Toxicity Tests, Acute
Toxicity Tests
Toxicity Tests, Subchronic
Toxicity Tests, Chronic
Toxicity Tests, Subacute
Lethal Dose 50
Morinda
Animal Testing Alternatives
Water Pollutants, Chemical
Daphnia
Skin Irritancy Tests
Amphipoda
An order of mostly marine CRUSTACEA containing more than 5500 species in over 100 families. Like ISOPODA, the other large order in the superorder Peracarida, members are shrimp-like in appearance, have sessile compound eyes, and no carapace. But unlike Isopoda, they possess thoracic gills and their bodies are laterally compressed.
Toxicology
Artemia
Plant Extracts
Dose-Response Relationship, Drug
Euphoria
N-Methyl-3,4-methylenedioxyamphetamine
Hallucinogens
Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations, and other alterations of mood and thinking. Despite the name, the feature that distinguishes these agents from other classes of drugs is their capacity to induce states of altered perception, thought, and feeling that are not experienced otherwise.
Serotonin Agents
Poecilia
Amphetamines
3,4-Methylenedioxyamphetamine
Robotics
National Institute of Environmental Health Sciences (U.S.)
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research to reduce the burden of human illness and dysfunction from environmental causes by, defining how environmental exposures, genetic susceptibility, and age interact to affect an individual's health. It was established in 1969.
United States Environmental Protection Agency
Food Additives
Substances which are of little or no nutritive value, but are used in the processing or storage of foods or animal feed, especially in the developed countries; includes ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS (both plain and LOCAL); VEHICLES; EXCIPIENTS and other similarly used substances. Many of the same substances are PHARMACEUTIC AIDS when added to pharmaceuticals rather than to foods.
Environmental Health
Hazardous Substances
Inorganic Chemicals
Sodium Hypochlorite
Root Canal Irrigants
Chemicals used mainly to disinfect root canals after pulpectomy and before obturation. The major ones are camphorated monochlorophenol, EDTA, formocresol, hydrogen peroxide, metacresylacetate, and sodium hypochlorite. Root canal irrigants include also rinsing solutions of distilled water, sodium chloride, etc.
Reagent Kits, Diagnostic
Mutagenicity Tests
Mutagens
Micronucleus Tests
Eye Injuries
Ecotoxicology
Corneal Opacity
Practice Guidelines as Topic
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
Guidelines as Topic
A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.
Oligonucleotides
Guideline Adherence
Oligonucleotide Array Sequence Analysis
Oligonucleotides, Antisense
National Academy of Sciences (U.S.)
A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.
Education, Dental, Graduate
Carcinogenicity Tests
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
Neuropsychology
Preclinical safety evaluation of human gene therapy products. (1/1374)
Human gene therapy products include naked DNA and viral as well as non-viral vectors containing nucleic acids. There is limited experience on the preclinical toxicity studies necessary for the safety evaluation of these products, which have been outlined in several recently released guidelines. Requirements for the preclinical safety evaluation of human gene therapy products are both specific and non-specific. All key preclinical studies should be performed in compliance with Good Laboratory Practices. Non-specific requirements are in fact common to all pharmaceutical products. Critical specific issues to be addressed are: the safety evaluation of the vector and the toxicity of the expressed protein(s), which are the two components of gene therapy products, the quality of the test article, the selection of animal species, and the verification that the administration method successfully transports the gene of interest, with the vector, to the target site(s). The treatment schedule should mimic the intended human therapeutic design. The host's immune response against the gene therapy product has to be evaluated to detect possible adverse effects and immune neutralization by antibodies. The biodistribution of the gene of interest is also essential and can be evaluated by molecular biology techniques, such as PCR. Specific confinement is required for the safe manipulation of viral vectors. (+info)The contribution of acute toxicity in animals to occupational exposure limits of chemical substances. (2/1374)
The correlations of lethal doses of various industrial chemicals for rats and mice with occupational exposure limit values were investigated. 50% lethal dose (LD50) values obtained by oral (p.o.) and intraperitoneal (i.p.) injection and 50% lethal concentration (LC50) values obtained by inhalation exposure were collected from Registry of Toxic Effects of Chemical Substances (RTECS). Threshold Limit Value (Time-Weighted Average) (TLVs-TWA) and Threshold Limit Value (Short Term Exposure Limit) (TLVs-STEL) recommended by American Conference of Governmental Industrial Hygienists (ACGIH) were used as exposure limits. TLVs-TWA or TLVs-STEL and LD50 or LC50 values obtained for the rats were plotted on logarithmic scales on the ordinate and abscissa, respectively. High correlations were obtained between these parameters. The order of correlations was: TLVs-STEL vs. LC50s > TLVs-TWA vs. LC50s > TLVs-TWA vs. LD50s i.p. > TLVs vs. LD50s p.o. The same calculations for the relationship between TLVs and lethal doses in mice were also performed. The order of the three types of correlations was same as that of the rats; however, correlation coefficients for TLVs-STEL vs. LC50s and for TLVs-TWA vs. LC50s obtained in mice were smaller than those in rats. TLVs-TWA are, therefore, well correlated with LC50 values rather than LD50 values, particularly with those in rats. High correlations between TLVs-STEL vs. LC50s were also obtained, as had been expected before calculation. The equation: TLV-TWA = 10b x (LC50)a can be obtained from these plottings, where the values a and b are taken from each linear regression line. TLV-TWA for each chemical can be calculated by using LC50 and the equation. The upper and lower 95% confidence limits for calculated TLV-TWA were TLV-TWA (calculated from LC50) x 22.9 and TLV-TWA (calculated)/22.9, respectively, where LC50 for rats expressed in ppm x hr was used. (+info)The marginalization of hormesis. (3/1374)
Despite the substantial development and publication of highly reproducible toxicological data, the concept of hormetic dose-response relationships was never integrated into the mainstream of toxicological thought. Review of the historical foundations of the interpretation of the bioassay and assessment of competitive theories of dose-response relationships lead to the conclusion that multiple factors contributed to the marginalization of hormesis during the middle and subsequent decades of the 20th Century. These factors include the following: (a) the close association of hormesis with homeopathy, which led to the hostility of modern medicine toward homeopathy, thereby creating a guilt-by-association framework, and the carryover influence of that hostility toward hormesis in the judgements of medically based pharmacologists/toxicologists; (b) the emphasis of high-dose effects linked with a lack of appreciation of the significance of the implications of low-dose stimulatory effects; (c) the lack of an evolution-based mechanism(s) to account for hormetic effects; and (d) lack of appropriate scientific advocates to counter aggressive and intellectually powerful critics of the hormetic perspective. (+info)Chemical hormesis: its historical foundations as a biological hypothesis. (4/1374)
Despite the long history of hormesis-related experimental research, no systematic effort to describe its early history has been undertaken. The present paper attempts to reconstruct and assess the early history of such research and to evaluate how advances in related scientific fields affected the course of hormesis-related research. The purpose of this paper is not only to satisfy this gap in current knowledge but also to provide a foundation for the assessment of how the concept of hormetic dose-response relationships may have affected the nature of the bioassay, especially with respect to hazard assessment practices within a modern risk assessment framework. (+info)Serum vitellogenin levels and reproductive impairment of male Japanese Medaka (Oryzias latipes) exposed to 4-tert-octylphenol. (5/1374)
The induction of synthesis of the "female" yolk precursor protein vitellogenin (VTG) in male fish by estrogenic chemicals in the environment has been demonstrated in many recent reports. However, little is known about the organismal and biological significance of this phenomenon. To examine the relationship between VTG production in male fish and reproductive impairment, adult male medaka were exposed to 4-tert-octylphenol (OP), a known environmental estrogen, in concentrations ranging from 20 to 230 ppb for 21 days, under flow-through conditions. Following exposure, male fish were mated, in the absence of OP, with unexposed females. Breeding groups composed of exposed males and control females produced about 50% fewer eggs than control groups. VTG levels in serum of male fish increased with increasing OP exposure concentration and decreased after OP exposure was discontinued. Nevertheless, significant correlations (p<0.01) were observed between VTG levels in exposed male fish and 1) OP exposure concentrations, 2) percent of fertilized eggs, and 3) survival of embryos. OP-induced VTG synthesis and reproductive impairment appear to be closely linked phenomena. Histological examination indicated spermatogenesis in OP-exposed fish was inhibited, and some exposed fish had oocytes in their testes. Finally, OP caused a significant increase in the number of abnormally developing embryos, suggesting that OP may be genotoxic as well as estrogenic. (+info)Demonstration of the pathogenic effect of point mutated keratin 9 in vivo. (6/1374)
A wild type keratin 9 (K9) cDNA and a point mutated keratin 9 cDNA were injected subcutaneously into mouse skin. The hemagglutinin tag staining of the wild type K9 cDNA injected specimens mainly showed a homogeneous pattern, whereas the point mutated K9 cDNA injected specimens mainly showed a granular pattern in the suprabasal cells. Double staining of K9 and the endogenous keratin revealed the incorporation of de novo synthesized K9 into the keratin network. These results demonstrate that (1) a naked DNA transfection into mouse skin can detect the pathogenic changes of point mutated keratin in vivo and (2) the keratin 9 mutation disrupts the keratin network formation in the suprabasal cells in vivo. (+info)Changes in thyroid gland morphology after acute acrylamide exposure. (7/1374)
High exposure to the acrylamide monomer has been associated with neuropathy and neurotoxic effects. Chronic lower exposure causes endocrine disruption associated with thyroid, testicular, and mammary tumors. To investigate mechanisms of endocrine disruption, short-term, low-level oral dosing studies were conducted. Weanling female Fischer 344 rats were acclimatized for two weeks before dosing. Controls were given distilled water by gavage and rats in other groups were given acrylamide at doses of 2 mg/kg/day and 15 mg/kg/day for 2 or 7 days by gavage. Twenty-four h after the last dose, the rats were killed by decapitation. Trunk blood was collected for hormone analyses and tissues for histopathological examination. There were no toxicity-related deaths, no clinical signs of toxicity, and no significant difference in the mean body weight of animal groups. Histopathological examination of select tissues showed no lesions of pathologic significance. Plasma thyroxine (T4), thyroid stimulating hormone (TSH), prolactin (PRL), and pituitary TSH and PRL analyses did not reveal significant changes between control vs. treated rats. In the 7-day study, however, there was a slight dose-dependent increase in plasma T4 and a slight dose-dependent decrease in plasma TSH. Thyroid gland morphometry showed a significant (p < 0.05) decrease in the colloid area and a significant increase (p < 0.05) in the follicular cell height of treated rats as compared to controls. The follicular area shrinkage was similar in both studies. These results show a very early endocrine response to very low levels of toxic insult and opens other venues to further investigate the mechanisms of endocrine disruption by acrylamide. (+info)Effects of acute exposure to PCBs 126 and 153 on anterior pituitary and thyroid hormones and FSH isoforms in adult Sprague Dawley male rats. (8/1374)
3,3'4,4',5-Pentachlorobiphenyl (PCB 126) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) were administered to adult male rats in order to identify sensitive indicators of endocrine disruption. We tested the hypothesis that PCB exposure modifies follicle-stimulating hormone (FSH) pituitary isoforms, as well as the pituitary and serum concentrations of FSH, luteinizing hormone (LH), growth hormone, prolactin, and thyroid-stimulating hormone (TSH). Effects on serum levels of thyroxine (T4) and testosterone (T), and prostate androgen receptor content, were also tested. In one experiment, 5 groups of 8 rats each received two i.p. injections, one day apart, of either corn oil or 6.25, 25, 100 or 400 micrograms/kg/day of PCB 126. Decreases (p < 0.05) in the serum concentrations of T4 and LH started at doses of 25 and 100 micrograms/kg/day, respectively. Serum FSH concentrations were reduced (p = 0.07) in the highest dose group. In contrast, pituitary content of FSH and LH increased with PCB-126 doses (p = 0.004, p = 0.002, respectively). Despite changes in reproductive hormones, PCB-126 had no effect on the androgen receptor content of the prostate. The effect of PCB-126 was tested in the hemicastrated rat, and suggested adverse effects on testosterone secretion. To test the effects of PCB exposure on FSH pituitary isoforms, 4 groups of 10 male rats received two i.p. injections, one day apart, of either corn oil, PCB 153 (25 mg/kg/day), estradiol-17 beta (E2; 20 micrograms/kg/day), or PCB 126 (0.1 mg/kg/day). Serum T4 levels were higher (p < 0.01) in the E2 and PCB 153 groups, and slightly reduced in the PCB 126-treated groups, compared to controls. Simultaneous purification of pituitary FSH and TSH isoforms was performed by HPLC, using two chromatofocusing columns in series. In contrast to TSH isoforms, the distribution of FSH isoforms over the chromatography run differed slightly between treatment groups; the amounts of FSH isoform eluted during the pH gradient were lower (p < 0.05) in E2 and PCB 153-treated rats than in control or PCB 126-treated rats. The similarity between the effects of E2 and PCB 153 on T4 and FSH isoforms supports the contention that PCB 153 possesses estrogenic properties. Serum LH and T4 concentrations were the most sensitive and practical endocrine indicators of PCBs 126 and 153 exposure in male rats. (+info)
Japan: unsaturated polyester resins for fiber glass reinforced plastics production volume 2019 | Statista
reaction mass of... - Registration Dossier - ECHA
3-isocyanatomethyl-3,5,5-trimethylcyclohexyl... - Registration Dossier - ECHA
REACH Regulation / EU REACH Services | BioReliance
Systems Toxicological Assessment of two Modified Risk Tobacco Products on Cardiovascular and Respiratory Effects in ApoE-/-mice...
9 Effects of Jet-Propulsion Fuel 8 on Reproduction and Development | Toxicologic Assessment of Jet-Propulsion Fuel 8 | The...
Nanomaterials | Free Full-Text | Neural Cell Chip Based Electrochemical Detection of Nanotoxicity
Evaluation of Preclinical Toxicity andTherapeutic Efficacy of Kandhaga Rasayanam in Padarthamarai - Full Text View -...
Brevet US5228972 - Apparatus for measuring concentration of test substance in liquid - Google Brevets
chemical toxicity
especially using newly available toxicity test methods. Structure of Study Team for Nano-Associated Security Assessment RT-NASA...
Regulatory Toxicology and Pharmacology Archives - Bioscription
Search results
Data Collection and Reports
2014 February
Human Health Exposure Assessment for Rocky Mountain Arsenal. Volume 2-A. Toxicity Assessment. Version 4.1
03/12/2009: EPA Releases Comprehensive Database on Environmental Chemicals
BioDuro & The National Center for Safety Evaluation of Drugs Received Full AAALAC Acc... ( BEIJING April 18 /- BioDuro &...
