Discrete concentrations of energy, apparently massless elementary particles, that move at the speed of light. They are the unit or quantum of electromagnetic radiation. Photons are emitted when electrons move from one energy state to another. (From Hawley's Condensed Chemical Dictionary, 11th ed)
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Imaging methods that result in sharp images of objects located on a chosen plane and blurred images located above or below the plane.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
A gamma-emitting RADIONUCLIDE IMAGING agent used in the evaluation of regional cerebral blood flow and in non-invasive dynamic biodistribution studies and MYOCARDIAL PERFUSION IMAGING. It has also been used to label leukocytes in the investigation of INFLAMMATORY BOWEL DISEASES.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Compounds that contain the radical R2C=N.OH derived from condensation of ALDEHYDES or KETONES with HYDROXYLAMINE. Members of this group are CHOLINESTERASE REACTIVATORS.
An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.
An amphetamine analog that is rapidly taken up by the lungs and from there redistributed primarily to the brain and liver. It is used in brain radionuclide scanning with I-123.
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Projection of near-IR light (INFRARED RAYS), in the 700-1000 nm region, across an object in parallel beams to an array of sensitive photodetectors. This is repeated at various angles and a mathematical reconstruction provides three dimensional MEDICAL IMAGING of tissues. Based on the relative transparency of tissues to this spectra, it has been used to monitor local oxygenation, brain and joints.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.
Unstable isotopes of xenon that decay or disintegrate emitting radiation. Xe atoms with atomic weights 121-123, 125, 127, 133, 135, 137-145 are radioactive xenon isotopes.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.
The use of combination of imaging techniques or platforms (e.g., MRI SCAN and PET SCAN) encompassing aspects of anatomical, functional, or molecular imaging methods.
Computed tomography modalities which use a cone or pyramid-shaped beam of radiation.
A tomographic technique for obtaining 3-dimensional images with transmission electron microscopy.
N-methyl-8-azabicyclo[3.2.1]octanes best known for the ones found in PLANTS.
Self-generated faint acoustic signals from the inner ear (COCHLEA) without external stimulation. These faint signals can be recorded in the EAR CANAL and are indications of active OUTER AUDITORY HAIR CELLS. Spontaneous otoacoustic emissions are found in all classes of land vertebrates.
Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation.
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
Tomography using single-photon emitting RADIONUCLIDES to create images that are captured in times corresponding to various points in the cardiac cycle.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Tomography using x-ray transmission.
Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.
The hollow, muscular organ that maintains the circulation of the blood.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Emission or propagation of acoustic waves (SOUND), ELECTROMAGNETIC ENERGY waves (such as LIGHT; RADIO WAVES; GAMMA RAYS; or X-RAYS), or a stream of subatomic particles (such as ELECTRONS; NEUTRONS; PROTONS; or ALPHA PARTICLES).
One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
X-ray image-detecting devices that make a focused image of body structures lying in a predetermined plane from which more complex images are computed.
That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.
Gases, fumes, vapors, and odors escaping from the cylinders of a gasoline or diesel internal-combustion engine. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Random House Unabridged Dictionary, 2d ed)
Elements of limited time intervals, contributing to particular results or situations.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.
Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
Radioactive substances added in minute amounts to the reacting elements or compounds in a chemical process and traced through the process by appropriate detection methods, e.g., Geiger counter. Compounds containing tracers are often said to be tagged or labeled. (Hawley's Condensed Chemical Dictionary, 12th ed)
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
Electronic instruments that produce photographs or cathode-ray tube images of the gamma-ray emissions from organs containing radionuclide tracers.
The diversion of RADIATION (thermal, electromagnetic, or nuclear) from its original path as a result of interactions or collisions with atoms, molecules, or larger particles in the atmosphere or other media. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Photosensitive afferent neurons located in the peripheral retina, with their density increases radially away from the FOVEA CENTRALIS. Being much more sensitive to light than the RETINAL CONE CELLS, the rod cells are responsible for twilight vision (at scotopic intensities) as well as peripheral vision, but provide no color discrimination.
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; FLUORESCENCE IMAGING; and MICROSCOPY.
Measurement of the intensity and quality of fluorescence.
Methods of creating machines and devices.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.
In statistics, a technique for numerically approximating the solution of a mathematical problem by studying the distribution of some random variable, often generated by a computer. The name alludes to the randomness characteristic of the games of chance played at the gambling casinos in Monte Carlo. (From Random House Unabridged Dictionary, 2d ed, 1993)
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.
A serotonin antagonist with limited antihistaminic, anticholinergic, and immunosuppressive activity.
Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Unstable isotopes of nitrogen that decay or disintegrate emitting radiation. N atoms with atomic weights 12, 13, 16, 17, and 18 are radioactive nitrogen isotopes.
A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.
The flow of BLOOD through or around an organ or region of the body.
The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.
The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.
Disorders of the centrally located thalamus, which integrates a wide range of cortical and subcortical information. Manifestations include sensory loss, MOVEMENT DISORDERS; ATAXIA, pain syndromes, visual disorders, a variety of neuropsychological conditions, and COMA. Relatively common etiologies include CEREBROVASCULAR DISORDERS; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; BRAIN HYPOXIA; INTRACRANIAL HEMORRHAGES; and infectious processes.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Determination of the energy distribution of gamma rays emitted by nuclei. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Substances used to allow enhanced visualization of tissues.
The process in which light signals are transformed by the PHOTORECEPTOR CELLS into electrical signals which can then be transmitted to the brain.
A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
Microsurgical revascularization to improve intracranial circulation. It usually involves joining the extracranial circulation to the intracranial circulation but may include extracranial revascularization (e.g., subclavian-vertebral artery bypass, subclavian-external carotid artery bypass). It is performed by joining two arteries (direct anastomosis or use of graft) or by free autologous transplantation of highly vascularized tissue to the surface of the brain.
The circulation of blood through the CORONARY VESSELS of the HEART.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Deficient development or degeneration of a portion of the VERTEBRA, usually in the pars interarticularis (the bone bridge between the superior and inferior facet joints of the LUMBAR VERTEBRAE) leading to SPONDYLOLISTHESIS.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A representation, generally small in scale, to show the structure, construction, or appearance of something. (From Random House Unabridged Dictionary, 2d ed)
A purplish-red, light-sensitive pigment found in RETINAL ROD CELLS of most vertebrates. It is a complex consisting of a molecule of ROD OPSIN and a molecule of 11-cis retinal (RETINALDEHYDE). Rhodopsin exhibits peak absorption wavelength at about 500 nm.
The span of viability of a tissue or an organ.
Dominance of one cerebral hemisphere over the other in cerebral functions.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Individual components of atoms, usually subatomic; subnuclear particles are usually detected only when the atomic nucleus decays and then only transiently, as most of them are unstable, often yielding pure energy without substance, i.e., radiation.
Function of the human eye that is used in dim illumination (scotopic intensities) or at nighttime. Scotopic vision is performed by RETINAL ROD PHOTORECEPTORS with high sensitivity to light and peak absorption wavelength at 507 nm near the blue end of the spectrum.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in cardiovascular and cerebral circulation.
Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.
A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
The conversion of absorbed light energy into molecular signals.
The effect of GLOBAL WARMING and the resulting increase in world temperatures. The predicted health effects of such long-term climatic change include increased incidence of respiratory, water-borne, and vector-borne diseases.
Detection and counting of scintillations produced in a fluorescent material by ionizing radiation.
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Neoplasms of the bony part of the skull.
Computer-based representation of physical systems and phenomena such as chemical processes.
Niobium. A metal element atomic number 41, atomic weight 92.906, symbol Nb. (From Dorland, 28th ed)
A noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
Posterior portion of the CEREBRAL HEMISPHERES responsible for processing visual sensory information. It is located posterior to the parieto-occipital sulcus and extends to the preoccipital notch.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Fluorescence microscopy utilizing multiple low-energy photons to produce the excitation event of the fluorophore. Multiphoton microscopes have a simplified optical path in the emission side due to the lack of an emission pinhole, which is necessary with normal confocal microscopes. Ultimately this allows spatial isolation of the excitation event, enabling deeper imaging into optically thick tissue, while restricting photobleaching and phototoxicity to the area being imaged.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Behavior of LIGHT and its interactions with itself and materials.
Specialized cells in the invertebrates that detect and transduce light. They are predominantly rhabdomeric with an array of photosensitive microvilli. Illumination depolarizes invertebrate photoreceptors by stimulating Na+ influx across the plasma membrane.
The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.
Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
Techniques used for determining the values of photometric parameters of light resulting from LUMINESCENCE.
Emission of LIGHT when ELECTRONS return to the electronic ground state from an excited state and lose the energy as PHOTONS. It is sometimes called cool light in contrast to INCANDESCENCE. LUMINESCENT MEASUREMENTS take advantage of this type of light emitted from LUMINESCENT AGENTS.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
A non-inherited congenital condition with vascular and neurological abnormalities. It is characterized by facial vascular nevi (PORT-WINE STAIN), and capillary angiomatosis of intracranial membranes (MENINGES; CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.
Use of radiolabeled antibodies for diagnostic imaging of neoplasms. Antitumor antibodies are labeled with diverse radionuclides including iodine-131, iodine-123, indium-111, or technetium-99m and injected into the patient. Images are obtained by a scintillation camera.
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A specialized field of physics and engineering involved in studying the behavior and properties of light and the technology of analyzing, generating, transmitting, and manipulating ELECTROMAGNETIC RADIATION in the visible, infrared, and ultraviolet range.
Computer systems or networks designed to provide radiographic interpretive information.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints.
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A species of the true toads, Bufonidae, becoming fairly common in the southern United States and almost pantropical. The secretions from the skin glands of this species are very toxic to animals.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
A measure of the total greenhouse gas emissions produced by an individual, organization, event, or product. It is measured in units of equivalent kilograms of CARBON DIOXIDE generated in a given time frame.
Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.
Devices which accelerate electrically charged atomic or subatomic particles, such as electrons, protons or ions, to high velocities so they have high kinetic energy.
Narrowing or constriction of a coronary artery.
The creation of a visual display of the inside of the entire body of a human or animal for the purposes of diagnostic evaluation. This is most commonly achieved by using MAGNETIC RESONANCE IMAGING; or POSITRON EMISSION TOMOGRAPHY.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The veins and arteries of the HEART.
Improvement in the quality of an x-ray image by use of an intensifying screen, tube, or filter and by optimum exposure techniques. Digital processing methods are often employed.
Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement. Hypotonia and pendular reflexes are often associated. Conditions which feature recurrent or persistent episodes of chorea as a primary manifestation of disease are referred to as CHOREATIC DISORDERS. Chorea is also a frequent manifestation of BASAL GANGLIA DISEASES.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.
Materials that have a limited and usually variable electrical conductivity. They are particularly useful for the production of solid-state electronic devices.
Pathological conditions of intracranial ARTERIES supplying the CEREBRUM. These diseases often are due to abnormalities or pathological processes in the ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; and POSTERIOR CEREBRAL ARTERY.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Tellurium. An element that is a member of the chalcogen family. It has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.
Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)
The spectrometric analysis of fluorescent X-RAYS, i.e. X-rays emitted after bombarding matter with high energy particles such as PROTONS; ELECTRONS; or higher energy X-rays. Identification of ELEMENTS by this technique is based on the specific type of X-rays that are emitted which are characteristic of the specific elements in the material being analyzed. The characteristic X-rays are distinguished and/or quantified by either wavelength dispersive or energy dispersive methods.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
The rate dynamics in chemical or physical systems.
LIGHT, it's processes and properties, and the characteristics of materials interacting with it.
Three-dimensional computed tomographic imaging with the added dimension of time, to follow motion during imaging.
Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Pathologic deposition of calcium salts in tissues.
Upper central part of the cerebral hemisphere. It is located posterior to central sulcus, anterior to the OCCIPITAL LOBE, and superior to the TEMPORAL LOBES.
Unstable isotopes of copper that decay or disintegrate emitting radiation. Cu atoms with atomic weights 58-62, 64, and 66-68 are radioactive copper isotopes.
Inorganic compounds that contain cadmium as an integral part of the molecule.
The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.
The adjustment of the eye to variations in the intensity of light. Light adaptation is the adjustment of the eye when the light threshold is increased; DARK ADAPTATION when the light is greatly reduced. (From Cline et al., Dictionary of Visual Science, 4th ed)

Cardiac sympathetic activity estimated by 123I-MIBG myocardial imaging in patients with dilated cardiomyopathy after beta-blocker or angiotensin-converting enzyme inhibitor therapy. (1/4352)

Impaired cardiac sympathetic activity can be evaluated by 123I-metaiodobenzylguanidine (MIBG) imaging. METHODS: We studied the significance of MIBG imaging for 24 patients (age 58+/-12 y) with dilated cardiomyopathy (DCM). We compared 12 patients (group A) treated with metoprolol (dose from 30-60 mg/d) with 12 patients treated with angiotensin-converting enzyme (ACE) inhibitors. Patients were studied before treatment, after 5 mo of treatment (only in group A) and after 1 y of treatment. Cardiac MIBG uptake was assessed as the heart-to-mediastinum activity ratio (H/M) and total defect score (TDS) from anterior planar and SPECT MIBG images, which were acquired in 4 h after tracer injection. New York Heart Association (NYHA) class and left ventricular ejection fraction (LVEF) calculated by echocardiography were also assessed. RESULTS: TDS decreased in both groups (in group A, from 30+/-7 through 23+/-9 to 18+/-10; P < 0.01, in group B, from 30+/-6 to 24+/-8; P < 0.01) and H/M was increased in both groups (in group A, from 1.87+/-0.31 through 2.03+/-0.28 to 2.14+/-0.29; P < 0.01, in group B, from 1.82+/-0.28 to 1.94+/-0.26; P < 0.05). But TDS and H/M were more improved in group A than in group B (P < 0.05). LVEF was significantly increased in only group A (from 38+/-6 through 43+/-8 to 49%+/-9%; P < 0.01). NYHA improved in both groups (in group A, from mean 2.5 through 2.1 to 1.8; P < 0.01, in group B, from mean 2.6 to 2.1; P < 0.05) but was more improved in group A than in group B (P < 0.05). CONCLUSION: Cardiac function, symptom and cardiac sympathetic activity evaluated by MIBG images improved after the beta-blocker therapy more than with the treatment that used ACE inhibitors.  (+info)

Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (CD36 deficiency). (2/4352)

CD36 is a multifunctional, 88 kDa glycoprotein that is expressed on platelets and monocytes/macrophages. CD36 also has high homology with the long-chain fatty acid (LFA) transporter in the myocardium. Although platelet and monocyte CD36 levels can indicate a CD36 deficiency, they cannot predict specific clinical manifestations in the myocardium of a given person. We examined the hypothesis that a deficiency in LFA transport augments myocardial glucose uptake in patients with a type I CD36 deficiency. METHODS: Seven fasting patients with a type I CD36 deficiency and 9 controls were assessed by cardiac radionuclide imaging using beta-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) as a LFA tracer and by PET with 18F-fluorodeoxyglucose (FDG). RESULTS: None of the patients with a CD36 deficiency showed myocardial uptake of BMIPP. The percentage dose uptake of BMIPP in these subjects was significantly lower than that in normal controls (1.31+/-0.24 versus 2.90+/-0.2; P < 0.005). PET studies revealed that myocardial FDG accumulation was substantially increased in patients with a CD36 deficiency. Quantitative analysis showed that the percentage dose uptake of FDG in patients with a CD36 deficiency was significantly higher than that in normal controls (1.28+/-0.35 versus 0.43+/-0.22; P< 0.01). CONCLUSION: CD36 functions as a major myocardial LFA transporter and its absence may cause a compensatory upregulation of myocardial glucose uptake.  (+info)

Parametric mapping of cerebral blood flow deficits in Alzheimer's disease: a SPECT study using HMPAO and image standardization technique. (3/4352)

