A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.
The transference of a part of or an entire liver from one human or animal to another.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The transference of a kidney from one human or animal to another.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
The transference of a heart from one human or animal to another.
Transplantation of an individual's own tissue from one site to another site.
The transference of either one or both of the lungs from one human or animal to another.
Transference of an organ between individuals of the same species or between individuals of different species.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
The transference of a pancreas from one human or animal to another.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Elements of limited time intervals, contributing to particular results or situations.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The return of a sign, symptom, or disease after a remission.
Prospective patient listings for appointments or treatments.
Transplantation between animals of different species.
The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.
Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Partial or total replacement of the CORNEA from one human or animal to another.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Theoretical representations that simulate the behavior or activity of immune system, processes, or phenomena. They include the use of mathematical equations, computers, and other electrical equipment.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A dead body, usually a human body.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
Time period from 1901 through 2000 of the common era.
Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
Pathological processes of the LIVER.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Freedom of equipment from actual or potential hazards.
The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Time period from 2001 through 2100 of the common era.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Immunologic techniques involved in diagnosis.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
Techniques used to demonstrate or measure an immune response, and to identify or measure antigens using antibodies.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Therapeutic act or process that initiates a response to a complete or partial remission level.
The transference of a complete HAND, as a composite of many tissue types, from one individual to another.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
The period following a surgical operation.
Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Disease having a short and relatively severe course.
Progenitor cells from which all blood cells derive.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.
The biochemical and electrophysiological interactions between the NERVOUS SYSTEM and IMMUNE SYSTEM.
Protection from an infectious disease agent that is mediated by B- and T- LYMPHOCYTES following exposure to specific antigen, and characterized by IMMUNOLOGIC MEMORY. It can result from either previous infection with that agent or vaccination (IMMUNITY, ACTIVE), or transfer of antibody or lymphocytes from an immune donor (IMMUNIZATION, PASSIVE).
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Antibodies produced by a single clone of cells.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Immunological rejection of leukemia cells following bone marrow transplantation.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A general term for diseases produced by viruses.
Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Substances that are recognized by the immune system and induce an immune reaction.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
An encapsulated lymphatic organ through which venous blood filters.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Hereditary inflammation conditions, characterized by recurrent episodes of systemic inflammation. Common symptoms include recurrent fever, rash, arthritis, fatigue, and secondary AMYLOIDOSIS. Hereditary autoinflammatory diseases are associated with mutations in genes involved in regulation of normal inflammatory process and are not caused by AUTOANTIBODIES, or antigen specific T-LYMPHOCYTES.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Immunological rejection of tumor tissue/cells following bone marrow transplantation.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
Time period from 1801 through 1900 of the common era.
Venoms from animals of the phylum Arthropoda. Those most investigated are from scorpions and spiders of the class Arachnidae and from ant, bee, and wasp families of the Insecta order Hymenoptera. The venoms contain protein toxins, enzymes, and other bioactive substances and may be lethal to man.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Providers of tissues for transplant to non-related individuals.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Tumors or cancer of the LIVER.
Excision of all or part of the liver. (Dorland, 28th ed)
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
Disorders of the blood and blood forming tissues.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Bites and stings inflicted by insects.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
The mucous lining of the LARYNX, consisting of various types of epithelial cells ranging from stratified squamous EPITHELIUM in the upper larynx to ciliated columnar epithelium in the rest of the larynx, mucous GOBLET CELLS, and glands containing both mucous and serous cells.

Donor MHC and adhesion molecules in transplant arteriosclerosis. (1/919)

Transplant-associated arteriosclerosis remains an obstacle to long-term graft survival. To determine the contribution to transplant arteriosclerosis of MHC and adhesion molecules from cells of the donor vasculature, we allografted carotid artery loops from six mutant mouse strains into immunocompetent CBA/CaJ recipients. The donor mice were deficient in either MHC I molecules or MHC II molecules, both MHC I and MHC II molecules, the adhesion molecule P-selectin, intercellular adhesion molecule (ICAM)-1, or both P-selectin and ICAM-1. Donor arteries in which ICAM-1, MHC II, or both MHC I and MHC II were absent showed reductions in neointima formation of 52%, 33%, and 38%, respectively, due primarily to a reduction in smooth muscle cell (SMC) accumulation. In P-selectin-deficient donor arteries, neointima formation did not differ from that in controls. In donor arteries lacking both P-selectin and ICAM-1, the size of the neointima was similar to that in those lacking ICAM-1 alone. In contrast, neointima formation increased by 52% in MHC I-deficient donor arteries. The number of CD4-positive T cells increased by 2.8-fold in MHC I-deficient arteries, and that of alpha-actin-positive SMCs by twofold. These observations indicate that ICAM-1 and MHC II molecules expressed in the donor vessel wall may promote transplant-associated arteriosclerosis. MHC I molecules expressed in the donor may have a protective effect.  (+info)

Effective treatment of autoimmune disease and progressive renal disease by mixed bone-marrow transplantation that establishes a stable mixed chimerism in BXSB recipient mice. (2/919)

Male BXSB mice spontaneously develop autoimmune disease with features similar to systemic lupus erythematosus. To determine whether this autoimmune disease can be treated as well as prevented by bone-marrow transplantation (BMT) and, at the same time, whether the immunity functions of lethally irradiated recipients can be reconstituted fully, male BXSB mice were engrafted with mixed T cell-depleted marrow (TCDM) both from fully allogeneic autoimmune-resistant BALB/c mice and from syngeneic autoimmune-prone BXSB mice, after the onset of autoimmune disease in the recipient mice. BMT with mixed TCDM from both resistant and susceptible strains of mice (mixed BMT) established stable mixed chimerism, prolonged the median life span, and arrested development of glomerulonephritis in BXSB mice. BMT with mixed TCDM also reduced the formation of anti-DNA antibodies that are observed typically in male mice of this strain. Furthermore, mixed BMT reconstituted the primary antibody production in BXSB recipients impressively. These findings indicate that transplantation of allogeneic autoimmune-resistant TCDM plus syngeneic autoimmune-prone TCDM into lethally irradiated BXSB mice can be used to treat autoimmune and renal disease in this strain of mice. In addition, this dual bone-marrow transplantation reconstitutes the immunity functions and avoids the immunodeficiencies that occur regularly in fully allogeneic chimeras after total body irradiation. This report describes an effective treatment of progressive renal disease and autoimmunity by establishing a stable mixed chimerism of TCDM transplantation from allogeneic autoimmune-resistant BALB/c mice plus syngeneic autoimmune-prone BXSB mice into BXSB mice.  (+info)

Immune reconstitution after bone marrow transplantation for combined immunodeficiencies: down-modulation of Bcl-2 and high expression of CD95/Fas account for increased susceptibility to spontaneous and activation-induced lymphocyte cell death. (3/919)

We have studied the regeneration of T cell subsets and function after BMT in 21 children affected by combined immunodeficiency after BMT. In the first months, the striking predominance of CD4+ cells displayed the primed CD45R0+ phenotype and a high number of activated (HLA-DR+) T cells were observed. Regeneration of naive CD4+CD45RA+ cells correlated with the recovery of proliferative responses to mitogens (r = 0.64, P<0.001). Peripheral blood lymphocytes circulating after BMT undergo an increased process of in vitro cell death, resulting from two mechanisms: spontaneous apoptosis (SA), a consequence of defective production of IL-2 and down-regulation of Bcl-2 (P = 0.02 vs. healthy controls), and high susceptibility to activation-induced cell death (AICD) after restimulation with mitogens. In accordance with the role of CD95/Fas in this latter process, we have observed a high level of CD95 expression (P<0.001 vs. healthy controls), correlated with AICD (P<0.001) but not with SA, and decreasing with time after BMT (P<0.001). Both SA and AICD levels correlated with the presence of activated T cells and decreased with the progressive recovery of T cell proliferative response. Therefore, the lymphocyte hyperactivated status might explain their susceptibility to apoptosis and contribute to the genesis of immunodeficiency that follows BMT.  (+info)

Increasing mixed haematopoietic chimaerism after BMT with total depletion of CD4+ and partial depletion of CD8+ lymphocytes is associated with a higher incidence of relapse. (4/919)

In this study we analysed the incidence and clinical impact of the persistence of host haemopoiesis (mixed chimaerism, MC) after allogeneic BMT in 35 consecutive patients with haematologic malignancies using a total CD4+ cell-depleted graft with an adjusted dose of CD8+ cells (1x10(8)/kg). Chimaerism was assessed by PCR amplification of VNTRs in 30 evaluable patients: 19 non-CML and 11 CML cases which were also evaluated for the BCR-ABL transcript by RT-PCR. All but one had complete engraftment with a donor profile early post-BMT. At the end of the study period, 12 of 30 patients displayed MC (40%). The overall disease-free survival for MC patients was clearly unfavourable when compared to those who exhibited a donor profile (24.7% vs. 100%, P = 0.005). However, we found that only two of five patients with MC in the non-CML group relapsed, whereas a clear correlation could be made between MC and relapse in CML (seven showed MC, preceding cytogenetic or haematological relapse in six of them, which displayed a prior BCR-ABL mRNA positivity). In addition, a quantitative-PCR approach enabled us to demonstrate that increasing amounts of MC are invariably associated with subsequent relapse, whereas a low stable level of host or complete donor haemopoiesis is consistent with clinical complete remission. Although these results suggest that the clinical impact of MC may depend on the underlying disease, it is compatible with the concept that the graft-versus-leukaemia effect against CML is mainly exerted by donor CD4+ lymphocytes. Elimination of this cellular subset may be responsible for the inability of the graft to prevent a progressive increase in the tumor cell burden.  (+info)

Immune reconstitution following allogeneic peripheral blood stem cell transplants. (5/919)

