Tissue Donors
Deltaretrovirus Infections
Deltaretrovirus Antibodies
Nucleic Acid Amplification Techniques
Tissue and Organ Procurement
Effect of MTHFR 677C>T on plasma total homocysteine levels in renal graft recipients. (1/3426)
BACKGROUND: Hyperhomocysteinemia is an established, independent risk factor for vascular disease morbidity and mortality. The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T has been shown to result in increased total homocysteine concentrations on the basis of low folate levels caused by a decreased enzyme activity. The effect of this polymorphism on total homocysteine and folate plasma levels in renal transplant patients is unknown. METHODS: We screened 636 kidney graft recipients for the presence of the MTHFR C677T gene polymorphism. The major determinants of total homocysteine and folate plasma concentrations of 63 patients, who were identified to be homozygous for this gene polymorphism compared with heterozygotes (N = 63), and patients with wild-type alleles (N = 63), who were matched for sex, age, glomerular filtration rate (GFR), and body mass index, were identified by analysis of covariance. The variables included sex, age, GFR, body mass index, time since transplantation, folate and vitamin B12 levels, the use of azathioprine, and the MTHFR genotype. To investigate the impact of the kidney donor MTHFR genotype on total homocysteine and folate plasma concentrations, a similar model was applied in 111 kidney graft recipients with stable graft function, in whom the kidney donor C677T MTHFR gene polymorphism was determined. RESULTS: The allele frequency of the C677T polymorphism in the MTHFR gene was 0.313 in the whole study population [wild-type (CC), 301; heterozygous (CT), 272; and homozygous mutant (TT), 63 patients, respectively] and showed no difference in the patient subgroups with various renal diseases. The MTHFR C677T gene polymorphism significantly influenced total homocysteine and folate plasma concentrations in renal transplant recipients (P = 0.0009 and P = 0.0002, respectively). Furthermore, a significant influence of the GFR (P = 0.0001), folate levels (P = 0.0001), age (P = 0.0001), body mass index (P = 0.0001), gender (P = 0.0005), and vitamin B12 levels (P = 0.004) on total homocysteine concentrations was observed. The donor MTHFR gene polymorphism had no influence on total homocysteine and folate levels. Geometric mean total homocysteine levels in patients homozygous for the mutant MTHFR allele were 18.6 micromol/liter compared with 14.6 micromol/liter and 14.9 micromol/liter in patients heterozygous for the MTHFR gene polymorphism and those with wild-type alleles (P < 0.05 for TT vs. CT and CC). Geometric mean folate levels were lower in CT and TT patients (11.2 and 10.2 nmol/liter) compared with CC patients (13.6 nmol/liter, P < 0.05 vs. CT and TT). CONCLUSIONS: This study demonstrates that homozygosity for the C677T polymorphism in the MTHFR gene significantly increases total homocysteine concentrations and lowers folate levels in kidney graft recipients, even in patients with excellent renal function (GFR more than median). These findings have important implications for risk evaluation and vitamin intervention therapy in these patients who carry an increased risk for the development of cardiovascular disease. (+info)A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/mycophenolate mofetil in renal transplant recipients. (2/3426)
BACKGROUND: Between September 20, 1995 and September 20, 1997, 208 adult patients undergoing renal transplantation were randomized to receive tacrolimus/prednisone (n=106) or tacrolimus/prednisone/mycophenolate mofetil (n=102), with the goal of reducing the incidence of rejection. METHODS: The mean recipient age was 50.7+/-13.7 years. Sixty-three (30.3%) patients were 60 years of age or older at the time of transplantation. The mean donor age was 34.5+/-21.7 years. The mean cold ischemia time was 30.5+/-9.2 hr. The mean follow-up is 15+/-7 months. RESULTS: The overall 1-year actuarial patient survival was 94%; the overall 1-year actuarial graft survival was 87%. When the patient and graft survival data were stratified to recipients under the age of 60 who did not have delayed graft function, the overall 1-year actuarial patient survival was 97%, and the corresponding 1-year actuarial graft survival was 93%. There were no differences between the two groups. The overall incidence of rejection was 36%; in the double-therapy group, it was 44%, whereas in the triple therapy group, it was 27% (P=0.014). The mean serum creatinine was 1.6+/-0.8 mg/dl. A total of 36% of the successfully transplanted patients were taken off prednisone; 32% of the patients were taken off antihypertensive medications. The incidence of delayed graft function was 21%, the incidence of cytomegalovirus was 12.5%, and the initial and final incidences of posttransplant insulin-dependent diabetes mellitus were 7.0% and 2.9%; again, there was no difference between the two groups. CONCLUSIONS: This trial suggests that the combination of tacrolimus, steroids, and mycophenolate mofetil is associated with excellent patient and graft survival and a lower incidence of rejection than the combination of tacrolimus and steroids. (+info)Pediatric renal transplantation under tacrolimus-based immunosuppression. (3/3426)
