A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.
The transference of a part of or an entire liver from one human or animal to another.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The transference of a kidney from one human or animal to another.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
The transference of a heart from one human or animal to another.
Transplantation of an individual's own tissue from one site to another site.
The transference of either one or both of the lungs from one human or animal to another.
Transference of an organ between individuals of the same species or between individuals of different species.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
The transference of a pancreas from one human or animal to another.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Elements of limited time intervals, contributing to particular results or situations.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The return of a sign, symptom, or disease after a remission.
Prospective patient listings for appointments or treatments.
Transplantation between animals of different species.
The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.
Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Partial or total replacement of the CORNEA from one human or animal to another.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Theoretical representations that simulate the behavior or activity of immune system, processes, or phenomena. They include the use of mathematical equations, computers, and other electrical equipment.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A dead body, usually a human body.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
Time period from 1901 through 2000 of the common era.
Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
Pathological processes of the LIVER.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Freedom of equipment from actual or potential hazards.
The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Time period from 2001 through 2100 of the common era.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Immunologic techniques involved in diagnosis.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
Techniques used to demonstrate or measure an immune response, and to identify or measure antigens using antibodies.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Therapeutic act or process that initiates a response to a complete or partial remission level.
The transference of a complete HAND, as a composite of many tissue types, from one individual to another.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
The period following a surgical operation.
Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Disease having a short and relatively severe course.
Progenitor cells from which all blood cells derive.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.
The biochemical and electrophysiological interactions between the NERVOUS SYSTEM and IMMUNE SYSTEM.
Protection from an infectious disease agent that is mediated by B- and T- LYMPHOCYTES following exposure to specific antigen, and characterized by IMMUNOLOGIC MEMORY. It can result from either previous infection with that agent or vaccination (IMMUNITY, ACTIVE), or transfer of antibody or lymphocytes from an immune donor (IMMUNIZATION, PASSIVE).
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Antibodies produced by a single clone of cells.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Immunological rejection of leukemia cells following bone marrow transplantation.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A general term for diseases produced by viruses.
Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Substances that are recognized by the immune system and induce an immune reaction.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
An encapsulated lymphatic organ through which venous blood filters.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Hereditary inflammation conditions, characterized by recurrent episodes of systemic inflammation. Common symptoms include recurrent fever, rash, arthritis, fatigue, and secondary AMYLOIDOSIS. Hereditary autoinflammatory diseases are associated with mutations in genes involved in regulation of normal inflammatory process and are not caused by AUTOANTIBODIES, or antigen specific T-LYMPHOCYTES.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Immunological rejection of tumor tissue/cells following bone marrow transplantation.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
Time period from 1801 through 1900 of the common era.
Venoms from animals of the phylum Arthropoda. Those most investigated are from scorpions and spiders of the class Arachnidae and from ant, bee, and wasp families of the Insecta order Hymenoptera. The venoms contain protein toxins, enzymes, and other bioactive substances and may be lethal to man.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Providers of tissues for transplant to non-related individuals.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Tumors or cancer of the LIVER.
Excision of all or part of the liver. (Dorland, 28th ed)
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
Disorders of the blood and blood forming tissues.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Bites and stings inflicted by insects.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
The mucous lining of the LARYNX, consisting of various types of epithelial cells ranging from stratified squamous EPITHELIUM in the upper larynx to ciliated columnar epithelium in the rest of the larynx, mucous GOBLET CELLS, and glands containing both mucous and serous cells.

Donor MHC and adhesion molecules in transplant arteriosclerosis. (1/919)

Transplant-associated arteriosclerosis remains an obstacle to long-term graft survival. To determine the contribution to transplant arteriosclerosis of MHC and adhesion molecules from cells of the donor vasculature, we allografted carotid artery loops from six mutant mouse strains into immunocompetent CBA/CaJ recipients. The donor mice were deficient in either MHC I molecules or MHC II molecules, both MHC I and MHC II molecules, the adhesion molecule P-selectin, intercellular adhesion molecule (ICAM)-1, or both P-selectin and ICAM-1. Donor arteries in which ICAM-1, MHC II, or both MHC I and MHC II were absent showed reductions in neointima formation of 52%, 33%, and 38%, respectively, due primarily to a reduction in smooth muscle cell (SMC) accumulation. In P-selectin-deficient donor arteries, neointima formation did not differ from that in controls. In donor arteries lacking both P-selectin and ICAM-1, the size of the neointima was similar to that in those lacking ICAM-1 alone. In contrast, neointima formation increased by 52% in MHC I-deficient donor arteries. The number of CD4-positive T cells increased by 2.8-fold in MHC I-deficient arteries, and that of alpha-actin-positive SMCs by twofold. These observations indicate that ICAM-1 and MHC II molecules expressed in the donor vessel wall may promote transplant-associated arteriosclerosis. MHC I molecules expressed in the donor may have a protective effect.  (+info)

Effective treatment of autoimmune disease and progressive renal disease by mixed bone-marrow transplantation that establishes a stable mixed chimerism in BXSB recipient mice. (2/919)

Male BXSB mice spontaneously develop autoimmune disease with features similar to systemic lupus erythematosus. To determine whether this autoimmune disease can be treated as well as prevented by bone-marrow transplantation (BMT) and, at the same time, whether the immunity functions of lethally irradiated recipients can be reconstituted fully, male BXSB mice were engrafted with mixed T cell-depleted marrow (TCDM) both from fully allogeneic autoimmune-resistant BALB/c mice and from syngeneic autoimmune-prone BXSB mice, after the onset of autoimmune disease in the recipient mice. BMT with mixed TCDM from both resistant and susceptible strains of mice (mixed BMT) established stable mixed chimerism, prolonged the median life span, and arrested development of glomerulonephritis in BXSB mice. BMT with mixed TCDM also reduced the formation of anti-DNA antibodies that are observed typically in male mice of this strain. Furthermore, mixed BMT reconstituted the primary antibody production in BXSB recipients impressively. These findings indicate that transplantation of allogeneic autoimmune-resistant TCDM plus syngeneic autoimmune-prone TCDM into lethally irradiated BXSB mice can be used to treat autoimmune and renal disease in this strain of mice. In addition, this dual bone-marrow transplantation reconstitutes the immunity functions and avoids the immunodeficiencies that occur regularly in fully allogeneic chimeras after total body irradiation. This report describes an effective treatment of progressive renal disease and autoimmunity by establishing a stable mixed chimerism of TCDM transplantation from allogeneic autoimmune-resistant BALB/c mice plus syngeneic autoimmune-prone BXSB mice into BXSB mice.  (+info)

Immune reconstitution after bone marrow transplantation for combined immunodeficiencies: down-modulation of Bcl-2 and high expression of CD95/Fas account for increased susceptibility to spontaneous and activation-induced lymphocyte cell death. (3/919)

We have studied the regeneration of T cell subsets and function after BMT in 21 children affected by combined immunodeficiency after BMT. In the first months, the striking predominance of CD4+ cells displayed the primed CD45R0+ phenotype and a high number of activated (HLA-DR+) T cells were observed. Regeneration of naive CD4+CD45RA+ cells correlated with the recovery of proliferative responses to mitogens (r = 0.64, P<0.001). Peripheral blood lymphocytes circulating after BMT undergo an increased process of in vitro cell death, resulting from two mechanisms: spontaneous apoptosis (SA), a consequence of defective production of IL-2 and down-regulation of Bcl-2 (P = 0.02 vs. healthy controls), and high susceptibility to activation-induced cell death (AICD) after restimulation with mitogens. In accordance with the role of CD95/Fas in this latter process, we have observed a high level of CD95 expression (P<0.001 vs. healthy controls), correlated with AICD (P<0.001) but not with SA, and decreasing with time after BMT (P<0.001). Both SA and AICD levels correlated with the presence of activated T cells and decreased with the progressive recovery of T cell proliferative response. Therefore, the lymphocyte hyperactivated status might explain their susceptibility to apoptosis and contribute to the genesis of immunodeficiency that follows BMT.  (+info)

Increasing mixed haematopoietic chimaerism after BMT with total depletion of CD4+ and partial depletion of CD8+ lymphocytes is associated with a higher incidence of relapse. (4/919)

In this study we analysed the incidence and clinical impact of the persistence of host haemopoiesis (mixed chimaerism, MC) after allogeneic BMT in 35 consecutive patients with haematologic malignancies using a total CD4+ cell-depleted graft with an adjusted dose of CD8+ cells (1x10(8)/kg). Chimaerism was assessed by PCR amplification of VNTRs in 30 evaluable patients: 19 non-CML and 11 CML cases which were also evaluated for the BCR-ABL transcript by RT-PCR. All but one had complete engraftment with a donor profile early post-BMT. At the end of the study period, 12 of 30 patients displayed MC (40%). The overall disease-free survival for MC patients was clearly unfavourable when compared to those who exhibited a donor profile (24.7% vs. 100%, P = 0.005). However, we found that only two of five patients with MC in the non-CML group relapsed, whereas a clear correlation could be made between MC and relapse in CML (seven showed MC, preceding cytogenetic or haematological relapse in six of them, which displayed a prior BCR-ABL mRNA positivity). In addition, a quantitative-PCR approach enabled us to demonstrate that increasing amounts of MC are invariably associated with subsequent relapse, whereas a low stable level of host or complete donor haemopoiesis is consistent with clinical complete remission. Although these results suggest that the clinical impact of MC may depend on the underlying disease, it is compatible with the concept that the graft-versus-leukaemia effect against CML is mainly exerted by donor CD4+ lymphocytes. Elimination of this cellular subset may be responsible for the inability of the graft to prevent a progressive increase in the tumor cell burden.  (+info)

Immune reconstitution following allogeneic peripheral blood stem cell transplants. (5/919)

Growth factor-mobilized peripheral blood stem cells (PBSCs) engraft rapidly in myeloablated recipients compared to conventional BM, but this procedure also mobilizes mature lymphocytes and monocytes which can impact immune reconstitution and GVHD. Hence, we serially evaluated immune reconstitution and cytokine expression in PBSCT recipients in the first year. Engraftment of neutrophils and monocytes stabilized early but NK cells, B cells and CD4+ T cell numbers were significantly (P < 0.05) low with persistently reversed CD4:CD8 ratios. NK function remained low throughout the first year. The quantitative decrease in CD4+ T cells resulted in significantly decreased proliferation in response to mitogens and alloHLA antigens. Yet, a qualitative analysis of T cell function measured by Ca++ influx after T cell activation with antiCD3 as well as T-dependent polyclonal Ig secretion by mitogen-stimulated B cells was preserved even early post transplant. TNF alpha mRNA was detected in almost all recipients in the first year. IL-10 mRNA was detected in 77%, IL-2 in 22% and IFN gamma in 44% of recipients in the first 6 months. Only 30% expressed IL-10 in the second 6 months post transplant while expression of IL-2 and IFN gamma was detected in 38% and 46% respectively. Thirty-seven percent of PBSCT recipients developed grades II-IV acute GVHD but 72% went on to develop chronic extensive GVHD at a median of 120 days. Sixty-two percent developed CMV viremia and 5.4% developed overt CMV disease in the first year post PBSCT. Lymphocyte engraftment is quantitatively delayed but CD4 functions are preserved while NK numbers and function are compromised post PBSCT. IL-10 expression decreases after the first 6 months post transplant while TNF alpha is continually expressed. The balance between quantitative lymphocyte reconstitution and qualitative lymphocyte functions as well as changes in lymphokine patterns may influence infection and GVHD and thus the clinical outcome post PBSCT.  (+info)

Effective T cell regeneration following high-dose chemotherapy rescued with CD34+ cell enriched peripheral blood progenitor cells in children. (6/919)