A New Era in Environmental Chemical Testing: ToxCast Phase I Chemicals Announced on Environmental XPRT
PREDART | Innovation Platform
In vitro platform for retinal toxicity assessment and disease modelling | Innovation Platform
Novel pGL4 Reporter Vector Panel for Profiling Cellular Stress and Chemical Toxicity
No Safe Amount: The Handshake Theory of Chemical Toxicity
AMR Centre, Shionogi team up for superbug therapy - PharmaTimes
ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies |...
Hydraulic Injection Molding
Trina ALLMAX 255W Solar Module - Modern Outpost
BRE Group: Fire toxicity assessment
PNNL: Measurements at the Genome-Scale Made in Nanotoxicity Study
Browsing Department of Biology by Subject Estrogen -- Toxicity testing -- In vitro.
Redbook 2000: IV.C.3.a. Short-Term Toxicity Studies with Rodents | FDA
XIENCE 90: A Safety Evaluation of 3-month DAPT After XIENCE Implantation for HBR Patients. | Clinical Research Trial Listing (...
Keresés a következőre In vitro toxicity
Interceptor® Plus Fully Encapsulating EN 943 Type 1a… | Lakeland
Rifapentine-proliposomes for inhalation: In vitro and In vivo toxicity
Toxicity Identification (TI)/Reduction Evaluations (RE) ...
Methyl Isobutyl Ketone (MIBK)
Principles for the Toxicological Assessment of Pesticide Residues in Food: Environmental Health Criteria Series 104 by ILO |...
Search | Korea Science
Criteria for Reporting and Evaluating ecotoxicity Data (CRED): comparison and perception of the Klimisch and CRED methods for...
A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week,...
A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week,...
Toxicity assessment of chlorophenols using a mediated microbial toxicity assay
Alternative Approaches to Vertebrate Ecotoxicity Tests in the 21st Century: A Review of Developments Over the Last 2 Decades...
Estimation of systemic toxicity of acrylamide by integration of in vitro toxicity data with kinetic simulations.
6-methyl-1,3,5-triazine-2,4-diyldiamine - Registration Dossier - ECHA
Methyl Isobutyl Ketone Detection Tubes (2.5 to 130 ppm) | 153L | GasTec
Will Methyl Isobutyl Ketone (MIBK) Market carry its growth momentum post COVID-19? Read more to know - iCrowdNewswire
methyl isobutyl ketone Supplier - Meru Chem Pvt. Limited
Cell Culture Methods for In Vitro Toxicology | Springer for Research & Development
A transcriptome-based classifier to identify developmental toxicants by stem cell testing : design, validation and optimization...
Hepatotoxicity Assay & In Vitro Toxicology - INDIGO Biosciences
ASTM E724 : Standard Guide for Conducting Static Acute Toxicity Tests Starting with Embryos of Four Species of Saltwater...
Microbial contamination and chemical toxicity of the Rio Grande | BMC Microbiology | Full Text
Reaction products of... - Registration Dossier - ECHA
Prepare Flexible Budgets - Principles of Accounting, Volume 2: Managerial Accounting
Daqo New Energy Corp. Announces Second Quarter 2014 Results | Singapore News Gazette
Brazils 2009 Ethanol Production Volume Set to Break Records | Renewable Energy World
Production Volume Variances - Standard Costing and Variance Analysis | Coursera
N-(2-(4-amino-N-ethyl-m-toluidino)ethyl)methane... - Registration Dossier - ECHA
Aquatic toxicity testing of sparingly soluble, volatile, and unstable substances and interpretation and use of data. Task Force...
The use of in vivo imaging to study pregnancy in non-rodent animals - Institut National de Recherche en Agriculture,...
Diphenyl sulphone - Registration Dossier - ECHA
Liver Hypertrophy: A Review of Adaptive (Adverse and Non-adverse) Changes-Conclusions from the 3rd International ESTP Expert...
The blood supply of the male reproductive organs - Stock Image F002/2443 - Science Photo Library
The blood supply of the male reproductive organs - Stock Image F002/2809 - Science Photo Library
NICEATM Support of the Tox21 Program
Dermal Absorption and Toxicity Assessment, Second Edition: by Michael S. Roberts - Ideal Accessories Books
One-Step Synthesis of Methyl Isobutyl Ketone from Acetone and Hydrogen over Cu-on-MgO Catalysts
AZT + Rifabutin (AIDS Initiative) M950055
Establishing the Level of Safety Concern for Chemicals in Food without the Need for Toxicity Testing | ILSI Europe
Depleted uranium
Decreased performance on neurocognitive tests Acute cholinergic toxicity; Dose-dependent accumulation in cortex, midbrain, and ... Chemical toxicity[edit]. The chemical toxicity of depleted uranium is identical to that of natural uranium and about a million ... Epidemiological studies and toxicological tests on laboratory animals point to it as being immunotoxic,[96] teratogenic,[97][98 ... After testing various metals, ordnance researchers settled on depleted uranium. The US and NATO militaries used DU penetrator ...
Effects of cannabis
Toxicities[edit]. Related to cannabinoids[edit]. No fatal overdoses with cannabis use have been reported as of 2006.[24] A ... long-term users can produce positive tests for two to three months after ceasing cannabis use (see drug test).[23] ... "Chemicals known to the state to cause cancer or reproductive toxicity" (PDF). ca.gov. 2012-07-20. Archived from the original ( ... THC, the principal psychoactive constituent of the cannabis plant, has an extremely low toxicity and the amount that can enter ...
MDAI
No tests have been performed on cardiovascular toxicity.[1][12][13][14][15][16][17] ... August 2016). "Emerging toxicity of 5,6-methylenedioxy-2-aminoindane (MDAI): Pharmacokinetics, behaviour, thermoregulation and ... toxicity: a brief overview and update". Human Psychopharmacology. 28 (4): 345-55. doi:10.1002/hup.2298. PMID 23881883.. ...
Cruelty-free
Gallagher, Megan Erin (2003). Toxicity Testing Requirements, Methods and Proposed Alternatives (PDF). Environs. 26. p. 253.. ... These tests not only reduce animal testing, but are more precise and accurate at protecting humans from toxic substances.[10] ... Products tested on animals are not considered cruelty-free, since these tests are often painful and cause the suffering and ... Other methods replace the Draize eye test by using in vitro (test-tube) human tissue. Computer-based systems allow for ...
Heavy water
Main article: Doubly labeled water test. Heavy water is employed as part of a mixture with H218O for a common and safe test of ... Toxicity in humans[edit]. Because it would take a very large amount of heavy water to replace 25% to 50% of a human being's ... See doubly labeled water testing. Since one in about every 6,400 hydrogen atoms is deuterium, a 50 kg human containing 32 kg of ... The quantity of heavy water involved was far below levels that could induce heavy water toxicity, but several employees ...
Brine shrimp
... has had extensive use as a test organism and in some circumstances is an acceptable alternative to the toxicity testing of ... Toxicity testEdit. Artemia found favor as a model organism for use in toxicological assays, despite the recognition that it is ... L. Lewan; M. Anderrson & P. Morales-Gomez (1992). "The use of Artemia salina in toxicity testing". Alternatives to Laboratory ... makes them ideal animals running biological toxicity assays and it has become a model organism used to test the toxicity of ...
Hyalella azteca
... are used in various aquatic bioassays., (also called toxicity tests). [8] Because of their wide distribution, ... "Use of the amphipod crustacean Hyalella azteca in freshwater and estuarine sediment toxicity tests". EPA Science Inventory. ... "Use of the amphipod crustacean Hyalella azteca in freshwater and estuarine sediment toxicity tests". EPA Science Inventory. ... 2020). Testing the bioaccumulation potential of manufactured nanomaterials in the freshwater amphipod Hyalella azteca. ...
Timeline of the Deepwater Horizon oil spill (June 2010)
"Toxicity Testing of Dispersants , EPA Response to BP Spill in the Gulf of Mexico , US EPA". Epa.gov. Retrieved 2010-07-01. " ... "Unified Command for the BP Oil Spill , NOAA Conducts Tests to Determine Fate of Whale Found Dead in Gulf of Mexico". ... "EPA's results indicated that none of the eight dispersants tested, including the product in use in the Gulf, displayed ... BP announces plans to have the well testing vessel Toisa Pisces replace the Discoverer Enterprise for bringing oil to the ...
Timeline of the Deepwater Horizon oil spill (August 2010)
"Toxicity Testing of Dispersants , EPA Response to BP Spill in the Gulf of Mexico , US EPA". Epa.gov. Retrieved 2010-08-03. " ... "Comparative Toxicity of Louisiana Sweet Crude Oil (LSC) and Chemically Dispersed LSC to Two Gulf of Mexico Aquatic Test Species ... "EPA Releases Second Phase of Toxicity Testing Data for Eight Oil Dispersants , Restore the Gulf". App.restorethegulf.gov. ... BP exec Doug Suttles says he would eat seafood from the Gulf saying, "There's been a tremendous amount of testing done by NOAA ...
Timeline of the Deepwater Horizon oil spill
"Toxicity Testing of Dispersants , EPA Response to BP Spill in the Gulf of Mexico , US EPA". Epa.gov. Retrieved August 3, 2010 ... Conducting the test would have taken 9-12 hours and $128,000. By canceling the cement test BP paid only $10,000. Crew leaves on ... "EPA Releases Second Phase of Toxicity Testing Data for Eight Oil Dispersants , Restore the Gulf". App.restorethegulf.gov. ... Tests begin on testing well integrity. Salazar issues a new moratorium until November 30 on deepwater wells that use a blowout ...
Joseph F. Holson
"Nonclinical Juvenile Toxicity Testing". In Hood, R.D. (ed.). Developmental and Reproductive Toxicology: A Practical Approach, ... Early in Holson's career, while at NCTR, he led studies that assessed the developmental toxicity of FD&C Red No. 2, an amaranth ... Holson, J. F.; Stump, D. G.; Pearce, L. B.; Watson, R. E.; DeSesso, J. M. (2015-04-01). "Absence of developmental toxicity in a ... Stump, D. G.; Holson, J. F.; Harris, C.; Pearce, L. B.; Watson, R. E.; DeSesso, J. M. (2015-04-01). "Developmental toxicity in ...
Carbonyl sulfide
Toxicity[edit]. As of 1994, limited information existed on the acute toxicity of carbonyl sulfide in humans and in animals.[3] ... In tests with rats, 50% animals died when exposed to 6997140000000000000♠1400 ppm of COS for 90 minutes, or at ...
Cnidaria
Blaise, C.; Férard, J-F. (2005). Small-scale Freshwater Toxicity Investigations: Toxicity Test Methods. Springer. p. 398. ISBN ...
Titanium dioxide
"Nano World: Nanoparticle toxicity tests". Physorg.com. 5 April 2006. Retrieved 12 April 2010. "Titanium dioxide" (PDF). 93. ... Koleske, J. V. (1995). Paint and Coating Testing Manual. ASTM International. p. 232. ISBN 978-0-8031-2060-0. Koleske, J. V. ( ... In 2016 Scientific Committee on Consumer Safety (SCCS) tests concluded that the use of nano Titanium Dioxide (95%-100% rutile ... These studies were later refuted, when it was discovered that the testing methodology couldn't differentiate between penetrated ...
Bromobenzene
Animal tests indicate low toxicity. Little is known about chronic effects. For liver toxicity, the 3,4-epoxide are proposed ...
Hypervitaminosis A
Types of toxicityEdit. *Acute toxicity occurs over a period of hours or a few days, and is less of a problem than chronic ... blood test for vitamin A. Relevance of blood testsEdit. Retinol concentrations are nonsensitive indicatorsEdit. Assessing ... Sources of toxicityEdit. *Diet - liver is high in vitamin A. The liver of certain animals - including the polar bear, bearded ... Vitamin A toxicity has long been known to the Inuit and has been known by Europeans since at least 1597 when Gerrit de Veer ...
Cypermethrin
I. Acute toxicity to some freshwater fish and invertebrates in laboratory tests". Aquatic Toxicology. 2 (3): 175-185. doi: ...
United States Environmental Protection Agency
A few challenges this program faces are transforming toxicity testing, screening pesticides for endocrine disruptors, and ... In 1996, the EPA proposed updating the Federal Testing Procedures[81] to add a new higher-speed test (US06) and an air- ... The EPA conducts fuel economy tests on very few vehicles. "Just 18 of the EPA's 17,000 employees work in the automobile-testing ... "SAB Pushes To Advise EPA To Conduct Toxicity Tests In Fracking Study". InsideEPA. Inside Washington Publishers. (subscription ...
United States Environmental Protection Agency
"SAB Pushes To Advise EPA To Conduct Toxicity Tests In Fracking Study". InsideEPA. Inside Washington Publishers. (subscription ... In 1996, the EPA proposed updating the Federal Testing Procedures[46] to add a new higher-speed test (US06) and an air- ... The EPA conducts fuel economy tests on very few vehicles. "Just 18 of the EPA's 17,000 employees work in the automobile-testing ... Later road tests found better, but inconclusive, results.[112][113] Mercury emissions, 2005[edit]. In March 2005, nine states ( ...
Classification of Pharmaco-Therapeutic Referrals
Toxicity S 2. Interaction S 3. Allergy S 4. Addiction (dependence) S 5. Other side effects S 6. Contraindication S 7. ... Complementary test for treatment control N 7. Administrative activity N 8. On patient request (fears, doubts, wants). S 0. ...
A1 broth
"Southeast Asian experiences with the coliphage test". Toxicity Assessment. 3 (5): 551-564. doi:10.1002/tox.2540030510. Archived ... Variants of this test has been used for potable water across the globe, for example by the Cree community of Split Lake, ... "Portable Water-testing Kit: International Development Research Centre". Archived from the original on December 4, 2007. CS1 ... Gently heat until completely dissolved and distribute 9 ml into test tubes with an inverted Durham tube. Sterilize in an ...
Bacteriological water analysis
"Performance Verification Testing; Rapid Toxicity Monitoring and Detection Systems; Overview and Analysis". Washington, DC: US ... An ATP test is the process of rapidly measuring active microorganisms in water through detection adenosine triphosphate (ATP). ... Second generation ATP tests are specifically designed for water, wastewater and industrial applications where, for the most ... Approved CWA Microbiological Test Methods. EPA. October 2002. EPA 821-R-02-026. Hanaor, Dorian A. H.; Sorrell, Charles C. (2014 ...
Mysida
Nimmo, D. R.; Hamaker, T. L. (1982). "Mysids in toxicity testing - a review". Hydrobiologia. 93 (1-2): 171-178. doi:10.1007/ ... Americamysis bahia and Americamysis almyra are frequently used to test for pesticides and other toxic substances, with A. bahia ...