BACKGROUND: Tacrolimus has been used as a primary immunosuppressive agent in adult and pediatric renal transplant recipients, with reasonable outcomes. Methods. Between December 14, 1989 and December 31, 1996, 82 pediatric renal transplantations alone were performed under tacrolimus-based immunosuppression without induction anti-lymphocyte antibody therapy. Patients undergoing concomitant or prior liver and/or intestinal transplantation were not included in the analysis. The mean recipient age was 10.6+/-5.2 years (range: 0.7-17.9). Eighteen (22%) cases were repeat transplantations, and 6 (7%) were in patients with panel-reactive antibody levels over 40%. Thirty-four (41%) cases were with living donors, and 48 (59%) were with cadaveric donors. The mean donor age was 27.3+/-14.6 years (range: 0.7-50), and the mean cold ischemia time in the cadaveric cases was 26.5+/-8.8 hr. The mean number of HLA matches and mismatches was 2.8+/-1.2 and 2.9+/-1.3; there were five (6%) O-Ag mismatches. The mean follow-up was 4.0+/-0.2 years. RESULTS: The 1- and 4-year actuarial patient survival was 99% and 94%. The 1- and 4-year actuarial graft survival was 98% and 84%. The mean serum creatinine was 1.1+/-0.5 mg/dl, and the corresponding calculated creatinine clearance was 88+/-25 ml/min/1.73 m2. A total of 66% of successfully transplanted patients were withdrawn from prednisone. In children who were withdrawn from steroids, the mean standard deviation height scores (Z-score) at the time of transplantation and at 1 and 4 years were -2.3+/-2.0, -1.7+/-1.0, and +0.36+/-1.5. Eighty-six percent of successfully transplanted patients were not taking anti-hypertensive medications. The incidence of acute rejection was 44%; between December 1989 and December 1993, it was 63%, and between January 1994 and December 1996, it was 23% (P=0.0003). The incidence of steroid-resistant rejection was 5%. The incidence of delayed graft function was 5%, and 2% of patients required dialysis within 1 week of transplantation. The incidence of cytomegalovirus was 13%; between December 1989 and December 1992, it was 17%, and between January 1993 and December 1996, it was 12%. The incidence of early Epstein-Barr virus-related posttransplant lymphoproliferative disorder (PTLD) was 9%; between December 1989 and December 1992, it was 17%, and between January 1993 and December 1996, it was 4%. All of the early PTLD cases were treated successfully with temporary cessation of immunosuppression and institution of antiviral therapy, without patient or graft loss. CONCLUSIONS: These data demonstrate the short- and medium-term efficacy of tacrolimus-based immunosuppression in pediatric renal transplant recipients, with reasonable patient and graft survival, routine achievement of steroid and anti-hypertensive medication withdrawal, gratifying increases in growth, and, with further experience, a decreasing incidence of both rejection and PTLD. (+info)Split liver transplantation. (4/3426)
OBJECTIVE: This study reviews the indications, technical aspects, and experience with ex vivo and in situ split liver transplantation. BACKGROUND: The shortage of cadaveric donor livers is the most significant factor inhibiting further application of liver transplantation for patients with end-stage liver disease. Pediatric recipients, although they represent only 15% to 20% of the liver transplant registrants, suffer the greatest from the scarcity of size-matched cadaveric organs. Split liver transplantation provides an ideal means to expand the donor pool for both children and adults. METHODS: This review describes the evolution of split liver transplantation from reduced liver transplantation and living-related liver transplantation. The two types of split liver transplantation, ex vivo and in situ, are compared and contrasted, including the technique, selection of patients for each procedure, and the most current results. RESULTS: Ex vivo splitting of the liver is performed on the bench after removal from the cadaver. It is usually divided into two grafts: segments 2 and 3 for children, and segments 4 to 8 for adults. Since 1990, 349 ex vivo grafts have been reported. Until recently, graft and patient survival rates have been lower and postoperative complication rates higher in ex vivo split grafts than in whole organ cadaveric transplantation. Further, the use of ex vivo split grafts has been relegated to the elective adult patient because of the high incidence of graft dysfunction (right graft) when placed in an emergent patient. Reasons for the poor function of ex vivo splits except in elective patients have focused on graft damage due to prolonged cold ischemia times and rewarming during the long benching procedure. In situ liver splitting is accomplished in a manner identical to the living donor procurement. This technique for liver splitting results in the same graft types as in the ex vivo technique. However, graft and patient survival rates reported for in situ split livers have exceeded 85% and 90%, respectively, with a lower incidence of postoperative complications, including biliary and reoperation for bleeding. These improved results have also been observed in the urgent patient. CONCLUSION: Splitting of the cadaveric liver expands the donor pool of organs and may eliminate the need for living-related donation for children. Recent experience with the ex vivo technique, if applied to elective patients, results in patient and graft survival rates comparable to whole-organ transplantation, although postoperative complication rates are higher. In situ splitting provides two grafts of optimal quality that can be applied to the entire spectrum of transplant recipients: it is the method of choice for expanding the cadaver liver donor pool. (+info)High-risk donors: expanding donor criteria. (5/3426)
Advances in the surgical techniques, preservation solutions, and methods for predicting eventual long-term renal function from expanded donors will be critical in allowing precise selection criteria for kidneys for transplantation, resulting in the optimum use of a scarce and precious resource. Until other options such as xenotransplantation or tissue engineering become realistic, the challenge for the millennium will be to identify which donor organs previously considered suboptimal can be safely used to expand the organ donor pool. (+info)Correction of bone marrow failure in dyskeratosis congenita by bone marrow transplantation. (6/3426)
Dyskeratosis congenita is recognized by its dermal lesions and constitutional aplastic anemia in some cases. We report successful allogeneic bone marrow transplantation in two siblings with this disease from their sister, and their long term follow-up. We used reduced doses of cyclophosphamide and busulfan for conditioning instead of total body irradiation. Also, we report late adverse effects of transplantation which are not distinguishable from the natural course of disease. (+info)Relaxin secretion by human granulosa cell culture is predictive of in-vitro fertilization-embryo transfer success. (7/3426)
