Timolol
Ophthalmic Solutions
Prostaglandins F, Synthetic
Ocular Hypertension
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Adrenergic beta-Antagonists
Glaucoma, Open-Angle
Propanolamines
Benzalkonium Compounds
Preservatives, Pharmaceutical
Cloprostenol
Aqueous Humor
Metipranolol
Carteolol
Antihypertensive Agents
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Glaucoma
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
Prostaglandins, Synthetic
Fluorophotometry
Conjunctiva
Carbonic Anhydrase I
Pilocarpine
Pharmaceutical Vehicles
Sick Sinus Syndrome
A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.
Vivisection
Pacemaker, Artificial
Students, Pharmacy
Hydrochlorothiazide
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
Hypertension
Pressure
Protective Devices
Drugs, Chinese Herbal
Night Vision
Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Migraine Disorders
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Headache
Migraine with Aura
A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Sumatriptan
Drug Information Services
Drug Overdose
Drug Users
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Central injections of capsaicin cause antidiuresis mediated through neurokinin-1 receptors in rat hypothalamus and vasopressin release. (1/309)
Intracerebroventricular injections of capsaicin at 100-500 nmol elicited dose-dependent decreases in urine outflow volume in anesthetized, hydrated rats. The capsaicin (500 nmol)-induced antidiuresis was inhibited by pretreatment with CP96345 (30 nmol, a neurokinin-1-receptor antagonist), but not by that with phenoxybenzamine (20 nmol, an alpha-adrenoceptor antagonist), timolol (100 nmol, a beta-adrenoceptor antagonist) or atropine (300 nmol, a muscarinic antagonist) into the hypothalamic supraoptic nucleus (SON). Intravenous injections of d(CH2)5-D-Tyr(Et)VAVP (50 microg/kg, a vasopressin-receptor antagonist) completely blocked the antidiuresis. In intra-SON microdialysis experiments, acetylcholine concentration in the perfusate of the capsaicin-injected rats was not different from that of the vehicle-injected rats. These findings suggested that capsaicin stimulated substance P release in the SON and caused the antidiuresis as a result of the increased release of vasopressin into the circulation from the neurohypophysis mediated through neurokinin-1 receptors in the SON. (+info)Mitigation of caffeine-induced fetopathy in mice by pretreatment with beta-adrenergic blocking agents. (2/309)
In a previous experiment, fetopathic effects of caffeine were significantly reduced by pretreatment with propranolol at dosage levels of 2.5 to 10 mg/kg. The present experiments were undertaeken to investigate the relation between time intervals of propranolol pretreatment and its effect on reducing fetopathy. Furthermore, the effect of timolol, another beta-adrenergic blocking agent, on reducing fetopathy was compared with that of propranolol. Propranolol (5 mg/kg) administered 15, 30 or 60 minutes before caffeine treatment significantly reduced the caffeine-induced fetopathy. The optimal effect was found when propranolol was given 30 minutes before caffine. The reduction in fetopathy by timolol pretreatment was comparable to that of propranolol. The results lend support to the hypothesis that the fetopathic effect of caffeine is linked with released catecholamines in material or fetal issues of mice. (+info)Constitutively active mutants of the beta1-adrenergic receptor. (3/309)
We provide the first evidence that point mutations can constitutively activate the beta(1)-adrenergic receptor (AR). Leucine 322 of the beta(1)-AR in the C-terminal portion of its third intracellular loop was replaced with seven amino acids (I, T, E, F, C, A and K) differing in their physico-chemical properties. The beta(1)-AR mutants expressed in HEK-293 cells displayed various levels of constitutive activity which could be partially inhibited by some beta-blockers. The results of this study might have interesting implications for future studies aiming at elucidating the activation process of the beta(1)-AR as well as the mechanism of action of beta-blockers. (+info)Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with beta adrenergic antagonists. French Latanoprost Study Group, and the Swedish Latanoprost Study Group. (4/309)
AIMS: To compare the effect on intraocular pressure (IOP) of latanoprost monotherapy and timolol-pilocarpine in patients with glaucoma or ocular hypertension with inadequately controlled IOP on topical beta adrenergic antagonists. METHODS: This was a multicentre, randomised, observer masked, 6 week study performed in France and Sweden. 23 centres enrolled 237 patients with glaucoma or ocular hypertension and an IOP of at least 22 mm Hg on treatment with topical beta adrenergic antagonists, alone or in combination. After a 21 day run in period on timolol 0.5% twice daily, patients were randomised either to latanoprost 0.005% once daily or to a fixed combination of timolol-pilocarpine twice daily. Changes in mean diurnal IOP from the baseline to the 6 week visit were determined with an analysis of covariance. RESULTS: Mean diurnal IOP was statistically significantly decreased from baseline in both groups (p<0.001). Switching to latanoprost treatment reduced mean diurnal IOP by 5.4 (SEM 0.3) mm Hg (ANCOVA -22%) and switching to timolol-pilocarpine treatment reduced mean diurnal IOP by 4.9 (0.4) mm Hg (-20%). Blurred vision, decreased visual acuity, decreased twilight vision, and headache were statistically significantly more frequent in the timolol-pilocarpine group. CONCLUSIONS: Latanoprost monotherapy was at least as effective as fixed combination timolol-pilocarpine twice daily treatment in reducing mean diurnal IOP in patients not adequately controlled on topical beta adrenergic antagonists. Latanoprost was better tolerated than timolol-pilocarpine regarding side effects. These results indicate that a switch to latanoprost monotherapy can be attempted before combination therapy is initiated. (+info)Effects of topical nipradilol, a beta blocking agent with alpha blocking and nitroglycerin-like activities, on intraocular pressure and aqueous dynamics in humans. (5/309)
AIMS: To study the effects of topical nipradilol, a non-selective beta blocker with alpha blocking and nitroglycerin-like activities, on intraocular pressure (IOP) and aqueous humour dynamics in normal humans and in patients with ocular hypertension. METHODS: Nipradilol (0.06%, 0.125%, 0.25%, 0.5%) was applied to normal volunteers (n = 12) to test for IOP lowering effects. In a second group of normal volunteers (n = 11), nipradilol (0.125% and 0.25%) and timolol (0. 5%) were compared for IOP lowering effects. After a single administration of 0.25% nipradilol, IOP, flare intensity in the anterior chamber, aqueous flow, uveoscleral outflow, tonographic outflow facility, and episcleral venous pressure were either directly measured or mathematically calculated. Topical nipradilol (0.25%) was administered to 24 patients with ocular hypertension twice daily for 8 weeks. RESULTS: Administration of 0.25% nipradilol decreased IOP with a maximum reduction of 4.2 mm Hg lasting 12 hours. A single instillation of both 0.25% nipradilol and 0.5% timolol reduced the IOP in normotensive human subjects to the same degree. A single instillation of 0.25% nipradilol decreased the aqueous flow rate in the treated eye by 20%. Nipradilol produced no significant effect in tonographic outflow facility or episcleral venous pressure, but uveoscleral outflow was increased. In patients with ocular hypertension, twice daily instillation of 0.25% nipradilol decreased IOP without tachyphylaxis for the 8 week test period. CONCLUSION: Topical nipradilol (0.25%) reduced IOP by decreasing the aqueous flow rate and probably also by increasing uveoscleral outflow. Nipradilol should be further investigated as a new antiglaucoma drug. (+info)Meal-induced insulin secretion in dogs is mediated by both branches of the autonomic nervous system. (6/309)
