Time Factors: Elements of limited time intervals, contributing to particular results or situations.Protein Sorting Signals: Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Railroads: Permanent roads having a line of rails fixed to ties and laid to gage, usually on a leveled or graded ballasted roadbed and providing a track for freight cars, passenger cars, and other rolling stock. Cars are designed to be drawn by locomotives or sometimes propelled by self-contained motors. (From Webster's 3d) The concept includes the organizational and administrative aspects of railroads as well.Signal Processing, Computer-Assisted: Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.Action Potentials: Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Models, Neurological: Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Nuclear Localization Signals: Short, predominantly basic amino acid sequences identified as nuclear import signals for some proteins. These sequences are believed to interact with specific receptors at the NUCLEAR PORE.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Synaptic Transmission: The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Synapses: Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Excitatory Postsynaptic Potentials: Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Signal Detection, Psychological: Psychophysical technique that permits the estimation of the bias of the observer as well as detectability of the signal (i.e., stimulus) in any sensory modality. (From APA, Thesaurus of Psychological Index Terms, 8th ed.)Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Reaction Time: The time from the onset of a stimulus until a response is observed.Acoustic Stimulation: Use of sound to elicit a response in the nervous system.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Animal Communication: Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Cochlear Nerve: The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Evoked Potentials: Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.Calcium Signaling: Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Neural Inhibition: The function of opposing or restraining the excitation of neurons or their target excitable cells.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Photic Stimulation: Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesKinetics: The rate dynamics in chemical or physical systems.Nonlinear Dynamics: The study of systems which respond disproportionately (nonlinearly) to initial conditions or perturbing stimuli. Nonlinear systems may exhibit "chaos" which is classically characterized as sensitive dependence on initial conditions. Chaotic systems, while distinguished from more ordered periodic systems, are not random. When their behavior over time is appropriately displayed (in "phase space"), constraints are evident which are described by "strange attractors". Phase space representations of chaotic systems, or strange attractors, usually reveal fractal (FRACTALS) self-similarity across time scales. Natural, including biological, systems often display nonlinear dynamics and chaos.Patch-Clamp Techniques: An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Neural Networks (Computer): A computer architecture, implementable in either hardware or software, modeled after biological neural networks. Like the biological system in which the processing capability is a result of the interconnection strengths between arrays of nonlinear processing nodes, computerized neural networks, often called perceptrons or multilayer connectionist models, consist of neuron-like units. A homogeneous group of units makes up a layer. These networks are good at pattern recognition. They are adaptive, performing tasks by example, and thus are better for decision-making than are linear learning machines or cluster analysis. They do not require explicit programming.Nuclear Export Signals: Specific amino acid sequences present in the primary amino acid sequence of proteins which mediate their export from the CELL NUCLEUS. They are rich in hydrophobic residues, such as LEUCINE and ISOLEUCINE.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Auditory Perception: The process whereby auditory stimuli are selected, organized, and interpreted by the organism.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Nerve Net: A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Neuronal Plasticity: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.Protein Transport: The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.Bacterial Proteins: Proteins found in any species of bacterium.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Microelectrodes: Electrodes with an extremely small tip, used in a voltage clamp or other apparatus to stimulate or record bioelectric potentials of single cells intracellularly or extracellularly. (Dorland, 28th ed)Pyramidal Cells: Projection neurons in the CEREBRAL CORTEX and the HIPPOCAMPUS. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region.Motor Neurons: Neurons which activate MUSCLE CELLS.Mice, Inbred C57BLReproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Hippocampus: A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.Psychoacoustics: The science pertaining to the interrelationship of psychologic phenomena and the individual's response to the physical properties of sound.Artifacts: Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Auditory Pathways: NEURAL PATHWAYS and connections within the CENTRAL NERVOUS SYSTEM, beginning at the hair cells of the ORGAN OF CORTI, continuing along the eighth cranial nerve, and terminating at the AUDITORY CORTEX.Neurons, Afferent: Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.Neurophysiology: The scientific discipline concerned with the physiology of the nervous system.STAT3 Transcription Factor: A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Electromyography: Recording of the changes in electric potential of muscle by means of surface or needle electrodes.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Neural Pathways: Neural tracts connecting one part of the nervous system with another.Brain Mapping: Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.Neurotransmitter Agents: Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Presynaptic Terminals: The distal terminations of axons which are specialized for the release of neurotransmitters. Also included are varicosities along the course of axons which have similar specializations and also release transmitters. Presynaptic terminals in both the central and peripheral nervous systems are included.Cytoplasm: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Auditory Threshold: The audibility limit of discriminating sound intensity and pitch.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Normal Distribution: Continuous frequency distribution of infinite range. Its properties are as follows: 1, continuous, symmetrical distribution with both tails extending to infinity; 2, arithmetic mean, mode, and median identical; and 3, shape completely determined by the mean and standard deviation.Afferent Pathways: Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Neuromuscular Junction: The synapse between a neuron and a muscle.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Cochlear Implants: Electronic hearing devices typically used for patients with normal outer and middle ear function, but defective inner ear function. In the COCHLEA, the hair cells (HAIR CELLS, VESTIBULAR) may be absent or damaged but there are residual nerve fibers. The device electrically stimulates the COCHLEAR NERVE to create sound sensation.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Vocalization, Animal: Sounds used in animal communication.Loudness Perception: The perceived attribute of a sound which corresponds to the physical attribute of intensity.Periodicity: The tendency of a phenomenon to recur at regular intervals; in biological systems, the recurrence of certain activities (including hormonal, cellular, neural) may be annual, seasonal, monthly, daily, or more frequently (ultradian).Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Nerve Fibers: Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.Movement: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Protein Processing, Post-Translational: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Sound Spectrography: The graphic registration of the frequency and intensity of sounds, such as speech, infant crying, and animal vocalizations.Long-Term Potentiation: A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.Green Fluorescent Proteins: Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Interneurons: Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.Adaptation, Physiological: The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.COS Cells: CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)Auditory Cortex: The region of the cerebral cortex that receives the auditory radiation from the MEDIAL GENICULATE BODY.Mitogen-Activated Protein Kinases: A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).Electroencephalography: Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.Cerebral Cortex: The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Visual Cortex: Area of the OCCIPITAL LOBE concerned with the processing of visual information relayed via VISUAL PATHWAYS.Protein-Serine-Threonine Kinases: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.Brain Stem: The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.Electric Fish: Fishes which generate an electric discharge. The voltage of the discharge varies from weak to strong in various groups of fish. The ELECTRIC ORGAN and electroplax are of prime interest in this group. They occur in more than one family.Feedback: A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.Dendrites: Extensions of the nerve cell body. They are short and branched and receive stimuli from other NEURONS.Receptors, Cell Surface: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.Macaca mulatta: A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.Electrodes: Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.Differential Threshold: The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Excitatory Amino Acid Antagonists: Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Noise: Any sound which is unwanted or interferes with HEARING other sounds.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Sensory Receptor Cells: Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.Poisson Distribution: A distribution function used to describe the occurrence of rare events or to describe the sampling distribution of isolated counts in a continuum of time or space.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Active Transport, Cell Nucleus: Gated transport mechanisms by which proteins or RNA are moved across the NUCLEAR MEMBRANE.Image Enhancement: Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.Cues: Signals for an action; that specific portion of a perceptual field or pattern of stimuli to which a subject has learned to respond.Microscopy, Confocal: A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.Visual Pathways: Set of cell bodies and nerve fibers conducting impulses from the eyes to the cerebral cortex. It includes the RETINA; OPTIC NERVE; optic tract; and geniculocalcarine tract.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Gymnotiformes: An order of neotropical electric fish found chiefly in the waters of South America. They continually emit weak electric discharges, which they use in object location and communication. A most popular species of research interest is the electric eel, ELECTROPHORUS electricus.Endoplasmic Reticulum: A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)Physical Stimulation: Act of eliciting a response from a person or organism through physical contact.Animals, Newborn: Refers to animals in the period of time just after birth.Information Theory: An interdisciplinary study dealing with the transmission of messages or signals, or the communication of information. Information theory does not directly deal with meaning or content, but with physical representations that have meaning or content. It overlaps considerably with communication theory and CYBERNETICS.Feedback, Physiological: A mechanism of communication with a physiological system for homeostasis, adaptation, etc. Physiological feedback is mediated through extensive feedback mechanisms that use physiological cues as feedback loop signals to control other systems.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Amino Acid Motifs: Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.Somatosensory Cortex: Area of the parietal lobe concerned with receiving sensations such as movement, pain, pressure, position, temperature, touch, and vibration. It lies posterior to the central sulcus.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Electrophysiological Phenomena: The electrical properties, characteristics of living organisms, and the processes of organisms or their parts that are involved in generating and responding to electrical charges.Axons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Acoustics: The branch of physics that deals with sound and sound waves. In medicine it is often applied in procedures in speech and hearing studies. With regard to the environment, it refers to the characteristics of a room, auditorium, theatre, building, etc. that determines the audibility or fidelity of sounds in it. (From Random House Unabridged Dictionary, 2d ed)Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
"Disused Stations - Rainford Junction Signal Box" Disused Stations; Retrieved 25 March 2016 "Fazakerley train station , ... timetable posters and shelters on each side; a P.A system also provides automated train running information. The ticket office ... During Monday to Saturday daytimes, there are trains every 15 minutes between Kirkby and Liverpool Central. In the evenings and ... Table 104 National Rail timetable, December 2016 Butt, R. V. J. (1995). The Directory of Railway Stations: details every public ...
Most trains used continue to Rochdale prior to the December 2008 timetable change, but more recently ran to/from Stalybridge. ... "Disused Stations - Liverpool ExchangeDisused Stations; Retrieved 25 March 2016 "Disused Stations - Rainford Junction Signal ... Table 104 National Rail timetable, December 2016 Northern Timetable 14 - Manchester and Manchester Airport to Southport and ... Trains from Manchester normally start at Victoria, though one runs through from Buxton in the morning peak. The last departure ...
"Birkdale train station , timetable , ticket prices & facilities". www.merseyrail.org. Retrieved 6 February 2017. Awdry, ... Birkdale is the only station on the line that still has a signal box.[citation needed] The station is staffed, during all ... Trains operate every 15 minutes throughout the day from Monday to Saturday and on summer Sundays to Southport to the north, and ... The disused signal box. Birkdale Station entrance, in 1964. Harrop 1985, pp. 136 & 144. Bradshaw 1968, p. 756. The first ...
Train running information is offered via CIS displays, timetable posters and automatic announcements. Level access to both ... An Arriva Trains Wales Class 158 waits at platform 1 Gobowen North signal box is opposite the station, across the level ... train services run on two routes; Arriva Trains Wales service from Birmingham International to Holyhead. Arriva Trains Wales ... one of which connects with the Virgin Trains West Coast service to London Euston), whilst one morning & one evening train start ...
Six trains call in each direction Mon-Sat, with three departures each way on Sundays from the beginning of the summer timetable ... "Signalling over Wales" Roberts, A www.6g.nwrail.org.uk; Retrieved 31 May 2017 Slater, J.N., ed. (July 1974). "Notes and News: ... Digital CIS displays, a pay phone and timetable poster boards are provided to offer train running information. The station has ... Conwy Valley Railway Train times and station information for Tal-y-Cafn railway station from National Rail Coordinates: 53°13′ ...
"New timetables from Sunday June 21 - Geelong" (Press release). Geelong: V/Line. n.d. Retrieved 2015-06-24. "Extra train service ... These upgrades include new signalling, level crossing upgrades and a crossing loop at Boorcan, near Camperdown. Bold stations ... so that three Sunday train services run in both directions instead of two. Following a timetable change on 27 August 2017, ... V/Line operates four daily passenger trains in each direction, with three services on weekends and public holidays. Trains ...
Special signalling is required at the station, both to recognise the division of the outbound train as intentional, and to ... This dual service ended with the new transport timetable introduced in December 2017. Now, separate trains are used for each ... A dividing train is a train that separates into two trains partway along its route, so as to serve two destinations. On the ... A second train is then formed from the detached cars, the points are changed at the junction, and a new crew drives the train ...
Signals which correctly protect the train and permit complex timetabled operations. Multi-user mode in which any timetabled ... Microsoft Train Simulator (abbreviated to MSTS) is a train simulator for Microsoft Windows, released in May 2001 and developed ... Train simulator - reference article to other train simulator products. Other games from the Simulator series: Microsoft Flight ... "Microsoft Train Simulator Review for PC". GameFAQs. Retrieved January 20, 2009. "Train Simulator 2 Impressions - PC News at ...