We have developed a cell culture system for human luteinizing granulosa cells which supports the timely and dynamic secretion of oestrogen, progesterone and relaxin in patterns that mimic serum concentrations of these hormones during the luteal phase of the menstrual cycle. There was a wide variation in the amount of relaxin secreted by the cultured cells for the 69 patients studied. As relaxin production was generally maximal by day 10 of culture, comparisons were made at this time point. It was observed that most of the conceptions occurred in patients with higher relaxin secretion in vitro. All cycles with relaxin > 800 pg/ml on day 10 had a term pregnancy while only 13% of cycles with relaxin < 200 pg/ml had term pregnancies. A limited number of cycles from donor/recipient cycles did not show similar results. Steroid concentrations were not predictive of conception. These results demonstrated that in-vitro production of relaxin is predictive of implantation success in in-vitro fertilization (IVF)-embryo transfer cycles. This supports the hypothesis that relaxin may be involved in implantation and that lowered relaxin concentrations may be a partial cause of poor pregnancy rates after IVF. (+info)Short-term toxicity in pediatric marrow transplantation using related and unrelated donors. (8/3426)
The use of volunteer, unrelated donors has substantially increased the number of potential donors for pediatric marrow transplantation during the past few years. We describe our single institution experience of short-term toxicity after pediatric marrow transplantation using sibling or unrelated donors. Fully matched (A, B and DR loci) donors were employed in 94% of the cases in both groups. Conditioning of similar intensity and uniform supportive care were employed in the two groups. Both primary non-engraftment and secondary graft failure were more common among recipients of unmanipulated URD grafts. Clinically significant (grades III-IV) acute GVHD and toxic mortality during the immediate post-transplant period were also higher in this group of patients. Pediatric marrow transplantation using volunteer, unrelated donors appears to be associated with an increased incidence of procedure-related toxic complications. (+info)The most common deltaretrovirus infection is HIV, which has become a major global health concern since its discovery in the early 1980s. HIV primarily infects CD4+ T cells, which are essential for cell-mediated immunity and immune responses. As HIV progressively destroys these cells, the body becomes less able to fight off infections and cancers.
Other deltaretrovirus infections include SIV, which affects nonhuman primates such as monkeys and chimpanzees, and FIV, which affects domestic cats. These viruses are similar to HIV in terms of their molecular structure and replication strategies but have some differences in their host range and disease progression.
Deltaretrovirus infections can be diagnosed through blood tests that detect the presence of viral antigens or genetic material. Treatment typically involves antiretroviral therapy (ART), which combines several drugs to suppress viral replication and slow disease progression. However, the virus can develop resistance to these drugs over time, making it essential to monitor treatment response and adjust medications as needed.
Prevention strategies for deltaretrovirus infections include safe sex practices such as using condoms, pre-exposure prophylaxis (PrEP) medication for high-risk individuals, and avoiding sharing needles or other injection equipment. Vaccines are also being developed to prevent HIV and other deltaretrovirus infections.
Human Tissue Act 2004
Online Donor Registry (Ontario)
Elizabeth Craze
HLA B7-DR15-DQ6
HLA A1-B8 haplotype
HLA-DQ8
HLA DR3-DQ2
HLA-A*02
Lying-In Hospital
Functional genomics
Progeroid syndromes
Werner syndrome
Brain death
Tissue typing
Organ donation in Australia
Darvadstrocel
Mixed lymphocyte reaction
Chen Chao-long
Neuroregeneration
Masculinizing hormone therapy
List of presidential proclamations by George W. Bush
Screening of potential sperm bank donors
Kidney transplantation
Etretinate
Organ printing
Corneal transplantation
Political positions of Elizabeth Warren
Stem cell therapy for macular degeneration
Keratoconus
Corneal opacity
Blood Emergency Readiness Corps
Scuba set
Bob Casey Sr.
Metabolism
Food web
Follicular dendritic cells
Viral synapse
Mitochondrial DNA
Body broker
List of Puerto Rican scientists and inventors
Scalp reconstruction
Ömer Özkan
LECT2
Iron overload
Blood doping
Field Museum of Natural History
Stimulus-triggered acquisition of pluripotency
Robert E. Murray
Lunenfeld-Tanenbaum Research Institute
Biomedical Tissue Services
Alpha-1 antitrypsin
Histone methyltransferase
Journal of Orthopaedic Trauma
Binding selectivity
Subash Gupta
Organ donation in India
Allogeneic processed thymus tissue
Liver support system
Luciferase
Glaucoma
Public Health Service
Inter-Agency Guidelines for
Screening Donors of Blood, Plasma,
Organs, Tissues, and Semen for Evidence
NIH Guide: AFFECTING GRAFT SURVIVAL WITH DONOR IMMUNE TISSUE
Epidemiologic Notes and Reports Testing Donors of Organs, Tissues, a
Why I'm Still a Tissue Donor - ICIJ
West Nile Virus workshop: scientific considerations for tissue donors - PubMed
Table - West Nile Virus RNA in Tissues from Donor Associated with Transmission to Organ Transplant Recipients - Volume 19,...
Gene Expression in 54 tissues from GTEx RNA-seq of 17382 samples, 948 donors (V8, Aug 2019) (POMC)
Testing donors of organs, tissues, and semen for antibody to human T-lymphotropic virus type III/lymphadenopathy-associated...
Colorado Moves to Yes-Carryover Process for Organ, Eye and Tissue Donor Registry - Donor Alliance
Saskatchewan Organ and Tissue Donor Registry | Organ and Tissue Donor Registry | Government of Saskatchewan
Register as an Organ, Eye and Tissue Donor - Save Lives
Children as potential deceased organ and tissue donors - Result
Subjects: Tissue Donors - Digital Collections - National Library of Medicine Search Results
Scientists triple storage time of human donor livers
Results of search for 'su:{Tissue Donors}'
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WHO HQ Library catalog
Type O Blood Donors Needed Immediately - South Texas Blood & Tissue
Clinical Utility of COVID-19 Real Time-Polymerase Chain Reaction Testing of Ocular Tissues of Non-COVID-19 Cornea Donors Deemed...
