Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.
The transference of a part of or an entire liver from one human or animal to another.
A general term referring to the learning of some particular response.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The transference of a kidney from one human or animal to another.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Reflex closure of the eyelid occurring as a result of classical conditioning.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Transplantation of an individual's own tissue from one site to another site.
The transference of a heart from one human or animal to another.
The transference of either one or both of the lungs from one human or animal to another.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The affective response to an actual current external danger which subsides with the elimination of the threatening condition.
Transference of an organ between individuals of the same species or between individuals of different species.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced.
The transference of a pancreas from one human or animal to another.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
Brief closing of the eyelids by involuntary normal periodic closing, as a protective measure, or by voluntary action.
Elements of limited time intervals, contributing to particular results or situations.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
The principle that items experienced together enter into a connection, so that one tends to reinstate the other.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
An induced response to threatening stimuli characterized by the cessation of body movements, except for those that are involved with BREATHING, and the maintenance of an immobile POSTURE.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
The return of a sign, symptom, or disease after a remission.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
The maintenance of certain aspects of the environment within a defined space to facilitate the function of that space; aspects controlled include air temperature and motion, radiant heat level, moisture, and concentration of pollutants such as dust, microorganisms, and gases. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.
The procedure of presenting the conditioned stimulus without REINFORCEMENT to an organism previously conditioned. It refers also to the diminution of a conditioned response resulting from this procedure.
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A response to a cue that is instrumental in avoiding a noxious experience.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Transplantation between animals of different species.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Prospective patient listings for appointments or treatments.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The observable response an animal makes to any situation.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Partial or total replacement of the CORNEA from one human or animal to another.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Use of sound to elicit a response in the nervous system.
A change in electrical resistance of the skin, occurring in emotion and in certain other conditions.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
A dead body, usually a human body.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Pathological processes of the LIVER.
Animal searching behavior. The variable introductory phase of an instinctive behavior pattern or sequence, e.g., looking for food, or sequential courtship patterns prior to mating.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Disease having a short and relatively severe course.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Immunological rejection of tumor tissue/cells following bone marrow transplantation.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
Signals for an action; that specific portion of a perceptual field or pattern of stimuli to which a subject has learned to respond.
Providers of tissues for transplant to non-related individuals.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
Progenitor cells from which all blood cells derive.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
A complex involuntary response to an unexpected strong stimulus usually auditory in nature.
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.
Immunological rejection of leukemia cells following bone marrow transplantation.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
The volatile portions of substances perceptible by the sense of smell. (Grant & Hackh's Chemical Dictionary, 5th ed)
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Use of electric potential or currents to elicit biological responses.
The transference of a complete HAND, as a composite of many tissue types, from one individual to another.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
The period following a surgical operation.
Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A fold of the mucous membrane of the CONJUNCTIVA in many animals. At rest, it is hidden in the medial canthus. It can extend to cover part or all of the cornea to help clean the CORNEA.
Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.
Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.
Disorders of the blood and blood forming tissues.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
The strengthening of a conditioned response.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
The persistence to perform a learned behavior (facts or experiences) after an interval has elapsed in which there has been no performance or practice of the behavior.
An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Four clusters of neurons located deep within the WHITE MATTER of the CEREBELLUM, which are the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
An individual that contains cell populations derived from different zygotes.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
The induction of prolonged survival and growth of allografts of either tumors or normal tissues which would ordinarily be rejected. It may be induced passively by introducing graft-specific antibodies from previously immunized donors, which bind to the graft's surface antigens, masking them from recognition by T-cells; or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity.
A monosynaptic reflex elicited by stimulating a nerve, particularly the tibial nerve, with an electric shock.
The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Tissues, cells, or organs transplanted between genetically different individuals of the same species.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
Antibodies produced by a single clone of cells.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
A genus of dextrally coiled freshwater snails that includes some species of importance as intermediate hosts of parasitic flukes.
Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.
A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
Remembrance of information from 3 or more years previously.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
The relationship between the dose of an administered drug and the response of the organism to the drug.
An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure.
The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.
The time from the onset of a stimulus until a response is observed.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Tumors or cancer of the LIVER.

Early harvest and late transplantation as an effective therapeutic strategy in multiple myeloma. (1/1881)

Transplantation after high-dose chemotherapy prolongs survival in patients with multiple myeloma compared with standard therapy. It is unclear whether the optimal timing of transplantation is immediately after induction chemotherapy or whether stem cells may be cryopreserved for transplantation at subsequent progression or relapse. In this study, stem cells were collected within 6 months of diagnosis, followed by transplantation only at progression of myeloma. One hundred and eighteen patients with multiple myeloma had stem cells collected and cryopreserved. Eleven had transplants early in the disease after they demonstrated failure to respond to primary therapy. The remaining 107 were eligible for transplants when there was evidence of progressive disease. Of the 118 patients, 67 had transplants, nine died of progressive disease before transplantation, and 42 remain alive in plateau phase. The median survival of the group is 58.5 months; 67 are alive. Serum beta2-microglobulin, bone marrow labeling index (S phase), and hemoglobin level predicted overall survival (P < 0.006, P < 0.001, and P < 0.01, respectively). We conclude that early cryopreservation of blood stem cells followed by transplantation at progression is a feasible approach to therapy in patients with myeloma. The underlying biology of the disease has a greater impact on survival than the timing of transplantation. A prospective randomized trial is required to answer definitively the question of the optimal timing of blood cell transplantation.  (+info)

High-dose therapy with autologous or allogeneic transplantation as salvage therapy for small cleaved cell lymphoma of follicular center cell origin. (2/1881)

Between 1985 and 1996, 51 patients with relapsed or refractory small cleaved cell lymphoma (SCCL) received high-dose chemotherapy +/- TBI in conjunction with autologous (ABMT) (36 patients) or allogeneic transplantation (15 patients). Patients were eligible for ABMT if the bone marrow biopsy done prior to the planned transplant did not reveal microscopic involvement with SCCL. Patients receiving ABMT had a median age of 48 years, had received a median of 2.5 chemotherapy regimens prior to transplantation, and were transplanted a median of 35.5 months from diagnosis. Among patients receiving ABMT, 5 year actuarial survival was 56+/-11%. Median survival was 126+ months, and median survival from diagnosis was 191 months. Univariate and multivariate analysis identified sensitive disease as the best predictor of a favorable response. Five-year actuarial survival was 66+/-12% for patients with sensitive disease at the time of transplant as compared to 29+/-17% for patients with resistant disease, P = 0.015. Median survival in patients with sensitive disease at the time of ABMT was 126+ months. By univariate analysis, survival was significantly better for patients receiving ABMT as compared to patients receiving allogeneic transplants. Median survival following allogeneic transplantation was 5 months; 5 year actuarial survival was 15+/-13%. In a multivariate analysis, which considered autologous vs allogeneic transplantation, sensitive vs resistant disease, <3 vs > or = 3 prior treatments, and prior bone marrow involvement, allogeneic transplantation was significantly associated with poor survival. Treatment-related mortality occurred in eight of 15 patients receiving allogeneic transplantation and limited the effectiveness of this therapy. High-dose therapy in conjunction with ABMT is effective therapy for patients with SCCL whose disease is sensitive to chemotherapy and whose marrows are microscopically free of disease. Because of possible selection bias, it has not been proven that this approach increases survival in these patients. Treatment-related mortality limits the effectiveness of allogeneic transplantation in SCCL.  (+info)

Autologous transplantation of chemotherapy-purged PBSC collections from high-risk leukemia patients: a pilot study. (3/1881)

We have recently demonstrated that the combination of the alkylating agent nitrogen mustard (NM) and etoposide (VP-16) is capable of eliminating, ex vivo, leukemic cells contaminating PBSC collections and this is associated with a significant recovery of primitive and committed hematopoietic progenitor cells. Based on these data a pilot study on autologous transplantation of NM/VP-16 purged PBSC for high-risk leukemic patients was recently initiated. Twelve patients (seven females and five males) with a median age of 46 years (range 18-57) have been treated. Two patients had acute myeloblastic leukemia (AML) resistant to conventional induction treatment, four patients had secondary AML in I complete remission (CR), one patient was in II CR after failing a previous autologous BM transplantation, while two additional AML individuals were in I CR achieved after three or more cycles of induction treatment. Two patients with high-risk acute lymphoblastic leukemia (ALL) in I CR and one patient with mantle cell lymphoma and leukemic dissemination were also included. Eight patients showed karyotypic abnormalities associated with a poor clinical outcome. The mobilizing regimens included cytosine arabinoside and mitoxantrone with (n = 6) or without fludarabine (n = 3) followed by subcutaneous administration of G-CSF (5 microg/kg/day until the completion of PBSC collection) and G-CSF alone (n = 3) (15 microg/kg/day). A median of two aphereses (range 1-3) allowed the collection of 7.2 x 10(8) TNC/kg (range 3.4-11.5), 5 x 10(6) CD34+ cells/kg (range 2.1-15.3) and 9.2 x 10(4) CFU-GM/kg (0.3-236). PBSC were treated with a constant dose of 20 microg of VP-16/ml and a median individual-adjusted dose (survival < or = 5% of steady-state BM CFU-GM) of NM of 0.7 microg/ml (range 0.25-1.25). Eleven patients were reinfused after busulfan (16 mg/kg) and Cy (120 mg/kg) conditioning with a median residual dose of 0.3 x 10(4) CFU-GM/kg (0-11.5). The median time to neutrophil engraftment (>0.5 x 10(9)/l) for evaluable patients was 25 days (range 12-59); the median time to platelet transfusion independence (>20 and >50 x 10(9)/l) was 40 days (18-95) and 69 days (29-235), respectively. Hospital discharge occurred at a median of 25 days (18-58) after stem cell reinfusion. Four individuals are alive in CR (n = 3) or with residual nodal disease (n = 1 lymphoma patient) with a follow-up of 32, 26, 3 and 14 months, respectively. Seven patients died due to disease progression or relapse (n = 5) or extrahematological transplant toxicity (n = 2). Our data suggest that pharmacological purging of leukapheresis collections of leukemic patients at high-risk of relapse is feasible and ex vivo treated cells reconstitute autologous hematopoiesis.  (+info)

Ultrasound B-mode changes in the uterus and ovaries and Doppler changes in the uterus after total body irradiation and allogeneic bone marrow transplantation in childhood. (4/1881)

Internal genitalia and uterine blood flow were assessed by ultrasound in 12 females 4.0-10.9 years after total body irradiation and allogeneic bone marrow transplantation for childhood leukaemia or lymphoma. Median age of the participants was 12.7 years (range 6.1-17.6) at bone marrow transplantation and 21.5 years (11.6-25.6) at the follow-up study. At follow-up all had entered puberty and 11/12 females had experienced the menarche. Eight females received sex steroid replacement therapy, three had spontaneous pubertal development and one woman experienced symptoms of estrogen deficiency. Median uterine and ovarian volumes were significantly reduced to -2.6 standard deviation scores (SDS) (-6.3 to -0.6), P = 0.002, and -2.6 SDS (-4.8 to -0.5), P = 0.002, respectively, compared with normal controls. Follicles were only detectable in two individuals. Uterine blood flow was impaired, as a systolic blood flow could be measured in 6/9 individuals, and a diastolic blood flow in 1/9 females. Our results indicate that the prescribed dosage of hormone replacement therapy, which was sufficient to induce bleeding and suppress other stigmata of premature menopause, was inadequate to generate normal uterine growth. In order to achieve uterine growth higher doses of hormone replacement therapy may be required. Our results confirm pelvic ultrasound as a reliable tool for investigation of internal female genitalia; however, in an infertility setting further tests are indicated.  (+info)

Antiemetic efficacy of granisetron plus dexamethasone in bone marrow transplant patients receiving chemotherapy and total body irradiation. (5/1881)

Few trials exist regarding the antiemetic efficacy of granisetron in bone marrow transplant (BMT) recipients conditioned with high-dose chemotherapy and total body irradiation (TBI). In this single-center, open-label, prospective, trial, the antiemetic efficacy and safety of granisetron plus dexamethasone were evaluated in 26 patients conditioned with cyclophosphamide-containing regimens (the majority receiving 60 mg/kg per day on 2 consecutive days), and TBI (12 Gy divided over 4 days). Daily intravenous doses of granisetron 1 mg plus dexamethasone 10 mg were given 30 min prior to chemotherapy or radiation, and continued for 24 h after the last conditioning treatment for a median of 6 days (range 3-9). Emetic control was defined by the number of emetic episodes occurring within a 24 h period, or the requirement for rescue medication for nausea or vomiting. A total of 25 patients completed 186 evaluable treatment days. Response (emetic control by treatment days) was complete in 50% of patients, major in 48%, minor in 2%, and there were no failures. Adverse effects were minor, with diarrhea (15%), headache (14%), and constipation (11%) reported most often. Based on these results, the antiemetic regimen of granisetron plus dexamethasone appears effective and well tolerated during BMT conditioning with high-dose cyclophosphamide and TBI.  (+info)

Adenovirus infection after pediatric bone marrow transplantation. (6/1881)

