Tumors or cancer of the THYROID GLAND.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
A benign epithelial tumor with a glandular organization.
A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).
Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
A multifunctional galactin initially discovered as a macrophage antigen that binds to IMMUNOGLOBULIN E, and as 29-35-kDa lectin that binds LAMININ. It is involved in a variety of biological events including interactions with galactose-containing glycoconjugates, cell proliferation, CELL DIFFERENTIATION, and APOPTOSIS.
Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.
Pathological processes involving the THYROID GLAND.
Surgical removal of the thyroid gland. (Dorland, 28th ed)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Blood tests used to evaluate the functioning of the thyroid gland.
Specific high affinity binding proteins for THYROID HORMONES in target cells. They are usually found in the nucleus and regulate DNA transcription. These receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively.
A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.
A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
A hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodination of many organic compounds, particularly proteins. EC 1.11.1.8.
High affinity receptors for THYROID HORMONES, especially TRIIODOTHYRONINE. These receptors are usually found in the nucleus where they regulate DNA transcription. They are encoded by the THRB gene (also known as NR1A2, THRB1, or ERBA2 gene) as several isoforms produced by alternative splicing. Mutations in the THRB gene cause THYROID HORMONE RESISTANCE SYNDROME.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).
Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.
A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
Neoplasms containing cyst-like formations or producing mucin or serum.
Inflammatory disease of the THYROID GLAND due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-CELLS and thyroid AUTOANTIBODIES. The clinical signs can range from HYPOTHYROIDISM to THYROTOXICOSIS depending on the type of autoimmune thyroiditis.
High affinity receptors for THYROID HORMONES, especially TRIIODOTHYRONINE. These receptors are usually found in the nucleus where they regulate DNA transcription. They are encoded by the THRA gene (also known as NR1A1, THRA1, ERBA or ERBA1 gene) as several isoforms produced by alternative splicing.
A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
An enlarged THYROID GLAND containing multiple nodules (THYROID NODULE), usually resulting from recurrent thyroid HYPERPLASIA and involution over many years to produce the irregular enlargement. Multinodular goiters may be nontoxic or may induce THYROTOXICOSIS.
Tumors or cancer of the SKIN.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
A dangerous life-threatening hypermetabolic condition characterized by high FEVER and dysfunction of the cardiovascular, the nervous, and the gastrointestinal systems.
Shortened forms of written words or phrases used for brevity.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
A neurosurgical procedure that removes the anterior TEMPORAL LOBE including the medial temporal structures of CEREBRAL CORTEX; AMYGDALA; HIPPOCAMPUS; and the adjacent PARAHIPPOCAMPAL GYRUS. This procedure is generally used for the treatment of intractable temporal epilepsy (EPILEPSY, TEMPORAL LOBE).
Fields representing the joint interplay of electric and magnetic forces.

Over-representation of a germline RET sequence variant in patients with sporadic medullary thyroid carcinoma and somatic RET codon 918 mutation. (1/4130)

The aetiology of sporadic medullary thyroid carcinoma is unknown. About 50% harbour a somatic mutation at codon 918 of RET (M918T). To investigate whether other RET sequence variants may be associated with or predispose to the development of sporadic medullary thyroid carcinoma, we analysed genomic DNA from the germline and corresponding tumour from 50 patients to identify RET sequence variants. In one patient, tumour DNA showed a novel somatic 12 bp in-frame deletion in exon 15. More interestingly, we found that the rare polymorphism at codon 836 (c.2439C > T; S836S) occurred at a significantly higher frequency than that in control individuals without sporadic medullary thyroid carcinoma (Fisher's exact test, P = 0.03). Further, among the nine evaluable cases with germline c.2439C/T, eight also had the somatic M918T mutation in MTC DNA which was more frequent than in patients with the more common c.2439C/C (89% vs 40%, respectively; Fisher's exact test, P = 0.01). These findings suggest that the rare sequence variant at codon 836 may somehow play a role in the genesis of sporadic medullary thyroid carcinoma.  (+info)

Medullary thyroid carcinoma with multiple hepatic metastases: treatment with transcatheter arterial embolization and percutaneous ethanol injection. (2/4130)

A 54-year-old man with medullary thyroid carcinoma in the thyroid gland was unable to undergo total thyroidectomy because the tumor had invaded the mediastinum. Radiation therapy and chemotherapy were given. Seven years later, intractable diarrhea and abdominal pain appeared, and computed tomography demonstrated hypervascular tumors in the thyroid gland and in the liver. The tumors were successfully treated with percutaneous ethanol injection to a lesion in the thyroid gland and transcatheter arterial embolization followed by percutaneous ethanol injection to tumors in the liver. Transcatheter arterial embolization and percutaneous ethanol injection may be valuable in treating medullary thyroid carcinoma.  (+info)

Epithelial thyroid tumors in cows. (3/4130)

From 1964 to 1973, 370 tumors were collected from cows of unknown age. Ten (2.7%) of these were primary thyroid tumors. Three were malignant. The benign tumors were solitary encapsulated adenomas in the parenchyma with more or less defined trabeculae, tubular, and microfollicular pattern. One of the malignant tumors was a cystic papillary adenocarcinoma, and two were small cell carcinomas consisting of small, sometimes binuclear, pleomorphic cells.  (+info)

Overexpression of fibroblast growth factor receptor 3 in a human thyroid carcinoma cell line results in overgrowth of the confluent cultures. (4/4130)

Recent reports indicate that a gain-of-function mutation in fibroblast growth factor receptor 3 (FGFR-3) inhibits cell growth in the cartilaginous growth plates. These results suggest that FGFR-3 may be the receptor transducing growth inhibitory signals. Using reverse transcription-PCR we examined seven papillary thyroid carcinomas to determine FGFR-3 expression. Six out of the seven papillary carcinomas expressed FGFR-3. To clarify the role of FGFR-3 in thyroid carcinoma, FGFR-3 was overexpressed in an established human papillary thyroid carcinoma cell line. High levels of FGFR-3 protein were identified in cells stably transfected with the vector containing FGFR-3 cDNA. The specific binding of 125I-FGF-2 of these cells was threefold higher than that of control cells. Growth rates of cells overexpressing FGFR-3 were similar to those of control cells. However, cells overexpressing FGFR-3 continued to grow beyond the density at which control cells stopped proliferating. These results suggest that FGFR-3 in thyroid carcinoma is not involved strongly in the cell proliferation mechanism but may contribute to the malignant extension of some of the carcinomas by modifying cell contact signaling.  (+info)

Psychosocial impact of genetic testing in familial medullary-thyroid carcinoma: a multicentric pilot-evaluation. (5/4130)

BACKGROUND: Many crucial problems are associated with the diagnosis of inherited cancer susceptibility. One of the most important is related to the psychosocial consequences of the knowledge by the patients and their relatives of their own genetical status. Little data are available in the literature, mainly from studies including small numbers of selected and motivated patients. PATIENTS AND METHODS: From January till December 1997, we studied the psychometric and quality of life parameters of 77 subjects followed in two French specialized centers. These subjects had been treated for either sporadic or familial or were at risk for medullary thyroid carcinoma. All patients had previously attended genetic counselling with detection of germline Ret-mutations, were informed on their own genetic risk, had good short-term prognosis and performance status and did not receive recent cancer treatment. Each patient was invited to answer two questionnaires, the hospital anxiety and depression scale (HADS) and the subjective quality of life profile (SQLP). RESULTS: We report herein the descriptive results of this study (HADS and SQLP scores and distributions) and describe the individual clinical covariates that might explain the observed differences between subgroups of individuals. Although psychometric scores appeared similar in these subgroups, quality of life scores were lower in Ret-mutation carriers. Genetically-predisposed patients were less satisfied and expressed more expectations for favourable change in their quality of life. CONCLUSION: This finding suggests a high level of frustration and latent unsatisfaction related either to the management of the genetic information given by the clinicians and its psychosocial consequences or simply to the knowledge of the genetic risk of cancer. Further studies on the individual consequences of genetic testing, information delivery and when necessary psychotherapeutic interventions, are needed to insure the quality of presymptomatic genetic testing in this field of oncology.  (+info)

A new rapid technique for the fixation of thyroid gland surgical specimens. (6/4130)

One of the main diagnostic problems in thyroid pathology is to distinguish between follicular adenoma and follicular carcinoma. Thorough sampling of the nodule's capsule is recommended in order to identify capsular invasion. However, during the hardening of the tissue, by the usual fixatives the capsule shrinks and rolls downwards and sometimes the capsule separates from the remaining tissue. The present work evaluates the use of "Lymph Node Revealing Solution" (LNRS) for the rapid fixation (2h) of different thyroid lesions as compared to that of formalin. Fifty-one unselected consecutive cases of thyroid nodules, which included various benign and malignant lesions, were examined. Each specimen was cut in two equal parts; one was fixed in LNRS, the other in formalin. Fixation in LNRS for 2 hours gave adequate results in sectioning and staining of the tissue, and excellent immunostains. Its advantage over formalin is the conservation of the natural relationship between the capsule and the rest of the tissue, on the same plane, as well as the short time required for the final diagnosis.  (+info)

Overexpression of c-Ras in hyperplasia and adenomas of the feline thyroid gland: an immunohistochemical analysis of 34 cases. (7/4130)

Formalin-fixed, paraffin-embedded thyroid glands from 18 cats diagnosed with hyperthyroidism were evaluated immunohistochemically for overexpression of the products of oncogenes c-ras and bcl2 and the tumor suppressor gene p53. Fourteen thyroid glands from euthyroid cats without histologically detectable thyroid lesions were examined similarly as controls. Results from these investigations showed that all cases of nodular follicular hyperplasia/adenomas stained positively for overexpression of c-Ras protein using a mouse monoclonal anti-human pan-Ras antibody. The most intensely positively staining regions were in luminal cells surrounding abortive follicles. Subjacent thyroid and parathyroid glands from euthyroid cats did not stain immunohistochemically for pan-Ras. There was no detectable staining for either Bc12 or p53 in any of the cats. These results indicated that overexpression of c-ras was highly associated with areas of nodular follicular hyperplasia/adenomas of feline thyroid glands, and mutations in this oncogene may play a role in the etiopathogenesis of hyperthyroidism in cats.  (+info)

Human thyroid cancer cells as a source of iso-genic, iso-phenotypic cell lines with or without functional p53. (8/4130)

Differentiated thyroid carcinomas (in contrast to the rarer anaplastic form) are unusual among human cancers in displaying a remarkably low frequency of p53 mutation and appear to retain wild-type (wt) p53 function as assessed by the response of derived cell lines to DNA damage. Using one such cell line, K1, we have tested the effect of experimental abrogation of p53 function by generating matched sub-clones stably expressing either a neo control gene, a dominant-negative mutant p53 (143ala) or human papilloma virus protein HPV16 E6. Loss of p53 function in the latter two groups was confirmed by abolition of p53-dependent 'stress' responses including induction of the cyclin/CDK inhibitor p21WAF1 and G1/S arrest following DNA-damage. In contrast, no change was detected in the phenotype of 'unstressed' clones, with respect to any of the following parameters: proliferation rate in monolayer, serum-dependence for proliferation or survival, tumorigenicity, cellular morphology, or tissue-specific differentiation markers. The K1 line therefore represents a 'neutral' background with respect to p53 function, permitting the derivation of functionally p53 + or - clones which are not only iso-genic but also iso-phenotypic. Such a panel should be an ideal tool with which to test the p53-dependence of cellular stress responses, particularly the sensitivity to potential therapeutic agents, free from the confounding additional phenotypic differences which usually accompany loss of p53 function. The results also further support the hypothesis that p53 mutation alone is not sufficient to drive progression of thyroid cancer to the aggressive anaplastic form.  (+info)