Train running information is offered via CIS display screens, customer help points and timetable poster boards. Step-free ... The signal box's Network Rail designation was "WM". It is unstaffed, but does have a self-service ticket machine available for ... with six trains southbound and five northbound on Sundays. The latter are nearly all long distance trains between Manchester ... Train times and station information for Wem railway station from National Rail Coordinates: 52°51′23″N 2°43′05″W / 52.8564°N ...
Train times and station information for Swinderby railway station from National Rail http://www.derby-signalling.org.uk/Newark. ... Table 27 National Rail timetable, May 2017 ... train operating company (TOC) who provide all services. The ... The full range of tickets for travel are purchased from the guard on the train at no extra cost. There are no retail facilities ... A few Lincoln to Newark North Gate trains also call. The Sunday service is infrequent in the morning and early afternoon, but ...
"Shildon Signal Box". Historic England. Table 44 National Rail timetable, December 2017 Train times and station information for ... The station is unstaffed and all tickets must be purchased on the train or prior to travel, as there are no ticketing ... The station is on the Tees Valley Line and is operated by Northern, which provides all passenger train services. The station is ... The grade II listed manual signal box here controls the immediate station area (including the siding connections into the ...
"End of an era as signal box goes". Solihull News. Retrieved 10 January 2016. Table 71 National Rail timetable, May 2016 Train ... Situated on the North Warwickshire Line, the station, and all trains serving it, are operated by West Midlands Trains. The ... with some trains continuing onward to Kidderminster and Worcester. 3 trains per hour southbound to Whitlocks End, one of which ... During Monday to Saturday daytimes: 3 trains per hour northbound to Birmingham Moor Street and Birmingham Snow Hill continuing ...
50 Minute Timetable; 1 train. Green (weekends and bank holidays): 30 Minute Timetable; 2 trains. Red (gala days and some ... museum and the Signal Box Inn 'The Smallest Pub on the Planet'. Humberston North Sea Lane: Opened in 2007, features a signal ... Trains run from Kingsway station, which is next to the Leisure Centre, over a 40 yards (37 m) viaduct and along the sea wall, ... special events): 15 Minute Timetable; 4 trains. The railway is operated by a fleet of seven steam locomotives and five diesel ...
As from 7 April 1914 golfers could halt a train by operation of a signal provided. It was to be "held at 'Danger' by passengers ... Croughton and others Table 100 National Rail timetable, December 2016 Train times and station information for St Bees railway ... formerly being noted for having warning of the approaching trains rung through from the signal box in the evening. The beach, ... The first train of coal wagons on this day (dies cinerum) ["Day of Ashes"] went on the railway to Braystones". Despite ...
T6 Carlingford line timetable Sydney Trains 20 October 2013 http://www.transport.nsw.gov.au/media-releases/making-it-happen- ... "NSW Track and Signalling Diagrams", Australian Railway Historical Society (NSW Division) "NSW Railway Passenger Services 1880- ... All other stations on the Sydney Trains network are capable of accommodating eight-car trains. There are no crossing loops or ... "Train Operating Conditions (TOC) Manual - Track Diagrams (version 3.0)" (PDF). "Train Patronage - Monthly Figures". Transport ...
... to part-fund re-signalling work needed at Worgret Junction to provide a more regular service. The first timetabled trains ... However all regular timetabled trains continued to terminate at Norden, with only occasional excursion trains running between ... where they connect with trains on the London Waterloo to Weymouth service. The trains that continue to Wareham are always ... The level of service varies from 4 to 16 trains a day in each direction, depending the season and the day of the week. On 60 ...
Many other trains, including two northbound and one southbound local trains per day, pass through the station. The station ... ISBN 4-533-02980-9. JTB Timetable No. 998 (March 2009). Tokyo: JTB Corporation. pp. 654-667. 廃止の10無人駅 思い出の駅舎さようなら 住民ら幕掲げ感謝 [10 ... began operation as Higashiyama Signal Box (東山信号場, Higashiyama Shingōjō) on February 26, 1943. On August 1, 1949, it became ... The station was numbered "H64". According to the timetable of March 2009, the station
An emergency timetable was in operation, with all trains replaced by buses between Armathwaite (or in certain cases Appleby) ... as single-line working was in force from Kirkby Thore signal box (north of Appleby) to the temporary terminus at Armathwaite. ... so tickets have to be bought in advance or on the train. Train running information is available via information boards & ... It is operated by Northern who provide all passenger train services. The station was opened by the Midland Railway on 1 May ...
Sunday trains only operate during the summer months (May timetable change until mid-September) - these operate only as a ... The station retains its signal box and semaphore signalling. The station buildings have been demolished and replaced by small ... Train running information is offered via timetable posters and telephone. Step-free access to both platforms is available, ... Train times and station information for Deganwy railway station from National Rail Coordinates: 53°17′42″N 3°49′59″W / 53.295 ...
Train running information is offered via customer help points, CIS displays, automatic announcements and timetable posters. ... It has retained its signal box, which has been refurbished and controls the passing loop and level crossing here. As noted, the ... The initial passenger service took 2 hours, with 3 trains a day, calling at all stations. Only mail trains ran on Sundays. The ... The track was doubled in 1896, when a non-stop train from Aberdeen was speeded up to a 45-minute schedule for the 40 3⁄4 mi ( ...
Timetable information posters and a telephone link are available to give train running information, but there are no ticket- ... The Armathwaite signal box was built by the Midland Railway and placed in service on 16 July 1899. It was equipped with a 16- ... An emergency timetable was in operation, with trains from Leeds terminating/starting here and a rail replacement bus link ... Six trains each way serve the station Mondays to Saturdays, with three trains each way calling on Sundays (increasing to five ...
... scheduling train timetables, and management of railway property, such as lines and stations. A company of PKP Group, ... It is used for power supply of signals, level crossing equipment and other devices requiring electric power used for the rail. ... fast trains on international routes with both 1st and 2nd class). For domestic routes InterRegio and RegioEkspres trains share ... Pendolino high-speed trains EuroCity (EC): International trains which operate major routes and require reservation Express ...
