Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
Application of principles and practices of engineering science to biomedical research and health care.
Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.
Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)
Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
Artificial organs that are composites of biomaterials and cells. The biomaterial can act as a membrane (container) as in BIOARTIFICIAL LIVER or a scaffold as in bioartificial skin.
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
Submicron-sized fibers with diameters typically between 50 and 500 nanometers. The very small dimension of these fibers can generate a high surface area to volume ratio, which makes them potential candidates for various biomedical and other applications.
Procedures for enhancing and directing tissue repair and renewal processes, such as BONE REGENERATION; NERVE REGENERATION; etc. They involve surgically implanting growth conducive tracks or conduits (TISSUE SCAFFOLDING) at the damaged site to stimulate and control the location of cell repopulation. The tracks or conduits are made from synthetic and/or natural materials and may include support cells and induction factors for CELL GROWTH PROCESSES; or CELL MIGRATION.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.
A network of cross-linked hydrophilic macromolecules used in biomedical applications.
Methods and techniques used to genetically modify cells' biosynthetic product output and develop conditions for growing the cells as BIOREACTORS.
Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Salts and esters of the 10-carbon monocarboxylic acid-decanoic acid.
Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Methods for maintaining or growing CELLS in vitro.
The application of engineering principles and methods to living organisms or biological systems.
A biocompatible polymer used as a surgical suture material.
The process of bone formation. Histogenesis of bone including ossification.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
A continuous protein fiber consisting primarily of FIBROINS. It is synthesized by a variety of INSECTS and ARACHNIDS.
A generic term for all substances having the properties of stretching under tension, high tensile strength, retracting rapidly, and recovering their original dimensions fully. They are generally POLYMERS.
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
Manufacturing technology for making microscopic devices in the micrometer range (typically 1-100 micrometers), such as integrated circuits or MEMS. The process usually involves replication and parallel fabrication of hundreds or millions of identical structures using various thin film deposition techniques and carried out in environmentally-controlled clean rooms.
The maximum compression a material can withstand without failure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p427)
The physiological renewal, repair, or replacement of tissue.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
The formation of cartilage. This process is directed by CHONDROCYTES which continually divide and lay down matrix during development. It is sometimes a precursor to OSTEOGENESIS.
The properties and processes of materials that affect their behavior under force.
Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.
Artificial substitutes for body parts and materials inserted into organisms during experimental studies.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
Polymorphic cells that form cartilage.
The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)
A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.
Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Characteristics or attributes of the outer boundaries of objects, including molecules.
Fibrous proteins secreted by INSECTS and SPIDERS. Generally, the term refers to silkworm fibroin secreted by the silk gland cells of SILKWORMS, Bombyx mori. Spider fibroins are called spidroins or dragline silk fibroins.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
A richly vascularized and innervated connective tissue of mesodermal origin, contained in the central cavity of a tooth and delimited by the dentin, and having formative, nutritive, sensory, and protective functions. (Jablonski, Dictionary of Dentistry, 1992)
Nanometer-scale composite structures composed of organic molecules intimately incorporated with inorganic molecules. (Glossary of Biotechnology and Nanobiotechology Terms, 4th ed)
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
Methods and techniques used to modify or select cells and develop conditions for growing cells for biosynthetic production of molecules (METABOLIC ENGINEERING), for generation of tissue structures and organs in vitro (TISSUE ENGINEERING), or for other BIOENGINEERING research objectives.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Numerical expression indicating the measure of stiffness in a material. It is defined by the ratio of stress in a unit area of substance to the resulting deformation (strain). This allows the behavior of a material under load (such as bone) to be calculated.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.
Synthetic material used for the treatment of burns and other conditions involving large-scale loss of skin. It often consists of an outer (epidermal) layer of silicone and an inner (dermal) layer of collagen and chondroitin 6-sulfate. The dermal layer elicits new growth and vascular invasion and the outer layer is later removed and replaced by a graft.
Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
The quality of surface form or outline of CELLS.
The fibrous CONNECTIVE TISSUE surrounding the TOOTH ROOT, separating it from and attaching it to the alveolar bone (ALVEOLAR PROCESS).
The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
A type of CARTILAGE whose matrix contains large bundles of COLLAGEN TYPE I. Fibrocartilage is typically found in the INTERVERTEBRAL DISK; PUBIC SYMPHYSIS; TIBIAL MENISCI; and articular disks in synovial JOINTS. (From Ross et. al., Histology, 3rd ed., p132,136)
Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)
Cells with high proliferative and self renewal capacities derived from adults.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Adherence of cells to surfaces or to other cells.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.
Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
Operative procedures performed on the SKIN.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
A technique for maintaining or growing TISSUE in vitro, usually by DIFFUSION, perifusion, or PERFUSION. The tissue is cultured directly after removal from the host without being dispersed for cell culture.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
A polyester used for absorbable sutures & surgical mesh, especially in ophthalmic surgery. 2-Hydroxy-propanoic acid polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with 1,4-dioxane-2,5-dione copolymer of molecular weight about 80,000 daltons.
The branch of medicine concerned with the application of NANOTECHNOLOGY to the prevention and treatment of disease. It involves the monitoring, repair, construction, and control of human biological systems at the molecular level, using engineered nanodevices and NANOSTRUCTURES. (From Freitas Jr., Nanomedicine, vol 1, 1999).
A type of CARTILAGE characterized by a homogenous amorphous matrix containing predominately TYPE II COLLAGEN and ground substance. Hyaline cartilage is found in ARTICULAR CARTILAGE; COSTAL CARTILAGE; LARYNGEAL CARTILAGES; and the NASAL SEPTUM.
Microbial, plant, or animal cells which are immobilized by attachment to solid structures, usually a column matrix. A common use of immobilized cells is in biotechnology for the bioconversion of a substrate to a particular product. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The flexible rope-like structure that connects a developing FETUS to the PLACENTA in mammals. The cord contains blood vessels which carry oxygen and nutrients from the mother to the fetus and waste products away from the fetus.
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Prosthesis, usually heart valve, composed of biological material and whose durability depends upon the stability of the material after pretreatment, rather than regeneration by host cell ingrowth. Durability is achieved 1, mechanically by the interposition of a cloth, usually polytetrafluoroethylene, between the host and the graft, and 2, chemically by stabilization of the tissue by intermolecular linking, usually with glutaraldehyde, after removal of antigenic components, or the use of reconstituted and restructured biopolymers.
Mesodermal tissue enclosed in the invaginated portion of the epithelial enamel organ and giving rise to the dentin and pulp.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
The structures surrounding and supporting the tooth. Periodontium includes the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.
The interarticular fibrocartilages of the superior surface of the tibia.
Fibrous bands or cords of CONNECTIVE TISSUE at the ends of SKELETAL MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.
Techniques for enhancing and directing cell growth to repopulate specific parts of the PERIODONTIUM that have been damaged by PERIODONTAL DISEASES; TOOTH DISEASES; or TRAUMA, or to correct TOOTH ABNORMALITIES. Repopulation and repair is achieved by guiding the progenitor cells to reproduce in the desired location by blocking contact with surrounding tissue by use of membranes composed of synthetic or natural material that may include growth inducing factors as well.
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.
Methods of creating machines and devices.
Restoration of integrity to traumatized tissue.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
Cartilage of the EAR AURICLE and the EXTERNAL EAR CANAL.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
The bonelike rigid connective tissue covering the root of a tooth from the cementoenamel junction to the apex and lining the apex of the root canal, also assisting in tooth support by serving as attachment structures for the periodontal ligament. (Jablonski, Dictionary of Dentistry, 1992)
Silicone polymers which consist of silicon atoms substituted with methyl groups and linked by oxygen atoms. They comprise a series of biocompatible materials used as liquids, gels or solids; as film for artificial membranes, gels for implants, and liquids for drug vehicles; and as antifoaming agents.
A group of phosphate minerals that includes ten mineral species and has the general formula X5(YO4)3Z, where X is usually calcium or lead, Y is phosphorus or arsenic, and Z is chlorine, fluorine, or OH-. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
The MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body.
Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
The use of computers for designing and/or manufacturing of anything, including drugs, surgical procedures, orthotics, and prosthetics.
Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Therapies that involve the TRANSPLANTATION of CELLS or TISSUES developed for the purpose of restoring the function of diseased or dysfunctional cells or tissues.
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Any of the 23 plates of fibrocartilage found between the bodies of adjacent VERTEBRAE.
A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES).
Loose connective tissue lying under the DERMIS, which binds SKIN loosely to subjacent tissues. It may contain a pad of ADIPOCYTES, which vary in number according to the area of the body and vary in size according to the nutritional state.
Macroporous hydrogels that are produced at subzero temperatures. Cryogels have pores that are produced by growing ice crystals and have been developed with a tissue-like elasticity that is suitable for cell immunization experiments.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Resistance and recovery from distortion of shape.
The behaviors of materials under force.
A TGF-beta subtype that plays role in regulating epithelial-mesenchymal interaction during embryonic development. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta3 and TGF-beta3 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
Cellular functions, mechanisms, and activities.
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
A field of biological research combining engineering in the formulation, design, and building (synthesis) of novel biological structures, functions, and systems.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
The study of the deformation and flow of matter, usually liquids or fluids, and of the plastic flow of solids. The concept covers consistency, dilatancy, liquefaction, resistance to flow, shearing, thixotrophy, and VISCOSITY.
A continuous cell line of high contact-inhibition established from NIH Swiss mouse embryo cultures. The cells are useful for DNA transfection and transformation studies. (From ATCC [Internet]. Virginia: American Type Culture Collection; c2002 [cited 2002 Sept 26]. Available from
The profession concerned with the teeth, oral cavity, and associated structures, and the diagnosis and treatment of their diseases including prevention and the restoration of defective and missing tissue.
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
The branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures.
A biocompatible, hydrophilic, inert gel that is permeable to tissue fluids. It is used as an embedding medium for microscopy, as a coating for implants and prostheses, for contact lenses, as microspheres in adsorption research, etc.
The differentiation of pre-adipocytes into mature ADIPOCYTES.
The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.
The utilization of an electrical current to measure, analyze, or alter chemicals or chemical reactions in solution, cells, or tissues.
An articulation between the condyle of the mandible and the articular tubercle of the temporal bone.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE.
Compounds based on fumaric acid.
A subclass of iridoid compounds that include a glycoside moiety, usually found at the C-1 position.
Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.
Procedures that stimulate nerve elongation over a period of time. They are used in repairing nerve tissue.
A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Nanometer-sized tubes composed of various substances including carbon (CARBON NANOTUBES), boron nitride, or nickel vanadate.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Procedures used to reconstruct, restore, or improve defective, damaged, or missing structures.
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
Dense fibrous layer formed from mesodermal tissue that surrounds the epithelial enamel organ. The cells eventually migrate to the external surface of the newly formed root dentin and give rise to the cementoblasts that deposit cementum on the developing root, fibroblasts of the developing periodontal ligament, and osteoblasts of the developing alveolar bone.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
The process by which cells convert mechanical stimuli into a chemical response. It can occur in both cells specialized for sensing mechanical cues such as MECHANORECEPTORS, and in parenchymal cells whose primary function is not mechanosensory.
The ability to recognize when information is needed and to locate, evaluate, and use the needed information effectively.
Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.
Endothelial cells that line venous vessels of the UMBILICAL CORD.
Differentiated tissue of the central nervous system composed of NERVE CELLS, fibers, DENDRITES, and specialized supporting cells.
Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.
Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
One of a set of bone-like structures in the mouth used for biting and chewing.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
Relating to the size of solids.
A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.
The fern plant family of the order Polypodiales, class Filicopsida, division Pteridophyta, subkingdom Tracheobionta.
A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from:
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
The study of fluid channels and chambers of tiny dimensions of tens to hundreds of micrometers and volumes of nanoliters or picoliters. This is of interest in biological MICROCIRCULATION and used in MICROCHEMISTRY and INVESTIGATIVE TECHNIQUES.
Devices intended to replace non-functioning organs. They may be temporary or permanent. Since they are intended always to function as the natural organs they are replacing, they should be differentiated from PROSTHESES AND IMPLANTS and specific types of prostheses which, though also replacements for body parts, are frequently cosmetic (EYE, ARTIFICIAL) as well as functional (ARTIFICIAL LIMBS).
Acrylic acids or acrylates which are substituted in the C-2 position with a methyl group.
Devices for simulating the activities of the liver. They often consist of a hybrid between both biological and artificial materials.
Nanometer-sized tubes composed mainly of CARBON. Such nanotubes are used as probes for high-resolution structural and chemical imaging of biomolecules with ATOMIC FORCE MICROSCOPY.
A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.
Organic compounds that contain silicon as an integral part of the molecule.
Cells from adult organisms that have been reprogrammed into a pluripotential state similar to that of EMBRYONIC STEM CELLS.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Chemical reactions effected by light.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.
Chemical reaction in which monomeric components are combined to form POLYMERS (e.g., POLYMETHYLMETHACRYLATE).
Derivatives of caproic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated six carbon aliphatic structure.

Born again bone: tissue engineering for bone repair. (1/3513)

Destruction of bone tissue due to disease and inefficient bone healing after traumatic injury may be addressed by tissue engineering techniques. Growth factor, cytokine protein, and gene therapies will be developed, which, in conjunction with suitable carriers, will regenerate missing bone or help in cases of defective healing.  (+info)

Engineering virtual cardiac tissue. (2/3513)

The kinetics of proteins involved in ion transfer, sequestration and binding in cardiac cells can be modelled to construct a model of the electrical activity of isolated cardiac cells as a system of ordinary differential equations. These cell models may be incorporated into tissue models, which, when combined with histology and anatomy, form virtual tissues. The effects of changes in specific protein expression, or changes in protein kinetics, produced by mutations or pharmacological agents, can be simulated using these tissue models and used to account for the whole organ effects of changes in specific ion-transport protein activity.  (+info)

Cellular integration of thyrocytes and thyroid folliculogenesis: a perspective for thyroid tissue regeneration and engineering. (3/3513)

Thyroid gland is composed of many spheroid structures called thyroid follicles, in which thyrocytes are integrated in their specific structural and functional polarization. In conventional monolayer and floating cultures, the cells cannot reorganize follicle structures with normal polarity. By contrast, in a 3-D collagen gel culture thyrocytes easily and stably reconstruct follicles with physiological polarity. Integration of thyrocyte growth and differentiation appears to result in eventual thyroid folliculogenesis. 3-D collagen gel culture and subacute thyroiditis, a specific thyroid disorder, are the promising models for addressing the mechanism of thyroid folliculogenesis. Because formation of 3-D follicles actively occurs both in this culture system and at the regenerative stage of the disease. The understanding of the mechanistic basis of folliculogenesis is prerequisite for establishment of an artificial thyroid tissue, which would enable a more physiological approach to the treatment of hypothyroidism caused by various diseases and surgical processes than conventional hormone replacement therapy. In this review, we have discussed thyrocyte integration, and thyroid folliculogenesis and tissue regeneration, to further thyroid biology. Also, we briefly discussed a perspective on thyroid tissue regeneration and engineering.  (+info)

Oxygen diffusion and consumption of aortic valve cusps. (4/3513)

To maintain tissue oxygenation, normal aortic valves contain a vascular bed where tissue thickness is greatest. Avascular "living" tissue-engineered heart valves have been proposed, yet little information exists regarding the magnitude of valve tissue metabolic activity or oxygen requirements. We therefore set out to measure the oxygen diffusivity (DO(2)) and oxygen consumption (VO(2)) of seven porcine aortic valve cusps in vitro at 37 degrees C using a chamber with a Clark oxygen sensor. Mean DO(2) and VO(2) were 1.06 x 10(-5) cm(2)/s and 3.05 x 10(-5) x ml O(2). ml tissue(-1) x s(-1), respectively. When modeled as a three-layered structure by using these values and a boundary condition of 100 mmHg at both surfaces, the average aortic cusp predicted a central mean PO(2) of 27 mmHg (range of 0-50 mmHg). The DO(2) value obtained was similar to that found for other vascular structures, but because our studies were carried out in vitro, the VO(2) measurements may be lower than that required by the functioning valves. These values provide an initial understanding of the oxygen supply possible from the cusp surfaces and the oxygen needs of the tissue.  (+info)

Self-assembly and mineralization of peptide-amphiphile nanofibers. (5/3513)

We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite material in which the crystallographic c axes of hydroxyapatite are aligned with the long axes of the fibers. This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone.  (+info)

Contaminants from the transplant contribute to intimal hyperplasia associated with microvascular endothelial cell seeding. (6/3513)

OBJECTIVES: seeding prosthetic grafts with fat-derived microvascular endothelial cells (MVEC) results not only in a non-thrombogenic EC layer, but also in intimal hyperplasia. Here we investigated incidence, composition, progression, and cause of this intimal hyperplasia. DESIGN: EPTFE grafts with MVEC were implanted as carotid interpositions in six dogs with 1 month, and in three dogs with 4, 8 and 12 months follow-up. Grafts seeded without cells, implanted in the contralateral carotid, served as a control. In another three dogs labelled cells were seeded to investigate the contribution of the seeded cells (2-3 weeks). MATERIALS AND METHODS: MVEC were isolated from the falciform ligament. Cells were pressure seeded on ePTFE grafts. Labelling was performed using retroviral gene transduction. The grafts were analysed with immunohistochemical techniques. RESULTS: after 1 month, all patent non-seeded grafts (5/6) showed fibrin and platelet deposition, and all patent seeded grafts (5/6) were covered with a confluent endothelial monolayer on top of a multilayer of myofibroblasts, elastin and collagen. After long term follow-up, all non-seeded grafts were occluded, all patent seeded grafts (4 and 12 months) were covered with an EC-layer with intimal hyperplasia underneath. The thickness of the intima did not progress after 1 month. Transduced cells were found in the endothelial monolayer, hyperplastic intima and luminal part of the prosthesis. CONCLUSIONS: MVEC seeding in dogs results in intimal hyperplasia in all patent grafts, which contains myofibroblasts. Contaminants from the transplant contribute to this intimal hyperplasia.  (+info)

Replacing and renewing: synthetic materials, biomimetics, and tissue engineering in implant dentistry. (7/3513)