TY - JOUR. T1 - Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray. AU - Gol Choe, Jae. AU - Kim, Yu Ri. AU - Kim, Ki Nam. AU - Choo, Hyo Jung. AU - Shin, Jae Hoon. AU - Lee, Yong Jin. AU - Chung, June Key. AU - Kim, Meyoung Kon. PY - 2005/12. Y1 - 2005/12. N2 - The sodium/iodide symporter (NIS) is a membrane glycoprotein that mediates active I uptake during the treatment of cancer of the thyroid gland and extrathyroidal tissues. NIS gene transfection, a gene-therapy modality, has been introduced in many types of cancer, such as prostate cancer and breast cancer, and has demonstrated a high potential for the treatment of non-thyroidal cancers. To investigate the pattern of NIS gene expression and provide evidence of its beneficial effects in human anaplastic cancer ARO cells by using a radioactive complementary DNA (cDNA) microarray.. AB - The sodium/iodide symporter ...
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was previously classified as an encapsulated follicular variant of papillary thyroid carcinoma, necessitating a new classification as it was recognized that encapsulated tumors without invasion have an indolent behavior, and may be over-treated if classified as a type of cancer. Definition of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A noninvasive neoplasm that arises from the thyroid follicular cells (cells that normally make thyroid hormone), showing a predominantly follicular growth pattern and with nuclear features of papillary thyroid carcinoma. There are several specific inclusion and exclusion criteria (see below). When these are met, this tumor has an extremely low malignant potential. Abbreviations: NIFTP: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features EFVPTC: Encapsulated follicular variant of ...
TY - JOUR. T1 - Comprehensive genetic characterization of human thyroid cancer cell lines. T2 - A validated panel for preclinical studies. AU - Landa, Iñigo. AU - Pozdeyev, Nikita. AU - Korch, Christopher. AU - Marlow, Laura A.. AU - Smallridge, Robert Christian. AU - Copland, John A III. AU - Henderson, Ying C.. AU - Lai, Stephen Y.. AU - Clayman, Gary L.. AU - Onoda, Naoyoshi. AU - Tan, Aik Choon. AU - Garcia-Rendueles, Maria E.R.. AU - Knauf, Jeffrey A.. AU - Haugen, Bryan R.. AU - Fagin, James A.. AU - Schweppe, Rebecca E.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Purpose: Thyroid cancer cell lines are valuable models but have been neglected in pancancer genomic studies. Moreover, their misidentification has been a significant problem. We aim to provide a validated dataset for thyroid cancer researchers. Experimental Design: We performed next-generation sequencing (NGS) and analyzed the transcriptome of 60 authenticated thyroid cell lines and compared our findings with the known genomic defects ...
TY - JOUR. T1 - Sonographic findings predictive of central lymph node metastasis in patients with papillary thyroid carcinoma. T2 - Influence of associated chronic lymphocytic thyroiditis on the diagnostic performance of sonography. AU - Yoo, Yeon Hwa. AU - Kim, Jeong Ah. AU - Son, Eun Ju. AU - Youk, Ji Hyun. AU - Kwak, Jin Young. AU - Kim, Eun Kyung. AU - Park, Cheong Soo. PY - 2013/12/1. Y1 - 2013/12/1. N2 - Objectives-To analyze sonographic findings suggesting central lymph node metastasis of papillary thyroid carcinoma and to evaluate the influence of associated chronic lymphocytic thyroiditis on the diagnostic performance of sonography for predicting central lymph node metastasis. Methods-A total of 124 patients (101 female and 23 male; mean age, 47.5 years; range, 21-74 years) underwent sonographically guided fine-needle aspiration in central lymph nodes from January 2008 to July 2011. Sonographic features of size, shape, margin, thickening of the cortex, cortical echogenicity, presence of ...
Mutation of the BRAF gene is common in thyroid cancer. Follicular variant of papillary thyroid carcinoma is a variant of papillary thyroid carcinoma that has created continuous diagnostic controversies among pathologists. The aims of this study are to (1) investigate whether follicular variant of papillary thyroid carcinoma has a different pattern of BRAF mutation than conventional papillary thyroid carcinoma in a large cohort of patients with typical features of follicular variant of papillary thyroid carcinoma and (2) to study the relationship of clinicopathological features of papillary thyroid carcinomas with BRAF mutation. Tissue blocks from 76 patients with diagnostic features of papillary thyroid carcinomas (40 with conventional type and 36 with follicular variant) were included in the study. From these, DNA was extracted and BRAF V600E mutations were detected by polymerase chain reaction followed by restriction enzyme digestion and sequencing of exon 15. Analysis of the data indicated ...
Anaplastic thyroid carcinoma, which is one of the most aggressive, malignant tumors in humans, results in an extremely poor prognosis despite chemotherapy and radiotherapy. The present study was designed to evaluate therapeutic effects of radiation by glycerol on p53-mutant anaplastic thyroid carcinoma cells (8305c cells). To examine the effectiveness of glycerol in radiation induced lethality for anaplastic thyroid carcinoma 8305c cells, we performed colony formation assay and apoptosis analysis. Apoptosis was analyzed with Hoechst 33342 staining and DNA ladder formation assay. 8305c cells became radiosensitive when glycerol was added to culture medium before X-ray irradiation. Apoptosis was induced by X-rays in the presence of glycerol. However, there was little apoptosis induced by X-ray irradiation or glycerol alone. The binding activity of whole cell extracts to bax promoter region was induced by X-rays in the presence of glycerol but not by X-rays alone. These findings suggest that glycerol is
TY - JOUR. T1 - Involvement of cysteine-rich protein 61 in the epidermal growth factor-induced migration of human anaplastic thyroid cancer cells. AU - Chin, Li Han. AU - Hsu, Sung Po. AU - Zhong, Wen-Bin. AU - Liang, Yu Chih. PY - 2016. Y1 - 2016. N2 - Anaplastic thyroid cancer (ATC) is among the most aggressive types of malignant cancer. Epidermal growth factor (EGF) plays a crucial role in the pathogenesis of ATC, and patients with thyroid carcinoma typically exhibit increased cysteine-rich protein 61 (Cyr61). In this study, we found that EGF treatment induced cell migration, stress fiber formation, Cyr61 mRNA and protein expressions, and Cyr61 protein secretion in ATC cells. The recombinant Cyr61 protein significantly induced cell migration; however, inhibition of Cyr61 activity by a Cyr61-specific antibody abrogated EGF-induced cell migration. EGF treatment also affected epithelial-to-mesenchymal transition (EMT)-related marker protein expression, as evidenced by an increase in vimentin and ...
An individual with 2 first-degree relatives who have or have had non-medullary thyroid cancer or a documented diagnosis of non-medullary thyroid cancer and one living relative with documented non-medullary thyroid cancer. (Note: as this is a familial study, subjects do not need to present with the disease.). OR. Any member of an affected family. (Note: for this study, an affected family is defined as a family having 2 or more 1st degree relatives with a documented diagnosis of FNMTC.). ...
While cancer can be a terrifying word, the most common kinds of thyroid cancer often have a good prognosis. There are five kinds of thyroid cancer: papillary thyroid cancer, follicular thyroid cancer, Hurthle cell cancer, medullary thyroid cancer, and anaplastic thyroid cancer. The most common form of thyroid cancer is papillary thyroid cancer which represents about 85% of all thyroid cancers. Papillary thyroid cancer generally carries a good prognosis. Follicular thyroid and Hurthle cell cancer represent about 10% of all thyroid cancers. Medullary and Anaplastic thyroid cancers are much more rare making up ,5% of all thyroid cancers.. Treatment for thyroid cancer requires the surgical removal of the thyroid cancer and sometimes the whole thyroid gland. Associated lymph nodes may also be removed if indicated. Approximately 8 weeks after the thyroid removal some patients will receive radioactive iodine if it is indicated. Thyroid replacement hormone will now be needed for life. If you have been ...
Department of Internal Medicine 4, Saitama Medical School, 38 Morohongo, Moroyama, Iruma-gun, Saitama 350-0495, Japan. Zinc at concentrations of 150, microM or higher induced necrosis as well as apoptosis in thyroid cancer cell lines. Necrosis was induced by zinc in a dose-dependent manner, whereas apoptosis did not increase at higher concentrations of zinc. The expression of the antiapoptotic protein phosphorylated Bad was markedly increased, whereas the expression of the proapoptotic proteins Bax and Bad decreased following Zn(2+) exposure. Zn(2+) induced rapid degradation of IkappaB, and an increase in the binding of nuclear transcription factor-kappaB (NF-kappaB). These observations indicate that antiapoptotic pathways were activated in thyroid cancer cells following exposure to Zn(2+). This may be a self-defence mechanism against apoptosis and may underlie the general resistance of thyroid cancer cells to apoptotic stimuli. Zinc may be a potential cytotoxic agent for the treatment of ...
|i|Background.|/i| Papillary thyroid carcinoma (PTC) is a form of thyroid cancer with high risk of cervical lymph node metastasis. |i|Aim.|/i| The aim of this study was to investigate the incidence and the predictive factors for occult ipsilateral central lymph node (CLN) metastasis in the patients with papillary thyroid carcinoma. |i|Methods.|/i| A total of 916 PTC patients (1017 lesions) undergoing central lymph node dissection in our hospital from 2005 to 2011 were enrolled. The relationship between CLN metastasis and clinical factors such as gender, age, tumor size, tumor number, capsule invasion, and tumor location was analyzed. |i|Results.|/i| Occult CLN metastasis was observed in 52.41% (533/1017) of PTC lesions, respectively. Multivariate analysis showed that age ≤ 35 years, tumor size > 1.5 cm, present capsule invasion/extracapsular invasion, and tumor located in upper/middle pole/whole lobe were risk factors of CLN metastasis. |i|Conclusions.|/i| Tumor located in upper
Anaplastic thyroid carcinoma is fatal if unresectable. However, improved survival has been reported after gross total resection and multimodality therapy. In this report, we describe the contrast-enhanced high-resolution CT characteristics of anaplastic thyroid carcinoma in 57 patients. Anaplastic thyroid carcinoma presented as a large neck mass with necrosis in 82% of cases. The tumors demonstrated common extrathyroidal extension (91%). Sixty-two percent of tumors demonstrated calcification. Visceral space invasion involved the esophagus (62%), trachea (57%), and larynx (29%). Carotid artery encasement was present in 42%, and 43% involved the internal jugular vein. Sixty-three percent had lateral compartment lymphadenopathy; 58% of these nodes were necrotic, and 11% were cystic. No metastatic nodes had calcification. Central compartment lymphadenopathy was seen in 56% of cases, and lateral retropharyngeal lymphadenopathy was detected in 12%. Knowledge of these imaging features aids in guiding ...
Introduction: We report an unusual case of adenocarcinoma of lung metachronous with stage IVA papillary thyroid carcinoma. The two tumors are morphologically similar; and the later presence of lung mass could clinically masquerade as metastatic thyroid carcinoma. We discuss the challenges in clinical, imaging and pathologic diagnosis. Case Report: A 64-year-old non-smoking female had a thyroidectomy and neck lymph node dissection for a stage IVA tumor with pathologic findings of one 2 mm microcarcinoma of left thyroid and six positive cervical lymph nodes. The post-surgical I131 whole body scan was negative and thyroglobulin is suppressed and stable (
