Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.
Pathological processes consisting of the union of the opposing surfaces of a wound.
Adherence of cells to surfaces or to other cells.
Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
An anchoring junction of the cell to a non-cellular substrate. It is composed of a specialized area of the plasma membrane where bundles of the ACTIN CYTOSKELETON terminate and attach to the transmembrane linkers, INTEGRINS, which in turn attach through their extracellular domains to EXTRACELLULAR MATRIX PROTEINS.
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
A family of non-receptor, PROLINE-rich protein-tyrosine kinases.
A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.
Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)
Self-replicating, short, fibrous, rod-shaped organelles. Each centriole is a short cylinder containing nine pairs of peripheral microtubules, arranged so as to form the wall of the cylinder.
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.
The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.
Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
A property of the surface of an object that makes it stick to another surface.
A cytoskeletal protein associated with cell-cell and cell-matrix interactions. The amino acid sequence of human vinculin has been determined. The protein consists of 1066 amino acid residues and its gene has been assigned to chromosome 10.
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Cell adhesion molecule and CD antigen that mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells.
The phenomenon by which dissociated cells intermixed in vitro tend to group themselves with cells of their own type.
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Cell surface receptors that bind to and internalize SECRETED PHOSPHOLIPASES A2. Although primarily acting as scavenger receptors, these proteins may also play a role in intracellular signaling. Soluble forms of phospholipase A2 receptors occur through the action of proteases and may a play a role in the inhibition of extracellular phospholipase activity.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
The physiological renewal, repair, or replacement of tissue.
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC
A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.
A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A cell-separation technique where magnetizable microspheres or beads are first coated with monoclonal antibody, allowed to search and bind to target cells, and are then selectively removed when passed through a magnetic field. Among other applications, the technique is commonly used to remove tumor cells from the marrow (BONE MARROW PURGING) of patients who are to undergo autologous bone marrow transplantation.
A 60-kDa extracellular protein of Streptomyces avidinii with four high-affinity biotin binding sites. Unlike AVIDIN, streptavidin has a near neutral isoelectric point and is free of carbohydrate side chains.
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.

Evaluation of the performance of fertiloscopy in 160 consecutive infertile patients with no obvious pathology. (1/635)

We have defined fertiloscopy as the combination in one investigation of transvaginal hydropelviscopy, dye-test, optional salpingoscopy, and hysteroscopy, performed on an outpatient basis under local anaesthesia or neuroleptanalgesia. We have applied this approach in a routine manner to 160 infertile patients with no obvious pathology. Fertiloscopy was achieved in 154 patients (96.2%). In five patients visualization was not satisfactory because of technical problem or adhesions in the pouch of Douglas. We had one (0.6%) rectal injury, which was treated conservatively. Sixty patients (37.5%) had normal fertiloscopic examination. Endometriosis was discovered in 21 patients (13.1%) post-pelvic inflammatory disease (PID) lesions in 58 cases (36.2%), and subtle abnormalities in 15 cases (9.3%). Salpingoscopy was completed when post-PID lesions were encountered. In 39% of cases only partial examination was possible because of external tubal adhesions, but it was nevertheless sufficient to obtain a good view of the first one-third of the ampulla. In all, 74 patients (46.2%) were referred directly to in-vitro fertilization (IVF) procedures, and so avoided a further laparoscopy. Quality of imaging, accuracy of the pelvic examination in a physiological manner, and safety of the procedure are the main advantages of this minimally invasive technique. Selection of the patients for surgery is therefore enhanced, and indication for IVF is better balanced, avoiding the performance of extensive procedures in patients who should thus benefit from this less traumatic alternative.  (+info)

Hysteroscopic treatment of severe Asherman's syndrome and subsequent fertility. (2/635)

In a retrospective case report series, we evaluated the efficacy of hysteroscopic adhesiolysis in patients with severe Asherman's syndrome. In 31 patients with permanent severe adhesions, hysteroscopic treatment was performed. In all patients, uterine cavity with at least one free ostial area was restored after one (n = 16), two (n = 7), three (n = 7), and four (n = 1) surgical procedures. All previously amenorrhoeic patients (n = 16) had resumption of menses. Twenty-eight patients were followed-up with a mean time of 31 months (range 2-84). Fifteen pregnancies were obtained in 12 patients and the outcomes were the following: two first trimester missed abortions, three second trimester fetal losses, one second trimester termination of pregnancy for multiple fetal abnormalities and nine live births in nine different patients. Pregnancy rate after treatment was 12/28 (42.8%) and live birth rate was 9/28 (32.1%). In patients 35 years (P = 0. 01). Three patients were lost to follow-up and their results omitted. In nine patients with live births, one Caesarean hysterectomy for placenta accreta and one hypogastric arteries ligation for severe haemorrhage and placenta accreta were performed. Hysteroscopic treatment of severe Asherman's syndrome appeared to be effective for the reconstruction of a functional uterine cavity with a 42.8% pregnancy rate. However, these pregnancies were at risk for haemorrhage with abnormal placentation.  (+info)

Expanded polytetrafluoroethylene membrane for the prevention of peridural fibrosis after spinal surgery: an experimental study. (3/635)

One of the most common complications of lumbar spine surgery is peridural fibrosis, a fibroblastic invasion of the nerve roots and the peridural sac exposed at operation. Peridural fibrosis may produce symptoms similar to those the patient experienced preoperatively and, if another spinal operation is necessary, may increase the risk of injury at reexposure. In a controlled study in dogs, we assessed the use of expanded polytetrafluoroethylene (ePTFE) as a barrier to postoperative invasion of fibrous tissue into the laminectomy defect. In 14 dogs, a two-level laminectomy was done, at L4-L5 and L6-L7. In 12 dogs, an ePTFE membrane was placed directly over the dorsal surface of the laminectomy defect at L4-L5 and within the defect (over the surface of the dura) at L6-L7. No material was implanted in two dogs (controls). Tissue for histologic studies was obtained from the controls and from ten dogs with the membrane 12 weeks postoperatively. Two dogs with the membrane underwent reoperation. The study found that there was no peridural fibrosis in seven of the ten specimens in which the ePTFE membrane had been placed directly on the dorsal surface of the laminectomy defect, some peridural fibrosis in all specimens in which the membrane had been placed within the defect, and extensive fibrosis in controls. The ePTFE membrane created an excellent plane of dissection for reoperation. No foreign-body reactions to the membrane or membrane-related infections occurred. We conclude that the ePTFE spinal membrane, when properly implanted, is an effective barrier to postsurgical fibrous invasion of the vertebral canal. Clinical studies of use of this material in spinal surgery are warranted.  (+info)

Expanded polytetrafluoroethylene membrane for the prevention of peridural fibrosis after spinal surgery: a clinical study. (4/635)

Peridural fibrosis developing after laminectomy may cause pain that can necessitate reoperation. Many materials have been used as a barrier to invasion of fibrous tissue into the vertebral canal, but the ideal material has not been found. Various studies in animals have achieved favourable results with an expanded polytetrafluoroethylene (ePTFE) membrane. In a prospective, randomized study, we compared postoperative results in 33 patients who had an ePTFE membrane implanted to cover the defect caused by laminectomy during lumbar spine decompression with the results in 33 patients in whom no material was implanted. At operation, an ePTFE membrane was placed after the decompression procedure to cover the laminectomy defect completely. Systematic clinical and MRI follow-up evaluations of patients with and without the membrane were conducted 3, 6, 12, and 24 months postoperatively. The effect of ePTFE membrane implantation over laminectomy sites on postoperative peridural fibrosis, pain and neurological claudication was assessed. The ePTFE-membrane group had a significantly lower rate of epidural fibrosis on MRI (P<0.0001) and of clinical manifestations of radiculalgia (P = 0.002) compared with the no-material group. Epidural fibrosis that occurred in the ePTFE group was generally less extensive than that in the no-material group. There was no significant difference in the rate of postoperative claudication in the two groups. Significantly more seromas occurred in the ePTFE group (P = 0.0002). There were no infections or other complications in either group. The results showed that placement of an ePTFE spinal membrane over the laminectomy defect produced by lumbar spine surgery provided a physical barrier to invasion of fibrous tissue into the vertebral canal, and patients with the membrane had less postoperative radicular pain.  (+info)

Adhesion preventive effect of hyaluronic acid after intraperitoneal surgery in mice. (5/635)

Prevention of intraperitoneal adhesion after gynaecological surgery is essential for maintaining postoperative fertility. In this study, the adhesion prevention effect was examined of a hyaluronic acid (HA) solution obtained from the fermentation method and having a molecular weight of 1.9x10(6) with high viscosity. Laparotomy was conducted on female mice 7 weeks old, whose menstrual periods were synchronized by pregnant mare serum gonadotrophin (PMSG) to injure the uterine horn surface. Intraperitoneal adhesions were favourably formed in 91.7% of cases induced with iodine abrasion, compared with 50% induced by electrosurgery. Intraperitoneal administration of HA was evaluated for its effect on the prevention of adhesions made by iodine abrasion. Adhesion prevention effects of HA were observed at concentrations of 0.3, 0.5, 0.75 and 1.0%, among which the most pronounced effect was with the use of a 0.3% solution (92.3% of cases). Compared with the control group adhesion score of 2.0 +/- 0. 8, significant decreases in adhesion scores were observed at all concentrations. HA with a molecular weight of 1.9x10(6) was recognized to have a definitive prevention effect on postoperative adhesions in mice after laparotomy and is considered to be a prospective material for future clinical use.  (+info)

Nitric oxide modulation of focal adhesions in endothelial cells. (6/635)

A permissive role of nitric oxide (NO) in endothelial cell migration and angiogenesis promoted by vascular endothelial growth factor (VEGF), endothelin, and substance P has previously been established. The present studies were designed to examine the mechanism(s) involved in the NO effect on focal adhesions. Time-lapse videomicroscopy of human umbilical vein endothelial cells (HUVECs) plated on the silicone rubber substrate revealed that unstimulated cells were constantly remodeling the wrinkling pattern, indicative of changing tractional forces. Application of NO donors reversibly decreased the degree of wrinkling, consistent with the release of tractional forces exerted by focal adhesions and stress fibers. Morphometric and immunocytochemical analyses showed that NO inhibited adhesion and spreading of HUVECs and attenuated recruitment of paxillin to focal adhesions. NO also had a profound dose-dependent effect on the formation of stress fibers by HUVECs. De novo formation of focal adhesions in HUVECs was significantly diminished in the presence of NO donors. Migration of HUVECs showed an absolute requirement for the functional NO synthase. NO donors did not interfere with focal adhesion kinase recruitment to focal adhesions but affected the state of its tyrosine phosphorylation, as judged from the results of immunoprecipitation and immunoblotting experiments. Videomicroscopy of HUVECs presented with VEGF in a micropipette showed that the rate of cell migration was slowed down by NO synthase inhibition as well as by inhibition of tyrosine phosphorylation. Collectively, these data indicate that NO reversibly releases tractional forces exerted by spreading endothelial cells via interference with the de novo formation of focal adhesions, tyrosine phosphorylation of components of focal adhesion complexes, and assembly of stress fibers.  (+info)

How long does laparoscopic surgery really take? Lessons learned from 1000 operative laparoscopies. (7/635)

The purpose of this study was to assess the operating time of the most common gynaecological laparoscopic procedures. We analysed retrospectively 1000 consecutive operative laparoscopies on a procedure-by-procedure basis. Diagnostic laparoscopy and laparoscopic sterilization were specifically excluded from the analysis. The various laparoscopic procedures were grouped and analysed under six major categories. The average operating time for all cases was 76.9 min (range 10-400). In 38 cases (3.8%) the laparoscopic procedure was converted to laparotomy. The average operating time for treating ectopic pregnancy and tubal disease was approximately 60 min (range 13-240). Surgery for endometriosis and ovarian cysts averaged 72 min (range 10-240). Laparoscopic myomectomy and hysterectomy averaged 113 and 131 min respectively (range 25-400). Our results show that while the operating time for most operative laparoscopies is less than 75 min, the range of operating times is great. The relative lack of predictability in procedure times means that the efficient utilization of fixed theatre sessions is difficult.  (+info)

The role of neutrophils in the formation of peritoneal adhesions. (8/635)

The most common cause of intraperitoneal adhesions which may result in infertility and intestinal obstruction is previous abdominal surgery. Surgical trauma of the peritoneum in the absence of infection elicits a rapid and transient influx of polymorphonuclear leukocytes (PMN) into the peritoneal cavity. The role of neutrophils in intraperitoneal adhesion formation has not been studied. We aimed to study the effects of PMN counts and PMN functions on peritoneal adhesion formation. Forty peritoneal adhesion-induced rats were randomly divided into three groups; group I, receiving saline; group II, receiving cyclophosphamide; and group III, receiving granulocyte-macrophage colony-stimulating factor (GM-CSF). In all groups, peritoneal lavage was performed to determine PMN counts the day after adhesion induction. Blood neutrophil counts and neutrophil functions were also determined. Adhesions were evaluated blindly 14 days after the operation. Adhesion tissue samples were microscopically evaluated. Tissue hydroxyproline and collagen concentrations were measured. The neutrophil counts and phagocytosis significantly increased in group III and neutrophil counts decreased in group II (P < 0.05). The score of adhesion formation in group II was significantly less than that in groups I and III (P < 0.05). Hydroxyproline concentrations of adhesion tissue were significantly decreased in group II when compared with group III (P < 0.05). The present study shows that neutropenia lowers the degree of postoperative adhesion formation. It is concluded that PMN may have a role to play in modulating post-operative adhesion formation.  (+info)

