The transference of a part of or an entire liver from one human or animal to another.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The transference of a kidney from one human or animal to another.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
The transference of a heart from one human or animal to another.
Transplantation of an individual's own tissue from one site to another site.
The transference of either one or both of the lungs from one human or animal to another.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Transference of an organ between individuals of the same species or between individuals of different species.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
The transference of a pancreas from one human or animal to another.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Elements of limited time intervals, contributing to particular results or situations.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Prospective patient listings for appointments or treatments.
Transplantation between animals of different species.
The return of a sign, symptom, or disease after a remission.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Partial or total replacement of the CORNEA from one human or animal to another.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A dead body, usually a human body.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
Pathological processes of the LIVER.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
Therapeutic act or process that initiates a response to a complete or partial remission level.
The transference of a complete HAND, as a composite of many tissue types, from one individual to another.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
The period following a surgical operation.
Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.
Disease having a short and relatively severe course.
Progenitor cells from which all blood cells derive.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Immunological rejection of leukemia cells following bone marrow transplantation.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Immunological rejection of tumor tissue/cells following bone marrow transplantation.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Providers of tissues for transplant to non-related individuals.
Tumors or cancer of the LIVER.
Excision of all or part of the liver. (Dorland, 28th ed)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
Disorders of the blood and blood forming tissues.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
An individual that contains cell populations derived from different zygotes.
Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.
Tissues, cells, or organs transplanted between genetically different individuals of the same species.
The induction of prolonged survival and growth of allografts of either tumors or normal tissues which would ordinarily be rejected. It may be induced passively by introducing graft-specific antibodies from previously immunized donors, which bind to the graft's surface antigens, masking them from recognition by T-cells; or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).
Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.
The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.
A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The process by which a tissue or aggregate of cells is kept alive outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Antibodies produced by a single clone of cells.
Veins which drain the liver.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
Pathological processes of the KIDNEY or its component tissues.
The physiological renewal, repair, or replacement of tissue.
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
The innermost membranous sac that surrounds and protects the developing embryo which is bathed in the AMNIOTIC FLUID. Amnion cells are secretory EPITHELIAL CELLS and contribute to the amniotic fluid.
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Tissue, organ, or gamete donation intended for a designated recipient.
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
A general term for various neoplastic diseases of the lymphoid tissue.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)

Organ transplantation--then and now. (1/498)

The last 25 years have seen amazing progress in transplantation--from the development of techniques for immunosuppression to methods for organ removal and preservation. Our distinguished authors focus on these developments and discuss how the momentum seen during the last quarter century can be accelerated.  (+info)

Transplant surgeons in training: is anybody out there? (2/498)

There is a long-standing recognition that there is an organ donor shortage in the United Kingdom and Ireland (UK&E) that limits transplant activity. However, the fact that, at present, there are several unfilled consultant vacancies would suggest that a shortage of trained surgeons may soon be an equally important limiting factor. The aim of this current study was to identify all transplant trainees in the UK&E and to determine their career aspirations. A list of all trainees intending to practice as transplant surgeons was compiled. A combination of postal questionnaire and telephone interview was used to construct a database on past and present training in transplantation, and preferred type of consultancy was assessed both by direct questioning and by using a visual analogue scale to grade desirability of various posts. Of 110 potential trainees identified, 50 (45%) replied and indicated a desire to pursue a career in transplant surgery. Thirty-one intended practising in the UK&E (19 UK&E graduates and 12 overseas). The preferred consultancy (27/31) was transplantation (Tx) together with a second specialty while only four wanted a multivisceral practice. The mean score (0-10) for desirability of a multivisceral transplant post was 4.7, for renal transplant and vascular access it was 3.6 and for transplantation and a second specialty it was 8.4. We conclude that the majority of trainees do not wish to apply for pure transplant posts, either single organ or multivisceral, and that the majority wish to practice transplantation with a second specialty. In addition, there is still a major shortage of trainees and further studies are required to identify reasons why trainees fail to pursue a career in transplantation.  (+info)

Gene targeting: applications in transplantation research. (3/498)

Gene targeting, the manipulation of gene in the mouse genome using homologous recombination in embryonic stem cells, is a powerful experimental tool that has been widely utilized in a number of disciplines. The ability to precisely alter genes in this way provides an avenue for investigating the role of a gene product in normal and pathological processes in the intact animal, with a precision and efficacy not possible using pharmacological agents, antibodies or engineered proteins. In transplant research, gene targeting provides a unique tool for discriminating the contributions of gene expression in donor versus recipient tissues. This review focuses on several areas in transplantation research where gene targeting has made useful contributions. These include studies of the role of donor and recipient multiple histocompatibility complex antigens in regulating rejection responses, the role of CD4+ T cell in mediating acute rejection, and the functions of cytokines during rejection and tolerance induction. These studies highlight the unique advantages of gene targeting in studies of complex processes in whole animals and illustrate the contributions of this technique to understanding the pathogenesis of allograft rejection.  (+info)

Gene therapy in transplantation in the year 2000: moving towards clinical applications? (4/498)

Transplantation faces several major obstacles that could be overcome by expression of immunomodulatory proteins through application of gene therapy techniques. Gene therapy strategies to prolong graft survival involve gene transfer of immunosuppressive or graft-protecting molecules. Very promising results have been obtained in small animal experimental models with inhibitors of co-stimulatory signals on T cells, immunosuppressive cytokines, donor major histocompatibility antigens and regulators of cell apoptosis or oxidative stress. The application of gene therapy techniques to transplantation offers a great experimental and therapeutic potential. Local production of immunosuppressive molecules may increase their therapeutic efficiency and reduce their systemic effects. When compared with other clinical situations, gene therapy in transplantation offers several potential advantages. Gene transfer into the graft can be performed ex vivo, during the transit between the donor and the recipient, thus avoiding many of the hurdles encountered with in vivo gene transfer. Furthermore, the difficulties associated with immune responses to the gene transfer vectors and transient gene expression may be easier to overcome when gene therapy protocols are applied to transplantation than when applied to other clinical situations. The next century should witness a rapid increase in the application of gene therapy techniques to large animal pre-clinical models of transplantation and later to clinical trials. Gene Therapy (2000) 7, 14-19.  (+info)

The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders. (5/498)

Whereas the standard immunosuppressive agents foster development of posttransplant lymphoproliferative disorders (PTLDs), the impact of RAD, a macrolide with potent immunosuppressive properties, and other immunosuppressive macrolides on these disorders remains undetermined. We found that RAD had a profound inhibitory effect on in vitro growth of six different PTLD-like Epstein-Barr virus+ lymphoblastoid B cell lines. Similar to normal T cells, RAD blocked cell-cycle progression in PTLD-like B cells in the early (G(0)/G(1)) phase. Furthermore, RAD increased the apoptotic rate in such cells. The drug also had a profound inhibitory effect on the growth of PTLD-like Epstein-Barr virus+ B cells xenotransplanted s.c. into SCID mice. The degree of the RAD effect varied among the three B cell lines tested and was proportional to its effects on the cell lines in vitro. In this in vivo xenotransplant model, RAD markedly delayed growth or induced regression of the established tumors. In one line, it was able to eradicate the tumor in four of eight mice. When RAD treatment was initiated before tumor cell injection, a marked inhibition of tumor growth was seen in all three lines. In two of them, the drug prevented tumor establishment in approximately 50% of mice (5/11 and 5/8). In summary, RAD is a potent inhibitor of PTLD-like cells in vitro and in vivo. These findings indicate that, in contrast to the standard immunosuppressive agents, macrolides such as RAD may be effective in prevention and treatment of PTLDs.  (+info)