Monsanto legal cases
Marshall, E. (1983). "The murky world of toxicity testing". Science. 220 (4602): 1130-1132. Bibcode:1983Sci...220.1130M. doi: ... Bowman tested the new seeds, and found that, as he had expected, some were resistant to glyphosate. He intentionally replanted ... "Mass Roundup Settlement Could Test the Limits of Tort Law". Walden Consultants LLC. 2019-05-24. Retrieved 2019-12-18. "Bayer's ... Schneider, Keith "Faking it: The Case against Industrial Bio-Test Laboratories", Amicus Journal, Spring 1983. Novak, Roger A. ( ...
Florence Margaret Durham
Toxicity Tests for Novarseno-benzene (Neosalvarsan). London, Medical Research Council Special Report No. 128 Hurst, C. C. ( ...
Wang Aiping (physician)
Blood and Biochemical Test Manual; Dermal Toxicity Test Standard Operating Manual";"Genetic Toxicology Testing Standard ... For over 20 years, Wang has researched drug and toxicity testing and has experience in new drug development. Since 2001, he has ... Long-Term Toxicity Test Standard Operating Manual; Common Instruments Using Standard Operating Manual; Animal Husbandry ... He has developed test methods, several of which are included in Pharmacology Research Methodology (Peoples Health Press, 2nd ...
Viability assay
High-Throughput Screening Methods in Toxicity Testing. John Wiley & Sons, Inc. pp. 107-127. doi:10.1002/9781118538203.ch5. ISBN ... These techniques can be used to assess the success of cell culture techniques, cryopreservation techniques, the toxicity of ... Wusteman MC, Pegg DE, Robinson MP, Wang LH, Fitch P (February 2002). "Vitrification media: toxicity, permeability, and ... but its test cells are diluted in liquid and then kept in liquid through the examination process. The "tadpoling" method can be ...
2,4-DB
It is classified in toxicity class III. It shows some evidence of toxicity to dogs and cats, such as changes in body weight and ... Tests of carcinogenicity in this range yielded differing results. It is moderately toxic to fish. "Extension Toxicology Network ...
Syntex
Marshall, Eliot (1983-06-10). "The murky world of toxicity testing" (PDF). Science. 220 (4602): 1130-1132. Bibcode:1983Sci... ... CS1 maint: discouraged parameter (link) "The Scandal in Chemical Testing". The New York Times. 1983-05-16. Retrieved 2012-07-27 ... CS1 maint: discouraged parameter (link) Merrell, Paul (Winter 1981). "The Industrial Bio-Test Caper" (PDF). NCAP News. 2 (3): 2 ... naproxen largely led to the Food and Drug Administration's uncovering of extensive scientific misconduct by Industrial Bio-Test ...
Titanium dioxide
"Nano World: Nanoparticle toxicity tests". Physorg.com. 5 April 2006. Retrieved 12 April 2010.. ... Koleske, J. V. (1995). Paint and Coating Testing Manual. ASTM International. p. 232. ISBN 978-0-8031-2060-0. .. ... Koleske, J. V. (1995). Paint and Coating Testing Manual. ASTM International. p. 229. ISBN 978-0-8031-2060-0. .. ...
Ketone
ToxicityEdit. Although it is difficult to generalize on the toxicity of such a broad class of compounds, simple ketones are, in ... Qualitative organic testsEdit. Ketones give positive results in Brady's test, the reaction with 2,4-dinitrophenylhydrazine to ... Methyl ketones give positive results for the iodoform test.[8] Ketones also give positive results when treated with ...
Indinavir
They started to test L-735,524 on animals a couple months later and found that it was safe for animals. Consequently, the ... However, it failed safety assessments because of its toxicity.[11] Seeing that the research on their drug was heading in the ... "High bilirubin levels: Meaning, symptoms, and tests". Medical News Today. Retrieved 2018-10-21 ...
Alternative medicine
... "set of practices that cannot be tested, refuse to be tested, or consistently fail tests."[192] Dawkins argued that if a ... Dasgupta, Amitava; Hammett-Stabler, Catherine A (2011). Herbal Supplements: Efficacy, Toxicity, Interactions with Western Drugs ... There are also reasons why a placebo treatment group may outperform a "no-treatment" group in a test which are not related to a ... A 2015 study of users in the United States also found elevated blood lead levels in 40 percent of those tested. Other concerns ...
Acne
Madan RK, Levitt J (April 2014). "A review of toxicity from topical salicylic acid preparations". Journal of the American ... she must have a confirmed negative pregnancy test and use an effective form of birth control.[20] In 2008, the United States ... flutamide has a risk of serious liver toxicity, and cases of death in women taking even low doses of the medication to treat ... iPledge requires the woman to have two negative pregnancy tests and to use two types of birth control for at least one month ...
Hematopoietic stem cell transplantation
People who would like to be tested for a specific family member or friend without joining any of the bone marrow registry data ... The injury of the mucosal lining of the mouth and throat is a common regimen-related toxicity following ablative HSCT regimens ... A compatible donor is found by doing additional HLA-testing from the blood of potential donors. The HLA genes fall in two ... banks may contact a private HLA testing laboratory and be tested with a mouth swab to see if they are a potential match.[20] A ...
Levothyroxine
... it is recommended that their TSH and free T4 levels be tested after six weeks to check that they are within normal range.[11] ... and tricyclic and tetracyclic antidepressants increase its toxicity. On the other hand, lithium can cause hyperthyroidism (but ... Repeat thyroid function tests should be done five weeks after the dosage is increased.[11] ... "Toxicity, Thyroid Hormone". WebMd. Archived from the original on 14 October 2008. Retrieved 31 October 2010 ...
Lyme disease
Laboratory testing[edit]. Tests for antibodies in the blood by ELISA and Western blot is the most widely used method for Lyme ... Dymond NL, Swift IM (June 2008). "Permethrin toxicity in cats: a retrospective study of 20 cases". Aust Vet J. 86 (6): 219-23. ... As all people with later-stage infection will have a positive antibody test, simple blood tests can exclude Lyme disease as a ... The CDC does not recommend urine antigen tests, PCR tests on urine, immunofluorescent staining for cell-wall-deficient forms of ...
Inhalation
Examples include pulmonary function testing (e.g. nitrogen washout test, diffusion capacity testing (carbon monoxide, helium, ...
Alkali metal
Various tests eliminated the possibility of the unknown element being thorium, radium, lead, bismuth, or thallium. The new ... Johnson, Garland T.; Lewis, Trent R.; Wagner, D. Wagner (1975). "Acute toxicity of cesium and rubidium compounds". Toxicology ... Flame test colour. Principal emission/absorption wavelength (nm) Crimson. 670.8. Yellow. 589.2. Violet. 766.5. Red-violet. ... Indeed, these flame test colours are the most common way of identifying them since all their salts with common ions are soluble ...
Activated carbon
Research is being done testing various activated carbons' ability to store natural gas[1][2] and hydrogen gas.[1][2] The porous ... Tests of adsorption behaviour are usually done with nitrogen gas at 77 K under high vacuum, but in everyday terms activated ... The iodine capacity, mg/g, (ASTM D28 Standard Method test) may be used as an indication of total surface area. ... ASTM (D2866 Standard Method test) is used to determine the ash content of activated carbon. ...
Cellulose insulation
Low toxicity and environmental impact of raw materials[edit]. The non-recycled components of cellulose insulation are still ... Fire Resistance Tests on Cellulose and Glass Fiber Insulated Wood Stud Shear Walls, Kodur, V.K.R.; Sultan, M.A.; Latour, J.C.; ... Once tested, registration with the EPA as a pesticide is required before a product may be touted as having pesticidal ... Proper testing of products containing borates must be performed in order to determine whether dosage and presentation are ...
Moclobemide
Chronic toxicity: In an 18-months-study in rats with 10 mg/kg no signs of chronic toxicity were noted, with 50 mg/kg and 250 mg ... A dexamethasone suppression test (DST) and plasma and urine methoxyhydroxyphenylglycol (MHPG) test can be used to estimate who ... Studies in dogs revealed no toxicity relevant for humans. No evidence for a possible hepatic or cardiovascular toxicity was ... it was then tested for anti-cholinergic properties to see if it was a possible antidepressant but these tests also proved ...
Methanol fuel
Toxicity[edit]. Main article: Methanol Toxicity. Methanol occurs naturally in the human body and in some fruits, but is ... following a pilot test set up by a group of scientists involving blending gasoline with methanol between 1989 and 1992. The ... While methanol offers somewhat different toxicity exposure pathways, the effective toxicity is no worse than those of benzene ... However, for optimizing engine performance, fuel availability, toxicity and political advantage, a blend of ethanol, methanol ...
Materials science
... also provides a test for theories in condensed matter physics. ... "Nanomaterials and Nanoparticles: Sources and Toxicity". Biointerphases. 2 (4): MR17-MR71. arXiv:0801.3280. doi:10.1116/ ...
Invasive species
... toxicity, monitoring and impacts on ecosystem health". Harmful Algae. 14: 271-300. doi:10.1016/j.hal.2011.10.025. hdl:1912/5118 ... whereby ships loaded with cargo when they reached the Seaway were not tested because their ballast water tanks were empty. ... and possible heavy metal toxicity. Plant populations on these soils tend to show low density, but goatgrass can form dense ...
Visual impairment
A 2008 study tested the effect of using gene therapy to help restore the sight of patients with a rare form of inherited ... and the onset of toxicity is delayed. Methanol is commonly found in methylated spirits, denatured ethyl alcohol, to avoid ... A typical Snellen chart that is frequently used for visual acuity testing. ...
Mineral (nutrient)
zinc toxicity Manganese 00002.3002.3 11; NE Trace A cofactor in enzyme functions Grains, legumes, seeds, nuts, leafy vegetables ... Reference ranges for blood tests, sorted logarithmically by mass above the scale and by molarity below. ... Chromium toxicity Molybdenum 00000.0450.045 2; 0.6 Trace The oxidases xanthine oxidase, aldehyde oxidase, and sulfite oxidase[ ... molybdenum toxicity[32] Selenium 00000.0550.055 0.4; 0.3 Trace Essential to activity of antioxidant enzymes like glutathione ...
Potassium dichromate - Simple English Wikipedia, the free encyclopedia
It can be used in photography and to test for certain metals. It can be used to treat wood. ... It can be reacted with iron(II) sulfate to detoxify (remove the toxicity of) it. ...
Aquarius Reef Base
During NEEMO missions in Aquarius, the aquanauts are able to simulate living on a spacecraft and test spacewalk techniques for ... Oxygen toxicity. *Seasickness. *Uncontrolled decompression. *Diver behaviour and competence *Lack of competence ...
Bioluminescence - Simple English Wikipedia, the free encyclopedia
If you go into a hospital and have a blood test which measures viral proteins, cancer proteins, hormones, vitamins, bacterial ... As well as possibly warning predators about their toxicity, it is thought the main purpose of their flashing abdomen is to ...
Toxoplasma gondii - Viquipèdia, l'enciclopèdia lliure
Si H, Xu C, Zhang J, Zhang X, et al «Licochalcone A: An effective and low-toxicity compound against Toxoplasma gondii in vitro ... Reiter-Owona I, Petersen E, Joynson D, Aspöck H, et al «The past and present role of the Sabin-Feldman dye test in the ... Lykins J, Li X, Levigne P, Zhou Y, et al «Rapid, inexpensive, fingerstick, whole-blood, sensitive, specific, point-of-care test ... S'ha assajat un nou test que utilitza la tècnica d'immunocromatrografia de flux lateral per identificar d'una forma ràpida, ...
Spirometry
Related tests[edit]. Spirometry can also be part of a bronchial challenge test, used to determine bronchial hyperresponsiveness ... This is commonly referred to as a reversibility test, or a post bronchodilator test (Post BD), and is an important part in ... The tracer gas is analyzed simultaneously with CO to determine the distribution of the test gas mixture. This test will pick up ... During the test the person inhales a test gas mixture that consisting of regular air that includes a inert tracer gas and CO, ...
Ionic liquid
... s' aquatic toxicity is as severe as or more so than many current solvents.[62][63][64] Mortality isn't necessarily ... Some ionic liquids have been shown to reduce friction and wear in basic tribological testing,[57][58][59][60] and their polar ... D. Zhao; Y. Liao & Z. Zhang (2007). "Toxicity of Ionic Liquids". CLEAN - Soil, Air, Water. 35 (1): 42-48. doi:10.1002/clen. ... C Pretti; C Chiappe; D Pieraccini; M Gregori; F Abramo; G Monni & L Intorre (2006). "Acute toxicity of ionic liquids to the ...
Strychnine - Simple English Wikipedia, the free encyclopedia
It can act as a stimulant, much like caffeine, and is on the list of substances tested for doping in sports.[2] It was used as ... Because of its high toxicity and tendency to cause convulsions, the use of strychnine in medicine was eventually abandoned once ...
Index of HIV/AIDS-related articles
... liver function test (LFT) - long terminal repeat sequence (LTR) - long-term nonprogressors - LTR - lumbar - lumbar puncture - ... mitochondrial toxicity - molecule - molluscum contagiosum - monocyte - mononeuritis multiplex (MM) - monovalent vaccine - ... histocompatibility testing - histoplasmosis - HIV disease - HIV prevention trials network (HPTN) - HIV set point - HIV vaccine ... PPD test - pre-conception counseling - preclinical - precursor cells - prevalence - primary HIV infection - primary isolate - ...
White blood cell
Neutropenia can be acquired or intrinsic.[16] A decrease in levels of neutrophils on lab tests is due to either decreased ... so an individual may have symptoms of medication overdose or toxicity. Treatment is also aimed at the underlying cause of the ... Reference ranges for blood tests specify the typical counts in healthy people. ...
Yohimbine
"Yohimbine Test Ligand Search". PDSP Ki Database.. *^ a b Arthur JM, Casañas SJ, Raymond JR (June 1993). "Partial agonist ... especially regarding subchronic toxicity, genotoxicity and reproductive toxicity. ... "Drug Testing and Analysis. 8 (3-4): 357-69. doi:10.1002/dta.1849. PMID 26391406.. ... Drug Testing and Analysis. 8 (3-4): 357-69. doi:10.1002/dta.1849. PMID 26391406.. ...
Acute inhalation injury
Test articles passing muster in vitro can be evaluated in a number of in vivo models (usually in mice) of ALI including ... The direct toxicity to the cells leads to an increase in capillary permeability. Furthermore, when phosgene hydrolyzes it forms ... 2007) Breath tests and airway gas exchange. Pulm Pharmacol Ther. 20:112-7. Luh SP, Chiang CH. (2007) Acute lung injury/acute ... 2011) Sulfur mustard toxicity: history, chemistry, pharmacokinetics, and pharmacodynamics. Crit Rev Toxicol. 41:384-403. ...
2,4,5-Trichlorophenoxyacetic acid
2,4,5-T - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information ... early production facilities lacked proper temperature controls and individual batches tested later were found to have as much ... starting in the late 1970s due to toxicity concerns. Agent Orange, a defoliant used by the British in the Malayan Emergency and ...