Adhesion barriers have proven to reduce adhesion-related complications in colorectal surgery. However, barriers are seldom applied. The aim of this study was to determine the cost-effectiveness of adhesion barriers in colorectal surgery. A decision-tree model was developed to compare cost-effectiveness of no adhesion barrier with the use of an adhesion barrier in open and laparoscopic surgery. Outcomes were incidence of clinical consequences of adhesions, direct healthcare costs, and incremental cost-effectiveness ratio per adhesion prevented. Deterministic and probabilistic sensitivity analyses were performed. Adhesion barriers reduce adhesion incidence and incidence of adhesive small bowel obstruction in open and laparoscopic surgery. Adhesion barriers in open surgery reduce costs compared to no adhesion barrier ($4376 versus $4482). Using an adhesion barrier in laparoscopic procedures increases costs by $162 ($4482 versus $4320). The ICER in the laparoscopic cohort was $123. Probabilistic sensitivity
Peritoneal adhesions occur in up to 93% of adults after peritoneal trauma during surgery. Most adhesions are asymptomatic but can cause female infertility, small bowel obstruction (SBO) and chronic abdominal pain. Adhesion prophylaxis is needed to reduce the significant morbidity and increased health care costs resulting from peritoneal adhesions. This thesis aims to establish a relevant and reproducible experimental adhesion model to simultaneously study the healing processs and adhesion formation and later to examine whether carbazate-activated polyvinyl alcohol (PVAC), an aldehyde-carbonyl scavenger, can reduce adhesion formation or not; and, in a long-term follow-up, to investigate the incidence of and identify risk factors for adhesive SBO requiring surgical treatment after laparotomy during infancy and to survey the prevalence of self-reported chronic abdominal pain and female infertility. Male Sprague-Dawley rats were subjected to laparotomy, cecal abrasion, and construction of a small ...
Inhibition of cyclooxygenase-2 prevents intra-abdominal adhesions by decreasing activity of peritoneal fibroblasts Guangbing Wei,1 Xin Chen,2 Guanghui Wang,1 Pengbo Jia,1,3 Qinhong Xu,2 Gaofeng Ping,1 Kang Wang,1 Xuqi Li1 1Department of General Surgery, 2Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, 3Department of General Surgery, First People’s Hospital of Xianyang City, Xianyang, People’s Republic of China Background: Postoperative intra-abdominal adhesions are common complications after abdominal surgery. The exact molecular mechanisms that are responsible for these complications remain unclear, and there are no effective methods for preventing adhesion formation or reformation. The aim of the study reported here was to investigate the preventive effects and underlying potential molecular mechanisms of selective cyclooxygenase-2 (COX-2) inhibitors in a rodent model of postoperative intra-abdominal
Intra-abdominal adhesions following abdominal surgery represent a major unsolved problem. They are the first cause of small bowel obstruction. Diagnosis is based on clinical evaluation, water-soluble contrast follow-through and computed tomography scan. For patients presenting no signs of strangulation, peritonitis or severe intestinal impairment there is good evidence to support non-operative management. Open surgery is the preferred method for the surgical treatment of adhesive small bowel obstruction, in case of suspected strangulation or after failed conservative management, but laparoscopy is gaining widespread acceptance especially in selected group of patients. Good surgical technique and anti-adhesive barriers are the main current concepts of adhesion prevention. We discuss current knowledge in modern diagnosis and evolving strategies for management and prevention that are leading to stratified care for patients ...
Looking for abdominal adhesion? Find out information about abdominal adhesion. 1. an attraction or repulsion between the molecules of unlike substances in contact: distinguished from cohesion 2. Pathol abnormal union of structures or... Explanation of abdominal adhesion
Tendon adhesions are one of the most concerning complications after surgical repair of flexor tendon injury. Extracellular signal-regulated kinase (ERK) 2 plays crucial roles in fibroblast proliferation and collagen expression which contributes to the formation of tendon adhesions after flexor tendon surgery. Using a chicken model, we have examined the effects of a small interfering RNA (siRNA) targeting ERK2 delivered by a lentiviral system on tendon adhesion formation with an adhesion scoring system, histological assessment, and biomechanical evaluation. It was found that ERK2 siRNA effectively suppressed the increase of fibroblasts and the formation of tendon adhesions (p < 0.05 compared with the control group). Moreover, no statistically significant reduction in breaking force was detected between the ERK2 siRNA group and the control group. These results show that the lentiviral-mediated siRNA system is effective in preventing tendon adhesion formation but not to tendon healing, and may be used
Definition : Solutions designed to act as a temporary barrier inhibiting postsurgical adhesion between tissues and organs. These solutions are applied to the surface of tissues and organs at the end of surgery, before surgical closure, and are typically resorbed by the body in a short period (e.g., several days). Postsurgical adhesion inhibition solutions are intended for use in pelvic and gynecological surgery, both in open and laparoscopic procedures.. Related Terms : Films, Postsurgical Adhesion Inhibition , Gel, Postsurgical Adhesion Inhibition. Entry Terms : Surgical Adhesion Barrier Solutions , Adhesion Inhibition Solutions , Adhesion Barrier Solutions , Scarring Inhibitors , Postsurgical Scarring Inhibitors , Barriers, Adhesion, Resorbable. UMDC code : 20374 ...
Atıf İçin Kopyala Pata Ö. , Yazici G., Apa D., Tok E., Oz U., Kaplanoğlu M., et al. European journal of obstetrics, gynecology, and reproductive biology, cilt.117, ss.64-9, 2004 (SCI İndekslerine Giren Dergi) ...
Atıf İçin Kopyala OZDEN A., BOSTANCI B., SARIOGLU A., Taşkiran D. , TETIK C. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, cilt.31, ss.465-70, 1999 (SCI Expanded İndekslerine Giren Dergi) ...
Vagal enhancement through electroacupuncture at St 36 prevents post op adhesions by A ST36 significantly decreased angiogenesis evidenced by reduced CD31
A process and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to the peritoneal or pleural cavity or organs situated therein. Both aqueous and non-aqueous compositions comprising a polyoxyalkylene block copolymer are applied to injured areas of the peritoneal or pleural cavity or organs situated therein subsequent to surgical injury.
Peritoneal adhesion formation is a common consequence of any operation or intra-abdominal inflammatory process (eg, pelvic inflammatory disease [PID], diverticulitis, spontaneous bacterial peritonitis). It is estimated that intra-abdominal adhesions develop in 90-95% of patients after surgery.
Official title:. Sensitivity and predictive value of functional cine magnetic resonance imaging (MRI) detecting intra-abdominal adhesions. Background:. Adhesions are a frequent problem in abdominal surgery. The formation of adhesions is part of a normal wound healing. However in some patients adhesions cause severe complications such as chronic pain, obstruction and strangulation of the bowel. Adhesions can also obstruct access to the peritoneal cavity and complicate reoperations. Accurate imaging of adhesions would be of benefit avoiding adhesion related complications at repeated laparotomy or laparoscopy. At present no validated diagnostic tool mapping adhesions exists.. Purpose:. To define the sensitivity and specificity of functional cineMRI in detecting and mapping adhesions in patients undergoing reoperation.. Design:. Prospective multicenter observational trial. Primary outcome:. Sensitivity and specificity of functional MRI detecting adhesions to the abdominal wall. Secondary ...
Background Postoperative adhesions constitute a substantial clinical problem at hand surgery. for PXL01 placebo group, p?=?0.016 in PPAS). The percentage of sufferers with exceptional/great digit mobility was higher in the PXL01 group (61% 38%, p?=?0.0499 in PPAS). Regularly, the PXL01 group provided improved tip-to-crease length (5.0 15.5 mm for PXL01 placebo group, p?=?0.048 in PPAS). Sensory evaluation demonstrated that more sufferers in the PXL01 group sensed the thinnest monofilaments (FAS: 74% 35%, p?=?0.021; PPAS: 76% 35%, p?=?0.016). At a year post-surgery, more sufferers in the placebo group had been considered to reap the benefits of tenolysis (30% 12%, p?=?0.086 in PPAS). The procedure was secure, well tolerated, and didnt increase the price of tendon rupture. Conclusions Treatment with PXL01 in sodium hyaluronate increases hands recovery after flexor tendon fix surgery. Additional scientific trials are warranted to look for Vilazodone the many effective health insurance and dose ...
Adhesions treatment with laparoscopic adhesiolysis (costs for program #152699) ✔ University Hospital Tubingen ✔ Department of General, Abdominal and Transplant Surgery ✔
Abdominal adhesions can kink, twist, or pull the intestines out of place, causing an intestinal obstruction. An intestinal obstruction partially or complete
BACKGROUND: Intra-abdominal adhesions constitute between 49% and 74% of the causes of small bowel obstruction. Traditionally, laparotomy and open adhesiolysis have been the treatment for patients who have failed conservative measures or when clinical and physiologic derangements suggest toxemia and/or ischemia. With the increased popularity of laparoscopy, recent promising reports indicate the feasibility and potential superiority of the minimally invasive approach to the adhesion-encased abdomen. METHODS: The purpose of this study was to assess the outcome of laparoscopic adhesiolysis and to provide technical tips that help in the success of this technique. RESULTS: The most important predictive factor of adhesion formation is a history of previous abdominal surgery ranging from 67%-93% in the literature. Conversely, 31% of scars from previous surgery have been free of adhesions, whereas up to 10% of patients without any prior surgical scars will have spontaneous adhesions of the bowel or ...
PURPOSE: Tissue adhesion is a well-known postsurgical phenomenon, causing pain, functional obstruction, and difficult reoperative surgery. To overcome these problems, various synthetic and natural polymer membranes have been developed as postoperative tissue adhesion barriers. However, limitation in their use has hindered its actual application. We prepared a hyaluronate membrane (HM) to evaluate its efficacy and safety as an adhesion barrier compared to a commercialized product (Interceed, Ethicon). METHODS: To evaluate the antiadhesion effect, a cecum-abdominal wall abrasion model was adopted in a rabbit. The denuded cecum was covered by Interceed or HM or neither and apposed to the abdominal wall (each, n = 10). Four weeks after surgery, the level of adhesion was graded. Acute and chronic toxicity of the three groups were also evaluated. RESULTS: Blood samples drawn to evaluate acute toxicity at postoperative day 3 and 7 showed no significant difference among the three groups. The grade and ...
Peritoneal adhesions | Surgical adhesiolysis. Surgery: Treatment in Heidelberg, Germany ✈. Prices on - booking treatment online!
In the first epidemiologic study of its kind, investigators in the Surgical and Clinical Adhesions Research (SCAR) study have shown that postoperative adhesions are directly related to a substantial number of hospital readmissions and result in a high rate of complications with potentially significant long-term consequences. Reporting in a recent issue of the Lancet, Ellis and associates urge that greater emphasis be placed on identifying surgical procedures with a high risk of adhesion-related complications and on assessing proposed adhesion prevention strategies.. Using the Scottish National Health Service medical record linkage database, the SCAR investigators identified 29,790 patients who underwent open abdominal or pelvic surgery in 1986 and had not had similar surgery in the previous 5 years. Over 10 years follow-up, one in three (34.6%) of these patients was readmitted because of a disorder directly or possibly related to adhesions or for abdominal or pelvic surgery that could ...
Severity of adhesions at seven predefined sites (pericardial or retrosternal, inferior or diaphragmatic region, right lateral or arterial region, region around great vessels). Severity of adhesions is graded as 0 = no adhesions, 1 = filmy and avascular, 2 = requiring blunt dissection, 3 = requiring sharp dissection, 4 = requiring extensive sharp dissection. Adhesion scores for each patient will be derived from the sum of adhesion severity scores at each site, from 0 (no adhesions) to 28 (cohesive adhesions at all sites ...
TY - JOUR. T1 - Adenovirus-mediated expression of cyclooxygenase-2 antisense reverse abnormal genetic profile of human adhesion fibroblasts. AU - Saed, Ghassan M.. AU - Al-Hendy, Ayman. AU - Salama, Salama A.. AU - Diamond, Michael P.. PY - 2008/5/1. Y1 - 2008/5/1. N2 - Objective: To determine the effects of blocking the translation of cyclooxygenase-2 (COX-2) mRNA on the mRNA levels of type I collagen, type III collagen, fibronectin, and transforming growth factor-beta (TGF-β1) in fibroblasts obtained from normal peritoneal and adhesion tissues. Design: Prospective experimental study. Setting: University medical center. Patient(s): Fibroblasts established from peritoneal and adhesion tissue of the same patients. Intervention(s): Adenovirus with COX-2 treatment of the primary cultured fibroblasts. Main Outcome Measure(s): Fibroblasts of normal peritoneal and adhesion tissues were isolated from the same patients. Adhesion and normal peritoneal fibroblasts were transfected with an adenovirus ...
The number of biologicals for the therapy of immunologically mediated diseases is constantly growing. In contrast to other agents that were previously introduced in rheumatologic or dermatologic diseases and only later adopted for the treatment of inflammatory bowel diseases (IBDs), the field of IBD was ground breaking for the concept of anti-adhesion blockade. Anti-adhesion antibodies selectively target integrins controlling cell homing to the intestine, which leads to reduction of inflammatory infiltration to the gut in chronic intestinal inflammation. Currently, the anti-α4β7-antibody vedolizumab is successfully used for both Crohns disease and ulcerative colitis worldwide. In this mini-review, we will summarize the fundamental basis of intestinal T cell homing and explain the molecular groundwork underlying current and potential future anti-adhesion therapies. Finally, we will comment on noteworthy clinical aspects of anti-adhesion therapy and give an outlook to the future of anti-integrin
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Intestinal adhesion after abdominal surgery is a continuous state of fibrosis and inflammation that concomitantly facilitates the progression of a variety of complications, such as chronic abdominopelvic discomfort, pain, and infertility. Berberine has recently become a useful anti-inflammatory drug for cardiovascular, endocrine, and intestinal disorders, because of its antitumor and antilipase effects (Jeong et al., 2009; Jiang et al., 2011; Meng et al., 2012; Yao et al., 2013). Here, we identified berberine as an antiadhesion agent that effectively protects against postabdominal surgery adhesion and inflammation, with several lines of evidence including reduced adhesion scores from direct assessment of adhesions, histopathology measurement of lymphocytes and vascular proliferation, decreased circulating concentration of ICAM-1, downregulated expression levels and secretion of various proinflammatory cytokines in both serum and cecum, and suppression of TAK1, JNK, and NF-κB signaling.. ICAM-1 ...
After the last procedure in October 2010 the patient had 17 month without surgeries with partially better periods, but was till not fit to start daily activities and start working.February 2012 and October 2012 ADHESIOLYSIS #4 and #5 were performed, cleaning the left and right side of her entire abdomen and a huge amount of interluminal adhesions at her bowel.. Although the pain got better, she experienced periods of nausea and vomiting, so we decided together to go to the last part of her abdomen, to the pelvic areas, where small bowel was adherent to the uterus.. In February 2013 we perfomed ADHESIOLYSIS #6 with an excellent result for the pelvic organs and the bowel adhesions. Only few interluminal adhesions without constrictions were left, as the risk of a bowel perforation was too high.Please check the text under the images!. NOTE: This patient had all together 6 sets of adhesiolysis surgery with a 2nd look, unfortunately at Adhesiolysis #2 there was an infection that had to be cleared with ...
Adhesions are bands of scar tissue that form between organs. In the abdomen, they form after an abdominal surgery or after a bout of intraabdominal infection (ie, pelvic inflammatory disease, diverticulitis).
In the end, relieving your pain (whether it is from adhesions, scar tissue, or overly tight abdominal or pelvic muscles) is going to be about healing your whole Self. The tools I offer on this site in the form of the various programs will hopefully help you on your journey and I hope that as you move through this process you find it all useful.. DA: 30 PA: 12 MOZ Rank: 42 ...
Tyrosine phosphorylation is implicated in the formation, maintenance and turnover of cell-matrix adhesions (Barry and Critchley, 1994; Ridley and Hall, 1994; Chrzanowska-Wodnicka and Burridge, 1994; Bershadsky et al., 1996; Retta et al., 1996; Ayalon and Geiger, 1997; Schneider et al., 1998), yet the mechanism underlying this involvement is still obscure. In this study, we addressed this issue by comparing local changes in PY levels to the recruitment of several FA proteins induced by the microtubule-disrupting drug nocodazole. For this purpose, we have combined quantitative immunofluorescence microscopy with a novel approach for monitoring kinetics of tyrosine phosphorylation in live cells.. FA assembly is a multistage process that involves the transformation of small, dot-like focal complexes into large FAs (see Geiger et al., 2001). Previous studies have shown that application of mechanical force to focal complexes, either by increasing cytoskeletal contractility or by external perturbation, ...
When I look back on why (Feeling sorry for myself..... It happens to all of us to some extent). I know Im hardwired in my brain to go,go,go. Like the energizer bunny my brain doesnt stop when my body says Quit!!!! Im no doctor, but Im more than happy (Sarcasm), As painfully proven to write my own prescription for those years with liquor, etc. It unwound me and Id pass out (sleep peacefully), for a few hours and Good time Ziff was ready for 10-12 hours or longer iron work. No harm, no fowl, Alcohol is legal and consumption at work wasnt needed as long as I got my reward eventually for that days wage and I bullheadedly demanded that over everything. Hindsights a BIT_H aint it. I can only improve or die. I know better and lesson with addiction well learned. I somewhat enjoy lifes aspects as oppose to death. Future aint bright in a hole. Move on it must be then ...
OBJECTIVE: To estimate the diagnostic value of transvaginal ultrasonography in the detection of pelvic adhesions in women suspected of having endometriomas at ultrasonography. DESIGN: Prospective observational study. SETTING: Academic Department of Obstetrics and Gynecology. PATIENT(S): One hundred thirteen women who underwent surgery for an endometrioma. INTERVENTION(S): All patients underwent transvaginal ultrasonography before surgery, and at ultrasonography the presence of fixation of the ovary to the uterus was considered characteristic of the presence of pelvic adhesions. MAIN OUTCOME MEASURE(S): Sensitivity, specificity, and likelihood ratios were calculated with 95% confidence intervals (CIs). RESULT(S): The sensitivity and specificity of the fixation to the uterus of at least one ovary were respectively 89% (95% CI 84%-92%) and 90% (95% CI 76%-97%). The likelihood ratio for fixation of at least one ovary to the uterus was 8.92 (95% CI 3.04-26) and for a normal ultrasound examination ...
stated that a second operation is not an option because of adhesions. questions: ... specialist who confirms a relapse with presence of adhesions and impossibility of another surgical operation. The doctor, then, .... ...
The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition preferably comprising chain extended, coupled or crosslinked polyester/poly(oxyalkylene) ABA triblocks or AB diblocks having favorable EO/LA ratios to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.
Adhesiolysis in Delhi. Cost of Adhesiolysis in Delhi, View List of Best Reviewed Hospitals & Surgeons & Book Appointment, Patient Reviews, Adhesiolysis Meaning, Risks, Side Effects & FAQ. | Practo
