A direct-acting vasodilator that is used as an antihypertensive agent.
A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Drugs used to cause dilation of the blood vessels.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.
An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
Dull or sharp aching pain caused by stimulated NOCICEPTORS due to tissue injury, inflammation or diseases. It can be divided into somatic or tissue pain and VISCERAL PAIN.
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma.
A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)
A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
Operations carried out for the correction of deformities and defects, repair of injuries, and diagnosis and cure of certain diseases. (Taber, 18th ed.)
Interventions to provide care prior to, during, and immediately after surgery.
Surgery performed on the thoracic organs, most commonly the lungs and the heart.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Countries that have reached a level of economic achievement through an increase of production, per capita income and consumption, and utilization of natural and human resources.
The period shortly before, during, and immediately after giving birth.
The hollow, muscular organ that maintains the circulation of the blood.
Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
Services providing pharmaceutic and therapeutic drug information and consultation.
Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.
Agents that promote the excretion of urine through their effects on kidney function.
A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.
The state of the ATMOSPHERE over minutes to months.
A medical-surgical specialty concerned with the physiology and disorders primarily of the female genital tract, as well as female endocrinology and reproductive physiology.
A medical-surgical specialty concerned with management and care of women during pregnancy, parturition, and the puerperium.
Hospital department responsible for the administration and management of services provided for obstetric and gynecologic patients.
Surgery performed on the pregnant woman for conditions associated with pregnancy, labor, or the puerperium. It does not include surgery of the newborn infant.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Methods and procedures for the diagnosis of conditions related to pregnancy, labor, and the puerperium and of diseases of the female genitalia. It includes also demonstration of genital and pregnancy physiology.
A publication issued at stated, more or less regular, intervals.
An autosomal dominant porphyria that is due to a deficiency of COPROPORPHYRINOGEN OXIDASE in the LIVER, the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS.
Porphyrins with four methyl and four propionic acid side chains attached to the pyrrole rings. Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA.
An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.
A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Colorless reduced precursors of porphyrins in which the pyrrole rings are linked by methylene (-CH2-) bridges.
Studies have shown that the use of ACE inhibitors and hydralazine can delay surgical treatment of MR. The current guidelines ... There are two surgical options for the treatment of MR: mitral valve replacement and mitral valve repair. Mitral valve repair ... Hoit BD (1991). "Medical treatment of valvular heart disease". Curr. Opin. Cardiol. 6 (2): 207-11. doi:10.1097/00001573- ... In the chronic state, the most commonly used agents are ACE inhibitors and hydralazine. ...
"Deep vein thrombosis - Treatment". nhs.uk. 2017-11-16. Retrieved 2019-07-29. Kouchoukos et al. 2013, pp. 189 & 503. Kouchoukos ... "Beneficial effects of hydralazine in severe mitral regurgitation". Circulation. 58 (2): 273-9. doi:10.1161/01.cir.58.2.273. ... Such medical treatments include diuretics, vasodilators, and ACE inhibitors. Mitral regurgitation Mitral stenosis Artificial ... For individuals with few symptoms, or those with contraindications to surgery, options exist for medical treatment in both ...
Drug treatment options are limited, as many antihypertensives may negatively affect the fetus. Methyldopa, hydralazine, and ... It is the goal of evolutionary medicine to find treatments for diseases that are informed by the evolutionary history of a ... There is no specific treatment, but is monitored closely to rapidly identify pre-eclampsia and its life-threatening ... "preeclampsia/eclampsia" at Dorland's Medical Dictionary Brown CM, Garovic VD (March 2014). "Drug Treatment of Hypertension in ...
Its treatment is mostly a matter of trying to reduce absorption of the drug, if possible, using gastric lavage and monitoring ... Hydralazine. Enhanced hypotensive effect. Monoamine oxidase inhibitors (MAOIs). Advised not to be started until at least 2 ... In the United Kingdom, lofepramine is licensed for the treatment of depression which is its primary use in medicine. To be used ... The drug was first introduced for the treatment of depression in either 1980 or 1983. Lofepramine is the generic name of the ...
The definitive treatment for pre-eclampsia is the delivery of the baby and placenta. The timing of delivery should balance the ... Labetalol, hydralazine and nifedipine are commonly used antihypertensive agents for hypertension in pregnancy. ACE inhibitors ... Treatment can range from expectant management to expedited delivery by induction of labor or Caesarean section, in addition to ... Vissenberg R, van den Boogaard E, van Wely M, van der Post JA, Fliers E, Bisschop PH, Goddijn M (July 2012). "Treatment of ...
Human NAT2 preferentially acetylates isoniazid (treatment for tuberculosis), hydralazine, procainamide, dapsone, ... Drugs affected by this are: isoniazid procainamide hydralazine dapsone sulfasalazine Adverse events from this deficiency ...
Treatment depends on the severity and cause of the disease. In people with chronic stable mild heart failure, treatment ... In people who are intolerant of ACE-I and ARBs or who have significant kidney dysfunction, the use of combined hydralazine and ... Treatment of the underlying cause is usually the first approach to treating heart failure. In the majority of cases, though, ... Treatment of anemia significantly improves quality of life for those with heart failure, often with a reduction in severity of ...
Endovascular treatment with mechanical thrombectomy (MT) is another proven treatment modality in the management of patients ... Hypotensive agents that can be options include labetalol, nicardipine, clevidipine, hydralazine, enalaprilat.[21] For the ... or endovascular treatment with mechanical thrombectomy should be made. Initiation of IV alteplase treatment in the 3 to 4.5- ... Treatment delays may result from failure to ascribe a patient's symptoms to stroke, and furthermore, the risk of harm increases ...
Where relapse occurs, conventional treatment should be resumed, including hydralazine with nitrates plus beta-blockers during ... Treatment for PPCM is similar to treatment for congestive heart failure. Conventional heart failure treatment includes the use ... particularly after changes of medical treatment regimes. Patients who do not respond to initial treatment, defined as left ... If ACE-I is not well tolerated by the patient, it can be replaced by angiotensin receptor blockers (ARB). Hydralazine with ...
Drug treatment includes the rapidly acting vasodilators, including sublingual or topical nitrates or oral hydralazine or ... Topical nitroglycerin ointment is a convenient and safe treatment-an inch or two can be applied to the chest wall or forehead, ... These treatments are used during obstetric delivery of women with autonomic dysreflexia. The cause of autonomic dysreflexia ... Initial treatment involves sitting the patient upright, removing any constrictive clothing (including abdominal binders and ...
... , applied topically, is widely used for the treatment of hair loss. It is effective in helping promote hair growth in ... A comparative study of minoxidil and hydralazine". Circulation. 45 (3): 571-82. doi:10.1161/01.CIR.45.3.571. PMID 4401051. ... Temporary hair loss is a common side effect of minoxidil treatment. Manufacturers note that minoxidil-induced hair loss is a ... PMID 12789195.CS1 maint: uses authors parameter (link) Neumann J. "Hair loss treatment may be dangerous to kids". Reuters. ...
... plus reserpine plus hydralazine versus placebo had to be stopped early because those not receiving treatment developed many ... Historically the treatment for what was called the "hard pulse disease" consisted in reducing the quantity of blood by blood ... Other treatments, such as barbiturates, bismuth, and bromides were mainly supportive rather than therapeutic. Other drugs were ... The study continued in people with lower blood pressures and showed that treatment even in people with mild hypertension more ...
The treatment of DES consists primarily of medications, such as acid suppressing agents (like proton-pump inhibitors), calcium ... Several drugs are used to treat DES, including nitroglycerin, hyoscine butylbromide, calcium channel blockers, hydralazine, and ... Esophageal Spasm~treatment at eMedicine Media related to Diffuse esophageal spasm at Wikimedia Commons Barium swallow images of ... whilst the treatments work in some sufferers, it does not work for everyone. In extremely rare cases, surgery may be considered ...
"An open trial comparing isradipine with hydralazine and methyl dopa in the treatment of patients with severe pre-eclampsia". J ... It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. It ...
Hydralazine and its derivatives are also used in the treatment of severe hypertension, although they should be avoided in ... and Treatment of High Blood Pressure) recommends thiazide-type diuretics to be one of the first-line drug treatments for ... Perry HM, Goldman AI, Lavin MA, Schnaper HW, Fitz AE, Frohlich ED, Steele B, Rickman HG: Evaluation of drug treatment in mild ... "Drug treatment of elevated blood pressure". Australian Prescriber (33): 108-112. Archived from the original on 26 August 2010. ...
GIFT15 is a treatment which suppresses the immune system, and has been successfully used in the treatment of mice. The immune ... Hydralazine: Due to its ability to damage myelin nerve sheaths, acrolein may be a factor in the development of multiple ... Immunoglobulin levels may aid in the prediction of treatment response in anti-CD20 treatment of multiple sclerosis, March 22, ... Treatment in MS phase II studies is with 4-12 months usually shorter than in phase III studies. Amiselimod, S1P modulator ...
