Toxicity Tests, Acute

Toxicity Tests

Toxicity Tests, Subchronic

Toxicity Tests, Chronic

Toxicity Tests, Subacute

Lethal Dose 50

Morinda

Animal Testing Alternatives

Water Pollutants, Chemical

Daphnia

Skin Irritancy Tests

Amphipoda

Toxicology

Artemia

Plant Extracts

Dose-Response Relationship, Drug

Toxicity

Protein toxicity

Animal testing

Timeline of the Deepwater Horizon oil spill (June 2010)

Timeline of the Deepwater Horizon oil spill (August 2010)

Timeline of the Deepwater Horizon oil spill

Joseph F. Holson

Bromobenzene

Toxicology testing

Michael Balls

Blood lead level

Classification of Pharmaco-Therapeutic Referrals

Fish acute toxicity syndrome

A1 broth

Bacteriological water analysis

Mysida

Draize test

Brachydesmus superus

Monsanto legal cases

Florence Margaret Durham

Wang Aiping (physician)

Viability assay

Industrial Bio-Test Laboratories

2,4-DB

Syntex

Pulmonary toxicity

Up-and-down procedure

Ecover

Cnidaria

Brine shrimp

Tricholoma terreum

Bohemic acid

Scuba set

Cortinarius gentilis

Neodymium

Congestion pricing

Indinavir

Selpercatinib

Tylosin

Esthesioneuroblastoma

Pemoline

Saksenaea vasiformis

Evidence-based Toxicology Collaboration

Restriction of Hazardous Substances Directive

Paleolithic

Bumblebee

Aflatoxin B1

The Age of Pioneers

Pembrolizumab

Baltimore Lead Paint Study

History of scuba diving

New car smell

Milk-alkali syndrome

Levothyroxine

P-Anisidine

Effects range low and effects range median

14-Cinnamoyloxycodeinone

Herbal medicine

RNA-targeting small molecule drugs

Oxycodone

Systemic Toxicity Testing2

• The U.S. strategy and roadmap is guiding replacement of animal use for required acute systemic toxicity testing. (nih.gov)
• Acute systemic toxicity testing provides the basis for hazard labeling and risk management of chemicals. (nih.gov)

Acute systemic toxicity5

• Acute systemic toxicity tests are used to assess the toxicity of chemicals, medical products, and other substances resulting from different types of exposure. (nih.gov)
• A number of international efforts have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity tests. (nih.gov)
• A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state-of-the-science of non-animal alternatives for this testing and explored ways to facilitate implementation of alternatives. (nih.gov)
• This table provides an outline of the some of the known mechanisms involved in acute systemic toxicity along with prototypical initiators. (nih.gov)
• Acute systemic toxicity data are often used to set a variety of reference values. (nih.gov)

Mold toxicity15

• Mold toxicity is a serious health issue that can lead to a range of symptoms and health problems. (editorialelduende.com)
• If you suspect that you may be suffering from mold toxicity, it is important to get tested as soon as possible. (editorialelduende.com)
• In this article, we will explore how to test for mold toxicity and what you can do if you are diagnosed with this condition. (editorialelduende.com)
• What is Mold Toxicity? (editorialelduende.com)
• Mold toxicity refers to the negative health effects that can result from exposure to mold. (editorialelduende.com)
• If you suspect that you may be suffering from mold toxicity, there are several different types of tests that can be used to diagnose the condition. (editorialelduende.com)
• How can I tell if I have mold toxicity? (editorialelduende.com)
• Symptoms of mold toxicity can include respiratory issues, skin irritation, neurological symptoms, and digestive problems. (editorialelduende.com)
• What are the long-term effects of mold toxicity? (editorialelduende.com)
• What can I do if I am diagnosed with mold toxicity? (editorialelduende.com)
• If you are diagnosed with mold toxicity, there are several steps you can take to improve your health. (editorialelduende.com)
• So don't wait - get tested for mold toxicity today! (editorialelduende.com)
• Mycotoxins suppress the immune system and inactivate white blood cells causing many adverse symptoms, serious health problems, mold toxicity and mycotoxin illness. (keine-ruhe.org)
• Many factors can play a role in mold toxicity from water damage in your home, school or workplace, to indoor humidity levels, genetic susceptibility, and your unique immune function. (keine-ruhe.org)
• Because many signs and symptoms of mold toxicity are invisible to everyone else, it often goes unsuspected until symptoms become disabling. (keine-ruhe.org)