Hundreds of thousands of implantations are performed each year in dental clinical practice. Dental implants are a small fraction of the total number of synthetic materials implanted into the human body in all fields of medicine. Basically, these millions of implants going into humans function adequately. But longevity and complications still are significant issues and provide opportunities for the creation of improved devices. This manuscript briefly reviews the history of dental implant devices and the concepts surrounding the word "biocompatibility." It then contrasts the foreign body reaction with normal healing. Finally, the article describes how ideas gleaned from the study of normal wound healing can be applied to improved dental implants. In a concluding section, three scenarios for dental implants twenty years from now are envisioned.  (+info)

Expression of renal cell protein markers is dependent on initial mechanical culture conditions. (8/3513)

The rotating wall vessel is optimized for suspension culture, with laminar flow and adequate nutrient delivery, but minimal shear. However, higher shears may occur in vivo. During rotating wall vessel cultivation of human renal cells, size and density of glass-coated microcarrier beads were changed to modulate initial shear. Renal-specific proteins were assayed after 2 days. Flow cytometry antibody binding analysis of vitamin D receptor demonstrated peak expression at intermediate shears, with 30% reduction outside this range. Activity of cathepsin C showed the inverse pattern, lowest at midshear, with twofold increases at either extreme. Dipeptidyl-peptidase IV had no shear dependence, suggesting that the other results are specific, not universal, changes in membrane trafficking or protein synthesis. On addition of dextran, which changes medium density and viscosity but not shear, vitamin D receptor assay showed no differences from controls. Neither cell cycle, apoptosis/necrosis indexes, nor lactate dehydrogenase release varied between experiments, confirming that the changes are primary, not secondary to cell cycling or membrane damage. This study provides direct evidence that mechanical culture conditions modulate protein expression in suspension culture.  (+info)