... individuals that exhibit similar disease expression may respond differently to identical drug treatments. Selecting treatments ... Some examples include procaine, hydralazine, and procainimide, but they lack specificity and potency making it hard to test ... Pharmacoepigenetic treatment plans can consist of a single epidrug class or combine several in a unique therapy. The following ... Treatments that inhibit DNMT function without attachment to DNA (which can cause toxic effects) show they could be effective ...
Other treatments may include blood pressure medications such as hydralazine and emergency delivery of the baby either vaginally ... Treatment of the mother's seizures may also manage fetal bradycardia. If the risk to the health of the fetus or the mother is ... Current medical diagnosis & treatment 2021. Papadakis, Maxine A.,, McPhee, Stephen J.,, Rabow, Michael W. (Sixtieth ed.). New ... The four goals of the treatment of eclampsia are to stop and prevent further convulsions, to control the elevated blood ...
Hydralazine is a medication used to treat high blood pressure. Approximately 5% of the patients who have taken hydralazine over ... Treatment[edit]. It is important to recognize early that these drugs are causing DIL like symptoms and discontinue use of the ... Hofstra A, Matassa L, Uetrecht J (1991). "Metabolism of hydralazine by activated leukocytes: implications for hydralazine ... Hofstra A (1994). "Metabolism of hydralazine: relevance to drug-induced lupus". Drug Metab Rev. 26 (3): 485-505. doi:10.3109/ ...
Hydralazine and Allopurinol are medications that are prescribed to patients to lower their blood pressure and are vasodilators ... A family history, regional exam and epidemiological cues are usually the most useful information to utilize for treatment ... Proceeding a tissue sample, an effective treatment for follicular hyperplasia is surgical removal of the lesion after an ...
Hydralazine is listed for use in the acute management of severe pregnancy‐induced hypertension only. Its use in the treatment ... To be used for the treatment of Trypanosoma brucei gambiense infection *^ To be used for the treatment of the initial phase of ... Oxamniquine is listed for use when praziquantel treatment fails. *^ Only for the presumptive treatment of epidemic meningitis ... To be used for the treatment of T. b. gambiense infection *^ Only to be used in combination with eflornithine, for the ...
Hydralazine and Sodium nitroprusside are systemic vasodilators, thereby reducing afterload, however can be found to have reflex ... It is estimated that people who do not receive appropriate treatment only live an average of about three years after the event ... In a hypertensive emergency, treatment should first be to stabilize the patient's airway, breathing, and circulation per ACLS ... "Pharmacologic Treatment of Hypertensive Urgency in the Outpatient Setting: A Systematic Review". Journal of General Internal ...
Hydralazine displays tachyphylaxis if given as a monotherapy for antihypertensive treatment. It is administered with a beta- ... Ranitidine, used for acid reflux treatment, can display rapid tachyphylaxis within six weeks of treatment initiation, limiting ... Inhalation of an agonist for the beta-2 adrenergic receptor, such as Salbutamol, Albuterol (US), is the most common treatment ... Desmopressin used in the treatment of type 1 von Willebrand disease is, in general, given every 12-24 hours in limited numbers ...
Oxamniquine is listed for use when praziquantel treatment fails. Only for the presumptive treatment of epidemic meningitis in ... Atenolol should not be used as a first-line agent in uncomplicated hypertension in patients >60 years Hydralazine is listed for ... Combination also indicated for pre-exposure prophylaxis For the treatment of viral haemorrhagic fevers For the treatment of ... For use only for the treatment of P. vivax infection For use only in combination with quinine Only for use to achieve radical ...
Epigenetic treatment with 5-azacytidine (5-AZA) and romidepsin before pembrolizumab administration was tested for safety in a ... hydralazine, 5-Aza-2'-deoxycytidine) and HDAC inhibitors (i.e. romidepsin, belinostat, panobinostat) for clinical use . Several ... Treatment consisted of continuous IV administration of decitabine, followed by 5 days of cytarabine immunotherapy. Patients ... In contrast to DNA mutations which cannot be easily changed through treatment, these aberrant epigenetic changes allow for a ...
... was discovered while scientists at Ciba were looking for a treatment for malaria. It was patented in 1949. It is on ... Hydralazine is commonly used in combination with isosorbide dinitrate for the treatment of congestive heart failure in self- ... Hydralazine has also been studied as a treatment for myelodysplastic syndrome in its capacity as a DNA methyltransferase ... Hydralazine belongs to the hydrazinophthalazine class of drugs. The antihypertensive activity of hydralazine was discovered by ...
A surgical treatment for AI is aortic valve replacement; this is currently an open-heart procedure. In the case of severe acute ... and hydralazine in improving left ventricular wall stress, ejection fraction, and mass. The goal in using these pharmacologic ... Surgical treatment in asymptomatic patients has been recommended if the ejection fraction falls to 50% or below, in the face of ... Health Information and treatment , Patient". Patient. Retrieved 2016-06-04. "Heart Failure Medication: Beta-Blockers, Alpha ...
Hydralazine and its derivatives are also used in the treatment of severe hypertension, although they should be avoided in ... JNC8[who?] recommends calcium channel blockers to be a first-line treatment either as monotherapy or in combination with ... "Drug treatment of elevated blood pressure". Australian Prescriber (33): 108-112. Archived from the original on 26 August 2010. ... Some authors have challenged thiazides as first line treatment.[39][40][41] However, as the Merck Manual of Geriatrics notes, " ...
... such as hydralazine) Infections Acute renal failure Cardiac infarction Rheumatic fever Injury Neoplasms Dressler's syndrome ... 34 Electrolytes LBBB Early repolarization Ventricular hypertrophy Aneurysm Treatment (e.g. pericardiocentesis) Injury (AMI, ...
... was discovered while scientists at Ciba were looking for a treatment for malaria.[3] It was patented in 1949.[4] It ... Hydralazine is commonly used in combination with isosorbide dinitrate for the treatment of congestive heart failure in self- ... Hydralazine has also been studied as a treatment for myelodysplastic syndrome in its capacity as a DNA methyltransferase ... "Hydralazine". International Drug Price Indicator Guide. Retrieved 8 December 2016.. *^ Hamilton, Richart (2015). Tarascon ...
In the treatment of depression the antidepressant effect often becomes evident in the first week of therapy (earlier than ... Moclobemide is useful in the treatment and management of panic disorder.[43] Panic disorder is mentioned as an accepted but ... Heinonen EH, Myllylä V (July 1998). "Safety of selegiline (deprenyl) in the treatment of Parkinson's disease". Drug Saf. 19 (1 ... Nutt D, Montgomery SA (June 1996). "Moclobemide in the treatment of social phobia". Int Clin Psychopharmacol. 11 Suppl 3 (3): ...
... a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain". IDrugs : The ... which was formerly being investigated as an anticonvulsant and neuroprotective and is now under development for the treatment ...
This is a progressive and often lethal disorder, which can be improved but not cured by levodopa.[39] Response to treatment is ...
It may be useful in the treatment of bone metastases.[132]. Bronchoscopy[edit]. Several treatments can be administered via ... DNA methyltransferase inhibitors in development include decitabine, azacytidine, and hydralazine.[59]. The TRACERx project is ... Main article: Treatment of lung cancer. Treatment for lung cancer depends on the cancer's specific cell type, how far it has ... after first treatment, post-treatment, and relapse.[186] By studying samples at different points of tumor development, the ...
Treatment. The treatment of SLE involves preventing flares and reducing their severity and duration when they occur. ... More than 38 medications can cause this condition, the most common of which are procainamide, isoniazid, hydralazine, quinidine ... The treatment plan for these people requires anticoagulation. Often, low-dose aspirin is prescribed for this purpose, although ... Treatment can include corticosteroids and anti-malarial drugs. Certain types of lupus nephritis such as diffuse proliferative ...
To be used for the treatment of Trypanosoma brucei gambiense infection *↑ To be used for the treatment of the initial phase of ... Hydralazine is listed for use in the acute management of severe pregnancy‐induced hypertension only. ... For the treatment of viral haemorrhagic fevers and in combination with pegylated interferons for the treatment of Hepatitis C ... To be used for the treatment of Trypanosoma brucei gambiense infection *↑ Only to be used in combination with eflornithine, for ...
Hydralazine is listed for use in the acute management of severe pregnancy‐induced hypertension only. Its use in the treatment ... To be used for the treatment of Trypanosoma brucei gambiense infection. *↑ To be used for the treatment of the initial phase of ... For the treatment of viral haemorrhagic fevers and in combination with pegylated interferons for the treatment of Hepatitis C. ... Only listed for single‐dose treatment of uncomplicated ano‐genital gonorrhoea. *↑ Do not administer with calcium and avoid in ...
