Tissue Adhesives
Cell Adhesion Molecules
Intercellular Adhesion Molecule-1
Focal Adhesions
An anchoring junction of the cell to a non-cellular substrate. It is composed of a specialized area of the plasma membrane where bundles of the ACTIN CYTOSKELETON terminate and attach to the transmembrane linkers, INTEGRINS, which in turn attach through their extracellular domains to EXTRACELLULAR MATRIX PROTEINS.
Vascular Cell Adhesion Molecule-1
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
Bacterial Adhesion
Focal Adhesion Kinase 1
A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
Focal Adhesion Protein-Tyrosine Kinases
Integrins
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Neural Cell Adhesion Molecules
Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)
Cell Movement
Cell Adhesion Molecules, Neuronal
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Fibronectins
Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
E-Selectin
Paxillin
Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.
Cells, Cultured
Endothelium, Vascular
Cadherins
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Antigens, CD18
Platelet Adhesiveness
Antigens, CD29
Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)
Lymphocyte Function-Associated Antigen-1
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Vinculin
Integrin alpha4beta1
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
P-Selectin
Cell Aggregation
Neural Cell Adhesion Molecule L1
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Focal Adhesion Kinase 2
MedlinePlus
Abdominal Cavity
Evaluation of the performance of fertiloscopy in 160 consecutive infertile patients with no obvious pathology. (1/635)
We have defined fertiloscopy as the combination in one investigation of transvaginal hydropelviscopy, dye-test, optional salpingoscopy, and hysteroscopy, performed on an outpatient basis under local anaesthesia or neuroleptanalgesia. We have applied this approach in a routine manner to 160 infertile patients with no obvious pathology. Fertiloscopy was achieved in 154 patients (96.2%). In five patients visualization was not satisfactory because of technical problem or adhesions in the pouch of Douglas. We had one (0.6%) rectal injury, which was treated conservatively. Sixty patients (37.5%) had normal fertiloscopic examination. Endometriosis was discovered in 21 patients (13.1%) post-pelvic inflammatory disease (PID) lesions in 58 cases (36.2%), and subtle abnormalities in 15 cases (9.3%). Salpingoscopy was completed when post-PID lesions were encountered. In 39% of cases only partial examination was possible because of external tubal adhesions, but it was nevertheless sufficient to obtain a good view of the first one-third of the ampulla. In all, 74 patients (46.2%) were referred directly to in-vitro fertilization (IVF) procedures, and so avoided a further laparoscopy. Quality of imaging, accuracy of the pelvic examination in a physiological manner, and safety of the procedure are the main advantages of this minimally invasive technique. Selection of the patients for surgery is therefore enhanced, and indication for IVF is better balanced, avoiding the performance of extensive procedures in patients who should thus benefit from this less traumatic alternative. (+info)Hysteroscopic treatment of severe Asherman's syndrome and subsequent fertility. (2/635)
In a retrospective case report series, we evaluated the efficacy of hysteroscopic adhesiolysis in patients with severe Asherman's syndrome. In 31 patients with permanent severe adhesions, hysteroscopic treatment was performed. In all patients, uterine cavity with at least one free ostial area was restored after one (n = 16), two (n = 7), three (n = 7), and four (n = 1) surgical procedures. All previously amenorrhoeic patients (n = 16) had resumption of menses. Twenty-eight patients were followed-up with a mean time of 31 months (range 2-84). Fifteen pregnancies were obtained in 12 patients and the outcomes were the following: two first trimester missed abortions, three second trimester fetal losses, one second trimester termination of pregnancy for multiple fetal abnormalities and nine live births in nine different patients. Pregnancy rate after treatment was 12/28 (42.8%) and live birth rate was 9/28 (32.1%). In patients 35 years (P = 0. 01). Three patients were lost to follow-up and their results omitted. In nine patients with live births, one Caesarean hysterectomy for placenta accreta and one hypogastric arteries ligation for severe haemorrhage and placenta accreta were performed. Hysteroscopic treatment of severe Asherman's syndrome appeared to be effective for the reconstruction of a functional uterine cavity with a 42.8% pregnancy rate. However, these pregnancies were at risk for haemorrhage with abnormal placentation. (+info)Expanded polytetrafluoroethylene membrane for the prevention of peridural fibrosis after spinal surgery: an experimental study. (3/635)
One of the most common complications of lumbar spine surgery is peridural fibrosis, a fibroblastic invasion of the nerve roots and the peridural sac exposed at operation. Peridural fibrosis may produce symptoms similar to those the patient experienced preoperatively and, if another spinal operation is necessary, may increase the risk of injury at reexposure. In a controlled study in dogs, we assessed the use of expanded polytetrafluoroethylene (ePTFE) as a barrier to postoperative invasion of fibrous tissue into the laminectomy defect. In 14 dogs, a two-level laminectomy was done, at L4-L5 and L6-L7. In 12 dogs, an ePTFE membrane was placed directly over the dorsal surface of the laminectomy defect at L4-L5 and within the defect (over the surface of the dura) at L6-L7. No material was implanted in two dogs (controls). Tissue for histologic studies was obtained from the controls and from ten dogs with the membrane 12 weeks postoperatively. Two dogs with the membrane underwent reoperation. The study found that there was no peridural fibrosis in seven of the ten specimens in which the ePTFE membrane had been placed directly on the dorsal surface of the laminectomy defect, some peridural fibrosis in all specimens in which the membrane had been placed within the defect, and extensive fibrosis in controls. The ePTFE membrane created an excellent plane of dissection for reoperation. No foreign-body reactions to the membrane or membrane-related infections occurred. We conclude that the ePTFE spinal membrane, when properly implanted, is an effective barrier to postsurgical fibrous invasion of the vertebral canal. Clinical studies of use of this material in spinal surgery are warranted. (+info)Expanded polytetrafluoroethylene membrane for the prevention of peridural fibrosis after spinal surgery: a clinical study. (4/635)
Peridural fibrosis developing after laminectomy may cause pain that can necessitate reoperation. Many materials have been used as a barrier to invasion of fibrous tissue into the vertebral canal, but the ideal material has not been found. Various studies in animals have achieved favourable results with an expanded polytetrafluoroethylene (ePTFE) membrane. In a prospective, randomized study, we compared postoperative results in 33 patients who had an ePTFE membrane implanted to cover the defect caused by laminectomy during lumbar spine decompression with the results in 33 patients in whom no material was implanted. At operation, an ePTFE membrane was placed after the decompression procedure to cover the laminectomy defect completely. Systematic clinical and MRI follow-up evaluations of patients with and without the membrane were conducted 3, 6, 12, and 24 months postoperatively. The effect of ePTFE membrane implantation over laminectomy sites on postoperative peridural fibrosis, pain and neurological claudication was assessed. The ePTFE-membrane group had a significantly lower rate of epidural fibrosis on MRI (P<0.0001) and of clinical manifestations of radiculalgia (P = 0.002) compared with the no-material group. Epidural fibrosis that occurred in the ePTFE group was generally less extensive than that in the no-material group. There was no significant difference in the rate of postoperative claudication in the two groups. Significantly more seromas occurred in the ePTFE group (P = 0.0002). There were no infections or other complications in either group. The results showed that placement of an ePTFE spinal membrane over the laminectomy defect produced by lumbar spine surgery provided a physical barrier to invasion of fibrous tissue into the vertebral canal, and patients with the membrane had less postoperative radicular pain. (+info)Adhesion preventive effect of hyaluronic acid after intraperitoneal surgery in mice. (5/635)
Prevention of intraperitoneal adhesion after gynaecological surgery is essential for maintaining postoperative fertility. In this study, the adhesion prevention effect was examined of a hyaluronic acid (HA) solution obtained from the fermentation method and having a molecular weight of 1.9x10(6) with high viscosity. Laparotomy was conducted on female mice 7 weeks old, whose menstrual periods were synchronized by pregnant mare serum gonadotrophin (PMSG) to injure the uterine horn surface. Intraperitoneal adhesions were favourably formed in 91.7% of cases induced with iodine abrasion, compared with 50% induced by electrosurgery. Intraperitoneal administration of HA was evaluated for its effect on the prevention of adhesions made by iodine abrasion. Adhesion prevention effects of HA were observed at concentrations of 0.3, 0.5, 0.75 and 1.0%, among which the most pronounced effect was with the use of a 0.3% solution (92.3% of cases). Compared with the control group adhesion score of 2.0 +/- 0. 8, significant decreases in adhesion scores were observed at all concentrations. HA with a molecular weight of 1.9x10(6) was recognized to have a definitive prevention effect on postoperative adhesions in mice after laparotomy and is considered to be a prospective material for future clinical use. (+info)Nitric oxide modulation of focal adhesions in endothelial cells. (6/635)
A permissive role of nitric oxide (NO) in endothelial cell migration and angiogenesis promoted by vascular endothelial growth factor (VEGF), endothelin, and substance P has previously been established. The present studies were designed to examine the mechanism(s) involved in the NO effect on focal adhesions. Time-lapse videomicroscopy of human umbilical vein endothelial cells (HUVECs) plated on the silicone rubber substrate revealed that unstimulated cells were constantly remodeling the wrinkling pattern, indicative of changing tractional forces. Application of NO donors reversibly decreased the degree of wrinkling, consistent with the release of tractional forces exerted by focal adhesions and stress fibers. Morphometric and immunocytochemical analyses showed that NO inhibited adhesion and spreading of HUVECs and attenuated recruitment of paxillin to focal adhesions. NO also had a profound dose-dependent effect on the formation of stress fibers by HUVECs. De novo formation of focal adhesions in HUVECs was significantly diminished in the presence of NO donors. Migration of HUVECs showed an absolute requirement for the functional NO synthase. NO donors did not interfere with focal adhesion kinase recruitment to focal adhesions but affected the state of its tyrosine phosphorylation, as judged from the results of immunoprecipitation and immunoblotting experiments. Videomicroscopy of HUVECs presented with VEGF in a micropipette showed that the rate of cell migration was slowed down by NO synthase inhibition as well as by inhibition of tyrosine phosphorylation. Collectively, these data indicate that NO reversibly releases tractional forces exerted by spreading endothelial cells via interference with the de novo formation of focal adhesions, tyrosine phosphorylation of components of focal adhesion complexes, and assembly of stress fibers. (+info)How long does laparoscopic surgery really take? Lessons learned from 1000 operative laparoscopies. (7/635)
The purpose of this study was to assess the operating time of the most common gynaecological laparoscopic procedures. We analysed retrospectively 1000 consecutive operative laparoscopies on a procedure-by-procedure basis. Diagnostic laparoscopy and laparoscopic sterilization were specifically excluded from the analysis. The various laparoscopic procedures were grouped and analysed under six major categories. The average operating time for all cases was 76.9 min (range 10-400). In 38 cases (3.8%) the laparoscopic procedure was converted to laparotomy. The average operating time for treating ectopic pregnancy and tubal disease was approximately 60 min (range 13-240). Surgery for endometriosis and ovarian cysts averaged 72 min (range 10-240). Laparoscopic myomectomy and hysterectomy averaged 113 and 131 min respectively (range 25-400). Our results show that while the operating time for most operative laparoscopies is less than 75 min, the range of operating times is great. The relative lack of predictability in procedure times means that the efficient utilization of fixed theatre sessions is difficult. (+info)The role of neutrophils in the formation of peritoneal adhesions. (8/635)
The most common cause of intraperitoneal adhesions which may result in infertility and intestinal obstruction is previous abdominal surgery. Surgical trauma of the peritoneum in the absence of infection elicits a rapid and transient influx of polymorphonuclear leukocytes (PMN) into the peritoneal cavity. The role of neutrophils in intraperitoneal adhesion formation has not been studied. We aimed to study the effects of PMN counts and PMN functions on peritoneal adhesion formation. Forty peritoneal adhesion-induced rats were randomly divided into three groups; group I, receiving saline; group II, receiving cyclophosphamide; and group III, receiving granulocyte-macrophage colony-stimulating factor (GM-CSF). In all groups, peritoneal lavage was performed to determine PMN counts the day after adhesion induction. Blood neutrophil counts and neutrophil functions were also determined. Adhesions were evaluated blindly 14 days after the operation. Adhesion tissue samples were microscopically evaluated. Tissue hydroxyproline and collagen concentrations were measured. The neutrophil counts and phagocytosis significantly increased in group III and neutrophil counts decreased in group II (P < 0.05). The score of adhesion formation in group II was significantly less than that in groups I and III (P < 0.05). Hydroxyproline concentrations of adhesion tissue were significantly decreased in group II when compared with group III (P < 0.05). The present study shows that neutropenia lowers the degree of postoperative adhesion formation. It is concluded that PMN may have a role to play in modulating post-operative adhesion formation. (+info)
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Adhesion (medicine)
They may be thought of as internal scar tissue that connects tissues not normally connected. Adhesions form as a natural part ... Abdominal adhesions (or intra-abdominal adhesions) are most commonly caused by abdominal surgical procedures. The adhesions ... The term "adhesion" is applied when the scar extends from within one tissue across to another, usually across a virtual space ... Filmy adhesions usually do not pose problems. Vascular adhesions are problematic. "adhesion" at Dorland's Medical Dictionary ...
