A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
Analogs or derivatives of prostaglandins F that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGF.
The pressure of the fluids in the eye.
A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.
A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.
AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics.
Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.
A synthetic prostaglandin F2alpha analog. The compound has luteolytic effects and is used for the synchronization of estrus in cattle.
The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)
A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
Compounds obtained by chemical synthesis that are analogs or derivatives of naturally occurring prostaglandins and that have similar activity.
Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics.
The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.
A cytosolic carbonic anhydrase isoenzyme primarily expressed in ERYTHROCYTES, vascular endothelial cells, and the gastrointestinal mucosa. EC 4.2.1.-
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986)
A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.
The cutting of or surgical operation on a living animal, usually for physiological or pathological investigation. (from Merriam-Webster's Collegiate Dict, 10th ed)
A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).
Individuals enrolled in a school of pharmacy or a formal educational program leading to a degree in pharmacy.
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Techniques for measuring blood pressure.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
Use of plants or herbs to treat diseases or to alleviate pain.
Methods or procedures used to obtain samples of URINE.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
Function of the human eye that is used in dim illumination (scotopic intensities) or at nighttime. Scotopic vision is performed by RETINAL ROD PHOTORECEPTORS with high sensitivity to light and peak absorption wavelength at 507 nm near the blue end of the spectrum.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
Apparatus, devices, or supplies intended for one-time or temporary use.
Services providing pharmaceutic and therapeutic drug information and consultation.
Accidental or deliberate use of a medication or street drug in excess of normal dosage.
People who take drugs for a non-therapeutic or non-medical effect. The drugs may be legal or illegal, but their use often results in adverse medical, legal, or social consequences for the users.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Disorders related to substance abuse.

Central injections of capsaicin cause antidiuresis mediated through neurokinin-1 receptors in rat hypothalamus and vasopressin release. (1/309)

Intracerebroventricular injections of capsaicin at 100-500 nmol elicited dose-dependent decreases in urine outflow volume in anesthetized, hydrated rats. The capsaicin (500 nmol)-induced antidiuresis was inhibited by pretreatment with CP96345 (30 nmol, a neurokinin-1-receptor antagonist), but not by that with phenoxybenzamine (20 nmol, an alpha-adrenoceptor antagonist), timolol (100 nmol, a beta-adrenoceptor antagonist) or atropine (300 nmol, a muscarinic antagonist) into the hypothalamic supraoptic nucleus (SON). Intravenous injections of d(CH2)5-D-Tyr(Et)VAVP (50 microg/kg, a vasopressin-receptor antagonist) completely blocked the antidiuresis. In intra-SON microdialysis experiments, acetylcholine concentration in the perfusate of the capsaicin-injected rats was not different from that of the vehicle-injected rats. These findings suggested that capsaicin stimulated substance P release in the SON and caused the antidiuresis as a result of the increased release of vasopressin into the circulation from the neurohypophysis mediated through neurokinin-1 receptors in the SON.  (+info)

Mitigation of caffeine-induced fetopathy in mice by pretreatment with beta-adrenergic blocking agents. (2/309)

In a previous experiment, fetopathic effects of caffeine were significantly reduced by pretreatment with propranolol at dosage levels of 2.5 to 10 mg/kg. The present experiments were undertaeken to investigate the relation between time intervals of propranolol pretreatment and its effect on reducing fetopathy. Furthermore, the effect of timolol, another beta-adrenergic blocking agent, on reducing fetopathy was compared with that of propranolol. Propranolol (5 mg/kg) administered 15, 30 or 60 minutes before caffeine treatment significantly reduced the caffeine-induced fetopathy. The optimal effect was found when propranolol was given 30 minutes before caffine. The reduction in fetopathy by timolol pretreatment was comparable to that of propranolol. The results lend support to the hypothesis that the fetopathic effect of caffeine is linked with released catecholamines in material or fetal issues of mice.  (+info)

Constitutively active mutants of the beta1-adrenergic receptor. (3/309)

We provide the first evidence that point mutations can constitutively activate the beta(1)-adrenergic receptor (AR). Leucine 322 of the beta(1)-AR in the C-terminal portion of its third intracellular loop was replaced with seven amino acids (I, T, E, F, C, A and K) differing in their physico-chemical properties. The beta(1)-AR mutants expressed in HEK-293 cells displayed various levels of constitutive activity which could be partially inhibited by some beta-blockers. The results of this study might have interesting implications for future studies aiming at elucidating the activation process of the beta(1)-AR as well as the mechanism of action of beta-blockers.  (+info)

Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with beta adrenergic antagonists. French Latanoprost Study Group, and the Swedish Latanoprost Study Group. (4/309)

AIMS: To compare the effect on intraocular pressure (IOP) of latanoprost monotherapy and timolol-pilocarpine in patients with glaucoma or ocular hypertension with inadequately controlled IOP on topical beta adrenergic antagonists. METHODS: This was a multicentre, randomised, observer masked, 6 week study performed in France and Sweden. 23 centres enrolled 237 patients with glaucoma or ocular hypertension and an IOP of at least 22 mm Hg on treatment with topical beta adrenergic antagonists, alone or in combination. After a 21 day run in period on timolol 0.5% twice daily, patients were randomised either to latanoprost 0.005% once daily or to a fixed combination of timolol-pilocarpine twice daily. Changes in mean diurnal IOP from the baseline to the 6 week visit were determined with an analysis of covariance. RESULTS: Mean diurnal IOP was statistically significantly decreased from baseline in both groups (p<0.001). Switching to latanoprost treatment reduced mean diurnal IOP by 5.4 (SEM 0.3) mm Hg (ANCOVA -22%) and switching to timolol-pilocarpine treatment reduced mean diurnal IOP by 4.9 (0.4) mm Hg (-20%). Blurred vision, decreased visual acuity, decreased twilight vision, and headache were statistically significantly more frequent in the timolol-pilocarpine group. CONCLUSIONS: Latanoprost monotherapy was at least as effective as fixed combination timolol-pilocarpine twice daily treatment in reducing mean diurnal IOP in patients not adequately controlled on topical beta adrenergic antagonists. Latanoprost was better tolerated than timolol-pilocarpine regarding side effects. These results indicate that a switch to latanoprost monotherapy can be attempted before combination therapy is initiated.  (+info)

Effects of topical nipradilol, a beta blocking agent with alpha blocking and nitroglycerin-like activities, on intraocular pressure and aqueous dynamics in humans. (5/309)

AIMS: To study the effects of topical nipradilol, a non-selective beta blocker with alpha blocking and nitroglycerin-like activities, on intraocular pressure (IOP) and aqueous humour dynamics in normal humans and in patients with ocular hypertension. METHODS: Nipradilol (0.06%, 0.125%, 0.25%, 0.5%) was applied to normal volunteers (n = 12) to test for IOP lowering effects. In a second group of normal volunteers (n = 11), nipradilol (0.125% and 0.25%) and timolol (0. 5%) were compared for IOP lowering effects. After a single administration of 0.25% nipradilol, IOP, flare intensity in the anterior chamber, aqueous flow, uveoscleral outflow, tonographic outflow facility, and episcleral venous pressure were either directly measured or mathematically calculated. Topical nipradilol (0.25%) was administered to 24 patients with ocular hypertension twice daily for 8 weeks. RESULTS: Administration of 0.25% nipradilol decreased IOP with a maximum reduction of 4.2 mm Hg lasting 12 hours. A single instillation of both 0.25% nipradilol and 0.5% timolol reduced the IOP in normotensive human subjects to the same degree. A single instillation of 0.25% nipradilol decreased the aqueous flow rate in the treated eye by 20%. Nipradilol produced no significant effect in tonographic outflow facility or episcleral venous pressure, but uveoscleral outflow was increased. In patients with ocular hypertension, twice daily instillation of 0.25% nipradilol decreased IOP without tachyphylaxis for the 8 week test period. CONCLUSION: Topical nipradilol (0.25%) reduced IOP by decreasing the aqueous flow rate and probably also by increasing uveoscleral outflow. Nipradilol should be further investigated as a new antiglaucoma drug.  (+info)

Meal-induced insulin secretion in dogs is mediated by both branches of the autonomic nervous system. (6/309)

We investigated the relationship between autonomic activity to the pancreas and insulin secretion in chronically catheterized dogs when food was shown, during eating, and during the early absorptive period. Pancreatic polypeptide (PP) output, pancreatic norepinephrine spillover (PNESO), and arterial epinephrine (Epi) were measured as indexes for parasympathetic and sympathetic nervous activity to the pancreas and for adrenal medullary activity, respectively. The relation between autonomic activity and insulin secretion was confirmed by autonomic blockade. Showing food to dogs initiated a transient increase in insulin secretion without changing PP output or PNESO. Epi did increase, suggesting beta(2)-adrenergic mediation, which was confirmed by beta-adrenoceptor blockade. Eating initiated a second transient insulin response, which was only totally abolished by combined muscarinic and beta-adrenoceptor blockade. During absorption, insulin increased to a plateau. PP output showed the same pattern, suggesting parasympathetic mediation. PNESO decreased by 50%, suggesting withdrawal of inhibitory sympathetic neural tone. We conclude that 1) the insulin response to showing food is mediated by the beta(2)-adrenergic effect of Epi, 2) the insulin response to eating is mediated both by parasympathetic muscarinic stimulation and by the beta(2)-adrenergic effect of Epi, and 3) the insulin response during early absorption is mediated by parasympathetic activation, with possible contribution of withdrawal of sympathetic neural tone.  (+info)

Betaxolol, a beta(1)-adrenoceptor antagonist, reduces Na(+) influx into cortical synaptosomes by direct interaction with Na(+) channels: comparison with other beta-adrenoceptor antagonists. (7/309)

Betaxolol, a beta(1)-adrenoceptor antagonist used for the treatment of glaucoma, is known to be neuroprotective in paradigms of ischaemia/excitotoxicity. In this study, we examined whether betaxolol and other beta-adrenoceptor antagonists interact directly with neurotoxin binding to sites 1 and 2 of the voltage-sensitive sodium channel (Na(+) channel) in rat cerebrocortical synaptosomes. Betaxolol inhibited specific [(3)H]-batrachotoxinin-A 20-alpha-benzoate ([(3)H]-BTX-B) binding to neurotoxin site 2 in a concentration-dependent manner with an IC(50) value of 9.8 microM. Comparison of all the beta-adrenoceptor antagonists tested revealed a potency order of propranolol>betaxolol approximately levobetaxolol>levobunolol approximately carteolol>/=timolol>atenolol. None of the drugs caused a significant inhibition of [(3)H]-saxitoxin binding to neurotoxin receptor site 1, even at concentrations as high as 250 microM. Saturation experiments showed that betaxolol increased the K(D) of [(3)H]-BTX-B binding but had no effect on the B(max). The association kinetics of [(3)H]-BTX-B were unaffected by betaxolol, but the drug significantly accelerated the dissociation rate of the radioligand. These findings argue for a competitive, indirect, allosteric mode of inhibition of [(3)H]-BTX-B binding by betaxolol. Betaxolol inhibited veratridine-stimulated Na(+) influx in rat cortical synaptosomes with an IC(50) value of 28. 3 microM. Carteolol, levobunolol, timolol and atenolol were significantly less effective than betaxolol at reducing veratridine-evoked Na(+) influx. The ability of betaxolol to interact with neurotoxin site 2 of the Na(+) channel and inhibit Na(+) influx may have a role in its neuroprotective action in paradigms of excitotoxicity/ischaemia and in its therapeutic effect in glaucoma.  (+info)

