Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.
The transference of a part of or an entire liver from one human or animal to another.
A general term referring to the learning of some particular response.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The transference of a kidney from one human or animal to another.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Reflex closure of the eyelid occurring as a result of classical conditioning.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Transplantation of an individual's own tissue from one site to another site.
The transference of a heart from one human or animal to another.
The transference of either one or both of the lungs from one human or animal to another.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The affective response to an actual current external danger which subsides with the elimination of the threatening condition.
Transference of an organ between individuals of the same species or between individuals of different species.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced.
The transference of a pancreas from one human or animal to another.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
Brief closing of the eyelids by involuntary normal periodic closing, as a protective measure, or by voluntary action.
Elements of limited time intervals, contributing to particular results or situations.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
The principle that items experienced together enter into a connection, so that one tends to reinstate the other.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
An induced response to threatening stimuli characterized by the cessation of body movements, except for those that are involved with BREATHING, and the maintenance of an immobile POSTURE.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
The return of a sign, symptom, or disease after a remission.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
The maintenance of certain aspects of the environment within a defined space to facilitate the function of that space; aspects controlled include air temperature and motion, radiant heat level, moisture, and concentration of pollutants such as dust, microorganisms, and gases. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.
The procedure of presenting the conditioned stimulus without REINFORCEMENT to an organism previously conditioned. It refers also to the diminution of a conditioned response resulting from this procedure.
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A response to a cue that is instrumental in avoiding a noxious experience.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Transplantation between animals of different species.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Prospective patient listings for appointments or treatments.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The observable response an animal makes to any situation.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Partial or total replacement of the CORNEA from one human or animal to another.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Use of sound to elicit a response in the nervous system.
A change in electrical resistance of the skin, occurring in emotion and in certain other conditions.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
A dead body, usually a human body.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Pathological processes of the LIVER.
Animal searching behavior. The variable introductory phase of an instinctive behavior pattern or sequence, e.g., looking for food, or sequential courtship patterns prior to mating.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Disease having a short and relatively severe course.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Immunological rejection of tumor tissue/cells following bone marrow transplantation.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
Signals for an action; that specific portion of a perceptual field or pattern of stimuli to which a subject has learned to respond.
Providers of tissues for transplant to non-related individuals.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
Progenitor cells from which all blood cells derive.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
A complex involuntary response to an unexpected strong stimulus usually auditory in nature.
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.
Immunological rejection of leukemia cells following bone marrow transplantation.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
The volatile portions of substances perceptible by the sense of smell. (Grant & Hackh's Chemical Dictionary, 5th ed)
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Use of electric potential or currents to elicit biological responses.
The transference of a complete HAND, as a composite of many tissue types, from one individual to another.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
The period following a surgical operation.
Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A fold of the mucous membrane of the CONJUNCTIVA in many animals. At rest, it is hidden in the medial canthus. It can extend to cover part or all of the cornea to help clean the CORNEA.
Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.
Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.
Disorders of the blood and blood forming tissues.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
The strengthening of a conditioned response.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
The persistence to perform a learned behavior (facts or experiences) after an interval has elapsed in which there has been no performance or practice of the behavior.
An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Four clusters of neurons located deep within the WHITE MATTER of the CEREBELLUM, which are the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
An individual that contains cell populations derived from different zygotes.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
The induction of prolonged survival and growth of allografts of either tumors or normal tissues which would ordinarily be rejected. It may be induced passively by introducing graft-specific antibodies from previously immunized donors, which bind to the graft's surface antigens, masking them from recognition by T-cells; or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity.
A monosynaptic reflex elicited by stimulating a nerve, particularly the tibial nerve, with an electric shock.
The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Tissues, cells, or organs transplanted between genetically different individuals of the same species.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
Antibodies produced by a single clone of cells.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
A genus of dextrally coiled freshwater snails that includes some species of importance as intermediate hosts of parasitic flukes.
Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.
A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
Remembrance of information from 3 or more years previously.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
The relationship between the dose of an administered drug and the response of the organism to the drug.
An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure.
The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.
The time from the onset of a stimulus until a response is observed.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Tumors or cancer of the LIVER.

Early harvest and late transplantation as an effective therapeutic strategy in multiple myeloma. (1/1881)

Transplantation after high-dose chemotherapy prolongs survival in patients with multiple myeloma compared with standard therapy. It is unclear whether the optimal timing of transplantation is immediately after induction chemotherapy or whether stem cells may be cryopreserved for transplantation at subsequent progression or relapse. In this study, stem cells were collected within 6 months of diagnosis, followed by transplantation only at progression of myeloma. One hundred and eighteen patients with multiple myeloma had stem cells collected and cryopreserved. Eleven had transplants early in the disease after they demonstrated failure to respond to primary therapy. The remaining 107 were eligible for transplants when there was evidence of progressive disease. Of the 118 patients, 67 had transplants, nine died of progressive disease before transplantation, and 42 remain alive in plateau phase. The median survival of the group is 58.5 months; 67 are alive. Serum beta2-microglobulin, bone marrow labeling index (S phase), and hemoglobin level predicted overall survival (P < 0.006, P < 0.001, and P < 0.01, respectively). We conclude that early cryopreservation of blood stem cells followed by transplantation at progression is a feasible approach to therapy in patients with myeloma. The underlying biology of the disease has a greater impact on survival than the timing of transplantation. A prospective randomized trial is required to answer definitively the question of the optimal timing of blood cell transplantation.  (+info)

High-dose therapy with autologous or allogeneic transplantation as salvage therapy for small cleaved cell lymphoma of follicular center cell origin. (2/1881)

Between 1985 and 1996, 51 patients with relapsed or refractory small cleaved cell lymphoma (SCCL) received high-dose chemotherapy +/- TBI in conjunction with autologous (ABMT) (36 patients) or allogeneic transplantation (15 patients). Patients were eligible for ABMT if the bone marrow biopsy done prior to the planned transplant did not reveal microscopic involvement with SCCL. Patients receiving ABMT had a median age of 48 years, had received a median of 2.5 chemotherapy regimens prior to transplantation, and were transplanted a median of 35.5 months from diagnosis. Among patients receiving ABMT, 5 year actuarial survival was 56+/-11%. Median survival was 126+ months, and median survival from diagnosis was 191 months. Univariate and multivariate analysis identified sensitive disease as the best predictor of a favorable response. Five-year actuarial survival was 66+/-12% for patients with sensitive disease at the time of transplant as compared to 29+/-17% for patients with resistant disease, P = 0.015. Median survival in patients with sensitive disease at the time of ABMT was 126+ months. By univariate analysis, survival was significantly better for patients receiving ABMT as compared to patients receiving allogeneic transplants. Median survival following allogeneic transplantation was 5 months; 5 year actuarial survival was 15+/-13%. In a multivariate analysis, which considered autologous vs allogeneic transplantation, sensitive vs resistant disease, <3 vs > or = 3 prior treatments, and prior bone marrow involvement, allogeneic transplantation was significantly associated with poor survival. Treatment-related mortality occurred in eight of 15 patients receiving allogeneic transplantation and limited the effectiveness of this therapy. High-dose therapy in conjunction with ABMT is effective therapy for patients with SCCL whose disease is sensitive to chemotherapy and whose marrows are microscopically free of disease. Because of possible selection bias, it has not been proven that this approach increases survival in these patients. Treatment-related mortality limits the effectiveness of allogeneic transplantation in SCCL.  (+info)

Autologous transplantation of chemotherapy-purged PBSC collections from high-risk leukemia patients: a pilot study. (3/1881)

We have recently demonstrated that the combination of the alkylating agent nitrogen mustard (NM) and etoposide (VP-16) is capable of eliminating, ex vivo, leukemic cells contaminating PBSC collections and this is associated with a significant recovery of primitive and committed hematopoietic progenitor cells. Based on these data a pilot study on autologous transplantation of NM/VP-16 purged PBSC for high-risk leukemic patients was recently initiated. Twelve patients (seven females and five males) with a median age of 46 years (range 18-57) have been treated. Two patients had acute myeloblastic leukemia (AML) resistant to conventional induction treatment, four patients had secondary AML in I complete remission (CR), one patient was in II CR after failing a previous autologous BM transplantation, while two additional AML individuals were in I CR achieved after three or more cycles of induction treatment. Two patients with high-risk acute lymphoblastic leukemia (ALL) in I CR and one patient with mantle cell lymphoma and leukemic dissemination were also included. Eight patients showed karyotypic abnormalities associated with a poor clinical outcome. The mobilizing regimens included cytosine arabinoside and mitoxantrone with (n = 6) or without fludarabine (n = 3) followed by subcutaneous administration of G-CSF (5 microg/kg/day until the completion of PBSC collection) and G-CSF alone (n = 3) (15 microg/kg/day). A median of two aphereses (range 1-3) allowed the collection of 7.2 x 10(8) TNC/kg (range 3.4-11.5), 5 x 10(6) CD34+ cells/kg (range 2.1-15.3) and 9.2 x 10(4) CFU-GM/kg (0.3-236). PBSC were treated with a constant dose of 20 microg of VP-16/ml and a median individual-adjusted dose (survival < or = 5% of steady-state BM CFU-GM) of NM of 0.7 microg/ml (range 0.25-1.25). Eleven patients were reinfused after busulfan (16 mg/kg) and Cy (120 mg/kg) conditioning with a median residual dose of 0.3 x 10(4) CFU-GM/kg (0-11.5). The median time to neutrophil engraftment (>0.5 x 10(9)/l) for evaluable patients was 25 days (range 12-59); the median time to platelet transfusion independence (>20 and >50 x 10(9)/l) was 40 days (18-95) and 69 days (29-235), respectively. Hospital discharge occurred at a median of 25 days (18-58) after stem cell reinfusion. Four individuals are alive in CR (n = 3) or with residual nodal disease (n = 1 lymphoma patient) with a follow-up of 32, 26, 3 and 14 months, respectively. Seven patients died due to disease progression or relapse (n = 5) or extrahematological transplant toxicity (n = 2). Our data suggest that pharmacological purging of leukapheresis collections of leukemic patients at high-risk of relapse is feasible and ex vivo treated cells reconstitute autologous hematopoiesis.  (+info)

Ultrasound B-mode changes in the uterus and ovaries and Doppler changes in the uterus after total body irradiation and allogeneic bone marrow transplantation in childhood. (4/1881)

Internal genitalia and uterine blood flow were assessed by ultrasound in 12 females 4.0-10.9 years after total body irradiation and allogeneic bone marrow transplantation for childhood leukaemia or lymphoma. Median age of the participants was 12.7 years (range 6.1-17.6) at bone marrow transplantation and 21.5 years (11.6-25.6) at the follow-up study. At follow-up all had entered puberty and 11/12 females had experienced the menarche. Eight females received sex steroid replacement therapy, three had spontaneous pubertal development and one woman experienced symptoms of estrogen deficiency. Median uterine and ovarian volumes were significantly reduced to -2.6 standard deviation scores (SDS) (-6.3 to -0.6), P = 0.002, and -2.6 SDS (-4.8 to -0.5), P = 0.002, respectively, compared with normal controls. Follicles were only detectable in two individuals. Uterine blood flow was impaired, as a systolic blood flow could be measured in 6/9 individuals, and a diastolic blood flow in 1/9 females. Our results indicate that the prescribed dosage of hormone replacement therapy, which was sufficient to induce bleeding and suppress other stigmata of premature menopause, was inadequate to generate normal uterine growth. In order to achieve uterine growth higher doses of hormone replacement therapy may be required. Our results confirm pelvic ultrasound as a reliable tool for investigation of internal female genitalia; however, in an infertility setting further tests are indicated.  (+info)

Antiemetic efficacy of granisetron plus dexamethasone in bone marrow transplant patients receiving chemotherapy and total body irradiation. (5/1881)

Few trials exist regarding the antiemetic efficacy of granisetron in bone marrow transplant (BMT) recipients conditioned with high-dose chemotherapy and total body irradiation (TBI). In this single-center, open-label, prospective, trial, the antiemetic efficacy and safety of granisetron plus dexamethasone were evaluated in 26 patients conditioned with cyclophosphamide-containing regimens (the majority receiving 60 mg/kg per day on 2 consecutive days), and TBI (12 Gy divided over 4 days). Daily intravenous doses of granisetron 1 mg plus dexamethasone 10 mg were given 30 min prior to chemotherapy or radiation, and continued for 24 h after the last conditioning treatment for a median of 6 days (range 3-9). Emetic control was defined by the number of emetic episodes occurring within a 24 h period, or the requirement for rescue medication for nausea or vomiting. A total of 25 patients completed 186 evaluable treatment days. Response (emetic control by treatment days) was complete in 50% of patients, major in 48%, minor in 2%, and there were no failures. Adverse effects were minor, with diarrhea (15%), headache (14%), and constipation (11%) reported most often. Based on these results, the antiemetic regimen of granisetron plus dexamethasone appears effective and well tolerated during BMT conditioning with high-dose cyclophosphamide and TBI.  (+info)

Adenovirus infection after pediatric bone marrow transplantation. (6/1881)

Retrospective analysis of 206 patients undergoing 215 consecutive bone marrow transplants (BMT) at St Jude Children's Research Hospital between November 1990 and December 1994 identified 6% (seven male, six female) with adenovirus infection. The affected patients had a median age of 7.9 years (range 3-24 years) at time of transplantation. Although transplants were performed for hematologic malignancies, solid tumors or nonmalignant conditions, only patients with hematologic malignancies had adenoviral infections. Adenovirus was first detected at a median of 54 days (range -4 to +333) after BMT. Adenovirus developed in eight of 69 (11.6%) patients receiving grafts from matched unrelated or mismatched related donors, in four of 52 (7.7%) receiving grafts from HLA-matched siblings, and in one of 93 (1.1%) receiving autografts. The most common manifestation of adenovirus infection was hemorrhagic cystitis, followed by gastroenteritis, pneumonitis and liver failure. The incidence of adenovirus infection in pediatric BMT patients at our institution is similar to that reported in adult patients. Using univariate analysis, use of total body irradiation and type of bone marrow graft were significant risk factors for adenovirus infection. Only use of total body irradiation remained as a factor on multiple logistic regression analysis.  (+info)

Fungal prophylaxis by reduction of fungal colonization by oral administration of bovine anti-Candida antibodies in bone marrow transplant recipients. (7/1881)

Candida overgrowth and invasion constitute a serious threat with a high mortality in BMT recipients. Currently available topical antifungal prophylaxis is largely ineffective, and as resistance to existing, absorbable drugs for systemic use is rapidly developing, new forms of therapy are needed. We investigated the effect of oral treatment of BMT recipients with a bovine immunoglobulin product derived from animals immunized against several Candida species. The natural Candida colonization was first followed in 19 patients to establish the colonization pattern. Half of the patients were found to be colonized prior to transplantation and altogether 72% were colonized at some point during follow-up. Those with a high pre-transplant concentration of Candida in saliva (>100 CFU/ml) remained colonized throughout the BMT treatment period. The therapeutic effect was monitored in two other patient groups. The first group consisted of nine patients, where, due to a low number of primary colonized patients, response in colonized patients was suggestive of a therapeutic effect. In the second group, 10 patients with a high level of colonization (>100 CFU/ml) were given 10 g daily of the product in three divided doses. The results suggest a treatment-related reduction in Candida colonization in a majority (7/10) of patients and one patient became completely negative. As no adverse effects were noted, our findings encourage additional studies in immunocompromised, transplant patients.  (+info)

Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy. (8/1881)