... amphetamine is largely restricted to use in the treatment of attention deficit disorder and phenobarbital in the treatment of ... In 1952 researchers at Ciba discovered the first orally available vasodilator, hydralazine.[53] A major shortcoming of ... Glivec, a drug used in the treatment of several cancers, is marketed by Novartis, one of the world's major pharmaceutical ... Phenobarbital was among the most widely used drugs for the treatment of epilepsy through the 1970s, and as of 2014, remains on ...
... in the treatment of depressive patients". Drug Development Research. 6 (4): 371-384. doi:10.1002/ddr.430060409. ISSN 0272-4391. ...
It has been found to be particularly useful in heart failure due to systolic dysfunction together with hydralazine.[2][1] It is ... Preparations for treatment of wounds and ulcers (D03). Cicatrizants. *epichlorohydrin: Cadexomer iodine ...
... "treatment-resistant".[10] In addition to being a recognized treatment for major depressive disorder, phenelzine is effective in ... In addition, phenethylamine is a substrate for MAO-B, and treatment with MAOIs that inhibit MAO-B such as phenelzine have been ... Phenelzine usually requires six to eight weeks of treatment, and a minimum dose of 60 mg/day, to achieve therapeutic effects. ... Because of this, upon phenelzine treatment being ceased, its effects typically do not actually wear off until the body ...
... evidence-based treatment options to help patients, caregivers and professionals work effectively together. ... Isosorbide dinitrate/hydralazine. *Killip class. *Ventricular remodeling. *B-type natriuretic peptide. Dalerayan[mag-edit , ...
It has been used in the treatment of muscular tremors and vestibular nystagmus".[5] ...
In 1952 researchers at Ciba discovered the first orally available vasodilator, hydralazine. A major shortcoming of hydralazine ... amphetamine is largely restricted to use in the treatment of attention deficit disorder and phenobarbital in the treatment of ... Treatments must represent 'value for money' and a net benefit to society. There are special rules for certain rare diseases (" ... Phenobarbital was among the most widely used drugs for the treatment of epilepsy through the 1970s, and as of 2014, remains on ...
... before effective pharmacological treatment for hypertension became possible, three treatment modalities were used, all with ... hydralazine, and reserpine (derived from the medicinal plant Rauvolfia serpentina). None of these were well tolerated. A major ... The effect of treatment of blood pressure between 130/80 mmHg and 160/100 mmHg is less clear, with some reviews finding benefit ... The treatment of moderately high arterial blood pressure (defined as >160/100 mmHg) with medications is associated with an ...
DR4 is associated with extraarticular rheumatoid arthritis, hydralazine-induced female systemic lupus erythematosus, pemphigoid ... "Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis". Science. 281 (5377): 703-6. doi: ... "Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility". Lancet. 1 (8178): 1107-9. doi ...
Biopsy should also be done if the location of fibrosis is atypical or if there is an inadequate response to initial treatment. ... One-third of the cases are secondary to malignancy, medication (methysergide, hydralazine, beta blockers), aortic aneurysm, or ... In the absence of severe urinary tract obstruction (which generally requires surgery with omental wrapping), treatment is ...
... efficacy and safety of IV labetalol were evaluated and compared with the efficacy and safety of IV hydralazine in the treatment ... efficacy and safety of IV labetalol were evaluated and compared with the efficacy and safety of IV hydralazine in the treatment ... In contrast, hydralazine produced significant sinus tachycardia requiring IV propranolol in three patients, two of whom ... Hydralazine / administration & dosage, therapeutic use*. Hypertension / drug therapy*, physiopathology. Labetalol / ...
Intervention/treatment Active Comparator: Hydralazine 24 week course of Hydralazine 25mg 3 times daily for 4 weeks, thereafter ... Intervention/treatment Phase Acute Heart Failure Left Ventricular Dysfunction Drug: Hydralazine Drug: Isosorbide Dinitrate ... Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failure (B-AHEF). The safety and ... Treatment. Official Title:. A Prospective, Placebo-controlled, Double-blind, Randomized Study to Compare Hydralazine-isosorbide ...
Hydralazine) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications ... Treatment. There is no specific antidote.. The gastric contents should be evacuated, taking adequate precautions against ... Hydralazine also maintains or increases renal and cerebral blood flow.. Hydralazine is rapidly absorbed after oral ... Hydralazine is subject to polymorphic acetylation; slow acetylators generally have higher plasma levels of hydralazine and ...
Hydralazine is no longer used as a primary treatment for hypertension but remains an important option for certain types of ... Notes About Hydralazine Only you and your doctor can decide on a proper medication for the treatment of high blood pressure. Be ... While hydralazine has been largely replaced by other drugs for the treatment of high blood pressure, it still plays an ... Side Effects of Hydralazine Hydralazine tends to increase heart rate and may cause fluid retention through its action on the ...
Detailed drug Information for hydralazine and hydrochlorothiazide. Includes common brand names, drug descriptions, warnings, ... The treatment of hypertension is not static but must be reevaluated as conditions in each patient warrant . ... Proper Use of hydralazine and hydrochlorothiazide. Hydralazine and hydrochlorothiazide may cause you to have an unusual feeling ... Uses For hydralazine and hydrochlorothiazide. Hydralazine and hydrochlorothiazide combination is used to treat high blood ...
... includes hydralazine/hydrochlorothiazide/reserpine description, dosage and directions. ... Reserpine, hydralazine, and hydrochlorothiazide (Advanced Reading). Professional resources. Related treatment guides. *High ... hydralazine/. hydrochlorothiazide/. reserpine. Generic Name: hydralazine/. hydrochlorothiazide/. reserpine (hye DRAL a zeen/hye ... Hydralazine/hydrochlorothiazide/reserpine may make you feel dizzy.. Do not stop taking hydralazine/. hydrochlorothiazide/ ...
Hydralazine was discovered in the 1950s as a treatment for malaria. It is a direct smooth muscle vasodilator used as an ... Treatment. The patient admitted and treated with gentle intravenous fluids and a unit of packed red blood cells. Hydralazine ... Hydralazine, a vasodilator, is commonly used as an adjunctive treatment for moderate to severe hypertension, heart failure and ... Treatment includes stopping the hydralazine, appropriate use of immunosuppressants based on the severity and therapeutic ...
Intervention/treatment Phase Hypertension, Pregnancy Induced Hydralazine Adverse Reaction Pre-eclampsia Pre-eclampsia ... Drug: Hydralazine Group B(Hydralazine) will serve as control and will receive active comparator Hydralazine intravenous bolus ... Active Comparator: Hydralazine This group (Hydralazine;Group B) received intravenous Hydralazine and served control. Bolus ... Treatment. Official Title:. Randomized Controlled Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric ...
Hydralazine and Hydrochlorothiazide) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, ... The treatment of hypertension is not static but must be reevaluated as conditions in each patient warrant. ... Hydralazine Although the precise mechanism of action of hydralazine is not fully understood, the major effects are on the ... Hydralazine HCI and hydrochlorothiazide capsules of 25 mg /25 mg contain 25 mg of hydralazine hydrochloride USP and 25 mg of ...
... patients with or without pharmacological treatment are allowed as long as their treatment do not include hydralazine. ... Topotecan hydralazine valproate. Drug: Hydralazine and magnesium valproate Hydralazine and valproate will start from seven days ... Drug Information available for: Hydralazine Valproic acid Hydralazine hydrochloride Valproate sodium Magnesium Divalproex ... hydralazine + valproate for 6 courses every 4 weeks. Patients will receive an oral dose of hydralazine of 182mg (rapid) or 83mg ...
Hydralazine in the long-term treatment of chronic heart failure: Lack of difference from placebo. American Heart Journal. 1982 ... Hydralazine in the long-term treatment of chronic heart failure : Lack of difference from placebo. / Franciosa, Joseph A.; ... title = "Hydralazine in the long-term treatment of chronic heart failure: Lack of difference from placebo", ... Fingerprint Dive into the research topics of Hydralazine in the long-term treatment of chronic heart failure: Lack of ...
For treatment of heart failure: * For oral dosage form (tablets): * Adults-At first, one tablet three times a day. Your doctor ... Hydralazine works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its ... These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may ... Isosorbide dinitrate and hydralazine combination is used to treat heart failure in black patients. ...
Find out what health conditions may be a health risk when taken with Hydralazine Oral ... changing any diet or commencing or discontinuing any course of treatment. ... Drugs & MedicationsHydralazine HCL. Who should not take Hydralazine HCL?. The following conditions are contraindicated with ... WebMD provides common contraindications for Hydralazine Oral. ... WebMD does not provide medical advice, diagnosis or treatment. ...
Hydralazine is an oral and injectable drug used to treat high blood pressure (hypertension). Learn about side effects, warnings ... Hydralazine is used for long-term treatment. It comes with serious risks if you dont take it as prescribed. ... Hydralazine oral tablet is only available as a generic drug.. *Hydralazine is an oral and injectable drug thats used to treat ... What is hydralazine?. Hydralazine is a prescription drug. Its available as an oral tablet and an injection. The injection is ...