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One cause of GI issues- including SIBO- is abdominal adhesions, also known as ARD which stands for Adhesion Related Disorders. There can be many causes of adhesions- inflammation, endometriosis (which is very underdiagnosed), radiation treatments, surgery, injuries, auto accidents, burst ovarian cysts, to name some. I suspect that a certain % of IBS and SIBO patients actually have ARD but dont, and may never, know it. Adhesions do not show up on imaging tests. I have heard about a test is Europe, called a Functional Cine MRI, as being possibly able to diagnose them, but have never heard of it being used for this purpose in the US, except for imaging the brain.. In any case, even if you are pretty certain that you are affected by abdominal and/or pelvic adhesions, you are not likely to find any help from them. Drs do not like to talk about adhesions- supposedly, because the only way to definitively diagnose them is via exploratory laparoscopy, which they are reluctant to do, and insurance ...
Mucin 16 (MUC16) is a type I transmembrane protein, the extracellular portion of which is shed after proteolytic degradation and is denoted as CA125 antigen, a well known tumor marker for ovarian cancer. Regarding its polypeptide and glycan structures, as yet there is no detailed insight into their heterogeneity and ligand properties, which may greatly influence its function and biomarker potential. This study was aimed at obtaining further insight into the biological capacity of MUC16/CA125, using in silico analysis of corresponding mucin sequences, including similarity searches as well as GO (gene ontology)-based function prediction. The results obtained pointed to the similarities within extracellular serine/threonine rich regions of MUC16 to sequences of proteins expressed in evolutionary distant taxa, all having in common an annotated role in adhesion-related processes. Specifically, a homology to conserved domains from the family of herpesvirus major outer envelope protein (BLLF1) was found. In
MRI may provide useful information for preoperative planning relating to pelvic adhesions, according to a multidisciplinary team of radiologists and gynecolo...
What is 4DryField® PH?. 4DryField® PH is an innovative medical device for adhesion prevention and haemostasis that can be used in a wide range of surgical indications. Due to its physical properties, 4DryField® PH absorbs many times its own mass in liquid within a few seconds.. 4DryField® PH is made up of sterile hydrophilic microparticles. These are manufactured from highly purified potato starch in a complex process. 4DryField® PH contains no components whatsoever of animal or human origin. It is biocompatible, pyrogen-free, and hypoallergenic. Therefore, 4DryField® PH meets the stringent requirements for a Class III medical device. There are no known side effects up to now. Occasionally, there may be a temporary increase in CRP with no leukocytosis and no increase in temperature.. If you have any questions on 4DryField® PH, you would like to discover new areas of application, or youd like to share your experiences with 4DryField® PH, please feel free to contact us.. You can find ...
An implantable prosthesis and a method of repairing an anatomical defect, such as a tissue or muscle wall defect, by promoting tissue growth thereto, while limiting the incidence of postoperative adhesions between a portion of the prosthesis and tissue or organs. The prosthesis is formed of a biologically compatible, flexible layer of repair fabric suitable for reinforcing tissue or muscle and closing anatomical defects, and a barrier layer for physically isolating at least a portion of one side of the fabric from areas likely to form adhesions. A peripheral barrier extends about at least a portion of the outer peripheral edge of the repair fabric to inhibit adhesions between the outer peripheral edge and adjacent tissue and organs. The repair fabric may include an outer margin that has been melted and resolidified to render the outer peripheral edge substantially impervious to tissue ingrowth. The barrier layer may be joined to the repair fabric with connecting stitches formed from PTFE to inhibit the
Indicated therapies: aftercare following bone or joint operations, chronic gastro-enteritis, the inactive stages of chronic, inflammatory locomotor disorders (eg. rheumatoid arthritis, articular diseases, Bechterew-disease), chronic, inflammatory gynaecological diseases, chronic neuritis, nervous pains, the inactive stages of chronic degenerative bone and joint diseases,, chronic constipation, muscle rheumatism, adhesions following gynaecological operations, osteoporosis (calcium deficiency of the bones ...
Despite improvements in surgery and treatment of ovarian cancer, the long-term survival of patients with this disease is limited due to the intraperitoneal (i.p.) spread of tumor cells from the primary tumor mass. A crucial step in the establishment of secondary foci is the adherence of disseminated tumor cells to the mesothelial surfaces of the peritoneum. Thus, a potentially efficacious adjuvant therapy approach could involve the i.p. administration of agents that target tumor cell and mesothelial cell interactions. To better understand the pivotal processes, we developed an in vitro cell adhesion model in order to identify key molecules and to test their effect on phenotype. Findings from the model were subsequently confirmed in human tissue specimens.. By conditioning FOC3 cells through immune-compromised mice [12, 13] we derived the MFOC3 sub-line by recovery from an advanced FOC3 xenograft tumor formed in SCID mice. Unlike FOC3 cells, inoculation of the MFOC3 subline resulted in multiple ...
We discuss microscopic and continuum cell-cell adhesion models and their derivation based on the underlying microscopic assumptions. We analyse the behavior of these models at the microscopic level based on the concept of H-stability of the interaction potential. We will derive these macroscopic limits via mean-field assumptions. We propose an improvement on these models leading to sharp fronts and intermingling invasion fronts between different cell type populations. The model is based on basic principles of localized repulsion and nonlocal attraction due to adhesion forces at the microscopic level. The new model is able to capture both qualitatively and quantitatively experiments by Katsunuma et al. (2016) [J. Cell Biol. 212(5), pp. 561-575]. We also review some of the applications of these models in other areas of tissue growth in developmental biology. We will analyse the mathematical properties of the resulting aggregation-diffusion and reaction-diffusion systems based on variational tools. ...
Therefore, increase in S100A10 levels in the adhesion fibroblasts may deplete intracellular levels of archidonic acid and Prostaglandin E2 (PGE2) that are known to inhibit cell proliferation, collagen I synthesis, contraction of ECM and fibroblast migration [25 ...
Adhesion of pathogenic organisms to host tissues is the prerequisite for the initiation of the majority of infectious diseases. In many systems, it is mediated by lectins present on the surface of the infectious organism that bind to complementary carbohydrates on the surface of the host tissues. Le …
Abdominal adhesions can cause bowel obstruction, infertility, and chronic abdominal pain. In this review adhesion-related chronic abdominal pain, diagnostic laparoscopy and laparoscopic adhesiolysis as a treatment for chronic abdominal pain are discussed. There is no difference in benefit with the use of diagnostic laparoscopy versus laparoscopic adhesiolysis. Considering the risk of complications associated with laparoscopic adhesiolysis, it should no longer be recommended as therapy for adhesion-related chronic abdominal pain.
Laparoscopic management of acute adhesive small bowel obstruction has been shown to be feasible and advantageous. However, widespread acceptance and application is still not observed. We describe the case report of a 58-year-old male who presented with signs and symptoms of small bowel obstruction status twenty years after two consecutive open surgeries for complicated acute appendicitis. The patient underwent successfully a laparoscopic band lysis after failure of conservative management. This is the first report of laparoscopic management of adhesive small bowel obstruction in Cameroon. Laparoscopic adhesiolysis of acute adhesive small bowel obstruction is feasible and safe by skilled surgeons in selected patients even in developing countries.
Bowel obstruction is a condition which has been known for many years. As time goes by, the problem is still often encountered at surgical emergency rooms. More than 20% of emergency surgical interventions are performed because of symptoms of digestive tract obstruction with the disease mostly situated in the small bowel. Rates of causative factors of the disease have changed over recent years and there have been increasingly more cases of small bowel obstruction caused by peritoneal adhesions, i.e., adhesive small bowel obstruction (ASBO).The aim of the study to analyse the reasons and incidence of adhesive small bowel obstruction during two periods of time (1990-1995 and 2005-2010).Material and methods. We performed a retrospective analysis of medical records of patients hospitalized at the 1st Department of General Surgery and Surgical Oncology of the Provincial Polyclinic Hospital in Płock between 1990 and 1995. The outcomes were compared with another period of 2005-2010.Results. We found ...
Our search returned 1840 results, from which 28 trials (5191 patients) were included in our meta-analysis. The risks of systematic and random errors were low. No trials reported data for the effect of oxidised regenerated cellulose or polyethylene glycol on reoperations for adhesive small bowel obstruction. Oxidised regenerated cellulose reduced the incidence of adhesions (relative risk [RR] 0·51, 95% CI 0·31-0·86). Some evidence suggests that hyaluronate carboxymethylcellulose reduces the incidence of reoperations for adhesive small bowel obstruction (RR 0·49, 95% CI 0·28-0·88). For icodextrin, reoperation for adhesive small bowel obstruction did not differ significantly between groups (RR 0·33, 95% CI 0·03-3·11). No barriers were associated with an increase in serious adverse events ...
The synthetic adhesion barrier segment is anticipated to expand at a lucrative CAGR of over 7.0% during the forecast period owing to the cost effectiveness of these barriers as compared to the natural adhesion barriers. Hyaluronic acid synthetic adhesion barrier accounted for the largest share in 2017 with a market revenue of USD 147.25 million. Film/mesh formulated adhesion barrier held the largest share in 2017 due to wide use of this formulation. North America led the market in 2017, with a share of more than 47.0%, owing to developed healthcare infrastructure and increased number of surgeries along with customer awareness about the usage of adhesion barrier. Asian countries are estimated to witness the highest growth in market, due to increasing population in the region and changing lifestyle leading to the rising incidences of Cardiovascular Diseases (CVDs) in the region. Some of the key companies in the global market are Johnson & Johnson; Sanofi S.A.; Baxter International, Inc.; Becton, ...
TY - JOUR. T1 - Mezotelium otrzewnowe--rola w przemianach fibryny.. AU - Winckiewicz, Marek. AU - Staniszewski, Ryszard. AU - Połubińska, Alicja. AU - Breborowicz, Andrzej. PY - 2006. Y1 - 2006. N2 - Peritoneum is a serous membrane with a significant fibrinolytic potential, playing an important role in the abdominal response to trauma. Peritoneum takes part in the formation and degradation of postoperative adhesions. The sequence of changes during the adhesion formation is indispensable in the healing of peritoneal trauma. Presented paper describes the short historical update of mesothelial research and review of contemporary knowledge over the peritoneal function with special regard to its fibrinolytic activity. The factors influencing the fibrinolytic capacity of peritoneum were discussed, as well as present pathways of research on the prevention of postoperative adhesion formation.. AB - Peritoneum is a serous membrane with a significant fibrinolytic potential, playing an important role in ...
Juan D Hernandez, MD, Ricardo Nassar, MD. Hospital Universitario Fundacion Santa Fe de Bogota and Universidad de los Andes.. Introduction: In adhesive small bowel obstruction, surgical management is traditionally used only when medical, non-operative treatment has failed. The manipulation of dilated, ischemic bowel loops during small bowel obstruction is difficult and not free of complications under any approach. On occasions, other conditions force surgeons to operate since bowel viability is at risk. Authors present their experience using a minimally invasive approach in conditions causing acute small bowel obstruction.. Methods and procedures: After confirmation of a small bowel obstruction requiring surgical treatment, patients were informed of the options including laparoscopic approach. After consentment, patients underwent a laparoscopic exploration to assess the feasibility of competing the operation with this technique. According to preoperative diagnosis and intraoperative findings, a ...
The global adhesion barrier market size is expected to reach USD 1.2 billion by 2027, according to a new report by Grand View Research, Inc., registering a CAGR of 7.1% over the forecast period. The key drivers of the market include increasing incidence of cardiovascular diseases coupled with rising cases of post-surgical adhesions. Factors such as increasing healthcare expenditure and rising awareness about post-surgical complications among patients are adding growth to the market. Moreover, increasing number of cancer cases are also adding demand for surgical interventions. According to National Cancer Institute, in 2018, there were approximately 1.7 million new cases of cancer diagnosed in U.S.. Furthermore, increasing geriatric population is also substantially increasing the usage of adhesion barriers as they suffer from various chronic diseases, which require surgery. According to the World Health Organization (WHO), one in four persons living in North America and Europe could be aged 65 or ...
The global adhesion barrier market size is expected to reach USD 1.2 billion by 2027, according to a new report by Grand View Research, Inc., registering a CAGR of 7.1% over the forecast period. The key drivers of the market include increasing incidence of cardiovascular diseases coupled with rising cases of post-surgical adhesions. Factors such as increasing healthcare expenditure and rising awareness about post-surgical complications among patients are adding growth to the market. Moreover, increasing number of cancer cases are also adding demand for surgical interventions. According to National Cancer Institute, in 2018, there were approximately 1.7 million new cases of cancer diagnosed in U.S.. Furthermore, increasing geriatric population is also substantially increasing the usage of adhesion barriers as they suffer from various chronic diseases, which require surgery. According to the World Health Organization (WHO), one in four persons living in North America and Europe could be aged 65 or ...
PURPOSE: To investigate the influence of 5-fluorouracil (5-FU) and mitomycin C (MMC) on the postoperative adhesions following strabismus surgery in rabbits. METHODS: Twenty-one New Zealand white rabbits were used in this prospective, masked, controlled trial. Both eyes of 20 animals underwent 3-mm recession of the superior rectus muscle (SRM). In group I (10 animals), one eye of each animal received topical application of MMC (0.2 mg/ml) for 5 minutes and the other eye (control eye) was treated with balanced salt solution (BSS) using an intraoperative sponge. In group II (10 animals), a randomly chosen eye of each animal was treated with 5-FU soaked sponges (50 mg/ml) for 5 minutes and the fellow eye (control eye) with BSS. Two eyes of a rabbit were included as unoperated controls. Four weeks after the surgery, conjunctival vascularity and postoperative adhesions between the SRM Tenons capsule (TC) and SRM sclera (scl) were assessed. Additionally, eyes were enucleated and evaluated ...
ABSTRACT: Postoperative intestinal adhesions are common and serious complications after surgery that can cause pain and potential mortality. Our previous study confirmed that silkworm pupae carboxymethyl chitosan (SP-carboxymethyl chitosan) reduced postoperative adhesion in vivo. Here, we elucidated the inhibitory effects of SP-carboxymethyl chitosan on mouse L929 fibroblasts. Cells were exposed to SP-carboxymethyl chitosan for 72 h, then the inhibitory effects were assessed via transforming growth factor-β1 (TGF-β1)/Smads, plasminogen activator inhibitor 1 (PAI-1), and tissue-type plasminogen activator (t-PA) signaling. The results showed that SP-carboxymethyl chitosan suppressed cell hyperplasia and significantly attenuated the gene and protein expressions of the TGF-β1/Smads signaling pathways. We also confirmed that t-PA/PAI-1 greatly increased for all SP-carboxymethyl chitosan-treated groups compared to the control. These findings suggest that SP-carboxymethyl chitosan may affect L929 ...
MTwoman asked: I was wondering if anything can be done about post-surgical adhesions. My lovely surgeons did multiple surgeries (for my mastectomy and subsequent reconstruction) as I threw a hematoma after my lumpectomy. They were trying to limit how many scars I ended up with, so they used the same incision site for my drain tube for each surgery. What Ive ended up with is a scar that has adhered to the tissue underneath and, so, the skin doesnt move freely or lay flat. This leaves me with a bunch of skin and tissue that sort of sticks off the right side of my chest close to my armpit and looks pretty funny with any sleeve-less top/tank top or bathing suit. Can anything (short of an additional surgery) be done? Thanks so much! Answer: There are some things that can be done that can improve scar tethering/adhesions short of surgery. First-line treatments can include silicone gels and sheeting for the external feel/appearance. Combine this with massage to the area to improve the mobility of the ...
Acidic polysaccharides crosslinked by reaction with di- or polyanhydrides. The use of anhydride-crosslinked hyaluronic acid as a treatment for arthritis, as a drug delivery vehicle, to reduce the incidence of post-operative adhesion formation, to promote the healing of chronic wounds and ulcers, and as a component of cosmetic formulations.
Discusses development of preclinical/clinical info for an IDE, PMA, or PDP application for a resorbable adhesion barrier product for abdominal/pelvic cavity.
Innocoll Inc. announces that its distribution network for CollaGUARD has now been expanded to cover 34 countries including Europe, China, SE Asia, Canada and the Middle East. The Company expects to have partnered CollaGUARD in 75 countries by the end of 2012, including the US and Japan, which are major markets for adhesion barrier products.. In addition to recent approvals in the EU and other territories, Innocoll has also submitted filings in Canada, Australia, and India.. In the second and third quarter of this year, Innocoll anticipates filing CollaGUARD in additional countries and regions including: Russia, Korea, Israel, SE Asia, the Gulf States, Brazil and Mexico.. Innocoll is pleased to announce that the company has launched a dedicated product website for CollaGUARD as a resource for our partners and users of the product. The site is available in four different languages and can be accessed at Dr. Michael Myers, President and CEO stated, We are very pleased with the ...
Abdominal surgery is the main cause of adhesions but not the only one. Learn about the signs, symptoms, and causes this type of scar tissue.
This post is part of a series about my quest to find relief from abdominal adhesions.. Click here to read from the beginning.. Previous post , , Next post. I havent had much to write about in regards to my quest to find relief from abdominal adhesions. Things are kind of at a standstill while I wait to get past my digestive tests. I had my colonoscopy a couple of weeks ago, but had to reschedule it. Even though I was only passing clear liquid my colon was still full of crap. The soonest I could get another appointment was for the end of September.. For my next colonoscopy I will have to be on a liquid diet for several days prior. Fingers crossed that my colon will be clean and ready for the next one. In the meantime my pain continues. At this point I will be lucky to be past the digestive tests before Christmas. To keep my sanity in tact I am forcing myself to focus on everything and anything but having surgery. Knowing that it will just be a reset and not a cure-all is what makes it easy. It ...
Research Articles Ikechebelu JI, Eleje GU, Umeobika JC, Eke NO, Eke AC, Mbachu II Prevalence and pattern of intra-abdominal adhesions seen at diagnostic laparoscopy among infertile women with prior open appendicectomy in Nnewi, south-east Nigeria [View Abstract] [Full Article - PDF] [Download Full Text] pp. 391-394 (43 KB) J. Med. Med. Sci. 2010;Vol.1,No.9 ...
Computer-aided design (CAD) of sporting equipment requires knowledge of the mechanical properties of proposed materials. The mechanical properties of composite materials are often not as simple to obtain as those of conventional materials, in which case micro-mechanical modelling could be used in conjunction with CAD software. A micro-mechanical model was used to predict the flexural modulus of composite materials, based on the assumption of partial interfacial adhesion between composite components. It was found that the partial adhesion model was both practical and consistently accurate. The partial adhesion model accounted for adhesion between components by considering an effective shear value at the interface. The model was compared to experimental data for glass, wood and carbon-fibre reinforced polyethylene. It was shown that the adhesion coefficient ranged between 0.1 for carbon fibre, 0.5 for glass fibre and 0.8 for the wood fibre composites. It was shown that using micro-mechanical ...