ACL Patellar Tendon, Hamstring, or Donor Graft Options
April: National Organ and Tissue Donor Awareness Month
Tendons Archives - Donor Tissue Bank of Victoria (DTBV)
A review of lung transplant donor acceptability criteria
NLM Classification 2020 Summer Edition Now Available. NLM Technical Bulletin. 2020 Sep-Oct
Joshua Abbott Organ and Tissue Donor Registry Archives - Tampa Dispatch
National Donor Day - Donate Life America
Collaborations Reporting System - HHS Tissue and Organ Donor Epidemiology Study (TODES) Working Group
Blood Drive in Conjunction with the South Texas Blood Donor & Tissue Center
NIH-funded study finds donor age not a factor in most corneal transplants | National Eye Institute
Transplantation18
- These studies have the potential to help develop protocols for enhancing solid organ graft survival by infusion of donor cells prior to or after transplantation. (nih.gov)
- Donor specific transplant tolerance has been achieved for solid organ transplantation in animal models via induction regimens using donor immunocompetent tissue, e.g., bone marrow and peripheral blood. (nih.gov)
- I can specify if there are tissues I do not what to donate, or if I object to my tissue being used either for research or transplantation. (icij.org)
- The goal is to determine how to fill gaps in knowledge of WNV and tissue donation and transplantation by pursuing relevant scientific studies. (nih.gov)
- Workshop participants included subject-matter experts from the U.S. Food and Drug Administration, the Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Health Canada, the Public Health Agency of Canada, AATB-accredited tissue banks including reproductive tissue banks, accredited eye banks of the Eye Bank Association of America, testing laboratories, and infectious disease and organ transplantation professionals. (nih.gov)
- Delivering viable organs to matching recipients within the window of viability can often be the most challenging aspect of organ transplantation," said Seila Selimovic, Ph.D., director of NIBIB's Engineered Tissues program. (nih.gov)
- Organ and tissue transplantation in the European union : management of difficulties and health risks linked to donors / edited by Yvon Englert. (who.int)
- Ethics, access and safety in tissue and organ transplantation : issues of global concern, Madrid, Spain, 6-9 October 2003 : report. (who.int)
- Clinical Utility of COVID-19 Real Time-Polymerase Chain Reaction Testing of Ocular Tissues of Non-COVID-19 Cornea Donors Deemed Suitable for Corneal Retrieval and Transplantation. (bvsalud.org)
- The expression of SARS-CoV-2 RNA was assessed by reverse transcription - polymerase chain reaction in corneal rims and conjunctival tissues from 100 donors who were found suitable for transplantation as per the donor screening guidelines of the Global Alliance of Eye Bank Associations . (bvsalud.org)
- The overall prevalence of SARS-CoV-2 was 1% (2% for conjunctival and 0% for corneal samples, P value = 0.5) in the donors who were found suitable for cornea recovery and transplantation . (bvsalud.org)
- The findings of exceptionally low positive rates in our samples validate the criticality of history -based donor screening and do not support the necessity of postmortem PCR testing as a criterion for procurement and subsequent use for corneal transplantation . (bvsalud.org)
- Organ donation takes healthy organs and tissues from one person for transplantation into another. (medlineplus.gov)
- Organ Procurement Organizations (OPOs) are nonprofit organizations responsible for recovering organs from donors for transplantation in the United States. (nih.gov)
- Traumatic scars (i.e. from an accident) can be treated with follicular unit hair transplantation as the hair grows quite well in scar tissue, as long as the scar is not thickened (hypertrophic). (bernsteinmedical.com)
- Organ donation and transplantation is removing an organ from one person (the donor) and surgically placing it in another (the recipient) whose organ has failed. (clevelandclinic.org)
- In addition to allogeneic HCT, procedures associated with high risk of GVHD include transplantation of solid organs containing lymphoid tissue and transfusion of unirradiated blood products. (medscape.com)
- n 2271) But with recent advances in the biomedical sciences, a new crime against the dignity of the embryo as a human being is emerging: the use of foetal tissue as 'biological material' for transplantation. (ewtn.com)
Transplant15
- Some tissue banks may appear disrespectful of the gifts they receive, tossing around terms like "gutter" tissue when referring to material that doesn't meet transplant standards but is then used for research on developing new products. (icij.org)
- When I signed my donor card at the Department of Motor Vehicles, I was agreeing to give my organs and tissue for transplant or research. (icij.org)
- Previously, human livers were only viable for an average of nine hours, but the new method of preservation maintains liver tissue for up to 27 hours, giving transplant doctors and patients a much longer timeframe to work with. (nih.gov)
- National Donor Day is also a day to recognize those who have given and received the gift of life through organ, eye and tissue donation, are currently waiting for a lifesaving transplant, and those who died waiting because an organ was not donated in time. (donatelife.net)
- In a traditional corneal transplant, the central part of the cornea is removed and a donor cornea is sutured in its place. (nih.gov)
- Ten years after a transplant, a cornea from a 71-year-old donor is likely to remain as healthy as a cornea from a donor half that age, according to a study funded by the National Institutes of Health. (nih.gov)
- Corneas from donors over age 71 perform slightly less well, but still remain healthy for the majority of transplant recipients after 10 years, the study found. (nih.gov)
- We found that transplant success rates were similar across a broad range of donor ages. (nih.gov)
- The corneas were given to patients, without respect to patient age, through a transplant procedure called penetrating keratoplasty, in which the central part of the damaged cornea is removed, and a full-thickness donor cornea is sutured in its place. (nih.gov)
- That prompted an expansion of the study to determine if donor age would affect transplant viability 10 years after the procedure. (nih.gov)