Rapid progression contributes to treatment failure in anaplastic thyroid carcinoma (ATC) patients. In a preliminary study, we demonstrated that some hematopoietic factors may be involved in the progression of ATC. The adaptor protein LNK, which is a negative regulator of hematopoietic cytokine signalling, has been studied extensively in malignant hematopoietic cells. However, there are few studies on LNK in solid tumours. Real-time PCR, immunohistochemistry (IHC) and western blot analysis of LNK were performed on ATC cells, differentiated thyroid cancer (DTC) cells and normal thyroid cells. In vitro assays (including pull-down, liquid chromatography-mass spectrometry (LC-MS), co-IP, MTT and colony formation) were performed to validate the effect of LNK on ATC progression and elucidate the molecular mechanisms. Compared with DTC cells and normal thyroid cells, ATC cells exhibit overexpression of LNK. In addition, LNK overexpression results in increased proliferation of ATC cells. Conversely, LNK
A collision tumor involving a tracheal sarcomatoid carcinoma and a papillary thyroid carcinoma has never been reported in the literature. A 78-year-old female presented with a large neck mass and hoarseness. A fine needle aspiration demonstrated papillary thyroid carcinoma. Imaging revealed a right thyroid mass invading into the tracheal lumen with bulky ipsilateral lymphadenopathy. The patient underwent a total thyroidectomy, tracheal resection, and central and right neck dissections. Pathology demonstrated a tracheal sarcomatoid carcinoma invading the right thyroid, which had multifocal papillary thyroid carcinoma with central and lateral neck metastases. The patient subsequently received adjuvant chemoradiotherapy and radioactive iodine. We present a case of a tracheal sarcomatoid carcinoma colliding with a papillary thyroid cancer. Treatment modalities should address the most aggressive tumor, while being tailored to clinical picture, tumor histology, and patient preferences.
Introduction: The commonest metastases to the thyroid are from renal cell carcinomas (RCC) and 23 48% of all thyroid metastases are RCCs. They may occur many years after RCC excision, the longest reported latent period being 20 years. Sunitinib (SUN), a multiple targeted anti-cancer drug, is increasingly used for RCC therapy but may cause thyroid dysfunction in some usually hypothyroidism. We report a patient who presented with thyroid metastases 21 years after RCC excision, who developed biphasic thyroid dysfunction during SUN therapy.. Case presentation: A 76-year-old woman who had a nephrectomy for RCC 21 years before, and was on no relevant medication, presented with an enlarging right thyroid nodule. She had a thyroid lobectomy following inadequate FNAC of the nodule. Histology revealed metastatic clear cell renal carcinoma. CT scans revealed possible pancreatic and ovarian metastases but no recurrence at the original site. She was started on SUN for disseminated disease, after ...
Persistent RET activation is a frequent event in papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC). In these cancers, RET activates the ERK/MAPK, the PI3K/AKT/mTOR and the JAK/STAT3 pathways. Here, we tested the efficacy of a JAK1/2- inhibitor, AZD1480, in the in vitro and in vivo growth of thyroid cancer cell lines expressing oncogenic RET. Thyroid cancer cell lines harboring RET/PTC1 (TPC-1), RET M918T (MZ-CRC1) and RET C634W (TT) alterations, as well as TPC-1 xenografts, were treated with JAK inhibitor, AZD1480. This inhibitor led to growth inhibition and/or apoptosis of the thyroid cancer cell lines in vitro, as well as to tumor regression of TPC-1 xenografts, where it efficiently blocked STAT3 activation in tumor and stromal cells. This inhibition was associated with decreased proliferation, decreased blood vessel density, coupled with increased necrosis. However, AZD1480 repressed the growth of STAT3- deficient TPC-1 cells in vitro and in vivo, demonstrating that its effects
OBJECTIVE: The role of routine central lymph node dissection (CLND) for clinically central lymph node negative (CN0) papillary thyroid microcarcinoma (PTMC) remains uncertain. We aim to determine the predictive factors for central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma. PATIENTS AND METHODS: A total of 273 patients diagnosed with clinically central lymph node negative PTMC from 2014 to 2016 were included. The predictive risk factors for CLNM were analyzed with respect to age, sex, tumor size, tumor multifocal, lymphadenectasis of lateral neck, capsular invasion, extra capsular spread (ECS), coexistence of chronic lymphocytic thyroiditis (Hashimoto thyroiditis, HT) and nodular goiter (NG), BRAFV600E mutation and subtype of papillary thyroid carcinoma (PTC ...
Studies on genetic susceptibility for thyroid cancer could have important relevance to understand the etiology of this pathology. Thus, association studies aimed to identify genes for thyroid cancer risk have been recently published (9-12), although no specific genes for thyroid cancer susceptibility have yet been described. Our previous study, using the BAT-40 marker in a case-control study, indicated that the chromosome 1p12-13 is related to thyroid cancer susceptibility (13). Therefore, in the present study, we aimed to map the susceptibility loci on this region. In this context, we have scanned a region of ∼2.4 Mb surrounding the BAT-40 marker by genotyping six single-nucleotide polymorphisms in a Spanish population. This study has allowed us to identify in our population two independent genetic susceptibility loci on chromosome 1p12.. Association analysis using a case-control design showed a strong association between the rs2145418 marker and thyroid cancer incidence, and similar results ...
TY - JOUR. T1 - PD-1 Blockade in Anaplastic Thyroid Carcinoma. AU - Capdevila, Jaume. AU - Wirth, Lori J.. AU - Ernst, Thomas. AU - Ponce Aix, Santiago. AU - Lin, Chia Chi. AU - Ramlau, Rodryg. AU - Butler, Marcus O.. AU - Delord, Jean Pierre. AU - Gelderblom, Hans. AU - Ascierto, Paolo A.. AU - Fasolo, Angelica. AU - Führer, Dagmar. AU - Hütter-Krönke, Marie Luise. AU - Forde, Patrick M.. AU - Wrona, Anna. AU - Santoro, Armando. AU - Sadow, Peter M.. AU - Szpakowski, Sebastian. AU - Wu, Hongqian. AU - Bostel, Geraldine. AU - Faris, Jason. AU - Cameron, Scott. AU - Varga, Andreea. AU - Taylor, Matthew. PY - 2020/8/10. Y1 - 2020/8/10. N2 - PURPOSE: Anaplastic thyroid carcinoma is an aggressive malignancy that is almost always fatal and lacks effective systemic treatment options for patients with BRAF-wild type disease. As part of a phase I/II study in patients with advanced/metastatic solid tumors, patients with anaplastic thyroid carcinoma were treated with spartalizumab, a humanized ...
The incidence of thyroid cancer, the most common endocrine malignancy, continues to increase steadily during the past few decades worldwide [1, 2]. The majority of thyroid cancer types are classified as: follicular epithelial cell-derived papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), anaplastic thyroid cancer (ATC), and para-follicular C-cell derived medullary thyroid cancer (MTC) [3]. The prognosis of patients with thyroid cancer is closely correlated with local invasion outside the thyroid capsule and the development of distant metastases [4]. Therefore, dissecting the molecular mechanisms underlying thyroid cancer invasion and metastasis is still imperative and may put new insight into the clinical treatment of thyroid cancer.. Human tumor-associated calcium signal transducer 2 (TACSTD2), also known as trophoblast cell-surface antigen 2 (Trop2), is a type I transmembrane glycoprotein originally identified in human placental trophoblastic tissue [5]. As a cell surface ...
TY - JOUR. T1 - New therapeutic options for advanced forms of thyroid cancer. AU - Bernet, Victor. AU - Smallridge, Robert. PY - 2014/6. Y1 - 2014/6. N2 - Introduction: While the vast majority of patients with thyroid cancer have an excellent prognosis, those with more aggressive courses experience significant morbidity and mortality. Advanced forms of thyroid cancer are typically refractory to standard therapy. Numerous agents with potential usefulness in the treatment of advanced thyroid cancer have recently come under study. Areas covered: This article reviews agents identified through a systematic review of the scientific literature as being under investigation for treatment of advanced thyroid cancer. A search of both PubMed and the NCI Clinical Trials website was performed to identify such agents having reached Phase II or III testing. Improved understanding of cancer cell signaling pathways has led to the identification of , 500 kinases as potential therapeutic targets. Additional agents ...
The survival rate of anaplastic thyroid cancer (ATC) is still very poor due to its fast growth and high metastatic potential. Currently, no effective treatment is available. The active form of vitamin D3, 1α,25(OH)2D3, has been shown to have a anti-metastatic effect in pre-clinical studies, however induction of hypercalcemia hampered its clinical application. The new class of less-calcemic vitamin D analog, 19-nor-2α-(3-hydroxypropyl)-1α,25-dihydroxyvitamin D3 (MART-10), is much more potent than 1α,25(OH)2D3 to repress cancer growth and metastasis in a variety of cancers. In this study, we demonstrated that both 1α,25(OH)2D3 and MART-10 could effectively inhibit the migration and invasion of ATC cells, 8305C and 8505C, with MART-10 much more potent than 1α,25(OH)2D3. The anti-metastatic effect of 1α,25(OH)2D3 and MART-10 on ATC cells is mediated by reversal of cadherin switch (upregulation of E-cadherin and downregulation of N-cadherin), which led to the attenuation of EMT process, and decrease
A comprehensive analysis of MNG1, TCO1, fPTC, PTEN, TSHR, and TRKA in familial nonmedullary thyroid cancer: Confirmation of linkage to TCO1. About 5% of nonmedullary thyroid cancer is familial. These familial nonmedullary thyroid cancer cases are characterized by an earlier age of onset, more aggressive phenotype, and in some families a high propensity to benign thyroid disease. Little is known about the genes conferring predisposition to nonmedullary thyroid cancer. Three loci have been identified through genetic linkage: MNG1 on 14q32, TCO1 on 19p13.2, and fPTC on 1p21. In addition to these putative genes, a number of loci represent candidate familial nonmedullary thyroid cancer predisposition genes by virtue of their involvement in sporadic disease (TRKA), their role in benign disease (TSHR), and because they underlie syndromes with a risk of nonmedullary thyroid cancer (PTEN). To evaluate the roles of MNG1, TCO1, fPTC, PTEN, TSHR, and TRKA in familial nonmedullary thyroid cancer, we have ...
TY - JOUR. T1 - Tumor immune microenvironment characteristics of papillary thyroid carcinoma are associated with histopathological aggressiveness and BRAF mutation status. AU - Means, Casey. AU - Clayburgh, Daniel. AU - Maloney, Lauren. AU - Sauer, David. AU - Taylor, Matthew H.. AU - Shindo, Maisie. AU - Coussens, Lisa. AU - Tsujikawa, Takahiro. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background: Papillary thyroid carcinoma (PTC) follows an indolent course; however, up to 30% of patients develop recurrent disease requiring further treatment. Profiling PTC immune complexity may provide new biomarkers for improved risk prediction. Methods: Immune complexity profiles were quantitatively evaluated by multiplex immunohistochemistry (mIHC) in archived tissue sections from 39 patients with PTC, and were assessed for correlations with aggressive histopathological features based on the presence of lymphovascular invasion and/or extrathyroidal extension, and BRAF V600E mutational status. Results: mIHC ...