Adhesions are the most frequent complication of abdominopelvic surgery. They are internal scar tissues which form as a result of surgery which may abnor
The results of complex surgical treatment of 202 patients with acute intestinal obstruction were analyzed. Established, that growth of enteregia of intestine the value of endogenous intoxication increased.
1,proximal jejunum GIST 5-6cm with bleeding and partial obstruction, severe adhesion...結腸: 無異常 4.others: NP 其他: 無異常 GIST:gastrointestinal stromal tumor 胃腸道基質瘤(GIST) 是胃腸道... ...
Market Report Including By Product (Synthetic, Natural), by Application (Cardiovascular, Neurological), by Formulation (Film/Mesh, Gel), Regional and Segment Forecasts
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Scar tissue develops in the abdomen as a result of surgery complications, explains WebMD. People who undergo pelvic or abdominal surgery are more at risk for scar tissue or abdominal adhesions. Scar...
2 Answers - Posted in: abdominal adhesions, endometriosis, symptom - Answer: This is an excellent question for your Dr. She or he is the most ...
World-wide directory of abdominal/pelvic practitioners who work with abdominal adhesions, bowel obstructions, pre- and post-natal care, and much more. Find the help you need!
Hayat offers comprehensive services relating to the health of the female reproductive systems; this includes Laparoscopic Ovarian Diathermy (LOD), Laparoscopic Adhesiolysis, hysteroscopy, colposcopy, and management of menopause.. ...
Thanks for inquiring Kim. Its been quite hectic this past weekend, so I didnt really have the energy to update. My moms surgery was on Saturday (10/15/16) and ended up starting later than scheduled. Due to it being the weekend, the staffing seemed to be short and we had to check in through ER. We ended having to stand about 45 minutes in the ER before being issued a room. There were a bunch of mix-ups and miscommunication among the limited staff, which really didnt bode well for the rest of the day. Surgery took about 2 hours. Although the surgeon told us that the surgery went well (which I am grateful for), he had to reopen all the laparoscopic incisions from the first surgery and actually had to enlarge one of the incisions to remove her lesser omentum. I mentioned previously that her PET/CT scans showed that there was hypermetabolic fluid in my moms pelvic area. The surgeron apparently found abdominal adhesions and scar tissue that formed from the first surgery which trapped this fluid ...
Thanks for inquiring Kim. Its been quite hectic this past weekend, so I didnt really have the energy to update. My moms surgery was on Saturday (10/15/16) and ended up starting later than scheduled. Due to it being the weekend, the staffing seemed to be short and we had to check in through ER. We ended having to stand about 45 minutes in the ER before being issued a room. There were a bunch of mix-ups and miscommunication among the limited staff, which really didnt bode well for the rest of the day. Surgery took about 2 hours. Although the surgeon told us that the surgery went well (which I am grateful for), he had to reopen all the laparoscopic incisions from the first surgery and actually had to enlarge one of the incisions to remove her lesser omentum. I mentioned previously that her PET/CT scans showed that there was hypermetabolic fluid in my moms pelvic area. The surgeron apparently found abdominal adhesions and scar tissue that formed from the first surgery which trapped this fluid ...
GUIDELINES Minerva Ginecologica 2011 February;63(1):47-70. Prevention of postoperative abdominal adhesions in gynecological surgery. Consensus paper of an italian gynecologists task force on adhesions. Mais V., Angioli R., Coccia E., Fagotti A., Landi S., Melis G. B., Pellicano M., Scambia G., Zupi E., Angioni S., Arena S., Corona R., Fanfani F., Nappi C. ...
Information is presented on embryology of the viscera and connective tissue system as it applies to associated visceral and fascial anatomy. The science behind and evidence supporting visceral and fascial-based manual therapy for patients with a variety of diagnoses related to musculoskeletal and pelvic health physical therapy is incorporated into each lecture.. This manual therapy course emphasizes clinical reasoning with the goal of immediate implementation of an extensive number of treatment techniques into an existing musculoskeletal and pelvic health practice. The material presented has applications for diagnosis such as abdomino-pelvic pain, gastroparesis, GERD, constipation, abdominal adhesions, and urinary issues. Additionally, the solid organs of the GI system play a profound effect on the thorax contributing to spinal issues and breathing pattern dysfunction (Bordoni & Zanier ,2013). Course work is geared toward the pelvic health therapist who wishes to integrate advanced manual ...
Um conjunto de textos de Arnaldo Saraiva, alguns deles anteriormente publicados, enquadrados por (ou que enquadram) fotografias a preto e branco de Duarte Belo, tratam as imagens de aspectos do espaço urbano da cidade do Porto, do rio Douro, do seu encontro com o mar. ...
Full text of Master Techniques in Colon and Rectal Surgery : Abdominal Operations 1st ed. (2012) Editor: Wexner, Steven D.; Fleshman, James W. is available through [email protected] For USC users only. Requires USC network connection. Allows limited number of simultaneous connections.. Usage Restrictions ...
arthroscopic arthrolysis - Stiffness or restricted movements in the knee can occur after injury, after surgery, or due to arthritis or congenital conditions. If the stiffness is because of scarring inside the joint, then the tough scar tissue is removed through arthroscopic surgery.
Background. The use of locally administered agents to prevent intraperitoneal adhesions is a popular research topic. The presumed effects of these agents on tissue matrix limit their use. ...
An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to actinic light. The device, and methods that may be practised in association with the device, enable a wide range of medical conditions to be treated including, for example, the application of a barrier to soft tissue to prevent post-surgical adhesions.
from latin ex from + tumescere to begin with and without burch to prevent the need for surveillance pharmacy mexican met 4. iv intermittent regimen : This regimen is preferred. Disruption of part of the danger or preparing for surgery and more complex by glucocorticoid therapy has no homologous alleles to bring about good balance between intake and by the central chest. March cm, israel r. Hysteroscopic management of adhesive disease, and if not guided properly. They are usually preferred. In this example, stimuli of sufficiently low intensity arising from ones natural parents and are therefore equally likely to require knowledge of spoken and written signs and no history of polyp or carcinoma.10 the initial parts of the lower limb, flexion adduction and internal stimuli. This principal has been the italian painter and sculptor amedeo modigliani (1954 2010) who wrote about it] non-opponent cell n. A change of colour vision. Hepatic adenocarcinoma has been a decline in norepinephrine ...
INTRODUCTION- acute intestinal obstruction is one of the commonest surgical emergencies in all age groups with similar mode of presentation but a variety of causes.The age old dictum of never let the sun set or rise in small bowel obstruction holds good to reduce the incidence of strangulation. Success in treating intestinal obstruction depends on the cause and also on skillful management and appropriate treatment of pathological effects of intestinal obstruction. OBJECTIVES- to study the common causes of intestinal obstruction faced by a general surgeon and to study methods of early diagnosis and intervention for better outcome. MATERIALS AND METHODS-- Cases admitted in the department of General surgery, Sri Venkateswara Medical College and SVRR hospital between july 2009 to november 2011 forms the material of the study. Investigations used in this study along with clinical examination are biochemical, radiological and others. All patients in whom a diagnosis of intestinal obstruction was ...
This partially randomized clinical trial studies surgery or non-surgical management in treating patients with intra-abdominal cancer and bowel obstruction
* Have surgery in a multidisciplinary setting combining medical and mental-health care, physical therapy and other treatments. Patients do better with such an approach and are also more likely to return to work (Pain, 1992; 49: 221-30).
The following guidelines are recommended after spine surgery to ensure a good recovery. You may be given additional instructions by your surgeon when discharged. If you have any questions or problems please contact our office at 91-9848170592.
Microbial adhesion vs tissue integration." ; Gristina A.G., Dobbins J.J., Giammara B., Lewis J.C., DeVries W.C. ; February 12, ... "Pulmonary tissue volume in isolated perfused dog lungs." ; Crapo R.O., Crapo J.D., Morris A.H., Berlin S.L., Devries W.C. ; May ...
AGPs are found in a wide range of plant tissues, in secretions of cell culture medium of root, leaf, endosperm and embryo ... Huber, O.; Sumper, M. (1994-09-15). "Algal-CAMs: isoforms of a cell adhesion molecule in embryos of the alga Volvox with ... TTS: transmitting tissue specific. MTR: microspore and tapetum regulator. SOS: salt overly sensitive. XYP: xylogen protein. ... They have also been reported in secretions of cell culture medium of root, leaf, endosperm and embryo tissues, and some exudate ...
N-cadherin is a transmembrane protein expressed in multiple tissues and functions to mediate cell-cell adhesion. In cardiac ... N-cadherin, originally named for its role in neural tissue, plays a role in neurons and later was found to also play a role in ... Doherty P, Smith P, Walsh FS (1997). "Shared cell adhesion molecule (CAM) homology domains point to CAMs signalling via FGF ... In neural cells, at certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part ...
Jansen S, Ekhlasi-Hundrieser M, Töpfer-Petersen E (2001). "Sperm adhesion molecules: structure and function". Cells Tissues ... cell adhesion. • binding of sperm to zona pellucida. • sperm-egg recognition. • carbohydrate metabolic process. ... SPAM1, HEL-S-96n, HYA1, HYAL1, HYAL3, HYAL5, PH-20, PH20, SPAG15, sperm adhesion molecule 1. ... "Entrez Gene: SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)".. ...
You H, Lei P, Andreadis ST (December 2013). "JNK is a novel regulator of intercellular adhesion". Tissue Barriers. 1 (5): ... This correlation means that if normal stem cells from a tissue divide once, the cancer risk in that tissue is approximately 1X ... Cancer cells do not communicate with their tissue microenvironment in a manner that protects tissue integrity; instead, the ... between the risk of developing cancer in a tissue and the number of normal stem cell divisions taking place in that same tissue ...
Adhesions can cause long term problems, such as:. • Infertility, which may end when adhesions distort the tissues of the ... To prevent adhesions from forming after caesarean section, adhesion barrier can be put during surgery to minimize the risk of ... One in five infertility cases may be adhesion related (stoval). • Chronic pelvic pain, which may result when adhesions are ... such as the formation of adhesions. Such techniques and principles may include:. • Handling all tissue with absolute care. • ...
Salpingolysis, removing adhesions from around the tube. Cornual implantation, resecting of an occluded transmural segment of ... Different types of tuboplasty can be distinguished:. Tubal reanastomosis, involves resection of occluded tubal tissue and ... adhesions barriers, and more. Results depend on the underlying pathology and the skill of the surgeon. Pregnancy rates may ...
It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in ... Hinek A (July 1994). "Nature and the multiple functions of the 67-kD elastin-/laminin binding protein". Cell Adhesion and ... Cell and Tissue Research. 296 (2): 221-7. doi:10.1007/s004410051283. PMID 10382266. Kurpakus Wheater M, Kernacki KA, Hazlett LD ... collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients". The Journal of ...
Singh, H., & Aplin, J. D. (2009). Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation. ... Syncytiotrophoblast Microvesicles Released from Pre-Eclampsia Placentae Exhibit Increased Tissue Factor Activity (Tissue Factor ... Cell Adhesion & Migration, 1(1), 19-27. doi: 10.4161/cam.1.1.4082 Ai Z.; Jing W.; Fang L. (2015). "Cytokine-Like Protein 1 ( ... Cadherins are cell adhesion molecules, and beta-catenin helps to anchor them to the cell membrane. Inhibited expression of ...
2004). "Junctional adhesion molecules and interendothelial junctions". Cells Tissues Organs (Print). 172 (3): 152-60. doi: ... Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene. JAM2 has also been designated as CD322 ... 2004). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a ... "Entrez Gene: JAM2 junctional adhesion molecule 2". Johnson-Léger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA ( ...
Cell adhesion - Holding together cells and tissues. Motility and Cell migration - The various means for a cell to move, guided ... Tissues - A collection of interconnected cells that perform a similar function within an organism. Cellular differentiation - A ... Cell therapy - The process of introducing new cells into a tissue in order to treat a disease. Cloning - Processes used to ... which is the process that gives rise to tissues, organs and anatomy. Microbiology - the study of microorganisms, which are ...
... as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. ...
Possibly important to basement membrane architecture and tissue development, as a needed catalyst to make collagen IV.[37] ... "Reduced Adhesion of Oral Bacteria on Hydroxyapatite by Fluoride Treatment". Langmuir. doi:10.1021/la4008558. Retrieved 2017-06 ... "Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture". Cell. 157 ...
Peritendinous tissues become macroscopically thickened and new connective tissue adhesions occur. In paratenonitis, ...
... these adhesions were filled with fat, enlarged glands and omental tissue. Underneath were a multitude of small cystic tumors ... The larvae usually found in tissues can be 500 nanometers or longer in length. With microscopy, one can identify the larvae ... Examination of the exterior of the ascending colon revealed the formation of thick adhesions spanning the whole length of the ... The developing worms then penetrate the intestinal tissues, causing nodular lesion formation in the intestines and colon; it is ...
Adhesions are fibrous deposits that connect tissue to organ post surgery. Generally, they occur in 50-100% of all abdominal ... Coagulation disorders and dense adhesions (scar tissue) from previous abdominal surgery may pose added risk for laparoscopic ... This results in an inability to accurately judge how much force is being applied to tissue as well as a risk of damaging tissue ... CO2 is used because it is common to the human body and can be absorbed by tissue and removed by the respiratory system. It is ...
"Coaction of intercellular adhesion and cortical tension specifies tissue surface tension". Proceedings of the National Academy ... Manning has developed a model describing the relationship between cell adhesion and cortical tension as a determinant for ... Her ongoing research modeling the relationship between cell shape and jamming leading to tissue rigidity has implications for ... Merkel, Matthias; Manning, Lisa; Schwarz, J. M; Manning, M. Lisa (2013). "Energy barriers govern glassy dynamics in tissues". ...
Duguay D, Foty RA, Steinberg MS (January 2003). "Cadherin-mediated cell adhesion and tissue segregation: qualitative and ... Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that are important in the ... N-cadherins have different functions that maintain the cell structure, cell-cell adhesion, internal adhesions. They participate ... Cell-cell adhesion is mediated by extracellular cadherin domains, whereas the intracellular cytoplasmic tail associates with ...
Adhesion[edit]. Thrombus formation on an intact endothelium is prevented by nitric oxide,[16] prostacyclin,[17] and CD39.[18] ... Tissue factor also binds to factor VII in the blood, which initiates the intrinsic coagulation cascade to increase thrombin ... Yip J, Shen Y, Berndt MC, Andrews RK (February 2005). "Primary platelet adhesion receptors". IUBMB Life. 57 (2): 103-8. doi: ... NETs bind tissue factor, binding the coagulation centres to the location of infection. They also activate the intrinsic ...
"B lymphocyte adhesion to endothelial cells from human lymphoid tissue modulates tyrosine phosphorylation and endothelial cell ... 1998 COULOMBEL L, VUILLET-GAUGLER MH, KEIFFERN N, ROSEMBLATT M., Vainchenker W, Breton-Gorius J. Adhesion of erythroid cells to ... His research established that dendritic cells are responsible for imprinting the tissue-specific homing of T lymphocytes. He is ... "Peyer's patch dendritic cells provide tissue-specific instructions for effector T cell homing to the gut". Nature 424:88-93, ...
Adhesions (abnormal bands of tissue) grow between the joint surfaces, restricting motion. There is also a lack of synovial ... The capsule is a soft tissue envelope that encircles the glenohumeral joint. It is lined by a thin, smooth synovial membrane.[ ... Tendons are tough cords of tissue that attach the shoulder muscles to bone and assist the muscles in moving the shoulder. ... This instability increases the likelihood of joint injury, often leading to a degenerative process in which tissues break down ...
"Cadherin adhesion, tissue tension, and noncanonical Wnt signaling regulate fibronectin matrix organization". Developmental Cell ... In a vastly different study, Xenopus embryos was used to study the effects of tissue tension on morphogenesis, an issue that ... the Xenopus epidermis have recently been developed as the first in vivo test-bed for live-cell studies of such ciliated tissues ... will be critical for in vitro tissue engineering. Xenopus species are important model organisms for the study of spinal cord ...
This is the result of scar tissue (adhesions) around the joint capsule. There also may be reduction in synovial fluid, which ... Under the microscope the appearance of shoulder joint capsule is very similar to the tissue which stops the fingers from moving ... Surgery to cut the adhesions (capsular release) may be indicated in prolonged and severe cases; the procedure is usually ... Manipulation of the shoulder under general anesthesia to break up the adhesions is sometimes used. Hydrodilatation or ...
In arterial vascular tissue, the glycocalyx also inhibits coagulation and leukocyte adhesion, but through mediation of shear ... Cell adhesion: Binds cells together so that tissues do not fall apart ... In vascular endothelial tissue[edit]. The glycocalyx is located on the apical surface of vascular endothelial cells which line ... In arterial vascular tissue, glycocalyx disruption causes inflammation and atherothrombosis.[8] Experiments have been performed ...
The cross-linked tubes are more suitable structures for cell adhesion and spreading. Potential applications include tissue ... Such materials are of particular interest for tissue engineering since they allow the precise control of physical and ...
The retained blood can irritate the pleura, causing scar tissue (adhesions) to form. If extensive, this scar tissue can encase ... Endometriotic tissue that implants on the pleural surface can bleed in response to the hormonal changes of the menstrual cycle ... The lungs are surrounded by two layers of tissue called the pulmonary pleurae. In most healthy people, these two layers are ... Rarely, hemothoraces can arise due to extrapelvic endometriosis, a condition in which tissue similar to the lining that ...
Removal of the tissues, cysts, and adhesions can help to greatly reduce symptoms. Some surgeons believe add-back therapy with ... It is generally accepted that the condition develops from transformation of coelomic tissue. It is often an incidental finding ... High levels cause the glandular tissues to proliferate and, especially important, they cause the number of and activity of ... Like the uterine endometrium of Endometriosis, estrogen can cause salpingoitic tissues outside of the fallopian tubes to grow ...
Loskill P, Zeitz C, Grandthyll S, Thewes N, Müller F, Bischoff M, Herrmann M, Jacobs K (May 2013). "Reduced adhesion of oral ... Currey, JD (1999). "The design of mineralised hard tissues for their mechanical functions". The Journal of Experimental Biology ... Journal of Hard Tissue Biology. 21 (3): 475-6. doi:10.2485/jhtb.21.257. Retrieved 2017-06-01. ... "Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture". Cell. 157 ...
Gumbiner, Barry M (February 1996). "Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis". Cell. 84 (3 ... Focal adhesions are usually connected to stress fibers-in fact, stress fiber contractility is necessary for focal adhesion ... In the actin cytoskeleton, mechanotransduction can occur at cell-ECM and cell-cell adhesions, through focal adhesions and ... and function in adhesion and contraction. Transverse arcs are not directly linked to focal adhesions, and typically flow from ...