The ex vivo enrichment for the CD34+ cell fraction of PBPC, while it retains the capacity to restore haematopoiesis and potentially reduces a contamination by tumour cells, implements a depletion of T cells. To test whether such a setting adversely affects T cell reconstitution, we monitored T cells in four paediatric patients after CD34+ selected PBPC transplantation. The dose of CD34+ cells, which were enriched to 74%, median, was 7.1 x 10(6)/kg, median, that of T cells was 0.071 x 10(6)/kg, median. The patients were homogenous with respect to features with a potential to effect T cell reconstitution (low median age, (35 years); stage IV malignant tumours in first CR, uncomplicated post-treatment course). The results of sequential FACS analyses showed that by 9 months after treatment all four patients had recovered (1) a normal T cell count (CD3+ cells 1434/microl, median); (2) a normal CD4+ cell count (816/microl, median), while CD8+ cells were recovered (>330/microl) already by 3 months; (3) a normal CD4/CD8 ratio (1.8, median), as a result of an augmented growth of CD4+ cells between 3 and 6 months (increase of CD4+ cells 4.9-fold, median, CD8+ cells 1.1-fold, median). Expansion of cells with a CD45RA+ phenotype (thymus-derived T cells) predominated; from 3 to 6 months the increase of CD4+/CD45RA+ T cells was 130-fold, that of CD4+/CD45RO+ cells was 1.7-fold; CD8+/CD45RA+ cells increased 9-fold, CD8+/CD45RO+ cells increased 2.1-fold, indicating effective thymopoiesis. The findings demonstrate that in paediatric patients the setting of HD-CTX rescued with autologous CD34+ selected PBPC per se is not predictive of an impaired T cell recovery. High thymic activity may be a key factor for the rapid restoration of T cells.  (+info)

Mice with Th2-biased immune systems accept orthotopic corneal allografts placed in "high risk" eyes. (7/919)

CD4+ T cells of the Th1 type play a central role in acute rejection of solid tissue grafts, including orthotopic corneal allografts. Th1 cells, which mediate delayed hypersensitivity, are the polar opposites of CD4+ Th2 cells, and the latter cells cross-regulate Th1 cells through the unique pattern of cytokines they secrete. As such, Th2 cells may have a useful role to play in preventing rejection of corneal allografts. To test this possibility, the immune systems of adult mice were biased toward Th2 responses by immunization with keyhole limpet hemocyanin plus IFA. When immunized subsequently with either OVA or allogeneic corneal tissue, these mice acquired Ag-specific primed T cells of the Th2 type. More important, allogeneic corneas grafted into neovascularized eyes of Th2-biased mice experienced significantly enhanced survival. To demonstrate that enhanced survival was promoted by donor-specific Th2 cells, lymphoid cells from keyhole limpet hemocyanin-immune mice bearing healthy corneal allografts suppressed orthotopic corneal allograft rejection when adoptively transferred into naive, syngeneic recipients. We conclude that acceptance of corneal allografts in neovascularized mouse eyes can be significantly enhanced by biasing the recipient immune system toward Th2 responses.  (+info)

Chronic rejection of mouse kidney allografts. (8/919)

BACKGROUND: Chronic renal allograft rejection is the leading cause of late graft failure. However, its pathogenesis has not been defined. METHODS: To explore the pathogenesis of chronic rejection, we studied a mouse model of kidney transplantation and examined the effects of altering the expression of donor major histocompatibility complex (MHC) antigens on the development of chronic rejection. RESULTS: We found that long-surviving mouse kidney allografts develop pathological abnormalities that resemble chronic rejection in humans. Furthermore, the absence of MHC class I or class II antigens did not prevent the loss of graft function nor alter the pathological characteristics of chronic rejection. Expression of transforming growth factor-beta (TGF-beta), a pleiotropic cytokine suggested to play a role in chronic rejection, was markedly enhanced in control allografts compared with isografts. However, TGF-beta up-regulation was significantly blunted in MHC-deficient grafts. Nonetheless, these differences in TGF-beta expression did not affect the character of chronic rejection, including intrarenal accumulation of collagens. CONCLUSIONS: Reduced expression of either class I or II direct allorecognition pathways is insufficient to prevent the development of chronic rejection, despite a reduction in the levels of TGF-beta expressed in the allograft. This suggests that the severity of chronic rejection is independent of the level of MHC disparity between donor and recipient and the level of TGF-beta expression within the allograft.  (+info)