William DeVries
Microbial adhesion vs tissue integration." ; Gristina A.G., Dobbins J.J., Giammara B., Lewis J.C., DeVries W.C. ; February 12, ... "Pulmonary tissue volume in isolated perfused dog lungs." ; Crapo R.O., Crapo J.D., Morris A.H., Berlin S.L., Devries W.C. ; May ...
Arabinogalactan protein
AGPs are found in a wide range of plant tissues, in secretions of cell culture medium of root, leaf, endosperm and embryo ... Huber, O.; Sumper, M. (1994-09-15). "Algal-CAMs: isoforms of a cell adhesion molecule in embryos of the alga Volvox with ... TTS: transmitting tissue specific. MTR: microspore and tapetum regulator. SOS: salt overly sensitive. XYP: xylogen protein. ... They have also been reported in secretions of cell culture medium of root, leaf, endosperm and embryo tissues, and some exudate ...
Carcinogenesis
You H, Lei P, Andreadis ST (December 2013). "JNK is a novel regulator of intercellular adhesion". Tissue Barriers. 1 (5): ... This correlation means that if normal stem cells from a tissue divide once, the cancer risk in that tissue is approximately 1X ... Cancer cells do not communicate with their tissue microenvironment in a manner that protects tissue integrity; instead, the ... between the risk of developing cancer in a tissue and the number of normal stem cell divisions taking place in that same tissue ...
Arginylglycylaspartic acid
Modifying vascular tissue grafts with RGD has been shown to inhibit platelet adhesion, improve cell infiltration and enhance ... The addition of RGD onto a cardiac tissue scaffold has been shown to promote cell adhesion, prevent apoptosis and enhance ... Tissue engineering aims to replace lost or damaged tissues within the body. The success of such efforts has depended greatly ... Huettner, Nick; Dargaville, Tim R.; Forget, Aurelien (2018-04-01). "Discovering Cell-Adhesion Peptides in Tissue Engineering: ...
Cell adhesion molecule
This antigen is known for its role in tissue-specific adhesion of lymphocytes to high endothelium venules. Through these ... Gumbiner, B. M. (1996-02-09). "Cell adhesion: the molecular basis of tissue architecture and morphogenesis". Cell. 84 (3): 345- ... Cell adhesion molecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells ... "Single-pass transmembrane adhesion and structural proteins". membranome. College of Pharmacy, University of Michigan. Retrieved ...
Cell adhesion
Other cellular processes regulated by cell adhesion include cell migration and tissue development in multicellular organisms. ... Anti-adhesion therapy can be used to prevent infection by targeting adhesion molecules either on the pathogen or on the host ... Gumbiner, Barry M. (1996). "Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis". Cell. 84 (3): 345-357 ... Dysfunction of cell adhesion occurs during cancer metastasis. Loss of cell-cell adhesion in metastatic tumour cells allows them ...
JAM2
2004). "Junctional adhesion molecules and interendothelial junctions". Cells Tissues Organs (Print). 172 (3): 152-60. doi: ... Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene. JAM2 has also been designated as CD322 ... 2004). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a ... "Entrez Gene: JAM2 junctional adhesion molecule 2". Johnson-Léger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA ( ...
Outline of cell biology
Cell adhesion - Holding together cells and tissues. Motility and Cell migration - The various means for a cell to move, guided ... Tissues - A collection of interconnected cells that perform a similar function within an organism. Cellular differentiation - A ... Cell therapy - The process of introducing new cells into a tissue in order to treat a disease. Cloning - Processes used to ... which is the process that gives rise to tissues, organs and anatomy. Microbiology - The study of microorganisms, which are ...
Cadherin-2
... is a transmembrane protein expressed in multiple tissues and functions to mediate cell-cell adhesion. In cardiac ... Cadherin-2, originally named Neural cadherin for its role in neural tissue, plays a role in neurons and later was found to also ... Doherty P, Smith P, Walsh FS (1997). "Shared cell adhesion molecule (CAM) homology domains point to CAMs signalling via FGF ... In neural cells, at certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part ...
Differential adhesion hypothesis
... where tissues with weaker surface adhesion surround tissues with stronger surface adhesion, the rounding of irregular cell ... In DAH tissues are treated as liquids consisting of mobile cells whose varying degrees of surface adhesion cause them to ... Duguay, Duke; Foty, Ramsey A.; Steinberg, Malcolm S. (15 January 2003). "Cadherin-mediated cell adhesion and tissue segregation ... This allows examples of tissue arrangement to be corresponded to the behavior of liquids, such as one tissue spreading across ...
Paratenonitis
Peritendinous tissues become macroscopically thickened and new connective tissue adhesions occur. In paratenonitis, ... Soft tissue, Skeletal system, Tendons, All stub articles, Musculoskeletal disease stubs). ...
Oesophagostomum
... these adhesions were filled with fat, enlarged glands and omental tissue. Underneath were a multitude of small cystic tumors ... The larvae usually found in tissues can be 500 nanometers or longer in length. With microscopy, one can identify the larvae ... Examination of the exterior of the ascending colon revealed the formation of thick adhesions spanning the whole length of the ... The developing worms then penetrate the intestinal tissues, causing nodular lesion formation in the intestines and colon; it is ...
Laparoscopy
Adhesions are fibrous deposits that connect tissue to organ post surgery. Generally, they occur in 50-100% of all abdominal ... Coagulation disorders and dense adhesions (scar tissue) from previous abdominal surgery may pose added risk for laparoscopic ... This results in an inability to accurately judge how much force is applied to tissue and higher risk of damaging tissue by ... CO2 is used because it is common to the human body and can be absorbed by tissue and removed by the respiratory system. It is ...
M. Lisa Manning
"Coaction of intercellular adhesion and cortical tension specifies tissue surface tension". Proceedings of the National Academy ... Manning has developed a model describing the relationship between cell adhesion and cortical tension as a determinant for ... Her ongoing research modeling the relationship between cell shape and jamming leading to tissue rigidity has implications for ... Merkel, Matthias; Manning, Lisa; Schwarz, J. M; Manning, M. Lisa (2013). "Energy barriers govern glassy dynamics in tissues". ...
Diaphragmatic rupture
This is done be debriding nonviable tissue and closing the rupture. Most of the time, the injury is repaired during laparotomy ... Early surgery is important, as diaphragmatic atrophy and adhesions occur over time. Sutures are used in the repair. Other ...
Shoulder problem
Adhesions (abnormal bands of tissue) grow between the joint surfaces, restricting motion. There is also a lack of synovial ... The capsule is a soft tissue envelope that encircles the glenohumeral joint. It is lined by a thin, smooth synovial membrane.[ ... Tendons are tough cords of tissue that attach the shoulder muscles to bone and assist the muscles in moving the shoulder. ... This instability increases the likelihood of joint injury, often leading to a degenerative process in which tissues break down ...
Xenopus
Dzamba BJ, Jakab KR, Marsden M, Schwartz MA, DeSimone DW (March 2009). "Cadherin adhesion, tissue tension, and noncanonical Wnt ... In a vastly different study, Xenopus embryos was used to study the effects of tissue tension on morphogenesis, an issue that ... the Xenopus epidermis have recently been developed as the first in vivo test-bed for live-cell studies of such ciliated tissues ... will be critical for in vitro tissue engineering. Xenopus species are important model organisms for the study of spinal cord ...
Adhesive capsulitis of the shoulder
This is the result of scar tissue (adhesions) around the joint capsule. There also may be a reduction in synovial fluid, which ... Under the microscope, the appearance of the affected shoulder joint capsule tissue is similar to the appearance of the tissue ... Surgery to cut the adhesions (capsular release) may be indicated in prolonged and severe cases; the procedure is usually ... Manipulation of the shoulder under general anesthesia to break up the adhesions is sometimes used. Hydrodilatation or ...
Tube-based nanostructure
The cross-linked tubes are more suitable structures for cell adhesion and spreading. Potential applications include tissue ... Such materials are of particular interest for tissue engineering since they allow the precise control of physical and ...
Adjustable gastric band
However, it is not entirely reversible as adhesions and tissue scarring are inevitable. Unlike those who have procedures such ... Despite these difficulties, silicone was identified as the best-tolerated material, with far fewer adhesions and tissue ... Other complications include: Ulceration Gastritis (irritated stomach tissue) Erosion - The band may slowly migrate through the ... this type of fill is not possible because of issues such as partial rotation of the port or excess tissue above the port ...