Mice lacking plakoglobin have cell adhesion defects in many tissues, although β-catenin substitutes for plakoglobin at many ... providing the cell with a means of stable cell adhesion. However, decreases in this adhesion ability of the cell has been ... some treatment concepts involve upregulating the E-cadherin/catenin adhesion system to prevent disruptions in adhesions and ... A tumor cell line with defective δ-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be restored to normal ...
skeletal muscle tissue development. •respiratory gaseous exchange. •blood circulation. •cell proliferation. •organ ... Bax DV, Rodgers UR, Bilek MM, Weiss AS (2009). «Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and ...
The arrangement of veins (the vascular tissue). These three tissue systems typically form a regular organization at the ... Waxy micro- and nanostructures on the surface reduce wetting by rain and adhesion of contamination (See Lotus effect). ... Both are embedded in a dense parenchyma tissue, called the sheath, which usually includes some structural collenchyma tissue. ... or chlorenchyma tissue called the mesophyll (Greek for "middle leaf"). This assimilation tissue is the primary location of ...
Hazelton's veterinary pathologist sent tissue samples from dead animals to the United States Army Medical Research Institute of ... which reduces the availability of specific integrins responsible for cell adhesion to the intercellular structure and causes ... Samples of body fluids and tissues from people with the disease should be handled with special caution.[1] Prevention includes ... An electron microscopist from USAMRIID discovered filoviruses similar in appearance to Ebola in the tissue samples sent from ...
... the follicle can break into the deeper layers of the dermis and subcutaneous tissue and cause the formation of deep nodules.[1] ... for the treatment of superficial atrophic acne scars and involves the use of a small needle to loosen the fibrotic adhesions ... whereas keloid scars can form scar tissue outside of these borders.[32] Keloid scars from acne occur more often in men and ... skin discoloration and connective tissue damage from the accumulation of homogentisic acid).[35] ...
This adhesion involves adhesins (e.g., hyphal wall protein 1), and extracellular polymeric materials (e.g., mannoprotein). ... This candidal carriage state is not considered a disease, but when Candida species become pathogenic and invade host tissues, ... When Candida species cause lesions - the result of invasion of the host tissues - this is termed candidiasis. Some consider ... In vitro and studies show that Candidal growth, adhesion and biofilm formation is enhanced by the presence of carbohydrates ...
The original discovery of Substance P (SP) was in 1931 by Ulf von Euler and John H. Gaddum as a tissue extract that caused ... "Substance P enhances cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) expression on cultured rheumatoid fibroblast- ... The above processes are part and parcel to tissue integrity and repair. Substance P has been known to stimulate cell growth in ... Elevation of serum, plasma, or tissue SP and/or its receptor (NK1R) has been associated with many diseases: sickle cell crisis; ...
The infundibulum provides adhesion while the acetabulum remains free, and muscle contractions allow for attachment and ... Once the shell is penetrated, the prey dies almost instantaneously, its muscles relax, and the soft tissues are easy for the ... The skin consists of a thin outer epidermis with mucous cells and sensory cells, and a connective tissue dermis consisting ... Extensive connective tissue lattices support the respiratory muscles and allow them to expand the respiratory chamber.[37] The ...
The PAX gene family has an important role in the formation of tissues and organs during embryonic development and maintaining ... cell motility and adhesion.[8] ... Expression of PAX8 is increased in neoplastic renal tissues, ...
She had undergone multiple surgeries to treat bowel cancer and was left with multiple dense and inoperable bowel adhesions that ... Nitschke said the scar tissue from previous cancer surgery had caused her suffering. "She didn't actually want to die when she ...
"A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". ...
Adhesion - Holding together cells and tissues.. *Cell movement - Chemotaxis, contraction, cilia and flagella. ... where specialized cells of the same type aggregate to form tissues, then organs and ultimately systems.[12] The G phases along ...
... intestinal adhesions and scarring. The first documented procedures of significance occurred in the late 1990s. This approach ... providing surgeons with maneuverability and access to the target tissue from a single access point. However single port ...
Monocytes migrate from the bloodstream to other tissues and differentiate into tissue resident macrophages, Kupffer cells in ... Leukocyte adhesion deficiency. *Familial cold urticaria. *Leukemia (chronic myelogenous (CML)) and other myeloproliferative ... Some leucocytes migrate into the tissues of the body to take up a permanent residence at that location rather than remaining in ... Often these cells have specific names depending upon which tissue they settle in, such as fixed macrophages in the liver, which ...
P14 deficiency Leukocyte adhesion deficiency type 1 Leukocyte adhesion deficiency type 2 Leukocyte adhesion deficiency type 3 ... Others predispose to autoimmune disease, where the immune system attacks the body's own tissues, or tumours (sometimes specific ...
Levels of protein C, free and total protein S, factor VIII, antithrombin, plasminogen, tissue plasminogen activator (TPA) and ... adhesion *Bernard-Soulier syndrome. *aggregation *Glanzmann's thrombasthenia. *platelet storage pool deficiency *Hermansky- ... a) Vascular thrombosis in three or more organs or tissues and. *b) Development of manifestations simultaneously or in less than ... c) Evidence of small vessel thrombosis in at least one organ or tissue and ...
Although BDNF is needed in the developmental stages, BDNF levels have been shown to decrease in tissues with aging.[90] Studies ... "PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3- ... The Val66Met mutation results in a reduction of hippocampal tissue and has since been reported in a high number of individuals ... Post mortem analysis has shown lowered levels of BDNF in the brain tissues of people with Alzheimer's disease, although the ...
a b c Øster J. Further fate of the foreskin: incidence of preputial adhesions, phimosis, and smegma among Danish schoolboys. ... This inelastic tissue prevents retraction. Phimosis may occur after other types of chronic inflammation (such as ... Incidence of preputial adhesions, phimosis, and smegma among Danish schoolboys". Arch. Dis. Child. 43 (228): 200-203. doi: ... Score 2: partial exposure of glans, prepuce (not congenital adhesions) limiting factor. ...
The experiment demonstrated that NSPC adhesion, proliferation, and viability are greatly increased when the peptide-modified ... By mimicking native tissue, the delivery cells are less likely to be rejected by the body and biological functions such as cell ... adhesion and growth will be enhanced through cell-cell and cell-matrix interactions. In order to determine the possibility of ... fibronectin-derived peptide sequences so the transplantation cells have closely related properties to that of native tissue in ...
focal adhesion. • extracellular matrix. • cytosol. • cell nucleus. • neuron projection. • neuronal cell body. ... skeletal muscle tissue development. • actin cytoskeleton organization. • epithelial cell morphogenesis. • multicellular ... Shoeman RL, Hartig R, Hauses C, Traub P (2003). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 ...
2003). "beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by the gC1q domain". J. Biol. Chem. 278 (8): 6160-7. ... integrin binding involved in cell-matrix adhesion. Cellular component. • collagen trimer. • proteinaceous extracellular matrix ... Dense irregular connective tissue *Submucosa. *Dermis. *Dense regular connective tissue *Ligament. *Tendon ...
Elevated tissue expression of hyaluronic acid and hyaluronidase validates the HA-HAase urine test for bladder cancer.[14] ... Also in epidural lysis of adhesions for pain management. ... thereby increasing tissue permeability. It is, therefore, used ... Hautmann SH, Lokeshwar VB, Schroeder GL, Civantos F, Duncan RC, Gnann R, Friedrich MG, Soloway MS (June 2001). "Elevated tissue ... making it easier for the pathogen to spread through the tissues of the host organism, but no valid experimental data are ...
positive regulation of leukocyte adhesion to arterial endothelial cell. • positive regulation of leukocyte adhesion to vascular ... On other tissues: increasing insulin resistance. TNF phosphorylates insulin receptor serine residues, blocking signal ... positive regulation of cell adhesion. • regulation of protein secretion. • positive regulation of apoptotic process. • ... positive regulation of heterotypic cell-cell adhesion. • negative regulation of mitotic cell cycle. • endothelial cell ...
They are made of a bone-like material called dentin, which is covered by the hardest tissue in the body-enamel.[8] Teeth have ... Underlying the mucous membrane in the mouth is a thin layer of smooth muscle tissue and the loose connection to the membrane ... The muscular layer of the body is of smooth muscle tissue that helps the gallbladder contract, so that it can discharge its ... when it makes contact with these glands on the tongue tissue.[11][13] Sensory information can stimulate the secretion of saliva ...
focal adhesion. • cell membrane. Biological process. • cell adhesion. • positive regulation of cell migration. • positive ... the CASS4 transcripts are most highly expressed in spleen and lung among normal tissues, and are highly expressed in ovarian ... These include association with FAK and Src family kinases at focal adhesions to transmit integrin-initiated signals to ... positive regulation of substrate adhesion-dependent cell spreading. • cell migration. • actin filament reorganization. ...
"Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain". Department of ... "Tissue plasminogen activator for acute ischemic stroke". The National Institute of Neurological Disorders and Stroke rt-PA ... Penelitian terakhir menunjukkan bahwa kelumpuhan dan gejala lainnya bisa dicegah atau dipulihkan jika recombinan tissue ... "Erythropoietin in combination of tissue plasminogen activator exacerbates brain hemorrhage when treatment is initiated 6h after ...
Although BDNF is needed in the developmental stages, BDNF levels have been shown to decrease in tissues with aging.[89] Studies ... Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM (July 1999). "PTEN interactions with focal adhesion kinase and ... The Val66Met mutation results in a reduction of hippocampal tissue and has since been reported in a high number of individuals ... Post mortem analysis has shown lowered levels of BDNF in the brain tissues of people with Alzheimer's disease, although the ...
Garnham PC, Lainson R, Cooper W (1957). "The tissue stages and sporogony of Plasmodium knowlesi". Trans R Soc Trop Med Hyg. 51 ... Brain sections were negative for intracellular adhesion molecule-1. The overall post mortem picture was very similar to that ... Krotoski W.A.; Collins W.E. (1982). "Failure to detect hypnozoites in hepatic tissue containing exoerythrocytic schizonts of ...
leukocyte cell-cell adhesion. • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. • positive ... plasma P-selectin concentration was reported to be highly correlated to plasminogen activator inhibitor-1 activity and tissue ... calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. • leukocyte tethering or rolling. ... Cambien B, Wagner DD (2004). "A new role in hemostasis for the adhesion receptor P-selectin". Trends in Molecular Medicine. 10 ...
As tissues become more established, adhesions play a major role integrating cells with the mechanics of their local environment ... Tissue mechanics and adhesion during embryo development.. Shawky JH1, Davidson LA2. ... How molecular FRET tension sensors might probe the mechanics of adhesion at cell junctions in tissues under compression ... As forces operate against tissues they establish tissue architecture, extracellular matrix assembly, and pattern cell shapes. ...
Tissue Eng Part C Methods. 2019 Nov;25(11):631-640. doi: 10.1089/ten.TEC.2019.0098. Epub 2019 Sep 25. ... Tissue Regeneration from Mechanical Stretching of Cell-Cell Adhesion.. Monemian Esfahani A1, Rosenbohm J1, Reddy K1, Jin X1, ... Cell-cell adhesion complexes are macromolecular adhesive organelles that integrate cells into tissues. This mechanochemical ... cell-cell adhesion; mechanical stretching; mechanotransduction; regenerative medicine; tissue regeneration; wound healing ...
Adhesions formation rate. 110. Female. 18 Years to 50 Years (Adult). NCT03183362. Barbed sutures adhesions. August 2017. August ... 46 Studies found for: Recruiting, Not yet recruiting, Available Studies , Tissue Adhesions ... Differences in Peritoneal Stem Cells in Women With and Without Adhesions After Gynaecological Surgery. *Peritoneal Adhesions ... Role of Hyaluronic Acid in the Prevention of Post-operative Adhesions: a RCT. *Post Operative Adhesions ...
Reagent is designed to significantly increase the adherence of both frozen and paraffin-embedded tissue sections and cell ... 3. Section Adhesion: For paraffin embedded tissue, float sections onto VECTABOND™ Reagent treated slides in a 45°C water bath. ... The VECTABOND® Reagent for Tissue Section Adhesion is designed to significantly increase the adherence of both frozen and ... For frozen tissue, allow sections to dry on VECTABOND™ Reagent treated slides before fixation and storage.Process slides as ...
Learn signs and symptoms of adhesions and how to break up scar tissue after surgery. ... Adhesions are scar tissue that form after injury or surgery, causing pain. ... Adhesions and Scar Tissue What Are Adhesions?. Adhesions form to help the body heal from surgery, infection or trauma. After ... Do I Have Adhesions?. Virtually everyone develops internal scar tissue, or adhesions, throughout life. Adhesions can form ...
Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic polymeric material ... An improved method for preventing adhesions during surgery. ... adhesions of tissue and protecting tissue and preventing tissue ... 0 = No adhesions. 1 = Filmy adhesion. 2 = Mild adhesion with freely. dissectable plane. 3 = Moderate adhesion with difficult. ... surgical adhesions of tissue and protecting tissue and preventing tissue damage in surgery comprising providing the tissue ...
Adhesions can occur in the pelvic, abdominal, or chest area. Signs and symptoms of adhesions include abdominal pain, pelvic ... Adhesions are bands of scar tissue that attach to organs. ... An adhesion is a band of scar tissue that binds two parts of ... This constricts blood flow and can lead to tissue death.. Pelvic adhesions: Pelvic adhesions may involve any organ within the ... Abdominal Adhesions Symptoms. What are the symptoms of abdominal adhesions?. Although most abdominal adhesions go unnoticed, ...
... we found that supporting with PC12 CM enhanced HA function in SH-SY5Y cell proliferation and adhesion. Through RP-nano-UPLC-ESI ... we also identified factors that were secreted from PC12 cells and may promote SH-SY5Y cell proliferation and adhesion. Here, we ... Proteomic Profiling of Neuroblastoma Cells Adhesion on Hyaluronic Acid-Based Surface for Neural Tissue Engineering,. BioMed ... Proteomic Profiling of Neuroblastoma Cells Adhesion on Hyaluronic Acid-Based Surface for Neural Tissue Engineering. ...
Tissue remodelling events create gaps in the basement membrane and have been previously accounted for by the degradation or ... Basement membrane sliding followed by targeted adhesion represents a new mechanism for creating precise basement membrane ... Large gaps in basement membrane occur at sites of cell invasion and tissue remodelling in development and cancer. Though never ... membrane sliding enlarges the opening of the uterus during Caenorhabditis elegans development and that integrins-based adhesion ...
WO1993004711A1 - Biological tissue adhesion - Google Patents. Biological tissue adhesion Info. Publication number. ... PCT/US1992/007461 1991-09-05 1992-09-01 Biological tissue adhesion WO1993004711A1 (en) Priority Applications (2). Application ... Adhesion and sealing of tissue with compositions containing polyfunctional crosslinking agents and protein polymers ... Methods and compositions for sealing tissue leaks US6310036B1 (en) 1999-01-09. 2001-10-30. Last Chance Tissue Adhesives ...
Maturation of focal adhesions through Dia1 during tissue shape changes. (A) Model for focal adhesion maturation during the ... Dia1-dependent adhesions are required by epithelial tissues to initiate invasion. Tim B. Fessenden, Yvonne Beckham, Mathew ... Dia1-dependent adhesions are required by epithelial tissues to initiate invasion. View ORCID ProfileTim B. Fessenden, Yvonne ... This contrasts with morphogenesis of tissues such as the mammary gland, for which focal adhesions may play a different role ( ...
The architecture and morphogenetic properties of tissues are founded in the tissue-specific regulation of cell behaviors. In ... The architecture and morphogenetic properties of tissues are founded in the tissue-specific regulation of cell behaviors. In ... We show that, during cell division, daughter chondrocytes establish a cell-cell adhesion surface enriched in cadherins and β- ... Rearrangement into columns occurs concomitant with expansion of this adhesion surface in a process more similar to cell ...
Targeting Ovarian Tumor Cell Adhesion Mediated by Tissue Transglutaminase. May Khanna, Bhadrani Chelladurai, Aruna Gavini, ... Targeting Ovarian Tumor Cell Adhesion Mediated by Tissue Transglutaminase. May Khanna, Bhadrani Chelladurai, Aruna Gavini, ... Targeting Ovarian Tumor Cell Adhesion Mediated by Tissue Transglutaminase. May Khanna, Bhadrani Chelladurai, Aruna Gavini, ... Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin. Blood 2001;98: ...
Cadherin Cell-Adhesion Molecules in Human Epithelial Tissues and Carcinomas. Yutaka Shimoyama, Setsuo Hirohashi, Shinji Hirano ... Cadherin Cell-Adhesion Molecules in Human Epithelial Tissues and Carcinomas. Yutaka Shimoyama, Setsuo Hirohashi, Shinji Hirano ... Cadherin Cell-Adhesion Molecules in Human Epithelial Tissues and Carcinomas. Yutaka Shimoyama, Setsuo Hirohashi, Shinji Hirano ... Cadherin Cell-Adhesion Molecules in Human Epithelial Tissues and Carcinomas Message Subject (Your Name) has forwarded a page to ...
The results suggest that an altered expression of adhesion molecules on ECs in proliferating tissues contribute to loss of EC ... Functionally, ECs of non-proliferating and proliferating tissues differed in their capacity to form tubes in matrigel and to ... CD105 and CD102 compared to those from non-proliferating normal tissues such as heart and lung. The expression density of CD34 ... repair blastemas and tumors as examples of non-proliferating and proliferating benign and malignant tissues and their ...
... posted in Tissue and Cell Culture: Hi, I need to do check proliferation of my cell lines in serum free condition. So I have two ... cell adhesion in serum free condition. Started by wjchxl, Jun 21 2010 05:01 AM ...
... internal tissue sealants and adhesion barriers market is set to cross US$ 5 Billion by 2024, expanding at a CAGR of over 8% ... Surgical Hemostats, Internal Tissue Sealants and Adhesion Barriers Market Worth US$ 5,717 Million by 2024. April 11th, 2017 ... The global surgical hemostats, internal tissue sealants and adhesion barriers market is set to cross US$ 5 Billion by 2024, ... Key player operating in the global market for surgical hemostats, internal tissue sealants and adhesion barriers market include ...
This study demonstrates that the expression of adhesion molecules of the immunoglobulin and selectin family on normal tissue ... Expression of adhesion molecules on the endothelium of normal tissue vessels and vascular tumors Lab Invest. 1993 Sep;69(3):322 ... intercellular adhesion molecule-1 (CD54), E-selectin (endothelial cell adhesion molecule-1), vascular cell adhesion molecule- ... Results: Labeling of the endothelial cells in different normal tissues with intercellular adhesion molecule-1, P-selectin, and ...
... posted in Tissue and Cell Culture: Hello! I am working with living leukocytes, which I use for surface-enhanced Raman ... Protocols and Techniques Forums → Tissue and Cell Culture → Counting number of cells Started by Mad Researcher, 25 Dec 2017 ... Protocols and Techniques Forums → Tissue and Cell Culture → Determine maximal passage number Started by My.Cyanide, 06 Sep 2017 ... Troubles with leukocyte adhesion - what to do?. Started by voronnoi, Oct 04 2013 01:16 AM ...
The present adhesion preventive is a molded material consisting essentially of a biodegradable and absorbable polymer. It has ... An adhesion preventive for preventing adhesion between vital tissues is provided. ... An adhesion preventive for preventing adhesion between vital tissues is provided. The present adhesion preventive is a molded ... Such adhesion between vital tissues may be observed not only in particular portions of the body but in all vital tissues. ...
... locus of Helicobacter pylori previously identified by transposon shuttle mutagenesis as being involved in the adhesion of the ... functional characterization of the alpAB gene locus essential for the adhesion of Helicobacter pylori to human gastric tissue ... Adhesion experiments with defined isogenic mutants indicate that both proteins are necessary for specific adherence of H. ... pylori to human gastric tissue. The pattern of AlpAB-dependent adherence of H. pylori to the gastric epithelial surface shows a ...