We investigated the relationship between autonomic activity to the pancreas and insulin secretion in chronically catheterized dogs when food was shown, during eating, and during the early absorptive period. Pancreatic polypeptide (PP) output, pancreatic norepinephrine spillover (PNESO), and arterial epinephrine (Epi) were measured as indexes for parasympathetic and sympathetic nervous activity to the pancreas and for adrenal medullary activity, respectively. The relation between autonomic activity and insulin secretion was confirmed by autonomic blockade. Showing food to dogs initiated a transient increase in insulin secretion without changing PP output or PNESO. Epi did increase, suggesting beta(2)-adrenergic mediation, which was confirmed by beta-adrenoceptor blockade. Eating initiated a second transient insulin response, which was only totally abolished by combined muscarinic and beta-adrenoceptor blockade. During absorption, insulin increased to a plateau. PP output showed the same pattern, suggesting parasympathetic mediation. PNESO decreased by 50%, suggesting withdrawal of inhibitory sympathetic neural tone. We conclude that 1) the insulin response to showing food is mediated by the beta(2)-adrenergic effect of Epi, 2) the insulin response to eating is mediated both by parasympathetic muscarinic stimulation and by the beta(2)-adrenergic effect of Epi, and 3) the insulin response during early absorption is mediated by parasympathetic activation, with possible contribution of withdrawal of sympathetic neural tone. (+info)Betaxolol, a beta(1)-adrenoceptor antagonist, reduces Na(+) influx into cortical synaptosomes by direct interaction with Na(+) channels: comparison with other beta-adrenoceptor antagonists. (7/309)
Betaxolol, a beta(1)-adrenoceptor antagonist used for the treatment of glaucoma, is known to be neuroprotective in paradigms of ischaemia/excitotoxicity. In this study, we examined whether betaxolol and other beta-adrenoceptor antagonists interact directly with neurotoxin binding to sites 1 and 2 of the voltage-sensitive sodium channel (Na(+) channel) in rat cerebrocortical synaptosomes. Betaxolol inhibited specific [(3)H]-batrachotoxinin-A 20-alpha-benzoate ([(3)H]-BTX-B) binding to neurotoxin site 2 in a concentration-dependent manner with an IC(50) value of 9.8 microM. Comparison of all the beta-adrenoceptor antagonists tested revealed a potency order of propranolol>betaxolol approximately levobetaxolol>levobunolol approximately carteolol>/=timolol>atenolol. None of the drugs caused a significant inhibition of [(3)H]-saxitoxin binding to neurotoxin receptor site 1, even at concentrations as high as 250 microM. Saturation experiments showed that betaxolol increased the K(D) of [(3)H]-BTX-B binding but had no effect on the B(max). The association kinetics of [(3)H]-BTX-B were unaffected by betaxolol, but the drug significantly accelerated the dissociation rate of the radioligand. These findings argue for a competitive, indirect, allosteric mode of inhibition of [(3)H]-BTX-B binding by betaxolol. Betaxolol inhibited veratridine-stimulated Na(+) influx in rat cortical synaptosomes with an IC(50) value of 28. 3 microM. Carteolol, levobunolol, timolol and atenolol were significantly less effective than betaxolol at reducing veratridine-evoked Na(+) influx. The ability of betaxolol to interact with neurotoxin site 2 of the Na(+) channel and inhibit Na(+) influx may have a role in its neuroprotective action in paradigms of excitotoxicity/ischaemia and in its therapeutic effect in glaucoma. (+info)Effects of glaucoma medications on the cardiorespiratory and intraocular pressure status of newly diagnosed glaucoma patients. (8/309)
AIMS: To evaluate the short term cardiovascular, respiratory, and intraocular pressure (IOP) effects of four glaucoma medications in newly diagnosed glaucoma patients. METHODS: 141 newly diagnosed glaucoma patients were recruited and underwent a full ocular, cardiovascular, and respiratory examination, including an electrocardiogram (ECG) and spirometry. They were prescribed one of four topical glaucoma medications and reviewed 3 months later. One eye of each patient was randomly chosen for analysis, performed using analysis of variance and the chi(2) test. RESULTS: Latanoprost had the greatest mean IOP lowering effect in both the primary open angle glaucoma (POAG) (p = 0.005) and the "presumed" normal tension glaucoma (NTG) groups (p = 0.33), reducing the IOP by 8.9 mm Hg and 4.1 mm Hg respectively. Timolol was associated with lowered pulse rates and reductions in the spirometry measurements. 41% of patients using brimonidine complained of systemic side effects and over 55% of patients using betaxolol complained of ocular irritation. 28% of patients required an alteration in their glaucoma management. CONCLUSIONS: Latanoprost appears to be a useful primary treatment for glaucoma patients, in view of superior IOP control and a low incidence of local and systemic side effects. Timolol causes a reduction in measurements of respiratory function, a concern in view of the potential subclinical reversible airways disease in the elderly glaucoma population. Brimonidine is associated with substantial, unpredictable systemic side effects and betaxolol causes ocular irritation and weak IOP control. Spirometry is advised in all patients receiving topical beta blocker therapy to control their glaucoma. (+info)
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Herbert E. Kaufman
Kaufman identified timolol as a possible therapeutic agent to treat glaucoma and with Thomas Zimmerman, conduct basic science ... Yale researcher Marvin Sears, observed that timolol, a beta-adrenergic agent, had an intraocular pressure lowering effect in ... PMID 14064628.CS1 maint: multiple names: authors list (link) Zimmerman TJ, Kaufman HE (1977). "Timolol. A Beta-Adrenergic ... co-developed timolol with Thomas Zimmerman, a new class of medications to treat glaucoma; corneal storage media for eye banks; ...
Hemangioma
Topical beta blockers such as timolol. These can also be used in conjunction with oral beta blockers for greater effect, which ... "Oral propranolol combined with topical timolol for compound infantile hemangiomas: a retrospective study". Scientific Reports. ...
Infantile hemangioma
Topical timolol maleate, a nonselective beta blocker available in a gel-forming solution approved for the treatment of glaucoma ... 2013). "Topical timolol for small hemangiomas of infancy". Pediatr Dermatol. 30 (2): 245-9. doi:10.1111/j.1525-1470.2012.01723. ... 2012). "Timolol maleate 0.5% or 0.1% gel-forming solution for infantile hemangiomas: a retrospective multicenter cohort study ... Since that time, topical timolol maleate in addition to oral propranalol has become a common therapy for infantile hemangiomas ...
Tazolol
Timolol Niridazole Fenclozic acid Strosberg AM (August 1976). "The cardiovascular pharmacology and hemodynamic activity of ...
Schedule H
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
Beta blocker
Atenolol, metoprolol (immediate release), propranolol (immediate release), timolol, carvedilol (after left ventricular ... Intermediate lipophilicity: metoprolol, bisoprolol, carvedilol, acebutolol, timolol, pindolol. *Low lipophilicity (also known ...
Bimatoprost
... typically timolol). Studies have shown bimatoprost to be more effective than timolol in reduction of intraocular pressure (IOP ... Bimatoprost does not negatively interact with timolol eye drops. Bimatoprost is a structural analog of prostaglandin F2α (PGF2α ...
Dorzolamide
"Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol ... It is also available as the combination dorzolamide/timolol. Common side effects include eye discomfort, eye redness, taste ...
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Examples beta blockers are atenolol, metoprolol, nadolol, pindolol, propranolol, and timolol. Metoprolol is used to treat ...
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Nonsteroidal anti-inflammatory drugs (NSAIDs) can either reduce or increase the effect of tafluprost.[1] Timolol eye drops, a ...
Discovery and development of beta-blockers
All β-blockers used systemically are delivered as racemate, except for timolol. Three different types of β-adrenergic receptors ...
Ciliary body
Timolol, Levobunolol, and Betaxolol are common beta blockers prescribed to treat glaucoma. Alpha-adrenergic agonists work by ...
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Limited basic and clinical evidence suggest that topical beta-blockers, such as timolol, may induce regression of localized ... topical timolol gel". Journal of the American Academy of Dermatology. 76 (1): 153-155. doi:10.1016/j.jaad.2016.08.041. PMID ...
Attractin
Mori M, Sakurai M, Araie M (1993). "[Topical timolol and blood-aqueous barrier permeability to protein in human eyes]". Nippon ...
Brimonidine
It is also the active ingredient of brimonidine/timolol along with timolol maleate. A 2017 Cochrane review found insufficient ...
