Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Elements of limited time intervals, contributing to particular results or situations.
A treatment method in which patients are under direct observation when they take their medication or receive their treatment. This method is designed to reduce the risk of treatment interruption and to ensure patient compliance.
A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
Evaluation procedures that focus on both the outcome or status (OUTCOMES ASSESSMENT) of the patient at the end of an episode of care - presence of symptoms, level of activity, and mortality; and the process (ASSESSMENT, PROCESS) - what is done for the patient diagnostically and therapeutically.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The return of a sign, symptom, or disease after a remission.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
MYCOBACTERIUM infections of the lung.
Voluntary cooperation of the patient in following a prescribed regimen.
Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Disorders related or resulting from abuse or mis-use of opioids.
Disorders related to substance abuse.
A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication.
Health facilities providing therapy and/or rehabilitation for substance-dependent individuals. Methadone distribution centers are included.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
An infant during the first month after birth.
Therapy with two or more separate preparations given for a combined effect.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Hospitals which provide care to patients with long-term illnesses.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.
Habitual moderation in the indulgence of a natural appetite, especially but not exclusively the consumption of alcohol.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.
Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Discontinuance of care received by patient(s) due to reasons other than full recovery from the disease.
A method for extinguishing anxiety by a saturation exposure to the feared stimulus situation or its substitute.
Disorders related or resulting from use of cocaine.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
A specialized residential treatment program for behavior disorders including substance abuse. It may include therapeutically planned group living and learning situations including teaching of adaptive skills to help patient functioning in the community. (From Kahn, A. P. and Fawcett, J. Encyclopedia of Mental Health, 1993, p320.)
The therapy of the same disease in a patient, with the same agent or procedure repeated after initial treatment, or with an additional or alternate measure or follow-up. It does not include therapy which requires more than one administration of a therapeutic agent or regimen. Retreatment is often used with reference to a different modality when the original one was inadequate, harmful, or unsuccessful.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Agents used to treat RETROVIRIDAE INFECTIONS.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Simultaneous infection of a host organism by two or more pathogens. In virology, coinfection commonly refers to simultaneous infection of a single cell by two or more different viruses.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
The application of modern theories of learning and conditioning in the treatment of behavior disorders.
Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Medical treatment for opioid dependence using a substitute opiate such as METHADONE or BUPRENORPHINE.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
The concurrent or retrospective review by practicing physicians or other health professionals of the quality and efficiency of patient care practices or services ordered or performed by other physicians or other health professionals (From The Facts On File Dictionary of Health Care Management, 1988).
A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).
Agents inhibiting the effect of narcotics on the central nervous system.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Disease having a short and relatively severe course.
The period of confinement of a patient to a hospital or other health facility.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
A scale that assesses the outcome of serious craniocerebral injuries, based on the level of regained social functioning.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Those factors which cause an organism to behave or act in either a goal-seeking or satisfying manner. They may be influenced by physiological drives or by external stimuli.
The phase of orthodontics concerned with the correction of malocclusion with proper appliances and prevention of its sequelae (Jablonski's Illus. Dictionary of Dentistry).
An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
A behavior therapy technique in which deep muscle relaxation is used to inhibit the effects of graded anxiety-evoking stimuli.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Health care services provided to patients on an ambulatory basis, rather than by admission to a hospital or other health care facility. The services may be a part of a hospital, augmenting its inpatient services, or may be provided at a free-standing facility.
The co-existence of a substance abuse disorder with a psychiatric disorder. The diagnostic principle is based on the fact that it has been found often that chemically dependent patients also have psychiatric problems of various degrees of severity.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
The ratio of the number of conceptions (CONCEPTION) including LIVE BIRTH; STILLBIRTH; and fetal losses, to the mean number of females of reproductive age in a population during a set time period.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Substances that reduce the growth or reproduction of BACTERIA.
A pyrazine that is used therapeutically as an antitubercular agent.
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing pain.
Tumors or cancer of the NOSE.
A dental specialty concerned with the prevention and correction of dental and oral anomalies (malocclusion).
The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
Substances interfering with the metabolism of ethyl alcohol, causing unpleasant side effects thought to discourage the drinking of alcoholic beverages. Alcohol deterrents are used in the treatment of alcoholism.
The confinement of a patient in a hospital.
Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.
Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.
A selective serotonin uptake inhibitor that is used in the treatment of depression.
A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
Drug regimens, for patients with HIV INFECTIONS, that aggressively suppress HIV replication. The regimens usually involve administration of three or more different drugs including a protease inhibitor.
Strong dependence, both physiological and emotional, upon heroin.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Social and economic factors that characterize the individual or group within the social structure.
Interactions between health personnel and patients.
Statistical interpretation and description of a population with reference to distribution, composition, or structure.
Persistent and disabling ANXIETY.
A republic in eastern Africa, south of SUDAN and west of KENYA. Its capital is Kampala.
Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
Substances obtained from various species of microorganisms that are, alone or in combination with other agents, of use in treating various forms of tuberculosis; most of these agents are merely bacteriostatic, induce resistance in the organisms, and may be toxic.
A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
The branch of philosophy dealing with the nature of the beautiful. It includes beauty, esthetic experience, esthetic judgment, esthetic aspects of medicine, etc.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
A republic in southern Africa, the southernmost part of Africa. It has three capitals: Pretoria (administrative), Cape Town (legislative), and Bloemfontein (judicial). Officially the Republic of South Africa since 1960, it was called the Union of South Africa 1910-1960.
Assessment of psychological variables by the application of mathematical procedures.
A form of group psychotherapy. It involves treatment of more than one member of the family simultaneously in the same session.
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Tumors or cancer of the human BREAST.
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.
Treatment that combines chemotherapy with radiotherapy.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Compounds that specifically inhibit the reuptake of serotonin in the brain.
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Tumors or cancer of the NASOPHARYNX.
Procedures used for the targeted destruction of the mucous membrane lining of the uterine cavity.
Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
A range of values for a variable of interest, e.g., a rate, constructed so that this range has a specified probability of including the true value of the variable.
Tumors or cancer of the LUNG.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.
A republic in southern Africa east of ZAMBIA and MOZAMBIQUE. Its capital is Lilongwe. It was formerly called Nyasaland.
Presentation devices used for patient education and technique training in dentistry.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
The excessive use of marijuana with associated psychological symptoms and impairment in social or occupational functioning.
A second-line antitubercular agent that inhibits mycolic acid synthesis.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Diminished or absent ability of a female to achieve conception.
An interval of care by a health care facility or provider for a specific medical problem or condition. It may be continuous or it may consist of a series of intervals marked by one or more brief separations from care, and can also identify the sequence of care (e.g., emergency, inpatient, outpatient), thus serving as one measure of health care provided.
Conscious or unconscious emotional reaction of the therapist to the patient which may interfere with treatment. (APA, Thesaurus of Psychological Index Terms, 8th ed.)
The performance of the basic activities of self care, such as dressing, ambulation, or eating.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.
Persons who receive ambulatory care at an outpatient department or clinic without room and board being provided.
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Moving a retruded mandible forward to a normal position. It is commonly performed for malocclusion and retrognathia. (From Jablonski's Dictionary of Dentistry, 1992)
A state of harmony between internal needs and external demands and the processes used in achieving this condition. (From APA Thesaurus of Psychological Index Terms, 8th ed)

Perioperative growth hormone treatment and functional outcome after major abdominal surgery: a randomized, double-blind, controlled study. (1/106051)

OBJECTIVE: To evaluate short- and long-term effects of perioperative human growth hormone (hGH) treatment on physical performance and fatigue in younger patients undergoing a major abdominal operation in a normal postoperative regimen with oral nutrition. SUMMARY BACKGROUND DATA: Muscle wasting and functional impairment follow major abdominal surgery. METHODS: Twenty-four patients with ulcerative colitis undergoing ileoanal J-pouch surgery were randomized to hGH (12 IU/day) or placebo treatment from 2 days before to 7 days after surgery. Measurements were performed 2 days before and 10, 30, and 90 days after surgery. RESULTS: The total muscle strength of four limb muscle groups was reduced by 7.6% in the hGH group and by 17.1% in the placebo group at postoperative day 10 compared with baseline values. There was also a significant difference between treatment groups in total muscle strength at day 30, and at the 90-day follow-up total muscle strength was equal to baseline values in the hGH group, but still significantly 5.9% below in the placebo group. The work capacity decreased by approximately 20% at day 10 after surgery, with no significant difference between treatment groups. Both groups were equally fatigued at day 10 after surgery, but at day 30 and 90 the hGH patients were less fatigued than the placebo patients. During the treatment period, patients receiving hGH had reduced loss of limb lean tissue mass, and 3 months after surgery the hGH patients had regained more lean tissue mass than placebo patients. CONCLUSIONS: Perioperative hGH treatment of younger patients undergoing major abdominal surgery preserved limb lean tissue mass, increased postoperative muscular strength, and reduced long-term postoperative fatigue.  (+info)

Single blind, randomised controlled trial of pelvic floor exercises, electrical stimulation, vaginal cones, and no treatment in management of genuine stress incontinence in women. (2/106051)

OBJECTIVE: To compare the effect of pelvic floor exercises, electrical stimulation, vaginal cones, and no treatment for genuine stress incontinence. DESIGN: Stratified, single blind, randomised controlled trial. SETTING: Multicentre. PARTICIPANTS: 107 women with clinically and urodynamically proved genuine stress incontinence. Mean (range) age was 49.5 (24-70) years, and mean (range) duration of symptoms 10.8 (1-45) years. INTERVENTIONS: Pelvic floor exercise (n=25) comprised 8-12 contractions 3 times a day and exercise in groups with skilled physical therapists once a week. The electrical stimulation group (n=25) used vaginal intermittent stimulation with the MS 106 Twin at 50 Hz 30 minutes a day. The vaginal cones group (n=27) used cones for 20 minutes a day. The untreated control group (n=30) was offered the use of a continence guard. Muscle strength was measured by vaginal squeeze pressure once a month. MAIN OUTCOME MEASURES: Pad test with standardised bladder volume, and self report of severity. RESULTS: Improvement in muscle strength was significantly greater (P=0.03) after pelvic floor exercises (11.0 cm H2O (95% confidence interval 7.7 to 14.3) before v 19.2 cm H2O (15.3 to 23.1) after) than either electrical stimulation (14.8 cm H2O (10. 9 to 18.7) v 18.6 cm H2O (13.3 to 23.9)) or vaginal cones (11.8 cm H2O (8.5 to 15.1) v 15.4 cm H2O (11.1 to 19.7)). Reduction in leakage on pad test was greater in the exercise group (-30.2 g; -43. 3 to 16.9) than in the electrical stimulation group (-7.4 g; -20.9 to 6.1) and the vaginal cones group (-14.7 g; -27.6 to -1.8). On completion of the trial one participant in the control group, 14 in the pelvic floor exercise group, three in the electrical stimulation group, and two in the vaginal cones group no longer considered themselves as having a problem. CONCLUSION: Training of the pelvic floor muscles is superior to electrical stimulation and vaginal cones in the treatment of genuine stress incontinence.  (+info)

Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine. The European Study Group. (3/106051)

OBJECTIVE: To assess intermittent treatment over 12 months in patients with symptomatic gastro-oesophageal reflux disease. DESIGN: Randomised, multicentre, double blind, controlled study. Patients with heartburn and normal endoscopy results or mild erosive changes received omeprazole 10 mg or 20 mg daily or ranitidine 150 mg twice daily for 2 weeks. Patients remaining symptomatic had omeprazole 10 mg or ranitidine dose doubled for another 2 weeks while omeprazole 20 mg was continued for 2 weeks. Patients who were symptomatic or mildly symptomatic were followed up for 12 months. Recurrences of moderate or severe heartburn during follow up were treated with the dose which was successful for initial symptom control. SETTING: Hospitals and primary care practices between 1994 and 1996. SUBJECTS: 677 patients with gastro-oesophageal reflux disease. MAIN OUTCOME MEASURES: Total time off active treatment, time to failure of intermittent treatment, and outcomes ranked from best to worst. RESULTS: 704 patients were randomised, 677 were eligible for analyses; 318 reached the end of the study with intermittent treatment without recourse to maintenance antisecretory drugs. The median number of days off active treatment during follow up was 142 for the entire study (281 for the 526 patients who reached a treatment related end point). Thus, about half the patients did not require treatment for at least 6 months, and this was similar in all three treatment groups. According to outcome, 378 (72%) patients were in the best outcome ranks (no relapse or one (or more) relapse but in remission until 12 months); 630 (93%) had three or fewer relapses in the intermittent treatment phase. Omeprazole 20 mg provided faster relief of heartburn. The results were similar in patients with erosive and non-erosive disease. CONCLUSIONS: Intermittent treatment is effective in managing symptoms of heartburn in half of patients with uncomplicated gastro-oesophageal reflux disease. It is simple and applicable in general practice, where most patients are seen.  (+info)

Optimal thrombolytic strategies for acute myocardial infarction--bolus administration. (4/106051)

Optimal strategies for thrombolysis in myocardial infarction (TIMI) are still being sought because the TIMI 3 flow rates achievable using standard regimens average approximately 60%. Double bolus administration of recombinant tissue plasminogen activator (tPA) is a novel approach with potential for earlier patency combined with ease of administration. We reviewed total patency rates, TIMI 3 patency rates, mortality, stroke and intracranial haemorrhage rates in the major trials of accelerated infusion tPA/bolus tPA/reteplase in acute myocardial infarction. A direct comparison was performed with results of two recent trials of double bolus (two 50 mg boli, 30 min apart) vs. accelerated infusion tPA: the Double Bolus Lytic Efficacy Trial (DBLE), an angiographic study, and the COBALT Trial, a mortality study. The DBLE trial showed equivalent patency rates for accelerated infusion and double bolus administration of tPA. Reviewing other angiographic trials, total patency and TIMI 3 patency rates achievable with double bolus tPA were comparable to those with accelerated infusion tPA or bolus reteplase administration. The COBALT study demonstrated a 30-day mortality of 7.53% in patients treated with accelerated infusion tPA compared with 7.98% for double bolus tPA treated patients. The small excess in mortality with double bolus treatment was confined to the elderly; in those < or = 75 years, mortality rates were 5.6% and 5.7%, for double bolus and accelerated infusion, respectively, and rates for death or non-fatal stroke were 6.35% and 6.3%, respectively. Comparison with other trials demonstrated mortality, stroke and intracranial haemorrhage rates with double bolus treatment similar to those associated with either accelerated infusion tPA or bolus reteplase treatment. Double bolus administration of tPA to patients with acute myocardial infarction is associated with total patency, TIMI 3 patency, mortality, stroke and intracranial haemorrhage rates similar to those associated with either accelerated infusion of tPA or bolus reteplase.  (+info)

Late referral of end-stage renal failure. (5/106051)

We studied all new patients accepted for renal replacement therapy (RRT) in one unit from 1/1/96 to 31/12/97 (n = 198), to establish time from nephrology referral to RRT, evidence of renal disease prior to referral and the adequacy of renal management prior to referral. Sixty four (32.3%, late referral group) required RRT within 12 weeks of referral. Fifty-nine (29.8%) had recognizable signs of chronic renal failure > 26 weeks prior to referral. Patients starting RRT soon after referral were hospitalized for significantly longer on starting RRT (RRT within 12 weeks of referral, median hospitalization 25.0 days (n = 64); RRT > 12 weeks after referral, median 9.7 days (n = 126), (p < 0.001)). Observed survival at 1 year was 68.3% overall, with 1-year survival of the late referral and early referral groups being 60.5% and 72.5%, respectively (p = NS). Hypertension was found in 159 patients (80.3%): 46 (28.9%) were started on antihypertensive medication following referral, while a further 28 (17.6%) were started on additional antihypertensives. Of the diabetic population (n = 78), only 26 (33.3%) were on an angiotensin-converting-enzyme inhibitor (ACEI) at referral. Many patients are referred late for dialysis despite early signs of renal failure, and the pre-referral management of many of the patients, as evidenced by the treatment of hypertension and use of ACEI in diabetics, is less than optimal.  (+info)

Tumour ablation and hepatic decompensation rates in multi-agent chemoembolization of hepatocellular carcinoma. (6/106051)

Thirty-seven cirrhotic patients with 62 hepatocellular carcinoma (HCC) foci--most Child-Pugh class B or C and/or with large, inoperable tumours--underwent 148 sessions of transcatheter arterial chemoembolization (TACE) using lipiodol, doxorubicin and cisplatin. Treatment efficacy was assessed by serial hepatic arteriography in 34/37 (91.9%) patients and abdominal CT scanning in 3/37 (8.1%) patients. Child-Pugh status was determined prior to each treatment session. Varying degrees of control of tumour neovascularity occurred for a median 390 days (range 90 to > 1680 days) in 33/34 (97.1%) patients in whom progress hepatic arteriography was performed. Ablation of tumour neovascularity occurred in 6/6 (100%), 4/12 (33.3%) and 6/16 (37.5%) patients with HCC diameters < 4 cm, 4-7 cm and > 8 cm, respectively (p < 0.02). Significantly more sessions were required for ablation of larger tumours (p < 0.05). Recurrent HCC was detected in 50% of patients after a median 240 days (range 60-1120 days). Deterioration in Child-Pugh status followed a session of TACE on 19/148 (12.8%) occasions but resulted in unscheduled hospitalization on only 4/148 (2.7%) occasions, the highest incidence (8.3%) in Child-Pugh C patients. Actuarial survival was 27/36 (75.0%) at 6 months, 17/34 (50.0%) at 12 months, 14/34 (41.2%) at 18 months, 9/31 (29.0%) at 24 months and 4/27 (14.8%) at 36 months. Multi-agent TACE with lipiodol, doxorubicin and cisplatin provides a useful anti-tumour effect, even in cirrhotic patients with large HCCs. The incidence of clinically significant deterioration in hepatic function due to ischaemia of non-tumorous liver is acceptably low, even in Child-Pugh C patients.  (+info)

Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, double-blind, placebo-controlled trial. (7/106051)

OBJECTIVE: To determine whether interferon-alpha (IFNalpha) reduces the severity of skin involvement in early (<3 years) diffuse scleroderma. METHODS: In a randomized, placebo-controlled, double-blind trial, 35 patients with early scleroderma received subcutaneous injections of either IFNalpha (13.5 x 10(6) units per week in divided doses) or indistinguishable placebo. Outcomes assessed were the modified Rodnan skin score, as determined by a single observer at baseline, 6 months, and 12 months, as well as data on renal, cardiac, and lung function. Pre- and posttreatment skin biopsy samples were analyzed and blood was obtained for assessment of procollagen peptide levels. RESULTS: There were 11 withdrawals from the IFNalpha group and 3 from the placebo group due to either toxicity, lack of efficacy, or death. In the intent-to-treat analysis, there was a greater improvement in the skin score in the placebo group between 0 and 12 months (mean change IFNalpha -4.7 versus placebo -7.5; P = 0.36). There was also a greater deterioration in lung function in patients receiving active therapy, as assessed by either the forced vital capacity (mean change IFNalpha -8.2 versus placebo +1.3; P = 0.01) or the diffusing capacity for carbon monoxide (mean change IFNalpha -9.3 versus placebo +4.7; P = 0.002). Skin biopsy showed no significant decrease in collagen synthesis in the IFNalpha group, and no significant differences in the levels of procollagen peptides were seen between the 2 groups. CONCLUSION: This study suggests that IFNalpha is of no value in the treatment of scleroderma, and that it may in fact be deleterious.  (+info)

Economic consequences of the progression of rheumatoid arthritis in Sweden. (8/106051)

OBJECTIVE: To develop a simulation model for analysis of the cost-effectiveness of treatments that affect the progression of rheumatoid arthritis (RA). METHODS: The Markov model was developed on the basis of a Swedish cohort of 116 patients with early RA who were followed up for 5 years. The majority of patients had American College of Rheumatology (ACR) functional class II disease, and Markov states indicating disease severity were defined based on Health Assessment Questionnaire (HAQ) scores. Costs were calculated from data on resource utilization and patients' work capacity. Utilities (preference weights for health states) were assessed using the EQ-5D (EuroQol) questionnaire. Hypothetical treatment interventions were simulated to illustrate the model. RESULTS: The cohort distribution among the 6 Markov states clearly showed the progression of the disease over 5 years of followup. Costs increased with increasing severity of the Markov states, and total costs over 5 years were higher for patients who were in more severe Markov states at diagnosis. Utilities correlated well with the Markov states, and the EQ-5D was able to discriminate between patients with different HAQ scores within ACR functional class II. CONCLUSION: The Markov model was able to assess disease progression and costs in RA. The model can therefore be a useful tool in calculating the cost-effectiveness of different interventions aimed at changing the progression of the disease.  (+info)