TY - JOUR. T1 - Substrates for cardiovascular tissue engineering. AU - Bouten, C. V.C.. AU - Dankers, P. Y.W.. AU - Driessen-Mol, A.. AU - Pedron, S.. AU - Brizard, A. M.A.. AU - Baaijens, F. P.T.. PY - 2011/4/30. Y1 - 2011/4/30. N2 - Cardiovascular tissue engineering aims to find solutions for the suboptimal regeneration of heart valves, arteries and myocardium by creating living tissue replacements outside (in vitro) or inside (in situ) the human body. A combination of cells, biomaterials and environmental cues of tissue development is employed to obtain tissues with targeted structure and functional properties that can survive and develop within the harsh hemodynamic environment of the cardiovascular system. This paper reviews the up-to-date status of cardiovascular tissue engineering with special emphasis on the development and use of biomaterial substrates. Key requirements and properties of these substrates, as well as methods and readout parameters to test their efficacy in the human ...
TY - JOUR. T1 - Hydrostatic pressure in articular cartilage tissue engineering. T2 - From chondrocytes to tissue regeneration. AU - Elder, Benjamin D.. AU - Athanasiou, Kyriacos A.. PY - 2009/3/1. Y1 - 2009/3/1. N2 - Cartilage has a poor intrinsic healing response, and neither the innate healing response nor current clinical treatments can restore its function. Therefore, articular cartilage tissue engineering is a promising approach for the regeneration of damaged tissue. Because cartilage is exposed to mechanical forces during joint loading, many tissue engineering strategies use exogenous stimuli to enhance the biochemical or biomechanical properties of the engineered tissue. Hydrostatic pressure (HP) is emerging as arguably one of the most important mechanical stimuli for cartilage, although no optimal treatment has been established across all culture systems. Therefore, this review evaluates prior studies on articular cartilage involving the use of HP, with a particular emphasis on the ...
TY - JOUR. T1 - Functional tissue engineering : ten more years of progress. AU - Guilak, F.. AU - Baaijens, F.P.T.. PY - 2014. Y1 - 2014. N2 - Functional tissue engineering is a subset of the field of tissue engineering that was proposed by the United States National Committee on Biomechanics over a decade ago in order to place more emphasis on the roles of biomechanics and mechanobiology in tissue repair and regeneration. Over the past decade, there have been tremendous advances in this area, pointing out the critical role that biomechanical factors can play in the engineered repair of virtually all tissue and organ systems. In this special issue of the Journal of Biomechanics, we present a series of articles that address a broad array of the fundamental topics of functional tissue engineering, including: (1) measurement and modeling of the in vivo biomechanical environment and history in native and repair tissues; (2) further understanding of the biomechanical properties of native tissues ...
Engineering technology is that part of the technological field which requires the application of scientific and engineering knowledge and methods, combined with technical skills, for the implementation and extension of existing technologies. Engineering technology education focuses on preparing engineering technologists for positions that involve product development and improvement, system development, management, manufacturing and engineering operational functions. Graduates also enter the technical sales and customer services field, or continue in graduate work in engineering or management. Placement of graduates has been excellent.. The Engineering Technology Program awards Bachelor of Science in Engineering Technology (BSET) degrees for each of the following degree options: Construction Engineering Technology (CET), Electrical and Computer Engineering Technology (ECET), Mechanical Engineering Technology (MET), Medical Informatics Technology (MIT), Surveying Engineering Technology (SET), and ...
A key factor in the tissue engineering approach to tissue repair and regeneration is the use of appropriate cells. Mesenchymal stem cells (MSCs) are derived from bone marrow stroma or connective tissues and they have the potential to differentiate into various mesenchymal cell lines in vitro and in vivo. These cells hold great promise for musculoskeletal tissue engineering. This review is based mainly on the work which has been done in the National University of Singapore on the use of MSCs for engineering cartilage, growth plate, bone and tendon/ligament as well as the clinical trail of autologous chondrocyte implantation. It can help to shape future research on musculosketetal tissue engineering ...
The ability to heal soft tissue injuries and regenerate cartilage is the Holy Grail of musculoskeletal medicine. Articular cartilage repair and regeneration is considered to be largely intractable due to the poor regenerative properties of this tissue. Due to their low self-repair ability, cartilage defects that result from joint injury, aging, or osteoarthritis, are the most often irreversible and are a major cause of joint pain and chronic disability. However, current methods do not perfectly restore hyaline cartilage and may lead to the apparition of fibro- or continue hypertrophic cartilage. The lack of efficient modalities of treatment has prompted research into tissue engineering combining stem cells, scaffold materials and environmental factors. The field of articular cartilage tissue engineering, which aims to repair, regenerate, and/or improve injured or diseased cartilage functionality, has evoked intense interest and holds great potential for improving cartilage therapy. Plasma-rich ...
Biomaterials †Khademhosseini Laboratory. The Journal mainly promotes the novel emerging Biomaterial applications to Medical Sciences like Biomaterials, Tissue Engineering Biomaterials Applications,, Buy Biomaterials for Tissue Engineering Applications from Dymocks online BookStore. Find latest reader reviews and much more at Dymocks. Biomaterials and Tissue Engineering MSc UCL Mechanical Engineering. Application and next steps. Applications. Students are advised Application fee: Biomaterials and scaffolds for tissue engineering OBrien F. Biomaterials and scaffolds for tissue the art of scaffolds for tissue engineering applications.. With advancements in biological and engineering sciences, the definition of an ideal biomaterial has evolved over the past 50 years from a substance that is inert to Enhancing cell penetration and proliferation in chitosan hydrogels for tissue engineering applications Chengdong Jia, Ali Khademhosseinib,c,d, Fariba Dehghania,*. Interdisciplinary research into ...
[email protected] Engineering Technology is a technologically advanced program at the Bachelor of Science level utilizing theoretical concepts and hands-on instruction. Program selection is from the following concentrations: Computer Engineering Technology, Electromechanical Engineering Technology, and Mechanical Engineering Technology.. The Mechanical Engineering Technology concentration requires 67 hours is accredited by ABET, Inc. ( and enables students to obtain the skills necessary for placement in highly competitive jobs in machine design, manufacturing, engineering, field service engineering, technical sales, thermal analysis, product design, utilities operations, air conditioning design, plant operations, and a variety of other professions. Through design projects and laboratory training, students examine how to relate such skills to a variety of fields in mechanical engineering technology including product and machine design, power generation, utilities, and ...
This thesis presents a foundation for developing a business case for companies interested in the reconstructive and cosmetic procedure markets. The focus is on reviewing adipose tissue engineering research and proposing technology opportunities that could be applied to challenging soft tissue reconstruction cases and adjacently applied to cosmetic applications. To establish the foundation for this type of program, this thesis includes an evaluation of the reconstructive and cosmetic procedure markets, current practices in these markets and their constraints, as well as a literature review of research in adipose tissue engineering and its potential clinical applications. Additionally it captures the competitive landscape of major players in the reconstructive market as well as up-and-coming players in the adipose tissue engineering field. Technology development opportunities with associated customer and business value are discussed with a recommendation for the development of a detailed business ...
The cardiovascular tissue engineering laboratory aims to develop tissue engineering and cell-based therapeutic approaches for the treatment of cardiac injury and disease.
Cardiac tissue engineering is an emerging field that may hold great promise for advancing the treatment of heart diseases. Cardiac tissue engineering is in its infancy, and the overall field of tissue engineering, which was formalized in the late 1980s at conferences and workshops sponsored by the National Science Foundation, is still new enough to warrant some description. By broad definition, tissue engineering involves the construction of tissue equivalents through the manipulation and combination of living cells and biomaterials. It is a multidisciplinary field combining diverse aspects of the life sciences, engineering, and clinical medicine. The overall goal of tissue engineering is to develop tissue equivalents for use in the repair, replacement, maintenance, or augmentation of tissues or organs. Although some aspects of cardiac tissue engineering research have been ongoing for generations, albeit without being known as such, directed efforts in the field are only beginning.. The main ...
Bone marrow derived mesenchymal stem cells (bmMSCs) are widely used for the generation of tissue engineering constructs, since they can differentiate into different cell types occurring in bone tissues. Until now their use for the generation of tissue engineering constructs is limited. All cells inside a tissue engineering construct die within a short period of time after implantation of the construct because vascularization and establishment of connections to the recipient circulatory system is a time consuming process. We therefore compared the influences of bmMSC, VEGF and a combination of both on the early processes of vascularization, utilizing the mice skinfold chamber model and intravital fluorescence microscopy.. Tissue engineering constructs based on collagen coated Poly d,l-lactide-co-glycolide (PLGA) scaffolds, were either functionalized by coating with vascular endothelial growth factor (VEGF) or vitalized with bmMSC. PLGA without cells and growth factor was used as the control ...
Our MRes Tissue Engineering for Regenerative Medicine course gives students from biological, engineering and/or medical-related backgrounds the specialist knowledge and research skills to pursue a career in this field. The national average salary for a Director of Orthopedics and Tissue Engineering is $142,392 in United States. There is a $95.00 USD manuscript submission fee for all submissions to Tissue Engineering: Part A; Tissue Engineering: Part B (Reviews); and Tissue Engineering: Part C (Methods). Pittsburgh Tissue Engineering Initiative average salary is $102,300, median salary is $102,300 with a salary range from $102,300 to $102,300. The best-paid 25 percent made $114,930 that year, while the lowest-paid 25 percent made $67,830. 2 Director of Orthopedics and Tissue Engineering Salaries in Bothell provided anonymously by employees. Pittsburgh Tissue Engineering Initiative Salaries trends. ACRO Biomedical was founded in June 2014 and positioned to develop biomaterials for human tissue ...
TY - JOUR. T1 - Electrically Stimulated Adipose Stem Cells on Polypyrrole-Coated Scaffolds for Smooth Muscle Tissue Engineering. AU - Björninen, Miina. AU - Gilmore, Kerry. AU - Pelto, Jani. AU - Seppänen-Kaijansinkko, Riitta. AU - Kellomäki, Minna. AU - Miettinen, Susanna. AU - Wallace, Gordon. AU - Grijpma, Dirk. AU - Haimi, Suvi. N1 - EXT=Pelto, Jani. PY - 2016/11/14. Y1 - 2016/11/14. N2 - We investigated the use of polypyrrole (PPy)-coated polymer scaffolds and electrical stimulation (ES) to differentiate adipose stem cells (ASCs) towards smooth muscle cells (SMCs). Since tissue engineering lacks robust and reusable 3D ES devices we developed a device that can deliver ES in a reliable, repeatable, and cost-efficient way in a 3D environment. Long pulse (1 ms) or short pulse (0.25 ms) biphasic electric current at a frequency of 10 Hz was applied to ASCs to study the effects of ES on ASC viability and differentiation towards SMCs on the PPy-coated scaffolds. PPy-coated scaffolds promoted ...
Theoretical and experimental studies were performed to address the relationships between the microstructure, composition, and mechanical behaviors of articular cartilage and hydrogel-based engineered constructs for functional tissue engineering of articular cartilage. The contributions of the two major components of articular cartilage - negatively charged proteoglycans and bimodular collagen fibrils - to electromechanical properties was described by a triphasic model (Lai, Hou et al, 1991) that is incorporated with conewise linear elasticity constitutive model (Cumier, He et al 1995). The model was solved analytically for the unconfined compression stress relaxation. The fixed charge density of the tissue was successfully quantitatively calculated from stress-relaxation experiments on whole tissue samples. The interaction between collagen and proteoglycans, and the resulting residual stress and curling behaviors of cartilage strips were analyzed with a layeredinhomogeneous, orthotropic, ...
In recent years, significant success has been made in the field of regenerative medicine. Tissue engineering scaffolds have been developed to repair and replace different types of tissues. The overall goal of the current work was to develop scaffolds of native extracellular matrix components for soft tissue regeneration, more specifically, neural tissue engineering. To date, much research has been focused on developing a nerve guidance scaffold for its ability to fill and heal the gap between the damaged nerve ends. Such scaffolds are marked by several intrinsic properties including: (1) a biodegradable scaffold or conduit, consisting of native ECM components, with controlled internal microarchitecture; (2) support cells (such as Schwann cells) embedded in a soft support matrix; and (3) sustained release of bioactive factors. In the current dissertation, we have developed such scaffolds of native biomaterials including hyaluronic acid (HA) and collagen. HA is a nonsulphated, unbranched, ...
TY - JOUR. T1 - Carboxymethyl cellulose - Hydroxyapatite hybrid hydrogel as a composite material for bone tissue engineering applications. AU - Pasqui, Daniela. AU - Torricelli, Paola. AU - De Cagna, Milena. AU - Fini, Milena. AU - Barbucci, Rolando. PY - 2014. Y1 - 2014. N2 - Natural bone is a complex inorganic-organic nanocomposite material, in which hydroxyapatite (HA) nanocrystals and collagen fibrils are well organized into hierarchical architecture over several length scales. In this work, we reported a new hybrid material (CMC-HA) containing HA drown in a carboxymethylcellulose (CMC)-based hydrogel. The strategy for inserting HA nanocrystals within the hydrogel matrix consists of making the freeze-dried hydrogel to swell in a solution containing HA microcrystals. The composite CMC-HA hydrogel has been characterized from a physicochemical and morphological point of view by means of FTIR spectroscopy, rheological measurements, and field emission scanning electron microscopy (FESEM). No ...
Biomaterials for bone tissue engineering applications free online course video tutorial by IISc Bangalore.You can download the course for FREE !
Hydrogels are hydrophilic polymers that have a wide range of biomedical applications including bone tissue engineering. In this study we report preparation and characterization of a thermosensitive hydrogel (Zn-CS/β-GP) containing zinc (Zn), chitosan (CS) and beta-glycerophosphate (β-GP) for bone tissue engineering. The prepared hydrogel exhibited a liquid state at room temperature and turned into a gel at body temperature. The hydrogel was characterized by SEM, EDX, XRD, FT-IR and swelling studies. The hydrogel enhanced antibacterial activity and promoted osteoblast differentiation. Thus, we suggest that the Zn-CS/β-GP hydrogel could have potential impact as an injectable in situ forming scaffold for bone tissue engineering applications. Copyright © 2012 Elsevier B.V. All rights reserved.. ...
In situ tissue engineering has become a promising new technique to restore native tissue structure and function by providing a microenvironment necessary to promote tissue regeneration. A biodegradable synthetic starter matrix (scaffold) is introduced to the body to provide this microenvironment at the place of interest. By initiating an inflammatory response upon implantation, a natural wound healing process can be induced to regenerate new tissue. In time, the scaffold will be replaced by this newly formed tissue, resulting in a native, living tissue with growth potential and the capability of remodeling. Within this project, we particularly focus on using in situ tissue engineering to create living heart valves and arteries, as an alternative to the conventional heart valve and small diameter artery replacement therapies, which are accompanied by considerable decrease of life expectancy and therapy-induced complications.
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Bone is the second most transplanted tissue in the body, with approximately 2.2 million bone graft procedures performed annually worldwide. Currently, autogenous bone is the gold standard for bone grafting due to its ability to achieve functional healing; however, it is limited in supply and results in secondary injury at the donor site. Tissue engineering has emerged as a promising means for the development of new bone graft substitutes in order to overcome the limitations of the current grafts. In this research project, the specific approach for bone tissue engineering involves seeding osteoprogenitor cells within a biomaterial scaffold then culturing this construct in a biodynamic bioreactor. The bioreactor imparts osteoinductive mechanical stimuli on the cells to stimulate the synthesis of an extracellular matrix rich in osteogenic and angiogenic factors that are envisioned to guide bone healing in vivo. Fluid flow, which exerts a hydrodynamic shear stress on adherent cells, has been ...
Blood vessels mimics (BVMs) are tissue-engineered blood vessels used to test vascular devices in an environment that mimics some simple anatomical factors of native blood vessels. It is important to accurately and consistently assess tissue-engineered blood vessels, although there is currently a lack of standardization in Cal Polys Tissue Engineering Lab and in the entirety of the field. The goal of this thesis was to develop and optimize imaging and image quantification techniques for tissue-engineered blood vessels. The first aim of this thesis optimized and compared imaging and assessment techniques for electrospun scaffolds. Images from different SEMs were compared to determine the benefits and drawbacks of each microscope. Several materials were also imaged using these microscopes to characterize polymers at the microscopic scale and to compare the quality of images from different SEMs. The second aim of this thesis validated and implemented a MATLAB-based automatic fiber diameter measurement tool
Journal of Environmental Science and Engineering Technology is a scholarly refereed research journal which covers all aspects of environmental science and engineering technology. It is the best international forum for the advancement and dissemination of research results that support high-level learning, teaching and research in the fields of environmental science & engineering technology. The objectives of the journal are to fortify academic exchanges between researchers and academician to endorse and disseminate advancement of environmental science and technology.Our topics of interest includes Environmental Monitoring, Environmental pollution,Geosciences and environmental physics, Environmental Technologies, Environmental Biology,Ecology, Environmental Biotechnology, Environmental Genomics, Environmental Chemistry, Environmental Engineering, Environmental Management, Biogeochemistry, Legal aspects related to Environment, Environmental related research works, Solid and Hazardous Waste ...
Novel tissue engineering approaches are emerging to meet regenerative medicine demands and challenges towards successful therapies to completely restore the function in damaged or degenerated tissues. Among them, magnetic tissue engineering envisions the development of complex systems in which magnetic elements are exploited as remotely controlled multidimensional tools with potential for diagnostic and therapeutic actions. This chapter provides an overview of the latest developments in the design and assessment of magnetic tissue engineering strategies with particular emphasis on smart magnetic materials and their relevance for tissue regeneration. Special attention will be given to the fabrication of sophisticated systems from the nano to the macro scale, and to the role of magnetic smart materials for providing alternative approaches to address the demanding tissue requirements and meet successful alternative strategies for regenerative medicine. The cellular response to the presence of ...
Automotive Engineering Technology (BS). Electrical/Electronics Engineering Technology (BS). Manufacturing Engineering Technology (BS). Manufacturing Tooling Technology (AAS). Mechanical Engineering Technology (BS). Plastics Engineering Technology(BS). Plastics Technology (AAS). Product Design Engineering Technology (BS). Quality Engineering Technology (BS). Mechanical Engineering Technology (AAS). ...
View Notes - Stem Cells in Tissue Engineering from BIO 4400 at Cornell. Stem Cells in Tissue Engineering 4/16/07 Definition 1: g g gg p Tissue engineering is the emerging discipline of design and
Request for Customization @ Table of contents. Chapter 1. Market Synopsis. 1.1. Market Definition. 1.2. Research Scope & Premise. 1.3. Methodology. 1.4. Market Estimation Technique. Chapter 2. Executive Summary. 2.1. Summary Snapshot, 2019-2027. Chapter 3. Indicative Metrics. Chapter 4. Tissue Engineering Market Segmentation & Impact Analysis. 4.1. Tissue Engineering Market Material Segmentation Analysis. 4.2. Industrial Outlook. 4.2.1. Market indicators analysis. 4.2.2. Market drivers analysis. Rising chronic condition incidences. Rising prevalence of disorders associated with the kidney. Increasing resistance to animal use in medical research. Growing demand for tissue engineering processes and regenerative medicine. 4.2.3. Market restraints analysis. The high cost of treatment with tissue engineering. Lack of tissue engineering awareness. 4.3. Technological Insights. 4.4. ...
TY - JOUR. T1 - Principles of cell mechanics for cartilage tissue engineering. AU - Shieh, Adrian C.. AU - Athanasiou, Kyriacos A.. PY - 2003. Y1 - 2003. N2 - The critical importance of mechanical signals to the health and maintenance of articular cartilage has been well demonstrated. Tissue engineers have taken a cue from normal cartilage physiology and incorporated the use of mechanical stimulation into their attempts to engineer functional cartilage. However, the specific types of mechanical stimulation that are most beneficial, and the mechanisms that allow a chondrocyte to perceive and respond to those forces, have yet to be elucidated. To develop a better understanding of these processes, it is necessary to examine the mechanical behavior of the single chondrocyte. This paper reviews salient topics related to chondrocyte biomechanics and mechanotransduction, and attempts to put this information into a context both appropriate and useful to cartilage tissue engineering. It also describes ...