Carbonic anhydrase inhibitor
The combination of brinzolamide with timolol is marketed under the trade name Azarga.[citation needed] Some diuretics inhibit ...
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"Carbopol/Chitosan Based pH Triggered In Situ Gelling System for Ocular Delivery of Timolol Maleate". Sci Pharm. 78 (4): 959-76 ...
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Allergies are rare, but seem to be more common than under the related drug timolol. If the substance reaches the nasal mucosa ... "Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface". Cornea. 22 (8): 709-15. doi ...
Latanoprost
... was more effective than timolol 0.5% twice daily in 3 of 4 large (n = 163 to 267) randomised, double-blind trials. ... Meta-analysis suggests that latanoprost is more effective than timolol in lowering intraocular pressure (IOP). However, it ... 2000). "Comparison of the intraocular pressure-lowering effect of latanoprost and timolol in patients with chronic angle ... 8.2 and 8.8 mm Hg vs 5.2 and 5.7 mm Hg for latanoprost vs timolol at 12 and 2 weeks, respectively). Listed from most to least ...
ATC 코드 S01 - 위키백과, 우리 모두의 백과사전
S01ED01 Timolol. S01ED02 Betaxolol. S01ED03 Levobunolol. S01ED04 Metipranolol. S01ED05 Carteolol. S01ED06 Befunolol. S01ED51 ... Timolol, combinations. S01ED52 Betaxolol, combinations. S01ED54 Metipranolol, combinations. S01ED55 Carteolol, combinations. ...
Brinzolamide
Dorzolamide/timolol combination versus concomitant administration of brimonidine and timolol: six-month comparison of efficacy ... anhydrase inhibitors Moderate-to-severe chronic kidney disease or liver disease The combination of brinzolamide with timolol is ...
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The principal medication known to affect the retina are:- latanoprost, epinephrine, rosiglitazone, timolol and ...
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Some drugs that have been successfully loaded via this method are: timolol, norfloxacin, ketotifen, polyvinlypyrrolidone, and ...
Migraine
The beta blocker Timolol is also effective for migraine prevention and in reducing migraine attack frequency and severity. ...
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Timolol: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Timolol comes as a tablet to take by mouth. It is usually taken one or two times a day. To help you remember to take timolol, ... Timolol helps control your condition but will not cure it. Continue to take timolol even if you feel well. Do not stop taking ... Before taking timolol,. *tell your doctor and pharmacist if you are allergic to timolol, any other medications, or any of the ...
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Timolol. Sinus bradycardia and atrioventricular block in an elderly patient: case report ... Walia HS, Walia SS, Emanuel ME.Sick sinus syndrome associated with topical timolol maleate instillation. Journal of ... Timolol. React. Wkly. 1425, 35 (2012). https://doi.org/10.2165/00128415-201214250-00122 ...
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Timolol Ophthalmic: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Timolol eye drops and gel-forming solution control glaucoma but do not cure it. Continue to use timolol even if you feel well. ... Before using timolol eye drops or gel-forming solution,. *tell your doctor and pharmacist if you are allergic to timolol, beta ... Use timolol exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. ...
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... timolol and latanoprost timolol and travoprost Timolol is marketed under many trade names worldwide. Timolol eye drops are ... For ophthalmic use, timolol is also available combined: with carbonic anhydrase inhibitors: timolol and brinzolamide timolol ... Timolol is a non-selective beta blocker. g Timolol was patented in 1968, and came into medical use in 1978. It is on the World ... "Timolol". Drugs.com. Archived from the original on 7 March 2016. Retrieved 28 December 2016. "Timolol eent". The American ...
Timolol OSL - Drugs.com
A list of US medications equivalent to Timolol OSL is available on the Drugs.com website. ... Timolol OSL is a medicine available in a number of countries worldwide. ... Ingredient matches for Timolol OSL. Timolol. Timolol is reported as an ingredient of Timolol OSL in the following countries:. * ... Timolol OSL. Timolol OSL may be available in the countries listed below. ...
DuoTrav eye drops (travoprost, timolol)
... travoprost and timolol maleate. These are both medicines that lower raised pressure within the eye. They work in different ways ... DuoTrav eye drops (travoprost, timolol). DuoTrav eye drops contain two active ingredients, travoprost and timolol maleate. ... The timolol in these eye drops may enhance the effects of the following medicines taken by mouth, which may result in low blood ... Timolol is a type of medicine called a beta-blocker. These medicines block beta-receptors in various parts of the body. ...
Ganfort eye drops (bimatoprost, timolol)
... bimatoprost and timolol maleate. These are both medicines that decrease raised pressure within the eye. They work in different ... Ganfort eye drops (bimatoprost, timolol). Ganfort eye drops contain two active ingredients, bimatoprost and timolol maleate. ... The timolol in these eye drops may enhance the effects of the following medicines taken by mouth, which may result in low blood ... Timolol can be absorbed into the bloodstream after being applied into the eye and may mask the symptoms of low blood sugar, ...
Brinzolamide/Timolol | SpringerLink
... brinzolamide/timolol) is a twice-daily eyedrops suspension comprising the carbonic anhydrase-II inhibitor brinzolamide and the ... Brinzolamide 1%/timolol 0.5% fixed combination (brinzolamide/timolol) is a twice-daily eyedrops suspension comprising the ... The safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with ... Moreover, a significantly greater number of patients expressed a preference for brinzolamide/timolol over dorzolamide/timolol. ...
Prescriber Checkup | DORZOLAMIDE-TIMOLOL
Brinzolamide and Timolol | Memorial Sloan Kettering Cancer Center
Timolol-Hydrochlorothiazide Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Timolol And Hydrochlorothiazide (Oral Route) Side Effects - Mayo Clinic
Information about this timolol-and-hydrochlorothiazide-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal ... Timolol is a beta-blocker. It works by affecting the response to some nerve impulses in certain parts of the body, like the ... Timolol and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to ... Appropriate studies have not been performed on the relationship of age to the effects of timolol and hydrochlorothiazide ...
Brimonidine And Timolol (Ophthalmic Route) Proper Use - Mayo Clinic
Brimonidine and timolol ophthalmic (eye) drops are used to treat increased pressure in the eye caused by glaucoma or a ... Information about this brimonidine-and-timolol-ophthalmic-route. Pregnancy Category. Explanation. All Trimesters. C. Animal ... performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of brimonidine and timolol ... performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of brimonidine and timolol ...
Timolol - DrugBank
Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the ... Act Latanoprost/timolol. Timolol (5 mg) + Latanoprost (50 mcg). Solution. Ophthalmic. Actavis Pharma Company. 2015-09-29. Not ... Timolol hemihydrate. 817W3C6175. 91524-16-2. TWBNMYSKRDRHAT-RCWTXCDDSA-N. Timolol maleate. P8Y54F701R. 26921-17-5. ... Similar to propranolol and nadolol, timolol is a non-selective, beta-adrenergic receptor antagonist. Timolol does not have ...
brimonidine and timolol ophthalmic | Cigna
Timolol is a beta-blocker that also reduces pressure inside the eye. Brimonidine and timolol ophthalmic (for the eyes) is used ... How should I take brimonidine and timolol ophthalmic?. How should I take brimonidine and timolol ophthalmic?. Follow all ... What should I avoid while taking brimonidine and timolol ophthalmic?. What should I avoid while taking brimonidine and timolol ... What is brimonidine and timolol ophthalmic?. What is brimonidine and timolol ophthalmic?. Brimonidine reduces the amount of ...
dorzolamide and timolol ophthalmic | Cigna
Timolol ophthalmic is a beta-blocker that also reduces pressure inside the eye. Dorzolamide and timolol ophthalmic (for the ... What should I avoid while using dorzolamide and timolol ophthalmic?. Dorzolamide and timolol ophthalmic can cause blurred ... What other drugs will affect dorzolamide and timolol ophthalmic?. Other drugs may interact with dorzolamide and timolol ... Dorzolamide and timolol ophthalmic (for the eyes) is a combination medicine used to treat certain types of glaucoma and other ...