The thymus, spleen, and lymph nodes were studied in runt disease induced by a graft of intravenously injected homologous splenic cells into newborn rats and mice. Adult Long-Evans cells (70 x 106) were injected into Sprague-Dawley rats. Adult DBA cells (7 x 106) were injected into C57BL/6 mice. Runted rats were sacrificed at 14 to 28 days of age; mice at 10 to 20 days. The thymic cortex is depleted of small lymphocytes. Those remaining are severely damaged and phagocytized. Evidence of damage includes swelling of mitochondria, myelin figure formation, margination of chromatin, and sharp angulation in nuclear contour. Large numbers of macrophages are present. Epithelial-reticular cells which envelop small cortical blood vessels are often retracted, with the result that the most peripheral layer in the thymic-blood barrier suffers abnormally large gaps. Lymphocytes of the periarterial lymphatic sheaths of spleen and of the cortex of lymph nodes are reduced in number and damaged. Vast numbers of ...
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Summary Simian virus 40 (SV40)-transformed cells express the SV40-specific tumour transplantation antigen (TSTA) on the cell surface and the SV40-coded tumour antigen in their nuclei. TSTA is defined by SV40-specific transplantation immunity, whereas T-antigen (T-Ag) can be detected serologically by indirect immunofluorescence. Both antigens, however, are derived from the A gene of SV40. We therefore analysed SV40-transformed cells for the presence of serologically detectable T-Ag-related molecules. Such antigens could not be detected on the surface of living SV40-transformed cells in monolayers. However, after a short formaldehyde fixation it was possible to stain the cell surfaces of SV40-transformed cells with sera from rabbits immunized with purified SDS-denatured T-Ag, but not with sera from hamsters bearing SV40-induced tumours. T-Ag-related antigens could be detected with both types of antisera by applying a more sensitive 125I-protein A assay. The T-Ag specificity of the binding of hamster SV40
As we want all the information on Hypertension Solutions to be as accurate as possible we pass the responsibility of researching and writing the articles on Hypertension Solutions to real Doctors and the name of the Doctor that has researched and written the article will be at the bottom of each article.. ...
T Regulatory cells (Treg) play an important role in the induction and maintenance of immunological tolerance to self and alloantigens. Recent findings in experimental transplant models have demonstrated that Treg can control acute and delayed allograft rejection. Preclinical attempts to use Treg as a cellular therapy have been successfully undertaken demonstrating the safety and feasibility of such treatment, suggesting that they have therapeutic potential. © 2011 by Elsevier Inc. All rights reserved.
Heart Transplantation - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
Heart Transplantation - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
Steinmetz, M; Winoto, A; Minard, K; and Hood, L, Clusters of genes encoding mouse transplantation antigens. (1982). Subject Strain Bibliography 1982. 3024 ...
TY - JOUR. T1 - Tissue-specific, peptide-binding transplantation antigens. T2 - Lessons from the Qa-2 system. AU - Stroynowski, Iwona. PY - 1995. Y1 - 1995. UR - http://www.scopus.com/inward/record.url?scp=0028991945&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0028991945&partnerID=8YFLogxK. M3 - Article. SP - 90. EP - 108. JO - Immunological Reviews. JF - Immunological Reviews. SN - 0105-2896. IS - 147. ER - ...
Graft‐versus‐host disease (GVHD) represents a special situation in transplantation immunology in which immunocompetent donor cells are engrafted into recipients that are incapable of rejecting them due to tolerance, immaturity, or radiation‐ or chemotherapy‐induced immune deficiency
Dr Sebastiaan Heidt is an associate professor working in the laboratory of Transplantation Immunology of Leiden University Medical Center, the Netherlands. After obtaining his PhD at Leiden University on the characterization of B cells in ...
Définitions de Diagnostic_immunology, synonymes, antonymes, dérivés de Diagnostic_immunology, dictionnaire analogique de Diagnostic_immunology (anglais)
Walzer T; Chiossone L; Chaix J; Calver A; Carozzo C; Garrigue-Antar L; Jacques Y; Baratin M; Tomasello E; Vivier E; Nature Immunology, 2007, vol. 8, issue 12, p 1337, ISSN 15292916. ISBN 15292916. ...
Since the first successful transplant of a kidney between identical twins in 1955, transplantation has progressed from being an experimental procedure to a routine clinical therapy offering immense benefits for patients with organ failure, but the survival of transplanted organs remains limited by the bodys immune responses, and many of the complications of transplantation result from the crude nature of our attempts to suppress these....
Tsakraklides, E; Smith, C; Kersey, J H.; and Good, R A., Transplantation antigens (h-2) on virally and chemically transformed balb/3t3 fibroblasts in culture. (1974). Subject Strain Bibliography 1974. 1195 ...
Browse from thousands of Immunology questions and answers (Q&A). Become a part of our community of millions and ask any question that you do not find in our Immunology Q&A library.
The cross-reactivity between the tumor-specific antigen of ascites mouse mammary Tumor MM102 and that of primary spontaneous mammary carcinomas (p-SMC) was studied with the absorption test of specific antiserum and the transplantation immunity test. Anti-MM102 antiserum produced in the syngeneic host (C3H/He mouse) was completely absorbed by established mammary tumor virus (MTV)-induced cell lines derived from various strains of mice but was not absorbed by p-SMC. C3H/He mice which acquired a heightened resistance against transplantation of MM102 showed a low degree of induced resistance to p-SMC. C3H/He mice immunized with p-SMC acquired a heightened resistance against not only p-SMC but also MM102. These results led to the conclusion that some common tumor-specific transplantation antigen exists for MM102 and p-SMC, although the amount of the common antigen was markedly less in p-SMC than in MM102. No differences between MTV-infected C3H/He mice and MTV-free C3Hf mice were observed in the ...
In the context of solid organ transplantation, the exact interactions between the innate and adaptive alloimmune response have not yet been fully explored. In this transplant setting, natural killer (NK) cells have emerged as a particular focus of interest because of their ability to distinguish all …
Transplantation immunology, accommodation, immunologic properties and genomic stability of stem cells, genetic basis of cell transformation and oncogenesis. ...
Read Comparison of cell counting methods from the Society for Mucosal Immunology, an organization dedicated to research in the field of mucosal immunology.
Liquichek Immunology Control,Liquichek Immunology Control is a trilevel, liquid, comprehensive serum protein control with assayed values for a wide number of methods.,medicine,medical supply,medical supplies,medical product
Activity of the hair follicle is cyclic, periods of hair-growth alternating with periods of quiescence during which the dead hair is retained as a club. In the rat, hair-growth occurs in a series of waves which start ventrally and pass over the flanks to the back (Dry, 1926; Butcher, 1934; Johnson, 1958a).. The object of our work was to find out how far such activity is dependent upon factors within the follicle and how far it is subject to systemic control. When hair follicles are translocated, either by rotation of grafts in the mid-flank or by transposition of flaps in two stages, they continue to maintain the periodicity characteristic of their sites of origin (Ebling & Johnson, 1959). Vascularization of such follicles is always consequent upon follicular activity, even when this is out of phase with the normal waves of hair-growth on the adjacent body.. ...
2016. Ardan, T., Němcová, L., Bohuslavová, B., Klezlová, A., Popelka, Š., Studenovská, H.3, Hrnčiarová, E., Čejková, J., Motlík, J.: (2016) Reduced Levels of Tissue Inhibitors of Metalloproteinases (TIMPs) in UVB Irradiated Corneal Epithelium. Photochem. Photobiol., IN PRESS IF 2.008. Bílková, B., Albrecht, T., Chudičková, M., Holáň, V., Piálek, J., Vinkler, M.: (2016) Application of Concanavalin A during immune responsiveness skin-swelling tests facilitates measurement interpretation in mammalian ecology. Ecology and Evolution, 6 (13): 4551-4564. IF 2.537. Čejka, Č., Čejková, J., Trošan, P., Zajícová, A., Syková, E., Holáň, V.: (2016) Transfer of mesenchymal stem cells and cyclosporine A on alkali-injured rabbit cornea using nanofiber scaffolds strongly reduces corneal neovascularization and scar formation. Histol. Histopath., 31: 969-980. IF 1.875. Čejka, Č., Holáň, V., Trošan, P., Zajicová, A., Javorková E., Čejková, J.: (2016) The Favorable Effect of ...
Covers all areas of immunology including cellular and molecular immunology, immunochemistry, immunogenetics, imaging, mathematical modelling, allergy, transplantation immunology, cancer immunology, clinical immunology and immunological therapies, physiological functioning of the immune system in states of both health and disease, malfunctions of the immune system in immunological disorders and therapies (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection), the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.. ...
A big diversity of events takes place at the Max Planck Institute of Immunobiology and Epigenetics (MPI-IE). Weekly internal and public scientific seminars are complemented by events on a (bi/tri)annual basis ...
Seminars in Immunology is a review journal dedicated to keeping scientists informed of developments in the field of immunology on a topic by topic...
Recurrent MCs and experience 3rd potential now. Braverman IVF & Reproductive Immunology takes the time to answer this question and more, so call today!
BioLegend offers a wide array of Rat Immunology Products. BioLegend develops and manufactures world-class, cutting-edge immunological reagents for biomedical research, offered at an outstanding value.
BioLegend offers a wide array of Mouse Immunology Products. BioLegend develops and manufactures world-class, cutting-edge immunological reagents for biomedical research, offered at an outstanding value.
Read Hepatitis C: Current Controversies and Future Potential in Solid Organ Transplantation, Current Infectious Disease Reports on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Islet transplantation has been reported to induce allosensitization in the majority of type 1 diabetic recipients of fresh or shortly incubated islet grafts prepared from one to three donors ...
Originally aired on January 20, 2016 • 3:00 pm ET • Hosted by the Community of Basic Scientists DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance (Link to abstract: a subscription to Journal of Experimental Medicine is required to view the full article, AST is not permitted to distribute the full text of the article) Author: Jordi Ochando, PhD • Mount Sanai School of Medicine Moderator: Heth R. Turnquist, PhD • University of Pittsburgh
TY - JOUR. T1 - Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. AU - Garcia, M.R.. AU - Ledgerwood, L.. AU - Yang, Y.. AU - Xu, J.N.. AU - Lal, G.. AU - Burrell, B.. AU - Ma, G.. AU - Hashimoto, D.. AU - Li, Y.S.. AU - Boros, P.. AU - Grisotto, M.. AU - van Rooijen, N.. AU - Matesanz, R.. AU - Tacke, F. AU - Ginhoux, F.. AU - Ding, Y.Z.. AU - Chen, S.H.. AU - Randolph, GJ. AU - Merad, M.. AU - Bromberg, J.S.. AU - Ochando, J.C.. PY - 2010. Y1 - 2010. U2 - 10.1172/JCI41628. DO - 10.1172/JCI41628. M3 - Article. C2 - 20551515. VL - 120. SP - 2486. EP - 2496. JO - Journal of Clinical Investigation. JF - Journal of Clinical Investigation. SN - 0021-9738. IS - 7. ER - ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Nonhuman Primate Transplantation Tolerance (U01) RFA-AI-16-007. NIAID
Gentaur molecular products has all kinds of products like :SeraLab , SeraLab \ Guinea Pig Serum \ GEM-100-130-J for more molecular products just contact us
Background: Cyclosporin A (CsA) has been a cornerstone of solid organ transplantation since its introduction to the market in the early 1980s, and is a major part of the success of immunosuppression in the clinical setting ...
Research outputs, collaborations and relationships for Yale Department of Immunobiology published between 1 January 2017 - 31 December 2017 as tracked by the Nature Index.
TY - JOUR. T1 - Regenerative medicine as applied to solid organ transplantation. T2 - Current status and future challenges. AU - Orlando, Giuseppe. AU - Baptista, Pedro. AU - Birchall, Martin. AU - De Coppi, Paolo. AU - Farney, Alan. AU - Guimaraes-Souza, Nadia K.. AU - Opara, Emmanuel. AU - Rogers, Jeffrey. AU - Seliktar, Dror. AU - Shapira-Schweitzer, Keren. AU - Stratta, Robert J.. AU - Atala, Anthony. AU - Wood, Kathryn J.. AU - Soker, Shay. PY - 2011/3. Y1 - 2011/3. N2 - In the last two decades, regenerative medicine has shown the potential for bench-to-bedside translational research in specific clinical settings. Progress made in cell and stem cell biology, material sciences and tissue engineering enabled researchers to develop cutting-edge technology which has lead to the creation of nonmodular tissue constructs such as skin, bladders, vessels and upper airways. In all cases, autologous cells were seeded on either artificial or natural supporting scaffolds. However, such constructs were ...
Graham Pawelec, Ph.D., Habil earned his MA in Natural Sciences in 1978 and his Ph.D. in Transplantation Immunology in 1982 from the University of Cambridge, UK, and his Dr. habil and Venia Legendi from the University of Tübingen, Germany, where he became Professor of Experimental Immunology in 1997. From 1999 to 2017 he led the Tübingen Ageing and Tumour Immunology (TATI) group within the Second Department of Internal Medicine, University of Tübingen Hospitals System. He remains affiliated part-time with the department at the Center for Medical Research, University of Tübingen.