Hemothorax
The retained blood can irritate the pleura, causing scar tissue (adhesions) to form. If extensive, this scar tissue can encase ... Endometriotic tissue that implants on the pleural surface can bleed in response to the hormonal changes of the menstrual cycle ... The lungs are surrounded by two layers of tissue called the pulmonary pleurae. In most healthy people, these two layers are ... Rarely, hemothoraces can arise due to extrapelvic endometriosis, a condition in which tissue similar to the lining that ...
Stress fiber
Gumbiner, Barry M (February 1996). "Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis". Cell. 84 (3 ... Focal adhesions are usually connected to stress fibers-in fact, stress fiber contractility is necessary for focal adhesion ... In the actin cytoskeleton, mechanotransduction can occur at cell-ECM and cell-cell adhesions, through focal adhesions and ... and function in adhesion and contraction. Transverse arcs are not directly linked to focal adhesions, and typically flow from ...
Tissue transglutaminase
Akimov SS, Krylov D, Fleischman LF, Belkin AM (February 2000). "Tissue transglutaminase is an integrin-binding adhesion ... Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC 2.3.2.13) of the protein- ... Hasegawa G, Suwa M, Ichikawa Y, Ohtsuka T, Kumagai S, Kikuchi M, Sato Y, Saito Y (August 2003). "A novel function of tissue- ... Wilhelmus MM, Verhaar R, Andringa G, Bol JG, Cras P, Shan L, Hoozemans JJ, Drukarch B (March 2011). "Presence of tissue ...
Implantation (embryology)
IVF-infertility.com Singh H, Aplin JD (July 2009). "Adhesion molecules in endometrial epithelium: tissue integrity and embryo ... Cadherins are cell adhesion molecules, and beta-catenin helps to anchor them to the cell membrane. Inhibited expression of ... Adhesion is a much stronger attachment to the endometrium than the loose apposition. The trophoblasts adhere by penetrating the ... Cell adhesion molecules are degraded by syncytiotrophoblast secretion of tumor necrosis factor-alpha. This inhibits the ...
Mooren's ulcer
Upregulation of adhesion molecules allows leukocyte migration into inflamed tissues. Co-stimulatory molecules may contribute to ... Also, significantly increased expression levels of adhesion and co-stimulatory molecules have been found in ocular tissues ... Amniotic membrane patches are prepared from placental tissues from women who had a planned cesarean sections. AMT appears to be ... mediators and enzymes which cause the tissue damage. Another surgical treatment option which has been successfully used as a ...
Cadherin
Duguay D, Foty RA, Steinberg MS (January 2003). "Cadherin-mediated cell adhesion and tissue segregation: qualitative and ... Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the ... N-cadherins have different functions that maintain the cell structure, cell-cell adhesion, internal adhesions. They participate ... Cell-cell adhesion is mediated by extracellular cadherin domains, whereas the intracellular cytoplasmic tail associates with ...
CDH3 (gene)
"Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas". Cancer Research. 49 (8): 2128-33. PMID 2702654. ... Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Oct 1992). "The gene for the cell adhesion molecule ... Rufas O, Fisch B, Ziv S, Shalgi R (Feb 2000). "Expression of cadherin adhesion molecules on human gametes". Molecular Human ... The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a ...
Hyalobarrier
... is a substance to keep tissue apart post surgery and therefore prevent adhesions. It contains autocross-linked ... Sutton C (2009). "Adhesions following surgery: pathogenesis and current experience with adhesion barriers". Surg Technol Int. ... The Cochrane report also states that the incidence of postsurgical adhesions is as high as 50 to 100%. In a recent review by C ... According to data in a Cochrane collaboration review barrier agents may be a little more effective in preventing adhesions than ...
Clitoral hood
Sticky bands of tissue called adhesions can form between the hood and the glans; these stick the hood onto the glans so the ... The clitoral hood is composed of muccocutaneous tissues; these tissues are between the mucous membrane and the skin, and they ... The clitoral hood is formed from the same tissues that form the foreskin in human males. The clitoral hood varies in the size, ... The clitoral hood is also important not only in the protection of the clitoral glans, but also in pleasure, as its tissue forms ...
Proto-oncogene tyrosine-protein kinase Src
Elevated expression levels of c-Src were found in human breast cancer tissues compared to normal tissues. Overexpression of ... c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein ... The expression of these Src family members are not the same throughout all tissues and cell types. Src, Fyn and Yes are ... Oberg-Welsh C, Welsh M (January 1995). "Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution ...
TENM3
Teneurins are homophilic adhesion molecules that bind specifically to other teneurin-family molecules on adjacent cells. The ... They are also expressed in some non-neuronal tissues that regulate pattern formation and sites of cell migration. Some Ten-m3 ... This interaction facilitates neurite outgrowth and the adhesion strength needed to stop outgrowth. The dimerisation of the ... areas of the developing nervous system and in some non-neural tissues. Like the Ten-m family, Ten-m3 plays a critical role in ...
Papillary tumors of the pineal region
The cells of the tumor will often grow into nearby normal brain tissue. Grade III tumors tend to recur as higher-grade tumors. ... neural cell adhesion molecule) → ++ S100 → ++ Transthyretin → - Vimentin → +++ Desmin → - SMA (smooth muscle actin) → + The ... They have a slightly abnormal microscopic appearance and can spread into nearby normal tissue. Grade II tumors can also recur ...
Metabolism
Other than fat, glucose is stored in most tissues, as an energy resource available within the tissue through glycogenesis which ... Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell ... A parallel approach is to identify the small molecules in a cell or tissue; the complete set of these molecules is called the ... Ions are also critical for nerve and muscle function, as action potentials in these tissues are produced by the exchange of ...
Catenin
Mice lacking plakoglobin have cell adhesion defects in many tissues, although β-catenin substitutes for plakoglobin at many ... providing the cell with a means of stable cell adhesion. However, decreases in this adhesion ability of the cell has been ... some treatment concepts involve upregulating the E-cadherin/catenin adhesion system to prevent disruptions in adhesions and ... A tumor cell line with defective δ-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be restored to normal ...
Follicular dendritic cells
Adhesion between FDCs and B cells is mediated by ICAM-1 (CD54)-LFA-1 (CD11a) and VCAM-VLA-4 molecules. Activated B-cells with ... In normal lymphoid tissue, recirculating resting B cells migrate through the FDC networks, whereas antigen-activated B cells ... These sarcomas often involve lymphoid tissues, but in a number of cases the tumor has been found in the liver, bile duct, ... Factor Mfge produced in lymphoid tissues mainly by FDCs is known to enhance engulfment of apoptotic cells. Deficit of this ...
Rocky Mountain spotted fever
Studies have suggested that rOmpB is involved in this process of adhesion and invasion. Both rOmpA and rOmpB are members of a ... However, in some cases a Rickettsia rickettsii infection has been contracted by contact with tick tissues or fluids. Then, the ... Less commonly, infections may occur following exposure to crushed tick tissues, fluids, or tick feces. A female tick can ... resulting in mononuclear cell infiltration into blood vessels and subsequent red blood cell leakage into surrounding tissues. ...
Ureterovaginal fistula
Difficult deliveries can create pressure necrosis in the tissue that is being pushed between the head of the infant and the ... with the repair of the fistula are also associated with most other surgical procedures and include the risk of adhesions, ... softer tissues of the vagina, ureters, and bladder. Radiographic imaging can assist clinicians in identifying the abnormality. ... can be troubling for women especially since some clinicians delay treatment until inflammation is reduced and stronger tissue ...
Fibroblast-like synoviocyte
FLS that are present in the synovium during RA display altered phenotype compared to the cells present in normal tissues. They ... Furthermore these cells express a number of molecules important for the mediation of the cell adhesion, such as cadherin-11, ... both these phenomena contribute to the increase in the number of FLS in the inflammatory tissue and are also typical for ...
CD34
... is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node ... The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes ... Drew E, Merzaban JS, Seo W, Ziltener HJ, McNagny KM (January 2005). "CD34 and CD43 inhibit mast cell adhesion and are required ... as a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of ...
FAM178B
... is most highly expressed in the skeletal muscle and brain tissues.The structure in which it is highly concentrated is ... and cell adhesion. A proposed structure for the protein can be found in the images for proposed structures. The secondary ...
Mineral (nutrient)
Loskill P, Zeitz C, Grandthyll S, Thewes N, Müller F, Bischoff M, Herrmann M, Jacobs K (May 2013). "Reduced adhesion of oral ... Currey, JD (1999). "The design of mineralised hard tissues for their mechanical functions". The Journal of Experimental Biology ... Journal of Hard Tissue Biology. 21 (3): 475-6. doi:10.2485/jhtb.21.257. Retrieved 2017-06-01. ... "Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture". Cell. 157 ...
Fitz-Hugh-Curtis syndrome
Occasionally, this inflammation can cause scar tissue to form on Glisson's capsule, a thin layer of connective tissue ... Laparoscopy for lysis of adhesions may be performed for refractory pain.[citation needed] Peter, N. G.; Clark, L. R.; Jaeger, J ... Curtis, Arthur H. (1930). "A cause of adhesions in the right upper quadrant". JAMA. 94 (16): 1221-2. doi:10.1001/jama. ... adhesions of parietal peritoneum to liver.[citation needed] Treatment involves a course of antibiotics to cover the appropriate ...
Oral candidiasis
This adhesion involves adhesins (e.g., hyphal wall protein 1), and extracellular polymeric materials (e.g., mannoprotein). ... This candidal carriage state is not considered a disease, but when Candida species become pathogenic and invade host tissues, ... When Candida species cause lesions - the result of invasion of the host tissues - this is termed candidiasis. Some consider ... In vitro and studies show that Candidal growth, adhesion and biofilm formation is enhanced by the presence of carbohydrates ...
Morula
1997). "Morphogenesis of epithelial cells". In Paul, Leendert C.; Issekutz, Thomas B. (eds.). Adhesion molecules in health and ... while the trophectoderm will form the placenta and extra-embryonic tissues. However, reptiles have a different ICM. The stages ...
Anthony Mahowald
Mahowald discovered that this area, and specifically the e-cadherin-based stem cell adhesion, is vital in maintaining the ... Despite all of this, Mahowald concluded that tissues rich in Act5C gene expression cannot adequately function with only the ... Srinivasan S, Mahowald AP, Fuller MT (April 2012). "The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila ... and tissue-specific manner". Cell. 33 (1): 115-23. doi:10.1016/0092-8674(83)90340-9. PMID 6432334. S2CID 23746956. Herman IM ( ...
Michael A. Sutton
The adhesion of uncured, unidirectional composite tows that are adhered to a similar composite tow using automated fiber ... Lessner had a long-term interest in measuring the response of soft biological tissues, such as arteries, when subjected to ... Of particular interest was the work performed with Ying Wang regarding the separation resistance of arterial tissues that ... energy release rate was an excellent parameter to characterize the separation resistance of dissections in arterial tissues. ...