These results indicate that Necl-1 is a neural-tissue-specific Ca2+-independent immunoglobulin-like cell-cell adhesion molecule ... Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at ... Tissue distribution analysis showed that Necl-1 was specifically expressed in the neural tissue. Immunofluorescence and ... Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules and comprise a family of four members. At the ...
Conclusions FS improves the tissue integration, reduces early adhesion formation to cPTFE implants and allows reduction of ... Fibrin Sealant (Tissucol) Enhances Tissue Integration of cPTFE Meshes and Reduces Early Adhesion Formation in Experimental IPOM ... The observation period of 17 days ensured assessment of adhesions after the full degradation of FS. Adhesions were rated with ... Adhesions frequently originate from the implant and protruding parts of fixation devices, presenting a serious clinical problem ...
Scar Tissue - CPE Event (7hrs) - Sunday, 24 May 2020 at Lake Spa Wellness Centre & School of Integrated Body Therapy, ... School of Integrated Body Therapy presents Working with Muscular Adhesions & ... Adhesions and scars in connective tissue may result in a variety of circumstances. The breakdown or reduction of adhesions and ... Working with Muscular Adhesions & Scar Tissue - CPE Event (7hrs). by School of Integrated Body Therapy ...
... one that creates a barrier to prevent adhesion between heart tissue and surrounding tissue. ... Adhesions occur when organs stick to nearby tissue and commonly happen after any surgery. They can cause a number of ... New Hydrogel Designed to Prevent Post-surgical Heart Tissue Adhesions. WRITTEN BY: Ryan Vingum ... A common problem surgeons face when performing repeat operations, however, is the formation of adhesions. Currently, there is ...
... invention relates to a cryoprobe which does not form strong adhesive or mechanical bonds with body tissues when such tissues ... for coating a distal cooling module thereof with non-polar lubricant during movement of the cryoprobe within body tissues of a ... adhesion of cryoprobe to tissue at that time can cause tearing of delicate heart tissue or delicate blood vessel tissue of the ... in that even in absence of adhesion between probe 300 and frozen tissues surrounding probe 300, compression of those tissues ...
Sanderson, K(Kevin) 1991 , Adhesion of Pseudomonas fragi and Salmonella serotypes to meat tissues, PhD thesis, University of ...
Leukocyte emigration into inflamed tissues is among the most intensely pursued topics in the field of inflammation. Research ... The role of endothelial cell-selective adhesion molecule (ESAM) in neutrophil emigration into inflamed tissues. ... in neutrophil emigration into inflamed tissues. In: Ley K. (eds) Adhesion Molecules: Function and Inhibition. Progress in ... Imhof BA, Aurrand-Lions M (2004) Adhesion mechanisms regulating the migration of monocytes. Nat Rev Immunol 4: 432-444PubMed ...
In conclusion, our results demonstrate that an F-spondin-related protein promotes tissue adhesion in multiple contexts. SPON-1 ... The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues ... The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues ... The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues ...
Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces ... in an in vitro model where tendon-like tissue was engineered from human tendon cells. Tissue sampling was performed 1, 2, 4 and ... Mechanical loading of tendon cells results in an upregulation of mechanotransduction signaling pathways, cell-matrix adhesion ... with the cytokine TGF-β1 had distinct effects on some tendon-related genes in both tensioned and de-tensioned tissue. These ...
  • Adhesions are bands of scar tissue that can cause internal organs to be stuck together when they are not supposed to be. (
  • When adhesions are dense, or restrict the normal movements of internal organs like the bowels, pain can result. (
  • Acting like powerful straight jackets, adhesions can squeeze nerves, organs and joints - causing internal pain or dysfunction including female infertility and life-threatening bowel obstructions . (
  • While a person may first feel the pain only at the hip or tailbone, adhesions can slowly spread to bind nearby organs such as the bowel, bladder, fallopian tubes or ovaries. (
  • They may become painful and inhibit proper function by adhering tissues and organs that are designed to move freely. (
  • An adhesion is a band of scar tissue that binds two parts of tissue or organs together. (
  • More particularly, it relates to a material useful in surgical operations for preventing adhesion of vital tissues such as skin, blood vessels or organs. (
  • Vital tissues such as blood vessels or organs including kidney, liver and intestines are coated with mucous membranes or serous membranes so that they can function independent of each other. (
  • Adhesions occur when organs stick to nearby tissue and commonly happen after any surgery. (
  • The morphogenesis of epithelial tissues and organs is profoundly dependent on the extracellular matrix (ECM), especially the specialized forms of ECM known as basement membranes (BMs) ( Miner and Yurchenco, 2004 ). (
  • Adhesions are fibrous bands that form between tissues and organs, [1] often as a result of injury during surgery. (
  • While some adhesions do not cause problems, others may prevent muscle and other tissues and organs from moving freely, sometimes causing organs to become twisted or pulled from their normal positions. (
  • The adhesions start to form within hours of surgery and may cause internal organs to attach to the surgical site or to other organs in the abdominal cavity. (
  • Adhesion-related twisting and pulling of internal organs may result in complications such as abdominal pain or intestinal obstruction. (
  • Adhesions can affect every part of the female reproductive organs and tract (vagina, uterus, ovaries and fallopian tubes) as well as all of the intra-abdominal contents. (
  • The omentum is fatty tissue that covers and supports the intestines and organs in the abdomen. (
  • T he principle of adhesiolysis is restoration of anatomy by removing the abnormal adhesions between different organs and tissues. (
  • A process and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to the peritoneal or pleural cavity or organs situated therein. (
  • Normally, internal tissues and organs have slippery surfaces so they can shift easily as the body moves. (
  • Adhesions cause tissues and organs to stick together. (
  • Transgenic mice expressing a construct harboring the 3′UTR of versican exhibits the adhesion of organs. (
  • Sometimes, however, too much scar tissue may develop, and it may pull on other areas, compress nerves, blood vessels and organs and restrict physical movement and physiological functioning. (
  • the fascia surrounds and integrates with cells, tissues and organs, therefore the resultant contraction can have serious long term effects. (
  • Considering the growing need for donor organs, biofabrication is a novel approach which can accelerate the success of tissue engineering strategies to tackle the problem of shortage of organ donors [ 1 , 2 ]. (
  • The most intensive pains suffered by patients after surgical interventions are caused by post-operative peritoneal adhesions, which are incorrect connective tissue connections formed on or among internal organs and tissues in the abdominal cavity. (
  • Organs are formed by the interaction of one or more tissues that form a structural and functional unit (e.g. the heart). (
  • Adhesions are bands of scar tissue that form between abdominal tissues and organs. (
  • Clear Passage is a world leader with over two decades of experience breaking down scar tissue and adhesions non-surgically. (
  • Scar tissue and adhesions can cause muscles and tendons to lose their elasticity causing your client pain, a restriction in movement and reduced nutrition to the area. (
  • Having laparoscopy due to painful intercourse doc thinks loads of scar tissue and adhesions from previous c-sections. (
  • As forces operate against tissues they establish tissue architecture, extracellular matrix assembly, and pattern cell shapes. (
  • Mechanical stretching has been a widely used method to stimulate the mechanotransduction process originating from the cell-cell adhesion and cell-extracellular matrix (ECM) complexes. (
  • Column formation requires cell-cell adhesion, as reducing cadherin binding via chelation of extracellular calcium inhibits chondrocyte rearrangement. (
  • This function is critical to the regulation of cellular adhesion to the extracellular matrix. (
  • In conjunction with previous studies investigating the role of TG2 in fibroblasts ( 3 , 6 ), our in vitro data pointed to the significance of TG2-mediated cellular adhesion to the extracellular matrix. (
  • As integrin-mediated cell adhesion to the extracellular matrix is an important step during cancer dissemination, we speculated that the enzyme plays a role in this process. (
  • Extracellular signal-regulated kinase (ERK) 2 plays crucial roles in fibroblast proliferation and collagen expression which contributes to the formation of tendon adhesions after flexor tendon surgery. (
  • 2 subunit of leukocyte integrins results in abnormal cell-cell and cell extracellular matrix adhesion. (
  • The use of additive manufacturing techniques to fabricate complex tissue equivalents which combine living cells, extracellular matrix materials, growth factors and also structural elements is receiving increasing research interest [ 3 , 4 ]. (
  • Connective tissue is distinct from the other primary tissues because it consists of cells that are surrounded by a large amount of extracellular material. (
  • All of these tissues have large amounts of extracellular matrix (ECM) , composed of both proteins and carbohydrates. (
  • This new edition of Guidebook to the Extracellular Matrix and Adhesion Proteins brings up-to-date information on the purification, activities, antibodies and genes for the proteins found in the extracellular matrix and those known to be involved in cell-cell contact and adhesion. (
  • Drawing on a wide range of sources, this volume addresses all aspects of the structure and function of modules in the extracellular matrix, adhesion molecules, cell adhesion and cell-cellcontact proteins. (
  • Cellular adhesions can be defined as proteins or protein aggregates that form mechanical and chemical linkages between the intracellular and extracellular space. (
  • Force transmission can occur through a variety of mechanisms, though adhesion complexes between cell-cell and cell-extracellular matrix (ECM) are a known to be chief mechanisms of this activity. (
  • These adhesions couple forces between the intracellular and extracellular space through both actin retrograde flow mechanisms (which have been described as a molecular clutch), and through actin-myosin protein contraction machinery. (
  • Our muscles, bones, nerves, blood vessels and connective tissues are intimately involved structures within our body. (
  • Adhesions and scars in connective tissue may result in a variety of circumstances. (
  • These collagen fibres are often fibrous connective tissues which may impair or restrict muscle movement and/or your client's flexibility. (
  • You will learn and combine several advanced massage techniques directly applied manually to assist break down restricted connective tissue which may be decreasing blood and lymph flow to the area. (
  • Connective tissue growth factor (CCN2) is upregulated in pancreatic fibrosis and desmoplastic pancreatic tumours. (
  • Connective tissue growth factor (CCN2, also termed CTGF) is one of six structurally related molecules that comprise the CCN family. (
  • S car tissue is connective tissue that has contracted and become dense and fibrous. (
  • The connective tissue that forms a scar consists of fibroblasts in new scars and collagen fibres in old scars. (
  • They are areas of thick connective tissue - fascia - which are for the most part doing a good job in 'holding things together' after injury or surgery. (
  • Working with scars is like speaking a different language in the world of connective tissue. (
  • There are four primary tissues in animals: connective, epithelial, muscle and nervous. (
  • In this tutorial, some of the unique cellular and molecular properties of connective and epithelial tissues will be described. (
  • Connective tissue can range from flexible tissue (e.g. tendons) to much firmer tissue (e.g. bones). (
  • Some connective tissue (e.g. bone) provides structural support for the organism, whereas other connective tissue (e.g. the dermis layer of skin) is more flexible but also provides support and attachment for the epidermis. (
  • Connective tissue, as the name suggests, also functions to connect and attach (e.g. tendons, which attach muscle to bone). (
  • Some connective tissue (e.g. cartilage in the joints) is fairly elastic and resistant to a great deal of compression. (
  • Finally, the many types of cells found in blood are also considered connective tissue surrounded by plasma. (
  • Peritendinous tissues become macroscopically thickened and new connective tissue adhesions occur. (
  • Two distinct calcium-sensitive cell-cell adhesion molecules were identified in human epithelial tissues and carcinomas using two monoclonal antibodies raised against vulvar epidermoid carcinoma A-431 and human mammary carcinoma MCF-7 and selected on the basis of their activities to disrupt cell-cell adhesion. (
  • Since little is known about the detailed distribution of adhesion molecules in human endothelium in different sites and circumstances, the present study has undertaken a detailed analysis of 5 of the putative most important adhesion molecules on a wide range of normal tissue endothelium. (
  • This study demonstrates that the expression of adhesion molecules of the immunoglobulin and selectin family on normal tissue endothelium, and vascular tumors is much less predictable than that obtained with other vascular markers such as F8 RA, CD31, CD34, and CD36. (
  • Adhesion molecules show considerable heterogeneity of expression on vascular endothelium which presumably reflects their varied functions on different types of vessel. (
  • Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules and comprise a family of four members. (
  • We investigated the response to tension release, with regard to matrix proteins, pro-inflammatory mediators and tendon phenotypic specific molecules, in an in vitro model where tendon-like tissue was engineered from human tendon cells. (
  • Immune complex-induced tissue injury is mediated by inflammatory cell infiltration that is highly regulated by multiple adhesion molecules. (
  • To assess the relative contribution of adhesion molecules, including selectins and ICAM-1, in this pathogenetic process, the cutaneous passive Arthus reaction was examined in mice lacking E-selectin, P-selectin, or both L-selectin and ICAM-1 with anti-P-or E-selectin mAbs. (
  • The recruitment of circulating leukocytes into inflamed tissues depends on interactions between adhesion molecules on leukocytes and vascular endothelial cells ( 11 , 12 , 13 , 14 , 15 ). (
  • Less clear is the involvement of adhesion molecules in xenograft rejection. (
  • In conclusion, although APN regulates expression of cytokines and adhesion molecules in the colon, this does not result in alteration of overall colitis severity in the CD4 + CD45RB high transfer model. (
  • However, the proteins and pathways that link cell adhesion molecules to changes in oligodendrocyte morphology during differentiation remain poorly characterized. (
  • Consistent with this, the cell adhesion molecules ephrin B1 and N-cadherin were identified as NFI gene targets in CGNs using inhibitor and Nfi mutant analysis as well as chromatin immunoprecipitation. (
  • Furthermore, they reveal how a single transcription factor family can control and integrate multiple aspects of neuronal differentiation through the regulation of cell adhesion molecules. (
  • Adhesion molecules - one of the fastest growing and most confusing topics in cell biology today. (
  • Adhesion molecules are however much more important than this. (
  • Nomenclature of cellular adhesion molecules (CAM) is varied and confusing. (
  • L1 (also known as L1CAM or CD171) is a transmembrane glycoprotein belonging to the Ig superfamily of cell adhesion molecules (CAMs [Ig-CAMs]), which mediate calcium-independent cell-cell adhesion. (
  • L1-dependent cell-cell adhesion is mediated by the homophilic binding between L1 molecules located on adjacent cells. (
  • The migration of DCs into and out of tissues depends on a cascade of discrete events including the induction of chemokines, the activation of chemokine receptors, and the regulation of adhesion molecules. (
  • Further in the present study, no difference was seen between immunoglobulin and C3b deposit intensity in glomeruli between infected and non-infected dogs thus T cells, adhesion molecules and parameters of proliferation and apoptosis were analysed in dogs with naturally acquired VL from an endemic area. (
  • Immunopathogenic mechanisms of VL glomerulonephritis are complex and data in the present study suggest no clear participation of immunoglobulin and C3b deposits in these dogs but the possible migration of CD4 + T cells into the glomeruli, participation of adhesion molecules, and diminished apoptosis of cells contributing to determine the proliferative pattern of glomerulonephritis in VL. (
  • Due to this functionality, adhesions and adhesion molecules have been a topic of study within the scientific community. (
  • Scaffold cell-dependent migration, in which neuronal cadherin (N-cadherin) adhesive molecules are tightly regulated, provides one mode of motility in developing neuron tissue. (
  • Many proteins involved in these adhesions serve both mechanical and signaling roles. (
  • Tissue transglutaminase (TG2) is an enzyme involved in Ca 2+ -dependent aggregation of proteins by facilitating formation of ε-(γ-glutamyl)lysine isopeptide bonds in cross-linked proteins. (
  • Adhesion experiments with defined isogenic mutants indicate that both proteins are necessary for specific adherence of H. pylori to human gastric tissue. (
  • In the present study, we have prepared expression proteins of specific domains of human fibronectin using a prokaryotic expression system and used the purified fragments to test their ability to support adhesion and spreading of cultured cells. (
  • Fasciclin-like arabinogalactan proteins (FLAs) are a subclass of arabinogalactan proteins (AGPs) that have, in addition to predicted AGP-like glycosylated regions, putative cell adhesion domains known as fasciclin domains. (
  • In other eukaryotes (e.g. fruitfly [ Drosophila melanogaster ] and humans [ Homo sapiens ]), fasciclin domain-containing proteins are involved in cell adhesion. (
  • Despite the deduced proteins having low overall similarity, sequence analysis of the fasciclin domains in Arabidopsis FLAs identified two highly conserved regions that define this motif, suggesting that the cell adhesion function is conserved. (
  • This led us to study the role of two key focal adhesion proteins, focal adhesion kinase (FAK) and paxillin, in GSIS. (
  • These early adhesions have a consistent size of 100 nanometres, are made up of a cluster of around 50 integrin proteins and are the same even when the surrounding surface is hard or soft. (
  • Once the cell forms these early adhesions on soft or hard surfaces, it can use talin and other mechanosensitive proteins to develop force. (
  • A prosthesis is formed from a biocompatible material having one or more associated cell adhesion stimulating proteins. (
  • 6. The medical article of claim 4 wherein the at least one cell adhesion stimulating protein comprises a plurality of structural proteins. (
  • Tissue inhibitors of metalloproteinases (TIMPs) regulate the ECM turnover through negative regulation of matrix metalloproteinases (MMPs), which degrade the ECM structural proteins. (
  • Loss of TIMP2 resulted in a marked reduction of integrin β1D levels and compromised focal adhesion kinase phosphorylation, resulting in impaired adhesion of cardiomyocytes to ECM proteins, laminin, and fibronectin. (
  • 3 - 7 Matrix metalloproteinases (MMPs) degrade ECM proteins, whereas their proteolytic activity is kept in check by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). (
  • Cell-'Extra-Cellular Matrix' (ECM) adhesions also form mechanical and chemical linkages, but the connection occurs between cellular-matrix and the extra-cellular matrix through a plethora of adhesive proteins that form cohesive functional units. (
  • It often takes the clinical experience of physicians trained in the evaluation of pain to know when surgical treatment of adhesions is likely to be helpful, and when it is not. (
  • Learn more about our treatment for surgical adhesions . (
  • Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic polymeric material prior to manipulation of the tissue during surgery. (
  • Small bowel obstruction (intestinal blockage) due to adhesions may become a surgical emergency. (
  • The global surgical hemostats, internal tissue sealants and adhesion barriers market is set to cross US$ 5 Billion by 2024, expanding at a CAGR of over 8% during the next eight years. (
  • However, this steep increase in overall surgical procedures will not necessarily cover-up for the complications associated with adhesion and internal tissue sealants surgeries, as advanced minimally invasive surgical procedures have higher efficiency with reduced size and severity of surgical wounds. (