This study assessed the accuracy and reliability of Automated Image Registration (AIR) for standardization of brain SPECT images of patients with Alzheimer's disease (AD). Standardized cerebral blood flow (CBF) images of patients with AD and control subjects were then used for group comparison and covariance analyses. METHODS: Thirteen patients with AD at an early stage (age 69.8+/-7.1 y, Clinical Dementia Rating Score 0.5-1.0, Mini-Mental State Examination score 19-23) and 20 age-matched normal subjects (age 69.5+/-8.3 y) participated in this study. 99mTc-hexamethyl propylenamine oxime (HMPAO) brain SPECT and CT scans were acquired for each subject. SPECT images were transformed to a standard size and shape with the help of AIR. Accuracy of AIR for spatial normalization was evaluated by an index calculated on SPECT images. Anatomical variability of standardized target images was evaluated by measurements on corresponding CT scans, spatially normalized using transformations established by the SPECT images. Realigned brain SPECT images of patients and controls were used for group comparison with the help of statistical parameter mapping. Significant differences were displayed on the respective voxel to generate three-dimensional Z maps. CT scans of individual subjects were evaluated by a computer program for brain atrophy. Voxel-based covariance analysis was performed on standardized images with ages and atrophy indices as independent variables. RESULTS: Inaccuracy assessed by functional data was 2.3%. The maximum anatomical variability was 4.9 mm after standardization. Z maps showed significantly decreased regional CBF (rCBF) in the frontal, parietal and temporal regions in the patient group (P < 0.001). Covariance analysis revealed that the effects of aging on rCBF were more pronounced compared with atrophy, especially in intact cortical areas at an early stage of AD. Decrease in rCBF was partly due to senility and atrophy, however these two factors cannot explain all the deficits. CONCLUSION: AIR can transform SPECT images of AD patients with acceptable accuracy without any need for corresponding structural images. The frontal regions of the brain, in addition to parietal and temporal lobes, may show reduced CBF in patients with AD even at an early stage of dementia. The reduced rCBF in the cortical regions cannot be explained entirely by advanced atrophy and fast aging process.  (+info)

Integrated visualization of functional and anatomic brain data: a validation study. (4/4352)

Two-dimensional SPECT display and three methods for integrated visualization of SPECT and MRI patient data are evaluated in a multiobserver study to determine whether localization of functional data can be improved by adding anatomical information to the display. METHODS: SPECT and MRI data of 30 patients were gathered and presented using four types of display: one of SPECT in isolation, two integrated two-dimensional displays and one integrated three-dimensional display. Cold and hot spots in the peripheral cortex were preselected and indicated on black-and-white hard copies of the image data. Nuclear medicine physicians were asked to assign the corresponding spots in the image data on the computer screen to a lobe and a gyrus and give a confidence rating for both localizations. Interobserver agreement using kappa statistics and average confidence ratings were assessed to interpret the reported observations. RESULTS: Both the interobserver agreement and the confidence of the observers were greater for the integrated two-dimensional displays than for the two-dimensional SPECT display. An additional increase in agreement and confidence was seen with the integrated three-dimensional display. CONCLUSION: Integrated display of SPECT and MR brain images provides better localization of cerebral blood perfusion abnormalities in the peripheral cortex in relation to the anatomy of the brain than single-modality display and increases the confidence of the observer.  (+info)

Using vascular structure for CT-SPECT registration in the pelvis. (5/4352)

The authors outline a method for three-dimensional registration of pelvic CT and 111In-labeled monoclonal antibody capromab pendetide (111In MoAb 7E11.C5) images using 99mTc-labeled red blood cell SPECT data. METHODS: This method of CT-SPECT registration relies on the identification of major blood vessels in the CT and 99mTc SPECT images. The vessels are segmented from the image datasets by outlining them on transverse planar slices using a mouse-based drawing tool. Stacking the transverse outlines provides a three-dimensional representation of the vascular structures. Registration is performed by matching the surfaces of the segmented volumes. Dual isotope acquisition of 111In and 99mTc activities provides precise SPECT-SPECT registration so that registration in three dimensions of the 111In MoAb and CT images is achieved by applying the same transformation obtained from the 99mTc SPECT-CT registration. RESULTS: This method provided accurate registration of pelvic structures and significantly improved interpretation of 111In MoAb 7E11.C5 exams. Furthermore, sites of involvement by prostate cancer suggested by the 111In MoAb examination could be interpreted with the bony and soft tissue (nodal) anatomy seen on CT. CONCLUSION: This method is a general clinical tool for the registration of pelvic CT and SPECT imaging data. There are immediate applications in conformal radiation therapy treatment planning for certain prostate cancer patients.  (+info)

MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates. (6/4352)

This report describes recommended techniques for radiopharmaceutical biodistribution data acquisition and analysis in human subjects to estimate radiation absorbed dose using the Medical Internal Radiation Dose (MIRD) schema. The document has been prepared in a format to address two audiences: individuals with a primary interest in designing clinical trials who are not experts in dosimetry and individuals with extensive experience with dosimetry-based protocols and calculational methodology. For the first group, the general concepts involved in biodistribution data acquisition are presented, with guidance provided for the number of measurements (data points) required. For those with expertise in dosimetry, highlighted sections, examples and appendices have been included to provide calculational details, as well as references, for the techniques involved. This document is intended also to serve as a guide for the investigator in choosing the appropriate methodologies when acquiring and preparing product data for review by national regulatory agencies. The emphasis is on planar imaging techniques commonly available in most nuclear medicine departments and laboratories. The measurement of the biodistribution of radiopharmaceuticals is an important aspect in calculating absorbed dose from internally deposited radionuclides. Three phases are presented: data collection, data analysis and data processing. In the first phase, data collection, the identification of source regions, the determination of their appropriate temporal sampling and the acquisition of data are discussed. In the second phase, quantitative measurement techniques involving imaging by planar scintillation camera, SPECT and PET for the calculation of activity in source regions as a function of time are discussed. In addition, nonimaging measurement techniques, including external radiation monitoring, tissue-sample counting (blood and biopsy) and excreta counting are also considered. The third phase, data processing, involves curve-fitting techniques to integrate the source time-activity curves (determining the area under these curves). For some applications, compartmental modeling procedures may be used. Last, appendices are included that provide a table of symbols and definitions, a checklist for study protocol design, example formats for quantitative imaging protocols, temporal sampling error analysis techniques and selected calculational examples. The utilization of the presented approach should aid in the standardization of protocol design for collecting kinetic data and in the calculation of absorbed dose estimates.  (+info)

Chronic compartment syndrome affecting the lower limb: MIBI perfusion imaging as an alternative to pressure monitoring: two case reports. (7/4352)

Intracompartmental pressure monitoring remains the primary method of diagnosing chronic compartment syndrome. MIBI perfusion imaging is widely available and offers a radionuclear imaging technique for diagnosing this condition. Although the results are not identical with those from pressure monitoring, MIBI may offer a useful screening test for this condition.  (+info)

Prognostic value of myocardial perfusion imaging in patients with high exercise tolerance. (8/4352)

BACKGROUND: Although high exercise tolerance is associated with an excellent prognosis, the significance of abnormal myocardial perfusion imaging (MPI) in patients with high exercise tolerance has not been established. This study retrospectively compares the utility of MPI and exercise ECG (EECG) in these patients. METHODS AND RESULTS: Of 388 consecutive patients who underwent exercise MPI and reached at least Bruce stage IV, 157 (40.5%) had abnormal results and 231 (59.5%) had normal results. Follow-up was performed at 18+/-2.7 months. Adverse events, including revascularization, myocardial infarction, and cardiac death, occurred in 40 patients. Nineteen patients had revascularization related to the MPI results or the patient's condition at the time of MPI and were not included in further analysis. Seventeen patients (12.2%) with abnormal MPI and 4 (1.7%) with normal MPI had adverse cardiac events (P<0.001). Cox proportional-hazards regression analysis showed that MPI was an excellent predictor of cardiac events (global chi2=13.2; P<0.001; relative risk=8; 95% CI=3 to 23) but EECG had no predictive power (global chi2=0.05; P=0.8; relative risk=1; 95% CI=0.4 to 3.0). The addition of Duke's treadmill score risk categories did not improve the predictive power of EECG (global chi2=0.17). The predictive power of the combination of EECG (including Duke score categories) and MPI was no better than that of MPI alone (global chi2=13.5). CONCLUSIONS: Unlike EECG, MPI is an excellent prognostic indicator for adverse cardiac events in patients with known or suspected CAD and high exercise tolerance.  (+info)