What tests are performed in the workup of vitamin toxicity?
Drugs & Diseases , Emergency Medicine , Vitamin Toxicity Q&A What tests are performed in the workup of vitamin toxicity?. ... Vitamin D Toxicity in Young Breastfed Infants: Report of 2 Cases. Glob Pediatr Health. 2017. 4:2333794X17731695. [Medline]. [ ... Miksad R, de Lédinghen V, McDougall C, Fiel I, Rosenberg H. Hepatic hydrothorax associated with vitamin a toxicity. J Clin ... On the association between low resting heart rate and chronic aggression: retinoid toxicity hypothesis. Prog ...
Asbestos Toxicity: Clinical Assessment - Tests | Environmental Medicine | ATSDR
Pulmonary function tests.. Other tests and procedures that are sometimes used to diagnose asbestos-associated diseases by ... Screening Pulmonary Function Tests. Screening pulmonary function tests are useful for finding restrictive deficits most ... Pulmonary Function Test Results Associated with Asbestos-related Diseases. Asbestos-Associated Disease. Findings. ... Other tests that can be useful include BAL, lung biopsy, and colon cancer screening. ...
Methamphetamine Toxicity Workup: Laboratory Studies, Imaging Studies, Other Tests
Methamphetamine Toxicity Workup. Updated: Dec 26, 2017 * Author: John R Richards, MD, FAAEM; Chief Editor: Jeter (Jay) ... Methamphetamine toxicity and messengers of death. Brain Res Rev. 2009 May. 60(2):379-407. [Medline]. [Full Text]. ... Other Tests. Obtain an electrocardiogram for patients with chest pain, altered mental status, and tachycardia. ... Methamphetamine toxicity: treatment with a benzodiazepine versus a butyrophenone. Eur J Emerg Med. 1997 Sep. 4(3):130-5. [ ...
MDMA Toxicity Workup: Approach Considerations, Imaging Studies, Other Tests
MDMA Toxicity Workup. Updated: Dec 20, 2017 * Author: In-Hei Hahn, MD, FACEP, FACMT; Chief Editor: Jeter (Jay) Pritchard Taylor ... Send cultures of blood and urine for testing if signs of infection and fever are present. Consider lumbar puncture to exclude ... Burgess C, ODonohoe A, Gill M. Agony and ecstasy: a review of MDMA effects and toxicity. Eur Psychiatry. 2000 Aug. 15(5):287- ... encoded search term (MDMA%20Toxicity) and MDMA Toxicity What to Read Next on Medscape. Medscape Consult. ...
Cadmium Toxicity: Clinical Assessment - Laboratory Tests | Environmental Medicine | ATSDR
... there are medical tests that can measure exposure and cadmium body burden as well as standard and specialized clinical tests to ... Tests that should be performed if cadmium inhalation is suspected.. *Chest X-ray - looking for chemical pneumonitis and ... he following tests have been used to screen for renal damage in workers occupationally exposed to high cadmium levels and, ... Evaluation for chronic cadmium exposure may also include a complete blood count to check for anemia and liver function tests. ...
toxicity testing Market Research
Smoke & Toxicity Testing | SwRI
Standard tests and customized tests are available to help our clients meet their needs. For questions about this testing, ... We offer smoke and toxicity tests in accordance with a variety of standard procedures. ... We offer smoke and toxicity tests in accordance with a variety of standard procedures. Standard and customized tests are ... Smoke & Toxicity Test Capabilities. *Smoke density (specific optical density, DS) and mass loss measurements ...
After Fatal Toxicity, Questions Over DPD Testing Before Chemo
... a lawsuit has been filed in France because oncologists did not test for an enzyme deficiency before starting treatment. We ask ... No Testing in US So for now, it would seem that in the United States, there is no routine DPD testing, and the experts ... While a laboratory test is available to determine the UGT1A1 status of patients, "no one does that test either or very few ... Cite this: After Fatal Toxicity, Questions Over DPD Testing Before Chemo - Medscape - Mar 13, 2019. ...
New Approaches and Alternatives for Toxicity Testing - Superfund Research Program
... and Ecotoxicity Testing New Approaches and Alternatives for Toxicity, Fate and Transport, and Ecotoxicity Testing ... Session I - Toxicity Testing Strategies and Model Systems. May 14, 2018 • 1:00 - 3:00 p.m. EDT. To view an archive, visit EPAs ... In the first session, speakers provided an overview of toxicity testing strategies to advance the use of 21st-century science ... discussed the use of zebrafish for toxicity testing and its ability to help advance 21st-century science. She presented a ...
Browse subject: Toxicity testing | The Online Books Page
Toxicological testing. Filed under: Toxicity testing*. Toxicity Testing: Strategies to Determine Needs and Priorities. , by ... Filed under: Toxicity testing -- United States*. Toxicity Testing: Strategies to Determine Needs and Priorities. , by National ... Toxicity testing (Include extended shelves). You can also browse an alphabetical list from this subject or from: Toxicity ... Filed under: Alternative toxicity testing -- Moral and ethical aspects*. Science, Medicine, and Animals: A Circle of Discovery ...
New Tox21 Robot Will Test Chemical Toxicity - Environmental Leader
New Tox21 Robot Will Test Chemical Toxicity. March 11, 2011. March 11, 2011. by Paul Nastu. ... Testing results will provide information useful for evaluating if these chemicals have the potential to disrupt human body ... In November, it was announced that the U.S. EPA ToxCast screening program had screened 1,000 chemicals for potential toxicity ... agencies have unveiled a new high-speed robot screening system that will test 10,000 different chemicals for potential toxicity ...
A new approach to practical acute toxicity testing | SpringerLink
A method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD50, is ... Bass R, Günzel P, Henschler D, König J, Lorke D, Neubert D, Schütz E, Schuppan D, Zbinden G (1982) LD50 Versus Acute Toxicity, ... A method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD50, is ... Trevan JW (1927) The error of determination of toxicity. Proc R Soc (London) Ser. B. 101: 483-514Google Scholar ...
Antioxidant, Antimicrobial Activity and Toxicity Test of Pilea microphylla
... and including toxicity test. Antioxidant activity were tested by using DPPH free radical scavenging, also total phenolic ... Toxicity assay carried out by using brine shrimps. Methanol extract of method I (ME I) showed the highest antioxidant activity ... extract was tested in vitro by using disc diffusion method and minimum inhibitory concentration (MIC). The ,i,Pilea microphylla ... A total of 9 plant extracts were tested, using two different kinds of extracting methods to evaluate the antioxidant and ...
Toxicity Test Kit Articles on Environmental XPRT
Find toxicity test kit articles on Environmental XPRT, the worlds largest environmental industry marketplace and information ... toxicity test kit Articles. Related terms for "toxicity test kit ": toxicity test articles , test kit articles , acute toxicity ... The proposed toxicity test is based on the respirometric characteristics of the bacteria according to the principals of ... Development of Water Quality Test Kit Based on Substrate Utilization and Toxicity Resistance in River Microbial Communities ...
Genetic Toxicity Test Articles on Environmental XPRT
Find genetic toxicity test articles on Environmental XPRT, the worlds largest environmental industry marketplace and ... genetic toxicity test Articles. Related terms for "genetic toxicity test ": toxicity test articles , genetic toxicity articles ... Optimization of culturing conditions for toxicity testing with the alga Oophila sp. (Chlorophyceae), an amphibian endosymbiont ... The strain of Hyalella azteca (Saussure: Amphipoda) commonly used for aquatic toxicity testing in the US has been shown to ...
Ocular Toxicity Test Method Evaluations
Pyrogen Tests Ocular Toxicity Test Method Evaluations. Ocular toxicity testing, one of the four most commonly conducted product ... OptiSafe Test Method. OptiSafe is an in vitro test method in which a test substance is applied to a semipermeable membrane. ... Short Time Exposure Test The short time exposure (STE) test is an in vitro test proposed for identifying ocular irritants. ... Despite progress in alternative ocular toxicity test method development, no alternative test method has been adopted by ...
New Guidelines for Toxicity Testing of Oligonucleotide Drugs
When it comes to testing their potential to cause reproductive and developmental harm, oligonucleotide-based therapeutics ... Drug Toxicity. Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, ... New consensus guidelines for toxicity testing that take into consideration the combined chemical and biological characteristics ... When it comes to testing their potential to cause reproductive and developmental harm, oligonucleotide-based therapeutics ...
CN Bio to Provide Drug Metabolism and Safety Toxicity Testing Services | Business Wire
CN Bio to Provide Drug Metabolism and Safety Toxicity Testing Services Extended range of services supports accelerated drug ... Through our enhanced drug metabolism and safety toxicity testing services, we enable scientists to take a step beyond what is ... today announced the commercial launch of its Drug Metabolism and Safety Toxicity Testing Services. Liver toxicity is a ... and safety toxicity testing, to provide in-depth analysis of acute or chronic drug-induced liver injury using a wide range of ...
Monsanto Hides Toxicity Test Results on RoundUp, Calling them 'Commercial' Secret
The test was meant to be an acute exposure toxicity test in which rats were given RoundUp by mouth for several days, and ... Monsanto Hides Toxicity Test Results on RoundUp, Calling them Commercial Secret. Talking about Monsantos latest attempt to ... Meanwhile, additional toxicity tests conducted on glyphosate - the main ingredient in RoundUp - have been conducted in Europe, ... Furthermore, why would China give Monsanto permission to export RoundUp into their country based on toxicity tests that only ...
Toxicity Tests | Harvard Catalyst Profiles | Harvard Catalyst
"Toxicity Tests" by people in Harvard Catalyst Profiles by year, and whether "Toxicity Tests" was a major or minor topic of ... An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods ... "Toxicity Tests" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Toxicity Tests" by people in Profiles. ...
Countries Unite to Reduce Animal Testing for Product Toxicity
... today signed a memorandum of cooperation that could reduce the number of animals required for consumer product safety testing ... and reduced-animal toxicity testing methods. If the toxicity testing methods are shown to be reproducible based on strong ... Alternative test methods are those that accomplish one or more of the 3Rs - reducing the number of animals used in testing, or ... Countries Unite to Reduce Animal Testing for Product Toxicity. By National Institutes of Health ...
EPA Considering New Toxicity Testing for BPA -- Environmental Protection
... is requesting public comment on possible toxicity testing and environmental sampling to study BPAs potential environmental ... EPA Considering New Toxicity Testing for BPA. *Jul 27, 2011. Following a BPA Action Plan announced in March 2010, the U.S. ... Environmental Protection Agency (EPA) is requesting public comment on possible toxicity testing and environmental sampling to ... "The data collected under the testing EPA is considering would help EPA better understand and address the potential ...
Acute toxicity testing (Monitoring and Testing) Articles | Environmental XPRT
... monitoring and testing) articles , the worlds largest environmental industry marketplace and information resource. ... The acute toxicity of major ion salts to Ceriodaphnia dubia: I. Influence of background water chemistry The ions Na+, K+, Ca2+ ... Toxicity and biofilm-based selection for methyl tert-butyl ether bioremediation technology Extractive membrane biofilm reactor ... Effects of silver nanoparticles to the freshwater snail Physa acuta: The role of test media and snails life cycle stage Silver ...
Alternative Approaches for Acute Inhalation Toxicity Testing
Currently accepted guidelines for inhalation toxicity tests share core principles. These inform both essential testing needs to ... Acute systemic toxicity tests identify chemicals that could cause illness or death after a single exposure. Webinars in this ... Additivity approaches may be useful for estimating toxicity of mixtures.. *A variety of available alternative test methods can ... Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements ...
acute toxicity tests
Tags : acute toxicity tests, Additive, Antagonism, Aquatic organisms, baseline toxicity, chemical mixtures, chemical monitoring ... TR 080 - Aquatic Toxicity of Mixtures. TR 080 : Aquatic Toxicity of Mixtures , July 2001 The inherent toxicity of a substance ... ecosystems, Ecotoxicology, inherent toxicity, metal toxicity, Mixtures, model ecosystems, narcosis, physical chemical, PNEC, ...
APPENDIXES | Toxicity Testing: Strategies to Determine Needs and Priorities | The National Academies Press
Level II testing consists of toxicity tests that are intermediate between acute tests and subahronic feeding studies, whereas ... short-term test; LT = long-term test. 338 ST Low exposure and low toxicity Anything but low exposure and low toxicity ST LT ... Medium toxicity; ST or low toxicity and medium exposure Low toxicity None and low exposu re Low High Dossier High toxicity LT ... High toxicity; or LT high exposure and medium toxicity Otherwise ST High toxicity; or LT high exposure and medium toxicity ...
NIOSHTIC-2 Publications Search - 20033962 - Workshop report: chronic inhalation toxicity and carcinogenicity testing of...
... a workshop on chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles was held in Chapel Hill, ... On May 8-10, 1995, a workshop on chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles was ... Workshop report: chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles.. ... For instance, it was recommended that along with other information (decrease in body weight, systemic toxicity, etc.), data ...
Early Toxicity Testing Market to increase steadily by 2014-2022 | Medgadget
... where the toxicity of the compounds present in the test product is evaluated. Different tests are conducted to check the ... Some tests are also useful to check if the entity has toxic ... Early toxicity testing is used during clinical trials, ... Early toxicity testing is used during clinical trials, where the toxicity of the compounds present in the test product is ... However, limited awareness about the benefits of early toxicity testing and limitations of preclinical testing are expected to ...
The Future of Developmental Toxicity Testing | Publications | Knowledge | Exponent
John M. DeSesso recently authored an opinion that explores the future of developmental toxicity testing and how this will ... To this end, the standard safety test design for this type of endpoint was developed in the mid-1960s and has changed little ... John M. DeSesso recently authored an opinion that explores the future of developmental toxicity testing and how this will ... As a result, for at least the next few decades, the pregnant mammal will remain the final linchpin in teratology testing.. How ...