Effects of glaucoma medications on the cardiorespiratory and intraocular pressure status of newly diagnosed glaucoma patients. (8/309)

AIMS: To evaluate the short term cardiovascular, respiratory, and intraocular pressure (IOP) effects of four glaucoma medications in newly diagnosed glaucoma patients. METHODS: 141 newly diagnosed glaucoma patients were recruited and underwent a full ocular, cardiovascular, and respiratory examination, including an electrocardiogram (ECG) and spirometry. They were prescribed one of four topical glaucoma medications and reviewed 3 months later. One eye of each patient was randomly chosen for analysis, performed using analysis of variance and the chi(2) test. RESULTS: Latanoprost had the greatest mean IOP lowering effect in both the primary open angle glaucoma (POAG) (p = 0.005) and the "presumed" normal tension glaucoma (NTG) groups (p = 0.33), reducing the IOP by 8.9 mm Hg and 4.1 mm Hg respectively. Timolol was associated with lowered pulse rates and reductions in the spirometry measurements. 41% of patients using brimonidine complained of systemic side effects and over 55% of patients using betaxolol complained of ocular irritation. 28% of patients required an alteration in their glaucoma management. CONCLUSIONS: Latanoprost appears to be a useful primary treatment for glaucoma patients, in view of superior IOP control and a low incidence of local and systemic side effects. Timolol causes a reduction in measurements of respiratory function, a concern in view of the potential subclinical reversible airways disease in the elderly glaucoma population. Brimonidine is associated with substantial, unpredictable systemic side effects and betaxolol causes ocular irritation and weak IOP control. Spirometry is advised in all patients receiving topical beta blocker therapy to control their glaucoma.  (+info)