TY - JOUR. T1 - Safety of and tolerance to adenosine infusion for myocardial perfusion single-photon emission computed tomography in a Japanese population. AU - Hatanaka, Kunihiko. AU - Doi, Masayuki. AU - Hirohata, Satoshi. AU - Kamikawa, Shigeshi. AU - Kaji, Yoko. AU - Katoh, Tsutomu. AU - Kusachi, Shozo. AU - Ninomiya, Yoshifumi. AU - Ohe, Tohru. PY - 2007. Y1 - 2007. N2 - Background: Adenosine has been available for use in myocardial perfusion single-photon emission computed tomography (SPECT) in Japan since 2005. The purpose of this study was to evaluate the safety of and tolerance to thallium-201 myocardial perfusion SPECT with intravenous adenosine infusion in Japanese patients with suspected coronary artery disease. Methods and Results: Two hundred and six consecutive patients who underwent an adenosine infusion (120•g•·kg-1·min-1) SPECT at Sumitomo Besshi Hospital (Niihama, Japan) were investigated. The effects of adenosine infusion were monitored for each patient. A coronary ...
TY - JOUR. T1 - Are shades of gray prognostically useful in reporting myocardial perfusion single-photon emission computed tomography?. AU - Abidov, Aiden. AU - Hachamovitch, Rory. AU - Hayes, Sean W.. AU - Friedman, John D.. AU - Cohen, Ishac. AU - Kang, Xingping. AU - Yang, Ling De. AU - Thomson, Louise. AU - Germano, Guido. AU - Slomka, Piotr. AU - Berman, Daniel S.. N1 - Copyright: Copyright 2010 Elsevier B.V., All rights reserved.. PY - 2009/7. Y1 - 2009/7. N2 - We have advocated the use of a 5-category normal, probably normal, equivocal, probably abnormal, and definitely abnormal approach to final interpretation of myocardial perfusion single-photon emission computed tomography (SPECT). The prognostic value of expressing levels of certainty compared with a dichotomous normal/abnormal classification or categories for summed stress scores is unclear. Methods and Results-Myocardial perfusion SPECT (MPS) was visually assessed using a standard semiquantitative approach, yielding ...
Methods and Results-We randomized symptomatic women with suspected CAD, an interpretable ECG, and ≥5 metabolic equivalents on the Duke Activity Status Index to 1 of 2 diagnostic strategies: ETT or exercise MPI. The primary end point was 2-year incidence of major adverse cardiac events, defined as CAD death or hospitalization for an acute coronary syndrome or heart failure. A total of 824 women were randomized to ETT or exercise MPI. For women randomized to ETT, ECG results were normal in 64%, indeterminate in 16%, and abnormal in 20%. By comparison, the exercise MPI results were normal in 91%, mildly abnormal in 3%, and moderate to severely abnormal in 6%. At 2 years, there was no difference in major adverse cardiac events (98.0% for ETT and 97.7% for MPI; P=0.59). Compared with ETT, index testing costs were higher for exercise MPI (P,0.001), whereas downstream procedural costs were slightly lower (P=0.0008). Overall, the cumulative diagnostic cost savings was 48% for ETT compared with ...
TY - JOUR. T1 - Prognostic implications of myocardial perfusion single-photon emission computed tomography in the elderly. AU - Hachamovitch, Rory. AU - Kang, Xingping. AU - Amanullah, Aman M.. AU - Abidov, Aiden. AU - Hayes, Sean W.. AU - Friedman, John D.. AU - Cohen, Ishac. AU - Thomson, Louise E.J.. AU - Germano, Guido. AU - Berman, Daniel S.. PY - 2009/12. Y1 - 2009/12. N2 - BACKGROUND- The goal of this study was to assess the clinical value of stress myocardial perfusion scintigraphy (MPS) in elderly patients (,75 years of age). METHODS AND RESULTS: We followed up 5200 elderly patients (41% exercise) after dual-isotope MPS over 2.8±1.7 years (362 cardiac deaths [CDs], 7.0%, 2.6%/y) and a subset with extended follow-up (684 patients for 6.2±2.9 years; 320 all-cause deaths). Survival modeling of CD revealed that both MPS-measured ischemia and fixed defect added incrementally to pre-MPS data in both adenosine and exercise stress patients. Modeling a subset with gated MPS (n=2472) revealed ...
TY - JOUR. T1 - Semi-quantitative ventilation/perfusion scintigraphy and single-photon emission tomography for evaluation of lung volume reduction surgery candidates. T2 - Description and prediction of clinical outcome. AU - Jamadar, David A.. AU - Kazerooni, Ella A.. AU - Martinez, Fernando J.. AU - Wahl, Richard L.. PY - 1999/7/29. Y1 - 1999/7/29. N2 - Ventilation/perfusion scans with single-photon emission tomography (SPET) were reviewed to determine their usefulness in the evaluation of lung volume reduction surgery (LVRS) candidates, and as a predictor of outcome after surgery. Fifty consecutive planar ventilation (99mTc-DTPA aerosol) and perfusion 99mTc-MAA) scans with perfusion SPET of patients evaluated for LVRS were retrospectively reviewed. Technical quality and the severity and extent of radiotracer defects in the upper and lower halves of the lungs were scored from visual inspection of planar scans and SPET data separately. An emphysema index (EI) (extent x severity) for the upper ...
The purpose of the study is to determine the sensitivity and specificity of transcranial duplex scanning (TCD) and single photon emission computer tomography (SPECT) in patients suspected of having Idiopathic Parkinson Disease (PD) or Atypical Parkinson Syndromes (APS) with as golden standard the clinical diagnosis after 2-year follow-up ...
TY - JOUR. T1 - EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2. AU - Kapucu, Özlem L.. AU - Nobili, Flavio. AU - Varrone, Andrea. AU - Booij, Jan. AU - Vander Borght, Thierry. AU - Någren, Kjell. AU - Darcourt, Jacques. AU - Tatsch, Klaus. AU - Van Laere, Koen J.. PY - 2009/12/1. Y1 - 2009/12/1. N2 - These guidelines summarize the current views of the European Association of Nuclear Medicine Neuroimaging Committee (ENC). The purpose of the guidelines is to assist nuclear medicine practitioners when making recommendations, performing, interpreting, and reporting the results of brain perfusion single photon emission computed tomography (SPECT) studies using 99mTc- labelled radiopharmaceuticals. The aim is to achieve a high quality standard for brain perfusion SPECT imaging, which will increase the diagnostic impact of this technique in clinical practice. The present document replaces a former version of the guideline published in 2001 ...
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Brain perfusion SPECT is highly useful for the diagnosis of the dementias, including Alzheimers disease, Fronto-Temporal Dementia, and Lewy Body Disease. Studies of the accuracy of SPECT for diagnosing Alzheimers Disease report sensitivities of 65%-85% and specificities (for other dementias) of 72%-87% (1) In the largest study to date, both HMPAO SPECT and 18F-FDG PETwere able to completely separate 26 AD cases from controls (2) SPECT has been advocated over18F-FDG PET on the basis of its wider availability, lower cost, and perceived better patient tolerability, although a recent review suggested 18F-FDG PET had greater diagnostic accuracy over Brain Perfusion SPECT where available (3) Guidelines of the European Association of Nuclear Medicine and the American College of Radiology endorse the clinical use of Brain Perfusion SPECT in the workup and diagnosis of dementia (4,5).. Brain perfusion SPECT is useful because the clinical diagnosis of dementia is often inaccurate, especially in early ...
Background: Non-invasive diagnostic imaging of atherosclerotic coronary artery disease (CAD) is frequently carried out with cardiovascular magnetic resonance imaging (CMR) or myocardial perfusion single photon emission computed tomography (MPS). CMR is the gold standard for the evaluation of scar after myocardial infarction and MPS the clinical gold standard for ischemia. Magnetic Resonance Imaging (MRI) is at times difficult for patients and may induce anxiety while patient experience of MPS is largely unknown.. Aims: To evaluate image quality in CMR with respect to the sequences employed, the influence of atrial fibrillation, myocardial perfusion and the impact of patient information. Further, to study patient experience in relation to MRI with the goal of improving the care of these patients.. Method: Four study designs have been used. In paper I, experimental cross-over, paper (II) experimental controlled clinical trial, paper (III) psychometric crosssectional study and paper (IV) ...
RATIONALE AND OBJECTIVES: In the general context of perfusion pattern modeling from single-photon emission computed tomographic (SPECT) data, the purpose of this study is to characterize interindividual functional variability and functional connectivity between anatomic structures in a set of SPECT data acquired from a homogeneous population of subjects. MATERIALS AND METHODS: From volume of interest (VOI)-perfusion measurements performed on anatomically standardized SPECT data, we proposed to use correspondence analysis (CA) and hierarchical clustering (HC) to explore the structure of statistical dependencies among these measurements. The method was applied to study the perfusion pattern in two populations of subjects; namely, SPECT data from 27 healthy subjects and ictal SPECT data from 10 patients with mesio-temporal lobe epilepsy (MTLE). RESULTS: For healthy subjects, anatomic structures showing statistically dependent perfusion patterns were classified into four groups; namely, temporomesial
A very simple and low-cost brain dedicated, rapidly rotating Single Photon Emission Tomograph SPECT is described. Its use in following patients with ischemic stroke is illustrated by two middle cerebral artery occlusion cases, one with persistent occlusion and low CBF in MCA territory, and one with early lysis of the occlusion having high CBF (massive luxury perfusion) for some weeks. Evidence of this kind may be essential in the evaluation of therapeutic measures in ischemic stroke. ...
Background: It is of great clinical importance to exclude myocardial infarction in patients with suspected coronary artery disease who do not have stress-induced ischemia. The diagnostic use of myocardial perfusion single-photon emission computed tomography (SPECT) in this situation is sometimes complicated by attenuation artifacts that mimic myocardial infarction. Imaging in the prone position has been suggested as a method to overcome this problem. Methods: In this study, 52 patients without known prior infarction and no stress-induced ischemia on SPECT imaging were examined in both supine and prone position. The results were compared with cardiac magnetic resonance imaging (CMR) with delayed-enhancement technique to confirm or exclude myocardial infarction. Results: There were 63 defects in supine-position images, 37 of which disappeared in the prone position. None of the 37 defects were associated with myocardial infarction by CMR, indicating that all of them represented attenuation ...
Tracking coronary artery disease (CAD) via myocardial perfusion imaging (MPI) may have value in guiding therapeutic management for minimizing coronary event risk. Few studies have evaluated the effects of changes in myocardial perfusion as measured by positron emission tomography (PET MPI) on clinical outcomes. Accordingly, this study identified 552 patients who underwent serial rubidium-82 PET MPI for evaluation of suspected or known CAD. The extent of left ventricular (LV) stress perfusion defects was measured at both scans Objectivesly by automated software as the percentage of the LV mass with ,60% relative perfusion. All patients received aggressive medical therapy and 12% underwent interim revascularization. Mortality information was obtained through the National Death Index with mean follow-up of 2.5 years. Cox models were developed to estimate the effects of changes in stress perfusion defect size (change between serial scans in % of LV with stress perfusion defects) on all-cause and ...
TY - JOUR. T1 - Coronary stenosis severity assessed by 256-slice MDCT angiography in comparison with stress myocardial perfusion imaging. AU - Yonezawa, Masato. AU - Higuchi, K.. AU - Yamazaki, Y.. AU - Jinnouchi, M.. AU - Maruoka, Y.. AU - Isoda, T.. AU - Kamitani, T.. AU - Baba, S.. AU - Matsuo, Y.. AU - Abe, K.. AU - Honda, H.. PY - 2012/1/10. Y1 - 2012/1/10. N2 - We evaluated the feasibility of 256-slice MDCT for detecting coronary artery stenosis without beta blocker premedication, and assessed the diagnostic accuracy of MDCT for detecting myocardial ischemia by 201Tl SPECT. Fifty-three patients underwent both coronary CT angiography and stress myocardial perfusion SPECT. All coronary arteries were assessable with appropriate image quality. MDCT revealed high specificity, but only half of stenotic lesion by MDCT revealed ischemia on SPECT.. AB - We evaluated the feasibility of 256-slice MDCT for detecting coronary artery stenosis without beta blocker premedication, and assessed the ...
Objectives. We sought to evaluate the clinical use and cost-analysis of acute rest technetium-99m (Tc-99m) tetrofosmin single-photon emission computed tomographic (SPECT) myocardial perfusion imaging in patients with chest pain and a normal electrocardiogram (ECG).. Background. Current approaches used in emergency departments (EDs) for treating patients presenting with chest pain and a nondiagnostic ECG result in poor resource utilization.. Methods. Three hundred fifty-seven patients presenting to six centers with symptoms suggestive of myocardial ischemia and a nondiagnostic ECG underwent Tc-99m tetrofosmin SPECT during or within 6 h of symptoms. Follow-up evaluation was performed during the hospital period and 30 days after discharge. All entry ECGs, SPECT images and cardiac events were reviewed in blinded manner and were not available to the admitting physicians.. Results. By consensus interpretation, 204 images (57%) were normal, and 153 were abnormal (43%). Of 20 patients (6%) with an acute ...
For thousands of years, we, as humans, have sought to understand the mechanisms responsible for neural activity (Walsh, 1978). As long ago as 10,000 B.C., craniotomies are known to have been performed. In the 1500s, Vesalius published the first anatomic drawings of the brain after an unprecedented observation and dissection of the brain. In the 19th century, lesion studies introduced the lesion/deficit hypothesis of neural functioning, which subsequently led to much of the current functional neuroanatomical terminology (e.g., Brocas and Wernickes areas). Through the last few decades of what may be considered modern neural research, a greater interest in the cognitive correlates of structural and functional brain lesions has led to the development of todays technology for imaging the nervous system (Mega, 1999, p. 41 ...
Pharmacologic stress with dipyridamole has provided useful diagnostic, as well as prognostic, information in patients undergoing thallium-201 myocardial perfusion imaging. With its ultrashort half-life and a potent and consistent vasodilator effect, adenosine may be the coronary vasodilator of choice with myocardial perfusion imaging.. Fifty-one healthy subjects and 93 patients with suspected coronary artery disease constituted the study group. In this multicenter study the comparative safety and diagnostic efficacy of single-photon emission computed tomography (SPECT) thallium imaging during adenosine-induced coronary hyperemia was compared with exercise treadmill stress. There was a mean increase in heart rate of 37% and a mean decrease in diastolic blood pressure of 5% during the adenosine infusion of 140 μg/kg per min for 6 min. Adenosine infusion was well tolerated in 95% of the subjects. Side effects requiring intervention occurred in seven subjects (5%). None of the subjects experienced ...
DaTscanTM Ioflupane I123, a radiopharmaceutical will be used as an adjunct diagnostic tool in combination with single photon emission computed tomography
Dive into the research topics of Phantom evaluation of simultaneous thallium-201/technetium-99m aquisition in single-photon emission tomography. Together they form a unique fingerprint. ...
Different software tools for quantification of myocardial perfusion SPECT (MPS) studies are routinely used. Several perfusion parameters can be computed automatically. Interpretation of the MPS should start with visual inspection of the rotating planar images, visual analysis of reconstructed SPECT slices and then quantitative analysis to confirm the visual impression. Quantification should be used routinely as complementary to visual analysis. Advantages of quantification are: greater confidence in interpretation, better reproducibility, diagnostic accuracy and measuring the degree of abnormality even subtle changes for serial comparisons. In this review, we look at the common features of such quantitative tools: 17-segment scoring system, polar maps including: raw, severity and extent polar maps, lung-to-heart ratio, transient ischemic dilation ratio, total perfusion deficit and spherecity index.
TY - JOUR. T1 - Cardiac contraction motion compensation in gated myocardial perfusion SPECT. T2 - A comparative study. AU - Salehi, Narges. AU - Rahmim, Arman. AU - Fatemizadeh, Emad. AU - Akbarzadeh, Afshin. AU - Farahani, Mohammad Hossein. AU - Farzanefar, Saeed. AU - Ay, Mohammad Reza. PY - 2018/5/1. Y1 - 2018/5/1. N2 - Introduction: Cardiac contraction significantly degrades quality and quantitative accuracy of gated myocardial perfusion SPECT (MPS) images. In this study, we aimed to explore different techniques in motion-compensated temporal processing of MPS images and their impact on image quality and quantitative accuracy. Material and method: 50 patients without known heart condition underwent gated MPS. 3D motion compensation methods using Motion Freezing by Cedars Sinai (MF), Log-domain Diffeomorphic Demons (LDD) and Free-Form Deformation (FFD) were applied to warp all image phases to fit the end-diastolic (ED) phase. Afterwards, myocardial wall thickness, myocardial to blood pool ...
The evaluation of stress-induced myocardial perfusion defects by non-invasive myocardial perfusion imaging (MPI) modalities has a leading role in the identification of coronary artery disease, and has excellent diagnostic and prognostic value. Non-invasive MPI can be performed using conventional and novel gamma cameras or by PET/CT. New software has allowed novel parameters that may have a role in the identification of early marks of cardiac impairment to be evaluated. We aim to give an overview of niche parameters obtainable by single photon emission CT (SPECT) and PET/CT MPI that may help practitioners to detect initial signs of cardiac damage and identify new therapy targets. In particular, we summarise the role of left ventricular geometry indices for remodelling, phase analysis parameters to evaluate mechanical dyssynchrony, the concept of relative flow reserve in the evaluation of flow-limiting epicardial stenosis, vascular age and epicardial adipose tissue as early markers of atherosclerotic
TY - JOUR. T1 - Gastric accommodation measurements by single photon emission computed tomography and two-dimensional scintigraphy in diabetic patients with upper gastrointestinal symptoms. AU - Chedid, Victor. AU - Halawi, Houssam. AU - Brandler, Justin. AU - Burton, Duane. AU - Camilleri, Michael. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Objective: To compare estimates of gastric accommodation (GA) with single photon emission computed tomography (SPECT) to measurements based on intragastric meal distribution immediately post-meal ingestion (IMD 0 ). Methods: We evaluated 108 diabetics with upper gastrointestinal (UGI) symptoms who had undergone gastric emptying of solids (GE) by scintigraphy and GA measurements by SPECT. Immediately after ingestion of a 99m Tc-labeled egg meal (time 0), we estimated IMD 0 as radioactive counts or area of the proximal half of the stomach on two-dimensional images. Gastric volume (GV) during fasting and after 300 mL Ensure ® was measured by SPECT to quantify ...
Purpose: Shortening scan time and/or reducing radiation dose at maintained image quality are the main issues of the current research in radionuclide myocardial perfusion imaging (MPI). We aimed to validate a new iterative reconstruction (IR) algorithm for SPECT MPI allowing shortened acquisition time (HALF time) while maintaining image quality vs. standard full time acquisition (FULL time). Methods: In this study, 50 patients, referred for evaluation of known or suspected coronary artery disease by SPECT MPI using 99mTc-Tetrofosmin, underwent 1-day adenosine stress 300MBq/rest 900MBq protocol with standard (stress 15min/rest 15min FULL time) immediately followed by short emission scan (stress 9min/rest 7min HALF time) on a Ventri SPECT camera (GE Healthcare). FULL time scans were processed with IR, short scans were additionally processed with a recently developed software algorithm for HALF time emission scans. All reconstructions were subsequently analyzed using commercially available software (QPS/QGS
Few-view single photon emission computed tomography (SPECT - Imaging: PET and SPECT Positron Emission Tomography Single Photon Emission Computed Tomography