Sorafenib (Nexavar), is a multikinase inhibitor, which has demonstrated both antiproliferative and antiangiogenic properties in vitro and in vivo, inhibiting the activity of targets present in the tumoral cells (c-RAF [proto-oncogene serine/threonine-protein kinase], BRAF, (V600E)BRAF, c-KIT, and FMS-like tyrosine kinase 3) and in tumor vessels (c-RAF, vascular endothelial growth factor receptor [VEGFR]-2, VEGFR-3, and platelet-derived growth factor receptor β). Sorafenib was initially approved for the treatment of hepatocellular carcinoma and advanced renal cell carcinoma. Experimental studies have demonstrated that sorafenib has both antiproliferative and antiangiogenic properties in vitro and in vivo, against thyroid cancer cells. Furthermore, several completed (or ongoing) studies have evaluated the long-term efficacy and tolerability of sorafenib in patients with papillary, follicular and medullary aggressive thyroid cancer. The results of the different studies showed good clinical ...
Inclusion Criteria: - Histologically confirmed locally advanced or metastatic thyroid cancer - Measurable disease - Normal blood pressure (if history of hypertension, blood pressure must be controlled with medication) - Evidence of disease progression within 6 months before starting study (for differentiated thyroid cancer subjects) - Evidence of disease progression within 6 months before starting study OR symptomatic disease (for medullary thyroid cancer subjects) - Not a candidate for surgical resection, external beam radiotherapy, radioiodine therapy, or other local therapy - At least 18 years of age Exclusion Criteria: - Undifferentiated/anaplastic thyroid cancer - Untreated or symptomatic brain metastases - Prior malignancy, unless cured with treatment and no evidence of disease for greater than or equal to 3 years before starting study (history of thyroid cancer, in situ cervical cancer, or basal cell cancer of skin are exceptions) - Myocardial infarction or any unstable cardiac condition ...
Objective: To assess predictors of well-differentiated thyroid cancer (WDTC) persistence/recurrence. Design: This was a retrospective chart review of thyroid carcinoma patients seen 1979-2007 in a Boston, Massachusetts-area multispecialty group. Of 1,025 patients, 431 met eligibility criteria. Cox proportional hazards models were used to assess predictors (gender, age, ethnicity, tumor size, surgical histology) of WDTC persistence/recurrence (elevated thyroglobulin levels with negative thyroglobulin-antibodies; or positive imaging). Local extension of disease and lymph node involvement could not be assessed. Results: Mean age at initial surgery (n = 431, 74% women, 79% Caucasian) was 45.8 \(\pm\) 13.5(SD) years. Mean tumor (papillary, 91%; follicular, 5%; Hurthle cell, 2%; \(\ge\)1 type, 2%) size was 2.5 \(\pm\) 1.6(SD) cm. Most tumors were unifocal (57%) and \(\ge\)1 cm (89%). Over 2,600 person-years of follow-up, persistence/recurrence occurred in 52 patients (12%) 4.3 years (median; range ...
Thyroid cancer, the commonest of endocrine malignancies, continues increasing in incidence being the 5th more prevalent cancer among women in the United States in 2012. Familial thyroid cancer has become a well-recognized, unique, clinical entity in patients with thyroid cancer originating from follicular cells, that is, nonmedullary thyroid carcinoma. Hereditary nonmedullary thyroid cancer may occur as a minor component of familial cancer syndromes (familial adenomatous polyposis, Gardners...
Wee1 is a kinase that regulates the G2/M progression by the inhibition of CDK1, which is critical for ensuring DNA damage repair before initiation of mitotic entry. Targeting Wee1 may be a potential strategy in the treatment of anaplastic thyroid cancer, a rare but lethal disease. The therapeutic effects of adavosertib, a Wee1 inhibitor for anaplastic thyroid cancer was evaluated in this study. Adavosertib inhibited cell growth in three anaplastic thyroid cancer cell lines in a dose-dependent manner. Cell cycle analysis revealed cells were accumulated in the G2/M phase. Adavosertib induced caspase-3 activity and led to apoptosis. Adavosertib monotherapy showed significant retardation of the growth of two anaplastic thyroid cancer tumor models. The combination of adavosertib with dabrafenib and trametinib revealed strong synergism in vitro and demonstrated robust suppression of tumor growth in vivo in anaplastic thyroid cancer xenograft models with BRAF V600E mutation. The combination of ...
The study objective is to analyze the mutation profile of the tall cell variant (TCV) of papillary thyroid carcinoma (PTC). Materials and methods. The main inclusion criteria according to the WHO classification (2017) was PTC composed of at least 30 % of tall cells. Genetic examination was conducted using the FoundationOne CDx assay (USA) with median depth of coverage of |500x. This study included 5 patients (1 man and 4 women) with a mean age of 52.6 years (range: 48-56 years). The tumor size varied between 0.4 x 0.5 cm and 11.0 x 9.0 cm. All patients have undergone surgical treatment: hemithyroidectomy for patient No. 1 with a small tumor (pT1b); thyroidectomy for patient No. 2 (pT3b); extensive thyroidectomy with the removal of paratracheal tissue for patients No. 3, 4, and 5 (No. 3 - pT3bN0; No. 4 - pT3bN1b; No. 5 - pT3bN1b). Three out of the five patients also had adenomatous goiter. The mean follow-up time was 3.4 to 5.2 years. Results. Tumors in all patients were characterized by low mutational
The U.S. Food and Drug Administration (FDA) has given Priority Review designation to the New Drug Application for lenvatinib mesylate as a treatment for progressive radioactive iodine-refractory differentiated thyroid cancer. Lenvatinib is an oral multiple receptor tyrosine kinase inhibitor with a unique binding mode that selectively inhibits the kinase activities of vascular endothelial growth factor receptors, in addition to other proangiogenic and oncogenic pathway-related tyrosine kinases thought to be involved in tumor proliferation.. Priority Review designation is granted when the FDA believes the drug has the potential to provide a significant improvement in safety or effectiveness of the treatment, prevention, or diagnosis of a serious condition.. Lenvatinib was previously granted Orphan Drug designation for use in various types of thyroid cancer in the United States, Japan, and Europe. It is currently under investigation in thyroid, hepatocellular, endometrial, non-small cell lung ...
This study aims to determine the functional roles of microRNA-34b-5p (miR-34b) in the suppression of anaplastic thyroid carcinoma. We used hydration-of-freeze-dried-matrix (HFDM) formulated liposomes (liposome-loaded miR-34b) for effective delivery of miR-34b to anaplastic thyroid carcinoma in vitro and in vivo. Real time polymerase chain was used to determine the level of miR-34b. Immunocytochemistry, Western blot and ELISA were carried out to determine the effect of this manipulation on VEGF-A expression. In addition, an in vivo xenotransplantation mouse model was used to investigate the functional roles of overexpression of miR-34b in the carcinoma. In anaplastic thyroid carcinoma cells, miR-34b expression was low and significant overexpression (p , 0.05) was noted following transfection with liposome-loaded miR-34b. The miR-34b overexpressed thyroid carcinoma cell lines showed reduction in VEGF-A protein expression, decreased cell proliferation, decreased wound healing, reduced cell cycle ...
Though most types of thyroid cancer are cured by surgery and adjuvant radio- iodine therapy and TSH suppression, patients with radio-iodine refractory thyroid carcinoma as well as with medullary thyroid carcinoma, a neuroendocrine malignancy that does not express iodine transporter, are difficult to treat because of the lack of effective systemic treatment. Therefore, there is an urgent need of novel therapeutic measures for these patients. Thyroid cancer is frequently associated to the oncogenic conversion of protein kinases such as RET (medullary thyroid cancer) and BRAF (papillary and undifferentiated thyroid cancer). Therefore, protein kinase small molecule inhibitors (PKI) have been considered as promising novel agents for the treatment of thyroid carcinoma. Compounds that revealed good RET and BRAF activity both in clinical (vandetanib for RET) and in pre-clinical (vemurafenib for BRAF) settings have been identified. Recently, vandetanib was approved for patients with medullary thyroid ...
Objective: Describe a case of a patient diagnosed with papillary thyroid carcinoma by a retropharyngeal tumor.. Methods: A 46-year-old male was referred from the otorhinolaryngology consult to our department with the post-operative diagnosis of papillary thyroid carcinoma, with 6 months history of upper airway dyspnea and dysphagia to solids. Physical examination: right side adenopathies, not painful on palpation. No goitre. Laryngoscopy: hypertrophy of right posterior pharyngeal wall, epiglottis with rotation. Glotis was permeable. Mobile vocal cords. Pyriform sinus free. Cervical and thoracic TC: right retropharyngeal and internal jugular adenopathic conglomerates. Subcentimetrical mediastinal lymph nodes. Nasopharyngeal MRI: right retropharyngeal paracentral mass rejecting adjacent structures. FNA of cervical lymph node: lymph node with metastases of papillary thyroid carcinoma.. Results: Surgical treatment is decided. Transcervical excision was performed in right parapharyngeal tumor, ...
Anaplastic thyroid cancer arises from cells of the thyroid, which are normally involved in production and secretion of thyroid hormones, thyroxine (T4) and triiodothyronine (T3). Anaplastic thyroid tumor is always considered as stage IV. Genes involved in the pathogenesis of follicular thyroid cancer include P53 and BRAF. ...
Through a transcriptome microarray analysis, we have isolated Anterior gradient protein 2 (AGR2) as a gene up-regulated in papillary thyroid carcinoma (PTC). AGR2 is a disulfide isomerase over-expressed in several human carcinomas and recently linked to endoplasmic reticulum (ER) stress. Here, we analyzed the expression of AGR2 in PTC and its functional role. Expression of AGR2 was studied by immunohistochemistry and real time PCR in normal thyroids and in PTC samples. The function of AGR2 was studied by knockdown in PTC cells and by ectopic expression in non-transformed thyroid cells. The role of AGR2 in the ER stress was analyzed upon treatment of cells, expressing or not AGR2, with Bortezomib and analyzing by Western blot the expression levels of GADD153. PTC over-expressed AGR2 at mRNA and protein levels. Knockdown of AGR2 in PTC cells induced apoptosis and decreased migration and invasion. Ectopic expression of AGR2 in non-transformed human thyroid cells increased migration and invasion and
Surgery of well-differentiated thyroid carcinoma: the pendulum swings back in the central neck. Endocr Pract. 2010 Sep-Oct; 16(5):913-7 ...
Aschebrook-Kilfoy B, Ward MH, Sabra MM, Devesa SS. Thyroid cancer incidence patterns in the United States by histologic type, 1992-2006. Thyroid 2011;21(2):125-34. https://doi.org/10.1089/thy.2010.0021. Lang BH, Yih PCL, Shek TWH, Wan KY, Wong KP, Lo CY. Factors affecting the adequacy of lymph node yield in prophylactic unilateral central neck dissection for papillary thyroid carcinoma. J Surg Oncol 2012;106(8):966-71. https://doi.org/10.1002/jso.23201. American Cancer Society. Cancer Facts & Figures 2016. Atlanta: American Cancer Society; 2016 [cited 2016 November 10]. Available from: https://old.cancer.org/acs/groups/content/@research/documents/document/acspc-047079.pdf. Cooper D, Doherty G, Haugen B, Kloos R, Lee S, Mandel S, et al. American Thyroid Association (ATA) guidelines task force on thyroid nodules and differentiated thyroid cancer. Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid ...
TY - JOUR. T1 - Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression. AU - Champa, Devora. AU - Russo, Marika A.. AU - Liao, Xiao Hui. AU - Refetoff, Samuel. AU - Ghossein, Ronald A.. AU - Di Cristofano, Antonio. PY - 2014/10/1. Y1 - 2014/10/1. N2 - Poorly differentiated tumors of the thyroid gland (PDTC) are generally characterized by a poor prognosis due to their resistance to available therapeutic approaches. The relative rarity of these tumors is a major obstacle to our understanding of the molecular mechanisms leading to tumor aggressiveness and drug resistance, and consequently to the development of novel therapies. By simultaneously activating Kras and deleting p53 (Trp53) in thyroid follicular cells, we have generated a novel mouse model that develops papillary thyroid cancer invariably progressing to PDTC. In several cases, tumors further progress to anaplastic carcinomas. The poorly differentiated tumors are ...