- Can Hair Transplant Use Cloned Hair from Someone Else's Donor Tissue? (bernsteinmedical.com)
- If I need an organ or tissue transplant, what do I need to do? (clevelandclinic.org)
- Keep up with the news and stories about donor families and transplant recipients. (lcnw.org)
- That's why living donors are often family or friends of the transplant recipient. (nih.gov)
- Ffrench-Constant & Mathews, 1994) Although there are scattered re ports of attempts to transplant neural tissues in mammals going back before the turn of the century, it is only two decades since several laboratories in the USA and Sweden first characterized the necessary conditions to yield reliable graft survival. (ewtn.com)
Listed an organ donor1
- I have been listed an organ donor since about 1975, when it first was initiated in my state. (icij.org)
Donation25
- After eight months of research, I have learned a lot that might turn me off tissue donation. (icij.org)
- Previously, residents were required to confirm the choice to register each time they renewed their license or state ID because prior decisions on organ, eye and tissue donation were not carried over. (donoralliance.org)
- For more information on organ, eye and tissue donation, visit the About Donation section of our website. (donoralliance.org)
- Registering your decision for organ and/or tissue donation is easy - all you need is your Saskatchewan Health Services Card number, first and last name and date of birth. (saskatchewan.ca)
- The Surgeon General's Workshop on Increasing Organ Donation: Background Papers: 'Ninety-Four Percent Awareness and Still Not Enough Donors: Can Public Education Increase Organ Donation? (nih.gov)
- The Surgeon General's Workshop on Increasing Organ Donation: Background Papers: 'Increasing Organ and Tissue Donation: What Are the Obstacles, What Are Our Options? (nih.gov)
- Celebrated in April each year, NDLM features an entire month of local, regional and national activities to help encourage Americans to register as organ, eye and tissue donors and to celebrate those that have saved lives through the gift of donation. (greatermkemen.com)
- As Americans, we can demonstrate our commitment to one another in the most difficult of circumstances through organ, tissue, stem cell, and blood donation. (greatermkemen.com)
- There is no age limit for donors, and because some conditions and blood types are more common in certain ethnic and racial populations, the Department of Health and Human Services especially encourages minorities to consider donation. (greatermkemen.com)
- Find out how you can register your wish to be considered for tissue donation. (dtbv.org.au)
- Tissue donation can enhance and even save people's lives. (dtbv.org.au)
- Donate Life America is committed to increasing the number of lives saved and healed through organ, eye and tissue donation. (donatelife.net)
- Observed every year on February 14th, National Donor Day is an observance dedicated to spreading awareness and education about organ, eye and tissue donation. (donatelife.net)
- National Donor Day is a time to focus on all types of donation- organ , eye , tissue , blood, platelets and marrow. (donatelife.net)
- In addition to registering to be an organ, eye and tissue donor or contributing to the DLA cause , you can also download our National Donor Day graphics, Donor Day Flyer and Printable Valentine Cards (all available in English and Spanish) to raise awareness about donation throughout social media-link these images to other resources for your friends and followers to utilize within your local and online communities. (donatelife.net)
- Explore more things you can do to support Donate Life America and advocate for organ, eye and tissue donation every day of the year. (donatelife.net)
- As healthcare professionals across Florida call attention to the importance of organ donation in April during National Donate Life Month, a west Florida man is particularly grateful for one donor among the more than 11.8 million enrolled in the state's Joshua Abbott Organ and Tissue Donor Registry. (tampadispatch.com)
- Organ donation is the act of taking healthy organs and tissues from one person and giving them to someone else. (nih.gov)
- No. It's common for people to think that signing up to be an organ donor includes brain donation, but the purpose and the process are different. (nih.gov)
- To learn more about the brain donation process, why many brains are needed from diverse populations and ages, and how to become a brain donor, visit NIA's article - Brain Donation: A Gift for Generations . (nih.gov)
- Living donation has a different process than that of a deceased donor donation. (nih.gov)
- Organ donation is the process of surgically removing an organ or tissue from one person (the organ donor) and placing it into another person (the recipient). (clevelandclinic.org)
- There is no cost to the donor's family or estate for the donation of organs, tissue or eyes. (clevelandclinic.org)
- Going forward, we will provide you with opportunities to honor your loved one and their gift of life, including a Gift of Life Donor Medal and invitations to our annual Donation Celebrations . (lcnw.org)
- Last year, LifeCenter Northwest facilitated the donation of 921 organs from 310 deceased organ donors for life-saving transplants from across Alaska, Montana, northern Idaho and Washington. (lcnw.org)
Organs and tissues3
- select organs and tissues of your choosing. (saskatchewan.ca)
- But some organs and tissues can be donated while the donor is alive. (medlineplus.gov)
- What organs and tissues can be transplanted? (clevelandclinic.org)
Registry11
- Colorado is adopting the yes-carryover process for the state's organ, eye and tissue donor registry with changes to the process beginning September 15, 2017. (donoralliance.org)
- This process ensures that the rights and responsibilities of those who have made their decision to join the Colorado Donor Registry known are in line with current state law. (donoralliance.org)
- The yes-carryover process will ensure that the registry process meets the intent and requirements of the Uniform Anatomical Gift Act (UAGA), allowing residents who have made the choice to register as organ, eye and tissue donors to remain on the donor registry, without the hassle of renewing that choice repeatedly throughout their adult lives. (donoralliance.org)