Abstract. Background: An analysis of the US National Cardiovascular Data Registry has revealed that only 38% of patients referred for coronary angiography after non-invasive coronary testing have relevant coronary obstruction (CO) (≥70%) of one or more coronary arteries.. Methods: A single-center trial was undertaken in 165 consecutive, symptomatic patients with either known or suspected coronary disease and/or valve disease(VHD) who agreed to undergo cardiac catheterization and coronary angiography if stress myocardial perfusion imaging was abnormal. A total of 116 patients with abnormal SPECT MPI tests, persistent chest pain, or significant VHD underwent final analysis. An MCG coronary obstruction (CO) score of ≥ 4.0 was considered indicative of relevant CO (≥70%) in one or more coronary arteries. Angiographic results were finalized by consensus of two angiographers.. Results: CO (≥70%) was present in 53 of 116 patients (46%). The MCG CO score was significantly higher for patients with ...
Reductions in regional cerebral perfusion, particularly in the posterior temporo-parietal lobes, are well recognized in Alzheimers disease. We set out to correlate perfusion changes, using (99m)Tc-HMPAO single photon emission tomography (SPET), with the pathological stage of Alzheimers disease. The Braak stage of the distribution of neurofibrillary pathology in post-mortem brains was used to classify SPET scans taken in life from a mixed (dementia and control) elderly population into the entorhinal stage (n = 23 subjects), limbic stage (n = 30 subjects) and neocortical stage (n = 36 subjects) Alzheimers disease pathology. The SPET scans were then registered to a common, standard Talaraich space, and single template scans produced for each pathological stage. Comparison of these templates revealed an evolution in the pattern of reduction in regional perfusion. Additional comparisons were performed using earlier SPET scans obtained 5 years before death. For comparisons between templates, a threshold
TY - JOUR. T1 - Comparison of echocardiography with technetium 99m-gated single photon emission computed tomography as diagnostic tools for left ventricular ejection fraction. AU - Choragudi, Nagaraju L.. AU - Prakash, Anita M.. AU - Sun, Ying. AU - Prasad, Paturu. AU - Chiaramida, Salvatore A.. AU - Lucariello, Richard J.. PY - 2001. Y1 - 2001. N2 - Left ventricular ejection fractions (LVEF) are routinely measured and result in critical decision-making algorithms in cardiology. This study was conducted to compare the accepted standard two-dimensional (2-D) echocardiogram ejection fraction (EFECHO) with single photon emission computed tomography rest ejection fraction (EFSPECT). Data were acquired and analyzed from 51 inpatients. EFECHO was obtained using modified Simpsons rule in the four-chamber apical view, and gated EFSPECT was computed by an automated method (Siemens ICON software). Comparison between EFECHO and EFSPECT was done by linear regression, Bland-Altman, and receiver operator ...
In a system which corrects for attenuation artifacts in a SPECT study, a line source is parallel to the axis of rotation of the scintillation camera detector(s) and is scanned in a plane which is parallel to the detector. Advantageously, the line source is initially scanned at high speed across the detector to acquire preliminary transmission CT data and is subsequently scanned across the detector at lower speed to acquire additional transmission CT data. During rescanning, the shuttering of the line source, and/or the speed of the line source, is varied. This acquires transmission CT data which is more reliable and from which the attenuation of the patient may be more accurately calculated.
Background: Coronary artery lesions in Kawasaki disease invasively assessed by coronary angiography. Evaluation of myocardial perfusion by single-photon emission computed tomography may identify the haemodynamic significance of coronary lesions. Obje
TY - JOUR. T1 - In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography. AU - Carlson, Stephanie K.. AU - Classic, Kelly L.. AU - Hadac, Elizabeth M.. AU - Bender, Claire E.. AU - Kemp, Bradley J.. AU - Lowe, Val J.. AU - Hoskin, Tanya L.. AU - Russell, Stephen J.. PY - 2006/11/1. Y1 - 2006/11/1. N2 - Purpose: This study was undertaken to determine the ability of micro-single photon emission computed tomography (micro-SPECT)/computed tomography (CT) to accurately quantitate intratumoral radioisotope uptake in vivo and to compare these measurements with planar imaging and micro-SPECT imaging alone. Procedures: Human pancreatic cancer xenografts were established in 10 mice. Intratumoral radioisotope uptake was achieved via intratumoral injection of an attenuated measles virus vector expressing the NIS gene (MV-NIS). On various days after MV-NIS injection, 123I planar and micro-SPECT/CT imaging was performed. Tumor activity ...
Gilles Barone-Rochette, Mélanie Leclère, Alex Calizzano, Estelle Vautrin, Gallazzini-Crepin Céline, et al.. Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus invasive coronary angiography. Journal of Nuclear Cardiology, Springer Verlag, 2015, 22 (3), pp.513-522. ⟨10.1007/s12350-014-0016-0⟩. ⟨inserm-02440579⟩ ...
Title: Microcirculation Dysfunction: A Possible Mechanism Responsible for Reverse Redistribution in Myocardial Perfusion Imaging?. VOLUME: 5 ISSUE: 4. Author(s):Yong-Ming He and Xiang-Jun Yang. Affiliation:Department of Cardiology, the First Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province, Peoples Republic of China, 215006.. Keywords:Reverse redistribution, single photon emission tomography, coronary artery diseases, mechanism. Abstract: In the past more than one fourth century, the reverse redistribution (RR) phenomenon has been explored extensively and deeply, but its pathogenesis and clinical significances have remained unclear, which has perplexed nuclear specialists and cardiologists in the clinical practice. This paper reviewed the spectrum of the RR phenomenon in different entities and in different radiotracers. A close attention has been paid to the clinical significances, clinical approaching strategies and underlying mechanism of reverse redistribution in coronary ...
Accurate radio-theranostic imaging is becoming more and more important in both preclinical and clinical studies. Until now, only nuclear tracers with energies up to 350 keV could be used for quantitative SPECT imaging. MILabs new Stationary Clustered Pinhole (SCP) SPECT makes it now possible to image nuclear tracers up to 600 keV. This dramatically expands the application field of preclinical imaging for theranostic research: high-energy therapeutic tracers can be imaged directly; the dynamic behavior of radio-therapeutics can be studied; list-mode data enables post-acquisition dose optimization; and above all, the simultaneous acquisition of both SPECT and PET tracers makes it possible to obtain target specific information as well as to assess diseases treatment endpoints.. The authors of this publication demonstrate that the MILabs VECTor PET/SPECT/CT system can obtain images at sub-mm resolution in mice using low-dose 213Bi-labeled octreotate to trace and quantify radioactive uptake in ...
Free Online Library: Evaluating the role of single-photon emission computed tomography in the assessment of neurotologic complaints.(ORIGINAL ARTICLE) by Ear, Nose and Throat Journal; Health, general CAT scans CT imaging Head injuries Nervous system diseases Analysis Research Radiology Radiology, Medical Single photon emission computed tomography Usage SPECT imaging
肺移植後患者に対する肺換気/血流 SPECT/CT を用いた閉塞性細気管支炎症候群の診断的価値に関する検 ...
Noninvasive CT angiography and CT myocardial stress perfusion imaging can adequately predict heart attacks and major adverse cardiovascular events, according to a study published yesterday in Radiology-no invasive coronary angiography (ICA) required.. Invasive coronary angiography (ICA), along with stress tests and single photon emission tomography (SPECT) imaging, has long been the gold standard for making determinations of whether a lesion is hemodynamically significant and likely to result in major adverse cardiovascular events, reads a Radiological Society of North America press release.. But this gold standard has its drawbacks-in costs and risk.. Continue reading CT angiography and stress tests can predict heart attacks. ...
In both groups, patients undergo blood collection on day 0. Patients then undergo full-body single-photon emission-computed tomography (SPECT) scan 4 hours after cell infusion and on day 2. The labeling and imaging process may be repeated after at least 1 course of anticancer treatment.. Cellular uptake is measured by reader/visual interpretation, a semiquantitative grading system, and tumor-to-background uptake ratios.. PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study. ...
NeuroLogica Corporation announced that it received CE Mark approval for its inSPira HD™: portable, high-resolution Single Photon Emission Computed Tom
Research Report on Global Single Photon Emission Computed Tomography (SPECT) Scanner Sales Market Report 2016. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
Single Photon Emission Computed Tomography, a nuclear imaging diagnostic tool helps in accurate assessment of blood flow to organs. It scans images for diagnosis of heart disease and abnormalities.
Diagnostic medical test Single-photon emission computed tomography scan including diseases and symptoms diagnosed or ruled out by this test.
A single photon emission computed tomography system includes a base for supporting a patient and a detector assembly adjacent the field of view. The detector assembly detects photon strikes from the field of view. A photon-blocking member is disposed between the field of view and the detector and has an aperture slot that allows passage of photons aligned with the slot. A collimating assembly includes a plurality of collimating vanes formed of photon-attenuating material. A support assembly supports the collimating assembly and includes a first support member and a second support member with the collimating assembly being disposed therebetween. An adjustment assembly includes a first adjuster operable to adjust a first distance between the collimating assembly and the first support member and a second adjuster operable to adjust a second distance between the collimating assembly and the second support member.
Biological imaging ranges from the visualization of ions, molecules, cells and tissues to the non-invasive imaging of full size animals. The importance of imaging has grown tremendously since the development of methods and markers for live cell imaging, such as green fluorescent proteins confocal microscopy, as well as novel microscopic principles. Different in vivo imaging modalities such as computer tomography (CT), single photon emission computer tomography (SPECT) and magnetic resonance imaging (MRI) has given us tools to visualize structure, metabolism and function in a living body.. Modern imaging requires sophisticated instrumentation for data acquisition and methods of bioinformatics and data handling for their storage and analysis. The prerequisite for live cell imaging is that the equipment is near to the laboratories and animal centres. Therefore, each biocenter has confocal microscopes, video microscopes, and transmission electron microscopes for imaging of cells and tissues. ...
5.4 United States Single Photon Emission Computed Tomography Market Size by Application. …….Request for Sample with [email protected] https://www.researchtrades.com/request-sample/1685956. Who we are. Research Trades has a team of experts who is working on a comprehensive analysis of market research. This estimate is based on a comprehensive study of the future and estimates of future estimates, which can be used by various organizations for growth purposes. We distribute customized reports that focus on meeting the customers specific requirement. Our company provides a large collection of high-quality reports obtained by customer-centered approaches, thus providing valuable research insights.. Contact us ...
TY - JOUR. T1 - Perfusion scintigraphy of the heart and lungs in Ayerzas disease (practical case). AU - Vesnina, Zh V.. AU - Babokin, V. E.. AU - Chernov, V. I.. AU - Krivonogov, N. G.. AU - Sokolov, A. A.. AU - Markov, V. V.. AU - Gulyaev, V. M.. AU - Taranov, S. V.. AU - Lishmanov, Yu B.. PY - 2002. Y1 - 2002. N2 - The potential of perfusion scintigraphy is considered on the basic on the practical case. The patient with the preliminary diagnosis as myocardial ischemia was subjected to the 99mTc single-photon emission computerized tomography of myocardium and the 99mTc perfusion scintigraphy of lung. On the basis of obtained results the clinical diagnosis was thrombophlebitis of lower limbs, infarct-pneumonia, lung hypertension. But the pathologico-anatomic diagnosis was Ayerzas disease. The causes of the diagnostic error are discussed.. AB - The potential of perfusion scintigraphy is considered on the basic on the practical case. The patient with the preliminary diagnosis as myocardial ...
Semantic Scholar extracted view of Correct interpretation of a myocardial perfusion SPECT study in a patient with Ebsteins anomaly through recognition of septal artifact. by Gabriel B. Grossman et al.
Introduction: Asymptomatic diabetic patients are at increased risk of cardiovascular complications. Myocardial perfusion scan may be effective in risk evaluation in this population. Methods: 106 asymptomatic diabetic patients (age: min: 37, max: 82, mean: 57.73±8.88), including 56 females (52.8%) and 50 males (47.2%) were enrolled in the study. Myocardial perfusion scintigraphy was performed by Gated Single Photon Emission Computed Tomography (Gated-SPECT) method. Perfusion and function status was evaluated by qualitative and semi-quantitative parameters. Results: By visual analysis totally 40 out of 106 patients (37.7%) showed abnormal scan. From which, 26(24.5%) showed involvement in one, 13(12.3%) in two, and 1(0.9%) in all three vessel territories. By semi-quantitative method, from 103 patients, 28 (27.2%) were abnormal and 75 (72.8%) were normal. From all the asymptomatic diabetic patients, 11 patients (10.4%) had dilated left ventricles. Transient Ischemic Dilation (TID) was noted in 10
TY - JOUR. T1 - Dual-isotope myocardial perfusion spect with rest thallium-201 and stress Tc-99m sestamibi. AU - Berman, D. S.. AU - Kiat, H.. AU - Van Train, K.. AU - Friedman, J. D.. AU - Fan Ping Wang, Ping Wang. AU - Germano, G.. PY - 1994. Y1 - 1994. N2 - The commercial availability of Tc-99m-labeled myocardial perfusion agents had added choices in the noninvasive clinical assessment of coronary artery disease. Preferential use of Tc-99m sestamibi has been advocated principally due to improved image quality, which results from the combined physical and biological characteristics of this agent. This article reports upon the investigation of another approach for Tc-99m sestamibi SPECT-dual-isotope rest-stress myocardial perfusion SPECT, which takes advantage of the Anger cameras ability to collect date in different energy windows. For the dual- isotope approach, separate radiopharmaceuticals are employed for the rest injection and the stress injection.. AB - The commercial availability of ...
Background-The clinical analysis of myocardial dynamic computed tomography myocardial perfusion imaging lacks standardization. The objective of this prospective study was to compare different analysis approaches to diagnose ischemia in patients with stable angina referred for invasive coronary angiography. Methods and Results-Patients referred for evaluation of stable angina symptoms underwent adenosine-stress dynamic computed tomography myocardial perfusion imaging with a second-generation dual-source scanner. Quantitative perfusion parameters, such as blood flow, were calculated by parametric deconvolution for each myocardial voxel. Initially, perfusion parameters were extracted according to standard 17-segment model of the left ventricle (fully automatic analysis). These were then manually sampled by an operator (semiautomatic analysis). Areas under the receiver-operating characteristic curves of the 2 different approaches were compared. Invasive fractional flow reserve ≤0.80 or diameter ...
TY - JOUR. T1 - Comparison of 123I-MIBG myocardial scintigraphy, brain perfusion SPECT, and voxel-based MRI morphometry for distinguishing between dementia with Lewy bodies and Alzheimers disease. AU - Inui, Yoshitaka. AU - Toyama, Hiroshi. AU - Manabe, Yuta. AU - Sarai, Masayoshi. AU - Iwata, Nakao. PY - 2014/10/16. Y1 - 2014/10/16. N2 - Objective: This study aimed to compare the diagnostic value of 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy, N-isopropyl-p[123I]iodoamphetamine (IMP) brain perfusion single-photon emission computed tomography (SPECT), and brain magnetic resonance imaging (MRI) voxel-based morphometry (VBM) for the differentiation of dementia with Lewy bodies (DLB) and Alzheimers disease (AD).Methods: Thirty-five and 34 patients with probable DLB and probable AD, respectively, were enrolled. All patients underwent 123I-MIBG myocardial scintigraphy, 123I-IMP brain perfusion SPECT, and brain MRI. For 123I-MIBG imaging, we calculated early and delayed ...
Fingerprint Dive into the research topics of Impact of appropriate use on the prognostic value of single-photon emission computed tomography myocardial perfusion imaging. Together they form a unique fingerprint. ...
Ten infants with intractable seizures were examined with fluorodeoxyglucose positron emission tomography, xenon CT and HMPAO single photon emission computed tomography and with anatomical CT and MRI....
PURPOSE To characterize perfusion patterns of periictal single-photon emission tomography (SPECT) in patients with unilateral temporal lobe epilepsy (TLE) and to determine their relationship to the epileptogenic zone (EZ). METHODS We studied periictal SPECT scans of 53 patients after anterior mesial temporal lobectomy who had good seizure outcome after surgery. Ictal SPECT scans were performed during video-EEG monitoring. Typical SPECT patterns consisted of ipsilateral ictal hyperperfusion or ipsilateral postictal hypoperfusion. Atypical ictal patterns included normal scans, bilateral temporal hyperperfusion, or contralateral patterns. These perfusion patterns were retrospectively analyzed searching for concordance rate with the EZ. RESULTS We obtained 51 ictal and two early postictal scans. In the typical group, 40 (75.4%) patients had ipsilateral ictal temporal lobe hyperperfusion, and one (1.9%) patient had ipsilateral postictal temporal lobe hypoperfusion. Twelve (22.7%) patients exhibited
TY - JOUR. T1 - Perfusion vector-a new method to quantify myocardial perfusion scintigraphy images: a simulation study with validation in patients.. AU - Minarik, David. AU - Senneby, Martin. AU - Wollmer, Per. AU - Mansten, Alva. AU - Sjöstrand, Karl. AU - Edenbrandt, Lars. AU - Trägårdh, Elin. PY - 2015. Y1 - 2015. N2 - The interpretation of myocardial perfusion scintigraphy (MPS) largely relies on visual assessment by the physician of the localization and extent of a perfusion defect. The aim of this study was to introduce the concept of the perfusion vector as a new objective quantitative method for further assisting the visual interpretation and to test the concept using simulated MPS images as well as patients.. AB - The interpretation of myocardial perfusion scintigraphy (MPS) largely relies on visual assessment by the physician of the localization and extent of a perfusion defect. The aim of this study was to introduce the concept of the perfusion vector as a new objective ...
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This is the third in a series of papers using identical methodology to evaluate adherence to AUC for SPECT imaging in a single institution. The first publication dealt with patients from 2005 and demonstrated a substantial (14.4%) prevalence of inappropriate studies and furthermore identified four separate indications accounting for 88% of inappropriate studies including asymptomatic low-risk patients, which accounted for almost 50% of the inappropriate studies. A follow-up after publication of the AUC in 2006 demonstrated a significant decrease to 7.0% of inappropriate studies. The authors, at that time, engaged in a quality improvement project including grand rounds, publication of one page synopses of these studies, and other intramural educational activities designed to educate the referring physician base, and presumably further decrease the incidence of inappropriate studies. These educational and information sessions occurred predominantly in January 2008, and a third cohort of patients ...