Comparison of quantitative cytomegalovirus (CMV) PCR in plasma and CMV antigenemia assay: clinical utility of the prototype AMPLICOR CMV MONITOR test in transplant recipients. (6/498)

The correlation between the prototype AMPLICOR CMV MONITOR test (Roche Molecular Systems), a quantitative PCR assay, and the cytomegalovirus (CMV) pp65 antigenemia assay was evaluated in transplant recipients. Sequential blood specimens were collected on 29 patients (491 specimens), the leukocyte fraction was tested by CMV antigenemia, and quantitative PCR was performed on plasma specimens. None of the 15 patients (242 specimens) who were antigenemia negative were positive for CMV DNA by PCR, and none of these patients developed active CMV disease. There were 14 antigenemia-positive patients, 8 of whom developed active CMV disease. In all patients, there was a good association between the antigenemia and PCR assays. Ganciclovir-resistant virus was isolated from three patients with active CMV disease. These three patients had persistently elevated levels of antigenemia and CMV DNA by PCR when resistance to ganciclovir developed. This standardized, quantitative CMV PCR assay on plasma has clinical utility for the diagnosis of active disease and in monitoring the response to antiviral therapy in transplant recipients.  (+info)

Transcatheter implantation of a bovine valve in pulmonary position: a lamb study. (7/498)

BACKGROUND: Pulmonary regurgitation can lead to severe right ventricular dysfunction, which is a delicate postoperative problem in the long-term follow-up of patients who had surgery for congenital heart diseases. Clinical conditions of patients suffering from pulmonary valve incompetence are improved by valve replacement with a prosthetic valve. To date, the surgical approach is the only option to replace a pulmonary valve. We report the first experience of percutaneous pulmonary valve implantation. METHODS AND RESULTS: A fresh bovine jugular vein containing a native valve was sutured into a vascular stent and then cross-linked with a 0.6% glutaraldehyde solution for 36 hours. After being hand-crimped onto a balloon catheter, the device was inserted percutaneously according to standard stent-placing techniques. The valved stent was finally deployed in the position of the native pulmonary valve of the lamb. Hemodynamic evaluation was carried out before and 2 months after implantation. Anatomic evaluation was finally performed. Percutaneous pulmonary valve replacement was successful in 5 lambs. No complications were noted. Early and late angiographic and hemodynamic studies confirmed a good position of the stents with a competent valve at the end of the protocol. One stent was slightly stenotic, with macroscopically visible calcifications. CONCLUSIONS: Nonsurgical implantation of pulmonary valves is possible in the lamb. This new technique is similar to standard stent implantation. Thus, it should be feasible in humans, in whom it will lead to a significant reduction of reoperations in patients in need of pulmonary valve replacement.  (+info)

Therapeutic surgery in failures of medical treatment for fungal keratitis. (8/498)

Medical treatment failure necessitated surgery in nine cases of fungal keratitis. Therapeutic surgery eliminated fungal infection in seven cases, and useful vision was retained in five out of six penetrating keratoplasties. In three cases Natamycin (Pimaricin) therapy rendered fungi non-viable, but two were demonstrable by histopathology. These results suggest that antifungal treatment should be applied for as long as possible before therapeutic surgery in order to improve the final visual outcome.  (+info)