Looking for alternative treatment options for your older dog? Today we are looking at 6 alternative treatment options for senior dogs that you can consider.
Special diet:. Diet therapy is one of the important ADHD alternative treatment methods. Changes in the diet may help your child to deal with allergy symptoms or migraine headaches.. Biofeedback: This ADHD alternative treatment method helps your child to control their own responsibilities. This therapy involves a large commitment from your whole family.. This ADHD alternative treatment option helps children learn coping skills and that give them a sense of control and mastery. This therapy helps to reduce stress and anger that can accompany with ADHD.. Herbal medicine: Herbs act as ADHD alternative treatment method. You can find a number of all natural herbal treatments sold in the United States for the control of ADHD in children. Herbs can help to calm your child and they play important role in memory and thinking.. Make sure that herbs you are using are pure, safe, and nontoxic. Herbs can cause side effects and can interact with other medications.. Some of the herbs as ADHD alternative ...
As Table 3 shows, Case 1 presented with significant clinical improvement in rule following and working memory overtime, Case 2 presented with significant clinical improvement in cognitive flexibility, and rule following, while Case 3 presented with significant clinical improvement in cognitive flexibility, inhibition response and speed processing. As can be seen in Table 3, Case 1 presented a significant clinical improvement in social skills and behavior regulation, Case 2 presented with significant clinical improvement in emotional regulation and social skills, while Case 3 presented significant clinical deterioration in behavior regulation, emotional regulation and social skills over time.. DiscussionCognitive functions. Cognitive function domains included verbal comprehension, perceptual reasoning and IQ. Case 1 who had a cavernous angioma on the right frontal lobe showed an improvement followed by a decrease in verbal comprehension and perceptual reasoning, the results obtained in the last ...
To examine the association between the use and timing of IFN-α2b and clinical outcomes, we analyzed in a retrospective multicenter cohort study of 446 COVID-19 patients in Hubei, China. Regression models estimated that early administration (≤5 days after admission) of IFN-α2b was associated with reduced in-hospital mortality in comparison with no admission of IFN-α2b, whereas late administration of IFN-α2b was associated with increased mortality. Among survivors, early IFN-α2b was not associated with hospital discharge or computed tomography (CT) scan improvement, whereas late IFN-α2b was associated with delayed recovery. Additionally, early IFN-α2b and umifenovir alone or together were associated with reduced mortality and accelerated recovery in comparison with treatment with lopinavir/ritonavir (LPV/r) alone. Administration of IFN-α2b during the early stage of COVID-19 could induce favorable clinical responses.. ...
Medication is the most important treatment for bipolar disorders. I will outline the medication listed in the textbook and state their potential side effects and limitations in point form.Drug: LithiumLithium is the first choice of treatment for bipola...
We report a case of the 59-year-old men with portal hypertension and liver cirrhosis, who developed pulmonary arterial hypertension. The first line treatment with sildenafil 20 mg 3 times daily was introduced as part of a Polish National Treatment Program. At a 6-month follow-up we noticed a significant clinical improvement: the patients exercise capacity and echocardiographic parameters were substantially better. In addition, the B-type natriuretic propeptide significantly decreased. ...
Of 242 patients in CT group and 215 patients in no CT group, stage I to IV disease were 1.7%, 38.4%, 58.7%,1.2% and 5.6%, 46%, 47%, 1.4%, respectively. Pretreatment imaging found lymph node and/or distant metastases in 43.4% and upstaged in 27.6% of patients, according to the 7th AJCC system. Treatment modifications were elicited in 21.9% of patients; RT (13.2%), CMT (4.1%) and both (4.5%). At median follow-up time of 35 months, progression-free survival (PFS) and overall survival (OS) at 3 years in CT and no CT group were 70.1% vs 74.7% (p = 0.135) and 68.3% vs 76.4% (p = 0.016). Subgroup analysis by stage showed that patients with stage II disease in CT and no CT group had no significant difference in 3-year PFS and OS; 80.3% vs 83.3% (p = 0.673) and 81.3% vs 79.7% (p = 0.802), respectively. In stage III disease, patients in both groups had no significant difference in 3-year PFS, 64.1% in CT group and 68.4% in no CT group (p = 0.187). However, the 3-year OS was significantly worse in CT ...
TY - JOUR. T1 - Lymphadenectomy in Gleason 7 prostate cancer. T2 - Adherence to guidelines and effect on clinical outcomes. AU - Chandrasekar, Thenappan. AU - Goldberg, Hanan. AU - Klaassen, Zachary W A. AU - Sayyid, Rashid K.. AU - Hamilton, Robert J.. AU - Fleshner, Neil E.. AU - Kulkarni, Girish S.. PY - 2018/1. Y1 - 2018/1. N2 - Background To examine usage trends, guideline adherence, and survival data for patients undergoing lymphadenectomy (LND) at the time of radical prostatectomy (RP) for Gleason 7 prostate cancer (PCa). Methods The SEER database was queried for all patients with nonmetastatic biopsy Gleason 7 PCa from 2004 to 2013. Distribution and trends of LND were analyzed. The Memorial-Sloan Kettering Cancer Center nomogram was applied to stratify patients based on risk of nodal disease at time of RP (,5% risk or ≥5% risk). Analyses were performed to determine covariates associated with LND receipt at time of RP and cancer-specific mortality (CSM). Results A total of 78,641 ...
Women now have the choice to be given epidural anesthesia to help with pain during active labor. Local anesthetic will be administered into the epidural space of the spine which will be given continuously through a small catheter that is left taped to the womans back. It normally takes about five to thirty minutes for the effects to be felt, at which time the legs may begin to feel heavy and pain should subside. While it is generally safe for both the woman and baby when having an epidural, there are potential side effects they should be aware of.. Low blood pressure is one of the most common effects. Intravenous fluids will be administered at the same time in order to prevent this from occurring. Another common side effect is uncontrollable shivering. However, shivering is something that can happen to a woman during labor even without receiving an epidural, so getting an warm blanket is often enough to help control the shivers.. A loss of bladder control during labor can sometimes happen ...
BACKGROUND: Myocardial infarction (MI) in the absence of electrocardiographic ST-segment elevation or new bundle branch block is the cause of hospitalization for a large and steadily increasing proportion of patients with acute ischemic chest pain. Despite its prevalence, the common demographic features, current hospital-based management, and short-term clinical outcome among patients with non-ST-segment elevation MI remain poorly defined. METHODS: A total of 183 113 patients with non-ST-segment elevation MI were identified in the National Registry of Myocardial Infarction database. Using a validated model, 43 928 patients (24.0%) were retrospectively placed in major, 34 917 (19.1%) in intermediate, and 104 268 (56.9%) in minor severity clinical event categories that included hospital death, recurrent myocardial ischemia, and nonfatal recurrent MI. RESULTS: The administration of widely available and universally recommended pharmacologic therapies, including aspirin and beta-adrenergic blocking agents,
Myself and certain member(s) of the AM community wondered if there were any potential side effects to be concerned with (or to look out for) when
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Downloadable! Recently there has been a surge in econometric work focusing on estimating average treatment effects under various sets of assumptions. One strand of this literature has developed methods for estimating average treatment effects for a binary treatment under assumptions variously described as exogeneity, unconfoundedness, or selection on observables. The implication of these assumptions is that systematic (e.g., average or distributional) differences in outcomes between treated and control units with the same values for the covariates are attributable to the treatment. Recent analysis has considered estimation and inference for average treatment effects under weaker assumptions than typical of the earlier literature by avoiding distributional and functional form assumptions. Various methods of semiparametric estimation have been proposed, including estimating the unknown regression functions, matching, methods using the propensity score such as weighting and blocking, and combinations of
This is a randomized, double-blind, placebo-controlled, multicenter Phase III clinical trial to compare the efficacy and safety of Fruquintinib plus BSC versus placebo plus BSC in patients with metastatic colorectal cancer who have progressed after second-line or above standard chemotherapy. After checking eligibility criteria, subjects will be randomized into Fruquintinib plus BSC group (treatment group) or placebo plus BSC group (control group) in a ration of 2:1. Primary Efficacy Endpoint: Overall Survival (OS). Secondary Efficacy Endpoints: Progression free survival (PFS) (According to RECIST Version 1.1), Objective Response Rate (ORR), Disease Control Rate (DCR), . Safety and tolerance will be evaluated by incidence, severity and outcomes of AEs and categorized by severity in accordance with the NCI CTC AE Version 4.0 ...
This study compared two doses of pembrolizumab (MK-3475) versus docetaxel in participants with non-small cell lung cancer (NSCLC) who had experienced disease progression after platinum-containing systemic therapy. Participants were assigned randomly to receive either pembrolizumab 2 mg/kg once every three weeks (Q3W), pembrolizumab 10 mg/kg Q3W or docetaxel 75 mg/m^2 Q3W. This study used an adaptive trial design so that the total number of participants randomized depended upon demonstration of sufficient objective responses at an interim analysis.. Based on the positive outcome of the Overall Survival (OS) analysis, Protocol Amendment 12 (effective date: 09 Dec 2015) enabled eligible participants who were allocated to docetaxel and experienced disease progression, to be permitted to crossover to receive pembrolizumab 2 mg/kg Q3W as long as Inclusion/Exclusion criteria were met. These participants were participating in the Cross-Over Phase.. The primary study hypotheses are that pembolizumab ...
Duration of response was defined as progression-free survival in responders, i.e. as the time between the start of a complete response (CR) or partial response (PR) and the start of progressive disease (PD) or patient death from any cause, whichever occurred first. Participants who did not have progression or had not died were censored at the last known time the participant was progression free. Participants who had initiated other anticancer therapy prior to progression were censored at the time when new anticancer therapy was initiated. Complete response (CR) and partial response (PR) were defined in outcome #1. Progressive disease was defined as at least a 20% increase in the sum of the longest diameters of target lesions; or the appearance of one or more new lesions; or the unequivocal progression of a non-target lesion. Response was evaluated using Response Evaluation Criteria in Solid Tumors (RECIST ...
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The 12 groups, recognized by CDRRMO, are not affiliated with any barangay and do not receive any regular funding for their efforts and operations. Disaster responders of barangays are funded from their DRRM or five percent of the internal revenue allotment.. They are vital to the CDRRMO because they augment our resources and capacity during the implementation of some programs like the City Wide Simulation Exercises and especially during times of disasters, said Lyndon Leovic Ancajas, CDRRMO training officer.. Ancajas added that volunteer responders go through trainings and drills to improve their skills and capacity.. Carlo Danilo de Leon, president of the EAGLES Disaster Rescue Group, one of the largest volunteer responder groups in the city with over 600 members, welcomed the support given to them by the CDRRMO.. These equipment will enable us to respond better and keep us safe during operations, de Leon said.. Raniel Nocom, president of another volunteer responder group called Darcom, ...
Background. Minimally invasive surgery is increasingly applied because of the proven better outcome and benefits for the patient such as less pain, shorter hospital stay, and less injury. Examples of such minimally invasive procedure include Endovascular Aortic Repair (EVAR), endovascular coiling of intracranial aneurysms, and Transcatheter Aortic Valve Implantation (TAVI). These procedures have in common that a device is transported through the iliac and aortic artery after an incision in the groin to the problematic location in the body. Unfortunately, these percutaneous procedures are associated with vascular complications of the iliac artery. These vascular complications include bleeding, vascular rupture, aneurysm spurium, ateriorvenous fistula, dissection, and embolism. There are various clinical and technical procedural parameters associated with these vascular complications. Next to these parameters, the morphology and disease of the vasculature also influence the risk of vascular ...
What are the alternative options for kidney disease with 30% kidney function ? Are dialysis and renal transplant are the only options for them ?
A Randomized, Multicenter, Open Label Study of MM-302 plus Trastuzumab vs. Chemotherapy of Physicians Choice plus Trastuzumab in Anthracycline Naive Patients with Locally Advanced/Metastatic HER2-Positive Breast ...
This Phase IIIb study was conducted to evaluate the safety, efficacy and pharmacokinetics of darunavir/cobicistat 800/100 mg once daily in HIV-1-infected adults with no darunavir RAMs who also received two fully active N[t]RTIs. We showed that darunavir/cobicistat 800/150 mg once daily was well tolerated, and the pharmacokinetics, virologic and immunologic responses were consistent with previously published data for darunavir/ritonavir 800/100 mg once daily.. Through Week 24, the onset of any grade 3 or 4 AEs regardless of causality was low (6% in the overall population). Five out of 313 patients (2%), all of whom were treatment-naïve, experienced any study drug-related grade 3 AE through Weeks 24 and 48. No patients experienced grade 4 drug-related AEs. The most commonly reported AEs of all grades during the study, diarrhea, nausea, upper respiratory tract infection and headache, have all been reported previously for darunavir and cobicistat [5-8, 15, 16]. Renal laboratory assessments showed ...
DALLAS and TOKYO, Nov. 19, 2013- Daiichi Sankyos Once-Daily Edoxaban Meets Primary Efficacy Endpoint for Stroke Prevention and Superiority for the Principal Safety Endpoint Compared to Warfarin for Patients with Atrial Fibrillation in a Phase 3 Clinical Trial.
Question - Took all the possible treatment for sinus. Should i go for sinus surgery? . Ask a Doctor about diagnosis, treatment and medication for Allergic rhinitis, Ask an ENT Specialist
The incidence statistics of type 2 diabetes mellitus can only be reduced if individualized comprehensive treatment is offered to each patient, but without just leaving his illness, said Felix Scott, general manager of Sanofi Mexico.. In the framework of the International Forum of Leaders in Diabetes, the director said that people with this condition should not be considered mere figures, because each of them has its own reality.. He pointed out that pharmaceutical companies need to develop innovative medicines every day to improve and facilitate therapies, as well as to guide the physician with new tools and training in digital technologies to better monitor their patients.. Although the person with diabetes, he said, should be seen as a person who is the center of all efforts, understands his needs and his individual and family environment, because there are sufficient reasons for not adhering to the treatment.. Results will not be achieved at the statistical level, if we do not achieve ...
Generally, Diabetes easily causes Kidney Failure if patients do not take timely treatments. Well then, what is the comprehensive treatment for stage 4 kidney failure caused by diabetes?
Effectiveness at end of January 2013 was estimated to be 92%.. Coverage at end of January was estimated (using SQUEAC) to be 63%.. Impact can be estimated as:. Impact = Effectiveness x Coverage = 92% x 63% = 58%. Data courtesy of ACF (Pakistan). Coverage also depends indirectly on:. Thorough case-finding and early treatment seeking: This ensures that the majority of admissions are uncomplicated incident cases, which leads to good outcomes (Figure 1). Late admission is associated with the need for inpatient care, longer treatment, defaulting, and poor treatment outcomes (e.g. nonresponse after long stays in programme or death). These can lead to poor opinions of the programme circulating in the host population, which may lead to more late presentations and admissions and a cycle of negative feedback may develop (Figure 2). A high level of compliance by both the beneficiary and the provider: This ensures that the beneficiary receives a treatment of proven efficacy leading to good outcomes and good ...
Cancer 101 is a source for all the information related to cancer. Know about the common types of cancer, diagnosis, possible treatments and prevention tips.
Question - Pain in back gums, treated with salt water. Gums swollen, throbbing, itchy. Possible treatment? . Ask a Doctor about diagnosis, treatment and medication for Back pain, Ask a Dentist
Comprehensive treatment is undertaken for the majority of patients during the early teens. Treatment aims to create a beautiful, balanced and functional
Contemporary Management of HIV: Modifying Antiretroviral Therapy in Virologically Suppressed Patients and Those with Treatment ...
therapy. Treatment was continued until disease progression, discontinuation due to adverse events, or withdrawal of consent. Randomization was stratified according to PSA doubling time (≤ 6 months or , 6 months) and use of osteoclast-targeted therapy at randomization. The primary endpoint was metastasis-free survival in the intention-to-treat population, with the presence of metastasis identified by independent central review of radiographic imaging every 16 weeks.. For the darolutamide vs placebo groups, the median age was 74 years in both, most patients were from European countries, PSA doubling time was up to 6 months in 70% vs 67%, the Eastern Cooperative Oncology Group performance status was 0 or 1 in 100% in both, 97% vs 94% were not using a bone-sparing agent at baseline, and 76% of both groups had received at least 2 previous hormonal therapies.. Metastasis-Free Survival. On independent central review, metastasis was found at baseline in 5.2% of the darolutamide group and 7.0% of the ...
TY - JOUR. T1 - A case of reductions in bone and brain metastatic foci and remarkable improvements in general condition by gefitinib administrations in a patient with non-small cell lung carcinoma of progressive stage. AU - Hirose, Masahiro. AU - Tachikawa, Soichi. AU - Horiguchi, Takahiko. AU - Kondo, Reiko. AU - Shiga, Mamoru. AU - Sasaki, Yasushi. AU - Ito, Tomohiro. AU - Fukumoto, Koji. AU - Torigoe, Hiroshi. AU - Kobayashi, Kashin. AU - Hayashi, Nobuyuki. AU - Watanabe, Yasushi. AU - Oohira, Daisuke. PY - 2005/4/7. Y1 - 2005/4/7. N2 - A 60-year-old male patient, who presented at our hospital mainly complaining of pain in the shoulders and back, was diagnosed with stage IV primary B4 pulmonary adenocarcinoma (T3N0M1 with bone and brain metastases) based on a transbronchial lung biopsy (TBLB). Although chemotherapy was conducted after radio-surgical treatment of the brain metastatic focus with the γ-knife, his joint pain and general condition were exacerbated, in addition to the occurrence ...
The purpose of the study is to compare safety and efficacy of a single dose of empegfilgrastimt a dose of 3 or 6 mg versus daily administration of filgrastim at
Purpose: This multicenter, open-label, phase II study evaluated the safety and clinical activity of axitinib, a potent and selective second-generation inhibitor of vascular endothelial growth factor receptors (VEGFR)-1, 2, and 3, in patients with metastatic melanoma.. Experimental Design: Thirty-two patients with a maximum of one prior systemic therapy received axitinib at a starting dose of 5 mg twice daily. The primary endpoint was objective response rate.. Results: Objective response rate was 18.8% [95% confidence interval (CI), 7.2-36.4], comprising one complete and five partial responses with a median response duration of 5.9 months (95% CI, 5.0-17.0). Stable disease at 16 weeks was noted in six patients (18.8%), with an overall clinical benefit rate of 37.5%. Six-month progression-free survival rate was 33.9%, 1-year overall survival rate was 28.1%, and median overall survival was 6.6 months (95% CI, 5.2-9.0). The most frequently (,15%) reported nonhematologic, treatment-related adverse ...
A national, multi-center, open-label, phase IIIb trial to determine the efficacy and safety of treatment with ribociclib (LEE011) plus letrozole in women and
Randomised, double-masked, sham-controlled Phase 3b/4 study. All patients received 3 monthly IVT-AFL 2 mg injections. At Week 12, patients were randomised 1:1 into IVT-AFL plus sham PDT (IVT-AFL monotherapy) or IVT-AFL plus active PDT arms. Patients in both arms who did not qualify for rescue treatment received IVT-AFL 2 mg every 8 weeks (2q8); patients who qualified for rescue treatment received IVT-AFL 2q4 plus active or sham PDT, according to the randomisation arm, until visual and anatomical outcomes allowed for extension of the treatment interval. The primary efficacy endpoint was the mean change in BCVA in the study eye from baseline to Week 52. The secondary efficacy endpoint was the proportion of patients avoiding a moderate vision loss (≥15 letters) from baseline to Week 52. Exploratory endpoints included but were not limited to: (1) change in central subfield thickness ([CST] thickness of the central 1 mm of retina) over time; (2) proportion of patients with active polyps; (3) ...
A clinical trial of the Guardian implantable heart attack monitor made by Angel Medical Systems failed to meet its efficacy endpoint, but suggested that the device could be used to help detect silent heart attacks.. Wilmington, Del.-based AngelMed won FDA clearance a year ago for the Guardian device for patients with prior acute coronary syndrome events including myocardial infarctions or unstable angina at high risk for further ACS events. Its 907-patient Alerts study randomized patients implanted with Guardian to either six months with the alert function active for the treatment group or six months without activation for the control arm; both groups had the alert function activated after the six-month randomized stage.. The primary efficacy endpoint, a confirmed occlusive event within 7 days, was not significantly reduced for the treatment arm at 3.8%, compared with 4.9% for the control arm. The primary safety endpoint was met a 96.7% rate of freedom from device-related complications, ...