There are Regional-Express and Regionalbahn trains serving the station with a regular interval timetable, additionally, one ... German for train dispatcher), at the northern end of the station. This signal box also controls the station of Kohlscheid, ... The Hf signal box then was also responsible for the routes to Heerlen and Alsdorf. All lines leaving Aachen in northern ... The fourth one, track 55, is a dead end for trains to and from Alsdorf. Formerly, next to this track, other terminal tracks ...
Train running information can be obtained from timetable posters or by phone from the station signal box. A bus service to & ... The signal box (opened just a few months before the Christmas 1910 accident) on the northbound platform is still in use today. ... It is operated by Northern who provide all passenger train services; it is situated 61 1⁄2 miles (99 km) north of Leeds. The ... The station is also served by DalesRail trains between Blackpool North/Preston and Carlisle on Sundays during the summer (one ...
This was completed on 24 March 2013, and new timetable changes have resulted in a morning train reaching Derry before 9am for ... the signalling and level crossings are controlled by the Coleraine signal cabin. Following the signalling upgrade in 2016, the ... After passing through a short opening trains pass through the shorter Downhill tunnel which is 301 yards in length. Signalling ... The whole of the Belfast to Londonderry line is now controlled by colour light signals, the last semaphore signals at ...
The infamous 'Gate of Death' at Auschwitz II for the incoming freight trains was built of brick and cement mortar in 1943, and ... They constructed and published timetables, collected fares, and allocated cars and locomotives. In sending Jews to their death ... signaling the beginning of the 'Final Solution'."[54] About 80,000 Jews were killed in Lithuania by October (including in ... Bureaucrats in the Reichsbahn performed important functions that facilitated the movement of trains. ...
"Disused Stations - Rainford Junction Signal Box" Disused Stations; Retrieved 25 March 2016 "Fazakerley train station , ... timetable posters and shelters on each side; a P.A system also provides automated train running information. The ticket office ... During Monday to Saturday daytimes, there are trains every 15 minutes between Kirkby and Liverpool Central. In the evenings and ... Table 104 National Rail timetable, December 2016 Butt, R. V. J. (1995). The Directory of Railway Stations: details every public ...
Most trains used continue to Rochdale prior to the December 2008 timetable change, but more recently ran to/from Stalybridge. ... "Disused Stations - Liverpool ExchangeDisused Stations; Retrieved 25 March 2016 "Disused Stations - Rainford Junction Signal ... Table 104 National Rail timetable, December 2016 Northern Timetable 14 - Manchester and Manchester Airport to Southport and ... Trains from Manchester normally start at Victoria, though one runs through from Buxton in the morning peak. The last departure ...
... to part-fund re-signalling work needed at Worgret Junction to provide a more regular service. The first timetabled trains ... However all regular timetabled trains continued to terminate at Norden, with only occasional excursion trains running between ... where they connect with trains on the London Waterloo to Weymouth service. The trains that continue to Wareham are always ... The level of service varies from 4 to 16 trains a day in each direction, depending the season and the day of the week. On 60 ...
Automatically generate train timetable based on number of trains, head-way, dwell time, etc. ... Transient Stability (TS) to User-Defined Dynamic Model (UDM) network control signal types ... Import train schedule from Excel format for faster data entry. Results & Plots. *Graphical plots using Plot Manager *Rail ... Auto-gap, working distance & auto-selection of minimum approach distance per NESC C2 2012/2017 ...
Automatically generate train timetable based on number of trains, head-way, dwell time, etc. ... Transient Stability (TS) to User-Defined Dynamic Model (UDM) network control signal types ... Import train schedule from Excel format for faster data entry. Results & Plots. *Graphical plots using Plot Manager *Rail ... Auto-gap, working distance & auto-selection of minimum approach distance per NESC C2 2012/2017 ...
... a commercial train simulator that lets you operate and route trains to their destination. ... Experience railway signalling/dispatching control centres through SimSig, ... In layman terms, trains with Invalid Timetables in SimSig throw all sorts of Wobblies because the train doesnt really know ... This timetable was written using the paged version of the sim.. Barry Barry, Sydney, New South Wales, Australia Log in to reply ...
... a commercial train simulator that lets you operate and route trains to their destination. ... Experience railway signalling/dispatching control centres through SimSig, ... In layman terms, trains with Invalid Timetables in SimSig throw all sorts of Wobblies because the train doesnt really know ... Arriva Trains Mash Up (NWC/NE Wales/Chester/Cheshire lines) 26/09/2020 at 18:00 elltrain3 (12 users signed up) ...
The train timetable during holidays for domestic trains became valid on weekdays as well. Minnesota public school district ... cell death via one of the last steps in the apoptosis pathway in which complexes containing intracellular apoptosis signalling ... It was first held in 2017, and buy real chloroquine bars online is held alongside the Ivy womens tournament, also introduced ... in 2017, at the same venue. FNC maintains an archive of most of its programs. ...
At peak hour there are 8 trains per hour, but this reduces to 4/5 tph as a base timetable. ... Ansaldo will supply CBTC signalling, telecoms, power supplies, platform screen doors, automatic fare collection system, SCADA ... so that trains will run through to Taipei serving all stations (every 15 min), while Airport Express trains will call every 15 ... 02 March 2017: Airport MRT Taipei Main Station - Huanbei In 2004, Taiwan introduced the commonly used transliteration of ...
A shore-based system called Automatic Train Regulation (ATR) holds the geographic route map of the core and the base timetable ... the train will come to rest at the signal prior to the transition point of ETCS boundary so the train can never leave the ETCS ... using European Train Control System (ETCS) Level 2. In-cab signalling is required to allow trains to be driven automatically ... 86 trains an hour!. A fundamental pre-requisite of ERTMS Level 2 is a fixed-block system with signal interlocking. The core was ...
View ane and over scribbles or koyna express pune to mumbai timetable sheet 2017 profane migrated harmful. Magnified Plato flew ... anagrammatize adscititious signals twenty times? Mauricio cavorts unfinished, their selfish snashes allows deprecatorily. ... Magnified Plato flew over their sealed trains appeasingly? peatier Mickey put his thig syncopator riposting bimanual. effable ... Magnified Plato flew over their sealed trains appeasingly? geometric shapes worksheets 2nd grade unblotted vowing that washes ...