American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Avoidance of long-term immunosuppression is a desired goal in organ transplantation. Mixed chimerism offers a promising approach to tolerance induction, and we have aimed to develop low-toxicity,.... ...
The American Society of Transplantation is dedicated to advancing the field of transplantation and improving patient care by promoting research, education, advocacy, organ donation, and service to the community.. ...
SOUTH SAN FRANCISCO, Calif., May 09, 2016-- Atara Biotherapeutics, Inc., a biopharmaceutical company focused on developing meaningful therapies for patients with severe and life-threatening diseases that have been underserved by scientific innovation, today announced that an oral presentation, entitled
Submit Late Breaking Abstract This site is available for late breaking data only. Abstracts submitted for late breaking consideration that do not include research conducted after December 2, 2017, will not be considered for presentation. Deadline: January 26, 2018, 11:59 PST
S. Park1, C. Baek2, M. Yu3, Y. Kim1, J. Moon1, H. Go2, Y. Kim2, J. Lee4, S. Min1, J. Ha1, K. Moon1, Y. Kim1, C. Ahn1, S. Park2, H. Lee1. ...
R. Charco, G. Sapisochin, C. Rodriguez-Lope, M. Gastaca, J. Ortiz de Urbina, R. Lopez-Andujar, F. Palacios, E. Ramos, J. Fabregat, J. Castroagudin, E. Varo, J. Pons, P. Parrilla, M. Gonzalez-Dieguez, M. Rodriguez, A. Otero, M. Vazquez, G. Zozaya, J. Herrero, G. Sanchez Antolin, B. Perez, R. Ciria, S. Rufián, Y. Fundora, J. Ferrón, A. Guiberteau, G. Blanco, M. Varona, M. Barrera, M. Suarez, J. Santoyo, J. Bruix ...
Teleflex Incorporated (NYSE:TFX) , a leading global provider of medical devices for critical care, urology and surgery, will showcase its range of interventional products at the 52nd European Renal, Dialysis and Transplant Congress in London on May 28 - 31, 2015. During the event, Teleflex will highlight its Arrow(R) chronic hemodialysis catheter portfolio, which offers both split-tip and step-tip catheters for both retrograde and antegrade insertion techniques. The Arrow(R) NextStep(R) Retrograde and Antegrade product family consists of step-tip catheters that can easily be inserted and tunneled using retrograde or antegrade technique, respectively. These step-tip catheters also have the advantage of split-tip high flow characteristics. The step-tip on these catheters is designed for smooth, over-the-wire transitions during insertions and exchanges. The Arrow(R) Cannon(R) II Plus and Arrow Edge(R) products are split-tip catheters that can be tunneled using retrograde or antegrade technique, ...
The Healthcare-Associated Infections Surveillance Network (HAI-Net) is a European network for the surveillance of healthcare-associated infections (HAI). The network is coordinated by the ECDC.. Activities of the Healthcare-associated Infections Surveillance Network (HAI-Net) are:. ...
Dr. Manikkam Suthanthiran pursues research in transplantation immunology and molecular biology to improve outcomes following organ transplantation.. Molecular Medicine. Dr. Suthanthirans laboratory has pioneered the development of noninvasive gene-based assays to ascertain kidney transplant status, which had previously required an invasive kidney biopsy procedure. The original study, first conducted at Weill Cornell, led to an NIH-sponsored multicenter Cooperative Clinical Trial in Transplantation comprised of 500 subjects from major transplant centers in the United States. Results of the molecular studies of transplant recipients were presented at the plenary sessions of the 2011 American Transplant Congress Annual Meeting and the 2011 International Transplantation Society Meeting. Based on the bench-to-bedside approach, this study has led to state-of-the-art, individualized care (personalized medicine) of kidney transplant recipients. Recently, Dr. Suthanthiran and his research team have ...
Patients who receive transplanted kidneys from deceased donors (DDs) age 60 and older with acute kidney injury (AKI) have worse allograft outcomes than some other DD kidney recipients, according to new research discussed at the 2019 American Transplant Congress in Boston.. A team led by J. Kim, MD, of Daejeon St. Marys Hospital at the Catholic University of Korea, examined clinical outcomes for 709 kidney transplant recipients (KTRs) receiving kidneys from 569 DDs at 4 transplant centers. For analyses, KTRs were stratified by donor age (younger or older than 60 years) and the presence of donor AKI. Allograft function deteriorated significantly more in recipients of AKI kidneys from older versus younger DDs: Estimated glomerular filtration rate (eGFR) was 46.8 vs 56.0; 45.3 vs 56.0; and 46.7 vs 61.4 mL/min/1.73 m2 at 3, 6, and 12 months after transplant, respectively, by the Modification of Diet in Renal Disease equation. At 12 months, grafts from AKI-young DDs fared similarly to those from ...
The research interests of Sadia Shah, M.D., are in Interstitial Lung Disease, Lung Transplant and Larynx-Trachea Transplant. She is a member of International Society of Heart and Lung Transplantation and American Transplant Congress. She is part of Mayo Clinic Transplant Convergence Group which collaborates between Mayo Clinic Arizona, Minnesota and Florida Transplant Division to ensure that all sites provide the latest and best care to lung transplant patients that the world has to offer.. Dr. Shah is currently the Interim Medical Director for Lung Transplant Program at Mayo Clinic Arizona and has been involved with re-launching of the program. She is also the Medical Director for Larynx-Trachea Transplant Program at Mayo Clinic, Arizona.. Focus areas. ...
As Professor of Surgery and Director of the Abdominal Transplant Fellowship Program at UCSF, Dr. Sandy Feng performs liver, kidney and pancreas transplants and teaches surgical fellows, residents, and medical students. She received a doctorate in molecular biology from Cambridge University with her Marshall Scholarship and earned her medical degree at Stanford University School of Medicine. She then completed general surgery residency at the Brigham and Womens Hospital in Boston and a transplant fellowship at the University of California, San Francisco.. Dr. Feng has numerous leadership roles, including Councilor for the American Society of Transplant Surgeons, Deputy Editor for the American Journal of Transplantation, former Co-Chair of the Executive Planning Committee for the American Transplant Congress, and current Chair of the Kidney Pancreas Advisory Committee of the American Society of Transplantation. She has been an invited organizer or participant in several national consensus ...
TY - JOUR. T1 - Clinical and economic consequences of first-year urinary tract infections, sepsis, and pneumonia in contemporary kidney transplantation practice. AU - Naik, Abhijit S.. AU - Dharnidharka, Vikas R.. AU - Schnitzler, Mark A.. AU - Brennan, Daniel C.. AU - Segev, Dorry L.. AU - Axelrod, David. AU - Xiao, Huiling. AU - Kucirka, Lauren. AU - Chen, Jiajing. AU - Lentine, Krista L.. N1 - Funding Information: The data reported here have been supplied by the United States Renal Data System (USRDS). The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy or interpretation of the United States government. This work was supported by a grant from the National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R0-1DK102981. An abstract describing portions of this work was presented at the 2015 American Transplant Congress in Philadelphia, PA, May 3, 2015. Support ...
Nov 2011 - May 2015: Community Relations Coordinator, Donor Alliance. Jan 2009 - Dec 2013: Board Member, Colorado Healthcare Communicators. Jan 2011 - Sep 2011: Communication and Special Event Consultant, American Transplant Foundation. May 2008 - Sep 2010: Outreach & External Affairs Coordinator, American Transplant Foundation. Jan 2008 - Apr 2008: Communications Intern, American Transplant Foundation. - Denver, CO
Over the past forty years, the use of increasingly effective immunosuppressive drugs has decreased the risk for organ rejection (acute rejection, AR) considerably, and improved short-term outcomes. However, these costly and complicated life-long treatment regimens also cause serious complications in the long-term.. While transplant recipients live significantly longer lives than patients on dialysis, transplant recipients still have much shorter life spans than their healthy counterparts. Among reasons for this difference in life-expectancy are the immunosuppressive-drug related side effects that can lead to complications such as life threatening infections, malignancies, high blood pressure, heart disease, and diabetes. Additionally, certain drugs used to prevent organ rejection are known to contribute to renal damage, leading many patients to experience graft loss within 15 years. To that end, many children undergoing successful kidney transplantation require re-transplantation as adults. ...
Ajay Sharma, MD, Department of Paediatrics, University of Western Ontario, Childrens Hospital, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario, Canada N6A 5W9 Tel.: +1 519 685 8500 (ext. 58379) Fax: +1 519 685 8156 E-mail ...