This pragmatic cluster RCT implemented in CHSs in urban China found no differential treatment effect in the primary outcome measure, HbA1c, with intervention and control groups both improving significantly. However, significant treatment effects favouring the intervention group were evident in psychological distress, systolic BP, waist circumference in men and SDSCA-Specific Diet. Two of these outcomes (psychological distress and systolic BP) were robust outcomes consistent with significant treatment effects, as supported in sensitivity analyses.. In addition to being statistically significant, the greater psychological distress observed in the control group compared with that in the intervention group is of clinical significance. The shift in the mean score for the control group at baseline from 14.97±6.24 to 17.45±8.12 at 12 months translates clinically to a shift in the mean from low risk of psychological distress (scores 10-15) to moderate risk of psychological distress (16-21).27 This ...
Background: Superiority clinical trials hold promises of impactful interventions for the future of evidence-based medicine but require extensive resources and may place study patients at risk. Advances made through cardiovascular (CV) trials in past decades have drastically improved patient outcomes, but little is known about the modern landscape of CV superiority trials and how it has evolved over time.. Methods: We performed a comprehensive search in PubMed using keywords and MeSH terms to identify all superiority CV trials with a primary clinical endpoint from January 1, 2006 to December 31, 2011 in the New England Journal of Medicine (NEJM), JAMA, and the Lancet. We used chi-square and Cochran-Armitage Trend tests to assess for statistical significance.. Results: We identified 188 trials (108 drug trials, 20 device trials and 60 others). Overall, 69 trials (36.7%) had positive results, demonstrating superiority of the new intervention for the primary endpoint, while 119 trials (63.3%) showed ...
Multiple treatment comparison (MTC) meta-analysis uses both direct (head-to-head) randomized clinical trial (RCT) evidence as well as indirect evidence from RCTs to compare the relative effectiveness of all included interventions. The methodological quality of MTCs may be difficult for clinicians to …
Lung Institute White Paper Reveals Evidence of Pulmonary Function Improvement from Stem Cell Therapy 21 Jan 2016 by Maren Auxier Lung Institute White Paper A new white paper released by the Lung Institute shows an increase of 10 percent or more in pulmonary function for 48 percent of patients tested after receiving stem cell therapy for COPD, with an overall average increase of 16 percent. TAMPA, Fla. January 26, 2016: Lung Institute doctor Jack Coleman, Jr., M.D. recently
ONGLYZA® (saxagliptin) achieves primary safety endpoint, demonstrating no increased risk for cardiovascular death, heart attack or stroke in SAVOR cardiovascular outcomes trial
TY - JOUR. T1 - Posttreatment infarct volumes when compared with 24-hour and 90-day clinical outcomes. T2 - Insights from the REVASCAT randomized controlled trial. AU - Al-Ajlan, F. S.. AU - Sultan, A. S.Al. AU - Minhas, P.. AU - Assis, Z.. AU - Miquel, M. A.De. AU - Millan, M.. AU - San Roman, L.. AU - Tomassello, A.. AU - Demchuk, A. M.. AU - Jovin, T. G.. AU - Cuadras, P.. AU - Davalos, A.. AU - Goyal, M.. AU - Menon, B. K.. N1 - Funding Information: REVASCAT was funded by a local independent Catalan institution (Fundació Ictus Malaltia Vascular) through an unrestricted grant from the manufacturer of the device (Covidien). This project has been partially supported by a grant from the Spanish Ministry of Health cofinanced by FEDER (Instituto de Salud Carlos III, RETICS-INVICTUS PLUS, RD 16/0019).. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background and Purpose: Endovascular therapy has become the standard of care for patients with disabling anterior circulation ischemic stroke due to proximal ...
TY - JOUR. T1 - Network meta-analysis of antiplatelet therapy following coronary artery bypass grafting (CABG). T2 - none versus one versus two antiplatelet agents. AU - Chakos, Adam. AU - Jbara, Dean. AU - Singh, Kamal. AU - Yan, Tristan D.. AU - Tian, David H.. PY - 2018/9/1. Y1 - 2018/9/1. N2 - Background: Numerous agents have been trialed following coronary artery bypass grafting (CABG) to maintain long-term graft patency. While clear evidence exists for the use of aspirin in maintaining graft patency, the role of dual-antiplatelet therapy in CABG patients is not as well established. This network meta-analysis aimed to compare the short-term post-CABG graft patency outcomes for patients with none, one or two antiplatelet agents. Methods: Electronic databases were queried for randomized controlled trials comparing CABG graft patency rates at three months and beyond using various antiplatelet agents or placebo. Drug and graft patency data were compared using a mixed treatment comparison under ...
Impact of perioperative myocardial infarction on angiographic and clinical outcomes following coronary artery bypass grafting (from PRoject of Ex-vivo Vein graft ENgineering via Transfection [PREVENT] IV).
TY - JOUR. T1 - Long-term outcome following programmed electrical stimulation in patients with high-grade ventricular ectopy. AU - Kharsa, M. H.. AU - Gold, R. L.. AU - Moore, H.. AU - Yazaki, Y.. AU - Haffajee, C. I.. AU - Alpert, Joseph S. PY - 1988. Y1 - 1988. N2 - To determine if programmed electrical stimulation (PES) could be utilized to identify patients with high-grade ventricular ectopy at low- or high-risk for sudden cardiac death, we performed PES in 40 patients with high-grade ventricular ectopy refractory to conventional antiarrhythmic agents. Twenty-one patients had a previous myocardial infarction, five had cardiomyopathy, six had hypertension, three had valvular heart disease and five had no known structural heart disease. The mean age was 60 years (range, 18 to 76). During programmed ventricular stimulation, eight patients had inducible sustained (more than 30 seconds) monomorphic ventricular tachycardia (Group I) but in 32 patients sustained ventricular tachycardia was not ...
TY - JOUR. T1 - Factors influencing outcome in patients undergoing portal vein resection for adenocarcinoma of the pancreas. AU - Banz, V. M.. AU - Croagh, D.. AU - Coldham, C.. AU - Tanière, P.. AU - Buckels, J.. AU - Isaac, J.. AU - Mayer, Diane. AU - Muiesan, P.. AU - Bramhall, S.. AU - Mirza, D. F.. PY - 2012/1. Y1 - 2012/1. N2 - Background: Survival rates after surgery and adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PDA) remain low. Selected patients with portal/superior mesenteric vein (PV) involvement undergo PV resection at pancreaticoduodenectomy (PD). This study analyses outcomes for PD with/without PV resection in patients with PDA. Methods: A retrospective analysis of prospectively collected data on patients requiring PD for histologically proven adenocarcinoma between 1/1997 and 9/2009 identified 326 patients with PDA, with 51 requiring PD with PV resection. Patients were analyzed in two groups: PD + PV resection vs. PD alone. Multivariate analysis was used to ...
In this prospective study of a large cohort of patients with primary THA, we found that after adjusting for important predictors, patients with OA had significantly better functional outcomes compared to those with RA/inflammatory arthritis at two-year follow-up. Results were notable for overall ADL limitation and key ADLs. Pain outcomes were not significantly different for OA versus RA. We also found that patients with AVN experienced better ADL outcome at two years compared to RA patients. In contrast, patients with AVN reported worse pain outcomes at five years compared to those with RA. Several findings in our study are of interest and merit further discussion.. One of the main findings of our study was that patients with OA had significantly better functional outcomes compared to those with RA at the two-year follow-up, as indicated by lower odds of overall moderate-severe ADL limitation. These findings were confirmed for patients younger and older than 65 years. To our knowledge, this is ...
TY - JOUR. T1 - Erratum to Predictive value of white blood cell subtypes for long-term outcome following myocardial infarctions [Atherosclerosis 196 (2008) 405-412]. AU - Dragu, Robert. AU - Khoury, Shafik. AU - Zuckerman, Robert. AU - Suleiman, Mahmoud. AU - Mutlak, Diab. AU - Agmon, Yoram. AU - Kapeliovich, Michael. AU - Beyar, Rafael. AU - Markiewicz, Walter. AU - Hammerman, Haim. AU - Aronson, Doron. PY - 2012/4. Y1 - 2012/4. UR - http://www.scopus.com/inward/record.url?scp=84858701209&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84858701209&partnerID=8YFLogxK. U2 - 10.1016/j.atherosclerosis.2006.11.045. DO - 10.1016/j.atherosclerosis.2006.11.045. M3 - Article. AN - SCOPUS:84858701209. VL - 221. SP - 605. JO - Atherosclerosis. JF - Atherosclerosis. SN - 0021-9150. IS - 2. ER - ...
Neoadjuvant breast cancer trials are important for speeding up the introduction of new treatments for patients with early breast cancer and for the highly productive translational research which they facilitate. Meta-analysis of trial data shows clear correlation between pathological response at surgery after neoadjuvant chemotherapy and longer-term outcomes at an individual patient level. However, this does not appear to be present on individual trial level analysis, when correlating improved outcome for the investigational arm for the primary endpoint (pathological response) with longer-term outcomes. The correlation between pathological response and longer-term outcomes in trials is dependent on many factors. These include definitions of pathological response, both complete and partial; assessment methods for pathological response at surgery; subtype and prognosis of breast cancer at diagnosis; number of patients recruited; adjuvant treatments; the mechanism of action of the investigational drug; the
Dr. David Parish, co-creator and lead instructor for MOTUS Therapeutic Methods, goes on to say, I am a firm believer in the Olympic ideal of Citius, Altius, Fortius; Faster, Higher, Stronger, and I look to bring those ideals to those I treat and teach. MOTUS is the vessel that carries these ideals, it was built to drive continued improvement in application and education.. PerformTex could not be more proud of aligning and offering our complete support of the MOTUS system, states John Jarvis, marketing director for PerformTex Products LLC. By working with two, of whom many consider to be true innovators, leaders and visionarys within the world in regards to kinesiology taping and myofascial therapy treatment, we finally have a system in place created by practitioners for practitioners. We, as a team, will strive to offer the very best and truly offer actual advancement, in not only our product line, but educational offerings.. For more information on MOTUS Therapeutic Methods and its ...
The results of this study showed that, in patients with acute AC-LAO that was refractory to stentriever thrombectomy, permanent stenting achieved mTICI 2b-3 recanalization in 83.3% of cases, and the stent group had a significantly higher favorable outcome rate than the nonstent group without an increase in sICH or mortality. This suggests that permanent stenting may be a rescue treatment modality for stentriever-failed AC-LAO. The efficacy and safety of permanent stenting for recanalization of acute stroke were evaluated in several previous studies.10-14 In the era of stentriever thrombectomy, however, the efficacy of permanent stenting for stentriever-failed AC-LAO has remained unclear. To our knowledge, this is the first report comparing an SG with an NSG in patients with stentriever-failed AC-LAO, although the study performed was retrospective in nature.. In ≈30% of AC-LAO cases, stentriever thrombectomy failed to achieve mTICI 2b-3 recanalization.9 In 25.5% of the AC-LAO cases in this ...
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Migraine Rescue treatment is an integral part of effective Migraine management (such as NSAIDs). Discussion of possible migraine rescue treatments.
Comparison of one-year clinical outcomes between intravascular ultrasound-guided versus angiography-guided implantation of drug-eluting stents for left main lesions: a single-center analysis of a 1,016-patient cohort Xiao-Fei Gao,1,* Jing Kan,1,* Yao-Jun Zhang,1,2 Jun-Jie Zhang,1 Nai-Liang Tian,1 Fei Ye,1 Zhen Ge,1 Ping-Xi Xiao,1 Feng Chen,3 Gary Mintz,4 Shao-Liang Chen1 1Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Peopleâ s Republic of China; 2Thorax Center, Erasmus Medical Center, Rotterdam, the Netherlands; 3Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Peopleâ s Republic of China; 4Division of Cardiology, Cardiovascular Research Foundation, Columbia University, New York, NY, USA *These authors contributed equally contributed to this work Background: The importance of intravascular ultrasound (IVUS)-guided stenting of the unprotected left main coronary artery (ULMCA) remains controversial
Calamine lotion is an over-the-counter (OTC) medication that can help relieve mild itchiness, or pruritus. It can be used to treat a variety of skin irritations from poison ivy and chigger bites, to minor burns. Learn more about calamine: what its made of, how to use, and potential side effects.
A Phase II, Single Arm, Multicentre Open Label Trial to Determine the Safety and Efficacy of Tisagenlecleucel in Pediatric Subjects With Relapsed or Refractory Mature B-cell Non-Hodgkin Lymphoma (NHL)
In conjunction with the National Multiple Sclerosis Society (NMSS) the Difficult Cases Webinar is an informal webinar designed to help clinicians, investigators, researchers and other personnel discuss difficult cases of pediatric MS or other suspected demyelinating diseases. Once a month individuals participate in a one hour call/webinar to help the presenter come up with possible diagnoses, treatments, or solutions to their difficult cases. If you are interested in joining the Difficult Cases Webinar and would like to receive reminders about upcoming calls then please contact Liz Brown ([email protected]).. Difficult Case Webinar Flyer. ...
The average treatment effect (ATE) is a measure used to compare treatments (or interventions) in randomized experiments, evaluation of policy interventions, and medical trials. The ATE measures the difference in mean (average) outcomes between units assigned to the treatment and units assigned to the control. In a randomized trial (i.e., an experimental study), the average treatment effect can be estimated from a sample using a comparison in mean outcomes for treated and untreated units. However, the ATE is generally understood as a causal parameter (i.e., an estimate or property of a population) that a researcher desires to know, defined without reference to the study design or estimation procedure. Both observational studies and experimental study designs with random assignment may enable one to estimate an ATE in a variety of ways. Originating from early statistical analysis in the fields of agriculture and medicine, the term treatment is now applied, more generally, to other fields of ...
WASHINGTON, March 22, 2016 /PRNewswire-USNewswire/ -- PCORI Board Authorizes $22 Million to Compare Treatment Options for Chronic Low Back Pain. Also...
Background: Among ambulatory patients with heart failure (HF), hospital admission is associated with higher subsequent mortality. HF is the leading cause of 30-day all-cause readmission, reduction of which is a goal of the Affordable Care Act. We examined the association of 30-day all-cause readmission with subsequent all-cause mortality in a propensity-matched cohort of hospitalized HF patients.. Methods: Of the 8049 Medicare beneficiaries hospitalized for HF and discharged alive from 106 U.S. hospitals (1998-2001), 7578 were alive 30-day post-discharge, of which 1519 had 30-day all-cause readmission. Using propensity scores for 30-day all-cause readmission, we assembled a matched cohort of 1516 pairs of patients with and without 30-day all-cause readmission, balanced on 34 baseline characteristics.. Results: During 2-12 months of post-discharge follow-up, all-cause mortality occurred in 41% and 27% of matched patients with and without 30-day all-cause readmission, respectively (HR, 1.68; 95% ...
Objectives: Prompt Mental Health Care (PMHC) is the Norwegian version of the Englands Improving Access to Psychological Therapies (IAPT). Both programs have been associated with substantial symptom reductions from pre- to post-treatment. The present study extends these findings by investigating symptom levels at 12 months post-treatment, as well as treatment outcome in relation to low- vs. high-intensity treatment forms. Design and Outcome Measures: A prospective cohort design was used. All participants (n = 1530) were asked to complete the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 questionnaire (GAD-7) at baseline, before each session during treatment, at final treatment, and at 12 months post-treatment. Cohens d was used as effect size measure. Sensitivity analyses were conducted to examine the impact of the high missing data rates at post-treatment (≈44%) and 12 months post-treatment (≈58%). Results: A large symptom reduction was seen from baseline to ...
TY - JOUR. T1 - Effect of In-Hospital Initiation of Lipid-Lowering Therapy on Six-Month Outcomes in Patients With Acute Ischemic Stroke or Transient Ischemic Attack. AU - Yeh, Poh Shiow. AU - Lin, Huey Juan. AU - Bai, Chyi Huey. AU - Hsieh, Fang I.. AU - Ke, Der Shin. AU - Li, Yi Heng. PY - 2010/5/15. Y1 - 2010/5/15. N2 - Early lipid-lowering therapy (LLT) has demonstrated clinical benefits in patients with acute coronary syndrome; however, little is known about early LLT in patients with stroke. We evaluated the effect of in-hospital initiation of LLT on the clinical outcomes of patients with stroke. The Taiwan Stroke Registry prospectively collected data from patients with acute ischemic stroke or transient ischemic attack. By July 31, 2008, 16,704 adult patients without previous LLT had been admitted and survived to discharge. The study end point was the composite outcome of recurrent stroke, ischemic heart disease, and all-cause death. We examined the effect of LLT at discharge on the ...
TY - JOUR. T1 - Labour Market Status at Ages 50-64 and All-Cause Mortality at Ages 65-70: A Longitudinal Study from Finland. AU - Klein, Julia. AU - Saarela, Jan. PY - 2019. Y1 - 2019. N2 - Individuals labour market status and health are known to be highly correlated. To investigate this association beyond prime working ages, we study how all-cause mortality at ages 65-70 relates to different labour market positions at ages 50-64. The data stem from random samples of the Finnish population, which make it possible to follow 33,000 individuals in the period 1987-2011. Hazard models are estimated to quantify the associations. For both men and women, disability pensioners have a hazard of dying at age 65+ that is approximately twice that of persons who were employed, and this ratio still exceeds 1.5 when socioeconomic and demographic variables are included. Also male unemployment, but not female, is associated with an elevated mortality risk, but this interrelation depends greatly on socioeconomic ...
Are patient-reported outcomes useful in post-treatment follow-up care for women with early breast cancer? A scoping review Cathrine Lundgaard Riis,1-3 Troels Bechmann,1,2 Pernille Tine Jensen,4,5 Angela Coulter,2,3,6 Karina Dahl Steffensen1-3 1Department of Oncology, Vejle Hospital, Vejle, Denmark; 2Institute of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; 3Center for Shared Decision Making, Vejle, Denmark; 4Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark; 5Department of Clinical Research, University of Southern Denmark, Odense, Denmark; 6Nuffield Department of Population Health, University of Oxford, Oxford, UK Background: Patient-reported outcomes (PROs) are frequently used to evaluate treatment effects and quality of life in clinical trials. The application of PROs in breast cancer clinics is evolving but their use to generate real-time information for use in follow-up care is uncommon. This proactive use
To systematically assess adherence of randomised trials in surgery to Consolidated Standards of Reporting Trials (CONSORT) guidelines for non-pharmacological treatments (NPT). Surgical trials are considered more difficult to design and execute than pharmacological trials. Furthermore, the original CONSORT statement does not address some aspects that are vital to the transparent reporting of surgical trials. The CONSORT-NPT extension was designed to address these issues but adherence in medical and surgical journals has not been assessed.Cross-sectional study.We identified eight general medical and eight surgical journals, indexed in PubMed and published in 2011, with the highest impact factors in their respective categories.Adherence to CONSORT statement and CONSORT-NPT extension items.We identified 54 surgical trials (22 published in medical journals and 32 in surgical journals). There were eight items for which there was less than 30% overall compliance (seven were specific to the CONSORT-NPT
TY - JOUR. T1 - Colorectal cancer. T2 - How emerging molecular understanding affects treatment decisions. AU - Sridharan, Meera. AU - Hubbard, Joleen M.. AU - Grothey, Axel. PY - 2014/2/15. Y1 - 2014/2/15. N2 - The medical treatment of metastatic colorectal cancer (mCRC) has advanced significantly over the last 10 years as the result of the introduction of several active cytotoxic and biologic agents into standard clinical practice. Several recent phase III trials reported median overall survival data exceeding 30 months, an achievement inconceivable only 5 years ago. The first major step forward in the medical management of mCRC was provided by the addition of irinotecan and oxaliplatin to fluorouracil-based therapy; this increased survival from about 12 months to about 20 months. The introduction of biologic agents such as vascular endothelial growth factor inhibitors and epidermal groTawth factor inhibitors further increased survival-to more than 2 years in prospective trials. Recently, an ...
TY - JOUR. T1 - Contemporary Management of Critical Limb Ischemia the BEST Is Yet to Come. AU - Laird, John R.. AU - Singh, Gagan. AU - Armstrong, Ehrin J.. PY - 2016/4/26. Y1 - 2016/4/26. KW - big data. KW - critical limb ischemia. KW - national inpatient sample. KW - peripheral artery disease. UR - http://www.scopus.com/inward/record.url?scp=84962178621&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84962178621&partnerID=8YFLogxK. U2 - 10.1016/j.jacc.2016.02.041. DO - 10.1016/j.jacc.2016.02.041. M3 - Comment/debate. VL - 67. SP - 1914. EP - 1916. JO - Journal of the American College of Cardiology. JF - Journal of the American College of Cardiology. SN - 0735-1097. IS - 16. ER - ...
Two protestors (of whom one is handicapped) injured during Fridays lathicharge were moved to Bombay Hospital from GT Hospital on Saturday after they alleged that they experienced poor treatment and negligent health care at GT Hospital, reports Karthik Balasubramanian.