... personalized treatment plan to improve and closely manage your hearts overall function. ... Nitrates and Hydralazine. When taken together, nitrates and hydralazine help your hearts blood vessels relax and expand to ... We conduct a thorough medical history and physical exam, and provide a treatment plan often including both medication and ... If the disease continues to progress we may explore other advanced treatment options including surgery and transplant. We focus ...
Heart disease medicines are an important part of your treatment plan. WebMD explains types of heart disease drugs and how they ... Hydralazine *Isosorbide dinitrate (Isordil). *Isosorbide mononitrate (Imdur). * Minoxidil * Nitroglycerin (Minitran, Nitro-bid ... of cholesterol lowering drugs which is used in patients who cannot control their cholesterol through diet and statin treatments ...
Isosorbide Dinitrate and Hydralazine(BiDil) generic is a vasodilator combination, prescribed for heart failure. It dilates ... The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always ... General Information on Isosorbide Dinitrate and Hydralazine. Generic Name : Isosorbide Dinitrate and Hydralazine Pronunciation ... What are the side effects of Isosorbide Dinitrate and Hydralazine? Body as a Whole : Allergic reactions and uneasiness. Central ...
Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis. Less Obstetrics & Gynecology. 103(2):397, ... ZYC101a for Treatment of High-Grade Cervical Intraepithelial Neoplasia: A Randomized Controlled Trial. Garcia, Francisco; Petry ... After 3 years of treatment, raloxifene had no significant effect on the severity, frequency, type, or perceived impact of ...
Hydralazine *Hydrochlorothiazide *Hydroxyzine Hyoscine *Imipramine Iproniazid Isometheptene mucate [Isoniazid] Kebuzone ... Treatment Approach Considerations. The goals in managing an acute attack of porphyria are to decrease heme synthesis and to ... Treatment options for other manifestations are as follows [7] : * Nausea and vomiting - Prochloperazine, promazine, or ... Hereditary Coproporphyria Treatment & Management. Updated: Jan 21, 2015 * Author: Thomas G DeLoughery, MD; Chief Editor: ...
... that nifedipine at an average dose of 40 mg daily caused a fall in blood pressure similar to that achieved with hydralazine in ... resistant hypertension treated long-term with nifedipine and a control group of 102 similar patients treated with hydralazine ... Role of nifedipine in the treatment of resistant hypertension. Comparison with hydralazine in hospital outpatients.. *. Mariela ... article{Murphy1984RoleON, title={Role of nifedipine in the treatment of resistant hypertension. Comparison with hydralazine in ...
Multi-modality Treatment "AK-2123-Radiation-Hyperthermia-Hydralazine" of S-180 Tumor Bearing Mice ... Rao, Satish BS (1990) Multi-modality Treatment "AK-2123-Radiation-Hyperthermia-Hydralazine" of S-180 Tumor Bearing Mice. ...
Hydralazine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Hydralazine is also used after heart valve replacement and in the treatment of heart failure. Talk to your doctor about the ... Hydralazine comes as a tablet to take by mouth. It usually is taken two to four a day. Take hydralazine at around the same ... Hydralazine controls high blood pressure but does not cure it. Continue to take hydralazine even if you feel well. Do not stop ...
... antihypertensive treatment was started with propranolol alone or combined with hydralazine and furosemide. During a treatment ... Progression of nephropathy in long-term diabetics with proteinuria and effect of initial anti-hypertensive treatment Scand J ... Further control studies will clarify whether end-stage of renal insufficiency will be postponed by antihypertensive treatment. ...
Hydralazine was discovered while scientists at Ciba were looking for a treatment for malaria. It was patented in 1949. It is on ... Hydralazine is commonly used in combination with isosorbide dinitrate for the treatment of congestive heart failure in self- ... Hydralazine has also been studied as a treatment for myelodysplastic syndrome in its capacity as a DNA methyltransferase ... Hydralazine belongs to the hydrazinophthalazine class of drugs. The antihypertensive activity of hydralazine was discovered by ...
... avoid nitroprusside and hydralazine. The treatment is based on clinical/radiographic evidence of increased intracranial ... What are the treatment approaches to pediatric hypertension?. What are the treatment approaches to severe hypertension in ... Treatment is indicated if the SBP is above 160 mm Hg and/or the DBP is over 100 mm Hg. Reduce the BP by 20%-30% of baseline. ... Treatment of hypertensive emergencies. Ann Transl Med. 2017 May. 5 (suppl 1):S5. [Medline]. [Full Text]. ...
These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may ...
Comparative analysis Dosage and administration Hypertension in pregnancy Nifedipine Pregnant women Health aspects Treatment ... COMPARISON OF ORAL NIFEDIPINE WITH INTRAVENOUS HYDRALAZINE FOR ACUTE HYPERTENSIVE EMERGENCIES OF PREGNANCY.(Report) by Journal ... of Postgraduate Medical Institute; Health, general Gestational hypertension Drug therapy Research Hydralazine ... 1. Magee LA, Cham C, Waterman EJ, Ohlsson A, von Dadelszen P. Hydralazine for treatment of severe hypertension in pregnancy: ...
Hydralazine) drug information. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, ... The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always ... Drug Name : Hydralazine. Hydralazine(Apresoline) generic Carbetazine is a smooth muscle relaxant, prescribed for essential ... Carbetazine (Hydralazine) Drug Price and Information. Carbetazine is a smooth muscle relaxant, prescribed for essential ...
BiDil (isosorbide dinitrate/hydralazine hydrochloride); NitroMed; For the treatment of heart failure in black patients, ... Muse; Vivus; Treatment for impotence, Approved October 1996. Pravachol (pravastatin sodium); Bristol-Myers Squibb; Treatment ... EDEX; Schwarz Pharma; Treatment for erectile dysfunction, Approved June 1997. Lescol (fluvastatin sodium); Novartis; Treatment ... Diovan (valsartan); Ciba Pharmaceuticals; Treatment for hypertension, Approved January 1997. DynaCirc CR; Novartis; Treatment ...
BiDil (isosorbide dinitrate/hydralazine hydrochloride); NitroMed; For the treatment of heart failure in black patients, ... BiDil (isosorbide dinitrate/hydralazine hydrochloride); NitroMed; For the treatment of heart failure in black patients, ... Baraclude (entecavir); Bristol-Myers Squibb; For the treatment of chronic hepatitis B infections with evidence of active viral ... Baraclude (entecavir); Bristol-Myers Squibb; For the treatment of chronic hepatitis B infections with evidence of active viral ...