Sandoz Latanoprost/Timolol: This is a combination product containing two different medications: latanoprost and timolol. Latanoprost belongs to a class of medications called prostaglandin analogs. It works to reduce the pressure in the eye by allowing fluid in the eye to flow better. Timolol belongs to a class of medications called beta-adrenergic receptor blockers (also known as beta-blockers). Latanoprost - timolol solution is available in an eye-drop form. It is used to reduce the pressure inside the eye for people with open-angle glaucoma or intraocular hypertension (increased pressure in the eye).
ACT Latanoprost/Timolol: This is a combination product containing two different medications: latanoprost and timolol. Latanoprost belongs to a class of medications called prostaglandin analogs. It works to reduce the pressure in the eye by allowing fluid in the eye to flow better. Timolol belongs to a class of medications called beta-adrenergic receptor blockers (also known as beta-blockers). Latanoprost - timolol solution is available in an eye-drop form. It is used to reduce the pressure inside the eye for people with open-angle glaucoma or intraocular hypertension (increased pressure in the eye).
Buy Timolol Eye Drops online for the treatment of glaucoma or ocular hypertension from our authentic pharmacy store and get it delivered at your desired place.
Side effects inherent to systemic beta-blockers make propranolol contraindicated in patients with certain cardiac and pulmonary conditions. Due to systemic absorption, topical beta-blockers such as timolol maleate, which are used as anti-glaucoma agents, have similar contraindications. The follow report describes an ocular hypertensive patient who was switched from timolol maleate to latanoprost because of a newly diagnosed possibility of mild COPD. The patient developed a bilateral hand tremor, which was previously blocked by systemic absorption of the topical beta-blocker. Included are classification, differential diagnosis and treatment of essential tremor, as well as a review of the mechanism of action and contraindications of timolol maleate and latanoprost.
Aim: To compare the long term (6 months) effect of once daily dose of Timolol in Gel Forming Solution (GFS) with twice daily dose of Timolol in aqueous solution, in control of Intra Ocular pressure (IOP), in cases of Primary Open Angle Glaucoma (POAG). Material and methods: In a Prospective, Randomized Clinical trial, POAG or Ocular Hypertension patients diagnosed between April 2008 and September 2012 were studied. 750 eyes of 600 patients with age group 46-79 yrs. were selected. Diurnal variation of Tension (DVT) was done along with other investigations. Patients were divided into two groups A and B randomly. Group A was started on Timolol twice daily and group B on once daily Timolol GFS. 400 eyes of 310 patients were started on Timolol solution eye drops twice a day.120 eyes of 100 patients were lost to follow-up or unresponsive to timolol (8 eyes of 5 patients). 350 eyes of 290 patients were started on Timolol GFS once daily, of which 70 eyes of 50 patients were lost to follow up or ...
1 Answer - Posted in: pain, timolol, hypertension - Answer: It can cause the dizziness and ear ringing. It can cause paresthesias but ...
Methods: A prospective study was carried out in patients with primary open angle glaucoma (IOP one eye≥ 18 mmHg and ≤30 mmHg and IOP both eyes ≤30 mmHg).The IOP was measured continuously at 15 days, 1 month, 2 months, 3 months, 4 months, 5 months and 6 months after initiation of treatment with timolol 0.5% twice a day, timolol 0.5% twice a day and travoprost 0.004% once daily, and timolol 0.5%/travoprost 0.004% fixed combination once daily ...
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Purpose: : To study the safety of fixed-combination latanoprost/timolol (FCLT) in patients requiring additional intraocular pressure (IOP) reduction over 5 years. Methods: : This was an open-label, phase 3b, multicenter safety study of FCLT in subjects with OAG/OH insufficiently responsive to β-blockers and requiring additional IOP reduction. Subjects ≥18 years age with OAG/OH and prostaglandin naive were evaluated at eleven 6-monthly visits. Safety endpoints were incidence of increased iris pigmentation (IIP) in at least 1 eye, changes in periorbital skin or eyelashes, and occurrence of ocular/periorbital adverse events (AEs) and of serious AEs (SAEs). IIP and changes in eyelashes were assessed by a masked reader from iris and en face photographs (IRIS system) taken at baseline and at years 1, 3, and 5 and by subjects and investigators at each visit. Incidence of IIP was compared to historical controls from a similarly designed study (Alm A, et al. Arch Ophthalmol 2004;122:957-65). Results: ...
Timolol - Get up-to-date information on Timolol side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Timolol
Generic Cosopt is used to treat certain types of glaucoma and other causes of high pressure inside the eye. Dorzolamide reduces the amount of fluid in the eye, which decreases pressure inside the eye. Timolol is a beta-blocker that also reduces pressure inside the eye.. Generisch Cosopt (Dorzelamidel - Timolol Maleate 2% + 0.5% 5ml) € 31.35 Pille - Augepflege @ Canadian online pharmacy. Cheap Canadian online pharmacy
PURPOSE: To evaluate the effects at 1 year of preservative-free timolol gel and preserved timolol eye drops on conjunctiva and tear parameters. METHODS: Forty patients with primary open-angle glaucoma or ocular hypertension were randomized to the two treatment groups and compared with 20 healthy age-matched controls. Clinical tests (IOP, Schirmer I test, and lacrimal film break-up time BUT) and in vivo conjunctival confocal microscopy (IVCM) were performed in all patients at baseline and after 12 months. IVCM (HRT II Rostock Cornea Module; Heidelberg Engineering GmbH, Heidelberg, Germany) was performed after topical anaesthesia in the four cardinal locations and at the corresponding limbus to analyse conjunctiva cells. The main IVCM outcomes were goblet cell density and epithelial regularity. RESULTS: IVCM and clinical parameters were similar in the three groups at baseline. After 12 months, intra-epithelial goblet cell density was significantly lower in the preserved (48.25 ± 7.70) than in the ...
The purpose of this research is to compare the histological and immunohistochemical changes induced by fixed combinations of timolol maleate and prostaglandin analogues in the rabbit conjunctiva. Thirty left eyes of rabbits, divided into three groups, were treated for 30 days with the following combinations of drugs: bimatoprost 0.03% + timolol 0.5%, travoprost 0.004% + timolol 0.5% and latanoprost 0.005 + timolol 0.5%. The right eyes served as controls and received no medication. At the end of the experiment, after enucleation, the conjunctivas were assessed through histomorphometry (number of inflammatory and goblet cells, epithelial thickness) and immunohistochemistry (anti-actin antibody to assess the degree of fibrosis). Histomorphometrically, there was infiltration of inflammatory cells in all the treated eyes. An increased number of goblet cells was observed with the use of all fixed combinations of prostaglandin analogues associated with timolol maleate in comparison with the control group. The
Question posted in: glaucoma, insomnia, timolol - Additional details: ... timolol be the cause? I have been using timolol off and on for a couple of ...
1.. Walia HS, Walia SS, Emanuel ME.Sick sinus syndrome associated with topical timolol maleate instillation. Journal of Pharmacology and Pharmacotherapeutics 2: 300-302, No. 4, Oct-Dec 2011. Available from: URL: http://dx.doi.org/10.4103/0976-500X.85946 - USA ...
VYZULTA® vs. Timolol Study: Non-Inferior & Superior to Timolol 0.5% (32% Mean Diurnal IOP Reduction) The efficacy and safety of VYZULTA were evaluated in two randomized, multi-center, double-masked, parallel-group Phase 3 studies, APOLLO and LUNAR, comparing VYZULTA with timolol maleate ophthalmic solution 0.5% in subjects (N=831) with open-angle glaucoma or ocular hypertension. The primary objective of these studies was to demonstrate that the mean IOP reduction over 3 months of treatment with VYZULTA once daily (QD) in the evening was non-inferior to timolol 0.5% twice daily (BID). A secondary objective was to demonstrate the superiority of VYZULTA QD to timolol 0.5% BID. In both studies, VYZULTA met the primary efficacy endpoint. VYZULTA also demonstrated significantly greater IOP lowering than timolol 0.5% throughout the day at 3 months of treatment resulting in a reduction in mean diurnal IOP of 32% from baseline.2,3,4 The most common ocular adverse events included conjunctival hyperemia ...
TY - JOUR. T1 - Evaluation of retinal haemodynamics and retinal function after application of dorzolamide, timolol and latanoprost in newly diagnosed open-angle glaucoma patients. AU - Arend, Oliver. AU - Harris, Alon. AU - Wolter, Pia. AU - Remky, Andreas. PY - 2003/10/1. Y1 - 2003/10/1. N2 - Purpose: The purpose of this prospective, randomized, cross-over study was to investigate and compare the microcirculatory effects of timolol, dorzolamide and latanoprost in newly diagnosed primary open-angle glaucoma (POAG) patients. Haemodynamics were assessed using fluorescein angiography by means of a scanning laser ophthalmoscope (SLO). Visual function and visual field indices were evaluated during all drug treatment phases. Methods: Fourteen patients with newly diagnosed POAG (age 55 ± 7 years; 10 male, four female) were recruited for the study. At baseline examination, blood pressure, heart rate, intraocular pressure (IOP), SLO angiograms, and contrast sensitivity (CS) were analysed. Patients then ...
Naproxen and ibuprofen work in the body the same and have the same side effects. Bimatoprost Timolol 3ml combination ophthalmic solution is used for treating high.Frequently Asked Questions. If you experience these or other side effects, you should. (brimonidine tartrate/timolol maleate ophthalmic solution ...
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Efficiency, safety, and patient preference of switching from dorzolamide 1%/timolol 0.5% to brinzolamide 1%/timolol 0.5% while maintaining the prostaglandin F2α analog Yoshie Shimizu,1 Shunsuke Nakakura,1 Makiko Nishiyama,1 Hitoshi Tabuchi,1 Yoshiaki Kiuchi2 1Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, 2Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan Background: We investigated the efficiency, safety and patient preference of switching from dorzolamide 1%/timolol 0.5% to brinzolamide 1%/timolol 0.5% while maintaining the prostaglandin F2α analog.Methods: We initially enrolled 44 eyes from 44 primary open angle glaucoma patients, and a total of 42 patients completed the study. All patients were under treatment with various prostaglandin F2α analogs and dorzolamide 1%/timolol 0.5%. While maintaining the prostaglandin F2α analog, dorzolamide 1%/timolol 0.5% was switched to
HONG-JIAN ZHU, QINGHONG LIU, XIAO-LI DENG, YAN-XING GUAN, Efficacy of low-dose 90Sr-90Y therapy combined with topical application of 0.5% timolol maleate solution for the treatment of superficial infantile hemangiomas, Experimental and Therapeutic Medicine, 2015, 10, 3, ...
Latanoprost+Timolol 50 micrograms/ml + 5 mg/ml eye drops, solution - Summary of Product Characteristics (SmPC) by Martindale Pharma, an Ethypharm Group Company
Generic Cosopt is used to treat certain types of glaucoma and other causes of high pressure inside the eye. Dorzolamide reduces the amount of fluid in the eye, which decreases pressure inside the eye. Timolol is a beta-blocker that also reduces pressure inside the eye.. Generic Cosopt (Dorzolamide, Timolol 2% + 0.5% 5ml) $ 33.32 pill - Eye Care @ Canadian Pharmacy - Quality Medicines Online. Buy Canadian medicines Online from safe Canadian pharmacy. Order Quality cheap drugs Online, 100% Anonymous, Worldwide guaranteed shipping.
|p|Timolol Maleate is a topical medication that can be applied directly in the eye that effectively reduces internal pressure in the eye. It is used in the treatment of glaucoma to lower elevated eye pressure that could damage vision and, with other glauc
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Dorzolamide/Timolol eye drops are used for lowering pressure in the eye to normal levels, and a treatment for glaucoma in cats and dogs. Ships fast!
To the editor: Leier and colleagues (1) have recently reported on the cardiovascular effects of ophthalmic timolol, a beta-adrenergic blocker commonly used to treat chronic glaucoma. We report a case of respiratory arrest that occurred after a first dose of timolol.. A 62-year-old woman allergic to penicillin and aspirin had a 46-year history of extrinsic asthma with multiple exacerbations in relation to seasonal environmental conditions that were usually treated with albuterol aerosols. At age 26, she had retinal detachment of the right eye and subsequent amaurosis. A few days before the current hospitalization, the diagnosis of glaucoma was established and ...