Growth factor-mobilized peripheral blood stem cells (PBSCs) engraft rapidly in myeloablated recipients compared to conventional BM, but this procedure also mobilizes mature lymphocytes and monocytes which can impact immune reconstitution and GVHD. Hence, we serially evaluated immune reconstitution and cytokine expression in PBSCT recipients in the first year. Engraftment of neutrophils and monocytes stabilized early but NK cells, B cells and CD4+ T cell numbers were significantly (P < 0.05) low with persistently reversed CD4:CD8 ratios. NK function remained low throughout the first year. The quantitative decrease in CD4+ T cells resulted in significantly decreased proliferation in response to mitogens and alloHLA antigens. Yet, a qualitative analysis of T cell function measured by Ca++ influx after T cell activation with antiCD3 as well as T-dependent polyclonal Ig secretion by mitogen-stimulated B cells was preserved even early post transplant. TNF alpha mRNA was detected in almost all recipients in the first year. IL-10 mRNA was detected in 77%, IL-2 in 22% and IFN gamma in 44% of recipients in the first 6 months. Only 30% expressed IL-10 in the second 6 months post transplant while expression of IL-2 and IFN gamma was detected in 38% and 46% respectively. Thirty-seven percent of PBSCT recipients developed grades II-IV acute GVHD but 72% went on to develop chronic extensive GVHD at a median of 120 days. Sixty-two percent developed CMV viremia and 5.4% developed overt CMV disease in the first year post PBSCT. Lymphocyte engraftment is quantitatively delayed but CD4 functions are preserved while NK numbers and function are compromised post PBSCT. IL-10 expression decreases after the first 6 months post transplant while TNF alpha is continually expressed. The balance between quantitative lymphocyte reconstitution and qualitative lymphocyte functions as well as changes in lymphokine patterns may influence infection and GVHD and thus the clinical outcome post PBSCT.  (+info)

Effective T cell regeneration following high-dose chemotherapy rescued with CD34+ cell enriched peripheral blood progenitor cells in children. (6/919)

The ex vivo enrichment for the CD34+ cell fraction of PBPC, while it retains the capacity to restore haematopoiesis and potentially reduces a contamination by tumour cells, implements a depletion of T cells. To test whether such a setting adversely affects T cell reconstitution, we monitored T cells in four paediatric patients after CD34+ selected PBPC transplantation. The dose of CD34+ cells, which were enriched to 74%, median, was 7.1 x 10(6)/kg, median, that of T cells was 0.071 x 10(6)/kg, median. The patients were homogenous with respect to features with a potential to effect T cell reconstitution (low median age, (35 years); stage IV malignant tumours in first CR, uncomplicated post-treatment course). The results of sequential FACS analyses showed that by 9 months after treatment all four patients had recovered (1) a normal T cell count (CD3+ cells 1434/microl, median); (2) a normal CD4+ cell count (816/microl, median), while CD8+ cells were recovered (>330/microl) already by 3 months; (3) a normal CD4/CD8 ratio (1.8, median), as a result of an augmented growth of CD4+ cells between 3 and 6 months (increase of CD4+ cells 4.9-fold, median, CD8+ cells 1.1-fold, median). Expansion of cells with a CD45RA+ phenotype (thymus-derived T cells) predominated; from 3 to 6 months the increase of CD4+/CD45RA+ T cells was 130-fold, that of CD4+/CD45RO+ cells was 1.7-fold; CD8+/CD45RA+ cells increased 9-fold, CD8+/CD45RO+ cells increased 2.1-fold, indicating effective thymopoiesis. The findings demonstrate that in paediatric patients the setting of HD-CTX rescued with autologous CD34+ selected PBPC per se is not predictive of an impaired T cell recovery. High thymic activity may be a key factor for the rapid restoration of T cells.  (+info)

Mice with Th2-biased immune systems accept orthotopic corneal allografts placed in "high risk" eyes. (7/919)

CD4+ T cells of the Th1 type play a central role in acute rejection of solid tissue grafts, including orthotopic corneal allografts. Th1 cells, which mediate delayed hypersensitivity, are the polar opposites of CD4+ Th2 cells, and the latter cells cross-regulate Th1 cells through the unique pattern of cytokines they secrete. As such, Th2 cells may have a useful role to play in preventing rejection of corneal allografts. To test this possibility, the immune systems of adult mice were biased toward Th2 responses by immunization with keyhole limpet hemocyanin plus IFA. When immunized subsequently with either OVA or allogeneic corneal tissue, these mice acquired Ag-specific primed T cells of the Th2 type. More important, allogeneic corneas grafted into neovascularized eyes of Th2-biased mice experienced significantly enhanced survival. To demonstrate that enhanced survival was promoted by donor-specific Th2 cells, lymphoid cells from keyhole limpet hemocyanin-immune mice bearing healthy corneal allografts suppressed orthotopic corneal allograft rejection when adoptively transferred into naive, syngeneic recipients. We conclude that acceptance of corneal allografts in neovascularized mouse eyes can be significantly enhanced by biasing the recipient immune system toward Th2 responses.  (+info)

Chronic rejection of mouse kidney allografts. (8/919)

BACKGROUND: Chronic renal allograft rejection is the leading cause of late graft failure. However, its pathogenesis has not been defined. METHODS: To explore the pathogenesis of chronic rejection, we studied a mouse model of kidney transplantation and examined the effects of altering the expression of donor major histocompatibility complex (MHC) antigens on the development of chronic rejection. RESULTS: We found that long-surviving mouse kidney allografts develop pathological abnormalities that resemble chronic rejection in humans. Furthermore, the absence of MHC class I or class II antigens did not prevent the loss of graft function nor alter the pathological characteristics of chronic rejection. Expression of transforming growth factor-beta (TGF-beta), a pleiotropic cytokine suggested to play a role in chronic rejection, was markedly enhanced in control allografts compared with isografts. However, TGF-beta up-regulation was significantly blunted in MHC-deficient grafts. Nonetheless, these differences in TGF-beta expression did not affect the character of chronic rejection, including intrarenal accumulation of collagens. CONCLUSIONS: Reduced expression of either class I or II direct allorecognition pathways is insufficient to prevent the development of chronic rejection, despite a reduction in the levels of TGF-beta expressed in the allograft. This suggests that the severity of chronic rejection is independent of the level of MHC disparity between donor and recipient and the level of TGF-beta expression within the allograft.  (+info)