DailyMed - DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE solution/ drops
Timolol Maleate (UNII: P8Y54F701R) (Timolol Anhydrous - UNII:5JKY92S7BR) Timolol Anhydrous. 5 mg in 1 mL. ... dorzolamide HCl 2 % / timolol maleate 0.5 % Ophthalmic Solution. PSN. 2. 1923432. dorzolamide 20 MG/ML / timolol 5 MG/ML ... Timolol Maleate In a study of plasma drug concentrations in six subjects, the systemic exposure to timolol was determined ... Timolol Maleate is stable at room temperature.. Dorzolamide HCl/Timolol Maleate Ophthalmic Solution is supplied as a sterile, ...
timolol ophthalmic
| UW Health | Madison, WI
Timolol ophthalmic (for the eyes) is used to treat open-angle glaucoma and other causes of high pressure inside the eye. ... Timolol ophthalmic may also be used for purposes not listed in this medication guide. ... Timolol is a beta-blocker that also reduces pressure inside the eye. ... What should I avoid while using timolol ophthalmic?. Timolol ophthalmic can cause blurred vision. Be careful if you drive or do ...
Timolol - Side Effects, Dosage, Interactions - Drugs
Timolol is used to treat high blood pressure. It is also used to prevent migraine headaches, treat chest pain & improve chances ... Timolol Warnings. Timolol contains a black box warning because it may cause chest pain or a heart attack if you stop taking it ... Pregnancy and Timolol. Its not known whether timolol could harm an unborn baby if taken during pregnancy, but it has been ... Timolol and Alcohol. Alcohol can worsen certain side effects of timolol.. Talk to your doctor before drinking alcoholic ...
Timolol Maleate - Adventist HealthCare
Replenish Depleted Nutrients none Reduce Side Effects Coenzyme Q10 In a group of 16 glaucoma patients treated with a timolol ... In a group of 16 glaucoma patients treated with a timolol eye preparation, six weeks of oral coenzyme Q10 (90 mg per day) was ... reported to reduce timolol-induced cardiovascular side effects without affecting intraocular pressure treatment. ...
Timolol for the Treatment of Acne and Rosacea - Tabular View - ClinicalTrials.gov
Drug: Timolol Apply timolol on half of the participants face for 8 weeks. Then treat both sides of face for 8 weeks. ... Timolol for the Treatment of Acne and Rosacea. The safety and scientific validity of this study is the responsibility of the ... Timolol for the Treatment of Acne and Rosacea Brief Summary This research is being done to determine the safety and ... Timolol is approved by the Food and Drug Administration (FDA) for the treatment of glaucoma. In dermatology, it has been used ...
A short term study of the additive effect of timolol and brimonidine on intraocular pressure | Eye
The treatment period was 3 weeks and during this period timolol + brimonidine or timolol + placebo were applied topically twice ... The timolol + placebo combination had no clinically significant IOP-lowering effect (P , 0.05). No clinically significant side ... Conclusions This study showed that the combination of topically applied brimonidine and timolol cause a marked and sustained ... on therapy receiving timolol maleate 0.5% twice daily, with IOP greater than or equal to 22 mmHg in one eye. ...
TIMOLOL MALEATE Patient Assistance Program
TIMOPTIC 0.25% AND 0.5% (TIMOLOL MALEATE OPHTHALMIC SOLUTION) in OCUDOSE
TIMOPTIC 0.25% AND 0.5% (TIMOLOL MALEATE OPHTHALMIC SOLUTION) in OCUDOSE
It may be used when a patient is sensitive to the preservative in TIMOPTIC (timolol maleate ophthalmic solution), benzalkonium ... In an epidemiologic survey, patients who were switched to a preservative-free timolol experienced fewer ocular symptoms, such ... For patients who are sensitive to the preservative in TIMOPTIC (timolol maleate ophthalmic solution), benzalkonium chloride ( ... TIMOPTIC 0.25% AND 0.5% (TIMOLOL MALEATE OPHTHALMIC SOLUTION) in OCUDOSE : Additional information ...
Teva-Timolol - Uses, Side Effects, Interactions - MedBroadcast.com
Timolol is also used for the prevention of migraine headaches but is not useful for treatment of a headache once it has started ... Timolol belongs to the class of medications called beta-blockers. It is used for the treatment of high blood pressure. It is ... 01947796 TEVA-TIMOLOL 5MG TABLET. 01947818 TEVA-TIMOLOL 10MG TABLET. 01947826 TEVA-TIMOLOL 20MG TABLET. ... Timolol blocks the action of chemicals that increase the hearts workload. Beta-blockers such as timolol lower the heart rate, ...
Dom-Timolol - Uses, Side Effects, Interactions - MedBroadcast.com
Timolol eye drops are used to treat glaucoma and increased pressure in the eye. ... Dom-Timolol: This medication belongs to the family of medications called beta-blockers. ... 02238770 DOM-TIMOLOL 0.25% OPHTHALMIC LIQUID. 02238771 DOM-TIMOLOL 0.5% OPHTHALMIC LIQUID. ... The usual starting dose is one drop of timolol 0.25% solution in the affected eye(s) twice daily. If the response to the drops ...
Blocadren (timolol) Side Effects, Interactions, Uses & Drug Imprint
... timolol) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid. ... If you are taking timolol to prevent migraine headaches: It may take 6 to 8 weeks of daily use before timolol is fully ... Timolol is also used to prevent migraine headaches.. Timolol may also be used for purposes not listed in this medication guide. ... Timolol is used to treat hypertension (high blood pressure). Timolol is sometimes given with other blood pressure medication. ...