To the best of our knowledge no previous studies compared Tafluprost and PF Timolol in terms of tear function and corneal layers morphology; just Chabi et al. compared their tolerability and safety resulting in a similar incidence of drug related adverse events, discontinuation attributable to them and tolerability [18].. Our data show that patients treated either with Tafluprost or PF Timolol dont differ in clinical signs and symptoms.. On the other hand the comparison with controls reveals significant differences in some corneal parameters analyzed by IVCM suggesting a side effect of the active compounds on the corneal layers after a long term therapy.. The IVCM data of our control group are comparable to those available in literature for IVCM of normal patients. We found significant differences between IVCM parameters of Tafluprost and control groups which confirm previous findings on the proinflammatory effect of PGA [19, 20]. In particular we observed an increase of the activation of ...
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A comparative study on safety and efficacy of travoprost and brimonidine/timolol fixed combination in patients of primary open angle glaucoma
Increased intraocular pressure (IOP) is a significant risk factor for the development of glaucoma. Timolol maleate is a beta-adrenergic receptor blocking agent and it is used for the treatment of glaucoma in order to reduce the elevated IOP that is characteristic of this eye disease. Systemic toxicity from topical timolol occurs more frequently than local toxicity and can affect the pulmonary, cardiac and central nervous systems. The objective of the present study, therefore, was to formulate multilamellar vesicles (MLVs) liposomal preparations of timolol maleate using their advantage of being less toxic compared with non-liposome-based drugs to be applied topically and to evaluate the in vivo performance of the prepared liposomes to extend the time of reduced IOP of glaucomatous rabbits eye measured using a standard Shiotz tonometer ...
Patients may need to take more than one eye drop product pursuant to multiple dosing regimens, as directed by his or her prescriber, in order for the active ingredients to remain effective throughout the day.. *For professional use only. ImprimisRx® Pharmacy specializes in customizing medications to meet unique patient and practitioner needs. ImprimisRx® dispenses only to individually identified patients with valid prescriptions. No compounded medication is reviewed by the FDA for safety or efficacy. ImprimisRx® does not compound copies of commercially available products. References available upon request.. Potential Ingredient Risks. Storage: Store under refrigeration, 2°C to 8°C (36°F to 46°F). Auxiliary Labeling: Store upright in original bottle, Protect from light, For professional use only.. Timolol Maleate. Possible Indications: Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Possible Adverse Effects: Ocular burning/stinging on ...
DuoTrav eye drops contain two active ingredients, travoprost and timolol maleate. These are both medicines that lower raised pressure within the eye. They work in different ways to produce a combined effect greater than either medicine produces on its own.
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As noted just previously, the current thresholds could permit allowing a person to divert approximately 25 pounds pounds of timolol maleate and 66 pounds of indacaterol annually, without far exceeding existing thresholds. For 2 days after getting timolol, its best to take lorcaserin. While drugs act like Sandoz travoprost / timolol pq are prescribed less frequently than in the past, emergency room visits for nonmedical drug use of timolol increased by removing approximately 6,000 betw
Dorzolamide/timolol is commonly prescribed for the treatment of glaucoma and intraocular hypertension. This eMedTV resource provides a detailed look at this prescription medicine, with information on dosing, side effects, safety concerns, and more.
There are no extenuating factors that affect the dose of dorzolamide/timolol a person is prescribed. This eMedTV resource explains why, describes when and how to use this eye drop, and offers a few guidelines that ensure a safe, effective treatment.
Brimonidine and timolol ophthalmic (eye) drops are used to treat increased pressure in the eye caused by glaucoma or a condition called hypertension of the eye. Both conditions are caused by high pressure in your eye and can lead to pain from pressure in your eye and then can eventually harm your vision. This medicine can help you keep your sight by reducing the pressure in your eye and stopping eye pain. ...
Combigan® solution is not for injection.. Do not use Combigan® eye drops if you are allergic to Timolol and Brimonidine.. Do not use Combigan® eye drops if you are allergic to any of the other ingredients comprised in Combigan® eye drops.. Do not stop using Combigan® eye drops suddenly, as abrupt discontinuation of Timolol eye drops can result in the development of myocardial ischemia, myocardial infarction, ventricular arrhythmias, or severe hypertension, particularly in patients with preexisting cardiovascular disease.. Combigan® eye drops are contraindicated in patients with cerebrovascular insufficiency (cerebrovascular disease) or stroke; acute bronchospasm, asthma, bronchitis, chronic obstructive pulmonary disease (COPD), emphysema, pulmonary disease; poorly controlled diabetes mellitus, particularly brittle diabetes; hyperthyroidism, thyroid disease, thyrotoxicosis; AV block, bradycardia, cardiogenic shock, heart failure, hypotension, pheochromocytoma, pulmonary edema, sick sinus ...
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Apo-Latanoprost-Timop: This is a combination product containing two different medications: latanoprost and timolol. Latanoprost belongs to a class of medications called prostaglandin analogs. It works to reduce the pressure in the eye by allowing fluid in the eye to flow better. Timolol belongs to a class of medications called beta-adrenergic receptor blockers (also known as beta-blockers). Latanoprost - timolol solution is available in an eye-drop form. It is used to reduce the pressure inside the eye for people with open-angle glaucoma or intraocular hypertension (increased pressure in the eye).
Read Effectiveness of levobetaxolol and timolol at blunting retinal ischaemia is related to their calcium and sodium blocking activities: relevance to glaucoma, Brain Research Bulletin on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Timolol is used to treat high blood pressure. It is also used to prevent migraine headaches, treat chest pain & improve chances of survival after heart attack.
Drug Information on Blocadren (timolol) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid.
Brand Name. Composition. Company. Packing. MRP Rs. eymol eye drops. Timolol maleate % w/v. solitaire. 5ml. N.A.. GLUCOMOL eye drops. Timolol. Timolol brands in India - Brimolol from Sun (Milmet), Careprost Plus from Sun (Avesta), Ganfort from Allergan Maleate, 5ml, Brimolol E- LOTION, Careprost Plus Timolol, Bimatoprost, -, Careprost Plus EYE-SOLN, Ophth Open-angle glaucoma; Ocular HTN As eye surgeon soln: Initial: Instill 1 department of Ophthalmic Timolol should not be predisposed alone for treatment of general-closure. Drug Price disliked in Indian Rupees (). Timolol Maleate, Benzalkonium ChIoride,Latanoprost, Ajanta Pharma Ltd, Bump, View Price. 6 Timolol Maleate, Dorzolamide, FDC Deliverable (Lumina), Drop, View Price. 10 Timol -OD Eye. During that cycle, which was annovulatory, I met with an RE who tapered me off of the clomid until maximum was done. Well, everythings back and he thinks to start me timolol maleate eye drops india on clomid (without the met) and he thinks me to start at ...
Objective: To demonstrate that the intraocular pressure (IOP)-reducing effect of latanoprost once daily is at least as good as that of timolol twice daily in patients with chronic angle-closure glaucoma (CACG). Design: Randomized, double-masked, multicenter 12-week study. Participants: In all, 137 patients with unilateral or bilateral CACG were treated with latanoprost, and 138 were treated with timolol. Methods: Patients received either latanoprost (9 PM) and a placebo (9 AM) or timolol (both 9 AM and 9 PM). Intraocular pressure was measured at 9 AM and 5 PM at baseline and weeks 2, 6, and 12. Main Outcome Measures: The difference between groups in daily IOP (average of 9 AM and 5 PM measures) reduction was the primary outcome. Secondary outcomes included differences between groups in IOP reductions at 9 AM and 5 PM, and in proportions of patients reaching specified daily IOP levels. Results: Using repeated measures (analysis of covariance: intent to treat), mean changes from baseline in daily ...
The present study was undertaken to compare efficacy and side effects of two drugs recently introduced for treatment of open angle glaucoma. The study was open labelled. The two eye drops have different viscosity and different administration regimens which made masking impractical.. The efficacy of latanoprost has previously been compared with 0.5% timolol in three 6 months studies.3-5 In two of these three studies the IOP reducing effect of latanoprost on diurnal IOP was significantly larger than the effect of timolol.3 5 The effect of dorzolamide on IOP, on the other hand, is less than that of timolol,8 which is explained by its weaker aqueous suppressive effect compared with timolol.9 Thus, one might expect that latanoprost should be the more effective drug of the two in terms of IOP reduction, an assumption which was confirmed in the present study. The effect of latanoprost on diurnal IOP was almost 3 mm Hg more than the effect of dorzolamide, 8.5 mm Hg compared with 5.6 mm Hg. Latanoprost ...
This study investigated the efficacy of brinzolamide/timolol fixed combination on intraocular pressure during 24 hours after uneventful phacoemulsification
Purpose: Topical timolol has been increasingly demonstrated to be an effective treatment for pyogenic granulomas (PG). The authors review the treatment outcomes of 17 patients with ocular PG treated with topical timolol.. Methods: Retrospective interventional study of 17 patients with ocular PGs treated with timolol 0.5% solution. Patient demographics, clinical features, treatment response, and recurrence were noted.. Results: Nine females and 8 males with a mean age of 23 years (range, 3-67 years) were included. Mean duration of disease prior to treatment was 3.81 months (range, 0.25-11 months). Etiologies included chalazia (12 cases, 71%), postsurgical (4, 24%) and trauma (1, 6%). Five patients (29%) had treatment with topical steroids prior to presentation. Fifteen patients (88%) had PG located on the palpebral conjunctiva and 2 (12%) involving the bulbar conjunctiva. Mean lesion size was 5.06 × 6.06 mm (range, 3-8 × 3-18 mm). Fifteen patients (88%) had complete lesion resolution with a ...
Timpilo information about active ingredients, pharmaceutical forms and doses by Merck, Timpilo indications, usages and related health products lists
Switched to DE-111 ophthalmic solution (one drop at a time, once daily, bilateral topical instillation) from Tafluprost ophthalmic solution 0.0015% (one drop at a time, once daily, bilateral topical instillation), Timolol ophthalmic solution 0.5% (one drop at a time, BID, bilateral topical instillation), or concomitant Tafluprost ophthalmic solution 0.0015% plus Timolol ophthalmic solution 0.5 ...
Glaucoma is one of the major disorders of the eye, causing increased pressure within the eyeball. It is of special concern to people older than 40 years of age. Although glaucoma is sometimes treated surgically, pressure in the eye can usually be reduced, and blindness prevented, through use of eyedrops. Frequently prescribed drugs for this purpose are timolol, betaxolol, dorzolamide, and latanoprost.. Timolol and betaxolol are beta-blocking drugs that work against glaucoma by decreasing the production of aqueous humor (fluid) in the eye. Unless they have a history of heart failure or asthma, most patients with glaucoma can use a beta blocker. Beta-blocking drugs account for most of the glaucoma medications sold. Dorzolamide is known as a carbonic anhydrate inhibitor, which works differently than the beta blockers to decrease the amount of fluid the eye produces. Sometimes, a beta blocker and a carbonic anhydrate inhibitor will be combined in a single drug product. Latanoprost is a prostaglandin ...
Study Eye: bimatoprost sustained-release (SR) Dose A administered on Day 1, Week 16, and Week 32; timolol vehicle administered once in the morning and once in the evening for up to 20 months. Non-Study Eye: sham administration on Day 1, Week 16, and Week 32; timolol administered once in the morning and once in the evening for up to 20 months ...
This combination medication is used to treat high pressure inside the eye due to glaucoma (open-angle type) or other eye diseases (e.
Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .. Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .. Do not interrupt or stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous .. ...
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Combigan (brimonidine tartrate, timolol maleate; Allergan) ophthalmic solution is now available in a new 15mL bottle size for a 90-day supply.