To date, most in vitro and in vivo studies in the field of cardiovascular tissue research rely on the conventional monolayer (2D) cell cultures. Such 2D culture systems may introduce false positive and/or negative results in the mechanistic studies and translational applications primarily due to the microenvironment of 2D cultures that substantially differ from the in vivo cardiovascular cellular and extracellular matrix (ECM) organizations. Recently, it is found that transition from conventional monolayer cell cultures to 3D culture systems contributes to a closer recapitulation of in vivo features, such as cell heterogeneity, ECM, cell signalling, proliferation, maturation, and response to stimuli. Moreover, recent advances in 3D histotypic and organotypic cultures have escalated the impact and scope in the studies of cardiovascular development, diseases, and therapies. For example, the engineered heart tissue/muscle and cardiovascular spheroids have shown great promises in the in vitro modelling of
Myocardial Infarction leads to end-stage heart failure and it is the major cause of death in many industrialized nations. Tissue engineering approaches for treatment of the infarcted tissue has gained huge attention over the recent years and research in this direction mainly aims for the optimization of a biomaterial scaffold with cell-source for tissue regeneration. In this regard, we fabricated absolutely natural polymeric composite scaffolds, using the blood protein, namely fibrinogen, the denatured collagen glycoprotein gelatin and collagen by electrospinning process. Scaffolds with different weight ratios of fibrinogen:gelatin (Fib:Gel) and Fibrinogen:Collagen (Fib:Coll) was prepared and cross-linking (CL) of the electrospun scaffolds was carried out using glutaraldehyde vapors to improve their mechanical properties. The fiber diameters of the fabricated scaffolds were in the range of 150 ? 300 nm which was close to the size of the native protein fibers in the myocardial extracellular ...
Advances in Materials Science and Engineering is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of materials science and engineering.
Cartilage tissue engineering remains a top priority due to the limited intrinsic capacity of articular cartilage for self-repair. In this study, the tissue engineering potential of a decellularized porcine cartilage scaffold, in which the proteoglycans (PG) had also been removed, was evaluated. To improve cell distribution within the scaffold, a novel cell seeding technique using centrifugation and a cell seeding device designed for this technique was developed. The modified porcine cartilage scaffolds were seeded with chondrocytes using the novel cell seeding technique and left in static culture for up to 21 days. A previously described bioreactor was used to measure the properties of the constructs at 7, 14, and 21 days. The ability of the scaffolds to support cell viability and proliferation and extracellular matrix deposition was evaluated at these time points as well. The novel cell seeding technique was also evaluated at 24 hours. Results indicated that the scaffold was capable of supporting cell
The development of human liver scaffolds retaining their 3-dimensional structure and extra-cellular matrix (ECM) composition is essential for the advancement of liver tissue engineering. We report the design and validation of a new methodology for the rapid and accurate production of human acellular …
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Tissue Engineering Society International Annual Conference, Oct. 24, 2005. First Clinical Use of Tissue Engineered Blood Vessels in the Adult Arterial Circulation. Nicolas L´Heureux, Todd McAllister, Sergio Garrido, Alicia Marini, Hernan Avila, Luis de la Fuente, Ximena Manglano, Robert C Robbins, Gerhardt Konig, Nathalie Dusserre. The historical challenge in the field of Cardiovascular Tissue Engineering has been to produce a conduit with the appropriate mechanical strength (i.e. burst pressure in excess of 1700 mmHg). To achieve the requisite strength, most approaches have relied upon permanent synthetic or xenogeneic scaffolds. These scaffolds, however, may be associated with chronic inflammation, disease transmission, or mechanical degradation that limit their clinical use. In an effort to eliminate the deleterious effects of permanent biomaterials, more recent trends have focused on either resorbable scaffolds or completely biological approaches. Previously we reported a completely ...
We have previously reported on the use of Bay K8644-release strategies in combination with perfusion-compression bioreactor systems for up regulating bone formation in three-dimensional PLLA scaffolds. Here we report on the analysis of Bay activity following its release from our PLLA scaffolds over the culture period imposed in our tissue engineering protocol using UV spectroscopy in combination with whole cell patch clamping techniques. Bay was released continually from scaffolds within the physiological range required for agonist activity (1-10 microM). Patch clamping allowed for the effects of Bay released from scaffolds to be monitored directly with respect to osteoblast electrophysiology. A characteristic shift in the current-voltage (I-V) relationship of L-type VOCC currents was observed in rat osteoblast sarcoma (ROS) cells patched in a solution with Bay released from scaffolds following 14 and 28 days incubation, with statistically significant differences observed in peak currents compared to
Autologous tissue-engineered blood vessels (TEBVs) generated using adult stem cells have shown promising results, but many preclinical evaluations do not test the efficacy of stem cells from patient populations likely to need therapy (i.e., elderly and diabetic humans). Two critical functions of these cells will be (i) secreting factors that induce the migration of host cells into the graft and (ii) differentiating into functional vascular cells themselves. The purpose of this study was to analyze whether adipose-derived mesenchymal stem cells (AD-MSCs) sourced from diabetic and elderly patients have a reduced ability to promote human smooth muscle cell (SMC) migration and differentiation potential toward SMCs, two important processes in stem cell-based tissue engineering of vascular grafts ...
ARTEC - Advanced Regenerative Tissue Engineering Centre. Looking for abbreviations of ARTEC? It is Advanced Regenerative Tissue Engineering Centre. Advanced Regenerative Tissue Engineering Centre listed as ARTEC
Cardiac tissue engineering (CTE) is currently a prime focus of research due to an enormous clinical need. In this work, a novel functional material, Poly(3-hydroxyoctanoate), P(3HO), a medium chain length polyhydroxyalkanoate (PHA), produced using bacterial fermentation, was studied as a new potential material for CTE. Engineered constructs with improved mechanical properties, crucial for supporting the organ during new tissue regeneration, and enhanced surface topography, to allow efficient cell adhesion and proliferation, were fabricated. Our results showed that the mechanical properties of the final patches were close to that of cardiac muscle. Biocompatibility of the P(3HO) neat patches, assessed using Neonatal ventricular rat myocytes (NVRM), showed that the polymer was as good as collagen in terms of cell viability, proliferation and adhesion. Enhanced cell adhesion and proliferation properties were observed when porous and fibrous structures were incorporated to the patches. Also, no ...
CR (n = 10) were removed from the bypass system after surgery. Isolation was performed using different isolation methods: blood samples were taken from the cardiopulmonary bypass and centrifuged at low density. The venous filter screen was cut out and placed into petri dishes for cultivation. The spongelike filter was removed, washed and treated in the same way as the blood samples. After cultivation, cell lines of fibroblasts (FB) and endothelial cells (EC) were obtained for analysis. The cells were seeded on polyurethane patches and analyzed via scanning electron microscopy (SEM), Life/Dead assay and immunohistochemistry.. ...
THESIS 8757 Tissue engineering (or regenerative medicine) is defined as the application of scientific principles to the synthesis of living tissues using bioreactors, cells, scaffolds, growth factors, or a combination (Rose and Oreffo, 2002). One of the principal methods in tissue engineering involves the use of a porous scaffold to support and guide synthesis of a 3D tissue or organ (Sachlos and Czernuszka, 2003). Collagen-Glycosaminoglycan scaffolds have found success in several clinical applications of tissue engineering (Yannas et al., 1989, Chamberlain et al., 1998). ...
Bone and Cartilage Engineering provides a complete overview of recent knowledge in bone and cartilage tissue engineering. It follows a logical approach to the various aspects of extracorporal bone and cartilage tissue engineering. The cooperation between a basic scientist and a clinician made it possible to structure the books content and style according to the interdisciplinary character of the field. The comprehensive nature of the book, including detailed descriptions of laboratory procedures, preclinical approaches, clinical applications, and regulatory issues, will make it an invaluable basis for everyone working in this field. This book will serve as a fundamental tool for basic researchers to establish or refine tissue engineering techniques as well as for clinicians to understand and use this modern therapeutic option. ...
This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid system has potential in mesenchymal stem cell based tissue-engineered cartilage repair strategies. The review discusses the potential of cannabinoids to protect against the degradation of cartilage in inflamed arthritic joints and the influence of cannabinoids on the chondrocyte precursors, mesenchymal stem cells (MSCs). We provide experimental evidence to show that activation of the cannabinoid system enhances the survival, migration and chondrogenic differentiation of MSCs, which are three major tenets behind the success of a cell-based tissue-engineered cartilage repair strategy. These findings highlight the potential for cannabinoids to provide a dual function by acting as anti-inflammatory agents as well as regulators of MSC biology in order to enhance tissue engineering strategies aimed at cartilage repair.
Until now, Tissue Engineering techniques have frequently been shown to be promising in vitro and in vivo in experimental settings, but have widely failed to enter the clinical routine when it comes to large defects or major organ functional replacements [13]. One of the key roles for this insufficient transition into clinical practice has been discussed to be dependent on the lack of sufficient vasculature at the time of transplanting laboratory-grown constructs into relevant and especially into poorly vascularized recipient areas. Large bone defects present a prototype of such difficult to handle clinical replacement problems, as vascularized bone grafts are associated with a significant donor-site morbidity and non-vascularized bone grafts do not heal into problematic sites. The optimal bone graft for any successful reconstruction of a large osseus defect would consist of a custom-designed vascularized bone substitute without creating any donor-site morbidity. Almost all bone tissue ...
The development of a functional tissue-engineered human skeletal muscle model in vitro would provide an excellent platform on which to study the process of myogenesis, various musculoskeletal disease states, and drugs and therapies for muscle toxicity. We developed a protocol to culture human skeletal muscle bundles in a fibrin hydrogel under static conditions capable of exerting active contractions. Additionally, we demonstrated the use of joint miR-133a and miR-696 inhibition for acceleration of muscle differentiation, elevation of active contractile force amplitudes, and increasing Type II myofiber formation in vitro. The global hypothesis that motivated this research was that joint inhibition of miR-133a and miR-696 in isolated primary human skeletal myoblasts would lead to accelerated differentiation of tissue-engineered muscle constructs with higher proportion of Type I myofibers and that are capable of significantly increased active contractile forces when subjected to electrical ...
Bektas, C. K., & Hasirci, V. (2018). Mimicking Corneal Stroma Using Keratocyte Loaded Photopolymerizable Methacrylated Gelatin Hydrogels. Journal of Tissue Engineering and Regenerative Medicine.. ...
Sigma-Aldrich offers abstracts and full-text articles by [Paul W Riem Vis, Carlijn V C Bouten, Joost P G Sluijter, Gerard Pasterkamp, Lex A van Herwerden, Jolanda Kluin].
The US Food and Drug Administration approves a device, seeded with a patient’s own cells, which can help repair damaged knee cartilage—a first for autologous cartilage technology.
Cardiac tissue regeneration is an integrated process involving both cells and supporting matrix. Cardiomyocytes and stem cells are utilized to regenerate cardiac tissue. Hydrogels, because of their tissue-like properties, have been used as supporting matrices to deliver cells into infarcted cardiac muscle. Bioactive and biocompatible hydrogels mimicking biochemical and biomechanical microenvironments in native tissue are needed for successful cardiac tissue regeneration. These hydrogels not only retain cells in the infarcted area, but also provide support for restoring myocardial wall stress and cell survival and functioning. Many hydrogels, including natural polymer hydrogels, synthetic polymer hydrogels, and natural/synthetic hybrid hydrogels are employed for cardiac tissue engineering. In this review, types of hydrogels used for cardiac tissue engineering are briefly introduced. Their advantages and disadvantages are discussed. Furthermore, strategies for cardiac regeneration using hydrogels are
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Macroporous hydroxyapatite scaffolds for bone tissue engineering applications: Physicochemical characterization and assessment of rat bone marrow stromal cells ...
This project will develop and demonstrate a prototype Modular Perfusion Bioreactor (MPB) for tissue engineering applications. While many unique styles of bioreactors have been proposed for various types of stem cell and tissue cultures, there is not a single, easy-to-use device that accommodates the multiple diverse needs of multiple tissue culture types.. In order to take advantage of recent advances in stem cell culture, biomaterials, and tissue engineering techniques, Resodyn Corporation proposes to develop, design, fabricate, and test a multi-functional bioreactor platform system. As a starting point for this multi-functional system, Resodyn Corporation will use its highly scalable (50-1,500ml) and successful (>1x108 cells/ml) hypoxia perfusion bioreactor. The focus of the proposed work will be to design additional culture modules that can be plugged into an advanced platform system developed by Resodyn Corporation. Modules that allow the culture of cellular monolayers, encapsulated cells, ...
Kortsmit J, Driessen NJ, Rutten MC, Baaijens FP. Nondestructive and noninvasive assessment of mechanical properties in heart valve tissue engineering. Tissue Eng Part A. 2009 Apr; 15(4):797-806 ...
TY - JOUR. T1 - Effective decellularisation of human saphenous veins for biocompatible arterial tissue engineering applications. T2 - bench optimisation and feasibility in vivo testing. AU - Sulaiman, Nadiah B. AU - Bond, Andrew R. AU - Bruno, Vito Domenico. AU - Joseph, John. AU - Baz Lopez, Daniel. AU - Johnson, Jason L. AU - Suleiman, M-Saadeh. AU - George, Sarah J. AU - Ascione, Raimondo. PY - 2020/12/22. Y1 - 2020/12/22. KW - Decellularisation. KW - Bioengineering. KW - Tissue Engineering. KW - Vascular Graft. M3 - Article (Academic Journal). JO - Journal of Tissue Engineering. JF - Journal of Tissue Engineering. SN - 2041-7314. ER - ...
Mol, A; Hoerstrup, S P (2004). Heart valve tissue engineering -- where do we stand? International Journal of Cardiology, 95(Suppl 1):S57-S58. ...
Scaffold-based tissue engineering requires for transplanted or host cells a biodegradable matrix, which provides a specific environment for tissue development. Efficiency of tissue regeneration through cell implantation in scaffolds depends mainly on the architecture of the scaffold and on the properties of the biomaterial used for their fabrication. The scaffold architecture is characterized by the pore shape and size, size distribution, pore interconnectivity and throat size. Among the polymers selected for tissue engineering, polyurethanes (PUR) represent a very important group. By varying the molecular weight of polyol and the composition of the hard segments, properties of PUR can be tuned for use in tissue engineering, either for reconstruction of soft tissue or for cartilage and bone regeneration. The objective of this study was to characterize polyurethane porous scaffolds fabricated by the salt-leaching/polymer coagulation method. The effect of solution concentration and salt particles ...
In the industrialized world, cardiovascular disease alone is responsible for almost half of all deaths. Many of the conditions can be treated successfully with surgery, often using transplantation techniques; however, autologous vessels or human-donated organs are in short supply. Tissue engineering aims to create specific, matching grafts by growing cells on appropriate matrices, but there are many steps between the research laboratory and the operating theatre. Neo-tissues must be effective, durable, non-thrombogenic and non-immunogenic. Scaffolds should be bio-compatible, porous (to allow cell/cell communication) and amenable to surgery. In the early days of cardiovascular tissue engineering, autologous or allogenic cells were grown on inert matrices, but patency and thrombogenicity of grafts were disappointing. The current ethos is toward appropriate cell types grown in (most often) a polymeric matrix that degrades at a rate compatible with the cells production of their own extracellular ...
TY - JOUR. T1 - Investigating breast cancer cell behavior using tissue engineering scaffolds. AU - Guiro, Khadidiatou. AU - Patel, Shyam A.. AU - Greco, Steven J.. AU - Rameshwar, Pranela. AU - Arinzeh, Treena L.. N1 - Publisher Copyright: © 2015 Guiro et al. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2015/4/2. Y1 - 2015/4/2. N2 - Despite early detection through the use of mammograms and aggressive intervention, breast cancer (BC) remains a clinical dilemma. BC can resurge after ,10 years of remission. Studies indicate that BC cells (BCCs) with self-renewal and chemoresistance could be involved in dormancy. The majority of studies use in vitro, two-dimensional (2-D) monolayer cultures, which do not recapitulate the in vivo microenvironment. Thus, to determine the effect of three-dimensional (3-D) microenvironment on BCCs, this study fabricated tissue engineering scaffolds made of poly (ε-caprolactone) (PCL) having aligned or random fibers. Random and aligned fibers ...
Electrospun tissue engineering scaffolds are attractive due to their distinctive advantages over other types of scaffolds. As both osteoinductivity and osteoconductivity play crucial roles in bone tissue engineering, scaffolds possessing both properties are desirable. In this investigation, novel bicomponent scaffolds were constructed via dual-source dual-power electrospinning (DSDPES). One scaffold component was emulsion electrospun poly(D ,L -lactic acid) (PDLLA) nanofibers containing recombinant human bone morphogenetic protein (rhBMP-2), and the other scaffold component was electrospun calcium phosphate (Ca-P) particle/poly(lactic-co-glycolic acid) (PLGA) nanocomposite fibers. The mass ratio of rhBMP-2/PDLLA fibers to Ca-P/PLGA fibers in bicomponent scaffolds could be controlled in the DSDPES process by adjusting the number of syringes used to supply solutions for electrospinning. Through process optimization, both types of fibers could be evenly distributed in bicomponent scaffolds. The ...
Patients with critical-size bone defects, as a result of trauma, congenital malformations or tumor resections, generally have limited healing without clinical intervention. The autograft is the current standard of care for repair of these defects due to capacity for osteointegration and immunological compatibility. However, potential limitations, such as donor site morbidity, have motivated the development of alternative autologous approaches for the treatment of these defects. Materials used in tissue engineering, such as scaffolds, growth factors and adult stem cells, can be derived from patient blood and adipose tissue and are potential autologous therapeutic options. This dissertation investigates a prospective procedure to improve craniofacial bone healing using fibrin scaffolds and platelet rich plasma from patient blood, and adipose-derived stem cells from liposuction. The objectives of these studies are to evaluate the effects of fibrin scaffolds and platelet-rich plasma on ...
Biological compatibility of a biological derivation bone tissue engineering scaffold was all sidedly evaluated by biological test of basic and additional evaluation. Results showed that the grades of cell culture with the material were grade Ⅰ. There was no sensitization effect; no irritant reactions were found in test of genotoxicity and test of chronic toxicity, there was no irritant reaction to the material implanted in bone and the hemolytic rate was 0 61%. The results demonstrated that the biological derivation bone tissue engineering scaffold is a satisfactory biomaterial.
Learn how Dr. Sam Pashneh-Tala from the University of Sheffield uses SLA 3D printing to enable the production of tissue-engineered blood vessels.
The histomorphometrical analysis of the total scans permitted an evaluation and comparison of the respective cell distribution in the PRF clots. The total length of each clot was measured and a mean of ± SEM was calculated. The distribution/allocation of each cell type was evaluated in the corresponding total scan of the immunohistochemical staining. The analyses revealed that platelets were the only ones found in each area of the clot up to 87 ± 13% in the S-PRF group and up to 84 ± 16% in the A-PRF group (Figure 5). Furthermore, the results showed that T-lymphocytes (S-PRF: 12 ± 5%, A-PRF: 17 ± 9%), B-lymphocytes (S-PRF: 14 ± 7%, A-PRF: 12 ± 9%), CD34-positive stem cells (S-PRF: 17 ± 6%, A-PRF: 21 ± 11%), and monocytes (S-PRF: 19 ± 9%, A-PRF: 22 ± 8%) were not found beyond a certain point of maximally 30% of the total clot length, as they are distributed in or near the BC generated by the centrifugation process (Figure 5). Statistical analysis revealed no statistically significant ...
The tissue engineering and biomaterials research thrust in the Department of Biomedical Engineering focuses on the development of new materials for applications in medicine and biology as well as on engineering biological tissues from adult stem cells. Specific areas of active research include cardiovascular tissue engineering, biopolymers, nitric oxide releasing materials for improved biocompatibility, tissue-biomaterial interaction, and biomimetic materials.
an engineering for thermodynamics an engineering approach 7th edition yunus THERMODYNAMICS 10TH EDITION PDF Read and download free pdf ebook cengel and Fundamentals of Engineering Thermodynamics (7th Edition).pdf. Fundamentals of Engineering Thermodynamics (7th Edition).pdf. Sign In. Details Main menu. [PDF]Free Engineering Thermodynamics 7th Edition By Cengel download Book Engineering Thermodynamics 7th Edition By Cengel.pdf Thermodynamics An Engineering Approach An Engineering Approach 8th Edition pdf , Free Thermodynamics An Engineering Approach 8th Edition Ebook thermodynamics an engineering approach 7th edition. Thermodynamics An Engineering Approach 7th Edition Free Download Pdf hvac engineering fundamentals: part 1 - hvac engineering fundamentals: part 1 3 durable way. Thermodynamics By Cengel 7th Edition Pdf Free Download Thermodynamics books free download ebooks, Thermodynamics an engineering approach 7th edition pdf ,. [PDF]Free Engineering Thermodynamics 7th Edition By Cengel download ...
The American College of the Middle Easts Diploma degree programs in Industrial Engineering Technology, Computer Engineering Technology, Mechanical Engineering Technology and Electrical Engineering Technology have been accredited by the Engineering Technology Accreditation Commission of ABET, which is the global accreditor of college and university programs in applied and natural science, computing, engineering, and engineering technology.. ABET accreditation assures that programs meet standards to produce graduates ready to enter critical technical fields that are leading the way in innovation and emerging technologies, and anticipating the welfare and safety needs of the public.. This accreditation is considered a key step in ACMs journey to raise the level of applied education in Kuwait by adhering to international quality standards and requirements. Moreover, having such programs accredited by ABET is an indication of the quality of education the students receive which meets international ...