Retrospective analysis of 206 patients undergoing 215 consecutive bone marrow transplants (BMT) at St Jude Children's Research Hospital between November 1990 and December 1994 identified 6% (seven male, six female) with adenovirus infection. The affected patients had a median age of 7.9 years (range 3-24 years) at time of transplantation. Although transplants were performed for hematologic malignancies, solid tumors or nonmalignant conditions, only patients with hematologic malignancies had adenoviral infections. Adenovirus was first detected at a median of 54 days (range -4 to +333) after BMT. Adenovirus developed in eight of 69 (11.6%) patients receiving grafts from matched unrelated or mismatched related donors, in four of 52 (7.7%) receiving grafts from HLA-matched siblings, and in one of 93 (1.1%) receiving autografts. The most common manifestation of adenovirus infection was hemorrhagic cystitis, followed by gastroenteritis, pneumonitis and liver failure. The incidence of adenovirus infection in pediatric BMT patients at our institution is similar to that reported in adult patients. Using univariate analysis, use of total body irradiation and type of bone marrow graft were significant risk factors for adenovirus infection. Only use of total body irradiation remained as a factor on multiple logistic regression analysis.  (+info)

Fungal prophylaxis by reduction of fungal colonization by oral administration of bovine anti-Candida antibodies in bone marrow transplant recipients. (7/1881)

Candida overgrowth and invasion constitute a serious threat with a high mortality in BMT recipients. Currently available topical antifungal prophylaxis is largely ineffective, and as resistance to existing, absorbable drugs for systemic use is rapidly developing, new forms of therapy are needed. We investigated the effect of oral treatment of BMT recipients with a bovine immunoglobulin product derived from animals immunized against several Candida species. The natural Candida colonization was first followed in 19 patients to establish the colonization pattern. Half of the patients were found to be colonized prior to transplantation and altogether 72% were colonized at some point during follow-up. Those with a high pre-transplant concentration of Candida in saliva (>100 CFU/ml) remained colonized throughout the BMT treatment period. The therapeutic effect was monitored in two other patient groups. The first group consisted of nine patients, where, due to a low number of primary colonized patients, response in colonized patients was suggestive of a therapeutic effect. In the second group, 10 patients with a high level of colonization (>100 CFU/ml) were given 10 g daily of the product in three divided doses. The results suggest a treatment-related reduction in Candida colonization in a majority (7/10) of patients and one patient became completely negative. As no adverse effects were noted, our findings encourage additional studies in immunocompromised, transplant patients.  (+info)

Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy. (8/1881)

A patient with a stage IV mantle cell lymphoma (according to the REAL classification) was treated with high-dose chemotherapy and autologous bone marrow transplantation. One year later while on alpha-interferon immunotherapy she suffered from progressive loss of short-term memory and reported difficulties in recognizing objects. Magnetic resonance imaging (MRI) showed a vast ring-enhancing lesion of the left postcentral parietal area. Serial stereotactic biopsies disclosed progressive multifocal leukoencephalopathy without JC-virus in the cerebrospinal fluid. Therapy with subcutaneous interleukin-2 (IL-2) every other day and intrathecal cytarabine once a week was started. After 4 weeks the patient refused further treatment. Nevertheless her condition improved over the next 8 months and MRI scans showed a marked improvement in the lesions.  (+info)

Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis. 2013 Jun 01; 207(11):1694-702 ...
Our clinical investigations demonstrate, that nonmyeloablative stem cell transplantation (NST) is a novel therapeutic option in patients with high-risk ALL or AML. NST can be administered to patients eligible for allogeneic stem cell transplantation with contraindications against high-dose radio- and chemotherapy (standard SCT). After NST, infections and late onset acute graft-versus-host disease (GvHD) frequently occurred, but transplant-related mortality was low in contrast to standard SCT. Leukemia-free survival and overall survival were similar after NST and standard SCT. A higher relapse rate after NST was balanced by a higher transplant-related mortality after standard SCT. The conditioning regimen itself had no relevant impact on survival. Sequential chimerism analyses of leukocyte subpopulations resulted in early diagnosis of mixed chimerism, which proved to be predictive for later relapses. Stable mixed chimerism was not established in these patients. Adoptive immunotherapy in patients, ...
Allogeneic hematopoietic cell transplantation (HCT) using reduced-intensity conditioning (RIC) regimens is a potentially curative treatment for patients (patients) with myelofibrosis
Johan Törlén, Olle Ringdén, Jennifer Le Rademacher, Minoo Batiwalla, Junfang Chen, Tom Erkers, Vincent Ho, Partow Kebriaei, Carolyn Keever-Taylor, Tamila Kindwall-Keller, Hillard M. Lazarus, Mary J. Laughlin, Michael Lill, Tracey OBrien, Miguel Angel Perales, Vanderson Rocha, Bipin N. Savani, David Szwajcer, David Valcarcel, Mary Eapen ...
Wiskott-Aldrich syndrome (WAS) is an inherited immunodeficiency caused by mutations in the gene encoding WASP that is treated with hematopoietic stem/progenitor cell (HSPC) transplantation. Infusion of autologous HSPCs modified ex vivo by gene therapy is an alternative approach when matched donors are unavailable. Following reduced-intensity conditioning regimen, three WAS patients were infused with autologous HSPCs genetically corrected by […]. ...
If transplantation using mismatched unrelated donors or non-first-degree relatives could be performed with an acceptable toxicity profile, an important unmet need would be served. Towards this goal, the current study extends our platform of nonmyeloablative, partially HLA-mismatched BMT to the use of such donors, investigating up to several postgrafting immunosuppression regimens that incorporate high-dose Cy. Of central interest is the incorporation of sirolimus into this postgrafting immunosuppression regimen. The primary goal is to identify a transplant regimen associated with acceptable rates of severe acute GVHD and NRM by Day 100 ...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
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The study aimed to evaluate the impact of myeloablative (MAC) versus reduced intensity conditioning (RIC) regimen on allo-HSCT outcomes in patients with t-AML
TY - JOUR. T1 - Long-Term Follow-Up after Reduced-Intensity Conditioning and Stem Cell Transplantation for Childhood Nonmalignant Disorders. AU - Madden, Lisa M.. AU - Hayashi, Robert J.. AU - Chan, Ka Wah. AU - Pulsipher, Michael A.. AU - Douglas, Dorothea. AU - Hale, Gregory A.. AU - Chaudhury, Sonali. AU - Haut, Paul. AU - Kasow, Kimberly A.. AU - Gilman, Andrew L.. AU - Murray, Lisa M.. AU - Shenoy, Shalini. PY - 2016/8/1. Y1 - 2016/8/1. N2 - Reduced-intensity conditioning (RIC) before hematopoietic stem cell transplantation (HCT) in children could result in fewer complications during follow-up compared with myeloablative regimens. Hence, many RIC regimens are under investigation, but long-term follow-up is essential. We describe late follow-up beyond 2 years post-HCT in 43 children with nonmalignant disorders who underwent related or unrelated donor (56%) HCT on a multicenter study using a RIC regimen (alemtuzumab, fludarabine, and melphalan) followed by bone marrow (n = 30), peripheral ...
BM failure (BMF) is a major and frequent complication of dyskeratosis congenita (DKC). Allogeneic hematopoietic SCT (allo-HSCT) represents the only curative treatment for BMF associated with this condition. Transplant-related morbidity-mortality is common especially after myeloablative conditioning regimens. Herein, we report nine cases of patients with DKC who received an allo-SCT at five different member centers within the Eastern Mediterranean Blood and Marrow Transplantation Registry. Between October 1992 and February 2011, nine DKC patients (male, 7 and female, 2), with a median age at transplantation of 19.1 (4.9-31.1) years, underwent an allo-HSCT from HLA-matched, morphologically normal-related donors (100percent). Preparative regimens varied according to different centers, but was reduced intensity conditioning (RIC) in eight patients. Graft source was unstimulated BM in five cases (56percent) and G-CSF-mobilized PBSCs in four (44percent) cases. The median stem cell dose was 6.79 ...
ContextA minimally toxic nonmyeloablative regimen was developed for allogeneic hematopoietic cell transplantation (HCT) to treat patients with advanced hematolo
In this multicenter retrospective study, the outcomes of 836 patients with myelodysplastic syndrome (MDS) who underwent transplantation with a human leukocyte antigen (HLA)-identical sibling donor were analyzed according to 2 types of conditioning: reduced-intensity conditioning (RIC) in 215 patients, and standard myeloablative (or high-dose) conditioning (SMC) in 621 patients. In multivariate analysis, the 3-year relapse rate was significantly increased after RIC (hazard ratio [HR], 1.64; 95% confidence interval [95% CI], 1.2-2.2; P = .001), but the 3-year nonrelapse mortality (NRM) rate was decreased in the RIC group (HR, 0.61; 95% CI, 0.41-0.91; P = .015). The 3-year probabilities of progression-free and overall survivals were similar in both groups (39% after SMC vs 33% in RIC; multivariate P = .9; and 45% vs 41%, respectively; P = .8). In conclusion, the lower 3-year NRM after RIC is encouraging, since these patients were older (age > 50 years in 73% RIC vs 28% in SMC, P < .001) and ...
The use of myeloablative conditioning (MAC) in umbilical cord blood transplantation (UCBT) has been associated with high nonrelapse mortality (NRM) in patients aged ,40 years, especially those having a high HLA disparity, thus limiting wider applications. We hypothesized that the NRM advantage of reduced-intensity conditioning (RIC) and higher graft-versus-leukemia effect associated with greater HLA disparities would expand its use for patients (aged 40 to 60 years) without compromising efficacy and compared outcomes between RIC and MAC regimens. In total, 288 patients aged 40 to 60 years, with de novo acute myeloid leukemia, receiving UCBT with at least 2 HLA mismatches with RIC (n = 166) or MAC (n = 122) regimens were included. As compared to RIC, the MAC cohort included relatively younger patients, having received more single UCBT, with lower total nucleated cell counts and more in vivo T cell depletion. Median time to neutrophil engraftment, infections (bacterial, viral, and fungal), and ...
Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic ...
The initial trials of reduced intensity allogeneic hematopoietic cell transplantation regimens for metastatic renal cell carcinoma have generated considerable interest because responses were observed in patients who had experienced progressive disease after conventional immunotherapy (13, 14, 15 , 17 , 18) , and some of these responses have been durable for ,4 years (46) . However, despite the use of reduced intensity conditioning regimens, the management of conditioning-related toxicity generally required inpatient care, and treatment-related complications have been responsible for deaths in 11 to 33% of patients treated in this fashion (13, 14, 15, 16, 17 , 47) . The low toxicity of the fludarabine/total body irradiation conditioning regimen combined with posttransplant cyclosporine/mycophenolate mofetil has been established in patients with hematologic malignancies (12 , 21 , 23) . This study confirms the limited toxicity of this conditioning regimen in patients with metastatic renal cell ...
Abstract. BACKGROUND: Chronic GVHD is a major determinant of quality of life after allogeneic HCT. Systemic immunosuppressants (IS) are the mainstay of treatme
To test the safety, and efficacy of Fludarabin and TBI combination for myeloablative conditioning for elderly patients with hematological malignancies (phase
Thiotepa-Containing Conditioning Regimens Improve Survival Outcomes in Patients With PCNSL - ASH Annual Meeting, Lymphomas & Lymphoid Neoplasia, Meeting News, On Location - ASH Clinical News
Complete title: A Randomized Phase II Study to Compare the Net Clinical Benefit of Cyclosporine and Sirolimus combined with MMF or Post-Transplant Cyclophosphamide as GVHD Prophylaxis after HLA-Matched or HLA-Mismatched Unrelated G-CSF Mobilized Blood Cell Transplantation using Nonmyeloablative or Reduced Intensity Conditioning for Patients with Hematologic Malignancies: A Multi-Center ...
Die Universität zu Köln ist eine Exzellenzuniversität mit dem klassischen Fächerspektrum einer Volluniversität. Als eine der größen Hochschulen Europas arbeitet sie in Forschung und Lehre auch international auf höchstem Niveau.
Molecular Templates to receive $38 million upfront payment, including equity investment, with potential for additional milestone and royalty payments on future
*Laboratory Findings Prior to the Start of the Preparative Regimen / Infusion: For questions 80 - 97, report all findings within two months prior to the start...
TY - JOUR. T1 - Infectious complications following nonmyeloablative allogeneic hematopoietic stem cell transplantation. AU - Busca, Alessandro. AU - Locatelli, F.. AU - Barbui, A.. AU - Ghisetti, V.. AU - Cirillo, D.. AU - Serra, R.. AU - Audisio, E.. AU - Falda, M.. PY - 2003/9. Y1 - 2003/9. N2 - Nonmyeloablative hematopoietic stem cell transplantation (NST) has been explored in hematological malignancies and solid tumors in an attempt to minimize treatment-related toxicity. Whether this approach is associated with reduced risk of infectious complications is unclear. The aim of the current study was to evaluate the infectious complications in a series of 32 consecutive adult patients who received NSTat our institution. Peripheral blood stem cell grafts (n = 30) or marrow grafts (n = 2) were infused from human leukocyte antibody (HLA)·matched sibling (n = 30), partially matched related (n = 1), or unrelated (n = 1) donors. Neutropenia developed in two-thirds of patients and lasted 16 days. ...
Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted, 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations. © 2006 The Authors.. ...
Reduced intensity conditioning (RIC) regimens have allowed older patients and those with comorbidities to receive hematopoietic cell transplantation (HCT). We analyzed medical costs from the beginning of conditioning to 100 days after HCT for 484 patients and up to 2 years for 311 patients who underwent a RIC HCT at two institutions from January 2008 to December 2010. Multiple linear regression was used to analyze the association between clinical variables, center effect, and costs. Patient and transplant characteristics were comparable between the sites, although differences were seen in pretransplant performance scores. Significant predictors for lower costs for the first 100 days included a diagnosis of lymphoma/myeloma and use of human leukocyte antigen-matched related donors. Grade II-IV acute graft-versus-host disease (GVHD) was associated with higher costs. The overall short-term costs between the two institutions were comparable when adjusted for clinical variables (p = .43). Late costs ...
TY - JOUR. T1 - Rapid immune reconstitution following autologous hematopoietic stem cell transplantation in children. T2 - A single institution experience. AU - Hoepfner, S.. AU - Haut, Paul. AU - OGorman, M.. AU - Kletzel, M.. PY - 2003/2. Y1 - 2003/2. N2 - In this retrospective study, we review the immune reconstitution of children undergoing autologous hematopoietic stem cell transplantation. A total of 125 patients underwent autologous transplantation between 1992 and 2000. The report includes data on 58 patients. Data were not available on the remaining patients who either died before testing or data were not obtained. The parameters evaluated include: (a) immunophenotype by flow cytometry to quantify lymphocyte subpopulations (b) mitogen stimulation assays, and (c) quantitative immunoglobulins. The analysis reveals that CD3+ cells did not reach the normal range during the first year post-transplant. The median percentage of CD4 + cells was below normal up to 6 months post-transplant, ...
TY - JOUR. T1 - Long-term follow-up of reduced-intensity allogeneic hematopoietic stem cell transplantation for refractory or relapsed follicular lymphoma. AU - Ono, Yukako. AU - Mori, Takehiko. AU - Kato, Jun. AU - Yamane, Akiko. AU - Shimizu, Takayuki. AU - Kikuchi, Taku. AU - Kohashi, Sumiko. AU - Okamoto, Shinichiro. PY - 2012/9. Y1 - 2012/9. UR - UR - U2 - 10.1002/ajh.23261. DO - 10.1002/ajh.23261. M3 - Article. C2 - 22674621. AN - SCOPUS:84865355006. VL - 87. SP - 929. EP - 931. JO - American Journal of Hematology. JF - American Journal of Hematology. SN - 0361-8609. IS - 9. ER - ...
The purpose of this study is to evaluate the outcome of imatinib combined with reduced-intensity allogeneic hematopoietic stem cell transplantation versus
TY - JOUR. T1 - Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome. AU - Muramatsu, Hideki. AU - Sakaguchi, Hirotoshi. AU - Taga, Takashi. AU - Tabuchi, Ken. AU - Adachi, Souichi. AU - Inoue, Masami. AU - Kitoh, Toshiyuki. AU - Suminoe, Aiko. AU - Yabe, Hiromasa. AU - Azuma, Eichi. AU - Shioda, Yoko. AU - Ogawa, Atsushi. AU - Kinoshita, Akitoshi. AU - Kigasawa, Hisato. AU - Osugi, Yuko. AU - Koike, Kazutoshi. AU - Kawa, Keisei. AU - Kato, Koji. AU - Atsuta, Yoshiko. AU - Kudo, Kazuko. PY - 2014/5. Y1 - 2014/5. N2 - Allogeneic hematopoietic stem cell transplantation (HSCT) has not been widely used in patients with acute myeloid leukemia (AML) and Down syndrome (DS) due to fear of transplantation-related toxicity. A retrospective analysis of the outcome of allogeneic HSCT was conducted in 15 patients with AML and DS. The five patients transplanted with the reduced intensity conditioning (4 in complete remission (CR) and 1 in non-CR) had a ...
Ringden, O.; Labopin, M.; Schmid, C.; Sadeghi, B.; Polge, E.; Tischer, J.; Ganser, A.; Michallet, M.; Kanz, L.; Schwerdtfeger, R.; Nagler, A.; Mohty, M. (2016): Sequential chemotherapy followed by reduced intensity conditioning and allogeneic hematopoietic stem cell transplantation in adult patients with relapse or refractory acute myeloid leukemia (AML): a survey from the Acute Leukemia Working Party of EBMT. In: Bone Marrow Transplantation, Vol. 51: S476-S477 ...
TY - JOUR. T1 - Non-myeloablative allogeneic hematopoietic stem cell transplants.. AU - Fagioli, Franca. AU - Ricchiardi, Alberto. AU - Carnevale-Schianca, Fabrizio. PY - 2002/8. Y1 - 2002/8. UR - UR - M3 - Article. C2 - 12412384. AN - SCOPUS:0036673360. VL - 87. SP - 13. EP - 19. JO - Haematologica. JF - Haematologica. SN - 0390-6078. IS - 8 Suppl. ER - ...
After autologous hematopoietic cell transplantation (HCT) in the first complete remission (CR1), patients with acute myeloid leukemia (AML) may relapse and undergo allogeneic HCT in the second complete remission (CR2). The aim of this study was to analyze the outcome of allogeneic HCT performed in CR2 comparing patients with prior consolidation by autologous HCT versus patients with chemotherapy consolidation. Included were 2619 adults with allogeneic HCT in CR2 from 2000 to 2017 with (n = 417) or without (n = 2202) prior autologous HCT. Patient groups were not entirely comparable; patients with prior autologous HCT were younger, had less often a favorable cytogenetic profile, had more commonly donors other than matched siblings, and more often received reduced-intensity conditioning. In multivariate analysis, nonrelapse mortality risks in patients with prior autologous HCT were 1.34 (1.07 to 1.67; P =.01) after adjustment for age, cytogenetic risk, transplant year, donor, conditioning ...
TY - JOUR. T1 - Allogeneic hematopoietic cell transplantation for patients with TP53 mutant or deleted chronic lymphocytic leukemia. T2 - Results of a prospective observational study. AU - Schetelig, Johannes. AU - Hoek, Jennifer. AU - Stilgenbauer, Stephan. AU - Middeke, Jan Moritz. AU - Andersen, Niels Smedegaard. AU - Fox, Christopher P.. AU - Lenhoff, Stig. AU - Volin, Liisa. AU - Shimoni, Avichai. AU - Schroyens, Wilfried. AU - van Gelder, Michel. AU - Bunjes, Donald. AU - van Biezen, Anja. AU - Baldauf, Henning. AU - de Wreede, Liesbeth C.. AU - Tournilhac, Olivier. AU - Kroeger, Nicolaus. AU - Yakoub-Agha, Ibrahim. AU - Dreger, Peter. PY - 2020/8/16. Y1 - 2020/8/16. KW - FOLLOW-UP. KW - RETROSPECTIVE ANALYSIS. KW - EUROPEAN-SOCIETY. KW - CLL. KW - BLOOD. U2 - 10.1038/s41409-020-01013-y. DO - 10.1038/s41409-020-01013-y. M3 - Letter. JO - Bone Marrow Transplantation. JF - Bone Marrow Transplantation. SN - 0268-3369. ER - ...