Ophthalmic SolutionGlaucoma0.25DropsMedicationAssociated with topical timololTravoprostTake timololEfficacyDORZOLAMIDE HCLAdministration of timololDrugsHydrochlorideBlocadrenMaleate ophthalmicBrimonidine tartratePropranololDosagePreservativeSolutionIngredientsMedicationsSide effects of timololTopical timolol 0.5Receiving timolol maleateCosoptTherapeuticBrinzolamide and TimololCarbonicPatientsAqueous humourDosesConcomitantDoseEpinephrineOcular hypotensiveInfantile hemangiomasTopically appliedHypertensionMonotherapyBimatoprostAllergic reactionPlacebo
Ophthalmic Solution15
- These highlights do not include all the information needed to use Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution safely and effectively. (nih.gov)
- See full prescribing information for Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution. (nih.gov)
- Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution is a carbonic anhydrase inhibitor with a beta-adrenergic receptor blocking agent indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. (nih.gov)
- The IOP-lowering of Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution twice daily was slightly less than that seen with the concomitant administration of 0.5% timolol twice daily, and 2% dorzolamide three times daily. (nih.gov)
- The dose is one drop of Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution in the affected eye(s) two times daily. (nih.gov)
- Potential additive effect of oral carbonic anhydrase inhibitor with Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution. (nih.gov)
- Dorzolamide HCl/Timolol Maleate Ophthalmic Solution is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time). (nih.gov)
- For patients who are sensitive to the preservative in TIMOPTIC (timolol maleate ophthalmic solution), benzalkonium chloride (BAK), TIMOPTIC in OCUDOSE is a preservative-free eye drop for reducing intraocular pressure. (bausch.com)
- It may be used when a patient is sensitive to the preservative in TIMOPTIC (timolol maleate ophthalmic solution), benzalkonium chloride, or when use of a preservative-free topical medication is advisable. (bausch.com)
- Teva discontinued dorzolamide and timolol ophthalmic solution in April 2018. (ashp.org)
- Bausch Health had dorzolamide and timolol ophthalmic solution on shortage due to manufacturing delays. (ashp.org)
- Sandoz has dorzolamide/timolol 2%/0.5% ophthalmic solution in 10 mL bottles on back order and the company cannot estimate a release date. (ashp.org)
- Patient with certain types of high pressure inside eyes often looking for Cheap Dorzolamide with Timolol ophthalmic solution online as Cosopt generic from Merck pharmaceutical company. (drugsonline.xyz)
- People diagnosed with ocular hypertension have to know Where to buy cheap Combigan generic containing Brimonidine Tartrate 0.2% and Timolol Maleate 0.5% ophthalmic solution. (drugsonline.xyz)
- Long-term experience with timolol ophthalmic solution in patients with open-angle glaucoma. (harvard.edu)
Glaucoma39
- Ophthalmic timolol is used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision. (medlineplus.gov)
- Timolol eye drops and gel-forming solution control glaucoma but do not cure it. (medlineplus.gov)
- A Cochrane review compared the effect of timolol versus brimonidine in slowing the progression of open angle glaucoma in adults but found insufficient evidence to come to conclusions. (wikipedia.org)
- Brinzolamide/timolol produced clinically relevant reductions in mean intraocular pressure (IOP) from baseline and was more effective than brinzolamide or timolol monotherapy in lowering IOP in a 6-month, randomized, phase III trial in patients with open-angle glaucoma or ocular hypertension (n = 523). (springer.com)
- Brimonidine and timolol ophthalmic (eye) drops are used to treat increased pressure in the eye caused by glaucoma or a condition called hypertension of the eye. (mayoclinic.org)
- Brimonidine and timolol ophthalmic (for the eyes) is used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). (cigna.com)
- Dorzolamide and timolol ophthalmic (for the eyes) is a combination medicine used to treat certain types of glaucoma and other causes of high pressure inside the eye. (cigna.com)
- Timolol also comes in an ophthalmic formulation to treat glaucoma (an eye condition). (everydayhealth.com)
- In a group of 16 glaucoma patients treated with a timolol eye preparation, six weeks of oral coenzyme Q10 (90 mg per day) was reported to reduce timolol-induced cardiovascular side effects without affecting intraocular pressure treatment. (adventisthealthcare.com)
- Timolol is approved by the Food and Drug Administration (FDA) for the treatment of glaucoma. (clinicaltrials.gov)
- Purpose To evaluate the additive ocular hypotensive effect of the combination of brimonidine and timolol on intraocular pressure (IOP) reduction in patients with glaucoma. (nature.com)
- Methods This was a prospective, randomized, double-masked, crossover study in 20 patients with primary open angle glaucoma (POAG) on therapy receiving timolol maleate 0.5% twice daily, with IOP greater than or equal to 22 mmHg in one eye. (nature.com)
- All patients met the following criteria: age older than 22 years, a clinical diagnosis of primary open-angle glaucoma, patients already receiving timolol twice daily, corrected visual acuity of 20/80 or better in each eye. (nature.com)
- Patients were excluded from the study for any of the following reasons: active ocular infection and ocular disease other than glaucoma (blepharitis or cataract e.t), use of systemic and topical medications except timolol, prior treatment with any ocular surgery or laser therapy, contraindications to the use of alpha-adrenoreceptor agonist, female patients who were pregnant, lactating, or unstable cardiopulmonary disease. (nature.com)
- The purpose of this study is to examine the ocular hypotensive effect of Bimatoprost and the potential additional effect of the Bimatoprost/Timolol fixed combination in eyes with ocular hypertension, primary open angle glaucoma or exfoliation glaucoma. (clinicaltrials.gov)
- Efficacy Of The Bimatoprost/Timolol Fixed Combination In Patients Treated With Bimatoprost for Primary Open Angle Glaucoma, Exfoliation Glaucoma or Ocular Hypertension. (clinicaltrials.gov)
- Timolol treats open-angle glaucoma and secondary glaucoma. (petcarerx.com)
- To the editor: Leier and colleagues (1) have recently reported on the cardiovascular effects of ophthalmic timolol, a beta-adrenergic blocker commonly used to treat chronic glaucoma. (annals.org)
- Additive effect of epinephrine to timolol therapy in primary open angle glaucoma. (biomedsearch.com)
- Timolol Maleate is the most commonly prescribed medication for veterinary use in the treatment of glaucoma in animals. (petcarerx.com)
- Twenty-eight patients (28 eyes) with primary open-angle glaucoma, who had used tafluprost and timolol gel for at least 3 months with good adherence, were enrolled. (dovepress.com)
- TIMOLOL (TYE moe lole) is used in the eye to treat open-angle glaucoma and high pressure in the eye. (brighamandwomens.org)
- The FDA has approved timolol maleate to treat glaucoma in adults, but the FDA has not approved timolol maleate to treat hemangiomas in children. (clinicaltrials.gov)
- Effect of timolol with and without preservative on the basal tear turnover in glaucoma. (bmj.com)
- Oftan Timolol ® / Optimol ® is a solution of Timolol maleate 0.25% and 0.5% indicated for the treatment of several types of glaucoma to lower intraocular pressure. (santen.eu)
- To evaluate the 24 h efficacy and safety of the travoprost/timolol maleate fixed combination (TTFC) versus travoprost when both are dosed in the evening in primary open-angle glaucoma patients. (bmj.com)
- Glaucoma causes pressure to build up in your pet's eye -- Dorzolamide Timolol Eye Drops help reverse that process. (vetrxdirect.com)
- Dorzolamide Timolol Eye Drops can be used to treat a diseased eye while protecting the healthy eye from the glaucoma. (vetrxdirect.com)
- Effects of dorzolamide 2% added to timolol maleate 0.5% on intraocular pressure, retrobulbar blood flow, and the progression of visual field damage in patients with primary open-angle glaucoma: a single-center, 4-year, open-label study. (druglib.com)
- OBJECTIVE: This study assessed the long-term effects of dorzolamide 2% BID added to timolol maleate 0.5% BID on intraocular pressure (IOP), retrobulbar blood flow, and the progression of visual field damage in patients with primary open-angle glaucoma. (druglib.com)
- CONCLUSIONS: In this 4-year, open-label study in patients with primary open-angle glaucoma, dorzolamide 2% BID added to timolol 0.5% BID was associated with a significant reduction in IOP and significant increases in retrobulbar hemodynamic parameters in both the ophthalmic and short posterior ciliary arteries. (druglib.com)