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We evaluated the feasibility of interictal single photon emission computed tomography (SPECT) to detect alterations in regional cerebral blood flow and neuronal activity in dogs with idiopathic epilepsy. Twelve dogs with idiopathic epilepsy underwent interictal technetium-99m-ethyl cysteinate dimer SPECT of the brain. Different cortical regions of interest (ROIs), 1 ROI at the cerebellum and 1 ROI at the subcortical area were evaluated by semiquantitative analysis and compared with a control group (18 dogs). Significant hypoperfusion (P=0.02) was present in the subcortical area of epileptic dogs. This hypoperfusion was not associated with seizure frequency, age at onset of seizures, duration of epilepsy, or time since the last seizure. Interictal SPECT did not reveal cortical or cerebellar perfusion alterations. The subcortical area may play an important role in the pathophysiology of canine idiopathic epilepsy. ...
objective: to investigate the pattern of perfusion abnormalities in ictal and interictal brain perfusion spect images (bsi) from patients with temporal lobe epilepsy (tle). method: it was acquired interictal and ictal bsi from 24 patients with refractory t...
BACKGROUND: We evaluated the effects of attenuation correction and reconstruction techniques on the detection of hypoperfused lesions in brain SPECT imaging. METHODS: A software phantom was constructed using the data available on the BrainWeb database by assigning activity values to grey and white matter. The true attenuation map was generated by assigning attenuation coefficients to six different tissue classes to create a non-uniform attenuation map. The uniform attenuation map was calculated using an attenuation coefficient of 0.15 cm. Hypoperfused lesions of varying intensities and sizes were added. The phantom was then projected as typical SPECT projection data, taking into account attenuation and collimator blurring with the addition of Poisson noise. The projection data were reconstructed using four different methods: filtered back-projection in combination with Changs first-order attenuation correction using the uniform or the true attenuation map and maximum likelihood iterative ...
Objectives: Soft tissue attenuation artifacts are the most common cause of false-positives in myocardial perfusion SPECT (MPS). Few studies assessing the value
TY - JOUR. T1 - Myocardium perfusion scintigraphy in evaluation of endovascular treatment results of coronary artery disease. AU - Lishmanov, Yu B.. AU - Vesoina, J. V.. AU - Rybalchenko, E. V.. AU - Krylov, A. L.. PY - 2004. Y1 - 2004. N2 - Purpose: To determine abilities and principal features of prospective scintigraphic evaluation of endovascular treatment results of coronary artery disease (CAD) using thallium-199 perfusion single-photon emission computed tomography. Material and methods: Forty CAD patients were investigated by perfusion scintigraphy before and 2-3 weeks, 3-6 months and 1-2 years after coronary artery stenting. The character and size of perfusion defects and presence of the reverse radionuclide redistribution phenomenon were estimated. Results: The coronary stenting almost results to the 80 % decrease of mean size of transitory ischemic zones. The presence of reversible perfusion defects after operation was bound up with the incomplete revascularization or with X-syndrome. ...
Cardiovascular events remain one of the most frequent causes of mortality and morbidity worldwide. The majority of cardiac events occur in individuals without known coronary artery disease (CAD) and in low- to intermediate-risk subjects. Thus, the development of improved preventive strategies may substantially benefit from the identification, among apparently intermediate-risk subjects, of those who have a high probability for developing future cardiac events. Cardiac computed tomography and myocardial perfusion scintigraphy (MPS) by single photon emission computed tomography may play a role in this setting. In fact, absence of coronary calcium in cardiac computed tomography and inducible ischaemia in MPS are associated with a very low rate of major cardiac events in the next 3-5 years. Based on current evidence, the evaluation of coronary calcium in primary prevention subjects should be considered in patients classified as intermediate-risk based on traditional risk factors, since high calcium ...
Myocardial Perfusion Imaging is used to diagnose, and estimate the prognosis of patients with coronary artery disease. Increased attention around the use radiation in medical imaging coupled with new software allows the opportunity to try and reduce the radiation perfusion imaging by half. Software advances allow us to process images that have less radiation counts in the heart without losing the ability to determine the degree of heart disease. Patients underwent a usual dose and low dose stress myocardial perfusion technetium 99m study at the Ottawa Heart Institute. There were no significant differences between the images. The image quality and the parameters used determine significant heart disease were similar. We became an early adopter of the low dose studies and now routinely perform this on our patients. We also followed the first cohort of patients for 12 months to ensure that we saw no problems with doing a low dose test in the long term. Although we did not collect data on all of the ...
Fingerprint Dive into the research topics of Segmentation of the left ventricle in myocardial perfusion SPECT using variational level set formulation. Together they form a unique fingerprint. ...
Prognosis in patients with suspected or known ischemic heart disease and normal myocardial perfusion: Long-term outcome and temporal risk ...
The methods were validated and they have already been taken into use in hospitals all over the world. Coronary artery disease is the most common cause of death in the world, and a major cause of hospitalisation. Myocardial perfusion imaging (MPI), which is used to assess the sufficiency of myocardial blood flow, is an important tool in the diagnostics of coronary artery disease and in determining its severity. The scan is usually performed in two phases involving a stress myocardial perfusion imaging scan and a rest myocardial perfusion imaging scan. The patient is given an injection of a radioactive substance, which gets absorbed in those parts of the heart muscle that have normal blood flow. The scan is performed by using a gamma camera which detects radiation coming from the patient. The quality of images obtained by MPI are dependent on a variety of factors, the most significant ones being image noise, photon attenuation, Compton scattering, collimator-detector response (CDR), and patient ...
Abstract: : Purpose:To determine the effects of chronic retinal hypoperfusion on the physiological and morphological properties of the rat retina. Methods: Chronic retinal hypoperfusion was induced by unilateral and bilateral ligation of the common carotid arteries in anesthetized Long-Evans and Sprague-Dawley rats. Electroretinograms (ERGs) elicited by different stimulus intensities were recorded and histopathological studies performed up to 4 weeks postligation. Results: Injection of India ink in the heart demonstrated perfusion of both retinas following bilateral ligation. The a- and b-waves of the ERGs were significantly depressed by about 50% in the bilateral and unilateral (ipsilateral) ligated animals, although the thresholds were not as altered. The b-waves were more affected than the a-wave so that the b/a wave ratio was less than 1.0, a negative type ERG. There was a progressive decrease in the a- and b-waves with increasing postligation times. The thickness of the outer nuclear layer ...
Uniformly redundant array coded apertures have proven to be useful in the design of collimators for x-ray astronomy. They were initially expected to be equally successful in single-photon emission computed tomography (SPECT). Unfortunately, the SPECT images produced by this collimator contain artifacts, which mask the true picture and can lead to false diagnosis. Monte Carlo simulation has shown that the formation of a composite image will significantly reduce these artifacts. A simulation of a tumor in a compressed breast phantom has produced a composite image, which clearly indicates the presence of a 5 mm × 5 mm × 5 mm tumor with a 6:1 intensity ratio relative to the background tissue.. © 2002 Optical Society of America. Full Article , PDF Article ...
This Thesis investigates near infrared ( ~ 1550 nm) time-correlated singlephoton counting, studying the single-photon detectors and some of the potential application areas. Custom designed and fabricated InGaAs/InP single-photon avalanche diode detectors were characterised. Our devices yielded single-photon detection efficiencies of ~10 %, timing jitter of 200 ps, and noise equivalent power comparable to the best commercially available avalanche photodiodes operated in Geiger-mode. The afterpulsing phenomenon which limits the maximum count rate of InGaAs/InP single-photon avalanche diodes has been investigated in detail and activation energies calculated for the traps that cause this problem. This was found to be ~250 meV for all the devices tested, despite their differing structures and growth conditions, and points to the InP multiplication region as the likely location of the traps. Ways of reducing the effects caused by the afterpulsing phenomenon were investigated and sub-Geiger mode ...
The use of radionuclides has become more and more common in the diagnosis and therapy of cancer. Targeted radionuclide diagnostics and therapy based on the combination of appropriate radionuclides with selective delivery systems (e.g. antibody, peptides etc.) maximizes precision of the imaging as well as minimizes the damage of healthy tissues during therapy. Several imaging modalities using radionuclides including Single Photon Emission Tomography (SPECT) and Positron Emission Tomography (PET) can be applied for non-invasive cancer visualization. Furthermore, based on imaging (tumor sizes and locations), appropriate therapeutic radionuclides emitting alpha, beta- particles or auger electrons can be utilized. This combination of radionuclides for diagnostics (imaging) and therapy by using the same delivery systems, named theranostic, has become state of the art in nuclear medicine. To broaden the number of radionuclides that can be applied in combination with organic delivery systems, ...
No model of brain function, including memory, will be complete until it can account for, and fully incorporate, the rare but spectacular condition of savant syndrome. In the past decade, particularly, much progress has been made towards explaining this jarring juxtaposition of ability and disability, but many unanswered questions remain. However, interest in this fascinating condition is accelerating, especially since the discovery of savant-type skills in previously unimpaired older persons with FTD and other acquired savant instances. This finding has far-reaching implications regarding buried potential in some or, perhaps, all of us.. Advanced technologies will help in those investigations. Computed tomography (CT) and MRI provide stunningly high-resolution images of all the brain architecture, surface and deep, permitting detailed inspection of brain structure. However, studies of brain function, such as positron emission tomography (PET), single photon emission CT (SPECT) or functional MRI, ...
This study validates estimation of EDV, ESV, and LVEF using ECTB, 4D-MSPECT, and QGS with cMRI as the gold standard and with gated SPECT and cMRI conducted under resting nonpost-stress conditions within a very close time interval. Seventy patients who were representative of the heterogeneous clinical coronary artery disease spectrum with the typical age range were included. To preclude significant changes in physiologic status between the resting examinations, cMRI in our study was either performed directly before gated 99mTc-MIBI SPECT or subsequent to it. The results assessed with ECTB were further compared with those obtained with 4D-MSPECT and QGS.. cMRI was chosen as the method of reference because it represents the accepted standard for measuring global function (21). Volumetric accuracy was ensured by high tissue contrast facilitating endocardial border definition (22,24). Nevertheless, it must be kept in mind that the 2-dimensional short-axis slices are acquired separately, not ...
Nuclear medicine Pet/Spect. Chapters 18 to 22. Activity. Number of radioactive atoms undergoing nuclear transformation per unit time. Change in radioactive atoms N in time dt Number of radioactive atoms decreases with time (- minus sign). Activity. Expressed in Curie Slideshow 83492 by...
Lowering the administered dose in SPECT myocardial perfusion imaging (MPI) has become an important clinical problem. In this study we investigate the potential benefit of applying a deep learning (DL) approach for suppressing the elevated imaging noise in low-dose SPECT-MPI studies. We adopt a supervised learning approach to train a neural network by using image pairs obtained from full-dose (target) and low-dose (input) acquisitions of the same patients. In the experiments, we made use of acquisitions from 1,052 subjects and demonstrated the approach for two commonly used reconstruction methods in clinical SPECT-MPI: 1) filtered backprojection (FBP), and 2) ordered-subsets expectation-maximization (OSEM) with corrections for attenuation, scatter and resolution. We evaluated the DL output for the clinical task of perfusion-defect detection at a number of successively reduced dose levels (1/2, 1/4, 1/8, 1/16 of full dose). The results indicate that the proposed DL approach can achieve substantial noise
Non-invasive images of the myocardium that reflect myocardial perfusion can be obtained either by using conventional nuclear medicine radiopharmaceuticals and cameras or by positron emission tomography (PET). Myocardial perfusion scintigraphy (MPS) with thallium-201 and/or technetium (Tc)-99m-labelled sestamibi and tetrofosmin, in combination with single photon emission computed tomography (SPECT), is a robust and well validated technique for the identification of myocardial ischaemia and infarction with high sensitivity and specificity. 99mTc-labelled myocardial perfusion agents have a high-count density which enables acquisition of electrocardiogram-gated images. Spatial and temporal changes in activity during the cardiac cycle reflect regional myocardial motion and thickening and this technique
PURPOSE: Ischaemic myocardial dysfunction shows different time courses of functional recovery according to the pathophysiological characteristics of the dysfunction. In this study, we investigated the time course of functional recovery according to the preoperative reversibility of perfusion impairment on myocardial single-photon emission computed tomography (SPECT) after revascularisation surgery. METHODS: Forty-eight patients (42 men and 6 women; mean age 59+/-9 years) who underwent revascularisation surgery were included in the study. 201Tl rest/dipyridamole stress (99m)Tc-sestamibi gated SPECT was performed 10+/-8 days before (preoperative), 105+/-13 days after (early follow-up) and 497+/-66 days after (late follow-up) surgery. Using a 20-segment model, segmental perfusion and thickening were quantified with automatic software. As an indicator of the reversibility of perfusion impairment, a reversibility score (RevS) was defined as a measure of rest minus stress perfusion values. Segmental ...
The work, which is being done under the title Project ProSPECTus, will be based on single photon emission computed tomography (SPECT) imaging - a technique that detects gamma rays emitted from a small amount of a radioactive pharmaceutical injected into the body.. Conventionally, an Anger Camera is used to do this. This camera relies on a collimator to filter some of the gamma rays through and to build a picture of the inner biological process of the patient.. However, ProSPECTus has taken a different approach by using what is known as the Compton Camera. This identifies the origin of the gamma rays without the use of a collimator, resulting in much less radiation being emitted during the process.. Dr Andy Boston, project spokesperson for Liverpool University, said that, because the radiation is used more efficiently, the sensitivity of the camera is improved, allowing the dose of radiation administered to the patient to be increased.. He added: [The technology] is unique in that it will ...
Recent advances in nuclear myocardial perfusion imaging (MPI) have made it possible to develop a dual-isotope protocol for high-speed acquisition with image quality and radiation delivery comparable to that obtained with conventional single isotope p
Myocardial perfusion imaging (MPI) is a commonly used diagnostic modality for risk stratification in patients with known or suspected coronary artery
OBJECTIVES: Although the prognostic value of quantitative single photon emission computed tomography myocardial perfusion imaging (MPI) with exercise and pharmacologic stress is well established, the prognostic and management value in the Medicare age population is less clear.. METHODS: The prospectively populated Cleveland Clinic nuclear cardiology database was used to identify 5,994 consecutive pateints, age ,65 years [1,664 (28%) exercise MPI, mean age 72.4±5.1, 74% male], who underwent MPI between January 2004 and January 2008. Clinical baseline variables, post test 90 days revascularization and MPI variables were analyzed. Overall and stratified nonparametric survival estimates were obtained by Kaplan-Meier method. Median follow-up time was 2.4 years. Parametric hazard modeling with bootstrap bagging methods was used to determine prognostic variables predicting mortality.. RESULTS: There was no difference in mortality in patients with an abnormal MPI vs. those with normal MPI. Amongst ...
SPECT myocardial perfusion imaging (MPI) is the most validated non-invasive method to test for ischemia, and this procedure is performed over 15 to
Introduction. Considerable doubt remains about whether the warm-up effect in angina represents ischaemic preconditioning (IPC), or is simply due to improved myocardial perfusion via acute recruitment of collaterals. We investigated the latter possibility using quantitative tetrofosmin SPECT. Methods. 11 patients (age 63±8 years, 8 male) with coronary disease and preserved left ventricular function underwent symptom-limited treadmill exercise off antianginal medication. On three separate days at weekly intervals, 99m Tc-tetrofosmin 400-450MBq was injected at rest, during a single exercise test (Ex1), and during the second of two exercise tests separated by 30 minutes (Ex2a and Ex2b). Exercise injections were given at equivalent heart rates. SPECT acquisitions were obtained 1-2 hours after each tetrofosmin injection. Quantitative analysis was performed by comparing polar plots derived from radial slices with a normal database. The hypoperfusion index was the product of
In a recent prospective, double-blind, randomized multicenter phase 3 trial, ADVANCE (Adenosine versus Regadenoson Comparative Evaluation for Myocardial Perfusion Imaging), the A2A selective adenosine receptor agonist, regadenoson, was shown to be noninferior to the nonselective vasodilator, adenosine, for detecting myocardial ischemia (1). The overall visual agreement was comparably low (in the low 60% range) for the adenosine-regadenoson and for the adenosine-adenosine comparisons. Conversely, when quantitative analysis was applied, regadenoson induced virtually identical results to adenosine-regarding the size and severity of left ventricular perfusion defect size and extent of ischemia (2). What are the regulatory implications of these findings? Should the regulatory bodies rely on subjective visual interpretation of myocardial perfusion studies, on objective quantitative programs to appraise the comparability between vasodilators, or both? What is the true standard?. In order to avoid the ...
Single photon emission computed tomography (SPECT)Edit. Single photon emission computed tomography (SPECT), a nuclear medicine ... Computed tomography (CT)Edit. Coronary Computed Tomography Angiography (CCTA)Edit. Image of contrast enhanced dual-source ... Positron emission tomography (PET)Edit. Positron emission tomography (PET), a nuclear medicine imaging methodology for positron ... Computed tomography angiography (CTA), an imaging methodology using a ring-shaped machine with an X-Ray source spinning around ...
Single-photon emission computed tomography and Positron emission tomography. SPECT and PET use radioactive isotopes, which are ... Single-unit recording Direct brain stimulation Animal models Postmortem studies Cognitive science has given rise to models of ... tenet of cognitive science is that a complete understanding of the mind/brain cannot be attained by studying only a single ...
Schinkel AF, Valkema R, Geleijnse ML, Sijbrands EJ, Poldermans D (May 2010). "Single-photon emission computed tomography for ... Hulten EA, Carbonaro S, Petrillo SP, Mitchell JD, Villines TC (March 2011). "Prognostic value of cardiac computed tomography ... May 2017). "Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below ... although the single nucleotide polymorphisms that are implicated are within a non-coding region. The majority of these variants ...