PubMed journal article: Effect of graft source on unrelated donor hemopoietic stem cell transplantation in adults with acute myeloid leukemia after reduced-intensity or nonmyeloablative conditioning: a study from the Société Francaise de Greffe de Moelle et de Thérapie Cellulaire. Download Prime PubMed App to iPhone, iPad, or Android
PURPOSE: Age has long been used as a major factor for assessing suitability for allogeneic hematopoietic cell transplantation (HCT). The HCT-comorbidity index (HCT-CI) was developed as a measure of health status to predict mortality risk after HCT. Whether age, comorbidities, or both should guide decision making for HCT is unknown. PATIENTS AND METHODS: Data from 3,033 consecutive recipients of HLA-matched grafts from five institutions contributed to this analysis. Patients were randomly divided into a training set to develop weights for age intervals and a validation set to assess the performance of prognostic models. RESULTS: In the training set, patients age 20 to 39 years, 40 to 49 years, 50 to 59 years, and ≥ 60 years had hazard ratios for nonrelapse mortality (NRM) of 1.21 (P = .29), 1.48 (P = .04), 1.75 (P = .004), and 1.84 (P = .005), respectively, compared with those age younger than 20 years. Consequently, age ≥ 40 years was assigned a weight of 1 to be added to the HCT-CI to ...
Clinical trial for Multiple Myeloma , Autologous Stem Cell Transplant (ASCT) With Intravenous Busulfan and Melphalan as Conditioning Regimen
This trial will evaluate the efficacy and the safety of a strategy of allogeneic stem cell transplantation including Rituximab in the conditioning regim
Transforming growth factor β-1, encoded by the TGFB1 gene, is a cytokine that plays a central role in many physiologic and pathogenic processes. We have sequenced TGFB1 regulatory region and assigned allelic genotypes in a large cohort of hematopoietic stem cell transplantation patients and donors. In this study we analyzed 522 unrelated donor-patient pairs and examined the combined effect of all the common polymorphisms in this genomic region. In univariate analysis, we found that patients carrying a specific allele, p001, showed significantly reduced overall survival (5-year overall survival 30.7% for p001/p001 patients vs 41.6% others; p=0.032) and increased non-relapse mortality (1-year non-relapse mortality: 39.0% vs 25.4%; p=0.039) after transplantation. In multivariate analysis, the presence of a p001/p001 genotype in patients was confirmed as an independent factor for reduced overall survival (hazard ratio=1.53 [1.04-2.24]; p=0.031), and increased non-relapse mortality (hazard ...
Results from a randomized, double-blind, placebo-controlled trial show that letermovir protects from viral infection in CMV-seropositive individuals following allogeneic hematopoietic cell transplantation.
BACKGROUND: Allogeneic hematopoietic cell transplantation (HCT) offers curative potential to a number of older patients with acute myeloid leukemia (AML) in their first complete remission. However, there are limited data in the literature concerning post-HCT outcomes for older patients in their second complete remission (CR2). METHODS: The purpose of the current study was to retrospectively investigate within the Center for International Blood and Marrow Transplant Research database parameters influencing posttransplant outcomes for patients 60 years of age or older undergoing HCT for AML in CR2. RESULTS: In total, 196 patients from 78 centers were identified; the median age was 64 years (range, 60-78 years). Seventy-one percent had a Karnofsky performance status ≥ 90 at the time of HCT. Reduced-intensity conditioning regimens were used in 159 patients (81%). A univariate analysis demonstrated a 3-year overall survival (OS) rate of 42% (95% confidence interval [CI], 35%-49%), a leukemia-free ...
Looking for hematopoietic cell transplantation? Find out information about hematopoietic cell transplantation. The artificial removal of part of an organism and its replacement in the body of the same or of a different individual. To remove a plant from one location... Explanation of hematopoietic cell transplantation
Autologous Hematopoietic Stem Cell Transplantation in 48 Patients With End-Stage Chronic Liver Diseases The only presently viable treatment for end-st...
Clinical trial for Aplastic Anemia , Study of Fludarabine + Cyclophosphamide + TBI Conditioning Regimen for Double Units Cord Blood Transplantation(CBT)in Severe Aplastic Anemia(SAA)
Twenty-three leukaemia patients with a median age of 41 years (range 21-64) were enrolled into and treated on this trial from sites in Canada, Belgium, Germany and the United Kingdom. Patients were eligible for an allogeneic hematopoietic stem cell transplantation (HSCT) but could not find a matching donor in time. Sixteen patients had acute myeloid leukaemia (AML) and seven had acute lymphoblastic leukaemia (ALL). Patients were either in first or second complete remission at the time of the HSCT and the majority of patients (57%) had a poor prognosis based on their disease risk index and cytogenetic profile. A myeloablative conditioning regimen was used and (haploidentical) donor grafts were depleted of T-cells (CD34+ selection) prior to transplantation. Patients engrafted rapidly (median 12 days) and ATIR101™ was subsequently infused at a fixed dose of 2×106 CD3+ cells/kg at a median of 28 days post-transplant.. The median follow-up, on March 24, 2016, was 414 days (range 110 - 742) ...
The chemotherapy or irradiation given immediately prior to a transplant is called the conditioning or preparative regimen. The purpose is to help eradicate the patients disease prior to the infusion of HSC and to suppress immune reactions. Chemotherapy drugs and radiation both damage DNA in the cell nucleus which kills rapidly dividing cells by triggering a self-destruct mechanism called apoptosis. Bone marrow cells divide frequently and are particularly sensitive to this treatment. The bone marrow can be ablated at doses that cause minimal injury to other tissues. In allogeneic transplants a combination of cyclophosphamide with busulfan or total body irradiation is commonly employed. This treatment also has an immunosuppressive effect which prevents rejection of the HSC by the recipients immune system. Autologous transplants may also use these conditioning regimens but many other chemotherapy combinations can be used depending on the type of disease. Non-myeloablative allogeneic HSCT is a ...
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The Pretransplantation Assessment of Mortality (PAM) score is a risk score for mortality after allogeneic hematopoietic SCT (HSCT). Ethnicity is a genetically determined factor that correlated with immune-mediated outcomes of allogeneic HSCT. We evaluated the predictive value of the PAM score for transplant outcome in 276 Japanese populations in which transplant-related complications occur less frequently than Caucasians. The PAM score effectively risk-stratified these patients for survival; overall survival (OS) at 2 years was 100%, 80.2%, 49.4%, and 13.9% in the categories 1, 2, 3, and 4, respectively, showing a clear distinction of OS by categories (P|0.001). In addition, the PAM score is useful for the prediction of transplant outcomes both in patients with standard-risk underlying diseases and those with high-risk diseases. The PAM score developed in Caucasian populations is thus useful in non-Caucasian populations.
Abstract. Introduction: Early response rates to non-myeloablative therapy are encouraging, however long term remissions remain elusive. Manipulating donor lymp
New conditioning regimens are still needed to maximize efficacy and limit treatment-related deaths of allogeneic transplantation for advanced hematologi
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The preparative or conditioning regimen is a critical element in the hematopoietic cell transplant procedure. The purpose of the preparative regimen is twofold:To provide adequate immunosuppression to prevent rejection of the transplanted graftTo era
For patients with advanced disease, the challenge is two-fold: Since older patients will be prepared for transplantation with RIC regimens, providing a less cytotoxic component and a lesser debulking effect than is achievable with high-intensity conditioning regimen, it appears advisable (although no controlled data exist) to use debulking therapy before transplantation. Several retrospective analyses have attempted to determine the impact of pre-transplant therapy, particularly with HMAs. It is premature to draw firm conclusions, again, because no controlled studies are available. Clinical wisdom, however, holds that a debulking attempt is indicated in patients with 5% myeloblasts or more who are heading for a RIC transplant regimen. Classically, induction-type chemotherapy has been used which historically has been associated with mortality in the range of 10% or even higher. The advent of HMAs offers an alternative. They are well tolerated, and 40% to 50% of patients derive clinically relevant ...
Hematopoietic Cell Transplantation - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.
While all three types can replenish a patients blood and bone marrow cells, there are advantages and disadvantages to each. The doctor will suggest the best type of stem cell for your childs illness.. The next step in the transplantation process is conditioning therapy, which kills unhealthy cells (like cancer cells) to make room for stem cells to grow and/or weakens the immune system so that theres less chance of the body rejecting the new cells.. One type of conditioning therapy delivers high doses of chemotherapy and/or radiation to kill cells, destroy the bone marrow, and weaken the immune system. Most kids will get this type of therapy. Another type of conditioning therapy delivers lower doses of chemotherapy, radiation, or another treatment to weaken the immune system. The doctor will decide which type of conditioning therapy is best.. Soon after the conditioning phase, the transplant itself will be done through intravenous (IV) infusion, and healthy stem cells will be introduced to the ...
Curr Res Transl Med. 2016 Apr-Jun;64(2):107-13. doi: 10.1016/j.retram.2016.03.004. Epub 2016 Jun 1. Resetting the immune response after autologous hematopoietic stem cell transplantation for autoimmune diseases. Arruda LC1, Clave E2, Moins-Teisserenc H2, Douay C2, Farge D3, Toubert A2. Author information Abstract
Curr Res Transl Med. 2016 Apr-Jun;64(2):107-13. doi: 10.1016/j.retram.2016.03.004. Epub 2016 Jun 1. Resetting the immune response after autologous hematopoietic stem cell transplantation for autoimmune diseases. Arruda LC1, Clave E2, Moins-Teisserenc H2, Douay C2, Farge D3, Toubert A2. Author information Abstract
There are few treatment options for advanced CLL. Standard transplants, which involve powerful doses of pre-transplant chemotherapy to wipe out as much of the leukemia as possible, have proven too toxic for older patients and those with co-existing diseases. Over the past decade, researchers have developed reduced-intensity conditioning (RIC) regimens, using lower chemotherapy doses that are more tolerable but rely entirely on the activity of the transplanted immune cells to battle the leukemia. Usually this is insufficient to keep the cancer at bay long-term and the disease progresses ...
Introduction: Cardiotoxicity is a relatively frequent and potentially serious complication of antitumor treatment. Anthracyclines and other high-dose
Schlenk, R F; Taskesen, E; van Norden, Y; Krauter, J; Ganser, A; Bullinger, L; Gaidzik, V I; Paschka, P; Corbacioglu, A; Göhring, G; Kündgen, A; Held, G; Götze, K; Vellenga, E; Kuball, J; Schanz, U; Passweg, J; Papst, T; Maertens, J; Ossenkoppele, G J; Delwel, R; Döhner, H; Cornelissen, J J; Döhner, K; Löwenberg, B (2013). The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA. Blood, 9(122):1576-1582.. Lugthart, S; Gröschel, S; Beverloo, H B; Kayser, S; Valk, P J; van Zelderen-Bhola, S L; Ossenkoppele, G J; Vellenga, E; van den Berg-de Ruiter, E; Schanz, U; Verhoef, G; Vandenberghe, P; Ferrant, A; Köhne, C H; Pfreundschuh, M; Horst, H A; Schlegelberger, H; Jotterand, M; Krauter, J; Pabst, T; Theobald, M; Schlenk, R F; Delwel, R; Döhner, K; Löwenberg, B; Döhner, H (2010). Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q ...
In chemotherapy as a conditioning regimen in hematopoietic stem cell transplantation, a study of people conditioned with ... "Defining the intensity of conditioning regimens: working definitions". Biology of Blood and Marrow Transplantation. 15 (12): ... Twelve years before the pharmacist was diagnosed with the condition, she had worked for 20 months in a hospital where she was ... Drugs used in chemotherapy can induce cell stress, which can kill a cancer cell; however, under certain conditions, cells ...
"Cardiac transplantation: since the first case report". Grand Rounds. Archived from the original on 2010-10-23. Riley DS, Barber ... "Share and Find Treatment Reviews for Medical Conditions". Treatment Report. Archived from the original on 2016-07-29. " ...
Hourigan, C. "IMPACT OF CONDITIONING INTENSITY OF ALLOGENEIC TRANSPLANTATION FOR ACUTE MYELOID LEUKEMIA WITH GENOMIC EVIDENCE ... Stenger, Matthew (2020-01-17). "The ASCO Post". Conditioning Intensity for Allogeneic Transplantation in Patients With AML. ... Impact of conditioning intensity of allogeneic transplantation for acute myeloid leukemia with genomic evidence of residual ... "Impact of Conditioning Intensity of Allogeneic Transplantation for Acute Myeloid Leukemia With Genomic Evidence of Residual ...
The condition may also occur without any clear reason. The most commonly affected bone is the femur. Other relatively common ... Other risk factors include radiation therapy, chemotherapy, and organ transplantation. Osteonecrosis is also associated with ... Under favorable conditions, the remaining inorganic mineral volume forms a framework for establishment of new, fully functional ... The condition may also occur without any clear reason. Bisphosphonates are associated with osteonecrosis of the mandible. ...
Beta thalassemia major is a severe medical condition. A severe anemia is seen starting at 6 months of age. Without medical ... Beta thalassemia major can be treated by lifelong blood transfusions or bone marrow transplantation. According to a recent ... condition. The homozygous allele has become one of the deadliest genetic factors, whereas people heterozygous for the mutant ...
The status of this condition as a GSD has been disputed. Making a diagnosis for a genetic or rare disease can often be ... Cardiac transplantation has been performed as a treatment; however, most patients die early in life. Danon disease was ... The following resources provide information relating to diagnosis and testing for this condition. If you have questions about ... Orphanet lists international laboratories offering diagnostic testing for this condition. RP-A501 is an AAV-based gene therapy ...
Captive raptors, such as falcons and hawks, are susceptible to this disease if they are kept in poor conditions and especially ... People who are immunocompromised - such as patients undergoing hematopoietic stem cell transplantation, chemotherapy for ... Smith NL, Denning DW (April 2011). "Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma". ... Transplantation. 87 (2): 256-260. doi:10.1097/TP.0b013e31819288d5. PMID 19155981. S2CID 40438193. Martín-Rabadán P, Gijón P, ...
This condition was first described in 2012. Gámez-Díaz L, August D, Stepensky P, Revel-Vilk S, Seidel MG, Noriko M, Morio T, ... These include hematopoietic stem cell transplantation, immunoglobulin replacement and immunosuppressive treatment. ... LPS-responsive beige-like anchor protein deficiency is a rare genetic condition caused by the absence of LPS-responsive beige- ... like anchor protein (LRBA). The presentation of this condition is variable making the diagnosis difficult. The most common ...
It can also involve bone marrow transplantation. Information on prognosis is limited by the rarity of the condition. Prognosis ... 64-70% of people with this condition are male, and most are elderly, with a median age of 65. The first known case of acute ... Di Guglielmo was the first to recognize the leukemic nature of the condition, and it is sometimes referred to as Di Guglielmo's ...