TY - JOUR. T1 - A retrospective multicenter study on long-term prevalence of chronic pain after cardiac surgery. AU - Claudio, Marcassa. AU - Pompilio, Faggiano. AU - Cesare, Greco. AU - Marco, Ambrosetti. AU - Luigi, Temporelli Pier. PY - 2015/11/11. Y1 - 2015/11/11. N2 - Background There are limited data on sternotomy as a cause of chronic postsurgical pain, mainly restricted to 1 year after surgery. Aims To assess the prevalence of chronic poststernotomy pain and its interference on daily living. Methods In three groups of patients, a standardized telephone interview was obtained at 3 months (nU313), 1 year (nU313), and 3 years (nU319) following the rehabilitation program after cardiac surgery, in 11 rehabilitation centers. Presence, site, and the severity and interference of pain on selected daily living items were assessed. Results The prevalence of pain after cardiac surgery was 35.3% in the 3-month group, 26.8% in the 1-year group, and 19.8% in the 3-year group (P. AB - Background There ...
The study evaluated the effects of a combination of bariatric procedure with intensive medical therapy (IMT) versus intensive medical therapy alone based o
PURPOSE A prolonged time to treatment initiation (TTI) correlates with an adverse prognosis in different cancer types including resectable pancreatic cancer (PC). Only limited evidence on the correlation between TTI and prognosis in advanced PC exists. METHODS Consecutive PC patients (n = 368) who were diagnosed or treated at our high-volume comprehensive cancer center were included in a prospectively maintained database. We retrospectively analyzed time from first imaging showing advanced PC to initiation of palliative first-line chemotherapy. Lead time bias and waiting time paradox were addressed by landmark analysis and correlation of tumor burden with TTI. RESULTS Two hundred and ninety-seven patients met the pre-specified in- and exclusion criteria of our study. Median TTI was 29~days (range: 1-124 days). Most common reasons for prolonged TTI (, 21 days) were referral from an external treatment center (39%) and a second biopsy (31%). A TTI above the median-, 75th or 90th percentile (43 or ...
CI, confidence interval; CR, complete response; PR, partial response; SD, stable disease; NE, not estimable. i. Enhertu 6.4 mg/kg.. ii. As assessed by independent central review.. iii. ORR is (CR + PR).. iv. DCR is (CR + PR + SD).. Patients were treated with a median of two prior lines of therapy (1-6) with most receiving platinum-based chemotherapy (90.5%) and anti-PD-1 or PD-L1 treatment (54.8%). Median treatment duration was 7.76 months (0.7-14.3) with a median duration of follow-up of 8.0 months (1.4-14.2). As of data cut-off on 25 November 2019, 45.2% of patients with HER2m metastatic NSCLC remained on treatment with Enhertu.. The overall safety and tolerability profile of Enhertu in DESTINY-Lung01 was consistent with that seen in the Phase I lung cancer trial and previously reported Enhertu trials.4 The most common Grade 3 or higher treatment-emergent adverse events were decreased neutrophil count (26.2%) and anaemia (16.7%). There were five cases (11.9%) of confirmed treatment-related ...
BACKGROUND AND OBJECTIVE: Following stroke, it is common to exhibit motor impairments and decreased use of the upper limb. The objective of the present study was to evaluate forced use on arm function during the subacute phase after stroke.. DESIGN: A comparison of standard rehabilitation only and standard rehabilitation together with a restraining sling was made through a randomized, nonblinded, clinical pilot trial with assessments before intervention, after intervention, and at 1- and 3-month follow-ups.. SETTING: The present study took place at the departments of rehabilitation medicine, geriatrics, and neurology at a university hospital.. PARTICIPANTS: A convenience sample of 30 people 1 to 6 months (mean, 2.4 mo) after stroke was randomized into 2 groups (forced-use group and standard training group) of 15 people each. Twenty-six participants completed the 3-month follow-up.. INTERVENTION: All participants received their standard rehabilitation program with training 5 days per week for 2 ...
Whilst there is much current data on early outcomes after Coronary artery bypass grafting(CABG), there is relatively little data on medium term outcomes in the current era. The purpose of this study is to present a single surgeon series comprising of all first time CABG patients operated on with the technique of cross clamp fibrillation from Feb-1996 to through to Jan-2003, and to seek risk factors for medium term mortality in these patients. Data was collected from Hospital Episode Statistics and departmental patient administration and tracking systems and cross checked using database techniques. Patient outcomes were searched using the National Health Service strategic tracing service. Mean follow up was 5.3 years(0-9.4 years) and was complete for all patients. 30-day survival was 98.4%, 1-year survival 95% and 8-year survival 79%. Cox-regression analysis revealed that several modifiable pre-operative risk factors remain significant predictors of medium term mortality, including Diabetes(Hazard Ratio
Inclusion Criteria: - Patients must have histologic evidence of relapsed or refractory B-cell ALL - Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less - Philadelphia chromosome positive (Ph+) patients must be refractory to or intolerant of standard tyrosine kinase inhibitor therapy - Patients must be able to consume oral medication - Patients must have recovered to =, grade 1 or stabilized from the toxic effects of any prior chemotherapy (except alopecia) - Creatinine clearance (CrCL) ,= 60 mL/min/1.73 m^2 calculated by Cockcroft-Gault - Total bilirubin , 1.5 x upper limit of normal (ULN) - Negative serum or urine pregnancy test for women with child-bearing potential - Patients must be able to sign consent and be willing and able to comply with scheduled visits, treatment plan, procedures, and laboratory testing Exclusion Criteria: - Patients must not have evidence of active central nervous system (CNS) disease - Patients must not be receiving any ...
January 26, 2018-Medtronic announced the initiation of its investigational device exemption (IDE) study that will evaluate the safety and effectiveness of the companys Abre venous self-expanding stent system in patients with iliofemoral venous outflow obstruction.. According to the company, the multicenter, single-arm study intends to enroll 200 patients with deep venous disease at up to 35 sites throughout the United States and Europe. The primary efficacy endpoint will evaluate patency at 12 months, which is defined by freedom from occlusion and freedom from clinically driven target lesion revascularization. The primary safety endpoint will evaluate the incidence of composite major adverse events at 30 days after stenting of an obstruction in the iliofemoral venous segment.. The Abre stent is premounted on a 9-F delivery system and features a nitinol stent with a triaxial shaft design. The stent utilizes an open-cell design with three connection points between the cells that are intended to ...
Purpose: To review the risk of local recurrence and impact of salvage therapy after Watch and Wait for rectal cancer with complete clinical response (cCR) after chemoradiation therapy (CRT). Methods and Materials: Patients with cT2-4N0-2M0 distal rectal cancer treated with CRT (50.4-54 Gy + 5-fluorouracil-based chemotherapy) and cCR at 8 weeks were included. Patients with cCR were enrolled in a strict follow-up program with no immediate surgery (Watch and Wait). Local recurrence-free survival was compared while taking into account Watch and Wait strategy alone and Watch and Wait plus salvage. Results: 90 of 183 patients experienced cCR at initial assessment after CRT (49%). When early tumor regrowths (up to and including the initial 12 months of follow-up) and late recurrences were considered together, 28 patients (31%) experienced local recurrence (median follow-up time, 60 months). Of those, 26 patients underwent salvage therapy, and 2 patients were not amenable to salvage. In 4 patients, ...
Furiex Pharmaceuticals has reported top-line results from the phase II trial of the investigational drug PPD-10558 in patients with statin-associated myalgia, or SAM. PPD-10558 did not meet its primary efficacy endpoint in this randomized, double-blind, proof-of-concept study. The study enrolled patients with high cholesterol and a prior history of SAM, and evaluated recurrence rates for SAM over a twelve-week treatment period across the following three different treatment regimens: placebo; PPD-10558; and atorvastatin (Lipitor). Patients did not report any significant differences in muscle symptoms, nor did they drop out due to SAM in significantly different percentages, among the three regimens. As expected, however, PPD-10558, a novel statin, did significantly lower LDL-cholesterol compared with placebo, and the compound also had a favorable safety profile.. Furiex acquired an exclusive license rights in 2007 from Ranbaxy Laboratories to develop, manufacture and market its novel statin ...
The therapeutic alliance has demonstrated an association with favorable psychotherapeutic outcomes in the treatment of eating disorders (EDs). However, questions remain about the inter-relationships between early alliance, early symptom improvement, and treatment outcome. We conducted a meta-analysis on the relations among these constructs, and possible moderators of these relations, in psychosocial treatments for EDs. Twenty studies met inclusion criteria and supplied sufficient supplementary data. Results revealed small-to-moderate effect sizes, βs = 0.13 to 0.22 (p , .05), indicating that early symptom improvement was related to subsequent alliance quality and that alliance ratings also were related to subsequent symptom reduction. The relationship between early alliance and treatment outcome was partially accounted for by early symptom improvement. With regard to moderators, early alliance showed weaker associations with outcome in therapies with a strong behavioral component relative to ...
THOUSAND OAKS, Calif., June 5, 2010 /PRNewswire via COMTEX/ --Amgen (Nasdaq: AMGN) today announced detailed results from a Phase 3, head-to-head trial which compared the efficacy and safety of denosumab versus Zometa(R) (zoledronic acid) in 1,901 patients with hormone-refractory prostate cancer and bone metastases. The study met its primary and secondary endpoints and demonstrated denosumabs superiority over Zometa in delaying or preventing skeletal related events (SREs). These statistically significant results will be presented in an oral session on June 6, 2010 at the American Society of Clinical Oncology (ASCO) 2010 Annual Meeting in Chicago (Late Breaking Abstract Number #LBA4507). In patients with skeletal metastases, the growing cancer cells weaken and destroy the bone around the tumor. This can result in a number of serious complications, collectively called SREs, comprising fracture, radiation to bone, surgery to bone or spinal cord compression. All can be serious complications for ...
Outcomes in relation with selected kinds of treatment[edit]. Large-scale international reviews of scientific studies have ... One issue with trials is what to use as a placebo treatment group or non-treatment control group. Often, this group includes ... These incorporate subjective treatments (after Beck), behavioral treatments (after Skinner and Wolpe) and additional time- ... medical treatment"). The Oxford English Dictionary defines it now as "The treatment of disorders of the mind or personality by ...
Outcome of nonoperative treatment[edit]. Failure of nonoperative treatment leading to functional impairment and anatomic ... "Comparison of treatment outcomes between nonsurgical and surgical treatment of distal radius fracture in elderly: a systematic ... Outcome[edit]. World Health Organization (WHO) divides outcomes into three categories: impairment, disabilities, and handicaps ... Significant advances have been made in ORIF treatments. Two newer treatment are fragment-specific fixation and fixed-angle ...
Outcome and treatment[edit]. Defibrillator training kit. Most cases are fatal. Automated external defibrillators have helped ...
Treatment. Blood pressure control, surgery, ventricular drain [1]. Prognosis. 20% good outcome[2]. ... Treatment[edit]. Treatment depends substantially on the type of ICH. Rapid CT scan and other diagnostic measures are used to ... a b c d e f g h eMedicine Specialties , Neurology , Neurological Emergencies , Intracranial Haemorrhage: Treatment & Medication ... Treatment should typically be carried out in an intensive care unit.[1] Guidelines recommended decreasing the blood pressure to ...
Alexithymia influences treatment outcome.[110] Recovery is also viewed on a spectrum rather than black and white. According to ... Treatment[edit]. There is no conclusive evidence that any particular treatment for anorexia nervosa works better than others; ... Treatment. Cognitive behavioral therapy, hospitalisation to restore weight[7][1]. Prognosis. 5% risk of death over 10 years[3][ ... however, there is enough evidence to suggest that early intervention and treatment are more effective.[96] Treatment for ...
Nevertheless the treatment of this type of meningioma remains a challenge with relatively frequent poor outcomes.[20] ... Joung H. Lee (2008-12-11). Meningiomas: Diagnosis, Treatment, and Outcome. Springer Science & Business Media. pp. 3-13. ISBN ... Treatment[edit]. Observation[edit]. Observation with close imaging follow-up may be used in select cases if a meningioma is ... Newton HB (2007). "Hydroxyurea chemotherapy in the treatment of meningiomas". Neurosurg Focus. 23 (4): E11. doi:10.3171/foc-07/ ...
5 Treatment and prognosis *5.1 Treatment and management. *5.2 Outcome and prognosis ... One treatment methodogy that is very promising for the treatment of camptocormia is deep brain stimulation. Previously, deep ... Outcome and prognosis[edit]. This condition can lead to excess pressure on the spine, causing pain and discomfort.[4] If the ... Treatment of the underlying cause of the disease can alleviate the condition in some individuals with secondary BSS. Other ...
Moos, R.H.; Finney, J.W.; Cronkite, R.C. (1990). Alcoholism Treatment: Context, Process and Outcome. New York: Oxford ... "Ambrosia Treatment Center. 2016-02-11. Retrieved 14 August 2017.. *^ Gomberg, Edith S Lisansky (1989). Gomberg, Edith S (ed.). ... Sperry, M.D., Ph.D, Len (13 May 2013). Handbook of Diagnosis and Treatment of DSM-IV Personality Disorders. Kentucky: Routledge ... An empirical review of clinical folklore". Journal of Substance Abuse Treatment. 10 (3): 303-16. doi:10.1016/0740-5472(93)90079 ...
Moos, R.H.; Finney, J.W.; Cronkite, R.C. (1990). Alcoholism Treatment: Context, Process and Outcome. New York: Oxford ... "Ambrosia Treatment Center. Retrieved 14 August 2017.. *^ Gomberg, Edith S Lisansky (1989). Gomberg, Edith S, ed. "On Terms Used ... Sperry, M.D., Ph.D, Len (13 May 2013). Handbook of Diagnosis and Treatment of DSM-IV Personality Disorders. Kentucky: Routledge ... Not all mental health professionals agree about standard methods of treatment.[31] Caring for an individual with a physical ...
Alternative treatments[change , change source]. While there are many alternative treatments used for the common cold, there is ... Outcome[change , change source]. The common cold is generally mild and goes away on its own with most symptoms improving in one ... The unit was closed in 1989, two years after it completed research of zinc gluconate lozenges in the prevention and treatment ... Al-Nakib, W; Higgins, PG; Barrow, I; Batstone, G; Tyrrell, DA (Dec 1987). "Prophylaxis and treatment of rhinovirus colds with ...
Surface osteosarcomas: Diagnosis, treatment and outcome. „Indian J Orthop". 48 (3), s. 255-61, May 2014. DOI: 10.4103/0019- ... Osteosarcoma of the jaw/craniofacial region: outcomes after multimodality treatment. „Cancer". 115 (14), s. 3262-70, Jul 2009. ... Periosteal osteosarcoma-a European review of outcome. „Eur J Cancer". 41 (18), s. 2806-11, Dec 2005. DOI: 10.1016/j.ejca. ... Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma. „Cancer". ...
To classify postoperative outcomes for epilepsy surgery, Jerome Engel proposed the following scheme,[1] the Engel Epilepsy ... Engel, Jerome (1993). Surgical Treatment of the Epilepsies. Lippincott Williams & Wilkins. ISBN 0-88167-988-7.. ... "Engel Epilepsy Surgery Outcome Scale". Massachusetts General Hospital. Retrieved 31 March 2014.. ... As is the case for all current methods of reviewing epilepsy surgery outcomes, the Engel classification system has subjective ...
Psychotherapy may improve outcomes. Evidence for acupressure is poor. While vomiting in pregnancy has been described as early ... After rehydration, treatment focuses on managing symptoms to allow normal intake of food. However, cycles of hydration and ... Treatment includes drinking fluids and a bland diet. Recommendations may include electrolyte-replacement drinks, thiamine, and ... While previously known as a common cause of death in pregnancy, with proper treatment this is now very rare. Those affected ...
Onen A (December 2007). "Treatment and outcome of prenatally detected newborn hydronephrosis". Journal of Pediatric Urology. 3 ... Treatment of hydronephrosis focuses upon the removal of the obstruction and drainage of the urine that has accumulated behind ... Therefore, the specific treatment depends upon where the obstruction lies. Acute obstruction of the upper urinary tract is ...
Early diagnosis improves outcomes.[1] Treatment is supportive.[1] Mannitol may be used to help with the brain swelling.[2] ... Treatment[edit]. Treatment is supportive.[1] Mannitol may be used to help with the brain swelling.[2] ...
"Treatment & Outcomes of Oral Candidiasis". cdc.gov. February 13, 2014. Retrieved 28 December 2014.. ... "Treatment & Outcomes of Genital / Vulvovaginal Candidiasis". cdc.gov. February 13, 2014. Archived from the original on 29 ... only external treatments - such as a cream - can be recommended for penile treatment.[67] A one-time dose of fluconazole by ... Systemic treatment with antifungals by mouth is reserved for severe cases or if treatment with topical therapy is unsuccessful ...
... during treatment) and outcome measures (after termination of treatment).[29] The article by Stefan G. Hofmann and David H. ... In contrast, treatment method accounted for roughly 1% of outcome variance.[35] ... Kazdin, Alan E (June 2005). "Treatment outcomes, common factors, and continued neglect of mechanisms of change". Clinical ... and treatment fit variables in psychotherapy outcome". Journal of Psychotherapy Integration. 22 (3): 255-281. doi:10.1037/ ...
Saal JA, Saal JS (April 1989). "Nonoperative treatment of herniated lumbar intervertebral disc with radiculopathy. An outcome ... Treatment[edit]. Ideally, effective treatment aims to resolve the underlying cause and restores the nerve root to normal ... "Pinched Nerve Symptoms & Treatment , Advanced Neurosurgery". Advanced Neurosurgery Associates. Retrieved 2020-12-14.. ... Conservative treatment may include bed rest, physical therapy, or simply continuing to do usual activities; for pain, ...
Early treatment increases the chance of a good outcome.[2] Treatment consists of stabilizing the person, followed by the use of ... Treatment[edit]. Methanol poisoning can be treated with fomepizole, or if unavailable, ethanol.[6][12][13] Both drugs act to ... Long-term outcomes may include blindness and kidney failure.[1] Toxicity and death may occur even after drinking a small amount ... Additional treatment may include sodium bicarbonate for metabolic acidosis, and hemodialysis or hemodiafiltration to remove ...
Walker KM, Pope J (August 2012). "Treatment of systemic sclerosis complications: what to use when first-line treatment fails--a ... Outcome depends on the extent of disease.[3] Those with localized disease generally have a normal life expectancy.[7] In those ... Treatment[edit]. No cure for scleroderma is known, although relief of symptoms is often achieved; these include the:[13][31] ... Systemic disease-modifying treatment with immunosuppressants is often used.[16][32][33][34][35][36] Immunosuppressants used in ...
2-Year Outcomes From the NIMH RAISE Early Treatment Program". The American Journal of Psychiatry. 173 (4): 362-372. doi:10.1176 ... The approach is similar to assertive community treatment, but with an increased focus on the engagement and treatment of this ... community-oriented treatment of early psychosis an economically viable method of improving outcome?". Acta Psychiatr Scand. 100 ... The aim is to reduce the usual delays to treatment for those in their first episode of psychosis. The provision of optimal ...
... this may reflect poor treatment of the Church.[11][12] In 715, the Mercians under Ceolred fought a battle at "Woden's Barrow", ... the outcome of this battle was not recorded. ...
With appropriate treatment, outcomes are good. Cleft lip and palate occurs in about 1 to 2 per 1000 births in the developed ... Treatment procedures can vary between craniofacial teams. For example, some teams wait on jaw correction until the child is ... Cleft lip and palate is very treatable; however, the kind of treatment depends on the type and severity of the cleft. Most ... Allowing an entire team to care for a child throughout their cleft lip and palate treatment (which is ongoing) allows for the ...
No pharmacological treatment I 7. Treatment goal I 8. Socio-healthcare system. N 0. Need, unspecified N 1. Treatment based on ... Outcome. I 0. Information / Health education, unspecified I 1. Situation / reason for encounter I 2. Health problem I 3. ... Treatment based on public health issues N 4. Prevention N 5. Healthcare provision N 6. Complementary test for treatment control ... Complementary examination I 4. Risk I 5. Pharmacological treatment I 6. ...
Treatment[edit]. All persons suspected of Lassa fever infection should be admitted to isolation facilities and their body ... "A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy". BMJ. 297 (6648): 584-7. ... Early and aggressive treatment using ribavirin was pioneered by Joe McCormick in 1979. After extensive testing, early ... Because of treatment with ribavirin, fatality rates are continuing to decline.[26][27] ...
... and Treatment Outcomes". Circulation. Arrhythmia and Electrophysiology. 10 (11): e005579. doi:10.1161/CIRCEP.117.005579. PMID ... Comorbidity treatment[edit]. For people who have both atrial fibrillation and obstructive sleep apnea, observational studies ... Both methods have similar outcomes.[104] Rate control lowers the heart rate closer to normal, usually 60 to 100 bpm, without ... Treatment. Lifestyle modifications, rate control, rhythm control, anticoagulation[5]. Frequency. 2.5% (developed world), 0.5% ( ...
Treatment may include speech therapy or extra help with schoolwork. Outcomes are generally good. Prevention is not possible. ... ISBN 0-385-50993-6. Blumer, Dietrich; Migeon, Claude (February 1975). "Hormone and hormonal agents in the treatment of ... Genetic disorders and the fetus : diagnosis, prevention and treatment (4th ed.). Baltimore: Johns Hopkins University Press. pp ... prevention and treatment (6th ed.). Oxford: Wiley-Blackwell. pp. 273-312. ISBN 1-4051-9087-6. The addition of a Y chromosome to ...
