored. (editlib.org)
  • So they had to introduce themselves and then explain what the study was about with the treatment, how the treatment works. (medicaleconomics.com)
  • Study duration is expected to be approximately 10 years, including a 28-day screening period, followed by an up to 36-month treatment period, and a follow-up period of approximately 7 years. (clinicaltrials.gov)
  • The purpose of this preclinical study was to understand what kind of pretreatment parameters, or 3-week on-treatment parameters, were associated with outcomes after that single dose of PD-1 antibody. (medscape.com)
  • Comparative study of PILF and TLIF treatment in adult degenerative spondylolisthesis. (medscape.com)
  • Treatment outcome for the teeth with a cemental tear was assessed in a multicenter cemental tear study project. (bvsalud.org)
  • In this study, we were comparing new treatments (auto-adaptive directional hearing aids) to how normal- hearing individuals function (gold standard) in the same listening environment. (cdc.gov)
  • The current standard for assessing treatment results in MS is the randomized clinical trial (RCT), which typically lasts 2 to 3 years. (ajmc.com)
  • While observational studies are limited by biases, according to Sormani, long-term follow-up results are limited by an unclear distinction between early and delayed treatment start, and drop-out rates. (ajmc.com)
  • Our results demonstrate the effectiveness of percutaneous needle aspiration and it should be considered a first-line treatment in the management of liver abscess, irrespective of their number and sizes. (annals.edu.sg)
  • But you can also share and visualise your treatment results with other members of the SCHWIND user family sharing WiseNET via the SCHWIND Cloud Community. (eye-tech-solutions.com)
  • Interestingly, clinicians would like to know when treatment results aren't different from each other, but non-significant findings are often difficult to publish and are rarely in the interest of manufacturers to present. (cdc.gov)