The only definitive treatment for this condition currently is lung transplantation. Median survival without treatment is 3 ... This condition was first described in 1978. This condition has been reported in cats. and dogs. Ortiz-Bautista C, Hernández- ... Pulmonary veno-occlusive disease This condition has been reported in patients with Ehlers Danlos syndrome, CREST syndrome and ...
v t e (Articles with short description, Short description is different from Wikidata, All stub articles, Cutaneous condition ... Cases involving severe pulmonary complication can be considered for lung transplantation. Skin lesion List of cutaneous ... "ANOTHER syndrome-Familial presentations of progressive lung disease leading to double lung transplantation: A case report and ... conditions James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed ...
C. R. Fleming, E. R. Dickson, E. G. Harrison, Jr: Splenosis: auto-transplantation of splenic tissue. Widmann, MAJ Warren D. ( ... Multiple implants of splenic tissue can mimic the appearance of some cancerous conditions. This can be clarified through ... Widmann, MAJ Warren D. (1971-02-01). "Splenosis: A Disease or a Beneficial Condition?". Archives of Surgery. 102 (2): 152-8. ... 1971-02-01). "Splenosis: A Disease or a Beneficial Condition?". Archives of Surgery. 102 (2): 152-8. doi:10.1001/archsurg. ...
The only long-term treatment option for the condition is liver transplantation. While awaiting transplantation, people with HRS ... and all other therapies can best be described as bridges to transplantation. While liver transplantation is by far the best ... The condition is quite common: approximately 10% of individuals admitted to hospital with ascites have HRS. A retrospective ... The diagnosis of hepatorenal syndrome is based on laboratory tests of individuals susceptible to the condition. Two forms of ...
Caimi G, Canino B, Lo Presti R, Urso C, Hopps E (2017). "Clinical conditions responsible for hyperviscosity and skin ulcers ... Experimental and Clinical Transplantation. 13 (3): 290-4. doi:10.6002/ect.2014.0013. PMID 24679054. ... Cryofibrinogenemia refers to a condition classified as a fibrinogen disorder in which a person's blood plasma is allowed to ...
Under natural conditions there are up to 320plants/ha. The seedlings need ample water after planting. A transplantation of the ... Drechsel, Pay; Zech, Wolfgang (1988). "Site conditions and nutrient status of C. edulis (Caesalpiniaceae) in its natural ...
Allogeneic stem cell transplantation can induce durable remissions for heavily pre-treated patients. As of October 2010, there ... Ibrutinib is another agent that has been approved for use in this condition. Combination treatment with Ibrutinib and Rituximab ... Autologous bone marrow transplantation is a treatment option. Zanubrutinib is indicated for the treatment of adults with ... Yang L, Wen B, Li H, Yang M, Jin Y, Yang S, Tao J (1999). "Autologous peripheral blood stem cell transplantation for ...
Hematopoietic stem cell transplantation is the only known cure for ZAP70 deficient SCID. ZAP70 deficiency SCID is estimated to ... Children with this condition typically present with infections and skin rashes. Unlike many forms of SCID, absolute lymphocyte ... Fewer than fifty people with this condition have been identified. Online Mendelian Inheritance in Man (OMIM): 176947 Otsu M, ...
The condition is diagnosed by fluorescent in situ hybridization and treated with thymus transplantation. Severe combined ... Because of defects in this condition, self antigens are not expressed, resulting in T cells that are not conditioned to ... In this condition, the T cells developed in the thymus are directed against the tissues of the body. This is because the ... The condition is virtually indistinguishable from graft versus host disease. Myasthenia gravis is an autoimmune disease most ...
... and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients ... Dose-reduced conditioning before allogeneic stem cell transplantation: principles, clinical protocols and preliminary results ... The FLAMSA protocol is most often used as an induction part of a reduced-intensity conditioning regimen for patients eligible ... March 2012). "Upfront allogeneic blood stem cell transplantation for patients with high-risk myelodysplastic syndrome or ...
Liver transplantation has proven to be effective for ATTR familial amyloidosis due to Val30Met mutation. In 2011 the European ... Fibrinogen, apolipoprotein A1, and lysozyme are associated with a closely related condition, familial visceral amyloidosis. ... July 2006). "Impact of liver transplantation on cardiac autonomic denervation in familial amyloid polyneuropathy". Medicine ( ... Medicines Agency approved tafamidis for this condition. The FDA rejected the application for marketing approval in the US in ...
In more severe cases, a partial or complete corneal transplantation may be considered. However, it is common for the dystrophy ... Reis-Bücklers corneal dystrophy is not associated with any systemic conditions. The dystrophy was described in 1917 by Reis and ...
Histology in this condition often shows increased growth of lymphoid tissue. In patients who have undergone transplantation, ... This response to transplantation often causes prolonged diarrhea if the colon is affected. Typical symptoms also include rash. ... Depending on the severity of the condition, pouch revision surgery may need to be performed. In some cased the pouch may need ... In the United Kingdom 10 per 100,000 people newly develop the condition a year while the number of people affected is 243 per ...
"Rajinikanth's Condition Stable: Hospital". NDTV. Archived from the original on 10 February 2014. Retrieved 1 July 2011. "Modi ... It was widely reported that he required a kidney transplantation, which was later denied by Dhanush. On 21 May 2011, Aishwarya ... The hospital maintained that Rajinikanth was in stable condition and showed positive response to treatment. ... Rajinikanth took the case of campaigning in support of corneal transplantation via television and public speeches. In 2011, ...
Tissue is stored in tissue establishments or tissue banks under cryogenic conditions. Fluids such as blood, blood products and ... urine are stored in fluid banks under similar conditions. The collection, storage, analysis and transplantation of human tissue ... Food and Drug Administration (2003). "Part 1270: 'Human Tissue Intended for Transplantation'". Title 21--Food and Drugs. Code ... Biomedical tissue is biological tissue used for organ transplantation and medical research, particularly cancer research. When ...
In that, both conditions can present with swollen, stiff and deformed joints. Emerging therapies for genetic skeletal ... In some instances as malignant infantile osteopetrosis, hematopoietic stem cell transplantation can be life-saving. " ... Cleidocranial dysostosis is a general skeletal condition named for the collarbone (cleido-) and cranium deformities which ... The features associated with this condition include mild to moderate learning difficulties, short stature, unique facial ...
Lung transplantation replaces a chronic condition with the ongoing need for treatment. There is a post-surgical median survival ... Indeed, this condition frequently accompanies severe heart or lung conditions. A 1973 World Health Organization meeting was the ... Lung transplantation may be an option in severe cases. The frequency of occurrence is estimated at 1,000 new cases per year in ... The condition may make it difficult to exercise. Onset is typically gradual. A patient is deemed to have pulmonary hypertension ...
He objected to organ transplantation viewing it as a form of Cannibalism. In 2004 he criticized the conditions of accepting ... but also due to the changes to conditions of social life its goals will never become exhausted. Quite the opposite, the role of ... their role in the procedure would be limited to recognizing that the patient's condition is irreversible (in doubtful cases, ...
A European Group for Blood and Marrow Transplantation Report". Biology of Blood and Marrow Transplantation. 19 (10): 1522-5. ... List of cutaneous conditions Liebow, Averill A.; Carrington, Charles R.B.; Friedman, Paul J. (1972). "Lymphomatoid ... In recent years hematopoietic stem cell transplantation has been performed on LG-patients with relative good success; a 2013 ... The remaining two patients died from sepsis after the transplantation. The current mortality is over 60% after 5 years. However ...
The condition affects about 1 in 2,500 people of European descent. Severe deficiency occurs in about 1 in 5,000. In Asians it ... A1AD is a leading reason for liver transplantation in newborns. In newborns and children, A1AD may cause jaundice, poor feeding ... Both conditions are the makeup of chronic obstructive pulmonary disease (COPD). Normal blood levels of alpha-1 antitrypsin may ... About 3% of people with COPD are believed to have the condition. Alpha-1 antitrypsin deficiency was first described in the ...
... of transplantation using various hematopoietic cell sources in children with Hurler syndrome after myeloablative conditioning ... In the short term, umbilical cord blood transplantation improved neurodevelopmental function and survival. A follow-up study ... Escolar and colleagues report that early treatment with umbilical cord blood transplantation can improve somatic impairment, ... Escolar's research focuses on describing the natural history of rare neurodegenerative conditions and developing qualitative ...
Rettig, R.A.; Jacobson, P.D.; Farquhar, C.M.; Aubry, W.M. (2007). False Hope: Bone Marrow Transplantation for Breast Cancer: ... "Statistical research on conditions caused by calculi by Doctor Civiale". Int J Epidemiol. 30 (6): 1246-1249. doi:10.1093/ije/ ... Bone Marrow Transplantation for Breast Cancer. Oxford University Press. p. 183. ISBN 978-0-19-974824-2. .. ... trials with allocation concealment and complete follow-up involving a homogeneous patient population and medical condition. In ...
Benign conditions that are not associated with an abnormal proliferation of tissue (such as sebaceous cysts) can also present ... "The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation". N. Engl. J. Med. 332 (1 ... Tumors may be caused by conditions other than an overgrowth of neoplastic cells, however. Cysts (such as sebaceous cysts) are ... metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well.[3] The word is from ...
Under normal conditions, pleural fluid is secreted by the parietal pleural capillaries at a rate of 0.6 millilitre per kilogram ... liver or lung transplantation, insertion of ventricular shunt as a treatment method of hydrocephalus,[7][8] and intra- or ... if a patient identified by Light's criteria as having an exudative pleural effusion appears clinically to have a condition that ...
Vascular stapler for reducing warm ischemia in organ transplantation. With this model each stapler end can be mounted on donor ... in safe conditions when the time required does not influence donor organ preservation, i.e. at the back table in cold ischemia ... An exception to that however could be organ transplantation where these two phases, i.e.device positioning at the vascular ... condition for the donor organ and after native organ removal in the recipient. This is finalized to make as brief as possible ...
Conditions. Organ system failure. Shock sequence. SIRS. Sepsis. Severe sepsis. Septic shock. Multiple organ dysfunction ... Transplantation. Decortication. Heart-lung transplant. Chest wall, pleura,. mediastinum,. and diaphragm. pleura/pleural cavity ... This includes ventilators for use at home for treatment of chronic conditions such as sleep apnea or COPD and in the ICU ... Breaths can also be cycled when an alarm condition such as a high pressure limit has been reached. ...
"The term environment refers not only to air, water, and soil but also to substances and conditions at home and at the workplace ... "Cancer Spread By Transplantation Extremely Rare: In Very Rare Case, Woman Develops Leukemia from Liver Transplant". 2009-07-15 ...
Richter, G (1870). Manual of Coorg- A Gazetteer of the natural features of the country and the social and political condition ... The day signifies the completion of "nati" - meaning the transplantation of the rice (paddy) crop. The festival signifies the ... Richter, G (1870). Manual of Coorg- A Gazetteer of the natural features of the country and the social and political condition ...
Conditions that indicate the presence of neutropenic fever are implanted devices; leukemia induction; the compromise of mucosal ... often require hematopoietic stem cell transplantation as a treatment.[2] ... depending on the individual's condition).[42] Guidelines for neutropenia regarding diet are currently being studied.[43] Those ... as the most common genetic reason for this condition.[7] Acquired neutropenia (immune-associated neutropenia) is due to anti- ...
The common punch size used to diagnose most inflammatory skin conditions is the 3.5 or 4 mm punch.[citation needed][2] ... It is not infrequent for two, three or more biopsies to be performed by different doctors for the same skin condition, before ...
Buehler, M. J.; Yung, Y. C. (2009). "Deformation and failure of protein materials in physiologically extreme conditions and ... both during transplantation and implementation of biocompatible materials.[33] ... is to quantify the acute and chronic toxicity of material and determine any potential adverse effects during use conditions, ... is related to the behavior of biomaterials in various environments under various chemical and physical conditions. The term may ...
... a similar concept which is applied in hematopoietic stem cell transplantation (HSCT), which is a common treatment for patients ... Conditions. *Radiation burn. *Radiation-induced cancer. *Radiation-induced cognitive decline. *Radiation-induced lung injury ...
"Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia". The ... Medical condition. .mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100 ...
These models are generated by methods including retroviral insertion mutagenesis or graft transplantation of cancerous cells. ... The machinery of replication and genome maintenance can be damaged by mutations, or altered by physiological conditions and ...
They are used for research in immunology and transplantation.. *Severe combined immunodeficiency (SCID) mice, with an almost ... conditions usually have a rather immature immune system with a deficit of memory T cells. These mice may have limited diversity ... of the microbiota, which directly affects the immune system and the development of pathological conditions. Moreover, ...
Heimbürger, Olof (1 January 2019). "29 - Peritoneal Physiology". Chronic Kidney Disease, Dialysis, and Transplantation (Fourth ... a condition called ascites. ...
Fecal microbiota transplantation[edit]. Fecal microbiota transplant, also known as a stool transplant, is roughly 85% to 90% ... Wilkins T, Sequoia J (August 2017). "Probiotics for Gastrointestinal Conditions: A Summary of the Evidence". American Family ... When stressed, the bacteria produce spores that are able to tolerate extreme conditions that the active bacteria cannot ... May 2015). "Fecal Microbiota Transplantation for Clostridium difficile Infection: A Systematic Review". Annals of Internal ...
The condition is diagnosed by fluorescent in situ hybridization and treated with thymus transplantation.[15] ... Because of defects in this condition, self antigens are not expressed, resulting in T cells that are not conditioned to ... The condition is virtually indistinguishable from graft versus host disease.[19]. Myasthenia gravisEdit. Myasthenia gravis is ... In this condition, the T cells developed in the thymus are directed against the tissues of the body. This is because the ...
Less common indications include evaluation of lung transplantation, preoperative evaluation, evaluation of right-to-left shunts ...
Benign conditions that are not associated with an abnormal proliferation of tissue (such as sebaceous cysts) can also present ... "The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation". N. Engl. J. Med. 332 (1 ... Tumors may be caused by conditions other than an overgrowth of neoplastic cells, however. Cysts (such as sebaceous cysts) are ... metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well.[3] The word is from ...
The bombings turned out to be much less effective than the recent Gulf War, which had conditioned the public's understanding of ... 2010: The Transplantation Society and the Spanish National Transplant Organization. *2011: Bill Drayton ... The initial mandate of UNPROFOR was to ensure stable conditions for peace talks, and security in three demilitarized "safe- ...