Biometal (biology)
In animals, iron plays a very important role in transporting oxygen from the lungs to tissues and CO2 from tissues to the lungs ... The calcium bound proteins usually play an important role in cell-cell adhesion, hydrolytic processes (such as hydrolytic ... In humans, zinc is primarily found in various organs and tissues such as the brain, intestines, pancreas and mammary glands. In ... Hemoglobin in the blood transports oxygen from the lungs to myoglobin in tissues. Both proteins are tetramer complexes with ...
CD151
It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This ... in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin". J. Histochem. Cytochem. 45 (4): 515-25. doi: ... "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase". Int. J. Cancer. 97 (3): ...
Antimicrobial
Designing effective antimicrobial surfaces demands an in-depth understanding of the initial microbe-surface adhesion mechanisms ... which are applied to living tissue and help reduce infection during surgery), and antibiotics (which destroy microorganisms ...
SPTAN1
In cardiac tissue, alpha II-spectrin is found in myocytes at Z-discs, costameres, and the sarcolemma membrane, and in cardiac ... Metral S, Machnicka B, Bigot S, Colin Y, Dhermy D, Lecomte MC (Jan 2009). "AlphaII-spectrin is critical for cell adhesion and ... Alpha II-spectrin is expressed in a variety of tissues, and is highly expressed in cardiac muscle at Z-disc structures, ... As opposed to alpha I-spectrin that is principally found in erythrocytes, alpha II-spectrin is expressed in most tissues. ...
Lichen planus
Tissue biopsies of oral LP help to confirm the diagnosis and are particularly of value for erythematous and erosive LP, which ... Upregulation of intercellular adhesion molecule-1 (ICAM-1) and cytokines associated with T-helper 1 immune response, may also ... as is characteristics of oral LP Viral infection Oral LP is considered to be a T-cell mediated chronic inflammatory tissue ...
Waldenström macroglobulinemia
Source: Modified from WHO Blue Book on Tumour of Hematopoietic and Lymphoid Tissues. 2001, p. 2001.) Waldenstrom J (1944). " ... "Src tyrosine kinase regulates adhesion and chemotaxis in Waldenstrom macroglobulinemia". Clinical Cancer Research. 15 (19): ... The LDH level is frequently elevated, indicating the extent of Waldenström macroglobulinemia-related tissue involvement. ... "The World Health Organization classification of neoplastic diseases of the haematopoietic and lymphoid tissues: Report of the ...
Alpha-1 antitrypsin
... which breaks down the connective tissue fiber elastin. Besides limiting elastase activity to limit tissue degradation, A1PI ... adhesion molecules, cytokines, and stromal cells". Exp Hematol. 30 (9): 973-981. doi:10.1016/s0301-472x(02)00883-4. PMID ... Besides liver cells, A1PI is produced in bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth ... This suggests a role for α1PI not only in locomotion of lymphocytes through tissue, but as a consequence of infection, a ...
Biofilling
B. Apical 1/3 The apical portion of the root canal can never be dried because of the tissue fluid. The commonly used AH26 and ... 1. No sealability (no adhesion to dentine) It was concluded that gutta percha's drawback is the lack of seal. Failure of root ... Formation of the apical plug can prevent the apical percolation of nutrient tissue fluid. In addition, an apical plug can make ... 3. Biological Sealing - During Biofilling, a Bioceramic material is used which is nonirritating to periapical tissues and also ...
Microtubule
"Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase". Nature Cell Biology. 7 (6): ... The originally identified MAPs from brain tissue can be classified into two groups based on their molecular weight. This first ... Ren XD, Kiosses WB, Schwartz MA (February 1999). "Regulation of the small GTP-binding protein Rho by cell adhesion and the ... Ott C, Iwanciw D, Graness A, Giehl K, Goppelt-Struebe M (November 2003). "Modulation of the expression of connective tissue ...
Appendicitis
... reduced blood flow to the appendix and distention of the appendix causes tissue injury and tissue death. If this process is ... bleeding and adhesions. Evidence indicates that a delay in obtaining surgery after admission results in no measurable ... the surgeon removes the infected tissue and cuts the appendix from the surrounding tissue. After careful and close inspection ... Inflamed lymphoid tissue from a viral infection, parasites, gallstone, or tumors may also cause the blockage. This blockage ...
Desmosome
... s are one of the stronger cell-to-cell adhesion types and are found in tissue that experience intense mechanical ... is a cell structure specialized for cell-to-cell adhesion. A type of junctional complex, they are localized spot-like adhesions ... Both disease result in a loss of keratinocyte adhesion. Pemphigus can also be caused by a bacterial infection: bullous impetigo ... Extracellular calcium helps form the cadherin adhesion by allowing the cadherin extracellular domain on desmoglein and ...
Scar Tissue Treatment/Adhesions/Contractures Archives - Astym
This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience ...
US6283916B1 - Expert system soft tissue active motion technique for release of adhesions and associated apparatus for...
... point near the lesion and causing the patient to move in a manner that produces a longitudinal sliding motion of soft tissues, ... A method for the non-surgical treatment of soft tissue lesions includes placing a contact ... A key principle of the invention is that soft tissue adhesions can be treated by longitudinal manipulation of soft tissues in ... Tissues that are adjacent to these weak and tense tissues may also be drawn tight. Weak and tense tissues produce corresponding ...
The Penetration of Anticancer Drugs through Tumor Tissue as a Function of Cellular Adhesion and Packing Density of Tumor Cells ...
The Penetration of Anticancer Drugs through Tumor Tissue as a Function of Cellular Adhesion and Packing Density of Tumor Cells ... The Penetration of Anticancer Drugs through Tumor Tissue as a Function of Cellular Adhesion and Packing Density of Tumor Cells ... 1A). A cell-free tissue culture insert was included in all experiments as a control. Experiments were conducted at 37°C in ... The goals of the present study were to quantify the penetration of anticancer drugs as a function of cellular adhesion and ...
Modulation of cell-cell interactions for neural tissue engineering : potential therapeutic applications of cell adhesion...
Modulation of cell-cell interactions for neural tissue engineering : potential therapeutic applications of cell adhesion ... Neural tissue engineering holds great promise in repairing damaged nerve tissues. However, despite the promising results in ... Therefore, modulating cell-cell interactions through cell adhesion molecules (CAMs) such as cadherins, neural cell adhesion ... As another important component in nerve tissues, the potential of modulating cell-cell interactions as a strategy to promote ...
Figure 3 | Hydration-Enhanced Lubricating Electrospun Nanofibrous Membranes Prevent Tissue Adhesion
Scar Tissue and Adhesions | Trauma Recovery Clinic
Scar Tissue and Adhesions and their effects on the body. Scar Tissue and Adhesions are the bodys own mechanism for healing ... Causes of scar tissue and adhesions. • Surgery - after any type of surgery, even keyhole surgery, there will be scar tissue or ... Valleys, ravines or ridges where scar tissue is hardened. The release of Scar Tissue or Adhesions can prove to be the ... Cosmetic treatment of Scar Tissue. We do not do scar tissue release primarily for cosmetic purposes, however scar tissue ...
A novel RGD-independent cell adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikis ...
A novel RGD-independent cell adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikis ... A novel RGD-independent cell adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikis ... RGD-independent cell adhesion to tTG-FN does not require transamidating activity, is mediated by the binding of tTG to cell- ... Specific association of tissue transglutaminase (tTG) with matrix fibronectin results in the formation of an extracellular ...
Adhesions | Abdominal Adhesions | MedlinePlus
Learn about the signs, symptoms, and causes this type of scar tissue. ... Abdominal surgery is the main cause of adhesions but not the only one. ... ClinicalTrials.gov: Adhesions (National Institutes of Health) * ClinicalTrials.gov: Tissue Adhesions (National Institutes of ... Adhesions are bands of scar-like tissue. Normally, internal tissues and organs have slippery surfaces so they can shift easily ...
Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins? | Center for Bioengineering & Tissue...
Cell Adhesion, Eukaryotic Cells, Matrix Metalloproteinases, Tumor Suppressor Proteins. Abstract. Matrix metalloproteinases are ... Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins?. Mar 28, 2014. *BibTeX ... RECK, a membrane-anchored inhibitor of MMPs was recently characterized for its role in development, tissue homeostasis, and for ... enzymes that regulate tissue behavior by interactions with extracellular matrix proteins. ...
IJMS | Free Full-Text | The Janus Role of Adhesion in Chondrogenesis
... substrate adhesion in the tissue engineering strategies for cartilage repair. ... During chondrogenesis, the extracellular matrix continuously evolves, adapting to the tissue adhesive requirements at each ... The influence of adhesive crosstalk between cell-cell adhesions and cell-ECM adhesions has been previously described in early ... Anisotropic nanoscale presentation of cell adhesion ligand enhances the recruitment of diverse integrins in adhesion structures ...
PDF] Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes | Semantic Scholar
Mechanical forces acting on cell adhesion receptor proteins regulate a range of cellular functions by formation and rupture of ... Significance Selectins and integrins are receptor proteins on cell surfaces responsible for adhesion to extracellular ... Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis. *B. Gumbiner ... Bacterial Adhesion to Target Cells Enhanced by Shear Force. *W. Thomas, E. Trintchina, M. Forero, V. Vogel, E. Sokurenko ...
Leukocyte Adhesion Deficiency Follow-up: Further Outpatient Care, Further Inpatient Care, Inpatient & Outpatient Medications
Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency. The clinical picture is characterized by marked ... Wild MK, Luhn K, Marquardt T, Vestweber D. Leukocyte adhesion deficiency II: therapy and genetic defect. Cells Tissues Organs. ... Cell adhesion and leukocyte adhesion defects. Ochs HD, Puck JM, Smith CI, eds. Primary Immunodeficiency Diseases: A Molecular ... Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands. Curr ...
SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion
Nerve Tissue Proteins / metabolism* * Nonmuscle Myosin Type IIA / metabolism* * Podocytes / cytology* * Receptors, Immunologic ... SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion JCI Insight. ... In addition, SLIT2 stimulation inhibits NMIIA activity, decreases focal adhesion formation, and reduces podocyte attachment to ... regulates podocyte adhesion downstream of ROBO2. We found that the myosin II regulatory light chain (MRLC), a subunit of NMIIA ...
Locking Plates - Minimizing soft tissue irritation and adhesions, Stable anatomic reduction with angled locking technology
Scar Tissue, Fibrosis, and Fascial Adhesions are a Large and Often Overlooked Cause of Treatable Chronic Pain
... as well as one of the chief problems that occurs within this tissue - FASCIAL ADHESIONS / SCAR TISSUE / FIBROSIS. My answer? I ... FASCIA ADHESION, FIBROSIS & SCAR TISSUE. WHY SO MUCH INFORMATION ON MY WEBSITE?. ... Tissue injury also causes the release of numerous chemicals at the site of damage and inflammation. Prostaglandins enhance the ... In plain English, this means that Scar Tissue / Fibrosis has the potential to be chronic pains "PERFECT STORM". How so? ...