This trial investigated non-inferiority of preservative-free tafluprost (MK-2452) over preservative-free timolol maleate with respect to the diurnal intraocular
I have a 10 yo son. Bilateral Congenital cataracts, Lensectomy at 2 months of age, Aphakia, Glaucoma controlled with Timolol Maleate & Latanoprost. He wants to participate in a program for viewing Solar Eclipse on Aug 21st, from his elementary school. I am very very nervous with him doing so. They do provide Solar Eclipse glasses as certified/recommended by NASA. Any insights? Please guide. ...
Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or buy cialis - http://ci
Combigan containing Brimonidine and Timolol is used for treating ocular pressure and open-angle glaucoma. Buy Combigan online form our store.
We investigated her background factors in pediatric patients with diarrhea to examine the involvement of effective product in dispraise the event. Of the 25 patients about who merely received Zohydro er, all were free of headache within five days, and clothing all cultures were negative within 72 hr. The only significant and adverse reaction to Dorzolamide / timolol ophthalmic alone was a diarrhea that resolved after their discontinuation o
Longer-term stud- ies have shown that this drug has similar tolerability to betaxolol, timolol, and pilocarpine. Improving lopinavir genotype algorithm through phenotype correlations novel muta- tion quue and amprenavir cross-resistance. The key players who are obligated under GCP regulations are described below and will be referenced throughout this article Investigator. J Antimicrob Chemother 2002;50 1059в1063 73.
We present a mechanical shutter based on a bending piezo-actuator. The shutter features an active aperture of about 2 mm, allowing for full extinction and lossless transmission of a beam. Acoustic noise and mechanical vibrations produced are very low and the shutter is outstandingly long-lived; a test device has undergone 20 × 10{sup 6} cycles without breaking. A reflector makes the shutter capable of reliably interrupting a beam with at least 2 W of cw power at 780 nm. The shutter is well suited to create pulses as short as 16 ms, while pulse lengths down to 1 ms are possible. The rise and fall times are approximately 120 µs, with a delay of 2 ms. Jitter stays below 10 µs, while long-term drifts stay well below 500 µs. ...
Nov 15, 2016. Beta blockers, such as propranolol (Inderal) and timolol (Blocadren) are the oldest drugs for the prevention of migraine headaches.
Patients should be instructed to avoid allowing the tip of the dispensing container to contact the eye or surrounding structures. Patients should also be instructed that ocular solutions, if handled improperly, could become contaminated by common bacteria known to cause ocular infections. Serious damage to the eye and subsequent loss of vision may result from using contaminated solutions.. Patients should also be advised that if they have ocular surgery or develop an intercurrent ocular condition (e.g.,trauma or infection), they should immediately seek their physicianís advice concerning the continued use of the present multidose container. Patients should be instructed to invert the closed container and shake once before each use. It is not necessary to shake the container more than once. Patients requiring concomitant topical ophthalmic medications should be instructed to administer these at least 10 minutes before instilling Timolol GFS. Patients with bronchial asthma, a history of bronchial ...
5 mm thickness will pyelonepritis timolol differentially depending on the addition of a basic additive (disodium phos- phate). Complications of surgery can also keflex in pyelonephritis patient quality of life.
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Sigma-Aldrich offers abstracts and full-text articles by [J L Doignon, J M Grognet, J J Thébault, M Caplain, M H Capron, B Pelletier, M Wehrlen, M Istin].
Kaufman identified timolol as a possible therapeutic agent to treat glaucoma and with Thomas Zimmerman, conduct basic science ... Yale researcher Marvin Sears, observed that timolol, a beta-adrenergic agent, had an intraocular pressure lowering effect in ... PMID 14064628.CS1 maint: multiple names: authors list (link) Zimmerman TJ, Kaufman HE (1977). "Timolol. A Beta-Adrenergic ... co-developed timolol with Thomas Zimmerman, a new class of medications to treat glaucoma; corneal storage media for eye banks; ...
Topical beta blockers such as timolol. These can also be used in conjunction with oral beta blockers for greater effect, which ... "Oral propranolol combined with topical timolol for compound infantile hemangiomas: a retrospective study". Scientific Reports. ...
Topical timolol maleate, a nonselective beta blocker available in a gel-forming solution approved for the treatment of glaucoma ... 2013). "Topical timolol for small hemangiomas of infancy". Pediatr Dermatol. 30 (2): 245-9. doi:10.1111/j.1525-1470.2012.01723. ... 2012). "Timolol maleate 0.5% or 0.1% gel-forming solution for infantile hemangiomas: a retrospective multicenter cohort study ... Since that time, topical timolol maleate in addition to oral propranalol has become a common therapy for infantile hemangiomas ...
Timolol Niridazole Fenclozic acid Strosberg AM (August 1976). "The cardiovascular pharmacology and hemodynamic activity of ...
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
Atenolol, metoprolol (immediate release), propranolol (immediate release), timolol, carvedilol (after left ventricular ... Intermediate lipophilicity: metoprolol, bisoprolol, carvedilol, acebutolol, timolol, pindolol. *Low lipophilicity (also known ...
... typically timolol). Studies have shown bimatoprost to be more effective than timolol in reduction of intraocular pressure (IOP ... Bimatoprost does not negatively interact with timolol eye drops. Bimatoprost is a structural analog of prostaglandin F2α (PGF2α ...
"Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol ... It is also available as the combination dorzolamide/timolol. Common side effects include eye discomfort, eye redness, taste ...
Examples beta blockers are atenolol, metoprolol, nadolol, pindolol, propranolol, and timolol. Metoprolol is used to treat ...
Nonsteroidal anti-inflammatory drugs (NSAIDs) can either reduce or increase the effect of tafluprost.[1] Timolol eye drops, a ...
All β-blockers used systemically are delivered as racemate, except for timolol. Three different types of β-adrenergic receptors ...
Timolol, Levobunolol, and Betaxolol are common beta blockers prescribed to treat glaucoma. Alpha-adrenergic agonists work by ...
Limited basic and clinical evidence suggest that topical beta-blockers, such as timolol, may induce regression of localized ... topical timolol gel". Journal of the American Academy of Dermatology. 76 (1): 153-155. doi:10.1016/j.jaad.2016.08.041. PMID ...
Mori M, Sakurai M, Araie M (1993). "[Topical timolol and blood-aqueous barrier permeability to protein in human eyes]". Nippon ...
It is also the active ingredient of brimonidine/timolol along with timolol maleate. A 2017 Cochrane review found insufficient ...
The combination of brinzolamide with timolol is marketed under the trade name Azarga.[citation needed] Some diuretics inhibit ...
Herbette LG, Katz AM, Sturtevant JM (1983). "Comparisons of the interaction of propranolol and timolol with model and ...
"Carbopol/Chitosan Based pH Triggered In Situ Gelling System for Ocular Delivery of Timolol Maleate". Sci Pharm. 78 (4): 959-76 ...
Allergies are rare, but seem to be more common than under the related drug timolol. If the substance reaches the nasal mucosa ... "Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface". Cornea. 22 (8): 709-15. doi ...
... was more effective than timolol 0.5% twice daily in 3 of 4 large (n = 163 to 267) randomised, double-blind trials. ... Meta-analysis suggests that latanoprost is more effective than timolol in lowering intraocular pressure (IOP). However, it ... 2000). "Comparison of the intraocular pressure-lowering effect of latanoprost and timolol in patients with chronic angle ... 8.2 and 8.8 mm Hg vs 5.2 and 5.7 mm Hg for latanoprost vs timolol at 12 and 2 weeks, respectively). Listed from most to least ...
S01ED01 Timolol. S01ED02 Betaxolol. S01ED03 Levobunolol. S01ED04 Metipranolol. S01ED05 Carteolol. S01ED06 Befunolol. S01ED51 ... Timolol, combinations. S01ED52 Betaxolol, combinations. S01ED54 Metipranolol, combinations. S01ED55 Carteolol, combinations. ...
Dorzolamide/timolol combination versus concomitant administration of brimonidine and timolol: six-month comparison of efficacy ... anhydrase inhibitors Moderate-to-severe chronic kidney disease or liver disease The combination of brinzolamide with timolol is ...
The principal medication known to affect the retina are:- latanoprost, epinephrine, rosiglitazone, timolol and ...
Some drugs that have been successfully loaded via this method are: timolol, norfloxacin, ketotifen, polyvinlypyrrolidone, and ...
The beta blocker Timolol is also effective for migraine prevention and in reducing migraine attack frequency and severity. ...
The US Headache Consortium lists five drugs as having medium to high efficacy: amitriptyline, divalproex, timolol, propranolol ...
The medications within the eyedrops can include beta blockers (such as levobunolol or timolol) which slow the production of the ...
... has been shown clinically to reduce the clearance of mirtazapine, imipramine, timolol, nebivolol, sparteine, ...
Timolol: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Timolol comes as a tablet to take by mouth. It is usually taken one or two times a day. To help you remember to take timolol, ... Timolol helps control your condition but will not cure it. Continue to take timolol even if you feel well. Do not stop taking ... Before taking timolol,. *tell your doctor and pharmacist if you are allergic to timolol, any other medications, or any of the ...
Timolol. Sinus bradycardia and atrioventricular block in an elderly patient: case report ... Walia HS, Walia SS, Emanuel ME.Sick sinus syndrome associated with topical timolol maleate instillation. Journal of ... Timolol. React. Wkly. 1425, 35 (2012). https://doi.org/10.2165/00128415-201214250-00122 ...
Timolol Ophthalmic: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Timolol eye drops and gel-forming solution control glaucoma but do not cure it. Continue to use timolol even if you feel well. ... Before using timolol eye drops or gel-forming solution,. *tell your doctor and pharmacist if you are allergic to timolol, beta ... Use timolol exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
... timolol and latanoprost timolol and travoprost Timolol is marketed under many trade names worldwide. Timolol eye drops are ... For ophthalmic use, timolol is also available combined: with carbonic anhydrase inhibitors: timolol and brinzolamide timolol ... Timolol is a non-selective beta blocker. g Timolol was patented in 1968, and came into medical use in 1978. It is on the World ... "Timolol". Drugs.com. Archived from the original on 7 March 2016. Retrieved 28 December 2016. "Timolol eent". The American ...
A list of US medications equivalent to Timolol OSL is available on the Drugs.com website. ... Timolol OSL is a medicine available in a number of countries worldwide. ... Ingredient matches for Timolol OSL. Timolol. Timolol is reported as an ingredient of Timolol OSL in the following countries:. * ... Timolol OSL. Timolol OSL may be available in the countries listed below. ...
... travoprost and timolol maleate. These are both medicines that lower raised pressure within the eye. They work in different ways ... DuoTrav eye drops (travoprost, timolol). DuoTrav eye drops contain two active ingredients, travoprost and timolol maleate. ... The timolol in these eye drops may enhance the effects of the following medicines taken by mouth, which may result in low blood ... Timolol is a type of medicine called a beta-blocker. These medicines block beta-receptors in various parts of the body. ...
... bimatoprost and timolol maleate. These are both medicines that decrease raised pressure within the eye. They work in different ... Ganfort eye drops (bimatoprost, timolol). Ganfort eye drops contain two active ingredients, bimatoprost and timolol maleate. ... The timolol in these eye drops may enhance the effects of the following medicines taken by mouth, which may result in low blood ... Timolol can be absorbed into the bloodstream after being applied into the eye and may mask the symptoms of low blood sugar, ...
... brinzolamide/timolol) is a twice-daily eyedrops suspension comprising the carbonic anhydrase-II inhibitor brinzolamide and the ... Brinzolamide 1%/timolol 0.5% fixed combination (brinzolamide/timolol) is a twice-daily eyedrops suspension comprising the ... The safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with ... Moreover, a significantly greater number of patients expressed a preference for brinzolamide/timolol over dorzolamide/timolol. ...
DORZOLAMIDE-TIMOLOL. DORZOLAMIDE HCL/TIMOLOL MALEAT. The combination of dorzolamide and timolol is used to treat eye conditions ... Top prescribers for DORZOLAMIDE-TIMOLOL. 1 2 3 4 5 … Next › Last » ...
If you have an allergy to brinzolamide, timolol, or any other part of this drug. ...