  • Appropriate studies have not been performed on the relationship of age to the effects of hydralazine and hydrochlorothiazide combination in the pediatric population. (drugs.com)
  • However, dizziness or lightheadedness or symptoms of too much potassium loss may be more likely to occur in the elderly, who are usually more sensitive to the effects of hydralazine and hydrochlorothiazide. (drugs.com)
  • Monoamine oxidase inhibitors (MAOIs) can increase the effects of hydralazine. (healthline.com)
  • Response, toxicity and survival were evaluated as well as the biological effects of hydralazine and valproate in blood and primary tumor samples. (biomedcentral.com)
  • Isosorbide dinitrate and hydralazine combination is used to treat heart failure in black patients. (mayoclinic.org)
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of isosorbide dinitrate and hydralazine combination in the elderly. (mayoclinic.org)
  • However, elderly patients are more likely to have age-related liver or kidney problems, which may require caution and an adjustment in the dose for patients receiving isosorbide dinitrate and hydralazine combination. (mayoclinic.org)
  • Latest prescription information about Isosorbide Dinitrate and Hydralazine. (medindia.net)
  • Why is Isosorbide Dinitrate and Hydralazine Prescribed? (medindia.net)
  • When should Isosorbide Dinitrate and Hydralazine not to be taken? (medindia.net)
  • What is the dosage of Isosorbide Dinitrate and Hydralazine? (medindia.net)
  • How should Isosorbide Dinitrate and Hydralazine be taken? (medindia.net)
  • What are the warnings and precautions for Isosorbide Dinitrate and Hydralazine? (medindia.net)
  • What are the side effects of Isosorbide Dinitrate and Hydralazine? (medindia.net)
  • Hydralazine is formally known as a direct-acting vasodilator, which means that it works directly on the blood vessels themselves to cause relaxation. (verywellhealth.com)
  • Hydralazine is a vasodilator. (drugs.com)
  • Hydralazine, a vasodilator, is commonly used as an adjunctive treatment for moderate to severe hypertension, heart failure and hypertensive emergencies in pregnancy. (bmj.com)
  • It is a direct smooth muscle vasodilator used as an adjunctive treatment for moderate to severe hypertension, heart failure with reduced ejection fraction (ACE inhibitor or angiotensin receptor blocker intolerance) and in hypertensive emergencies in pregnancy. (bmj.com)
  • Thus long-term vasodilator treatment with hydralazine alone is not significantly more effective than placebo in chronic heart failure. (umn.edu)
  • Hydralazine is in the vasodilator family of medications, so is believed to work by causing the dilation of blood vessels. (wikipedia.org)
  • What are the side effects of BiDil (hydralazine and isosorbide)? (sharecare.com)
  • BiDil (hydralazine and isosorbide dinitrate) Drug Side Effects, Interactions, and Medication Information on eMedicineHealth. (emedicinehealth.com)
  • What is the most important information I should know about hydralazine and isosorbide dinitrate (BiDil)? (emedicinehealth.com)
  • The antihypertensive efficacy and safety of IV labetalol were evaluated and compared with the efficacy and safety of IV hydralazine in the treatment of postoperative hypertension. (biomedsearch.com)
  • In a few resistant patients, up to 300 mg of Apresoline (hydralazine) daily may be required for a significant antihypertensive effect. (rxlist.com)
  • When other potent parenteral antihypertensive drugs, such as diazoxide, are used in combination with hydralazine, patients should be continuously observed for several hours for any excessive fall in blood pressure. (rxlist.com)
  • In such patients hydralazine should be discontinued unless the benefit-to-risk determination requires continued antihypertensive therapy with this drug. (rxlist.com)
  • Hydralazine HCI and hydrochlorothiazide is an antihypertensive - diuretic combination available as capsules for oral administration. (rxlist.com)
  • In 8 patients with constant proteinuria and mean blood pressure of 159/101 mmHg, antihypertensive treatment was started with propranolol alone or combined with hydralazine and furosemide. (nih.gov)
  • Further control studies will clarify whether end-stage of renal insufficiency will be postponed by antihypertensive treatment. (nih.gov)
  • It may potentiate the antihypertensive effects of: Vasodilators Calcium antagonists ACE inhibitors Diuretics Antihypertensives Tricyclic antidepressants Major tranquillisers Ethanol (alcohol) Diazoxide Drugs subject to a strong first-pass effect such as beta blockers may increase the bioavailability of hydralazine. (wikipedia.org)
  • Antihypertensive treatments in obese patients: the Antihype. (lww.com)
  • Although the underlying pathophysiology of the hypertension may differ between lean and obese patients, current guidelines provide limited specific antihypertensive treatment recommendations for obese hypertensive patients. (lww.com)
  • 1 Several clinical studies, such as Perindopril Protection Against Recurrent Stroke Study, Systolic Hypertension in Europe, and Study on Cognition and Prognosis in the Elderly, have shown that antihypertensive drug treatment is associated with reduced cognitive decline. (ahajournals.org)
  • It is particularly important to make and average repeated measurements of blood pressure for the diagnosis of hypertension and titration of antihypertensive treatment. (diabetesjournals.org)
  • Hydralazine Hydrochloride. (verywellhealth.com)
  • Hydralazine hydrochloride, USP is a white to off-white, odorless crystalline powder. (rxlist.com)
  • Hydralazine hydrochloride is 1 hydrazinophthalazine monohydrochloride. (rxlist.com)
  • 25 mg hydralazine hydrochloride and 25 mg hydrochlorothiazide capsules are white and imprinted "Par 143", and are available in bottles of 100 (NDC #49884-1 43-01) 500 (NDC #49884-1 43-05) and 1000 (NDC X49884-1 43-10). (rxlist.com)
  • 100 mg hydralazine hydrochloride and 50 mg hydrochlorothiazide capsules are powder blue/light blue and imprinted "Par 145", and are available in bottles of 100 (NDC #49884-1 45-01), 500 (NDC #49884-145-05) and 1000 (NDC #49884-145-10). (rxlist.com)
  • Administration of hydralazine/nitrates will be superior to placebo administration in reducing HF readmission or death, improving dyspnoea, reducing blood pressure and brain natriuretic peptide (BNP) in African patients admitted with AHF and left ventricular dysfunction. (clinicaltrials.gov)
  • This first multinational study of over 1000 patients with acute decompensated heart failure conducted in all regions of sub-Saharan Africa shows, for the first time, that the treatment of heart failure is sub-optimal in the region, with relatively low proven medical treatments (such as beta-blockers, hydralazine and nitrates) and inappropriately high use of aspirin in a cohort of patients with non-ischaemic heart failure. (clinicaltrials.gov)
  • The use of Ace inhibitors (ACEi) and hydralazine/nitrates has never been examined in patients admitted with acute heart failure. (clinicaltrials.gov)
  • When taken together, nitrates and hydralazine help your heart's blood vessels relax and expand to open wider. (mountsinai.org)
  • In such cases, a lower dosage of Apresoline (hydralazine) combined with a thiazide and/or reserpine or a beta blocker may be considered. (rxlist.com)
  • Adverse reactions with Apresoline (hydralazine) are usually reversible when dosage is reduced. (rxlist.com)
  • The usual dosage is one hydralazine HCl and hydrochlorothiazide capsule twice daily, the strength depending upon individual requirement following titration. (rxlist.com)
  • Adverse reactions are usually reversible upon reduction of dosage or discontinuation of hydralazine HCI and hydrochlorothiazide. (rxlist.com)
  • Standard treatment guidelines should be consulted for information on appropriate dosage forms. (who.int)
  • A 69-year-old patient (weight: NA) from SE with the following symptoms: NA started Simvastatin treatment (dosage: Unk) on NS. (patientsville.com)
  • To determine the superiority of epigenetic therapy with hydralazine and valproate plus topotecan over placebo plus topotecan upon progression-free survival. (clinicaltrials.gov)
  • Epigenetic therapy with hydralazine and valproate associated to cisplatin chemoradiation in FIGO stage IIIB. (biomedcentral.com)
  • Epigenetic therapy with hydralazine and valproate associated to chemoradiation in cervical cancer is well-tolerated and seems effective as all evaluable patients achieved clinical complete response during the external radiation. (biomedcentral.com)
  • Patients will receive an oral dose of hydralazine of 182mg (rapid) or 83mg (slow) according to the acetylator phenotype in a single daily dose and magnesium valproate at an oral dose of 40mg/Kg t.i.d. (clinicaltrials.gov)
  • A survey of 122 patients with resistant hypertension treated long-term with nifedipine and a control group of 102 similar patients treated with hydralazine revealed that nifedipine at an average dose of 40 mg daily caused a fall in blood pressure similar to that achieved with hydralazine in a dose of 86 mg daily. (semanticscholar.org)
  • Hydralazine NAT activities exhibited a robust acetylator gene dose response in cryopreserved human hepatocytes both in vitro and in situ. (aspetjournals.org)
  • showed 15-fold differences in hydralazine plasma concentrations between rapid and slow acetylators of the probe drug sulfamethazine after administration of the same dose of hydralazine. (aspetjournals.org)
  • The dose of hydralazine is individualized, depending on the condition being treated and the person's response to the medication. (medbroadcast.com)
  • The usual recommended dose of hydralazine to treat high blood pressure varies from 10 mg to 50 mg 4 times daily. (medbroadcast.com)
  • To test the potency of hydralazine in the context of neurodegenerative disease, the scientists used a high dose of a chemical stressor called rotenone that is associated with increased risk of Parkinson's disease in humans exposed to high doses. (news-medical.net)
  • besides Enterobacter, Acinetobacter, Bacteroides Dose: Adults 15'3 g IM or IV q6h purchase 20 mg tadalis sx with amex erectile dysfunction after testosterone treatment. (autoportal.ru)
  • Though typically dispensed as a generic drug, hydralazine may sometimes still be found at the brand name drug Apresoline. (verywellhealth.com)
  • Profound hypotensive episodes may occur when diazoxide injection and Apresoline (hydralazine) are used concomitantly. (rxlist.com)