Potential toxicityAssessmentSystemic toxicityAquaticOcular toxicityChemicalsAssays2017EndpointsToxicologyCarcinogenicityNanomaterialsExposureToxicLong-term toxicityNanomaterial toxicityCompoundsLaboratoryGenotoxicityAssayVivoEvaluationApproachesOrganismsSubstancesClinicalWhole effluent toxicitySedimentZebrafishFindingsPredictiveChronic toxicity testsDevelopmentalAcute inhalation toxicityToxicologicalRefineWorkup2016MethodsDetermine the toxicitySuitable for toxicityConcentrationsRatsEndpointPredictEffluentsLiver toxicityBiological toxicitySilicoChemicalDrug Toxicity
Potential toxicity9
- Several federal agencies have unveiled a new high-speed robot screening system that will test 10,000 different chemicals for potential toxicity. (environmentalleader.com)
- Tox21 has already screened more than 2,500 chemicals for potential toxicity using robots and other chemical screening technologies. (environmentalleader.com)
- In November, it was announced that the U.S. EPA ToxCast screening program had screened 1,000 chemicals for potential toxicity to people and the environment. (environmentalleader.com)
- Screening for potential toxicity as early as possible may help you select the relevant lead candidates to advance in the drug development process. (stemcell.com)
- Produced using time-lapse photography, this video shows a new high-speed robot screening system being built that will test 10,000 different chemicals for potential toxicity. (genome.gov)
- Bethesda, Md. , Thurs., March 10, 2011 - Several federal agencies, including the National Institutes of Health, today unveiled a new high-speed robot screening system that will test 10,000 different chemicals for potential toxicity. (genome.gov)
- Identifying potential toxicity at an early stage during drug discovery can save both time and development costs and, most importantly, reduce the likelihood of late stage failure. (miltenyibiotec.com)
- The fact is that today there is no obligation to assess the potential toxicity of volatile products (deodorant, fragrance, etc…), and when testing is done, it usually involves laboratory animals whose respiratory system is far different from the human one. (proanima.fr)
- To assess the potential toxicity of airborne particles, progress has been made to develop air-liquid interface (ALI) exposure systems 1 , 2 , 3 , 4 , 5 . (jove.com)
Assessment25
- In addition to laboratory studies, imaging and electrocardiographic studies can be used in the assessment of patients with vitamin toxicity. (medscape.com)
- For further assessment of whether a patient has a restrictive abnormality and asbestosis, additional, more specialized tests may be required. (cdc.gov)
- The study evaluated the safety of reclaimed water using health risk assessment and biotoxicity tests. (environmental-expert.com)
- The present study examined how transcriptomics tools can be included in a Triad‐based soil quality assessment to assess the toxicity of soils from river banks polluted by metals. (environmental-expert.com)
- The authors summarize the findings of the Reproductive Subcommittee of the Oligonucleotide Safety Working Group (OSWG) in the article "Considerations for Assessment of Reproductive and Developmental Toxicity of Oligonucleotide-Based Therapeutics. (medindia.net)
- Meanwhile, additional toxicity tests conducted on glyphosate - the main ingredient in RoundUp - have been conducted in Europe, and by the Brussels-based advisor to NGOs on toxicity and risk assessment issues, Tony Tweedale has asked the European Food Safety Authority (EFSA) to disclose two more of these studies to the general public. (infowars.com)
- Integrated approaches to testing and assessment will be needed to use these systems in ways that address the breadth of mechanisms, ensure good coverage of the relevant chemical landscape, and leverage the collective strengths of these methods and complementary non-testing approaches. (nih.gov)
- This includes interpreting study data relative to children's health and developmental and reproductive toxicity for standard-setting and risk/safety assessment, screening assays for endocrine disruptors, quantitative benchmark dose analysis and risk assessment, and designing and interpreting mechanistic studies to address potential susceptibility in human fetuses and infants. (exponent.com)
- Large-Scale Assessment of the Zebrafish Embryo as a Possible Predictive Model in Toxicity Testing. (nc3rs.org.uk)
- ZeGlobalTox have created a new genetically modified line of zebrafish to drive the expression of unique fluorescent proteins in the three main organs (brain, heart and liver) enabling assessment of acute multi-organ toxicity and teratogenicity in the same animal. (nc3rs.org.uk)
- Assessment of acute toxicity, i.e. (nc3rs.org.uk)
- Over the years, researchers have attempted to use in vitro assessment of nanomaterial toxicity to predict in vivo outcomes. (nanowerk.com)
- The forensic toxicologists at The Forensic Panel possess the expertise from years of experience and leadership in their forensic science fields to examine the methodology of drug and chemical assessment and toxicity testing. (forensicpanel.com)
- The long-term vision is to include this in vitro test in a battery of in silico and in vitro assays that can be used in an integrated testing strategy, providing comprehensive information on biological endpoints relevant to inhalation exposure to nanomaterials to be used in the hazard ranking of substances in the risk-assessment process. (nanowerk.com)
- However, all toxicity-testing procedures have certain limitations that must be considered in developing the methodology and applications of toxicity testing in any large-scale water-quality-assessment program. (usgs.gov)
- The safety assessment processes require the toxicity data of chemicals in multiple test species and thus, emphasize the need for computational methods capable of toxicity prediction in multiple test species. (rsc.org)
- Environmental toxicity information serves two roles in the assessment of a substance for environmental safety and regulatory requirements. (cefic-lri.org)
- For conventional risk assessment of single substances, these PECs would be compared to PNECs based on aquatic toxicity testing. (cefic-lri.org)
- The recent RIFM/ECETOC UVCB Workshop ( 02-04 November 2016, Florida, USA) highlighted the need to account for complex substance exposure and fate in order to perform more relevant toxicity testing, and raised questions on the impact this type of testing would have on risk assessment outcomes (Salvito and Galay-Burgos, 2017). (cefic-lri.org)
- Further development and validation of such test systems are crucial for evidence based safety evaluation and risk assessment of inhaled materials, nanomaterials and therapeutic products. (edu.au)
- Personal care product preservatives: risk assessment and mixture toxicities with an industrial wastewater. (semanticscholar.org)
- The vision of the H2020-supported EU-ToxRisk project is to drive the required paradigm shift in toxicological testing away from 'black box' animal testing towards a toxicological assessment based on human cell responses and a comprehensive mechanistic understanding of cause-consequence relationships of chemical adverse effects. (ifado.de)
- This allows the capture of relevant pharmacokinetics during the preclinical stages of testing, saving both time and resources by enabling the assessment of physiologically relevant human data early on. (ddw-online.com)
- Using a number of effective assessment tools, such as porter's five forces and value chain analysis, it performs in-depth analyses of the production and supply as well as the demand and sales of China in vitro toxicity testing market research report 2017 and provides deep insights into the future prospects of this market. (qyresearchreports.com)
- The issue of endocrine disruption has, in view of human risk assessment, raised the question on whether more sensitive test methods are needed to detect the reproductive toxic properties of xenobiotic compounds with endocrine properties. (openrepository.com)
Systemic toxicity8
- Acute systemic toxicity tests identify chemicals that could cause illness or death after a single exposure. (nih.gov)
- Webinars in this 2016 series explored and discussed alternative approaches that could replace, reduce, or refine the use of animals for identifying chemicals that may cause acute systemic toxicity when inhaled. (nih.gov)
- A variety of available alternative test methods can reliably identify potential cytotoxicants, but none can single-handedly assess the multiple mechanisms of acute systemic toxicity following inhalation exposure. (nih.gov)
- For instance, it was recommended that along with other information (decrease in body weight, systemic toxicity, etc.), data should be obtained on lung burdens and bronchoalveolar lavage fluid analysis to assist in establishing the chronic exposure levels. (cdc.gov)
- Some tests are also useful to check if the entity has toxic potentials such as genotoxicity, carcinogenicity, neurotoxicity, and systemic toxicity. (medgadget.com)
- Cosmetics and household products segment is the highest revenue contributor to this market owing to increase in adoption in various applications, such as to detect dermal toxicity, systemic toxicity, and ocular toxicity. (medgadget.com)
- Building upon 2015 workshops on inhalation toxicity testing of nanomaterials and acute systemic toxicity testing, the PETA International Science Consortium and the US NTP Interagency Center for the Evaluation of Alternative Toxicological Methods co-hosted a meeting and webinar series to address current practices for acute inhalation toxicity testing. (norecopa.no)
- The application segments are systemic toxicity, carcinogenicity, skin sensitization and irritation, neurotoxicity, dermal toxicity, ocular toxicity and organ toxicity The method segments includes biochemical, in silico methods and ex vivo model. (sbwire.com)
Aquatic16
- The strain of Hyalella azteca (Saussure: Amphipoda) commonly used for aquatic toxicity testing in the US has been shown to perform poorly in some standardized reconstituted waters frequently used for other test species. (environmental-expert.com)
- 5.3 Toxicity tests with rotifers of the genus Brachionus are more easily performed than with many other aquatic animals because of their rapid reproduction, short generation times, sensitivity ( 34 ) , and the commercial availability of rotifer cysts. (astm.org)
- Obtaining test animals from cysts greatly reduces some of the major problems in routine aquatic toxicological testing such as the limited availability of test animals and the inconsistency of sensitivity over time. (astm.org)
- The convenience of an off-the-shelf source of test animals that require no pre-conditioning is likely to permit new applications of aquatic toxicity tests. (astm.org)
- A Task Force set up by the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) has provided new insights into scientific testing for the impact of undissolved particles in the aquatic environment. (bionity.com)
- There are few studies known about the toxicity of acrylamide to aquatic organisms which have shown evidence of a number of histopathological effects. (scirp.org)
- 5.8 Results of three-brood toxicity tests with C. dubia might be an important consideration when assessing the hazards of materials to aquatic organisms (see Guide E1023 ), or when deriving water quality criteria for aquatic organisms. (astm.org)
- The primary goal of WET testing is to ensure that wastewater effluent discharged into Wisconsin surface waters do not negatively impact aquatic ecosystems. (wisc.edu)
- Receiving water (the water which the effluent is discharged into) is used as the dilution water in WET tests in order to simulate what actually happens in the aquatic environment when the effluent is introduced. (wisc.edu)
- Chronic tests estimate the concentration of effluent that interferes with the growth, development, and reproductive potential of aquatic organisms. (wisc.edu)
- Chronic tests predict the concentrations that interfere with normal growth, development and reproductive potential of these aquatic organisms. (wisc.edu)
- In this study, we have established local and global QSTR (quantitative structure-toxicity relationship) and ISC QSAAR (interspecies correlation quantitative structure activity-activity relationship) models for predicting the toxicities of pesticides in multiple aquatic test species using the toxicity data in crustacean ( Daphnia magna , Americamysis bahia , Gammarus fasciatus , and Penaeus duorarum ) and fish ( Oncorhynchus mykiss and Lepomis macrochirus ) species in accordance with the OECD guidelines. (rsc.org)
- The results suggest for the appropriateness of the developed QSTR/QSAAR models to reliably predict the aquatic toxicity of structurally diverse pesticides in multiple test species and can be used for the screening and prioritization of new pesticides. (rsc.org)
- Aquatic toxicity data for UVCBs can be generated from testing known individual components or testing water accommodated fractions (WAFs) generated from the whole substance. (cefic-lri.org)
- The equilibrium partitioning (EqP) method provides a framework for interpreting toxicity data in soil, sediment, and aquatic exposures. (cefic-lri.org)
- Application of EqP framework to extrapolate from aquatic toxicity data to the sediment compartment for very hydrophobic chemicals is limited by the lack of reliable empirical sediment toxicity data to validate this approach. (cefic-lri.org)
Ocular toxicity5
- Ocular toxicity testing, one of the four most commonly conducted product safety tests, is conducted to identify ocular corrosives (substances that cause permanent eye tissue damage) and ocular irritants (substances that cause temporary eye tissue damage). (nih.gov)
- NICEATM reviewed a validation study conducted by the OptiSafe test method developer, Lebrun Labs, and concluded that the study data indicated that the OptiSafe method compared favorably to other in vitro ocular toxicity testing methods. (nih.gov)
- In 2012, ICCVAM recommended a procedure based on this analysis that uses 50% to 83% fewer animals than accepted testing procedures and harmonizes the number of animals used for ocular toxicity testing across U.S. regulatory agencies and international test guidelines. (nih.gov)
- The workshop identified best practices for chemical and product ocular toxicity testing using methods and approaches that replace, reduce, and refine animal use. (nih.gov)
- Despite progress in alternative ocular toxicity test method development, no alternative test method has been adopted by regulatory authorities as a complete replacement for the in vivo rabbit eye test. (nih.gov)
Chemicals24
- Testing results will provide information useful for evaluating if these chemicals have the potential to disrupt human body processes enough to lead to adverse health effects. (environmentalleader.com)
- Methods for measuring toxicity or respiratory activity of microbial cultures can be used as tools for assessing the presence of chemicals and their impact on the streams. (environmental-expert.com)
- The center is integrating computing and information technologies with clinical and pathological endpoints to create a systems-modeling approach to predict toxicity of new chemicals and nanomaterials. (uml.edu)
- 1.1 This guide describes procedures for obtaining laboratory data concerning the acute toxicity of chemicals and aqueous effluents released into fresh, estuarine, or marine waters. (astm.org)
- Because natural conditions in the environment, such as temperature, can significantly affect the toxicity of pollutant chemicals on living organisms, the effects of pollutants can differ according to region. (enviweb.cz)
- The analysis demonstrated that interactions between pollutants and environmental conditions were widespread, but affected the toxicity of chemicals in unpredictable ways. (enviweb.cz)
- Which means that many chemicals which are now considered to be "non-toxic", in various regards, may have effects completely undetected by the most-commonly used toxicity tests. (planetsave.com)
- Abstract Toxicity testing is essential for the protection of human health from exposure to toxic environmental chemicals. (bionity.com)
- The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. (oecd-ilibrary.org)
- A major task of the forensic toxicologist is toxicity testing and the identification of toxicants, such as chemicals, drugs, and poisons, in biological material. (forensicpanel.com)
- The system marks the beginning of a new phase of an ongoing collaboration, referred to as Tox21, that is working to protect human health by improving how chemicals are tested in the United States. (genome.gov)
- Tox21 merges existing agency resources (research, funding, and testing tools) to develop ways to more effectively predict how chemicals will affect human health and the environment. (genome.gov)
- A thorough analysis and prioritization process from more than 200 public databases of chemicals and drugs used in the United States and abroad was conducted to select the initial 10,000 chemicals for testing. (genome.gov)
- The addition of this new robot system will allow the National Toxicology Program to advance its mission of testing chemicals smarter, better, and faster," said Linda Birnbaum, Ph.D., NIEHS and NTP director. (genome.gov)
- In a TIE, effluent samples are manipulated to remove suspect chemicals and then re-tested to see if toxicity remains. (wisc.edu)
- To test whether chemicals are toxic to humans, researchers need to use liver cells that have been freshly harvested from mice or other mammals. (bio-medicine.org)