Cell Adhesion and Mechanics | Active nematics across scales from cytoskeleton organization to tissue morphogenesis
Biological tissues are composed of various cell types working cooperatively to perform their respective function within organs ... These cells are anchored to each other and/or the underlying substrate through adhesion complexes and they regulate force ... The resulting contractility related changes at the level of each single cell impact tissue architecture by triggering changes ...
References | BSI | Guidelines Library | Infection Control | CDC
The α-Catenin mechanosensing M region is required for cell adhesion during tissue morphogenesis. | J Cell Biol;222(2)2023...
The α-Catenin mechanosensing M region is required for cell adhesion during tissue morphogenesis. ... The α-Catenin mechanosensing M region is required for cell adhesion during tissue mor ... Individual M region domains make complex contributions to cell adhesion through their impact on interaction partner recruitment ... Catenin mechanosensing in support of cell adhesion. Low-, medium-, and high-tension contacts showed a corresponding recruitment ...
Massage and Orthopedic Pathologies | Massage Therapy Journal
Soft tissue rehabilitation is a mainstay of massage therapy in orthopedic settings. ... "Thats when scar tissue is forming, but not yet unmoldable," he says. "Techniques begin with helping the client regain mobility ... Perhaps the best-known shoulder problem is frozen shoulder, medically known as adhesive capsulitis, which involves adhesions ... Massage therapists have an opportunity to really slow down and spend time with the client to feel whats going on in the tissue ...
Penile Adhesion: Skin Bridge, in Adults, Uncircumcised
A penile adhesion develops when the skin of the penis shaft adheres or sticks to the skin of the penis head, also known as the ... This contraction of scar tissue is called a cicatrix.. You may be advised to apply a topical steroid cream to the area to help ... Penile adhesions. (n.d.).. chop.edu/conditions-diseases/penile-adhesions. *. Penile adhesions and skin bridges. (2016).. my. ... Glanular adhesions. A glanular adhesion is less serious than a skin bridge. It can also involve a connection between the shaft ...
Labial Adhesions: Practice Essentials, Background, Pathophysiology and Etiology
Labial adhesions (also referred to as labial agglutination) are a common disorder in prepubertal females. This disorder is ... Labial adhesions may also be caused by vaginal inflammation, local irritation, or tissue trauma. They have been reported to ... Labial adhesions are fibrous adhesions between the labia majora. Low estrogen levels have been thought to play a causative role ... 5] Labial adhesions have not been reported in the newborn period. If left untreated, labial adhesions usually spontaneously ...
2023 ICD-10-CM Diagnosis Code M26.612: Adhesions and ankylosis of left temporomandibular joint
ICD 10 code for Adhesions and ankylosis of left temporomandibular joint. Get free rules, notes, crosswalks, synonyms, history ... Diseases of the musculoskeletal system and connective tissue. Note*Use an external cause code following the code for the ... M26.611 Adhesions and ankylosis of right temporomandibular joint M26.612 Adhesions and ankylosis of left temporomandibular ... Adhesions and ankylosis of left temporomandibular joint. 2017 - New Code 2018 2019 2020 2021 2022 2023 Billable/Specific Code * ...
Biofilms: Microbial Life on Surfaces - Volume 8, Number 9-September 2002 - Emerging Infectious Diseases journal - CDC
Bacterial adhesion to cells and tissues. In: Ofek I, Doyle RJ, editors. New York: Chapman & Hall; 1994. ... Adhesion to biomaterials. In: Fletcher M, editor. Bacterial adhesion: molecular and ecological diversity. New York: Wiley-Liss ... On bacterial adhesion - the effect of certain enzymes on adhered cells in a marine Pseudomonas sp. Bot Mar. 1977;20:13-7. DOI ... Bacterial adhesion under static and dynamic conditions. Appl Environ Microbiol. 1993;59:3255-65.PubMedGoogle Scholar ...
MAUDE Adverse Event Report: TISSUE SCIENCE LABORATORIES MESH TSL - PERMACOL¿ MESH, SURGICAL
Patient Problems Corneal Pannus (1447); Abscess (1690); Adhesion(s) (1695); Bacterial Infection (1735); Cellulitis (1768); ... TISSUE SCIENCE LABORATORIES MESH TSL - PERMACOL¿ MESH, SURGICAL Back to Search Results. ... MAUDE Adverse Event Report: TISSUE SCIENCE LABORATORIES MESH TSL - PERMACOL¿ MESH, SURGICAL. *. ...
A Novel Model of Surgical Injury in Adult Rat Kidney: A "Pouch Model" | Scientific Reports
... prevented formation of adhesions and induced characteristic wound healing manifested by formation of granulation tissue. ... Additionally, selected tubules of the wounded kidney extended into the granulation tissue forming branching tubular epithelial ... In rodent models, extrarenal tissues adhere to surgical kidney wound and interfere with healing. We hypothesized that this can ... 1A-D), adhesions of the extrarenal tissues were effectively prevented (Fig. 1D, F & G). A distinct granulation tissue layer - ...
Scars | Health Library | Alton Memorial Hospital
Tissue expansion. This is a newer method. It uses a process that increases the amount of existing tissue available for ... Adhesions. This is another type of scarring that may form between unconnected internal organs. Adhesions may cause problems ... Skin grafts or skin flaps are done after the scar tissue is removed. For a skin graft, skin is replaced or attached to a part ... These are thick, rounded, irregular groups of scar tissue. They grow at the site of a skin wound. But they can be much larger ...
C-Section Complications | American Pregnancy Association
The Immune Response to Mycobacterium tuberculosis Infection in Humans | IntechOpen
TNFα activates adhesion molecules on the immunocytes [48]. Thus the granuloma is a dynamic and continuous battlefield balancing ... This enables the bacteria to proliferate with enhancement of tissue damaging inflammation, which may result in cavity formation ... The granuloma contains a nucleus of necrotic lung tissue and intraphagosomal bacteria-containing macrophages, surrounded by ... thereby enabling them to form a permanent infection and damaging pulmonary tissue [45]. More specifically, the bacteria possess ...
ZEISS Receives FDA Clearance for MTLawton | Carl Zeiss Meditec AG
The surgical instrument reduces tissue adhesion and allows a clear view of the coagulation for efficient preparation. ... These new disposable bipolar forceps are made from a special copper-base alloy and potentially reduce tissue adhesion and ... The surgical instrument reduces tissue adhesion and allows a clear view of the coagulation for efficient preparation. ... Our copper-base alloy has superior thermal conduction to improve cautery-based hemostasis and reduce tissue adhesion," ...
Patients with leukocyte adhesion defiInflammationLeukocyte adhesion deficiencRemoval of adhesionsRelease of adhesionsBowelSurgeryOrgansFocal adhesiAbdominalAnatomicExtracellular matrixMesenchymal stemSurfacesMucosal tissuesIntestineUterusSoft tissuePelvisDeep tissueCellularCellEndothelial cellsBlood vesselsSURGICALDifferentiationReduceTumorFibrousDense irreguFasciaFallopianBlockageBacterialBenignReducesFormationRegenerationInvolveConnective tissue dWoundMediateResectionBody'sProteinEndometriosisInjuryBiomaterialsLigamentsMoleculesDefectPainfulInfectionBehaviorPainAbdomen
Patients with leukocyte adhesion defi4
- Patients with leukocyte adhesion deficiency II experience growth failure and mental retardation, although they are less likely to die of infection. (medscape.com)
- Patients with leukocyte adhesion deficiency II show severe developmental delay, which has not been significantly prevented even when fucose replacement seemed to decrease infections and improve phagocytic functions. (medscape.com)
- Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
- However, IgM and IgG serum levels are within the reference range in patients with leukocyte adhesion deficiency II. (medscape.com)
Inflammation8
- Scar tissue is most often caused by surgery or injury, but can also come about after inflammation, where the tissue has had to scar over to heal. (traumarecoveryclinic.com)
- Significance Selectins and integrins are receptor proteins on cell surfaces responsible for adhesion to extracellular biomolecules, a critical component of physiological processes like white blood cell localization at sites of inflammation. (semanticscholar.org)
- Surgery, inflammation, or injury can cause tissues to bond to other tissue or organs, similar to the forming of scar tissue. (pituitary.org)
- The main reason for her decision was the prognosis of less inflammation of the peri-implant tissue with ceramic implants. (nobelbiocare.com)
- Once injured, the immune system jumps in to repair things, which leads to inflammation and the production of scar tissue called a fibrin matrix. (fallopiantubeformula.com)
- Similar signals regulate the transition from inflammation to ectopic or tertiary lymphoid tissues. (aai.org)
- Adhesions in the muscle are very important to address because they cause pain, inflammation and limit motion of the muscles and joints. (cntmassagetherapy.com)
- If you have recently had surgery, MLD is highly recommended to help reduce inflammation, increase range of motion, speed healing and reduce bruising, and reduce scar tissue. (bodybalancemassagetherapy.com)
Leukocyte adhesion deficienc1
- Cagdas D, Yilmaz M, Kandemir N, Tezcan I, Etzioni A, Sanal O. A Novel Mutation in Leukocyte Adhesion Deficiency Type II/CDGIIc. (medscape.com)
Removal of adhesions2
- Studies suggest that surgical removal of adhesions reduces pain and increases fertility as well as spontaneous conception. (talosintuitivecare.com)
- In case this kind of surgery is needed, removal of adhesions will free bowel loops from connecting to the abdominal cavity or other adjusting organs and fallopian tubes from being stuck to the pelvic sidewalls. (talosintuitivecare.com)
Release of adhesions1
- A key step in cell migration is the dynamic formation and disassembly of adhesions at the front and the concomitant movement and release of adhesions in the rear of the cell. (biologists.com)
Bowel5
- Structural disorders, such as intraluminal and extraluminal bowel lesions caused by primary or metastatic tumor, postoperative adhesions, volvulus of the bowel, or incarcerated hernia, affect peristalsis and the maintenance of normal bowel function. (nih.gov)
- When adhesions are formed the structures become fixed to parts of the abdomen causing problems (i.e., pain, complications from the bowel, infertility, etc. (talosintuitivecare.com)
- Bowel endometriosis can also result in adhesions (scar tissue). (endosupp.com)
- These adhesions can involve other loops of bowel resulting in a partial obstruction (blockage), the ovary, fallopian tube or even the ureter. (endosupp.com)
- We carried out laparotomy and thoracotomy that achieved lysis of adhesions, reduction of bowel, and repair of diaphragmatic defect. (najms.org)
Surgery19
- They are areas of thick connective tissue - fascia - which are for the most part doing a good job in 'holding things together' after injury or surgery. (traumarecoveryclinic.com)
- Please try MFR before undergoing further surgery to "correct" scar tissue appearance - which can result in even more scar tissue! (traumarecoveryclinic.com)
- Almost everyone who has surgery on the abdomen gets adhesions. (medlineplus.gov)
- During minimally invasive surgery, bipolar forceps are used, among other things, for hemostasis and tissue separation. (zeiss.com)
- Surgery may be done to allow normal movement of the organ and reduce symptoms caused by the adhesion. (pituitary.org)
- Scar tissue may make the surgery harder to do through the laparoscope. (peacehealth.org)