A patient with a stage IV mantle cell lymphoma (according to the REAL classification) was treated with high-dose chemotherapy and autologous bone marrow transplantation. One year later while on alpha-interferon immunotherapy she suffered from progressive loss of short-term memory and reported difficulties in recognizing objects. Magnetic resonance imaging (MRI) showed a vast ring-enhancing lesion of the left postcentral parietal area. Serial stereotactic biopsies disclosed progressive multifocal leukoencephalopathy without JC-virus in the cerebrospinal fluid. Therapy with subcutaneous interleukin-2 (IL-2) every other day and intrathecal cytarabine once a week was started. After 4 weeks the patient refused further treatment. Nevertheless her condition improved over the next 8 months and MRI scans showed a marked improvement in the lesions.  (+info)

Our clinical investigations demonstrate, that nonmyeloablative stem cell transplantation (NST) is a novel therapeutic option in patients with high-risk ALL or AML. NST can be administered to patients eligible for allogeneic stem cell transplantation with contraindications against high-dose radio- and chemotherapy (standard SCT). After NST, infections and late onset acute graft-versus-host disease (GvHD) frequently occurred, but transplant-related mortality was low in contrast to standard SCT. Leukemia-free survival and overall survival were similar after NST and standard SCT. A higher relapse rate after NST was balanced by a higher transplant-related mortality after standard SCT. The conditioning regimen itself had no relevant impact on survival. Sequential chimerism analyses of leukocyte subpopulations resulted in early diagnosis of mixed chimerism, which proved to be predictive for later relapses. Stable mixed chimerism was not established in these patients. Adoptive immunotherapy in patients, ...
Allogeneic hematopoietic cell transplantation (HCT) using reduced-intensity conditioning (RIC) regimens is a potentially curative treatment for patients (patients) with myelofibrosis
Johan Törlén, Olle Ringdén, Jennifer Le Rademacher, Minoo Batiwalla, Junfang Chen, Tom Erkers, Vincent Ho, Partow Kebriaei, Carolyn Keever-Taylor, Tamila Kindwall-Keller, Hillard M. Lazarus, Mary J. Laughlin, Michael Lill, Tracey OBrien, Miguel Angel Perales, Vanderson Rocha, Bipin N. Savani, David Szwajcer, David Valcarcel, Mary Eapen ...
Wiskott-Aldrich syndrome (WAS) is an inherited immunodeficiency caused by mutations in the gene encoding WASP that is treated with hematopoietic stem/progenitor cell (HSPC) transplantation. Infusion of autologous HSPCs modified ex vivo by gene therapy is an alternative approach when matched donors are unavailable. Following reduced-intensity conditioning regimen, three WAS patients were infused with autologous HSPCs genetically corrected by […]. ...
If transplantation using mismatched unrelated donors or non-first-degree relatives could be performed with an acceptable toxicity profile, an important unmet need would be served. Towards this goal, the current study extends our platform of nonmyeloablative, partially HLA-mismatched BMT to the use of such donors, investigating up to several postgrafting immunosuppression regimens that incorporate high-dose Cy. Of central interest is the incorporation of sirolimus into this postgrafting immunosuppression regimen. The primary goal is to identify a transplant regimen associated with acceptable rates of severe acute GVHD and NRM by Day 100 ...
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The study aimed to evaluate the impact of myeloablative (MAC) versus reduced intensity conditioning (RIC) regimen on allo-HSCT outcomes in patients with t-AML
TY - JOUR. T1 - Long-Term Follow-Up after Reduced-Intensity Conditioning and Stem Cell Transplantation for Childhood Nonmalignant Disorders. AU - Madden, Lisa M.. AU - Hayashi, Robert J.. AU - Chan, Ka Wah. AU - Pulsipher, Michael A.. AU - Douglas, Dorothea. AU - Hale, Gregory A.. AU - Chaudhury, Sonali. AU - Haut, Paul. AU - Kasow, Kimberly A.. AU - Gilman, Andrew L.. AU - Murray, Lisa M.. AU - Shenoy, Shalini. PY - 2016/8/1. Y1 - 2016/8/1. N2 - Reduced-intensity conditioning (RIC) before hematopoietic stem cell transplantation (HCT) in children could result in fewer complications during follow-up compared with myeloablative regimens. Hence, many RIC regimens are under investigation, but long-term follow-up is essential. We describe late follow-up beyond 2 years post-HCT in 43 children with nonmalignant disorders who underwent related or unrelated donor (56%) HCT on a multicenter study using a RIC regimen (alemtuzumab, fludarabine, and melphalan) followed by bone marrow (n = 30), peripheral ...
BM failure (BMF) is a major and frequent complication of dyskeratosis congenita (DKC). Allogeneic hematopoietic SCT (allo-HSCT) represents the only curative treatment for BMF associated with this condition. Transplant-related morbidity-mortality is common especially after myeloablative conditioning regimens. Herein, we report nine cases of patients with DKC who received an allo-SCT at five different member centers within the Eastern Mediterranean Blood and Marrow Transplantation Registry. Between October 1992 and February 2011, nine DKC patients (male, 7 and female, 2), with a median age at transplantation of 19.1 (4.9-31.1) years, underwent an allo-HSCT from HLA-matched, morphologically normal-related donors (100percent). Preparative regimens varied according to different centers, but was reduced intensity conditioning (RIC) in eight patients. Graft source was unstimulated BM in five cases (56percent) and G-CSF-mobilized PBSCs in four (44percent) cases. The median stem cell dose was 6.79 ...
ContextA minimally toxic nonmyeloablative regimen was developed for allogeneic hematopoietic cell transplantation (HCT) to treat patients with advanced hematolo
In this multicenter retrospective study, the outcomes of 836 patients with myelodysplastic syndrome (MDS) who underwent transplantation with a human leukocyte antigen (HLA)-identical sibling donor were analyzed according to 2 types of conditioning: reduced-intensity conditioning (RIC) in 215 patients, and standard myeloablative (or high-dose) conditioning (SMC) in 621 patients. In multivariate analysis, the 3-year relapse rate was significantly increased after RIC (hazard ratio [HR], 1.64; 95% confidence interval [95% CI], 1.2-2.2; P = .001), but the 3-year nonrelapse mortality (NRM) rate was decreased in the RIC group (HR, 0.61; 95% CI, 0.41-0.91; P = .015). The 3-year probabilities of progression-free and overall survivals were similar in both groups (39% after SMC vs 33% in RIC; multivariate P = .9; and 45% vs 41%, respectively; P = .8). In conclusion, the lower 3-year NRM after RIC is encouraging, since these patients were older (age > 50 years in 73% RIC vs 28% in SMC, P < .001) and ...
The use of myeloablative conditioning (MAC) in umbilical cord blood transplantation (UCBT) has been associated with high nonrelapse mortality (NRM) in patients aged ,40 years, especially those having a high HLA disparity, thus limiting wider applications. We hypothesized that the NRM advantage of reduced-intensity conditioning (RIC) and higher graft-versus-leukemia effect associated with greater HLA disparities would expand its use for patients (aged 40 to 60 years) without compromising efficacy and compared outcomes between RIC and MAC regimens. In total, 288 patients aged 40 to 60 years, with de novo acute myeloid leukemia, receiving UCBT with at least 2 HLA mismatches with RIC (n = 166) or MAC (n = 122) regimens were included. As compared to RIC, the MAC cohort included relatively younger patients, having received more single UCBT, with lower total nucleated cell counts and more in vivo T cell depletion. Median time to neutrophil engraftment, infections (bacterial, viral, and fungal), and ...
Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic ...
The initial trials of reduced intensity allogeneic hematopoietic cell transplantation regimens for metastatic renal cell carcinoma have generated considerable interest because responses were observed in patients who had experienced progressive disease after conventional immunotherapy (13, 14, 15 , 17 , 18) , and some of these responses have been durable for ,4 years (46) . However, despite the use of reduced intensity conditioning regimens, the management of conditioning-related toxicity generally required inpatient care, and treatment-related complications have been responsible for deaths in 11 to 33% of patients treated in this fashion (13, 14, 15, 16, 17 , 47) . The low toxicity of the fludarabine/total body irradiation conditioning regimen combined with posttransplant cyclosporine/mycophenolate mofetil has been established in patients with hematologic malignancies (12 , 21 , 23) . This study confirms the limited toxicity of this conditioning regimen in patients with metastatic renal cell ...
Abstract. BACKGROUND: Chronic GVHD is a major determinant of quality of life after allogeneic HCT. Systemic immunosuppressants (IS) are the mainstay of treatme
To test the safety, and efficacy of Fludarabin and TBI combination for myeloablative conditioning for elderly patients with hematological malignancies (phase
Thiotepa-Containing Conditioning Regimens Improve Survival Outcomes in Patients With PCNSL - ASH Annual Meeting, Lymphomas & Lymphoid Neoplasia, Meeting News, On Location - ASH Clinical News
Complete title: A Randomized Phase II Study to Compare the Net Clinical Benefit of Cyclosporine and Sirolimus combined with MMF or Post-Transplant Cyclophosphamide as GVHD Prophylaxis after HLA-Matched or HLA-Mismatched Unrelated G-CSF Mobilized Blood Cell Transplantation using Nonmyeloablative or Reduced Intensity Conditioning for Patients with Hematologic Malignancies: A Multi-Center ...
Die Universität zu Köln ist eine Exzellenzuniversität mit dem klassischen Fächerspektrum einer Volluniversität. Als eine der größen Hochschulen Europas arbeitet sie in Forschung und Lehre auch international auf höchstem Niveau.
Molecular Templates to receive $38 million upfront payment, including equity investment, with potential for additional milestone and royalty payments on future
*Laboratory Findings Prior to the Start of the Preparative Regimen / Infusion: For questions 80 - 97, report all findings within two months prior to the start...
TY - JOUR. T1 - Infectious complications following nonmyeloablative allogeneic hematopoietic stem cell transplantation. AU - Busca, Alessandro. AU - Locatelli, F.. AU - Barbui, A.. AU - Ghisetti, V.. AU - Cirillo, D.. AU - Serra, R.. AU - Audisio, E.. AU - Falda, M.. PY - 2003/9. Y1 - 2003/9. N2 - Nonmyeloablative hematopoietic stem cell transplantation (NST) has been explored in hematological malignancies and solid tumors in an attempt to minimize treatment-related toxicity. Whether this approach is associated with reduced risk of infectious complications is unclear. The aim of the current study was to evaluate the infectious complications in a series of 32 consecutive adult patients who received NSTat our institution. Peripheral blood stem cell grafts (n = 30) or marrow grafts (n = 2) were infused from human leukocyte antibody (HLA)·matched sibling (n = 30), partially matched related (n = 1), or unrelated (n = 1) donors. Neutropenia developed in two-thirds of patients and lasted 16 days. ...
Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted, 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations. © 2006 The Authors.. ...
Reduced intensity conditioning (RIC) regimens have allowed older patients and those with comorbidities to receive hematopoietic cell transplantation (HCT). We analyzed medical costs from the beginning of conditioning to 100 days after HCT for 484 patients and up to 2 years for 311 patients who underwent a RIC HCT at two institutions from January 2008 to December 2010. Multiple linear regression was used to analyze the association between clinical variables, center effect, and costs. Patient and transplant characteristics were comparable between the sites, although differences were seen in pretransplant performance scores. Significant predictors for lower costs for the first 100 days included a diagnosis of lymphoma/myeloma and use of human leukocyte antigen-matched related donors. Grade II-IV acute graft-versus-host disease (GVHD) was associated with higher costs. The overall short-term costs between the two institutions were comparable when adjusted for clinical variables (p = .43). Late costs ...
TY - JOUR. T1 - Rapid immune reconstitution following autologous hematopoietic stem cell transplantation in children. T2 - A single institution experience. AU - Hoepfner, S.. AU - Haut, Paul. AU - OGorman, M.. AU - Kletzel, M.. PY - 2003/2. Y1 - 2003/2. N2 - In this retrospective study, we review the immune reconstitution of children undergoing autologous hematopoietic stem cell transplantation. A total of 125 patients underwent autologous transplantation between 1992 and 2000. The report includes data on 58 patients. Data were not available on the remaining patients who either died before testing or data were not obtained. The parameters evaluated include: (a) immunophenotype by flow cytometry to quantify lymphocyte subpopulations (b) mitogen stimulation assays, and (c) quantitative immunoglobulins. The analysis reveals that CD3+ cells did not reach the normal range during the first year post-transplant. The median percentage of CD4 + cells was below normal up to 6 months post-transplant, ...
TY - JOUR. T1 - Long-term follow-up of reduced-intensity allogeneic hematopoietic stem cell transplantation for refractory or relapsed follicular lymphoma. AU - Ono, Yukako. AU - Mori, Takehiko. AU - Kato, Jun. AU - Yamane, Akiko. AU - Shimizu, Takayuki. AU - Kikuchi, Taku. AU - Kohashi, Sumiko. AU - Okamoto, Shinichiro. PY - 2012/9. Y1 - 2012/9. UR - http://www.scopus.com/inward/record.url?scp=84865355006&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84865355006&partnerID=8YFLogxK. U2 - 10.1002/ajh.23261. DO - 10.1002/ajh.23261. M3 - Article. C2 - 22674621. AN - SCOPUS:84865355006. VL - 87. SP - 929. EP - 931. JO - American Journal of Hematology. JF - American Journal of Hematology. SN - 0361-8609. IS - 9. ER - ...
The purpose of this study is to evaluate the outcome of imatinib combined with reduced-intensity allogeneic hematopoietic stem cell transplantation versus
TY - JOUR. T1 - Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome. AU - Muramatsu, Hideki. AU - Sakaguchi, Hirotoshi. AU - Taga, Takashi. AU - Tabuchi, Ken. AU - Adachi, Souichi. AU - Inoue, Masami. AU - Kitoh, Toshiyuki. AU - Suminoe, Aiko. AU - Yabe, Hiromasa. AU - Azuma, Eichi. AU - Shioda, Yoko. AU - Ogawa, Atsushi. AU - Kinoshita, Akitoshi. AU - Kigasawa, Hisato. AU - Osugi, Yuko. AU - Koike, Kazutoshi. AU - Kawa, Keisei. AU - Kato, Koji. AU - Atsuta, Yoshiko. AU - Kudo, Kazuko. PY - 2014/5. Y1 - 2014/5. N2 - Allogeneic hematopoietic stem cell transplantation (HSCT) has not been widely used in patients with acute myeloid leukemia (AML) and Down syndrome (DS) due to fear of transplantation-related toxicity. A retrospective analysis of the outcome of allogeneic HSCT was conducted in 15 patients with AML and DS. The five patients transplanted with the reduced intensity conditioning (4 in complete remission (CR) and 1 in non-CR) had a ...
Ringden, O.; Labopin, M.; Schmid, C.; Sadeghi, B.; Polge, E.; Tischer, J.; Ganser, A.; Michallet, M.; Kanz, L.; Schwerdtfeger, R.; Nagler, A.; Mohty, M. (2016): Sequential chemotherapy followed by reduced intensity conditioning and allogeneic hematopoietic stem cell transplantation in adult patients with relapse or refractory acute myeloid leukemia (AML): a survey from the Acute Leukemia Working Party of EBMT. In: Bone Marrow Transplantation, Vol. 51: S476-S477 ...
After autologous hematopoietic cell transplantation (HCT) in the first complete remission (CR1), patients with acute myeloid leukemia (AML) may relapse and undergo allogeneic HCT in the second complete remission (CR2). The aim of this study was to analyze the outcome of allogeneic HCT performed in CR2 comparing patients with prior consolidation by autologous HCT versus patients with chemotherapy consolidation. Included were 2619 adults with allogeneic HCT in CR2 from 2000 to 2017 with (n = 417) or without (n = 2202) prior autologous HCT. Patient groups were not entirely comparable; patients with prior autologous HCT were younger, had less often a favorable cytogenetic profile, had more commonly donors other than matched siblings, and more often received reduced-intensity conditioning. In multivariate analysis, nonrelapse mortality risks in patients with prior autologous HCT were 1.34 (1.07 to 1.67; P =.01) after adjustment for age, cytogenetic risk, transplant year, donor, conditioning ...
TY - JOUR. T1 - Allogeneic hematopoietic cell transplantation for patients with TP53 mutant or deleted chronic lymphocytic leukemia. T2 - Results of a prospective observational study. AU - Schetelig, Johannes. AU - Hoek, Jennifer. AU - Stilgenbauer, Stephan. AU - Middeke, Jan Moritz. AU - Andersen, Niels Smedegaard. AU - Fox, Christopher P.. AU - Lenhoff, Stig. AU - Volin, Liisa. AU - Shimoni, Avichai. AU - Schroyens, Wilfried. AU - van Gelder, Michel. AU - Bunjes, Donald. AU - van Biezen, Anja. AU - Baldauf, Henning. AU - de Wreede, Liesbeth C.. AU - Tournilhac, Olivier. AU - Kroeger, Nicolaus. AU - Yakoub-Agha, Ibrahim. AU - Dreger, Peter. PY - 2020/8/16. Y1 - 2020/8/16. KW - FOLLOW-UP. KW - RETROSPECTIVE ANALYSIS. KW - EUROPEAN-SOCIETY. KW - CLL. KW - BLOOD. U2 - 10.1038/s41409-020-01013-y. DO - 10.1038/s41409-020-01013-y. M3 - Letter. JO - Bone Marrow Transplantation. JF - Bone Marrow Transplantation. SN - 0268-3369. ER - ...