Tumor invasiveness is directly related to the ability of tumor cells to migrate and invade surrounding tissues, usually degrading extracellular matrix. Despite significant progress in the knowledge about migration and invasion, there is much more to elucidate about their regulatory mechanisms, especially in cancer cells. MicroRNAs (miRs) were recently described as important regulators of migration. Differential expression of miRs in cancer is frequently associated with progression, invasion and metastasis. In papillary thyroid carcinoma (PTC), miR-146b-5p is highly expressed and positively correlated to the degree of malignancy. This study aimed to investigate the role of miR-146b-5p on the migratory and invasive behaviors of thyroid cells, using a non tumor rat thyroid follicular cell line (PCCl3) transfected with the miR-146b-5p genomic region, and two PTC cell lines (TPC-1 and BCPAP, bearing distinct oncogenic backgrounds), which express high levels of miR-146b-5p, after miR-146b inhibition by
Results: In 12 out of 4314 cases (0.27%) suspicious FNAB results were found. Suspicious thyroid lesion results were found in 9 patients (8 F, 1 M), aged 46-73 (average 56 years) followed up for 3-57 months after RT: papillary cancer in two patients, Hürthle cell tumour in one patient, and suspicious cells in two patients (with benign lesions on postoperative histopathology). Two patients refused surgery (a suspicion of papillary cancer in one case and suspicious cells in FNAB in the second case). A follicular tumour in FNAB was suspected in two cases (no data about the first, and the second with lung cancer was not operable). In the remaining 3 cases FNAB revealed lymph node metastases due to other cancers ...
Although conventional histology and FNA are considered as gold standards, the pathologists are confronted with difficulties in reaching an accurate differential diagnosis between benign and malignant thyroid nodules. To improve disease identification, immunohistochemical markers, such as cytokeratin-19 (CK19) and galectin-3, have been proposed and their efficiencies for thyroid cancer diagnosis have been evaluated. CK19 is the smallest member of cytokeratin family and belongs to the intermediate filaments. Several studies reported that CK19 expression is strong and diffuse in papillary carcinoma and absent or low in benign thyroid lesions (8,9,15-17). Galectin-3, a structurally unique member of galectin family with an N-terminal tail composed of nine collagen-like repeats and a peptide with sites for Ser phosphorylation (39), is anti-apoptotic, associated with the pathogenesis of well-differentiated thyroid carcinoma (7,10-14). However, these markers have shown some limitations because ...
1.A study by Kim et al evaluated the efficacy and safety of radiofrequency ablation for localized small recurrent thyroid cancers less than 2 cm by comparing them with those at repeat surgery.. 2. 73 patients with recurrent thyroid cancer who had been treated with (RFA) or repeat surgery.. 3. Recurrence-free survival rates and post-treatment complication rates were compared between RFA and reoperation groups.. 4.The 1- and 3-year recurrence-free survival rates and post-treatment hoarseness rates were comparable for RFA and reoperation groups.. 5. Post-treatment hypocalcemia occurred exclusively in the reoperation group.. 6 RFA may be an effective and safe alternative to repeat surgery in patients with locally recurrent small thyroid cancers.. Kim JH et al. Radiology. 2015;276(3):909-918.. RFA can also be used in combination with External beam to shrink thyroid cancer and relieve airway obstruction as seen in this case from Dr.JH Bek for Seoul Korea.. ...
TY - JOUR. T1 - The role of positron emission tomography/computed tomography in the management of recurrent papillary thyroid carcinoma. AU - Nahas, Zayna. AU - Goldenberg, David. AU - Fakhry, Carol. AU - Ewertz, Marjorie. AU - Zeiger, Martha. AU - Ladenson, Paul W.. AU - Wahl, Richard. AU - Tufano, Ralph P.. PY - 2005/2/1. Y1 - 2005/2/1. N2 - Objectives/Hypothesis: The aim of the study was to evaluate the role of combined positron emission tomography/computed tomography (PET/CT) fusion imaging in the detection and management of recurrent papillary thyroid cancer. Study Design: A retrospective analysis of 33 patients with suspected recurrent papillary thyroid carcinoma who had undergone PET/CT was performed. PET/CT was compared with standard imaging techniques in each patient to determine whether PET/CT contributed to the therapeutic management plan. Histopathological findings were correlated to PET/CT in patients who imderwent surgery. Methods: The senior author reviewed the charts of 33 ...
Second of a new series of Mini-Editorials in Thyroid News. While accounting for only 1% of solid malignancies, thyroid carcinoma is the most common malignancy of the endocrine system. The majority are patients with well-differentiated thyroid carcinoma of follicular cell origin who are cured with adequate surgical management and radioiodine therapy. However, some thyroid malignancies, such as medullary thyroid carcinoma (MTC) or poorly differentiated thyroid carcinoma, frequently metastasize, precluding patients from a curative resection.. The molecular bases of differentiated thyroid carcinoma, MTC, and anaplastic thyroid cancer are well characterized and the critical genetic pathways involved in the development of specific tumor histological types have been elucidated. Of primary importance has been the recognition of key oncogenic mutations such as BRAF, RET and RAS in papillary (PTC) and RET in medullary (MTC) carcinomas. These genes code for kinases that activate signalling through the ...
Six patients experienced voice change immediately after RFA. Voice change was recovered in 5 patients. One patient without recovery was treated with vocal cord medialization. All 6 patients with voice change had tumors in the level VI. There were no other significant complications, and most of the patients tolerated the RFA procedure well. Although some patients reported a burning sensation, pain, or both, the symptoms were relieved by reducing the RF power or stopping the ablation for several seconds.. In conclusion, RFA can be effective in treating loco-regional, recurrent, and well-differentiated thyroid carcinoma in patients at high surgical risk.. ...
Papillary thyroid cancer (PTC) is the most common tumor subtype of thyroid cancer. However, not all PTCs are responsive to current surgical and radioiodine treatment. The well-established clinical prognostic factors include tumor size, lymph node/distal metastasis, and extrathyroidal invasion. The RET/PTC-RAS-BRAF linear molecular signaling cascade is known to mediate PTC pathogenesis. However, whether presence of BRAF mutation, the most common genetic alteration in PTC, can affect PTC behavior and prognosis is controversial. MicroRNAs (miRNAs) have been labeled as promising molecular prognostic markers in several tumor types. Our recent studies demonstrated that microRNA-146b (miR-146b) deregulation is associated with PTC aggressiveness and prognosis. Here we summarize the current knowledge related to the functional roles, regulated target genes, and clinical applications of miR-146b in PTC and discuss how these studies provide insights into the key role of miR-146b as an oncogenic regulator promoting
TY - JOUR. T1 - Peripheral location and infiltrative margin predict invasive features of papillary thyroid microcarcinoma. AU - Lee, Woo Kyung. AU - Lee, Jandee. AU - Kim, Hyunji. AU - Lee, Seul Gi. AU - Choi, Sun Hyung. AU - Jeong, Seonhyang. AU - Kwon, Hyeong Ju. AU - Jung, Sang Geun. AU - Jo, Young Suk. PY - 2019. Y1 - 2019. N2 - Objective: Tumor location in papillary thyroid microcarcinoma (PTMC) might determine tumor outgrowth from the thyroid gland. However, the clinical implications of tumor location and minimal extrathyroid extension (mETE) have not been well elucidated. We aimed to investigate the relationship between tumor location and mETE to predict the aggressiveness of PTMC. Methods: A total of 858 patients with PTMC were grouped according to tumor location on ultrasonography: central (cPTMC) and peripheral PTMC (pPTMC). PTMC without mETE (PTMC-mETE(-)) was divided further according to margin shape: encapsulated (E-) or infiltrative (I-). To understand the molecular biologic ...
TY - JOUR. T1 - Clinicopathologic features and outcomes in patients with diffuse sclerosing variant of papillary thyroid carcinoma. AU - Akaishi, Junko. AU - Sugino, Kiminori. AU - Kameyama, Kaori. AU - Masaki, Chie. AU - Matsuzu, Kenichi. AU - Suzuki, Akifumi. AU - Uruno, Takashi. AU - Ohkuwa, Keiko. AU - Shibuya, Hiroshi. AU - Kitagawa, Wataru. AU - Nagahama, Mitsuji. AU - Shimizu, Kazuo. AU - Ito, Koichi. PY - 2015/7/5. Y1 - 2015/7/5. N2 - Background: Diffuse sclerosing variant (DSV) of papillary thyroid carcinoma (PTC) is a rare variant more common among younger patients. Materials and methods: Excluding patients with microcarcinoma, 5848 patients with PTC underwent initial surgery between 1995 and 2011. Twenty-two patients (0.4 %) were histologically diagnosed with DSV, of whom 20 (91 %) were ,45 years old. We compared clinicopathologic characteristics and outcomes between patients with DSV and those with classical PTC ,45 years old. Univariate analysis by the Kaplan-Meier method in ...
A series of 41 poorly differentiated follicular carcinomas of the thyroid gland without histopathological features of medullary or papillary carcinoma and 9 cases of undifferentiated thyroid carcinoma of the small cell type (diagnosed between 1967 and 1983) were investigated immunohistochemically. Two poorly differentiated follicular carcinomas showed a considerable number of calcitonin-positive cells in addition to the weakly thyroglobulin-positive tumor cells. One of these cases revealed several areas with calcitonin-positive tumor cells with additional squamous metaplasia with keratinization. No medullary carcinomas could be demonstrated among the 9 cases previously diagnosed as undifferentiated thyroid carcinomas of the small cell type. From the epidemiological point of view the application of immunohistochemistry does not significantly increase the proportion of medullary carcinomas detected in our endemic goiter area. The incidence of medullary carcinoma remains surprisingly low when ...
Premenopausal women are at highest risk for papillary and follicular thyroid carcinoma, implicating a role for estrogens in thyroid cancer. The expression of estrogen receptors α and β (ER), the effects of estradiol (E2), selective estrogen receptor modulators (SERMs) 4-hydroxytamoxifen and raloxifene, and ER subtype selective agonists were examined in NPA87 and KAT5 papillary and WRO follicular thyroid carcinoma cell lines. All three thyroid cancer cell lines expressed full-length ERα and ERβ proteins with cytoplasmic localization that was unaffected by E2. ICI 182,780 (Fulvestrant, an ER antagonist), and inhibitors of non-genomic E2-activated MAPK and PI3K signaling blocked E2-induced cell proliferation. SERMs acted in a cell line-specific manner. No E2-induced estrogen response element (ERE)-driven reporter activity was observed in transiently transfected thyroid cancer cells. However, E2 increased transcription of established endogenous E2-target genes, i.e., cathepsin D in WRO and ...