The thymus, spleen, and lymph nodes were studied in runt disease induced by a graft of intravenously injected homologous splenic cells into newborn rats and mice. Adult Long-Evans cells (70 x 106) were injected into Sprague-Dawley rats. Adult DBA cells (7 x 106) were injected into C57BL/6 mice. Runted rats were sacrificed at 14 to 28 days of age; mice at 10 to 20 days. The thymic cortex is depleted of small lymphocytes. Those remaining are severely damaged and phagocytized. Evidence of damage includes swelling of mitochondria, myelin figure formation, margination of chromatin, and sharp angulation in nuclear contour. Large numbers of macrophages are present. Epithelial-reticular cells which envelop small cortical blood vessels are often retracted, with the result that the most peripheral layer in the thymic-blood barrier suffers abnormally large gaps. Lymphocytes of the periarterial lymphatic sheaths of spleen and of the cortex of lymph nodes are reduced in number and damaged. Vast numbers of ...
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Summary Simian virus 40 (SV40)-transformed cells express the SV40-specific tumour transplantation antigen (TSTA) on the cell surface and the SV40-coded tumour antigen in their nuclei. TSTA is defined by SV40-specific transplantation immunity, whereas T-antigen (T-Ag) can be detected serologically by indirect immunofluorescence. Both antigens, however, are derived from the A gene of SV40. We therefore analysed SV40-transformed cells for the presence of serologically detectable T-Ag-related molecules. Such antigens could not be detected on the surface of living SV40-transformed cells in monolayers. However, after a short formaldehyde fixation it was possible to stain the cell surfaces of SV40-transformed cells with sera from rabbits immunized with purified SDS-denatured T-Ag, but not with sera from hamsters bearing SV40-induced tumours. T-Ag-related antigens could be detected with both types of antisera by applying a more sensitive 125I-protein A assay. The T-Ag specificity of the binding of hamster SV40
As we want all the information on Hypertension Solutions to be as accurate as possible we pass the responsibility of researching and writing the articles on Hypertension Solutions to real Doctors and the name of the Doctor that has researched and written the article will be at the bottom of each article.. ...
T Regulatory cells (Treg) play an important role in the induction and maintenance of immunological tolerance to self and alloantigens. Recent findings in experimental transplant models have demonstrated that Treg can control acute and delayed allograft rejection. Preclinical attempts to use Treg as a cellular therapy have been successfully undertaken demonstrating the safety and feasibility of such treatment, suggesting that they have therapeutic potential. © 2011 by Elsevier Inc. All rights reserved.
Heart Transplantation - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
Heart Transplantation - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
Steinmetz, M; Winoto, A; Minard, K; and Hood, L, Clusters of genes encoding mouse transplantation antigens. (1982). Subject Strain Bibliography 1982. 3024 ...
TY - JOUR. T1 - Tissue-specific, peptide-binding transplantation antigens. T2 - Lessons from the Qa-2 system. AU - Stroynowski, Iwona. PY - 1995. Y1 - 1995. UR - http://www.scopus.com/inward/record.url?scp=0028991945&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0028991945&partnerID=8YFLogxK. M3 - Article. SP - 90. EP - 108. JO - Immunological Reviews. JF - Immunological Reviews. SN - 0105-2896. IS - 147. ER - ...
Graft‐versus‐host disease (GVHD) represents a special situation in transplantation immunology in which immunocompetent donor cells are engrafted into recipients that are incapable of rejecting them due to tolerance, immaturity, or radiation‐ or chemotherapy‐induced immune deficiency
Dr Sebastiaan Heidt is an associate professor working in the laboratory of Transplantation Immunology of Leiden University Medical Center, the Netherlands. After obtaining his PhD at Leiden University on the characterization of B cells in ...
Définitions de Diagnostic_immunology, synonymes, antonymes, dérivés de Diagnostic_immunology, dictionnaire analogique de Diagnostic_immunology (anglais)
Walzer T; Chiossone L; Chaix J; Calver A; Carozzo C; Garrigue-Antar L; Jacques Y; Baratin M; Tomasello E; Vivier E; Nature Immunology, 2007, vol. 8, issue 12, p 1337, ISSN 15292916. ISBN 15292916. ...
Since the first successful transplant of a kidney between identical twins in 1955, transplantation has progressed from being an experimental procedure to a routine clinical therapy offering immense benefits for patients with organ failure, but the survival of transplanted organs remains limited by the bodys immune responses, and many of the complications of transplantation result from the crude nature of our attempts to suppress these....
Tsakraklides, E; Smith, C; Kersey, J H.; and Good, R A., Transplantation antigens (h-2) on virally and chemically transformed balb/3t3 fibroblasts in culture. (1974). Subject Strain Bibliography 1974. 1195 ...
Browse from thousands of Immunology questions and answers (Q&A). Become a part of our community of millions and ask any question that you do not find in our Immunology Q&A library.
The cross-reactivity between the tumor-specific antigen of ascites mouse mammary Tumor MM102 and that of primary spontaneous mammary carcinomas (p-SMC) was studied with the absorption test of specific antiserum and the transplantation immunity test. Anti-MM102 antiserum produced in the syngeneic host (C3H/He mouse) was completely absorbed by established mammary tumor virus (MTV)-induced cell lines derived from various strains of mice but was not absorbed by p-SMC. C3H/He mice which acquired a heightened resistance against transplantation of MM102 showed a low degree of induced resistance to p-SMC. C3H/He mice immunized with p-SMC acquired a heightened resistance against not only p-SMC but also MM102. These results led to the conclusion that some common tumor-specific transplantation antigen exists for MM102 and p-SMC, although the amount of the common antigen was markedly less in p-SMC than in MM102. No differences between MTV-infected C3H/He mice and MTV-free C3Hf mice were observed in the ...
In the context of solid organ transplantation, the exact interactions between the innate and adaptive alloimmune response have not yet been fully explored. In this transplant setting, natural killer (NK) cells have emerged as a particular focus of interest because of their ability to distinguish all …
Transplantation immunology, accommodation, immunologic properties and genomic stability of stem cells, genetic basis of cell transformation and oncogenesis. ...
Read Comparison of cell counting methods from the Society for Mucosal Immunology, an organization dedicated to research in the field of mucosal immunology.
Liquichek Immunology Control,Liquichek Immunology Control is a trilevel, liquid, comprehensive serum protein control with assayed values for a wide number of methods.,medicine,medical supply,medical supplies,medical product
Activity of the hair follicle is cyclic, periods of hair-growth alternating with periods of quiescence during which the dead hair is retained as a club. In the rat, hair-growth occurs in a series of waves which start ventrally and pass over the flanks to the back (Dry, 1926; Butcher, 1934; Johnson, 1958a).. The object of our work was to find out how far such activity is dependent upon factors within the follicle and how far it is subject to systemic control. When hair follicles are translocated, either by rotation of grafts in the mid-flank or by transposition of flaps in two stages, they continue to maintain the periodicity characteristic of their sites of origin (Ebling & Johnson, 1959). Vascularization of such follicles is always consequent upon follicular activity, even when this is out of phase with the normal waves of hair-growth on the adjacent body.. ...
2016. Ardan, T., Němcová, L., Bohuslavová, B., Klezlová, A., Popelka, Š., Studenovská, H.3, Hrnčiarová, E., Čejková, J., Motlík, J.: (2016) Reduced Levels of Tissue Inhibitors of Metalloproteinases (TIMPs) in UVB Irradiated Corneal Epithelium. Photochem. Photobiol., IN PRESS IF 2.008. Bílková, B., Albrecht, T., Chudičková, M., Holáň, V., Piálek, J., Vinkler, M.: (2016) Application of Concanavalin A during immune responsiveness skin-swelling tests facilitates measurement interpretation in mammalian ecology. Ecology and Evolution, 6 (13): 4551-4564. IF 2.537. Čejka, Č., Čejková, J., Trošan, P., Zajícová, A., Syková, E., Holáň, V.: (2016) Transfer of mesenchymal stem cells and cyclosporine A on alkali-injured rabbit cornea using nanofiber scaffolds strongly reduces corneal neovascularization and scar formation. Histol. Histopath., 31: 969-980. IF 1.875. Čejka, Č., Holáň, V., Trošan, P., Zajicová, A., Javorková E., Čejková, J.: (2016) The Favorable Effect of ...
Covers all areas of immunology including cellular and molecular immunology, immunochemistry, immunogenetics, imaging, mathematical modelling, allergy, transplantation immunology, cancer immunology, clinical immunology and immunological therapies, physiological functioning of the immune system in states of both health and disease, malfunctions of the immune system in immunological disorders and therapies (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection), the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.. ...
A big diversity of events takes place at the Max Planck Institute of Immunobiology and Epigenetics (MPI-IE). Weekly internal and public scientific seminars are complemented by events on a (bi/tri)annual basis ...
Seminars in Immunology is a review journal dedicated to keeping scientists informed of developments in the field of immunology on a topic by topic...
Recurrent MCs and experience 3rd potential now. Braverman IVF & Reproductive Immunology takes the time to answer this question and more, so call today!
BioLegend offers a wide array of Rat Immunology Products. BioLegend develops and manufactures world-class, cutting-edge immunological reagents for biomedical research, offered at an outstanding value.
BioLegend offers a wide array of Mouse Immunology Products. BioLegend develops and manufactures world-class, cutting-edge immunological reagents for biomedical research, offered at an outstanding value.
Read Hepatitis C: Current Controversies and Future Potential in Solid Organ Transplantation, Current Infectious Disease Reports on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Islet transplantation has been reported to induce allosensitization in the majority of type 1 diabetic recipients of fresh or shortly incubated islet grafts prepared from one to three donors ...
Originally aired on January 20, 2016 • 3:00 pm ET • Hosted by the Community of Basic Scientists DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance (Link to abstract: a subscription to Journal of Experimental Medicine is required to view the full article, AST is not permitted to distribute the full text of the article) Author: Jordi Ochando, PhD • Mount Sanai School of Medicine Moderator: Heth R. Turnquist, PhD • University of Pittsburgh
TY - JOUR. T1 - Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. AU - Garcia, M.R.. AU - Ledgerwood, L.. AU - Yang, Y.. AU - Xu, J.N.. AU - Lal, G.. AU - Burrell, B.. AU - Ma, G.. AU - Hashimoto, D.. AU - Li, Y.S.. AU - Boros, P.. AU - Grisotto, M.. AU - van Rooijen, N.. AU - Matesanz, R.. AU - Tacke, F. AU - Ginhoux, F.. AU - Ding, Y.Z.. AU - Chen, S.H.. AU - Randolph, GJ. AU - Merad, M.. AU - Bromberg, J.S.. AU - Ochando, J.C.. PY - 2010. Y1 - 2010. U2 - 10.1172/JCI41628. DO - 10.1172/JCI41628. M3 - Article. C2 - 20551515. VL - 120. SP - 2486. EP - 2496. JO - Journal of Clinical Investigation. JF - Journal of Clinical Investigation. SN - 0021-9738. IS - 7. ER - ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Nonhuman Primate Transplantation Tolerance (U01) RFA-AI-16-007. NIAID