"Levels of Evidence for the Outcome of Nonsurgical Endodontic Treatment". Journal of Endodontics. 31 (9): 637-646. doi:10.1097/ ... Root canal treatment[edit]. Main article: Root canal treatment. Root canal treatment is a dental procedure used to treat ... The root canal treatment procedure is often carried out over single[3] or multiple appointments.[4] Root canal treatment ... Treatment is provided based on the severity of the injury.[10] Tooth discolouration as a result of root canal treatment can ...
If medical treatment does not reduce a patient's urinary symptoms, a TURP may be considered following a careful examination of ... Outcome is considered excellent for 80-90% of BPH patients. BPH is normally initially treated medically. This is done through ... This is considered the most effective treatment for BPH. This procedure is done with spinal or general anaesthetic. A triple ... Postoperative complications include Bleeding (most common). Bleeding may be reduced by pre-treatment with an anti-androgen such ...
Outcomes are generally good with treatment.[2]. The rate of ectopic pregnancy is about 1 and 2% that of live births in ... Early treatment of an ectopic pregnancy with methotrexate is a viable alternative to surgical treatment[33] which was developed ... Treatment[edit]. Expectant management[edit]. Most women with a PUL are followed up with serum hCG measurements and repeat TVS ... Salpingectomy as a treatment for ectopic pregnancy is one of the common cases when the principle of double effect can be used ...
PIR has a poorer resolution than NIR and this treatment typically focuses on more global increases in cerebral blood flow.[3] ... Stokes, D.A. & Lappin, M.S.. (2010). Neurofeedback and biofeedback with 37 migraineurs: a clinical outcome study. Behavioral ... The myriad of studies exploring the potency of neurotherapy as a treatment for ASD have primarily involved EEG and QEEG, but ... 70% of sufferers saw a 50% or more reduction in their migraines following combined neurotherapy and drug treatment, as opposed ...
Poupon RE, Balkau B, Eschwège E, Poupon R (May 1991). "A multicenter, controlled trial of ursodiol for the treatment of primary ... "Efficacy, patient-reported outcomes and safety profile of ATX-101 (deoxycholic acid), an injectable drug for the reduction of ... Treatment with ursodeoxycholic acid has been used for many years in these cholestatic disorders.[24][25] ... Stones may recur when treatment is stopped. Bile acid therapy may be of value to prevent stones in certain circumstances such ...
The treatment of bilateral coronal synostosis shows a high degree of overlap with treatment of unilateral coronal synostosis; ... Panchal J, Marsh JL, Park TS, Kaufman B, Pilgram T, Huang SH (May 1999). "Sagittal craniosynostosis outcome assessment for two ... TreatmentEdit. The primary goal of surgical intervention is to allow normal cranial vault development to occur.[42] This can be ... The treatment of pansynostosis comprises the expansion of the anterior cranial vault, as well as the posterior cranial vault.[ ...
Metformin is generally recommended as a first line treatment as there is some evidence that it decreases mortality;[7][25][104] ... No major organization recommends universal screening for diabetes as there is no evidence that such a program improve outcomes. ... O'Gorman DJ, Krook A (September 2011). "Exercise and the treatment of diabetes and obesity". The Medical Clinics of North ... Type 2 diabetes is largely preventable by staying a normal weight, exercising regularly, and eating properly.[1] Treatment ...
However, the number of empirical studies on community webs is on the rise and the mathematical treatment of food webs using ... and laws of food web behaviours relative to observable outcomes. "Food web theory centers around the idea of connectance."[65]: ...
Treatment[edit]. Ice is applied to relieve pain and swelling. Any open wounds are cleansed to avoid infection. ... For most fractures with less than 70 degrees of angulation, buddy taping and a tensor bandage resulted in similar outcomes to ... Treatment. Buddy taping and a tensor bandage, reduction and splinting[4][3]. ... For most fractures with less than 70 degrees of angulation, buddy taping and a tensor bandage resulted in similar outcomes to ...
In short, even innocuous treatments can indirectly produce negative outcomes.[171] Between 2001 and 2003, four children died in ... a) Misinterpreted natural course - the individual gets better without treatment. b) Placebo effect or false treatment effect - ... 2003). "Open versus hidden medical treatments: The patient's knowledge about a therapy affects the therapy outcome". Prevention ... Treatment delay. Alternative medicine may discourage people from getting the best possible treatment.[169] Those having ...
Treatment and management of COVID-19. U. *List of unproven methods against COVID-19 ... neurological, psychological and other mental health outcomes. *Pregnancy. *Non-COVID-19-related health issues ...
van der Poll T, Opal SM (2009). "Pathogenesis, treatment, and prevention of pneumococcal pneumonia". Lancet. 374 (9700): 1543- ... "The Role of Innate Immune Responses in the Outcome of Interspecies Competition for Colonization of Mucosal Surfaces". PLoS ... Main article: Pneumococcal infection § Treatment. Resistant Pneumococci strains are called penicillin-resistant Pneumocci (PRP) ...
... two treatments (REGN-EB3 and mAb114) are associated with improved outcomes.[10] Supportive efforts also improve outcomes.[1] ... While there is no approved[by whom?] treatment for Ebola as of 2019[update],[9] two treatments (REGN-EB3 and mAb114) are ... Treatment is primarily supportive in nature.[135] Early supportive care with rehydration and symptomatic treatment improves ... "FDA Approves First Treatment for Ebola Virus". U.S. Food and Drug Administration (FDA) (Press release). 14 October 2020. ...
TreatmentEdit. The first-line treatment of Cushing's disease is surgical resection of ACTH-secreting pituitary adenoma; this ... Patients older than 64 years were more likely to have an adverse outcome and prolonged hospital stay. Women were 0.3 times less ... One of the major complications of this treatment is progression of Nelson's syndrome which is caused by enhance level of tumor ... Ding D, Starke RM, Sheehan JP (May 2014). "Treatment paradigms for pituitary adenomas: defining the roles of radiosurgery and ...
"Journal of Substance Abuse Treatment. 89: 75-86. doi:10.1016/j.jsat.2018.04.002. PMC 5964257. PMID 29706176.. ... "Oregon Study: Medicaid 'Had No Significant Effect' On Health Outcomes vs. Being Uninsured". Forbes. Retrieved April 18, 2019.. ... A 2017 study found that Medicaid expansion, by increasing treatment for substance abuse, "led to a sizeable reduction in the ... Due to the high costs associated with HIV medications, many patients are not able to begin antiretroviral treatment without ...
"Clostridium Infections". Advances in Research and Treatment (2011 ed.). ScholarlyEditions. 9 January 2012. ISBN 9781464960130. ... "Indigenous gray ducks, Anas superciliosa, and introduced mallards, A. platyrhynchos, in New Zealand: processes and outcome of ...
... and aggressive treatment of acne is advocated by some in the medical community to reduce the chances of these poor outcomes.[4] ... Retinoids became a medical treatment for acne in 1943.[84] Benzoyl peroxide was first proposed as a treatment in 1958 and ... hormonal treatments, keratolytic soaps, nicotinamide, retinoids, and salicylic acid.[75] Acne treatments work in at least four ... but data for long-term outcomes, and outcomes in those with severe acne, are sparse;[156] it may have a role for individuals ...
There is no difference in outcomes between embolization and ligation as treatment options, but embolization is considerably ... Treatment[edit]. The flow of blood normally stops when the blood clots, which may be encouraged by direct pressure applied by ... Guarisco JL, Graham HD (1989). "Epistaxis in children: causes, diagnosis, and treatment". Ear Nose Throat J. 68 (7): 522, 528- ... The drugs oxymetazoline or phenylephrine are widely available in over-the-counter nasal sprays for the treatment of allergic ...
For his work on the quantitative treatment of biological problems. 1900. Ernst Haeckel. For his long-continued and highly ... On the ground of his South African bionomic researches, in large part undertaken as the outcome of correspondence with Charles ...
This results in a delay of treatment, which can be detrimental to patients in need of immediate medical attention. Most of ... Devkota, Bhimsen (1 December 2010). "Understanding effects of armed conflict on health outcomes: the case of Nepal". BioMed ...
"Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppressive treatment ... High-dose corticosteroids such as prednisone are a standard treatment; however this immuno-suppressive treatment often leads to ... This treatment also has an immunosuppressive effect that prevents rejection of the HSC by the recipient's immune system. The ... Many recipients of HSCTs are multiple myeloma[10] or leukemia patients[11] who would not benefit from prolonged treatment with ...
Treatment of spontaneous abortions[change , change source]. Usually, no treatment is needed for a miscarriage. However, ... "David M. Fergusson, Joseph M. Boden, L. John Horwood" (2007). ""Abortion Among Young Women and Subsequent Life Outcomes"". " ... "The Need for Assessing the Outcome of Common Medical Practices." 1 Ann Rev Pub Health 291 (1980). ... Breast Cancer Research and Treatment 2 (1): 5-73. doi:10.1007/BF01805718. PMID 6216933. ...
Wikipedia articles are not supposed to be pedagogic treatments of their topics. Readers who are interested in learning a ... with a somewhat unsatisfactory outcome, because of a participant with unusual foundational views. --Trovatore (talk) 21:29, 13 ...
Usually the treatment is done in the second trimester of pregnancy, for a woman who had either one or more late miscarriages in ... due to perceived better outcomes and more pregnancies carried to term. A c-section is required for women giving birth with a ... The treatment consists of a strong suture being inserted into and around the cervix early in the pregnancy, usually between ... Cervical cerclage, also known as a cervical stitch, is a treatment for cervical incompetence or insufficiency, when the cervix ...
Treatment[edit]. Patient understanding of the new diagnosis is crucial for their treatment, which requires their active ... Though there is limited evidence, outcomes appear to be relatively poor with a review of outcome studies finding that two ... Describe treatment to help regain control of symptoms. Psychotherapy is the most frequently used treatment, which might include ... the authors point out ways in which this may have biased their outcome data. Outcome was shown to be better in people with ...
"Outcomes of the two treatments were compared using the Wilcoxon-Mann-Whitney two-sample rank-sum test. The treatment effect ( ... Treatment A decreased weight by HLΔ = 5 kg (0.95 CL [2, 9] kg, 2P = 0.02, ρ = 0.58).". However it would be rare to find so ... Consider another hare and tortoise race, with 19 participants of each species, in which the outcomes are as follows, from first ... Bergmann, Reinhard; Ludbrook, John; Spooren, Will P.J.M. (2000). "Different Outcomes of the Wilcoxon-Mann-Whitney Test from ...
Treatment[edit]. The decision to treat is based on a belief that the child will be disabled by being extremely short as an ... final height in children with short stature may be beneficial and could enhance health-related quality of life outcomes, ... barring troublesome side effects and excessive cost of treatments.[7] Cost[edit]. The cost of treatment depends on the amount ... Treatment is expensive and requires many years of injections with human growth hormones. The result depends on the cause, but ...
It has also been found that treatment of tobacco related diseases and the loss of productivity caused therein cost the country ... the evidence that smoking bans improved health outcomes had become more robust, especially with respect to acute coronary ... "Treatment protocols of the lupus nephritis collaborative study of plasmapheresis in severe lupus nephritis. The Lupus ... are viewed by public health experts as an important element in reducing smoking rates and promoting positive health outcomes. ...
... and engaging treatment of Niebuhr's theological and political work that emphasizes his skill in working with scripture and in ...
... adverse pregnancy outcomes are possible with untreated infection; prompt treatment with antibiotics reduces or eliminates this ... Treatment[edit]. Antibiotics are the primary treatment.[2][23] The specific approach to their use is dependent on the ... Facial palsy may resolve without treatment; however, antibiotic treatment is recommended to stop other Lyme complications.[30] ... "Post-Treatment Lyme Disease Syndrome".. Further reading[edit]. *. Richard Ostfeld (2012). Lyme Disease: The Ecology of a ...
There is a wide range of ways to measure treatment outcomes.[90] Chiropractic care, like all medical treatment, benefits from ... "Non-invasive physical treatments for chronic/recurrent headache". Cochrane Database of Systematic Reviews (3): CD001878. doi: ... "Chiropractic treatment available on NHS in Cornwall". BBC. August 13, 2013. Retrieved August 18, 2013.. ... "Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome". Cochrane Database of Systematic Reviews (1 ...
By 1556 Georgius Agricola's treatment of mining and smelting of ore, De Re Metallica, included a detailed description of ... The researchers themselves concluded that the outcome unquestionably demonstrated successful dowsing abilities, but a ...
Gioacchini, FM (January 2015). "Clinical presentation and treatment outcomes of thyroglossal duct cysts: a systematic review". ... "Clinical presentation and treatment outcomes of thyroglossal duct cysts: a systematic review". International Journal of Oral ... and simple cystectomy treatment modalities.[16] The Sistrunk procedure also showed better outcomes concerning the rate of ... Treatment[edit]. Although generally benign, the cyst must be removed if the patient exhibits difficulty in breathing or ...
Outcome Measures for Use in Treatment Trials of Individuals with Intellectual and Developmental Disabilities (R01- Clinical ... Outcome Measures for Use in Treatment Trials of Individuals with Intellectual and Developmental Disabilities (R01 Clinical ... Potential applicants may also be interested in the FOA "Preclinical Research on Model Organisms to Predict Treatment Outcomes ... Potential applicants may also be interested in the FOA "Preclinical Research on Model Organisms to Predict Treatment Outcomes ...
... Authors. Paul L Kaufman, MD. Paul L Kaufman, MD ... The clinical treatment and outcome of retinoblastoma are reviewed here. The clinical presentation, evaluation, and diagnosis of ... Clinical presentation, treatment, and outcome of trilateral retinoblastoma. Cancer 1991; 67:710. ... Delay in diagnosis of retinoblastoma: risk factors and treatment outcome. Br J Ophthalmol 1999; 83:1320. ...
Treatment outcome in orthognathic surgery - A prospective comparison of accuracy in computer assisted two and three-dimensional ... Conclusions: The present study indicates an equal high accuracy in predicting facial outcome for both studied techniques. ...
A test for specific genetic mutations successfully informed blood-thinner treatment selection following stent placement to open ... Genetic test may improve post-stent treatment, outcome. American Heart Association. Journal. Circulation: Genomic and Precision ... genetic-test-may-improve-post-stent-treatment-outcome?preview=. 51e2ee42ac1919de44c3c5f74ca06b16 Related Journal Article. http ... "Using an algorithm based on genetic testing to guide treatment is sustainable and associated with better clinical outcomes in a ...
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... Iuliana Toma-Dasu1 and Alexandru Dasu2 ... Iuliana Toma-Dasu and Alexandru Dasu, "Modelling Tumour Oxygenation, Reoxygenation and Implications on Treatment Outcome," ...
Proper selection of patients for aggressive salvage treatment and individualization of treatment are important in managing ... Treatment outcome for synchronous locoregional failures of nasopharyngeal carcinoma Head Neck. 2003 Jul;25(7):585-94. doi: ... Background: To review the outcome and evaluate the prognostic factors in the treatment of synchronous locoregional failures of ... Conclusions: Proper selection of patients for aggressive salvage treatment and individualization of treatment are important in ...
Does a referral to a pain treatment or spine center affect the functional outcome of patients with work-related chronic low ... Objective To evaluate return-to-work outcomes in patients with chronic, work-related low back pain referred to pain treatment ... Treatment of this condition has been approached through a number of multidisciplinary treatment programs. The level of success ... NPTC/SC indicates no PTC SC-not referred to pain treatment center/spine center; YPTC/SC, yes PTC/SC-referred to pain treatment ...
... the likely outcome of the disease) varies widely in patients with MF. Each patients prognostic risk factors are evaluated ... It is important to know that outcome data can show how groups of people with MF responded to treatment, but data cannot always ... The prognosis (likely outcome of a disease) varies widely in patients with myelofibrosis (MF). Each patients prognostic risk ...
Measuring the response to treatment with blood and bone marrow testing is a very important part of treatment for people with ... A treatment response is an improvement related to the patients treatment. Monitoring treatment response is one of the key ... For patients with CML, adhering to treatment is associated with the probability of achieving and improving long-term outcomes, ... Treatment Response Milestones. People with CML respond to treatment in different ways. These are general guidelines for CML ...
The National Association of Addiction Treatment Providers (NAATP) announced the addiction industrys new study to measure ... following outcomes from baseline to discharge and at five time points for one year after discharge from treatment. Outcome ... highly regarded treatment programs that represent a broad sampling of addiction treatment patients. The treatment center ... The study will track patient outcomes from multiple residential and outpatient addiction treatment programs. Conducted by NAATP ...
... dual antiplatelet therapy with aspirin and an ADP receptor inhibitor such as clopidogrel is the standard antiplatelet treatment ... Following Angioplasty, Personalized Antiplatelet Treatment Improves Outcome. by Kathy Jones on August 31, 2012 at 9:35 PM Heart ... "Providing individualized treatment based on the results of MEA instead of using novel antiplatelet drugs in each patient would ... Personalized antiplatelet treatment involves choosing a therapy based on the results of platelet function testing, a ...
The two most popular residential treatment settings for substance abuse recovery are therapeutic communities (TCs) and Oxford ... Social Climate in Treatment Centers Predicts Outcome. Social Climate in Treatment Centers Predicts Outcome November 16, 2011 • ... a factor that directly influences treatment outcome.. Reference:. Harvey, Ronald, and Leonard A. Jason. "Contrasting Social ... The two most popular residential treatment settings for substance abuse recovery are therapeutic communities (TCs) and Oxford ...
Treatment Surgical Therapy. Secondary intention healing. For selected defects within the cheek, secondary intention healing may ... Long-term outcome of the cheek advancement flap, a report of 41 cases. J Plast Surg Hand Surg. 2016 May 31. 1-5. [Medline]. ... Long-term outcome of the cheek advancement flap, a report of 41 cases. J Plast Surg Hand Surg. 2016 Dec. 50 (6):354-358. [ ... Cheek Reconstruction Treatment & Management. Updated: Mar 28, 2019 * Author: Jodi Stengem Markus, MD; Chief Editor: Dirk M ...
Troidle, L., & Finkelstein, F. (2006, April 6). Treatment and outcome of CPD-associated peritonitis. Annals of Clinical ... The outcome is different based on organism with gram-negative and fungal episodes having a worse outcome than gram-positive ... The treatment of CPD associated peritonitis is rather standardized with current recommendations by the International Society of ... It is important that we improve our understanding of factors responsible for the development and outcome of CPD-associated ...
Treatment Outcome of Vascular Depression. The safety and scientific validity of this study is the responsibility of the study ... This 12-week study will evaluate the effectiveness of sertraline (Zoloft®) for treatment of depression associated with small ... Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information ... Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information ...
... Kátia B. Barbosa Pagnano, Gustavo de Carvalho ... R. H. Jácomo, R. A. M. Melo, F. R. Souto et al., "Clinical features and outcomes of 134 Brazilians with acute promyelocytic ... M. A. Sanz, P. Montesinos, E. Vellenga et al., "Risk-adapted treatment of acute promyelocytic leukemia with all-trans retinoic ... acid and anthracycline monochemotherapy: long-term outcome of the LPA 99 multicenter study by the PETHEMA Group," Blood, vol. ...
The treatment for ringworm depends on its location on the body and how serious the infection is. Some forms of ringworm can be ... treated with non-prescription ("over-the-counter") medications, but other forms of ringworm need treatment with prescription ...
Information about the impact of HIV treatment on viral load, the immune system, other health conditions, mortality and quality ... as long as they get the right medical treatment and care. ...
10 Abstracts with Significant Treatment Outcome Research. Filter by Study Type. Animal Study. ... 6 Pharmacological Actions Researched for Significant Treatment Outcome Name. AC. CK. Focus. ... Additional Keywords : Activated Charcoal, Chronic Obstructive Pulmonary Disease, Iodine, Significant Treatment Outcome ... Cannabidiol treatment significantly reduces the incidence of diabetes in NOD mice.Feb 28, 2006. ...
An increasing number of calcium oxalate stone events worsens treatment outcome.. Parks JH1, Coe FL. ... Before treatment, number of stone events rises with time of observation, and rate of stone event occurrence is constant or ... During treatment, relapse is correlated with number of pretreatment stones. Life table analysis showed increasing relapse for ... Even though number of stones seems controlled by the interval of observation before treatment, more stones predict higher ...
The optimal treatment strategy for gastrointestinal graft-versus-host disease (GI-GVHD) after allogeneic hematopoietic cell ... The survival outcomes were significantly inferior in patients who did not respond to the first-line treatment (1-year overall ... Outcome of gastrointestinal graft-versus-host disease according to the treatment response. ... MacMillan ML, DeFor TE, Weisdorf DJ (2010) The best endpoint for acute GVHD treatment trials. Blood 115:5412-5417CrossRefGoogle ...