- Reduce post surgery adhesions and swelling. (parker.edu)
- The aim of this review was to investigate the efficacy of 4 % icodextrin solution, a widely used adhesion prevention agent, in gynaecological surgery. (bris.ac.uk)
- Secondly, adhesion barriers should be placed in case surgery is performed. (talosintuitivecare.com)
- Thirdly, especially in young patients, surgery should be performed only when needed protecting women from entering the vicious cycle of adhesion formation. (talosintuitivecare.com)
- Robotic surgery, by its precise movements, maximizes our ability to offer high-level services by increasing surgical capabilities that can meticulously and safely take down all adhesions formed. (talosintuitivecare.com)
- The problem with surgery (which, in this example, is just a fancy word for 'cutting') is the formation of scar tissue. (fallopiantubeformula.com)
- Surgery or 'cutting' actually CAUSES scar tissue or adhesions! (fallopiantubeformula.com)
- Prophylactic procedures associated with gynecological surgery for the management of superficial endometriosis and adhesions. (bvsalud.org)
- To provide guidelines from the French College of Obstetricians and Gynecologists (CNGOF), based on the best currently available evidence, for the prophylactic procedures associated with gynecological surgery for benign disease such as superficial endometriosis lesions and adhesions. (bvsalud.org)
- If the condition does not respond to treatment with medication, surgery to remove excess endometrial tissue may be required. (craigranchobgyn.com)
- During surgery, the scar tissue will be removed and tight ligaments, if any, will be dissected. (seanbaranmd.com)
- Following spine surgery, scar tissue usually develops as part of the healing process. (mkkneuro.com)
- Pain due to scar tissue usually develops 6-12 weeks after surgery. (mkkneuro.com)
Organs12
- Sometimes, however, too much scar tissue may develop, and it may pull on other areas, compress nerves, blood vessels and organs and restrict physical movement and physiological functioning. (traumarecoveryclinic.com)
- Normally, internal tissues and organs have slippery surfaces so they can shift easily as the body moves. (medlineplus.gov)
- Adhesions cause tissues and organs to stick together. (medlineplus.gov)
- Biological tissues are composed of various cell types working cooperatively to perform their respective function within organs and the whole body. (cnrs.fr)
- Platelet endothelial cell adhesion molecule 1 ( PECAM-1 /CD31) is one of the human minor histocompatibility antigens that are the main targets of alloreactive T-cells after hematopoietic stem cells or solid organs transplantation . (bvsalud.org)
- Systemic sclerosis (SSc) is a chronic, autoimmune, connective tissue disease, which affects the skin and internal organs. (degruyter.com)
- Endometriosis is an often painful condition in which tissue that normally lines the uterus grows outside the uterus and on organs in the abdomen or pelvis. (bidmc.org)
- Pump oxygen and nutrients into tissues and vital organs, improving circulation . (parker.edu)
- We have designed novel biomimetic cell culture surfaces that imitate the softness of various tissues and organs, allowing the cells to «feel like home» even outside the body. (grstiftung.ch)
- Usually, the lining of the abdominal cavity, which is called the peritoneum, doesn't involve adhesions, and adjusting organs of the abdomen lay one next to the other. (talosintuitivecare.com)
- Secondary lymphoid organs (SLOs) include lymph nodes, spleen, Peyer's patches, and mucosal tissues such as the nasal-associated lymphoid tissue, adenoids, and tonsils. (aai.org)
- Tertiary lymphoid organs (TLOs) or, more accurately, tertiary lymphoid tissues are accumulations of lymphoid cells that arise in the adult. (aai.org)
Focal adhesi3
- RGD-independent cell adhesion to tTG-FN does not require transamidating activity, is mediated by the binding of tTG to cell-surface heparan sulfate chains, is dependent on the function of protein kinase Cα (PKCα) and leads to activation of the cell survival focal adhesion kinase (FAK). (ntu.ac.uk)
- Mechanistic studies showed that MWCNTs induced fibrogenesis of NHLFs through promoting expression and phosphorylation of focal adhesion kinase (FAK), while attenuating intracellular tension in the cells on stiff gels could increase MWCNTs uptake and thus elevate the induced fibrogenic responses. (cdc.gov)
- Focal adhesion kinase (FAK), guanine nucleotide exchange factors (GEF) for Rho and the Rho effector Rho kinase II (ROCKII) are crucial for the regulation of adhesion movement and trailing-edge retraction. (biologists.com)
Abdominal4
- We have treated caesarean scars which are twenty or thirty years old with great success, as well as internal abdominal adhesions, relieving symptoms several years after they first appeared. (traumarecoveryclinic.com)
- Fibrosis and scarring causing abdominal pain, adhesions. (oneradionetwork.com)
- Indeed, we observed proliferation of tissue-resident memory CD4 + T cells and production of IL-17A, IL-22, IFN-γ and TNF-β by cells isolated from abdominal skin explants in response to heat-killed S. aureus . (frontiersin.org)
- This might be in the form of a liquid that causes the dilution of the particles that cause adhesions, hence minimize their formation or even solid components that can be placed on top of surgical incisions and wounds and eventually reduce exposure to the lining of the abdominal cavity. (talosintuitivecare.com)
Anatomic1
- Anatomic defects or infection, adhesions, adnexal masses. (healthnews.com)
Extracellular matrix5
- Matrix metalloproteinases are enzymes that regulate tissue behavior by interactions with extracellular matrix proteins. (ucsf.edu)
- In addition to modulating vascular tone and extracellular matrix turnover, ET-1 up-regulates cell surface adhesion molecules-intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).The aim of the study was to evaluate the diagnostic value of the detection of ET-1, VCAM-1 and ICAM-1 in the diagnosis of systemic sclerosis. (degruyter.com)
- For skin tissue engineering, an ideal scaffold should mimic the natural extracellular matrix of the native skin. (usda.gov)
- This formation helps deposition and adhesion of the extracellular matrix on the bone-implant interface. (bvsalud.org)
- A bioink is essentially a hydrogel biomaterial, containing one or more cell types, nutrients, and growth factors in varying amounts, that mimics the extracellular matrix (ECM) of the tissue and supports the growth of the embedded cells. (sigmaaldrich.com)
Mesenchymal stem2
- Mesenchymal stem cells (MSCs) isolated from bone marrow have the capacity to differentiate into several mesenchymal tissues, including bone, cartilage and adipose tissue. (allconferences.com)
- 2 (2007) observed that cell adhesion and proliferation, as well as the osteogenic differentiation of mouse mesenchymal stem cells (MSCs) to Ti discs were significantly similar to those on the plastic surface of the culture, indicating Ti as an excellent material for repairing hard tissue in the field of bone tissue engineering. (bvsalud.org)
Surfaces6
- Union of two tissue surfaces. (pituitary.org)
- Adhesions are scar-like tissues that form between two surfaces inside the body. (pituitary.org)
- Adhesions can also form between the two surfaces. (pituitary.org)
- These consortiums can colonize a variety of surfaces, such as host tissues, dentures, and catheters, resulting in infections highly resistant to drugs, when compared with their planktonic counterparts. (mdpi.com)
- Aim: To evaluate the adhesion of mouse bone marrow mesenchymal cells (MBMMC) on different titanium surfaces. (bvsalud.org)
- Therefore, the present study aimed to evaluate the adhesion capacity of mouse bone marrow MSCs to smooth and plasmanitrided Ti surfaces in the cathodic cage configuration. (bvsalud.org)
Mucosal tissues2
- C. glabrata and its cousin C. albicans cause infections in blood and in mucosal tissues such as the urinary tract and vagina. (news-medical.net)
- The new study builds on the lab's discovery in 1999 that C. glabrata sticks to cells that line mucosal tissues and blood vessels thanks to the products of genes dubbed EPAs by Cormack's team. (news-medical.net)
Intestine1
- In control group of animals, in which polectomy was not followed by the pouch application ( Fig. 1A, E ), mostly fatty tissue adhesions ( Fig. 1E , 2A & C ) but also pancreas and intestine adhesions (data not shown) were observed. (nature.com)
Uterus5
- Adhesions can sometimes cause infertility in women by preventing fertilized eggs from reaching the uterus. (medlineplus.gov)
- Diagnosis may include pelvic exam, ultrasound, MRI, and in some cases, laparoscopy - a procedure that allows the surgeon to view inside your abdomen to look for endometrial tissue outside the uterus. (bidmc.org)
- It occurs when the endometrium (the tissue that normally lines the uterus) grows beyond the uterus and into other parts of the pelvic area. (craigranchobgyn.com)
- Endometriosis may also be caused by an immune-system disorder that makes the body unable to detect or destroy endometrial tissue growing outside the uterus. (craigranchobgyn.com)
- Septate uterus: This condition happens when tissues part the uterus and create a septum wall in the middle that causes a poor blood supply. (carefultrip.com)
Soft tissue7
- Soft tissue rehabilitation is a mainstay of massage therapy in orthopedic settings. (amtamassage.org)
- But whether due to injuries, overuse or other types of trauma, soft tissue rehabilitation is a mainstay of massage therapy in orthopedic settings and a place for massage therapists to shine. (amtamassage.org)
- Anytime colleagues have someone with soft tissue restriction, they will refer to me because you can't gain strength without motion," she says. (amtamassage.org)
- The soft tissue was healthy and keratinized around the healing abutments when open-tray impression taking was performed after two weeks. (nobelbiocare.com)
- The Gram-positive bacterium Staphylococcus aureus is the leading cause of skin and soft tissue infections globally ( 20 ). (frontiersin.org)
- The body responds to soft-tissue injury (including micro-trauma) by laying down small amounts of scar tissue to repair the injured tissue. (xcelart.com)
- Soft tissue opacity was the most common finding which 243 cases (85.9%) of 283 obstructed nasolacrimal duct and 89 cases (81.7%) of 109 non-obstructed nasolacrimal duct showed it. (ekjo.org)
Pelvis1
- In rare cases, endometrial tissue can spread beyond the pelvis to other areas of the body. (craigranchobgyn.com)
Deep tissue3
- Designed to remove severe tension, deep tissue massage is a technique used to relieve both muscles and connective tissue below the surface. (acuityscheduling.com)
- The goal in deep tissue massage is to breakdown adhesions (tense areas within the muscle). (cntmassagetherapy.com)
- Our line of massage guns offers deep tissue massage benefits that can help you heal, energize, and recover in the comfort of your own home. (gravityforce.ca)
Cellular8
- The goals of the present study were to quantify the penetration of anticancer drugs as a function of cellular adhesion and packing density and to determine the effects of variable penetration on therapeutic efficacy in this model system. (aacrjournals.org)
- We illuminate the many-body effects underlying the structure, formation, and dissolution of cellular adhesion domains in the presence and absence of forces. (semanticscholar.org)
- Most living tissues exhibit the specific stiffness, which has been known to have profound influence on cell behaviors, yet how the stiffness affects cellular responses to engineered nanomaterial s has not been elucidated. (cdc.gov)