TY - JOUR. T1 - Cytologic features of infarcted thyroid papillary carcinoma induced by fine needle aspiration. AU - Jang, Se Min. AU - Jun, Young Jin. AU - Na, Woong. AU - Jang, Ki Seok. AU - Paik, Seung Sam. PY - 2010/1/1. Y1 - 2010/1/1. KW - Aspiration biopsy, fine-needle. KW - Carcinoma, papillary. KW - Infarction. KW - Thyroid neoplasms. UR - http://www.scopus.com/inward/record.url?scp=78650508591&partnerID=8YFLogxK. M3 - Letter. C2 - 21053614. AN - SCOPUS:78650508591. VL - 54. SP - 1082. EP - 1083. JO - Acta Cytologica. JF - Acta Cytologica. SN - 0001-5547. IS - 5. ER - ...
BACKGROUND/OBJECTIVES: Despite the importance of a low-iodine diet (LID) for thyroid cancer patients preparing for radioactive iodine (RAI) therapy, few studies have evaluated dietary intake during LID. This study evaluated the amount of dietary iodine intake and its major food sources during a typical diet and during LID periods for thyroid cancer patients preparing for RAI therapy, and examined how the type of nutrition education of LID affects iodine intake. SUBJECTS/METHODS: A total of 92 differentiated thyroid cancer patients with total thyroidectomy were enrolled from Seoul National University Hospital. All subjects completed three days of dietary records during usual and low-iodine diets before |TEX|$^{131}I$|/TEX| administration. RESULTS: The median iodine intake was |TEX|$290{\mu}g/day$|/TEX| on the usual diet and |TEX|$63.2{\mu}g/day$|/TEX| on the LID. The major food groups during the usual diet were seaweed, salted vegetables, fish, milk, and dairy products and the consumption of these
It remains controversial whether patients with papillary thyroid microcarcinoma (PTMC) benefit from total thyroidectomy (TT) or thyroid lobectomy (TL). We aimed to investigate the impact of extent of surgery on the prognosis of patients with unilateral PTMC. Patients were obtained from the Surveillance, Epidemiology, and End Results database from 2004 to 2015. Cancer-specific survival (CSS) and overall survival (OS) were evaluated by Cox regression and Kaplan-Meier curves with propensity score matching. Of 31167 PTMC patients enrolled, 22.2% and 77.8% of which underwent TL and TT, respectively. Patients with TT were more likely to be younger, females, present tumors of multifocality, extrathyroidal extension, cervical lymph node metastasis (CLNM), distant metastasis, and receive radioactive iodine (RAI) compared with those receiving TL. The multivariate Cox regression model showed that TT was not associated with an improved CSS and OS compared with TL with hazard ratio (HR) and 95% confidence interval
Hurthle cell tumors are an infrequent neoplasm of the thyroid gland in adults. Hurthle cell tumors represent 4. 5% to 10% of all primary thyroid epithelial neoplasms in the foreign literature. It has been known as Hurthle cell tumor since Ewing was the first to use this term in 1928. Tumor occurring in an infant was described by Symmers(1941) and Morrow(1945). The authors experienced a case of congenital Hurthle cell tumor of the thyroid gland in a 2 months old boy. He was admitted to the pediatric surgical department because of a growing mass in the neck since birth. Ultrasonogram showed a huge lobulated homogenous solid mass with medium level echogenicity in the region of the thyroid gland. Subtotal thyroidectomy of right lobe and total thyroidectomy of left lobe were done. The specimen measures 2x3x1.5 cm and 7x3x3 cm, respectively. It was an encapsulated, yellow gray firm and solid mass. The cut surface was smooth, glistening and homogenous. Microscopicully, the tumor was composed of tightly ...
Treatment with sorafenib in patients with progressive metastatic medullary thyroid cancer (MTC) is well tolerated and resulted in disease control.
Thyroid carcinoma is a common endocrine malignancy worldwide, accounting for approximately 1% of all diagnosed cancers and about 91.5% of the malignancies of head and neck. However, differentiating malignant thyroid nodules from benign ones remains a diagnostic challenge. Thus, novel molecular markers that enable non-invasive diagnostics for malignant thyroid nodules are urgently needed. In the present study, a metabonomic investigation based on liquid chromatography-LTQ Orbitrap mass spectrometry was employed for serum metabolic profiling of 30 cases of papillary thyroid carcinomas (PTC), 80 cases of nodular goiters (benign thyroid nodules) and 30 cases of healthy controls. According to the results of multivariate statistical data analysis, the significantly changed metabolites among these three groups were defined. It was found that most of these metabolites decreased in the sera of both malignant and benign thyroid cases due to the increased metabolic rate, which is in accordance with ...
Welcome to the ValueMD Albums. Thyroid Ultrasound. Images: WK 1 THYROID Transverse, WK 1 THYROID Papillary thyroid cancer | Radiology Reference Article | Radiopaedia.org Sonographic ap, WK 1 THYROID Colloid cyst, WK 1 THYROIDAdenomatous goiter. A well-circumscribed isoechoic mass (calipers) with rim-type smo, WK 1 THYROID Thyroid Nodules Surgery + Biopsy FNA, WK 1 THYROIDBenign thyroid adenoma, WK 1 THYROID Biopsy proven papillary carcinoma of thyroid- Right lobe with microcalcifications, WK 1 THYROID Papillary carcinoma of thyroid- Left lobe with increased vascular flow, WK 1 THYROID The thyroid gland is under the control of the pituitary gland, a small gland the size o, WK 1 THYROID adenomatous nodule Thyroid Ultrasound, Thyroid Ultrasound - Normal., Thyroid Gland Ultrasound Image (normal) with labels., WK 1 THYROID ultrasound image multinodular goitre with ectopic thyroid tissue, Large Thyroid Nodule, Thyroid nodule. transverse plane. lots of other thyroid images from ultrasound-images.com,
TY - JOUR. T1 - A comparison of medullary thyroid carcinoma and thyroid adenocarcinoma in dogs. T2 - a retrospective study of 38 cases.. AU - Carver, J. R.. AU - Kapatkin, Amy. AU - Patnaik, A. K.. PY - 1995/7. Y1 - 1995/7. N2 - The medical records of 38 dogs with thyroid neoplasia that were treated by surgical excision of the tumor, or had an incisional biopsy performed as a diagnostic procedure, were reviewed. Of the 38 dogs, 21 (55%) had resectable tumors, whereas 17 (45%) had an incisional biopsy as the tumors were nonresectable. All dogs had an initial diagnosis of thyroid carcinoma. The type of carcinoma was confirmed in 33 dogs by histological and immunohistochemical examination. Twelve dogs (36%) had medullary thyroid carcinoma, and 21 dogs (64%) had thyroid adenocarcinoma. Of the 12 dogs with medullary thyroid carcinoma, 10 (83%) had resectable tumors. Of the 10, three (30%) had at least a 1-year survival. None had radiographic evidence of metastasis at the time of surgery. Of the 21 ...
What is the best surgical treatment for papillary thyroid microcarcinoma (PTMC)? Background: Surgeons have debated whether to perform a total or
Medullary thyroid cancer. This type of thyroid cancer accounts for about 4 percent of all thyroid cancers. Medullary thyroid cancer begins in the parafollicular cells or C cells. This type of thyroid cancer is easier to control if it is found and treated early, before it spreads to other parts of the body. There are two types of medullary thyroid cancer: sporadic medullary thyroid cancer and familiar medullary thyroid cancer (FMTC). Because familiar medullary thyroid cancer tends to run in families, screening tests for genetic abnormalities in the blood cells may be conducted ...
Nuclear retinoid receptors (RARs) upon a ligand binding act as all-trans retinoic acid-inducible transcription factors interacting as conditional heterodimers with nuclear retinoid X (rexinoid) receptors (RXRs). The disruption of retinoic acid (RA) signalling pathways is believed to underlie the etiology of a number of malignancies. RAR and RXR ligands are known to play role in reprogramming several tumour cells, and thus the development of appropriate ligands with reduced teratogenic and other side effects are still highly required. In this study, we have investigated expression pattern of retinoid receptor subtypes (RARalpha, RARbeta, RARgamma) and retinoid X nuclear receptor subtypes (RXRalpha, RXRbeta, RXRgamma) in three different human organ malignancies, i) thyroid papillary carcinoma, ii) breast cancer, and iii) renal carcinoma.. ...
Aim: Differentiation of thyroid nodules, either as benign or malignant, is a real diagnostic challenge. Inflammation has an important role in development of the malignancy. Therefore, inflammatory markers are associated with malignant thyroid nodules. Platelet /lymphocyte ratio (PLR) is also one of the novel inflammatory indices derived from hemogram tests. We hypothesized whether PLR was associated with malignant thyroid nodules. For this purpose, we compared PLR levels of the patients with benign thyroid nodules to the PLR of the subjects with malignant nodules.. Methods: The subjects who visited outpatient internal medicine clinics of our institution with a diagnosis of thyroid nodule were enrolled to the present retrospective study. According to the examination of the fine needle aspiration cytology (FNAC) specimen of the nodules, patients grouped into benign or malignant nodule groups. PLR of groups were compared.. Results: Median PLR values of the benign and malignant thyroid nodule groups ...
TY - JOUR. T1 - Interplay between Ret and Fap-1 regulates CD95-mediated apoptosis in medullary thyroid cancer cells. AU - Nicolini, Valentina. AU - Cassinelli, Giuliana. AU - Cuccuru, Giuditta. AU - Bongarzone, Italia. AU - Petrangolini, Giovanna. AU - Tortoreto, Monica. AU - Mondellini, Piera. AU - Casalini, Patrizia. AU - Favini, Enrica. AU - Zaffaroni, Nadia. AU - Zunino, Franco. AU - Lanzi, Cinzia. PY - 2011/10/1. Y1 - 2011/10/1. N2 - Emerging evidence suggests that Ret oncoproteins expressed in medullary thyroid cancer (MTC) might evade the pro-apoptotic function of the dependence receptor proto-Ret by directly impacting the apoptosis machinery. Identification of the molecular determinants of the interplay between Ret signaling and apoptosis might provide a relevant contribution to the optimization of Ret-targeted therapies. Here, we describe the cross-talk between Ret-M918T oncogenic mutant responsible for type 2B multiple endocrine syndrome (MEN2B), and components of death ...
Purpose: While the molecular basis of hereditary medullary thyroid cancer (HMTC) has been well defined, little is known about the molecular pathogenesis of sporadic medullary thyroid cancer (SMTC). In addition, microRNAs (miRNAs) have been shown to be important diagnostic and prognostic markers in cancer but have not been defined in MTC. Our aim was to study the miRNA profile of MTC to identify prognostic biomarkers and potential therapeutic targets.. Experimental Design: MiRNA microarray profiling was carried out in fresh frozen tissues from patients with SMTC (n = 12) and HMTC (n = 7). Differential expression of three miRNAs was confirmed in a validation cohort of SMTC and HMTC samples (n = 45) using quantitative reverse transcriptase-PCR and correlated with clinical outcomes. The functional role of a selected miRNA was investigated in vitro in the human medullary thyroid carcinoma cell line (TT cells) using cell proliferation assays and Western blotting analysis.. Results: MiRs-183 and 375 ...
BACKGROUND The indications and extent of cervical lymph node dissection in papillary thyroid carcinoma (PTC) are still being debated. The aim of this study was to analyze the patterns of cervical lymph node metastasis in the lateral and central compartment and related factors and suggest the optimal extent of lateral and central neck dissection for PTC patients with clinical lateral lymph node metastasis. METHODS We retrospectively analyzed 72 patients with unilateral PTC who underwent therapeutic lateral neck dissections with concomitant total thyroidectomy and central neck dissection between January 2001 and December 2009. RESULTS The 72 patients underwent 79 sides of therapeutic lateral neck dissection. The most frequent metastatic level in the ipsilateral lateral compartment was level IV (75.0%), followed by level III (69.4%), level II (56.9%) and level V (20.8%). Multiple level metastases were common (77.8%) and were correlated with tumor size (≥ 10 mm). The central compartment lymph node