The cross-match is a direct compatibility test. It consists in the incubation of RBC from the blood unit with the plasma from the receiver. If the receiver has antibodies against antigens present on the RBC, there will be agglutination, direct or via antiglobulin reaction.
The mission of the ROTRF is to advance the science of solid organ transplantation in order to improve the care of the thousands of patients undergoing transplantation every year.
Agilex Biolabs, Australias largest and most technologically advanced specialist bioanalytical laboratory for clinical trials, today announced it will showcase its world-class immunoassay and immunobiology services for regulated bioanalysis at Bio-Europe 2021.
Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system. | Immunology for University Students
Immunity join our community. We offer 88 Products in our store. Our store specialize in supplying special featured herbal medecines, developed to improve your life and makes better your health. Immunology.
Tate Gisslen, Manuel Alvarez, Casey Wells, Man-Ting Soo, Donna S Lambers, Christine L Knox, Jareen K Meinzen-Derr, Claire A Chougnet, Alan H Jobe, Suhas G Kallapur ...
Organ transplantation is one of the best therapeutic options for patients with end-stage organ failure. Experimental organ transplantation is an important link between basic science and clinical practice. Both editors, Dr. Chen and Dr. Qian, have been working in this area for more than 20 years. Experts from the United States, Canada, China, Japan, Italy, Spain, Turkey, Switzerland, Hungary, and Brazil contributed 25 chapters in this book, and provided detailed descriptions of techniques for vascularized organ allografts in mice, rats, pigs, and nonhuman primates, as well as detailed descriptions of non-vascularized pancreatic islet and spleen allografts.. Furthermore, they discussed new advances in transplantation immunology. This book provides numerous important references which were carefully selected by the authors to extend their visions and knowledge. The appropriate readers of this book include medical students, graduate students, residents, surgeons, physicians and immunologists ...
Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
From experimental observations on induction of transplantation tolerance, we discuss a model that accounts for tissue-specific tolerance to antigens not
Transplantation has become standard of care to treat end-organ failure, replacing a failed organ with a functioning one. However, the toxicity of the immunosuppressive ag..
Transplants of tissues depleted of passenger leukocytes are upon in vitro culture usually accepted in allogeneic recipients. Accordingly, fully allogeneic
protocol for immunostaining primery cells - posted in Immunology: I want to stain primery cells in suspension for cofocal microscopy.(until today I had no problems with immunostaining cell which were grown on coverslips, but now its more complicated situation because the cells are much more sensitive) help? thanksHanna
Nossos profissionais nativos, com títulos de doutorado e mestrado, revisam artigos acadêmicos de Diagnostic immunology para proporcionar inglês de alta qualidade ao seu manuscrito.
Transplantation and Clinical Immunology. 29: 229-236. doi:10.1007/978-0-585-38142-8_28. ISBN 978-0-7923-4937-2.. Fischell, Tim ... including subsequent combined heart and lung transplantation and then isolated lung transplantation. This core programmatic ... "Cardiac Transplantation, co-authored with N. Shumway, S.W. Jamieson and Philip E. Oyer, in George M. Abouna's Current Status of ... In addition to transplantation, Stinson was active in the entire spectrum of adult cardiac surgery and developed special ...
... pioneer of transplantation immunology. First woman appointed to a Professorship in the faculty of Medicine (USYD). Pro-Vice ...
"Immunology of Organ Transplantation". en.ustc.findplus.cn (in Chinese). Retrieved 31 July 2017. Children in Need: Kidney ... Immunology of Organ Transplantation. Surgery. July 2014. "The Magazine of The City of London School Alumni Association Autumn ... "Immune Desensitization Allows Pediatric Blood Group Incompatible Kidney Transplantation". Transplantation. 101 (6): 1242-1246. ... He continues to lecture on 3D printing in transplantation. Chandak was invited as one of the key speakers discussing the early ...
"Robert A. Good, 81, Founder Of Modern Immunology, Dies". New York Times. Archived from the original on 4 November 2012. ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... Biology of blood and marrow transplantation. American Society for Blood and Marrow Transplantation. 2 (1): 3-14. PMID 9078349. ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ...
List of London medical students who assisted at Belsen Brent, Leslie (1997). A history of Transplantation Immunology. Academic ...
He specialises in transplantation tolerance and immunology. Since 2004, he has been Professor of Immunology at King's College ...
... (1972). Nature's Transplant: The Transplantation Immunology of Viviparity. Butterworths. ISBN 0407326502 ... was a Scottish consultant surgeon and cancer specialist whose research focused on tissue transplantation, cancer immunology and ... 1970). The Biology and Surgery of Tissue Transplantation: Proceedings of a Conference Held in Glasgow on 20-21 March 1969. ... John Maxwell Anderson (1970). The biology and surgery of tissue transplantation. Blackwell Scientific. ISBN 063206210X. ...
"Transplantation immunology: solid organ and bone marrow". J. Allergy Clin. Immunol. 125 (2 Suppl 2): S324-35. Vickers, Peter S ... Owen, Judith; Punt, Jenni (2013). Kuby Immunology. New York: W.H. Freeman and Company. "CONVERSION OF NORMAL RATS INTO SCID- ... David Vetter, the original "bubble boy", had one of the first transplantations also, but eventually died because of an ... These mice then receive bone marrow transplantation from SCID donors, allowing engraftment of human peripheral blood ...
"Immunologically privileged sites in transplantation immunology and oncology". Perspect Biol Med. 29 (1): 115-131. doi:10.1353/ ... IMMUNOLOGY - CHAPTER ONE > INNATE (NON-SPECIFIC) IMMUNITY Gene Mayer, Ph.D. Immunology Section of Microbiology and Immunology ... 2000). "RANTES binding and down-regulation by a novel human perpesvirus-6 beta chemokine receptor". Journal of Immunology. 164 ... Head, JR; Billingham RE (1985). "Immune privilege in the testis:evaluation of potential local factors for transplantation". ...
"Paediatric Immunology, Bone Marrow Transplantation and Infectious Diseases". Newcastle Hospitals. Retrieved 15 April 2018. "The ...
"Journal of Immunology. 179 (8): 5204-10. doi:10.4049/jimmunol.179.8.5204. PMC 2291549. PMID 17911605.. ... "PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection" ... American Journal of Reproductive Immunology. 74 (3): 201-8. doi:10.1111/aji.12365. PMID 25640631.. ... "Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer". Science. 348 ...
Helped launch the fields of modern immunology and organ transplantation. Richard Owen (1804-1892), biologist, paleontologist, ...
"The unfinished legacy of liver transplantation: emphasis on immunology". Transplantation Institute, Department of Surgery, ... "History of clinical transplantation". Thomas E. Starzl Transplantation Institute, University of Pittsburgh; Starzl TE. Diakses ... "History of clinical transplantation". Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center,; ... "Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine,; Oh SH, Witek RP, Bae ...
Amos made significant contributions in immunogenetics, tumor immunity, and transplantation immunology. Amos was president of ... Amos was professor of immunology and experimental surgery at Duke University from 1962 to 1993. Amos was born April 16, 1923, ... and the co-founder and editor-in-chief of the journal Human Immunology. Amos was elected to the National Academies of Science. ... 1991 The Journal of Immunology IN MEMORIAM, D. Bernard Amos April 16, 1923-May 15, 2003, Thomas F. Tedder and Jeffrey R. Dawson ...
Graham, S.M., et al., Biological therapy of bone defects: the immunology of bone allo-transplantation. Expert Opinion on ...
Astellas' franchise areas are urology, immunology (transplantation), cardiology, and infectious disease. Priority areas for R&D ...
"Transplantation tolerance and autoimmunity after xenogeneic thymus transplantation". Journal of Immunology. 166 (3): 1843-1854 ... Thymus transplantation[edit]. Thymus transplantation may be said to be able to cause a special type of GvHD because the ... Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation. 22 (5): 910- ... "Biology of Blood and Marrow Transplantation. 11 (12): 945-956. doi:10.1016/j.bbmt.2005.09.004. PMC 4329079. PMID 16338616.. ...
His interests are dendritic cell immunology, cell transplantation, liver research, and immunity. His highest cited paper is " ... Angus W. Thomson is an American immunologist currently Distinguished Professor of Surgery and Immunology at Starzl Institute, ... "Angus Thomson". University of Pittsburgh Department of Immunology. Morelli, Adrian E.; Thomson, Angus W. (August 2007). " ... "Angus W. Thomson". University of Pittsburgh Starzl Transplantation Institute. " ...
"Robert A. Good, 81, Founder Of Modern Immunology, Dies". New York Times ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2 (1): 3-14 ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ...
Her research interests include corneal transplantation, ocular inflammation, ocular immunology and eye banking. Williams ... service to medical science in the field of ophthalmology through the research and development of corneal transplantation, as an ...
"Trends in Immunology. 32 (2): 50-56. doi:10.1016/j.it.2010.12.004. PMC 3039080. PMID 21288770.. ... During transplantation[edit]. While during infection T cell exhaustion can develop following persistent antigen exposure after ... "Clinical and Experimental Immunology. 176 (2): 266-74. doi:10.1111/cei.12277. PMC 3992039. PMID 24450998.. ... "Frontiers in Immunology. 6: 344. doi:10.3389/fimmu.2015.00344. PMC 4492155. PMID 26217338.. ...
D. Bernard Amos, 80, American immunologist, contributed to immunogenetics, tumor immunity and transplantation immunology. June ... The Journal of Immunology. Retrieved May 6, 2019. "WILLIAM C. ANDERSON, PILOT, AUTHOR". Sun-Sentinel. June 1, 2003. Retrieved ...
"Corneal Transplantation and Immune Privilege". International Reviews of Immunology. 32 (1): 57-67. doi:10.3109/08830185.2012. ... "International Reviews of Immunology. 32 (1): 57-67. doi:10.3109/08830185.2012.737877. ISSN 0883-0185. PMC 3885418. PMID ... "Frontiers in Immunology. 7: 37. doi:10.3389/fimmu.2016.00037. PMC 4744940. PMID 26904026.. ... "webMIC 419: Immunology. University of Arizona. Arhivirano s originala, 10. 6. 2003.. CS1 održavanje: nepreporučeni parametar ( ...
For more than 17 years he operated a laboratory in transplantation immunology at Massachusetts General Hospital. In 1998, he ... In 2005, Auchincloss was elected president of the American Society of Transplantation. He has authored scientific articles and ... founded the Juvenile Diabetes Research Foundation Center for Islet Transplantation and served as its director until 2003. He ...
"Hematopoietic stem cell transplantation for X-linked thrombocytopenia with mutations in the WAS gene." Journal of clinical ... immunology 35.1 (2014): 15-21. Zhang, X., et al. "[Clinical characteristics and treatment responses of X-linked ... Recent research has suggested that hematopoietic stem cell transplantation may be a treatment option for patients with XLT ...
Simpson, E. (2015). "Medawar's legacy to cellular immunology and clinical transplantation: a commentary on Billingham, Brent ... Ono, Santa Jeremy (2004). "The Birth of Transplantation Immunology: the Billingham--Medawar Experiments at Birmingham ... It directly laid the foundation for the first successful organ transplantation in humans, specifically kidney transplantation, ... For his scientific works he is regarded as the "father of transplantation". He is remembered for his wit both in person and in ...
A number of research deal with the development of a strategy utilizing this phenomenon in transplantation immunology. The goal ... In 1989 was successfully induced classical transplantation tolerance to skin grafts in adult mice using antibodies blocking T ... Gershon, R. K. (1975). "A disquisition on suppressor T cells". Transplantation Reviews. 26: 170-185. doi:10.1111/j.1600-065x. ... Qin, S. X.; Cobbold, S.; Benjamin, R.; Waldmann, H. (1989-03-01). "Induction of classical transplantation tolerance in the ...
Seminars in Immunology. Advances in Transplantation. 23 (4): 304-313. doi:10.1016/j.smim.2011.04.001. ISSN 1044-5323. PMC ... Conforti L (February 2012). "The ion channel network in T lymphocytes, a target for immunotherapy". Clinical Immunology. 142 (2 ... It has been tested on transplantations, rheumatoid arthritis, type 1 diabetes and other autoimmune disorders. Immunotherapy can ... Immunosuppressive drugs help manage organ transplantation and autoimmune disease. Immune responses depend on lymphocyte ...
... bone marrow transplantation, and HIV-1 infection. Annual Review of Immunology. 2000, 18: 529-560 [2020-02-23]. ISSN 0732-0582. ... Clinical Immunology. 2012-02-10, 142 (2): 105-106 [2020-02-23]. doi:10.1016/j.clim.2011.11.009. (原始内容存档于2020-03-18) (英语).. ... Nature Immunology. 2010-06, 11 (6): 512-519 [2020-02-23]. ISSN 1529-2916. PMID 20431619. doi:10.1038/ni.1874. (原始内容存档于2020-03- ... Nature Immunology. 2013-04, 14 (4): 307-308 [2020-02-23]. ISSN 1529-2916. PMID 23507634. doi:10.1038/ni.2554. (原始内容存档于2020-