PubMed journal article: Effect of graft source on unrelated donor hemopoietic stem cell transplantation in adults with acute myeloid leukemia after reduced-intensity or nonmyeloablative conditioning: a study from the Société Francaise de Greffe de Moelle et de Thérapie Cellulaire. Download Prime PubMed App to iPhone, iPad, or Android
PURPOSE: Age has long been used as a major factor for assessing suitability for allogeneic hematopoietic cell transplantation (HCT). The HCT-comorbidity index (HCT-CI) was developed as a measure of health status to predict mortality risk after HCT. Whether age, comorbidities, or both should guide decision making for HCT is unknown. PATIENTS AND METHODS: Data from 3,033 consecutive recipients of HLA-matched grafts from five institutions contributed to this analysis. Patients were randomly divided into a training set to develop weights for age intervals and a validation set to assess the performance of prognostic models. RESULTS: In the training set, patients age 20 to 39 years, 40 to 49 years, 50 to 59 years, and ≥ 60 years had hazard ratios for nonrelapse mortality (NRM) of 1.21 (P = .29), 1.48 (P = .04), 1.75 (P = .004), and 1.84 (P = .005), respectively, compared with those age younger than 20 years. Consequently, age ≥ 40 years was assigned a weight of 1 to be added to the HCT-CI to ...
Clinical trial for Multiple Myeloma , Autologous Stem Cell Transplant (ASCT) With Intravenous Busulfan and Melphalan as Conditioning Regimen
This trial will evaluate the efficacy and the safety of a strategy of allogeneic stem cell transplantation including Rituximab in the conditioning regim
Transforming growth factor β-1, encoded by the TGFB1 gene, is a cytokine that plays a central role in many physiologic and pathogenic processes. We have sequenced TGFB1 regulatory region and assigned allelic genotypes in a large cohort of hematopoietic stem cell transplantation patients and donors. In this study we analyzed 522 unrelated donor-patient pairs and examined the combined effect of all the common polymorphisms in this genomic region. In univariate analysis, we found that patients carrying a specific allele, p001, showed significantly reduced overall survival (5-year overall survival 30.7% for p001/p001 patients vs 41.6% others; p=0.032) and increased non-relapse mortality (1-year non-relapse mortality: 39.0% vs 25.4%; p=0.039) after transplantation. In multivariate analysis, the presence of a p001/p001 genotype in patients was confirmed as an independent factor for reduced overall survival (hazard ratio=1.53 [1.04-2.24]; p=0.031), and increased non-relapse mortality (hazard ...
Results from a randomized, double-blind, placebo-controlled trial show that letermovir protects from viral infection in CMV-seropositive individuals following allogeneic hematopoietic cell transplantation.
BACKGROUND: Allogeneic hematopoietic cell transplantation (HCT) offers curative potential to a number of older patients with acute myeloid leukemia (AML) in their first complete remission. However, there are limited data in the literature concerning post-HCT outcomes for older patients in their second complete remission (CR2). METHODS: The purpose of the current study was to retrospectively investigate within the Center for International Blood and Marrow Transplant Research database parameters influencing posttransplant outcomes for patients 60 years of age or older undergoing HCT for AML in CR2. RESULTS: In total, 196 patients from 78 centers were identified; the median age was 64 years (range, 60-78 years). Seventy-one percent had a Karnofsky performance status ≥ 90 at the time of HCT. Reduced-intensity conditioning regimens were used in 159 patients (81%). A univariate analysis demonstrated a 3-year overall survival (OS) rate of 42% (95% confidence interval [CI], 35%-49%), a leukemia-free ...
Looking for hematopoietic cell transplantation? Find out information about hematopoietic cell transplantation. The artificial removal of part of an organism and its replacement in the body of the same or of a different individual. To remove a plant from one location... Explanation of hematopoietic cell transplantation
Autologous Hematopoietic Stem Cell Transplantation in 48 Patients With End-Stage Chronic Liver Diseases The only presently viable treatment for end-st...
Clinical trial for Aplastic Anemia , Study of Fludarabine + Cyclophosphamide + TBI Conditioning Regimen for Double Units Cord Blood Transplantation(CBT)in Severe Aplastic Anemia(SAA)
Twenty-three leukaemia patients with a median age of 41 years (range 21-64) were enrolled into and treated on this trial from sites in Canada, Belgium, Germany and the United Kingdom. Patients were eligible for an allogeneic hematopoietic stem cell transplantation (HSCT) but could not find a matching donor in time. Sixteen patients had acute myeloid leukaemia (AML) and seven had acute lymphoblastic leukaemia (ALL). Patients were either in first or second complete remission at the time of the HSCT and the majority of patients (57%) had a poor prognosis based on their disease risk index and cytogenetic profile. A myeloablative conditioning regimen was used and (haploidentical) donor grafts were depleted of T-cells (CD34+ selection) prior to transplantation. Patients engrafted rapidly (median 12 days) and ATIR101™ was subsequently infused at a fixed dose of 2×106 CD3+ cells/kg at a median of 28 days post-transplant.. The median follow-up, on March 24, 2016, was 414 days (range 110 - 742) ...
The chemotherapy or irradiation given immediately prior to a transplant is called the conditioning or preparative regimen. The purpose is to help eradicate the patients disease prior to the infusion of HSC and to suppress immune reactions. Chemotherapy drugs and radiation both damage DNA in the cell nucleus which kills rapidly dividing cells by triggering a self-destruct mechanism called apoptosis. Bone marrow cells divide frequently and are particularly sensitive to this treatment. The bone marrow can be ablated at doses that cause minimal injury to other tissues. In allogeneic transplants a combination of cyclophosphamide with busulfan or total body irradiation is commonly employed. This treatment also has an immunosuppressive effect which prevents rejection of the HSC by the recipients immune system. Autologous transplants may also use these conditioning regimens but many other chemotherapy combinations can be used depending on the type of disease. Non-myeloablative allogeneic HSCT is a ...
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The Pretransplantation Assessment of Mortality (PAM) score is a risk score for mortality after allogeneic hematopoietic SCT (HSCT). Ethnicity is a genetically determined factor that correlated with immune-mediated outcomes of allogeneic HSCT. We evaluated the predictive value of the PAM score for transplant outcome in 276 Japanese populations in which transplant-related complications occur less frequently than Caucasians. The PAM score effectively risk-stratified these patients for survival; overall survival (OS) at 2 years was 100%, 80.2%, 49.4%, and 13.9% in the categories 1, 2, 3, and 4, respectively, showing a clear distinction of OS by categories (P|0.001). In addition, the PAM score is useful for the prediction of transplant outcomes both in patients with standard-risk underlying diseases and those with high-risk diseases. The PAM score developed in Caucasian populations is thus useful in non-Caucasian populations.
Abstract. Introduction: Early response rates to non-myeloablative therapy are encouraging, however long term remissions remain elusive. Manipulating donor lymp
New conditioning regimens are still needed to maximize efficacy and limit treatment-related deaths of allogeneic transplantation for advanced hematologi
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The preparative or conditioning regimen is a critical element in the hematopoietic cell transplant procedure. The purpose of the preparative regimen is twofold:To provide adequate immunosuppression to prevent rejection of the transplanted graftTo era
For patients with advanced disease, the challenge is two-fold: Since older patients will be prepared for transplantation with RIC regimens, providing a less cytotoxic component and a lesser debulking effect than is achievable with high-intensity conditioning regimen, it appears advisable (although no controlled data exist) to use debulking therapy before transplantation. Several retrospective analyses have attempted to determine the impact of pre-transplant therapy, particularly with HMAs. It is premature to draw firm conclusions, again, because no controlled studies are available. Clinical wisdom, however, holds that a debulking attempt is indicated in patients with 5% myeloblasts or more who are heading for a RIC transplant regimen. Classically, induction-type chemotherapy has been used which historically has been associated with mortality in the range of 10% or even higher. The advent of HMAs offers an alternative. They are well tolerated, and 40% to 50% of patients derive clinically relevant ...
Hematopoietic Cell Transplantation - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.
While all three types can replenish a patients blood and bone marrow cells, there are advantages and disadvantages to each. The doctor will suggest the best type of stem cell for your childs illness.. The next step in the transplantation process is conditioning therapy, which kills unhealthy cells (like cancer cells) to make room for stem cells to grow and/or weakens the immune system so that theres less chance of the body rejecting the new cells.. One type of conditioning therapy delivers high doses of chemotherapy and/or radiation to kill cells, destroy the bone marrow, and weaken the immune system. Most kids will get this type of therapy. Another type of conditioning therapy delivers lower doses of chemotherapy, radiation, or another treatment to weaken the immune system. The doctor will decide which type of conditioning therapy is best.. Soon after the conditioning phase, the transplant itself will be done through intravenous (IV) infusion, and healthy stem cells will be introduced to the ...
Curr Res Transl Med. 2016 Apr-Jun;64(2):107-13. doi: 10.1016/j.retram.2016.03.004. Epub 2016 Jun 1. Resetting the immune response after autologous hematopoietic stem cell transplantation for autoimmune diseases. Arruda LC1, Clave E2, Moins-Teisserenc H2, Douay C2, Farge D3, Toubert A2. Author information Abstract
Curr Res Transl Med. 2016 Apr-Jun;64(2):107-13. doi: 10.1016/j.retram.2016.03.004. Epub 2016 Jun 1. Resetting the immune response after autologous hematopoietic stem cell transplantation for autoimmune diseases. Arruda LC1, Clave E2, Moins-Teisserenc H2, Douay C2, Farge D3, Toubert A2. Author information Abstract
There are few treatment options for advanced CLL. Standard transplants, which involve powerful doses of pre-transplant chemotherapy to wipe out as much of the leukemia as possible, have proven too toxic for older patients and those with co-existing diseases. Over the past decade, researchers have developed reduced-intensity conditioning (RIC) regimens, using lower chemotherapy doses that are more tolerable but rely entirely on the activity of the transplanted immune cells to battle the leukemia. Usually this is insufficient to keep the cancer at bay long-term and the disease progresses ...
Introduction: Cardiotoxicity is a relatively frequent and potentially serious complication of antitumor treatment. Anthracyclines and other high-dose
Schlenk, R F; Taskesen, E; van Norden, Y; Krauter, J; Ganser, A; Bullinger, L; Gaidzik, V I; Paschka, P; Corbacioglu, A; Göhring, G; Kündgen, A; Held, G; Götze, K; Vellenga, E; Kuball, J; Schanz, U; Passweg, J; Papst, T; Maertens, J; Ossenkoppele, G J; Delwel, R; Döhner, H; Cornelissen, J J; Döhner, K; Löwenberg, B (2013). The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA. Blood, 9(122):1576-1582.. Lugthart, S; Gröschel, S; Beverloo, H B; Kayser, S; Valk, P J; van Zelderen-Bhola, S L; Ossenkoppele, G J; Vellenga, E; van den Berg-de Ruiter, E; Schanz, U; Verhoef, G; Vandenberghe, P; Ferrant, A; Köhne, C H; Pfreundschuh, M; Horst, H A; Schlegelberger, H; Jotterand, M; Krauter, J; Pabst, T; Theobald, M; Schlenk, R F; Delwel, R; Döhner, K; Löwenberg, B; Döhner, H (2010). Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q ...
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A newer treatment approach, nonmyeloablative allogeneic transplantation, also termed reduced-intensity conditioning (RIC), uses ... Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... conditioning in patients with CNS involvement by non-Hodgkin lymphoma". Biology of Blood and Marrow Transplantation. 18 (1): 76 ... "Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning". Journal of ...
In chemotherapy as a conditioning regimen in hematopoietic stem cell transplantation, a study of patients conditioned with ... "Biology of Blood and Marrow Transplantation. 15 (12): 1628-33. PMC 2861656 . PMID 19896087. doi:10.1016/j.bbmt.2009.07.004.. ... Chemotherapy drugs are also used in conditioning regimens prior to bone marow transplant (hematopoietic stem cell transplant). ... under certain conditions, cells stress can induce changes in gene expression that enables resistance to several types of drugs. ...
In chemotherapy as a conditioning regimen in hematopoietic stem cell transplantation, a study of people conditioned with ... "Defining the intensity of conditioning regimens: working definitions". Biology of Blood and Marrow Transplantation. 15 (12): ... Twelve years before the pharmacist was diagnosed with the condition, she had worked for 20 months in a hospital where she was ... Drugs used in chemotherapy can induce cell stress, which can kill a cancer cell; however, under certain conditions, cells ...
"Cardiac transplantation: since the first case report". Grand Rounds. Archived from the original on 2010-10-23. Riley DS, Barber ... "Share and Find Treatment Reviews for Medical Conditions". Treatment Report. Archived from the original on 2016-07-29. " ...
It can also involve bone marrow transplantation. Information on prognosis is limited by the rarity of the condition. Prognosis ... 64-70% of people with this condition are male, and most are elderly, with a median age of 65. The first known case of acute ... Di Guglielmo was the first to recognize the leukemic nature of the condition, and it is sometimes referred to as Di Guglielmo's ...
The condition may also occur without any clear reason. The most commonly affected bone is the femur. Other relatively common ... Other risk factors include radiation therapy, chemotherapy, and organ transplantation. Osteonecrosis is also associated with ... Under favorable conditions, the remaining inorganic mineral volume forms a framework for establishment of new, fully functional ... The condition may also occur without any clear reason. Bisphosphonates are associated with osteonecrosis of the mandible. ...
Caimi G, Canino B, Lo Presti R, Urso C, Hopps E (2017). "Clinical conditions responsible for hyperviscosity and skin ulcers ... Experimental and Clinical Transplantation. 13 (3): 290-4. doi:10.6002/ect.2014.0013. PMID 24679054. ... Cryofibrinogenemia refers to a condition classified as a fibrinogen disorder in which the chilling of an individual's blood ... The clotting disease is commonly grouped with the asymptomatic condition in the term cryofibrinogenmia but is here termed ...
This condition was first described in 2012. Gámez-Díaz L, August D, Stepensky P, Revel-Vilk S, Seidel MG, Noriko M, Morio T, ... These include hematopoietic stem cell transplantation, immunoglobulin replacement and immunosuppressive treatment. ... LPS-responsive beige-like anchor protein deficiency is a rare genetic condition caused by the absence of LPS-responsive beige- ... like anchor protein (LRBA). The presentation of this condition is variable making the diagnosis difficult. The most common ...
The only definitive treatment for this condition currently is lung transplantation. Median survival without treatment is 3 ... This condition was first described in 1978. This condition has been reported in cats. and dogs. Ortiz-Bautista C, Hernández- ... Pulmonary veno-occlusive disease This condition has been reported in patients with Ehlers Danlos syndrome, CREST syndrome and ...
During the exam, the ophthalmologist will examine the eye and diagnose the condition. The doctor will then discuss the ... Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced ... Corneal transplantation. Cornea transplant approximately one week after surgery. Multiple light reflections indicate folds in ... The corneal transplantation is performed when medicines, keratoconus conservative surgery and cross-linking cannot heal the ...