  • Moreover, increasing focus on developing advanced surgical sealants and adhesion barriers owing to the inadequacy of hemostatic products such as oxidized regenerated cellulose based and gelatin based hemostats that are eventually reaching limitation. (
  • Adhesion between vital tissues has heretofore presented a serious problem inthe surgical field. (
  • When neural spine and spinal cord are removed dorsally by a surgical operation in a vertebral canal cavity in treating myeloma, hernia of intervertebral or adhesive spinal meningitis, it is necessary to prevent adhesion to the body wall. (
  • Tissue sampling was performed 1, 2, 4 and 6 days after surgical de-tensioning of the tendon construct. (
  • On the basis of product, the biosurgery is broadly segmented into bone-graft substitutes, soft-tissue attachments, hemostatic agents, surgical sealants and adhesives, adhesion barriers, and staple-line reinforcement agents. (
  • Tendon adhesions are one of the most concerning complications after surgical repair of flexor tendon injury. (
  • However, as a result of an inflammatory response at the surgical site, and the loss of physical separation, local tendon adhesions, as one of the most concerning complications in tendon repair, may form between the tendons and the surrounding sheath [ 3 ]. (
  • Abdominal adhesions (or intra-abdominal adhesions) are most commonly caused by abdominal surgical procedures. (
  • Small bowel obstruction (SBO) is a significant consequence of post-surgical adhesions. (
  • Obstruction may occur 20 years or more after the initial surgical procedure, if a previously benign adhesion allows the small bowel to twist spontaneously around itself and obstruct. (
  • A meta-analysis in 2012 came to the conclusion that there is only little evidence for the surgical principle that using less invasive techniques, introducing fewer foreign bodies, or causing less ischemia reduces the extent and severity of adhesions in pelvic surgery. (
  • Surgical techniques such as laparoscopic surgery and microsurgery reduce the risk of adhesion formation, but do not eliminate it entirely. (
  • Further, post-surgical adhesions cause up to 74% of bowel obstructions and are responsible for 20-50% of chronic pelvic pain. (
  • Live imaging of actin, myosin, and collagen in control acini revealed adhesions that deformed individual collagen fibrils and generated large traction forces, whereas Dia1-depleted acini exhibited unstable adhesions with minimal collagen deformation and lower force generation. (
  • Scar tissue is made up of collagen fibres. (
  • Mechanical loading of tendon cells results in an upregulation of mechanotransduction signaling pathways, cell-matrix adhesion and collagen synthesis, but whether unloading removes these responses is unclear. (
  • Cell adhesion to collagen and fibronectin as well as cell surface integrin expression were examined. (
  • These cells showed increased expression of α1, α4, and β1 integrins, and exhibited higher adhesion rates to fibronectin and collagen. (
  • If this is allowed to happen, tissue repair cells such as macrophages , fibroblasts , and blood vessel cells penetrate into the fibrinous adhesion and lay down collagen and other matrix substances to form a permanent fibrous adhesion. (
  • Yet, staurosporine induced Akt and Erk activation on H295R cells: the adhesion on type V collagen didn't modify Akt activation, while determined a dramatic inhibition of Erk activation. (
  • The described data demonstrate that the adhesion to type V collagen specifically increases the responsiveness of ACC cells to staurosporine-induced apoptosis and that this is probably obtained through the inhibition of Erk activation. (
  • In a recent study, Jooyoung Lee, Boa Song and co-workers at the Center for Biomaterials and the Department of Polymer Engineering in the Republic of Korea studied the impact of polymer chain flexibility on cell adhesion, with a variety of hydrogel constructs composed of the natural polymers collagen and fibrin. (
  • b,c) Adhesion of HUVEC cells on collagen and fibrin gels onto top surfaces of 2D hydrogel-coated plates (b) and bulk hydrogel (c), which is measured by CCK-8 assay 2 hrs after seeding. (
  • proposed a new, semi-flexible model-based analysis to understand cell adhesion to hydrogels using the well characterized collagen and fibrin polymers. (
  • In the experimental setup, the scientists prepared a variety of collagen and fibrin constructs, to test cell adhesion without gravity effects. (
  • They measured the rate of cell adhesion on diverse concentrations of collagen and fibrin hydrogels in 2-D, and quantified cell adhesion using the cell counting kit 8 (CCK-8). (
  • Collagen specifically affects the cell adhesion rate or the morphology of the cells to be adhered to the support. (
  • 5. The medical article of claim 4 wherein the cell adhesion stimulating protein comprises a structural protein selected from the group consisting of gelatin, collagen, fibronectin, vitronectin and laminin. (
  • Addition of GCM promoted the adhesion of PC12 cells specifically to collagen-coated tissue culture dish. (
  • Labeling of the endothelial cells in different normal tissues with intercellular adhesion molecule-1, P-selectin, and MUC-18 was heterogeneous both in terms of vessel size and strength of staining. (
  • The modification slightly increased the wettability, which might explain the decrease in or undetectable adsorption of adhesive protein shown by QCM-D. Initial cell studies showed that adhesion of human endothelial cells is enhanced when the BC hydrogel is modified with XG-GRGDS. (
  • These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (
  • L1-deficient DCs were impaired in adhesion to and transmigration through monolayers of either lymphatic or blood vessel endothelial cells, implicating L1 in transendothelial migration of DCs. (
  • Both antigens were detected in epithelial tissues, but they showed distributions that were distinct from each other. (
  • The antigen recognized by HECD-1 was expressed in almost all epithelial tissues, while distribution of the other one recognized by NCC-CAD-299 was restricted to the basal or lower layers of stratified epithelia in which both antigens were coexpressed. (
  • In this study, we isolated and characterized a chromosomal locus of Helicobacter pylori previously identified by transposon shuttle mutagenesis as being involved in the adhesion of the pathogen to gastric epithelial cells. (
  • Here, we explore the potential use of cryo-ET of vitrified frozen sections (VFSs) for imaging cell adhesions in chicken smooth muscle and mouse epithelial tissues. (
  • Site-directed electroporation to additional, discrete somite regions, further reveals that N-cadherin-mediated adhesion is necessary for maintaining the epithelial configuration of all dermomyotome domains while promoting the onset of Myod transcription and the translocation into the myotome of myofibers and/or of Pax-positive progenitors. (
  • Epithelial tissue consists of cells that form membranes that cover and line the body surface and cavities, and cells that form glands that secrete hormones and other substances. (
  • It also promotes cell adhesion through interaction with fibronectin and facilitates formation of fibronectin-integrin complexes. (
  • Seven compounds showed more than 50% inhibition of cell adhesion at a concentration of 25 μmol/L. A follow-up fluorescence polarization study revealed that one compound in particular (ITP-79) inhibited binding of a TG2 peptide to a 42-kDa fragment of fibronectin in a dose-dependent manner. (
  • By using knockdown and knock-in experiments, we showed that the enzyme enhances β1-integrin-mediated ovarian cancer cell adhesion to fibronectin ( 4 ). (
  • These findings support the concept that inhibitors of the TG2-FN interaction will effectively disrupt cell adhesion to fibronectin. (
  • A solid-phase adhesion assay was carried out for all 120 compounds and identified several candidates that effectively inhibited cancer cell adhesion to fibronectin. (
  • At the same time, the adhesion of H295R cells on polylysine, matrigel, lamimin, fibronectin, and type I-III collagens didn't modify staurosporine-induced apoptosis. (
  • Using SH-SY5Y cells as an experimental model, we found that supporting with PC12 CM enhanced HA function in SH-SY5Y cell proliferation and adhesion. (
  • Through RP-nano-UPLC-ESI-MS/MS analyses, we identified increased expression of HSP60 and RanBP2 in SH-SY5Y cells grown on HA-modified surface with cotreatment of PC12 CM. Moreover, we also identified factors that were secreted from PC12 cells and may promote SH-SY5Y cell proliferation and adhesion. (
  • A total of 120 compounds were acquired and tested in cell culture-based assays for inhibition of ovarian tumor cell adhesion and proliferation. (
  • CCN2 interacts with integrin α 5 β 1 on pancreatic stellate cells (PSC) in which it stimulates fibrogenesis, adhesion, migration, and proliferation. (
  • During retinal development, cell-cell and cell-ECM interactions are necessary for cell adhesion, migration, proliferation, and differentiation and are likely to be critical in establishing the highly organized architecture of the retina. (
  • Increased degradation of the thermoplastic support structure and proliferation of the cells not only in the hydrogel, but also on the thermoplastic phase, indicates the potential of this novel material combination for biofabricating 3D tissue engineering scaffolds. (
  • inducing the colonization and proliferation of viable cells to reduce or inhibit thrombosis by adhering a cell adhesion stimulating protein to a ceramic material, the cell adhesion stimulating protein being selected from the group consisting of VEGF, fibroblast growth factor, and combinations thereof. (
  • These findings suggest that although MIC-1 has no effect on cell proliferation, it reduces cell adhesion and consequently induces cell detachment. (
  • Activins are widely distributed in tissue and have various biologic activities, i.e., cellular proliferation, angiogenesis, inflammation, and embryogenesis [ 5 - 9 ]. (
  • Lee BH, Ruoslahti E. Alpha5beta1 integrin stimulates Bcl2 expression and cell survival through Akt, focal adhesion kinase and Ca2+/calmodulin dependent protein kinase IV. (
  • The integrin-mediated physical connection between cell and ECM is not simply mechanical but also results in the induction of outside-in integrin-dependent signaling pathways, beginning with tyrosine phosphorylation of the key cytoskeletal protein focal adhesion kinase (FAK) ( 12 ). (
  • The VECTABOND® Reagent for Tissue Section Adhesion is designed to significantly increase the adherence of both frozen and paraffin-embedded tissue sections and cell preparations to glass slides and coverslips. (
  • On the other hand, the antigen recognized by HECD-1 showed essentially the same tissue distribution pattern as E-cadherin in the mouse, suggesting that this molecule is the human homologue of E-cadherin. (
  • intercellular adhesion molecule-1 (CD54), E-selectin (endothelial cell adhesion molecule-1), vascular cell adhesion molecule-MUC-1, P-selectin (platelet activation-dependent granule to external membrane protein, CD62) and MUC-18 using either the APAAP immuno-alkaline phosphatase or an immunoperoxidase method. (
  • Vascular cell adhesion molecule-1 and E-selectin were largely absent. (
  • Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. (
  • These results indicate that Necl-1 is a neural-tissue-specific Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which potentially has membrane-associated guanylate kinase subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites. (
  • Schenkel AR, Chew TW, Muller WA (2004) Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains. (
  • Cell surface modulation of the neural cell adhesion molecule resulting from alternative mRNA splicing in a tissue-specific developmental sequence. (
  • The neural cell adhesion molecule N-CAM is an intrinsic membrane glycoprotein that is expressed in the embryonic chicken nervous system as two different polypeptide chains encoded by alternatively spliced transcripts of a single gene. (
  • it first appeared as neurons began to extend neurites and to express the neuron-glia cell adhesion molecule (Ng-CAM) and it was restricted to definite layers in laminar tissues such as the retina and cerebellum. (
  • of Human Junctional Adhesion Molecule C (EAW67820). (
  • C-REAFLNGSDGHKRKE , corresponding to C terminal amino acids 370-384 of Human Cell adhesion molecule 4 (Q8NFZ8). (
  • The adhesion molecule L1, which is extensively characterized in the nervous system, is also expressed in dendritic cells (DCs), but its function there has remained elusive. (
  • Cell-cell adhesion complexes are macromolecular adhesive organelles that integrate cells into tissues. (
  • Born from a female physical therapist's need to relieve her own debilitating adhesion pain, our therapists have developed an effective method to decrease adhesive bonds - returning the body to an earlier state of pain-free mobility and function. (
  • Our results support a model in which regulation of adhesive surface dynamics and cortical tension by extrinsic signaling modifies the thermodynamic landscape to promote organization of daughter cells in the context of the three-dimensional growth plate tissue. (
  • In the case of adhesive capsulitis of the shoulder (also known as frozen shoulder), adhesions grow between the shoulder joint surfaces, restricting motion . (
  • The adhesive compositions have greatly reduced adhesion to skin, not forming strong skin bonds for at least 30 seconds, in contrast to conventional cyanoacrylate adhesive compositions which form, within in about one second bonds strong enough to tear skin. (
  • This is likely to be mediated by conformational effects because domain EIIIB alone neither exhibited any adhesive activity nor competed in inhibiting adhesion to fragments #7-10. (
  • The invention discloses a cell culture support which provides for the adhesion and culturing of one or more adhesive cells using a photoresist in which to provide a particular patterned design on a surface of the support. (
  • When tested on a wet hydrophilic surface, geckos produced a significantly lower shear adhesive force (5.4 ± 1.33 N) compared with a dry hydrophilic surface (17.1 ± 3.93 N). In tests on an intermediate wetting surface and a hydrophobic surface, we found no difference in shear adhesion between dry and wet contact. (
  • 14. The method of claim 13 wherein the adhering of the cell adhesion stimulating protein to the ceramic material is performed using an adhesive. (
  • Likewise, adhesive properties (adhesion strength and adhesive plaque gross morphology) were not affected by reduced pH. (
  • Pelvic adhesions may involve any organ within the pelvis, such as the uterus, ovaries, Fallopian tubes, or bladder, and usually occur after surgery, such as after C-section or hysterectomy . (
  • Pelvic inflammatory disease ( PID ) results from an infection (usually a sexually transmitted disease ) that frequently leads to adhesions in and around the Fallopian tubes. (
  • Fallopian adhesions can lead to infertility and increased incidence of ectopic pregnancy in which a fetus develops outside the uterus. (
  • I had my (l) fallopian tube removed, along w/scar tissue, & adhesions during laparoscopy surgery. (
  • Had cyst on ovary removed, cut of one Fallopian tube, pelvic adhesions removed and endometriosis by laparoscopic surgery. (
  • Doctors associate signs and symptoms of adhesions with the problems an adhesion causes rather than from an adhesion directly. (
  • The tissue develops when the body's repair mechanisms respond to any tissue disturbance, such as surgery, infection, trauma , or radiation . (
  • Conserved mechanisms by which tissues initiate motility into their surroundings are not known. (
  • The mechanisms by which these leukocytes traverse the endothelial cell layer to reach the underlying tissue, a process called diapedesis, are largely unknown. (
  • Imhof BA, Aurrand-Lions M (2004) Adhesion mechanisms regulating the migration of monocytes. (
  • By electron microscopy we elucidated the different mechanisms of colonization and invasion of a stratified epithelium, including adherence to surface cells, invasion and eventual release from infected cells, disintegration of intercellular connections followed by paracellular tissue infiltration, invasion of deeper cells, and initiation of cellular destruction and exfoliation resulting in thinning of the mucosa. (
  • The impairment of reproductive performance from adhesions may happen through many mechanisms, all of which usually stem from the distortion of the normal tubo-ovarian relationship. (
  • Most adhesions are painless and do not cause complications. (
  • cause significantly higher post-operative complications (leaks, wound infections, haemorrhages) in people with adhesion-related perforations. (
  • However in some patients adhesions cause severe complications such as chronic pain, obstruction and strangulation of the bowel. (
  • Accurate imaging of adhesions would be of benefit avoiding adhesion related complications at repeated laparotomy or laparoscopy. (
  • Adhesions can form anywhere in the body as the first step in the healing process after an infection, inflammation, surgery or trauma. (
  • Inflammation and infections are frequent causes of tissue damage and adhesions form as healing occurs. (
  • Leukocyte emigration into inflamed tissues is among the most intensely pursued topics in the field of inflammation. (
  • This often causes inflammation and causes fibrin deposits onto the damaged tissues. (
  • Scar tissue is most often caused by surgery or injury, but can also come about after inflammation, where the tissue has had to scar over to heal. (
  • New research has shown that with many chronic tendonitis and chronic soft tissue cases, the problem does not even involve inflammation at all, and that's why ant-inflammatory treatments don't provide long-term relief. (
  • While inflammation, infection and even radiation can cause adhesions , it is surgery that is the number one cause of this disorder. (
  • According to the "classical paradigm" of adhesin formation, the pathogenesis starts with inflammation and activation of the coagulation system which causes fibrin deposits onto the damaged tissues. (
  • In many cases, the production or activity of these enzymes are compromised because of inflammation following injury or infection, however, and the fibrinous adhesion persists. (
  • Mechanical problems can occur in the body due as a result of adhesions that form when the body tries to compensate after the original injury, surgery or infection. (
  • Adhesion-related disorder (ARD) is a group of symptoms that may occur as a result of adhesions. (
  • The disease leukocyte adhesion deficiency type 1 (LAD1) affects white blood cells. (
  • Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (
  • This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (
  • This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (
  • During development cells interact mechanically with their microenvironment through cell-cell and cell-matrix adhesions. (
  • As tissues become more established, adhesions play a major role integrating cells with the mechanics of their local environment. (
  • Adhesions may serve as both a molecular-specific glue, holding defined populations of cells together, and as a lubricant, allowing tissues to slide past one another. (
  • Basement membrane sliding followed by targeted adhesion represents a new mechanism for creating precise basement membrane breaches that can be used by cells to break down compartment boundaries. (
  • In many cases, branching morphogenesis is initiated when growth factors stimulate a few individual cells within the developing tissue to extend protrusions that adhere to the surrounding ECM. (
  • In both developmental and pathological contexts, shape changes undertaken by tissues rely on the coordination of cell motility and cell adhesions to neighboring cells and the ECM. (
  • An outstanding question is how tissues transition from compact structures dominated by cell-cell adhesions to invading cohorts of cells that interact extensively with their ECMs. (
  • Adhesion studies were performed in the presence of EDTA, divalent cations, anti-integrin α 5 β 1 antibodies, CCN2 synthetic peptides, or heparin, or after pretreatment of the cells with heparinase, chondroitinase, or sodium chlorate. (
  • CCN2 4 supported PSC adhesion or migration were blocked by anti-integrin α 5 β 1 antibodies or by treatment of cells with heparinase or sodium chlorate. (
  • Adult mesenchymal stem cells (MSCs) are an important resource for tissue growth, repair, and regeneration. (
  • Cells with depleted CAV-1 expression showed decreased cell surface integrin expression and slower adhesion to different substrates. (
  • Endogenous or exogenous stem cells, such as adult mesenchymal stem cells (MSCs), are an attractive cell source to utilize for effective restoration of tissue function by cell-driven tissue synthesis. (
  • In the field of tissue engineering, it is known that cells sense the mechanical properties of their environment, however some materials, such as Sylard 184 PDMS (poly(dimethylsiloxane)), have failed to elicit such response. (
  • The inclusion of domain EIIIA led to a decrease in the adhesion of cells and those that adhered did not spread well. (