- They write: "We believe that the MMH-GH cell lines provide a cheap, reproducible, rapid, reliable and ethically acceptable tool," for assessing the toxicity of chemicals. (bio-medicine.org)
- These low concentrations of the chemicals would not have been picked up by current toxicity-testing methods, which brand a chemical as 'toxic' only if it kills liver cells. (bio-medicine.org)
- Recent innovations in human cell culture exposure and test systems has allowed the development ofin vitro assay systems that are predictive, representative and suitable for toxicity screening of a diverse range of chemicals including airborne materials and nanomaterials (NMs). (edu.au)
- Sediment toxicity testing is often required under international chemicals management regulations, but it is challenging to select appropriate test methodologies/parameters to obtain reliable and meaningful results for very hydrophobic chemicals. (cefic-lri.org)
- Tests are usually performed at very elevated concentrations exceeding the sorptive capacity of the media and without proper equilibration of dosed sediment phase and water phase, and it is difficult to obtain homogeneous distribution of the tested chemicals in sediment. (cefic-lri.org)
- The objective of this project is to develop additional guidance on sediment toxicity testing methods for very hydrophobic chemicals in sediments that ensure reproducibility and realism in the test results to support product risk assessments [ 2 ]. (cefic-lri.org)
- Testing should characterise the impact of study design parameters on toxicity results for very hydrophobic chemicals. (cefic-lri.org)
- Corrosive chemicals possess physical toxicity because they destroy tissues, but they're not directly poisonous unless they interfere directly with biological activity. (wikipedia.org)
Assays12
- Based on the type of assay used, in vitro technique is further divided into enzyme toxicity assays, bacterial toxicity assays, cell-based ELISA and western blots, tissues culture assays, receptor binding assays, and other assays. (medgadget.com)
- The new strategy for chemical toxicity testing and modeling is to use in vitro human cell-based assays in conjunction with quantitative high-throughput screening (qHTS) technology, to identify molecular mechanisms and predict in vivo responses. (bionity.com)
- This type of lineage-specific toxicity cannot be determined using in vitro assays, such as the colony-forming unit granulocyte/macrophage (CFU-GM) assay. (taconic.com)
- Although single organ specific toxicity assays have already been commercialised, it is not yet possible to assess toxicity in the three main organs (brain, heart and liver) in the same animal. (nc3rs.org.uk)
- In this webinar, you'll learn from hematopoietic expert Dr. Jackie Damen about the importance of hematotoxicity testing in drug development and how hematopoietic colony forming unit (CFU) assays can be applied in toxicity testing to assist in the successful screening of your small molecule compounds and biologics. (stemcell.com)
- Addition of a preservative before freezing is recommended, when feasible, for specimens being tested for vitamin C. However, storage and transport requirements differ between laboratories and assays. (arupconsult.com)
- Many commonly used laboratory tests (including thyroid hormone assays and other immunoassays) make use of biotin-streptavidin technology. (arupconsult.com)
- High biotin intake, such as from biotin supplements, may interfere with these assays, leading to inaccurate test results. (arupconsult.com)
- They pin big hopes on high-throughput human cell-based assays that would replace slow and costly in vivo animal studies for evaluating chemical toxicity. (acs.org)
- The assays segment is further classified as a cell based ELISA and western blots, bacterial toxicity assay, enzyme toxicity assay, receptor binding assay and tissue culture assay. (sbwire.com)
- Hepatocytes are used in plated formats when drugs are poorly metabolised in short-term suspension assays, or when mechanistic data regarding drug-drug interactions and mechanistic toxicity is needed. (ddw-online.com)
- Despite a strong need both from authorities and consumers, to date there is no efficient assays to evaluate the short and long term toxicity of the electronic cigarette (e‑cigarette). (proanima.fr)
20179
- In the recent times, the global market for China in vitro toxicity testing market research report 2017 has surfaced as one of the most promising markets in the pharmaceutical industry, thanks to the significant rise in research and development activities by leading vendors of China in vitro toxicity testing market research report 2017 across the world. (qyresearchreports.com)
- Manufacturers have turned to technological innovations and data-driven customization to satisfy the augmenting consumer demand for efficiency and more accuracy in results, leading to an increased usage of technology in the China in vitro toxicity testing market research report 2017 production processes, which is also reflecting positively on the growth of this market. (qyresearchreports.com)
- The research report on the China in vitro toxicity testing market research report 2017 is an analytical study which comprehensively analyzes the competitive framework of this market. (qyresearchreports.com)
- The study begins with a detailed overview of the market for China in vitro toxicity testing market research report 2017, including the definition, classification, and industry chain structure of China in vitro toxicity testing market research report 2017, and move forward to cover every aspect of this market, counting several criteria based on which the market is classified. (qyresearchreports.com)
- With chemical industry undergoing a phase of technological disruption, innovations in products are likely to shape the future of the China in vitro toxicity testing market research report 2017. (qyresearchreports.com)
- Further, it offers an estimation of the market size in terms of value (US$) and in volume (kilo tons) and talks about the key segments and the geographical subdivisions of the market for China in vitro toxicity testing market research report 2017 in details. (qyresearchreports.com)
- It provides in-depth information on the development trends and the policies and regulations, concerning China in vitro toxicity testing market research report 2017, implemented in each of the geographical segments. (qyresearchreports.com)
- The predominant applications of the China in vitro toxicity testing market research report 2017 have also been discussed at length in this research study. (qyresearchreports.com)
- With all these analyses and information, this report can act as a valuable guide to readers looking to gain a clear understanding of all the factors that are influencing the market for China in vitro toxicity testing market research report 2017 at present and are projected to remain doing so over the forecast period. (qyresearchreports.com)
Endpoints5
- A test method protocol describing specific procedures to prevent or minimize animal pain and distress is included in the ICCVAM report evaluating the use of anesthetics, analgesics, and humane endpoints during the in vivo eye test. (nih.gov)
- CN Bio's extended portfolio of services offers solutions to many existing workflow challenges including: drug metabolism testing, to study the human metabolism of lead candidates, identify metabolites and correlation with cell health - even for low clearance compounds, and safety toxicity testing, to provide in-depth analysis of acute or chronic drug-induced liver injury using a wide range of endpoints to determine causality and mechanism of toxicity. (businesswire.com)
- Then the possible impacts of the test chemical on the following measurement endpoints are assessed under controlled conditions: sex and total number of emerged adult flies, retardation of emergence indicated by the developmental rate and morphological change. (oecd.org)
- The goal of the workshop was to make specific recommendations on the design of this in vitro test, including cell types, endpoints, exposure systems, and dosimetry considerations required to develop the in vitro model. (nanowerk.com)
- Newer paradigms and metrics are evolving to bypass animal testing, while maintaining the concept of toxicity endpoints. (wikipedia.org)
Toxicology10
- Representatives from four international agencies, including the director of the U.S. National Toxicology Program (NTP), today signed a memorandum of cooperation that could reduce the number of animals required for consumer product safety testing worldwide. (opposingviews.com)
- Applications for humanized mice in preclinical toxicology testing are gaining traction, in particular for hematoxicity and cytokine release syndrome. (taconic.com)
- See Emergency Toxicology as an additional resource for testing information. (arupconsult.com)
- This 48-well microtiter plate assay, developed by the Environmental Toxicology staff, determines the short-term chronic toxicity of effluents to the freshwater alga Selenastrum capricornutum. (wisc.edu)
- The "product" is a package of services for: (1) testing and monitoring of nanomaterials that are discharged into the environment, (2) screening of new compounds before they are produced by industry, and (3) basic toxicology research. (epa.gov)
- Moreover, due to increase in the focus on reduction of drug development cost, ADME-Toxicology testing is projected to grow in the coming years. (sbwire.com)
- We are working on in vitro -systems to reduce animal testing", says Dr. Raymond Reif, leader of the 'Visualizing Toxicology' junior group at the IfADo. (ifado.de)
- All together, that project should result in the replacement of animals for e‑cigarette testing, and ultimately reduce the numbers of animals used for inhalation toxicology. (proanima.fr)
- We studied six known and alleged endocrine disruptors in an existing reproductive toxicology screening test to see if this test would score these compounds as reproductive toxicants. (openrepository.com)
- Examples of applied research include testing disease treatments, breeding, defense research and toxicology, including cosmetics testing. (wikipedia.org)
Carcinogenicity4
- Workshop report: chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles. (cdc.gov)
- On May 8-10, 1995, a workshop on chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles was held in Chapel Hill, North Carolina. (cdc.gov)
- Meanwhile, several short-termin vitroandin vivostudies that may be useful to assess the relative potential of fibrous substances to cause lung toxicity/carcinogenicity have been identified. (cdc.gov)
- Tests for chronic toxicity, including cumulative effects and for evidence of potential carcinogenicity, mutagenicity, and teratogenicity. (oup.com)
Nanomaterials6
- Sohal IS, O'Fallon KS, Gaines P, Demokritou P, Bello D. Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs. (harvard.edu)
- With little known about the toxicity of nanomaterials, predicting how particles might affect human health and the environment is necessary for the safe development of nano products. (uml.edu)
- The current infrastructure and funding for animal testing is insufficient to support the evaluation of all nanomaterials currently in existence, let alone those that will be developed in the near future. (nanowerk.com)
- One of the most common practices is to use the toxicity of nanomaterials in isolated cell cultures as a predictor of toxicity in similar cell types in the body. (nanowerk.com)
- Nanowerk News ) Today, the PETA International Science Consortium Ltd. put out a request for proposal (RFP) to identify facilities that can develop an in vitro test that, when used in an integrated approach, has the potential to replace the current test conducted on animals to assess the inhalation toxicity of nanomaterials. (nanowerk.com)
- This is an important development, and we believe microarrays and associated data analysis can be developed into the testing method for nanomaterials that the EPA seeks. (epa.gov)
Exposure28
- Therefore, there are medical tests that can measure exposure and cadmium body burden as well as standard and specialized clinical tests to measure the health effects of cadmium exposure. (cdc.gov)
- Evaluation for chronic cadmium exposure may also include a complete blood count to check for anemia and liver function tests. (cdc.gov)
- Urinary cadmium levels do not rise significantly after acute exposure and are not useful for testing in the acute setting. (cdc.gov)
- Because of the potential for sample contamination, hair levels are not reliable either as predictors of toxicity or as indicators of occupational exposure. (cdc.gov)
- The short time exposure (STE) test is an in vitro test proposed for identifying ocular irritants. (nih.gov)
- The test was meant to be an acute exposure toxicity test in which rats were given RoundUp by mouth for several days, and rabbits were exposed to RoundUp by skin. (infowars.com)
- One was a test by German regulatory agencies in which they measured an 'Acceptable Daily Intake' (ADI) of the chemical, and another measured chronic toxicity based on exposure. (infowars.com)
- Ecotoxicological testing should therefore include exposure of organisms to a variety of environmental conditions to fully represent conditions found in the natural environment. (enviweb.cz)
- The slow starvation effect observed under constant exposure to low levels of neonicotinoids is not detected by conventional toxicity tests, as they are not carried out over a period of several weeks. (planetsave.com)
- This method provides information on health hazard likely to arise from exposure to test substance via oral administration. (oecd-ilibrary.org)
- Signs and symptoms of toxicity correlate with route of exposure, specific element forms, and type of exposure, whether acute or chronic. (arupconsult.com)
- ARUP Laboratories offers element exposure testing for a variety of specimen types, as well as panel testing for common heavy metals. (arupconsult.com)
- At 500 mg/L, the highest test concentration, the survival of embryos was greatly reduced within 24 hrs of exposure. (scirp.org)
- Ambient testing, whereby the test organism is exposed to naturally occurring substances that contain toxicant mixtures in an organic or inorganic matrix, is more likely to meet these needs than are procedures that call for exposure of the test organisms to known concentrations of a single toxicant. (usgs.gov)
- Toxic Gas Exposure Screenining Tests. (inspectapedia.com)
- A three-brood toxicity test is conducted to help determine changes in survival and the number of neonates produced that result from exposure to the test material. (astm.org)
- 5.3 Results of three-brood toxicity tests with C. dubia might be used to predict chronic or partial chronic effects on species in field situations as a result of exposure under comparable conditions. (astm.org)
- 1.1 This guide describes procedures for obtaining data concerning the adverse effects of an effluent or a test material (added to dilution water, but not to food) on Ceriodaphnia dubia Richard 1894, during continuous exposure throughout a portion of the organism's life. (astm.org)
- The objective of an acute test is to determine the concentration of test material that produces lethality during a short-term exposure (48 or 96 hours). (wisc.edu)
- The objective of an acute WET test is to determine the concentration of effluent that causes 50% lethality (LC50) during a short-term exposure under controlled conditions. (wisc.edu)
- Standardised protocols for sediment testing, for example adapted spiking protocols and the use of passive sampling techniques to quantify exposure concentrations and account for bioavailability, could potentially help in the improved design, conduct and interpretation of sediment toxicity testing with these substances. (cefic-lri.org)
- Described is the cell culture and exposure method of an in vitro bronchial model for realistic, repeated inhalation exposure to particles for toxicity testing. (jove.com)
- For toxicity testing of airborne particles, air-liquid interface (ALI) exposure systems have been developed for in vitro tests in order to mimic realistic exposure conditions. (jove.com)
- In addition, this bronchial model is suitable for testing the effects of repeated exposures to low, realistic concentrations of airborne particles using an ALI exposure system. (jove.com)
- Taken together, this bronchial model, in combination with the continuous flow exposure system, is able to mimic realistic, repeated inhalation exposure conditions that can be used for toxicity testing. (jove.com)
- Validation of the dynamic direct exposure method for toxicity testing " by Lucky Joeng, Amanda Hayes et al. (edu.au)
- The results suggest that the dynamic direct exposure method has the potential to be implemented for both laboratory- and field-based in vitro toxicity studies of diesel exhaust emissions. (edu.au)
- Therefore, apart from ethynylestradiol all compounds were tested at dosages much higher than any likely exposure to be expected in humans. (openrepository.com)
Toxic13
- The toxic gas yields were also used to calculate a toxicity index (TI) parameter to assess the potential gas toxicity of belt materials during a fire. (cdc.gov)
- Furthermore, the TI and the mass loss burning rate values were used to calculate a toxicity hazard (TH) parameter to estimate the toxic gas hazard produced by a burning belt in a ventilated system. (cdc.gov)
- Testing for presence of toxic compounds is an important step during the development of new products such as drugs, cosmetics, and food additives, which can save both time and developmental costs as well as reduce the probability of failure during later stages. (medgadget.com)