Cell toxicity1

• Geochemical characterization and renal cell toxicity of water-soluble extracts from U.S. Gulf Coast lignite. (ouhsc.edu)

Chemicals5

• Though in vivo tests give an insight into systemic effects of chemicals, the physiological differences between animals and man can undermine extrapolation of animal data to the human system. (seurat-1.eu)
• Some plants contain chemicals that can cause symptoms similar to digitalis toxicity if they are eaten. (medlineplus.gov)
• A new test directly measures cell survival more quickly and cheaply than other ways of testing toxicity of chemicals and other exposures. (nih.gov)
• NIEHS grantees from the Massachusetts Institute of Technology (MIT) developed a new toxicity test that can directly and accurately measure the impact of chemicals on cell survival in a matter of days. (nih.gov)
• Proposed prioritization strategy for testing of chemicals for acute toxicity. (nih.gov)

Developmental toxicity1

• Human embryonic stem cell proliferation and differentiation as parameters to evaluate developmental toxicity. (ouhsc.edu)

20192

• During January-May 2020, 34% fewer U.S. children had BLL testing compared with those during January-May 2019, with an estimated 9,603 children with elevated BLLs missed. (cdc.gov)
• Compared with testing in 2019, testing during January-May 2020 decreased by 34%, with 480,172 fewer children tested. (cdc.gov)

Assay9

• Because theophylline is a minor metabolite of caffeine, a positive theophylline assay may be helpful in confirming suspected caffeine toxicity. (medscape.com)
• Instead, the new test, called the receptor binding assay for paralytic shellfish poisoning, uses the brain tissue of one rat to test about 200 shellfish samples. (foodsafetynews.com)
• For decades, the gold standard for measuring cell survival has been a test called the colony formation assay. (nih.gov)
• Few people use the colony formation assay anymore because it's difficult, way too slow, and requires huge amounts of cell growth media, so you need a lot of the compound being tested," said Bevin Engelward, Sc.D. , in the press release. (nih.gov)
• In their study, Engelward and her team set out to develop a test as accurate as the traditional assay and as quick as newer methods. (nih.gov)
• When the researchers compared results of the MicroColonyChip with both the traditional colony formation assay and newer, indirect tests, they found their invention performed as well, and in some cases better, than current approaches. (nih.gov)
• For example, when measuring cell survival after exposure to radiation, the MicroColonyChip was several times more sensitive than a popular cytotoxicity test called the XTT assay. (nih.gov)
• During Phase II of testing, the assay is optimized, validated, and miniaturized into a 1536-well plate format, followed by the robotic validation. (nih.gov)
• This format was applied in a 48 h Daphnia magna immobilisation assay to test the toxicity of a range of PAHs at their aqueous solubility. (uantwerpen.be)

Aquatic7

• To know the influence of mercury's toxic against aquatic organisms by using toxicity test. (e3s-conferences.org)
• An aquatic organism, which is usually used as toxicity test, is nilem fish ( Osteochilus hasselti ). (e3s-conferences.org)
• The acute fish toxicity test is used to assess the potential risk of substances to aquatic organisms. (toxstrategies.com)
• While the substance did meet the ecological categorization criteria for inherent toxicity to aquatic organisms, it did not meet the criteria for persistence or bioaccumulation. (gc.ca)
• The risk assessment of hydrophobic organic compounds (HOCs) in aquatic toxicity or bioconcentration tests is a challenge due to their low aqueous solubilities, sorption and losses leading to poorly defined exposure and reduced test sensitivity. (uantwerpen.be)
• This study characterised the performance of a passive dosing format for aquatic tests with small organism such as invertebrates and algae, consisting of PDMS silicone cast into the base of the glass test vessel. (uantwerpen.be)
• Therefore, passive dosing is a practical and economical means of improving the exposure of HOCs in aquatic toxicity or bioconcentration tests. (uantwerpen.be)