Gentaur molecular products has all kinds of products like :SeraLab , SeraLab \ Guinea Pig Serum \ GEM-100-130-J for more molecular products just contact us
Background: Cyclosporin A (CsA) has been a cornerstone of solid organ transplantation since its introduction to the market in the early 1980s, and is a major part of the success of immunosuppression in the clinical setting ...
Research outputs, collaborations and relationships for Yale Department of Immunobiology published between 1 January 2017 - 31 December 2017 as tracked by the Nature Index.
TY - JOUR. T1 - Regenerative medicine as applied to solid organ transplantation. T2 - Current status and future challenges. AU - Orlando, Giuseppe. AU - Baptista, Pedro. AU - Birchall, Martin. AU - De Coppi, Paolo. AU - Farney, Alan. AU - Guimaraes-Souza, Nadia K.. AU - Opara, Emmanuel. AU - Rogers, Jeffrey. AU - Seliktar, Dror. AU - Shapira-Schweitzer, Keren. AU - Stratta, Robert J.. AU - Atala, Anthony. AU - Wood, Kathryn J.. AU - Soker, Shay. PY - 2011/3. Y1 - 2011/3. N2 - In the last two decades, regenerative medicine has shown the potential for bench-to-bedside translational research in specific clinical settings. Progress made in cell and stem cell biology, material sciences and tissue engineering enabled researchers to develop cutting-edge technology which has lead to the creation of nonmodular tissue constructs such as skin, bladders, vessels and upper airways. In all cases, autologous cells were seeded on either artificial or natural supporting scaffolds. However, such constructs were ...
Graham Pawelec, Ph.D., Habil earned his MA in Natural Sciences in 1978 and his Ph.D. in Transplantation Immunology in 1982 from the University of Cambridge, UK, and his Dr. habil and Venia Legendi from the University of Tübingen, Germany, where he became Professor of Experimental Immunology in 1997. From 1999 to 2017 he led the Tübingen Ageing and Tumour Immunology (TATI) group within the Second Department of Internal Medicine, University of Tübingen Hospitals System. He remains affiliated part-time with the department at the Center for Medical Research, University of Tübingen.
The cross-match is a direct compatibility test. It consists in the incubation of RBC from the blood unit with the plasma from the receiver. If the receiver has antibodies against antigens present on the RBC, there will be agglutination, direct or via antiglobulin reaction.
The mission of the ROTRF is to advance the science of solid organ transplantation in order to improve the care of the thousands of patients undergoing transplantation every year.
Agilex Biolabs, Australias largest and most technologically advanced specialist bioanalytical laboratory for clinical trials, today announced it will showcase its world-class immunoassay and immunobiology services for regulated bioanalysis at Bio-Europe 2021.
Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system. | Immunology for University Students
Immunity join our community. We offer 88 Products in our store. Our store specialize in supplying special featured herbal medecines, developed to improve your life and makes better your health. Immunology.
Tate Gisslen, Manuel Alvarez, Casey Wells, Man-Ting Soo, Donna S Lambers, Christine L Knox, Jareen K Meinzen-Derr, Claire A Chougnet, Alan H Jobe, Suhas G Kallapur ...
Organ transplantation is one of the best therapeutic options for patients with end-stage organ failure. Experimental organ transplantation is an important link between basic science and clinical practice. Both editors, Dr. Chen and Dr. Qian, have been working in this area for more than 20 years. Experts from the United States, Canada, China, Japan, Italy, Spain, Turkey, Switzerland, Hungary, and Brazil contributed 25 chapters in this book, and provided detailed descriptions of techniques for vascularized organ allografts in mice, rats, pigs, and nonhuman primates, as well as detailed descriptions of non-vascularized pancreatic islet and spleen allografts.. Furthermore, they discussed new advances in transplantation immunology. This book provides numerous important references which were carefully selected by the authors to extend their visions and knowledge. The appropriate readers of this book include medical students, graduate students, residents, surgeons, physicians and immunologists ...
Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
From experimental observations on induction of transplantation tolerance, we discuss a model that accounts for tissue-specific tolerance to antigens not
Transplantation has become standard of care to treat end-organ failure, replacing a failed organ with a functioning one. However, the toxicity of the immunosuppressive ag..
The Immune Tolerance Network (ITN) is a collaborative network for clinical research focused on the development of therapeutic approaches for asthma and allergy, autoimmune diseases, type 1 diabetes and solid organ transplantation that lead to immune tolerance. These tolerogenic approaches aim to reprogram the immune system so that disease-causing immune responses are stopped while maintaining the immune systems ability to combat pathogen infection.
Transplants of tissues depleted of passenger leukocytes are upon in vitro culture usually accepted in allogeneic recipients. Accordingly, fully allogeneic
protocol for immunostaining primery cells - posted in Immunology: I want to stain primery cells in suspension for cofocal microscopy.(until today I had no problems with immunostaining cell which were grown on coverslips, but now its more complicated situation because the cells are much more sensitive) help? thanksHanna
Nossos profissionais nativos, com títulos de doutorado e mestrado, revisam artigos acadêmicos de Diagnostic immunology para proporcionar inglês de alta qualidade ao seu manuscrito.
Transplantation and Clinical Immunology. 29: 229-236. doi:10.1007/978-0-585-38142-8_28. ISBN 978-0-7923-4937-2.. Fischell, Tim ... including subsequent combined heart and lung transplantation and then isolated lung transplantation. This core programmatic ... "Cardiac Transplantation, co-authored with N. Shumway, S.W. Jamieson and Philip E. Oyer, in George M. Abouna's Current Status of ... In addition to transplantation, Stinson was active in the entire spectrum of adult cardiac surgery and developed special ...
... pioneer of transplantation immunology. First woman appointed to a Professorship in the faculty of Medicine (USYD). Pro-Vice ...
"Immunology of Organ Transplantation". en.ustc.findplus.cn (in Chinese (China)). Retrieved 31 July 2017. Children in Need: ... Immunology of Organ Transplantation. Surgery. July 2014. "The Magazine of The City of London School Alumni Association Autumn ... "Immune Desensitization Allows Pediatric Blood Group Incompatible Kidney Transplantation". Transplantation. 101 (6): 1242-1246. ... He continues to lecture on 3D printing in transplantation. Chandak was invited as one of the key speakers discussing the early ...
List of London medical students who assisted at Belsen Brent, Leslie (1997). A history of Transplantation Immunology. Academic ...
... (1972). Nature's Transplant: The Transplantation Immunology of Viviparity. Butterworths. ISBN 0407326502 ... was a Scottish consultant surgeon and cancer specialist whose research focused on tissue transplantation, cancer immunology and ... 1970). The Biology and Surgery of Tissue Transplantation: Proceedings of a Conference Held in Glasgow on 20-21 March 1969. ... John Maxwell Anderson (1970). The biology and surgery of tissue transplantation. Blackwell Scientific. ISBN 063206210X. ...
Chinen J, Buckley RH (2010). "Transplantation immunology: solid organ and bone marrow". J. Allergy Clin. Immunol. 125 (2 Suppl ... Owen, Judith; Punt, Jenni (2013). Kuby Immunology. New York: W.H. Freeman and Company. "CONVERSION OF NORMAL RATS INTO SCID- ... The most common treatment for SCID is bone marrow transplantation, which has been very successful using either a matched ... David Vetter, the original "bubble boy", had one of the first transplantations also, but eventually died because of an ...
"Immunologically privileged sites in transplantation immunology and oncology". Perspect Biol Med. 29 (1): 115-131. doi:10.1353/ ... IMMUNOLOGY - CHAPTER ONE > INNATE (NON-SPECIFIC) IMMUNITY Gene Mayer, Ph.D. Immunology Section of Microbiology and Immunology ... 2000). "RANTES binding and down-regulation by a novel human perpesvirus-6 beta chemokine receptor". Journal of Immunology. 164 ... Head, JR; Billingham RE (1985). "Immune privilege in the testis:evaluation of potential local factors for transplantation". ...
"Paediatric Immunology, Bone Marrow Transplantation and Infectious Diseases". Newcastle Hospitals. Retrieved 15 April 2018. "The ...
They are used for research in immunology and transplantation. Severe combined immunodeficiency (SCID) mice, with an almost ... Pillai S. "History of Immunology at Harvard". Immunology.HMS.Harvard.edu. Harvard Medical School. Archived from the original on ... Immunology. 4 (12): 989-97. doi:10.1038/nri1502. PMID 15573133. S2CID 21204695. Chandrasekera PC, Pippin JJ (21 November 2013 ... 1985). "Genetic differences in BALB/c sublines". Current Topics in Microbiology and Immunology. 122: 19-30. doi:10.1007/978-3- ...
v t e (Immunology, Organ transplantation, All stub articles, Immunology stubs). ... "Passenger Lymphocyte Syndrome and Liver Transplantation". Clinical and Developmental Immunology. 2008: 715769. doi:10.1155/2008 ... History of immunology Thaunat, Olivier; Morelon, Emmanuel (2007). "Modulation of Immunogenicity". In Lanzetta, Marco; Dubernard ... In tissue and organ transplantation, the passenger leukocyte theory is the proposition that leucocytes within a transplanted ...
Robert Montgomery, MD: Immunology, Pig Organs, and the Future of Transplantation". 28 April 2022. (All articles with unsourced ... Robert Montgomery, MD: Immunology, Pig Organs, and the Future of Transplantation". 28 April 2022. "Robert A. Montgomery". ... He then finished his clinical training in Multi-Organ Transplantation at Johns Hopkins from 1997-1999 after which he joined the ... In 2003 Montgomery became Chief of the Division of Transplantation and Director of the Comprehensive Transplant Center at Johns ...
Astellas' franchise areas are oncology, urology, immunology (transplantation), cardiology, and infectious disease. Priority ...
His interests are dendritic cell immunology, cell transplantation, liver research, and immunity. His highest cited paper is " ... Angus W. Thomson is an American immunologist currently Distinguished Professor of Surgery and Immunology at Starzl Institute, ... "Angus Thomson". University of Pittsburgh Department of Immunology. Morelli, Adrian E.; Thomson, Angus W. (August 2007). " ... "Angus W. Thomson". University of Pittsburgh Starzl Transplantation Institute. " ...
... immunology and bone marrow transplantation at the Dana Farber Cancer Institute (1986-1989). Caligiuri published his first ... That single event inspired him to pursue immunology and clinical transplantation as a career. Following graduation from medical ... Michael A. Caligiuri, M.D. is a physician scientist focused on oncology and immunology. He is currently the president of the ... He trained in human immunology at the Dana Farber Cancer Institute in the laboratory of Jerome Ritz, from 1987-1989, focused ...