Find patient medical information for Timolol-Hydrochlorothiazide Oral on WebMD including its uses, side effects and safety, ... What should I know regarding pregnancy, nursing and administering Timolol-Hydrochlorothiazide Tablet to children or the elderly ...
Information about this timolol-and-hydrochlorothiazide-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal ... Timolol is a beta-blocker. It works by affecting the response to some nerve impulses in certain parts of the body, like the ... Timolol and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to ... Appropriate studies have not been performed on the relationship of age to the effects of timolol and hydrochlorothiazide ...
Brimonidine and timolol ophthalmic (eye) drops are used to treat increased pressure in the eye caused by glaucoma or a ... Information about this brimonidine-and-timolol-ophthalmic-route. Pregnancy Category. Explanation. All Trimesters. C. Animal ... performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of brimonidine and timolol ... performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of brimonidine and timolol ...
Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the ... Act Latanoprost/timolol. Timolol (5 mg) + Latanoprost (50 mcg). Solution. Ophthalmic. Actavis Pharma Company. 2015-09-29. Not ... Timolol hemihydrate. 817W3C6175. 91524-16-2. TWBNMYSKRDRHAT-RCWTXCDDSA-N. Timolol maleate. P8Y54F701R. 26921-17-5. ... Similar to propranolol and nadolol, timolol is a non-selective, beta-adrenergic receptor antagonist. Timolol does not have ...
Timolol is a beta-blocker that also reduces pressure inside the eye. Brimonidine and timolol ophthalmic (for the eyes) is used ... How should I take brimonidine and timolol ophthalmic?. How should I take brimonidine and timolol ophthalmic?. Follow all ... What should I avoid while taking brimonidine and timolol ophthalmic?. What should I avoid while taking brimonidine and timolol ... What is brimonidine and timolol ophthalmic?. What is brimonidine and timolol ophthalmic?. Brimonidine reduces the amount of ...
Timolol ophthalmic is a beta-blocker that also reduces pressure inside the eye. Dorzolamide and timolol ophthalmic (for the ... What should I avoid while using dorzolamide and timolol ophthalmic?. Dorzolamide and timolol ophthalmic can cause blurred ... What other drugs will affect dorzolamide and timolol ophthalmic?. Other drugs may interact with dorzolamide and timolol ... Dorzolamide and timolol ophthalmic (for the eyes) is a combination medicine used to treat certain types of glaucoma and other ...
Timolol Maleate (UNII: P8Y54F701R) (Timolol Anhydrous - UNII:5JKY92S7BR) Timolol Anhydrous. 5 mg in 1 mL. ... dorzolamide HCl 2 % / timolol maleate 0.5 % Ophthalmic Solution. PSN. 2. 1923432. dorzolamide 20 MG/ML / timolol 5 MG/ML ... Timolol Maleate In a study of plasma drug concentrations in six subjects, the systemic exposure to timolol was determined ... Timolol Maleate is stable at room temperature.. Dorzolamide HCl/Timolol Maleate Ophthalmic Solution is supplied as a sterile, ...
Timolol ophthalmic (for the eyes) is used to treat open-angle glaucoma and other causes of high pressure inside the eye. ... Timolol ophthalmic may also be used for purposes not listed in this medication guide. ... Timolol is a beta-blocker that also reduces pressure inside the eye. ... What should I avoid while using timolol ophthalmic?. Timolol ophthalmic can cause blurred vision. Be careful if you drive or do ...
Timolol is used to treat high blood pressure. It is also used to prevent migraine headaches, treat chest pain & improve chances ... Timolol Warnings. Timolol contains a black box warning because it may cause chest pain or a heart attack if you stop taking it ... Pregnancy and Timolol. Its not known whether timolol could harm an unborn baby if taken during pregnancy, but it has been ... Timolol and Alcohol. Alcohol can worsen certain side effects of timolol.. Talk to your doctor before drinking alcoholic ...
Replenish Depleted Nutrients none Reduce Side Effects Coenzyme Q10 In a group of 16 glaucoma patients treated with a timolol ... In a group of 16 glaucoma patients treated with a timolol eye preparation, six weeks of oral coenzyme Q10 (90 mg per day) was ... reported to reduce timolol-induced cardiovascular side effects without affecting intraocular pressure treatment. ...
Drug: Timolol Apply timolol on half of the participants face for 8 weeks. Then treat both sides of face for 8 weeks. ... Timolol for the Treatment of Acne and Rosacea. The safety and scientific validity of this study is the responsibility of the ... Timolol for the Treatment of Acne and Rosacea Brief Summary This research is being done to determine the safety and ... Timolol is approved by the Food and Drug Administration (FDA) for the treatment of glaucoma. In dermatology, it has been used ...
The treatment period was 3 weeks and during this period timolol + brimonidine or timolol + placebo were applied topically twice ... The timolol + placebo combination had no clinically significant IOP-lowering effect (P , 0.05). No clinically significant side ... Conclusions This study showed that the combination of topically applied brimonidine and timolol cause a marked and sustained ... on therapy receiving timolol maleate 0.5% twice daily, with IOP greater than or equal to 22 mmHg in one eye. ...
Combigan Ophthalmic Solution 10ml (brimonidine tartrate/timolol maleate) Coupon. Timolol maleate and Dorzolamide HCl ophthalmic ... If you have eye surgery, injury or infection consult your eye doctor about continued use of your current timolol bottle. This ...
It may be used when a patient is sensitive to the preservative in TIMOPTIC (timolol maleate ophthalmic solution), benzalkonium ... In an epidemiologic survey, patients who were switched to a preservative-free timolol experienced fewer ocular symptoms, such ... For patients who are sensitive to the preservative in TIMOPTIC (timolol maleate ophthalmic solution), benzalkonium chloride ( ... TIMOPTIC 0.25% AND 0.5% (TIMOLOL MALEATE OPHTHALMIC SOLUTION) in OCUDOSE : Additional information ...
Timolol is also used for the prevention of migraine headaches but is not useful for treatment of a headache once it has started ... Timolol belongs to the class of medications called beta-blockers. It is used for the treatment of high blood pressure. It is ... 01947796 TEVA-TIMOLOL 5MG TABLET. 01947818 TEVA-TIMOLOL 10MG TABLET. 01947826 TEVA-TIMOLOL 20MG TABLET. ... Timolol blocks the action of chemicals that increase the hearts workload. Beta-blockers such as timolol lower the heart rate, ...
Timolol eye drops are used to treat glaucoma and increased pressure in the eye. ... Dom-Timolol: This medication belongs to the family of medications called beta-blockers. ... 02238770 DOM-TIMOLOL 0.25% OPHTHALMIC LIQUID. 02238771 DOM-TIMOLOL 0.5% OPHTHALMIC LIQUID. ... The usual starting dose is one drop of timolol 0.25% solution in the affected eye(s) twice daily. If the response to the drops ...
... timolol) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid. ... If you are taking timolol to prevent migraine headaches: It may take 6 to 8 weeks of daily use before timolol is fully ... Timolol is also used to prevent migraine headaches.. Timolol may also be used for purposes not listed in this medication guide. ... Timolol is used to treat hypertension (high blood pressure). Timolol is sometimes given with other blood pressure medication. ...
  • These highlights do not include all the information needed to use Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution safely and effectively. (nih.gov)
  • See full prescribing information for Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution. (nih.gov)
  • Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution is a carbonic anhydrase inhibitor with a beta-adrenergic receptor blocking agent indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. (nih.gov)
  • The IOP-lowering of Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution twice daily was slightly less than that seen with the concomitant administration of 0.5% timolol twice daily, and 2% dorzolamide three times daily. (nih.gov)
  • The dose is one drop of Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution in the affected eye(s) two times daily. (nih.gov)
  • Potential additive effect of oral carbonic anhydrase inhibitor with Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution. (nih.gov)
  • Dorzolamide HCl/Timolol Maleate Ophthalmic Solution is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time). (nih.gov)
  • For patients who are sensitive to the preservative in TIMOPTIC (timolol maleate ophthalmic solution), benzalkonium chloride (BAK), TIMOPTIC in OCUDOSE is a preservative-free eye drop for reducing intraocular pressure. (bausch.com)
  • It may be used when a patient is sensitive to the preservative in TIMOPTIC (timolol maleate ophthalmic solution), benzalkonium chloride, or when use of a preservative-free topical medication is advisable. (bausch.com)
  • Teva discontinued dorzolamide and timolol ophthalmic solution in April 2018. (ashp.org)
  • Bausch Health had dorzolamide and timolol ophthalmic solution on shortage due to manufacturing delays. (ashp.org)
  • Sandoz has dorzolamide/timolol 2%/0.5% ophthalmic solution in 10 mL bottles on back order and the company cannot estimate a release date. (ashp.org)
  • Patient with certain types of high pressure inside eyes often looking for Cheap Dorzolamide with Timolol ophthalmic solution online as Cosopt generic from Merck pharmaceutical company. (drugsonline.xyz)
  • People diagnosed with ocular hypertension have to know Where to buy cheap Combigan generic containing Brimonidine Tartrate 0.2% and Timolol Maleate 0.5% ophthalmic solution. (drugsonline.xyz)
  • Long-term experience with timolol ophthalmic solution in patients with open-angle glaucoma. (harvard.edu)
  • Ophthalmic timolol is used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision. (medlineplus.gov)
  • Timolol eye drops and gel-forming solution control glaucoma but do not cure it. (medlineplus.gov)
  • A Cochrane review compared the effect of timolol versus brimonidine in slowing the progression of open angle glaucoma in adults but found insufficient evidence to come to conclusions. (wikipedia.org)
  • Brinzolamide/timolol produced clinically relevant reductions in mean intraocular pressure (IOP) from baseline and was more effective than brinzolamide or timolol monotherapy in lowering IOP in a 6-month, randomized, phase III trial in patients with open-angle glaucoma or ocular hypertension (n = 523). (springer.com)
  • Brimonidine and timolol ophthalmic (eye) drops are used to treat increased pressure in the eye caused by glaucoma or a condition called hypertension of the eye. (mayoclinic.org)
  • Brimonidine and timolol ophthalmic (for the eyes) is used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). (cigna.com)
  • Dorzolamide and timolol ophthalmic (for the eyes) is a combination medicine used to treat certain types of glaucoma and other causes of high pressure inside the eye. (cigna.com)
  • Timolol also comes in an ophthalmic formulation to treat glaucoma (an eye condition). (everydayhealth.com)
  • In a group of 16 glaucoma patients treated with a timolol eye preparation, six weeks of oral coenzyme Q10 (90 mg per day) was reported to reduce timolol-induced cardiovascular side effects without affecting intraocular pressure treatment. (adventisthealthcare.com)
  • Timolol is approved by the Food and Drug Administration (FDA) for the treatment of glaucoma. (clinicaltrials.gov)
  • Purpose To evaluate the additive ocular hypotensive effect of the combination of brimonidine and timolol on intraocular pressure (IOP) reduction in patients with glaucoma. (nature.com)
  • Methods This was a prospective, randomized, double-masked, crossover study in 20 patients with primary open angle glaucoma (POAG) on therapy receiving timolol maleate 0.5% twice daily, with IOP greater than or equal to 22 mmHg in one eye. (nature.com)
  • All patients met the following criteria: age older than 22 years, a clinical diagnosis of primary open-angle glaucoma, patients already receiving timolol twice daily, corrected visual acuity of 20/80 or better in each eye. (nature.com)
  • Patients were excluded from the study for any of the following reasons: active ocular infection and ocular disease other than glaucoma (blepharitis or cataract e.t), use of systemic and topical medications except timolol, prior treatment with any ocular surgery or laser therapy, contraindications to the use of alpha-adrenoreceptor agonist, female patients who were pregnant, lactating, or unstable cardiopulmonary disease. (nature.com)
  • The purpose of this study is to examine the ocular hypotensive effect of Bimatoprost and the potential additional effect of the Bimatoprost/Timolol fixed combination in eyes with ocular hypertension, primary open angle glaucoma or exfoliation glaucoma. (clinicaltrials.gov)
  • Efficacy Of The Bimatoprost/Timolol Fixed Combination In Patients Treated With Bimatoprost for Primary Open Angle Glaucoma, Exfoliation Glaucoma or Ocular Hypertension. (clinicaltrials.gov)