"History of clinical transplantation". Thomas E. Starzl Transplantation Institute, University of Pittsburgh; Starzl TE. Dibukak ... kang diarani preparative regimen utawa conditioning kanggo nyegah panulakan organ donor déning sistem kakebalan inang.[86] ... "History of clinical transplantation". Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center,; ... "The unfinished legacy of liver transplantation: emphasis on immunology". Transplantation Institute, Department of Surgery, ...
"Selected health conditions and risk factors, by age: the United States, selected years" (PDF). Archived (PDF) from the original ... "Nephrology, Dialysis, Transplantation. 23 (1): 47-51. doi:10.1093/ndt/gfm517. PMID 17890752.. ... This general correlation is particularly useful for consensus data regarding obesity or various other conditions because it can ... "Liver Transplantation. 14 (4): 563-570. doi:10.1002/lt.21395. PMID 18383093. S2CID 13072583.. ...
This condition is most commonly observed in the oceans around Antarctica where melting of the undersides of ice shelves at high ... "Supercooling enables long-term transplantation survival following 4 days of liver preservation". Nature Medicine. 20 (7): 790- ... Plants can also survive extreme cold conditions brought forth during the winter months. Many plant species located in northern ... climates can acclimate under these cold conditions by supercooling, thus these plants survive temperatures as low as −40 °C. ...
A therapy that is intended to stop a medical condition from progressing any further. A medication taken at the earliest signs ... Usually refers to ventricular assist devices to keep the existing heart going, not just until heart transplantation can occur, ... A therapy that is intended to prevent a medical condition from occurring (also called prophylaxis). For example, many vaccines ... A therapy that does not treat or improve the underlying condition, but rather increases the patient's comfort, also called ...
Milland J, Sandrin MS (December 2006). "ABO blood group and related antigens, natural antibodies and transplantation". Tissue ... which can vary widely depending on experimental conditions such as pH, solvent, state of tissue etc. Multiple attempts have ... product safety data needed before the initiation of feasibility trials in serious or immediately life-threatening conditions, ...
In this transplantation of English, speakers from England carried the language to Australia, New Zealand, and North America. ... The relationship between historical and social conditions and linguistic developments is viewed as a unilateral implicational ... These determine sociolinguistic conditions of language contact (such as the acquisition of the other party's language), ...
"Bone Marrow Transplantation. 55 (9): 1706-1715. doi:10.1038/s41409-020-0956-8. ISSN 1476-5365. PMID 32474570. S2CID 218987876. ... The most common issue after treatment with CAR T-cells is cytokine release syndrome (CRS), a condition in which the immune ... something that could be utilized in organ transplantation or rheumatic diseases like lupus.[36][37] ...
The condition required a liver transplant for survival and he underwent one in 1985, but the attempt failed and he died. ... and the American Council on Transplantation, of which he served as honorary chairman. He also worked as a spokesman for the ...
T. cruzi can be transmitted independent of the triatomine bug during blood transfusion, following organ transplantation, or ... so these conditions must be treated separately.[6] Antiparasitic treatment is not recommended for people who have already ... People with Chagas disease who undergo heart transplantation have higher survival rates than the average heart transplant ... transplantation of solid organs from an infected donor can transmit T. cruzi to the recipient.[2] This is especially true for ...
The norovirus can survive for long periods outside a human host depending on the surface and temperature conditions: it can ... such as those with common variable immunodeficiency or with a suppressed immune system after organ transplantation. These ...
Medications with Outcomes after Allogeneic Hematopoietic Cell Transplantation with Busulfan/Cyclophosphamide Conditioning. In: ... In: Biology of Blood and Marrow Transplantation, Vol. 25, No. 7, 07.2019, p. 1424-1431.. Research output: Contribution to ... High-dose busulfan (BU) followed by high-dose cyclophosphamide (CY) before allogeneic hematopoietic cell transplantation (HCT) ... N2 - High-dose busulfan (BU) followed by high-dose cyclophosphamide (CY) before allogeneic hematopoietic cell transplantation ( ...
... and Bortezomib versus High-Dose Melphalan as a Conditioning Regimen for Autologous Hematopoietic Stem Cell Transplantation in ... and her condition. Lisa relapsed after about 5 years, but her condition is currently stable. Lisa wants to help other cancer ... and Bortezomib versus High-Dose Melphalan as a Conditioning Regimen for Autologous Hematopoietic Stem Cell Transplantation in ... and Bortezomib versus High-Dose Melphalan as a Conditioning Regimen for Autologous Hematopoietic Stem Cell Transplantation in ...
Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for ... Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for ...
Successful cord blood transplantation with reduced-intensity conditioning for childhood cerebral X-linked adrenoleukodystorophy ... Successful cord blood transplantation with reduced-intensity conditioning for childhood cerebral X-linked adrenoleukodystorophy ...
Dive into the research topics of Choosing a Reduced-Intensity Conditioning Regimen for Allogeneic Stem Cell Transplantation, ... T1 - Choosing a Reduced-Intensity Conditioning Regimen for Allogeneic Stem Cell Transplantation, Fludarabine/Busulfan versus ... Choosing a Reduced-Intensity Conditioning Regimen for Allogeneic Stem Cell Transplantation, Fludarabine/Busulfan versus ... Choosing a Reduced-Intensity Conditioning Regimen for Allogeneic Stem Cell Transplantation, Fludarabine/Busulfan versus ...
... total-body irradiation and cyclophosphamide as conditioning regimen in allogeneic and autologous bone marrow transplantation ... We conclude that the conditioning regimen with high-dose vincristine combined with cyclophosphamide and F-TBI is feasible and ... We conclude that the conditioning regimen with high-dose vincristine combined with cyclophosphamide and F-TBI is feasible and ... We conclude that the conditioning regimen with high-dose vincristine combined with cyclophosphamide and F-TBI is feasible and ...
Alemtuzumab pre-conditioning with tacrolimus monotherapy in pediatric renal transplantation. Authors. *R Shapiro ... conditioning with alemtuzumab and tacrolimus monotherapy may be a safe and effective regimen in pediatric renal transplantation ... We employed antibody pre-conditioning with alemtuzumab and posttransplant immunosuppression with low-dose tacrolimus ... 2.2 months after transplantation. The incidence of CMV, PTLD and BK virus was 0%; the incidence of posttransplant diabetes was ...
According to the registry of the International Society for Heart and Lung Transplantation, approximately 350-500 pediatric ... heart transplantation procedures are performed worldwide each year, representing about 12% of the total number of heart ... Heart transplantation in infants and children is now accepted therapy. ... The pathophysiology of conditions that necessitate heart transplantation is obviously as varied as the conditions themselves. ...
... after allogeneic hematopoietic stem cell transplantation (HSCT) results in high morbidity and mortality. Effective immunization ... cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation ... By using this website, you agree to our Terms and Conditions, California Privacy Statement, Privacy statement and Cookies ...
... solid organ transplantation; multiple myeloma: ... Underlying conditions below: When both PCV and PPSV23 are ... Immunocompromising conditions, including HIV infection: 3-dose series, even for those who initiate vaccination at age 9 through ... Vaccination is recommended, and additional doses may be necessary based on medical condition or vaccine. See Notes.. Precaution ... Note: PCV13 and PCV15 can be used interchangeably for children who are healthy or have underlying conditions. PCV15 is not ...
Dive into the research topics of Reduced-intensity conditioning for allogeneic stem cell transplantation. Together they form ...
The image below illustrates an algorithm for typically preferred hematopoietic stem cell transplantation cel... ... Hematopoietic stem cell transplantation (HSCT) involves the intravenous (IV) infusion of autologous or allogeneic stem cells to ... optimizing transplantation conditioning, reducing the morbidity and mortality from transplantation conditioning, and preventing ... The preparative or conditioning regimen is a critical element in hematopoietic stem cell transplantation (HSCT). The purpose of ...
Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning for Adult T Cell Leukemia/Lymphoma: ... T1 - Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning for Adult T Cell Leukemia/Lymphoma ... Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning for Adult T Cell Leukemia/Lymphoma: ... Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning for Adult T Cell Leukemia/Lymphoma: ...
Context: A minimally toxic nonmyeloablative regimen was developed for allogeneic hematopoietic cell transplantation (HCT) to ... Dive into the research topics of Long-term outcomes among older patients following nonmyeloablative conditioning and ... N2 - Context: A minimally toxic nonmyeloablative regimen was developed for allogeneic hematopoietic cell transplantation (HCT) ... AB - Context: A minimally toxic nonmyeloablative regimen was developed for allogeneic hematopoietic cell transplantation (HCT) ...
... in an altitudinal transplantation experiment.. Biogeosciences, 18, 2021, 2075-2090.. ... Subalpine grassland productivity increased with warmer and drier conditions, but not with higher N deposition, ... compared to CSreference with no temperature change and with climate conditions comparable to the sites of origin. To uncouple ...
Conditions We See Tab 2 Content. * High Risk Leukaemia (acute and certain chronic types) such as: ... Paediatric Blood and Marrow Transplantation (BMT) Programme. Page Content. ​The Paediatric BMT Programme in NUH and NUS was ...
"Caring for patients with advanced heart conditions requires a team approach. I prioritize communication with other members of ... Miguel A Pinilla Vera, MD, Heart Failure And Transplantation Cardiology , MedStar Health ... and heart transplantation, when medication treatment is no longer an option. He works closely with the cardiac surgeons at ... the mechanisms of the development of heart failure as well as finding better ways to treat patients with this condition. He ...
Allogeneic Blood or Marrow Transplantation with Nonmyeloablative Conditioning and High-Dos Allogeneic Blood or Marrow ... Allogeneic blood or marrow transplantation (alloBMT) is widely used in patients with relapsed/refractory systemic NHL. We ... Transplantation with Nonmyeloablative Conditioning and High-Dose Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis ... For graft-versus-host disease prophylaxis, all patients received post-transplantation cyclophosphamide, mycophenolate mofetil, ...
Browse the archive of articles on Bone Marrow Transplantation ... as conditioning for allogeneic bone marrow transplantation *M ... Conditioning with cyclophosphamide/antithymocyte globulin for allogeneic bone marrow transplantation from HLA-matched siblings ... Bone Marrow Transplantation (Bone Marrow Transplant) ISSN 1476-5365 (online) ISSN 0268-3369 (print) ... Malaria infection after allogeneic bone marrow transplantation in a child with thalassemia *V-B Tran ...
... a Johns Hopkins transplantation expert, answers frequently asked questions about live organ donation. ... Your doctors will evaluate your medical condition and the condition of your organs to determine if you are qualified to be a ... Can I donate my organs if I have a medical condition?. Possibly. Most people can donate, but there are a few exclusions, such ... Just like with any other major surgery, there are risks and a period of critical recovery time for transplantation surgery. For ...
Haplo-identical Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using Peripheral Blood Stem Cells and Post- ... Condition. Aplastic Anemia, Aplastic Anemia, Anemia; Non-Small-Cell Lung Cancer, Myelodysplastic Syndromes (MDS), Severe ... Haploidentical peripheral blood stem cell transplantation (haplo-SCT) has the advantage over cord transplantation of immediate ... Combined haplo-cord transplantation has recently been shown to be a viable transplant option for those patients lacking an HLA ...
Conditioning treatment prior to stem cell transplantation. Conditioning or preparative treatment takes place before ... Conditioning or preparative treatment takes place before transplantation of haematopoietic progenitor cells - the cells that ...
Immune Response in the Liver under Conditions of Infection, Malignancy, and Transplantation. View this Special Issue ...
... male and female pattern baldness are conditions that are, with few exceptions, treated electively. ... encoded search term (Hair Transplantation) and Hair Transplantation What to Read Next on Medscape ... Hair Transplantation Workup. Updated: Jul 28, 2022 * Author: Jeffrey S Epstein, MD, FACS; Chief Editor: Arlen D Meyers, MD, MBA ... Hair Transplantation Techniques for the Transgender Patient. Facial Plast Surg Clin North Am. 2019 May. 27 (2):227-232. [QxMD ...
Related Conditions & Procedures. * Transfusion-Transmitted Diseases * Prion-Related Diseases * Pediatric Kidney Transplantation ...
Condition or disease Intervention/treatment Phase MDS AML Drug: CPX-351 Drug: Daunorubicin Drug: Cytarabine Drug: Azacitidine ... Comparison of Therapies Before Stem Cell Transplantation in Patients With Higher Risk MDS and Oligoblastic AML (PALOMA). The ... Allogeneic stem cell transplantation (alloHCT) is considered the only potentially curative treatment option for MDS patients ... Any serious medical condition, laboratory abnormality or psychiatric illness that would prevent obtaining informed consent. ...
... is a condition that affects the lungs, the kidneys , and the lymphatic system . Explore symptoms, inheritance, genetics of this ... the condition may recur even after lung transplantation. ... This condition may be underdiagnosed because its symptoms are ... Lymphangioleiomyomatosis (LAM) is a condition that affects the lungs, the kidneys. , and the lymphatic system. . The lymphatic ... without lung transplantation, may eventually lead to limitations in activities of daily living, the need for oxygen therapy, ...
Conditioning treatment prior to hematopoietic progenitor cell transplantation. *. Sponsor. *Adienne S.A.; Via Zurigo, 46 6900 ... The dosage is based on your medical condition, body size, and response to treatment. SIDE EFFECTS: See also Warning section. ... MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, ...
  • Busulfan, Melphalan, and Bortezomib versus High-Dose Melphalan as a Conditioning Regimen for Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma. (
  • Fludarabine with busulfan (FB) or melphalan (FM) are 2 more commonly used reduced-intensity conditioning (RIC) regimens for allogeneic stem cell transplantation (HCT).We present a systematic review and meta-analysis of studies comparing these 2 RIC regimens. (
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (
  • Allogeneic hematopoietic stem cell transplantation (HSCT) is an effective treatment for adult T cell leukemia/lymphoma (ATLL), but shows high mortality. (
  • Although allogeneic stem cell transplantation (allo-SCT) offers the opportunity of cure, HLA-matched donors are available for only half the patients needing a transplant. (
  • Haploidentical peripheral blood stem cell transplantation (haplo-SCT) has the advantage over cord transplantation of immediate allograft availability, higher stem cell doses, and the feasibility of repeating cell collections if necessary for collecting CD34+ cells for stem cells boosts or lymphocytes to treat or prevent disease relapse or infection. (
  • Allogeneic stem cell transplantation (alloHCT) is considered the only potentially curative treatment option for MDS patients and is therefore often considered the standard treatment for mainly higher-risk MDS patients up to the age of 75 years. (
  • For some patients who are in remission and can tolerate intensive chemotherapy, the doctor may recommend stem cell transplantation during the consolidation phase of chemotherapy. (
  • Research to determine which patients are most likely to benefit from stem cell transplantation after their first complete remission is evolving. (
  • Studies show that allogeneic stem cell transplantation may benefit patients with high-risk and intermediate-risk AML up to age 75 years and who have an HLA-matched donor. (