The only long-term treatment option for the condition is liver transplantation. While awaiting transplantation, people with HRS ... and all other therapies can best be described as bridges to transplantation. While liver transplantation is by far the best ... The condition is quite common: approximately 10% of individuals admitted to hospital with ascites have HRS. A retrospective ... The diagnosis of hepatorenal syndrome is based on laboratory tests of individuals susceptible to the condition. Two forms of ...
Under natural conditions there are up to 320plants/ha. The seedlings need ample water after planting. A transplantation of the ... Drechsel, Pay; Zech, Wolfgang (1988). "Site conditions and nutrient status of C. edulis (Caesalpiniaceae) in its natural ...
Hematopoietic stem cell transplantation is the only known cure for ZAP70 deficient SCID. ZAP70 deficiency SCID is estimated to ... Children with this condition typically present with infections and skin rashes. Unlike many forms of SCID, absolute lymphocyte ... Fewer than fifty people with this condition have been identified. Online Mendelian Inheritance in Man (OMIM): 176947 Otsu M, ...
Lung transplantation replaces a chronic condition with the ongoing need for treatment.[82] There is a post-surgical median ... Indeed, this condition frequently accompanies severe heart or lung conditions.[11] A 1973 World Health Organization meeting was ... Pulmonary hypertension (PH or PHTN) is a condition of increased blood pressure within the arteries of the lungs.[7] Symptoms ... Associated conditions:connective tissue disease, HIV infection. WHO Group I" - Persistent pulmonary hypertension of the newborn ...
Beta thalassemia major is a severe medical condition. A severe anemia is seen starting at 6 months of age. Without medical ... Beta thalassemia major can be treated by lifelong blood transfusions or bone marrow transplantation. According to a recent ... condition. The homozygous allele has become one of the deadliest genetic factors, whereas people heterozygous for the mutant ...
... and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients ... Dose-reduced conditioning before allogeneic stem cell transplantation: principles, clinical protocols and preliminary results ... The FLAMSA protocol is most often used as an induction part of a reduced-intensity conditioning regimen for patients eligible ... March 2012). "Upfront allogeneic blood stem cell transplantation for patients with high-risk myelodysplastic syndrome or ...
Potential cures include bone marrow transplantation and gene therapy. Congenital dyserythropoietic anemia Thalassemia ... Hemoglobinopathy List of hematologic conditions "Archived copy". Archived from the original on 2012-07-09. Retrieved 2011-09-26 ...
In more severe cases, a partial or complete corneal transplantation may be considered. However, it is common for the dystrophy ... Reis-Bücklers corneal dystrophy is not associated with any systemic conditions. The dystrophy was described in 1917 by Reis and ...
Liver transplantation has proven to be effective for ATTR familial amyloidosis due to Val30Met mutation. In 2011 the European ... Fibrinogen, apolipoprotein A1, and lysozyme are associated with a closely related condition, familial visceral amyloidosis. ... July 2006). "Impact of liver transplantation on cardiac autonomic denervation in familial amyloid polyneuropathy". Medicine ( ... Medicines Agency approved tafamidis for this condition. The FDA rejected the application for marketing approval in the US in ...
The status of this condition as a GSD has been disputed. Making a diagnosis for a genetic or rare disease can often be ... Cardiac transplantation has been performed as a treatment, however most patients die early in life. Danon disease was ... The following resources provide information relating to diagnosis and testing for this condition. If you have questions about ... Orphanet lists international laboratories offering diagnostic testing for this condition. RP-A501 is an AAV-based gene therapy ...
Potential cures include bone marrow transplantation and gene therapy. Congenital dyserythropoietic anemia Thalassemia ... Hemoglobinopathy List of hematologic conditions Fukuda MN (1999). "HEMPAS. Hereditary erythroblastic multinuclearity with ...
Stem cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplantation is a widely ... Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation In National Cancer Institute Fact Sheet web site. ... This type of medicine would allow for autologous transplantation, thus removing the risk of organ transplant rejection by the ... A recurring sub-theme of cloning fiction is the use of clones as a supply of organs for transplantation. Robin Cook's 1997 ...
"Rajinikanth's Condition Stable: Hospital". NDTV. Archived from the original on 10 February 2014. Retrieved 1 July 2011. "Modi ... It was widely reported that he required a kidney transplantation, which was later denied by Dhanush. On 21 May 2011, Aishwarya ... The hospital maintained that Rajinikanth was in stable condition and showed positive response to treatment. ... Rajinikanth took the case of campaigning in support of corneal transplantation via television and public speeches. In 2011, ...
... is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the ... For patients with scalp disease, hair transplantation can help with their hair loss. Discoid lupus erythematosus is a chronic ... The musician Seal has this skin condition. Singer Michael Jackson was reportedly diagnosed with discoid lupus in 1984; the ... Lupus erythematosus List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer List of people with ...
C. R. Fleming, E. R. Dickson, E. G. Harrison, Jr: Splenosis: auto-transplantation of splenic tissue. Widmann, MAJ Warren D. ( ... Multiple implants of splenic tissue can mimic the appearance of some cancerous conditions. This can be clarified through ... Widmann, MAJ Warren D. (1971-02-01). "Splenosis: A Disease or a Beneficial Condition?". Archives of Surgery. 102 (2): 152-8. ... 1971-02-01). "Splenosis: A Disease or a Beneficial Condition?". Archives of Surgery. 102 (2): 152-8. doi:10.1001/archsurg. ...
This latter condition may be fatal in the absence of bone marrow transplantation. Persons with type 3 have the typical light ...
Allogeneic stem cell transplantation can induce durable remissions for heavily pre-treated patients. As of October 2010, there ... Ibrutinib is another agent that has been approved for use in this condition. Combination treatment with Ibrutinib and Rituximab ... Yang L, Wen B, Li H, Yang M, Jin Y, Yang S, Tao J (1999). "Autologous peripheral blood stem cell transplantation for ... Recently, autologous bone marrow transplantation has been added to the available treatment options. When primary or secondary ...
Hair transplantation is a surgical technique that moves individual hair follicles from a part of the body called the donor site ... In this condition, grafts containing hair follicles that are genetically resistant to balding are transplanted to bald scalp. ... Hair transplantation differs from skin grafting in that grafts contain almost all of the epidermis and dermis surrounding the ... Rose, P. (2011). "The Latest Innovations in Hair Transplantation". Facial Plastic Surgery. 27 (4): 366-377. doi:10.1055/s-0031- ...
He was a major contributor to the advancement of liver transplantation. Scharschmidt was born in East Cleveland, Ohio. He now ... "Liver Transplant - Conditions & Treatments - UCSF Medical Center". www.ucsfhealth.org. "Training and Workforce Committee - ... The NIH Consensus Conference concluded that liver transplantation was no longer experimental, which paved the way for its ... Scharschmidt was an invited speaker at the 1982 NIH Consensus conference on Liver Transplantation, he reviewed and presented ...
Although this condition is also known as "denture sore mouth", there is rarely any pain. Candida is associated with about 90% ... organ transplantation and use of indwelling catheters). Oral candidiasis has been recognized throughout recorded history. The ... These conditions all favor the growth of C. albicans. Sometimes dentures become very worn, or they have been constructed to ... This condition can develop into necrotizing ulcerative periodontitis. This is an uncommon form of chronic (more than one month ...
For example, evidence on the effectiveness of acupuncture is "variable and inconsistent" for any condition,[2] but is generally ... Emergency medicine is concerned with the diagnosis and treatment of acute or life-threatening conditions, including trauma, ... Conservation medicine studies the relationship between human and animal health, and environmental conditions. Also known as ... Laser medicine involves the use of lasers in the diagnostics or treatment of various conditions. ...
The first use of X-rays under clinical conditions was by John Hall-Edwards in Birmingham, England on 11 January 1896, when he ...
Today, bone marrow transplantation still offers the only cure for sickle cell disease. Members of Kappa Alpha Psi reach out to ... Jude treats infants, children, teens, and young adults up to age 21 and for some conditions, up to age 25.[3] ... Jude treats infants, children, teens, and young adults up to age 21 and for some conditions, age 25.[3] ... Jude is the first known hospital in the world to cure sickle cell disease through bone marrow transplantation. ...
Most kidney conditions are chronic conditions and so long term followup with a nephrologist is usually necessary. ... Renal transplantation replaces kidney function by inserting into the body a healthier kidney from an organ donor and inducing ... Examples include acquired conditions such as systemic vasculitides (e.g. ANCA vasculitis) and autoimmune diseases (e.g., lupus ... Newer, so-called "biologic drugs" or monoclonal antibodies, are also used in these conditions and include rituximab, ...
"Restless Legs Syndrome Linked To Psychiatric Conditions". http://www.sciencedaily.com/releases/2005/10/051031132243.htm. ... Nephrology Dialysis Transplantation 21: 184-90. doi:10.1093/ndt/gfi144. ...
... by assisting intersexual people to meet and associate with others of like condition. Diamond considered the intersex condition ... Fageeh, W.; Raffa, H.; Jabbad, H.; Marzouki, A. (2002). "Transplantation of the human uterus". International Journal of ... Other health conditions such as diabetes, abnormal blood clotting, ostomies, and obesity do not usually present a problem to ... The conditions do increase the anesthetic risk and the rate of post-operative complications. Surgeons may require overweight ...
Teledermatology can reduce wait times by allowing dermatologists to treat minor conditions online while serious conditions ... Hair transplantation - a cosmetic procedure practiced by many dermatologists.. *Intralesional treatment - with steroid or ... "The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions". IHME. 1 November 2013 ... "Online Visits With Dermatologists Enhance Access to Care for Patients With Minor and Serious Skin Conditions, Boost Physician ...
Preformed vitamin A absorption and storage in the liver occur very efficiently until a pathologic condition develops.[20] When ... Liver transplantation may be a valid option if no improvement occurs.[33] ... Absorption and storage in the liver of preformed vitamin A occur very efficiently until a pathologic condition develops.[20] ... The range of serum retinol concentrations under normal conditions is 1-3 μmol/l. Elevated amounts of retinyl ester (i.e., , 10 ...
... sometimes resulting in kidney failure that has required kidney dialysis or kidney transplantation. In addition, some patients ... Low pH (acidic conditions). *Menthol (mint). *N-Arachidonoyl dopamine. *N-Oleoyldopamine. *N-Oleoylethanolamide ...
Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably ... "Autologous chondrocyte transplantation in the treatment of articular cartilage lesions of the talus". Orthopade (in German). ... or autologous chondrocyte transplantation (ACT). A review evaluating autologous chondrocyte implantation was published in 2010 ... called matrix-associated autologous chondrocyte transplantation (MACT), grows the patient's cells in a 3D matrix of resorbable ...
Forced expiratory volume (time): a generic term indicating the volume of air exhaled under forced conditions in the first t ... Lung transplantation. Decortication of lung. Heart-lung transplant. Chest wall, pleura,. mediastinum,. and diaphragm. pleura/ ... Forced expiratory maneuvers may aggravate some medical conditions.[6] Spirometry should not be performed when the individual ... Spirometry is helpful in assessing breathing patterns that identify conditions such as asthma, pulmonary fibrosis, cystic ...
Conditions for entry include recognized artistic achievement in writing, music, painting, sculpture or cinema as evidenced by ... platelet activation in vascular disease and stem cell transplantation in cancer patients. As an endocrinologist he has an ... HLA-B27-related rheumatologic conditions and screening, transplant cross-matching and graph rejection, pathophysiology of ...
The disadvantage of liver transplantation is that approximately 10% of the subjects die from the procedure or complications ... Skin conditions resulting from errors in metabolism. Hidden categories: *CS1: long volume value ... FAP can be ameliorated by liver transplantation. ...
COPD often occurs along with a number of other conditions, due in part to shared risk factors.[2] These conditions include ... Stopping smoking, respiratory rehabilitation, lung transplantation[2]. Medication. Vaccinations, inhaled bronchodilators and ... A chest X-ray and complete blood count may be useful to exclude other conditions at the time of diagnosis.[80] Characteristic ... The more familiar terms of "chronic bronchitis" and "emphysema" have often been used as labels for this condition.. ...
Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation In National Cancer Institute Fact Sheet web site. ... Without optimal culture conditions or genetic manipulation,[10] Izmantojot cilvēka embrionālās cilmes šūnas laboratorijas ... PMID 17076602. Bone marrow transplantation is, as of 2009, the only established use of stem cells. ... 2015. Bone marrow transplantation is, as of 2009, the only established use of stem cells. ...
In certain conditions, either the number of phagocytes is reduced or their functional capacity is impaired. Severe Congenital ... Virus-specific T-Lymphocytes (VST) therapy is used for patients who have received hematopoietic stem cell transplantation that ... Many of these conditions are associated with skin problems. Hypohidrotic ectodermal dysplasia NEMO deficiency IKBA deficiency ... There are currently no cures for these conditions; treatment is palliative and consists of managing infections and boosting the ...
For a long time, the most efficient approach had been to use bone marrow graft, or hematopoietic stem cell transplantation. ... in hopes of preventing the cognitive decline associated with the severe form of the condition. Results were reported in October ... Because of all these reasons, bone marrow grafts or hematopoietic stem cell transplantation have seen a decrease in their ... long term follow-up on patients undergone to hematopoietic stem cell transplantation, Minerva Pediatr. 2013 Oct;65(5):487-96. ...
... of women with intersex conditions is controversial when it takes place during childhood or under duress. ... Other factors that will affect the technique selected are age, other existing medical conditions, and obesity. Other ... subjected to gonadectomies and partial clitoridectomies after testosterone testing revealed that they had an intersex condition ...
Iradj Gandjbakhch (b. 1941), cardiac surgeon, performed Europe's first heart transplantation on 27 April 1968 along with Dr. ... it provided wretched living conditions for its inmates.[3] The building was enlarged in 1684. ... Christian Cabrol (1925-2017), cardiac surgeon, performed Europe's first heart transplantation on 27 April 1968. ...
In rare cases, intersex conditions can be caused by mosaicism where some cells in the body have XX and others XY chromosomes ( ... The earliest examples of this involved transplantation experiments (technically creating chimeras) where cells from a blastula ...
For the condition in animals, see Corneal ulcers in animals.. This article needs additional citations for verification. Please ... In case of progressive or non-healing ulcers, surgical intervention by an ophthalmologist with corneal transplantation may be ... Other eye conditions can cause corneal ulcers, such as entropion, distichiasis, corneal dystrophy, and keratoconjunctivitis ... Corneal ulcer is an inflammatory or more seriously, infective condition of the cornea involving disruption of its epithelial ...
Tendon xanthomas are seen in 20-40% of individuals with FH and are pathognomonic for the condition.[7] A xanthelasma or corneal ... April 2000). "Liver transplantation in patients with homozygotic familial hypercholesterolemia previously treated by end-to- ... The latter condition can also involve neurological or psychiatric manifestations, cataracts, diarrhea and skeletal ... Sitosterolemia and cerebrotendineous xanthomatosis are two rare conditions that can also present with premature atherosclerosis ...