The field of tissue engineering has advanced and evolved to focus on biomimetic strategies to meet the rise in demands of tissue replacements for surgical reconstruction. One of the key strategies focuses on developing growth factor delivery systems, by incorporating growth factors into tissue scaffolds. While growth factors are crucial cell-inducing components, their limitations such as short half-lives and dose related adverse effects remain a challenge. To overcome these challenges, this thesis is focused on the development of a novel biomimetic tissue scaffold concept incorporating cell-mediated activation of growth factors for cartilage regeneration. The latent transforming growth factor-β1 (TGF-β1) was selected as a model latent protein due to its well established effects on cartilage as well as its ubiquity in many other tissue types. The thesis first focused on the development and characterisation of the tissue scaffold. A non-woven fibrous scaffold was fabricated by electrospinning, ...
Bioink is one of the important factors for successive laser-assisted bioprinting. It is a combination of cells encapsulated in a biomaterial or combinations of different biomaterials in a hydrogel form. There are two kinds of bioinks currently used in bioprinting, scaffold-based consisted of a cell and a scaffold such as hydrogels, microcarriers, and decellularized matrix as a cell carrier and scaffold-free wherein no biomaterials were used as a cell carrier, only cell aggregates are printed directly.14. Stem cells are the most commonly used cells in bioprinting due to its versatility. These cells are pluripotent that can give rise to different cell types, has the ability of cell renewal or the ability to divide to make more cells, and fast proliferation making it an unlimited cell source for 3D bioprinting.. Different parameters should be considered in choosing materials for bioprinting. Ideal material should be biocompatible, material biomimicry, and appropriate mechanical and rheological ...
Ver más] Tissue engineering is an emerging field of research which combines the use of cell-seeded biomaterials both in vitro and/or in vivo with the aim of promoting new tissue formation or regeneration. In this context, how cells colonize and interact with the biomaterial is critical in order to get a functional tissue engineering product. Cell-biomaterial interaction is referred to here as the phenomenon involved in adherent cells attachment to the biomaterial surface, and their related cell functions such as growth, differentiation, migration or apoptosis. This process is inherently complex in nature involving many physico-chemical events which take place at different scales ranging from molecular to cell body (organelle) levels. Moreover, it has been demonstrated that the mechanical environment at the cell-biomaterial location may play an important role in the subsequent cell function, which remains to be elucidated. In this paper, the state-of-the-art research in the physics and mechanics ...
Polymeric multilayered capsules (PMCs) have found great applicability in bioencapsulation, an evolving branch of tissue engineering and regenerative medicine. Here, we describe the production of hierarchical PMCs composed by an external multilayered membrane by layer-by-layer assembly of poly(L-lysine), alginate, and chitosan. The core of the PMCs is liquified and encapsulates human adipose stem cells and surface functionalized collagen II-TGF-β3 poly(L-lactic acid) microparticles for cartilage tissue engineering.. ...
Acellular matrix obtained from homologous muscular tissue has been previously used to repair muscular defects. However, the implants, although not rejected, give rise to an intense inflammatory response and are rapidly replaced by fibrous tissue. In this study we examined the possibility that co-culture with autologous satellite cells can improve the efficiency of homologous acellular matrix as skeletal muscle substitute. Satellite cells, isolated from rat dorsal muscle, were cultured in vitro on homologous acellular matrix obtained by detergent-enzymatic treatment of abdominal muscle fragments. Scanning electron microscopy revealed that after 24 h of co-culture satellite cells were attached to the matrix, but still possessed a round shape. After 96 h, seeded cells began to flatten and to differentiate, originating few multinucleated myotubes. Patches of homologous matrix, seeded or not with autologous satellite cells, were implanted in the dorsal muscle of rats. At autopsy, the implants were ...
Injuries to articular cartilage are one of the most challenging issues of musculoskeletal medicine due to the poor intrinsic ability of this tissue for repair. Despite progress in orthopaedic surgery, the lack of efficient modalities of treatment for large chondral defects has prompted research on tissue engineering combining chondrogenic cells, scaffold materials and environmental factors. The aim of this review is to focus on the recent advances made in exploiting the potentials of cell therapy for cartilage engineering. These include: 1) defining the best cell candidates between chondrocytes or multipotent progenitor cells, such as multipotent mesenchymal stromal cells (MSC), in terms of readily available sources for isolation, expansion and repair potential; 2) engineering biocompatible and biodegradable natural or artificial matrix scaffolds as cell carriers, chondrogenic factors releasing factories and supports for defect filling, 3) identifying more specific growth factors and the appropriate
The objective of this article is to systematically present the emerging understanding that 3D porous scaffolds serve not only as structural templates for tissue fabrication but also provide complex signaling cues to cells and facilitate oxygen and therapeutic agent delivery. Strategies in the field of tissue engineering and regenerative medicine often rely on 3D scaffolds to mimic the natural extracellular matrix as structural templates that support cell adhesion, migration, differentiation and proliferation, and provide guidance for neo-tissue formation. In addition to providing a temporary support for tissue fabrication, 3D scaffolds have also been used to study cell signaling that best mimics physiological conditions, thereby expanding our understanding beyond 2D cell cultures. It is now understood that cell responses to 3D scaffolds are distinctively different from 2D surfaces. Recently, 3D scaffolds emerged as a vehicle for improved oxygen transport to seeded cells and also to deliver relevant
Many strategies for tissue engineering of replacement structures, such as heart valves, depend in part on preparing a tissue scaffold from a natural tissue matrix. An essential step in tissue scaffold fabrication is decellularization of the matrix. The objective of any decellularization method is twofold: (1) the preservation of the physical and biochemical properties of the extracellular matrix (ECM), and (2) the removal of all cellular material. Decellularization is currently done by contacting xenographic tissue with a combination of chemical detergents and biological agents. These processes can alter ECM structure and composition, which can trigger host immune response and inflammation. Currently, there are no accepted quantitative standards against which to certify the viability of the decellularized material. However, future standards will certainly include characteristics like removal of nuclear material, biochemical composition, and mechanical strength. We are evaluating a novel ...
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Despite huge efforts, tissue engineers and orthopedic surgeons still face a great challenge to functionally repair osteochondral (OC) defects. Nevertheless, over the past decade great progress has been made to find a suitable strategy towards OC regeneration. In the clinics, some osteochondral tissue engineering (OCTE) approaches have already been applied although with some incongruous outcomes as OC tissue is complex in its architecture and function. In this chapter, we summarize current OCTE strategies that are focused on hierarchical scaffold design, mainly layered scaffolds. Most suitable candidates towards functional regeneration of OC tissues are envisaged from monophasic to the layered scaffolds. Herein is documented a variety of approaches with their intrinsic properties applied as bare scaffolds or in combination with biologics, either in in vitro or in vivo evaluations aiming at functional OC regeneration. The most noteworthy studies in OC regeneration developed within the past 5 years ...
TY - JOUR. T1 - Application of stem cells for articular cartilage regeneration.. AU - Hwang, Nathaniel S.. AU - Elisseeff, Jennifer. PY - 2009/1. Y1 - 2009/1. N2 - Articular cartilage is a highly organized tissue lacking self-regeneration capacity upon lesion. Current surgical intervention by application of in vitro-expanded autologous chondrocytes transplantation procedure is associated with several disadvantages, including donor-site morbidity and inferior fibrocartilage formation at the defect site. However, recent advancements in tissue engineering have provided notable strategies for stem cell-based therapies and articular cartilage tissue engineering. In this review, we discuss the current strategies to engineer cartilage tissues from adult stem cells and human embryonic stem cell-derived cells. The characteristics of adult stem cells, the microenvironmental control of cell fate determination, and the limitation imposed by the intrinsic nature of stem cells are discussed. The strategy to ...
Worldwide, an estimated 2.5 million people live with spinal cord injury, with more than 130,000 new injuries reported each year. Spinal cord injury has a significant impact on patients quality of life, life expectancy and economic burden, with considerable costs associated with primary care and loss of income. Stroke is currently the second leading cause of death in the Western world, ranking after heart diseases and before cancer, and could raise secondary dysfunctions too. In the case of focal brain ischemia and chronic spinal cord injuries, namely whenever an extensive loss of tissue occurs, cell therapy is helpful but not sufficient for the regeneration of the lost tissues. Within these regions, scaffolds are needed in order to provide physical support for axonal regeneration and for the transplanted cells to effectively integrate within the host tissues. To this purpose, tissue engineering, an interdisciplinary field of medical science bringing together the principles of material science, ...
0001]An enormous expenditure of health-care resources was required for the repair and replacement of diseased tissue structures and organs. The most common treatment, replacement with an autograft, produces less than optimal results. However, the supply of autograft, and even allograft, is very limited. Engineering tissues and organs with mammalian cells and a scaffolding material as emerged as a promising alternative approach in the treatment of malfunctioning or lost organs compared to the use of harvested tissues and organs (see Langer, R. S. and J. P. Vacanti, Tissue engineering: the challenges ahead, Scientific American 280(4), 86 (1999)). In this approach, a temporary scaffold is needed to serve as an adhesive substrate for the implanted cells and a physical support to guide the formation of the new organs. Accordingly, the scaffold materials must be custom-engineered to match the biomechanical, biochemical, and biological needs of the specific tissue or organ they are designed to ...
Cardiac patch, which is a suitable alternative to heart transplant, recovers the heart tissue and ensures its sound functioning. The integration of advanced features such as therapeutic control through drug release is another groundbreaking innovation which is expected to be introduced in the cardiac patches and marketed globally in the coming decade. Such improvisations and additional features to the existing cardiac patches is anticipated to fuel the growth of the global cardiac patch market significantly during the 2017-2025 period. However, the limitations of cardiac patches such as the formation of aneurysms and the obstruction of growth potential because of ingrown tissue and calcification leads to multiple replacements and can hamper the market growth.. The global cardiac patch market can be segmented based on end-users and region. In terms of end-users, the market can be divided into hospitals and specialty clinics. The hospitals segment is likely to hold a major share in the global ...
TY - JOUR. T1 - Characterization of chitosan-gelatin scaffolds for dermal tissue engineering. AU - Tseng, Hsiang Jung. AU - Tsou, Tai Li. AU - Wang, Hsian Jenn. AU - Hsu, Shan hui. PY - 2013/1. Y1 - 2013/1. N2 - Porous scaffolds for dermal tissue engineering were fabricated by freeze-drying a mixture of chitosan and gelatin (CG) solutions. Different crosslinking agents including glutaraldehyde, 1-(3-dimethylaminopropyl)-3-ethyl-carbodimide hydrochloride (EDC), and genipin were used to crosslink the scaffolds and improve their biostability. The porous structure and mechanical properties were determined for the scaffolds. The proliferation of human fibroblasts in the scaffolds was analyzed. It was found that EDC crosslinked scaffolds had the greatest amount of cells after four days. EDC crosslinked CG scaffolds had tensile modulus in a dry state and compressive modulus in a wet state similar to commercial collagen wound dressing. They also showed appropriate pore size, high water absorption, and ...
McFetridge, P. S., Abe, K., Horrocks, M. and Chaudhuri, J. B., 2007. Vascular tissue engineering: Bioreactor design considerations for extended culture of primary human vascular smooth muscle cells. Asaio Journal, 53 Sep-Oct (5), pp. 623-630.. ...
Purpose : Upon injury to the cornea, the composition of the extracellular matrix (ECM) rapidly changes to promote wound healing through its interactions with integrins. We hypothesize that ECM remodelling occurring during corneal wound healing causes the activation of very specific signal transduction mediators that favor faster closure of the wound. Our goal is to proceed to the pharmacological inhibition and/or activation of the PI3K/Akt mediators Akt and CREB using the human tissue-engineered cornea (hTECs) as a model. Methods : hTECs produced by the self-assembly approach were wounded with a 8-mm diameter biopsy punch and deposited on another reconstructed human corneal stroma to allow wound closure on a natural ECM. Total RNAs and proteins were prepared from the epithelial cells of wounded and unwounded areas and their gene expression pattern was determined by microarrays. The wounded tissues were then incubated with or without C646 (a CREB inhibitor) or with or without SC79 (an AKT ...
Learn more about stem cells by reading Stem Cell-Based Bone Tissue Engineering with a Hydrogel Scaffold Shows Promise for Bone Repair on the Stemodontics® website.
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Thomas Gaborskis research may be in ultra-thin nano-membranes, but its going to be titanic in advancing tissue engineering.. Gaborski, assistant professor of biomedical engineering at Rochester Institute of Technology, and his research team are developing ways to use ultra-thin nano-membranes and adipose stem cells to create the vascular network necessary in engineering tissue, skin and organs.. For these organs to be viable, there is a need for not only the organ structure but also the inner network of micro-vessels and capillaries. Gaborski is helping develop that complex structure, using transparent and permeable membrane scaffolds to support cell and tissue growth, essential to tissue engineering.. Using adipose-derived stem cells that come from fat tissue, acquired from adults rather than embryos, Gaborski has been able to create functional microenvironments that help support and differentiate stem cells into the specialized cells that make up the human body. Creating engineered tissues ...
This review detailed the most commonly used biomaterial scaffolds for engineering tissues from stem cells by covering the types of materials available and their unique properties. This information allows readers to determine which material best suits their specific application. As mentioned in earlier in this review, many of these materials have not been fully optimized for specific tissue engineering applications and further work will continue to optimize these formulations for translation to the clinic for targeted applications. For example, optimized scaffolds could enhance the survival and differentiation of neural stem cells being transplanted into the diseased or damaged nervous system, which could lead to improved function. The type of material and the cues that are incorporated in the scaffold play a large role in directing the fate of the stem cells seeded inside as detailed in this review. The ability to further functionalize the materials discussed in this review in terms of their ...
QMULs School of Engineering and Materials Science (SEMS) provides outstanding degree programmes coupled with internationally leading research: Study reveals how manipulation of primary cilia may improve cartilage tissue engineering
2002). The tortuosity of scaffolds fabricated using solvent casting is not controllable because it requires the contact of the particulates during the fabrication procedure, which is a random process facilitated by using high humidity. Similarly, poor interconnectivity of pores is reported for scaffolds produced using gas foaming techniques, where only 10%À30% of the scaffolds pores are connected (Hutmacher, 2001). Control of pore size distribution in scaffolds fabricated using freeze-drying is an interesting research topic. 2010. The acellular matrix (ACM) for bladder tissue engineering: a quantitative magnetic resonance imaging study. Magn. Reson. Med. 64 (2), 341À348. 22404. , 2014. One-pot synthesis of macromesoporous bioactive glasses/polylactic acid for bone tissue engineering. Mater. Sci. Eng. C Mater. Biol. Appl. 43, 367À374. 1016/j. 042. Epub 2014 Jul 19. , 2014. Designer functionalised selfassembling peptide nanofibre scaffolds for cartilage tissue engineering. Expert Rev. Mol. ...
TY - JOUR. T1 - Combining back scattered electron microscopy and secondary emission scanning electron microscopy to study articular cartilage morphology without decalcifying and staining the samples. AU - Merolli, A.. AU - Manunta, A.. AU - Phillips, Gary. AU - Santin, Matteo. AU - Catalano, F.. PY - 2010/8/13. Y1 - 2010/8/13. U2 - 10.3969/j.issn.1673-8225.2010.33.001. DO - 10.3969/j.issn.1673-8225.2010.33.001. M3 - Article. VL - 14. SP - 6081. EP - 6086. JO - Journal of Clinical Rehabilitative Tissue Engineering Research. JF - Journal of Clinical Rehabilitative Tissue Engineering Research. SN - 1673-8225. IS - 33. ER - ...
Stem cells have shown huge potential for regenerative medicine, but there are several critical issues to be addressed to further improve therapeutic efficacy and regenerative potential of stem cell therapy and stem cell-based tissue engineering. Functional biomaterials can solve these the limitations of current stem cell therapy by promoting prolieration, specific lineage differentiation and improving in vivo survival and engraftment of transplanted stem cells. This thematic series in Biomaterials Research aims to provide collections of recent studies on developing biomaterials for improving stem cell-based regenerative medicine.. To submit a paper to this series, please visit the Biomaterials Research submission site. Make sure to choose the name of the series under the Are you submitting to a thematic series? question on the Additional information tab.. New articles in the series will appear here as they are published.. ...
If you are looking for admission to B.Tech Civil Engineering course in Rajagiri School of Engineering & Technology, contact the college directly. If you would like to get admission guidance for B.Tech Civil Engineering or other courses in various popular colleges, you may take our admission guidance services. Click the link below to get started with B.Tech Civil Engineering admission in various colleges. ...
Dr. Lee has spearheaded in the development of in vitro tissue models and novel bioreactors in the field of cardiovascular tissue engineering in the past several years. She has developed spontaneously beating heart chambers exhibiting key characteristics of native heart for the first time, which is truly novel and powerful for answering questions that cannot easily be approached in vivo. She has also developed a uniaxial and a biaxial stretching device, which can be used to study the impact of mechanical stimulation on engineered cardiac tissues. More importantly, she has developed a novel flow bioreactor, which allows culture of microvasculature in vitro under the influence of flow, which is critical for any functional tissues. To the best of her knowledge, this was the first gel-based flow bioreactor, which provide a new basis for subsequent co-culture studies with various cell types to develop complex engineered tissue constructs with vascularization capacity, which is extremely critical for ...
A common design constraint in functional tissue engineering is that scaffolds intended for use in load-bearing sites possess similar mechanical properties to the replaced tissue. Here, we tested the hypothesis that in vivo loading would enhance bone morphogenetic protein-2 (BMP-2)-mediated bone regeneration in the presence of a load-bearing PLDL scaffold, whose pores and central core were filled with BMP-2-releasing alginate hydrogel. First, we evaluated the effects of in vivo mechanical loading on bone regeneration in the structural scaffolds. Second, we compared scaffold-mediated bone regeneration, independent of mechanical loading, with alginate hydrogel constructs, without the structural scaffold, that have been shown previously to facilitate in vivo mechanical stimulation of bone formation.. Contrary to our hypothesis, mechanical loading had no effect on bone formation, distribution, or biomechanical properties in structural scaffolds. Independent of loading, the structural scaffolds ...
Background: Cell-based tissue engineering represents a promising management for meniscus repair and regeneration. The present study aimed to investigate whether the injection of parathyroid hormone (PTH) (1-34) could promote the regeneration and chondroprotection of 3D printed scaffold se...
... engineering Biological engineering Biomolecular engineering Biochemical engineering Cell engineering Chemical engineering ECM ... Tissue engineering often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a ... Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and ... Clinical Tissue Engineering Center State of Ohio Initiative for Tissue Engineering (National Center for Regenerative Medicine) ...
... is a specific sub-field of tissue engineering. Neural tissue engineering is primarily a search for ... stem cells and tissue engineering". Journal of Tissue Engineering and Regenerative Medicine. 7 (7): 523-536. doi:10.1002/term. ... known as xenogeneic tissue). While these tissues have an advantage over autologous tissue grafts because the tissue does not ... The need for neural tissue engineering arises from the difficulty of the nerve cells and neural tissues to regenerate on their ...
... is a subset of the general field of tissue engineering, which studies the combined use of cells and ... Engineered skeletal muscle units for repair of volumetric muscle loss in the tibialis anterior muscle of a rat. Tissue ... The major motivation for muscle tissue engineering is to treat a condition called volumetric muscle loss (VML). VML can be ... A major focus of muscle tissue engineering is to create constructs with the functionality of native muscle and ability to ...
The Journal of Tissue Engineering is a peer-reviewed open-access medical journal that covers research on tissue engineering. ... The Journal of Tissue Engineering is abstracted and indexed in: Academic Complete Biological Abstracts CSA Illumina EBSCO ...