During the deepest throes of sleep, the bodys support systems run on their own timetables. Nerve cells hum along in your brain ... their chitchat generating slow waves that signal sleeps nether stages. Yet, like buses and trains with... ... 08/09/2017 - 11:00 Animals, Science & Society * Feature Organisms age in myriad ways - and some might not even bother The scene ...
The timetable for withdrawal continues to stretch into the future. It is also highly unlikely that SOCOM will reduce its global ... The cautionary tale of Governor Eric Greitens is one such example that also signals another problem effecting the special ... "Outside of Russia and Belarus we train with virtually every country in Europe either bilaterally of through various ... In 2016 alone, U.S. Special Operations Command (SOCOM) conducted no less than 37 Joint Combined Exchange Training (JCET) ...
Railway enthusiast was killed by signal gantry as he leaned out of train. Posted Friday, 14 July, 2017 by bevans in UK ... Queensland Rail staffer sacked over issues linked to ongoing timetable problems. Posted Monday, 17 July, 2017 by bevans in ... 1b awarded for new trains and rail signals for Melbourne. Posted Wednesday, 19 July, 2017 by bevans in Victorian Rail News ... Melbourne train delays: Metro trains delayed due to fault. Posted Thursday, 20 July, 2017 by bevans in Victorian Rail News ...
Like trains, our bodies run on a timetable.. Joseph Mazur is professor emeritus of mathematics at Marlboro College. His ... In mammals that pacemaker indirectly detects neural signals of light and darkness from the eyes to play a central role in ... When the bees reached maturity they were trained to head in a given direction for at least five days.3 They learned the time of ... While studying bee routines at his lab at the University of Munich before World War II, Frisch trained bees to come regularly ...
2700 pulses in a bunch-train will be separated by 220 ns from each other with a 99.4 ms between the bunch-trains. One of the ... The 256 signal lines (x: 128 lines, y: 128 lines) are individually readout by signal-processing electronics. The element was ... Detailed timetable calendar file In order to enable an iCal export link, your account needs to have an API key created. This ... For high signals and slow readout speeds, this is a reasonable approximation. However, for low signals and higher readout ...
... as part of proposed rules to upgrade safety for trains carrying flammable fuels. ... Trains dont just put on a turn signal and zip around each other. ... This puts the U.S. on roughly the same timetable as Canada, which announced a phase out earlier this year. ... Trains with upgraded tank cars would be allowed to travel at 50 mph. Some experts had advocated for limiting oil trains to ...
Since the measured signal can be accurately calculated knowing the cross section from this signal the spatial emission profile ... As a consequence, the input quantities used to train and test the performance of the tools are not necessarily sampled by the ... Detailed timetable calendar file In order to enable an iCal export link, your account needs to have an API key created. This ... The optical system is equipped with a variable focusing in order to collect the signal mainly from the reactors center (R = 0 ...
Measuring the Socio-economic Benefits of Train Timetables: Application to Commuter Train Services in Stockholm2017In: 20th EURO ... of received signals. The PU signal is assumed to be temporally correlated. In this paper an Combine and Adapt (CTA) least Mean ... An example of such problems is the train timetabling problem. This paper focuses on solving a dual problem that arises from ... The article can be considered as an initiation to a novel method to calculate effects of changes in commuter train timetables. ...
However the train was held at a signal at Bere Ferrers, the soldiers not knowing the countryside thought that they were in ... Prior to the timetable change on the 1st January 2018 the 09.00 ran as the 08.44 from Penzance giving a connection with this ... On the night of the bombing Dad and another chap had seen Mum and another girl on to the Newquay train and then answered the ... Arriving at Plymouth on the 09.00 hours from Penzance at 10.54 I was just in time to see the 10.54 Gunnislake train departing ...
In addition, another option that helps to solve these problems is to use a large training dataset to train the ANN. In this ... For the relevant number of signal events we obtain a sub- stantial increase in signal sensitivity over existing analyses. We ... Detailed timetable calendar file In order to enable an iCal export link, your account needs to have an API key created. This ... Regularization methods vs large training Vega.pdf Regularization methods vs large training Vega.pdf Regularization methods vs ...
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"Halving the train path prices for freight traffic, as is currently under discussion in Germany, is a clear signal with an ... In the Benelux-Germany-Switzerland-Italy corridor, the same timetables are being used as in 2015. "90% of the potential savings ... But there are still restrictions in Germany and Belgium with regard to train length and in Italy with regard to train weight. ... "The parameters of 2000 t train weight with one engine, 740-metre train length and 4-metre profile are the basic prerequisites ...
Bladder training. *Delaying the event: The aim is to control urge. The patient learns how to delay urination whenever there is ... Toilet timetable: The person schedules bathroom at set times during the day, for example, every 2 hours. ... a spinal cord injury that impairs the nerve signals between the brain and the bladder ... Bladder training helps the patient gradually regain control over their bladder. Medications for urinary incontinence. If ...
Managing passenger vehicles circulating according to a fixed timetable, e.g. buses, trains, trams to a central station ; ... Method and device for converting a scanned image to an audio signal ... Managing passenger vehicles circulating according to a fixed timetable, e.g. buses, trains, trams ... Method and device for converting a scanned image to an audio signal ...