  • Hydralazine, sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure. (wikipedia.org)
  • Hydralazine(Apresoline) generic Carbetazine is a smooth muscle relaxant, prescribed for essential hypertension. (medindia.net)
  • Only you and your doctor can decide on a proper medication for the treatment of high blood pressure. (verywellhealth.com)
  • Hydralazine/hydrochlorothiazide/reserpine may also be used for purposes other than those listed in this medication guide. (drugs.com)
  • We conduct a thorough medical history and physical exam, and provide a treatment plan often including both medication and lifestyle modifications. (mountsinai.org)
  • If you are using this medication, speak with your doctor or pharmacist for information about your treatment options. (medbroadcast.com)
  • Partea i in generic brand cialis cadrul procesului de medication a recipe in luego in treatment growth dysfunction type acestei parti mind therapist. (impressionistic.com)
  • Patients having known contraindications to hydralazine or minoxidil therapy. (knowcancer.com)
  • Hydralazine and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). (drugs.com)
  • Hydralazine and hydrochlorothiazide is available only with your doctor's prescription. (drugs.com)
  • Tell your doctor if you have ever had any unusual or allergic reaction to hydralazine and hydrochlorothiazide or any other medicines. (drugs.com)
  • Although there is no specific information comparing use of hydralazine and hydrochlorothiazide combination in the elderly with use in other age groups, hydralazine and hydrochlorothiazide is not expected to cause different side effects or problems in older people than it does in younger adults. (drugs.com)
  • Also, hydralazine and hydrochlorothiazide may reduce tolerance to cold temperatures in elderly patients. (drugs.com)
  • When you are taking hydralazine and hydrochlorothiazide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. (drugs.com)
  • Using hydralazine and hydrochlorothiazide with any of the following medicines is not recommended. (drugs.com)
  • Hydralazine/hydrochlorothiazide/reserpine may make you feel dizzy. (drugs.com)
  • Hydralazine/hydrochlorothiazide/reserpine may cause dizziness. (drugs.com)
  • Hydralazine/hydrochlorothiazide/reserpine passes into breast milk and may harm a nursing infant. (drugs.com)
  • Do not confuse hydralazine with hydroxyzine or hydrochlorothiazide. (unboundmedicine.com)
  • treatment with hydrochlorothiazide. (proprofs.com)
  • Only 2 trials reported severe persistent hypertension.This review could not conclude about comparative effects due to insufficient data and suggested that further trials should compare Hydralazine with Nifedipine or labetalol, and to report severe persistent hypertension and adverse feto-maternal effects. (clinicaltrials.gov)
  • Role of nifedipine in the treatment of resistant hypertension. (semanticscholar.org)
  • Objective: To compare oral nifedipine with intravenous hydralazine in their rapidity to control hypertensive emergencies of pregnancy. (thefreelibrary.com)
  • The purpose of our research was to compare I/V hydralazine with oral nifedipine in regard to efficacy and safety in controlling the blood pressure. (thefreelibrary.com)
  • Those patients having history of cardiac arrythmias, cardiac failure, wheezy chest, and hypersensitivity to either nifedipine or hydralazine were excluded from the study. (thefreelibrary.com)
  • In the rare circumstance that intravenous bolus labetalol, hydralazine, or immediate release oral nifedipine fails to relieve acute-onset, severe hypertension and is given in successive appropriate doses, emergent consultation with an anesthesiologist, maternal-fetal medicine subspecialist, or critical care subspecialist to discuss second-line intervention is recommended. (acog.org)
  • The use of IV labetalol, IV hydralazine, or immediate release oral nifedipine for the treatment of acute-onset, severe hypertension for pregnant or postpartum patients does not require cardiac monitoring. (acog.org)
  • Hydralazine is often used to treat hypertension in pregnancy, though, with either labetalol and/or methyldopa. (wikipedia.org)
  • OBJECTIVES:1) To compare efficacy and severe persistent hypertension after intravenous Labetalol versus Hydralazine, within maximum 5 drug boluses, in obstetric severe hypertensive patients at Civil Hospital Karachi. (clinicaltrials.gov)
  • The most commonly used antihypertensives to control acute hypertensive crises in pregnancy are intravenous hydralazine, labetalol and short acting orally administered nifidipine especially in patients who may require emergency caesarean section and those who often receive magnesium sulphate. (thefreelibrary.com)
  • Intravenous labetalol and hydralazine have long been considered first-line medications for the management of acute-onset, severe hypertension in pregnant women and women in the postpartum period. (acog.org)
  • Intravenous labetalol or hydralazine may be used to treat severe hypertension in pregnancy because neither agent has demonstrated superior effectiveness. (aafp.org)
  • To investigate the effect of hydralazine isosorbide dinitrate on clinical outcomes, symptoms, cardiac parameters and functional status of African patients hospitalized with AHF and left ventricular dysfunction during 24 weeks of therapy. (clinicaltrials.gov)
  • While there are many different types of vasodilators used in medicine today, none share the chemical or clinical properties of hydralazine. (verywellhealth.com)
  • In a few patients hydralazine may produce a clinical picture simulating systemic lupus erythematosus including glomerulonephritis. (rxlist.com)
  • We use this case to review the current literature and discuss and highlight the importance of a high degree of clinical acumen, early diagnosis and prompt treatment for better clinical outcomes. (bmj.com)
  • Although hydralazine improves cardiac performance in patients with chronic left ventricular failure, its long-term clinical efficacy has not been established in controlled trials. (umn.edu)
  • We found no change in body weight, clinical class, resting heart rate and blood pressure, or heart size (by chest x-ray examination and echocardiogram) during treatment in either group. (umn.edu)
  • The total number of complicating clinical events was insignificantly fewer in the hydralazine treated group (8 vs 13). (umn.edu)
  • Based on these results, we suggest that hydralazine may be a good candidate for clinical trials for the treatment of age-related disorders in humans as it may also offer general health benefits to the aging population,' he said. (news-medical.net)
  • However, few agents currently available for the treatment of acute decompensated heart failure have been definitively shown in large prospective randomized clinical trials to provide meaningful improvements in intermediate-term clinical outcomes. (cmaj.ca)
  • The form collected personal data, data about conditions of the sting, the clinical picture and the treatment with antivenom. (who.int)
  • Given that the pharmacologic treatment of hypertension is an important consideration for the management of CKD, the objective of this review is to survey the clinical pharmacology of the major classes of antihypertensives from a nephrocentric point of view and provide practical insights when using them in patients with CKD and ESKD. (asnjournals.org)
  • 2) hydralazine-induced reversal of epigenic silencing of MPO and proteinase3 (PR3) leading to increased expression of neutrophil autoantigens and (3) a break in tolerance in slow versus fast acetylators of hydralazine. (bmj.com)
  • In addition, these patients had more hydralazine metabolites in their urine than fast acetylators. (wikipedia.org)
  • Patients were randomized and treated for postoperative hypertension with either labetalol (n = 10) or hydralazine (n = 10). (biomedsearch.com)
  • In contrast, hydralazine produced significant sinus tachycardia requiring IV propranolol in three patients, two of whom developed transient ST segment depression. (biomedsearch.com)
  • The African American Heart Failure Trial (A-HeFT) established the benefit of adjunctive administration of isosorbide dinitrate/hydralazine (ISDN/HYD) in addition to standard therapy for African American patients with symptomatic heart failure. (clinicaltrials.gov)
  • While hydralazine has been largely replaced by other drugs for the treatment of high blood pressure, it still plays an important role in certain types of patients, especially patients with newly diagnosed gestational hypertension, and those with severely elevated high blood pressure that does not respond well to other therapies. (verywellhealth.com)
  • These effects are usually countered by giving hydralazine along with other medicines like beta-blockers and diuretics , though this is not always possible in pregnant patients. (verywellhealth.com)
  • MAO inhibitors should be used with caution in patients receiving hydralazine. (rxlist.com)
  • Randomized Controlled Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients. (clinicaltrials.gov)
  • Severe Hypertension in pregnancy demands urgent treatment because of high mortality & morbidity in obstetric patients. (clinicaltrials.gov)
  • METHODS: Total one hundred eighty-four patients with, severe hypertension (systolic blood pressure(S.B.P)≥160 and/or diastolic blood pressure(D.B.P) ≥110 mm Hg) at greater than 28 weeks of pregnancy or upto 72 hours after delivery, were enrolled and randomly allocated to drug A or B. At enrollment, 94 patients were allocated to Labetalol to 96 to Hydralazine through simple randomization. (clinicaltrials.gov)
  • A total of 211 patients (alpha 0.5, power 0.8)with cisplatin-resistant recurrent or persistent cancer will be randomized to topotecan + placebo or topotecan + hydralazine + valproate for 6 courses every 4 weeks. (clinicaltrials.gov)
  • We carried out a double-blind randomized trial of hydralazine (200 mg daily in 16 patients) versus placebo (16 patients) in patients with class III and IV symptoms while they were taking digitalis and diuretics. (umn.edu)
  • Inclusion criteria were: (1) patients with systolic blood pressure (SBP) 160 and or above and/or diastolic blood pressure of 110mmHg and or above, (2) singleton pregnancy, (3) gestational age 20 weeks and more, (4) patients with or without proteinuria, (5) no contraindication to the use of hydralazine or nifidipine. (thefreelibrary.com)
  • Pharmacist may prepare oral solution from hydralazine injection for patients with difficulty swallowing. (unboundmedicine.com)