Theophylline5

• Patients with severe caffeine toxicity have had serum theophylline concentrations in the therapeutic range (10-20 mg/L). (medscape.com)
• Theophylline capsules can form bezoars, resulting in ongoing absorption and toxicity despite gastrointestinal decontamination. (medscape.com)
• Fisher J, Graudins A. Intermittent haemodialysis and sustained low-efficiency dialysis (SLED) for acute theophylline toxicity. (medscape.com)
• Seneff M, Scott J, Friedman B, Smith M. Acute theophylline toxicity and the use of esmolol to reverse cardiovascular instability. (medscape.com)
• Kearney TE, Manoguerra AS, Curtis GP, Ziegler MG. Theophylline toxicity and the beta-adrenergic system. (medscape.com)

Symptoms4

• The following laboratory studies are indicated in patients with moderate-to-severe symptoms of caffeine toxicity (ie, hemodynamic instability, dysrhythmias, seizures, altered mental status). (medscape.com)
• Call your provider if you are taking a digitalis medicine and you have symptoms of toxicity. (medlineplus.gov)
• These tests can help to determine whether you are allergic to mold and whether your symptoms are related to mold exposure. (editorialelduende.com)
• If you are experiencing any of these symptoms and suspect that you may have been exposed to mold, it is important to get tested. (editorialelduende.com)

Hematological1

• There were no histopathological changes or evidence of dose-responses in hematological and clinical chemistry measurements, including liver function tests. (nih.gov)

Substances1

• These tests are used to determine if substances need protective packaging, warning labels, and environmental release guides, or if protective equipment may be required for handling. (nih.gov)

Evaluation3

• Designed to provide essential information to all those involved with the evaluation of the toxicity of fire effluents not only in the development of meaningful test procedures but also in their use for mitigating hazards. (iso.org)
• Genetic Toxicity Evaluation of Dipropylene Glycol in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
• Home » Chemical Effects in Biological Systems (CEBS) » Genetic Toxicity Evaluation of Dipropylene Glycol in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)

20201

• Despite geographic variability, all health departments reported fewer children tested for BLL after the national COVID-19 emergency declaration (March-May 2020). (cdc.gov)

Lethal3

• Participants can use more concentrated stock solutions to test concentrations that determine the range for lethal, sub-lethal, or no effect. (nih.gov)
• Lethal toxicity concentration data were descriptive and data from sublethal toxicity test were One Way. (e3s-conferences.org)
• Lethal concentration 50% (LC50) values and experimental details were extracted and curated from 762 acute fish toxicity studies submitted to EPA for pesticide registrations. (toxstrategies.com)

Sprague-Dawley1

• A subchronic oral toxicity test of noni fruit was also performed in Sprague-Dawley (SD) rats to provide benchmark data for understanding the safety of noni juice, without the potential confounding variables associated with many commercial noni juice products. (nih.gov)

Serum1

• A serum pregnancy test is indicated in all women of childbearing age. (medscape.com)

Substance2

• An array of tests used to determine the toxicity of a substance to living systems. (ouhsc.edu)
• At present, there is a lack of suitable cell models that can express the major characteristics of liver function for predicting substance toxicity in humans . (bvsalud.org)

Potassium1

• A low level of potassium in the body can increase the risk of digitalis toxicity. (medlineplus.gov)

Exposure4

• A Comparison of Rodent and Nonrodent Laryngeal and Tracheal Bifurcation Sensitivities in Inhalation Toxicity Studies and Their Relevance for Human Exposure. (ouhsc.edu)
• Blood tests can be used to measure the levels of antibodies in the blood that are produced in response to mold exposure. (editorialelduende.com)
• This new method solves a major problem in toxicity testing today," said Daniel Shaughnessy, Ph.D. , program officer in the NIEHS Exposure, Response, and Technology Branch. (nih.gov)
• CDC and other health care organizations recommend routine blood lead level (BLL) testing among children as part of well-child examinations to facilitate prompt identification of elevated BLL, eliminate source exposure, and provide medical and other services ( 1 ). (cdc.gov)

Adverse1

• They also noted the importance of understanding the mechanisms of acute toxicity, which could be facilitated by the development of adverse outcome pathways. (nih.gov)