ERN TransplantChild awards this grants to healthcare professionals who are currently dedicated to paediatric transplantation and wish to pursue a short-term training stay in any of the 25 health care providers (HCPs) members or affiliated partners of TransplantChild.. Get more information here.. ...
Kunzler de Oliveira Maia, F., Tekin, A., Nicolau-Raducu, R., Beduschi, T., Selvaggi, G., Vianna, R., Ammar Al Nuss, M., González, J., Gaynor, J. J. & Ciancio, G., Jan 1 2019, (Accepted/In press) In : Pediatric Transplantation. e13596.. Research output: Contribution to journal › Article ...
Alam, Z., VanderBrink, B. A., Brewer, N., Hooper, D., Tiao, G., Alonso, M., Nathan, J., DeFoor, W. R., Sheldon, C. & Reddy, P. P., Jan 1 2019, In : Pediatric Transplantation. 23, 5, e13453.. Research output: Contribution to journal › Article ...
TY - JOUR. T1 - Indoleamine 2,3-dioxygenase inhibition alters the non-coding RNA transcriptome following renal ischemia-reperfusion injury. AU - Merchen, Todd D.. AU - Boesen, Erika I.. AU - Gardner, John R.. AU - Harbarger, Rachel. AU - Kitamura, Eiko. AU - Mellor, Andrew. AU - Pollock, David M.. AU - Ghaffari, Arina. AU - Podolsky, Robert. AU - Nahman, N. Stanley. N1 - Funding Information: No conflicts. Supported by the Carlos and Marguerite Mason Trust (AM, TDM), a Clinical Investigator Award (TDM) and seed grant (TDM) from the Cardiovascular Discovery Institute, Georgia Regents University , a seed grant from the Immunotherapy Center, Georgia Regents University (NSN), and a research grant from the Augusta Biomedical Research Corporation, Augusta, Georgia (NSN). Portions of this work were previously presented at the 2012 American Transplant Congress 2012 and published in the American Journal of Transplantation: 13 (S5):385, 2013 and 13 (S5):386, 2013. Copyright: Copyright 2014 Elsevier B.V., ...
Brain-dead donor organ transplantation has been available to children in Japan since the 2010 revision of the Organ Transplant Law. Of the 50-60 brain-dead donor organ transplants performed annually in Japan, however, very few (0-4 per year) are performed in children. Again, while those receiving liver, heart, and kidney transplants are reported to fare better than their counterparts in the rest of the world, organ shortage is becoming a matter of great concern. Very few organs become available from brain-dead donors or are transplanted to adults if made available at all, with some children dying while on the brain-dead organ waiting list. Against this background, living-donor transplants, split-liver transplants, domino transplants, and hepatocyte transplants represent alternative modalities, each of which is shown to be associated with favorable outcomes. Challenges exist, include streamlining the existing framework for promoting organ donation for children and between children.
1. Therapeutic options in hypertrophic cardiomyopathy: a pediatric perspective. Rhee EK. Nigro JJ. Pophal SG. Current Treatment Options in Cardiovascular Medicine. 10(5):433-41, 2008. 2. Left hemitruncus associated with tetralogy of fallot: fetal diagnosis and postnatal echocardiographic and cardiac computed tomographic confirmation. Diab K. Richardson R. Pophal S. Alboliras E. Pediatric Cardiology. 31(4):534-7, 2010. 3. Improved exercise performance in pediatric heart transplant recipients after home exercise training. Patel JN. Kavey RE. Pophal SG. Trapp EE. Jellen G. Pahl E. Pediatric Transplantation. 12(3):336-40, 2008. 4. Case-control study of risk factors for the development of post-transplant lymphoproliferative disease in a pediatric heart transplant cohort. Katz BZ. Pahl E. Crawford SE. Kostyk MC. Rodgers S. Seshadri R. Proytcheva M. Pophal S. Pediatric Transplantation. 11(1):58-65, 2007. 5. Ryan J1, Gregg C, Frakes D, Pophal S. Three-dimensional printing: changing clinical care or just ...
At least 32 young children have died since 2000 after failing to receive a heart transplant - a sign of South Africas faltering organ donation and transplantation programmes.. In one hospital in a five-year period from 2010 to 2014, two children received heart transplants while 10 died while wait-listed for a transplant.. These figures are directly linked to government policy, the nations poor commitment to organ donation generally and the difficulty of matching a young recipient to a small donor heart.. Only 80 children have received a heart transplant in this country in the 40 years that programmes have been operating, an average of two procedures a year.. According to figures presented by cardiothoracic surgeon Dr Susan Vosloo of the Christiaan Barnard Memorial Hospital at the Heart Transplant Society congress in Gordons Bay last week, the transplant programme for children started at Red Cross Childrens Hospital in association with Groote Schuur Hospital in Cape Town in 1980.. In the ...
The Pediatric Transplantation Program at Yale New Haven Childrens Hospital leads the way in providing expert, comprehensive and compassionate care to children with acute and chronic liver and kidney failure
Transplant-Associated and Blood Transfusion-Associated Tropical and Parasitic Infections: Blood transfusion and transplantation may represent efficient mechanis
M. J. Osorio, A. Bonow, G. J. Bond, et al. Abernethy malforma- tion complicated by hepatopulmonary syndrome and a liver mass successfully treated by liver transplantation. Pediatric Transplantation, 2011, 15(7): E149-E151.
Suresh, S., Upton, J., Green, M., Pham-Huy, A., Posfay-Barbe, K. M., Michaels, M. G., Top, K. A., Avitzur, Y., Burton, C., Chong, P. P. E., Danziger-Isakov, L., Dipchand, A. I., Hébert, D., Kumar, D., Morris, S. K., Nalli, N., Ng, V. L., Nicholas, S. K., Robinson, J. L., Solomon, M. & 4 others, Tapiero, B., Verma, A., Walter, J. E. & Allen, U. D., Jan 1 2019, (Accepted/In press) In : Pediatric Transplantation. e13571.. Research output: Contribution to journal › Article ...
Abcam provides specific protocols for Anti-HLA Class I antibody [W6/32] (ab22432) : Flow cytometry protocols, Immunoprecipitation protocols…
Rejection and infection are primary causes of morbidity and mortality in solid organ transplant recipients. Current clinical practice relies on immunosuppressive drug levels measured in plasma to reflect the peripheral immune response in solid organ transplant recipients. Direct measurement of the number and functions of the immune cells themselves using multi-parameter flow cytometry may enable individualized immunosuppression management for organ transplant recipients. Multi-parameter flow cytometry will be used to compare levels and functional capabilities of multiple lymphocyte subsets between cohorts of patients receiving depletion induction and those receiving a non-depletion regimen. The activation state, cytotoxic potential and the functional capabilities of these cells will be examined within patients over the first six months post transplant ...
TY - JOUR. T1 - Graft failure after infant heart transplantation. T2 - Impact of extracorporeal membrane oxygenation on outcomes. AU - Mettler, B.. N1 - Copyright: Copyright 2014 Elsevier B.V., All rights reserved.. PY - 2014/2. Y1 - 2014/2. UR - UR - U2 - 10.1111/petr.12199. DO - 10.1111/petr.12199. M3 - Editorial. C2 - 24384044. AN - SCOPUS:84891756807. VL - 18. SP - 1. EP - 2. JO - Pediatric Transplantation. JF - Pediatric Transplantation. SN - 1397-3142. IS - 1. ER - ...
BACKGROUND: The incidence and epidemiology of invasive fungal infections (IFIs), a leading cause of death among hematopoeitic stem cell transplant (HSCT) recipients, are derived mainly from single-institution retrospective studies. METHODS: The Transplant Associated Infections Surveillance Network, a network of 23 US transplant centers, prospectively enrolled HSCT recipients with proven and probable IFIs occurring between March 2001 and March 2006. We collected denominator data on all HSCTs preformed at each site and clinical, diagnostic, and outcome information for each IFI case. To estimate trends in IFI, we calculated the 12-month cumulative incidence among 9 sequential subcohorts. RESULTS: We identified 983 IFIs among 875 HSCT recipients. The median age of the patients was 49 years; 60% were male. Invasive aspergillosis (43%), invasive candidiasis (28%), and zygomycosis (8%) were the most common IFIs. Fifty-nine percent and 61% of IFIs were recognized within 60 days of neutropenia and ...
In a study reported in JAMA Oncology, Acuna et al found a nearly threefold increased risk of cancer mortality in solid-organ transplant recipients compared with the general population in Ontario, Canada.. Study Details. The population-based cohort study included data from 11,061 patients who underwent solid- organ transplantation in Ontario between 1991 and 2010, including 6,516 kidney, 2,606 liver, 929 heart, and 705 lung transplantations, representing 85,557 person-years of follow-up through December 2011. Recipients had a median age of 49 years, and 64% were male.. Increased Risk. Of 3,068 deaths in the cohort, 603 (20%) were cancer-related. Cancer mortality was significantly higher in transplant recipients than in the general population (standardized mortality ratio [SMR] = 2.84, 95% confidence interval [CI] = 2.61-3.07). Risk remained higher (SMR = 1.93, 95% CI = 1.75-2.13) in analysis, excluding patients with pretransplantation cancers (n = 1,124). Increased risk was observed for all types ...