For more than 17 years he operated a laboratory in transplantation immunology at Massachusetts General Hospital. In 1998, he ... In 2005, Auchincloss was elected president of the American Society of Transplantation. He has authored scientific articles and ... founded the Juvenile Diabetes Research Foundation Center for Islet Transplantation and served as its director until 2003. He ...
A number of research deal with the development of a strategy utilizing this phenomenon in transplantation immunology. The goal ... CS1: long volume value, Orphaned articles from September 2017, All orphaned articles, Transplantation medicine, Immunology, ... In 1989 was successfully induced classical transplantation tolerance to skin grafts in adult mice using antibodies blocking T ... Gershon, R. K. (1975). "A disquisition on suppressor T cells". Transplantation Reviews. 26: 170-185. doi:10.1111/j.1600-065x. ...
Simpson, E. (2015). "Medawar's legacy to cellular immunology and clinical transplantation: a commentary on Billingham, Brent ... Ono, Santa Jeremy (2004). "The Birth of Transplantation Immunology: the Billingham--Medawar Experiments at Birmingham ... It directly laid the foundation for the first successful organ transplantation in humans, specifically kidney transplantation, ... For his scientific works he is regarded as the "father of transplantation". He is remembered for his wit both in person and in ...
Seminars in Immunology. Advances in Transplantation. 23 (4): 304-313. doi:10.1016/j.smim.2011.04.001. PMC 3836227. PMID ... Conforti L (February 2012). "The ion channel network in T lymphocytes, a target for immunotherapy". Clinical Immunology. 142 (2 ... Stolp J, Zaitsu M, Wood KJ (2019). "Immune Tolerance and Rejection in Organ Transplantation". Immunological Tolerance. Methods ... It has been tested on transplantations, rheumatoid arthritis, type 1 diabetes and other autoimmune disorders. Immunotherapy can ...
The scope of the journal includes stem cell biology, transplantation immunology, translational research, and clinical results ... Bone Marrow Transplantation is a peer-reviewed medical journal covering transplantation of bone marrow in humans. It is ... Bone Marrow Transplantation is abstracted and indexed in BIOBASE/Current Awareness in Biological Sciences, BIOSIS, Current ... "Bone Marrow Transplantation". 2020 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2021. Official ...
The availability of primates from the nearby primate center and an active programme in transplantation immunology, added to his ... Lung transplantation as a case study". Ann Surg. 218 (4): 465-73, discussion 474-5. doi:10.1097/00000658-199310000-00007. PMC ... Reemtsma spent many years investigating the possibility of non-human islet cell transplantation for diabetes mellitus and in ... Reemtsma, K; Giraldo, N; Depp, DA; Eichwald, EJ (1968). "Islet cell transplantation". Ann Surg. 168 (3): 436-46. doi:10.1097/ ...
In 2007, the Stanford Institute for Immunology, Transplantation and Infection cosponsored the program (called the CCIS/ITI ... The program was initially run by the Center for Clinical Immunology at Stanford. The goals of the program included increasing ... Admitted students choose one of eight institutes (Immunology, Stem Cell Biology, Neurobiology, Cardiovascular Medicine, Cancer ... immunology and cardiovascular medicine. The program was renamed the Stanford Institutes of Medicine Summer Research Program, or ...
The following year, he began a four-year term on Transplantation, Tolerance and Tumor Immunology Study Section within the NIH. ... "Kunle Odunsi, MD, PhD, FRCOG, FACOG, Elected to Lead AACR Immunology Working Group". ascopost.com. January 25, 2020. Retrieved ... "Roswell Park Deputy Director Named to NIH Immunology Grant Review Board". roswellpark.org. July 27, 2017. Retrieved May 28, ... He was also elected as the Cancer Immunology Working Group (CIMM) Chairperson-Elect for 2020-2021. During the COVID-19 pandemic ...
... transplantation (biology, immunology and treatment), cancer immunology, and radiation health effects and accident response. He ... He is an editor, co-editor and reviewer of many scientific journals in hematology, oncology, immunology, transplantation and ... In 1976 he received a Ph.D. in microbiology and immunology from the University of California at Los Angeles (UCLA) following ... From 1993 to 1999, Gale was Senior Physician and Corporate Director of Bone Marrow and Blood Cell Transplantation at Salick ...
In transplantation, autologous lymphocytes refers to a person's own white blood cells. Lymphocytes have a number of roles in ... National Cancer Institute Definition of autologous lymphocyte NCI: autologous lymphocyte v t e (All stub articles, Immunology ...
... described the male-specific antigen and helped establish the foundations of transplantation immunology. He organized the first ... Transplantation Bulletin and its successor, Transplantation, for more than 30 years; and chaired the Transplantation Committee ... Eichwald, E.J.; Transplantation Society (1984). Eichwald Festschrift: Dedicated to Ernst J. Eichwald, M.D., on the Occasion of ... In Utah, the focus of his research began to change from transplanted tumors to transplantation of normal tissues. He was a ...
Immunology. 7 (8): 650-4. doi:10.1038/nri2137. PMID 17653127. S2CID 10713893. Giannoukakis N, Phillips B, Finegold D, Harnaha J ... This can occur, for example, when an allogeneic transplantation patient develops an immune reaction to donor antigens, or when ... Immunology. 7 (8): 610-21. doi:10.1038/nri2132. PMID 17627284. S2CID 6587584. Hilkens CM, Isaacs JD (May 2013). "Tolerogenic ... Research using animal models in transplantation and autoimmune diseases has led to early-phase human trials of tolerogenic ...
Peter Morris set up a tissue typing laboratory and a research laboratory in transplantation immunology in Ewing's department to ... His department established an early programme of renal transplantation in Australia. He was born on 6 July 1912 at 53 Dudley ... "Sir Peter J. Morris, AC, FRS". Transplantation. 99 (4): 651-653. doi:10.1097/tp.0000000000000713. "Witness to the History of ... "Experiences with cadaveric renal transplantation with a report of 11 patients". The Medical Journal of Australia. 1 (22): 921- ...
... was an Irish nephrologist known for her research in the immunology of kidney transplantation. Sandomir, Richard (3 July 2021 ...
Ezzelarab M, Thomson AW (August 2011). "Tolerogenic dendritic cells and their role in transplantation". Seminars in Immunology ... Immunology. 7 (8): 610-21. doi:10.1038/nri2132. PMID 17627284. S2CID 6587584. (Immunology, Immune system, Cell biology). ... Immunology. 4 (12): 941-52. doi:10.1038/nri1498. PMID 15573129. S2CID 8931570. Ghiringhelli F, Puig PE, Roux S, Parcellier A, ... Advances in Immunology. Vol. 108. pp. 111-65. doi:10.1016/B978-0-12-380995-7.00004-5. ISBN 9780123809957. PMC 3050492. PMID ...
Immune system, Immunology Transplant rejection Tissue typing Major histocompatibility complex (MHC) The ability to discriminate ... Transplantation medicine, Evolutionary biology, Articles containing video clips). ... Sherman LA, Chattopadhyay S (1993). "The Molecular Basis of Allorecognition". Annual Review of Immunology. 11: 385-402. doi: ... Janeway, Charles A.; Medzhitov, Ruslan (2002-01-01). "Innate immune recognition". Annual Review of Immunology. 20: 197-216. doi ...
Liu X, Lieberman J (April 2020). "Knocking 'em Dead: Pore-Forming Proteins in Immune Defense". Annual Review of Immunology. 38 ... Krensky AM, Clayberger C (August 2005). "Granulysin: a novel host defense molecule". American Journal of Transplantation. 5 (8 ... Sparrow E, Bodman-Smith MD (January 2020). "Granulysin: The attractive side of a natural born killer" (PDF). Immunology Letters ... July 2003). "Granulysin in human serum as a marker of cell-mediated immunity". European Journal of Immunology. 33 (7): 1925- ...
May 2018). "Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndrome: Comparison of Outcomes between CD34+ ... Journal of Immunology. 133 (1): 157-165. PMID 6586833. Tindle RW, Nichols RA, Chan L, Campana D, Catovsky D, Birnie GD (1985 ... Selected and Unmodified Hematopoietic Stem Cell Transplantation". Biology of Blood and Marrow Transplantation. 24 (5): 1079- ... Immunology. 96 (2): 202-206. doi:10.1046/j.1365-2567.1999.00674.x. PMC 2326741. PMID 10233696. Bistrup A, Bhakta S, Lee JK, ...
She is a past President of the Federation of Clinical Immunology Societies, and is a member of the Austrian Academy of Sciences ... Blood and Marrow Transplantation and Cellular Therapy) at Stanford University. She is also the Director of the Stanford ... "Leadership". Federation of Clinical Immunology Societies. 4 June 2018. Retrieved 26 June 2021. "Maria Grazia Roncarolo". Human ... Frontiers in Immunology. 5: 16. doi:10.3389/fimmu.2014.00016. ISSN 1664-3224. PMC 3907718. PMID 24550909. Roncarolo, Maria ...
Immunology Letters. 52 (1): 9-13. doi:10.1016/0165-2478(96)02572-2. PMID 8877413. Slowik V, Apte U (2017). "Leukocyte Cell- ... in serum LECT 2 levels during the early period of liver regeneration after adult living related donor liver transplantation". ...
Before his work on problems of the bladder and prostate, his early research involved the study of the immunology of ... In 2014, he spoke at Pakistan's Sindh Institute of Urology & Transplantation with proposals to assist Pakistani surgeons with ...
Mitchison's contributions to immunology include the discovery of both low dose and high dose tolerance for a single antigen, a ... Mitchison discovered the transference of transplantation immunity by sensitised cells, thereby providing evidence relating ... He was also a founder member of the British Society for Immunology alongside John H. Humphrey, Bob White, and Robin Coombs. ... He holds an Honorary Doctorate from the Weizmann Institute and in 1995 was awarded the Novartis Prize for Basic Immunology. In ...
... pioneer in the field of HLA and immunogenetics of transplantation, the founder of the international organ exchange organization ... pioneer in the area of immunology of reproduction William Coley (1862-1936), pioneer of cancer immunotherapy Albert Coons (1912 ... Immunology lists, Lists of biologists by field, Immunologists). ...
In 1988, he first coordinated a study in successfully demonstrating clinical utility of cord blood transplantation to cure a ... and Professor of Microbiology and Immunology at the Indiana University School of Medicine. He received a BS degree from City ... Work from his laboratory established the field of clinical cord blood transplantation. He died from thyroid cancer on 8 ... 1989 Oct 26; 321(17): 1174-8 Indiana University's Hal Broxmeyer, pioneer of cord blood transplantation, dies at 77 "E Donnall ...
Immunology. 4 (9): 665-674. doi:10.1038/nri1435. PMID 15343366. S2CID 8449323. Aspinall R, Andrew D (July 2000). "Thymic ... Immune system aging in mice can be partly restricted by restoring thymus growth, which can be achieved by transplantation of ... June 2005). "The influence of age on T cell generation and TCR diversity". Journal of Immunology. 174 (11): 7446-7452. doi: ... Haq K, McElhaney JE (August 2014). "Immunosenescence: Influenza vaccination and the elderly". Current Opinion in Immunology. 29 ...
Transplantation research has shown, that donor Tr1 in response to recipient alloantigens, was found to correlate with the ... Immunology. 7 (8): 585-598. doi:10.1038/nri2138. ISSN 1474-1733. PMID 17653126. S2CID 7043844. Weston, L. E.; Geczy, A. F.; ... Immunology. 7 (8): 650-654. doi:10.1038/nri2137. ISSN 1474-1733. PMID 17653127. S2CID 10713893. Roncarolo, Maria-Grazia; ... Trends in Immunology. 24 (12): 619-622. doi:10.1016/j.it.2003.10.001. ISSN 1471-4906. PMID 14644131. Levings, M. K.; Roncarolo ...