Findings2

• An increased anion gap (resulting from lactic acidosis) and hyperglycemia are also common findings in severe toxicity. (medscape.com)
• Describe pulmonary function test findings associated with asbestosis. (cdc.gov)

Organism1

• These can include panels of human cells or cell lines, rodent panels, including cell lines generated from rodent diversity panels, lower organism strains with well-characterized genetic backgrounds, or in silico approaches to enhance the ability to characterize the effects of genetic variation in toxicity testing. (nih.gov)

Cytotoxicity test2

• NICEATM coordinated a study of how in vitro cytotoxicity test methods could reduce animal use for acute toxicity testing. (nih.gov)
• ICCVAM evaluated the use of cytotoxicity test methods for acute toxicity testing. (nih.gov)

Vitro4

• To more fully evaluate the hepatotoxic potential of noni fruit juice, in vitro hepatotoxicity tests were conducted in human liver cells, HepG2 cell line. (nih.gov)
• An Adaption of Human-Induced Hepatocytes to In Vitro Genetic Toxicity Tests. (bvsalud.org)
• Metabolic activation is essential in standard in vitro genotoxicity test systems. (bvsalud.org)
• Resources identified as necessary for meaningful progress in implementing alternatives included compiling and making available high-quality reference data, training on use and interpretation of in vitro and in silico approaches, and global harmonization of testing requirements. (nih.gov)

Concentrations1

• Measure total creatine kinase (CK) concentrations to check for rhabdomyolysis, which is occasionally associated with severe caffeine toxicity. (medscape.com)

Populations1

• This Funding Opportunity Announcement (FOA) supports Phase I (R43), Direct to Phase II (R44), and Fast Track (R44) Small Business Innovative Research (SBIR) grant applications from small businesses concerns (SBCs) to develop resources and approaches, including panels of cells or model organisms, that can better reflect the variability in human populations in chemical toxicity testing. (nih.gov)

Rodent2

• Stark and his colleagues tested compounds against human and rodent cells. (phys.org)
• Current toxicology testing is often limited to studies conducted in a small number of laboratory rodent strains, which can fail to identify clinically relevant toxicity if the conventional rodent strain is particularly resistant to the toxic effects of the test compound. (nih.gov)

Oral3

• ICCVAM invited scientists to develop computer models to predict acute oral systemic toxicity. (nih.gov)
• The UDP is an alternative to the oral LD50 test that reduces animal use. (nih.gov)
• Oral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs. (ouhsc.edu)

Evaluate1

• The ECG should also be used to evaluate for the signs of other cardioactive drug toxicity, especially in cases of suicidal overdose. (medscape.com)

Invertebrates1

• Cigarette butts may have low toxicity to soil-dwelling invertebrates: Evidence from a land snail. (ouhsc.edu)

Clinical2

• These include tests on clinical drugs, foods, and environmental pollutants. (ouhsc.edu)
• Results showed treatment with Resveratrol and Longevinex did not result in any mortality of rats neither did they exhibit any clinical signs of toxicity. (nih.gov)

Studies1

• Thyroid studies should be considered because thyrotoxicosis can mimic caffeine toxicity. (medscape.com)

Irregular heart rhythm1

• How well a person does depends on the severity of the toxicity and if it has caused an irregular heart rhythm. (medlineplus.gov)

Species4

• The toxins come from algae and can be found in mussels, oysters, lobsters, crabs and even salmon, as well as other seafood species off the northern coasts of the U.S. So far, California is the only state that has agreed to switch over to the new test since it was approved by the Interstate Shellfish Sanitation Conference, Clippinger said, but others are likely on the way. (foodsafetynews.com)
• In the United States (U.S.), the test is typically conducted in three different fish species: a cold and a warm freshwater species and a marine/estuarine species. (toxstrategies.com)
• We conducted a retrospective analysis of data submitted to the U.S. Environmental Protection Agency (EPA) to support pesticide registrations to determine whether reducing the number of species tested would impact the ability of pesticide risk assessments to identify and characterize potential risks to fish. (toxstrategies.com)
• Data were analyzed to determine any trends among species in terms of relative differences in acute toxicity LC50 values. (toxstrategies.com)