... bone marrow transplantation, and HIV-1 infection. Annual Review of Immunology. 2000, 18: 529-560. ISSN 0732-0582. PMID 10837068 ... Immunology. 2010-04, 129 (4): 474-481. ISSN 1365-2567. PMC 2842494. PMID 20201977. doi:10.1111/j.1365-2567.2010.03255.x.. ... Frontiers in Immunology. 2018, 9: 219. ISSN 1664-3224. PMC 5816053. PMID 29483916. doi:10.3389/fimmu.2018.00219.. ... Annual Review of Immunology. 2003, 21: 139-176. ISSN 0732-0582. PMID 12414722. doi:10.1146/annurev.immunol.21.120601.141107.. ...
It is also used as induction therapy in highly sensitized patients going for kidney transplantation. The use of rituximab has ... "Genentech: Products - Product Information - Immunology - Rituxan RA Full Prescribing Information". Archived from the original ...
Immunology is the study of the immune system, which includes the innate and adaptive immune system in humans, for example. ...
Röntgen discovered X-rays' medical use when he made a picture of his wife's hand on a photographic plate formed due to X-rays. The photograph of his wife's hand was the first ever photograph of a human body part using X-rays. When she saw the picture, she said, "I have seen my death."[28] The first use of X-rays under clinical conditions was by John Hall-Edwards in Birmingham, England on 11 January 1896, when he radiographed a needle stuck in the hand of an associate. On 14 February 1896, Hall-Edwards also became the first to use X-rays in a surgical operation.[29] The United States saw its first medical X-ray obtained using a discharge tube of Ivan Pulyui's design. In January 1896, on reading of Röntgen's discovery, Frank Austin of Dartmouth College tested all of the discharge tubes in the physics laboratory and found that only the Pulyui tube produced X-rays. This was a result of Pulyui's inclusion of an oblique "target" of mica, used for holding samples of fluorescent material, within the ...
Renal transplantation replaces kidney function by inserting into the body a healthier kidney from an organ donor and inducing ... Nephrologists may further sub-specialise in dialysis, kidney transplantation, chronic kidney disease, cancer-related kidney ... At present, renal transplantation is the most effective treatment for end-stage kidney failure although its worldwide ... dialysis or kidney transplantation) and plasma exchange. Kidney problems can have significant impact on quality and length of ...
Hair transplantation - a cosmetic procedure practiced by many dermatologists.. *Intralesional treatment - with steroid or ...
"Journal of Allergy and Clinical Immunology. 126 (3): 527-534.e8. doi:10.1016/j.jaci.2010.05.016. PMC 2933964 .. ... Lung transplantation. Decortication of lung. Heart-lung transplant. Chest wall, pleura,. mediastinum,. and diaphragm. pleura/ ... American Academy of Allergy, Asthma, and Immunology, "Five Things Physicians and Patients Should Question" (PDF), Choosing ... Journal of Allergy and Clinical Immunology. 127 (2): 549-549. doi:10.1016/j.jaci.2010.10.053.. ...
His interest in immunology has led to publications in HIV disease, cellular activation and natural killer cell function, tumor ... platelet activation in vascular disease and stem cell transplantation in cancer patients. As an endocrinologist he has an ... Clinical Immunology and Immunopathology, 1994; 70:152-158. K. Strauss, I. Hannet, S. Engels, A. Shiba, D. Ward, S. Ullery, M. ... Clinical Immunology and Immunopathology, 1997:122-128. F. Hulstaert, I. Hannet, V. Deneys, V. Munhyeshuli, T. Reichert, M. ...
Immunology : journal. - 2001. - Vol. 102, no. 2. - P. 173-179. - DOI:10.1046/j.1365-2567.2001.01163.x. - PMID 11260322. ... Transplantation. - 2005. - Т. 79, № 3. - С. 282-288. - DOI:10.1097/01.TP.0000149506.61000.86. - PMID 15699757. ...
Virus-specific T-Lymphocytes (VST) therapy is used for patients who have received hematopoietic stem cell transplantation that ... Frontiers in Immunology. 5 (162): 1-33. doi:10.3389/fimmu.2014.00162. Notarangelo L, Casanova JL, Conley ME, et al. (2006). " ... June 2008). "Stem cell transplantation for primary immunodeficiencies". Bone Marrow Transplant. 41 Suppl 2: S83-6. doi:10.1038/ ... Journal of Allergy and Clinical Immunology. doi:10.1016/j.jaci.2015.12.1311. Retrieved 12 April 2016. Boyle JM, Buckley RH ( ...
... surgical techniques are used to remove an invasive malignancy that extends to the clitoris. Standard surgical procedures are followed in these cases. This includes evaluation and biopsy. Other factors that will affect the technique selected are age, other existing medical conditions, and obesity. Other considerations are the probability of extended hospital care and the development of infection at the surgical site.[3] The surgery proceeds with the use of general anesthesia, and prior to the vulvectomy/clitoridectomy an inguinal lymphyadenectomy is first done. The extent of the surgical site extends one to two centimeters beyond the boundaries of malignancy. Superficial lymph nodes may also need to be removed. If the malignancy is present in muscular tissue in the region, it is also removed. In some cases, the surgeon is able to preserve the clitoris though the malignancy may be extensive. The cancerous tissue is removed and the incision is closed.[3] Post operative care may ...
"Bone Marrow Transplantation. 31: 411-412. doi:10.1038/sj.bmt.1703857.. Pemeliharaan CS1: Banyak nama: authors list (link) ... Paul H. Jacobs, Lexie Nall (1996). Fungal disease: biology, immunology, and diagnosis. Informa Healthcare. ISBN.. ...
Damasio formulated the somatic marker hypothesis,[5] a theory about how emotions and their biological underpinnings are involved in decision-making (both positively and negatively, and often non-consciously). Emotions provide the scaffolding for the construction of social cognition and are required for the self processes which undergird consciousness.[citation needed] "Damasio provides a contemporary scientific validation of the linkage between feelings and the body by highlighting the connection between mind and nerve cells ... this personalized embodiment of mind."[6] The somatic marker hypothesis has inspired many neuroscience experiments carried out in laboratories in the U.S. and Europe, and has had a major impact in contemporary science and philosophy.[7] Damasio has been named by the Institute for Scientific Information as one of the most highly cited researchers in the past decade. Current work on the biology of moral decisions, neuro-economics, social communication, and drug-addiction, ...
"Nephrology Dialysis Transplantation. 17 (6): 1014-1018. doi:10.1093/ndt/17.6.1014. ISSN 0931-0509. PMID 12032190.. ...
In a number of countries, the pathway to become a subspecialist in REI is regulated. Thus, in the United States, for instance, the American Board of Obstetrics and Gynecology (ABOG) and American Osteopathic Board of Obstetrics and Gynecology set the standards for subspecialists to become certified. After four years of training in Obstetrics and Gynecology, a three-year approved fellowship needs to be successfully completed. Then, to become board certified in reproductive endocrinology and infertility, one must first complete board certification in obstetrics and gynecology (written and oral exams), and then certify in reproductive endocrinology and infertility (written and oral exams). In the United States, fellowship in reproductive endocrinology and infertility usually takes 3 years, and is offered in 40 centers across the country as of 2013.[2] In the European Union, the European Board and College of Obstetrics and Gynaecology (EBCOG) has accreditation centers for a subspecialist training ...
Huntington's is caused by an autosomal dominant mutation expanding the number of glutamine codon repeats (CAG) within the Huntingtin gene (Htt).[79] The Htt gene encodes for the huntingtin protein which plays a role in normal development but its exact function remains unknown.[80] The length of this CAG repeat correlates with the age-of-onset of the disease. The average person without Huntington's has less than 36 CAG repeats present within the Htt gene. When this repeat length exceeds 36, the onset of neuronal degradation and the physical symptoms of Huntington's can range from as early as 5 years of age (CAG repeat , 70) to as late as 80 years of age (CAG repeat , 39).[81] This CAG expansion results in mRNA downregulation of specific genes, decreased histone acetylation, and increased histone methylation.[82][83] The exact mechanism of how this repeat causes gene dysregulation is unknown, but epigenome modification may play a role. For early-onset Huntington's (ages 5-15), both transgenic mice ...
S Fagarasan; T Honjo (2003). "Intestinal IgA Synthesis: Regulation of Front-line Body Defenses". Nature Reviews Immunology. 3 ( ... Liver transplantation. *Portal hypertension *Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt ...
Other noted programs include: cellular and structural biology, urology, nephrology, transplantation biology, aging and ... Microbiology and Immunology, Molecular Medicine, Pathology, Pharmacology, Pharmacy, Nursing, Physiology, Radiological Sciences. ...
2019-03-19: Cell Transplantation. *2019-03-14: Journal of Speech, Language, and Hearing Research ... 2019-09-28: Allergy, Asthma & Immunology Research. *2019-09-22: ACS Central Science ...
For the development of liver transplantation, which has restored normal life to thousands of patients with end-stage liver ... achievement that provided the organizing principle of the adaptive immune system and launched the course of modern immunology.[ ...
Even though the idea of using computers in medicine emerged as technology advanced in the early 20th century, it was not until the 1950s that informatics began to have an effect in the United States.[41] The earliest use of electronic digital computers for medicine was for dental projects in the 1950s at the United States National Bureau of Standards by Robert Ledley.[45] During the mid-1950s, the United States Air Force (USAF) carried out several medical projects on its computers while also encouraging civilian agencies such as the National Academy of Sciences - National Research Council (NAS-NRC) and the National Institutes of Health (NIH) to sponsor such work.[46] In 1959, Ledley and Lee B. Lusted published "Reasoning Foundations of Medical Diagnosis," a widely read article in Science, which introduced computing (especially operations research) techniques to medical workers. Ledley and Lusted's article has remained influential for decades, especially within the field of medical decision ...
Bone marrow transplantation. *Gene therapy. Career paths and training[edit]. The examples and perspective in this article deal ...
The blood type needs to be determined to prepare for a blood transfusion or an organ transplantation. ... Nature Immunology. 8 (10): 1114-22. doi:10.1038/ni1501. PMID 17721536.. CS1 maint: Uses authors parameter (link). ...
Recently, advances in immunology have allowed the function of the thymus in T-cell maturation to be more fully understood. The ... The newly formed organ resembled a normal thymus histologically and molecularly, and upon transplantation it was able to ... Nature Reviews Immunology. 8 (12): 948-957. doi:10.1038/nri2450. PMC 2785478 . PMID 19008896. Wadhera A, Maverakis E, Mitsiades ... Clinical and Experimental Immunology. 145 (3): 407-412. doi:10.1111/j.1365-2249.2006.03139.x. PMC 1809694 . PMID 16907907. ...
In most cases the use of Medical Nutrition is recommended within international and professional guidelines.[10] It can be an integral part of managing acute and short-term diseases. It can also play a major role in supporting patients for extended periods of time and even for a lifetime in some special cases.[10] Medical Nutrition is not meant to replace the treatment of disease but rather complement the normal use of drug therapies prescribed by physicians and other licensed healthcare providers.[10]. Unlike Medical Foods which are defined by the U.S. Department of Health and Human Services' Food and Drug Administration, {within their 'Medical Foods Guidance Documents & Regulatory Information' guide in section 5(b) of the Orphan Drug Act (21 U.S.C. 30ee (b) (3))}; as "a food which is formulated to be consumed or administered enterally under the supervision of a physician and which is intended for the specific dietary management of a disease or condition for which distinctive nutritional ...
"Biology of Blood and Marrow Transplantation. 15 (12): 1628-33. PMC 2861656 . PMID 19896087. doi:10.1016/j.bbmt.2009.07.004.. ... Immunology. 40 (3): 181-91. PMID 20107927. doi:10.1007/s12016-009-8196-0.. ... In chemotherapy as a conditioning regimen in hematopoietic stem cell transplantation, a study of patients conditioned with ... "Fertility issues following hematopoietic stem cell transplantation". Expert Review of Hematology. 6 (4): 375-388. PMID ...
Iatrogenic transmission, due to medical procedures such as injection or transplantation of infected material. ... "Nature Immunology. 14 (7): 654-59. doi:10.1038/ni.2614. PMC 3760236. PMID 23778792.. ...
Wallace JL, Ianaro A, Flannigan KL, Cirino G (2015). "Gaseous mediators in resolution of inflammation". Seminars in Immunology ... lung transplantation rejection, and neuropathic pain while promoting skin wound healing. These actions are similar to those of ...
Immunology → 면역학 (D). *Neurology → 신경학 (C). *Obstetrics and gynaecology → 산부인과 (E). *Oncology → 종양학 (E) ... Organ transplantation → 장기 이식 (B). *Palliative care *Radiation therapy → 방사선종양학과 (E). *Surgery → 외과 (E) ...
Source for information on Transplantation Genetics and Immunology: World of Microbiology and Immunology dictionary. ... Transplantation genetics and immunology There are several different types of transplantation. An autograft is a graft from one ... "Transplantation Genetics and Immunology." World of Microbiology and Immunology. . Encyclopedia.com. (November 12, 2018). https ... World of Microbiology and Immunology COPYRIGHT 2003 The Gale Group Inc.. Transplantation genetics and immunology. There are ...