They do not cover generalist consultations, pre-existing conditions, medical emergencies, organ transplants, chronic conditions ... It has contributed to the development of liver transplantation, being the first in the world to carry out an adult to adult ... Insurers are required to offer insurance to everyone, regardless of age or medical condition. They are not allowed to make a ... It is illegal in The Netherlands for insurers to refuse an application for health insurance, to impose special conditions (e.g ...
Some also use the term motor neuron disease for a group of conditions of which ALS is the most common.[2] ALS is characterized ... "Intraspinal stem cell transplantation for amyotrophic lateral sclerosis". Annals of Neurology. 79 (3): 342-53. doi:10.1002/ana ... A number of biomarkers are being studied for the condition, but so far are not in general medical use.[80][81] ... videos of the Ice Bucket Challenge went viral on the Internet and increased public awareness of the condition.[24] ...
"Nephrology Dialysis Transplantation. 17 (6): 1014-1018. doi:10.1093/ndt/17.6.1014. ISSN 0931-0509. PMID 12032190.. ... approximately 40 percent of those born with this condition have a mutation in the EYA1 gene).[3][5] Many different ...
Surgical resection, chemotherapy, radiation therapy, stenting procedures, liver transplantation[1]. Prognosis. Generally poor[5 ... Dayton MT, Longmire WP, Tompkins RK (January 1983). "Caroli's Disease: a premalignant condition?". American Journal of Surgery ... Adjuvant therapy followed by liver transplantation may have a role in treatment of certain unresectable cases.[70] ... In certain cases surgery may include a liver transplantation.[3] Even when surgery is successful 5-year survival is typically ...
As a condition of full membership, medical practitioners must be ACOG-certified in the reproductive endocrinology and ...
Trichostatin A is also a class I and II HDACi that rescues fear learning in a fear conditioning paradigm in transgenic AD mice ...
Non-Myeloablative Conditioning and Bone Marrow Transplantation. The safety and scientific validity of this study is the ... Experimental: Non-Myeloablative Conditioning and Bone Marrow Transplantation Drug: Thymoglobulin Day 9 - 0.5 mg/kg IV before ... A Non-Myeloablative Conditioning and Transplantation of Partially HLA-Mismatched and HLA-Matched Bone Marrow for Patients With ... Procedure: Bone marrow transplantation Day 0 - Transplantation of hematopoietic cells derived from bone marrow of a donor to a ...
Fludarabine is the most frequently used agent in conditioning regimens for allogeneic hematopoietic cell transplantation (HCT ... Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes.. Langenhorst ... Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes ... Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes ...
Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation. The safety and scientific validity of this study ... Condition or disease Intervention/treatment Phase Bone Marrow Failure Syndrome Thalassemia Sickle Cell Disease Diamond Blackfan ... Hematopoietic stem cell transplantation is the only curative choice for a number of inherited bone marrow failure syndromes, ... Conditioning regimen for hematopoietic stem-cell transplant. Single daily IV dose of Thiotepa at 5 mg/kg. ...
... in patients with hematologic malignancies receiving a reduced intensity conditioning (RIC) regimen. A total of 152 patients ... This retrospective report compared the results of graft source on outcome after allogeneic stem cell transplantation (allo-SCT ... Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with ... Reduced-intensity conditioning transplantation in acute leukemia: the effect of source of unrelated donor stem cells on ...
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Sequential Trial on Reduced Intensity Conditioning (RIC) Allogeneic Transplantation (EMN-alloRIC). The safety and scientific ...
... transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy. ... Immune Response in the Liver under Conditions of Infection, Malignancy, and Transplantation. Guest Editors: Basak Kayhan, Sukru ... Immune Response in the Liver under Conditions of Infection, Malignancy, and Transplantation, Basak Kayhan, Sukru Oguz Ozdamar, ... Immune Response following Liver Transplantation Compared to Kidney Transplantation: Usefulness of Monitoring Peripheral Blood ...
... in Shenzhen using Beikes proprietary cord blood stem cell transplantation protocol. ... Study demonstrates safety of cord blood stem cell transplantation protocol to treat neurological conditions. *Download PDF Copy ... Posted in: Medical Procedure News , Medical Science News , Medical Condition News. Tags: Biotechnology, Blood, Bone, Bone ... News-Medical.Net provides this medical information service in accordance with these terms and conditions. Please note that ...
New conditioning regimens are still needed to maximize efficacy and limit treatment-related deaths of allogeneic ... Fludarabine Based Conditioning for Allogeneic Transplantation for Advanced Hematologic Malignancies. Trial Phase:. N/A. Minimum ... Fludarabine Based Conditioning for Allogeneic Transplantation for Advanced Hematologic Malignancies. Treatment-related ... failures in allogeneic transplantation for advanced hematologic malignancies. The most. commonly utilized conditioning regimens ...
... and other conditions, possibly including AIDS. Autologous HSCT using genetically corrected cells would avoid the risk of graft- ... Hematopoietic stem cell transplantation (HSCT) offers curative therapy for patients with hemoglobinopathies, congenital ... Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing ... This non-genotoxic conditioning method may provide an attractive alternative to current conditioning regimens for HSCT in the ...
Allogeneic transplantation is a procedure in which a person receives hematopoietic (blood-forming) or blood stem cells, from a ... About Allogeneic Transplantation. * What is allogeneic transplantation? Blood and marrow transplantation is a special therapy ... Allogeneic bone marrow transplantation is the only curative therapy available for patients with these conditions. ... Preparing for transplantation for a child *Medical history and physical evaluation: Up to 21 days before transplantation, the ...
BEB Conditioning Regimen for Autologous Stem-cell Transplantation(ASCT) in Non-Hodgkins Lymphoma. 2016-07-20 02:38:22 , ... Home » Topics » Clincial Trials » Research » BEB Conditioning Regimen for Autologous Stem-cell Transplantation(ASCT) in Non- ... More From BioPortfolio on "BEB Conditioning Regimen for Autologous Stem-cell Transplantation(ASCT) in Non-Hodgkins Lymphoma". ... Conditioning Regimen for Autologous Stem Cell Transplantation in Lymphoma. ...
We report our experience in 4 patients with AML who received 16 Gy TBI prior to allogeneic hematopoietic cell transplantation ( ... as the standard conditioning before transplantation [14].. Attempts at reducing the morbidity and mortality of the conditioning ... B. Gyurkocza and B. M. Sandmaier, "Conditioning regimens for hematopoietic cell transplantation: one size does not fit all," ... A. S. Schulz, G. Glatting, M. Hoenig et al., "Radioimmunotherapy-based conditioning for hematopoietic cell transplantation in ...
Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia (SAA) ... cyclophosphamide plus thymoglobulin conditioning regimen for unrelated donor transplantation in severe aplastic anemia by ... Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia (SAA). * ... Anti-thymocyte globulin (ATG) has been used in severe aplastic anemia as a part of the conditioning regimen. Among the many ...
TBI Conditioning Regimen for Double Units Cord Blood Transplantation(CBT)in Severe Aplastic Anemia(SAA) ... Study of Fludarabine + Cyclophosphamide + TBI Conditioning Regimen for Double Units Cord Blood Transplantation(CBT)in Severe ... TBI conditioning regimen for double units cord blood transplantation was proposed for the patient with severe aplastic anemia ... Cord blood transplantation (CBT) has become an alternative treatment means in various diseases, but it has not been proved to ...
Nonmyeloablative (NMA) conditioning regimens facilitate allogeneic stem cell transplantation (alloSCT) in elderly patients and/ ... as conditioning prior to allogeneic stem cell transplantation in patients Final publishers version, 782 KB, PDF document ... as conditioning prior to allogeneic stem cell transplantation in patients (,= 60 years) with acute myelogenous leukemia: a ... The acute leukemia working party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT) compared the ...
Phase I/II Study of CD45 Antibodies and Alemtuzumab Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation ... Phase I/II Study of CD45 Antibodies and Alemtuzumab Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation ... 2. Conditions that increase Treatment Related Mortality (need one or more to be. eligible):. Greater or equal to 35 years of ... stem cell transplantation:. Acute myeloid leukemia either a) Primary refractory, or b) Beyond first complete. remission(CR1), ...
"Transplantation Conditioning" by people in this website by year, and whether "Transplantation Conditioning" was a major or ... prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation. ... "Transplantation Conditioning" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Transplantation Conditioning" by people in Profiles. ...
The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM ... Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid ... Twenty-seven patients were transplanted, 17 with a myeloablative conditioning regimen and 10 with RIC. ... transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC ...
Condition. Kidney injury after transplantation Intervention. Patients will be randomised to either receive RPC during ... A double-blinded randomised controlled trial of Remote Post-Conditioning in renal transplantation ... Condition category. Urological and Genital Diseases Date applied. 02/08/2011 Date assigned. 19/09/2011 Last edited. 29/01/2018 ... After transplantation participants receive the normal treatment and care associated with receiving a kidney transplant and the ...
Allogeneic Hematopoietic Cell Transplantation for Metastatic Renal Cell Carcinoma after Nonmyeloablative Conditioning. Toxicity ... Hentschke P, Barkholt L, Uzunel M, et al Low-intensity conditioning and hematopoietic stem cell transplantation in patients ... Allogeneic Hematopoietic Cell Transplantation for Metastatic Renal Cell Carcinoma after Nonmyeloablative Conditioning ... Allogeneic Hematopoietic Cell Transplantation for Metastatic Renal Cell Carcinoma after Nonmyeloablative Conditioning ...
Hematopoietic stem cell transplantation may be used to treat a number of conditions both congenital and acquired. Malignancies ... "Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation". N Engl J Med. 360 (7): 692-698. doi:10.1056/ ... "Conditions stem cell transplant can cure". INDHEAL.. ...
Conclusion Conditioning regimens cause tissue damage in the skin, but this does not result in a local increase of activated APC ... Thus, the local skin damage caused by the conditioning regimen appears to be insufficient as single factor to provoke GVHD ... Results No inflammatory environment due to pretransplant conditioning was detected at the time of alloSCT, irrespective of the ... irrespective of the conditioning regimen. An increase in HLA class II-positive macrophages and CD3 T-cells was observed 12-24 ...
Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for ... Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for ... Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for ... Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for ...
Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with ... Standard myeloablative conditioning prior to allogeneic hematopoietic stem cell (HSC) transplantation has been associated with ... Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with ... Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with ...
Comparison of conditioning regimens for autologous stem cell transplantation in children with acute myeloid leukemia: A ... The transplantation outcomes of various conditioning regimens were compared. RESULTS: The median follow-up period of the ... Comparison of conditioning regimens for autologous stem cell transplantation in children with acute myeloid leukemia: A ... "Comparison of Conditioning Regimens for Autologous Stem Cell Transplantation in Children With Acute Myeloid Leukemia: a ...
An Analysis on Behalf of the Pediatric Disease Working Party of the European Group for Blood and Marrow Transplantation. ... Impact of Conditioning Regimen on Outcomes for Children with Acute Myeloid Leukemia Undergoing Transplantation in First ... Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, 23(3), 467- ... Impact of Conditioning Regimen on Outcomes for Children with Acute Myeloid Leukemia Undergoing Transplantation in First ...
High-dose therapy with BEAC conditioning compared to BEAM conditioning prior to autologous stem cell transplantation for non- ... Study of BuEAM Conditioning for Autologous Stem Cell Transplantation (ASCT) to Treat Diffuse Large B Cell Lymphoma (DLCBL). ... transplantation in patients with NHL.. Description. Among the high-dose conditioning regimens commonly used in patients with ... nThe Effect of Conditioning Regimen Dose Reduction in Obese Patients Undergoing Autologous Hematopoietic Cell Transplantation. ...
Transplantation of non-vital anatomic body parts has also been accomplished. Hand transplantation after limb loss in adults has ... Transplants for non-lethal conditions: a case against hand transplantation in minors ... Transplants for non-lethal conditions: a case against hand transplantation in minors ... Uterus transplantation: ethical and regulatory challenges. Kavita Shah Arora et al., Journal of Medical Ethics, 2013 ...
Allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning in acute lymphoblastic leukemia: a ... Allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning in acute lymphoblastic leukemia: a ... This retrospective study suggests that allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning ... DESIGN AND METHODS: We report the results of a reduced intensity conditioning regimen followed by allogeneic hematopoietic stem ...
  • The most commonly utilized conditioning regimens consist of cyclophosphamide and total-body irradiation or busulfan and cyclophosphamide. (knowcancer.com)
  • As the fludarabine based conditioning regimens without total body irradiation have been reported to be promising for transplantation from alternative donors in SAA, thymoglobulin was added to fludarabine and cyclophosphamide conditioning to reduce GVHD and to allow good engraftment in unrelated donor transplantation. (centerwatch.com)
  • 60 years with AML in first complete remission (CR1), that had received an alloSCT following NMA conditioning, i.e. either fludarabine/busulfan (FB2) or fludarabine/total-body-irradiation-2Gy (FluTBI2Gy). (rug.nl)
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
  • Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
  • Results of Haploidentical Stem Cell Transplantation after a Conditioning Regimen without Total Body Irradiation in Elderly Patients with Advanced Myeloid and Lymphoid Malignancies. (aspergillus.org.uk)
  • Experience with haploidentical stem cell transplantation in elderly patients after non TBI (total body irradiation) containing regimens is limited. (aspergillus.org.uk)
  • Does total body irradiation conditioning improve outcomes of myeloablative human leukocyte antigen-identical sibling transplantations for chronic lymphocytic leukemia? (elsevier.com)
  • Because CLL is a highly radiosensitive cancer, we hypothesized that total body irradiation (TBI) conditioning regimens may be associated with better outcomes than those without TBI. (elsevier.com)
  • We identified myeloablative conditioning and conditioning with high-dose total body irradiation (10-12 Gy) as risk factors for T. gondii reactivation, whereas patients with a seropositive donor were less likely to experience reactivation. (blogspot.com)
  • The 3.9 × 10 7 /kg CB cells from an HLA one-locus mismatched unrelated donor were infused after conditioning with total body irradiation (5 Gy), melphalan (120 mg/m 2 ), and fludarabin (120 mg/m 2 ). (elsevier.com)
  • Autologous HSCT using genetically corrected cells would avoid the risk of graft-versus-host disease (GVHD), but the genotoxicity of conditioning remains a substantial barrier to the development of this approach. (nih.gov)
  • Conditioning regimens preceding allogeneic stem cell transplantation (alloSCT) can cause tissue damage and acceleration of the development of graft-versus-host disease (GVHD). (frontiersin.org)
  • After allogeneic stem cell transplantation (alloSCT), severe graft-versus-host disease (GVHD) can be induced by donor T-cells recognizing normal tissues of the recipient. (frontiersin.org)
  • BACKGROUND: In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. (uzh.ch)
  • In addition, depletion CD3±CD19 cells may contribute to prevent developing severe acute graft versus host disease (GVHD) in haploidentical transplantation. (ichgcp.net)