Tissue engineered oral mucosa shows promise for clinical use, such as the replacement of soft tissue defects in the oral cavity ... Tissue engineering of oral mucosa combines cells, materials and engineering to produce a three-dimensional reconstruction of ... With the advancement of tissue engineering an alternative approach was developed: the full-thickness engineered oral mucosa. ... Problems, such as tissue shortage and donor site morbidity, do not occur when using full-thickness engineered oral mucosa. The ...
"Three-dimensional scaffolds for tissue engineering applications: role of porosity and pore size". Tissue Engineering Part B: ... The scaffold designed for tissue engineering is one of the most crucial components because it guides tissue construction, ... "Tissue engineering of pulmonary heart valves on allogenic acellular matrix conduits: in vivo restoration of valve tissue". ... "Heart valve tissue engineering: concepts, approaches, progress, and challenges". Annals of Biomedical Engineering. 34 (12): ...
... regenerate or replace damaged human tissue. Tissue engineered medicinal products (TEMPs) vary in terms of the type and origin ... The rapid development in the multidisciplinary field of tissue engineering has resulted in a variety of new and innovative ... Standardization In Cell And Tissue Engineering: Methods And Protocols Woodhead Publishing Series In Biomaterials, Edited By ... 14 January 2011 Reflection Paper On Clinical Aspects Related To Tissue Engineered Products, Committee For Advanced Therapies ( ...
... the Tissue Engineering Society (TES), soon to become the Tissue Engineering Society international (TESi) and the Regenerative ... Tissue Engineering and Regenerative Medicine International Society is an international learned society dedicated to tissue ... tissues or organs to restore or establish normal function. A major technology of regenerative medicine is tissue engineering, ... Tissue engineering emerged during the 1990s as a potentially powerful option for regenerating tissue and research initiatives ...
The Center for Tissue Regeneration and Engineering at Dayton (TREND) is a research center which focuses on tissue regeneration ... Center for Tissue Regeneration and Engineering at Dayton (Articles needing additional references from November 2019, All ...
"Transplantation of a tissue-engineered human vascularized cardiac muscle". Tissue Engineering. Part A. 16 (1): 115-25. doi: ... Human engineered cardiac tissues (hECTs) are derived by experimental manipulation of pluripotent stem cells, such as human ... As tissue engineering technology advances to overcome current limitations, hECTs are a promising avenue for experimental drug ... As a proof of principle, grafts of engineered heart tissues have been implanted in rats following MI with beneficial effects on ...
Nature Biomedical Engineering. 4 (9): 875-888. doi:10.1038/s41551-020-0576-z. PMID 32601394. (Tissue engineering). ... Tissue clearing has also been applied to human cancer tissues Zhao J, Lai HM, Qi Y, He D, Sun H (January 2021). "Current Status ... Tissue clearing refers to a group of chemical techniques used to turn tissues transparent. This allows deep insight into these ... June 2019). "Tissue Clearing and Its Application to Bone and Dental Tissues". Journal of Dental Research. 98 (6): 621-631. doi: ...
2008). "Monitoring Tissue Engineering Using Magnetic Resonance Imaging". Journal of Bioscience and Bioengineering. 106 (6): 515 ... Connective tissue is one of the four primary types of animal tissue, along with epithelial tissue, muscle tissue, and nervous ... Fibroareolar tissue is a mix of fibrous and areolar tissue. Fibromuscular tissue is made up of fibrous tissue and muscular ... Connective tissue can be broadly classified into connective tissue proper, and special connective tissue. Connective tissue ...
v t e (Tissue engineering, All stub articles, Medicine stubs). ... Tissue remodeling occurs in adipose tissue with increased body ... Tissue remodeling is the reorganization or renovation of existing tissues. Tissue remodeling can be either physiological or ... much of the tissue remodeling is pathological, resulting in a large amount of fibrous tissue. By contrast, aerobic exercise can ... or result in the dynamic equilibrium of a tissue such as in bone remodeling. Macrophages repair wounds and remodel tissue by ...
Research dedicated to alternative skin grafts is currently within the purview of tissue engineering. Multiple engineered tissue ... Advanced Tissue Sciences Inc.: learning from the past, a case study for regenerative medicine. Tissue engineering of ... or other tissues. Other biological phenomena such as tissue inflammation can also be considered expansion (see tissue ... The growth of tissue is permanent, but will retract to some degree when the expander is removed. Topically applied tissue ...
The remarkable structural organization and engineering properties makes these tissues desirable candidates for duplication by ... Mineralized tissues are biological tissues that incorporate minerals into soft matrices. Typically these tissues form a ... The mineral is the inorganic component of mineralized tissues. This constituent is what makes the tissues harder and stiffer. ... The degree of mineral in mineralized tissues varies and the organic component occupies a smaller volume as tissue hardness ...
Tissue Engineering. 10 (1-2): 129-37. doi:10.1089/107632704322791772. ISSN 1076-3279. PMID 15009938. (CS1: long volume value, ... on chondrocytes has shown potential as a means to produce therapeutic cellular biomaterials via tissue engineering and ... bone and connective tissues. Overwhelming disorganization of cellular processes involved in the formation of cartilage and bone ... specialized cells that make up fibrous connective tissue, which plays a role in the formation of cellular structure and ...
Techniques such as the EELS-TALC to enhance ACI and MACI with enabling chondrocytes to be tissue engineered with long term ... with the engineered tissue construct containing stem cell progenitors along with those expressing pluripotency markers and with ... Tissue Engineering. 12 (5): 1237-1245. doi:10.1089/ten.2006.12.1237. PMID 16771637. Arumugam, S (2007). "Transplantation of ... This drives efforts to develop ways of using a person's own cells to grow, or re-grow cartilage tissue to replace missing or ...
Tissue Engineering. 13 (10): 2431-40. doi:10.1089/ten.2006.0406. PMC 2835465. PMID 17630878. Tu Q, Valverde P, Chen J (March ... During development, a mouse embryo model with Sp7 expression knocked out had no formation of bone tissue. Through the use of ... Calcified Tissue International. 78 (2): 98-102. doi:10.1007/s00223-005-0146-0. PMID 16467978. S2CID 7621703. Wu L, Wu Y, Lin Y ... a severe phenotype in which there were unaffected chondrocytes and cartilage but absolutely no formation of bone tissue. ...
Tissue engineering; Stem Cells; Known for the Vacanti Mouse Uxbridge has a Board of Selectmen and town meeting government. ... "West Hill Dam, Uxbridge Massachusetts". US Army Corps of Engineers. Archived from the original on October 1, 2007. Retrieved ...
Yates EW, Rupani A, Foley GT, Khan WS, Cartmell S, Anand SJ (2012). "Ligament tissue engineering and its potential role in ... using bone or tissue from another body, either a cadaver or a live donor). Bridge-enhanced ACL repair (using a bio-engineered ... Because the tissue used in an autograft is the patient's own, the risk of rejection is minimal. The retear rate in young, ... Range of motion exercises are used to regain the flexibility of the ligament, prevent or break down scar tissue from forming ...
... a novel tool for tissue engineering". Tissue Engineering Part B: Reviews. 19 (1): 48-57. doi:10.1089/TEN.TEB.2012.0183. ISSN ... She specializes on the potential use of electrical regimes to influence cellular activity for orthopaedic tissue engineering ... Tissue Engineering. 9 (6): 1197-1203. doi:10.1089/10763270360728107. ISSN 1076-3279. PMID 14670107. Wikidata Q40608435. Angela ... towards a smart biomaterial for tissue engineering". Acta Biomaterialia. 10 (6): 2341-53. doi:10.1016/J.ACTBIO.2014.02.015. ...
Biomimetic approach to cardiac tissue engineering: oxygen carriers and channeled scaffolds. Tissue Engineering, 12(8), pp. 2077 ... American Institute for Medical and Biological Engineering as well as Tissue Engineering and Regenerative Medicine Society. ... She also researched on the biometric cues in vitro and developed an engineered oriented cardiac tissue. Radisic has also worked ... She is a Former Chair of the Membership Committee for the Tissue Engineering and Regenerative Medicine International Society. ...
Tissue Engineering. Burlington: Academic Press. pp. 73-87. ISBN 978-0-12-370869-4. Retrieved 2020-11-04. Hesketh R (2012). ... Tissue homeostasis can be defined as the maintenance of a balance between cell division and PCD, resulting in the tissue in ... The first would be for the cells to die faster than they can divide, which would result in tissue atrophy. Alternatively, if ... Lindahl A (2008-01-01). "Chapter 3 - Tissue homeostasis". In van Blitterswijk C, Thomsen P, Lindahl A, Hubbell J (eds.). ...
In 2015, Bhatia was elected a member of the National Academy of Engineering for tissue engineering and tissue regeneration ... Bhatia co-authored the first undergraduate textbook on tissue engineering, Tissue engineering (2004), written for senior-level ... Brown University School of Engineering alumni, MIT School of Engineering faculty, MIT School of Engineering alumni, Harvard ... Bhatia, S. N.; Underhill, G. H.; Zaret, K. S.; Fox, I. J. (July 16, 2014). "Cell and tissue engineering for liver disease". ...
Tissue Engineering. 13 (11): 2681-7. doi:10.1089/ten.2006.0447. PMID 17691866. Chachques JC, Azarine A, Mousseaux E, El Serafi ... which has since advanced into the exciting realms of tissue engineering science. In 2008, Carpentier announced a fully ... The prototype uses electronic sensors and is made from chemically treated animal tissues, called "biomaterials," or a "pseudo- ...
The first animal to synthesise transgenic proteins in their milk were mice, engineered to produce human tissue plasminogen ... Gentner, B.; Naldini, L. (2012-11-01). "Exploiting microRNA regulation for genetic engineering". Tissue Antigens. 80 (5): 393- ... The first field trials of genetically engineered plants occurred in France and the US in 1986, tobacco plants were engineered ... Through tissue culture techniques a single tobacco cell was selected that contained the gene and a new plant grown from it. The ...
... ex vivo engineering of living tissues with adult stem cells". Tissue Engineering. 12 (11): 3007-3019. CiteSeerX ... Yen AH, Sharpe PT (January 2008). "Stem cells and tooth tissue engineering". Cell and Tissue Research. 331 (1): 359-372. doi: ... which can be found in adult tissues, for example, in the muscle, liver, bone marrow and adipose tissue. Mesenchymal stem cells ... Tissue has to be dropped as a way to reach a successful outcome. One may prevent the dangers of surgical interventions using ...
After 20 days of perfusion with growth factors, the engineered heart tissues started to beat again and were responsive to drugs ... Therefore, there is an urgent need for effective cell therapy and lung tissue engineering. Several protocols have been ... Brennan JA, Arrizabalaga JH, Nollert MU (4 April 2018). "Development of a Human Tissue-Engineered Blood Vessel from Adipose- ... Cheng A, Hardingham TE, Kimber SJ (August 2014). "Generating cartilage repair from pluripotent stem cells". Tissue Engineering ...
Tissue Engineering. 11 (5-6): 974-983. doi:10.1089/TEN.2005.11.974. ISSN 1076-3279. PMID 15998236. Wikidata Q40401743. Bhatia, ... diversity and the societal impacts of engineering. Her teaching materials were selected by the National Academy of Engineering ... "Women in Chemical Engineering (WIC) Mentorship Excellence Award". 2012-03-28. Retrieved 2021-05-19. (Articles ... She was elected Fellow of the American Institute of Chemical Engineers, the American Institute for Medical and Biological ...
... tissue engineering, implants and more. Tissue Engineering Substrates Polyethyleneterephthalate (PET) cell adhesion Improved ... Tissue Engineering. Part B, Reviews. 24 (5): 359-372. doi:10.1089/ten.TEB.2018.0056. ISSN 1937-3376. PMC 6199621. PMID 29631491 ...
"CAR T Cells: Engineering Patients' Immune Cells to Treat Their Cancers". National Cancer Institute. 2013-12-06. Retrieved 9 ... tissue or organism) so that the function or the mechanism of the function of that protein may be determined. Phage display is ... Løset GÅ, Berntzen G, Frigstad T, Pollmann S, Gunnarsen KS, Sandlie I (12 January 2015). "Phage Display Engineered T Cell ... Selection Versus Design in Chemical Engineering The ETH-2 human antibody phage library Sidhu SS, Lowman HB, Cunningham BC, ...
Mie theory has been used to determine whether scattered light from tissue corresponds to healthy or cancerous cell nuclei using ... Survikov ST (2011). "Mie Scattering". A-to-Z Guide to Thermodynamics, Heat and Mass Transfer, and Fluids Engineering. ... The Mie solution is also important for understanding the appearance of common materials like milk, biological tissue and latex ... Department of Electrical and Computer Engineering, The University of Michigan, Ann Arbor, Michigan (1972) Kerker, M.; Wang, D.- ...
Wright and Meyerdirk left the university to form Physionic Engineering Inc., which launched the first commercial hand-held ... Fortunately, gestational sac, yolk sac and embryo are surrounded by hyperechoic (brighter) body tissues. Traditional obstetric ... TIS for soft tissues in the first trimester and TIB for bones in second and third trimesters) as low as possible, preferably ... each body tissue type, such as liver, spleen or kidney, has a unique echogenicity. ...
The first commercially practical scuba rebreather was designed and built by the diving engineer Henry Fleuss in 1878, while ... and inject gas into the tissues, along with possible contaminants. Scuba is safety-critical equipment, as some modes of failure ... bomb disposal or engineering operations. In civilian operations, many police forces operate police diving teams to perform " ...
Another risk of these powerful magnets is that if more than one magnet is ingested, they can pinch soft tissues in the ... In: Reed R.P., Fickett F.R., Summers L.T., Stieg M. (eds) Advances in Cryogenic Engineering Materials. An International ... J Biophys Biochem Cytol 4:727-730 Watson ML (1958b) Staining of tissue sections for electron microscopy with heavy metals. J ... the chemical properties of UAc and NdAc would be very similar in binding to tissue in ultrathin sections thus leading to a ...
... engineer for remixes, producer Ben Grosse - remixing Bruce Harris - executive producer Dave Jerden - mix engineer Spit Stix - ... autobiography Scar Tissue as being the most prolific sessions the band ever had. The demo recording was produced by Spit Stix, ...
Other than fat, glucose is stored in most tissues, as an energy resource available within the tissue through glycogenesis which ... October 2003). "Metabolic engineering for microbial production of shikimic acid". Metabolic Engineering. 5 (4): 277-83. doi: ... Koffas M, Roberge C, Lee K, Stephanopoulos G (1999). "Metabolic engineering". Annual Review of Biomedical Engineering. 1: 535- ... Thykaer J, Nielsen J (January 2003). "Metabolic engineering of beta-lactam production". Metabolic Engineering. 5 (1): 56-69. ...
Keratinocytes engineered to not express alpha-catenin have disrupted cell adhesion and activated NF-κB. A tumor cell line with ... Mice lacking plakoglobin have cell adhesion defects in many tissues, although β-catenin substitutes for plakoglobin at many ... Mice engineered to specifically have vascular endothelium cells deficient in β-catenin showed disrupted adhesion between ... F9 cells were genetically engineered to lack β-catenin, resulting in increased association of plakoglobin with E-cadherin. In ...
They include lab-to-pilot-scale fermenter of many capacities, tissue and cell culture facility, facility for maintenance, ... protein design and engineering, fermentation science, microbial physiology and genetics, yeast biology, bioinformatics, ...
... was present in the tissues infected with virus and attempted to isolate and characterize this factor from tissue homogenates. ... Annual Review of Chemical and Biomolecular Engineering. 2: 77-96. doi:10.1146/annurev-chembioeng-061010-114133. PMID 22432611. ... There is no clear evidence to suggest that removing the infected tissue (debridement) followed by interferon drops is an ...
"Stanford Engineering, Abbas El Gamal - Previous Students". Stanford University. Stanford University. 2019. Retrieved 5 Nov 2019 ... "Guardant's blood test tracks microsatellite instability status on par with tissue biopsy in new study". FierceBiotech. Quantex ... 2018) Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- and Plasma-Based ... Dan V. Nicolau; Ramesh Raghavachari; Society of Photo-optical Instrumentation Engineers (2003). "Modeling and simulation of ...
The environment induces damage at various levels, e.g. damage to DNA, and damage to tissues and cells by oxygen radicals ( ... senescence Programmed cell death Regenerative medicine Rejuvenation SAGE KE Stem cell theory of aging Strategies for engineered ... Horvath S (2013). "DNA methylation age of human tissues and cell types". Genome Biology. 14 (10): R115. doi:10.1186/gb-2013-14- ... and vessel wall thickening and reactive tissue formation (atherosclerosis); similar processes in the kidney can lead to kidney ...
Genetic engineering of the paddle region from a species of volcano-dwelling archaebacteria into rat brain potassium channels ... They have a crucial role in excitable cells such as neuronal and muscle tissues, allowing a rapid and co-ordinated ...
March 2022). "The evolution, evolvability and engineering of gene regulatory DNA". Nature. 603 (7901): 455-463. Bibcode: ... June 2009). "Sex steroid receptors in skeletal differentiation and epithelial neoplasia: is tissue-specific intervention ... December 2020). "Automated design of thousands of nonrepetitive parts for engineering stable genetic systems". Nature ...
For engineering controls, CDC and OSHA recommend configuring communal work environments so that workers are spaced at least six ... and offering a face mask to the sick person or asking the sick person to cover their mouth and nose with tissues when coughing ... providing tissues and trash receptacles, preparing for remote work or shift work if needed, discouraging workers from using ... 18-20 Additional engineering controls for these risk groups include isolation rooms for patients with known or suspected COVID- ...
Initially, moving organisms, such as sharks and hagfish, scavenge soft tissue at a rapid rate over a period of months to as ... "Whales as marine ecosystem engineers". Frontiers in Ecology and the Environment. 12 (7): 377-385. doi:10.1890/130220. Archived ... Contaminants that are found in the tissues of marine mammals include heavy metals, such as mercury and lead, but also ... Pfeiffer, Carl J. (1997). "Renal cellular and tissue specializations in the bottlenose dolphin (Tursiops truncatus) and beluga ...
He first shows the device to his older friend Daryl Gutierrez, a tech genius working as an engineer for the GCPD, who is unable ... Using his photokinetic sight to examine a tissue sample from one of the dead metahumans, Signal discovered trace amounts of Nth ... Duke was a child prodigy, going on to compete for a Genius grant against the likes of gifted engineer Daryl Gutierrez (Mr. ... Bloom (Daryl Gutierrez) - Duke's childhood friend and former GCPD engineer turned biokinetic villain. Bloom became obsessed ...
Klose J (1975). "Protein mapping by combined isoelectric focusing and electrophoresis of mouse tissues. A novel approach to ... Annual Review of Biomedical Engineering. 11: 49-79. doi:10.1146/annurev-bioeng-061008-124934. PMID 19400705. Liao L, McClatchy ...
"Inspired by the Tissues of Living Organisms, Researchers Take One Step Closer to Harvesting "Blue Energy"". Yale E360. ... "Kotov wins the Stephanie L. Kwolek Award". Michigan Engineering. May 20, 2016. Retrieved 2021-02-10. "U-M research: New plastic ... "Nicholas A. Kotov , Michigan Engineering". Retrieved 2013-10-08. "". Retrieved 2021-02-10 ... David Turnbull Lectureship Recipients Nanoscale Science and Engineering Forum Award 2020 National Academy of Inventors 2020 ...
"Clinton Revokes Abortion Curbs : Executive orders: President ends ban on fetal tissue research, overturns gag rule at clinics ... providing funding for the Department of Energy and the water resources development activities of the Army Corps of Engineers. ...
Laser capture microdissection use lasers to procure specific cell populations from a tissue section under microscopic ... a surface engineering process applied to mechanical components for reconditioning, repair work or hardfacing Photolithography ... Eye surgery and refractive surgery Soft tissue surgery: CO2, Er:YAG laser Laser scalpel (General surgery, gynecological, ...
A quantitative study of E2F transcriptional dynamics at the single-cell level by using engineered fluorescent reporter cells ... in tumors is much higher than that in normal tissue. Thus there is a net increase in cell number as the number of cells that ...
... tissue model In 1984 development of the US Navy diving computer which was based on a 9 tissue mixed gas model used for the US ... Émile Gagnan, an engineer employed by the Air Liquide company, miniaturized and adapted the regulator manufactured for use with ... The first commercially practical scuba rebreather was designed and built by the diving engineer Henry Fleuss in 1878, while ... The first commercially practical scuba rebreather was designed and built by the diving engineer Henry Fleuss in 1878, while ...
Nature 507:462-470 (2014) Complementing tissue characterisation by integrating transcriptome profiling from the Human Protein ... Fellow of the Australian Academy of Technological Science and Engineering (FTSE) 2016 - Innovate Australia Award for ... Fellows of the Australian Academy of Technological Sciences and Engineering). ...
He began his engineering career as a technology engineer for McDonnell Douglas Astronautics Co., and is now an engineering ... Physiology is the study of life, specifically, how cells, tissues, and organisms function. She is a scientist who did her ... Rafael L. Bras is an engineer and expert in hydrometeorology and global warming. As an engineering hydrologist, his major areas ... Cruz is a senior aerospace engineer in the Exploration Systems Engineering Branch at the NASA Langley Research Center. His ...
CIF Team One was later dispatched by Castle to find Archer as well as retrieve the Cortex, a device containing tissue samples ... The team then breaks into the factory and discovers that the Federation reverse-engineered ODIN into their own orbital ...
Preserved soft tissue was found in the femur of the 70 million year old specimen. Protein sequencing of the material showed it ... The reservoir is managed by the U.S. Army Corps of Engineers, and water levels in the lake are not part of the refuge's ... Constructed in 2004 and opened in 2005, the Center is a partnership between the U.S. Army Corps of Engineers and the U.S. Fish ... As of 2010, the Army Corps of Engineers continues to have primary management authority for a portion of the refuge, with the ...
He explains that cloning and genetic engineering were used to create a breed of elite assassins, with Marty's tissue samples ... The Killer - A genetically engineered clone of Marty that is named Alfie. He was created by mistake. Has been trained in many ...
His scientific field covers aesthetic surgery for face and body, breast reconstruction, tissue engineering, facial muscles ...
... work in biotechnology includes genetic engineering as well as cell culture and tissue culture technologies. Students in this ... Both biomedicine and engineering are Project Lead the Way programs. The engineering program is based on the Project Lead the ... After completing Middleton's Engineering Magnet Pathway, students are well-prepared for the rigors of engineering courses at ... which means students can earn college credit for their engineering classes at PLTW engineering universities, such as Purdue and ...
Biomaterials and Tissue Engineering. Our biomaterials research focuses on the design and synthesis of hydrogels for tissue ... Structure and Properties and Mineralized Tissues on a Nanoscale. We study the structural and mechanical property relationships ... Our 3D bioprinting research is focused on the fabrication of complex multitypic tissue constructs with functional vascular ... We are particularly interested in the hierarchical organization of collagen in mineralized tissues and the specific mineral- ...