... CIRM Stem Cell Transplantation Immunology Awards. The potential for stem cells to replace or ... Stem Cell Transplantation Immunology Letter of Intent Form (pdf). Application Instructions and Forms. Applications will only be ... Stem Cell Transplantation Immunology LOI. California Institute for Regenerative Medicine. 210 King Street. San Francisco, Ca ... Stem Cell Transplantation Immunology Application. California Institute for Regenerative Medicine. 210 King Street. San ...
Are Liver Cystic Lesions after Islet Transplantation Caused by Streptozotocine? LUCIE KOSINOVÁ, ALZBETA PATIKOVA, EVA STICOVA, ... Flash Glucose Monitoring Reflects Graft Function after Clinical Islet Transplantation-An Initial Report ANNA LAM, SHAREEN ...
Transplantation has been a major breakthrough in medicine during the 20th Century. It has been made possible conceptually due ... Organ Transplantation is a replacement therapy for end-stage organ failure and allogeneic HSCT is effective as a cellular ... Organ transplantation and allogeneic HSCT have in common to deal with the side-effects of heavy immunosuppression, such as ... Alloimmunity and Transplantation welcomes submissions of the following article types: Case Report, Classification, Clinical ...
Local Sphingosine Kinase 1 Activity Improves Islet Transplantation Darling Rojas-Canales, Daniella Penko, Kay K. Myo Min, Kate ... Pancreatic β-Cell-Derived IP-10/CXCL10 Isletokine Mediates Early Loss of Graft Function in Islet Cell Transplantation Gumpei ...
Tissue Transplantation and Cellular Immunology Lead researcher. R Fowler Jnr, J E Carey, P Johansen ...
Transplantation immunology: what the clinician needs to know for immunotherapy.. Rosen HR1. ... Division of Gastroenterology & Hepatology, Liver Transplantation, Hepatitis C Center, Department of Medicine, University of ...
Postoperative Portal Hypertension Enhances Alloimmune Responses after Living-Donor Liver Transplantation in Patients and in a ... Graft γδ TCR Sequencing Identifies Public Clonotypes Associated with Hematopoietic Stem Cell Transplantation Efficacy in Acute ... on NK Cell Reconstitution and Clinical Outcome after T Cell-Replete Haploidentical Hematopoietic Stem Cell Transplantation with ...
Role of exosomes in rejection following human lung transplantation - an in vitro analysis using human airway epithelial cells ...
RESEARCH DESCRIPTION The Division of Transplantation Immunology and Mucosal Biology has a strong interest in basic biological ... Review Graduate Program details of Transplantation Immunology & Mucosal Biology in London United Kingdom from Kings College ... RESEARCH DESCRIPTION The Division of Transplantation Immunology and Mucosal Biology has a strong interest in basic biological ... The Division is home to the MRC Centre for Transplantation which brings together research across disciplines including genetics ...
The most successful protocols have relied on transfusion of bone marrow prior to the transplantation of a renal allograft. ... The most successful protocols have relied on transfusion of bone marrow prior to the transplantation of a renal allograft. ... Cell based therapies have been studied extensively in the context of transplantation tolerance induction. ... Cell based therapies have been studied extensively in the context of transplantation tolerance induction. ...
We have studied two transplantation models. This first involves transplantation of retinal pigment epithelial (RPE) cells as a ... of heart transplantation patients after the first three years post-transplantation. They use induced mutant mice to study the ... Transplantation Faculty active in this area of research are listed below. For a brief description of their research interests, ... To this end, we have developed an active research program in kidney and kidney/pancreas transplantation that spans the spectrum ...
Clinical transplantation surgery and experimental immunology. The research group is focused on mechanisms that regulate the ... ABO-incompatible liver transplantation. *Liver transplantation as rescue treatment after liver resections and surgical ... Division of Transplantation Surgery, Karolinska University Hospital Huddinge, Solna, Sweden.. *Transplantation and Liver ... Liver transplantation for colorectal liver metastases. *Clinical and Surgical Aspects of Complications in Kidney ...
... transplantation and infection and to translate this new knowledge to novel strategies for diagnosis, prevention and therapeutic ... The Penn Institute for Immunologys mission is to advance our knowledge of the basic immunology of inflammation, autoimmunity, ... American journal of transplantation : official journal of the American Society of Transplantation and the American Society of ... American journal of transplantation : official journal of the American Society of Transplantation and the American Society of ...
The Columbia Center for Translational Immunology (CCTI). Copyright © 2015 The Columbia Center for Translational Immunology ,, ... News Related to: Transplantation Balancing Act. * Susan DeWolf Receives ASH Abstract Achievement Award. For Quantifying the ... The CCTI has been selected to receive the International Transplantation Science Mentee-Mentor Award 2017 given by The ...
The grants are two of 19 Stem Cell Transplantation Immunology awards totaling $25 million that were approved at the June 23 ... CIRM Awards More Than $2.5 Million in Transplantation Immunology Grants to Two UC San Diego Researchers ...
... and mechanisms of its prevention after allogeneic hematopoietic cell transplantation (HCT). Projects will include extensive ... which provides a vibrant and enriching environment for research in immunology, immunotherapy, transplantation, and cancer with ... Experimental Transplantation and Immunotherapy Branch - Christopher G. Kanakry, M.D.. We are recruiting a highly motivated ... The use of post-transplantation cyclophosphamide (PTCy) as GVHD prophylaxis recently has revolutionized the HCT field by making ...
... are important in transplantation, the majority of treatment modalities in transplantation are directed against the adaptive ... In living donor transplantation a 2 haplo matched kidney transplant carries the lowest risk of rejection and best graft ... Monitoring donor specific antibodies (DSA): Donor specific antibodies may be present before transplantation (as in sensitized ... It is almost devoid of side effects and is given as a dose of 20 mg on days 0 and 4 post transplantation. ...
Simeonovic, C, Townsend, M, Karupiah, G et al 1999, Analysis of the Th1/Th2 paradigm in transplantation: interferon-gamma ... Simeonovic, C 1999, Xenogeneic islet transplantation, Xenotransplantation, vol. 6, no. 1, pp. 1-5. ... 2013, Heparanase and autoimmune diabetes, Frontiers in Immunology, vol. 4, pp. 1-7. ... at the 2012 Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand held in Canberra, 27-29 June ...
Th1 Cells - immunology - transplantation Th2 Cells - immunology - transplantation Abstract. Th2 T cell immune-driven ... Lung - cytology - immunology Male Ovalbumin - administration & dosage - immunology Pulmonary Eosinophilia - immunology - ... Bronchoalveolar Lavage Fluid - immunology Cell Line Epitopes, T-Lymphocyte - administration & dosage - immunology Inflammation ... Epitopes, T-Lymphocyte - administration & dosage - immunology 1 * Inflammation - immunology - pathology - prevention & control ...
The transplantation immunology of certain mammalian mothers and progeny Message Subject (Your Name) has sent you a message from ... The transplantation immunology of certain mammalian mothers and progeny. J. M. Anderson ... The transplantation immunity of viviparity has been studied by orthotopic transplantation of skin between outbred mothers and ...
... hence in immunology the term transplantation is used to refer the procedure involved in ... The term transplantation means removing something from one location and introducing it in another location, ... Study of Mouse skin graft rejection further improved the knowledge of transplantation immunology, and it helped a lot in ... hence in immunology the term transplantation is used to refer the procedure involved in the replacement of a nonfunctional or ...
Science Immunology. 14 Jul 2016. : aaf8759 Early T cell activation by recipient antigen-presenting cells cross-dressed with ... Science Immunology. 14 Jul 2016. : aaf8759 Early T cell activation by recipient antigen-presenting cells cross-dressed with ... Your Name) has forwarded a page to you from Science Immunology Message Body. (Your Name) thought you would like to see this ... Research ArticleTRANSPLANTATION. Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after ...
... ... Kidney transplantation significantly improves the survival of end stage renal disease patients. The outcome after kidney ... immune-profile-race-rejection-kidney-transplantation-projectCurrently selected. *microenvironment-driven-reshaping-pathogenic-t ...
Home // CiviCRM // CiviCRM // Discovery to clinical applications of Regulatory T cells in autoimmunity and transplantation ... Discovery to clinical applications of Regulatory T cells in autoimmunity and transplantation. ... Discovery to clinical applications of Regulatory T cells in autoimmunity and transplantation ... clinical applications of Regulatory T cells in autoimmunity and transplantationsis hosted by the BSI West Midlands Immunology ...
Clinical and Diagnostic Laboratory Immunology Nov 2000, 7 (6) 889-892; DOI: 10.1128/CDLI.7.6.889-892.2000 ... Clinical and Diagnostic Laboratory Immunology Nov 2000, 7 (6) 889-892; DOI: 10.1128/CDLI.7.6.889-892.2000 ... Thank you for sharing this Clinical and Vaccine Immunology article.. NOTE: We request your email address only to inform the ... Procalcitonin Does Not Discriminate Infection from Inflammation after Allogeneic Bone Marrow Transplantation. N. M. A. ...
Risk factors and outcomes of hypogammaglobulinemia after lung transplantation. Transplantation 79:1723-1726. ... Clinical and Vaccine Immunology Jul 2006, 13 (7) 740-746; DOI: 10.1128/CVI.00139-06 ... Effect of transplantation on IgM to GXM. The levels of IgM to GXM in paired serum samples from nine C. neoformans-positive ... Clinical and Vaccine Immunology Jul 2006, 13 (7) 740-746; DOI: 10.1128/CVI.00139-06 ...
Monitoring the Alloresponse Before and After Transplantation (Timely Topics in Transplantation Webinar). March 31, 2015 from 10 ... The American Society of Transplantation is an organization of professionals dedicated to advancing the field of transplantation ... American Foundation for Donation & Transplantation Quality Issues in Transplantation. September 15 - 16, 2011 ... Asian Transplantation Week 2018 Unknown November 14, 2018 from 02:00pm to 03:00pm EST Transplant Metrics - Should We Enforce or ...
Molecular Immunology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic ... "S-Adenosylmethionine attenuates bile duct early warm ischemia reperfusion injury after rat liver transplantation, ... Risk factors of severe ischemic biliary complications after liver transplantation. Wang, M.F.; Jin, Z.K.; Chen, D.Z.; Li, X.L ... S-Adenosylmethionine attenuates bile duct early warm ischemia reperfusion injury after rat liver transplantation. Tang, Yong; ...
... transplantation has progressed from being an experimental procedure to a routine clinical therapy offering immense benefits for ... and many of the complications of transplantation result from the crude nature of our attempts to suppress these.... ... p. 280) Principles of transplantation immunology. Chapter:. (p. 280) Principles of transplantation immunology. Author(s):. Ross ... Since the first successful transplant of a kidney between identical twins in 1955, transplantation has progressed from being an ...
  • He and his colleagues perform clinical studies using patient data as well as basic molecular studies using a mouse heart and kidney transplantation models. (uab.edu)
  • Kidney transplantation significantly improves the survival of end stage renal disease patients. (singhealth.com.sg)
  • Immunosuppressive regimens vary but are similar to those for kidney transplantation or liver transplantation (eg, anti-IL-2 receptor monoclonal antibodies, a calcineurin inhibitor, corticosteroids-see table Immunosuppressants Used to Treat Transplant Rejection ). (msdmanuals.com)
  • Pediatric kidney transplantation is acknowledged as the treatment alternative for youngsters with a definite phase of renal sickness. (nephroconferences.com)
  • This review article provides overview of research surrounding the importance of graft specifc B cells in kidney transplantation. (scifed.com)
  • Alemtuzumab use has been increasing in kidney transplantation. (nih.gov)
  • Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. (elsevier.com)
  • In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. (elsevier.com)
  • The transplantation immunity of viviparity has been studied by orthotopic transplantation of skin between outbred mothers and offspring of four mammalian species. (royalsocietypublishing.org)
  • The experience with the study of transplantation immunity and the combination of nanotechnologies with stem cell research enable to propose and test novel therapeutic approaches. (cas.cz)
  • Nonetheless, the replacement of diseased organs by transplantation of healthy tissues has frustrated medical science because the immune system of the recipient recognizes that the donor organ is not "self" and rejects the new organ. (encyclopedia.com)
  • However, allogenicity drives rejection in organ transplantation, graft-versus-host disease in hematopoietic stem cell transplantation (HSCT), which are still major limitations. (frontiersin.org)
  • Organ Transplantation is a replacement therapy for end-stage organ failure and allogeneic HSCT is effective as a cellular immunotherapy able to cure fatal hematological malignancies. (frontiersin.org)
  • Organ transplantation and allogeneic HSCT have in common to deal with the side-effects of heavy immunosuppression, such as severe infections, an increased risk of secondary malignancies, and late side-effects impacting quality of life. (frontiersin.org)