  • 1 , 2 Since that time, despite uneven progress and problems with entities such as graft-versus-host disease (GVHD), 3 , 4 the procedure has become an accepted treatment for various hematologic deficiencies and malignant conditions. (cmaj.ca)
  • Preliminary results of non-myeloablative allogeneic stem cell transplantation suggest that the procedure can be performed in patients who are ineligible for myeloablative alloBMT, and that sustained remissions of several hematologic malignancies can be obtained. (clinicaltrials.gov)
  • Standard myeloablative conditioning prior to allogeneic hematopoietic stem cell (HSC) transplantation has been associated with significant toxicity in patients older than 45 years of age with myelofibrosis with myeloid metaplasia (MMM). (bloodjournal.org)
  • 10 Although selected older patients may fare well with standard myeloablative conditioning, 11 such data raise concern that this conventional approach may be too toxic for the majority of patients with MMM owing to their advanced age. (bloodjournal.org)
  • We conducted reevaluation of autologous HSCT (AHSCT) to compare myeloablative conditioning (MAC) regimens for pediatric AML without the need for consideration of toxicities caused by allogeneic immune reactions. (unboundmedicine.com)
  • INTERPRETATION AND CONCLUSIONS: This retrospective study suggests that allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning might be a useful therapeutic option for some patients with ALL who are ineligible for standard myeloablative conditioning. (haematologica.org)
  • Herein we discuss the studies that demonstrate the feasibility of reduced intensity conditioning allogeneic transplants, compare the outcomes of reduced intensity conditioning versus chemotherapy and conventional myeloablative conditioning regimens, describe the optimal donor and stem cell source, and consider the impact of post-remission consolidation, comorbidities, center experience, and more intensive (reduced toxicity conditioning) regimens on outcomes. (haematologica.org)
  • Background: Increasing numbers of patients are receiving haplo-identical stem cell transplantation (haplo-SCT) for treatment of acute leukemia with reduced intensity (RIC) or myeloablative (MAC) conditioning regimens. (uni-muenchen.de)
  • For these chemoresistant, multiply relapsed patients, allogeneic SCT employing conventional myeloablative conditioning has generally had poor results,7-11 with prohibitive transplant-related mortality (TRM) and high relapse rates. (haematologica.org)
  • Reduced-intensity conditioning (RIC) prior to allogeneic SCT has been proposed as a means to achieve engraftment and induce graft-versus-malignancy effects without the morbidity and mortality associated with myeloablative conditioning regimens.15 This approach has recently been employed in patients with relapsed and refractory HL.14,16-19 Such patients seem well suited for this approach. (haematologica.org)
  • Despite their young age, they are heavily pre-treated and tolerate conventional myeloablative conditioning poorly. (haematologica.org)
  • Akahori M, Nakamae H, Hino M, Yamane T, Hayashi T, Ohta K, Tatsumi N, Kitagawa S, Tsumura K (2003) Electrocardiogram is very useful for predicting acute heart failure following myeloablative chemotherapy with hematopoietic stem cell transplantation rescue. (springer.com)
  • RT7(b) expressing, BM- seeded alpha/beta TCR+ cells seem to impair the engraftment process after myeloablative mAb conditioning. (uni-regensburg.de)
  • Myeloablative conditioning (MAC) and reduced-intensity conditioning (RIC) regimens could have different clinical outcomes. (tjh.com.tr)
  • An allogeneic hematopoietic cell transplantation from an HLA-identical donor after high-dose (myeloablative) pretransplantation conditioning is an effective therapy for some people with chronic lymphocytic leukemia (CLL). (elsevier.com)
  • Within the limitations of this study, we found no difference in HLA-identical sibling transplantation outcomes between myeloablative TBI and chemotherapy pretransplantation conditioning in persons with CLL. (elsevier.com)
  • Intensified conditioning regimens (increasing the intensity of standard myeloablative conditioning) for hematological malignancies in allogeneic hematopoietic stem cell transplantation (allo-HSCT) could reduce the relapse rate of the underlying disease, but it might simultaneously increase the transplant-related mortality including the mortality of infections. (biomedcentral.com)
  • In this multicenter retrospective study, the outcomes of 836 patients with myelodysplastic syndrome (MDS) who underwent transplantation with a human leukocyte antigen (HLA)-identical sibling donor were analyzed according to 2 types of conditioning: reduced-intensity conditioning (RIC) in 215 patients, and standard myeloablative (or high-dose) conditioning (SMC) in 621 patients. (ru.nl)
  • Recently, umbilical cord blood transplantation (CBT) after non-myeloablative therapy has been reported in adult but not in childhood SAA. (elsevier.com)
  • [email protected]#Modified BU/CY as conditioning regimen for auto-PBHSCT can achieve the myeloablative effect without raising TRM and obtain good LFS and OS. (bvsalud.org)
  • Indications for hematopoietic stem cell transplantation (HSCT) have decreased with the improvement in chemotherapy for pediatric acute myeloid leukemia (AML) in the last decade. (unboundmedicine.com)
  • Impact of Conditioning Regimen on Outcomes for Children with Acute Myeloid Leukemia Undergoing Transplantation in First Complete Remission. (unboundmedicine.com)
  • Hematopoietic stem cell transplantation (HSCT) represents the cornerstone of treatment in pediatric high-risk and relapsed acute myeloid leukemia (AML). (unboundmedicine.com)
  • BACKGROUND AND OBJECTIVES: Numerous studies have reported the feasibility of performing allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning, although results in individual diseases are scarce, with no studies in patients with acute lymphoblastic leukemia (ALL). (haematologica.org)
  • Acute liver failure is a rare condition in which the liver rapidly deteriorates and stops functioning within a matter of days. (columbiasurgery.org)
  • While other liver conditions take months or years to destroy the liver, acute liver failure takes only days. (columbiasurgery.org)
  • Rare conditions such as Wilson's disease can cause acute liver failure. (columbiasurgery.org)
  • Because many of these symptoms can be associated with other conditions, it can be difficult to detect signs of acute liver failure. (columbiasurgery.org)
  • Depending on its cause, there are two forms of treatment for acute liver failure: medication and transplantation. (columbiasurgery.org)
  • In this prospective, open-label randomised phase 3 trial we compared a reduced-intensity fludarabine-based conditioning regimen with a standard regimen in patients with acute myeloid leukaemia in first complete remission. (nih.gov)
  • Reduced-intensity conditioning results in a similar incidence of non-relapse mortality and reduced toxic effects compared with standard conditioning without affecting survival outcomes, and thus could be preferentially used in patients younger than 60 years with acute myeloid leukaemia transplanted in first complete remission. (nih.gov)
  • Reduced intensity conditioning allogeneic transplantation is currently the standard of care for patients with intermediate or high-risk acute myeloid leukemia and is now most often employed in older patients and those with medical comorbidities. (haematologica.org)
  • Allogeneic hematopoietic cell transplantation (HCT) is an established treatment modality that is potentially curative for many patients with acute myeloid leukemia (AML). (haematologica.org)
  • Schmid C, Schleuning M, Ledderose G, Tischer J, Kolb HJ (2005) Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome. (springer.com)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) has not been widely used in patients with acute myeloid leukemia (AML) and Down syndrome (DS) due to fear of transplantation-related toxicity. (elsevier.com)
  • An early stage pharmaceutical company with fast development timelines focused on kidney ischemia-reperfusion injury (IRI), including acute kidney injury and kidney transplantation. (balmestransplantation.com)
  • In humans, such dynamic NK cell responses were been documented primarily in the context of acute or latent infection with CMV ( 7 - 9 ), in particular following allogeneic hematopoietic stem cell transplantation (HSCT) ( 10 - 12 ). (jimmunol.org)
  • The Adult Myelodysplastic Syndrome and Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation 2015, ' Effect of Granulocyte Colony-Stimulating Factor-Combined Conditioning in Cord Blood Transplantation for Myelodysplastic Syndrome and Secondary Acute Myeloid Leukemia: A Retrospective Study in Japan ', Biology of Blood and Marrow Transplantation , 巻. (elsevier.com)
  • Hematopoietic stem cell transplantation (HSCT) is considered an effective way to prevent relapse in adults with acute lymphoblastic leukemia (ALL). (springer.com)
  • As the leader in pediatric care, the Division of Nephrology and Hypertension at Nationwide Children's provides comprehensive acute and chronic nephrology services, urinary tract evaluation, dialysis, kidney transplantation, hypertension diagnostics and management, as well as treatment of metabolic bone disease. (nationwidechildrens.org)
  • The role of hematopoietic stem cell transplantation is reviewed in children and adults with acute lymphoblastic leukemia in the era of novel agents and targeted therapies. (intechopen.com)
  • Various modalities of stem cell therapies in different types of acute lymphoblastic leukemia as well as closely related issues such as graft versus tumor effect, minimal residual disease, and conditioning therapies are discussed thoroughly. (intechopen.com)
  • Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes. (nih.gov)
  • Intensification of the conditioning regimen represents a promising strategy to improve outcomes but has been limited by excessive transplant-related morbidity [ 12 , 13 ]. (hindawi.com)
  • Hematopoietic Cell Transplantation Outcomes in Monosomal Karyotype Myeloid Malignancies. (umassmed.edu)
  • The transplantation outcomes of various conditioning regimens were compared. (unboundmedicine.com)
  • Subgroup analyses showed that patients aged between 40 and 49 years as well as those in first or second CR at the time of transplantation exhibited similar outcomes regardless of whether they were treated with RIC or MAC. (ovid.com)
  • Liver transplantations have been linked with good long-term outcomes for patients with primary biliary cirrhosis. (columbiasurgery.org)
  • We hypothesized that the NRM advantage of reduced-intensity conditioning (RIC) and higher graft-versus-leukemia effect associated with greater HLA disparities would expand its use for patients (aged 40 to 60 years) without compromising efficacy and compared outcomes between RIC and MAC regimens. (eur.nl)
  • Materials and Methods: We retrospectively compared long-term outcomes with MAC and RIC regimens in patients with AML who underwent allo-HSCT at our tertiary transplantation center. (tjh.com.tr)
  • In particular, perfusion characteristics (renal resistance) and perfusate biomarker concentrations (lactate dehydrogenase, aspartate aminotransferase, heart-type fatty acid binding protein, and IL-18) during machine preservation, proved to be reliable tools to rule out graft viability and predict outcomes after transplantation. (omicsonline.org)
  • Our patients may be invited to take part in a study that contributes to the understanding of transplantation immunobiology, clinical outcomes and how to better facilitate successful and safe transplantation in both the short and long term. (imperial.nhs.uk)
  • Hypothermic Machine Perfusion in Kidney Transplantation: Back to the Future? (omicsonline.org)
  • Kidney transplantation is the treatment of choice of end stage renal disease [ 1 ]. (omicsonline.org)
  • Biology of Blood and Marrow Transplantation , 20 (3), 421-424. (elsevier.com)
  • Biology of Blood and Marrow Transplantation , 21 (9), 1632-1640. (elsevier.com)
  • Unrelated umbilical cord blood (UCB) has emerged as an effective stem cell source for allogeneic hematopoietic stem cell transplantation (allo-SCT) in patients who lack a matched related or unrelated donor available. (nature.com)
  • Thus far, no study comparing 9/10-matched unrelated donor and dUCB transplantation have been undertaken. (nature.com)
  • Allogeneic transplantation is a procedure in which a person receives hematopoietic ( 1 ) (blood-forming) or blood stem cells, from a genetically similar, but not identical, donor. (childrensnational.org)
  • reduced toxicity fludarabine, cyclophosphamide plus thymoglobulin conditioning regimen for unrelated donor transplantation in severe aplastic anemia' by reducing dosage of cyclophosphamide and increasing dosage of fludarabine. (centerwatch.com)
  • To increase the engraftment potential, fludarabine, cyclophosphamide plus TBI conditioning regimen for double units cord blood transplantation was proposed for the patient with severe aplastic anemia without HLA-matched donor. (centerwatch.com)
  • Since graft-versus-tumor reactivity is reduced after TCD alloSCT, postponed donor lymphocyte infusions (DLIs) are frequently administered after transplantation to promote antitumor reactivity with a lower risk of GVHD ( 2 , 5 - 7 ). (frontiersin.org)
  • 12-14 On the basis of previous observations, we hypothesized that a reduced-intensity fludarabine-and-melphalan-containing conditioning regimen would promote initial engraftment and establish full-donor chimerism yet result in a lower risk of transplantation-related morbidity in older patients with MMM receiving an HSC transplant from an HLA-identical sibling. (bloodjournal.org)
  • Patients were considered eligible for HSC transplantation with a nonmyeloablative conditioning regimen if they were older than age 45 years, had an HLA-identical sibling donor, and had a diagnosis of MMM based on the criteria proposed by Laszlo. (bloodjournal.org)
  • Reduced intensity conditioning and allogeneic stem cell transplantation in children and adolescents with malignancies from unrelated cord blood and matched family donors results in 92% achieving ≥95% donor chimerism. (aacrjournals.org)
  • In this ASH oral abstract presentation, the investigators sought to shed light on the unanswered question of what is the best conditioning regimen for patients with severe aplastic anemia who are being prepared for bone marrow transplantation with an unrelated donor . (aamds.org)
  • These results support the consideration of the dosing in study 2 with cyclophosphamide (60mg/kg once daily on days -8 and -7), fludarabine (40mg/m2 on days -6,-5,-4,-3,and -2), and thymoglobulin (2.5mg/kg daily on days -4,-3,and -2) as the optimal conditioning regimen for patients with severe aplastic anemia receiving a bone marrow transplant from an unrelated donor. (aamds.org)
  • Design and Methods In this phase II study 92 patients with relapsed Hodgkin's lymphoma and an HLA-identical sibling, a matched unrelated donor or a one antigen mismatched, unrelated donor were treated with salvage chemotherapy followed by reduced intensity allogeneic transplantation. (haematologica.org)
  • Kremens B, Basu O, Grosse-Wilde H, Sauerwein W, Schaefer UW, Havers W. Transplantation of CD34-enriched peripheral stem cells from an HLA-haplotype mismatched donor to a patient with severe aplastic anemia. (ichgcp.net)
  • In 2014, according to the World Marrow Donor Association (WMDA), stem cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone marrow donations, 12,506 peripheral blood stem cell donations, and 3,949 cord blood units). (wikipedia.org)
  • In this study, we addressed whether such CMV-induced imprints on the donor NK cell repertoire influenced the outcome of allogeneic stem cell transplantation. (jimmunol.org)
  • Fecal microbiota transplantation (FMT) is the introduction of a fecal suspension derived from a healthy donor into the gastrointestinal (GI) tract of a diseased individual. (springer.com)
  • Discusses high-dose chemotherapeutic regimens and radiation therapy, patient and donor selection and workup, as well as other key aspects of hematopoietic cell transplantation. (elsevierhealth.com)
  • Allogeneic transplantation represents 40% of all stem cell transplants performed annually in Canada and requires donor and recipient matching for major histocompatibility (HLA) antigens. (cmaj.ca)
  • Blood stem cell transplantation is accomplished by treating the donor with hematopoietic growth factors, which cause the stem cells to proliferate and circulate freely in the peripheral blood. (cmaj.ca)
  • We are also national leaders in liver transplantation, with one of the country's largest living donor liver programs, and offer this approach for people whose liver disease cannot be effectively treated using other methods. (nyp.org)
  • Organ transplantation is a surgical procedure to replace a failing, diseased organ with a healthier donor organ, such as a heart, liver, kidney, or lung. (medindia.net)
  • Corneal transplantation is a surgical procedure to remove damaged cornea and replace it with a healthy cornea from a deceased donor. (medindia.net)