- The move to yes-carryover designation does not change residents' ability to remove their names from the donor registry at any time. (donoralliance.org)
- For more information on what it means to join the donor registry, please visit our FAQ page . (donatelifecolorado.org)
- Each organ or tissue donor can save many lives, and becoming one is simple: join your State's donor registry, indicate your decision on your driver's license, and inform loved ones of your decision. (greatermkemen.com)
- Also be sure to keep your information, such as a current mailing address, up to date in your state's donor registry. (nih.gov)
- You might join a donor registry. (clevelandclinic.org)
- A registry is more than just an expression of interest in becoming a donor. (clevelandclinic.org)
- For more information, go to www.lifebanc.org and click on donor registry. (clevelandclinic.org)
- Donor registry information for any state might be obtained from www.donatelife.net . (clevelandclinic.org)
Transplants6
- With the exception of transplants between identical twins, the only known way to accomplish this is to induce a specific non-responsive (tolerant) state, whereby the grafted tissue is ultimately not recognized as foreign. (nih.gov)
- The change is also expected to help increase the number of registered donors in Colorado, therefore resulting in more lifesaving transplants, which will be a great public health benefit to all. (donoralliance.org)
- Transplants rely on the generosity of organ, eye and tissue donors, and there are not enough donors to meet the need. (donatelife.net)
- The Cornea Donor Study, funded by NIH's National Eye Institute (NEI), found that 10-year success rates remained steady at 75 percent for corneal transplants from donors 34-71 years old. (nih.gov)
- In 2008, they reported that the five-year success rate was identical-86 percent-for transplants from donors aged 12-65 and those aged 66-75. (nih.gov)
- This is compounded by the 'careful' terminology used in the journal articles, which serves to disguise the ugly truth that foetuses are being used as donors in experimental brain tissue transplants. (ewtn.com)
Interaction between donor and recipient1
- Graft versus host disease (GVHD) is an immune-mediated condition resulting from a complex interaction between donor and recipient adaptive immunity. (medscape.com)
Recipients4
- Retrospective testing of blood donors using first generation tests such as immunodiffusion to detect HBsAg, found that 52%-69% of recipients of HBsAg-positive blood developed hepatitis B (8,9). (cdc.gov)
- In addition, recipients of blood from paid donors were at higher risk of developing post-transfusion hepatitis than were recipients of blood from non-paid donors (10,11). (cdc.gov)
- None of the recipients from the donors were reported to have any systemic adverse event after keratoplasty until the follow-up of 6 weeks. (bvsalud.org)
- Through the UNOS Organ Center, organ donors are matched to waiting recipients 24 hours a day, 365 days a year. (clevelandclinic.org)
20221
- The Shavano Park Women hosted a Blood Drive with the South Texas Blood and Tissue Center (STBTC) on April 30, 2022, at Shavano Park City Hall. (spwnp.org)
Cornea5
- In the United States, three-fourths of cornea donors are within this age range, and one-third of donors are at the upper end of the range, from 61-70 years old. (nih.gov)
- Our study supports continued expansion of the corneal donor pool beyond age 65," said study co-chair Edward J. Holland, M.D., professor of ophthalmology at the University of Cincinnati and director of the Cornea Service at the Cincinnati Eye Institute. (nih.gov)
- It involves removing a portion of the damaged cornea and grafting corneal tissue from a deceased donor in its place. (nih.gov)
- The Cornea Donor Study was designed to address whether making use of donor corneas across the full range of ages available might help solve this problem," said Maryann Redford, D.D.S, M.P.H, a clinical research program director at NEI. (nih.gov)
- One of the most commonly transplanted tissues is the cornea, the transparent covering over the eye. (nih.gov)
Deferral2
- Transmission of HBV by transfusion of blood or blood products is rare because of routine screening of blood donors for HBsAg and because of current donor selection and deferral procedures. (cdc.gov)
- Given current scrutiny of the blood donor deferral policy of Men who have Sex with Men (MSM), interpretations between MSM and non-MSM respondents also were compared. (cdc.gov)
20212
- Of 200 ocular tissues (100 corneal and 100 conjunctival) from the same 1 eye of 100 surgical-intended donors , between September 2020 and April 2021, the overall positivity rate for SARS-CoV-2 was â ¼1% (2/200). (bvsalud.org)
- You're never too old to make a difference - as of 2021, the oldest organ donor in the United States was 92. (nih.gov)
Recipient2
- A combination of more sensitive third-generation tests (reversed passive hemagglutination and radioimmunoassay (RIA)) for HBsAg screening and exclusive use of non-paid donors reduced the rate of post-transfusion hepatitis B to 0.3%-0.9%/transfusion recipient by the mid-1970s (12,13). (cdc.gov)
- You can also read through our Stories of Hope , inspiring organ, eye and tissue donor and recipient stories. (donatelife.net)
HTLV-III2
Lymphoid2
- We present here an analysis of lymphocyte localization and T cell subset composition across the human GI tract including mucosal sites (jejunum, ileum, colon), gut-associated lymphoid tissues (isolated lymphoid follicles (ILFs), Peyer's patches (PPs), appendix), and mesenteric lymph nodes (MLNs) from a total of 68 donors spanning eight decades of life. (nature.com)
- 3 These age- and site-specific pathologies suggest spatial and temporal regulation of intestinal immunity, though in humans, the processes by which immune cell populations interact with and take up residence within the GI tract and gut-associated lymphoid tissues (GALT) are not known. (nature.com)
Tendon1
- The most common options include patellar tendon, hamstring tendon, and donor tissue (allograft). (verywellhealth.com)
Preservation1
- The Qiagen PAXgene non-formalin tissue preservation product was used to stabilize tissue specimens without cross-linking biomolecules. (ucsc.edu)
Semen2