Follicular thyroid carcinoma comprises about 25% of all thyroid cancers, and its malignancy generally exceeds that of papillary carcinoma. It spreads relatively early to distant sites such as bone, lungs, and liver by invasion of blood vessels, and regional lymph nodes are usually involved only late. Production of thyroid hormones is almost exclusively associated with the follicular histologic type. In many reported cases the production of thyroid hormones by metastases has been sufficient to cause hyperthyroidism. One of these cases was that of a patient with T3 thyrotoxicosis (1).. We describe here a patient having metastatic follicular thyroid carcinoma with ...
Familial medullary thyroid cancer (FMTC) is a type of medullary thyroid cancer. About 25% of the reported cases of medullary thyroid cancer are FMTC. FMTC most commonly includes MEN 2A (multiple endocrine neoplasia). Patients with familial medullary thyroid cancer are usually treated with a total thyroidectomy, which is a removal of all or part of the thyroid gland, as well as radiation therapy or chemotherapy ...
The study by Zevallos et al., aimed to determine if the increased thyroid cancer incidence observed corresponded with a similar increase in the use of diagnostic investigations. Thyroid ultrasound and fine needle aspiration. This was achieved by examining the Veterans Affairs health system records. The number of cases of thyroid cancer and the numbers of diagnostic investigations performed in the period between the years 2000 and 2012 were compared. At the commencement of the study in 2000, the incidence of thyroid cancer was 10.3 cases per 100,000 people. In comparison, at the studys conclusion in 2012, the incidence of thyroid cancer was 21.5 cases per 100,000 people.. As with the incidence of thyroid cancer during the study period, the use of ultrasound and fine needle aspiration biopsy also exhibited an increase. In 2000, the rate of thyroid ultrasound was 125.6 per 100,000 people, which had increased to 572.1 per 100,000 people in 2012. Similarly, in 2000 the rate of fine needle ...
TY - JOUR. T1 - Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. AU - Dahia, Patricia L.M.. AU - Marsh, Debbie J.. AU - Zheng, Zimu. AU - Zedenius, Jan. AU - Komminoth, Paul. AU - Frisk, Tony. AU - Wallin, Goran. AU - Parsons, Ramon. AU - Longy, Michel. AU - Larsson, Catharina. AU - Eng, Charis. PY - 1997/11/1. Y1 - 1997/11/1. N2 - The majority of familial medullary thyroid neoplasms are associated with germ-line mutations of the RET proto-oncogene, yet very little is known about the mechanisms involved in the pathogenesis of familial and sporadic nonmedullary thyroid tumors. A subset of thyroid tumors have loss of heterozygosity of chromosome 10q22-23, a region harboring the gene responsible for Cowden disease, an autosomal dominant hamartoma syndrome associated with thyroid and breast tumors. PTEN/MMAC1/TEP1 codes for a dual- specificity phosphatase and is likely a tumor suppressor gene. We sought to determine the PTEN status in a series of ...
We used US to assess for nodule growth and morphological change in 202 benign thyroid nodules with a mean follow-up of 21 months. However, this study did not show any association between US change and nodule growth. The natural history of benign thyroid nodules, particularly with respect to nodule growth, has been evaluated by only a few studies that demonstrated that nodule growth rarely equated to malignancy [2-5]. In addition, a variety of morphological abnormalities have been previously seen on US in benign nodules during follow-up [10,11]. However, the relationship between morphological change and nodule volume change has rarely been probed. In a study that evaluated US features of benign thyroid nodules, hypoechogenicity was proposed as an independent factor for predicting nodule growth at 15% increases in volume [4]. Another study investigating the effect of FNA on nodule volume showed no statistically significant relationship between the absolute or percent change in thyroid nodule size ...
To identify serum biomarkers of papillary thyroid cancer. Prospective analysis was performed of banked tumor and serum specimens from 99 patients with thyroid masses. Enzyme-linked immunosorbent assay (ELISA) was employed to measure levels of five serum proteins previously demonstrated to be up-regulated in papillary thyroid cancer (PTC): angiopoietin-1 (Ang-1), cytokeratin 19 (CK-19), tissue inhibitor of metalloproteinase-1 (TIMP-1), chitinase 3 like-1 (YKL-40), and galectin-3 (GAL-3). Serum levels were compared between patients with PTC and those with benign tumors. A total of 99 patients were enrolled in the study (27 men, 72 women), with a median age of 54 years. Forty-three patients had PTC and 58 cases were benign tumors. There were no statistically significant differences when comparing all five different biomarkers between PTC and other benign thyroid tumors. The p-values were 0.94, 0.48, 0.72, 0.48, and 0.90 for YKL-40, Gal-3, CK19, TIMP-1, and Ang-1, respectively. Serum levels of four of the
Falls Church, Virginia. Sep. 22, 2012-A spectrum of disparities exist in the surgical management of well-differentiated thyroid cancer, according to new data presented at the 82nd Annual Meeting of the American Thyroid Association (ATA) in Québec City, Québec, Canada.. Current ATA guidelines for well-differentiated thyroid cancer recommend therapeutic neck dissection for clinically involved or metastatic disease and prophylactic central neck dissection for advanced tumors. However, even with established guidelines in place, the surgical management of cervical nodes varies greatly.. A team of researchers led by Katherine Hayes, MD, of Emory University in Atlanta, Ga., reviewed data on 127,192 patients with papillary and follicular thyroid cancer who were treated surgically from 1998 to 2009 to identify disparities in the extent of lymph node dissection during thyroidectomy. Variables examined included patient age, race, gender, insurance status and education level, hospital classification, ...
We report for the first time a synchronous papillary and follicular thyroid carcinoma in a 12-year-old girl presenting with a large (5 cm diameter) left thyroid nodule, an increased left and right upper pole technetium tracer uptake at scintigraphy and hyperthyroidism. The uptake at the right lobe was explained by the crossing of the left nodule to the right site of the neck at Computed Tomography (CT) scanning. Although thyroid nodules are less common in children than in adults, there is more vigilance required in children because of the higher risk of malignancy. According to literature, about 5% of the thyroid nodules in adults are malignant versus 20-26% in children. The characteristics of 9 other pediatric cases with a differentiated thyroid carcinoma presenting with a toxic nodule, which have been reported during the last 20 years, are summarized. A nodular size of more than 3.5 cm and female predominance was a common finding. The presence of hyperthyroidism in association with a hyperfunctioning
Warthin-like variant of papillary thyroid carcinoma (WLV-PTC) is a recently described rare variant of papillary thyroid carcinoma with favorable prognosis. We present a rare case of WLV-PTC in a 29-year-old female patient with graves disease along with emphasis on the difficulty of positive diagnosis both clinically and histologically since the association of thyroid nodules with Graves disease is not common and this variant of thyroid cancer is frequently misdiagnosed with other subtypes.
A patient with an apparent sporadic medullary thyroid carcinoma was tested for RET germline mutations by Sanger sequencing of RET exons 10, 11, and 13-16. The patient was heterozygous for two known mutations causative of Multiple Endocrine Neoplasia type 2 disorder, and both mutations were within codon 620 of RET exon 10, c.1859G > T (p.C620F) and c.1860C > G (p.C620W). In order to determine if these adjacent mutations were in cis or in trans, an unlabeled probe method and high-resolution melting analysis were utilized. The mutations were confirmed to occur in cis, representing a novel mutation, c.1859_1860delinsTG (p.C620L). Sanger sequencing of parental samples did not identify any changes at codon 620, so the p.C620L mutation is also de novo. The early age of onset for medullary thyroid carcinoma and the presence of lymph node metastasis in this patient suggests individuals with the p.C620L mutation should be treated and screened (for pheochromocytomas and parathyroid hyperplasia) as Multiple
Medullary thyroid carcinoma comprises less than 10% of all thyroid cancers. This specific type has significant diagnostic importance due to its aggressive nature and close association with multiple endocrine neoplasia syndromes. Approximately 10% to 20% cases affected by medullary thyroid carcinoma are familial. In the majority of cases nodal metastases are present at the moment of diagnosis ...
Results: CD56 expression was significantly higher in papillary thyroid carcinoma (PTC) (conventional and follicular variants) compared to other categories of follicular thyroid lesions, and it was significantly higher in the follicular variant of papillary carcinoma compared to follicular adenomas (FA) and hyperplastic nodules (HN). A bivariate analysis showed that the malignancy in follicular thyroid lesions was significantly associated with higher CD56 expression and older patients age. Both parameters were used to build a logistic regression model and equation for prediction of malignancy in follicular thyroid lesions. On the application of the equation to the studied cases, it was found to conform to their diagnostic nature ...
Article discusses medullary thyroid cancer basics. Learn about common medullary thyroid cancer symptoms and treatments, such as thyroidectomy.
I just had my thyroid surgery. When can I have my radioactive iodine treatment?. In order for the radioactive iodine treatment to be effective and destroy any remaining thyroid tissue, the levels of TSH, secreted by the pituitary gland must rise to elevated levels. TSH, also known as thyroid stimulating hormone, stimulates the thyroid cells to take up the radioactive iodine. For the levels of TSH to rise, the levels of thyroid hormone must have dropped to very low levels. As thyroid hormone has a long half life, it takes many weeks for levels to drop and TSH levels to rise. Accordingly, the earliest time interval that radioactive iodine can be effectively administered is 4 weeks after surgery (complete removal of the thyroid) if the patients has stopped taking all thyroid hormone supplements. To avoid prolonged hypothyroidism, some patients will use Thyrogen. Others will take Cytomel (T3), which must be stopped ~ 14 days prior to the radioactive iodine treatment. Hence, although many patients ...
Part 1 Low Risk Differentiated Thyroid Cancer: Preoperative diagnosis -- Chapter 1 A patient with a single thyroid nodule suspicious for follicular neoplasm according to the Bethesda System for Reporting Thyroid Cytopathology: molecular evaluation -- Part 2 Low Risk Differentiated Thyroid Cancer: Initial management: extent of surgery and use of radioactive iodine therapy -- Chapter 2 A case of a small (1 to 2 cm) papillary thyroid cancer in a young patient: lobectomy vs. total thyroidectomy -- Chapter 3 The decision-making process for prophylactic central neck dissection in a patient presenting with nodular thyroid disease suspicious for malignancy on cytology assessment: role of preoperative ultrasound and molecular marker testing -- Chapter 4 Incidentally discovered micropapillary thyroid cancer -- Chapter 5 Completion thyroidectomy in a patient with low risk papillary cancer -- Chapter 6 A case of multifocal micropapillary thyroid cancer -- Chapter 7 A papillary thyroid cancer with minimal ...
Medullary Thyroid Cancer Treatment for children is a lifesaving process. Learn more about Medullary Thyroid Cancer risk factors, symptoms, and treatment.