  • Hematopoietic stem cell transplantation (HSCT) offers curative therapy for patients with hemoglobinopathies, congenital immunodeficiencies, and other conditions, possibly including AIDS. (nih.gov)
  • This non-genotoxic conditioning method may provide an attractive alternative to current conditioning regimens for HSCT in the treatment of non-malignant blood diseases. (nih.gov)
  • 18 years age undergoing matched allogeneic HSCT for AML in first complete remission (CR1) in 204 European Group for Blood and Marrow Transplantation centers between 2000 and 2010 were analyzed. (unboundmedicine.com)
  • Among pediatric patients receiving HSCT for AML in CR1, the use of BuCyMel conditioning proved superior to TBICy and BuCy in reducing relapse and improving LFS. (unboundmedicine.com)
  • Objective: Allogeneic hematopoietic stem cell transplantation (HSCT) is an effective treatment modality for a variety of malignant and non-malignant hematologic disorders. (tjh.com.tr)
  • Hematopoietic stem cell transplantation (HSCT) for autoimmune diseases have been, because of safety reasons, overwhelmingly autologous. (northwestern.edu)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) with reduced-intensity conditioning (RIC) offers a potential cure for patients with myelodysplastic syndrome (MDS) who are ineligible for standard-intensity regimens. (kcl.ac.uk)
  • Hematopoietic stem cell transplantation ( HSCT ) is the transplantation of multipotent hematopoietic stem cells , usually derived from bone marrow, peripheral blood, or umbilical cord blood. (wikipedia.org)
  • To explore whether intensified conditioning affected Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections, 185 patients undergoing allo-HSCT were enrolled. (biomedcentral.com)
  • Hematopoietic stem cell transplantation (HSCT) is a procedure in which stem cells are derived from the bone marrow or the umbilical cord. (steadyhealth.com)
  • The recovery of T-cell receptor excision circles (TRECs) was slow, but became detectable 1 year post-hematopoietic stem cell transplantation (HSCT). (biomedcentral.com)
  • [email protected]#Ten young AML patients of low and middle risk who did not want to accept allogeneic hematopoietic stem cell transplantation(allo-HSCT)and underwent auto-PBHSCT in CR1 during May 2013 to December 2016 were retrospectively analyzed. (bvsalud.org)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) is considered an effective way to prevent relapse. (springer.com)
  • Reactivation of latent viruses such as human cytomegalovirus (HCMV) after allogeneic hematopoietic stem cell transplantation (HSCT) results in high morbidity and mortality. (biomedcentral.com)
  • Fludarabine is the most frequently used agent in conditioning regimens for allogeneic hematopoietic cell transplantation (HCT). (nih.gov)
  • In this study, the investigators test 2 dose levels of thiotepa (5 mg/kg and 10 mg/kg) added to the backbone of targeted reduced dose IV busulfan, fludarabine and rabbit anti-thymocyte globulin (rATG) to determine the minimum effective dose required for reliable engraftment for subjects undergoing hematopoietic stem cell transplantation for non-malignant disease. (clinicaltrials.gov)
  • Over the past several years, the investigators have evaluated several new conditioning regimens that incorporate fludarabine, a novel immunosuppressant that has limited toxicity and that has synergistic activity with alkylating agents. (knowcancer.com)
  • (13) reported the results of 19 patients with progressive metastatic renal cell carcinoma treated with cyclophosphamide and fludarabine followed by allogeneic hematopoietic cell transplantation and posttransplant immunosuppression with cyclosporine. (aacrjournals.org)
  • Sixteen patients with adult T-cell leukemia/lymphoma (ATL) who were all over 50 years of age underwent allogeneic stem cell transplantation with reduced-conditioning intensity (RIST) from HLA-matched sibling donors after a conditioning regimen consisting of fludarabine (180 mg/m 2 ), busulfan (8 mg/kg), and rabbit antithymocyte globulin (5 mg/kg). (bloodjournal.org)
  • Fludarabine (150 mg/m 2 iv) and melphalan (140 mg/m 2 iv) were used as the conditioning regimen. (haematologica.org)
  • All patients were prepared with a conditioning regimen consisting of Thiotepa 2 x 5 mg/kg on day 8, ATG Fresenius 5 mg/kg on days 7 to 3, Fludarabine 40 mg/m2 on days 7 to 3, Melphalan 100140 mg/m2 on days 2. (aspergillus.org.uk)
  • Rationale: Chemotherapy with fludarabine, cyclophosphamide and anti-thymocyte globulin may induce the engraftment cross the immunologic barrier in the setting of HLA-haploidentical allogeneic hematopoietic cell transplantation. (ichgcp.net)
  • To assess the engraftment rate and survival of CD3±CD19 depleted haploidentical peripheral blood stem cell transplantation after conditioning with fludarabine, cyclophosphamide and anti-thymocyte globulin. (ichgcp.net)
  • Haploidentical haematopoietic stem cell transplantation using CD3 or CD3/CD19 depletion and conditioning with fludarabine, cyclophosphamide and antithymocyte globulin for acquired severe aplastic anaemia. (ichgcp.net)
  • To evaluate the engraftment potential of fludarabine, busulfan plus thymoglobulin conditioning regimen for cord blood transplantation (CBT) in severe aplastic anemia. (ichgcp.net)
  • Lankester A Pediatrics Department, Division of Immuno-Hematology and Stem Cell Transplantation Leiden University Hospital, The Netherlands. (unboundmedicine.com)
  • Hematopoietic stem cell transplantation is the only curative choice for a number of inherited bone marrow failure syndromes, hemoglobinopathies, metabolic disorders and primary immune deficiencies. (clinicaltrials.gov)
  • This retrospective report compared the results of graft source on outcome after allogeneic stem cell transplantation (allo-SCT) in patients with hematologic malignancies receiving a reduced intensity conditioning (RIC) regimen. (nature.com)
  • http://www.medisteminc.com ), reported positive safety data in 114 patients who were treated by doctors at Nanshan Affiliated Hospital of Guangdong Medical College (Shenzhen Nanshan Hospital) in Shenzhen using Beike's proprietary cord blood stem cell transplantation protocol. (news-medical.net)
  • In order to improve the clinical result of high-dose chemotherapy and autologous stem cell transplantation for B-cell non-Hodgkin's lymphoma, Zevalin will be added to the conditioning regi. (bioportfolio.com)
  • High-dose chemotherapy and autologous stem cell transplantation (ASCT) is the current standard of care for relapsed non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). (bioportfolio.com)
  • Hematopoietic stem cell transplantation may be used to treat a number of conditions both congenital and acquired. (wikipedia.org)
  • We report our experience in 4 patients with AML who received 16 Gy TBI prior to allogeneic hematopoietic cell transplantation (alloHCT), between June 2010 and May 2011. (hindawi.com)
  • However, long-term remission may be achieved more frequently with an allogeneic hematopoietic cell transplantation (alloHCT), approaching an overall survival of 20-30% beyond 2 years [ 1 - 9 ]. (hindawi.com)
  • Nonmyeloablative (NMA) conditioning regimens facilitate allogeneic stem cell transplantation (alloSCT) in elderly patients and/or in those with comorbidities. (rug.nl)
  • This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
  • Such antigens may represent therapeutic targets for posttransplant vaccination or adoptive T-cell therapy to augment the antitumor effects of allogeneic hematopoietic cell transplantation. (aacrjournals.org)
  • A subset of solid tumors including renal cell carcinoma also respond to the graft- versus -tumor effect of reduced intensity allogeneic hematopoietic cell transplantation. (aacrjournals.org)
  • 1 - 5 However, there have been a few encouraging reports on allogeneic stem cell transplantation (alloSCT) for selected populations of patients with ATL. (bloodjournal.org)
  • Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan. (unboundmedicine.com)
  • High-dose therapy with BEAC conditioning compared to BEAM conditioning prior to autologous stem cell transplantation for non-Hodgkin lymphoma: no differences in toxicity or outcome. (bioportfolio.com)
  • nThe Effect of Conditioning Regimen Dose Reduction in Obese Patients Undergoing Autologous Hematopoietic Cell Transplantation. (bioportfolio.com)
  • DESIGN AND METHODS: We report the results of a reduced intensity conditioning regimen followed by allogeneic hematopoietic stem cell transplantation in 27 adult patients with high-risk ALL who were included in four prospective studies. (haematologica.org)
  • Clinical efficacy of allogeneic hematopoietic cell transplantation (HCT) using reduced-intensity conditioning (RIC) for younger patients remains unclear. (ovid.com)
  • We matched 34 pairs of patients with regard to disease status at the time of autologous stem cell transplantation (auto-SCT). (springer.com)
  • Colpo A, Hochberg E, Chen YB (2012) Current status of autologous stem cell transplantation in relapsed and refractory Hodgkin's lymphoma. (springer.com)
  • Cortelazzo S, Rossi A, Viero P, Bellavita P, Marchioli R, Marfisi RM, Rambaldi A, Barbui T (1997) BEAM chemotherapy and autologous haemopoietic progenitor cell transplantation as front-line therapy for high-risk patients with diffuse large cell lymphoma. (springer.com)
  • Reduced-intensity conditioning regimens have been developed to minimise early toxic effects and deaths after allogeneic haemopoietic cell transplantation. (nih.gov)
  • Allogeneic stem cell transplantation after reduced intensity conditioning in patients with relapsed or refractory Hodgkin's lymphoma. (haematologica.org)
  • Background Although Hodgkin's lymphoma is a highly curable disease with modern chemotherapy protocols, some patients are primary refractory or relapse after first-line chemotherapy or even after high-dose therapy and autologous stem cell transplantation. (haematologica.org)
  • We investigated the potential role of allogeneic stem cell transplantation in this setting. (haematologica.org)
  • Conclusions Allogeneic stem cell transplantation can result in long-term progression-free survival in heavily pre-treated patients with Hodgkin's lymphoma. (haematologica.org)
  • Background The role of reduced-intensity conditioning allogeneic stem cell transplantation in relapsed/refractory Hodgkin's lymphoma remains poorly defined. (haematologica.org)
  • Forty-eight (83%) had undergone prior autologous stem cell transplantation. (haematologica.org)
  • However, the prognosis for many patients with relapsed and refractory disease remains poor.1-4 Many of them can be successfully salvaged with high-dose chemotherapy and autologous stem cell transplantation (SCT). (haematologica.org)
  • We report a single centre experience with haploidentical stem cell transplantation in 16 patients with poor prognosis myeloid and lymphoid malignancies refractory to conventional therapy or relapsing after autologous stem cell transplantation. (aspergillus.org.uk)
  • All patients had relapsed after or were refractory to conventional chemotherapy (11 patients) or had relapsed after autologous stem cell transplantation (5 patients). (aspergillus.org.uk)
  • BACKGROUND: Patients with severe combined immunodeficiency disease who have matched sibling donors (MSDs) can proceed to hematopoietic cell transplantation (HCT) without conditioning chemotherapy. (uzh.ch)
  • Acquired long QT syndrome during conditioning for allogeneic stem cell transplantation-are we aware of this side effect? (springer.com)
  • Sorror ML, Maris MB, Storb R, Baron F, Sandmaier BM, Maloney DG, Storer B (2005) Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. (springer.com)
  • Miller WP, Shanley R, Dorostkar P (2015) Cardiac QTc interval characteristics before and after hematopoietic stem cell transplantation: an analysis of 995 consecutive patients at a single center. (springer.com)
  • Professional oral cavity cleaning was selected as a factor to alleviate the severity of oral mucosal damage at the time of hematopoietic stem cell transplantation and the utility of oral care at the time of transplantation was proved. (nii.ac.jp)
  • Objective: High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHCT) is a well-defined treatment modality for relapsed/refractory non-Hodgkin s lymphoma (NHL) and Hodgkin s lymphoma (HL). (tjh.com.tr)
  • Sonis ST, Antin JH, Alterovitz G. SNP-Based Bayesian networks define OM risk in patients receiving somatotoxic conditioning regimens for autologous hematopoietic stem cell transplantation. (soligenix.com)
  • Genomic screening and complications of hematopoietic stem cell transplantation: has the time come? (nature.com)
  • Retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic hematopoietic stem cell transplantation using HLA-identical sibling donors in myelodysplastic syndromes. (ru.nl)
  • Toxoplasmosis is an often fatal opportunistic infection following allogeneic hematopoietic stem cell transplantation and is largely due to deferred diagnosis. (blogspot.com)
  • Stem cell transplantation significantly reduced the number of activated microglia after cyclophosphamide treatment in the brain. (aacrjournals.org)
  • Granule and pyramidal cell neurons within the dentate gyrus and CA1 subfields of the hippocampus exhibited significant reductions in dendritic complexity, spine density, and immature and mature spine types following chemotherapy, adverse effects that were eradicated by stem cell transplantation. (aacrjournals.org)
  • Get a quick, expert overview of hematologic and non-hematologic malignancies for which hematopoietic cell transplantation is a treatment option. (elsevierhealth.com)
  • Drs. Qaiser Bashir and Mehdi Hamadani provide easy-to-find information on basic science of hematopoietic cell transplantation, pharmacology, workflows and procedures, possible complications and side effects, in addition to the role of HCT in conjunction with clinical cellular therapy. (elsevierhealth.com)
  • HEMATOPOIETIC STEM CELL TRANSPLANTATION has been used for many years to treat various malignant and nonmalignant hematologic conditions. (cmaj.ca)
  • This review is intended as a basic overview of allogeneic and autologous stem cell transplantation with a special focus on long-term follow-up issues relevant to primary care providers. (cmaj.ca)
  • Stem cell transplantation can be performed with cells from a family member or an unrelated volunteer (allogeneic transplantation) or with stem cells previously collected from the patient (autologous transplantation). (cmaj.ca)
  • Because of the requirement for highly trained medical staff, stem cell transplantation is performed only at specialized centres. (cmaj.ca)
  • The strategy for management of relapsed or refractory disease is to deliver salvage chemotherapy, followed by high-dose chemotherapy and autologous stem-cell transplantation (AutoSCT) in responding patients [ 4 , 5 ]. (intechopen.com)
  • Therefore, G-CSF-combined conditioning before allogeneic stem cell transplantation might positively contribute to decreased incidences of relapse and graft failure without having to increase the dose of cytotoxic drugs. (elsevier.com)
  • We herein report the first case of X-linked agammaglobulinemia (XLA) that underwent allogeneic stem cell transplantation using reduced intensity conditioning (RIC). (biomedcentral.com)
  • The patient was a 28-year-old Japanese male with XLA who previously had life-threatening infectious episodes and was referred for the possible indication of allogeneic stem cell transplantation. (biomedcentral.com)
  • After a thorough discussion within specialists from different backgrounds, we decided to perform allogeneic peripheral stem cell transplantation from his HLA-identical elder brother. (biomedcentral.com)
  • Regarding immune reconstitution, CD19 + cells, IgA, and IgM, which were undetectable before allogeneic stem cell transplantation (allo-SCT), started to increase in number 10 days after allo-SCT and continued to increase for more than 1 year. (biomedcentral.com)
  • Although allogeneic stem cell transplantation (allo-SCT) is theoretically a curative option for XLA, the potential risks accompanying allo-SCT have been a barrier to it becoming a standard therapy for XLA. (biomedcentral.com)
  • [email protected]#To investigate the safety and efficacy of autologous peripheral blood hematopoietic stem cell transplantation (auto-PBHSCT) using modified BU/CY conditioning regimen for young AML patients of low and middle risk in the first complete remission (CR1). (bvsalud.org)
  • In severe cases, a liver transplantation may be necessary. (columbiasurgery.org)
  • In all other cases, a liver transplantation will be required. (columbiasurgery.org)
  • Liver transplantation is a surgical option for the treatment of liver failure where the diseased liver is replaced with a healthy one. (medindia.net)
  • Recently, one prospective study showed that a combination conditioning regimen of i.v. busulfan, cyclophosphamide, etoposide was found to be well tolerated and seemed to be effective in patients with aggressive NHL. (bioportfolio.com)
  • multiple myeloma patients showed that i.v. busulfan and melphalan conditioning regimen made no grade 3-4 non-hematological complication. (bioportfolio.com)