... Neural Regen Res. 2018 Aug;13(8):1327-1331. doi ... This engineered microtissue emulates the dense cord-like bundles of astrocytic somata and processes that are the hallmark ... As such, our living microtissue-engineered rostral migratory stream can serve as an in vitro test bed for unlocking the secrets ... In this paper, we summarize the development of fabrication methods for this microtissue-engineered rostral migratory stream and ...
Selection from Developments in Tissue Engineered and Regenerative Medicine Products [Book] ... Preface Tissue engineering and regenerative medicine are two terms often used synonymously. Both describe a field focused on ... Developments in Tissue Engineered and Regenerative Medicine Products by Get full access to Developments in Tissue Engineered ... A subtle difference between these terms may be that tissue engineering emphasizes the biomaterials and engineering components, ...
... and group the areas pertinent to tissue-engineered medic ... This classification will be used by the Tissue-Engineered ... 1.1 This classification outlines the aspects of tissue-engineered medical products that will be developed as standards. This ... The development of products from the new tissue engineering technologies necessitates creation and implementation of new ... and group the areas pertinent to tissue-engineered medical products. ...
Prof. Mustafa presented a keynote lecture at the 28th annual EAO Congress titled Are stem cells the implants of the future
Moreover, our findings showed that porous composite scaffolds could be engineered with initial properties that reproduce the ... The rapid restoration of tissue biomechanical function remains an important challenge, emphasizing the need to replicate ... Tissue engineering seeks to repair or regenerate tissues through combinations of implanted cells, biomaterial scaffolds and ... as the basis for novel composite scaffolds that are consolidated with a chondrocyte-hydrogel mixture into cartilage tissue ...
Biofabusa 2018 Winter Summit: Accelerating the Commercialization of Engineered Tissues. Jan 12, 2018. ... BioFab USA held its 2018 Winter Summit on Accelerating the Commercialization of Engineered Tissues in Manchester, NH, from ... Despite all of the work still to be done, there have been many advances in engineering, which in turn, have had a positive ... Sales Policy Sitemap © 2022 The American Society of Mechanical Engineers. All rights reserved. ...
Honing Cell and Tissue Culture Conditions for Bone and Cartilage Tissue Engineering. Johnny Lam, Esther J. Lee, Elisa C. Clark ... Tissue Engineering and Regenerative Medicine. Book Series: A Cold Spring Harbor Perspectives in Medicine Collection. Subject ... Craniofacial Tissue Engineering. Weibo Zhang and Pamela Crotty Yelick. The Heart and Great Vessels. Ekene Onwuka, Nakesha King ... Tissue Engineering for Art, Design, and Other Cultural Artifacts. Oron Catts and Ionat Zurr. Index. ...
... tissue engineering and oral microbiome. A multidisciplinary team of scientists, clinicians and educationalists undertaking ... Regenerative medicine, tissue engineering and oral microbiome. Regenerating oral tissues and investigating how microbes ... tissue culture, tissue engineering models, advanced imaging, metagenomics and physiological analysis to undertake cutting edge ... Home / Research and expertise / Peninsula Dental School Research Groups / Regenerative medicine, tissue engineering and oral ...
Dental Stem Cells and Bone Tissue Engineering (CELSORDINO) (CELSORDINO). The safety and scientific validity of this study is ... This project aims to develop a new pre-vascularized tissue engineered bone construct, using human cells of a simple and non ... The main limitation in bone regeneration is the lack of vascularization of the newly shaped tissue. The main objective of this ... We will isolate mesenchymal stem cells from dental tissue of wisdom teeth, extracted from patients aged between 13 and 17 years ...
The potential application of tissue engineering for treating human hair loss is obvious and exciting. By analogy, cell therapy ... but tissue engineering or what is sometimes called cell therapy. This technique does not involve the insertion of particular ...
All the latest science news about tissue engineering from ... News tagged with tissue engineering. Tissue engineering. Tissue engineering was once categorised as a subfield of Biomaterials ... While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated ... The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative ...
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IEEE Transactions on Biomedical Engineering contains basic and applied papers dealing with biomedical engineering. Papers range ... IEEE Transactions on Biomedical Engineering (TBME) IEEE Transactions on Biomedical Engineering (TBME) // ... Tissues are classified by HSI of hemodynamic biomarkers. The multimodal device is capable of monitoring oxygen saturation from ... from engineering development in methods and techniques with biomedical applications to experimental and clinical investigations ...
She joined Imperial in 2004 after a Postdoctoral training in the field of tissue engineering with Professor Robert Langer in ... One cell thick monolayers are the simplest tissues found in multicellular organisms, yet they fulfil critical roles in normal ... highly multidisciplinary but revolve around the development of nanostructured bioactive porous scaffolds for tissue engineering ... During our every day life, many of our tissues are subjected to large deformations. ...
A 3D Bioprinted Pseudo-Bone Drug Delivery Scaffold for Bone Tissue Engineering by Pariksha Jolene Kondiah ... Bujoli, B.; Scimeca, J.; Verron, E. Fibrin As A Multipurpose Physiological Platform For Bone Tissue Engineering And Targeted ... 3D bioprinting is currently the most explored field of research in mechanical microenvironment tissue-engineered systems [1]. ... Previous studies conducted in 3D printing and bone tissue engineering have employed polymers of similar nature, designed to ...
Irving Tissue is hiring a Process Engineer Learn about this opportunity and apply! ... Irving Tissue produces both branded and private label bathroom tissue, facial tissue, paper towels, and napkins. Consumers know ... Process Engineer At Irving Tissue, we recognize that the key to our success is our people. We are a family-owned and operated ... Participates in the development of operations team members and junior engineers What We Offer Irving Tissue is proud to offer a ...
A new finding could hasten development of lab-grown blood vessels and other tissues to replace and regenerate damaged tissues ... They placed some of the curcumin-coated nanoparticles in a tube behind pieces of fresh pig tissue and used a magnet to ... A finding by UC Riverside bioengineers could hasten development of lab-grown blood vessels and other tissues to replace and ... Huinan Liu, a bioengineering professor in UC Riversides Marlan and Rosemary Bourns College of Engineering, led a project to ...
... Add to your list(s) Send you e-mail reminders Further detail ... is aimed at facilitating discussion between clinicians and basic scientists in the field of musculoskeletal tissue engineering. ...
Cell-Cell Interaction and Matrix Production Directing Tissue Fabrication. Timothey Ganey, Ph.D., Co.don Tissue Engineering, Inc ... 4:00 Cell-scaffold Based Tissue Engineering for Cartilage. Anthony Ratcliffe, Ph.D., Vice President, Research, Advanced Tissue ... 2:30 Cartilage Tissue Engineering and the Role of Mechanical Forces. Alan J. Grodzinsky, Director, MIT Center for Biomedical ... 11:50 Optimizing Tissue Engineering for Cartilage Barbara D. Boyan, Professor and Director of Orthopedic Research, University ...
Textile Engineering Department, College of Engineering, Sudan University of Science and Technology, Khartoum North, Sudan. ...
The global tissue engineering market size reached US$ 15.9 Billion in 2022 and is expected to reach US$ 33.5 Billion by 2028, ... Tissue Engineering Market Trends: Tissue engineering procedures have proven effective in treating irreversible damage to ... Figure 6: Global: Tissue Engineering Market: Breakup by End User (in %), 2022. Figure 7: Global: Tissue Engineering Market: ... Figure 1: Global: Tissue Engineering Market: Major Drivers and Challenges. Figure 2: Global: Tissue Engineering Market: Sales ...
Personer med emneord «tissue engineering» Navn. Telefon. E-post. Emneord. Sukul, Mousumi Avdelingsingeniør +47 22852355 mousumi ...
Tissue Engineering: New Ears, Grown From Collagen Cells & Tested On Rats, Could Help Wounded Veterans (PHOTOS). ... "People have been working on this for 20 years," said Cathryn Sundback, director of the tissue engineering lab at the hospital, ... In this Monday, July 2, 2012 photo Cathryn Sundback, director of the tissue engineering lab at Massachusetts General Hospital, ... Scientists at the Laboratory for Tissue Engineering and Organ Fabrication there, working to develop reconstructive plastic ...
2017). The case for applying tissue engineering methodologies to instruct human organoid morphogenesis. Acta Biomaterialia, 54: ... The Case for Applying Tissue Engineering Methodologies to Instruct Human Organoid Morphogenesis. Marti-Figueroa CR, Ashton RS ... The case for applying tissue engineering methodologies to instruct human organoid morphogenesis.. Ashton, PhD, R. The Case for ... 2017). The case for applying tissue engineering methodologies to instruct human organoid morphogenesis. Acta Biomaterialia, 54: ...
Biomaterials can be used in tissue engineering and regenerative medicine as scaffolds to assist the natural healing processes. ... Tissue Engineering and Advanced Therapies. Biomaterials can be used in tissue engineering and regenerative medicine as ...
... the nature of human heart tissue by adding linear patterns to the gels to align heart cells and engineer cardiac tissues. "To ... A new - and heart-warming - biomaterial for tissue engineering?. May 7, 2013 ... for tissue engineering applications - not too difficult to make, elastic enough to respond to the dynamic nature of the human ... the team recently reported their success using the MeTro hydrogels to successfully engineer cardiac tissue. ...
... achieving a successful scaffold-free cartilage engineering without chondrogenic stimulus (low cost). ... The scaffold-free tissue engineering using spheroids is pointed out as an approach for optimizing the delivery system of ... "Tissue engineering by self-assembly of cells printed into topologically defined structures," Tissue Engineering Part A, vol. 14 ... The scaffold-free tissue engineering using spheroids is pointed out as an approach for optimizing the delivery system of ...
This file covers exercises and problems along with reading and announcements.
A new finding could hasten development of lab-grown blood vessels and other tissues to replace and regenerate damaged tissues ... They placed some of the curcumin-coated nanoparticles in a tube behind pieces of fresh pig tissue and used a magnet to ... A finding by UC Riverside bioengineers could hasten development of lab-grown blood vessels and other tissues to replace and ... Huinan Liu, a bioengineering professor in UC Riversides Marlan and Rosemary Bourns College of Engineering, led a project to ...
  • Our biomaterials research focuses on the design and synthesis of hydrogels for tissue engineering, growth factor and drug delivery, and the interaction of biomaterials with matrix molecules on the nanoscale. (
  • Both describe a field focused on discovering and developing new ways to help the body's innate ability to restore organ and tissue function using a combination of cells, biomaterials and engineering. (
  • A subtle difference between these terms may be that tissue engineering emphasizes the biomaterials and engineering components, while regenerative medicine accentuates the cellular contribution. (
  • Tissue engineering was once categorised as a subfield of Biomaterials, but having grown in scope and importance it can be considered as a field in its own right. (
  • Biomaterials can be used in tissue engineering and regenerative medicine as scaffolds to assist the natural healing processes. (
  • Tissue engineering has offered wide technologies for developing functional biomaterials substitutes for repair and regeneration of damaged tissue and organs. (
  • The working group will integrate and coordinate research, education and innovation activities in the field of tissue engineering, which combine biomaterials with cells for developing tissues and organs to regenerate tissues and organs undergoing failure caused by disease or by trauma. (
  • The field of tissue engineering requires close interaction of a broad range of disciplines spanning for biomaterials science and engineering to biology and medicine. (
  • The awardee will develop and optimize a pre-vascularized cardiac tissue construct containing hyaluronic acid (HA)-based biomaterials and hESC-derived cardiomyocytes using 3D bioprinting techniques developed in his laboratory. (
  • Following that, we will discuss existing tissue engineering approaches that utilize CAMs and biomaterials to control nerve regeneration. (
  • The project will address the development of healthy tissue and mitigate the risk of infection in implantable devices as new biomaterials are being developed to replace failed, damaged, or defective body parts. (
  • Our 3D bioprinting research is focused on the fabrication of complex multitypic tissue constructs with functional vascular networks for regenerative applications. (
  • Get full access to Developments in Tissue Engineered and Regenerative Medicine Products and 60K+ other titles, with free 10-day trial of O'Reilly. (
  • Tissue engineering and regenerative medicine are two terms often used synonymously. (
  • Get Developments in Tissue Engineered and Regenerative Medicine Products now with the O'Reilly learning platform. (
  • The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells to produce tissues. (
  • Molly Stevens is currently Professor of Biomedical Materials and Regenerative Medicine and the Research Director for Biomedical Material Sciences in the Institute of Biomedical Engineering. (
  • Research in regenerative medicine within her group includes the directed differentiation of stem cells, the design of novel bioactive scaffolds and new approaches towards tissue regeneration. (
  • Huinan Liu , a bioengineering professor in UC Riverside's Marlan and Rosemary Bourns College of Engineering, led a project to investigate curcumin's regenerative properties by coating magnetic iron oxide nanoparticles with the compound and mixing them into a biocompatible hydrogel. (
  • Our results show that bone marrow is an excellent source of adult stem cells containing smooth muscle and endothelial cells, and that these stem cells can be used in regenerative medicine for cardiovascular applications," said Stelios T. Andreadis, Ph.D., associate professor in the UB Department of Chemical and Biological Engineering in the School of Engineering and Applied Sciences. (
  • Journal of Tissue Engineering and Regenerative Medicine , 10 (10), 804-824. (
  • Functional Tissue Engineering for Regenerative Medicine, Human Stem Cell Research, and Study of Disease " is the topic of the UW Department of Bioengineering's annual Robert F. Rushmer Lecture , Friday, March 22, 4:30 p.m. in the William H. Foege Auditorium , (Room S060). (
  • Her research focuses on engineering human tissues for regenerative medicine, stem-cell research and disease study. (
  • This dissertation describes the engineering of an implantable microtissue designed to maintain the regenerative capacity and ultimately improve functional recovery following severe peripheral nerve injury. (
  • Pursuant to the first aim of this dissertation, stretch-grown tissue engineered nerve grafts (TENG) are evaluated as a novel approach for simultaneously facilitating axon regeneration and preserving the regenerative capacity in two clinically relevant porcine models of peripheral nerve injury. (
  • Pursuant to the second aim of this dissertation, development and characterization of a miniaturized tissue engineered nerve graft (micro-TENG) designed to be a more translatable alternative for preserving the regenerative capacity via minimally invasive injection into the nerve was completed. (
  • Recent progress in tissue executive and regenerative medicine has adopted the concept of utilizing endogenous cells for tissue regeneration. (
  • Funded by a $114-million grant from the Canada First Research Excellence Fund, Medicine by Design is a strategic research initiative that is working at the convergence of engineering, medicine and science to catalyze transformative discoveries in regenerative medicine and accelerate them toward clinical impact. (
  • Detailed recognition of how microenvironment impacts mechanical properties and differentiation of hMSCs will facilitate the advancement of tissue engineering and regenerative medicine. (
  • Such scaffolds uniquely combine the potential for load-bearing immediately after implantation in vivo with biological support for cell-based tissue regeneration without requiring cultivation in vitro . (
  • This book is therefore essential reading for all scientists, engineers, and physicians interested in the replacement, repair, or regeneration of human organs and tissues. (
  • The main limitation in bone regeneration is the lack of vascularization of the newly shaped tissue. (
  • The research of the Department is focused on the development of artificial tissues, mainly biodegradable scaffolds for tissue regeneration, such as nanofibers, foams, and hydrogels for the regeneration of cartilage, bone and incisional hernia. (
  • As another important component in nerve tissues, the potential of modulating cell-cell interactions as a strategy to promote regeneration has been overlooked. (
  • The Institute of Neural Regeneration and Tissue Engineering was founded with the goal of improving the lives of people who suffer from strokes, spinal cord injuries, traumatic brain injuries, neurodegenerative diseases, and other acute and chronic conditions. (
  • The theory of tissue regeneration is usually to utilize the body's own biologic resources and its reparative capability by using a target-specific biomaterial system to sponsor host stem or tissue-specific progenitor cells to the site of injury. (
  • When scaffolds incorporated with bioactive molecules are implanted tissue regeneration, particularly focusing on the strategies that enhance host stem or progenitor cells into the target-specific scaffolds, and present some of the applications of tissue regeneration. (
  • Physique 1 A strategy for tissue regeneration. (
  • Basic considerations for tissue regeneration The success of tissue regeneration relies on effective recruitment of host stem or progenitor cells into the implanted biomaterial scaffolds and induction of the infiltrating cells into tissue-specific cell lineages for functional tissue regeneration. (
  • In addition to tissue-specific adult stem cells that are primarily responsible for tissue regeneration processes, bone marrow-derived stem cells have been recognized as important cell sources that contribute their regenerating capacity to other tissues. (
  • Over the past 30 years numerous techniques and materials have been introduced and evaluated clinically and have included guided tissue regeneration , bone grafting materials, growth and other biological factors and gene therapy . (
  • In the early 2000s, the concept of tissue engineering was proposed as a new paradigm for periodontal regeneration based on molecular and cell biology . (
  • This implant was done by reconstruction through regeneration of the patient's own body tissue with the help of a unique therapy called Ossron. (
  • The Institute is set to become a world leader in tissue regeneration," says Associate Professor Mia Woodruff of QUT's Institute of Health and Biomedical Innovation. (
  • Recently, many studies have focused on the repair and regeneration of damaged articular cartilage using tissue engineering. (
  • In recent years, tissue engineering has evolved considerably, due to the problems in the biomedical area concerning tissue regeneration therapies. (
  • Moreover, sterilization strategies of scaffold are a crucial step for its application in tissue regeneration, however, the sterilization process have to maintain the structural and biochemical properties of the scaffold. (
  • IEEE Transactions on Biomedical Engineering contains basic and applied papers dealing with biomedical engineering. (
  • Papers range from engineering development in methods and techniques with biomedical applications to experimental and clinical investigations with engineering contributions. (
  • Tissue engineering (TE) is a biomedical engineering discipline that combines cells, scaffolds, and biologically active molecules into functional tissues. (
  • Gordana Vunjak-Novakovic , professor of biomedical engineering and medical sciences at Columbia University, will talk about recent findings and the future of tissue engineering, including challenges the field faces. (
  • Cell and tissue (Biomedical) engineering holds vast potential to revolutionise future patient care and meet critical health care needs regarding tissue and organ replacement. (
  • The Syracuse University team is led by Shikha Nangia, Associate Professor of Biomedical and Chemical Engineering, and Dacheng Ren, Associate Dean of Research, College of Engineering and Computer Science and Stevenson Endowed Professor of Biomedical and Chemical Engineering. (
  • Nostro and Vasconcelos are also associate professors at U of T in the department of physiology and Institute of Biomedical Engineering, respectively. (
  • It is a rapidly growing discipline covering a range of topics like materials science and tissue engineering, biomedical devices and. (
  • Dr. Boaz Arzi, professor and dentist/maxillofacial surgeon with the UC Davis School of Veterinary Medicine, joined biomedical engineers and orthopedic surgeons from UC Irvine, orthopedic surgeons from Harvard University, oral/maxillofacial surgeons from the University of Texas, and oral/maxillofacial radiologists to research the subject further. (
  • Organ-on-a-chip technology is a significant advancement in biomedical engineering that provides multiple advantages. (
  • As NYUAD Assistant Professor of Mechanical and Biomedical Engineering Mohammad A. Qasaimeh and colleagues explain in the study, "Paper-based Cell Cryopreservation," published in the journal Advanced Biosystems , a conventional filter paper made of cellulose fibers offers a simple and robust alternative, allowing for easy loading and efficient freezing of cells. (
  • 8,9 3D printing of nanocellulose hydrogels is being used in biomedical applications to support living cell growth for tissue engineering, implants, and cardiovascular devices. (
  • The rapid restoration of tissue biomechanical function remains an important challenge, emphasizing the need to replicate structural and mechanical properties using novel scaffold designs. (
  • The scaffold-free tissue engineering using spheroids is pointed out as an approach for optimizing the delivery system of cartilage construct. (
  • To the best of our knowledge, this is the first time in the scientific literature that human CPC spheroids were formed by micromolded nonadhesive hydrogel, achieving a successful scaffold-free cartilage engineering without chondrogenic stimulus (low cost). (
  • The classical tissue engineering relies on scaffold-based approaches in which the scaffold serves as a substitute for extracellular matrix. (
  • This strategy is named scaffold-free tissue engineering, pointed out as having superior results since cells are responsible for synthesizing their own extracellular matrix optimizing cell-matrix and cell-cell interactions, recreating their native tissue microenvironment and recapitulating tissue morphogenesis [ 3 ]. (
  • The pellet culture, hanging-drop, and 96-well plate have been notably used for 3D cartilage constructs in scaffold-free tissue engineering [ 5 ]. (
  • On the other hand, hydrogels, commonly used in scaffold-based cartilage tissue engineering, are responsible to impair cell-cell interaction [ 11 ]. (