Single photon emission computed tomography (SPECT) images may also be acquired. In some imaging centers, SPECT images may be ... while the positron emission of gallium 68 is imaged by positron emission tomography (PET). Gallium salts are taken up by tumors ... In the past, the gallium scan was the gold standard for lymphoma staging, until it was replaced by positron emission tomography ... It is indicated for positron emission tomography (PET) of prostate specific membrane antigen (PSMA) positive lesions in men ...
ST = Single-photon Emission Computed Tomography. *TG = Thermography. *US = Ultrasound. *VF = Videofluorography (retired) ...
Single-photon computed tomography and positron-emission tomography". Breast Cancer Research. 7 (4): 153-62. doi:10.1186/bcr1201 ... Time-correlated single photon counting is fundamental to cope with the low-level output signal. In frequency-domain ... Finally, the signal processor could be a device for Time-correlated single photon counting in the case of a time-resolved ... photon transport in biological tissue Near-infrared window in biological tissue Time-domain diffuse optics Computed tomography ...
March 2008). "Single photon emission computed tomography and magnetic resonance imaging evaluation in SLE patients with and ... Although studies using MRI or single-photon emission computed tomography (SPECT) often find abnormalities, the value of these ... November 2006). "Migraine during systemic lupus erythematosus: findings from brain single photon emission computed tomography ... January 1995). "Brain single-photon emission tomography with 99mTc-HMPAO in neuropsychiatric systemic lupus erythematosus: ...
Rather, single-photon emission computed tomography (SPECT) is more common in the US. With multihead SPECT systems, imaging can ... The positron emission tomography (PET) tracer nitrogen-13 ammonia, though less widely available, may offer significantly ... Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons ...
Analytical techniques, much like the reconstruction of computed tomography (CT) and single-photon emission computed tomography ... ultrasound and single-photon emission computed tomography (SPECT).. While some imaging scans such as CT and MRI isolate organic ... An application to single photon emission tomography". Proceedings Amererican Statistical Computing: 12-18.. ... 2010). "Clinical value of 18F-fluorodihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA PET/CT) ...
Single-photon emission computed tomographyEdit. Single-photon emission computed tomography (SPECT) is similar to PET and uses ... Positron emission tomographyEdit. Positron emission tomography (PET) and brain positron emission tomography, measure emissions ... the development of radioligands allowed single photon emission computed tomography (SPECT) and positron emission tomography ( ... Computed axial tomographyEdit. Main article: CT head. Computed tomography (CT) or Computed Axial Tomography (CAT) scanning uses ...
Assessment with xenon 133 single-photon emission computed tomography and the Tower of London". Archives of General Psychiatry. ... This finding was confirmed in subsequent studies using the improved spatial resolution of positron emission tomography with the ... Buchsbaum, Monte S. (1982). "Cerebral Glucography With Positron Tomography". Archives of General Psychiatry. 39 (3): 251-9. doi ...
Preclinical or small-animal Single Photon Emission Computed Tomography (SPECT) is a radionuclide based molecular imaging ... "Advances in Pinhole and Multi-Pinhole Collimators For Single Photon Emission Computed Tomography Imaging". World Journal of ... SPECT tracer emits single γ-photons with the energy of photons that depends on the isotope that was used for radiolabeling. In ... Iterative reconstruction techniques in emission computed tomography. Phys Med Biol. 2006; 51(15):R541-78. Lange K, et al. EM ...
Single Photon Emission Computed Tomography). Another medical scintillography technique, the Positron-emission tomography (PET ... In contrast, SPECT and positron emission tomography (PET) form 3-dimensional images, and are therefore classified as separate ... Detectors coated with materials which scintillate when subjected to gamma rays are scanned with optical photon detectors and ...
... a single photon emission computed tomography study". Brain. 122 (Pt 7): 1271-82. doi:10.1093/brain/122.7.1271. PMID 10388793. ... Excitability changes in PD due to tDCS is not seen at greater extent with differential MEP amplitudes checked at M1 with single ...
"Myocardial Perfusion Imaging with Combined Single-photon Emission Computed Tomography and Multislice Computed Tomography". ... 25 May 2018). "Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, ... An electrocardiogram (ECG) guides the image acquisition, and the resulting set of single-photon emission computed tomography ( ... Fathala, Ahmed (April 2011). "Myocardial perfusion single photon computed tomography: An Atlas". Journal of the Saudi Heart ...
There he began work on single-photon emission computed tomography and non-invasive cardiac imaging. In 1983, Pettigrew ... including an effort to reduce the radiation dose patients receive in routine computed tomography (CT), building a national ...
... including single-photon emission computed tomography (SPECT), positron emission tomography (PET) and scintigraphy. The urea ... The emitted 159 keV gamma ray is used in single-photon emission computed tomography (SPECT). A 127 keV gamma ray is also ... It is used in positron emission tomography. 18F decays predominately by β emission, with a half-life of 109.8 min. It is made ... 4He 13N is used in positron emission tomography (PET scan). 15O decays by positron emission with a half-life of 122 sec. ...
... : review of the literature and case report with ictal single photon emission computed tomography. Epilepsia ...
Review of the Literature and Case Report with Ictal Single Photon Emission Computed Tomography". Epilepsia. 38 (2): 200-207. ...
Following an intravenous injection of Prostascint, imaging is performed using single photon emission computed tomography (SPECT ...
The Fly Algorithm has been successfully applied in single-photon emission computed tomography and positron emission tomography ... Single-photon emission computed tomography (SPECT) reconstruction Positron emission tomography (PET) reconstruction Digital art ... Positron Emission Tomography reconstruction. Cooperative coevolution is a broad class of evolutionary algorithms where a ... Another application field of the Fly Algorithm is reconstruction for emission Tomography in nuclear medicine. ...
Single-photon emission computed tomography (SPECT) showed hypoperfusion, or decreased blood flow, in the right frontoparietal ...
Radioligands are either single photon or positron emitters. This is how single photon emission computed tomography (SPECT) and ... and computed tomography (CT) were developed in the 1970s and 1980s. The new MRI and CT technologies were considerably less ... positron emission tomography (PET) got their names. While the first human positron imaging device was developed by Gordon ... The end result allows researchers to map things as big as geological core samples or as small as single cells.[citation needed ...
"Regional Cerebral Blood Volume and Hematocrit Measured in Normal Human Volunteers by Single-Photon Emission Computed Tomography ... single inhalation is a reliable and accurate blood tracer for measuring cerebral blood volume with emission computed tomography ... In vivo studies using emission computed tomography gave coefficients of variation for regional cerebral blood volume and cross- ... Synchrotron Radiation Computed Tomography uses a monochromatic and parallel X-ray beam to measure the value of cerebral blood ...
Single photon emission computed tomography (SPECT) is a nuclear medicine imaging technique using gamma rays. It may be used ... although the number of gammas emitted results in radiation doses more comparable to X-ray studies like computed tomography. ... because it emits readily detectable gamma rays with a photon energy of 140 keV (these 8.8 pm photons are about the same ... Pure gamma emission is the desirable decay mode for medical imaging because other particles deposit more energy in the patient ...
Hexamethylpropyleneamine oxime single-photon emission computed tomography (HMPAO SPECT) demonstrated hypoperfusion of the ... It is also suggested to be a type of body dysmorphic disorder or, as it involves a single delusional belief, some suggest that ... High proportions of ORS patients are unemployed, single, and not socially active. The average age reported is around 20-21 ...
... blood flow and cerebral hematocrit in patients with cerebral ischemia measured by single-photon emission computed tomography". ... In fact, it has been shown that, following a single paired-avoidance paradigm in mice, LTP can be recorded in some hippocampal ... The calcium entry also phosphorylates CaMKII, which phosphorylates AMPARs, increasing their single-channel conductance. The ... and increases their single channel conductance. The T840 site was more recently discovered, and has been implicated in LTD. ...
Amen advocates the use of (single photon emission computed tomography SPECT) imaging for diagnostic purposes.[7] His marketing ... Amen's practices use single-photon emission computed tomography, or SPECT, scans of brain activity in an attempt to compare the ... on Brain Imaging and Child and Adolescent Psychiatry With Special Emphasis on Single Photon Emission Computed Tomography (SPECT ...
Computed tomography (CT) technologies include X-ray CT, positron emission tomography (PET) and single-photon emission computed ... Magnetic resonance imaging (MRI) and computed tomography (CT) scans are the most commonly used imaging technologies for ... or computed tomography (CT), or after analysis of a biopsy. Below is a list of the most common pediatric CNS- tumors ( ... tomography (SPECT). X-ray CT scans take many X-ray measurements from different angles to produce virtual "slices" of specific ...
Single photon emission computed tomography (SPECT) assessments may also be conducted pre and post treatment, depending on the ...
Analytical techniques, much like the reconstruction of computed tomography (CT) and single-photon emission computed tomography ... An application to single photon emission tomography" (PDF). Proceedings Amererican Statistical Computing: 12-18.. ... ultrasound and single-photon emission computed tomography (SPECT). While some imaging scans such as CT and MRI isolate organic ... A similar imaging process to PET is single-photon emission computed tomography (SPECT), which also uses radioligands to detect ...
Magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) are two of the tests that can identify ... single-tier IgG (old infection) Western blot.[227] Previously, the CDC only included laboratory evidence based on (1) and (2) ... a single dose of doxycycline administered within the 72 hours after removal may reduce the risk of Lyme disease. It is not ... a single dose of doxycycline may be used to prevent development of infection, but is not generally recommended since ...
... single-photon emission computed tomography (SPECT) 3-73: single-photon emission computed tomography with computed tomography ( ... positron emission tomography (PET) with full-ring scanner 3-75: positron emission tomography with computed tomography (PET / CT ... computed tomography (CT) 3-30...3-30: optical techniques 3-60...3-69: representation of the vascular system 3-70...3-76: ...
Single-photon emission (SPECT). *Positron-emission tomography (PET). Therapy. *Fast-neutron. *Neutron capture therapy of cancer ... With Godfrey Hounsfield's invention of computed tomography (CT) in 1971, three-dimensional planning became a possibility and ... In photon therapy, most of the radiation effect is through free radicals. Cells have mechanisms for repairing single-strand DNA ... in the 1970s and positron emission tomography (PET) in the 1980s, has moved radiation therapy from 3-D conformal to intensity- ...
3D / ECT(英语:emission computed tomography). *SPECT(英语:Single-photon emission computed tomography) *gamma ray: Myocardial ... Quantitative computed tomography(英语:Quantitative computed tomography). *Spiral computed tomography(英语:Spiral computed ... Computed tomography of the heart. *Computed tomography of the abdomen and pelvis(英语:Computed tomography of the abdomen and ... Computed tomography of the head(英语:Computed tomography of the head) ...
... positron emission tomography)(PET) தனி ஒளியன் உமிழ்வு கணிப்புத் பிரித்துவரைவியல் (Single-photon emission computed tomography( ( ... Roobottom CA, Mitchell G, Morgan-Hughes G (November 2010). "Radiation-reduction strategies in cardiac computed tomographic ...
Computed tomography of the head. *Quantitative computed tomography. *Spiral computed tomography. *High resolution CT ... Stimulated emission depletion microscope. *Super-resolution microscopy. *Two-photon excitation microscopy: Although they use a ... Imaging frame rates are typically slower for single point laser scanning systems than spinning-disk or PAM systems. Commercial ... From this evolved the single plane illumination microscope. Additionally deconvolution may be employed using an experimentally ...
... positron emission tomography (PET), single-photon emission tomography (SPECT). CT scans and MRI are the two techniques widely ... "Is cranial computed tomography unnecessary in children with a head injury and isolated vomiting?". BMJ. 365: l1875. doi:10.1136 ... "Is cranial computed tomography unnecessary in children with a head injury and isolated vomiting?". BMJ. 365: l1875. doi:10.1136 ... Computed tomography (CT) has become the diagnostic modality of choice for head trauma due to its accuracy, reliability, safety ...
Computed Tomography, better known as C.T. Scans or CAT Scans have made an enormous contribution to medicine, however not ... Compared to single-material shielding, the same mass of graded-Z shielding has been shown to reduce electron penetration over ... For example, although high atomic number materials are very effective in shielding photons, using them to shield beta particles ... Electromagnetic radiation consists of emissions of electromagnetic waves, the properties of which depend on the wavelength. ...
Redirected from Single photon emission computed tomography). Single-photon emission computed tomography (SPECT, or less ... Wikimedia Commons has media related to Single photon emission computed tomography.. *Human Health Campus, The official website ... Single-photon emission computed tomography. A SPECT slice of the distribution of technetium exametazime within a patient's ... "D. Boulfelfel, R.M. Rangayyan, L.J. Hahn, R. Kloiber, Restoration of Single Photon Emission Computed Tomography Images". ...
Single-photon emission (SPECT). *Positron-emission tomography (PET). Therapy. *Fast-neutron. *Neutron capture therapy of cancer ... Because fluid models usually describe the plasma in terms of a single flow at a certain temperature at each spatial location, ... Inductively coupled plasmas (ICP), formed typically in argon gas for optical emission spectroscopy or mass spectrometry ... is composed of a single species, is called a non-neutral plasma. In such a plasma, electric fields play a dominant role. ...
... single-photon emission computed tomography (SPECT), near-infrared spectroscopy (NIRS), and event-related optical signal (EROS ... EEG has also been combined with positron emission tomography. This provides the advantage of allowing researchers to see what ... EEG does not involve exposure to radioligands, unlike positron emission tomography.[28] ... and computed tomography (CT). Despite limited spatial resolution, EEG continues to be a valuable tool for research and ...
... blood flow and cerebral hematocrit in patients with cerebral ischemia measured by single-photon emission computed tomography". ... In fact, it was recently shown that, following a single paired-avoidance paradigm in mice, LTP could be recorded in some ... The calcium entry also phosphorylates CaMKII, which phosphorylates AMPARs, increasing their single-channel conductance. ... and increases their single channel conductance.[13] The T840 site was more recently discovered, and has been implicated in LTD. ...
... "computed tomography" could be used to describe positron emission tomography or single photon emission computed tomography ( ... such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT). X-ray tomography, a ... For non-medical computed tomography, see industrial computed tomography scanning. For non-X-ray tomography, see Tomography. ... X-ray computed tomography (X-ray CT), computerized axial tomography scan (CAT scan),[2] computer aided tomography, computed ...
While for a single term, such as the mass term mφ4(φ/mPl)2, the slow roll conditions can be satisfied for φ much greater than m ... The angular power spectrum of polarized dust emission at intermediate and high Galactic latitudes". Astronomy & Astrophysics. ... Hawking and Page later found ambiguous results when they attempted to compute the probability of inflation in the Hartle- ... the radiation energy density goes down even more rapidly as the Universe expands since the wavelength of each photon is ...
In photon therapy, most of the radiation effect is through free radicals. Cells have mechanisms for repairing single-strand DNA ... With Godfrey Hounsfield's invention of computed tomography (CT) in 1971, three-dimensional planning became a possibility and ... in the 1970s and positron emission tomography (PET) in the 1980s, has moved radiation therapy from 3-D conformal to intensity- ... Single-strand DNA damage is then passed on through cell division; damage to the cancer cells' DNA accumulates, causing them to ...
... positron emission tomography, single-photon emission computed tomography, event-related potential, and electroencephalography, ... It has been argued that any individual with DID is a single person with a serious mental illness, and therefore exhibits ... No studies have looked for children with DID in the general population, and the single study that attempted to look for ... First, the change emphasizes the main problem is not a multitude of personalities, but rather a lack of a single, unified ...
The use of single photon emission computed tomography on an elderly patient with Alzheimer's Disease revealed greater blood ... mood and brain blood flow in single photon emission computed tomography following individual reminiscence therapy in an elderly ... single - blind, randomized control study." International Journal of Geriatric Psychiatry. 27: 187 - 196. . ...
Figure 1: The amplitude of a single frequency wave as a function of time t (red) and a copy of the same wave delayed by τ (blue ... To produce coherent light he passed the monochromatic light from an emission line of a mercury-vapor lamp through a pinhole ... In contrast, optical coherence tomography, in its classical version, uses light with a short coherence time. ... the future technologies of quantum computing and the already available technology of quantum cryptography. Additionally the ...
... positron emission tomography (PET), single-photon emission tomography (SPECT). CT scans and MRI are the two techniques widely ... such as computed tomography (CT) scan, magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and magnetic resonance ...
... single-photon emission computed tomography). In the most modern devices Nuclear Medicine images can be fused with a CT scan ... Computed tomography (CT)[cuir in eagar , athraigh foinse]. Príomhalt: X-ray computed tomography ... Positron emission tomography (PET), scanning is a nuclear medicine procedure that deals with positrons. The positrons ... Positron emission tomography, which produces a three-dimensional image. *Radiobiology, the interdisciplinary science that ...
Single photon sources[edit]. See single photon sources. Single photon sources are novel types of light sources distinct from ... This emission of light is only observable whilst the exciation light is still providing photons to the fluorescent molecule and ... "Among optical techniques, an emerging imaging technology based on laser scanning, the optical coherence tomography or OCT ... and detection of photons, quantum units of light. Photonics is related to electronics and photons. Photons play a central role ...
... single-photon emission computed tomography - SPECT or Positron-emission tomography - PET). In the most modern devices, nuclear ... computed tomography (CT), nuclear medicine including positron emission tomography (PET), and magnetic resonance imaging (MRI) ... computed tomography (CT), nuclear medicine including positron emission tomography (PET), and magnetic resonance imaging (MRI). ... Positron emission tomography (PET) scanning deals with positrons instead of gamma rays detected by gamma cameras. The positrons ...