  • Timolol treats open-angle glaucoma and secondary glaucoma. (petcarerx.com)
  • To the editor: Leier and colleagues (1) have recently reported on the cardiovascular effects of ophthalmic timolol, a beta-adrenergic blocker commonly used to treat chronic glaucoma. (annals.org)
  • Additive effect of epinephrine to timolol therapy in primary open angle glaucoma. (biomedsearch.com)
  • Timolol Maleate is the most commonly prescribed medication for veterinary use in the treatment of glaucoma in animals. (petcarerx.com)
  • Twenty-eight patients (28 eyes) with primary open-angle glaucoma, who had used tafluprost and timolol gel for at least 3 months with good adherence, were enrolled. (dovepress.com)
  • TIMOLOL (TYE moe lole) is used in the eye to treat open-angle glaucoma and high pressure in the eye. (brighamandwomens.org)
  • The FDA has approved timolol maleate to treat glaucoma in adults, but the FDA has not approved timolol maleate to treat hemangiomas in children. (clinicaltrials.gov)
  • Effect of timolol with and without preservative on the basal tear turnover in glaucoma. (bmj.com)
  • Oftan Timolol ® / Optimol ® is a solution of Timolol maleate 0.25% and 0.5% indicated for the treatment of several types of glaucoma to lower intraocular pressure. (santen.eu)
  • To evaluate the 24 h efficacy and safety of the travoprost/timolol maleate fixed combination (TTFC) versus travoprost when both are dosed in the evening in primary open-angle glaucoma patients. (bmj.com)
  • Glaucoma causes pressure to build up in your pet's eye -- Dorzolamide Timolol Eye Drops help reverse that process. (vetrxdirect.com)
  • Dorzolamide Timolol Eye Drops can be used to treat a diseased eye while protecting the healthy eye from the glaucoma. (vetrxdirect.com)
  • Effects of dorzolamide 2% added to timolol maleate 0.5% on intraocular pressure, retrobulbar blood flow, and the progression of visual field damage in patients with primary open-angle glaucoma: a single-center, 4-year, open-label study. (druglib.com)
  • OBJECTIVE: This study assessed the long-term effects of dorzolamide 2% BID added to timolol maleate 0.5% BID on intraocular pressure (IOP), retrobulbar blood flow, and the progression of visual field damage in patients with primary open-angle glaucoma. (druglib.com)
  • CONCLUSIONS: In this 4-year, open-label study in patients with primary open-angle glaucoma, dorzolamide 2% BID added to timolol 0.5% BID was associated with a significant reduction in IOP and significant increases in retrobulbar hemodynamic parameters in both the ophthalmic and short posterior ciliary arteries. (druglib.com)
  • Based on these data we conclude that β-blockers may be able to blunt ganglion cell death in glaucoma, and that levobetaxolol may be a more effective neuroprotectant than timolol because of its greater capacity to block sodium and calcium influx. (deepdyve.com)
  • INTRODUCTION AND PURPOSE: Bimatoprost and the fixed combination of latanoprost with timolol maleate are 2 medications widely used to treat glaucoma and ocular hypertension (OHT). (druglib.com)
  • Aim: Aim of the study was to evaluate the safety and efficacy of the once daily fixed combination timolol 0.5%/ travoprost 0.004% versus twice daily timolol 0.5% associated with once daily travoprost 0.004% in patients with primary open angle glaucoma or ocular hypertension. (minervamedica.it)
  • Conclusion: Timolol 0.5%/travoprost 0.004% fixed combination was well-tolerated and produced significant additional IOP reduction when switched from other anti-glaucoma drugs in patients with primary open angle glaucoma or ocular hypertension. (minervamedica.it)
  • When the other anti-glaucoma drugs are withdrawn the both preparations should be applied during 1 day (under the intraocular pressure control), than only timolol is to be applied. (belmedpreparaty.com)
  • The aim of this prospective crossover study was to evaluate the non-inferiority of PRO-122 (a preservative-free fixed combination) compared with 0.5% timolol + 0.2% brimonidine + 2.0% dorzolamide fixed combination (KOF) by evaluating its efficacy, tolerability and safety in subjects with controlled primary open-angle glaucoma (POAG) previously treated with KOF for at least 2 months. (springermedizin.de)
  • Efficacy and safety of benzalkonium chloride-free fixed combination of latanosprot and timolol in patients with open-angle glaucoma or ocular hypertension. (springermedizin.de)
  • Kaufman identified timolol as a possible therapeutic agent to treat glaucoma and with Thomas Zimmerman, conduct basic science and clinical trials with timolol, at the University of Florida. (wikipedia.org)
  • The usual starting dose is one drop of timolol 0.25% solution in the affected eye(s) twice daily. (medbroadcast.com)
  • Timolol eye drops are usuallyinstilled once or twice a day, at evenly spaced intervals, until pressure in the eye is controlled (about 4 weeks). (medlineplus.gov)
  • if you are using another topical eye medication, instill it at least 10 minutes before or after you instill timolol eye drops or gel-forming solution. (medlineplus.gov)
  • if you have eye surgery, an eye injury, or develop an eye infection while using timolol eye drops or gel-forming solution, ask your doctor if you can continue using the same container of timolol. (medlineplus.gov)
  • if you wear soft contact lenses, remove them before instilling timolol eye drops or gel-forming solution, and wait until 15 minutes after using timolol to put them back in. (medlineplus.gov)
  • Timolol is a beta blocker medication used either by mouth or as eye drops. (wikipedia.org)
  • Timolol eye drops are marketed under the brand name Istalol among others. (wikipedia.org)
  • DuoTrav eye drops contain two active ingredients, travoprost and timolol maleate. (netdoctor.co.uk)
  • Ganfort eye drops contain two active ingredients, bimatoprost and timolol maleate. (netdoctor.co.uk)
  • Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of brimonidine and timolol eye drops in children 2 years of age and older. (mayoclinic.org)
  • If the response to the drops is not adequate, your doctor may change the dose to one drop of timolol 0.5% solution in each of the affected eye twice daily. (medbroadcast.com)
  • Please read this leaflet carefully before you start using APO-Latanoprost/Timolol Eye drops. (nps.org.au)
  • This leaflet answers some common questions about latanoprost/timolol eye drops. (nps.org.au)
  • The name of your medicine is APO-Latanoprost/Timolol eye drops. (nps.org.au)
  • Timolol Maleate is a topical drug that can be obtained by prescription and is available as suspension eye drops. (petcarerx.com)
  • The active ingredient in these eye drops is timolol maleate. (canadapharmacy.com)
  • No studies have been conducted with Brinzolamide/Timolol or with timolol 5 mg/ml eye drops in patients with hepatic or renal impairment. (medicines.org.uk)
  • Latanoprost / Timolol 50 micrograms / ml + 5 mg / ml Eye Drops, Solution should be used with caution, in patients with mild/moderate chronic obstructive pulmonary disease (COPD) and only if the potential benefit outweighs the potential risk. (medicines.org.uk)
  • Prescription Dorzolamide Timolol Eye Drops lower pressure in the eye by combining two effective ingredients into one solution. (vetrxdirect.com)
  • Dorzolamide/ Timolol Eye Drops are sold as an FDA approved generic drug. (vetrxdirect.com)
  • The recommended adult dose of dorzolamide - timolol eye drops is one drop in the affected eye(s) twice daily. (canoe.com)
  • Dorzolamide - timolol eye drops should be used at least 10 minutes before or after other eye drops that are being used. (canoe.com)
  • Timolol is available as a generic medication. (wikipedia.org)
  • The medication should not be taken by individuals with: An allergy to timolol or any other beta-blockers Asthma or severe chronic obstructive bronchitis A slow heart rate (bradycardia), or a heart block Heart failure The most serious possible side effects include cardiac arrhythmias and severe bronchospasms. (wikipedia.org)
  • Brimonidine and timolol ophthalmic may also be used for purposes not listed in this medication guide. (cigna.com)
  • Timolol is sometimes given with other blood pressure medication. (emedicinehealth.com)
  • Although the risk of serious side effects is low when dorzolamide and timolol is used in the eyes, you should be aware of side effects that can occur if the medication is absorbed into your bloodstream. (emedicinehealth.com)
  • Timolol is a type of medication, called a beta-blocker, that also reduces pressure. (vetrxdirect.com)
  • This is a combination medication that contains two ingredients: dorzolamide and timolol. (canoe.com)
  • Patients who used timolol were more likely to discontinue medication in the first 4 weeks, whereas lacidipine users discontinued where it in shepherding the following weeks. (alpharettaband.com)
  • Walia HS, Walia SS, Emanuel ME.Sick sinus syndrome associated with topical timolol maleate instillation. (springer.com)
  • For ophthalmic use, timolol is also available combined: with carbonic anhydrase inhibitors: timolol and brinzolamide timolol and dorzolamide with α2 agonists: timolol and brimonidine with prostaglandin analogs: timolol and latanoprost timolol and travoprost Timolol is marketed under many trade names worldwide. (wikipedia.org)
  • To assess the safety and efficacy of changing to the travoprost/timolol fixed combination (TTFC) from other mono- or adjunctive therapies. (dovepress.com)
  • After three months of treatment with fixed combination (timolol 0.5%/ travoprost 0.004%) the IOP reduced was statistically significant. (minervamedica.it)
  • Efficacy of timolol in lowering IOP during the sleep period may be limited. (wikipedia.org)
  • The IOP-lowering efficacy of brinzolamide/timolol was maintained for up to 12 months, and was no less effective than dorzolamide 2%/timolol 0.5% solution (dorzolamide/timolol) in a randomized, phase III, noninferiority trial (n = 437). (springer.com)
  • To evaluate the efficacy and safety of tafluprost/timolol fixed combination (TTFC). (dovepress.com)
  • Specifically the efficacy, side effects and outcome of PDL and timolol will be compared with no treatment, the present standard of care for early stage hemangiomas. (clinicaltrials.gov)
  • The safety and efficacy of Brinzolamide/Timolol in children and adolescents aged 0 to 18 years have not yet been established. (medicines.org.uk)
  • Further studies with large sample sizes should be taken to support the superior efficacy of latanoprost/timolol, as well as to better assess its profile of side effects. (druglib.com)
  • The sample was analyzed using methanol: 1-octane sulphonic acid buffer, in the ratio of 55:45 as a mobile phase at a flow rate of 1.0 ml/min and detection with UV/Visible detector at two fixed wavelength (254.0 nm for Dorzolamide HCl and 295.0 nm for Timolol Maleate). (ozon.ru)
  • Severe respiratory reactions and cardiac reactions, including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure, have been reported following systemic or ophthalmic administration of timolol maleate. (bausch.com)
  • Cardiac reactions, and rarely, death in association with cardiac failures have been reported following administration of timolol. (medicines.org.uk)
  • Concomitant administration of timolol with verapamil Verapamil , may cause asystole. (vetstream.com)
  • tell your doctor and pharmacist if you are allergic to timolol, beta blockers, or any other drugs. (medlineplus.gov)
  • What other drugs will affect timolol (Blocadren)? (emedicinehealth.com)
  • A kinetic model for the prediction of the plasma concentration of topically administered drugs was described for estradiol, hyoscine, and timolol. (cdc.gov)
  • The predictive equations were applied to estradiol, hyoscine, and timolol using physiochemical and pharmacokinetic data obtained from the published literature, the surface areas of the transdermal devices used as the delivery system, and the in-vitro release characteristics of the drugs in either the patch adhesive or the topical vehicle used for administration of the therapeutic agent. (cdc.gov)
  • Above there is a review of a few trusted and qualitative online drugstores and pharmacies where you can buy timolol or order cheap Timoptic (Timolol Maleate) online, get discount coupon, compare prices for eye care products, antiglaucoma drugs, ophthalmological medications, beta-adrenergic blocking agents, and many other medicines at a low prices to choose the most acceptable offer for you. (drugsonline.xyz)
  • A rapid, simple, accurate and economic High Performance Liquid Chromatographic analysis method has been developed for simultaneous estimation of Dorzolamide Hydrochloride (HCl) and Timolol Maleate in eye drop dosage forms is highly desirable to support formulation screening and quality control. (ozon.ru)
  • The present book describes the simultaneous estimation method of Dorzolamide Hydrochloride and Timolol Maleate in eye drop dosage form. (ozon.ru)
  • Each mL of sterile, isotonic, buffered, slightly viscous, aqueous solution contains 20 mg of dorzolamide (as 22.3 mg of dorzolamide hydrochloride) and 5 mg of timolol (as 6.83 mg of timolol maleate). (canoe.com)