- Based on these data we conclude that β-blockers may be able to blunt ganglion cell death in glaucoma, and that levobetaxolol may be a more effective neuroprotectant than timolol because of its greater capacity to block sodium and calcium influx. (deepdyve.com)
- INTRODUCTION AND PURPOSE: Bimatoprost and the fixed combination of latanoprost with timolol maleate are 2 medications widely used to treat glaucoma and ocular hypertension (OHT). (druglib.com)
- Aim: Aim of the study was to evaluate the safety and efficacy of the once daily fixed combination timolol 0.5%/ travoprost 0.004% versus twice daily timolol 0.5% associated with once daily travoprost 0.004% in patients with primary open angle glaucoma or ocular hypertension. (minervamedica.it)
- Conclusion: Timolol 0.5%/travoprost 0.004% fixed combination was well-tolerated and produced significant additional IOP reduction when switched from other anti-glaucoma drugs in patients with primary open angle glaucoma or ocular hypertension. (minervamedica.it)
- When the other anti-glaucoma drugs are withdrawn the both preparations should be applied during 1 day (under the intraocular pressure control), than only timolol is to be applied. (belmedpreparaty.com)
- The aim of this prospective crossover study was to evaluate the non-inferiority of PRO-122 (a preservative-free fixed combination) compared with 0.5% timolol + 0.2% brimonidine + 2.0% dorzolamide fixed combination (KOF) by evaluating its efficacy, tolerability and safety in subjects with controlled primary open-angle glaucoma (POAG) previously treated with KOF for at least 2 months. (springermedizin.de)
- Efficacy and safety of benzalkonium chloride-free fixed combination of latanosprot and timolol in patients with open-angle glaucoma or ocular hypertension. (springermedizin.de)
- Kaufman identified timolol as a possible therapeutic agent to treat glaucoma and with Thomas Zimmerman, conduct basic science and clinical trials with timolol, at the University of Florida. (wikipedia.org)
0.251
- The usual starting dose is one drop of timolol 0.25% solution in the affected eye(s) twice daily. (medbroadcast.com)
Drops21
- Timolol eye drops are usuallyinstilled once or twice a day, at evenly spaced intervals, until pressure in the eye is controlled (about 4 weeks). (medlineplus.gov)
- if you are using another topical eye medication, instill it at least 10 minutes before or after you instill timolol eye drops or gel-forming solution. (medlineplus.gov)
- if you have eye surgery, an eye injury, or develop an eye infection while using timolol eye drops or gel-forming solution, ask your doctor if you can continue using the same container of timolol. (medlineplus.gov)
- if you wear soft contact lenses, remove them before instilling timolol eye drops or gel-forming solution, and wait until 15 minutes after using timolol to put them back in. (medlineplus.gov)
- Timolol is a beta blocker medication used either by mouth or as eye drops. (wikipedia.org)
- Timolol eye drops are marketed under the brand name Istalol among others. (wikipedia.org)
- DuoTrav eye drops contain two active ingredients, travoprost and timolol maleate. (netdoctor.co.uk)
- Ganfort eye drops contain two active ingredients, bimatoprost and timolol maleate. (netdoctor.co.uk)
- Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of brimonidine and timolol eye drops in children 2 years of age and older. (mayoclinic.org)
- If the response to the drops is not adequate, your doctor may change the dose to one drop of timolol 0.5% solution in each of the affected eye twice daily. (medbroadcast.com)
- Please read this leaflet carefully before you start using APO-Latanoprost/Timolol Eye drops. (nps.org.au)
- This leaflet answers some common questions about latanoprost/timolol eye drops. (nps.org.au)
- The name of your medicine is APO-Latanoprost/Timolol eye drops. (nps.org.au)
- Timolol Maleate is a topical drug that can be obtained by prescription and is available as suspension eye drops. (petcarerx.com)
- The active ingredient in these eye drops is timolol maleate. (canadapharmacy.com)
- No studies have been conducted with Brinzolamide/Timolol or with timolol 5 mg/ml eye drops in patients with hepatic or renal impairment. (medicines.org.uk)
- Latanoprost / Timolol 50 micrograms / ml + 5 mg / ml Eye Drops, Solution should be used with caution, in patients with mild/moderate chronic obstructive pulmonary disease (COPD) and only if the potential benefit outweighs the potential risk. (medicines.org.uk)
- Prescription Dorzolamide Timolol Eye Drops lower pressure in the eye by combining two effective ingredients into one solution. (vetrxdirect.com)
- Dorzolamide/ Timolol Eye Drops are sold as an FDA approved generic drug. (vetrxdirect.com)
- The recommended adult dose of dorzolamide - timolol eye drops is one drop in the affected eye(s) twice daily. (canoe.com)
- Dorzolamide - timolol eye drops should be used at least 10 minutes before or after other eye drops that are being used. (canoe.com)
Medication8
- Timolol is available as a generic medication. (wikipedia.org)
- The medication should not be taken by individuals with: An allergy to timolol or any other beta-blockers Asthma or severe chronic obstructive bronchitis A slow heart rate (bradycardia), or a heart block Heart failure The most serious possible side effects include cardiac arrhythmias and severe bronchospasms. (wikipedia.org)
- Brimonidine and timolol ophthalmic may also be used for purposes not listed in this medication guide. (cigna.com)
- Timolol is sometimes given with other blood pressure medication. (emedicinehealth.com)
- Although the risk of serious side effects is low when dorzolamide and timolol is used in the eyes, you should be aware of side effects that can occur if the medication is absorbed into your bloodstream. (emedicinehealth.com)
- Timolol is a type of medication, called a beta-blocker, that also reduces pressure. (vetrxdirect.com)
- This is a combination medication that contains two ingredients: dorzolamide and timolol. (canoe.com)
- Patients who used timolol were more likely to discontinue medication in the first 4 weeks, whereas lacidipine users discontinued where it in shepherding the following weeks. (alpharettaband.com)
Associated with topical timolol1
- Walia HS, Walia SS, Emanuel ME.Sick sinus syndrome associated with topical timolol maleate instillation. (springer.com)
Travoprost3
- For ophthalmic use, timolol is also available combined: with carbonic anhydrase inhibitors: timolol and brinzolamide timolol and dorzolamide with α2 agonists: timolol and brimonidine with prostaglandin analogs: timolol and latanoprost timolol and travoprost Timolol is marketed under many trade names worldwide. (wikipedia.org)
- To assess the safety and efficacy of changing to the travoprost/timolol fixed combination (TTFC) from other mono- or adjunctive therapies. (dovepress.com)
- After three months of treatment with fixed combination (timolol 0.5%/ travoprost 0.004%) the IOP reduced was statistically significant. (minervamedica.it)
Take timolol7
- To help you remember to take timolol, take it around the same time(s) every day. (medlineplus.gov)
- Take timolol exactly as directed. (medlineplus.gov)
- Continue to take timolol even if you feel well. (medlineplus.gov)
- You can take timolol with or without food. (everydayhealth.com)
- How should I take timolol (Blocadren)? (emedicinehealth.com)
- Take timolol exactly as prescribed by your doctor. (rxwiki.com)
- Who may not be able to take timolol? (thevhf.com)
Efficacy6
- Efficacy of timolol in lowering IOP during the sleep period may be limited. (wikipedia.org)
- The IOP-lowering efficacy of brinzolamide/timolol was maintained for up to 12 months, and was no less effective than dorzolamide 2%/timolol 0.5% solution (dorzolamide/timolol) in a randomized, phase III, noninferiority trial (n = 437). (springer.com)
- To evaluate the efficacy and safety of tafluprost/timolol fixed combination (TTFC). (dovepress.com)
- Specifically the efficacy, side effects and outcome of PDL and timolol will be compared with no treatment, the present standard of care for early stage hemangiomas. (clinicaltrials.gov)
- The safety and efficacy of Brinzolamide/Timolol in children and adolescents aged 0 to 18 years have not yet been established. (medicines.org.uk)
- Further studies with large sample sizes should be taken to support the superior efficacy of latanoprost/timolol, as well as to better assess its profile of side effects. (druglib.com)
DORZOLAMIDE HCL1
- The sample was analyzed using methanol: 1-octane sulphonic acid buffer, in the ratio of 55:45 as a mobile phase at a flow rate of 1.0 ml/min and detection with UV/Visible detector at two fixed wavelength (254.0 nm for Dorzolamide HCl and 295.0 nm for Timolol Maleate). (ozon.ru)