- These guidelines address the use of tests for the hepatitis B and C viruses to screen donations of blood and plasma collected for transfusion or further manufacture into injectable products, as well as to screen donors of organs, tissues, and semen. (cdc.gov)
- It is additionally recommended that blood or serum from donors of organs, tissues, or semen intended for human use be similarly tested and that the test result be used to evaluate the appropriate use of such materials from these donors. (cdc.gov)
Graft survival3
- Information from these studies could lead to the use of donor tissue to manipulate the recipient's immune system in a controlled and specific fashion, thereby increasing graft survival and improving the management of autoimmune diseases. (nih.gov)
- This Request for Applications (RFA), Affecting Graft Survival With Donor Immune Tissue, is related to the priority areas of diabetes and chronic disabling diseases, and immunization and infectious diseases. (nih.gov)
- The study (see NCT00006411 at https://www.clinicaltrials.gov/ ) was designed to compare graft survival rates for corneas from two donor age groups, aged 12-65 and aged 66-75. (nih.gov)
Donate11
- Registering as an organ, eye and tissue donor means you have made the decision to donate your organs, eyes and tissues at the time of your death, with the possibility to save others' lives. (donatelifecolorado.org)
- Donors at least 17 years old (16 with parental consent) and in generally good health may be eligible to donate blood. (biobridgeglobal.org)
- Inspired by 10-year-old Uvalde survivor Mayah Zamora and the 1-year anniversary of the school shooting, superintendents and top administrators from San Antonio and surrounding areas gathered to donate blood at South Texas Blood & Tissue on Tuesday. (biobridgeglobal.org)
- During National Donate Life Month, we honor donors who provide others with a second chance for a healthy life and encourage more Americans to share this precious gift. (greatermkemen.com)
- Visit OrganDonor.gov to learn more about the urgent need for donors and to find resources on how to donate. (greatermkemen.com)
- The Donate Life America Tribute Wall is one way to honor loved ones on National Donor Day. (donatelife.net)
- Can I donate an organ or tissue while I'm still living? (nih.gov)
- Most donations occur after the donor has died, but it is possible to donate certain organs or tissue to someone in need while still living. (nih.gov)
- Unfortunately, the need for organ donors is much greater than the number of people who actually donate. (clevelandclinic.org)
- And if you donate tissues like blood cells, bone or corneas, you can help even more. (nih.gov)
- In addition to organs, you can donate tissues. (nih.gov)
Blood10
- Screening blood donors for HBsAg began in 1969 and became mandatory in 1972. (cdc.gov)
- Type O- is the universal donor, which means it can be given to people with any blood type. (biobridgeglobal.org)
- Every blood center is struggling to maintain a stable blood supply," said Adrienne Mendoza, Chief Operating Officer, South Texas Blood & Tissue. (biobridgeglobal.org)
- Every blood transfusion that is given to a patient in need comes from a volunteer donor, and we are calling on our community to come together. (biobridgeglobal.org)
- Ryan has become a dedicated blood donor-paying it forward for the donations that have saved his daughter's life. (biobridgeglobal.org)
- We are working closely with our hospitals to prepare for scheduled procedures that are likely to require transfusion support," said Dr. Samantha Gomez Ngamsuntikul, Associate Medical Director, South Texas Blood & Tissue. (biobridgeglobal.org)
- Same-day appointments and walk-ins are available at the center's eight donor rooms, as well as at community blood drives. (biobridgeglobal.org)
- I call upon health care professionals, volunteers, educators, government agencies, faith-based and community groups, and private organizations to join forces to boost the number of organ, tissue, blood, and stem cell donors throughout our Nation. (greatermkemen.com)
- The questionnaire is used by most U.S. blood centers to screen potential blood donors. (cdc.gov)
- When you become an organ A system of cells and tissues that perform specific tasks, such as pumping blood (heart), breathing (lungs) or removing waste from the blood (kidney). (nih.gov)
Driver's license1
- You can register to be an organ donor at the time you renew your driver's license or state ID at your local Department of Motor Vehicles. (nih.gov)
Clinical2
- The tissue types collected were chosen based on their clinical significance, logistical feasibility and their relevance to the scientific goal of the project and the research community. (ucsc.edu)
- The donor 's clinical history and cause of death were assessed for secondary analysis . (bvsalud.org)
Human9
- When ICIJ began discussing how to write a story about the untraceable and opaque trade in human tissues, our intent was not to propel readers to toss out their donor cards. (icij.org)
- Many tissue bank executives bring in big salaries, and that might seem to go against the spirit of the law, which expressly outlaws buying and selling human tissue. (icij.org)
- The NIH Genotype-Tissue Expression (GTEx) project was created to establish a sample and data resource for studies on the relationship between genetic variation and gene expression in multiple human tissues. (ucsc.edu)
- Transfusion-associated human T-lymphotropic virus type III/lymphadenopathy-associated virus infection from a seronegative donor--Colorado. (nih.gov)
- Since human cells are especially sensitive, donor livers are stored above freezing at 4 degrees Celsius. (nih.gov)
- Human tissue : ethical and legal issues. (who.int)
- The purpose of this study was to evaluate the prevalence of SARS-CoV-2 in human postmortem ocular tissues of asymptomatic donors and its implications on our eye banking protocols . (bvsalud.org)
- National Donor Day was started in 1998 by the Saturn Corporation and its partner, the United Auto Workers, and is supported by the U.S. Department of Health and Human Services. (donatelife.net)
- This is an actual human valve taken from a donor and implanted in your heart (donor valve implantation). (medicinenet.com)
Urgent need1
- Across our country, we face a shortage of donors and an urgent need for help. (greatermkemen.com)
Individuals2