  • Among the many different aspects which will be covered in Alloimmunity and Transplantation are: MHC and Immunogenetics, Tolerance in an allogeneic setting, Immune reconstitution after allogeneic HSCT, innovative immunosuppressive strategies and biotherapies, cellular therapy in the control of allogeneicity, novel donor sources and availability in organ transplantation and HSCT, ethics of organ and HSCT donation, and impact on quality of life. (frontiersin.org)
  • Its collaborative programmes apply to solid organ, tissue and cell transplantation. (gradschools.com)
  • In physiological situations such as solid organ transplantation, chronic viral diseases, and organ specific autoimmune diseases, antigen is usually not cleared, but the immune system develops various control mechanisms that limit immune damage. (uab.edu)
  • James F. George, PhD Dr. George's research focuses on the mechanisms of transplantation tolerance induction and immunologic mechanisms of vascular disease in solid organ transplant patients. (uab.edu)
  • While this diversity protects us from pathogens, it also provides a large number of immune targets after organ transplantation. (oncologynurseadvisor.com)
  • The term "transplantation" means removing something from one location and introducing it in another location, hence in immunology the term transplantation is used to refer the procedure involved in the replacement of a nonfunctional or damaged organ or tissue with a good, and functional organ or tissue to safe guard the life of an individual. (preservearticles.com)
  • Despite the successful use of organ transplantation in the clinic, the mechanisms behind early rejection of transplants remain unclear. (sciencemag.org)
  • Cryptococcosis is an important complication of solid-organ transplantation, but the risk factors for disease are poorly understood. (asm.org)
  • The goal of this study was to investigate whether specific or nonspecific serum immunoglobulin levels determined in samples obtained before and after solid-organ transplantation differed in patients who did or did not develop cryptococcosis after transplantation. (asm.org)
  • The results showed that solid-organ transplantation had a significant effect on total immunoglobulin and GXM-reactive antibody levels. (asm.org)
  • Hence, cryptococcosis is an emerging and important infectious complication of solid-organ transplantation. (asm.org)
  • Since the first successful transplant of a kidney between identical twins in 1955, transplantation has progressed from being an experimental procedure to a routine clinical therapy offering immense benefits for patients with organ failure, but the survival of transplanted organs remains limited by the body's immune responses, and many of the complications of transplantation result from the crude nature of our attempts to suppress these. (oxfordmedicine.com)
  • Histocompatibility & Transplant Immunology department has state of the art facilities for the testing of solid organ and stem cell transplantation. (lalpathlabs.com)
  • Transplantation medicine can be subdivided into solid organ transplantation and blood transfusion. (lecturio.com)
  • Solid organ transplantation can be xenograft, autograft, isograft and allograft. (lecturio.com)
  • Developments in marrow and organ transplantation are mutually interactive. (ox.ac.uk)
  • Transplantation is an act of transferring cells, tissues, or organ from one site to other. (conferenceseries.com)
  • Development of the field of organ and tissue transplantation has accelerated remarkably since the human major histocompatibility complex (mhc) was discovered in 1967. (conferenceseries.com)
  • The development of pharmacologic and biological agents that interfere with the alloimmune response and graft rejection has had a crucial role in the success of organ transplantation. (conferenceseries.com)
  • The Kidney is the most ordinarily transplanted organ from a living contributor and the diminished giver transplantation is where the given kidney takes from passed on an individual. (nephroconferences.com)
  • Also searched for Transplantation , Organ Transplants , and Renal . (clinicaltrials.gov)
  • Transplantation guidelines in response to the providing of organs by means of dwelling donors also are defined, as is the effect of behind schedule graft functionality on organ allocation. (sk2arch.com)
  • Transplantation Laboratory has been organising Principles of organ transplantation course every other year from 2005 onwards for medical students, nurses, and registrars. (helsinki.fi)
  • Find here the program of the Principles of organ transplantation 2016 course in Finnish. (helsinki.fi)
  • Renkonen R, Lemström K, Mäkisalo H. Organ and tissue transplantation, In the textbook of Immunology: microbiology, immunology, and infectious diseases (In Finnish: Elin- ja kudossiirrot, Immunologia: mikrobiologia, immunologia ja infektiosairaudet). (helsinki.fi)
  • 1995 (Sept) Lecturer in Molecular Biology of Organ Transplantation, Department of Surgery, University of Newcastle Upon Tyne. (ncl.ac.uk)
  • 3. I was awarded special recognition award by Roche Organ Transplantation research Fund for my contribution to research in Transplantation (cash award of 1000 Swiss Francs)-April 2011. (ncl.ac.uk)
  • Most women had their pregnancies many years before subsequent organ transplantation, and sera dating back to these sensitizing events are usually not available for analysis. (wiley.com)
  • The most successful protocols have relied on transfusion of bone marrow prior to the transplantation of a renal allograft. (frontiersin.org)
  • In their seminal work published in the New England Journal of Medicine in 2008, investigators described the clinical course of five patients who received conditioning, bone marrow transplantation, and subsequent renal transplantation. (frontiersin.org)
  • Thus, allocation of manpower and resources for surgical research can be considered particu- 1arly profitable as convincingly shown, for instance, in renal transplantation by comparison of the long-term burden of hemodialysis vs. kidney grafting, apart from the relief of suffering and misery. (springer.com)
  • T 3, renal transplantation. (biomedcentral.com)
  • The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. (elsevier.com)
  • To predict rejection in renal transplantation by immune parameters . (bvsalud.org)
  • Preformed donor-specific HLA-antibodies are a major risk factor for antibody-mediated rejection and inferior allograft survival in renal transplantation [ 1, 2 ]. (wiley.com)
  • Transplantation immunology: what the clinician needs to know for immunotherapy. (nih.gov)
  • The successful applicant will join the laboratory of Dr. Christopher Kanakry, Lasker Clinical Research Scholar/Tenure-Track Investigator, within the Experimental Transplantation and Immunotherapy Branch, CCR, NCI, NIH. (cancer.gov)
  • The Kanakry Laboratory is within the broader NCI community, which provides a vibrant and enriching environment for research in immunology, immunotherapy, transplantation, and cancer with ready access to numerous cutting-edge technologies. (cancer.gov)
  • My main area of research is studying the immunobiological processes that result in tissue damage, which has applications in transplantation immunobiology and cancer immunotherapy. (ncl.ac.uk)
  • Even though development in surgical techniques allowed clinicians to perform transplantation of organs or tissues, certain barriers such as availability of donors, expenditure for the clinical procedure and implant rejection reactions etc. made it a difficult and cumbersome procedure. (preservearticles.com)
  • Study of Mouse skin graft rejection further improved the knowledge of transplantation immunology, and it helped a lot in understanding major histo compatibility antigens. (preservearticles.com)
  • These findings suggest that perturbations in the preexisting antibody or B-cell repertoire and/or related to treatment of rejection, transplantation, or immunosuppressive therapy could translate into an increased risk for transplant-associated cryptococcosis. (asm.org)
  • A panel of recognized experts in liver transplantation pathology, hepatology, and surgery was convened for the purpose of developing a consensus document for the grading of acute liver allograft rejection that is scientifically correct, simple, and reproducible and clinically useful. (mendeley.com)
  • In addition, IgA increased pre- transplantation in group I those without rejection episode in comparison with group II with a rejection episode. (bvsalud.org)
  • In late 1980, he was part of the team that first introduced the anti-rejection drug cyclosporine for heart transplantation. (wikipedia.org)
  • Alloimmunity and Transplantation integrates basic sciences and clinical research and welcomes submissions going from experimental animal models to clinical studies. (frontiersin.org)
  • The research group is also working on clinical issues related kidney, liver and pancreas transplantation. (uio.no)
  • Our main goals in clinical transplantation surgery are to improve the prognosis and patient survival in kidney, liver and pancreas recipients and to optimize graft function. (uio.no)
  • The grants are two of 19 Stem Cell Transplantation Immunology awards totaling $25 million that were approved at the June 23 meeting of CIRM's Independent Citizens' Oversight Committee to fund work that translates basic research into clinical cures. (ucsd.edu)
  • Simultaneously, we are using these new biologic understandings to rationally improve transplantation approaches through the direct translation in early-phase clinical trials. (cancer.gov)
  • Discovery to clinical applications of Regulatory T cells in autoimmunity and transplantationsis hosted by the BSI West Midlands Immunology Group in conjunction with the University of Birmingham. (immunology.org)
  • Equine Clinical Immunology offers comprehensive information on equine immunological disorders. (wiley.com)
  • Dr. Helen Su, chief of the Human Immunological Diseases Section in the Laboratory of Clinical Immunology and Microbiology, received the Society of Pediatric Research E. Mead Johnson Award for her research defining molecular mechanisms of inherited human immunological diseases, understanding the function of the DOCK8 gene in health and human disease, and elucidating innate immunoregulatory mechanisms for control of respiratory virus infections in humans. (nih.gov)
  • Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. (elsevier.com)
  • aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results on all aspects of Clinical Immunology and Health Sciences. (waset.org)
  • Also, high quality research contributions describing original and unpublished results of conceptual, constructive, empirical, experimental, or theoretical work in all areas of Clinical Immunology and Health Sciences are cordially invited for presentation at the conference. (waset.org)
  • ICCIHS 2022 has teamed up with the Special Journal Issue on Clinical Immunology and Health Sciences . (waset.org)
  • Within his clinical expertise he has direct involvement in the clinical care, and pre and post operative management of the pediatric cardiac transplant patients at The Children's Hospital with particular expertise in transplantation for the infant population. (ucdenver.edu)
  • Journal of Allergy and Clinical Immunology 2017, 141 (1), 445-448.e4. (ncl.ac.uk)
  • As staff associate, he was responsible for both clinical activity in cardiac surgery in the Clinic of Surgery of the National Heart Lung and Blood Institute and for intramural research programs addressing cardiac physiology and heart transplantation. (wikipedia.org)
  • On reflection of the worldwide transplants, Stinson stated Many centers took up clinical transplantation without the laboratory experience or profound support in clinically related areas such as immunosuppression. (wikipedia.org)
  • European experience of bone-marrow transplantation for severe combined immunodeficiency. (jamanetwork.com)
  • Long-term immune reconstitution and outcome after HLA-nonidentical T-cell-depleted bone marrow transplantation for severe combined immunodeficiency: a European retrospective study of 116 patients. (jamanetwork.com)
  • Matched unrelated bone marrow transplantation for combined immunodeficiency. (jamanetwork.com)
  • Long-term chimerism and B-cell function after bone marrow transplantation in patients with severe combined immunodeficiency with B cells: a single-center study of 22 patients. (jamanetwork.com)
  • Unrelated donor bone marrow transplantation for correction of lethal congenital immunodeficiencies. (jamanetwork.com)
  • Influence of severe combined immunodeficiency phenotype on the outcome of HLA non-identical, T-cell-depleted bone marrow transplantation: a retrospective European survey from the European Group for Bone Marrow Transplantation and the European Society for Immunodeficiency. (jamanetwork.com)
  • Physician-scientist Marcel R. M. van den Brink studies the immunology of bone marrow transplantation with a particular focus on intestinal microbiome and strategies to enhance thymus and immune reconstitution. (mskcc.org)
  • In 1981, he was a founding member of the International Society for Heart and Lung Transplantation (ISHLT) and chaired their first international programme. (wikipedia.org)
  • The MHC was discovered during tumor transplantation studies in mice by Peter Gorer in 1937 at the Lister Institute, and was so named because "histo" stands for tissue in medical terminology. (encyclopedia.com)
  • He then completed a surgical oncology and tumor immunology fellowship at the Surgery Branch of the National Cancer Institute (NCI). (cancer.gov)
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Jan 2017. (upenn.edu)
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Oct 2016. (upenn.edu)