... and with single-photon emission computed tomography (SPECT) or positron emission tomography (PET) can be used to help exclude ... Of the many medical imaging techniques available, single photon emission computed tomography (SPECT) appears to be superior in ... Advanced medical imaging with computed tomography (CT) or magnetic resonance imaging (MRI), ... as a single test, to identify people who may develop Alzheimer's disease is also not supported by evidence.[133] ...
... and single photon emission computed tomography (SPECT).[citation needed] Various radiopharmaceuticals targeted at specific ... Brain perfusion (more correctly transit times) can be estimated with contrast-enhanced computed tomography.[12] ... Cerebral blood flow determination by rapid-sequence computed-tomography: theoretical analysis. Radiology 137: 679-686, December ... a comparison between cardiovascular magnetic resonance imaging and positron emission tomography". J Cardiovasc Magn Reson. 19 ( ...
Single-photon emission computed tomography is a well established functional imaging technique in epilepsy that aids precise ... Single photon emission computed tomography Neuroimaging Clin N Am. 1995 Nov;5(4):647-73. ... Single-photon emission computed tomography is a well established functional imaging technique in epilepsy that aids precise ... Ictal single photon emission computed tomography studies in temporal lobe epilepsy demonstrate transient intense hyperemia in ...
Single-photon emission computed tomography (SPECT, or less commonly, SPET) is a nuclear medicine tomographic imaging technique ... "D. Boulfelfel, R.M. Rangayyan, L.J. Hahn, R. Kloiber, Restoration of Single Photon Emission Computed Tomography Images". ... Luo, S, Zhou, T (2014). "Superiorization of EM algorithm and its application in single-photon emission computed tomography ( ... X-ray computed tomography (X-ray CT), and positron emission tomography (PET). SPECT is similar to PET in its use of radioactive ...
The detector assembly detects photon strikes from the field of view. A photon-blocking member is disposed between the field of ... A collimating assembly includes a plurality of collimating vanes formed of photon-attenuating material. A support assembly ... A single photon emission computed tomography system includes a base for supporting a patient and a detector assembly adjacent ... view and the detector and has an aperture slot that allows passage of photons aligned with the slot. ...
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  • Positron emission tomography studies in temporal lobe epilepsy are moderately sensitive, demonstrating ipsilateral hypometabolism. (nih.gov)
  • This data set may then be manipulated to show thin slices along any chosen axis of the body, similar to those obtained from other tomographic techniques, such as magnetic resonance imaging (MRI), X-ray computed tomography (X-ray CT), and positron emission tomography (PET). (wikipedia.org)
  • In a previous study, in the symptomatic patients, the absence of measurable CAC has a high negative predictive value of obstructive CAD [ 7 ] and may exclude inducible ischemia at functional testing as myocardial perfusion Positron Emission Tomography (PET) in patients at low or intermediate risk for CAD [ 8 ]. (pulsus.com)
  • Thus, when used in combination with positron-emission tomography/single-photon emission computed tomography (PET/SPECT), β-amyloid imaging agents could serve as surrogate markers for the early diagnosis and neuropathogenetic studies of AD. (go.jp)
  • Principles of positron emission tomography. (helsinki.fi)
  • Shelton, David K. / Magnetic resonance imaging, positron emission tomography, and single-photon-emission computed tomography in epilepsy . (elsevier.com)
  • 5,11,12 In a single centre study, perfusion-CMR was superior for detection of CAD in comparison with single-photon emission computed tomography (SPECT), 13 and perfusion-CMR was similar in performance in comparison with positron emission tomography. (mittenmen.org)
  • Practice Parameters and Technical … Positron emission tomography (PET) and single photon emission computed tomogra- phy (SPECT) are two modern imaging techniques with a wide range of medical applica- tions. (mittenmen.org)
  • Other imaging modalities that can be used in the diagnosis of temporal lobe epilepsy include computed tomography (CT) scanning, positron emission tomography (PET) scanning, single-photon emission CT (SPECT) scanning, MR spectroscopy, and magnetoencephalography (MEG). (medscape.com)
  • Positron Emission Tomography makes use of radio isotopes such as gallium-68, when two gamma rays each of 511KeV, are emitted simultaneously where a positron from a nuclear disintegration annihilates in tissue. (seminarsonly.com)
  • Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial i. (nih.gov)
  • Myocardial infarcts are routinely detected by nuclear imaging techniques such as single photon emission computed tomography (SPECT) myocardial perfusion imaging. (nih.gov)
  • The data on the prevalence of myocardial ischemia on Myocardial Perfusion Single Photon Emission Computed Tomography (MPS) in symptomatic patients with zero CACS and low to intermediate risk probability is lacking and controversial. (pulsus.com)
  • We used 99mTc-hexamethylpropyleneamine oxime single-photon emission computed tomography (SPECT) to study cerebral perfusion in patients treated with streptokinase for acute ischemic stroke in an open and prospective study. (ahajournals.org)
  • ASTRO Patient Summary: Objective Versus Subjective Assessment of Single Photon Emission Computed Tomography (SPECT) Cardiac Perfusion Scans to Asse. (oncolink.org)
  • Serial single photon emission computed tomography (SPECT), near-infrared spectroscopy (NIRS), and transcranial doppler (TCD) sonography examinations were performed to investigate changes of cerebral perfusion and tissue oxygenation in a patient with complicated cerebral malaria that have been acquired in Nigeria. (ajtmh.org)
  • Assessment of coronary ischaemia by myocardial perfusion dipyridamole stress technetium-99 m tetrofosmin, single-photon emission computed tomography, and coronary angiography in children with Kawasaki disease: pre- and post-coronary bypass grafting. (biomedsearch.com)
  • Evaluation of myocardial perfusion by single-photon emission computed tomography may identify the haemodynamic significance of coronary lesions. (biomedsearch.com)
  • Of the 21 patients, 16 (groups I and II) patients with myocardial perfusion defects, who underwent coronary bypass grafting, were followed up with single-photon emission computed tomography. (biomedsearch.com)
  • Conclusion: Technetium-99 m tetrofosmin single-photon emission computed tomography can be applied as an accurate non-invasive diagnostic technique for detecting myocardial perfusion defects with coronary artery lesions, and to show improved or even normalised perfusion of the myocardium in patients after surgical revascularisation. (biomedsearch.com)
  • This study assessed the validity of a novel approach to myocardial perfusion scintigraphy that provides the opportunity to avoid the drawbacks of standard same-day rest/stress technetium-99m sestamibi myocardial perfusion studies by using separate-acquisition dual-isotope rest thallium-201 and exercise technetium-99m sestamibi single-photon emisson computed tomography (SPECT). (onlinejacc.org)
  • Objectives This study aimed to evaluate the incidence and clinical outcomes of abnormal ventilation/perfusion (V/Q) single-photon emission computed tomography (SPECT) without thromboembolism, especially in patients with group I pulmonary arterial hypertension (PAH). (onlinejacc.org)
  • The prognostic utility of myocardial perfusion single-photon emission CT (MPS) in patients with varying degrees of renal dysfunction and the impact of CKD on cardiac death prediction in patients undergoing MPS have not been investigated. (ovid.com)
  • BACKGROUND: -Previous studies have shown that the presence of stenosis alone on multislice computed tomography (MSCT) has a limited positive predictive value for the presence of ischemia on myocardial perfusion imaging (MPI). (uzh.ch)
  • Myocardial perfusion gated single-photon emission computed tomography in patients with left bundle branch block: comparison between the end-diastolic images and the ungated images. (inserm.fr)
  • The aim of this study was to compare myocardial perfusion imaging obtained from ungated and diastolic thallium gated single-photon emission computed tomography (SPECT) images in patients with LBBB. (inserm.fr)
  • Objectives: This study evaluated the clinical significance of an isolated transient ischemic dilatation (TID) in the otherwise normal or relatively normal single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in determining the risk of future cardiac events. (wits.ac.za)
  • Evaluation of myocardial perfusion and function by gated single-photon emission computed tomography technetium-99m methoxyisobutylisonitrile in children and adolescents with severe congenital heart disease. (semanticscholar.org)
  • Site of myocardial infarction and severity of perfusion abnormalities impact on post-stress left ventricular function in patients with single-vessel disease: gated single-photon emission computed tomography methoxyisobutylisonitrile study. (semanticscholar.org)
  • Single-photon emission computed tomography (SPECT), used mainly for functional brain and myocardial perfusion imaging, is a nuclear medicine imaging technique. (express-healthcare.co.uk)
  • ASNC SPECT IMAGING GUIDELINES Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition,, In particular, the high spatial resolution of perfusion-CMR allows detection of small, even subendocardial perfusion deficits. (mittenmen.org)
  • Myocardial perfusion imaging (MPI) using combined computed tomography (CT) and single-photon emission CT (SPECT) systems plays an important role in the management of patients with coronary artery disease (CAD). (radcliffecardiology.com)
  • CFR was correlated with contractile reserve assessed by low-dose dobutamine echocardiography and with the total perfusion defect measured by single-photon emission computed tomography 72 hours after reperfusion and at 5 months follow-up. (biomedcentral.com)
  • New iodinated neuroreceptor single photon emission computed tomography imaging agents hold promise in localizing the seizure focus (focally reduced uptake) without ictal injection, and also may elucidate underlying mechanisms inherent to epilepsy. (nih.gov)
  • Single-photon emission computed tomography (SPECT, or less commonly, SPET) is a nuclear medicine tomographic imaging technique using gamma rays. (wikipedia.org)
  • The diagnosis was based on clinical, computed tomographic, and cerebrospinal fluid (CSF) criteria. (bmj.com)
  • An emission tomographic system for imaging an object of interest is described. (google.com)
  • A computed tomography scan employs computer processed arrangements of several X-ray images which have been taken from many different angles in order to produce tomographic or cross sectional virtual slices or images of precise areas of a particular scanned object. (qyresearchreports.com)
  • What is the impact of an internal quality improvement project (QIP) on compliance with appropriate use criteria (AUC) for single-photon emission computed tomographic sestamibi (SPECT) in a single center? (acc.org)
  • SPECT imaging is performed by acquiring multiple images (aka projections) with, Single photon emission computed tomography (SPECT) is a medical imaging technique that is based on conventional nuclear medicine imaging and tomographic reconstruction methods. (mittenmen.org)
  • The slow development of adequate single-photon radiopharmaceuticals has prevented tomographic studies of the brain from becoming routine protocols in the clinical environment. (taylorfrancis.com)
  • With the availability of large-field-of-view rotating cameras that offer routine emission-computed tomography, it seems reasonable to consider the lung as a good candidate for SPECT tomographic imaging. (taylorfrancis.com)
  • THE first commercial Single Photon- ECT or SPECT imaging device was developed by Edward and Kuhl and they produce tomographic images from emission data in 1963. (seminarsonly.com)
  • SPECT is a nuclear imaging scan that integrates computed tomography (CT) and a radioactive tracer. (mayfieldclinic.com)
  • A single-photon emission computed tomography (SPECT) scan is a type of nuclear medicine study that involves intravenous injection of a radioactive pharmaceutical that will concentrate in the desired organ(s) and shows how well the organ is functioning. (rightdiagnosis.com)
  • Single photon emission computed tomography ( SPECT ) is a three-dimensional nuclear medicine imaging technique combining the information gained from scintigraphy with that of computed tomography. (radiopaedia.org)
  • In nuclear emission tomography, gamma cameras or detectors typically are used for locating and displaying human glands and organs and associated abnormalities. (google.com)
  • V/Q SPECT findings were reported using European Association of Nuclear Medicine criteria for pulmonary embolism followed by computed tomography pulmonary angiography screening for positive thromboembolism and further invasive pulmonary angiography for distal thromboembolism. (onlinejacc.org)
  • Computed tomography and its application to nuclear medicine. (helsinki.fi)
  • Single Photon Emission Computed Tomography (SPECT) is a nuclear medicine technique that can be used to image almost any organ system. (mittenmen.org)
  • Single-photon emission computed tomography (SPECT) is a nuclear-medicine imaging technique that has been shown to provide clinically useful images of radionuclide distributions within the body. (arizona.edu)
  • Single Photon Emission Computed Tomography (SPECT) imaging is a sophisticated Nuclear Medicine study. (neurospectofflorida.com)
  • Single Photon Emission Computed Tomography, a nuclear imaging diagnostic tool helps in accurate assessment of blood flow to organs. (medindia.net)
  • Tomography in nuclear medicine did not originate after the introduction of X-ray computerized tomography (CT). (osti.gov)
  • misc{etde_640589, title = {Single photon emission computerized tomography (SPECT)} author = {Ganatra, R D} abstractNote = {Tomography in nuclear medicine did not originate after the introduction of X-ray computerized tomography (CT). (osti.gov)
  • Interest in single-photon emission computed tomography (SPECT) has grown considerably since the 10th Annual Symposium on the Sharing of Computer Programs and Technology in Nuclear Medicine in 1980. (taylorfrancis.com)
  • SINGLE PHOTON Emission Computed Tomography involves the use single gamma ray emitted per nuclear disintegration. (seminarsonly.com)
  • SPECT, the acronym of Single Photon Emission Computed Tomography is a nuclear medicine technique that uses radiopharmaceuticals, a rotating camera and a computer to produce images which allow us to visualize functional information about a patient's specific organ or body system. (seminarsonly.com)
  • This procedure is called computerized axial tomography (CAT) scanning. (ascd.org)
  • single photon emission computed tomography-computerized tomography (SPECT-CT) mainly for the purposes of attenuation correction and anatomical localization 1 . (radiopaedia.org)
  • The purpose of the study was to investigate the usefulness of quantitative salivary single-photon emission computed tomography/computed tomography (SPECT/CT) using Tc-99m pertechnetate in Sjögren's syndrome (SS). (springer.com)
  • Parathyroid scintigraphy using 99m Tc-MIBI single photon emission computed tomography (SPECT)/CT has been proposed as one of the most accurate localization techniques in patients with primary hyperparathyroidism (PHPT). (mittenmen.org)
  • The purpose of this study is to evaluate the added value of single photon emission computed tomography-computed tomography (SPECT-CT) over planar scintigraphy, SPECT and CT alone for characterization of isolated skull lesions in bone scintigraphy (BS) in cancer patients. (mittenmen.org)
  • 7 The attenuation map required for AC-MPI can be acquired using a low-dose CT mode (tube current of 20-30mA).The co-registration of SPECT and the attenuation map need to be verified for every patient, even when a semi-automatic method for detection and correction of SPECT-CT emission-transmission misalignment is used. (radcliffecardiology.com)
  • We have prospectively assessed the usefulness and accuracy of sentinel LN (SLN) biopsy for the detection of LN metastases in patients with PTC on preoperative imaging using single photon emission computed tomography/computed tomography (SPECT/CT) and 99mTc phytate. (bvsalud.org)
  • A single photon emission computed tomography (SPECT) scan is an imaging test that shows how blood flows to tissues and organs. (mayfieldclinic.com)
  • These are the diseases or medical conditions in which the medical test 'Single-photon emission computed tomography scan' may be involved. (rightdiagnosis.com)
  • The study used a scan called Single Photon Emission Computed Tomography (or SPECT) to evaluate heart damage. (oncolink.org)
  • Single-photon emission computed tomography (SPECT) scan showed that radioactivity mainly accumu. (medworm.com)
  • Computed tomography is used in the medical field for the purpose of scanning head, lungs, pulmonary angiogram, cardiac, abdominal and pelvic region, and at times to scan fractures occurring in joints and other ligaments and even dislocation of bones. (qyresearchreports.com)
  • 1 A SPECT scan integrates two technologies to view your body: computed tomography (CT) and a radioactive material (tracer). (mittenmen.org)
  • If you are preparing to have a single photon emission computed tomography scan, read on to learn about what to expect with this scan. (brighthub.com)
  • Computed Tomography (CT) scan is a type of medical examination that uses X-rays and computer processing to create sectional images of the body to provide more efficient results than X-rays. (medindia.net)
  • As its name suggests (single photon emission) gamma rays are the sources of the information rather than X-ray emission in the conventional CT scan. (seminarsonly.com)
  • Rabbits were exposed to cigarette smoke for 4 or 16 weeks and underwent single-photon emission computed tomography/computed tomography scanning using technetium-99m-rhAnnexin V-128. (sigmaaldrich.com)
  • Technetium-99m-rhAnnexin V-128 single-photon emission computed tomography signal was increased after smoke exposure at 4 and 16 weeks, with confirmation of increased apoptosis through terminal deoxynucleotidyl transferase dUTP nick end labeling staining and increased tissue neutral sphingomyelinase activity in the tissue. (sigmaaldrich.com)
  • OBJECTIVES The value of gated single-photon emission computed tomography technetium-99m methoxyisobutylisonitrile (gated SPECT (99m)Tc-MIBI) in children is not yet established probably because gated SPECT (99m)Tc-MIBI has rarely been used in pediatric clinical and research studies. (semanticscholar.org)
  • Technetium-99m Methylene Diphosphonate Single-photon. (mittenmen.org)
  • We aimed to evaluate the accuracy of CE to assess LV remodeling after AMI compared with technetium-99m sestamibi gated single photon emission computed tomography (SPECT).Methods: Accordingly, 36 consecutive patients underwent gated SPECT, CE, and cardiovascular magnetic resonance imaging (CMR) 7 to 10 days after AMI. (ucl.ac.uk)
  • Single-photon emission computed tomography is a well established functional imaging technique in epilepsy that aids precise noninvasive localization of the seizure focus required for surgical intervention in refractory seizures. (nih.gov)
  • NIAID researchers used single-photon emission computed tomography (SPECT) and an CD4-specific imaging probe to assess immune system changes throughout macaques infected with SIV, a simian form of HIV, following initiation and interruption of antiretroviral therapy (ART). (federallabs.org)
  • Single Photon Emission Computed Tomography is a functional imaging technique that creates three-dimensional images of the brain on computer. (epilepsyontario.org)
  • Computed tomography and/or magnetic resonance imaging (MRI) and SPECT using 99m Tc-ethylene cystine dimer were performed in all the patients. (bmj.com)
  • Zhao M, Ning H, Feng M, Li S, Chang J, Qi C. Novel [ 99m TcN] 2+ Labeled EGFR Inhibitors as Potential Radiotracers for Single Photon Emission Computed Tomography (SPECT) Tumor Imaging. (mdpi.com)
  • 2014. "Novel [ 99m TcN] 2+ Labeled EGFR Inhibitors as Potential Radiotracers for Single Photon Emission Computed Tomography (SPECT) Tumor Imaging. (mdpi.com)
  • All patients had undergone brain scanning with SPECT during their evaluation, and almost all had also undergone magnetic resonance imaging (MRI) and standard computed tomography (CT). (thefreelibrary.com)
  • Single-Photon Emission Computed Tomography/Computed Tomography Imaging in a Rabbit Model of Emphysema Reveals Ongoing Apoptosis In Vivo. (sigmaaldrich.com)