One emerging therapy is hematopoietic stem cell transplantation, which has been considered standard treatment for many combined ... Immunology. Medscape. WebMD. Archived from the original on 22 May 2022. Retrieved 31 May 2022. (Articles with short description ... Frontiers in Immunology. 5: 626. doi:10.3389/fimmu.2014.00626. ISSN 1664-3224. OCLC 731654964. PMC 4259107. PMID 25538710. ... Journal of Allergy and Clinical Immunology. 129 (3): 801-810.e6. doi:10.1016/j.jaci.2011.09.027. PMID 22035880. Geraedts, JPM; ...
Paul Ehrlich: Scientist in the fields of hematology, immunology, and chemotherapy, and Nobel laureate. Developed an effective ... Pioneer of skin transplantation and cosmetic surgery. Ernst Dickmanns: Developer of the first driverless car. Otto Diels: Diels ...
His interest in immunology has led to publications in HIV disease, cellular activation and natural killer cell function, tumor ... platelet activation in vascular disease and stem cell transplantation in cancer patients. Publications in endocrinology cover ... Clinical Immunology and Immunopathology, 1997:122-128. Wilczynski J, K. Cypryk, K. Strauss, R. Mazze. The role of Staged ... Clinical Immunology and Immunopathology, 1994; 70:152-158. Hulstaert F, J. Albrecht, I. Hannet, P. Lancaster, L. Buchner, J. ...
Theobald Smith) Peter Hotez (Distinguished Research Professor and Professor of Microbiology, Immunology, and Tropical Medicine ... and expert in transplantation) Vincent T. DeVita (Oncologist) Thomas Grogan (Chief Scientific Officer at Ventana) Albert W. ...
Journal of Immunology, 2006 PMID 17056525 HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent. Jin YJ, ... Journal of the American Society of Blood and Marrow Transplantation, 2004 PMID 15205666 Rapamycin-resistant proliferation of ... Journal of Immunology, 2005 PMID 16116206 CD4 phosphorylation partially reverses Nef down-regulation of CD4. Jin YJ, Zhang X, ... Journal of Immunology, 2004 PMID 15494497 Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell ...
Journal of Allergy and Clinical Immunology. Fong, P. P.; Huminski, P. T.; D'Urso, L. M. (1998). "Induction and potentiation of ... during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation". ...
Somatic cell nuclear transplantation has become a focus of study in stem cell research. The aim of carrying out this procedure ... American Journal of Reproductive Immunology. 50 (2): 113-123. doi:10.1034/j.1600-0897.2003.00064.x. ISSN 1600-0897. PMID ...
"Stem cell transplantation for primary immunodeficiencies". Bone Marrow Transplantation. 41 (S2): S83-S86. doi:10.1038/bmt. ... McCusker, Christine; Warrington, Richard (December 2011). "Primary immunodeficiency". Allergy, Asthma & Clinical Immunology. 7 ... Virus-specific T-lymphocytes (VST) therapy is used for patients who have received hematopoietic stem cell transplantation that ... Journal of Clinical Immunology. 40 (1): 24-64. doi:10.1007/s10875-019-00737-x. PMC 7082301. PMID 31953710. Lim MS, Elenitoba- ...
In 1954 Joseph Murray, J. Hartwell Harrison and others accomplished the first kidney transplantation. Transplantations of other ... ISBN 978-0-313-34101-4. Linton DS (2005). Emil Von Behring: Infectious Disease, Immunology, Serum Therapy. American ...
Helbig G (February 2018). "Imatinib for the treatment of hypereosinophilic syndromes". Expert Review of Clinical Immunology. 14 ... the aggressive chemotherapy and/or bone marrow transplantation used to treat aggressive leukemia may be required. While the ... Roufosse F (2015). "Management of Hypereosinophilic Syndromes". Immunology and Allergy Clinics of North America. 35 (3): 561-75 ...
Due to disease progression, 40% of patients eventually require liver transplantation, which has survival rates (91% at 1 year, ... 2012). "Sex differences associated with primary biliary cirrhosis". Clinical & Developmental Immunology. 2012: 610504. doi: ... This drug stimulates biliary bicarbonate secretion, improves survival without having to resort to a liver transplantation, and ... Kamath BM, Schwarz KB, Hadzić N (January 2010). "Alagille syndrome and liver transplantation". Journal of Pediatric ...
Immunology. 5 (8): 606-16. doi:10.1038/nri1669. PMID 16056254. S2CID 3258595. Sahin, NE; Oner, Z; Oner, S; Turan, MK (10 ... vein and its tributaries Spleen Laparoscopic view of human spleen Asplenia with cardiovascular anomalies Spleen transplantation ... Jia, T; Pamer, EG (2009). "Immunology. Dispensable but not irrelevant". Science. 325 (5940): 549-50. Bibcode:2009Sci...325.. ...
IL-1α has been administered to patients during receiving autologous bone marrow transplantation. The treatment with 50 ng/kg IL ... Moore KW, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR (1993). "Interleukin-10". Annual Review of Immunology. 11: 165-90 ... Neta R, Douches S, Oppenheim JJ (Apr 1986). "Interleukin 1 is a radioprotector". Journal of Immunology. 136 (7): 2483-5. PMID ... Properties of the mediator(s) from adherent cells". Cellular Immunology. 11 (1-3): 162-9. doi:10.1016/0008-8749(74)90016-1. ...
Long E, Wood KJ (August 2007). "Understanding FOXP3: progress towards achieving transplantation tolerance". Transplantation. 84 ... Immunology. 9 (11): 811-6. doi:10.1038/nri2654. PMC 3075537. PMID 19809471. Murphy KM, Stockinger B (August 2010). "Effector T ... IL-6 or IL-21 is being debated by immunology laboratories as the definitive signaling molecule. Murine studies point to IL-6 ... Ziegler SF (January 2007). "FOXP3: not just for regulatory T cells anymore". European Journal of Immunology. 37 (1): 21-3. doi: ...
Transplantation and Infection Federation of Clinical Immunology Societies (FOCIS) (Webarchive template wayback links, CS1 maint ... Council of ASCI; President of the Clinical Immunology Society; President of the Federation of Clinical Immunology Societies; ... Transplantation and Infection ITI at Stanford and Director of the Center for Clinical Immunology at Stanford (CCIS). He was ... Director of the Center for Clinical immunology at Stanford; Associate Director, Institute of Immunity, Transplantation and ...
Loutit was the first to recognize 'secondary disease' in irradiated mice restored by the transplantation of foreign cells, and ... is fundamental to an understanding of the mechanism and repair of radiation injury and has important bearings on immunology and ... His candidature citation read: Distinguished for his experimental studies of tissue transplantation after lethal doses of ...
Beta thalassemia major can be treated by lifelong blood transfusions or bone marrow transplantation. According to a recent ... Parasite Immunology. 31 (5): 234-53. doi:10.1111/j.1365-3024.2009.01106.x. PMID 19388945. S2CID 23734166. Tishkoff SA, Williams ...
... was a British biologist who did significant research in the fields of reproductive immunology and organ transplantation. "He ... He continued to work on transplantation with Medawar, and in 1951 they both accepted positions at the University College London ... Brent, Leslie Baruch (25 November 2002). "Professor Rupert Billingham; Pioneer in the field of organ transplantation". The ...
Close more info about Kidney Transplantation: Transplant Immunology and Use of Immunosuppression ... Close more info about Kidney Transplantation: Transplant Immunology and Use of Immunosuppression ... Close more info about Kidney Transplantation: Transplant Immunology and Use of Immunosuppression ... Close more info about Kidney Transplantation: Transplant Immunology and Use of Immunosuppression ...
Immunology in Thoracic Transplantation answers are found in the Adult and Pediatric Cardiac powered by Unbound Medicine. ... "Immunology in Thoracic Transplantation." Adult and Pediatric Cardiac Surgery. STS Cardiothoracic Surgery E-Book, Chicago: ... Immunology in Thoracic Transplantation. In: Baumgartner WA, Jacobs JP, Darling GE, eds. Adult and Pediatric Cardiac Surgery. ... Immunology in Thoracic Transplantation is a topic covered in the Adult and Pediatric Cardiac. To view the entire topic, please ...
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. ... Renal transplantation across the ABO barrier: the Midwest Organ Bank experience  Hogan, L.S. (American Society for Clinical ...
... scholers and researcher share their experience in the firld of Immunology. ... The Confernece on Immunology is to be held on May 24-25, 2023 Vienna, Austria where scientists, ... Poster Competition is organized to encourage students and recent graduates to present their original research at Immunology ... Immunology. May 24-25, 2023 Vienna, Austria Next Generation Approach to Immunology for Clinical Advancement Submit Abstract ...
As such, transplantation outcomes depend vitally on the successful reconstruction of immune competence. Restoration of a normal ... Cytoreductive conditioning regimens used in the context of allogeneic hematopoietic cell transplantation (HCT) elicit deficits ... Animals, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, T-Lymphocytes, Thymus Gland, Transplantation ... As such, transplantation outcomes depend vitally on the successful reconstruction of immune competence. Restoration of a normal ...
Center for Immunology & Transplantation. Combining Biochemical, Biological, Pharmacological, Molecular, and Clinical Interests. ... Trends in Immunology. Well this is embarassing -- your RSS feed is empty. ...
Transplantation immunology. In: Abbas AK, Lichtman AH, Pillai S, eds. Cellular and Molecular Immunology. 10th ed. Philadelphia ... Tse G, Marson L. Immunology of graft rejection. In: Forsythe JLR, ed. Transplantation: A Companion to Specialist Surgical ... Transplantation immunobiology and immunosuppression. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston ...
Immunology, Autoimmunity, Inflammation & Transplantation. Immune system responses to pathogens and diseases. This group focuses ... Acute Kidney Injury and repair, Kidney transplantation, Tumour immunology. Mansour Haeryfar. We investigate innate-like and ... Acute Kidney Injury and repair, Kidney transplantation, Tumour immunology. Mansour Haeryfar. We investigate innate-like and ... Cancer immunology; Cancer treatment; DNA tumour viruses; Cancer gene regulation. This groups investigates the molecular ...
The immunology of bone and cartilage transplantation. Orthopedics. 1991 Sep. 14 (9):987-96. [QxMD MEDLINE Link]. ... Bone transplantation and human immunodeficiency virus. An estimate of risk of acquired immunodeficiency syndrome (AIDS). Clin ... Survival analysis of human meniscal transplantations. J Bone Joint Surg Br. 2002 Mar. 84 (2):227-31. [QxMD MEDLINE Link]. ... Survival of cells after intra-articular transplantation of fresh allografts of the patellar and anterior cruciate ligaments. ...
Liver Transplantation / immunology* * Prednisone / therapeutic use * Recurrence * Reoperation * Retrospective Studies * ...
Immunology and Transplantation, April 13 2012 Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects ... Pancreatic islet transplantation as a treatment for type 1 diabetes received a major impetus with the development of the ... If islet transplantation is to be made widely available and the current restricted selection criteria expanded, an alternate ... Porcine islet isolation and transplantation.. NICC were isolated from the pancreases of 1- to 3-day-old piglets and propagated ...
Transplantation/Immunology. *. Anastomotic Suturing Techniques and Their Association With Post-Lung Transplantation ...