- Visible and infrared light have been shown to affect positive therapeutic benefits to living tissues and organisms on a cellular level. (nutrimedical.com)
- Cooperative effects of fibronectin matrix assembly and initial cell-substrate adhesion strength in cellular self-assembly. (rochester.edu)
- Anderson J. M. , Bonfield T. L. , Ziats N. P. Protein adsorption and cellular adhesion and activation on biomedical polymers. (microbiologyresearch.org)
- Less discretely anatomically defined cellular accumulations include the bronchus-associated lymphoid tissue, cryptopatches, and isolated lymphoid follicles. (aai.org)
- Bioinks, bioprinting parameters, and post-bioprinting processing all impact viability and functionality of cells, which in turn affect subsequent cellular events, such as proliferation, differentiation, and tissue formation. (sigmaaldrich.com)
Cell37
- Impaired penetration of anticancer agents through MCLs derived from the tightly packed cell lines and relative resistance to killing of cells within them by doxorubicin treatment strengthen the role of tumor cell adhesion and packing density as contributing to drug resistance. (aacrjournals.org)
- As another important component in nerve tissues, the potential of modulating cell-cell interactions as a strategy to promote regeneration has been overlooked. (ntu.edu.sg)
- Within the central nervous system, there are considerably more cell-cell communications as compared to cell-ECM interactions, since the ECM only contributes 10%-20% of the total tissue volume. (ntu.edu.sg)
- Therefore, modulating cell-cell interactions through cell adhesion molecules (CAMs) such as cadherins, neural cell adhesion molecules (NCAM) and L1, may be a potential alternative to improve nerve regeneration. (ntu.edu.sg)
- tTG-FN supports RGD-independent cell adhesion of different cell types and the formation of distinctive RhoA-dependent focal adhesions following inhibition of integrin function by competitive RGD peptides and function blocking antiintegrin antibodies α5β1. (ntu.ac.uk)
- Association of tTG with its binding site on the 70 kda aminoterminal FN fragment does not support this cell adhesion process, which seems to involve the entire FN molecule. (ntu.ac.uk)
- The tTG-FN complex can maintain cell viability of tTG-null mouse dermal fibroblasts when apoptosis is induced by inhibition of RGD-dependent adhesion (anoikis), suggesting an extracellular survival role for tTG. (ntu.ac.uk)
- We propose a novel RGD-independent cell adhesion mechanism that promotes cell survival when the anti-apoptotic role mediated by RGD-dependent integrin function is reduced as in tissue injury, which is consistent with the externalisation and binding of tTG to fibronectin following cell damage/stress. (ntu.ac.uk)
- Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins? (ucsf.edu)
- The subtle signs of infection, the need to offer stem cell transplantation, and the early deaths in patients with leukocyte adhesion deficiency I that is not properly treated suggest that frequent monitoring by a clinical immunologist is essential. (medscape.com)
- Patients with leukocyte adhesion deficiency I are at risk for graft versus host disease post-stem cell reconstitution, although graft versus host disease has been less common than in other transplantation settings. (medscape.com)
- Without hematopoietic stem cell transplantation (HSCT), patients with leukocyte adhesion deficiency I who have an absence of CD18 expression usually die from infection within 2 years of life. (medscape.com)
- Forced-rupture of cell-adhesion complexes reveals abrupt switch between two brittle states. (semanticscholar.org)
- The resulting contractility related changes at the level of each single cell impact tissue architecture by triggering changes in cell shape, cell movement and remodelling of the surrounding environment. (cnrs.fr)
- Minor histocompatibility antigens in Tunisians: could platelet endothelial cell adhesion molecule 1 marker be one of them? (bvsalud.org)
- Two major thrusts in the last decade have dramatically impacted our understanding of biofilms: the utilization of the confocal laser scanning microscope to characterize biofilm ultrastructure, and an investigation of the genes involved in cell adhesion and biofilm formation. (cdc.gov)
- Although the cell surface repertoire and the gene expression pattern vary among these cells, this is likely a reflection of the tissue of origin or the culture conditions used for maintenance of these cells [ 11 , 12 ]. (hindawi.com)
- While optimal cell environment is directed at a common final goal, the course in attaining tissue specificity must take into account progressive changes that accent the functional development. (allconferences.com)
- Cell adhesion to extracellular matrices through integrin receptors anchors cells and triggers signals that direct cell proliferation and differentiation. (allconferences.com)
- In particular, human skin-resident memory T (Tsrm) cells can be identified through the surface expression of the skin-homing marker cutaneous lymphocyte-associated antigen (CLA), the memory T cell marker CD45RO and the tissue-retention marker CD69. (frontiersin.org)
- Fibroblasts maintained in the absence of serum have stable adhesions within the rear of the cell and exhibit reduced trailing-edge retraction resulting in an elongated cell phenotype. (biologists.com)
- Addition of lysophosphatidic acid (LPA) induced the movement of adhesions and retraction of the trailing edge, thus mimicking tail retraction in a migrating cell. (biologists.com)
- Downregulation of FAK by small interfering RNAs or small hairpin RNAs blocked LPA-induced adhesion movement and restoration of cell shape. (biologists.com)
- Estimating cell concentration in three-dimensional engineered tissues using high frequency quantitative ultrasound. (rochester.edu)
- Tissue-soft culture allows to enhancing cell production by increasing both quantity and quality, two prerequisites necessary for novel therapeutic applications such as cell therapy. (grstiftung.ch)
- To date, we have successfully developed silicone-based substrates with tissue-like stiffness for cell culture applications. (grstiftung.ch)
- The multifunctional polymer coating adhered strongly to our soft substrates and enabled cell adhesion, growth and differentiation. (grstiftung.ch)
- It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. (embl.de)
- The term "adhesion" to the biomaterial refers to the most important phase, since the quality of it will influence morphology and the capacity of cell proliferation and differentiation 3 . (bvsalud.org)
- Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
- Hematopoetic Stem Cell Transplantation in Neutrophil Disorders: Severe Congenital Neutropenia, Leukocyte Adhesion Deficiency and Chronic Granulomatous Disease. (medscape.com)
- Leukocyte Adhesion Deficiency Type III: Clinical Features and Treatment With Stem Cell Transplantation. (medscape.com)
- Nonmyeloablative hematopoietic stem cell transplantation corrects the disease phenotype in the canine model of leukocyte adhesion deficiency. (medscape.com)
- Heukelekian and genes involved in cell adhesion and biofilm formation. (cdc.gov)
- This study demonstrates some potential for the approach to yield an implantable biphasic construct, but further development is required to improve cell-scaffold adhesion. (openorthopaedicsjournal.com)
- The bioink should not only provide structural, physical, and mechanical support to the embedded cells, but also supply them with the essential biological and chemical cues for cell survival, proliferation, and differentiation required for tissue morphogenesis and homeostasis. (sigmaaldrich.com)
- tein, and neuronal cell adhesion molecule mRNA were also increased in olfactory bulb. (cdc.gov)
Endothelial cells2
- Systemic sclerosis causes increased expression of adhesion molecules on the surface of endothelial cells. (degruyter.com)
- These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
Blood vessels1
- The papillary dermis, closer to the epidermis and in contact with the basal lamina, forms the dermal papillae and it is connective tissue with abundant blood vessels for feeding the epidermis, but also for body temperature regulation by vasodilation and vasoconstriction. (uvigo.es)
SURGICAL4
- In rodent models, extrarenal tissues adhere to surgical kidney wound and interfere with healing. (nature.com)
- Second, the surgical kidney injury in rodent models is technically complicated by the tendency of extrarenal tissues to adhere to the wound and interfere with the healing. (nature.com)
- The surgical instrument reduces tissue adhesion and allows a clear view of the coagulation for efficient preparation. (zeiss.com)
- Post-surgical adhesions are common and can cause substantial co-morbidity. (bris.ac.uk)
Differentiation2
- Additionally, selected tubules of the wounded kidney extended into the granulation tissue forming branching tubular epithelial outgrowths (TEOs) without terminal differentiation. (nature.com)
- In the pouch model, tubules of the injured kidney repaired outside of the kidney parenchyma in the surrounding granulation tissue and formed branching tubular epithelial structures lacking terminal differentiation. (nature.com)
Reduce5
- These new disposable bipolar forceps are made from a special copper-base alloy and potentially reduce tissue adhesion and subsequent charring during dissection of tissue. (zeiss.com)
- Our copper-base alloy has superior thermal conduction to improve cautery-based hemostasis and reduce tissue adhesion," emphasizes Michael T. Lawton, MD, President and CEO, Chair, Department of Neurosurgery, Barrow Neurological Institute, Phoenix/Arizona (USA). (zeiss.com)
- Reduce the excitability of nervous tissue. (nutrimedical.com)
- Reduce painful trigger points.Promote mobility and range of motion and also improve mature scar tissue. (acuityscheduling.com)
- It also increases blood flow and circulation to the affected areas, which helps the body break down the toxins which cause dimply skin.The massage entails long, gentle, rhythmic strokes to increase the flow of lymph and reduce toxins in your body.Lymphatic drainage massage can improve your skin texture by speeding up healing in scar tissue. (acuityscheduling.com)
Tumor5
- The development of multicellular layers (MCLs), in which tumor cells are grown on a semipermeable Teflon support membrane, has facilitated quantification of drug penetration through solid tissue. (aacrjournals.org)
- The proposed mechanisms of drug resistance in cancer are based largely on the study of drug-resistant variants isolated from tumor cells exposed to various classes of drugs in monolayer tissue culture. (aacrjournals.org)
- To reach cancer cells in optimal quantities, a therapeutic agent must be delivered to a tumor through its imperfect blood vasculature, cross vessel walls into the interstitium, and penetrate multiple layers of solid tissue. (aacrjournals.org)
- RECK, a membrane-anchored inhibitor of MMPs was recently characterized for its role in development, tissue homeostasis, and for tumor angiogenesis. (ucsf.edu)
- More specifically, we are studying the expression of endothelial adhesion molecules and chemokines in unaffected and tumor tissues, and how these shape the repertoire of tumor-infiltrating lymphocytes. (gu.se)
Fibrous2
- A scar is often made of fibrous tissue. (altonmemorialhospital.org)
- It may cause fibrous adhesion of the nerve roots within the spinal canal leading to pain. (mkkneuro.com)
Dense irregu1
- The deeper part of the dermis is known as reticular dermis, which is dense irregular connective tissue with fewer cells, compared to papillary dermis. (uvigo.es)
Fascia4