  • This is the most common type of stem cell transplantation used to treat AML. (
  • Allogeneic stem cell transplantation, compared to other treatment approaches, is associated with a higher rate of side effects and mortality in patients. (
  • A serious risk of allogeneic and reduced-intensity allogenic stem cell transplantation is graft versus host disease (GVHD) , which develops if the donor's immune cells attack your normal tissue. (
  • The results of haploidentical stem cell transplantation (haploHCT) for patients with acute lymphoblastic leukemia (ALL) transplanted in active disease remain largely unknown. (
  • Hematopoietic stem cell transplantation (HSCT) remains the only curative treatment in patients with higher risk myelodysplastic syndrome (MDS), but the choice of the optimal alternative stem cell source is still a subject of debate in patients lacking an HLA-matched sibling donor. (
  • It has been proposed that bone marrow or hematopoietic stem-cell transplantation, and resulting (mixed) hematopoietic chimerism, lead to immunological tolerance to organs of the same donor. (
  • Poor outcome with hematopoietic stem cell transplantation for bone marrow failure and MDS with severe MIRAGE syndrome phenotype. (
  • Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (
  • To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation. (
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (
  • 2006). Heath-related quality of life in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation. (
  • We analysed the data of 225 consecutive patients who underwent autologous stem cell transplantation (ASCT) at our centre. (
  • 2019. High-dose bendamustine and melphalan conditioning for autologous stem cell transplantation for patients with multiple myeloma. . (
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (
  • In general, the first decision made in the management of patients with myeloma who require systemic therapy is whether stem cell transplantation is part of the strategy. (
  • Effect of donor KIR2DL1 allelic polymorphism on the outcome of pediatric allogeneic hematopoietic stem-cell transplantation. (
  • The diversity of KIR gene in Chinese Northern Han population and the impact of donor KIR and patient HLA genotypes on outcome following HLA-identical sibling allogeneic hematopoietic stem cell transplantation for hematological malignancy in Chinese people. (
  • Distribution of immunoglobulin like receptor gene in Han population in China and the impact thereof on the HLA-identical sibling hematopoietic stem cell transplantation]. (
  • He underwent an HLA-identical sibling peripheral blood stem cell transplantation with fludarabine and melphalan as conditioning chemotherapies before the procedure. (
  • The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. (
  • Cord blood is used the same way that hematopoietic stem cell transplantation is used to reconstitute bone marrow following radiation treatment for various blood cancers, and for various forms of anemia. (
  • 1] Adverse effects are similar to hematopoietic stem cell transplantation, namely graft-versus-host disease and the risk of severe infection while the immune system is reconstituted. (
  • The only cure is a well-matched stem cell transplantation, but this procedure is not widely available to everyone. (
  • In stem cell transplantation, doctors replace a patient's bone marrow with stem cells from a healthy, fully-matched donor (usually a sibling). (
  • High-dose busulfan (BU) followed by high-dose cyclophosphamide (CY) before allogeneic hematopoietic cell transplantation (HCT) has long been used as treatment for hematologic malignancies. (
  • Context: A minimally toxic nonmyeloablative regimen was developed for allogeneic hematopoietic cell transplantation (HCT) to treat patients with advanced hematologic malignancies who are older or have comorbid conditions. (
  • The introduction of reduced-intensity conditioning (RIC) regimens made it possible to offer allogeneic hematopoietic cell transplantation (alloHCT) to older patients with myelodysplastic syndromes (MDS). (
  • Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation. (
  • KIR and HLA genotypes predictive of low-affinity interactions are associated with lower relapse in autologous hematopoietic cell transplantation for acute myeloid leukemia. (
  • We investigated the feasibility and efficacy of high-dose vincristine (4 mg/m 2 over 4 d) combined with fractionated total body irradiation (F-TBI) (200 cGyx2 over 3 d) and cyclophosphamide (60 mg/kg for 2 d) as a preparative regimen in allogeneic (AlloBMT) and autologous (ABMT) bone marrow transplantation for 75 consecutive children (median age at transplant 8.5 years) with acute lymphoblastic leukaemia in second complete remission (CR). (
  • [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (
  • Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (
  • Autologous transplantation is sometimes used for patients who do not have an HLA-matched donor. (
  • OBJECTIVES: I. Evaluate the ability of c-myb antisense oligodeoxynucleotide to purge bone marrow cells of clonogenic chronic myelogenous leukemia tumor cells and repopulate the bone marrow with normal stem cells in patients treated with high-dose busulfan and cyclophosphamide followed by autologous bone marrow transplantation using marrow treated with c-myb antisense oligodeoxynucleotide. (
  • We have also found in a number of different studies that the nucleated cell dose significantly affects transplant-related mortality, 1 , 3-5 survival, 1 , 3 and the speed as well as completeness of hematologic reconstitution after autologous 1 , 6 and allogeneic 3-5 transplantation for hematologic malignancies. (
  • PMR has presented a comprehensive report based on Bone Marrow Transplantation market as per End User (Hospitals, Multispecialty Clinics, and Ambulatory Surgical Centers), Disease Indication (Leukemia, Lymphoma, Myeloma, and Others), Transplant Type (Autologous Bone Marrow Transplant, and Allogeneic Bone Marrow Transplant) based on seven regions. (
  • Biology of Blood and Marrow Transplantation , 25 (7), 1424-1431. (
  • Biology of Blood and Marrow Transplantation , 25 (4), 728-733. (
  • Biology of Blood and Marrow Transplantation , 14 (6), 702-708. (
  • Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2015 Sep 21 (9): 1589-96. (
  • HLHS has diminished as an indication for heart transplantation because of the limited donor supply and the improvements that have been achieved in surgical palliation (ie, the Norwood procedure, with or without the Sano modification). (
  • Design, Setting, and Participants: From 1998 to 2008, 372 patients aged 60 to 75 years were enrolled in prospective clinical HCT trials at 18 collaborating institutions using conditioning with low-dose total body irradiation alone or combined with fludarabine, 90 mg/m2, before related (n=184) or unrelated (n=188) donor transplants. (
  • European results of matched unrelated donor bone marrow transplantation for chronic myeloid leukemia. (
  • Your doctors will evaluate your medical condition and the condition of your organs to determine if you are qualified to be a living organ donor. (
  • Combined haplo-cord transplantation has recently been shown to be a viable transplant option for those patients lacking an HLA matched donor. (
  • Extensive Donor Site Keloids in Follicular Unit Extraction Hair Transplantation. (
  • By this strategy the time interval for donor search can be significantly prolonged leading to a higher proportion of success.Nevertheless, not every patient initially eligible for transplantation undergoes this procedure subsequently. (
  • Allogeneic transplantation uses healthy blood-forming cells from an HLA-matched family member, an unrelated donor, or from umbilical cord blood. (
  • We retrospectively analyzed adult patients with R/R ALL who underwent haploHCT or matched sibling donor (MSD-HCT) as a first transplantation between 2012 and 2020. (
  • In experimental settings, this attractive approach allows development of genuine immunological tolerance to donor tissues using clinically relevant conditioning regimens. (
  • Robin then received the conditioning regimen, followed by donor cell infusion in late July. (
  • A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (
  • Very few medical conditions disqualify one from being an organ or tissue donor. (
  • The infant underwent a 9/10 HLA-A mismatched unrelated donor bone marrow transplant at 3 months of age, with conditioning consisting of 4 days of busulfan given every 6 hours with area under the curve dosing targeted to 800 to 1200 μmol*min/L. cyclophosphamide 50 mg/kg daily for 4 days, and equine antithymocyte globulin 30 mg/kg daily for 3 days. (
  • To report a single-center 10-year experience of outcomes of kidney transplantation in African Americans (AAs) vs Caucasian Americans (CA) and to propose ways in which to improve kidney transplant outcomes in AAs, increased access to kidney transplantation, prevention of kidney disease, and acceptance of organ donor registration rates in AAs. (
  • We compared outcomes of deceased donor (DD) and living donor (LD) renal transplantation in AAs vs CAs in 772 recipients of first allografts at our transplant center from January 1995 to March 2004. (
  • Fatty infiltration of the liver is common in the brain-dead donor population and has a strong correlation with primary nonfunction after cold preservation, a condition that is catastrophic to liver transplant recipients. (
  • Chimerism stability correlated with a significant donor BM-dependent loss of host-derived Vbeta11(+) T cells 3 mo after BM transplantation (Tx). (
  • We evaluated the feasibility of reduced-intensity transplantation using fludarabine and busulfan, with particular focus on the clinical impact of antithymocyte globulin (ATG) in the conditioning regimen. (
  • The conditioning therapy used for a reduced-intensity transplant is of lower intensity than that for a standard stem cell transplant. (
  • Here, we report on a large series of patients with MDS (N = 631) transplanted either with mobilized peripheral stem cells (PBs) from unrelated donors (n = 502) or with umbilical cord blood transplant (UCB, n = 129) as alternative grafts after reduced-intensity conditioning. (
  • The sister’s first hematopoietic stem cell transplant from cord blood with reduced intensity conditioning failed, but she later had a successful matched related transplant with conditioning consisting of busulfan and cyclophosphamide. (
  • Follow patients closely for evidence of transplant-related complications, including hyperacute graft-versus-host disease (GVHD), acute GVHD, chronic GVHD, hepatic veno-occlusive disease (VOD) after reduced intensity conditioning, and steroid-requiring febrile syndrome (without an identified infectious cause), and intervene promptly. (
  • This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (
  • Allogeneic Blood or Marrow Transplantation with Nonmyeloablative Conditioning and High-Dose Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis for Secondary Central Nervous System Lymphoma. (
  • Allogeneic blood or marrow transplantation (alloBMT) is widely used in patients with relapsed/refractory systemic NHL. (
  • Michael Pulsipher of the Saban Research Institute at The Children's Hospital Los Angeles describes how he is working to improve the outcomes for treatments using blood or bone marrow transplantation, particularly in pediatric patients. (
  • We discuss here recent advances obtained by combining regulatory T cell infusion with bone-marrow transplantation. (
  • Dr. Jay Sarthy is a hematologist-oncologist who specializes in pediatric bone marrow transplantation for children with blood cancers and rare genetic conditions, such as telomere syndromes. (
  • Transplantation conditioning is very common before bone marrow transplantation. (
  • Although variables relating to disease biology and patient characteristics are strong determinants of outcome after bone marrow transplantation (BMT), the identification of these nonmodifiable factors is often of limited practical use. (
  • The current scenario is such that there is an increase in the adoption of Bone Marrow Transplantation procedures for treating various chronic diseases. (
  • This scenario is, by all means, favoring the Bone Marrow Transplantation market growth. (
  • Furthermore, favorable reimbursement policies are also expected to contribute to the growth of the European Bone Marrow Transplantation Market. (
  • Bone Marrow Transplantation, 38 , 101-109. (
  • Combinations of anti-LFA-1, everolimus, anti-CD40 ligand, and allogeneic bone marrow induce central transplantation tolerance through hemopoietic chimerism, including protection from chronic heart allograft rejection. (
  • Central transplantation tolerance through hemopoietic chimerism initially requires inhibition of allogeneic stem cell or bone marrow (BM) rejection, as previously achieved in murine models by combinations of T cell costimulation blockade. (
  • This is why cord blood can be used for transplantation as an alternative to bone marrow. (
  • Untreated CKD can result in end-stage renal disease and necessitate dialysis or kidney transplantation. (
  • Over the past two decades, Pakistan has emerged as one of the largest centres for commercial renal transplantation. (
  • Ziaja J, Bozek-Pajak D, Kowalik A, Krol R, Cierpka L. Impact of pancreas transplantation on the quality of life of diabetic renal transplant recipients. (
  • In this study, we investigated posttransplantational survival analysis of patients who underwent renal transplantation in Kyrgyzstan and other Eurasian, predominantly neighboring countries. (
  • Besides the general analysis of survival after renal transplantation, analysis by transplantation years and differences among countries was also included in our study. (
  • At present, few data exist on the use of haploidentical transplantation using post-transplant cyclophosphamide for patients with aplastic anemia that have ATG-refractory disease and are heavily-transfused and HLA-alloimmunized. (
  • This type of transplantation may be a treatment option for older patients who cannot tolerate the high doses of chemotherapy used in preparation for a standard allogeneic stem cell transplant. (
  • Many people with diabetes who have taken daily insulin injections for years have achieved total insulin independence after pancreas transplantation - often for years after the transplant. (
  • It is possible that you will need to receive treatment for another medical condition before you may be considered a good candidate for a lung transplant. (
  • Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. (
  • 1 On the other hand, treatment- and transplant-related factors, which are modifiable, can potentially be manipulated in clinical practice to improve the results of transplantation. (
  • Pancreas After Islet Transplantation: A First Report of the International Pancreas Transplant Registry. (
  • The objective of the present cross-sectional cohort study was to evaluate cross through clinical, biochemical and radiographic oral conditions in a Brazilian population with CKD that was preparing for a kidney transplant, investigating the influence of dialysis duration and status on bone metabolism the prevalence and severity of the changes found. (
  • Clearly, losing hair is not the target, and given the considerable investment made in a high-quality hair transplant, patients caught off guard may be understandably upset about Toronto hair transplantation. (
  • A hair transplant patient recovers very rapidly with minimal incisions under ideal conditions after FUE. (
  • This strip of skin can be divided into as many as 2,000 tiny grafts depending on the patient's condition and the location of the hair transplant. (
  • To get the hair transplant in Visakhapatnam, you need to understand the causes of this condition. (
  • Issues Regarding COVID-19 in Kidney Transplantation The emergence of the COVID-19 Omicron variant has raised questions regarding the management of kidney transplant recipients. (
  • to elucidate the relationship between palliative care and heart transplantation in the view of the transplant team, and to develop a mind map that helps to rethink the palliative approach to the person after heart transplantation. (
  • The Transplant Society and the International Society of Nephrology state, that despite the Istanbul Declaration, which was approved by more than 110 professional and governmental organizations in 2008 for the prevention of crime in transplantation and the prevention of illegal programs, is still not known to what extent the situation is controlled (9). (