  • The investigators developed a protocol utilizing once-daily intravenous busulfan/melphalan/etoposide regimen as a conditioning for high-dose therapy (HDT) in the patients with high risk or. (bioportfolio.com)
  • The investigators developed a protocol comparing busulfan/cyclophosphamide/etoposide (BuCE) and busulfan/melphalan/etoposide (BuME) regimen as a conditioning for high-dose therapy (HDT) in. (bioportfolio.com)
  • The aim of this study is to determine whether the modified BuCy (semustine, cytarabine, busulfan, and cyclophosphamide, mBuCy) conditioning regimen can be safely used as an alternative to the SEAM (semustine, etoposide, cytarabine, and melphalan) regimen by comparing the efficacy and toxicity of the mBuCy and SEAM regimens. (springer.com)
  • The lack of suitable donors continues to be a limit to access to transplantation. (clinicaltrials.gov)
  • We conclude that transplantation from natural killer (NK) alloreactive haploidentical family donors offers potential cure to about one third of elderly patients with advanced leukemia or MDS considered incurable by other therapies. (aspergillus.org.uk)
  • OBJECTIVE: We sought to determine whether the results of HCT without chemotherapy-based conditioning from matched unrelated donors (URDs), either from volunteer adults or umbilical cord blood, are comparable with those from MSDs. (uzh.ch)
  • Allogeneic blood or marrow transplantation (alloBMT) is a curative therapy for a variety of hematologic disorders, including sickle cell disease and thalassemia. (clinicaltrials.gov)
  • Most children with non-malignant disorders present with normocellular or even hypercellular bone marrow, posing a barrier to engraftment and requiring intensive conditioning. (clinicaltrials.gov)
  • The Division of Blood and Marrow Transplantation (BMT) at Children's National Hospital is a leader in providing allogeneic blood and marrow transplantations for children with a variety of disorders. (childrensnational.org)
  • Since then, the BMT transplantation team has performed nearly 500 allogeneic blood and marrow transplantations. (childrensnational.org)
  • Children's National patients have access to cutting-edge treatments through several clinical trials for allogeneic blood and marrow transplantation. (childrensnational.org)
  • Blood and marrow transplantation is a special therapy for patients with cancer or other diseases which affect the bone marrow. (childrensnational.org)
  • Allogeneic bone marrow transplantation is the only curative therapy available for patients with these conditions. (childrensnational.org)
  • Transplantation conditioning is very common before bone marrow transplantation. (umassmed.edu)
  • BMT Statistical Unit, European Group for Blood and Marrow Transplantation Office, Universite' Pierre et Marie Curie, Paris, France. (unboundmedicine.com)
  • Linch DC, Winfield D, Goldstone AH, Moir D, Hancock B, McMillan A et al (1993) Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (springer.com)
  • Mills W, Chopra R, McMillan A, Pearce R, Linch DC, Goldstone AH (1995) BEAM chemotherapy and autologous bone marrow transplantation for patients with relapsed or refractory non-Hodgkin's lymphoma. (springer.com)
  • Objective: To examine the feasibility, safety and efficacy of bone marrow transplantation in high-risk adult patients with chronic granulomatous disease (CGD) using a modified low-toxicity conditioning regimen. (aspergillus.org.uk)
  • Objective A monoclonal antibody (mAb) against the leukocyte common antigen CD45 (RT7 in rats) could facilitate bone marrow transplantation (BMT). (uni-regensburg.de)
  • Bone Marrow Transplantation , 32 , S81-S83. (northwestern.edu)
  • For the journal abbreviated Bone Marrow Transplant , see Bone Marrow Transplantation (journal) . (wikipedia.org)
  • In 2006 a total of 50,417 first hematopoietic stem cell transplants were reported as taking place worldwide, according to a global survey of 1327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
  • The Worldwide Network for Blood and Marrow Transplantation reported the millionth transplant to have been undertaken in December 2012. (wikipedia.org)
  • In 2006, 50,417 first HSCTs were recorded worldwide, according to a global survey of 1,327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
  • Successful allogeneic bone marrow transplantation with reduced intensity conditioning regimen for a pediatric relapsed ALK positive anaplastic large cell lymphoma. (semanticscholar.org)
  • Bone marrow transplantation was first attempted, albeit unsuccessfully, in 1939, when human bone marrow cells were injected intravenously to treat a patient with aplastic anemia. (cmaj.ca)
  • 7 The use of blood stem cells is associated with faster recovery of neutrophils and platelets after transplantation (engraftment) than is the case with bone marrow stem cells. (cmaj.ca)
  • The Division of Bone Marrow Transplantation and Immune Deficiency at Cincinnati Children's is an international leader in delivering cutting-edge therapies for many diseases such as refractory, or hard-to-treat, cancers, rare genetic conditions affecting the immune system, hemoglobinopathies and bone marrow failure syndromes. (cincinnatichildrens.org)
  • The UC San Diego Health and Sharp HealthCare joint blood and marrow transplantation program is the largest blood and marrow transplant ( BMT ) program in San Diego and one of the largest in California. (ucsd.edu)
  • This study aimed to assess general trends in the use of various types of HSCTs performed between 2001 and 2015 in Europe, based on data reported to the European Society for Blood and Marrow Transplantation registry. (springer.com)
  • He also has an appointment with the Division of Blood and Marrow Transplantation at the Markey Cancer Center. (scientificamerican.com)
  • GVHD is a significant consideration because stem cells from a donor's bone marrow often recognize the host as foreign, resulting in complications after transplantation. (scientificamerican.com)
  • Antin, Joseph H. is the author of 'Dana-Farber Manual of Stem Cell and Bone Marrow Transplantation', published 2009 under ISBN 9780521699754 and ISBN 0521699754. (valorebooks.com)
  • Thus, the local skin damage caused by the conditioning regimen appears to be insufficient as single factor to provoke GVHD induction. (frontiersin.org)
  • Reduced incidence of GVHD after TCD alloSCT with postponed DLI may partly be explained by gradual repair in time of the tissue damage caused by the pretransplant conditioning regimen. (frontiersin.org)
  • We used proportional subdistribution hazards model (Fine-Gray) for competing risks to identify predictors of grade 3-5 CHCs, adjusting for demographics, primary disease, conditioning agents, disease status at BMT and chronic GvHD status. (confex.com)
  • While survival of these patients is typically better than survival of patients with malignancies, toxicities of conditioning regimens and failure of engraftment remain challenges. (clinicaltrials.gov)
  • Treatment-related mortality and recurrence of disease account for the majority of treatment failures in allogeneic transplantation for advanced hematologic malignancies. (knowcancer.com)
  • Intensified conditioning represents a promising approach for high-risk hematological malignancies, although it affects early immune reconstitution of recipients and increases the incidence and mortality of EBV infections. (biomedcentral.com)
  • The frequent use of chemotherapy to combat a range of malignancies can elicit severe cognitive dysfunction often referred to as "chemobrain," a condition that can persist long after the cessation of treatment in as many as 75% of survivors. (aacrjournals.org)
  • A Retrospective Comparison of TECAM and BEAM Conditioning Regimens Before Autologous Hematopoietic Stem Cell Transplant in Lymphoma Patients: Efficacy and Toxicity. (bioportfolio.com)
  • We examined the effect of a reduced-intensity conditioning regimen designed to enhance myeloid engraftment and reduce organ toxicity in these patients. (uzh.ch)
  • Currently, the combination of cyclophosphamide and antithymocyte globulin (ATG) is considered the best conditioning regimen for patients with a diagnosis of AA undergoing an HLA-identical related trans-plant.38'40'43 44 In a majority of studies, use of irradiation was associated with lower rejection rates but significantly higher TRM. (clicktocurecancer.info)
  • b) Overall survival according to the conditioning regimen with cyclophosphamide plus either antithymocyte globulin (Cy-ATG) or thoracoabdominal irradiation (Cy-TAI). (clicktocurecancer.info)
  • Dr. Wanzhang Yang, who led the study at Nanshan Affiliated Hospital of Guangdong Medical College commented, 'This important study, which is the largest of its kind, demonstrates the safety and efficacy of using cord-blood-derived stem cells to treat a variety of neurological conditions. (news-medical.net)
  • However, it also suggests cord-blood-derived stem cells are a safe and viable treatment option for a much broader range of diseases and conditions than previously thought. (news-medical.net)
  • In our clinical practice, we perform transplantations of autologous synovial mesenchymal stem cells (MSCs) for cartilage and meniscus regenerative medicine. (biomedcentral.com)
  • Intrahippocampal transplantation of human neural stem cells resolved all cognitive impairments when animals were tested 1 month after the cessation of chemotherapy. (aacrjournals.org)
  • Our findings provide the first evidence that cranial transplantation of stem cells can reverse the deleterious effects of chemobrain, through a trophic support mechanism involving the attenuation of neuroinflammation and the preservation host neuronal architecture. (aacrjournals.org)
  • However, this was overshadowed by toxicities, which resulted in a similar overall survival, establishing Cy/TBI (12 Gy) as the standard conditioning before transplantation [ 14 ]. (hindawi.com)
  • There was no impact of conditioning regimen intensity in overall survival (OS) in AML (HR = 0.97, p = 0.79) but a trend for worse OS with RIC in ALL (HR = 1.44, p = 0.10). (uni-muenchen.de)
  • The five patients transplanted with the reduced intensity conditioning (4 in complete remission (CR) and 1 in non-CR) had a significantly better survival rate than 10 patients transplanted with a conventional conditioning (4 in CR and 6 in non-CR) (3-year EFS (95% confidence interval): 80.0% (20.4-96.9%) vs. 10.0% (0.6%-35.8%), P=0.039). (elsevier.com)
  • a) Overall survival of 133 patients who underwent transplantation at the Hospital St. Louis (median follow-up of 13.6 years). (clicktocurecancer.info)
  • This retrospective study shows that the G-CSF-combined conditioning regimen provides better engraftment and survival results in CBT for adults with MDS and sAML. (elsevier.com)
  • The side effects of the conditioning regimen, hematopoietic recovery time, transplant-related mortality (TRM) within 100 days and 1 year after auto-PBHSCT, relapse rate, leukemia-free survival (LFS) rate at 2 years and 3 years, overall survival (OS) were evaluated at 3 years and 4 years. (bvsalud.org)
  • The median follow-up time was 48.1 months, and the median survival time was 54.7 months after transplantation. (bvsalud.org)
  • In the transplantation discipline, collection of data from clinical trials will continue to improve knowledge, thereby helping to increase survival rates. (scientificamerican.com)
  • Despite being curative for a significant proportion of patients, post-transplant relapse remains a challenge in the reduced intensity conditioning setting. (haematologica.org)
  • Non relapse mortality occurred in 4 of 16 (25%) patients within 1 year after transplantation. (aspergillus.org.uk)
  • Disease progression and relapse occurred in 6 patients within 1 year after transplantation (myeloma 1, AML 5). (aspergillus.org.uk)
  • However, based on the higher risk of relapse, patients with no contraindications for SMC should not receive RIC outside of prospective randomized trials, which are needed to establish the position of RIC-based transplantation in the treatment of patients with MDS. (ru.nl)
  • 6-8 Recently, a report on 55 patients younger than age 55 years with MMM who underwent allogeneic hematopoietic stem cell (HSC) transplantation indicated that 48% of the recipients of an HLA-identical transplant survived event-free at 5 years. (bloodjournal.org)
  • A recent shortage of melphalan has prompted the use of alternatives to BEAM (BCNU, Etoposide, Cytarabine, Melphalan) conditioning for autologous stem cell transplantion (ASCT). (bioportfolio.com)
  • Anti-thymocyte globulin (ATG) has been used in severe aplastic anemia as a part of the conditioning regimen. (centerwatch.com)
  • Cord blood transplantation (CBT) has become an alternative treatment means in various diseases, but it has not been proved to be good for severe aplastic anemia. (centerwatch.com)
  • 3.0 × 10 7 nucleated cells/kg) or of two partially matched UCB units (dUCB) is feasible and allows satisfactory engraftment, which contributed to the development of RIC regimens in UCB transplantation. (nature.com)
  • Because one patient (UPN11) received extra medication during the conditioning phase due to rapid disease progression, the patient was considered as evaluable only for engraftment. (bloodjournal.org)
  • the benefits of good engraftment would be maintained with this three drug conditioning regimen and that the toxicities from this treatment would be reduced to an acceptable level. (aamds.org)
  • Abandonment of alpha/beta TCR+ cell depletion fromBMgrafts impaired the engraftment process after conditioning using 15 mg/kg of the mAb in theMHC syngeneic setting (2 of 6 recipients failed to engraft) and the MHC haploidentical setting (3 of 6 recipients failed). (uni-regensburg.de)
  • Conclusion This depletive anti-RT7(a) mAb ismyelosuppressive and conditions for engraftment of MHC syngeneic BM. (uni-regensburg.de)
  • This section describes the 4 components of allogeneic transplantation - conditioning, transplantation, engraftment and immunoreconstitution ( Fig. 2 ) - and provides information about the patient's hospital stay and the risks associated with this type of transplantation. (cmaj.ca)
  • METHODS: We performed a multicenter survey of severe combined immunodeficiency transplantation centers in North America, Europe, and Australia to compile retrospective data on patients who have undergone unconditioned HCT from either URDs (n = 37) or MSDs (n = 66). (uzh.ch)
  • In this article we aim to familiarize primary care practitioners with some of the basics of allogeneic and autologous transplantation, as well as issues relevant to the care of transplant recipients over the short and the long term. (cmaj.ca)
  • Until now, patients receiving cord blood transplants to fight hematopoietic diseases were immune-suppressed in order to prevent a potentially devastating condition known as 'graft versus host. (news-medical.net)
  • For which diseases or conditions is umbilical cord blood stem-cell therapy most effective? (scientificamerican.com)
  • He has received formal training in Advanced Heart Failure and has a wide range of experience in the care of patients with heart failure, assist devices and heart transplantation. (mcw.edu)
  • Dr. Gaglianello specializes in the comprehensive, longitudinal care of patients with all etiologies of heart failure and cardiomyopathy, utilizing the latest available medical, surgical and device therapies and heart transplantation. (mcw.edu)
  • Recent advances have now allowed alloSCT to be extended to older patients through the use of reduced-intensity conditioning regimens. (bloodjournal.org)
  • Other conditions [13] treated with stem cell transplants include sickle-cell disease , myelodysplastic syndrome , neuroblastoma , lymphoma , Ewing's sarcoma , desmoplastic small round cell tumor , chronic granulomatous disease , Hodgkin's disease and Wiskott-Aldrich syndrome . (wikipedia.org)
  • We sought to evaluate the efficacy of a reduced-intensity conditioning regimen for allogeneic HSC transplantation in this setting. (bloodjournal.org)
  • MHC disparate BM resulted in autologous reconstitution after conditioning by 10mg/kg of the mAb and caused transient chimerism ending up in death associated with aplasia after conditioning by 15mg/kg of the mAb. (uni-regensburg.de)
  • Recently, older recipients of allogeneic HSC transplantation have been treated successfully following a variety of less intensive nonmyeloablative conditioning regimens. (bloodjournal.org)
  • The Metabolic Bone Clinic provides comprehensive evaluation, diagnosis and management of various skeletal disorders, including Osteogenesis Imperfecta (OI) and other congenital bone disorders, as well as acquired conditions that led to osteopenia and impair bone such as that seen with glucocorticoid use, immobilization and chronic renal, liver and other conditions. (nationwidechildrens.org)
  • However, the high-dose conditioning regimen can lead to major organ dysfunction, life-threatening infection and bleeding. (cmaj.ca)
  • Children's National's BMT team works closely with the Division of Genetics and Metabolism and the Division of Neurology to provide a comprehensive management program for children with these diseases undergoing allogeneic transplantation. (childrensnational.org)