Immunology invites the participants from all across the globe to take part in 4th International Conference on Immunology & ... To have an exposure globally at 4th International Conference on Immunology & Immunotherapy which will be held during May 09-10 ... Immunology And Immunotherapy. May 09-10, 2023 Zurich, Switzerland Part of Immune System towards Immunology and Immunotherapy ... Immunology And Immunotherapy Event Contact Desk. Conference Series LLC Ltd. 47 Churchfield Road, W3 6AY, London. ...
Palabras clave : Liver transplantation; Hepatitis C, chronic; Transplantation immunology. · texto en Español · Español ( pdf ) ... ALEGRIA Q, Sylvia et al. Chronic hepatitis and cirrhosis caused by C virus before and after liver transplantation. Rev. méd. ... Two years later, she was subjected to a liver transplantation. She maintained elevated viral loads with a normal pathological ... dying three years after transplantation (Rev Méd Chile 2004; 132: 479-84) ...
... learn why genetic relationship between donor and recipient is basic to all else in transplantation. ... Transplantation immunology is a field that is constantly changing and evolving, and provides a basis for innovative research, ... During the last half of the 20th century, incredible progress was made in transplantation immunology and medicine. However, ... Susan Smith, Site Editor and Program Director, Medscape Transplantation, Medscape, Inc.. Jean M. Goycoolea, MA Project ...
Stefanie Desmet, Microbiology, Immunology, and Transplantation, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, ...
UCL Institute of Immunity and Transplantation. UCL Institute of Immunity and Transplantation. Emma Morris Reader in Immunology ...
Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium ... European consensus conference on faecal microbiota transplantation in clinical practice. Gut 66, 569-580 (2017). ... Effects of fecal microbiota transplantation on composition in mice with CKD. Toxins https://doi.org/10.3390/toxins12120741 ( ...
... immunology/transplantation infectious disease, neurology; ophthalmology; patient education; pharmacoeconomics; public health ( ... General medicine, including allergy/immunology, critical care, diabetes, hematology/oncology, influenza, ophthalmology, ...
Hematopoietic stem cell transplantation. *Abnormal newborn screen. Appointments & referrals. Click to expand or collapse ... Get directions to Cook Children's Immunology at 1500 Cooper St. Fort Worth, TX ...
Pancreas and islet transplantation have been attractive therapeutic approaches; however, transplants containing insulin- ... Pancreas or islet transplantation have been attractive therapeutic approaches, however, transplants containing insulin- ... Keywords: type 1 diabetes, immunology, autoimmune diseases, transplantation immunology, tolerance induction, T cells, ... Reffet S, Thivolet C. Immunology of pancreatic islet transplantation. Diabetes Metab (2006) 32(5 Pt 2):523-6. doi:10.1016/S1262 ...
Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. ... International Liver Transplantation Society, American Association for the Study of Liver Diseases, and the American Society for ...
This article belongs to the Special Issue Personalized Medicine in Kidney Transplantation and Immunology). ... Physical Inactivity: A Modifiable Risk Factor for Morbidity and Mortality in Kidney Transplantation by Claudio Ponticelli ... This article belongs to the Special Issue Precision Medicine for Immunology and Immunogenetics). ...
Allergy, Immunology and Transplantation Research. Department of Health and Human Services. Agency: Department of Health and ...
Transplantation Immunology, Transplants, Perioperative Nursing, Operating Room Nursing, Postanesthesia Nursing, Anesthesiology ... Public Health, Health Management, Health Policy, Planning and Management, Clinical Medicine, Ethics, Clinical, Transplantation ... Pediatric Transplantation, Técnicas e Procedimentos de Laboratório, nçariançariançariança, riastóriastóriastóriastórias ...
Sample Decks: Immunology 1: Hypersensitivity + allergy, Immunology 2: Tolerance and Autoimmunity, Immunology 3: Transplantation ... Sample Decks: tumour immunology and immunotherapy of cancer, tumour immunology and immunotherapy of cancer, tumour immunology ... Sample Decks: Tumour immunology and immunotherapy of cancer , Transplantation , Hypersensitivity, allergy and inflammation ... Sample Decks: Tumour immunology and immunotherapy of cancer, Organ transplantation, Hypersensitivity and allergy ...
"Medawars legacy to cellular immunology and clinical transplantation: a commentary on Billingham, Brent and Medawar (1956) ... "The Birth of Transplantation Immunology: the Billingham--Medawar Experiments at Birmingham University and University College ... Immunology[edit]. Medawars first scientific research was on the effect of malt on the development of connective tissue cells ( ... "Cellular & Molecular Immunology. 11 (5): 405-406. doi:10.1038/cmi.2014.64. PMC 4197211. PMID 25066420.. ...
Nude and SCID mice, for example, are used in tissue transplantation and immunology studies. Produced by chance events, these ...
  • Pancreatic islet transplantation as a treatment for type 1 diabetes received a major impetus with the development of the Edmonton protocol and recent clinical trials demonstrating long-term insulin independence out beyond 5 years after transplantation ( 1 - 4 ), although encouraging this therapy will always be limited by the relatively small number of organ donors available for islet isolation. (diabetesjournals.org)
  • The second section of this review briefly describes the necessity for pancreas or islet transplantation to treat severe diabetic complications. (frontiersin.org)
  • Unawareness of severe hypoglycemia is a primary indicator for pancreas or islet transplantation and is often combined with kidney transplantation to treat renal failure. (frontiersin.org)
  • EPITA is established to provide a forum for those working in the field of pancreas and islet of Langerhans transplantation or any other alternative form of beta cell replacement in Europe, to exchange scientific information and views related primarily to providing the best service for patients in Europe requiring pancreas or islet transplantation. (esot.org)
  • The results of the trial show the feasibility and reproducibility of islet transplantation using the Edmonton Protocol and has promising implications for the future of treating type 1 diabetes," says NIH Director Elias A. Zerhouni, M.D. (nih.gov)
  • Dr. Shapiro and the ITN research team have improved our understanding of the potential of islet transplantation for certain patients with Type 1 diabetes," says NIAID Director Anthony S. Fauci, M.D. "Ongoing studies will further define the clinical utility of this approach. (nih.gov)
  • This really shows that islet transplantation can be tremendously successful in protecting against hypoglycemic unawareness," says Dr. Shapiro. (nih.gov)
  • I had my appetite whetted for islet cell transplantation way back in the 1970s, when I did my research training in Denver, Colorado," he told me when I called him at his home in New Zealand from mine in Boulder, Colorado. (mendosa.com)
  • Even now the clinical trial that Michael Helyer volunteered for is only one of four published human trials of pig islet transplantation, according to Dr. David K.C. Cooper of the Thomas E. Starzl Transplantation Institute of the University of Pittsburgh Medical Center. (mendosa.com)
  • She led the development of the King's insulin pump programme and with the King's Liver Transplant Unit and Paediatric Hepatology, started a human islet isolation programme which formed the basis of the first reimbursed program of islet transplantation for hypoglycemia prevention. (insulin100.com)
  • In this article we will discuss about top and best books for Medical Microbiology and Immunology. (microbiologynote.com)
  • Learn all the microbiology and basic immunology concepts you need to know for your courses and exams. (microbiologynote.com)
  • Cytoreductive conditioning regimens used in the context of allogeneic hematopoietic cell transplantation (HCT) elicit deficits in innate and adaptive immunity, which predispose patients to infections. (ox.ac.uk)
  • This is a multi-center prospective rater-masked (blinded) randomized controlled trial of 156 participants, comparing the treatment strategy of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) to the treatment strategy of Best Available Therapy (BAT) for treatment-resistant relapsing multiple sclerosis ( MS ). Participants will be randomized at a 1 to 1 (1:1) ratio. (clinicaltrials.gov)
  • This study will compare high dose immunosuppression followed by autologous hematopoietic stem cell transplantation (AHSCT) to best available therapy (BAT) in the treatment of relapsing MS. (clinicaltrials.gov)
  • High dose immunosuppression followed by autologous hematopoietic stem cell transplantation (AHSCT) has been shown to help relapsing MS in cases where medicines did not work. (clinicaltrials.gov)
  • HLA-DRB3/4/5 Matching Improves Outcome of Unrelated Hematopoietic Stem Cell Transplantation. (cdc.gov)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • While this diversity protects us from pathogens, it also provides a large number of immune targets after organ transplantation. (renalandurologynews.com)
  • In its evolution as a stalwart defense against microbes, the human immune system has developed a profound ability to differentiate self from nonself, presenting the major barrier to the long-term success of organ transplantation. (sts.org)
  • This all-important property of immune responsiveness is also responsible for the major physiologic threat to organ transplantation -- rejection. (medscape.com)
  • Cite this: Immunologic Aspects of Organ Transplantation - Medscape - Jun 01, 2002. (medscape.com)
  • Induction of immunologic tolerance has been achieved and studied in numerous laboratory animal models, but it remains an elusive goal in clinical organ transplantation and in the management of autoimmune disease in humans. (medscape.com)
  • This became the foundation of tissue and organ transplantation. (wikipedia.org)
  • The Young Professionals in Transplantation (YPT) is the Network for Junior Transplant professionals of ESOT, representing all young transplant clinicians and scientists who are beginning a career in transplantation and organ donation. (esot.org)
  • The mission of ECTORS is to provide a forum for discussing and stimulating novel developments in the fields of cellular therapies in organ transplantation, organ regeneration and generation of new organs from stem cells and biomaterials. (esot.org)
  • EDTCO aims to support health care professionals to provide clinically effective programmes on organ and tissue donation, procurement and transplantation. (esot.org)
  • organ transplantation. (edu.au)
  • Organ and tissue transplantation in the European union : management of difficulties and health risks linked to donors / edited by Yvon Englert. (who.int)
  • Organ donation for transplantation : the Spanish model / edited by Rafael Matesanz and Blanca Miranda. (who.int)
  • Legal and ethical aspects of organ transplantation / David Price. (who.int)
  • Equity and utility will be discussed for each organ specifically with specialized tracks, as well as multi-organ transplantation. (healthytransplant.com)
  • The National Eye Institute (NEI) seeks research co-development or licensees for making research- or clinical-grade preservation solutions for cold-sensitive organ transplantation or protection of brain injury or trauma during surgery. (cancer.gov)
  • Follow up was 14±4 and 17±5 months respectively and included protocol kidney biopsies at 3 and 12 months post-transplantation. (northwestern.edu)