Heart transplantation (HT) is an acceptable method of treating severe heart diseases in children when all other options have been exhausted. It is primarily intended for children suffering from cardiomyopathies, less often for children with severe arrhythmias and congenital heart defects. This method of treating children requires a multidisciplinary specialist cooperation and support in the childs home surroundings. Goal: The main goal is to present the development of Croatian paediatric transplantation cardiology. The secondary goal is to raise awareness of heart transplantations in children in order to motivate organ donations, it being the most limiting factor of the method. Results of study: The first heart transplantation in a child in Croatia was performed in 2011. Transplantation preparations were performed in eleven children. Two of the children died while on the waiting list, one child was removed from the waiting list due to recovery, and in eight of the children a transplantation was ...
Gras, Jeremie ; Latinne, Dominique ; Reding, Raymond ; Otte, Jean-Bernard ; Wieers, Grégoire ; et. al. IL-10 as a potential marker of graft acceptance in pediatric liver transplantation: Outcomes of a prospective immunologic monitoring in 40 recipients..In: Pediatric Transplantation, Vol. 9, p. 49-49 (2005 ...
article{3004d42f-c464-4188-bf60-ba0491925d72, author = {Bennhagen, Rolf and Sörnmo, Leif and Pahlm, Olle and Pesonen, Erkki}, issn = {1399-3046}, language = {eng}, number = {6}, pages = {773--779}, publisher = {Wiley-Blackwell}, series = {Pediatric Transplantation}, title = {Serial signal-averaged electrocardiography in children after cardiac transplantation.}, url = {}, volume = {9}, year = {2005 ...
Cell Markers include Diagnostic Immunophenotyping, Stem Cell Transplantation, and Immune Deficiency.. Diagnostic Immunophenotyping. We provide a comprehensive flow cytometry service for malignancy diagnosis and disease monitoring for the greater Auckland and Northland areas. The majority of our work involves leukaemia and lymphoma diagnosis in partnership with our Haematologists and Pathologists.. We also perform Immunocytochemical staining. We are involved with clinical trials for these patient populations. Samples processed include peripheral blood, bone marrow, CSF, FNAs, tissues and other body fluids.. Stem Cell Transplantation. Our laboratory is an integral part of the FACT accredited adult and paediatric Transplantation service for Auckland City Hospital and Starship hospital. We monitor CD34 levels and evaluate the quality of cells for transplantation on both fresh and post cyropreserved samples. Our service handles transplantation of mobilised stem cells, bone marrow and cord blood from ...
Dr. Gross was one of the most highly esteemed leaders in the field of hematology/oncology. Among his over 200 manuscripts were papers advancing our understanding of neonatal hematology, sickle cell disease, hemophilia, management of children with leukemia and neuroblastoma, and the use of bone marrow transplantation as a therapeutic modality for children with cancer. Dr. Grosss work in the areas of stem cell biology, Vitamin E and its role in hemolysis, clinical transplantation and the role of marrow purging in pediatric transplantation formed the basis of our current understanding of these areas. His work even resulted in a patent for a new Hematopoietic growth factor-Uteroferrin, derived from porcine uterus. Dr. Gross received an undergraduate degree in Biology and Chemistry at Bowdin College, a masters in Experimental Embryology at Amherst and his MD degree at University of Rochester. After a stint in the Marines during WWII, Dr. Gross began his career at Rainbow Childrens Hospital, Case ...
AFP February 1, 2016 - 50% of transplant-related deaths are due to immunosuppressive drugs, mostly infections - Most immunosuppressive drugs are metabolized via cytochrome P450 3A4 - so lots of interactions - Transplant recipients have increased risk of CAD and cardiovascular death HTN - goal (expert recommendation) is less than 130/80 mmHg - CCB reduce…
The American Society of Transplantation is dedicated to advancing the field of transplantation and improving patient care by promoting research, education, advocacy, organ donation, and service to the community.. ...
HIV Solid Organ Transplant Candidate/Recipient answers are found in the Johns Hopkins HIV Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Officials with the Department of Motor Vehicles teamed up with organ transplant recipients to encourage people to volunteer to become organ donors - when getting their drivers licenses.
Submit clotted, unspun red top tubes (preferred); serum is also acceptable.. Specimens must arrive within 2 hours of collection.. Copy of requisition MUST accompany specimen(s).. ...
The coronavirus pandemic has affected all areas of medical care, and a new study finds it has delayed potentially life-saving organ transplants.
Two short months free from an oxygen tank were enough time to complete what Charles W. Bud Groft Jr. wanted to do.Family members say the 51-year-old Manchester resident never regretted the
Transplant Research Review features key medical articles from global Transplant journals with commentary from ******. Covering topics such as bone marrow transplant, kidney transplant, liver transplant, heart transplant, transplantation, stem cell transplant, lung transplant, corneal transplant, organ transplant, bone marrow transplant, pancreas transplant, organ harvesting, islet cell transplant, allogeneic transplant, orthotopic heart transplant, organ rejection, intestine transplant, transplantation immunology, cadaveric renal transplant, orthotopic liver transplant, skin transplant, cord blood transplant, cell transplant, paediatric transplantation, bladder transplantation, ovarian transplant, transplant surgery complications, tissue transplant, transplantation ethics, transplantation medicine, autotransplantation, autograft, allotransplantation, allograft, isotransplantation, isograft, xenotransplantation, xenograft, domino transplantation, ABO-incompatible transplantation, regenerative medicine,
Three clusters of organ transplant-associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant-associated LCMV infections. Diabetic ketoacidosis developed in the organ donor in December 2010; she died with generalized brain edema after a short hospitalization. Both kidneys, liver, and lung were transplanted to 4 recipients; in all 4, severe posttransplant illness developed; 2 recipients died. Through multiple diagnostic methods, we identified LCMV infection in all persons, including in at least 1 sample from the donor and 4 recipients by reverse transcription PCR, and sequences of a 396-bp fragment of the large segment of the virus from all 5 persons were identical. In this cluster, all recipients developed severe illness, but 2 survived. LCMV infection should be considered as a possible cause of severe posttransplant illness ...
Post-transplant lymphoproliferative disorder (PTLD) is a heterogeneous group of lymphoid neoplasms associated with immunosuppression following solid organ transplantation or allogeneic hematopoietic stem cell transplantation. Mismatch...
Post-transplant lymphoproliferative disorder (PTLD) is a potentially life-threatening complication of immunosuppression and oncogenic viral infections.
After the cytomegalovirus vaccine Astellas licensed from Vical failed in a kidney transplant phase 2 study, hopes for the shot rested on a phase 3 trial in hematopoietic stem cell transplant recipients. But that hope has just been shattered too.
Legislation tackles disability-based discrimination of organ transplant recipients WASHINGTON, D.C. - U.S. Representatives Jaime Herrera Beutler (WA-03) and Katie Porter (CA-45) today reintroduced the Charlotte Woodward Organ Transplant Discrimination Prevention Act, which will prohibit using an individuals mental or physical disability as the sole basis of determining their eligibility for an organ transplant.. The bill, named after Charlotte Woodward, an advocate fighting against discrimination who has Down syndrome and received a heart transplant in 2012, clarifies that doctors, hospitals, transplant centers and other health care providers are prohibited from denying access to organ transplants solely based on a qualified individuals disability.. If an individual needs access to a life-saving organ transplant, they shouldnt be denied based on their disability - either physical or mental, Herrera Beutler said. Im proud to reintroduce this important legislation today named after ...
Solid Organ Transplant Recruiting Phase 2 Trials for Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated) (DB10791 ...
Browse top heart transplant surgeons. CPMC Heart and Vascular Center. San Francisco, CA. Among the best heart transplant doctors in the United States.
Washington [US], May 7 (ANI): Researchers at Johns Hopkins have found that two doses of a vaccine against SARS-CoV-2 -- the virus that causes COVID-19 -- confers some protection for people who have received solid organ transplants, its still not enough to enable them to dispense with COVID safety measures including masks and physical distancing.
Dr Anant Kumar, Indias most reputed kidney transplant surgeon for organ transplant & robotic surgery for kidney cancer, organ transplant etc.