  • Patients were typed for acetylator phenotype and then oral hydralazine at 182 mg/day or 83 mg/day for rapid and slow-acetylators respectively. (biomedcentral.com)
  • Three patients did not receive brachytherapy: two abandoned treatment during EBRT and one died after the first cycle of chemotherapy. (biomedcentral.com)
  • Nevertheless, at present, conventional cytotoxic chemotherapy is still used in the majority of patients with cancer who require systemic treatment. (biomedcentral.com)
  • Third, blood pressure control is more difficult to achieve, and treatment-resistant arterial hypertension is an important problem in obese patients. (lww.com)
  • The observation that aerobic exercise improved blood pressure in patients with treatment-resistant hypertension is nevertheless promising, although weight loss was not achieved in this study [10] . (lww.com)
  • Approximately 5% of the patients who have taken hydralazine over long periods of time and in high doses have shown DIL-like symptoms. (wikipedia.org)
  • Use of hydralazine-isosorbide dinitrate combination in African American and other race/ethnic group patients with heart failure and reduced left ventricular ejection fraction. (escholarship.org)
  • This side effect report can indicate a possible existence of increased vulnerability to Spironolactone treatment in female patients suffering from NA, resulting in Hypotension . (patientsville.com)
  • Here, we attempt to briefly examine the physiologic rationale for the currently available treatments and summarize the existing evidence for their efficacy, with the goal of informing providers how to optimize their management of patients with acute decompensated heart failure. (cmaj.ca)
  • Stage A HF is the least severe, whereas Stage D HF patients may require specialized treatment such as inotropic support, mechanical support, heart transplantation, or hospice care1. (ispub.com)
  • Treatment of hypertension plays a central role in the management of CKD, including in patients with ESKD. (asnjournals.org)
  • The panel members appointed to the Eighth Joint National Committee (JNC8) found moderately strong evidence to recommend initial or add-on treatment with ACEis or ARBs for hypertension in all patients with CKD to improve kidney outcomes ( 11 ). (asnjournals.org)
  • This classification can help veterinarians effectively identify and treat heart disease, but there is no perfect standard for treating all heart disease patients as they are expected to advance through the stages unless progression is altered by treatment. (cliniciansbrief.com)
  • Comparative hemodynamic effects of labetalol and hydralazine in the treatment of postoperative hypertension. (biomedsearch.com)
  • Labetalol and hydralazine both produced significant reductions in arterial blood pressure (p less than 0.001) within 10 minutes, which lasted at least 2 hours. (biomedsearch.com)
  • Most recent Cochrane systematic review on use of anti hypertensive drugs in pregnancy related hypertension, could include only four trials of comparison of Hydralazine with Labetalol. (clinicaltrials.gov)
  • Hydralazine belongs to a class of drugs called peripheral vasodilators. (healthline.com)
  • Hydralazine belongs to the hydrazinophthalazine class of drugs. (wikipedia.org)
  • Results: Both drugs controlled BP in the given time period but hydralazine was more efficacious in terms of time and doses. (thefreelibrary.com)
  • Drugs subject to a strong first-pass effect such as β-blockers may increase the bioavailability of hydralazine. (wikipedia.org)
  • Drugs that are used in the treatment of high blood pressure are called antihypertensives. (merckmanuals.com)
  • Of the drugs that cause DIL, hydralazine has been found to cause a higher incidence. (wikipedia.org)
  • Using Off-Label Drugs for Cancer Prevention and Adjuvant Treatment. (thefreelibrary.com)
  • tell your doctor and pharmacist if you are allergic to hydralazine, aspirin, tartrazine (a yellow dye in some processed foods and medications), any other medications, or any of the ingredients in hydralazine tablets. (medlineplus.gov)
  • To provide further insights into the role of nitric oxide in the hypertension-Alzheimer disease cross-talk, we studied the effects of nitric oxide blockade in APPPS1 mice using N (ω)-nitro- l -arginine methyl ester ( l -NAME) alone or in combination with hydralazine, to normalize blood pressure. (ahajournals.org)
  • Rarely, hydralazine may cause a serious disease known as drug-induced systemic lupus erythematosus, which causes the immune system to attack normal cells. (verywellhealth.com)
  • Hydralazine-induced lupus was first described in 1953. (bmj.com)
  • 1 Hydralazine is often implicated as a causal factor in drug-induced lupus. (bmj.com)
  • Hydralazine may cause symptoms that can feel like lupus. (healthline.com)
  • Prolonged treatment may cause a syndrome similar to lupus, which can become fatal if the symptoms are not noticed and drug treatment stopped. (wikipedia.org)
  • Hydralazine-induced vasculitis may be misdiagnosed as systemic lupus erythematosus (SLE). (mdedge.com)
  • There is no specific cure for lupus, but treatments are effective at minimizing lupus damage and improving function. (onhealth.com)
  • While there is no cure for lupus, there are many effective medicinal treatments. (onhealth.com)
  • Hydralazine induced lupus and sweet's syndrome. (biomedsearch.com)
  • citation needed] Hydralazine is used to treat severe hypertension, but is not a first-line therapy for essential hypertension. (wikipedia.org)
  • Hydralazine is used in the treatment of essential hypertension and is under investigation for epigenetic therapy in the treatment of neoplastic and renal diseases. (aspetjournals.org)
  • In women without end-organ damage, chronic hypertension in pregnancy does not require treatment unless the patient's blood pressure is persistently greater than 150 to 180/100 to 110 mm Hg. (aafp.org)
  • Epinephrine (adrenaline), by its heart rate-accelerating effects as increased by hydralazine, may lead to toxicity. (wikipedia.org)
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  • EXPECTED OUTCOME: Efficacy, severe persistent hypertension and side effects of Labetalol versus Hydralazine, in our population were determined. (clinicaltrials.gov)
  • Hydralazine oral tablet doesn't cause drowsiness, but it can cause other side effects. (healthline.com)
  • Alcohol can make the side effects from hydralazine worse. (medlineplus.gov)
  • Hydralazine may cause side effects. (medlineplus.gov)
  • To prevent these undesirable side effects, hydralazine is usually prescribed in combination with a beta blocker (e.g., propranolol) and a diuretic. (wikipedia.org)
  • These side effects may go away during treatment as your body adjusts to the medicine. (mayoclinic.org)
  • Life Extension[R] has provided data about using aspirin as an adjuvant cancer treatment for decades. (thefreelibrary.com)
  • Beta blockers ↓ tachycardia from hydralazine (therapy may be combined for this reason). (unboundmedicine.com)
  • Hydralazine and magnesium valproate associated to topotecan will increase progression-free survival from 6 to 9 months as compared with the same regimen of chemotherapy plus placebo. (clinicaltrials.gov)
  • Randomized, Double-Blind, Phase III Trial of Chemotherapy Plus the Transcriptional Therapy Hydralazine and Magnesium Valproate Versus Chemotherapy Plus Placebo in Cisplatin-Resistant Recurrent Ovarian Cancer. (clinicaltrials.gov)
  • Hydralazine and valproate will start from seven days before day 1 of chemotherapy until the end of the sixth course. (clinicaltrials.gov)
  • This study was set to evaluate hydralazine and valproate as epigenetic therapy added to chemoradiation with cisplatin in cervical cancer. (biomedcentral.com)
  • The hydralazine/valproate-induced changes in the expression of genes analyzed by microarrays will be presented in the meeting. (biomedcentral.com)
  • Since acetylator phenotype has been shown to modify plasma levels of hydralazine, acetylator phenotype- or genotype-dependent dosing strategies have been both suggested and implemented (described further in the Discussion ). (aspetjournals.org)
  • Hydralazine oral tablet can interact with other medications, herbs, or vitamins you might be taking. (healthline.com)
  • Examples of medications that can interact with hydralazine are listed below. (healthline.com)
  • Hydralazine is in a class of medications called vasodilators. (medlineplus.gov)
  • Many different medications are used in the treatment of heart failure. (universityhealth.org)
  • Treatment of hypertension with at least 2 or more anti-hypertensive medications with blood pressure remaining greater than 140/90 mmHg. (knowcancer.com)
  • Hydralazine belongs to the class of medications called vasodilators . (medbroadcast.com)
  • Hydralazine has also been studied as a treatment for myelodysplastic syndrome in its capacity as a DNA methyltransferase inhibitor. (wikipedia.org)
  • MCF-7/Adr cells were then subjected to antisense targeting of dnmt1, -3a , and - b genes and to treatment with the DNA methylation inhibitor hydralazine to investigate whether DNA demethylation restores sensitivity to adriamycin. (biomedcentral.com)
  • DNA demethylation through antisense targeting of dnmts or hydralazine restored adriamycin sensitivity of MCF-7/Adr cells to a greater extent than verapamil, a known inhibitor of mdr protein, suggesting that DNA demethylation interferes with the epigenetic reprogramming that participates in the drug-resistant phenotype. (biomedcentral.com)
  • We have identified protein kinase C beta (PKCβ) as a critical mediator of this pathway and demonstrate that the PKCβ inhibitor enzastaurin, and the clinically available anti-hypertensive agent hydralazine, both normalize aortic growth in Marfan mice, in association with reduced PKCβ and ERK1/2 activation. (elifesciences.org)
  • Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. (verywellhealth.com)
  • WebMD does not provide medical advice, diagnosis or treatment. (webmd.com)
  • If you receive a heart failure diagnosis, Mount Sinai Heart's multidisciplinary heart failure team works together to design a comprehensive, personalized treatment plan to improve and closely manage your heart's overall function. (mountsinai.org)
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
  • Always seek the advice of a qualified physician for medical diagnosis and treatment. (medindia.net)