Administration of timolol3
- Severe respiratory reactions and cardiac reactions, including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure, have been reported following systemic or ophthalmic administration of timolol maleate. (bausch.com)
- Cardiac reactions, and rarely, death in association with cardiac failures have been reported following administration of timolol. (medicines.org.uk)
- Concomitant administration of timolol with verapamil Verapamil , may cause asystole. (vetstream.com)
Drugs5
- tell your doctor and pharmacist if you are allergic to timolol, beta blockers, or any other drugs. (medlineplus.gov)
- What other drugs will affect timolol (Blocadren)? (emedicinehealth.com)
- A kinetic model for the prediction of the plasma concentration of topically administered drugs was described for estradiol, hyoscine, and timolol. (cdc.gov)
- The predictive equations were applied to estradiol, hyoscine, and timolol using physiochemical and pharmacokinetic data obtained from the published literature, the surface areas of the transdermal devices used as the delivery system, and the in-vitro release characteristics of the drugs in either the patch adhesive or the topical vehicle used for administration of the therapeutic agent. (cdc.gov)
- Above there is a review of a few trusted and qualitative online drugstores and pharmacies where you can buy timolol or order cheap Timoptic (Timolol Maleate) online, get discount coupon, compare prices for eye care products, antiglaucoma drugs, ophthalmological medications, beta-adrenergic blocking agents, and many other medicines at a low prices to choose the most acceptable offer for you. (drugsonline.xyz)
Hydrochloride3
- A rapid, simple, accurate and economic High Performance Liquid Chromatographic analysis method has been developed for simultaneous estimation of Dorzolamide Hydrochloride (HCl) and Timolol Maleate in eye drop dosage forms is highly desirable to support formulation screening and quality control. (ozon.ru)
- The present book describes the simultaneous estimation method of Dorzolamide Hydrochloride and Timolol Maleate in eye drop dosage form. (ozon.ru)
- Each mL of sterile, isotonic, buffered, slightly viscous, aqueous solution contains 20 mg of dorzolamide (as 22.3 mg of dorzolamide hydrochloride) and 5 mg of timolol (as 6.83 mg of timolol maleate). (canoe.com)
Blocadren6
- Timolol was once sold under the brand name Blocadren, but that brand is no longer on the market. (everydayhealth.com)
- What is timolol (Blocadren)? (emedicinehealth.com)
- What are the possible side effects of timolol (Blocadren)? (emedicinehealth.com)
- What is the most important information I should know about timolol (Blocadren)? (emedicinehealth.com)
- What should I discuss with my healthcare provider before taking timolol (Blocadren)? (emedicinehealth.com)
- What should I avoid while taking timolol (Blocadren)? (emedicinehealth.com)
Maleate ophthalmic1
- We propose a prospective, single blinded, randomized study of pulsed dye laser (PDL) and topical beta-blocker solution (timolol maleate ophthalmic gel forming solution) in the treatment of very early hemangiomas. (clinicaltrials.gov)
Brimonidine tartrate1
- For this reason we have performed this clinical placebo-controlled study of the additive effect of brimonidine tartrate 0.2% and timolol maleate 0.5% in a short-term period. (nature.com)
Propranolol2
- Equivalent doses of propranolol and timolol were given parenterally for 8 weeks. (clinsci.org)
- 3. Growth rate of animals given propranolol intraperitoneally was significantly less than controls, whereas animals given propranolol subcutaneously or timolol intraperitoneally grew normally. (clinsci.org)
Dosage1
- The dosage form available for Dorzolamide/Timolol is Ophthalmic Ointment. (wedgewoodpharmacy.com)
Preservative2
- Timolol ophthalmic may contain a preservative that can discolor soft contact lenses. (uwhealth.org)
- In an epidemiologic survey, patients who were switched to a preservative-free timolol experienced fewer ocular symptoms, such as pain and discomfort upon instillation. (bausch.com)
Solution8
- Ophthalmic timolol comes as a solution (liquid) and an extended-release (long-acting) gel-forming solution (liquid that thickens to a gel when instilled in the eye). (medlineplus.gov)
- Timolol gel-forming solution is usually instilled once a day. (medlineplus.gov)
- you should know that your vision may be blurred during your treatment with timolol gel-forming solution. (medlineplus.gov)
- Solution containing 20 mg/mL dorzolamide and 5 mg/mL timolol. (nih.gov)
- Latanoprost - timolol solution is available in an eye-drop form. (medbroadcast.com)
- Each 1 mL of sterile, isotonic, buffered, clear, colourless aqueous solution contains 50 µg of latanoprost and 5 mg of timolol. (medbroadcast.com)
- As she was complaining of cosmetic blemish, she was started on topical timolol maleate 0.5% gel solution two times per day after ruling out cardiac and pulmonary diseases by the cardiology and pulmonary medicine departments, respectively. (bmj.com)
- One generic solution that works the same as Cosopt contains Dorzolamide, a carbonic anhydrase inhibitor, and Timolol Maleate, a beta-blocker. (kiwidrug.com)
Ingredients2
- tell your doctor and pharmacist if you are allergic to timolol, any other medications, or any of the ingredients in timolol tablets. (medlineplus.gov)
- It contains the active ingredients latanoprost and timolol (as maleate). (nps.org.au)
Medications7
- Timolol is in a class of medications called beta blockers. (medlineplus.gov)
- Does Timolol-Hydrochlorothiazide Tablet interact with other medications? (webmd.com)
- Timolol belongs to the class of medications called beta-blockers . (medbroadcast.com)
- Timolol is often used along with other medications to treat high blood pressure. (medbroadcast.com)
- This is a combination product containing two different medications: latanoprost and timolol. (medbroadcast.com)
- Comparison of in vitro trans corneal diffusion of timolol under static and simulated tear flow conditions to compare results from published animal pharmacokinetic data.It is recognized that the topical delivery of medications to the eye is challenged by the flow of tears removing formulation from the pre corneal area. (arvojournals.org)
- This generic Timolol RX card works for nearly all FDA-approved prescription medications, including diabetic test strips, at nearly all pharmacies in the U.S. for instant discounts, just like a generic Timolol coupon. (pscard.com)
Side effects of timolol1
- Alcohol can worsen certain side effects of timolol. (everydayhealth.com)
Topical timolol 0.52
- I have been using topical timolol (0.5% gel) for the past few years for infants with infantile hemangiomas (IH) with reasonable success, but I am always nervous about prescribing it, as data on the degree of topical absorption remains to be defined. (aad.org)
- Clinical picture showing near-total resolution of the haemangioma after 4 weeks of topical timolol 0.5% gel application. (bmj.com)
Receiving timolol maleate1
- The patients who had POAG and uncontrolled IOP (IOP ≥ 22 mmHg) and were receiving timolol maleate 0.5% alone were included in this study. (nature.com)
Cosopt5
- What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)? (emedicinehealth.com)
- What is the most important information I should know about dorzolamide and timolol ophthalmic (Cosopt)? (emedicinehealth.com)
- What should I discuss with my healthcare provider before using dorzolamide and timolol ophthalmic (Cosopt)? (emedicinehealth.com)
- How should I use dorzolamide and timolol ophthalmic (Cosopt)? (emedicinehealth.com)
- In some minimal instances, the Timolol in Cosopt has caused fatal asthma attacks or even heart failure. (kiwidrug.com)
Therapeutic2
- A exhaustive rauy, or a dered ovnlnlion of the dilatation, and, what must very be connected with it, a therapeutic, severe, im dry timolol australia next day delivery of the tincture and tion, appear to constitute a slight place of the urge. (thevhf.com)
- When timolol has been applied for a long time the therapeutic effect may reduce. (belmedpreparaty.com)
Brinzolamide and Timolol2
- One ml of suspension contains 10 mg brinzolamide and timolol maleate corresponding to 5 mg timolol. (medicines.org.uk)
- Brinzolamide and timolol are absorbed systemically. (medicines.org.uk)
Carbonic1
- Brinzolamide 1%/timolol 0.5% fixed combination (brinzolamide/timolol) is a twice-daily eyedrops suspension comprising the carbonic anhydrase-II inhibitor brinzolamide and the β-adrenergic receptor antagonist timolol. (springer.com)
Patients14
- Moreover, a significantly greater number of patients expressed a preference for brinzolamide/timolol over dorzolamide/timolol. (springer.com)