Panacea Global Hair Services provides Best Hair Transplant in Jagadhri at a reasonable cost. We are one of the leading Clinics that have the team of Best Hair Transplant Surgeon in Jagadhri.
Last year, there were a record number of organ transplants in the country, and in Maryland. Experts believe the increase is in part due to the growing heroin epidemic.
At 61, Irene Schneider has undergone three kidney transplants, several bouts of dialysis and endured a lifetime of hospital visits.
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint ...
2 people had to die for me to still be here - Transplant recipient now transplant surgeon. Transplant recipient now transplant surgeon
TransMedics Group (NASDAQ:TMDX) is transforming the standard of care in solid organ transplants in order to increase the number of organ transplants and improve clinical outcomes.
With the advance of medicine and better understanding of everything related to transplantation, more patients live longer than ever after transplantation these days.
OMER said that patients will initially receive 12 weekly intravenous doses of the drug and additional weekly dosing can be administered for partial responders as well as relapsers. The primary endpoint of the treatment is a reduction in proteinuria at 24 weeks after the start of dosing. Of course, Omeros Corporation has been informed by the FDA that this primary endpoint could suffice for approval. In a statement, Gregory A. Demopulos, M.D., Chairman and CEO at OMER, had the following to offer:. Were pleased to have received agreement from FDA for our OMS721 Phase 3 protocol in IgA nephropathy… Final preparations to begin the trial can now be completed and enrollment is expected to open in early February. To our OMS721 Phase 3 programs in IgA nephropathy and aHUS, we have recently added a third Phase 3 program in stem cell transplant-associated TMA. We look forward to ongoing discussions with both the FDA and EMA regarding the HCT-TMA Phase 3 trial as well as breakthrough and PRIME ...
theodp writes The Commercial Appeal reports that Dr. James Eason, the surgeon who performed Steve Jobs liver transplant, found himself grilled at length Monday by Shelby County Commission members. The Univ. of Tennessee-Methodist Transplant Institute, which Eason heads, is in a bitter dispute over...
- No evidence of CMX001-associated kidney toxicity was seen in stem cell transplant recipients who were enrolled in a 230-patient Phase 2 study to evaluate CMX0
Giving Hope … Making Miracles. Transplant Financial Coordinators Association Conference October 22, 2009 San Diego, California. Childrens Organ Transplant Association ®. Mission. Slideshow 535441 by mayes
Surgeons in Sweden have performed the worlds first synthetic organ transplant - an artificial windpipe transplanted in a cancer patient.
Illegal organ transplants are on the rise as the gap between demand and supply widens- heres a look at what law can do to protect people.
Today there are more than 119,000 people waiting for organ transplants in the U.S. Only a small fraction of them will get the organs they need. Weve discovered its not just how sick you are, but where you live can determine whether you get a lifesaving organ or not.
2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ... Hand transplantation is a surgical procedure to transplant a hand from one human to another. The donor hand usually comes from ... On October 26, 2016, the Director of hand transplantation at UCLA, Dr. Kodi Azari, and his team, performed a hand transplant on ... There have been many advances in solid organ transplantation over the years that have made these medications quite tolerable. ...
"Uterus transplantation in the baboon: methodology and long-term function after auto-transplantation". Human Reproduction. 25 (8 ... Uterine transplantation starts with the uterus retrieval surgery on the donor. Working techniques for this exist for animals, ... In November 2017, the first baby was born after a uterus transplantation in the US. The birth occurred at Baylor University ... 2008). "Transplantation of the uterus in sheep: Methodology and early reperfusion events". Journal of Obstetrics and ...
The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: A 10-year update. J ... Heart transplantation is not considered to be a cure for heart disease; rather it is a life-saving treatment intended to ... Transplantation of the heart: An overview of 40 years' clinical and research experience at Groote Schuur Hospital and the ... Orthotopic heart transplantation: the bicaval technique Heart Treatments - Heart Treatments , NHLBI, NIH NIH (CS1 errors: ...
... is a surgical transplant procedure in which a penis is transplanted to a patient. The penis may be an ... Zhang, L. C.; Zhao, Y. B.; Hu, W. L. (2010). "Ethical issues in penile transplantation". Asian Journal of Andrology. 12 (6): ... A Preliminary Report of Penile Transplantation. Eur Urol 2006;50:851-3". European Urology. 51 (4): 1146-7. doi:10.1016/j.eururo ... The hospital that performed the first transplantation later issued a set of guidelines which, among other considerations, " ...
"High-risk Corneal Transplantation: Recent Developments and Future Possibilities". Transplantation. 103 (12): 2468-2478. doi: ... Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced ... Corneal transplantation is performed when medicines, keratoconus conservative surgery and cross-linking can no longer heal the ... Different types of contact lenses may be used to delay or eliminate the need for corneal transplantation in corneal disorders. ...
Thyroid transplantation became the model for a whole new therapeutic strategy: organ transplantation. After the example of the ... "ABO Incompatible Heart Transplantation in Young Infants". American Society of Transplantation. 30 July 2009. Archived from the ... Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era, edited by ... Previous efforts to create fair transplantation policies had focused on people currently on the transplantation waiting list. ...
... , or pulmonary transplantation, is a surgical procedure in which one or both lungs are replaced by lungs ... Wikimedia Commons has media related to Lung transplantation. MedlinePlus Encyclopedia: Lung transplantation United Network for ... Lung transplantation is the therapeutic measure of last resort for patients with end-stage lung disease who have exhausted all ... In deceased lobar transplantation, one donor can provide both lobes.[citation needed] Many patients can be helped by the ...
Advancement in immunosuppression has improved quality of life after transplantation. In most cases, pancreas transplantation is ... The majority of pancreas transplantations (> 90%) are simultaneous pancreas-kidney transplantations. Complications immediately ... One year after transplantation more than 95% of all patients are still alive and 80-85% of all pancreases are still functional ... This is the least performed method of pancreas transplantation and requires that only the pancreas of a donor is given to the ...
... is a form of organ transplantation where the thymus is moved from one body to another. It is used in ... "Transplantation tolerance and autoimmunity after xenogeneic thymus transplantation". J. Immunol. 166 (3): 1843-54. doi:10.4049/ ... Second, a thymus transplantation can cause a non-donor T cell-related GVHD because the recipients thymocytes would use the ... Thymus transplantation is used to treat infants with DiGeorge syndrome, which results in an absent or hypoplastic thymus, in ...
January 2011). "Graft-versus-host disease after intestinal and multivisceral transplantation". Transplantation. 91 (2): 219-224 ... Organ transplantation, Lymphatic organ surgery, Transplantation medicine, All stub articles, Medical treatment stubs). ... Spleen transplantation is the transfer of spleen or its fragments from one individual to another. It is under research for ... Spleen transplantation has been performed on humans with mixed results. Splenic tissue can be deliberately autotransplanted ...
Transplantation is a peer-reviewed medical journal covering transplantation medicine. The editor-in-chief is Jeremy R. Chapman ... Its sister journal, Transplantation Direct, is an online-only open access, peer-reviewed medical journal also covering ... "Transplantation". NLM Catalog. National Center for Biotechnology Information. Retrieved 2015-04-29. "Content overview". Scopus ... "Journals Ranked by Impact: Transplantation". 2020 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2020 ...
"A New Chapter for Cell Transplantation". Cell Transplantation. 26 (7): 1115. doi:10.1177/0963689717716682. ISSN 0963-6897. PMC ... Cell Transplantation is a monthly peer-reviewed medical journal covering regenerative medicine. It was established in 1992 and ...
... or hepatic transplantation is the replacement of a diseased liver with the healthy liver from another ... Before transplantation, liver-support therapy might be indicated (bridging-to-transplantation). Artificial liver support like ... A major advance in pediatric liver transplantation was the development of reduced size liver transplantation, in which a ... Although liver transplantation is the most effective treatment for many forms of end-stage liver disease, the tremendous ...