  • It has seven sub-specialty clinical programs that includes the Glomerulonephritis and Renal Vasculitis, Chronic Kidney Disease, Haemodialysis, Peritoneal Dialysis, Critical Care Nephrology, Renal Transplantation and Interventional Nephrology Program. (sgh.com.sg)
  • IMSEAR at SEARO: Flow cytometric crossmatch for kidney transplantation. (who.int)
  • Koktathong K, Vejbaesya S, Bejrachandra S, Pattanapanyasat K. Flow cytometric crossmatch for kidney transplantation. (who.int)
  • In conclusion, the result of FCXM is clear and this method is more sensitive than NIH- and AHG method FCXM should be used together with the NIH- and AHG method for kidney transplantation. (who.int)
  • ASt/AJT Journal Club on "Simultaneous pancreas-kidney transplantation in Caucasian versus African American patients. (healthytransplant.com)
  • This live stream is endorsed by the ERA , an Association that promotes the advancement of medical science by promoting fundamental and clinical advances in the field of nephrology, dialysis, renal transplantation, hypertension, and related subjects. (rsm.ac.uk)
  • Thymic T-cell development in allogeneic stem cell transplantation. (ox.ac.uk)
  • Approximately two thirds of patients (68%) underwent allogeneic stem cell transplantation and 31% underwent autologous stem cell transplantation. (medscape.com)
  • Combinations of anti-LFA-1, everolimus, anti-CD40 ligand, and allogeneic bone marrow induce central transplantation tolerance through hemopoietic chimerism, including protection from chronic heart allograft rejection. (novartis.com)
  • Central transplantation tolerance through hemopoietic chimerism initially requires inhibition of allogeneic stem cell or bone marrow (BM) rejection, as previously achieved in murine models by combinations of T cell costimulation blockade. (novartis.com)
  • Bortezomib Maintenance After Allogeneic Transplantation in Newly Diagnosed Myeloma Patients Results in Decreased Incidence and Severity of Chronic GVHD. (iric.ca)
  • Frontiers in immunology 2022 13 944442. (cdc.gov)
  • Journal of Immunology (Baltimore, Md. : 1950), 173 (11). (novartis.com)
  • The Egyptian journal of immunology / Egyptian Association of Immunologists 2005 12 (2): 21-8. (cdc.gov)
  • Central-European journal of immunology 2016 41 (3): 255-259. (cdc.gov)
  • European Journal of Immunology. (wustl.edu)
  • The research has demonstrated proof-of-principle safety and efficacy of these cells in a variety of indications covering cardiovascular, eye disease, orthopedic and bone marrow transplantation. (ny.gov)
  • However, significant issues have yet to be overcome in man's quest for transplantation without immunosuppression. (medscape.com)
  • Van Den Berghe L. Introduction to Transplant Immunology and Immunosuppression . (medscape.com)
  • Calcineurin inhibitors (CNI), the cornerstone of immunosuppression after transplantation are implicated in nephrotoxicity and allograft dysfunction. (northwestern.edu)
  • This requires an understanding of basic immunology, the mechanism of action and side effects of immunosuppressive medications, and a thorough immunologic risk assessment. (renalandurologynews.com)
  • NIAID also supports research on basic immunology, transplantation and immune-related disorders, including autoimmune diseases, asthma and allergies. (eurekalert.org)
  • There was also a significant reduction in morbidity and mortality among the patients who received defibrotide prophylactically, compared with those who received defibrotide for treatment," said lead study author Selim Corbacioglu, MD, assistant professor in the Department of Hematology, Oncology, Immunology, and Stem Cell Transplantation at the University of Ulm in Germany. (medscape.com)
  • VOD is one of the most frequently encountered serious complications associated with stem cell transplantation. (medscape.com)
  • In the current study, the largest-ever international multicenter trial of high-risk pediatric patients undergoing stem cell transplantation, Dr. Corbacioglu and colleagues assessed the safety and efficacy of defibrotide for the prevention of VOD. (medscape.com)
  • His current experimental research at the Thomas E. Starzl Transplantation Institute addresses the role of local immunotherapy in targeting and minimizing skin immunogenicity and induction of tolerance after CTA. (upmc.com)
  • Immunologic aspects of transplantation provide an important foundation for understanding how normal host defense mechanisms are triggered in response to transplanted organs. (medscape.com)
  • Two years later, she was subjected to a liver transplantation. (scielo.cl)
  • She maintained elevated viral loads with a normal pathological study of the liver until 22 months after transplantation. (scielo.cl)
  • Its membership represents the expertise on liver and intestinal transplantation in Europe. (esot.org)
  • Genetic factors underlying tacrolimus intolerance after liver transplantation. (cdc.gov)
  • Frontiers in immunology 2021 12 12 771449. (cdc.gov)
  • My research interests are focused on manipulating the immune system with a view to improving outcomes after transplantation.Together with Dr Paul Harden and Professor Peter Friend, I am currently investigating regulatory T cell (Treg) therapy in renal transplantation in the Phase IIb TWO Study. (esot.org)
  • Scientists are able to generate pancreatic cells from stem cells in the lab, and they can be transplanted to someone who has lost pancreatic function, but they'll be reattacked by the immune system," says Juan-Carlos Zúñiga-Pflücker , senior scientist at Sunnybrook Research Institute and professor of immunology in the Temerty Faculty of Medicine. (utoronto.ca)
  • Today, scientists are still working to fully answer this question and research efforts have formed the foundations of the field of reproductive immunology, which focuses on developing a deeper understanding of how the maternal immune system behaves during pregnancy. (azolifesciences.com)
  • Due to the incredibly complex nature of the immune system in combination with competing conceptual models among immunologists, the field of reproductive immunology has developed to become confusing and difficult to follow (even for clinicians and scientists in the field). (azolifesciences.com)
  • The IRM is excited to announce that we are partnering with the Institute for Immunology (IFI) for our fall 2021 symposium, Stem Cells & the Immune System: At the Crossroads of Regeneration . (upenn.edu)
  • He is a founding member of the American Society of Reconstructive Transplant Surgery and a member of the American Society of Reconstructive Microsurgery, the American Society of Surgery of the Hand, the American Society of Transplantation, the Transplantation Society, the Plastic Surgery Research Council and the Kleinert Society. (upmc.com)
  • He had graduate training in Immunology and malaria with Dr. Paul-Henri Lambert at the World Health Organization, Geneva, Switzerland from 1978-79, and post-doctoral training in transplantation biology with E. Donnell Thomas and John Hansen at the Fred Hutchinson Cancer Research Center in Seattle from 1983 - 1986. (upenn.edu)
  • Nonetheless, immune tolerance remains the holy grail of transplantation immunology and clinical transplantation. (medscape.com)
  • STAT4 gene polymorphism in patients after renal allograft transplantation. (cdc.gov)
  • [ 3 ] Seemingly impossible without genetic identity, the field of transplantation was left silent for another 20 years. (medscape.com)
  • VCA has opened a new era in the field of transplantation, reconstructive and restorative surgery. (esot.org)
  • Although treatment of acute rejection (AR) is effective, AMR remains difficult to treat, and little can be offered to mitigate chronic rejection, limiting the long-term effectiveness of thoracic transplantation to treat end-stage heart or lung disease. (sts.org)
  • Despite a troubled economic and political past, a tradition of fundamental research in immunology and infectious diseases has been fostered in Argentina, Brazil and Chile, as well as in other South American countries. (nature.com)
  • Though the research could be applied broadly across regenerative medicine therapies, type 1 diabetes makes an ideal test case, says Zúñiga-Pflücker, who is also chair of the department of immunology. (utoronto.ca)
  • While there have been disappointing research findings, it is still valuable to continue exploring this area of reproductive immunology to establish effective preventative therapies for those at risk of miscarriage. (azolifesciences.com)
  • Transplantation tolerance could eliminate many of the adverse events associated with immunosuppressive agents. (medscape.com)
  • In the last few decades, doctors have been able to treat Type 1 diabetes with pancreas transplantation. (nih.gov)
  • Many people with diabetes who have taken daily insulin injections for years have achieved total insulin independence after pancreas transplantation - often for years after the transplant. (nih.gov)
  • As such, transplantation outcomes depend vitally on the successful reconstruction of immune competence. (ox.ac.uk)
  • Clinical Immunology and Immunopathology, 18 (1). (pitt.edu)
  • Though both responses (innate and adaptive) are important in transplantation, the majority of treatment modalities in transplantation are directed against the adaptive immune response. (renalandurologynews.com)
  • Research across UHN's five research institutes spans the full spectrum of diseases and disciplines, including cancer, cardiovascular sciences, transplantation, neural and sensory sciences, musculoskeletal health, rehabilitation sciences, and community and population health. (uhntrainees.ca)
  • I am a researcher based in the Transplantation Research Immunology Group (TRIG) and the John Radcliffe Hospital. (esot.org)
  • It means "the transplantation of organs, tissues, or cells from one species to another," especially humans. (mendosa.com)
  • Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection. (bvsalud.org)
  • The two primary avenues for beta cell replacement are transplantation of cadaveric islets or induced pluripotent stem cell (iPS)-derived beta cells. (frontiersin.org)
  • Transplantation immunology is a field that is constantly changing and evolving, and provides a basis for innovative research, education, and practice. (medscape.com)
  • The Basic Science Committee promotes scientific issues and transplantation research within ESOT. (esot.org)
  • In this commentary we summarize the origin, present status and future challenges facing immunology research in Argentina, Brazil and Chile. (nature.com)
  • Dr. Gorantla's academic expertise and clinical research interests include clinical hand transplantation and novel immunomodulatory protocols directed at reducing long-term risk due to immunosuppressive drugs after CTA. (upmc.com)
  • In recent years, research into the possible causes of unexpected infertility has focused on exploring the role of immunology in reproductive failure. (azolifesciences.com)
  • Dr Candice Roufosse, NIHR Imperial BRC Immunology Theme Principal Investigator and Senior Clinical Lecturer at the Centre for Inflammatory Diseases, was successful in receiving support to undertake this workshop through the NIHR Imperial BRC Patient Experience Research Centre (PERC) PPI Grant Scheme. (nihr.ac.uk)
  • The first international, multicenter trial of the Edmonton Protocol - a standardized approach to the transplantation of insulin-producing islets - demonstrates that this may be an appropriate therapy that can dramatically benefit certain patients with severe complications of Type 1 diabetes mellitus. (nih.gov)