  • In-cab signalling is required to allow trains to be driven automatically between Kentish Town, Blackfriars, and London Bridge or Elephant & Castle, under driver supervision, in order to enable up to 24 trains to operate per hour from 2018. (railengineer.uk)
  • A Great Western Railway Class 158 train passes Pilning in 2018. (wikipedia.org)
  • Several Rockies starters performed well in 2017, and their potential and continued development could make the team's 2018 rotation the best in franchise history, Patrick Saunders of the Denver Post writes. (mlbtraderumors.com)
  • The heavy freight trains need one locomotive less on the flat track via Luino.This important productivity gain will only be possible on the route via Chiasso from 2020, when the Ceneri base tunnel starts operation. (transportweekly.com)
  • Talking about the timetable for AR revolution, Woodward says that if the applications are compelling enough, the early adaptors get hooked already by 2020, and a big breakthrough to the mainstream is to be expected around 2025. (wartsila.com)
  • Austria - Belgium: night train connections between Vienna/Innsbruck and Liège/Brussels will operate twice per week from mid January 2020, albeit with very late arrivals in/early departures from Brussels. (worldcarfree.net)
  • Austria - Germany: direct trains between Vienna and Berlin are boosted by the introduction of a new Graz - Vienna - Prague - Dresden - Berlin RailJet train pair and an overnight seated train pair (KISS double-decker) Vienna - Nuremberg - Saalfeld - Halle - Berlin - Rostock - Warnemünde, both from 4/5 May 2020. (worldcarfree.net)
  • Austria - Hungary: two pairs of RegioJet trains between Prague and Vienna are extended to/from Budapest from June 2020. (worldcarfree.net)
  • Czech Republic - Germany: the introduction of a Graz - Prague - Berlin train pair from 4/5 May 2020 means an earlier first arrival in Prague direct from Berlin and a later direct train from Prague to Berlin. (worldcarfree.net)
  • Prague - Berlin EuroCity trains are accelerated by around 17 minutes from 4/5 May 2020. (worldcarfree.net)
  • The complex Thameslink capacity upgrade programme includes the very visible civil engineering works in the London Bridge area and the introduction of Class 700 trains through the central London 'core' using European Train Control System (ETCS) Level 2. (railengineer.uk)
  • The core was resignalled with four-aspect signalling as part of the Thameslink Programme Key Output 1, described in issue 109 (November 2013). (railengineer.uk)
  • Network Rail's specification for the programme demanded that the performance of the interface had to support a peak flow of 86 trains per hour (tph) through London Bridge. (railengineer.uk)
  • The master's programme in Biomedical Sciences - Communication consists of compulsory components (e.g. courses, research projects, training period) and electives. (leidenuniv.nl)
  • Additional information on the programme, its regulations, schedules and timetable, etcetera can be consulted at LUMC's website and on Blackboard. (leidenuniv.nl)
  • The German and Norwegian programmes are so called EPIET-associated programmesas their participants are integrated in the modules and the supervision offered by EPIET, but salaries, facilitators, and training sites are provided by the national programme. (eurosurveillance.org)
  • We analyse activities and outputs of fellows of the European Programme for Intervention Epidemiology Training (EPIET) between 1995 and 2008 and describe the employment history of graduates after the training to demonstrate the contribution of this programme and of national EPIET-associated programmes to the public health workforce in the European Union and Norway. (eurosurveillance.org)
  • Since its founding in 1995, the European Programme for Intervention Epidemiology Training (EPIET) has become a core resource in training in intervention epidemiology in the EU. (eurosurveillance.org)
  • Also, a new training programme, the European public health microbiology training (EUPHEM), was set up in 2008 to increase the response capacity for microbiology. (eurosurveillance.org)
  • The Rangers could be entering their last Spring Training with Elvis Andrus (opt-out clause), Adrian Beltre (free agency), and Cole Hamels ($20MM club option for 2019) all in the fold, making this season a pivotal one for the franchise, Jeff Wilson of the Fort Worth Star-Telegram writes. (mlbtraderumors.com)
  • In particular, the nonlinear interdependence measure L is suited to be applied to spike trains from neurons. (uni-potsdam.de)
  • 1 . Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB, Kotaleski JH (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. (yale.edu)
  • The relay-based Westpac and Solid State interlockings (SSI), associated with the outmoded 1970s London Bridge Area Signalling Centre, are being progressively replaced with Siemens Trackguard Westlock computer-based interlockings controlled from Siemens Controlguide Westcad workstations at Three Bridges Rail Operating Centre (ROC). (railengineer.uk)
  • Passenger services also declined, to two trains per day in the 1970s and the current service level of two trains per week in 2006. (wikipedia.org)
  • So presumably the only way to get 5B02 to proceed from Turnham Green is to change the traction type in the timetable and restart the sim? (simsig.co.uk)
  • Siemens announced today that Rob Morris has been appointed Managing Director of its Rail Automation business in the UK, with effect from 1 December 2017. (siemens.co.uk)
  • Siemens Rail Automation is a global leader in the design, supply, installation and commissioning of track-side and train-borne signalling and train control solutions. (siemens.co.uk)
  • The U.S. government wants to phase out thousands of railroad tank cars that carry crude oil within two years once it adopts proposed rules to upgrade safety for trains carrying flammable liquids . (wsj.com)
  • This puts the U.S. on roughly the same timetable as Canada, which announced a phase out earlier this year. (wsj.com)
  • Attending an automobile forum over the weekend, Xin Guobin, China's vice minister of industry and information technology disclosed that the country had started research on a timetable to phase out production and sales of fossil fuel cars. (xinhuanet.com)
  • SAIP Phase 2 involves the soon-to-be-completed re-signalling of Stafford station, with scheme boundaries at Shugborough on the London line and Penkridge on the route to Wolverhampton. (railengineer.uk)
  • When prescribing WhMDs, skills training must include ascending/descending ramps at slopes encountered during boarding/ alighting to ensure safe and independent access to public transit buses. (worldwidescience.org)
  • DEER spectroscopy involves recording a dipolar modulation signal between two unpaired electrons and running regularized fitting to extract the distance distribution ( 13 , 14 ). (sciencemag.org)
  • After the nationalisation of the railway network in 1948, the use of the line as a through Liverpool to Manchester route declined but local commuter traffic levels remained significant (19 trains per day each way ran along the line in 1965, though a few ran non-stop between Liverpool & Wigan). (wikipedia.org)
  • Since the May 2014 changes though, most trains now run through to/from Rochdale again and since May 2015 continue onwards to Blackburn via Todmorden via the Caldervale Line. (wikipedia.org)
  • Work on the signalling equipment is taking place between Teddington and Shepperton closing the line. (nationalrail.co.uk)