Treatment for a first episode of psychosis may be more likely to fail if a patient uses cannabis, suggests a new study that ... cannabis use within a month of their first treatment visit and tracked any subsequent treatment and outcomes for the following ... Cannabis use linked to worse treatment outcomes for psychosis patients. Written by Honor Whiteman on March 4, 2016 ... Patients experiencing a first episode of psychosis may endure worse treatment outcomes if they use cannabis, say researchers, ...
The reliability of Form 90: an instrument for assessing alcohol treatment outcome.. Tonigan JS1, Miller WR, Brown JM. ... and within-site reliability of the structured interview used to assess alcohol treatment outcomes, the Form 90. Evaluation of ... Clients for this study were most often presenting for alcohol treatment at the nine sites and were selected to be ... Form 90 appears to be a reliable instrument for alcohol treatment assessment research when interviewers have received careful ...
... after treatment completion and at 15-months follow-up ( n= 48), in a trial... ... The aim of the present study was to investigate predictors of treatment outcome for Post-traumatic Stress Disorder (PTSD) ... post-traumatic stress disorder predictors treatment outcome This is a preview of subscription content, log in to check access. ... Taylor S (2003) Outcome predictors for three PTSD treatments: exposure therapy, EMDR, and relaxation therapy. J Cogn Psychot: ...
... No Electronic Version ... No significant differences in treatment outcome and deaths were found between the 2 groups. Due to the low frequency of multi- ... In this retrospective study, the drug resistance pattern and outcome of treatment with DOTS category I [‎CAT I]‎ regimen was ... 2012)‎. Drug resistance pattern and outcome of treatment in recurrent episodes of tuberculosis. EMHJ - Eastern Mediterranean ...
Outcome and Treatment of Complex Sleep Apnea. The safety and scientific validity of this study is the responsibility of the ... Primary Outcome Measures : *Resolution of sleep apnea [ Time Frame: 24 weeks ]. As measured by the apnea-hyponea index ... Secondary Outcome Measures : *Quality of life [ Time Frame: 24 weeks ]. As measured by Epworth Sleepiness Scale and Sleep Apnea ... If the treatment is not working well at 12 weeks the participant/patients have the option of switching to the alternate ...
Metabolic outcome of GH treatment in prepubertal short children with and without classical GH deficiency ... Few studies have evaluated the metabolic outcomes of growth hormone (GH) treatment in idiopathic short stature (ISS). Moreover ... Individualized GH dose reduces the range of metabolic outcomes, and metabolic outcomes are similar in children with ISS and GHD ... after 2 years of individualized GH treatment in comparison with standard GH dose treatment. Similar metabolic changes were seen ...
Outcomes of Longer-Term Psychoanalytic Treatment. Marianne Leuzinger-Bohleber, Mary Target. ISBN: 978-0-470-06556-3 October ... Part I - Long Term Treatment in The Context of contemporary Discussions.. Part II - Long-term Psychoanalytic Therapies, German ... there is a worldwide debate as to the most appropriate ways in which to carry out research into psychopathology and treatment, ...
... Joseph J. Doyle Jr.. NBER Working Paper No. ... Published: Doyle Jr., Joseph J. "Health Insurance, Treatment, and Outcomes: Using Auto Accidents as Health Shocks." Review of ... Previous studies find that the uninsured receive less health care than the insured, yet differences in health outcomes have ...
  • Using an algorithm based on genetic testing to guide treatment is sustainable and associated with better clinical outcomes in a real-world clinical practice, although it is difficult to consistently maintain," said Craig R. Lee, Pharm.D., Ph.D., F.A.H.A., associate professor of pharmacy at the University of North Carolina at Chapel Hill Eshelman School of Pharmacy. (eurekalert.org)
  • In the MADONNA study (Multiple electrode Aggregometry in patients receiving Dual antiplatelet therapy tO guide treatmeNt with Novel platelet Antagonists), Austrian investigators led by Dr Jolanta Siller-Matula from the Medical University of Vienna and Professor G nter Christ from Kaiser Franz Josef Hospital in Vienna, investigated whether individualized treatment with platelet inhibitors according to the results of whole blood aggregometry improves clinical outcomes in patients undergoing percutaneous coronary intervention. (medindia.net)
  • Overall, they believe the findings suggest that cannabis use might be linked to worse clinical outcomes for patients with psychosis, partly mediated by the failure of antipsychotic treatment. (medicalnewstoday.com)
  • Taken together, these findings highlight the importance of ascertaining cannabis use in people receiving care for psychotic disorders and prompt further study to investigate the mechanisms underlying poor clinical outcomes in people who use cannabis and strategies to reduce associated harms. (medicalnewstoday.com)
  • Our study was designed to assess the effectiveness of frenotomy for ankyloglossia as it relates to clinical outcomes as noted in the paper and. (aappublications.org)
  • No statistically significant difference was observed when comparing the clinical outcomes of one treatment over another. (scielo.br)
  • Treatment failure, death, and LTFU were considered unfavorable treatment outcomes. (dovepress.com)
  • Tailoring interventions requires systematic investigation of neurobiological indicators that interfere with or promote favorable treatment responsivity. (clinicaltrials.gov)
  • To evaluate the effects of psychological interventions on pain-related outcomes, Kerns and his team gathered data from 22 randomized trials published between 1982 and 2003. (emaxhealth.com)
  • Our research considers clinical interventions and outcomes, patient and family experiences, and the organization of health care systems. (gc.ca)
  • Recruiting participants from 14 treatment centres across Canada, CIMDRN is collecting and analysing data on interventions and outcomes at the individual patient/family, clinic and health systems levels. (gc.ca)
  • Dr. Pranesh Chakraborty is a physician at the Children's Hospital of Eastern Ontario (CHEO), Director of Newborn Screening Ontario (NSO), Medical Director of the Better Outcomes Registry and Network (BORN) Ontario, and Associate Professor in the Department of Pediatrics, Faculty of Medicine at the University of Ottawa. (gc.ca)
  • With his wife, Alison Jefferies (who has a master's in educational psychology), Cohen wrote a book ( Anticancer Living ) about six lifestyle changes that they've linked to cancer prevention and better outcomes during and post-treatment. (goop.com)
  • The purpose of our study was 2-fold: first, to evaluate the work status outcomes in patients having chronic, work-related LBP who were referred to PTC/SC and, second, to identify predictors of positive and/or negative functional outcomes in this population. (medscape.com)
  • The aim of the present study was to investigate predictors of treatment outcome for Post-traumatic Stress Disorder (PTSD) after treatment completion and at 15-months follow-up ( n = 48), in a trial of Eye Movement Desensitisation and Reprocessing (EMDR) versus Imaginal Exposure and Cognitive Restructuring (E+CR). (springer.com)
  • Overall, our results showed that it is difficult to use pre-treatment variables as a powerful and reliable tool for predicting treatment outcome, as significant predictors were found to be sample-specific and outcome measure-specific. (springer.com)
  • Ford JD, Kidd P (1998) Early childhood trauma and disorders of extreme stress as predictors of treatment outcome with chronic posttraumatic stress disorder. (springer.com)
  • Background: Understanding trends in patient profiles and identifying predictors for adverse outcomes are key to improving the effectiveness of HIV care and treatment programs. (mendeley.com)
  • To determine predictors of outcome after percutaneous coronary intervention (PCI) in patients with cardiogenic shock complicating acute myocardial infarction. (bmj.com)
  • Therefore, the study was aimed at determining the unfavorable treatment outcome and its predictors among patients with multidrug-resistant tuberculosis in Southern Ethiopia MDR-TB treatment centers. (dovepress.com)
  • Then, a Cox regression analysis was used to identify predictors of unfavorable treatment outcome. (dovepress.com)
  • 95% CI = 1.55, 5.38) were predictors for unfavorable treatment outcome. (dovepress.com)
  • The results of a large, international systematic review published in the journal PLOS Medicine show that tuberculosis treatment is successful in children with multidrug-resistant tuberculosis (MDR-TB). (news-medical.net)
  • Among patients during 2017 who were alive at diagnosis, 89.8% had completed TB treatment successfully within one year. (cdc.gov)
  • The prognosis (likely outcome of a disease) varies widely in patients with myelofibrosis (MF). (lls.org)
  • Researchers have discovered mutations in a particular gene that affects the treatment prognosis for some patients with acute myeloid leukemia (AML), an aggressive blood cancer that kills 9,000 Americans annually. (nih.gov)
  • The diagnosis, treatment, and prognosis for the common types of GSDs are reviewed. (iospress.com)
  • Study of treatment for patients with cancer of the eye - retinoblastoma https://clinicaltrials.gov/ct2/show/results/NCT00186888 (Accessed on January 06, 2015). (uptodate.com)
  • Protocol for the study and treatment of participants with intraocular retinoblastoma https://clinicaltrials.gov/ct2/show/NCT01783535 (Accessed on January 06, 2015). (uptodate.com)
  • Conclusions: The present study indicates an equal high accuracy in predicting facial outcome for both studied techniques. (gu.se)
  • In this study, results showed that genetic testing for CYP2C19 mutations could be used to guide blood-thinner treatment after stent placement. (eurekalert.org)
  • The National Association of Addiction Treatment Providers (NAATP) announced the addiction industry's new study to measure the efficacy of addiction treatment consisting of comprehensive national data. (prweb.com)
  • The study will track patient outcomes from multiple residential and outpatient addiction treatment programs. (prweb.com)
  • Study objectives include compilation of the outcome data for peer reviewed journal publication and creation of a replication protocol that will be made available for NAATP member providers to use in their treatment centers. (prweb.com)
  • The industry lacks this information and this study is seminal in terms of its outcomes measures, cross-program data and scientific rigor. (prweb.com)
  • The study, which includes strong fidelity protocols, reviewed by and Institutional Review Board (IRB), will be driven by OMNI Institute researcher Holen Hirsh, Ph.D. and managed by NAATP Outcomes & Surveys Manager, Jessica Swan, NCACII, CACIII. (prweb.com)
  • Harvey believes this study shows that the smaller, self-run settings provide a more fertile environment for social control, a factor that directly influences treatment outcome. (goodtherapy.org)
  • In an attempt to determine how the Community Reinforcement Approach (CRA) to treatment worked compared to the CRA plus a voucher system, the researchers conducted a study on 64 individuals who met the criteria for cocaine addiction. (goodtherapy.org)
  • This 12-week study will evaluate the effectiveness of sertraline (Zoloft®) for treatment of depression associated with small vascular lesions in the brain (vascular depression). (clinicaltrials.gov)
  • This study will be the first clinical trial to simultaneously test the effects of specific brain and psychological factors on course of response, remission rate, and other measures of health outcomes in people with LLD. (clinicaltrials.gov)
  • Risk-adapted treatment of acute promyelocytic leukemia with all-trans retinoic acid and anthracycline monochemotherapy: long-term outcome of the LPA 99 multicenter study by the PETHEMA Group," Blood , vol. 112, no. 8, pp. 3130-3134, 2008. (hindawi.com)
  • Clients for this study were most often presenting for alcohol treatment at the nine sites and were selected to be representative of the larger Project MATCH sample. (nih.gov)
  • In this retrospective study, the drug resistance pattern and outcome of treatment with DOTS category I [‎CAT I]‎ regimen was compared in 63 recurrent cases and 872 new cases of pulmonary tuberculosis from April 2003 to January 2008 at the National Research Institute of Tuberculosis and Lung Disease in Tehran, Islamic Republic of Iran. (who.int)
  • Following treatment, patients will be brought back for a second sleep study to be assessed on CPAP. (clinicaltrials.gov)
  • The primary objective of the presently proposed study is to examine whether the levels of physiological outcome variables (e.g., immune responses, cortisol, blood pressure) improve in response to psychotherapy. (nova.edu)
  • Drug-Abuse Treatment Outcomes Study (DATOS) is a prospective study designed to determine the outcomes of adult drug abuse treatment delivered in typical, stable, community-based programs and to provide comprehensive information on continuing and new questions about the effectiveness of drug abuse treatment for adults currently available in a variety of publicly funded and private programs. (umich.edu)
  • The study examined the role of treatment outcomes and program type, client characteristics (including dependence, treatment history, and physical and mental health comorbidities), treatment received (e.g., length and intensity of services provided), therapeutic approaches, provision of aftercare, and research on the components of effective treatment, including factors that engage and retain clients in programs. (umich.edu)
  • The findings of the study found important perspectives on the role of inhalation devices in COPD treatment. (emaxhealth.com)
  • This study also found treatment changes were typically triggered by symptoms and exacerbations rather than poor device technique. (emaxhealth.com)
  • This study aims to investigate the outcome of pediatric DTC and factors predicting the response to therapy in pediatric DTC managed according to adult guidelines. (degruyter.com)
  • This study represents an attempt to assess the effectiveness of court-mandated treatment for wife assault. (ingentaconnect.com)
  • Commenting on the study, Dr Nathan Cherny from the Shaare Zedek Medical Center in Jerusalem, said the study demonstrates that even when patients do not have to pay -- for example, when they are participating in a clinical trial -- a significant number of them enter treatment with some degree of financial burden. (eurekalert.org)
  • These studies were case series and therefore did not meet study design criteria and measured tongue mobility, which we considered an intermediate outcome. (aappublications.org)
  • This pilot study involves providing drug addicts with cognitive behavioral therapy (CBT), a treatment considered to be one of the most effective in reducing substance-abuse, to identify ways in which the brain works that may predict and explain treatment effects. (clinicaltrials.gov)
  • This study will evaluate the effectiveness of a brief cognitive behavioral therapy, administered by community agencies, for the treatment of patients with Post Traumatic Stress Disorder (P. (bioportfolio.com)
  • This study will determine the effectiveness of immediate treatment with prolonged exposure therapy (PE) versus delaying treatment with PE in altering neuroendocrine-related symptoms of pos. (bioportfolio.com)
  • Placebo Effects Across Self-Report, Clinician Rating, and Objective Performance Tasks Among Women With Post-Traumatic Stress Disorder: Investigation of Placebo Response in a Pharmacological Treatment Study of Post-Traumatic Stress Disorder. (bioportfolio.com)
  • Conservative surgery and radiation therapy (RT) are known to provide excellent local control, but the relationship of technique to functional outcome requires further study. (biomedsearch.com)
  • In fact, Caron, an active member of the National Association for Addiction Treatment Providers ( NAATP ) along with up to 13 other nationally recognized treatment providers, will participate in a pilot study by the NAATP starting this year. (caron.org)
  • The purpose of this study was to compare the occurrence of tuberculosis (TB) and the outcome of treatment between TB patients living in urban and rural areas. (cambridge.org)
  • The study was used to inform the World Health Organization guidelines on treatment of MDR-TB in children. (news-medical.net)
  • The study, which involved a collaborative group of international researchers, included a systematic review and patient data meta-analysis on the clinical characteristics and treatment outcomes of 975 children from 18 countries. (news-medical.net)
  • In the literature there are a lot of factors in the treatment for locally advanced cervical cancer, in that study we searched the prognostic factors for treatment. (scirp.org)
  • This study shows that prognostic factors, which are tumor size, age, presence of residual tumor, number of chemotherapy treatments, are important for treatment options. (scirp.org)
  • In this present study, our gynecology oncology clinic evaluate all the patients every week for treatment options. (scirp.org)
  • Advanced imaging techniques could allow clinicians the ability to determine as early as 9 days into sarcoma treatment whether the therapy will be effective in a given patient, according to a new University of Michigan study. (cancernetwork.com)
  • Study author Vadim Koshkin, MD, who is with the University of Michigan Health System, Ann Arbor, Mich., said if a patient had a PET scan at day 9 that suggested the cancer was progressing despite the treatment. (cancernetwork.com)
  • A cohort study was conducted alongside this trial following women who received treatment of their preference. (uva.nl)
  • NEW YORK (GenomeWeb) - BRCA2 mutations are associated with poorer treatment responses and outcomes among men with aggressive prostate cancer, according to a new study. (genomeweb.com)
  • We report trends in manifestations, treatment, and out- comes of 355 children with culture-confi rmed melioidosis of an invasive bacterial infection surveillance study. (cdc.gov)
  • Repeat searches of the databases were con- drugs used for empirical treatment of sepsis contrib- ducted at the end of the study (Appendix Figure 1, ute to high mortality rates ( 2 - 4 ). (cdc.gov)
  • Resultsfrom the prostate cancer outcomes study. (calstatela.edu)
  • Thus far, only one published study has found a correlation of gene expression of macrophage-associated genes with favorable outcome. (haematologica.org)
  • 12 However, in two earlier studies, the authors of this study reported that the same genes, namely LYZ and STAT1 , were linked to unfavorable outcome, findings that the authors also validated by immunohistochemistry. (haematologica.org)
  • This study aims to review the survival and morbidity in patients treated for endometrial cancer, at a single centre and analyses the effects of co-morbidity on these outcomes. (spandidos-publications.com)
  • In 2018, Monte Nido began a comprehensive research study, approved by an Institutional Review Board, in order to assess treatment outcomes in our Residential, Partial Hospitalization Program (PHP) and Intensive Outpatient Program (IOP) levels of care. (montenido.com)
  • We have been evaluating the short- and long-term benefits of our services for decades, and have previously published the only peer-reviewed, decade-long, post-graduate outcome study on residential eating disorder clients. (montenido.com)
  • TUESDAY, Jan. 20, 2015 (HealthDay News) -- Over the past two decades, the health of children born with the help of fertility treatments has improved substantially, according to a new study. (mentalhelp.net)
  • Over the study period, the researchers found that fewer singleton babies conceived through fertility treatments were born with a low birth weight of about 5.5 pounds or very low birth weight (about 3 pounds). (mentalhelp.net)
  • A second study, "Racial Disparities in Diagnosis and Treatment Options," suggested that age at colorectal cancer diagnosis, location of tumor within the colon and survival from colorectal cancer varies significantly among race. (scienceblog.com)
  • These findings if validated by a larger study, can potentially affect medical guidelines regarding screening and treatment of colorectal cancer," said researcher Chinar Mehta, M.D. (scienceblog.com)
  • Since minorities and women are often under‐represented in population‐based studies, a third CRC study unveiled today, "Gender Differences in the Colonoscopy Outcomes in Elderly African Americans," found that elderly African American females undergo colonoscopy more often than males and have a higher right‐sided incidence of advanced adenomas. (scienceblog.com)
  • A retrospective follow-up study was conducted in Southern Ethiopia MDR-TB treatment initiating centers. (dovepress.com)
  • The primary outcomes evaluated in the study were relapse and 5-year relapse-free survival. (aidsmap.com)
  • There are a wide range of outcomes to study including mortality, morbidity, functional status, mental well-being, and other aspects of health-related quality of life. (wikipedia.org)
  • A significant subset of patients with LLD, particularly those with vascular depression, have abnormalities in certain parts of the brain that are evident on MRI scans and may be associated with poor acute and long-term response to antidepressant treatment. (clinicaltrials.gov)
  • Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines," Haematologica , vol. 92, no. 10, pp. 1431-1432, 2007. (hindawi.com)
  • Treatment for acute. (bmj.com)
  • Objective To compare, in young active adults with an acute anterior cruciate ligament (ACL) tear, the mid-term (five year) patient reported and radiographic outcomes between those treated with rehabilitation plus early ACL reconstruction and those treated with rehabilitation and optional delayed ACL reconstruction. (bmj.com)
  • These results should encourage clinicians and young active adult patients to consider rehabilitation as a primary treatment option after an acute ACL tear. (bmj.com)
  • 2 3 Acute anterior cruciate ligament injury may lead to unsatisfactory knee function, decreased activity, and poor knee related quality of life, and many patients with a torn anterior cruciate ligament develop osteoarthritis of the knee irrespective of treatment. (bmj.com)
  • 1 4 5 6 In young active adults with an acute anterior cruciate ligament tear in a previously uninjured knee, we found no difference in the patient reported outcomes after two years in a randomised controlled trial comparing two treatment strategies: structured rehabilitation plus early anterior cruciate ligament reconstruction or the same structured rehabilitation with the option of having a later reconstruction if needed. (bmj.com)
  • Cases of acute prostatitis are usually completely resolved by appropriate antibiotic treatment. (health24.com)
  • 2. add to the cost-effectiveness on treatment options for workers in the sub acute phase of low back pain. (tudelft.nl)
  • In multivariate analyses available to a subset of the entry cohort, a longer tenure in treatment was a robust predictor of posttreatment outcomes. (rand.org)
  • Fifty men who completed a 16-week treatment program had a 4% recidivism rate for a posttreatment period of up to 3 years. (ingentaconnect.com)