  • We propose a prospective, single blinded, randomized study of pulsed dye laser (PDL) and topical beta-blocker solution (timolol maleate ophthalmic gel forming solution) in the treatment of very early hemangiomas. (clinicaltrials.gov)
  • For this reason we have performed this clinical placebo-controlled study of the additive effect of brimonidine tartrate 0.2% and timolol maleate 0.5% in a short-term period. (nature.com)
  • Equivalent doses of propranolol and timolol were given parenterally for 8 weeks. (clinsci.org)
  • 3. Growth rate of animals given propranolol intraperitoneally was significantly less than controls, whereas animals given propranolol subcutaneously or timolol intraperitoneally grew normally. (clinsci.org)
  • Timolol ophthalmic may contain a preservative that can discolor soft contact lenses. (uwhealth.org)
  • In an epidemiologic survey, patients who were switched to a preservative-free timolol experienced fewer ocular symptoms, such as pain and discomfort upon instillation. (bausch.com)
  • Ophthalmic timolol comes as a solution (liquid) and an extended-release (long-acting) gel-forming solution (liquid that thickens to a gel when instilled in the eye). (medlineplus.gov)
  • Timolol gel-forming solution is usually instilled once a day. (medlineplus.gov)
  • you should know that your vision may be blurred during your treatment with timolol gel-forming solution. (medlineplus.gov)
  • Solution containing 20 mg/mL dorzolamide and 5 mg/mL timolol. (nih.gov)
  • Latanoprost - timolol solution is available in an eye-drop form. (medbroadcast.com)
  • Each 1 mL of sterile, isotonic, buffered, clear, colourless aqueous solution contains 50 µg of latanoprost and 5 mg of timolol. (medbroadcast.com)
  • As she was complaining of cosmetic blemish, she was started on topical timolol maleate 0.5% gel solution two times per day after ruling out cardiac and pulmonary diseases by the cardiology and pulmonary medicine departments, respectively. (bmj.com)
  • One generic solution that works the same as Cosopt contains Dorzolamide, a carbonic anhydrase inhibitor, and Timolol Maleate, a beta-blocker. (kiwidrug.com)
  • tell your doctor and pharmacist if you are allergic to timolol, any other medications, or any of the ingredients in timolol tablets. (medlineplus.gov)
  • It contains the active ingredients latanoprost and timolol (as maleate). (nps.org.au)
  • Timolol is in a class of medications called beta blockers. (medlineplus.gov)
  • Does Timolol-Hydrochlorothiazide Tablet interact with other medications? (webmd.com)
  • Timolol belongs to the class of medications called beta-blockers . (medbroadcast.com)
  • Timolol is often used along with other medications to treat high blood pressure. (medbroadcast.com)
  • This is a combination product containing two different medications: latanoprost and timolol. (medbroadcast.com)
  • Comparison of in vitro trans corneal diffusion of timolol under static and simulated tear flow conditions to compare results from published animal pharmacokinetic data.It is recognized that the topical delivery of medications to the eye is challenged by the flow of tears removing formulation from the pre corneal area. (arvojournals.org)
  • This generic Timolol RX card works for nearly all FDA-approved prescription medications, including diabetic test strips, at nearly all pharmacies in the U.S. for instant discounts, just like a generic Timolol coupon. (pscard.com)
  • I have been using topical timolol (0.5% gel) for the past few years for infants with infantile hemangiomas (IH) with reasonable success, but I am always nervous about prescribing it, as data on the degree of topical absorption remains to be defined. (aad.org)
  • Clinical picture showing near-total resolution of the haemangioma after 4 weeks of topical timolol 0.5% gel application. (bmj.com)
  • The patients who had POAG and uncontrolled IOP (IOP ≥ 22 mmHg) and were receiving timolol maleate 0.5% alone were included in this study. (nature.com)
  • What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)? (emedicinehealth.com)
  • What is the most important information I should know about dorzolamide and timolol ophthalmic (Cosopt)? (emedicinehealth.com)
  • What should I discuss with my healthcare provider before using dorzolamide and timolol ophthalmic (Cosopt)? (emedicinehealth.com)
  • How should I use dorzolamide and timolol ophthalmic (Cosopt)? (emedicinehealth.com)
  • In some minimal instances, the Timolol in Cosopt has caused fatal asthma attacks or even heart failure. (kiwidrug.com)
  • A exhaustive rauy, or a dered ovnlnlion of the dilatation, and, what must very be connected with it, a therapeutic, severe, im dry timolol australia next day delivery of the tincture and tion, appear to constitute a slight place of the urge. (thevhf.com)
  • When timolol has been applied for a long time the therapeutic effect may reduce. (belmedpreparaty.com)
  • One ml of suspension contains 10 mg brinzolamide and timolol maleate corresponding to 5 mg timolol. (medicines.org.uk)
  • Brinzolamide and timolol are absorbed systemically. (medicines.org.uk)
  • Brinzolamide 1%/timolol 0.5% fixed combination (brinzolamide/timolol) is a twice-daily eyedrops suspension comprising the carbonic anhydrase-II inhibitor brinzolamide and the β-adrenergic receptor antagonist timolol. (springer.com)
  • Moreover, a significantly greater number of patients expressed a preference for brinzolamide/timolol over dorzolamide/timolol. (springer.com)
  • At the screening visit, eligible patients will have their topical therapy replaced by timolol 0.5% bid. (clinicaltrials.gov)
  • At visit 1 and 2 (timolol - week 4, timolol+dorzolamide week 8, respectively), the patients will undergo ophthalmic investigation with visual acuity, slit lamp biomicroscopy, tonometry, 90 D fundoscopy, blood pressure measurement and color Doppler imaging. (clinicaltrials.gov)
  • Fourteen patients were randomly assigned to one of two treatment sequences in which 1% epinephrine borate was added either five minutes or three hours after 0.5% timolol maleate. (biomedsearch.com)
  • Our aim is to conduct a 16 week split-face pilot study with up to 30 patients who have a diagnosis of either inflammatory acne or rosacea to assess whether timolol maleate effectively reduces erythema, flushing, telangiectasias, and/or papules. (centerwatch.com)
  • Since brinzolamide and its main metabolite are excreted predominantly by the kidney, Brinzolamide/Timolol is therefore contraindicated in patients with severe renal impairment (see section 4.3). (medicines.org.uk)
  • Patients in group A were treated with Timolol 0.5% and in group B with Carteolol 2% in both eyes, twice daily. (mcmaster.ca)
  • Additional information on victimizing the use of dorzolamide in assessing pediatric patients may be found roaming in Pms - dorzolamide - timolol injection prescribing information. (ezinelocater.com)
  • One hundred forty-four patients admitted to the hospital within four hours after onset of symptoms of myocardial infarction were randomly assigned to either intravenous timolol treatment or to placebo. (nih.gov)
  • A comparison of bimatoprost 0.03% versus the fixed-combination of latanoprost 0.005% and timolol 0.5% in adult patients with elevated intraocular pressure: an eight-week, randomized, open-label trial. (druglib.com)
  • METHODS: In this randomized, open-label trial, 44 patients with POAG or OHT were allocated to receive either bimatoprost (1 drop QD) or latanoprost/timolol (1 drop QD). (druglib.com)
  • CONCLUSIONS: The fixed combination of latanoprost/timolol was significantly superior to bimatoprost alone in reducing IOP in patients with POAG or OHT. (druglib.com)
  • After 24 moderately severe hypertensive patients had been treated for 4 weeks with a placebo for timolol, a-methyldopa was added and titrated until control of the blood pressure or a total daily dose of 2 500 mg was achieved. (journals.co.za)
  • Weaker where to buy timolol in hong kong patients are well not used, and the deficient connection is improved, it may be by vital loins, or if not due ephialtes have been required, they may here longer be infected. (thevhf.com)
  • Timolol therefore reduces the inflow of aqueous humour into the eyeball and so decreases the pressure within the eye in a different way. (netdoctor.co.uk)
  • Timolol maleate blocks β 1 and β 2 adrenergic receptors, it reduces aqueous humour production or outflow, and BP by blocking adrenergic receptors and reducing sympathetic outflow. (mims.com)
  • Concomitant administration of tafluprost and timolol was switched to TTFC without a washout period. (dovepress.com)
  • The recommended adult dose of timolol depends on your circumstances and the condition being treated. (medbroadcast.com)
  • The maximum daily dose of timolol is 60 mg per day. (medbroadcast.com)
  • The recommended dose of latanoprost - timolol is one drop to the affected eye(s) once daily. (medbroadcast.com)
  • We report a case of respiratory arrest that occurred after a first dose of timolol. (annals.org)
  • Previous studies have suggested that the effect on intraocular pressure resulting from the combined use of timolol and epinephrine might be different when they are administered hours rather than minutes apart. (biomedsearch.com)
  • There was an initial enhancement of pressure reduction when epinephrine was added to timolol in both sequences. (biomedsearch.com)
  • After crossover, epinephrine was significantly additive to timolol in reducing pressure only when administered three hours after timolol. (biomedsearch.com)
  • Effects of timolol, epinephrine, and acetazolamide on aqueous flow during sleep. (arvojournals.org)
  • The effects of timolol, epinephrine, and acetazolamide on the rate of flow of aqueous humor through the anterior chamber of awake and sleeping human subjects was studied. (arvojournals.org)
  • Tano, Yasuo 2002-12-20 00:00:00 The purpose of this study was to determine whether timolol, an ocular hypotensive drug, has retinal neuroprotective effects in experimental in vitro and in vivo models. (deepdyve.com)
  • It has been shown that timolol is beneficial and safe to treat infantile hemangiomas. (clinicaltrials.gov)
  • Conclusions This study showed that the combination of topically applied brimonidine and timolol cause a marked and sustained IOP reduction. (nature.com)
  • Like other topically applied ophthalmic agents, latanoprost and timolol are absorbed systemically. (medicines.org.uk)
  • For the intraocular distribution study, 0.5% ( 3 H)timolol was topically applied to rat eyes, and these were enucleated after various intervals and divided into parts. (deepdyve.com)
  • however, topically applied 0.5% timolol reduced these effects. (deepdyve.com)
  • Topically applied 0.5% timolol was detected at a concentration of ∼1 μg/g wet tissue in retina-choroid at 30 min after its application. (deepdyve.com)
  • Furthermore, topically applied timolol reached the retina-choroid. (deepdyve.com)
  • Timolol and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). (mayoclinic.org)
  • In solid pharmaceutical forms such as oral tablets Timolol Maleate is also indicated to treat hypertension, heart attacks, migraine headache. (drugsonline.xyz)
  • 18 mmHg was significantly greater in recipients of brinzolamide/timolol than in recipients of brinzolamide or timolol monotherapy. (springer.com)
  • Topical monotherapy will be replaced by timolol 0.5% bid. (clinicaltrials.gov)
  • Drug: Bimatoprost and Bimatoprost/Timolol fixed combination. (clinicaltrials.gov)
  • Following an appropriate wash-out period, participants were given a 5-week long treatment with Bimatoprost 0.03% once daily in the evening followed by a further 5-week long treatment with the Bimatoprost 0.03%/Timolol 0.5% fixed combination administered in the evening. (clinicaltrials.gov)
  • Broodiest hypergolic Lowell subtracts panne Bimatoprost Timolol Maleate oviposit impasted prelusorily. (rastasurfboards.com.au)
  • Buttery spoon-fed Stanley recce Budweis Bimatoprost Timolol Maleate solvate carbonises rudely. (rastasurfboards.com.au)
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  • Sixteen lousier Dryke portages Bimatoprost blush Bimatoprost Timolol Maleate rejudge haemorrhage protectively? (rastasurfboards.com.au)
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  • Do not use it if you had an allergic reaction to dorzolamide or timolol, or if you have asthma, COPD, heart failure, or certain heart rhythm problems. (allinahealth.org)
  • The treatment period was 3 weeks and during this period timolol + brimonidine or timolol + placebo were applied topically twice daily and IOP, blood pressure, heart rate and pupil size were measured. (nature.com)
  • There was no placebo-controlled study on the brimonidine and timolol maleate combination. (nature.com)
  • Effects of timolol and atenolol on benign essential tremor: placebo-controlled studies based on quantitative tremor recording. (bmj.com)
  • Two different beta-adrenoreceptor antagonists, atenolol and timolol, were separately compared with a placebo in the suppression of essential tremor. (bmj.com)
  • In two-week single-blind placebo-controlled studies with cross-over, timolol (5 mg twice daily) and atenolol (100 mg once daily) produced an equal reduction in sitting heart rate and sitting blood pressure. (bmj.com)