... is procedure whereby donated or laboratory-grown vagina tissue is used to create a 'neovagina'. It is ... An alternative to traditional reconstructive surgery is transplantation. In a handful of cases, a woman with vaginal aplasia ... Prapas; Papanicolaou; Prapas; Goutzioulis; Papanicolaou (1993). "Term pregnancy after vaginal transplantation in a case of ...
... (intestinal transplantation, or small bowel transplantation) is the surgical replacement of the small ... One of the rarest type of organ transplantation performed, intestine transplantation is becoming increasingly prevalent as a ... intestinal transplantations mostly approach survivorship rates of lung transplantation. At one-year, graft survival rates for ... "Intestine Transplantation in the United States, 1999-2008" (PDF). American Journal of Transplantation. 10 (4 Pt 2): 1020-34. ...
... is a monthly peer-reviewed medical journal covering pediatric transplantation. It is the official ... "Pediatric Transplantation". 2020 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2021. Official ... Organ transplantation journals, Wiley (publisher) academic journals, Pediatrics journals, Monthly journals, Publications ...
... is a peer-reviewed medical journal covering the field of organ transplantation. It is the official ... Transplantation Proceedings: Aims, accessed 2010-10-03 Official website v t e (Articles with short description, Short ... Organ transplantation journals, Academic journals associated with learned and professional societies, All stub articles, ...
Media related to Kidney transplantation at Wikimedia Commons Kidney transplantation at Curlie Kidney transplantation ( ... Previous efforts to create fair transplantation policies have focused on patients currently on the transplantation waiting list ... The Boston transplantation, performed on 23 December 1954 at Brigham Hospital, was performed by Joseph Murray, J. Hartwell ... Also, early post-transplantation renography is used for the assessment of delayed graft function. Kidney transplant recipients ...
... can also be used to restore eyelashes, eyebrows, beard hair, chest hair, pubic hair and to fill in scars ... Hair transplantation is a surgical technique that removes hair follicles from one part of the body, called the 'donor site', to ... Hair transplantation differs from skin grafting in that grafts contain almost all of the epidermis and dermis surrounding the ... Thus modern hair transplantation can achieve a natural appearance by mimicking original hair orientation. This hair transplant ...
Islet transplantation is the transplantation of isolated islets from a donor pancreas into another person. It is an ... "Strategic opportunities in clinical islet transplantation". Transplantation. 79 (10): 1304-7. doi:10.1097/01.TP. ... The goal of islet transplantation is to infuse enough islets to control the blood glucose level removing the need for insulin ... Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV (July 2000). "Islet transplantation in ...
It is the official publication of the Polish Transplantation Society with the co-operation of the Czech Transplantation Society ... Annals of Transplantation is a quarterly peer-reviewed medical journal that was established in 1996 and is published by ... "Annals of Transplantation". 2012 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2013. Official ... and the Hungarian Transplantation Society, and covers research on all aspects of organ transplantation. The journal is ...
ABO-incompatible (ABOi) transplantation is a method of allocation in organ transplantation that permits more efficient use of ... American Society of Transplantation. Retrieved from "ABO Incompatible Heart Transplantation in Young Infants , American Society ... 2007). Multicenter Experience of ABO-Incompatible Pediatric Cardiac Transplantation. American Journal of Transplantation, 0(0 ... Outcomes of ABO-incompatible kidney transplantation in the United States. Transplantation, 93(6), 603-609. doi:10.1097/TP. ...
In follicular unit transplantation, these small units allow the surgeon to safely transplant thousands of grafts in a single ... Follicular Unit Transplantation enables the hair transplant to look natural both at the individual follicular unit level and in ... Follicular unit transplantation (FUT) is a hair restoration technique, also known as the strip procedure, where a patient's ... Follicular unit transplantation uses follicular units to accomplish a number of objectives critical to the hair restoration ...
The Nephrology Dialysis Transplantation is a monthly peer-reviewed medical journal. It is published by Oxford University Press ... "Nephrology Dialysis Transplantation". 2021 Journal Citation Reports. Web of Science (Science ed.). Clarivate. 2022. ( ... Organ transplantation journals, All stub articles, Surgery journal stubs). ...
Summary of the British Transplantation Society UK Guidelines for Hepatitis E and Solid Organ Transplantation. Transplantation ... "History of the BTS - British Transplantation Society". "About the BTS - British Transplantation Society". ... Summary of the British Transplantation Society/Renal Association U.K. guidelines for living donor kidney transplantation. ... "Medawar Medal - British Transplantation Society". Retrieved 19 April 2018. "The Nobel Prize in Physiology or ...
Bone Marrow Transplantation is a peer-reviewed medical journal covering transplantation of bone marrow in humans. It is ... Bone Marrow Transplantation is abstracted and indexed in BIOBASE/Current Awareness in Biological Sciences, BIOSIS, Current ... "Bone Marrow Transplantation". 2020 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2021. Official ... The scope of the journal includes stem cell biology, transplantation immunology, translational research, and clinical results ...
"Transplantation" and sixth out of 200 journals in the category "Surgery". "Images in Transplantation". Wiley-Blackwell. doi: ... It covers research on all aspects of organ transplantation. Each issue offers continuing medical education in the form of its ... American Journal of Transplantation, Czech Edition. 3 (3). 2013.{{cite journal}}: CS1 maint: untitled periodical (link) " ... The American Journal of Transplantation is a monthly peer-reviewed medical journal published by Wiley-Blackwell on behalf of ...
Organ transplantation by country, Organ transplantation, Organ trade, Human rights abuses in China, Human rights of ethnic ... Peking University People's Hospital Liver Transplantation Center executed two cases of living related liver transplantation ... Organ transplantation in China has taken place since the 1960s, and is one of the largest organ transplant programmes in the ... HUMAN ORGAN TRANSPLANTATION - A Report on Developments Under the Auspices of WHO (1987-1991) Archived 21 October 2014 at the ...
... is the official journal of the Middle East Society for Organ Transplantation. The ... "Experimental and Clinical Transplantation". Retrieved 19 November 2019. Haberal, Mehmet; Masri, Marwan; Ghods, ... Experimental and Clinical Transplantation. 11 (1): 1-2. doi:10.6002/ect.2013.ecte1. PMID 23387535. Official website v t e ( ... Ahad J.; Rizvi, Sadibul Hasan; Shaheen, Faissal A. M. (February 2013). "Experimental and clinical transplantation: a commitment ...
Organ transplantation is a common theme in science fiction and horror fiction. Numerous horror movies feature the theme of ... Organ transplantation has also been used as a major plot element in a number of comedies, including Przekładaniec (1968, Poland ... The Thing with Two Heads (1972) and The Man With Two Brains (1983). Organ trade Organ transplantation in China, for a real- ... The Ethics of Human Organ Transplantation in Contemporary Film". Review of Education, Pedagogy, and Cultural Studies. 34 (3-4 ...
Table 4. Table 4. Contraindications to Lung Transplantation Absolute Contraindications for Organ Transplantation In General *. ... Heart-Lung Transplantation *. Pulmonary vascular diseases Primary pulmonary hypertension Eisenmengerss syndrome with cardiac ... Table 2. Table 2. Medical Conditions That Affect Eligibility for Lung Transplantation [42] *. Severe osteoporosis (eg, ... Those in the field of lung transplantation have certainly learned from the perils of early experiences. As with other types of ...
Organ Donation and Transplantation Statistics (National Kidney Foundation) * The SRTR/OPTN Annual Data Report (Scientific ... Organ Transplantation: Frequently Asked Questions (United Network for Organ Sharing) * Partnering with Your Transplant Team: ... Talking about Transplantation: What Every Patient Needs to Know (United Network for Organ Sharing) - PDF ... The Patients Guide to Transplantation (Health Resources and Services Administration; United Network for Organ Sharing) - PDF ...
Summary Table for Balamuthia Outbreaks Asociated with Organ Transplantation. Year(s). Donor. Transplant Recipients. Symptomatic ... Transmission of Balamuthia infection has occurred via organ transplantation from infected donors on three documented occasions ... Summary Table for Balamuthia Outbreaks Associated with Organ Transplantation in the United States. ...
... innovation, witnessing a CAGR of 3.70% - published on ... Bone Marrow Transplantation Market by Disease Indication. Leukemia. Lymphoma. Myeloma. Others. Bone Marrow Transplantation ... Bone Marrow Transplantation Market Categorization. Bone Marrow Transplantation Market by End User. Hospitals. Multispecialty ... The Bone Marrow Transplantation Market to foray into digital innovation, witnessing a CAGR of 3.70%. 11-25-2022 09:53 PM CET , ...