Toxic effects1

• This guidance document addresses the approach to be taken for providing information on potential toxic effects, indicate target organs of toxicity and the possibility of accumulation, and to provide an estimate of a no-observed-effect level (NOAEL) of feed ingredients. (iccffeed.org)

Hazard1

• Animals are traditionally used for hazard identification, safety testing or disease modelling in pharmaceutical, (agro)chemical, food and environmental industry laboratories. (seurat-1.eu)

Routine1

• Routine testing can detect elevated BLLs. (cdc.gov)

Extracts1

• Skin tests involve injecting small amounts of mold extracts into the skin to see if an allergic reaction occurs. (editorialelduende.com)

Prevention1

• CDC funds 53 state and local childhood lead poisoning prevention programs to conduct ongoing surveillance of BLL testing among children. (cdc.gov)

Scientists2

• When scientists test a nanoparticle for its toxicity, often they are not compared with other nanoparticles, or with known toxic or nontoxic compounds. (phys.org)
• Cell survival tests can tell scientists a lot about the health of cells, and, in turn, their environment. (nih.gov)

Involves1

• The new test has been designed to replace the current industry-standard mouse bioassay toxicity test, which involves blending up samples of shellfish and injecting the mixture into the abdomens of live mice. (foodsafetynews.com)

Safety2

• The people in California are very excited and want to start using the new test right away," Clippinger told Food Safety News . (foodsafetynews.com)
• Regulatory statutes governing systemic toxicity data at the U.S. Consumer Product Safety Commission. (nih.gov)

Health1

• Providers and public health agencies need to take action to ensure that children who missed their scheduled blood lead screening test, or who required follow-up on an earlier high BLL, be tested as soon as possible and receive appropriate care. (cdc.gov)

Toxins2

• That means U.S. state fishery labs testing for shellfish toxins now have a more accurate and less expensive test that could save tens of thousands of mice a year, according to Amy Clippinger, science advisor for the PETA International Science Consortium. (foodsafetynews.com)
• Eight coastal state fisheries test for these paralytic shellfish toxins, which can cause a number of ailments, including facial paralysis, hypotension, vomiting and cardiovascular shock. (foodsafetynews.com)

Search1

• Results of search for 'su:{Toxicity tests. (who.int)

Potentially1

• Therefore, three separate acute fish toxicity tests are conducted for a single chemical, with each test potentially requiring 200 or more fish per chemical. (toxstrategies.com)

Data2

• Once fisheries amass enough screening data on clams and scallops, the test will be approved to replace the mouse test on those commodities as well. (foodsafetynews.com)
• Regulatory statutes governing systemic toxicity data. (nih.gov)

Approaches1

• Workshop breakout groups explored different approaches to reducing or replacing animal use for acute toxicity testing, with each group crafting a roadmap and strategy to accomplish near-term progress. (nih.gov)

Urine2

• Standard urine drug tests usually cannot detect ecstasy or methamphetamines. (medscape.com)
• Urine tests can be used to measure the levels of mycotoxins in the body. (editorialelduende.com)

Pulmonary4

• Pulmonary function tests. (cdc.gov)
• Screening pulmonary function tests are useful for finding restrictive deficits most commonly associated with asbestosis (see table). (cdc.gov)
• Some sources report abnormal pulmonary function tests in 50% to 60% of patients with asbestosis [Ross 2003]. (cdc.gov)
• The pulmonologist may recommend more extensive pulmonary function tests. (cdc.gov)

Compounds1

• Naphthalene and phenanthrene showed full toxicity at aqueous solubility, and passive dosing was also used for the concentrationresponse testing of these compounds. (uantwerpen.be)

Drug2

• A lower tolerance to the drug can also cause digitalis toxicity. (medlineplus.gov)
• The researchers say the test could be used for a wide variety of applications, such as drug development, environmental regulation, and personalized medicine. (nih.gov)

Mice1

• A newly approved shellfish toxicity test is quickly becoming music to the ears of fishery laboratory personnel, as well as the tens of thousands of mice whose lives the new test aims to save each year. (foodsafetynews.com)

Risk1

• They may develop digitalis toxicity if they have other risk factors. (medlineplus.gov)

Determine1

• These tests can help to determine whether you have been exposed to mold and whether your body is producing an immune response to the mold. (editorialelduende.com)