- In vitro toxicity testing is a procedure that helps examine the presence of these toxic compounds over an isolated part of the organism. (medgadget.com)
- Toxicity testing is one type of biological monitoring that can be used to identify possible effects of toxic contaminants. (usgs.gov)
- Indoor air quality testing for toxic gases - level of toxicity of gases. (inspectapedia.com)
- Mmechanical systems such as heating system-produced carbon monoxide or flue gases, fire damage, or contamination from nearby industrial, beauty parlor, dry cleaning, or other activities which often produce noxious or toxic odors and gases are also tested. (inspectapedia.com)
- To test their system the researchers added toxic arsenic and cadmium compounds to the cells and then looked for human growth hormone in the culture media. (bio-medicine.org)
- To determine the potential risks involved, screening tests are needed to monitor wastewater for potential toxic contaminants. (scielo.org.za)
- Toxicity of sediment extracts and sediment was predicted using toxic unit (TU) approach and persistence, bioaccumulation and toxicity (PBT) ranking. (chemaxon.com)
- Predicted toxicity of sediment extracts (TUext) was similar to the results obtained by ZET and associated histopathology with Rugvica sediment being the most toxic, followed by Jesenice, Lukavec and Galdovo. (chemaxon.com)
- chemical, biological, physical, radiation and behavioural toxicity: Disease-causing microorganisms and parasites are toxic in a broad sense but are generally called pathogens rather than toxicants. (wikipedia.org)
- Because individuals typically have different levels of response to the same dose of a toxic substance, a population-level measure of toxicity is often used which relates the probabilities of an outcome for a given individual in a population. (wikipedia.org)
Long-term toxicity2
- Pesticide Action Network (PAN) Europe previously asked the German regulatory agencies to release the full range of long-term toxicity studies on glyphosate. (infowars.com)
- McKim, J.M. (1977) Evaluation of Tests with Early Life Stages of Fish for Predicting Long-Term Toxicity. (scirp.org)
Nanomaterial toxicity4
- Ultimate goals of this center are to eliminate the need for use of animals in the evaluation of chemical and nanomaterial toxicity and to help create a road map to responsible nanomanufacturing," says Rogers. (uml.edu)
- Currently, small animal models are the gold standard for nanomaterial toxicity testing. (nanowerk.com)
- This is creating a growing deficit in our understanding of nanomaterial toxicity, which fuels public apprehension towards nanotechnology. (nanowerk.com)
- Dr. André Nel and his coworkers at the California NanoSystems Institute (CNSI) and the University of California Los Angeles (UCLA) are taking a fundamentally different approach to nanomaterial toxicity testing. (nanowerk.com)
Compounds8
- Early toxicity testing is used during clinical trials, where the toxicity of the compounds present in the test product is evaluated. (medgadget.com)
- Usually, the tests are conducted for single chemical compounds. (enviweb.cz)
- Therefore, prediction of potential toxicities of candidate compounds is of great importance for successful drug development. (miltenyibiotec.com)
- Get high-throughput multiplexed data that gives you mechanistic insight into the toxicity of your compounds. (miltenyibiotec.com)
- Although the general toxicity of these compounds is well known because they are routinely used in cosmetic and food industry, their specific toxicity associated with inhalation is poorly studied. (proanima.fr)
- The toxicity of the model compounds was determined by using the Hydractinia echinata (Hydrozoa) test system. (ad-astra.ro)
- Compounds tested were the contraceptive Ethynylestradiol, the phytoestrogen Coumestrol, the surfactant 4-Tert-octylphenol, the plastic monomer Bisphenol A, the fungicide Vinclozolin, and the plasticizer Butylbenzylphthalate. (openrepository.com)
- Endocrine properties of xenobiotic compounds, assessed at the hormone receptor level, should be combined with in vivo data on their reproductive and general toxicity for proper risk evaluation and risk management of these compounds. (openrepository.com)
Laboratory17
- In addition to the tests listed above, laboratory studies for altered mental status may include serum osmolality, alcohol, and ketones. (medscape.com)
- The big picture here is to be able to use laboratory-based high throughput screening methods to predict material and chemical toxicity," says Prof. Eugene Rogers, chair of the Department of Clinical Laboratories and Nutritional Sciences. (uml.edu)
- We've developed a laboratory method that provides quick and accurate results for use by nanomaterial manufacturers that may reduce the need for animal testing," says Rogers. (uml.edu)
- The EPA has recognized that the data produced by our laboratory is valuable and useful in their CompTox program efforts and will be used to develop predictive toxicity approaches. (uml.edu)
- Assessing the risk of pollutants to animal organisms is typically based on laboratory tests. (enviweb.cz)
- In reality, conditions in nature vary widely, leading to inconsistencies between laboratory tests and how organisms are affected by pollutants in the natural environment. (enviweb.cz)
- Standard laboratory testing would detect no harm, but there could be ecological disruption in fields because of the effects on reproduction. (bio-medicine.org)
- Current tests for liver toxicity require multiple steps, such as freezing and grinding tissue in a laboratory, which usually take days and require the use of laboratory equipment. (straitstimes.com)
- A new Good Laboratory Practice compliant rat subcutaneous repeat dose toxicity study to evaluate a higher clinical dose and modified posology (once every 2 weeks for 13 weeks) showed no signs of toxicity. (medworm.com)
- Laboratory testing is used to assess the nutritional status (deficiency, sufficiency, and toxicity) of particular vitamins, including status in response to therapeutic supplementation. (arupconsult.com)
- When should laboratory testing for vitamins be performed rather than, or in addition to, supplementation? (arupconsult.com)
- Refer to your laboratory for specimen type, storage, and transport instructions when ordering simultaneous vitamin tests. (arupconsult.com)
- What effect does biotin (vitamin B7) have on other laboratory tests? (arupconsult.com)
- This book focuses on efficacy, toxicity, drug interactions, and abnormal clinical laboratory tests resulting from the use of herbal remedies. (ovid.com)
- Reliance on laboratory animals also incurs marked ― and in some cases, prohibitive ― logistical challenges, within high-throughput chemical testing programmes, such as those currently underway within Europe and the US. (all-creatures.org)
- To promote the microfluidic technology moving from the laboratory to the clinic, we developed a microfluidic-based perivascular tumor model that makes it possible to assess drug sensitivity in 3D cultured tumor spheroids and toxicity in endothelium in parallel. (rsc.org)
- EA is also an approved laboratory for Dredged Material Toxicity Testing for USACE New England District. (eaest.com)
Genotoxicity4
- Abstract Currently, toxicological testing of food contact materials (FCMs) is focused on single substances and their genotoxicity. (bionity.com)
- Raw wastewater and treated sewage effluents were screened for cytotoxicity using lactate dehydrogenase (LDH) release from cells as biomarker, for neurotoxicity using acetylcholinesterase (AChE) inhibition and for genotoxicity using the Save Our Soul (SOS) test. (scielo.org.za)
- Raw wastewater from all sewage treatment plants tested positive for genotoxicity. (scielo.org.za)
- In vitro methods for mechanistic genotoxicity screening could offer major advantages in identifying the toxicity profile of a compound. (miltenyibiotec.com)
Assay8
- Patients can be tested for DPD deficiency using a functional enzymatic assay that Mayo Clinic researchers have also developed. (medscape.com)
- There also wouldn't be enough time or laboratories in the United States to begin to test all prospective 5-FU/capecitabine patients using their functional assay, he added. (medscape.com)
- Toxicity assay carried out by using brine shrimps. (hindawi.com)
- However, this assay does not recapitulate the intricacies of hematopoiesis in vivo , nor does it replace in vivo testing in mice. (taconic.com)
- Thus, the in vitro test may not correlate with your animal test, meaning that you cannot make appropriate inferences from the cell death assay. (nanowerk.com)
- The Aflatoxin B1 Food ELISA Kit is a quantitative test based on the principle of the enzyme linked immunosorbent assay. (rapidtest.com)
- In this webinar, Miltenyi Biotec and Toxys introduce the ToxTracker® assay, an early-stage, high-content, mechanism-based in vitro assay which can speed up drug development and reduce animal testing requirements. (miltenyibiotec.com)
- Glyphosate testing is conducted via the ELISA (enzyme linked immunosorbent assay) method, which utilizes an antibody specific for glyphosate. (enviroscienceinc.com)
Vivo9
- The early toxicity testing market experienced moderate growth in the recent years due to the replacement of in vivo models by in vitro models and technological advancement in in vitro and in silico techniques. (medgadget.com)
- There is increasing recognition that new approaches are needed to bridge the gap between preclinical in vitro and in vivo testing to reduce costly late-stage attrition of new drugs. (nc3rs.org.uk)
- You need to align what you test at a cellular level with what you want to know at the in vivo ' says Nel. (nanowerk.com)
- Stem cell derived in vivo-like human cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging. (sigmaaldrich.com)
- Beating in vivo-like human cardiac bodies (CBs) were used in a microfluidic device for testing cardiotoxicity. (sigmaaldrich.com)
- in vivo studies require a large number of expensive, time consuming and in some cases non humane tests in animal species. (edu.au)
- Compared to in vivo studies, in vitro toxicity testing is believed to be more useful at an early stage of drug development due to short turnaround times and relatively low cost. (miltenyibiotec.com)
- Animal testing, also known as animal experimentation, animal research and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study. (wikipedia.org)
- The terms animal testing, animal experimentation, animal research, in vivo testing, and vivisection have similar denotations but different connotations. (wikipedia.org)
Evaluation14
- In the first session, speakers provided an overview of toxicity testing strategies to advance the use of 21st-century science in chemical safety evaluation. (nih.gov)
- Zbinden G, Flury-Roversi M (1981) Significance of the LD 50 -Test for the toxicological evaluation of chemical substances. (springer.com)
- Evaluation of test methods that reliably identify ocular corrosives and irritants while replacing, reducing, and refining animal use is a high priority for NICEATM and ICCVAM. (nih.gov)
- The 2010 report on the ICCVAM evaluation of these test methods includes recommendations for future studies that could potentially improve these methods. (nih.gov)
- The memorandum covers three critical areas of test method evaluation: validation studies, independent scientific peer review meetings and reports, and development of test method recommendations for regulatory consideration," said Marilyn Wind, Ph.D., chair of the Interagency Coordinating Committee on the Validation of Alternative Methods and a scientist at the Consumer Product Safety Commission (CPSC). (opposingviews.com)
- Spheroids are one example of these, and are typically used to assess the chemical toxicity and evaluation of environmental samples in biological and ecotoxological studies. (eurekalert.org)
- They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical product notification, chemical registration and in chemical evaluation. (oecd-ilibrary.org)
- This partnership builds upon FDA's commitment to developing new methods to evaluate the toxicity of the substances that we regulate," said Janet Woodcock, M.D., director of the FDA Center for Drug Evaluation and Research. (genome.gov)
- A TRE is a systematic evaluation of the wastewater treatment plant or industrial facility effluent to determine sources of toxicity and ultimately uncover how to control toxicity. (wisc.edu)
- TREs may include chemical screening, process reviews, evaluation of treatment plant performance and toxicity identification evaluation (TIE). (wisc.edu)
- Dr. Hajjar will be speaking about innovative approaches to preventing cardiac toxicity in new drugs at the World Pharmaceutical Congress in Philadelphia on May 12, 2008 when he gives a presentation entitled: "Evaluation of Cardiotoxicity of Novel Molecular Therapies. (bio-medicine.org)
- Multicenter Prospective Evaluation of a Predictive Test of Late Toxicities After Radiotherapy by the Rate of Radiation Induced CD8 T-Lymphocyte Apoptosis: Application to Breast and Prostate Cancers. (knowcancer.com)
- Toxicity evaluation of the sediment extracts from four locations (Jesenice, Rugvica, Galdovo and Lukavec) using zebrafish embryotoxicity test (ZET) accompanied with semi-quantitative histopathological analyses exhibited correlation with cumulative number and concentrations of OCs at the investigated sites (10.05, 15.22, 1.25, and 9.13 μg/g respectively). (chemaxon.com)
- These data suggest that endocrine disruptors are likely to be effective in existing reproductive toxicity test systems used for human risk evaluation. (openrepository.com)
Approaches11
- The NIEHS Superfund Research Program (SRP) hosted a webinar series highlighting research that may be useful as new approaches and methodologies for toxicity testing. (nih.gov)
- Our collaboration will help to identify and embrace scientifically sound and robust new testing approaches, ensuring that safety assessments are never compromised, while at the same time reduce the need for animal testing. (opposingviews.com)
- 2018. Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report. (nih.gov)
- More than 40 scientists from international regulatory agencies, academia, nongovernmental organizations, and industry attended a workshop organized to develop recommendations for advancing new approaches for acute inhalation toxicity testing. (nih.gov)
- These inform both essential testing needs to be addressed by alternative approaches and opportunities for existing information to enable waivers of required testing. (nih.gov)
- Additivity approaches may be useful for estimating toxicity of mixtures. (nih.gov)
- Originally, there was not enough consideration of what approaches were chosen to assess toxicity in vitro . (nanowerk.com)
- Toxicity-test approaches vary in their capacity to meet the needs of large-scale assessments of existing water quality. (usgs.gov)
- One of the most informative approaches to toxicity testing is to combine biochemical tests with other test methods in a 'battery of tests' that is diversified enough to characterize different types of toxicants and different trophic levels. (usgs.gov)
- The result is a collection that reveals the properties, strengths, and weaknesses that exist in the various approaches to bench test problems. (lovereading.co.uk)
- Here we discuss how new in vitro approaches in both ADME and toxicity testing can be leveraged to increase efficiencies within the drug discovery pipeline to help companies take new drugs to the market in a faster manner, and potentially reducing costs. (ddw-online.com)
Organisms8
- Based on experimentation designed to monitor responses of organisms to environmental stresses, toxicity testing may have diverse purposes in water-quality assessments. (usgs.gov)
- In addition to conducting an acute test with unfed C. dubia , it might also be desirable to conduct an acute test in which the organisms are fed the same as in the three-brood test, to see if the presence of that concentration of that food affects the results of the acute test and the acute chronic ratio (see 10.4.1 ). (astm.org)
- 5.7 Results of three-brood toxicity tests with C. dubia can vary with temperature, quality and quantity of food, quality of the dilution water, condition of the test organisms, and other factors. (astm.org)
- In whole effluent toxicity (WET) tests, organisms are exposed to various effluent concentrations for a specific time period in order to estimate the effluent's toxicity. (wisc.edu)
- The most commonly used organisms in WET tests, and the ones required by the WDNR, are the fathead minnow (Pimephales promelas) and an invertebrate (Ceriodaphnia dubia). (wisc.edu)
- During a chronic test, the organisms are continuously exposed to the test material at various concentrations. (wisc.edu)
- Tests are designed to encompass the entire life cycle or most sensitive life stage of the organisms. (wisc.edu)
- The IC25 value is a statistical calculation of the effluent concentration which causes a 25% reduction in growth or reproduction of test organisms. (wisc.edu)
Substances10
- ICCVAM concluded that the performance of the other four test methods must be improved before they can be used in regulatory safety testing to identify substances that may cause nonsevere eye injuries or that do not require eye irritation hazard labeling. (nih.gov)
- Indoor Air Investigation Tests for substances in gas form. (inspectapedia.com)
- Gas detector tubes , used with a special calibrated Sensidyn™ or Drager™ pump [3] provide specific, accurate tests for the presence of target substances at the moment of testing. (inspectapedia.com)
- Ten of these gases and substances produced by burning common materials found in buildings are addressed by the Draeger Simultaneous Test Sets I and II. (inspectapedia.com)