  • Previously, single-photon emission computed tomography (SPECT) has not been considered a quantitative imaging modality, but recent advances in reconstruction algorithm development have made SPECT quantitative. (ovid.com)
  • Cone-beam emission CT (CE-SPECT) seems potentially useful for animal investigations, pediatric studies, and for brain imaging. (spie.org)
  • This invention relates generally to single photon emission computed tomography (SPECT) imaging and, more particularly, to scatter correction systems and methods for improving images generated from data collected by a SPECT scanner. (google.com)
  • This is the third in a series of papers using identical methodology to evaluate adherence to AUC for SPECT imaging in a single institution. (acc.org)
  • Martin Freesmeyer et al in recent edition of Radiology have reported an initial experience regarding the feasibility and applicability of quasi-integrated freehand single photon emission computed tomography (SPECT)/ultrasonography (US) fusion imaging in patients with thyroid disease. (blogspot.com)
  • Aims To determine diagnostic accuracy, effective radiation dose, and potential value of computed tomography coronary angiography (CTCA) for hybrid imaging with single-photon emission computed tomography (SPECT) comparing prospective electrocardiogram (ECG)-triggering vs. retrospective ECG-gating. (uzh.ch)
  • In this multicenter study the comparative safety and diagnostic efficacy of single-photon emission computed tomography (SPECT) thallium imaging during adenosine-induced coronary hyperemia was compared with exercise treadmill stress. (onlinejacc.org)
  • Here, we describe a reliable, minimally invasive and rapid in vivo imaging technique, using three-dimensional single photon emission computed tomography (3D SPECT) modus, that allows more accurate quantification, serial measurements and spatial discrimination. (ugent.be)
  • Other types of scans, such as computed tomography (CT) scans or magnetic resonance imaging (MRI) show more details of the organs themselves. (uncmedicalcenter.org)
  • SPECT imaging is performed by acquiring multiple images (aka projections) with In this study, we examined the clinical application and safety of employing the newly developed handheld single photon emission tomography (handheld SPECT) device in combination with CT-guided radioactive marking of pulmonary nodules. (mittenmen.org)
  • SPECT is used to track radionuclide compound distribution in vivo, and can also be paired with anatomical imaging techniques like Computed Tomography (CT) to quantify tracer concentrations in organs of interest. (afred.ca)
  • We use signal detection and estimation and simulation methods to optimize the collimator in SPECT (Single Photon Emission Computed Tomography) medical imaging systems. (stonybrook.edu)
  • Lung computed tomography scans of long-term smoke-exposed rabbits exhibit anatomical similarities to human emphysema, with increased lung volumes compared with controls. (sigmaaldrich.com)
  • These computations are achieved by employing the attenuation information provided by computed tomography (CT) scans and by utilizing custom-made cubic spline interpolation. (nanomedicinelab.com)
  • Computed tomography (CT) scans have now emerged as a non-invasive research tool to assess these airway structural changes," Gupta said. (medindia.net)
  • Most false negative results with adenosine, as well as exercise SPECT studies, occurred in patients with single-vessel disease. (onlinejacc.org)
  • Objective: To evaluate diagnostic accuracy of dipyridamole stress technetium-99 m tetrofosmin, single-photon emission computed tomography as a possible alternative to invasive coronary angiography for detection and follow-up of myocardial ischaemia in patients with Kawasaki disease, and pre- and post-coronary bypass grafting. (biomedsearch.com)
  • Patients and methods: Coronary angiography and single-photon emission computed tomography were performed on 21 patients who were classified into three groups - group I (stenosis), group II (giant aneurysms), and group III (small aneurysms). (biomedsearch.com)
  • Ictal single photon emission computed tomography studies in temporal lobe epilepsy demonstrate transient intense hyperemia in the anterior temporal lobe structures. (nih.gov)
  • Interictal single photon emission computed tomography with ipsilateral hypoperfusion, suffers from reduced sensitivity and accuracy, whereas ictal and, to a lesser extent, peri-ictal and postictal single photon emission computed tomography are highly sensitive and accurate in localizing temporal lobe epilepsy. (nih.gov)
  • So, EL & O'Brien, TJ 2012, Peri-ictal single-photon emission computed tomography: Principles and applications in epilepsy evaluation . (elsevier.com)
  • Single-photon emission computed tomography (SPECT) The Objective To determine the intermodality variability of LVEF measured by echocardiography, gated single-photon emission computed tomography (SPECT), and cardiovascular magnetic resonance (CMR) in patients with left ventricular dysfunction. (mittenmen.org)
  • Single-photon emission computed tomography quantitation of gallium citrate uptake for the differentiation of lymphoma from benign hilar uptake. (harvard.edu)
  • Even-Sapir E, Bar-Shalom R, Israel O, Frenkel A, Iosilevsky G, Haim N, Epelbaum R, Gaitini D, Kolodny GM, Front D. Single-photon emission computed tomography quantitation of gallium citrate uptake for the differentiation of lymphoma from benign hilar uptake. (harvard.edu)
  • An assessment of the impact of government regulations and policies on the global Single Photon Emission Computed Tomography Device market operations is also included to provide a holistic overview of the market's future outlook. (sbwire.com)
  • Evaluating the role of single-photon emission computed tomography in the assessment of neurotologic complaints. (thefreelibrary.com)
  • "Single-Photon Emission Computed Tomography Market: Global Industry Analysis (2012 - 2016) and Opportunity Assessment (2017 - 2027)," is Future Market Insights' recent report which offers insights on the various factors driving the popularity of single-photon emission computed tomography (SPECT) in seven regions across the globe. (pharmiweb.com)
  • This section is primarily designed to provide clients with an objective and detailed comparative assessment of key providers specific to a market segment in the single-photon emission computed tomography supply chain and the potential players for the same. (pharmiweb.com)
  • The current clinical practice of reporting images obtained with single photon emission computed tomography (SPECT) with 99mTc-d,l-hexamethylpropylene amine oxime (99mTc HMPAO) images was examined by having 16 experts evaluate the appearance of SPECT images in patients with probable Alzheimer type dementia (ATD), patients with major depressive episode (DSM-IV), and healthy volunteers. (stir.ac.uk)
  • Although the core of the diagnostic process in dementia rests firmly on clinical and cognitive assessments, a wide range of investigations are available to aid diagnosis.Regional cerebral blood flow (rCBF) single-photon emission computed tomography (SPECT) is an established clinical tool that uses an intravenously injected radiolabelled tracer to map blood flow in the brain. (altmetric.com)
  • This information is typically presented as cross-sectional slices through the patient, but can be freely reformatted or, In this study, we examined the clinical application and safety of employing the newly developed handheld single photon emission tomography (handheld SPECT) device in combination with CT-guided radioactive marking of pulmonary nodules. (mittenmen.org)
  • Single photon-emission computed tomography (SPECT) is a test that uses a special type of camera and a tracer (a radioactive substance in liquid form) to look at organs or bones in the body. (uncmedicalcenter.org)
  • Single-photon emission computed tomography (SPECT) uses short-lived radioactive substances to measure the blood flow in the brain. (brainrecoveryproject.org)
  • Objective: To compare the diagnostic value of striatal 123 I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ( 123 I-FP-CIT) single photon emission computed tomography (SPECT) and 123 I-metaiodobenzylguanidine ( 123 I-MIBG) myocardial scintigraphy in differentiating dementia with Lewy bodies (DLB) from other dementia types. (elsevier.com)
  • We conducted a retrospective study to reexamine the value of single-photon emission computed tomography (SPECT) in the evaluation of patients with neurotologic complaints, and to assess the intra- and inter-radiologist variability of SPECT readings. (thefreelibrary.com)
  • The Single Photon Emission Computed Tomography Device Market report provides a holistic evaluation of the market for the forecast period (2018-2027). (verifiedmarketreports.com)
  • EF was evaluated using two software programs of quantitative gated single-photon emission computed tomography (SPECT) (QGS) and cardioREPO. (deepdyve.com)
  • Global Market report from QY Market Research on Single Photon Emission Computed Tomography Device Market 2018 in-depth complete study of the current state of the Single Photon Emission Computed Tomography Device worldwide. (sbwire.com)
  • Deerfield Beach, FL -- ( SBWIRE ) -- 05/09/2018 -- The QY Group is providing latest report on Single Photon Emission Computed Tomography Device market report offers a rough analysis of the different trends and factors impacting the growth trajectory of the global market. (sbwire.com)
  • ¹²³I]FP-CIT single photon emission computed tomography findings in drug-induced Parkinsonism. (ox.ac.uk)
  • Single-photon emission computed tomography (SPECT) evaluates tissue metabolism by detecting electromagnetic radiation emitted from intravenous tracers. (thefreelibrary.com)
  • Dougall N, Nobili F & Ebmeier KP (2004) Predicting the accuracy of a diagnosis of Alzheimer's disease with Tc-99m HMPAO single photon emission computed tomography, Psychiatry Research: Neuroimaging, 131 (2), pp. 157-168. (stir.ac.uk)
  • Purpose: To determine the diagnostic capability of thallium-201 ( 201 Tl) single-photon emission computed tomography (SPECT) combined with Epstein-Barr virus DNA (EBV-DNA) in CSF for the diagnosis of AIDS-related primary CNS lymphoma (PCNSL). (elsevier.com)
  • hence, most SPECT studies of the liver have been limited to space-occupying diseases where transmission tomography is unable to provide a reliable diagnosis. (taylorfrancis.com)
  • In this report, the Global single photon emission computed tomography spect scanner sales market report 2016 market has been carefully studied with numerous features put into inspection for the market to be brought into clear picture before the readers. (qyresearchreports.com)
  • The study further puts stress on the progress graph of the Global single photon emission computed tomography spect scanner sales market report 2016 market along with suitable data pertaining to certain aspects of the market. (qyresearchreports.com)
  • Analysts have accurately and microscopically analyzed the different aspects of the market and this will further aid in broadcasting and executing accurate figures and statistics on numerous facets relating the Global single photon emission computed tomography spect scanner sales market report 2016 market for the coming years. (qyresearchreports.com)
  • The market research publication also offers readers with an inclusive insight on the regions and the scenario of the Global single photon emission computed tomography spect scanner sales market report 2016 market in those regions. (qyresearchreports.com)
  • The study will also offer an instructive overview of the vendor landscape of the Global single photon emission computed tomography spect scanner sales market report 2016 market with as assimilation of facts such as research activities, developments, product portfolio, company revenue, mergers, procurements, and promotion and growth strategies of the superior players operating in the market. (qyresearchreports.com)
  • Now a new study in the Journal of Alzheimer's Disease shows that single photon emission computed tomography, or SPECT, could distinguish depression from CDs with 86 percent accuracy. (healthmanagement.org)
  • A single photon emission computed tomography system includes a base for supporting a patient and a detector assembly adjacent the field of view. (google.com)
  • The detector assembly detects photon strikes from the field of view. (google.com)
  • A photon-blocking member is disposed between the field of view and the detector and has. (google.com)
  • A photon-blocking member is disposed between the field of view and the detector and has an aperture slot that allows passage of photons aligned with the slot. (google.com)
  • With the use of the single-scatter approximation and an energy-windowed detector, the effects of Compton scatter are incorporated into the model. (arizona.edu)
  • Even in the days of rectilinear scanner, tomography was attempted with multiple detector heads rotating around the patient, but the counts at each plane were never very high to obtain a satisfactory image. (osti.gov)
  • Five patients in their first episode of major depressive disorder (MDD) on a single SSRI underwent [123I]5-I-A85380- SPECT neuroimaging prior to stopping their medication and again 6 weeks following medication cessation. (gla.ac.uk)
  • The Single Photon Emission Computed Tomography Device market report analyzes the market on the basis of its major geographies, market segments, and current market trends. (sbwire.com)
  • The report has information of global Single Photon Emission Computed Tomography Device market that comprises of a large number of reputed organizations, firms, vendors, manufacturer and can deliver an in-detail summary of the overall key players who hold major count in terms of revenue, sales, demand, through their reliable services, products, and post-sale processes. (sbwire.com)
  • The Single Photon Emission Computed Tomography Device market report is a complete study of industry growth drivers, current trends in the market, and restraints. (sbwire.com)
  • It provides global Single Photon Emission Computed Tomography Device market projections for the coming years. (sbwire.com)
  • By value and by device development, the global single-photon emission computed tomography market report provides data on global single-photon emission computed tomography along with capacity utilisation and pricing structure across the different regional markets. (pharmiweb.com)
  • The Single Photon Emission Computed Tomography Device Market is growing at a faster pace with substantial growth rates over the last few years and is estimated that the market will grow significantly in the forecasted period i.e. 2020 to 2027. (verifiedmarketreports.com)
  • The Single Photon Emission Computed Tomography Device Market study provides an outlook on the development of market in terms of revenue throughout the prognosis period. (verifiedmarketreports.com)
  • This report provides an all-inclusive environment of the analysis for the Single Photon Emission Computed Tomography Device Market. (verifiedmarketreports.com)
  • Along with the market overview, which comprises of the market dynamics the chapter includes a Porter's Five Forces analysis which explains the five forces: namely buyers bargaining power, suppliers bargaining power, threat of new entrants, threat of substitutes, and degree of competition in the Single Photon Emission Computed Tomography Device Market. (verifiedmarketreports.com)
  • The report also focuses on the competitive landscape of the Single Photon Emission Computed Tomography Device Market. (verifiedmarketreports.com)
  • The market analysis entails a section solely dedicated for major players in the Single Photon Emission Computed Tomography Device Market wherein our analysts provide an insight to the financial statements of all the major players along with its key developments product benchmarking and SWOT analysis. (verifiedmarketreports.com)
  • Other sources include industry magazines, trade journals, government websites and associations were can also be reviewed for gathering precise data on opportunities for business expansions in Single Photon Emission Computed Tomography Device Market. (verifiedmarketreports.com)
  • Primary research involves telephonic interviewsvarious industry experts on acceptance of appointment for conducting telephonic interviewssending questionnaire through emails (e-mail interactions) and in some cases face-to-face interactions for a more detailed and unbiased review on the Single Photon Emission Computed Tomography Device Market, across various geographies. (verifiedmarketreports.com)
  • A PET scanner detects these emissions "coincident" in time, which provides more radiation event localization information and, thus, higher spatial resolution images than SPECT (which has about 1 cm resolution). (wikipedia.org)
  • Emissions from the radionuclide indicate amounts of blood flow in the capillaries of the imaged regions. (wikipedia.org)
  • The SPECT studies were more frequently abnormal compared with computed tomography but did not correlate with stage of meningitis or outcome. (bmj.com)
  • A dual energy window data acquisition algorithm then determines non-scatter photons in a primary energy window utilizing the scatter fraction. (google.com)
  • The scattered photons are modeled by a scatter operator acting on the original activity distribution within the object where the operator consists of convolution with a given analytic kernel followed by a boundary cut-off operation. (arizona.edu)
  • INTRODUCTION Data on single photon emission computed tomography (SPECT) in tuberculous meningitis are lacking and prompted this study. (bmj.com)
  • METHODS We analyzed patients who underwent elective CAS from 2005 to 2008, and underwent single-photon emission computed tomography (SPECT) and transcranial color-coded real-time sonography before and immediately after CAS. (semanticscholar.org)
  • Their tissue distribution profiles at different time points were determined by single photon emission computed tomography/computed tomography. (dovepress.com)
  • Emission Computed Tomography is a technique where by multi cross sectional images of tissue function can be produced , thus removing the effect of overlying and underlying activity. (seminarsonly.com)
  • Takahashi M, Miyauchi T, Kowada M (1980) Computed tomography of Moyamoya disease: demonstration of occluded arteries and collateral vessels as important diagnostic signs. (springermedizin.de)
  • There are no reports on single photon emission computed tomography (SPECT) studies in the available literature. (bmj.com)
  • This is the third in a series of studies from a single center evaluating the adherence to AUC for SPECT. (acc.org)
  • Predictors of hyperperfusion syndrome before and immediately after carotid artery stenting in single-photon emission computed tomography and transcranial color-coded real-time sonography studies. (semanticscholar.org)
  • Recent studies, however, carried out on small and heterogeneous patient samples, have shown that DIP may be associated with [(123)I]FP-CIT single photon emission computed tomography (SPECT) abnormalities, which are markers of dopamine nigrostriatal terminal defect. (ox.ac.uk)
  • We present the attenuated spline reconstruction technique (aSRT) which provides an innovative algorithm for single photon emission computed tomography (SPECT) image reconstruction. (nanomedicinelab.com)
  • Detailed profiles of providers are also included in the scope of the report to evaluate their long-term and short-term strategies, key offerings and recent developments in the global single-photon emission computed tomography market. (pharmiweb.com)
  • This report is an essential reference for who looks for detailed information on China Single Photon Emission Computed Tomography market. (rnrmarketresearch.com)
  • In addition to the data part, the report also provides overview of Single Photon Emission Computed Tomography market, including classification, application, manufacturing technology, industry chain analysis and latest market dynamics. (rnrmarketresearch.com)
  • The report quantifies the market value and market volume share of various segments of the global single-photon emission computed tomography market across the studied regional markets, thereby performing a comprehensive analysis of the global single-photon emission computed tomography market across all levels. (pharmiweb.com)
  • For forecasting the global single-photon emission computed tomography market, various macroeconomic factors and changing trends have been observed, giving an idea about the future of the market. (pharmiweb.com)
  • In the compilation of the report, the forecasts are conducted in terms of CAGR, while other important criteria such as year-on-year growth and incremental dollar opportunity have also been incorporated presenting the client with crystal clear insights and future opportunities likely to emerge in the global single-photon emission computed tomography market. (pharmiweb.com)
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