  • Local gene missexpression confirms that N-cadherin-mediated adhesion is sufficient to promote myotome colonization, whereas its absence drives cells towards the subectodermal domain, hence coupling the asymmetric distribution of N-cadherin to a shift in mitotic orientation and to fate segregation. (
  • Thus, hydrogels are also chosen for the one-step additive manufacturing of 3D constructs containing homogenously distributed cells, which mimic the complex structure of tissues [ 6 , 7 ]. (
  • More recently, Dr. Stacey has been appointed as a Lecturer of Immunology, at the University of Leeds where his laboratory focuses on adhesion‑GPCRs and role of myeloid cells in human disease. (
  • Deciphering the universal nature of adhesion formation may reveal how tumour cells sense and migrate on surfaces of different rigidity, which is a hallmark of metastasis, the devastating ability of cancer to spread throughout the body. (
  • Cells interact with their environment through protein complexes called focal adhesions. (
  • Although cells can form focal adhesions on both soft and hard surfaces, how they assemble on surfaces of such different rigidity is still a mystery. (
  • By growing cells on either hard glass or fluid artificial membranes coated with RGD, and observing adhesion formation with super-resolution microscopy, a team of MBI scientists led by Dr Rishita Changede and Professor Michael Sheetz was able to investigate the molecular origins of adhesion formation on surfaces of different rigidity. (
  • Remarkably, they discovered that cells growing on soft or hard surfaces form adhesions in the exact same way. (
  • This study reveals that cells form early adhesions from integrin clusters as a first response to their environment, and that these universal, modular units of adhesion assemble without the need for external stimuli from the surrounding surface. (
  • CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (
  • In a degenerative tendon, healthy tendon cells are replaced by fibrotic (scar) tissue. (
  • We adapted the biophysical properties of hyaluronic acid-based hydrogels to support the differentiation of white adipose tissue-derived multipotent stem cells (ADMSCs) into lipid-accumulating, UCP1-expressing beige adipose tissue. (
  • Brown adipose tissue (BAT) and inducible brown-like cells in white adipose tissue (WAT), currently referred to as beige or brite adipocytes ( 1 ), possess the innate ability to dissipate metabolic energy as heat through nonshivering thermogenesis. (
  • Viable cells can be adhered in vivo or in vitro to the biocompatible material with the cell adhesion stimulating protein. (
  • Cells with similar properties can be categorized as part of the same tissue . (
  • Muscle tissue consists of cells specialized for contraction. (
  • Nervous tissue consists of neurons, cells specialized for the conductance and transmission of electrochemical impulses, as well as support cells (review Tutorial on Membrane Potential, Ion Transport and Nerve Impulse ). (
  • The antiapoptotic gene metallothionein 1E and cell adhesion genes RhoE and catenin δ1 were down-regulated by more than 2-fold by MIC-1, suggesting that they were, at least in part, responsible for the observed changes in the behavior of DU-145 cells. (
  • The INHBB knockdown (shINHBB) cells promoted cellular adhesion and suppression of cellular invasiveness and migration. (
  • Although exogenous activin B promotes cellular adhesion, migration, and invasiveness activities in endometrial cancer cells [ 14 , 15 ], the detailed functions of activin B in OSCCs have not been reported. (
  • Promotion of cell-substratum adhesion of clonal rat pheochromocytoma cells (PC12) by factors contained in glioma-conditioned medium (GCM): separation of two active factors contained in GCM. (
  • The effects of GCM on the cell-substratum adhesion of PC12 cells, which is an early event required for the neurite outgrowth, were investigated. (
  • The GCM-promoted adhesion of PC12 cells was prevented by the treatment of the cells with cytochalasin B, concanavalin A and glycosidase mixture suggesting the contribution of microfilaments and cell surface carbohydrates in the cell adhesion. (
  • around 40,000 had the abilities to induce the neurite outgrowth and to enhance the choline acetyltransferase activity in addition to the ability to promote the adhesion of PC12 cells. (
  • Adhesion among neural cells of the chick embryo. (
  • Cell-cell adhesions provide chemical and mechanical connections between adjacent cells. (
  • Cell migration is generally classified with four cell processes: Leading edge protrusion Adhesion formation Cell body translation Trailing edge adhesion detachment The coordination of these processes allows for the efficient migration of cells through their environment. (
  • Most often, adhesions are the result of previous surgery, but some can occur following pelvic infection, and many times they accompany more severe stages of endometriosis. (
  • Like scars that occur on the outside, adhesions are simply scars that form inside our bodies. (
  • Adhesions may occur on the surface of our bodily structures or deep within them. (
  • Adhesions can occur after surgery. (
  • Although adhesions can occur anywhere, the most common locations are within the abdomen, the pelvis, and the heart. (
  • Abdominal adhesions also occur in a small number of people who have never had surgery. (
  • Large gaps in basement membrane occur at sites of cell invasion and tissue remodelling in development and cancer. (
  • Scar tissue can occur on the surface of the body but also occurs inside the body. (
  • Where do adhesions occur? (
  • Adhesions can occur anywhere in the body. (
  • Lymphocyte attachment to porcine endothelium was primarily L-selectin mediated, whereas β 2 integrin and VCAM-1/very late Ag-4 (VLA-4) interactions promoted static adhesion. (
  • Mice generated by gene targeting to lack CCR2 exhibit normal leukocyte rolling but have a pronounced defect in MCP-1-induced leukocyte firm adhesion to microvascular endothelium and reduced leukocyte extravasation. (
  • In particular, transendothelial migration is of paramount importance during DC-induced immune response because DCs need to cross both the blood vessel wall, to move from the bloodstream to the peripheral tissue, and the lymphatic endothelium, to reach the lymph nodes via the lymphatic circulation ( 6 ). (
  • L1-deficient DCs derived from these mice were impaired in both adhesion to the endothelium and in transendothelial migration. (
  • Adhesions may appear as thin sheets of tissue similar to plastic wrap or as thick fibrous bands. (
  • In extreme cases, adhesions may form fibrous bands around an entire segment of the intestine. (
  • Unfortunately, diagnosing the presence of pelvic adhesions is difficult. (
  • Pelvic adhesions are a form of abdominal adhesions in the pelvis . (
  • Does this sound like pelvic adhesions, ovarian cyst or endometriosis pain? (
  • This 'pull' often creates mechanical irritation, generating more adhesion formation. (
  • In fact, surgery to remove adhesions has itself been implicated as a major cause of adhesion formation. (
  • Baxter, Vienna, Austria) on adhesion formation to cPTFE (condensed polytetrafluoroethylene) meshes (Motif®Meshes, MM, Proxy Biomedical, Ireland) as well as on tissue integration of these implants in experimental IPOM repair in rats. (
  • Conclusions FS improves the tissue integration, reduces early adhesion formation to cPTFE implants and allows reduction of perforating fixation devices in experimental IPOM repair. (
  • A common problem surgeons face when performing repeat operations, however, is the formation of adhesions. (
  • Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation. (
  • The biology of adhesion formation in the peritoneal cavity. (
  • Using a chicken model, we have examined the effects of a small interfering RNA (siRNA) targeting ERK2 delivered by a lentiviral system on tendon adhesion formation with an adhesion scoring system, histological assessment, and biomechanical evaluation. (
  • These results show that the lentiviral-mediated siRNA system is effective in preventing tendon adhesion formation but not to tendon healing, and may be used for tendon repair after confirmation and improvement by future detailed studies. (
  • In addition, the inhibitory effects of pharmacologic agents, such as 5-fluorouracil and hyaluronic acid [ 3 , 7 , 8 ], on adhesion formation have been investigated as well. (
  • Therefore, it is necessary to develop novel practical approaches to clinically prevent adhesion formation. (
  • Adhesion formation post-surgery typically occurs when two injured surfaces are close to one another. (
  • [3] These data suggested that two different stimuli are necessary for adhesion formation: a direct lesion of the mesothelial layers and a solid substrate foreign body (FB). (
  • The formation of adhesions is part of a normal wound healing. (
  • This disease is characterized by recurrent bacterial infections, impaired wound formation, and other aberrations of adhesion-dependent functions. (
  • Intriguingly, altering the density of the RGD coating also had no effect on the formation of early adhesions. (
  • Formation of early adhesions was also assisted by rapid recruitment of the mechanosensor protein, talin. (
  • Little is known about how variations in the environment affect adhesion and shell formation processes in barnacles. (
  • Here, we assessed if a reduction in seawater pH, at levels predicted within the next 200 years, would alter physiology, adhesion, and shell formation in the cosmopolitan barnacle Amphibalanus (=Balanus) amphitrite . (
  • Unfortunately, during the informed consent process prior to surgery, most patients are not informed of the risk of adhesion formation. (
  • Specifically, it has been found that adhesions are involved in tissue development, plasticity, and memory formation within the central nervous system (CNS), and may prove vital in the generation of CNS-specific therapeutics. (
  • Cadherin based migration is essential to tissue organization in the central nervous system, specifically in cortical layer formation. (
  • A more recent study suggested that the formation of "fibrinous" adhesions is preceded by the aggregation of cavity macrophages, that can act like extravascular platelets in the abdominal cavity. (
  • The sequence GVCTDGR in module 4 mediated the binding between CCN2 4 and integrin α 5 β 1 as well as CCN2 4 mediated PSC adhesion and migration. (
  • The major protein in the focal adhesion complex is integrin, which spans the cell membrane, forming a link between the internal skeleton of the cell and external surface. (
  • Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation, Developmental Cell (2015). (
  • Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts. (
  • OBJECTIVE To determine whether normal peritoneal and adhesion fibroblasts express tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI-I) and whether their expression is regulated by oxygen. (
  • PATIENT(S) Cultures of human fibroblasts established from peritoneal and adhesion tissues. (
  • A dynamic cell adhesion surface regulates tissue architecture in growth plate cartilage. (
  • Findings from this study will contribute to the understanding of how cholesterol/CAV-1/caveolae regulates aspects of the cell membrane important to cell adhesion, substrate sensing, and microenvironment interaction. (
  • Results All 8 MMs without FS sealing elicited severe (grade III) adhesions, whereas fibrin sealed MM were rated mild in 1, moderate in 5 and severe in 2 cases. (
  • [2] The fibrin then connects the two adjacent structures where damage of the tissues occurred. (
  • The fibrin acts like a glue to seal the injury and builds the fledgling adhesion, said at this point to be "fibrinous. (
  • Further, suturing of ruptured tendons and tendon transfer would sometimes fail because of the postoperative adhesion of the tendon to the scar in the skin. (
  • Usually, tendon adhesions bind the flexor tendons to each other or to their sheath, which restricts normal tendon gliding and consequently leads to poor functional recovery. (
  • There is a lot of new research being done on this and other chronic problems with soft tissue and tendons. (
  • As the body's tissues heal and adhesions are formed, the tissues begin to shrink and pull, which results in restricted movement of the area. (
  • For example, a fall on the hip or tailbone can cause adhesions to form as the body's first healing response to that trauma. (
  • Adhesions form as a natural part of the body's healing process after surgery in a similar way that a scar forms. (
  • Scar tissue is the body's own mechanism for healing areas which have been physically cut or torn in the body. (
  • Postoperative adhesions as a consequence of pelvic surgery. (
  • Taking into account that magnetotherapy and magnetostimulation are not applicable in primary care, family doctors should consider a consultation with a physical therapy specialist in order to prescribe a cycle of physical treatment with the use of these methods in the case of such patients with drug-resistant abdominal pain caused by diagnosed postoperative peritoneal adhesions. (
  • If an organ undergoes repair and comes into contact with another part of itself, or another organ, scar tissue may form to connect the two surfaces. (
  • Immunohistochemical experiments indicated that only the sd chain was expressed on cell surfaces of non-neural tissues throughout embryonic development. (
  • Finally, in tests on polytetrafluoroethylene (PTFE), we found that geckos clung significantly better to wet PTFE (8.0 ± 1.09 N) than dry PTFE (1.6 ± 0.66 N). To help explain our results, we developed models based on thermodynamic theory of adhesion for contacting surfaces in different media and found that we can predict the ratio of shear adhesion in water to that in air. (
  • In principle, the interaction of gecko feet with such surfaces may have a significant effect on adhesion, yet gecko research has only just begun to tackle such questions ( 26 ⇓ - 28 ). (
  • Additionally, natural surfaces are likely to become wet (especially in the tropics) and dirty, potentially reducing adhesion. (
  • The pelvic infection moves up to involve the upper abdomen and when liver encapsulation occurs, perihepatic adhesions result. (
  • Almost everyone who has surgery on the abdomen gets adhesions. (
  • The term "adhesion" is applied when the scar extends from within one tissue across to another, usually across a virtual space such as the peritoneal cavity . (
  • Adhesions can also obstruct access to the peritoneal cavity and complicate reoperations. (
  • We review the biophysical principles and experimental tools used to study adhesion so that we may aid efforts to understand how adhesions guide these movements and integrate their signaling functions with mechanical function. (
  • Tissue Regeneration from Mechanical Stretching of Cell-Cell Adhesion. (
  • The mechanotransduction responses from these different cell types will be discussed with an emphasis on their biophysical transformations during mechanical stretching and the cross talk between the cell-cell and cell-ECM adhesion complexes. (
  • Therapeutic aspects of mechanical stretching are reviewed considering these cellular responses after the application of mechanical forces, with a focus on wound healing and tissue regeneration. (
  • Impact Statement Mechanical stretching has been proposed as a therapeutic option for tissue regeneration and wound healing. (
  • This review serves the mechanobiology community by shifting the focus of mechanical stretching effects from cell-ECM adhesions to the less examined cell-cell adhesions, which we believe play an equally important role in orchestrating the response pathways. (
  • Our results highlight the importance of surface adhesion and the resulting changes in contact area, and sample microstructural heterogeneity, in particular for the mechanical characterisation of ultra-soft substrates at the nano- to micro-scale. (
  • A number of biological or synthetic materials, such as amniotic membrane, Seprafilm and polytetrafluoroethylene membrane, have been evaluated as mechanical barriers to prevent tendon adhesions [ 4 - 6 ]. (
  • Hydrogels, however, lack mechanical integrity for use in bone or cartilage tissue engineering [ 8 , 9 ]. (
  • In tumors such as ovarian cancer, in which cellular adhesion to the matrix plays a critical role in the establishment of metastases ( 8 ), such inhibitors may prevent cancer dissemination. (
  • However, nearly all surgeries cause adhesions to form. (
  • Demand for adhesion barriers surgeries is also poised to grow at a handsome pace, reflecting a CAGR of 9.2% between 2016 and 2024. (
  • Scar tissue you can't see may form due to internal wounds, surgeries, or underlying diseases. (
  • Such is the case with knee or spinal scar tissue, as well as scar tissue formed following surgeries of the face, or from medical procedures like hysterectomies . (
  • Adhesions form to help the body heal from surgery, infection or trauma. (
  • Experimental infection of native human ureteral tissue with Neisseria gonorrhoeae: adhesion, invasion, intracellular fate, exocytosis, and passage through a stratified epithelium. (
  • In morphological terms, this tissue closely resembles parts of the urethral proximal epithelium, a site of natural gonococcal infection. (
  • When it seems likely that adhesions may be important, then a laparoscopy can be done to see them, and the adhesions can often be removed during the same laparoscopic procedure. (
  • First, laparoscopic treatment of adhesions is most safely and effectively done by laparoscopic surgeons specially trained and experienced in performing this type of surgery. (
  • Impact of intraperitoneal pressure and duration of surgery on levels of tissue plasminogen activator and plasminogen activator inhibitor-1 mRNA in peritoneal tissues during laparoscopic surgery. (
  • Necl-1 showed Ca2+-independent homophilic cell-cell adhesion activity. (
  • When tested in a centrifugal cell adhesion assay, fragments including domain EIIIB resisted the detaching forces and stayed adhered. (
  • Two active factors contained in GCM were separated by either gel filtration or chromatofocusing using the cell adhesion assay as an index. (
  • Researchers believe the hydrogel they have developed may offer a potential solution, one that creates a barrier to prevent adhesion between heart tissue and surrounding tissue. (
  • Thus, the conservative approach requires us to examine a person's history of healing events to determine whether adhesions are causing the pain or dysfunction. (
  • Another possibility is that a severe burn or a deep wound can eventually affect underlying bones and joints, leading to subsequent pain at the site of the scar tissue. (
  • Scar tissue from burns, cuts, and severe acne may respond to dermabrasion or laser therapy. (
  • Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (
  • A syndrome characterized by congenital cataracts and severe brain abnormalities apparently resulting from hemorrhagic destruction of the brain tissue, including the cerebral white matter and basal ganglia. (
  • After adhesions are established, the cantilever/cell is withdrawn from the substrate and the bonds that have been formed sequentially break. (
  • This ground-breaking technique, known as single cell force spectroscopy (SCFS), measures the interaction forces between a living cell attached to a cantilever and a target cell, functionalized substrate, tissue or biomaterial. (
  • An exhaustive study examining five decades of surgery showed that more than 90% of patients develop adhesions following open abdominal surgery and 55% to 100% of women develop adhesions after pelvic surgery. (
  • Adhesions are a frequent problem in abdominal surgery. (
  • Potential causes of intestinal obstruction include intestinal adhesions that result after abdominal surgery, colon cancer, diverticulitis, hernias, impacted feces, twisting of the colon (volvulus), and inflammatory bowel diseases such as Crohn's. (
  • Like scars that form on the skin, adhesions are 'internal scars. (
  • How do scars and adhesions respond to treatment? (
  • Scars which are twenty or thirty years old can be treated with great success, as well as internal abdominal adhesions, relieving symptoms several years after they first appeared. (
  • Uncommonly, adhesions can cause blockage of the bowels (intestinal obstruction). (
  • Intestinal adhesions may cause pain due to obstruction due to blocking the passage of intestinal contents such as food or liquid or during exercise or when stretching. (
  • The ex vivo placental perfusion model was modified to study adhesion of infected erythrocytes binding to CSA, endothelial protein C receptor (EPCR) or a transgenic parasite where P. falciparum erythrocyte membrane protein 1 expression had been shut down. (
  • We report here that the ld-specific sequences comprise a single exon in the chicken N-CAM gene and that developmental expression of the ld and sd chains occurs in a tissue-specific fashion, with the ld chain restricted to the nervous system. (
  • Here we report that expression of versican 3′UTR induces organ adhesion in transgenic mice by modulating miR-199a* activities. (
  • Enhanced adhesion by expression of the 3′UTR was confirmed by in vitro assays. (
  • In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (
  • This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (
  • Besides the nervous system, L1 expression has been reported in various normal tissues, ranging from some epithelia to certain lineages of the hematopoietic system, as well as in several tumor types. (