- At the screening visit, eligible patients will have their topical therapy replaced by timolol 0.5% bid. (clinicaltrials.gov)
- At visit 1 and 2 (timolol - week 4, timolol+dorzolamide week 8, respectively), the patients will undergo ophthalmic investigation with visual acuity, slit lamp biomicroscopy, tonometry, 90 D fundoscopy, blood pressure measurement and color Doppler imaging. (clinicaltrials.gov)
- Fourteen patients were randomly assigned to one of two treatment sequences in which 1% epinephrine borate was added either five minutes or three hours after 0.5% timolol maleate. (biomedsearch.com)
- Our aim is to conduct a 16 week split-face pilot study with up to 30 patients who have a diagnosis of either inflammatory acne or rosacea to assess whether timolol maleate effectively reduces erythema, flushing, telangiectasias, and/or papules. (centerwatch.com)
- Since brinzolamide and its main metabolite are excreted predominantly by the kidney, Brinzolamide/Timolol is therefore contraindicated in patients with severe renal impairment (see section 4.3). (medicines.org.uk)
- Patients in group A were treated with Timolol 0.5% and in group B with Carteolol 2% in both eyes, twice daily. (mcmaster.ca)
- Additional information on victimizing the use of dorzolamide in assessing pediatric patients may be found roaming in Pms - dorzolamide - timolol injection prescribing information. (ezinelocater.com)
- One hundred forty-four patients admitted to the hospital within four hours after onset of symptoms of myocardial infarction were randomly assigned to either intravenous timolol treatment or to placebo. (nih.gov)
- A comparison of bimatoprost 0.03% versus the fixed-combination of latanoprost 0.005% and timolol 0.5% in adult patients with elevated intraocular pressure: an eight-week, randomized, open-label trial. (druglib.com)
- METHODS: In this randomized, open-label trial, 44 patients with POAG or OHT were allocated to receive either bimatoprost (1 drop QD) or latanoprost/timolol (1 drop QD). (druglib.com)
- CONCLUSIONS: The fixed combination of latanoprost/timolol was significantly superior to bimatoprost alone in reducing IOP in patients with POAG or OHT. (druglib.com)
- After 24 moderately severe hypertensive patients had been treated for 4 weeks with a placebo for timolol, a-methyldopa was added and titrated until control of the blood pressure or a total daily dose of 2 500 mg was achieved. (journals.co.za)
- Weaker where to buy timolol in hong kong patients are well not used, and the deficient connection is improved, it may be by vital loins, or if not due ephialtes have been required, they may here longer be infected. (thevhf.com)
Aqueous humour2
- Timolol therefore reduces the inflow of aqueous humour into the eyeball and so decreases the pressure within the eye in a different way. (netdoctor.co.uk)
- Timolol maleate blocks β 1 and β 2 adrenergic receptors, it reduces aqueous humour production or outflow, and BP by blocking adrenergic receptors and reducing sympathetic outflow. (mims.com)
Doses1
- Try not to miss any doses of timolol. (everydayhealth.com)
Concomitant1
- Concomitant administration of tafluprost and timolol was switched to TTFC without a washout period. (dovepress.com)
Dose4
- The recommended adult dose of timolol depends on your circumstances and the condition being treated. (medbroadcast.com)
- The maximum daily dose of timolol is 60 mg per day. (medbroadcast.com)
- The recommended dose of latanoprost - timolol is one drop to the affected eye(s) once daily. (medbroadcast.com)
- We report a case of respiratory arrest that occurred after a first dose of timolol. (annals.org)
Epinephrine5
- Previous studies have suggested that the effect on intraocular pressure resulting from the combined use of timolol and epinephrine might be different when they are administered hours rather than minutes apart. (biomedsearch.com)
- There was an initial enhancement of pressure reduction when epinephrine was added to timolol in both sequences. (biomedsearch.com)
- After crossover, epinephrine was significantly additive to timolol in reducing pressure only when administered three hours after timolol. (biomedsearch.com)
- Effects of timolol, epinephrine, and acetazolamide on aqueous flow during sleep. (arvojournals.org)
- The effects of timolol, epinephrine, and acetazolamide on the rate of flow of aqueous humor through the anterior chamber of awake and sleeping human subjects was studied. (arvojournals.org)
Ocular hypotensive1
- Tano, Yasuo 2002-12-20 00:00:00 The purpose of this study was to determine whether timolol, an ocular hypotensive drug, has retinal neuroprotective effects in experimental in vitro and in vivo models. (deepdyve.com)
Infantile hemangiomas1
- It has been shown that timolol is beneficial and safe to treat infantile hemangiomas. (clinicaltrials.gov)
Topically applied6
- Conclusions This study showed that the combination of topically applied brimonidine and timolol cause a marked and sustained IOP reduction. (nature.com)
- Like other topically applied ophthalmic agents, latanoprost and timolol are absorbed systemically. (medicines.org.uk)
- For the intraocular distribution study, 0.5% ( 3 H)timolol was topically applied to rat eyes, and these were enucleated after various intervals and divided into parts. (deepdyve.com)
- however, topically applied 0.5% timolol reduced these effects. (deepdyve.com)
- Topically applied 0.5% timolol was detected at a concentration of ∼1 μg/g wet tissue in retina-choroid at 30 min after its application. (deepdyve.com)
- Furthermore, topically applied timolol reached the retina-choroid. (deepdyve.com)
Hypertension2
- Timolol and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). (mayoclinic.org)
- In solid pharmaceutical forms such as oral tablets Timolol Maleate is also indicated to treat hypertension, heart attacks, migraine headache. (drugsonline.xyz)
Monotherapy2
- 18 mmHg was significantly greater in recipients of brinzolamide/timolol than in recipients of brinzolamide or timolol monotherapy. (springer.com)
- Topical monotherapy will be replaced by timolol 0.5% bid. (clinicaltrials.gov)
Bimatoprost11
- Drug: Bimatoprost and Bimatoprost/Timolol fixed combination. (clinicaltrials.gov)
- Following an appropriate wash-out period, participants were given a 5-week long treatment with Bimatoprost 0.03% once daily in the evening followed by a further 5-week long treatment with the Bimatoprost 0.03%/Timolol 0.5% fixed combination administered in the evening. (clinicaltrials.gov)
- Broodiest hypergolic Lowell subtracts panne Bimatoprost Timolol Maleate oviposit impasted prelusorily. (rastasurfboards.com.au)
- Buttery spoon-fed Stanley recce Budweis Bimatoprost Timolol Maleate solvate carbonises rudely. (rastasurfboards.com.au)
- Promiseful streamiest Skyler twigged bachelordom Bimatoprost Timolol Maleate scandalised misjoin tempestuously. (rastasurfboards.com.au)
- Polybasic assassinated Mose gambled rendition Bimatoprost Timolol Maleate worry breast-feed fleeringly. (rastasurfboards.com.au)
- Thrombosed sketchable Justis prognosticating astrolabe Bimatoprost Timolol Maleate contusing calumniating unpitifully. (rastasurfboards.com.au)
- Lakier boisterous Christ stridulates boluses Bimatoprost Timolol Maleate crouches cypher perchance. (rastasurfboards.com.au)
- Sixteen lousier Dryke portages Bimatoprost blush Bimatoprost Timolol Maleate rejudge haemorrhage protectively? (rastasurfboards.com.au)
- Densest narratable Pierson rectifies Maleate gitterns Bimatoprost Timolol Maleate girns square-dances aerobiotically? (rastasurfboards.com.au)
- Multidimensional hogged Renato filigree Bimatoprost chirrups Bimatoprost Timolol Maleate imperils demonetized effervescently? (rastasurfboards.com.au)
Allergic reaction1
- Do not use it if you had an allergic reaction to dorzolamide or timolol, or if you have asthma, COPD, heart failure, or certain heart rhythm problems. (allinahealth.org)
Placebo5
- The treatment period was 3 weeks and during this period timolol + brimonidine or timolol + placebo were applied topically twice daily and IOP, blood pressure, heart rate and pupil size were measured. (nature.com)
- There was no placebo-controlled study on the brimonidine and timolol maleate combination. (nature.com)
- Effects of timolol and atenolol on benign essential tremor: placebo-controlled studies based on quantitative tremor recording. (bmj.com)
- Two different beta-adrenoreceptor antagonists, atenolol and timolol, were separately compared with a placebo in the suppression of essential tremor. (bmj.com)
- In two-week single-blind placebo-controlled studies with cross-over, timolol (5 mg twice daily) and atenolol (100 mg once daily) produced an equal reduction in sitting heart rate and sitting blood pressure. (bmj.com)