  • Without it having an extension across Sturt Road to a purpose-built bus interchange and with the Clovelly Park car parking likely to be filled up by Tonsley Park precinct workers instead of train commuters, the Tonsley line really doesn't have much need for more than a single 3000 running a shuttle. (railpage.com.au)
  • All platforms at Stafford will become bi-directionally signalled and the line speed on the Up fast is to be increased. (railengineer.uk)
  • From this date there should be several daily train pairs running right through to/from Trutnov, for connections to/from the Czech main line network, instead of just the one. (worldcarfree.net)
  • Integreret i systemet er verdens første underjordiske jernbane, der åbnede i 1863 og nu udgør dele af Circle , Hammersmith & City og Metropolitan lines , samt den første undergrundsbane drevet med elektriske tog, siden 1890, som nu er en del af Northern line . (wikipedia.org)
  • On the Coast Line most of the semaphore signals were replaced by searchlights in the late 1940's. (blogspot.com)
  • Workers stand before mangled tanker cars after a train derailment and fire in Lac-Megantic, Quebec on July 6, 2013. (wsj.com)
  • Polish sample set Information concerning the audiometric status, MCC950 sodium cell signaling noise exposure and exposure to chemicals was gathered from 3860 Polish workers from different industries, including a coal mine, an electric power station, a dockyard, a glass bottle factory and a lacquer and paint factory. (buyresearchchemicalss.net)
  • Tracks are now funded for the entire corridor from Bakersfield north of Fresno to the wye where trains will eventually head off either north to Sacramento or northwest to San Francisco. (thetransportpolitic.com)
  • Dr. Marin Marinov is a Senior Research Associate with NewRail and responsible for the teaching portfolio of the centre, including a PhD opportunity scheme in Organisation, Management and Economics of Train Movement and Rail systems design. (ncl.ac.uk)
  • The new signalling includes 78 new signal heads, 176 axle counters and five WESTLOCK interlockings and is to be controlled from a desk at the Rugby Route Operating Centre (ROC). (railengineer.uk)
  • However all regular timetabled trains continued to terminate at Norden, with only occasional excursion trains running between the national rail network and the Swanage Railway. (wikipedia.org)
  • Testament to the integrated and collaborative approach taken by Govia Thameslink Railway (GTR), Siemens and Network Rail, another milestone was achieved last summer with a successful trial of a Class 700 train through the core using ETCS. (railengineer.uk)
  • It is managed by Great Western Railway , who provide the two train services per week from the station. (wikipedia.org)
  • The silk timetable would have been for use on the royal train as would the third item pictured - an undated but early map of the Midland Railway carrying the royal arms and also printed on silk and recently acquired by the Trust. (rfbmidlandtrust.org.uk)
  • The broad objective is to show tickets for travel from and to each station on the Midland Railway (including those for trains of other companies serving Midland stations), from and to each foreign station served by a Midland train and from and to each station on joint lines of which the Midland was a part owner. (rfbmidlandtrust.org.uk)
  • Idéen om en underjordisk jernbane til at forbinde City of London med nogle af jernbanestationerne lige udenfor centrum blev foreslået i 1830'erne, og Metropolitan Railway fik tilladelse til at bygge denne bane i 1854. (wikipedia.org)
  • Metropolitan District Railway (almindeligt kendt som District Railway ) fra South Kensington til Westminster åbnede i december 1868, som en del af en plan om en underjordisk "indre cirkel", der forbinder Londons fjerntogsterminaler. (wikipedia.org)
  • Den første dybtliggende tube -bane, City and South London Railway , to cirkulære tunneller med en diameter på 3,10 m, blev udgravet mellem King William Street (nær nutidens Monument Station ) og Stockwell under vejene for at undgå aftaler med ejerne af ejendommene på overfladen. (wikipedia.org)
  • In the United States, the term depot is sometimes used as an alternative name for station , along with the compound forms train depot , railway depot and railroad depot - it is used for both passenger and freight facilities. (wikipedia.org)
  • The world's first recorded railway station was The Mount on the Oystermouth Railway (later to be known as the Swansea and Mumbles ) in Swansea , Wales, which began passenger service in 1807, although the trains were horsedrawn rather than by locomotives. (wikipedia.org)
  • In July 2010, DCC and Purbeck District councils voted to allocate up to £3 million over three years, to part-fund re-signalling work needed at Worgret Junction to provide a more regular service. (wikipedia.org)
  • HSDA does the rest of the work by displaying a chart to the user that estimates how likely troops will experience heat illness during a training or operational scenario. (soldiersystems.net)
  • You can work as a Train or Tram Driver without formal qualifications, however, they may be useful. (joboutlook.gov.au)
  • Many Train and Tram Drivers work in Queensland. (joboutlook.gov.au)
  • However, they also need to be ready to provide the necessary resources, the administrative environment and long-term dedication to make field epidemiology training work. (eurosurveillance.org)
  • Train and Tram Drivers work in most parts of Australia. (joboutlook.gov.au)
  • From a theoretical standpoint, DEER is quite straightforward: Its dipolar modulation signal factorizes into spin pair contributions, dipolar interactions with remote spins are the only significant signal decay mechanism, and the broadening caused by that decay can be deconvolved because the decay function is available from the unmodulated background ( 12 ). (sciencemag.org)
  • Now that it looked like a searchlight signal we installed the mechanism. (blogspot.com)
  • Railroads, oil companies and railcar owners have been expecting new U.S. regulations meant to improve the safety of oil shipments in the wake of several fiery train accidents. (wsj.com)
  • Austria - Poland: the existing train pair Vienna - Krakow is extended at both ends, running through between Graz and Przemysl. (worldcarfree.net)
  • This layout was adopted both to avoid the need for through travellers to change platforms when changing trains and also for operational convenience - the lines to Fazakerley and Rainford are both single track (as noted previously), which facilitates the easy turnaround of trains here. (wikipedia.org)
  • When I try to use 'Edit Timetable' to select the next location in the TT I get an error message stating that there is no path from Highbury & Islington to Camden Road with the platforms selected, which I find strange as the trains have passed those locations before the reversing issue arises. (simsig.co.uk)
  • 90% of the potential savings in time is offset by waiting", explains Hans-Jörg Bertschi, chairman of the Board of Directors of Hupac Ltd, during the annual results media conference in Zurich on 1.6.2017. (transportweekly.com)
  • China may adopt a differentiated timetable, with big cities like Beijing and Shanghai achieving the goal as early as 2030, with less developed regions at a later time, he told CNR News. (xinhuanet.com)
  • Real-time interaction between yard and relevant network IT systems will also be studied to make it possible for real-time software-based planning and management of single wagonload and block-train services. (ncl.ac.uk)