  • Recommendations for the diagnosis and treatment of the acute porphyrias. (medscape.com)
  • It should not be used for medical advice, diagnosis or treatment. (sharecare.com)
  • Heart failure is also expensive, costing the NHS about £360 million a year in diagnosis and management, 60% of which is spent on hospital treatment. (bmj.com)
  • knowcancer.com is intended to be solely for informational purposes and should not be a substitute for professional medical advice, diagnosis or treatment. (knowcancer.com)
  • Despite the high prevalence of this condition and its associated major morbidity and mortality, diagnosis can be difficult, and optimal treatment remains poorly defined. (cmaj.ca)
  • Our review is meant to complement the more comprehensive guidelines for the diagnosis and treatment of acute heart failure issued by the European Society of Cardiology 1 and the Heart Failure Society of America. (cmaj.ca)
  • The rapid diagnosis of acute decompensated heart failure is necessary to initiate appropriate treatment. (cmaj.ca)
  • The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. (stlukes-stl.com)
  • A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. (stlukes-stl.com)
  • About 50-65% of Caucasians, Black, South Indians, and Mexicans are slow acetylators at risk for toxicity, while 80-90% of Eskimos, Japanese, and Chinese are rapid acetylators at risk for decreased levels and treatment failure. (unboundmedicine.com)
  • In this review, we discuss the anti-angiogenic activity of histone deacetylase and DNA methyltransferase inhibitors and their combinations with other targeted (anti-angiogenic) therapeutics in treatment of solid tumors. (springer.com)
  • Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin II receptor blockers (ARBs) are the mainstays of hypertension treatment in CKD. (asnjournals.org)
  • We provide evidence that DNA hypermethylation is at least partly responsible for development of the multidrug-resistant phenotype in the MCF-7/Adr model and that hydralazine, a known DNA demethylating agent, can revert the resistant phenotype. (biomedcentral.com)
  • High oral doses of glucose (400 g/d) can inhibit heme synthesis and are useful for the treatment of mild attacks. (medscape.com)
  • Few doses were required to control BP in case of hydralazine 2.74+-1.35 as compared to nifidipine which was 3.86+-1.45 with a significant 'p' value of 0.000. (thefreelibrary.com)
  • This is most often found with those that take low doses and when used early in the treatment of high blood pressure. (edrugsearch.com)
  • The drug, hydralazine, extended life span about 25 percent in two strains of C. elegans (roundworms), one a wild type and the other bred to generate high levels of a neurotoxic protein called tau that in humans is associated with Alzheimer's disease. (news-medical.net)
  • Seeking treatment licensed humans are free to help you access less-privileged catheter and la pela cialis domenicano story state range. (impressionistic.com)
  • [3] These metabolites (byproducts of the interactions between the drug and constituents in the body) of hydralazine are said to have been created when white blood cells have been activated, meaning they are stimulated to produce a respiratory burst . (wikipedia.org)
  • [7] Further studies on the interactions between oxidants and hydralazine are necessary to understand the processes involved in DIL. (wikipedia.org)
  • Hydralazine is an oral and injectable drug that's used to treat high blood pressure. (healthline.com)
  • Hydralazine controls high blood pressure but does not cure it. (medlineplus.gov)
  • When should treatment for high blood pressure start? (brainscape.com)
  • The treatment that is most suitable for you will depend on your blood pressure readings plus your absolute risk of cardiovascular disease, as well as whether you have any effects from having high blood pressure. (mydr.com.au)
  • In addition to treating high blood pressure, your doctor will recommend treatments for any other risk factors you have for cardiovascular disease. (mydr.com.au)
  • With the wide variety of antihypertensives available, high blood pressure can be controlled in almost anyone, but treatment has to be tailored to the individual. (merckmanuals.com)
  • Our results clearly document NAT2 genotype-dependent N -acetylation of hydralazine in human hepatocytes, suggesting that hydralazine efficacy and safety could be improved by NAT2 genotype-dependent dosing strategies. (aspetjournals.org)
  • Treatment aims to improve symptoms and prevention complications. (medindia.net)
  • Treatment with first-line agents should be expeditious and occur as soon as possible within 30-60 minutes of confirmed severe hypertension to reduce the risk of maternal stroke. (acog.org)
  • Close maternal and fetal monitoring by a physician and nursing staff are advised during the treatment of acute-onset, severe hypertension. (acog.org)
  • The invention is a treatment for coronary conditions by delivering a therapeutic agent to the pericardial space. (freepatentsonline.com)
  • 1. A method of treatment or prevention of a coronary condition comprising: (a) providing a first pharmaceutical composition comprising a therapeutically effective amount of a first therapeutic agent, and (b) administering the first pharmaceutical composition to the pericardial space of a patient. (freepatentsonline.com)
  • You should not receive it if you had an allergic reaction to hydralazine, or if you have coronary artery disease or rheumatic heart disease. (stlukes-stl.com)
  • As a result, The Sub-Saharan Africa Survey of Heart Failure (THESUS HF) study, was initiated in 9 countries in Africa to determine aetiology, treatment, morbidity and mortality of acute heart failure (HF) in the African sub-continent. (clinicaltrials.gov)
  • Previous studies have shown that the administration of ACEi in African Americans with chronic heart failure is less effective and not superior to combined treatment with hydralazine/isosorbide dinitrate. (clinicaltrials.gov)
  • Along with this relaxation, hydralazine also causes an increase in heart rate and an increase in the total amount of blood being pumped by the heart. (verywellhealth.com)
  • Hydralazine tends to increase heart rate and may cause fluid retention through its action on the kidneys. (verywellhealth.com)
  • Hydralazine works by relaxing blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. (drugs.com)
  • Hydralazine may cause a heart attack, especially if you already have heart issues. (healthline.com)
  • Hydralazine is also used after heart valve replacement and in the treatment of heart failure. (medlineplus.gov)
  • It has been found to be particularly useful in heart failure, together with isosorbide dinitrate, for treatment of people of African descent. (wikipedia.org)
  • Hydralazine is not used as a primary drug for treating hypertension because it elicits a reflex sympathetic stimulation of the heart (the baroreceptor reflex). (wikipedia.org)
  • Hydralazine is commonly used in combination with isosorbide dinitrate for the treatment of congestive heart failure in self-identified African-American populations. (wikipedia.org)
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  • Multiple novel therapies are being developed, but previous treatment failures indicate that progress in the management of acute decompensated heart failure is likely to be slow. (cmaj.ca)
  • With a handful of randomized trials over the past 5 years investigating new treatments of acute decompensated heart failure, the field has recently received increasing attention. (cmaj.ca)
  • New research findings and recommendations have made it necessary for the American College of Cardiology and the American Heart Association to revise the guidelines for the treatment of chronic heart failure. (ispub.com)
  • In order to provide consistent guidelines for the treatment of HF, the American College of Cardiology (ACC), American Heart Association (AHA), participants from the American College of Chest Physicians, the Heart Failure Society of America, the International Society for Heart and Lung Transplantation, the American Academy of Family Physicians, and the American College of Physicians-American Society of Internal Medicine formed a writing committee to develop a set of HF guidelines. (ispub.com)
  • Programs have been developed in high income countries that cost-effectively prevent progressive cardiac dysfunction in high risk individuals and apply evidence-based treatments to optimize the overall management of HF. (clinicaltrials.gov)
  • Because BVPs help the heart's left and chambers to beat in a more coordinated fashion, this treatment is called cardiac resynchronization therapy (CST). (universityhealth.org)
  • Hydralazine-induced vasodilation involves opening of high conductance Ca2+-activated K+ channels. (verywellhealth.com)
  • For that reason, it is important to develop treatments to maintain human health as long as possible,' said Dr. Mirzaei, who is also an investigator in the Center for Alzheimer's and Neurodegenerative Diseases, part of the Peter O'Donnell Jr. Brain Institute at UT Southwestern. (news-medical.net)
  • Hydralazine works by causing the muscles which line and surrounding arteries to relax, resulting in dilation and lowered blood pressure. (verywellhealth.com)
  • During a treatment period of 47 days blood pressure was reduced to 143/93 mmHg, and in the same period urinary albumin excretion was reduced significantly from a mean value of 3547 mug/min to 2414 mug/min (P less than 0.01). (nih.gov)
  • On the other hand, hydralazine (0.5 mg/kg per day) did not improve the decrease in avoidance rate, and did not influence cerebral surface blood flow or oxidative stress in hRN/hANG-Tg mice, in spite of a similar reduction of blood pressure to that by olmesartan. (ahajournals.org)
  • However, if such changes do not sufficiently reduce blood pressure, drug treatment is needed. (merckmanuals.com)
  • Different types of antihypertensives reduce blood pressure by different mechanisms, so many different treatment strategies are possible. (merckmanuals.com)
  • Blood pressure normalization with hydralazine did not protect APPPS1 mice from l -NAME-induced deterioration except for cortical amyloid angiopathy, linked to hypertension-induced arterial wall remodeling. (ahajournals.org)
  • Office-based semiautomated oscillometric blood pressure (conventional or office blood pressure) is the conventional method used to diagnose hypertension and monitor treatment response. (diabetesjournals.org)