  • All manuscripts must be submitted directly to the section Alloimmunity and Transplantation, where they are peer-reviewed by the Associate and Review Editors of the specialty section. (frontiersin.org)
  • Articles published in the section Alloimmunity and Transplantation will benefit from the Frontiers impact and tiering system after online publication. (frontiersin.org)
  • RESEARCH DESCRIPTION The Division of Transplantation Immunology and Mucosal Biology has a strong interest in basic biological mechanisms that determine the balance between health and disease. (gradschools.com)
  • Peripheral Blood Gene Expression Changes Associated with Primary Graft Dysfunction after Lung Transplantation. (upenn.edu)
  • Massive donor transfusion potentially increases recipient mortality after lung transplantation. (upenn.edu)
  • Journal of Heart & Lung Transplantation 35(4): 500-507, Apr. (upenn.edu)
  • Dr. Nicolls has a special interest in how the immune system contributes to vascular disease and has a basic science laboratory which focuses on lung transplantation, pulmonary hypertension, and lymphedema. (stanford.edu)
  • Lemström K. Heart transplantation and mechanical circulatory support and lung and heart-lung transplantation. (helsinki.fi)
  • Jon Austyn has over 25 years research experience of dendritic cell immunobiology, particularly as applied to transplantation, infectious diseases and more recently cancer. (wiley-vch.de)
  • Matching of blood group antigens other than A, B, AB, O is not critical for transplantation, because they are expressed only on red Blood cells. (preservearticles.com)
  • As recognition of foreign cells by recipient T cells is associated with MHC antigens of foreign cells, knowledge about MHC is essential to understand transplantation reactions. (preservearticles.com)
  • Beside transplantation and blood transfusion, pregnancy can induce an immune response to mismatched HLA-antigens [ 3 ]. (wiley.com)
  • They study the role of T cell mediated innate immune responses in the development of intimal proliferative lesions of the type that are typically found in over 30% of heart transplantation patients after the first three years post-transplantation. (uab.edu)
  • The use of post-transplantation cyclophosphamide (PTCy) as GVHD prophylaxis recently has revolutionized the HCT field by making HCT available to nearly all patients and effectively preventing both severe acute and chronic GVHD. (cancer.gov)
  • Pre & post transplantation assessment and testing for diagnosis of diseases with association to the Human Leukocyte Antigen (HLA). (lalpathlabs.com)
  • Moreover, it is not unusual to fnd patients who developed antibodies post transplantation demonstrating a decrease in antibody titer up to complete elimination of those antibodies. (scifed.com)
  • The results of this investigation showed that the level of immunoglobulin IgG , IgM , IgA and IgE decreased post transplantation due to immunosuppressive drugs . (bvsalud.org)
  • CDS, CD4, CDS T cells count, CD56 NK cells count and CD20 B cells count pre- and post- transplantation did not show any significant differences. (bvsalud.org)
  • Transplantation 2018 (Epub) Notes: doi: 10.1097/TP.0000000000002056. (upenn.edu)
  • Liver Transplantation Feb. 2018 Notes: accepted for publication. (upenn.edu)
  • American Journal of Transplantation 18(2): 492-503, Feb. 2018 Notes: (Epub Oct. 9, 2017). (upenn.edu)
  • Transplantation 102(1): 70-78, Jan. 2018 Notes: (Epub May 2017). (upenn.edu)
  • Frontiers in Immunology 2018, 8 , 1844. (ncl.ac.uk)
  • Frontiers in Immunology 2018, 9 , 755. (ncl.ac.uk)
  • Immunology 2018, 153 (1), 51-59. (ncl.ac.uk)
  • We are recruiting a highly motivated Postdoctoral Research Fellow to study the biology of graft-versus-host disease (GVHD) and mechanisms of its prevention after allogeneic hematopoietic cell transplantation (HCT). (cancer.gov)
  • The use of such a high-tech procedure as hematopoietic stem cell transplantation (HSCT) significantly increases the chance of children's recovery or in some very severe cases extends the period of remission. (oncology.by)
  • The transplantation Department is designed for 8 patients and performs all types of hematopoietic and mesenchymal stem cell transplants (allogeneic, autologous, partially compatible, haploidentical). (oncology.by)
  • Impact of HLA matching on outcome of hematopoietic stem cell transplantation in children with inherited diseases: a single-center comparative analysis of genoidentical, haploidentical or unrelated donors. (jamanetwork.com)
  • Graft dysfunction and delayed immune reconstitution following haploidentical peripheral blood hematopoietic stem cell transplantation. (jamanetwork.com)
  • Physician-scientist Richard O'Reilly investigates the genetic disparities and cellular interactions between donor and host that affect allogeneic hematopoietic cell transplantation. (mskcc.org)
  • The CCTI has been selected to receive the International Transplantation Science Mentee-Mentor Award 2017 given by The Transplantation Society (TTS). (columbia.edu)
  • American Journal of Transplantation Aug. 14 2017 (Epub) Notes: doi: 10.1111/ajt.14462. (upenn.edu)
  • Frontiers in Immunology 2017, 8 , 1866. (ncl.ac.uk)
  • The biology of tissue transplantation, Paul S. Russell, Anthony P. Monaco. (rpi.edu)
  • The ultimate goal of the research is to get insights into the mechanisms of specific immune response after transplantation of stem cells with the aim to increase their antiinflammatory and therapeutic potential. (cas.cz)
  • Direct allorecognition of intact surface MHC:peptide molecules expressed on donor cells is a process unique to transplantation. (oncologynurseadvisor.com)
  • The donor MHC was derived from allogeneic exosomes, which could induce proinflammatory alloimmune responses even without transplantation. (sciencemag.org)
  • Reconstitution in severe combined immunodeficiency by transplantation of marrow from an unrelated donor. (jamanetwork.com)
  • The results from viral studies re﫿ect an important issue in transplantation.First, during pre-transplant preparation step, it suggests that analysis of the reactivity against the donor HLA of sensitized patients using serum alone may be insufficient for optimal HLA matching. (scifed.com)
  • Second,after secondary transplantation in sensitized patients, denovo donor specific antibodies (DSA) associated with unpredicted or multiple HLA specifcities may be arising from memory B-cell precursors. (scifed.com)
  • The selection of appropriate candidates, optimizing donor selection, the use of an optimized protocol for islet cell extraction, and immunosuppression therapy have been proved to be the key criteria for a favorable outcome in islet transplantation. (springer.com)
  • Are Liver Cystic Lesions after Islet Transplantation Caused by Streptozotocine? (diabetesjournals.org)
  • Who Should Be Considered for Islet Transplantation Alone? (springer.com)
  • Islet transplantation offers an alternative therapeutic option for these patients, in whom these conventional approaches have been unsuccessful. (springer.com)
  • Islet transplantation can completely resolve hypoglycemia and near-normalize glucose levels, achieving insulin independence for a limited period of time in up to 40% of patients. (springer.com)
  • The purpose of the CIRM Stem Cell Transplantation Immunology Awards is to fund transformative research leading to the development of immune tolerance of pluripotent stem cell derivatives and potential correction of autoimmunity. (ca.gov)
  • Though both responses (innate and adaptive) are important in transplantation, the majority of treatment modalities in transplantation are directed against the adaptive immune response. (oncologynurseadvisor.com)
  • Immunology is a branch of biology that covers the study of immune systems in all organisms. (immunology.ml)
  • Immunology describes the physical, chemical, and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. (immunology.ml)
  • Acquired defects in the immune defenses occur in transplantation and oncology patients. (mhmedical.com)
  • The ability of children to mount an immune response against alloantigens in the transplantation setting will be discussed. (mhmedical.com)
  • Cavazzana-Calvo M, Andre-Schmutz I, Hacein-Bey-Abina S, Bensoussan D, Le Deist F, Fischer A. Improving immune reconstitution while preventing graft-versus-host disease in allogeneic stem cell transplantation. (jamanetwork.com)
  • Immune parameters including lymphocytes subpopulations [by flowcytometry] and immunoglobulin classes [ IgM , IgG , IgA and IgE by nephlometric assay] before and 45 days after transplantation were determined. (bvsalud.org)
  • We are specifically examining the contribution of inflammation to the development of vascular injury in transplantation, pulmonary hypertension and lymphedema. (stanford.edu)
  • Evidence of pulmonary vascular disease after heart transplantation for Fontan circulation failure. (ucdenver.edu)
  • Mechanical Limitation of Pulmonary Blood Flow Facilitates Heart Transplantation in Older Infants with Hypoplastic Left Heart Syndrome. (ucdenver.edu)
  • The Division is home to the MRC Centre for Transplantation which brings together research across disciplines including genetics, protein and cell therapeutics, imaging science and stem cell biology. (gradschools.com)
  • Research within the Cancer Institute is varied and entails various disciplines such as molecular and cellular biology, cancer genetics, immunology, genetic engineering, cancer therapeutics and bioinformatics. (ucl.ac.uk)
  • The National Advisory Allergy and Infectious Diseases Council convened in closed session to consider applications in allergy and immunology, microbiology and infectious diseases, and AIDS. (nih.gov)
  • Based on the notion that outcomes in human transplantation were unacceptable due to the requirement for long-term pharmacologic immunosuppression, and building on significant preclinical data, investigators at Massachusetts General Hospital attempted to achieve tolerance in humans. (frontiersin.org)
  • SAM inhibited apoptosis of intra-hepatic and extra-hepatic biliary epithelial cells after liver transplantation. (deepdyve.com)
  • The main goals in experimental immunology is to map and identify new therapeutic targets. (uio.no)
  • Therapeutic approaches for transplantation. (ox.ac.uk)
  • Section for nephrology, Dept. of transplantation medicine, OUS. (uio.no)
  • Cell-based therapies have been studied extensively in the context of transplantation tolerance induction. (frontiersin.org)
  • Cell-based therapies lie at the root of transplantation tolerance induction protocols. (frontiersin.org)
  • Regulation and privilege in transplantation tolerance. (ox.ac.uk)
  • Immunology Program Chair Alexander Rudensky focuses on immunological tolerance and the differentiation and function of T cells. (mskcc.org)
  • For patients who received multiple transplants, survival was calculated from the date of the last transplantation. (jamanetwork.com)
  • Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968-99. (jamanetwork.com)
  • American Journal of Transplantation 16(9): 2598-2611, Sept. 2016 Notes: (Epub Apr. (upenn.edu)
  • Nature Immunology 17(6): 656-665, June 2016 Notes: (Epub Apr. (upenn.edu)
  • The most sensitive type of transplantation with respect to this are those involving the bone marrow (Haematopoietic Stem Cell Transplantation) HLA matching is an absolute requirement so its use is limited to HLA-matched donors, usually a brother or sister. (encyclopedia.com)
  • It additionally analyzes the result of transplantation of cadaver organs from older donors and marginal, non-heart beating donors. (sk2arch.com)
  • S-Adenosylmethionine SAM attenuated intra-hepatic and extra-hepatic bile duct injury after liver transplantation. (deepdyve.com)
  • SAM depressed oxidative stress and inflammatory response in bile duct tissues after liver transplantation. (deepdyve.com)
  • Home » Experimental Transplantation and Immunology Branch » Christian S. Hinrichs, M.D. (cancer.gov)
  • This requires an understanding of basic immunology, the mechanism of action and side effects of immunosuppressive medications, and a thorough immunologic risk assessment. (oncologynurseadvisor.com)
  • This first involves transplantation of retinal pigment epithelial (RPE) cells as a treatment for age-related macular degeneration (AMD), which is the leading cause of blindness in people over the age of 65 in this country. (uab.edu)
  • Transplantation refers to transfer of living cells, tissues and organs from one part of the body to another from one individual to another. (conferenceseries.com)
  • My work so far has helped in clearly defining the role of chemokines in inflammation with particular relevance to transplantation. (ncl.ac.uk)
  • Submission of an application for the Stem Cell Transplantation Immunology RFA involves a two-step process in which an applicant first submits a Letter of Intent (LOI). (ca.gov)
  • The application for the Stem Cell Transplantation immunology Award consists of four parts: Part A: Application Information Form, Part B: Stem Cell Transplantation Immunology Award Research Proposal, Part C: Biographical Sketches for Key Personnel, and Part D: Related Business Entities Disclosure Form. (ca.gov)
  • All four parts of the application for Stem Cell Transplantation Awards must be submitted together and received by CIRM no later than 5:00pm PST on January 26, 2010 , in both electronic form and in hard copy (a signed original and five copies). (ca.gov)
  • First systematic study of transplantation was reported in 1908 by Alexis Carrel. (preservearticles.com)
  • He introduced two ad hoc Council members: Dr. Rafi Ahmed, Charles Howard Candler Professor of Microbiology and Immunology and director of the Emory Vaccine Center, and Dr. James Crowe, Jr., professor of pediatrics and pathology, microbiology and immunology, and director of the Vanderbilt Vaccine Center. (nih.gov)