- These guidelines are intended to serve as a resource to individuals and organizations involved in testing, counselling, and evaluating donors tested for these viruses, and are based on currently available knowledge. (cdc.gov)
- This release is based on data from 17,382 tissue samples obtained from 948 adult post-mortem individuals. (ucsc.edu)
Time1
- In previous studies funded by NIH, Martin Yarmush, Ph.D., director of the Center for Engineering in Medicine, Korkut Uygun, Ph.D., associate professor of surgery, and their collaborators at Massachusetts General Hospital (MGH), Boston, had developed new techniques that extended the time that rat liver (hepatic) tissue can be stored at subzero temperatures without damage. (nih.gov)
Corneal1
- Both the ocular samples that tested positive were conjunctival biopsies (2/100, 2%), whereas corneal samples were negative (0/100, 0%) in both donors . (bvsalud.org)
Grateful1
- But the 26-year-old was grateful his tissues, including skin, corneas, tendons and bones, could still go to people who needed them. (ihtoday.ca)
Register4
- We continue to encourage residents to learn the facts and make an educated, lifesaving decision to register as organ, eye and tissue donors, and to discuss that decision with their families. (donoralliance.org)
- When you register as an organ, eye and tissue donor, your registration remains in effect unless you change it. (donatelifecolorado.org)
- Join us by participating in local events , sharing social media messages and encouraging others to register as donors. (donatelife.net)
- How can someone register to be an organ donor? (nih.gov)
Infection3
- To decrease the potential for disease transmission, donors are screened for risk factors by medical history and for evidence of infection by specific testing. (cdc.gov)
- None of the donors had a medical history suggestive of COVID infection or possible contact. (bvsalud.org)
- Yes, some conditions such as an actively spreading cancer or infection, or heart disease, may prevent a person from becoming a donor. (nih.gov)
People5
- And tissue banks need to be able to attract talented people away from other sectors. (icij.org)
- Experts say that the organs from one donor can save or help as many as 50 people. (medlineplus.gov)
- People of all ages and background can be organ donors. (medlineplus.gov)
- People of all ages should consider themselves potential donors. (clevelandclinic.org)
- donor, you can save the lives of up to 8 people. (nih.gov)
Ultimately1
- This information should ultimately support decisions leading to appropriate tissue donor screening and testing considerations. (nih.gov)
20192
- This track shows median gene expression levels in 52 tissues and 2 cell lines, based on RNA-seq data from the GTEx final data release (V8, August 2019). (ucsc.edu)
- WD 300-380 Connective Tissue Diseases (Note: Several numbers in the WD 300-330 Immune System Related Diseases area had already been cancelled with 2019 summer edition. (nih.gov)
Decision1
- When a Colorado resident registers as a donor, that decision no longer needs to be proactively renewed and will remain in effect unless they change it. (donoralliance.org)
Potential1
- Study objectives were to assess question interpretation, understand potential donors' processes for formulating a response, identify question design problems that could increase inaccurate reports, and compare interpretations between those in different geographic regions. (cdc.gov)
Conjunction1
- Tissue samples were obtained using the GTEx standard operating procedures for informed consent and tissue collection, in conjunction with the National Cancer Institute Biorepositories and Biospecimen . (ucsc.edu)
Skin2
- In Australia, skin can only be donated from deceased donors. (dtbv.org.au)
- Donated skin tissue can be used as grafts for burn victims or for reconstruction after surgery. (nih.gov)
Evidence1
- The scientific goal of the GTEx project required that the donors and their biospecimen present with no evidence of disease. (ucsc.edu)
Lives1
- Organ, eye and tissue donors save lives. (donatelife.net)
Consent2
- Tissue banks overseas have allegedly taken tissue without consent. (icij.org)
- It's a way to legally give consent for the anatomical gift of organs, tissue and eyes. (clevelandclinic.org)
Family3
- After you sign up to be an organ donor, be sure to tell your family and friends. (nih.gov)
- Let your family members and loved ones know you'd like to be a donor. (clevelandclinic.org)
- You might also want to tell your family healthcare provider, lawyer and religious leader that you'd like to be a donor. (clevelandclinic.org)
Consortium1
- Tissue colors were assigned to conform to the GTEx Consortium publication conventions. (ucsc.edu)
Gift of l2
Cells3
- Donor cells can be transferred from one person to another without being rejected. (bernsteinmedical.com)
- Since repeat hair implantations did not provoke the typical rejection responses, even though the donor was of the opposite sex and had a significantly different genetic profile, this indicates that the dermal sheath cells have a special immune status and that the lower hair follicle is one of the body's 'immune privileged' sites. (bernsteinmedical.com)
- In the mucosa, tissue resident memory T cells develop during childhood, and persist in high frequencies into advanced ages, while T cell composition changes with age in GALT and MLN. (nature.com)
Medical6
- The OPO decides if you're a possible donor based on your medical and social history. (nih.gov)
- Do any medical conditions exclude someone from becoming an organ donor? (nih.gov)
- When a person dies, they are evaluated for donor suitability based on their medical history and age. (clevelandclinic.org)
- By becoming an organ donor, does this mean that I wouldn't be eligible to receive the best medical care possible? (clevelandclinic.org)
- The recovery of organs, tissue and eyes is a surgical procedure performed by trained medical professionals. (clevelandclinic.org)
- However, his tissues were rejected when he died last November, said his mother Cindy Gates-Dee, who learned from reading her son's medical records that his "homosexual status," as noted on a screening form by a tissue specialist, meant he was declined as a high-risk donor because he'd had sex with another man in the last five years. (ihtoday.ca)
Bank1
- Donor corneas were provided by 43 eye banks, and met the quality standards of the Eye Bank Association of America. (nih.gov)