  • According to the registry of the International Society for Heart and Lung Transplantation, approximately 600-700 pediatric heart transplantation procedures are performed worldwide each year, representing about 12% of the total number of heart transplants performed. (
  • The lung problems may be progressive and, without lung transplantation, may eventually lead to limitations in activities of daily living, the need for oxygen therapy, and respiratory failure. (
  • As a result, the condition may recur even after lung transplantation. (
  • Lung transplantation is a recognised treatment for patients with end stage pulmonary disease. (
  • To compare the event-free survival at 2 years of CPX-351 vs. conventional care regimens before allogeneic blood cell transplantation as first line treatment in patients with higher risk MDS and oligoblastic AML. (
  • There is a theoretical concern that transmission could occur through organ or tissue transplantation, and although Zika virus RNA has been detected in breast milk, transmission through breastfeeding has not been documented ( 5 ). (
  • We conclude that the conditioning regimen with high-dose vincristine combined with cyclophosphamide and F-TBI is feasible and promising, although its therapeutic advantage should be tested in larger series of patients enrolled in randomized studies. (
  • We reviewed outcomes in 20 consecutive patients with secondary CNS lymphoma who underwent alloBMT with nonmyeloablative conditioning using fludarabine, cyclophosphamide , and 200 cGy total body irradiation . (
  • For graft-versus-host disease prophylaxis, all patients received post- transplantation cyclophosphamide , mycophenolate mofetil , and a calcineurin inhibitor . (
  • 150/90 mmHg), significant cardiovascular impairment or event within previous 12 months or patients who had active autoimmune disease or a medical condition that required immunosuppression. (
  • [ 3 ] Survival of the allograft and the patient is made possible by immunosuppression following transplantation. (
  • An updated list of high-risk underlying conditions, based on what has been reported in the literature as of January 1, 2022 is provided below. (
  • Director of Viral Hepatitis Research in Liver Transplantation, UCSF. (
  • Dr Zein's research focuses on improving disease and treatment outcome in patients with the Hepatitis C virus before and after liver transplantation. (
  • Liver transplantation has become accepted therapy for several causes of irreversible liver disease. (
  • Until recently, the leading indication for liver transplantation in the United States was HCV, which accounted for approximately 30% of new waitlist registrations. (
  • Biliary atresia remains a common indication for liver transplantation in pediatric patients. (
  • Tacrolimus appears to be superior to cyclosporine in liver transplantation and is used in many centers. (
  • Application and success of orthotopic liver transplantation (OLT) has continued to grow, and liver transplantation has become accepted therapy for several causes of irreversible liver disease. (
  • BACKGROUND AND AIMS: Biliary complications (BC) are one of the most common complications following orthotopic liver transplantation (OLT). (
  • We developed novel murine models of liver pre-transplantation stages, where we can study the role of PC in BECs, using conditional ablation of PC (K19CreERT Kif3aflox/flox mouse model). (
  • Our results indicate that PC represent a potential novel therapeutic target to improve biliary regeneration and prevent BC development during liver transplantation. (
  • Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 8, 415-423 (2002). (
  • Liver transplantation may help to recover from HCV. (
  • In order to get relief from liver cancer, liver transplantation is considered. (
  • But, after the liver transplantation, there is a chance to re-infect with the virus. (
  • It is the most common reason for liver transplantation in the United States. (
  • [ 6 ] Over those 16 years, adult heart transplantation became routine and the lower age limit of recipients declined. (
  • Inhibition of acute allograft rejection critically depended on chimerism stability, even if maintained at very low levels around 1%, as was the case for some recipients without busulfan conditioning. (
  • Hair Transplantation Techniques for the Transgender Patient. (
  • Klingbeil KD, Fertig R. Eyebrow and Eyelash Hair Transplantation: A Systematic Review. (
  • Bared A. Beard Hair Transplantation. (
  • Hair transplantation update. (
  • Hair transplantation for the treatment of lichen planopilaris and frontal fibrosing alopecia: A report of two cases. (
  • Surgical complications in hair transplantation: a series of 533 procedures. (
  • Vasudevan B, Neema S, Ghosh K, Singh S, Khera A. Hair transplantation by follicular unit extraction for male androgenetic alopecia: A retrospective observational study from two centers. (
  • Lichen planopilaris following hair transplantation and face-lift surgery. (
  • Hair transplantation can be done from the age of 20 years. (
  • Hair transplantation is the first and best solution for it. (
  • Heart transplantation in infants and children is now accepted therapy. (
  • In infants, congenital malformations are still the most common indication for heart transplantation. (
  • The most common indication for heart transplantation in older children is cardiomyopathy. (
  • One of the most common indications for infant heart transplantation had been hypoplastic left heart syndrome (HLHS) , which occurs in about one in 6000 live births. (
  • Over the past 3 decades, heart transplantation has evolved from a primary indication for treatment of neonates with unrepaired HLHS to the treatment of end-stage heart failure in adolescents and young adults with palliated congenital heart disease. (
  • Survival in excess of 20 years after pediatric heart transplantation has been achieved. (
  • However, although an additional 5 years of life is important for all, the goal of pediatric heart transplantation is to provide as much of a normal life span for these children as possible. (
  • Human orthotopic heart transplantation began on December 3, 1967 when Drs. Chistiaan and Marius Barnard transplanted the heart of a 15-year-old trauma victim into a 55-year-old recipient in Capetown, South Africa. (
  • [ 4 ] Three days later, on December 6, 1967, Dr. Adrian Kantrowitz performed the first orthotopic heart transplantation in a neonate in New York. (
  • For the next 10 years, orthotopic heart transplantation became an option for primary therapy in neonates with hypoplastic left heart syndrome. (
  • and evaluating the necessity of using mechanical pumps, like left ventricular assist devices (LVADs) and heart transplantation, when medication treatment is no longer an option. (
  • Despite these aggressive supportive measures, his condition deteriorated, and he was transferred to a tertiary care facility for possible heart transplantation. (
  • the narratives revealed difficulty in establishing criteria to indicate a person after heart transplantation for palliative care. (
  • The mind map shows conditions that can be considered for the indication of palliative care for people after heart transplantation. (
  • the palliative approach in the context of heart transplantation, in the view of professionals, is permeated by negative feelings and lack of information on the part of the teams. (
  • The proposed mind map brought elements that can guide professionals for the insertion of the person after heart transplantation in the palliative approach. (
  • In the last few decades, doctors have been able to treat Type 1 diabetes with pancreas transplantation. (
  • Diabetes is the most common cause of kidney and pancreas transplantation. (
  • An evidence-based analysis of simultaneous pancreas-kidney and pancreas transplantation alone. (
  • Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity. (
  • Alternative strategies are intensive 7+3 chemotherapy with anthracycline and cytarabine or direct and immediate transplantation. (
  • The immunosuppressive regimens currently used in transplantation to prevent allograft destruction by the host's immune system have deleterious side effects and fail to control chronic rejection processes. (
  • Moreover, the cytotoxic conditioning regimens used to achieve long-term persistence of chimerism are associated with severe side effects that appear incompatible with a routine use in the clinic. (
  • Design - This protocol describes a pragmatic 2-arm, parallel-group, open-label, registry-based, cluster-randomized clinical trial-the Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD) trial. (
  • Patients are subject to a lifelong dependence on insulin and are at a higher risk for heart disease, blindness, kidney failure, and other chronic conditions, in addition to shortened average life expectancy. (
  • Kidney transplantation. (
  • Chronic kidney disease (CKD) is a serious condition associated with premature mortality, decreased quality of life, and increased health-care expenditures. (
  • Transplantation is often used to treat end-stage kidney disease. (
  • To evaluate the oral conditions of patients with chronic kidney disease undergoing dialysis and to determine the influence of dialysis duration and bone metabolism on the prevalence and severity of the alterations found. (
  • The graft transplantation has been used in kidney failure as reliable and effective treatment option since 1936 (1). (
  • The approximate cost of kidney transplantation is $18,000 in India, $32,000 in Nigeria (the most active center), $78,000 in the UK and $117,000 in the US (6). (
  • ABSTRACT Organ transplantation must be viewed in relation to the prevailing cultural, religious and socio-economic conditions of a nation. (
  • If the transplantation was achieved by several countries in 1960s, now it is performed by vast majority of centers. (
  • Shortly, countries and transplantation centers demonstrates variation of survival estimations and risk ratios (2, 7, 8). (
  • To develop an international consensus regarding the appropriate conditions for undertaking clinical trials in xenocorneal transplantation, here we review specific ethical, logistical, scientific, and regulatory issues regarding xenocorneal transplantation, and propose guidelines for conduct of clinical xenocorneal transplantation trials. (
  • Dr. Shapiro and the ITN research team have improved our understanding of the potential of islet transplantation for certain patients with Type 1 diabetes," says NIAID Director Anthony S. Fauci, M.D. "Ongoing studies will further define the clinical utility of this approach. (
  • Clinical efficacy and microbiome changes following fecal microbiota transplantation in children with recurrent clostridium difficile infection. (
  • Ramon Grimalt (Spain) described several disorders related to artificial hair loss in children, including for example trichotillomania, trichoteiromania (hair loss due to hair rubbing) and trichotemnomania (cutting or shaving of the hair), and the clinical differences between these conditions. (
  • Dimitrios Ioannides (Greece) gave an educational talk that reviewed this condition, describing the common clinical features, possible differential diagnoses and treatment options. (
  • Pancreatic islet transplantation as a treatment for type 1 diabetes received a major impetus with the development of the Edmonton protocol and recent clinical trials demonstrating long-term insulin independence out beyond 5 years after transplantation ( 1 - 4 ), although encouraging this therapy will always be limited by the relatively small number of organ donors available for islet isolation. (
  • clinical conditions of the patient, the existence of a tumors are considered rare (KLUSMANN et al. (
  • This literature review examines factors associated with the development, diagnosis, quantification, and clinical management of this difficult condition. (
  • This webpage provides an evidence-based resource for healthcare professionals caring for patients with underlying medical conditions who are at higher risk of developing severe outcomes of COVID-19. (
  • Although age is the strongest risk factor for severe COVID-19 outcomes, patients with certain underlying medical conditions are also at higher risk. (
  • The more underlying conditions a person has, the higher the risk for severe COVID-19 outcomes. (
  • High-dose melphalan 200 mg/m2 was used for conditioning. (
  • The first international, multicenter trial of the Edmonton Protocol - a standardized approach to the transplantation of insulin-producing islets - demonstrates that this may be an appropriate therapy that can dramatically benefit certain patients with severe complications of Type 1 diabetes mellitus. (
  • The results of the trial show the feasibility and reproducibility of islet transplantation using the Edmonton Protocol and has promising implications for the future of treating type 1 diabetes," says NIH Director Elias A. Zerhouni, M.D. (
  • This really shows that islet transplantation can be tremendously successful in protecting against hypoglycemic unawareness," says Dr. Shapiro. (
  • See how much you know about organ donation and transplantation by taking this quiz. (
  • One common approach to 'bridge' higher-risk MDS from the time of diagnosis to transplantation is a treatment with hypomethylating agents such as azacitidine due to its anticipated low toxicity profile. (
  • The interval from diagnosis to transplantation was 3 to 328 months (median, 14.6 months). (
  • Thus, low-dose TBI + CY + ATG conditioning resulted in excellent outcome of unrelated transplants in patients with aplastic anemia who had received multiple transfusions. (
  • Patients selected for heart transplants have severe end-stage heart failure that is caused by a variety of cardiovascular diseases, hereditary conditions and viral infections of the heart. (
  • Here, using 20 generations of experimental evolution followed by three generations of reciprocal transplants, we investigated the relationship between adaptation and plasticity in the marine copepod, Acartia tonsa , in future global change conditions (high temperature and high CO 2 ). (
  • 3] Collected cord blood is cryopreserved and then stored in a cord blood bank for future transplantation. (
  • In recent years trials with cord blood have showed promise for treating more common childhood conditions, such as cerebral palsy, autism, and others. (
  • This condition may be underdiagnosed because its symptoms are similar to those of other lung disorders such as asthma, bronchitis, and chronic obstructive pulmonary disease. (
  • It's a chronic condition. (
  • If you have any chronic health conditions or you are a pregnant woman , then you should consult your doctor before getting the hepatitis vaccine. (
  • This condition does not become chronic or long-term infection. (
  • Global conditions are changing at a geologically unprecedented rate, and the frequency of extreme events is increasing due to human activities resulting in chronic and novel environmental changes 1 . (
  • In other words, common things are common-with pulmonary hypertension related to left heart condition (WHO group II) or chronic lung disease/hypoxemia (WHO group III) being the two most common causes of pulmonary hypertension. (
  • Older adults take many over-the-counter and prescription medications for chronic medical conditions and disorders. (
  • 2 underlying conditions and reflected the to World Health Organization guidelines and public groups at risk for infection with Legionella spp. (
  • These oral conditions can become a source of infection since patients with CKD are highly susceptible due to the immunodeficiency caused by uremia 3 . (
  • This infection is a silent killer, because the individual who is affected with this condition doesn't experience any symptoms. (
  • Conditioning or preparative treatment takes place before transplantation of haematopoietic progenitor cells - the cells that make blood cells. (
  • This condition causes blood in the urine. (
  • En route to the hospital a cardiac monitor showed changes consistent with a heart attack and the FF's blood pressure began to fall. (
  • Due to his critical condition (cardiogenic shock) the FF was not considered a surgical candidate and was given aggressive medical management which included endotracheal intubation, intravenous (IV) fluids, IV medications, and placement of an intra-aortic balloon pump for blood pressure support. (
  • The red cell sickling and poor oxygen delivery can also cause organ damage over time and anemia, a blood condition which makes you feel tired or weak. (
  • Stem cells are a type of unspecialized cell that can change into a more specialized cell, such as a healthy red blood cell, under certain conditions. (
  • Numerous medical conditions can cause hair loss, including thyroid disease and autoimmune diseases such as lupus. (