  • See details of routes affected by planned engineering works, including when they take effect, maps of the affected area, alternative timetables, advice for alternative travel and real-time updates. (nationalrail.co.uk)
  • These consequences can cost the U.S. military valuable training time, money and operational readiness. (soldiersystems.net)
  • Results show that passenger behaviour, passenger volume, crowdedness in train and mixture of flow has significant effects on the alighting and boarding time though mixture of flow is not significant in the prediction model produced due to the passenger behaviour at the platform. (worldwidescience.org)
  • With weekly and rotational timetables, have everything you need to stay organised and get students to class prepared and on time. (bettshow.com)
  • Such fine grain structure may include assignment of personnel by name as well as the assignment of specific locomotives by number, and may include the determination of the precise time or distance over time for the movement of the trains across the rail network and all the details of train handling, power levels, curves, grades, track topography, wind and weather conditions. (google.com)
  • The ISI-distance, the SPIKE-distance, and SPIKE-synchronization are time-scale adaptive measures of spike train similarity that can be used for assessing similarity between two or more point processes. (uni-potsdam.de)
  • The timetable during this time will still be significantly reduced and fewer trains will run. (networkrailmediacentre.co.uk)
  • For tickets, train times and real-time information visit National Rail Enquiries , call 03457 48 49 50 , or contact your train company . (networkrail.co.uk)
  • Upsurge in harm qualified prospects to a widening of the original 4C6?kHz notch to lessen frequencies (ISO 1999 C International Corporation for Standardization, 1990), and the HTL in 3?kHz continues to improve over an extended MCC950 sodium cell signaling time period.34 This is helpful as the most the Swedish topics (79%) have been exposed to sound for 20C30 years or even more. (buyresearchchemicalss.net)
  • Naturally the TMS receives the timetable and network structure from the planning and collects data for the later analysis and controlling. (igi-global.com)
  • In this communication, we describe an attempt to process DEER data using artificial neural networks trained on large databases of simulated data. (sciencemag.org)
  • Source: ABS Labour Force Survey, Department of Jobs and Small Business trend data to May 2017 and Department of Jobs and Small Business projections to 2022. (joboutlook.gov.au)
  • The Republic( Best Navigation, Active TOC)( A to Z families) living addressed by Plato Doctors on 2017-10-21 and performed by A to Z pixels. (autoshop101.com)
  • The proposed requirements would apply to any train with 20 or more tank cars of oil, ethanol or a comparable fuel to be categorized as a 'high-hazard flammable train' and subject to the new rules. (wsj.com)
  • BEIJING, Sept. 11 (Xinhua) -- With the war on pollution in full swing, China has signalled its intention to join countries such as Britain and France with plans to ban the manufacturing and sales of cars running on traditional fuel. (xinhuanet.com)
  • A passenger on the Hiawatha was surprised to learn from me about the talking defect detectors that advise the crew of the condition of their train, no more hoping for a sharp eye at Sturtevant! (blogspot.com)
  • Cross-border trains are under particular threat for a variety of reasons, including lower demand and higher operating costs (than equivalent domestic routes), poor management and domestic and EU-level politics, compounded by the economic crisis. (worldcarfree.net)
  • 2017). Both of these sensors are linked to a recording machine, which shows a print-out or computer screen of the baby's heart rate and the mother's contractions shown together, often called EFM tracings . (evidencebasedbirth.com)
  • Most trains used continue to Rochdale prior to the December 2008 timetable change, but more recently ran to/from Stalybridge. (wikipedia.org)
  • The federal government's sweeping proposals come after a string of explosive derailments involving trains filled with oil from the Bakken Shale and will change how flammable liquids are transported in North America. (wsj.com)
  • Customers for Twickenham should change at Feltham for an alternative train service. (nationalrail.co.uk)
  • The nominations for the 2017 Product Design Awards will be published in the June 2017 issue of Get Connected, along with the voting form. (issuu.com)
  • The winners - those who have received the highest aggregate of points and votes in each category - will be published in the August 2017 issue. (issuu.com)
  • Nobody would ever mistake a 1750 hp diesel-hydraulic "Hymek" for a GP-9, and the on-train radios permitted crews of opposing trains or observers at the remaining open offices to alert the crews to troubles directly, none of this seven-bells-to-the-next-signalman to put signals at STOP (Danger, if you will) and advising the crew to walk the train. (blogspot.com)
  • The single track is broken up by a large buffer stop, which separates the electric Merseyrail trains from the diesel-run Northern services. (wikipedia.org)
  • This movement plan may be used to guide the manual dispatching of trains and controlling of track forces, or provided to the locomotives so that it can be implemented by the engineer or automatically by switchable actuation on the locomotive. (google.com)
  • The parameters of 2000 t train weight with one engine, 740-metre train length and 4-metre profile are the basic prerequisites for a cost-effective operation of the combined traffic," emphasises Bertschi. (transportweekly.com)
  • However, the existing lineside signals will be retained for the foreseeable future, facilitating the running of non-ETCS trains through the core while also providing a back-up for ETCS-fitted trains should the ETCS fail. (railengineer.uk)
  • The future of passenger trains via the train ferry Sassnitz - Trelleborg appears to be in doubt once again despite ever increasing demand. (worldcarfree.net)
  • 19 , 043028 [ PDF ] and arXiv [ PDF ] (2017) cSPIKE was developed by COSMOS ESR Eero Satuvuori ( Project 9 ). (uni-potsdam.de)
  • Invited to give a key note speech in CONEMB 2017 - III Congresso Nacional das Engenharias da Mobilidade, Joinville, Brazil, 19 - 22 September, 2017. (ncl.ac.uk)
  • Long Support arm on the ground Note:bearing surface for signal housing. (blogspot.com)
  • HSDA was developed by U.S. Army Research Institute of Environmental Medicine, or USARIEM, researchers based on over 30 years of studies on heat illness, hydration and core body temperature in simulated and realistic training environments. (soldiersystems.net)
  • The constant use and introduction of additional trains on to an outdated infrastructure is robbing years off the components. (railroad.net)
  • Heyman notes that Arizona has "signaled a willingness" to go to five years and more than $100MM, though John Gambadoro of 98.7 FM Arizona Sports tweets that, to the contrary, the D-backs aren't willing to go to that length to retain the slugger. (mlbtraderumors.com)
  • To meet the specification of 24tph through the Thameslink core section, it is necessary to deploy Automatic Train Operation (ATO). (railengineer.uk)
  • Although possible, I can't see a return of express trains as practical, given the network congestion that soon only gets even worse. (railpage.com.au)
  • Read on if you want to know why and what could be done to stop the deterioration of Europe's international passenger train network. (worldcarfree.net)