Massive reflux is an indication for pre-transplantation nephroureterectomy. Reconstructive o … ... Of patients undergoing renal transplantation during a recent 18-month period 42 per cent had significant urologic abnormalities ... Renal transplantation in patients with urologic abnormalities J Urol. 1976 May;115(5):490-3. doi: 10.1016/s0022-5347(17)59252-6 ... Patients with a variety of abnormalities of the urinary tract had a transplantation success rate comparable to that of azotemic ...
2009)‎. Human organ and tissue transplantation. World Health Organization. ...
... N Engl J Med. 1999 Apr 8;340(14):1081-91. doi: 10.1056/NEJM199904083401406. ...
Browse the archive of articles on Bone Marrow Transplantation ... Bone Marrow Transplantation (Bone Marrow Transplant) ISSN 1476- ... Malaria infection after allogeneic bone marrow transplantation in a child with thalassemia *V-B Tran ... Generation of normal lymphocyte populations following transplantation of adenosine-deaminase-deficient fetal liver cells *AAJ ... European results of matched unrelated donor bone marrow transplantation for chronic myeloid leukemia. Impact of HLA class II ...
Research into the possibility of liver transplantation (LT) started before the 1960s with the pivotal baseline work of Thomas ... Self-organizing maps can determine outcome and match recipients and donors at orthotopic liver transplantation. Transplantation ... Acute-on-Chronic Liver Failure Before Liver Transplantation: Impact on Posttransplant Outcomes. Transplantation. 2011 Oct 27. ... Antonios Arvelakis, MD, MPH Associate Professor of Surgery (Transplantation), Recanati/Miller Transplantation Institute, The ...
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UNOS and the Organ Donation and Transplantation Alliance credited the organ donation and transplantation community,… ... The agency will accept comments until May 9 on ways to improve the Organ Procurement and Transplantation Network. ... Service has updated its 2020 recommendations for reducing HIV and hepatitis B and C transmission through organ transplantation. ...
Transplantation. News, opinions and meeting coverage in transplantation.. See All in Transplantation. *Heart Transplantation ... More in Transplantation. BP Control Beneficial for Liver Transplant Recipients. Patients who kept their blood pressure under ... Latest in Transplantation. COVID Vaccine Mandates in the Spotlight at the AMAs Interim Meeting ...
encoded search term (Hair Transplantation) and Hair Transplantation What to Read Next on Medscape ... Hair Transplantation Workup. Updated: Jul 28, 2022 * Author: Jeffrey S Epstein, MD, FACS; Chief Editor: Arlen D Meyers, MD, MBA ... Hair Transplantation Techniques for the Transgender Patient. Facial Plast Surg Clin North Am. 2019 May. 27 (2):227-232. [QxMD ... Hair transplantation for the treatment of lichen planopilaris and frontal fibrosing alopecia: A report of two cases. Australas ...
Making an equal system equitable: Proposing a sex-adjusted MELDNa score for liver transplantation allocation Julia M. Sealock, ... A functional TGFB1 polymorphism in the donor associates with long-term graft survival after kidney transplantation Felix ...
An animal study finds success with fecal stool transplantation against multidrug-resistant Klebsiella pneumoniae and vancomycin ... Fecal transplantation from healthy human donors has so far been found to be particularly effective for treating Clostridium ... It is known that transplantation of feces from healthy mice can eliminate VRE from the intestine of densely colonized mice, say ... In this test of whether fecal transplantation can clear K. pneumoniae and concurrent infections with both the pathogens, the ...
Drs Sudhir Kushwaha and Rocky Daly-respectively the medical and surgical directors of the Heart Transplantation and VAD therapy ... Which patients are the best candidates for heart transplantation? ... Which patients are the best candidates for heart transplantation Drs Sudhir Kushwaha and Richard (Rocky) Daly respectively the ... Cite this: #27: Heart transplantation: Selecting the ideal candidate - Medscape - Mar 14, 2013. ...
Advanced Heart Failure and Transplantation Fellowship. Overview. The Stollery Childrens Hospital is currently the institution ... The service for end stage heart failure and transplantation with standardized protocols and performing cutting-edge procedures ... The position will include clinical responsibilities for the in-patients and out-patients before and after transplantation, ... averaging between 10 to 20 heart transplantations per year. The Department of Pediatrics host one of the largest pediatric ...
Transplantation 2015;99:2174-80.. *Al-Adra DP, Gill RS, Imes S, et al. Single-donor islet transplantation and long-term insulin ... Transplantation 2007;84:541-4.. *Lindahl JP, Jenssen T, Hartmann A. Long-term outcomes after organ transplantation in diabetic ... 4. Pancreas Transplantation. Pancreas transplantation can result in complete independence from exogenous insulin in the ... Transplantation 2003;76:974-6.. *Larsen JL, Colling CW, Ratanasuwan T, et al. Pancreas transplantation improves vascular ...
... You may be trying to access this site from a secured browser on the server. Please ... First, in the rapidly advancing era of ex vivo lung perfusion, it will be highly relevant in clinical lung transplantation to ... In this study, Querrey et al2 investigated the signals that regulate neutrophil chemotaxis during lung transplantation. The ... The importance of this TLR agonist was further supported by its elevated serum levels after lung transplantation in human ...
2009)‎. Human organ and tissue transplantation. World Health Organization. ...
... of combining pembrolizumab immunotherapy with standard chemotherapy drugs and autologous stem cell transplantation (ASCT) in ... A Phase II Study of Pembrolizumab Immunotherapy plus Chemotherapy followed by Autologous Stem Cell Transplantation for ... of combining pembrolizumab immunotherapy with standard chemotherapy drugs and autologous stem cell transplantation (ASCT) in ...
Caution about the use of everolimus immediately after transplantation should be exercised in certain patients with the risk of ... everolimus should be initiated as soon as possible after heart transplantation. Immediate and adequate reduction of CNI ... The evidence base relating to the use of everolimus in heart transplantation has expanded considerably in recent years, ... Everolimus in Heart Transplantation: An Update. Stephan W. Hirt. ,1Christoph Bara. ,2Markus J. Barten. ,3Tobias Deuse. ,4 ...
When you support the Center for Transplantation Sciences (CTS), you are making a significant impact to advancing patient care, ... Support the Center for Transplantation Sciences. When you support the Center for Transplantation Sciences (CTS), you are making ... Make a Difference for the Center for Transplantation Sciences. When you support the Center for Transplantation Sciences, you ...
Transplantation is often used to treat end-stage kidney disease. Diabetes is the most common cause of kidney and pancreas ... transplantation.. People with either acute or chronic liver failure may need a liver transplant to survive. Most often, chronic ...
Call us at 443-997-1583 to learn more about penile transplantation. ...
Allogeneic Stem Cell Transplantation. This is the most common type of stem cell transplantation used to treat AML. Allogeneic ... The two main types of stem cell transplantation are *Allogeneic stem cell transplantation, using stem cells from a matched or ... Reduced-Intensity Allogeneic Stem Cell Transplantation. This type of transplantation may be a treatment option for older ... Autologous Stem Cell Transplantation. This is a procedure in which bone marrow is removed from a patient after achieving a ...
stem cell transplantation Clinical Research Trial Listings on CenterWatch ... TLI, TBI, ATG & Hematopoietic Stem Cell Transplantation and Recipient T Regs Therapy in Living Donor Kidney Transplantation ... transplantation. (allo-. HSCT. ) is a potentially curative therapy for many malignant or nonmalignant hematological diseases. ... Hematologic transplantation (. HCT. ) is a common treatment for these cancers, but often leads to ...
Also avail free - Bone Marrow Transplantation News Widget from Medindia ... Find latest news and research updates on Bone Marrow Transplantation. ... About , Types of Bone Marrow Transplantation , Indications for Bone Marrow Transplantation , Complications of Bone Marrow ... Bone Marrow Transplantation. Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are ...
Tags: Health Insurance, Hospital, Liver, Liver Disease, Liver Transplant, Liver Transplantation, Medicaid, Poverty, Primary ... Zarrinpar, A., et al. (2021) Racial Disparities in Liver Transplantation Listing. Journal of the American College of Surgeons. ... Patients need to be made aware earlier on that transplantation is a potential solution for certain liver conditions. If aware, ... Further, the longer amount of time people traveled to that center for liver transplantation, the less the center was ...

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