- I am frequently asked why I have so much information on my site about FASCIA , as well as one of the chief problems that occurs within this tissue - FASCIAL ADHESIONS / SCAR TISSUE / FIBROSIS . (doctorschierling.com)
- Because fascia is arguably the single most pain-sensitive tissue in the body. (doctorschierling.com)
- This type of massage is extremely beneficial because it reaches the deepest layer of muscles, fascia (connective tissue surrounding the joints) and tendons. (cntmassagetherapy.com)
- As the muscles and fascia of the foot become strained and develop adhesions, they become very tight. (xcelart.com)
Fallopian2
- Studies suggest that adhesions may block the fallopian tubes and prevent fertilization. (talosintuitivecare.com)
- And when we are trying to eliminate scar tissue and adhesions in our delicate, thin-as spaghetti-strand fallopian tubes, this is a double-edged sword and an unnecessary risk, in my opinion. (fallopiantubeformula.com)
Blockage2
- Scar tissue may form inside the pelvic region causing blockage and pain. (americanpregnancy.org)
- This may create intrauterine adhesions with partial or total blockage of the endometrial cavity. (healthnews.com)
Bacterial4
- Earlier reviews of leukocyte adhesion deficiency I indicated that unreconstituted patients most often succumbed to bacterial infections. (medscape.com)
- Pre-incubation of bacterial cells with Vn significantly reduced subsequent adhesion to polystyrene precoated with Vn 0.5 μg / well. (microbiologyresearch.org)
- When PVC pre-exposed to CSF was incubated with antibodies to Vn, subsequent bacterial adhesion of a Vn-binding strain, S. epidermidis 5703, was significantly reduced. (microbiologyresearch.org)
- Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
Benign2
- Although successful complete immune reconstitution from bone marrow transplantation is reported using fully matched related and unrelated donors or haploidentical donors (ie, parents), patients with leukocyte adhesion deficiency I cannot be guaranteed to have benign courses. (medscape.com)
- These adhesions are usually benign, and often resolve without any intervention. (healthline.com)
Reduces2
- In addition, SLIT2 stimulation inhibits NMIIA activity, decreases focal adhesion formation, and reduces podocyte attachment to collagen. (nih.gov)
- Although all tissues optimize a structure that reduces strain, individual morphology of the tissues reflects different strategies to attain this condition. (allconferences.com)
Formation8
- Specific association of tissue transglutaminase (tTG) with matrix fibronectin results in the formation of an extracellular complex (tTG-FN) with distinct adhesive and prosurvival characteristics. (ntu.ac.uk)
- Histological analysis demonstrates that application of the pouch effectively prevented formation of adhesions and induced characteristic wound healing manifested by formation of granulation tissue. (nature.com)
- Scar tissue formation (adhesions). (peacehealth.org)
- Leonova and Raphael (1997) reported that the adhesion molecule, E-cadherin, alters distribution patterns resulting from scar tissue formation in the cochlea after administration of kanamycin. (cdc.gov)
- They speculated that E-cadherin may play an important role in the transmission of sound and the process of the scar tissue formation in the cochlea after ototoxic drug administration. (cdc.gov)
- The reason for the formation of adhesions is not always known. (talosintuitivecare.com)
- During operating procedures, specific techniques can be used to prevent the formation of adhesions. (talosintuitivecare.com)
- Adhesion formation can have a detrimental effect on family planning and infertility as well. (talosintuitivecare.com)
Regeneration6
- Following that, we will discuss existing tissue engineering approaches that utilize CAMs and biomaterials to control nerve regeneration. (ntu.edu.sg)
- Additionally, in the kidney wound protected from adhesions by the pouch, we observed a novel pattern of tubular regeneration distinct from tubular regeneration described in ATN. (nature.com)
- equipment offers 7 specific settings to promote different levels of tissue healing and regeneration. (nutrimedical.com)
- Promote tissue regeneration, reducing scar tissue and stretch marks . (parker.edu)
- Accordingly, the association of Ti implants with bone tissue culture may contribute to bone tissue regeneration 7 . (bvsalud.org)
- The purpose of this study was to conduct a preliminary investigation into a new tissue engineering approach to osteochondral regeneration. (openorthopaedicsjournal.com)
Involve1
- It can also involve a connection between the shaft skin and the coronal margin, or an adhesion between the skin of the shaft and the glans, or head, of the penis. (healthline.com)
Connective tissue d1
- Despite the progress made over the last decade in SSc diagnosis and treatment, disability and mortality from SSc remain the highest among all connective tissue diseases. (degruyter.com)
Wound3
- We performed thorough comparative histological analysis of the wound healing with and without the interference of adhering tissues. (nature.com)
- A defect in a guanosine triphosphate (GTP)-binding protein, Rac2, which is integral to actin-associated neutrophil responses and to the generation of superoxide by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, leads to a clinical syndrome resembling Leukocyte adhesion deficiency with prolonged cord attachment, perirectal cellulitis, and omphalitis associated with marked leukocytosis and poor wound healing. (medscape.com)
- anti-adhesion (prevention of bacteria from sticking to the wound, mucous membranes, etc. (ship2world.co)
Mediate1
- The study shows that Vn may mediate adhesion of CNS in the presence of CSF. (microbiologyresearch.org)
Resection2
- We use tissue resection material from cancer patients and blood from volunteers, and also use a spontaneous mouse model of colon cancer. (gu.se)
- In order to perform these studies, we use tissue resection material from cancer patients and blood from volunteers, and also use a spontaneous mouse model of colon cancer. (gu.se)
Body's2
- Scar Tissue and Adhesions are the body's own mechanism for healing areas which have been physically cut or torn in the body. (traumarecoveryclinic.com)
- This means that one of the most potentially pain-sensitive tissues is also one of the body's most abundant, but cannot be seen with our current imaging technology ( AT LEAST NOT WITH THE MOST COMMONLY-USED TECHNOLOGY ). (doctorschierling.com)
Protein3
- Here we report that a potentially novel signaling pathway consisting of SLIT/ROBO Rho GTPase activating protein 1 (SRGAP1) and nonmuscle myosin IIA (NMIIA) regulates podocyte adhesion downstream of ROBO2. (nih.gov)
- Collagen is the essential protein used to repair damaged tissue and to replace old tissue. (nutrimedical.com)
- Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
Endometriosis2
- pelvic inflammatory disease from sexually transmitted infections or scar tissue from endometriosis. (healthnews.com)
- With endometriosis, displaced endometrial tissue continues to act as it normally would - responding to hormones, it thickens, breaks down and bleeds with each menstrual cycle. (bidmc.org)
Injury2
- The fact of the matter is scar tissue is a normal healing response from the body whenever trauma or injury occurs. (fallopiantubeformula.com)
- The reasons for this injury are largely unknown but 'adhesion' (scar tissue) begins forming in the joint capsule. (theosteopath.net)
Biomaterials2
- Quantitative Ultrasound for Nondestructive Characterization of Engineered Tissues and Biomaterials. (rochester.edu)
- The selection of proper biomaterial (or combination of biomaterials) for a bioink is a key step for successful bioprinting of tissues, and it depends on several factors such as the bioprinting modality to be used, the tissue of interest, and any post-printing processes that are required. (sigmaaldrich.com)
Ligaments1
- This can lead to injuries like stiff and sore joints, tendons, ligaments and connective tissues which can be alleviated and managed by increasing flexibilty and good blood circulation though the aid of such a device. (massagerzone.com)
Molecules2
- Determination of soluble adhesion molecules and ET-1 in serum SSc patients could be one of the laboratory markers for evaluating SSc activity and disease prognosis. (degruyter.com)
- It should expedite the natural process of healing by facilitating the breakdown of inflammatory molecules and helping with the process of remodelling scar tissue from its rough copies to its better copies. (enerex.ca)
Defect2
- Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)
- Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter. (medscape.com)
Painful1
- Penile adhesions and skin bridges can sometimes become somewhat painful if left untreated. (healthline.com)
Infection3
- Smegma isn't a sign of infection, but it may suggest a need for better hygiene and treatment of any adhesions. (healthline.com)
- These leukocyte adhesion deficiencies (LADs) are unlikely to be confused with hyperimmunoglobulin E syndrome or chronic granulomatous disease because the clinical features of infection resemble those manifested by patients with severe neutropenia despite marked neutrophilia. (medscape.com)
- The initial tissue reaction to infection is a focal, intensely suppurative necrosis consisting largely of accumulations of polymorphonuclear leukocytes, followed by invasion of macrophages, epithelioid cells, and lymphocytes. (cdc.gov)
Behavior1
- These properties determine the adhesion and behavior of cells in contact with the surface. (bvsalud.org)
Pain11
- As I showed you YESTERDAY , I do things very differently in my clinic, with a huge emphasis on the integrity of connective tissues (or lack thereof) as a potential source of pain - particularly CHRONIC PAIN . (doctorschierling.com)
- While I am not against any of these things (in fact I am very much for them), as I have discussed repeatedly, the FIRST STEP in solving any number of chronic pain issues is " UNTETHERING " the microscopic adhesions. (doctorschierling.com)
- But also realize that for every person with severe trigger points, there are many many more who have Fascial Adhesions, which are rarely dealt with in the peer-review, even though there are brilliant mainstream scientists and physicians who believe that fouled up connective tissues are the starting point for all (that's 'all' as in all) pain syndromes, sickness, and disease ( HERE ). (doctorschierling.com)
- With more than 300 individual joints in the human body, pain and dysfunction in the tissues and muscles surrounding those joints is a common problem. (amtamassage.org)
- MRI or ultrasound might miss the diagnosis of adhesions in a patient with chronic pelvic pain. (talosintuitivecare.com)
- These adhesions can also result in pain. (endosupp.com)
- When endometrial tissue grows outside the uterine wall, it can swell and form scar tissue, causing pain and discomfort. (craigranchobgyn.com)
- As the tightness increases, the tissues begin to pull away from the heel where they attach, which will eventually lead to pain and irritation at the bottom of the heel. (xcelart.com)
- In addition to causing pain and tightness these, adhesions are also very sticky, affecting the ability of the muscles to stretch, contract, and slide over one another. (xcelart.com)
- Pain can sometimes increase during this period due to swelling of the tissues around the nerve root after the operation. (mkkneuro.com)
- Tissue engineering is an experimental treatment alternative with the potential to regenerate healthy hyaline cartilage tissue, alleviate pain, and restore normal function. (openorthopaedicsjournal.com)
Abdomen1
- Adhesions are bands of scar tissue formed inside the abdomen. (talosintuitivecare.com)