  • The methods that have existed so far can be divided into two fundamentally different categories: Either one first creates small tissue building blocks, such as round cell agglomerates or flat cell sheets, and then assembles them, or one initially creates a fine, porous scaffold that is then cultivated with cells. (
  • We were able to show that the cells from neighbouring scaffold units do indeed merge and actually form a single tissue. (
  • June 18, 2010 (Beijing, China) - Chinese researchers have successfully engineered myocardial tissue in vivo using a novel scaffold and cardiomyocytelike cells derived from bone-marrow mesenchymal stem cells (BMMSCs) [1]. (
  • Presenting the results of their study, performed in laboratory rats, here at the World Congress of Cardiology 2010 , An-Lin said the purpose of the study was to construct engineered myocardial tissue using polylactic-co-glycolic acid (PLGA) for the scaffold and seed the BMMSCs on the scaffold prior to implantation. (
  • Unlike other scaffold-based cryopreservation strategies such as fiber meshes and nanofiber sheets, where the substrates must be repeatedly engineered for their use in cell cryopreservation, this paper-based method is solely based on the ready-to-use papers where cells are preserved with no significant effect on their viability and metabolic activity," said Roaa Alnemari, a former Research Assistant with Qasaimeh's lab. (
  • This classification excludes traditional transplantation of organs and tissues as well as transplantation of living cells alone as cellular therapies. (
  • Tissue engineering is an interdisciplinary field in which scaffolds, cells, and biologically active molecules are used to construct body tissues and organs. (
  • The field aims to find solutions for the repair of damaged tissues and enable the production of organs for transplantation. (
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine surveys tools that are currently available to scientists and engineers in the field and how they have been used to fabricate physiologically appropriate tissues and organs. (
  • It applies the principles of life sciences and engineering to develop biological substitutes to restore, improve, maintain, or replace different types of tissues or organs. (
  • It is an age old dream of medicine: if arbitrary kinds of tissue could be produced artificially from stem cells, then injuries could be healed with the body's own cells, and one day it might even be possible to produce artificial organs. (
  • Growing human tissues to help repair failing or damaged organs is developing as a new branch of medicine. (
  • Organ-on-a-chip technology combines engineered three-dimensional tissue within a microfluidic system to simulate the mechanics and physiology of entire organs. (
  • Fi rst steps towards developing bio-artificial replacement limbs suitable for transplantation , using an experimental approach previously used to build bioartificial organs to engineer rat forelimbs with functioning vascular and muscle tissue. (
  • Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. (
  • As such, our living microtissue-engineered rostral migratory stream can serve as an in vitro test bed for unlocking the secrets of neuroblast migration and maturation, and may potentially serve as a living transplantable construct derived from a patient's own cells that can redirect their own neuroblasts into lesion sites for sustained neuronal replacement following brain injury or neurodegenerative disease. (
  • We are pursuing two biomolecular strategies for engineering surfaces to control integrin binding in order to direct bone cell function and in vitro matrix mineralization. (
  • Furthermore, technological advancements in the field of three-dimensional (3D) tissue engineering, such as organ-on-a-chip technology, replacement of embryo cells with stem cells, and use of 3D bioprinters to design in vitro implants efficiently, are offering lucrative opportunities to the market. (
  • To engineer heart valves, cells are harvested, seeded onto or into a three-dimensional (3D) matrix platform to generate a tissue-engineered construct in vitro, and then implanted into a patient's body. (
  • To investigate the formation of the endothelial network, we performed immunofluorescence staining on the prevascularized tissues after 1-week culture in vitro. (
  • Accordingly, tissue engineering could overcome these limitations by producing in vitro cartilage substitutes. (
  • In tissue engineering therapy, cells are cultured in vitro to create a three-dimensional (3-D) tissue designed to replace the damaged cartilage. (
  • Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (
  • This novel approach would allow for a damaged tissue to be regenerated without the need for cell transplantation (Physique 1). (
  • vi) standards with respect to transplantation of tissues and genetic engineering, including cloning. (
  • as well as diagnostic techniques, drug development and tissue transplantation. (
  • Tissue engineering seeks to repair or regenerate tissues through combinations of implanted cells, biomaterial scaffolds and biologically active molecules. (
  • This classification will be used by the Tissue-Engineered Medical Products subcommittees for the organization of the development of standards for the field of tissue engineering, TEMPs, and protocols for their use. (
  • She joined Imperial in 2004 after a Postdoctoral training in the field of tissue engineering with Professor Robert Langer in the Chemical Engineering Department at the Massachusetts Institute of Technology (MIT). (
  • He continued Ross Granville Harrison's research and produced many improvements in the field of tissue culture and surgery. (
  • He has authored several articles in peer-reviewed science journals in the field of tissue engineering. (
  • We are particularly interested in the hierarchical organization of collagen in mineralized tissues and the specific mineral-matrix interactions regulating the biomechanics of calcified tissues. (
  • Guilak, F., Butler, D. L. & Goldstein, S. A. Functional tissue engineering: the role of biomechanics in articular cartilage repair. (
  • Wilson Jr. bridged the gap between engineering and biomechanics, according to Sculco. (
  • A finding by UC Riverside bioengineers could hasten development of lab-grown blood vessels and other tissues to replace and regenerate damaged tissues in human patients. (
  • The achievement suggests the method could eventually be used to deliver curcumin to help heal or regenerate injured tissue. (
  • The team's next step is to see if the MeTro gels will effectively regenerate heart tissue in the artery of a sheep. (
  • Heart valve tissue engineering is a promising alternative to prostheses for the replacement of diseased or damaged heart valves, because tissue-engineered valves have the ability to remodel, regenerate and grow. (
  • These engineered tissues give scientists a platform to study stem cells as they grow or regenerate, which could prove useful as the young field develops. (
  • Bioengineers at UC Riverside have now discovered that when delivered through magnetic hydrogels into stem cell cultures this versatile compound paradoxically also promotes the secretion of vascular endothelial growth factor, or VEGF, that helps vascular tissues grow. (
  • The paper, "Angiogenic hyaluronic acid hydrogels with curcumin-coated magnetic nanoparticles for tissue repair," is available here . (
  • In a tandem publication in another journal called Advanced Functional Materials, the team recently reported their success using the MeTro hydrogels to successfully engineer cardiac tissue. (
  • Using newly discovered microtissue engineering techniques, we have built the first self-contained, implantable constructs that mimic the architecture and function of the rostral migratory stream. (
  • Here we present a microscale 3D weaving technique to generate anisotropic 3D woven structures as the basis for novel composite scaffolds that are consolidated with a chondrocyte-hydrogel mixture into cartilage tissue constructs. (
  • As an alternative, 3D tissue constructs can be produced in the absence of scaffolds [ 2 ]. (
  • When many of them are brought into direct contact, it is possible to create large tissue constructs with a high initial cell density in a short time. (
  • This article reviews different cell types that have been used in heart valve engineering, cell sources for harvesting, phenotypic expression in constructs and suitability in heart valve tissue engineering. (
  • We successfully characterized electrical function of cardiomyocytes by optical mapping of Spontaneous Beats in unpatterned and patterned tissue constructs. (
  • We further measured mechanical function in the tissue constructs by cantilever displacement. (
  • We have also measured calcium transients in our 3D printed tissue constructs by live confocal imaging at varying frequencies. (
  • The main objective of this project is to check if the simultaneous differentiation of dental mesenchymal stem cells toward osteoblastic and endothelial lineage permits to obtain a new pre-vascularized tissue engineered bone construct. (
  • We will isolate mesenchymal stem cells from dental tissue of wisdom teeth, extracted from patients aged between 13 and 17 years old. (
  • Mesenchymal stem cells (MSCs) isolated from bone marrow have the capacity to differentiate into several mesenchymal tissues, including bone, cartilage and adipose tissue. (
  • IMSEAR at SEARO: Prospect of mesenchymal stem cells in bone tissue engineering. (
  • The basic concepts of tissue engineering with special emphasis on periodontal tissue engineering products is discussed including the use of mesenchymal stem cells in bioscaffolds and the emerging field of cell sheet technology . (
  • The TEVs also produced both collagen and elastin, which give connective tissue their strength and elasticity and are critical to the functioning of artificial blood vessels. (
  • The adult bladder is located in the anterior pelvis and is enveloped by extraperitoneal fat and connective tissue. (
  • This treatment preserves the gum tissue from developing into the territory where the bone should be, permitting the bone and connective tissue to regrow to more readily uphold the teeth. (
  • This project aims to develop a new pre-vascularized tissue engineered bone construct, using human cells of a simple and non invasive tissue source: dental pulp. (
  • To prove the viability of the tissue, researchers have attached the ears onto rats, (photos below) where they have remained healthy for extended amounts of time. (
  • The researchers mimicked the nature of human heart tissue by adding linear patterns to the gels to align heart cells and engineer cardiac tissues. (
  • The UB researchers developed a method for isolating functional smooth muscle cells from bone marrow by using a fluorescent marker protein and a tissue-specific promoter for alpha-actin, a protein found in muscles that is responsible for their ability to contract and relax. (
  • as well as planners, engineers and researchers, said Peter Granger, program leader for marine advisory services with Washington Sea Grant. (
  • The researchers also showed that the engineered myocardial tissue shares structural and functional similarities with native myocardial tissue. (
  • Speaking with heart wire , An-Lin said that while this type of research is still in its infancy, the data suggest that researchers might be able to generate cardiomyocytes that share functional and structural similarities with native heart tissue, and this would be promising in the repair of damaged heart muscle. (
  • The National Science Foundation (NSF) has awarded a $3.6 million grant to a team of researchers from five universities in a project titled "Collaborative Research: Growing Convergence Research: Infection-Resisting Resorbable Scaffolds for Engineering Human Tissue. (
  • They will be addressed by the collaborative efforts of researchers from many disciplines, from geneticists to clinical specialists to engineers. (
  • Abu Dhabi, UAE - 29 January 2020: Researchers from the Division of Engineering at NYU Abu Dhabi (NYUAD) have developed a new technique that utilizes filter paper to cryopreserve human cells, offering scientists an efficient alternative to conventional, long-term cryopreservation methods. (
  • These findings provide a promising prospect for industrial cell banks and researchers engaged in tissue engineering, drug testing, and other fields that rely on long-term, successful preservation of cells. (
  • The institute will open in 2017 with 50 to 60 researchers and clinicians in chemistry, biology, physics, technology, mathematics, engineering and applied clinical practices. (
  • Now, bits of the patient's own collagen (the tissue that gives ears their rigidity) can be grown around a custom-shaped titanium substructure. (
  • Blood vessels that have been tissue-engineered from bone marrow adult stem cells may in the future serve as a patient's own source of new blood vessels following a coronary bypass or other procedures that require vessel replacement, according to new research from the University at Buffalo Department of Chemical and Biological Engineering . (
  • We were very happy that the implant was done through autologous reconstruction using Meenakshi's own body tissue, thus, making the treatment absolutely natural and safe", said the patient's husband, Mr. Kudekar. (
  • In this paper, we summarize the development of fabrication methods for this microtissue-engineered rostral migratory stream and provide proof-of-principle evidence that it promotes and directs migration of immature neurons. (
  • Scientists at the Laboratory for Tissue Engineering and Organ Fabrication there, working to develop reconstructive plastic surgery techniques for wounded veterans, have learned how to successfully grow new sets of ears. (
  • In this review, we presented various fabrication methodologies of biomimetic and bioactive scaffolds for tissue engineering applications. (
  • In this project, we aim to develop a 3D bioprinting technology to create functional cardiac tissues via encapsulation of cardiomyocytes derived from hESCs. (
  • In Specific Aim 2, we have created an advanced vascularization technique for 3D pre-vascularized cardiac tissues with precise control of spatial organization. (
  • We study the structural and mechanical property relationships in calcified tissues at different length scales, in both healthy and diseased conditions. (
  • Often, the tissues involved require certain mechanical and structural properties for proper functioning. (
  • It provides efficient alternatives to transplants, surgical reconstruction procedures, and other mechanical devices that are used to repair damaged tissues. (
  • Literature review: The articular cartilage is a highly specialized tissue that reduces joint friction and distributes forces related to high mechanical loads between bone ends. (
  • Although tissue engineering is a useful approach to regenerating cartilage, mechanical anisotropy has not been reconstructed from a cellular organization level. (
  • The device consists of engineered anisotropic ventricular myocardium on an elastomeric thin film. (
  • This study aims to create mechanically anisotropic cartilaginous tissue using dielectrophoretic cell patterning and gel-sheet lamination. (
  • In summary, our DEP cell patterning and gel-sheet lamination techniques would be useful for reconstructing mechanically anisotropic cartilage tissues. (
  • Although all tissues optimize a structure that reduces strain, individual morphology of the tissues reflects different strategies to attain this condition. (
  • Although not yet strong enough for coronary applications, the UB group's tissue-engineered vessels (TEVs) performed similarly to native tissue in critical ways, including their morphology, their expression of several smooth muscle cell proteins, the ability to proliferate and the ability to contract in response to vasoconstrictors, one of the most important properties of blood vessels. (
  • We can optimize cell types and engineer effective tissues in our separate labs. (
  • These are the first tissue-engineered vessels to demonstrate the ability to make elastin in vivo," said Andreadis. (
  • Cite this: Heart Tissue Engineered in Vivo From Stem Cells - Medscape - Jun 18, 2010. (
  • In conclusion, the results show that among sterilization techniques used in the preset study, the best results were observed with H2O2 sterilization, since it did not significantly modify the surface structure of the PLA fibers and their in vivo response did not cause an unfavorable tissue reaction. (
  • This is a multidisciplinary team of scientists, clinicians and educationalists undertaking laboratory-based studies and clinical trials with human tissue, utilising molecular biology, tissue culture, tissue engineering models, advanced imaging, metagenomics and physiological analysis to undertake cutting edge research. (
  • A new initiative that is aimed at facilitating discussion between clinicians and basic scientists in the field of musculoskeletal tissue engineering. (
  • Scientists have been trying for years to design the "Goldilocks" of biocompatible materials that are "just right" for tissue engineering applications - not too difficult to make, elastic enough to respond to the dynamic nature of the human body, and stable enough to support effective cell growth. (
  • He created an environment here in the late 1960s and early 1970s for the design and development of implants with surgeons collaborating closely with engineers and basic scientists. (
  • But if we don't come together to create better tools to engineer the immune system, these therapies will not be usable. (
  • The research demonstrates the potential for eventually growing tissue-engineered vessels out of stem cells harvested from the patients who need them, providing a desirable alternative to the venous grafts now routinely done in patients undergoing coronary bypass operations. (
  • Soft tissue grafts strengthen slim gums or fill in spots where gums have subsided. (
  • Engineered nanomaterials (ENMs) are materials that are intentionally produced to have at least one primary dimension less than 100 nanometers. (
  • Exposure assessment and control verification can be performed to determine the potential for workplace exposure to engineered nanomaterials. (
  • The structure of the transplanted engineered myocardial tissue was similar with native heart tissue in that it was positive for the cardiomyocyte-specific protein troponin I and had a natural structure similar to native tissue with the presence of gap junctions and desomosomes, which are needed for tissue conduction," lead investigator Dr Lv An-Lin (Xijing Hospital of the Fourth Military Medical University, Xi'an, China) told heart wire . (
  • Engineers are developing new systems to use genetic information, sense small changes in the body, assess new drugs, and deliver vaccines. (
  • In recent times many companies have developed therapeutic strategies able to delivery engineered genetic products within the human tissues, and if the present study will confirm that MEF2A is associated with atherosclerosis, a targeted delivery of a modified version of the MEF2A gene within the arterial cells might represent a future therapeutic option able to revert atherosclerosis in subject with occluded arteries, or at least to prevent future cardiovascular events. (
  • In the hepatitis area, advances include growth of hepatitis A virus in tissue-culture systems, use of antigens for IgM immunoassays, the recent production of hepatitis B core antigen from bacteria through genetic engineering, and development of immunoassays for both antigen and antibody associated with the 'delta' antigen. (
  • Biodegradable polymer scaffolds for tissue engineering. (
  • The aim of the present study was designed to analyze the effects of different sterilization techniques, i.e. ethylene oxide (ETO), gamma radiation (GR) and hydrogen peroxide- based plasma (H2O2) in biodegradable PLA scaffolds, and to determine the best sterilization technique to render a sterile product with minimal degradation and deformation, and good tissue response. (
  • biomaterial for tissue engineering? (
  • A new - and heart-warming - biomaterial for tissue engineering? (
  • While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, etc. (
  • Neural tissue engineering holds great promise in repairing damaged nerve tissues. (
  • In order to recapitulate the ocular fundus functions, neural supporting cells such as retinal pigment epithelial (RPE) cells were cultured within a three-dimensional microfluidic device, and cell responses at the tissue level to changes in the microenvironment were analyzed. (
  • Automated multi-beat tissue Doppler echocardiography analysis using deep neural networks. (
  • This engineered microtissue emulates the dense cord-like bundles of astrocytic somata and processes that are the hallmark anatomical feature of the glial tube. (
  • With these approaches they are advancing mechanistic understanding of stem cell biology, tissue engineering and oral diseases, towards translational applications. (
  • Until now, there have been two completely different approaches to producing artificial tissue. (
  • The final goal in is to create 3-D models of skeletal muscles in space, which show blood-vessel and neuron growth within the artificial tissue. (
  • Vunjak-Novakovic directs the Laboratory for Stem Cells and Tissue Engineering at Columbia. (
  • Tissue engineering is an interdisciplinary field that involves mainly medical area, biology and engineering. (
  • Other current research interests are (brain) cancer biology, tissue engineering and bio-electronic circuits. (
  • The mechanism where a single hair follicle could be turned into hundreds or thousands of hair follicles is not 'cloning' but tissue engineering or what is sometimes called cell therapy. (
  • While optimal cell environment is directed at a common final goal, the course in attaining tissue specificity must take into account progressive changes that accent the functional development. (
  • For example, it can happen that the cell spheres change their size or shape and the tissue ends up with different properties than desired. (
  • Within the central nervous system, there are considerably more cell-cell communications as compared to cell-ECM interactions, since the ECM only contributes 10%-20% of the total tissue volume. (
  • Also, based on findings on cell functions at the tissue level obtained by the analysis of the organ on a chip, cell delivery therapy was investigated. (
  • Additionally, because abnormal cell growth easily infiltrates and destroys surrounding bony tissues, wide surgical excision is required to treat this disorder. (
  • 2Department of Tissue Engineering and Applied Cell Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. (
  • The results indicate that the embedded chondrocytes remained viable and reconstructed cartilaginous tissue along the patterned cell array. (
  • An international team led by the Wyss Institute recently used microfabrication techniques to design a new micropatterned hydrogel that shows great promise for tissue engineering - cardiac tissue in particular. (
  • and Sara Nunes Vasconcelos , a scientist at UHN's Toronto General Hospital Research Institute, are using stem cells to generate tissues containing insulin-secreting cells for transplants. (
  • It helps us understand some of the key biological principles for our tissue engineering designs, and it informs readers how important the converging, holistic approach is for the future development of the field. (
  • It is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physio-chemical factors to improve or replace biological functions. (
  • The potential application of tissue engineering for treating human hair loss is obvious and exciting. (
  • In this Monday, July 2, 2012 photo Cathryn Sundback, director of the tissue engineering lab at Massachusetts General Hospital, holds a laboratory rat implanted with a human-scaled ear made from sheep cells at the lab in Boston. (
  • The case for applying tissue engineering methodologies to instruct human organoid morphogenesis. (
  • It incorporates an elastic protein called tropoelastin, which is found in all elastic human tissues. (
  • This project aims to test the hypothesis that World Trade Center (WTC)-related trace elements remained in human tissues years after 9/11/2001 and may be useful in the development of biomarkers of WTC exposure. (