  • Identify baseline ECF and emotion regulatory functions and their neural substrates that predict treatment variability in the form of: (a) program responsivity (e.g., treatment engagement, motivation, social competences) and (b) posttreatment outcomes (e.g., substance use frequency, days of continuous abstinence). (clinicaltrials.gov)
  • Conclusion Referral to a PTC/SC did not yield improved functional outcomes in this cohort. (medscape.com)
  • First-week Dimensions of Change Instrument (DCI) assessments from a cohort of 519 adults entering six therapeutic communities (TCs) were used to predict treatment retention and outcomes. (rand.org)
  • For the entire cohort, the unfavorable treatment outcome was 23.68% (19.29, 28.09). (dovepress.com)
  • People with HIV treated for aggressive forms of non-Hodgkin lymphoma or Burkitt lymphoma appear no more likely to suffer a relapse after treatment than HIV-negative people treated for the same conditions, according to findings of an analysis of the German HIV Lymphoma Cohort published this month in Haematologica , the journal of the European Hematology Association. (aidsmap.com)
  • The treatment cohort consisted of 387 people, of which 254 achieved remission after the first course of treatment, 21 after further chemotherapy, 22 achieved partial remission (reduction in lymphoma mass of at least 50% and no further spread) and 15 were still receiving chemotherapy at the time of analysis. (aidsmap.com)
  • These centers provide various modalities of treatment, including spinal injections, pain medication, and psychological and behavioral therapy. (medscape.com)
  • As both behavioral therapy and child psychoanalytic psychotherapy target self-regulation through the related constructs of emotion regulation and "hot" executive functions ( 9 ), the both modalities' successful outcomes may show similar underlying neural changes. (frontiersin.org)
  • The findings were presented by Dr Jolanta Siller-Matula from Medical U...Standard antiplatelet treatment in patients undergoing percutaneous co. (bio-medicine.org)
  • Patterns of drug resistance in recurrent cases of tuberculosis may be different than in those without a history of treatment. (who.int)
  • 1 The treatment outcome of MDR-TB could be cured, completed, treatment failure, lost to follow-up (LTFU), died, and extensively drug-resistant tuberculosis (XDR-TB). (dovepress.com)
  • What is behind programmatic treatment outcome definitions for tuberculosis? (ersjournals.com)
  • Irrespective to outcome measures and assessment points it was found that four variables were able to predict significantly treatment outcome. (springer.com)
  • Propensity score-matched analysis of surgical NEC treatment found that peritoneal drainage followed by laparotomy was associated with decreased mortality compared with peritoneal drainage alone but at significantly increased costs. (aappublications.org)
  • LUGANO-COPENHAGEN, Oct. 10, 2016 - Financial difficulties can significantly impact a cancer patient's quality of life during treatment and may even increase their risk of death, according to the results of a pooled analysis presented at the ESMO 2016 Congress in Copenhagen. (eurekalert.org)
  • 1995 a ) found, for example, that the methodological quality of research outcome studies has improved significantly in the past 20 years, much of this due to selection of assessment instruments with known psychometric properties and the appropriate use of multivariate techniques. (nih.gov)
  • Active treatment was associated with a significantly improved fetal outcome, due in part to a reduced number of mid-pregnancy abortions. (biomedsearch.com)
  • For a drug to acquire Food and Drug Administration approval, it must significantly outperform placebo treatment. (bioportfolio.com)
  • Crude odds ratios showed a significantly higher level of treatment non-completion in rural areas. (cambridge.org)
  • In a multivariate analysis, potentially unfavourable outcome (17%), compared to treatment success, was significantly associated with being male, born abroad and having lived in France for less than 10 years, being in congregate settings when treatment was initiated, or having a previous history of anti-TB treatment. (eurosurveillance.org)
  • Prompt referral to an ocular oncologist and appropriate management by a multidisciplinary team are necessary to optimize visual outcome and survival. (uptodate.com)
  • Management of children with retinoblastoma is best accomplished by a multidisciplinary team, which can minimize the number of clinic visits and provide the caregivers with opportunities to discuss the full spectrum of treatment and outcomes. (uptodate.com)
  • Treatment of this condition has been approached through a number of multidisciplinary treatment programs. (medscape.com)
  • Outcomes research is a multidisciplinary field of inquiry that examines the use, quality, delivery, and financing of health care services to increase knowledge and understanding of the structure, processes, and effects of health services for individuals and populations. (wikipedia.org)
  • Of importance in this multisite trial examining the efficacy of client-treatment matching was the cross- and within-site reliability of the structured interview used to assess alcohol treatment outcomes, the Form 90. (nih.gov)
  • In those randomized to CPAP who have a persistent poor clinical response associated with an abnormal residual AHI after 24 weeks of treatment, a further 12 week trial of ASV will be undertaken to assess whether it offers any benefit. (clinicaltrials.gov)
  • June 5, 2018 -- By using PET scans to assess the efficacy of chemotherapy for esophageal cancer early in the course of treatment, clinicians can change their treatment strategy if necessary and greatly improve patient outcomes, according to a presentation at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago. (auntminnie.com)
  • PURPOSE: To systematically assess the functional outcome of patients treated with surgery and irradiation for extremity or truncal sarcomas, and to correlate this outcome with a detailed analysis of the radiation dose distribution and surgical technique. (biomedsearch.com)
  • Objective: To assess the effect of alarm treatment in children with day- and night-time wetting compared to those with night-time wetting only. (tudelft.nl)
  • While concurrently receiving treatment within the TRIP clinic, each volunteer will have their physiological activity, immune activity, psychological stress, depression, dissociation, and PTSD symptoms measured each month, for six months. (nova.edu)
  • Optimal pharmacological treatment for COPD patients reduces symptoms, reduces the frequency and severity of exacerbations, improve health status and increases exercise tolerance. (emaxhealth.com)
  • Chronic prostatitis is likely to recur despite treatment, but symptoms are milder and can be reduced by changes in lifestyle. (health24.com)
  • While treatment for ADHD should improve your child's behavior, it may not completely eliminate the symptoms of inattention, hyperactivity, and impulsivity. (healthychildren.org)
  • The theoretical discussion of these treatments and psychological factors which maintain symptoms can lead to further development of treatments and to a better understanding of schizophrenia. (researchandmarkets.com)
  • As early as 1985, Ree and Kadin suggested that macrophages in HL biopsies had a prognostic value when they found the number of peanut agglutinin-binding macrophages was correlated with the presence of B symptoms and primary treatment failure. (haematologica.org)
  • Results indicate that patients experienced clinically and statistically significant reductions in eating disorder symptoms over the course of treatment in the Residential, PHP and IOP levels of care on nearly all scales. (montenido.com)
  • While there is currently no cure for the disease, advances in treatment over the last decade have produced an arsenal of new medicines to slow disease progression, prevent relapses, and more effectively manage symptoms. (phrma.org)
  • The disappearance of signs and symptoms of a disease, usually in response to treatment. (aidsmap.com)
  • Novel biological markers that improve on primary treatment outcome prediction across all clinical stages will, therefore, be critical to advancing the field. (haematologica.org)
  • Many studies in HL have, therefore, focused on the cellular composition of the microenvironment, not only to gain more insight into the pathobiology of the disease, but also to explore whether these immune-related cells in some way contribute to outcome prediction. (haematologica.org)
  • multiple reports now support the value of enumerating tumor-associated macrophages in pretreatment biopsies for outcome prediction in classical HL ( Table 1 ). (haematologica.org)
  • Using morphomic variables, far more accurate prediction of individual outcomes and costs is possible. (umich.edu)
  • To review the outcome and evaluate the prognostic factors in the treatment of synchronous locoregional failures of nasopharyngeal carcinoma (NPC). (nih.gov)
  • On multivariate analysis, treatment by reirradiation or chemotherapy alone and rN2 disease were independent factors that predicted poor survival, whereas treatment by reirradiation or chemotherapy alone was the only independent factor that predicted further relapse or failure. (nih.gov)
  • It is important that we improve our understanding of factors responsible for the development and outcome of CPD-associated peritonitis in order for this renal replacement therapy to remain a viable option for patients with ESRD. (mendeley.com)
  • The authors say they were unable to gather enough information from the health records to determine whether the greater number of antipsychotic prescriptions among cannabis users was driven by poor treatment response, poor compliance or other factors. (medicalnewstoday.com)
  • Factors associated with treatment outcome were investigated using regression analyses with the mean change scores in three assessor and self-rated PTSD symptomatology measures, including the Clinician-Administered PTSD Scale (CAPS), the Impact of Events Scale (IES) and the PTSD Symptom Checklist (PCL) from pre- to post-treatment and pre-treatment to follow-up as the dependent variables and demographics, trauma, clinical and personality measures as independent variables. (springer.com)
  • This paper describes trends in demographic and clinical characteristics of antiretroviral therapy (ART) treatment cohorts at a large urban, referral HIV clinic and explores treatment outcomes and factors associated with attrition during 12 years of follow-up. (mendeley.com)
  • To analyze prognostic factors, and to report treatment outcome of relapsing/refractory mature B cell NHL. (lww.com)
  • This approach will enable researchers to determine what factors might be interfering with favorable treatment outcomes and how to refine or develop new treatments that work well for more people. (clinicaltrials.gov)
  • This work gives us more understanding of the potential success of treatment, the potential for certain children to receive less-intensive, less-toxic regimens, and an understanding of risk factors for poor outcomes across settings, which is important for designing future treatment regimens. (news-medical.net)
  • Concomitant chemotherapy and treatment duration were the important prognostic factors for completed response locally advanced cervical cancers. (scirp.org)
  • Factors that may contribute to survival disparities include less access to and lower use of colorectal cancer screening tests and less access to timely and high‐quality treatment. (scienceblog.com)
  • That said, as powerful as we know lifestyle factors are in preventing cancer and improving outcomes for those with cancer, we need to avoid guilt, blame, or shame about what may have caused a cancer. (goop.com)
  • The group members utilize national health services and administrative databases, as well as institutional databases, to investigate and to address factors contributing to disease outcomes and healthcare disparities. (wikipedia.org)
  • Pancreatic cancer and pancreatic disease Other gastrointestinal and hepatobiliary malignancies Vascular disease Transplant surgery and transplant psychology Investigating factors that affect surgical outcomes for diverse specialties including colorectal, cardiovascular, transplant, plastic and reconstructive, and minimally invasive surgery Boston Medical Center (BMC) in Boston, Massachusetts is a teaching hospital of Boston University School of Medicine. (wikipedia.org)
  • See also: Boston Medical Center Website SOAR researchers use national health services and administrative databases as well as prospective institutional tissue-linked databases to investigate factors contributing to disease outcomes for pancreatic cancer, hepato biliary disease, vascular disease, colorectal disease, plastic and reconstructive surgery, and transplant medicine. (wikipedia.org)
  • Each investigator in the group is working to understand how variations in very specific body structures impact and predict outcomes. (umich.edu)
  • Elderly cancer patients who are HIV-positive, particularly those with prostate and breast cancers, have worse outcomes compared to cancer patients in the same age range who do not have HIV. (news-medical.net)
  • A research team led by Dr. Timothy Ley at the Washington University School of Medicine set out to investigate how genetic changes affect treatment outcomes. (nih.gov)
  • The Cancer and Leukemia Group B trial, CALGB 80303, began about 10 years ago to investigate the efficacy of standard esophageal cancer treatment, which typically combines preoperative chemotherapy with radiation followed by surgery. (auntminnie.com)
  • The Canadian Inherited Metabolic Diseases Research Network (CIMDRN) has developed a national research program to investigate patient treatments and outcomes to help create more effective, evidence-informed health care for children with IEM. (gc.ca)
  • used immunohistochemistry to investigate a large number (n = 288) of pretreatment biopsies from patients with HL and found a significant correlation between tumor-associated macrophages and adverse treatment outcome. (haematologica.org)
  • Time from injury to initial evaluation seemed to be the major factor contributing to poor outcomes in both groups. (medscape.com)
  • In the cases we studied, mutations in the DNMT3A gene trump everything else we've found so far to predict adverse outcomes in intermediate-risk AML. (nih.gov)
  • The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. (uptodate.com)
  • GoodTherapy.org is not intended to be a substitute for professional advice, diagnosis, medical treatment, or therapy. (goodtherapy.org)
  • Using the Surveillance, Epidemiology, and End Results Medicare-linked data, the researchers evaluated 288 HIV-infected and 307,980 HIV-uninfected patients, ages 65 years or older, who were diagnosed with non-advanced colorectal, lung, prostate or breast cancer and received stage-appropriate cancer treatment during the year after their cancer diagnosis. (news-medical.net)
  • The information on Health24 is for educational purposes only, and is not intended as medical advice, diagnosis or treatment. (health24.com)
  • Once the diagnosis is confirmed, the outlook for most children who receive treatment for ADHD is encouraging. (healthychildren.org)
  • EmaxHealth is for informational purposes and should not be considered medical advice, diagnosis or treatment recommendations. (emaxhealth.com)
  • This improvement is due in part to the expansion of newborn screening allowing for earlier diagnosis and treatment. (gc.ca)
  • Objective To evaluate return-to-work outcomes in patients with chronic, work-related low back pain referred to pain treatment centers and/or spine clinics (PTCs/SCs). (medscape.com)
  • [ 8-11 ] One of the many approaches in the management of chronic LBP includes management by pain treatment centers (PTCs) and/or spine clinics (SCs). (medscape.com)
  • Specifically, he said, the CDC has set up 137 treatment centers for hemophilia, which affects only a small fraction of those with sickle cell. (medpagetoday.com)
  • One of the filmmakers is quoted as saying that treatment centers, "paint this picture that they're going to fix everything. (caron.org)
  • Each evidence-based review centers on a specific psychological assessment or treatment conducted in the context of a physical disease process or risk reduction effort. (emaxhealth.com)
  • We reviewed the records of 43 patients with synchronous locoregional failures of NPC who received salvage treatment or chemotherapy between November 1986 and January 2001. (nih.gov)
  • The 3-year relapse-free survival (RFS) rate and disease-specific survival (DSS) rate after salvage treatment or chemotherapy were 17% and 38%, respectively. (nih.gov)
  • In patients with more advanced disease, treatment by reirradiation alone or palliative chemotherapy is largely ineffective and is associated with a poor outcome. (nih.gov)
  • Unfortunately, relapsed NHL has a dismal outcome, and customary treatment is by highly toxic chemotherapy followed by hematopoietic stem cell transplantation (HSCT). (lww.com)
  • Chemotherapy is the standard treatment for patients found to have an intermediate risk profile. (nih.gov)
  • The problem is that our outcomes are still quite poor, even with an aggressive management of chemotherapy, radiation, and surgery," Goodman told AuntMinnie.com . (auntminnie.com)
  • Multiple prior studies have used different treatment regimens, but not every patient responds well to chemotherapy. (auntminnie.com)
  • This was based on previous studies from Germany that established the 35% mark as a predictive cutoff for favorable outcomes for patients with esophageal cancer receiving chemotherapy. (auntminnie.com)
  • PET scans before and after chemotherapy from a patient who responded to treatment. (auntminnie.com)
  • The primary treatment of locally advanced cervical cancer is the radical radiotherapy applied concomitantly with cisplatin based chemotherapy. (scirp.org)
  • Not only do low lymphocyte counts predict poor outcome, but patients with high lymphocyte counts also have excellent outcomes, and clinicians may be able to reduce the amount of chemotherapy these patients receive. (mdanderson.org)
  • Relapse after treatment occurs in about one in ten cases in the general population but German researchers wanted to know if people with HIV suffered higher rates of relapse and whether dose reductions or chemotherapy cycle reductions had any impact on the risk of relapse. (aidsmap.com)
  • Adjusted economic differences for various surgical treatments may exist but have not been elucidated. (aappublications.org)
  • The highest value treatment of these 3 surgical management options may best be identified by using an as-treated comparison. (aappublications.org)
  • 1 The relative importance of surgical reconstruction and rehabilitation for the short and long term outcome is debated. (bmj.com)
  • For ectopic testes and testes that have never been scrotal, a referral for surgical treatment should be made prior to the second birthday. (tudelft.nl)
  • Eleven patients underwent conservative treatment and for the remaining the treatment was surgical. (scielo.br)
  • Analytic Morphomics® enables more precise evaluation of patient risk at baseline and following surgical or medical treatment. (umich.edu)
  • Surgical Outcomes Analysis & Research, SOAR, is a research laboratory of the Department of Surgery at Boston University School of Medicine and Boston Medical Center with expertise in outcomes research. (wikipedia.org)
  • SOAR investigates surgical diseases and perioperative outcomes. (wikipedia.org)
  • SOAR members hope, as part of the surgical outcomes research community, to improve overall outcomes for patients with surgical diseases. (wikipedia.org)
  • The research team will collect a large data sample of over 1,000 patients, following outcomes from baseline to discharge and at five time points for one year after discharge from treatment. (prweb.com)
  • Main outcome measure The main outcome was the change from baseline to five years in the mean value of four of the five subscales of the knee injury and osteoarthritis outcome score (KOOS 4 ). (bmj.com)
  • Proper selection of patients for aggressive salvage treatment and individualization of treatment are important in managing patients with synchronous locoregional failures of NPC. (nih.gov)
  • A significant proportion of patients with early stage locoregional failures can still achieve long-term disease control and survival after aggressive salvage treatment using surgery with or without combined radiotherapy. (nih.gov)
  • More aggressive treatments could help those with the DNMT3A mutations live longer. (nih.gov)
  • Malnutrition was shown as another factor that affected treatment outcome and highlights the need for aggressive solutions. (news-medical.net)
  • If we know that a patient is at high risk for relapse from the beginning, then potentially we can adjust the treatment plan to a more aggressive therapy. (mdanderson.org)
  • It is an exciting time to conduct alcoholism treatment outcome evaluation. (nih.gov)
  • It is also a critical time for doing rigorous outcome evaluation. (nih.gov)
  • In many States evaluation is now legislatively mandated, with future program appropriations tied to demonstration of treatment effectiveness. (nih.gov)
  • Programs and jobs can hinge on how well an evaluation report communicates findings to audiences unfamiliar with research methodology and the multifaceted nature of alcohol treatment outcome(s). (nih.gov)
  • The purpose of this chapter is to familiarize the reader with a variety of fundamental issues that arise in the conduct of outcome evaluation in alcoholism treatment. (nih.gov)
  • The next section briefly addresses the goals of summative and formative alcohol-related outcome evaluation, highlighting the differences between individual and group-based evaluation. (nih.gov)
  • The final section outlines some practical considerations in alcohol outcome evaluation, including interviewer role and training, instrument consistency, and data entry. (nih.gov)
  • Led by Drs. Beth Potter and Pranesh Chakraborty, the network is focusing on understanding the implications of the shift in treatment goals for IEM from 'urgent care' to 'opportunity for improvement', a better understanding of variation in disease and the need for personalized care, and, critical evaluation and comparison of existing and new therapies. (gc.ca)
  • Economic Evaluation of Psychological Treatments for Schizophrenia (M. Knapp & A. Healey). (researchandmarkets.com)
  • Analytic Morphomics® enables more precise evaluation of a patient for drug dosing and measurement of treatment effectiveness. (umich.edu)
  • Following the launch of the DOTS (directly observed treatment, short-course) strategy in 1995, the World Health Organization (WHO) recommended the evaluation of treatment outcomes [ 1 , 2 ]. (ersjournals.com)
  • While historically multidrug-resistant (MDR)-TB outcome definitions were developed by the research community and adopted by programmes, we now need definitions for programmes which allow rapid evaluation and scale-up of treatment services. (ersjournals.com)