- The Draeger Simultaneous Test Sets screen for these specific substances in the immediate vicinity. (inspectapedia.com)
- It is known that UVCB substances cannot be sufficiently identified by their chemical composition, which creates the complications for testing using standard guideline methodologies. (cefic-lri.org)
- This book works with four bench test problems that were taken from real bioassay data for hazardous substances currently under study by the United States Environmental Protection Agency (EPA). (lovereading.co.uk)
- With the help of those systems Reif tries to identify hepatotoxic substances without animal testing. (ifado.de)
- In addition, water solubility limits (in sediment pore-water) for hydrophobic substances might be reached at relatively low test concentrations, thereby hampering the determination of reliable concentration response curves. (cefic-lri.org)
- Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. (wikipedia.org)
Clinical15
- In fact, in 2018, the French Group on Clinical Pharmacology in Oncology recommended that physicians screen all patients for potential DPD deficiency to "red flag" those at potential risk for severe 5-FU toxicity. (medscape.com)
- Liver toxicity is a principal safety concern during drug discovery and development, with the potential to terminate expensive clinical trials already underway. (businesswire.com)
- These include tests on clinical drugs, foods, and environmental pollutants. (harvard.edu)
- It is ready to be used in the clinical setting now, and, as both CD4 and CD8 showed similar results, we need test for CD8 only. (eurekalert.org)
- Through CRACK IT Solutions, ZeClinics are collaborated with two companies, Noldus and Pivot Park Screening Centre and were awarded Solutions funding to validate the platform against compound sets with known preclinical and clinical toxicity data and are seeking to automate the complete procedure. (nc3rs.org.uk)
- With the Solutions funding awarded the consortium validated the ZeGlobalTox platform against compound sets with known preclinical and clinical toxicity data. (nc3rs.org.uk)
- Previous non ‐clinical safety testing, including rat repeat dose toxicity in adult and juvenile animals, rat reproductive toxicity and rabbit local tolerance studies showed no safety findings of concern. (medworm.com)
- The failure of safety prediction was pointed to species specificity issues, lack of mechanistic toxicity data and inadequate clinical trials. (rutgers.edu)
- Greater commitment to their development and implementation is necessary, however, to efficiently meet the needs of high-throughput chemical testing programmes, important emerging testing needs, and the ongoing development of human clinical interventions. (all-creatures.org)
- If ARUP Consult does not answer your test selection and interpretation questions, or if you'd like to suggest ways to improve content or usability, please leave a message for the ARUP clinical content team. (arupconsult.com)
- A drug sensitivity test prior to clinical treatment is necessary for individualized cancer therapy. (rsc.org)
- This study demonstrated that the microfluidic model might be a useful platform for individual drug tests prior to clinical treatment. (rsc.org)
- Understanding the ADME (absorption, distribution, metabolism and excretion) and toxicity of new drugs are key parts of the compound testing process, during preclinical and clinical trials, providing insights into the disposition of a pharmaceutical compound, including its safety and efficacy. (ddw-online.com)
- In recent years, advances in the understanding of hepatocyte function, cell signalling, liver toxicity mechanisms and cell culture techniques have led to numerous advances in compound testing for both preclinical and clinical trial purposes. (ddw-online.com)
- DTI redefines drug toxicity, identifies hepatotoxic drugs, gives mechanistic insights, predicts clinical outcomes and has potential as a screening tool. (wikipedia.org)
Whole effluent toxicity1
- Whole effluent toxicity (WET) tests are a critical component of Wisconsin Pollutant Discharge Elimination System (WPDES) permits. (wisc.edu)
Sediment4
- Sediment tests have had limited application, but they are useful because most toxicants tend to accumulate in sediments and many test species either inhabit the sediments or are in frequent contact with them. (usgs.gov)
- in pore water in replicate 96-h and 10-d sediment toxicity tests. (usgs.gov)
- Testing at elevated concentrations may introduce neat substance into the sediment exposures that may confound interpretation of test results due to physical effects. (cefic-lri.org)
- Results suggest that comprehensive in silico sediment toxicity predictions advocate providing equal attention to organic contaminants with either very low or very high log K. (chemaxon.com)
Zebrafish3
- To assess the effects of acrylamide to freshwater fish, Zebrafish (Danio rerio) embryos were exposed to serial concentrations of acrylamide (0, 100, 300, and 500 mg/L) to investigate the acute toxicity effects on teleost embryogenesis. (scirp.org)
- The lower test, 100 mg/L, produced a significant number of developmental anomalies to the Zebrafish that included dorsal tail flexure, severe pericardial edema, facial and cranial defects and decreased heartrate (40 bpm). (scirp.org)
- These results indicate that acrylamide is teratogenic and provide support for sub-lethal toxicity testing using Zebrafish embryos. (scirp.org)
Findings5
- Describe pulmonary function test findings associated with asbestosis. (cdc.gov)
- It is nonspecific, and positive test findings only indicate presence of an amphetamine drug class. (medscape.com)
- Confirmation by means of gas chromatography and/or mass spectrometry is strongly recommended when test findings are positive for amphetamines. (medscape.com)
- An important aspect of the interpretation of toxicity test findings is the quantity of the chemical present in terms of tissue concentration or blood level. (forensicpanel.com)
- However, later toxicity tests posed different findings. (enviroscienceinc.com)
Predictive2
- He continued: "To our knowledge, this is the first rapid predictive test based on lymphocyte apoptosis confirmed prospectively in a large number of patients. (eurekalert.org)
- They have moved from predominantly observational science at the level of disease-specific testing to more predictive models focused on target-specific, mechanism-based biological observations. (miltenyibiotec.com)
Chronic toxicity tests2
Developmental4
- When it comes to testing their potential to cause reproductive and developmental harm, oligonucleotide-based therapeutics present unique challenges. (medindia.net)
- Dr. John M. DeSesso recently authored an opinion that explores the future of developmental toxicity testing and how this will impact safety testing. (exponent.com)
- Exponent toxicologists have extensive experience in planning, conducting and coordinating regulatory guideline-based toxicity studies and investigative mechanistic studies to address potential developmental and reproductive issues. (exponent.com)
- This Test Guideline describes a method to estimate the developmental toxicity of a test chemical to the dung dwelling life stages of dung-dependent dipteran species. (oecd.org)
Acute inhalation toxicity1
- Familiarity with non-animal methods for acute inhalation toxicity testing. (norecopa.no)
Toxicological2
- Although hair and saliva analysis may be obtained, most toxicological monitoring or testing is performed with urine and blood samples. (medscape.com)
- By using an in vitro HT screening approach, comprehensive toxicological testing of a nanomaterial can be performed in a matter of days. (nanowerk.com)
Refine1
- Animal welfare will also be improved by the national and international acceptance of alternative test methods that reduce, refine, and replace the use of animals. (opposingviews.com)
Workup1
- What tests are performed in the workup of vitamin toxicity? (medscape.com)
20161
- Early Toxicity Testing Market is anticipated to reach $1,012 million by 2022, registering a CAGR of 7.3% during the forecast period, 2016 to 2022, according to a new report published by Allied Market Research. (medgadget.com)
Methods17
- A total of 9 plant extracts were tested, using two different kinds of extracting methods to evaluate the antioxidant and antimicrobial activities from Pilea microphylla (Urticaceae family) and including toxicity test. (hindawi.com)
- The dynamism of the company can be seen from their constant challenging of the status quo to see if new and improved methods of water testing are possible. (environmental-expert.com)
- The endorsement of several alternative testing methods by Federal agencies has provided regulated industries with important new tools for assessing potential eye injury hazards. (nih.gov)
- The new test methods were the topic of a 2011 workshop organized by NICEATM and ICCVAM. (nih.gov)
- In 2010, ICCVAM evaluated and developed recommendations for five in vitro test methods used to identify ocular irritants. (nih.gov)
- The agreement between the United States, Canada, Japan and the European Union will yield globally coordinated scientific recommendations on alternative toxicity testing methods that should speed their adoption in each of these countries, thus reducing the number of animals needed for product safety testing. (opposingviews.com)
- The agreement promotes enhanced international cooperation and coordination on the scientific validation of non- and reduced-animal toxicity testing methods. (opposingviews.com)
- If the toxicity testing methods are shown to be reproducible based on strong scientific information, and able to accurately identify product related health hazards, the tests are more readily accepted by regulatory agencies. (opposingviews.com)
- It will speed the adoption of new test methods based on advances in science and technology that will provide more accurate predictions of safety or hazard. (opposingviews.com)
- ICCVAM is working to promote the development and validation of alternative test methods. (opposingviews.com)
- Alternative test methods are those that accomplish one or more of the 3Rs - reducing the number of animals used in testing, or refining procedures so animals experience less pain and distress, or replacing animals with non-animal systems. (opposingviews.com)
- The authors of the article, Jonathan G. Lundgren and Jian J. Duan of the USDA Agricultural Research Service, argue that pesticides and insect-resistant crops based on RNA interference, now in exploratory development, may have to be tested under elaborate procedures that assess effects on animals' whole life cycles, rather than by methods that look for short-term toxicity. (bio-medicine.org)
- A wide variety of toxicity-test methods have been developed to fulfill the needs of diverse applications. (usgs.gov)
- The methods differ primarily in the selections made relative to four characteristics: (1) test species, (2) endpoint (acute or chronic), (3) test-enclosure type, and (4) test substance (toxicant) that functions as the environmental stress. (usgs.gov)
- Biochemical testing methods, which have been developing rapidly in recent years, are likely to be among the most useful procedures for large-scale water-quality assessments. (usgs.gov)
- CAMBRIDGE, Mass., May 8 /PRNewswire/ -- In response to ever increasing cardiac toxicity found in market drugs, Gwathmey Preclinical Testing Services, Inc. today announced the launch of new Cardionomics(TM) services and the formation of its Cardionomics(TM) Advisory Board to provide new methods and technologies to improve cardiac safety of drug candidates. (bio-medicine.org)
- The objectives of this study were to evaluate the sensitivity of two bacterial tests commonly used in metal toxicity screening - the Vibrio fischeri bioluminescence inhibition test and the Pseudomonas putida growth inhibition test - in comparison to the standard acute Daphnia magna test, and to estimate applicability of the selected methods to the toxicity testing of environmental samples. (semanticscholar.org)
Determine the toxicity2
- An array of tests used to determine the toxicity of a substance to living systems. (harvard.edu)
- The aim of this study was to validate and use screening tests to determine the toxicity of raw wastewater and treated sewage effluents from 3 sewage treatment plants in the Western Cape, South Africa. (scielo.org.za)
Suitable for toxicity1
- However, primary cells differ from batch to batch, are more difficult to maintain, and are more expensive compared to cell lines, which makes them less suitable for toxicity testing and screening. (jove.com)
Concentrations6
- Acute toxicity is measured by exposing Brachionus newly hatched from cysts to a series of toxicant concentrations under controlled conditions. (astm.org)
- If the toxicity of the chemical is unknown, five nominal test concentrations should be conducted. (oecd.org)
- 5.5.1 A 48 or 96-h EC50 or LC50 can sometimes be obtained from a three-brood toxicity test with a known test material, but often all the concentrations in the test will be below the EC50 or LC50. (astm.org)
- In addition, it is usually desirable to know the EC50 or LC50 before beginning the three-brood test, as a means to determine the concentrations for use in the chronic test (see 10.4.1 ). (astm.org)
- A combination of low concentrations of these drugs presented a good curative effect on tumor cells and low toxicity to the HUVEC layer. (rsc.org)
- Further, such tests may not be considered appropriate given the estimated environmental concentrations following emissions from typical use patterns. (cefic-lri.org)
Rats1
- Hunter WJ, Lingk W, Recht R (1979) Intercomparison study on the determination of single administration toxicity in rats. (springer.com)
Endpoint2
- To this end, the standard safety test design for this type of endpoint was developed in the mid-1960's and has changed little in the ensuing half-century. (exponent.com)
- 0.826, respectively between the measured and model predicted endpoint toxicity values in the test data. (rsc.org)
Predict2
- It can predict significantly the differences in radiation-induced late toxicity between patients, and could be used as a rapid screen for genetically hypersensitive patients. (eurekalert.org)
- Animal rights organizations-such as PETA and BUAV-question the need for and legitimacy of animal testing, arguing that it is cruel and poorly regulated, that medical progress is actually held back by misleading animal models that cannot reliably predict effects in humans, that some of the tests are outdated, that the costs outweigh the benefits, or that animals have the intrinsic right not to be used or harmed in experimentation. (wikipedia.org)
Effluents1
- With appropriate modifications these procedures can be used to conduct tests on temperature, dissolved oxygen, pH, and on such materials as aqueous effluents (see also Guide E1192 ), leachates, oils, particulate matter, sediments (see also Guide E1383 ), and surface waters. (astm.org)
Liver toxicity5
- SINGAPORE - Scientists here have developed a way of testing for liver toxicity in just an hour, shortening the wait for results that usually take days. (straitstimes.com)
- When rolled out clinically, this could benefit cancer patients by quickly detecting liver toxicity, a common side effect of chemotherapy. (straitstimes.com)
- They use biomarkers (genes) for liver toxicity. (straitstimes.com)
- The scientists have successfully used both these chips to detect liver toxicity. (straitstimes.com)
- Our new method significantly reduces time, manpower and costs and yet has the same accurate results as the gold standards of current liver toxicity tests. (straitstimes.com)
Biological toxicity1
- The biological toxicity of pathogens can be difficult to measure because the "threshold dose" may be a single organism. (wikipedia.org)
Silico1
- In silico method and In vitro models has been observed as a recent trends in the In vitro toxicity testing market which are expected to witness substantial growth in the near future, due to their rapid adoption and technological advancement. (sbwire.com)
Chemical8
- A method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD 50 , is described. (springer.com)
- New consensus guidelines for toxicity testing that take into consideration the combined chemical and biological characteristics of these novel biopharmaceuticals are presented in Nucleic Acid Therapeutics , a peer-reviewed journal from Mary Ann Liebert, Inc. publishers. (medindia.net)
- The oxygen content of water affected chemical toxicity in 7 studies. (enviweb.cz)
- Using Electron Paramagnetic Resonance (EPR) oximetry, scientists assessed the gradient of oxygen concentration within spheroids, 3D cell cultures typically used for testing the chemical toxicity within liver and tumour models. (eurekalert.org)
- The test chemical is mixed with bovine faeces, to which either 10 eggs of Scathophaga stercoraria or 10 larvae of Musca autumnalis are added. (oecd.org)
- Toxicity-test results are most effective when used as a complement to chemical analyses, hydrologic measurements, and other biological monitoring. (usgs.gov)
- However, meaningful interpretation of ambient test results depends on the existence of accompanying chemical analysis of the ambient media. (usgs.gov)
- Introduced for use in effluent and ambient water evaluations, Ceriodaphnia have also been a valuable addition to single chemical test procedures. (astm.org)
Drug Toxicity2
- Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. (medindia.net)
- Considering the limitations of this dose-response concept, a novel Drug Toxicity Index (DTI) has been proposed recently. (wikipedia.org)