  • This research may also include the evaluation of economic impacts linked to health outcomes, such as cost effectiveness and cost utility. (wikipedia.org)
  • findings indicate the benefits of personalized approaches to prostate cancer treatment and management. (medindia.net)
  • These findings may help guide future treatment strategies for patients with AML. (nih.gov)
  • Software advances for personal computers have also spawned an audience-friendly revolution in how findings are presented, with time-to-event outcomes, hierarchical linear modeling findings, and structural equation modeling findings now presented in an understandable and graphic format. (nih.gov)
  • The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. (mdanderson.org)
  • These findings show convincingly that while there has been a considerable increase in assisted reproduction cycles over the past 20 years, this has been accompanied by a significant improvement in health outcomes for these babies, particularly for singleton babies," she said. (mentalhelp.net)
  • The Krickenbeck classification was found to predict functional outcome, and ARM patients had more problems with incontinence and obstipation, as well as inferior Quality of Life (QoL), compared with controls. (diva-portal.org)
  • Sarcoma therapy: functional outcome and relationship to treatment parameters. (biomedsearch.com)
  • The mean functional outcome score was 5.1 with a range of 0-16. (biomedsearch.com)
  • 34 patients (83%) had good or excellent functional outcomes. (biomedsearch.com)
  • CONCLUSIONS: A system for functional assessment has been developed which is easily performed and provides detailed information about patient functional outcome. (biomedsearch.com)
  • however, significant variability in treatment outcomes remains. (clinicaltrials.gov)
  • Judgements about effectiveness are complicated by the variability of outcome assessment measures. (researchandmarkets.com)
  • Analytic Morphomics® identifies bio-markers using medical imaging that provides insight into disease processes, treatment options, and outcome variability. (umich.edu)
  • A total of 254 achieved complete remission after the first course of treatment (127 with DLBCL, 91 with Burkitt lymphoma, 29 with PBL and seven with other non-classifiable B-cell lymphomas). (aidsmap.com)
  • Complete remission from lymphoma was achieved if there was no visible evidence of lymphoma for at least three months after the completion of treatment. (aidsmap.com)
  • To evaluate if individualized GH treatment reduced the variance of the metabolic measures as shown for growth response and to compare changes in metabolic variables in children with ISS and GHD. (ingentaconnect.com)
  • This thesis aims to evaluate (1) the long-term outcome in adulthood of ARMs in relation to the modern Krickenbeck classification, and (2) scope for treating FI with transanal injection with dextranomer in non-animal stabilised hyaluronic acid (NASHA/Dx), in patients both with and without ARMs. (diva-portal.org)
  • and a section that introduces the concept of meaningful changes in drinking behavior and then offers specific recommendations for clinicians and researchers on how to evaluate the magnitude of behavior changes associated with treatment. (nih.gov)
  • This paper uses the abrupt changes in health insurance coverage at age 65 arising from the Medicare program eligibility rules to evaluate the impact of insurance status on treatment intensity and health outcomes. (rand.org)
  • To evaluate local control, survival, radiation side effects and treatment outcome in locally advanced cervical cancer patients. (scirp.org)
  • There is a need to evaluate care with the goal of achieving the "triple aim" of improved clinical health outcomes, improved patient and family experiences, and manageable health system impacts. (gc.ca)
  • To evaluate the correlation between structural changes in burst fractures of thoracic and lumbar spine with clinical outcome of the treatment. (scielo.br)
  • No significant differences in treatment outcome and deaths were found between the 2 groups. (who.int)
  • Previous studies find that the uninsured receive less health care than the insured, yet differences in health outcomes have rarely been studied. (nber.org)
  • In these studies we found no differences in subsequent pregnancy rates or pregnancy outcomes. (uva.nl)
  • Racial differences ininitial treatment for clinically localized prostate cancer. (calstatela.edu)
  • Summary of Background Data Return-to-work outcomes in cases of work-related chronic low back pain after referral to PTCs and/or SCs have not been previously studied. (medscape.com)
  • To date, there have been no reported studies evaluating outcomes in patients with work-related chronic LBP after referral to PTC/SC. (medscape.com)
  • The results of the proposed project may provide increased understanding of the physiological variables that respond to successful trauma treatment, relationships between physiological and psychological variables associated with trauma exposure, and relationships between the physiological variables and chronic pain and/or chronic health conditions. (nova.edu)
  • Treatment for ADHD uses the same principles that are used to treat other chronic conditions like asthma or diabetes. (healthychildren.org)
  • The comparison of treatment data against normal controls is not the same as comparing treatment versus no treatment in similar populations, which is the focus of comparative effectiveness research. (aappublications.org)
  • This book brings together some of the latest evidence for the benefits and effectiveness of these treatments over a range of problems which include cognitive deficits, delusions and hallucinations, family stress and burden, and social functioning. (researchandmarkets.com)
  • By showing the clinical effectiveness and economic costs/benefits of these treatments, and suggesting how these can be better measured, this volume makes a powerful contribution to the growth and practice of the psychological treatment of schizophrenia. (researchandmarkets.com)
  • In addition to guiding treatment planning, this data allows leadership to track program effectiveness and identify areas for program development. (montenido.com)
  • We, as an addiction treatment industry, know that treatment works and saves lives but we must demonstrate this and gain new information. (prweb.com)
  • The pilot participants are all successful, highly regarded treatment programs that represent a broad sampling of addiction treatment patients. (prweb.com)
  • The paper, 'Post-Treatment Recovery Support - The future of long-term recovery from addiction', recaps MAP's initial five years of outcomes data collection and points to the future of addiction treatment. (prweb.com)
  • Due to its advanced algorithm-driven technologies and population health management platform, MAP has quickly established itself as a pioneer in the behavioral health space utilizing telehealth resources to improve the outcomes of people treated for addiction and substance use disorder. (prweb.com)
  • The data demonstrated by MAP has sparked the attention of major health insurance payers motivated to contain the rising costs of increased recidivism in addiction treatment and who have begun to express interest in reimbursing providers for extending the care continuum. (prweb.com)
  • In addition to demonstrating game-changing outcomes data, the authors have set the stage for the future of addiction treatment and long-term, sustainable recovery. (prweb.com)
  • From its position on the forefront of the behavioral health field, we can expect to see future white papers that expound on the importance of collecting and demonstrating outcomes data to addiction treatment providers, health insurance payers and healthcare consumers. (prweb.com)
  • We also agree that the addiction treatment industry should have standards for measuring success rates - with an investment in more significant outcome data. (caron.org)
  • Although Caron's treatment and the My First Year program are deeply rooted in the 12-Steps, Caron doesn't view the 12-steps as an "all or nothing" aspect of addiction treatment. (caron.org)
  • For those seeking addiction treatment for themselves or a loved one, the MentalHelp.net helpline is a private and convenient solution. (mentalhelp.net)
  • A treatment response is an improvement related to the patient's treatment. (lls.org)
  • This includes a patient's legal right to treatment within 18 weeks of referral ( https://www.gov.uk/government/publications/the-nhs-constitution-for-england/the-nhs-constitution-for-england ). (nature.com)
  • It results from either primary infection or may develop in the course of a patient's treatment. (dovepress.com)
  • A dual antiplatelet therapy with aspirin and an ADP receptor inhibitor such as clopidogrel is the standard antiplatelet treatment in patients undergoing angioplasty. (medindia.net)
  • Cocaine accounted for 46.9% of all treatment admissions for drug dependence in Spain, and 62.5% of the total if we consider only those cases treated for the first time in the person's life," said researchers from Spain. (goodtherapy.org)
  • Patients experiencing a first episode of psychosis may endure worse treatment outcomes if they use cannabis, say researchers, after finding that such patients are 50% more likely to be admitted to the hospital after initial treatment than non-users of cannabis. (medicalnewstoday.com)
  • The researchers assessed patients' cannabis use within a month of their first treatment visit and tracked any subsequent treatment and outcomes for the following 5 years. (medicalnewstoday.com)
  • What is more, the researchers found that cannabis users were more likely to be prescribed a drug called clozapine - commonly used for hard-to-treat schizophrenia - and had a higher number of prescriptions for a range of other antipsychotic medications in the 5 years after first treatment, compared with non-users. (medicalnewstoday.com)
  • In an article published in BMC Medicine in May 2015, researchers Sedelaar and Schalken from Radboud University Medical Center, Nijmegen, The Netherlands, suggested that using genetic and molecular classifiers to personalize treatment could have positive outcome and better survival chances for patients with castration-resistant prostate cancer. (medindia.net)
  • Researchers Sedelaar and Schalken conclude that genomic classifiers could possibly be used with positive outcomes for a personalized approach to cancer treatment and care. (medindia.net)
  • Perrone said the researchers had expected to find an impact on quality of life from financial hardship, but were surprised to see that worsening financial problems during treatment was associated with a higher risk of death over the course of treatment. (eurekalert.org)
  • Researchers are working to find out what characteristics predict treatment response. (clinicaltrials.gov)
  • As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
  • The researchers reviewed the health outcomes of more than 62,000 single babies and nearly 30,000 twins born with the help of assisted reproduction. (mentalhelp.net)
  • In the DECISION trial, researchers randomly assigned 417 treatment-naive patients with radioactive iodine-refractory locally advanced or metastatic DTC that had progressed within the past 14 months to sorafenib 400 mg twice daily or placebo. (healio.com)
  • Researchers continue to focus on meeting the unmet needs of patients with the progressive form of MS, who presently lack available treatment options. (phrma.org)
  • NEW YORK (GenomeWeb) - Single-cell sequencing can help reveal karyotype heterogeneity and may someday inform cancer treatment approaches, according to researchers led by the University of Groningen in the Netherlands. (genomeweb.com)
  • Malchiodi E et al Thyrotropin-secreting pituitary adenomas: outcome of pituitary surgery and irradiation. (thyroid.org)
  • Forbes D, Creamer M, Hawthorne G, Allen N, McHugh T (2003) Comorbidity as a predictor of symptom change after treatment in combat-related Posttraumatic Stress Disorder. (springer.com)
  • The growing trend of implementing immunotherapy into oncology has resulted in various new therapeutic cancer treatments utilizing antibodies. (news-medical.net)
  • Prostate cancer is closely linked to genes which makes it important to personalize prostate cancer treatment and management . (medindia.net)
  • Given prostate cancer's link to hereditary genes, it is important to take a personalized approach to treatment rather than the "one-size fits all" approach. (medindia.net)
  • As the HIV population continues to age, the association of HIV infection with poor breast and prostate cancer outcomes will become more important, especially because prostate cancer is projected to become the most common malignancy in the HIV population by 2020,' said Coghill. (news-medical.net)
  • Studies that have evaluated pain intervention outcomes in patients with LBP have several limitations. (medscape.com)
  • By using PET to determine which patients did not fare well after six weeks of treatment, clinicians were able to switch to a different regimen during chemoradiation and extend median overall survival by nine months. (auntminnie.com)
  • The CIMDRN network brings together clinicians and health evaluative scientists to both generate knowledge and immediately translate this into better health care and outcomes for Canadian children with IEM, and their families. (gc.ca)
  • Finding alternatives to radioactive iodine treatments for radiation-resistant locally advanced or metastatic thyroid tumors has long vexed clinicians. (healio.com)
  • Typically, clinicians will either perform an eyeball test on patients before surgery or before embarking on a course of treatment, or they will use BMI to gauge relative health. (umich.edu)
  • The window between the decision to do surgery and the actual time of surgery provides the perfect opportunity for patients and clinicians to work together to 'train' patients for rapid postoperating recovery and optimal outcome. (umich.edu)
  • Information about the impact of HIV treatment on viral load, the immune system, other health conditions, mortality and quality of life. (aidsmap.com)
  • The health records revealed that around 46.3% of the patients were using cannabis within 1 month of initiating treatment for a first psychotic episode, with use of the drug most common among single men aged 16-25. (medicalnewstoday.com)
  • Given the increased chance of negative health outcomes in trauma-related disorders, there is a great deal of interest in this disorder and its impact on the immune system. (nova.edu)
  • Improved understanding of health outcomes associated with psychotherapy would provide insight into the mechanisms that may help to prevent premature illness among individuals experiencing posttraumatic stress reactions. (nova.edu)
  • It is important for health care providers to have an understanding of the variety of different agents and their device options in order to optimize personalized care of this group of patients and help them to experience increased adherence to the treatment plan (Anzueto & Miravitlles, 2018) . (emaxhealth.com)
  • Financial difficulties may impact the outcome for cancer patients even in countries where the national public health system covers most of the expenses, and therefore, it is our mission to understand what are the determinants of such difficulties and whether some of them may be actionable," said principal investigator Dr. Francesco Perrone, director of the Unità Sperimentazioni Cliniche at the National Cancer Institute of Naples, Italy. (eurekalert.org)
  • A Moffitt Cancer Center researcher, in collaboration with investigators at the National Cancer Institute, Duke University, and Johns Hopkins Bloomberg School of Public Health, took a closer look at the disparity, factoring in whether or not cancer treatment had an impact on outcomes among this patient population. (news-medical.net)
  • MAP Clinical Directors recap five years of outcomes data collection and look to the future of behavioral health. (prweb.com)
  • MAP Health Management, the nation's leader in the advancement of data-driven technology to improve clinical and financial outcomes in behavioral health, has released its first clinically-focused white paper. (prweb.com)
  • Based on the knowledge gleaned from its initial data gathering, MAP has evolved to delivering population health management solutions, predictive analytics, risk management and care coordination - all components to improving outcomes. (prweb.com)
  • MAP Health Management is the nation's leader in the provision of a comprehensive, accessible technology platform designed to improve treatment outcomes for patients treated for addictions and other behavioral health illnesses. (prweb.com)
  • Network members are able to differentiate themselves to behavioral health consumers and health insurance payers by demonstrating treatment success rates. (prweb.com)
  • Tracking health-related outcomes of the group, they find significant increases in treatment intensity at the age 65 barrier, including increases in the number of procedures performed, and total list charges. (rand.org)
  • Card, David, Carlos Dobkin, and Nicole Maestas, The Impact of Health Insurance Status on Treatment Intensity and Health Outcomes. (rand.org)
  • These regimens are frequently hard to tolerate, particularly in children, due to the length of treatment, drug toxicity and the lack of child-friendly formulations,' said one of the authors Prof. Anneke Hesseling from the Desmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University. (news-medical.net)
  • Not only do these approaches improve psychological outcomes such as depression and health-related quality of life, they also reduce patients' experience of pain. (emaxhealth.com)
  • The review reports on 12 pain-related outcomes, including pain intensity, pain interference, depression, health care use, disability and health-related quality of life. (emaxhealth.com)
  • Over the past several decades, health care and outcomes for children who are born with rare genetic diseases that affect the body's ability to break down substances - known as inborn errors of metabolism (IEM) - have greatly improved in Canada. (gc.ca)
  • Psychological treatments for schizophrenia are increasingly popular with mental health practitioners and people with schizophrenia, and also with their families. (researchandmarkets.com)
  • Outcomes Research evaluates the impact of health care on the health outcomes of patients and populations (see AHRQ for further details). (wikipedia.org)
  • The Quality and Outcomes Framework (QOF) is a system for the performance management and payment of general practitioners (GPs) in the National Health Service (NHS) in England, Wales, Scotland and Northern Ireland. (wikipedia.org)
  • This calls for focused evidence-informed strategies to address attrition and improve outcomes. (mendeley.com)
  • It is why we are stressing the need for more research on clinical strategies to improve outcomes for HIV-infected cancer patients. (news-medical.net)
  • MAP's dedicated teams of research analysts, clinical directors, recovery advocates, technology professionals and billing experts work to improve patient outcomes, empower treatment providers with data, reduce costs and drive facility revenue. (prweb.com)
  • The hope is that we can improve outcomes for all our patients. (auntminnie.com)
  • Alternative strategies are needed to improve the outcome of patients who fare badly. (bmj.com)
  • Enhanced awareness of treatment outcome monitoring is essential to improve the coverage and the quality of information. (eurosurveillance.org)
  • From accessing medicines to intellectual property to drug safety, PhRMA is devoted to advancing public policies that support innovative medical research, improve treatments and yield real results. (phrma.org)
  • Patient support and assistance is the top priority for PhRMA's member companies, who are working hard to improve patients' lives through the discovery and development of new medicines and treatments. (phrma.org)
  • For one, the investigators collected information after treatment, so they could not definitively say whether blood-thinner choice and the results of genetic testing caused better patient outcomes. (eurekalert.org)
  • Your doctor compares these numbers with the results of the lab test done at the start of your treatment. (lls.org)
  • Personalized antiplatelet treatment involves choosing a therapy based on the results of platelet function testing, a measurement which shows how effective an antiplatelet drug such as clopidogrel is at inhibiting platelet aggregation. (medindia.net)
  • Providing individualized treatment based on the results of MEA instead of using novel antiplatelet drugs in each patient would save costs of drug therapy of about 410 per patient each year. (medindia.net)
  • The results were similar when analysed by treatment actually received. (bmj.com)
  • The paper showcases the rapid evolvement of the Austin based, data-driven company which has taken empirical outcomes data, interpreted the results, and has begun to demonstrate effective means in which treatment providers can extend the care continuum for discharged patients rendering successful treatment results. (prweb.com)
  • The results show that 78% (764 of 975) of these children had successful treatment outcomes when treated with second-line MDR-TB drugs. (news-medical.net)
  • Although these results were used to update the WHO guidelines, further rigorously collected evidence is needed to help guide the management of MDR-TB treatment in children globally. (news-medical.net)
  • This article presents national results on treatment outcome among patients with pulmonary TB reported in France in 2009 and explores determinants of potentially unfavourable outcome. (eurosurveillance.org)
  • Re-treatment after SMILE by LASIK achieved excellent visual and refractive outcomes, although these results indicate that myopic LASIK retreatment after primary myopic SMILE requires a different nomogram than for myopic LASIK re-treatment after primary myopic LASIK. (healio.com)
  • The birthweight and maturity of viable infants were similar in treated and control groups, and a detailed multivariate analysis confirmed that hypotensive treatment had no effect on fetal growth in utero. (biomedsearch.com)
  • The multivariate nomogram for LASIK re-treatments was used, including sphere, cylinder, age, and primary spherical equivalent (SEQ) as variables. (healio.com)
  • Data will be collected under the supervision of OMNI staff through the following treatment center pilot site participants. (prweb.com)
  • The team enrolled half of the participants into a standard care treatment program, in which they received group therapy twice a week for six months, and then once a week for the next six months. (goodtherapy.org)
  • Our ultimate goal is to use these prognostic tools in the future to guide treatments for our patients," says Patrick Zweidler-McKay, M.D., Ph.D., assistant professor at MD Anderson's Children's Cancer Hospital and first author. (mdanderson.org)
  • Unfortunately, despite frequent changes in COPD classification systems and the emergence of new inhaled therapies recommended from evidence-based guidelines, poor adherence to treatment due to the cost of medication and lack of availability of medications create a gap in real-life prescribing patterns (Cases et al, 2018) . (emaxhealth.com)