Image:Medullary thyroid carcinoma - low mag.jpg, Low magnification micrograph of medullary thyroid carcinoma,ref, Medullary thyroid cancer ...
This nonrandomized, parallel-assignment, phase 2, open-label clinical trial will assess the efficacy and safety of pembrolizumab (Keytruda) in patients with medullary thyroid cancer. Patients aged ≥18 years who have recurrent or metastatic medullary thyroid cancer, and for whom surgery is not a curative option, may be eligible for enrollment if other criteria are met. Participants with or without previous vaccine therapy will receive pembrolizumab.. The primary outcome measure is to determine whether administering a PD-1 inhibitor to patients with medullary thyroid cancer will permit a modest fraction to be able to experience a ≥50% decline in calcitonin levels or have a partial or complete response on imaging. The secondary outcome measures are to determine the impact of previous therapeutic cancer vaccination on response rates, evaluate immune responses in each cohort, evaluate changes in carcinoembryonic antigen and calcitonin kinetics, evaluate impact on PFS and OS, and evaluate the ...
Following up this article.. Malignant and possible malignant thyroid tumor of Fukushima children increased from 58 to 75 cases [URL]. Malignant and possible malignant thyroid tumor cases increased from 75 to 90 at the end of this March. Fukushima prefectural government announced on 5/19/2014.. Among 90 cases, 50 cases were confirmed as thyroid cancer.. The youngest child was 6 years old, the oldest child was 18 years old when 311 took place.. However the committee of experts stated it is hard to assume there is a connection with Fukushima nuclear accident.. http://www.pref.fukushima.lg.jp/uploaded/attachment/65174.pdf. http://ceron.jp/url/news.goo.ne.jp/article/jiji/nation/jiji-140519X151.html. ...
Dr. Keshab Paudel answered: Please see below: Papillary and follicular thyroid cancers are referred to as differentiated thyroid...
Introduction: Genomic instability has been proposed to play a role in cancer development and can occur through different mechanisms including telomere association and telomere loss. Studies carried out in our unit have demonstrated that familial papillary thyroid cancer (fPTC) patients display an imbalance, at the germinal level, in telomere-telomerase complex. Aim: We aimed to verify whether familial fPTC patients show an increased spontaneous chromosome fragility. Methods: To this purpose, we compared telomeric fusions and associations as well as other chromosomal fragility features by conventional and molecular cytogenetic analyses, in phytohemagglutinin stimulated T-lymphocytes from fPTC patients, unaffected family members, sporadic papillary thyroid cancer patients, and healthy subjects. Results: We demonstrate that fPTC patients have a significant increase in spontaneous telomeric associations and telomeric fusions compared with healthy subjects and sporadic cases in the frame of an ...
Diagnosis of benign and malignant lesions of thyroid by FNAC and AgNO3, 978-3-659-71714-7, Benign thyroid nodules are common in adults and thyroid malignancy is the most common malignancy of endocrine system. Papillary thyroid carcinoma and follicular thyroid carcinoma are often curable and prognosis is good if identified in early stage.To avoid unnecessary surgery Fine needle aspiration cytology (FNAC) is used as a diagnostic tool to differentiate benign nodule from malignant nodule. To improve the diagnostic accuracy of FNAC ,silver nitrate staining technique is applied. Smear from patients is stained with silver nitrate and nucleolar organising regions (segments of DNA) were stained as brown/black spots called AgNORs. Neoplastic and non-neoplastic lesions are differentiated by this technique. A total number of 119 cases were subjected to FNAC. Most cases occurred in females(94%) Maximum number of cases were seen in age group 21 to 30 years. There was significant higher AgNORs score in malignant
TY - JOUR. T1 - Angiography effectively supports the diagnosis of hepatic metastases in medullary thyroid carcinoma. AU - Ésik, Olga. AU - Szavcsur, Péter. AU - Szakáll, Szabolcs. AU - Bajzik, Gábor. AU - Repa, Imre. AU - Dabasi, Gabriella. AU - Füzy, Márton. AU - Szentirmay, Zoltán. AU - Perner, Ferenc. AU - Kásler, Miklós. AU - Lengyel, Zsolt. AU - Trón, Lajos. PY - 2001/6/1. Y1 - 2001/6/1. N2 - BACKGROUND. Medullary thyroid carcinoma (MTC) belongs in the group of neuroendocrine tumors with early lymphatic and hepatic dissemination. A high rate of undetectable metastases is hypothesized to be responsible for the frequent mismatch between the apparent relatively small tumor burden and the elevated plasma tumor marker level. METHODS. Thirty-six MTC patients with residual/recurrent biochemical signs (elevated basal calcitonin level) and/or characteristic general symptoms (diarrhea and/or flushing) were systematically examined by conventional radiology, wholebody 18F-deoxyglucose ...
Purpose: To study the safety of prophylactic level VII nodal dissection regarding hypoparathyroidism (temporary and permanent) and vocal cord dysfunction (temporary and permanent) and its impact on disease free survival. Materials and Methods: This prospective study concerned 63 patients with papillary thyroid carcinoma with N0 neck node involvement (clinically and radiologically) in the period from December 2009 to May 2013. All patients underwent total thyroidectomy and prophylactic central neck dissection including levels VI and VII lymph nodes in group A (31 patients) and level VI only in group B (32 patients). The thyroid gland, level VI and level VII lymph nodes were each examined histopathologically separately for tumor size, multicentricity, bilaterality, extrathyroidal extension, number of dissected LNs and metastatic LNs. Follow-up of both groups, regarding hypoparathyroidism, vocal cord dysfunction and DFS, ranged from 6-61 months. Results: The mean age was 34.8 and 34.3, female predominance
Purpose: To study the safety of prophylactic level VII nodal dissection regarding hypoparathyroidism (temporary and permanent) and vocal cord dysfunction (temporary and permanent) and its impact on disease free survival. Materials and Methods: This prospective study concerned 63 patients with papillary thyroid carcinoma with N0 neck node involvement (clinically and radiologically) in the period from December 2009 to May 2013. All patients underwent total thyroidectomy and prophylactic central neck dissection including levels VI and VII lymph nodes in group A (31 patients) and level VI only in group B (32 patients). The thyroid gland, level VI and level VII lymph nodes were each examined histopathologically separately for tumor size, multicentricity, bilaterality, extrathyroidal extension, number of dissected LNs and metastatic LNs. Follow-up of both groups, regarding hypoparathyroidism, vocal cord dysfunction and DFS, ranged from 6-61 months. Results: The mean age was 34.8 and 34.3, female
2Department of Endocrinology, Gulhane Military Medical Academy, Ankara-Turkey Brain metastasis is an uncommon and morbid complication of thyroid carcinoma, especially follicular carcinoma. Because of its rarity, management is still debated.. A 64-year-old woman presented with signs of blindness. After ophthalmological and radiological evaluations, A frontobasal mass lesion was detected. The lesion was removed and pathological examination revealed the diagnosis of follicular thyroid carcinoma metastasis. The patient also underwent thyroidectomy, radiotherapy and chemotherapy for follicular carcinoma.. This case shows that the follicular thyroid carcinoma may present with distant metastasis even if it is a rare occurence. Keywords : Follicular thyroid carcinoma, brain metastasis, surgery ...
Chapter 20 - NEOPLASMS OF THE THYROID - in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins ...
Chapter 20 - NEOPLASMS OF THE THYROID - in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007). ... malignant melanoma, papillary thyroid cancer, colorectal cancer, and ovarian cancer[22]. Involved in organism development, cell ... adenocarcinomas of the pancreas and colon, thyroid tumors, and myeloid leukemia[24]. involved in signalling a major pathway ...
... thyroid, adrenal gland, pancreas). ... benign neoplasms, in situ neoplasms, malignant neoplasms, and ... The term 'neoplasm' is a synonym of "tumor". 'Neoplasia' denotes the process of the formation of neoplasms/tumors, the process ... "II Neoplasms". World Health Organization. Retrieved 19 June 2014.. *^ a b Abrams, Gerald. "Neoplasia I". Retrieved 23 January ... Malignant neoplasms[edit]. DNA damage[edit]. The central role of DNA damage and epigenetic defects in DNA repair genes in ...
Other endocrine and non-endocrine neoplasms including adrenocortical and thyroid tumors, visceral and cutaneous lipomas, ... FMTC = familial medullary thyroid cancer MEN 2B is sometimes known as MEN 3 and the designation varies by institution (c.f. www ... MEN IIa (2Ps, 1M) - Pheochromocytoma, Parathyroid, Medullary Thyroid Ca. MEN IIb (1P, 2Ms) - Pheochromocytoma, Medullary ... Sipple JH (1961). "The association of pheochromocytoma with carcinoma of the thyroid gland". Am. J. Med. 31: 163-6. doi:10.1016 ...
"Malignant and benign neoplasms of the thyroid in patients treated for hyperthyroidism: a report of the cooperative ... Treatment of thyroid cancer[edit]. Iodine-131, in higher doses than for thyrotoxicosis, is used for ablation of remnant thyroid ... The image of the thyroid in the neck is due to unwanted uptake of radioiodine (as iodide) by the thyroid, after breakdown of ... For example, children treated with moderate dose of 131I for thyroid adenomas had a detectable increase in thyroid cancer, but ...
Erickson, Lori A. "Hurthle Cell Thyroid Neoplasms." Atlas of Endocrine Pathology. Springer New York, 2014. 63-66. Hürthle, Karl ... of all differentiated thyroid cancers. Oncocytes in the thyroid are often called Hürthle cells. Although the terms oncocyte, ... formerly considered a subtype of follicular thyroid cancer). This version is a relatively rare form of differentiated thyroid ... Typically a painless thyroid mass is found in patients with this type of cancer. As expected, patients with carcinoma usually ...
... papillary thyroid carcinoma, non-small cell lung cancer, glioma, gastric cancer, thyroid neoplasms, and rectal cancer. It is ... papillary thyroid carcinoma and non-small cell lung cancer, glioma, gastric cancer, thyroid neoplasms, and rectal cancer. Barth ... In thyroid neoplasm, TAZ allows follicular adenomas to be distinguished from follicular carcinomas, while in cervical cancer ... TAZ overexpression has been linked to rectal cancer, prostate cancer, thyroid neoplasm, and cervical cancer. In a study of 140 ...
2009) Information theoretical methods to deconvolute genetic regulatory networks applied to thyroid neoplasms. (2009) Análisis ... Accuracy of centinel node in papillary thyroid carcinoma (2001) Quality of life in bariatric surgery (2002) Utilidad de la ...
"Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms". Thyroid. 15 (10): 1131-6 ...
... putative markers for characterization of follicular thyroid neoplasms from fine-needle aspirates". Laryngoscope. 121 (5): 983-9 ... ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors". Mod. Pathol. 25 (4): 537-47. doi:10.1038/modpathol. ...
"Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms". Thyroid. 15 (10): 1131-6 ... Fluge Ø, Bruland O, Akslen LA, Varhaug JE, Lillehaug JR (2002). "NATH, a novel gene overexpressed in papillary thyroid ...
The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer". Thyroid. 26: 1- ... Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was ... Definition of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A noninvasive neoplasm that ... "Thyroid FNA cytology in Asian practice-Active surveillance for indeterminate thyroid nodules reduces overtreatment of thyroid ...
A challenging neoplasm of the thyroid". Endocrine Practice. 17 (6): e140-3. doi:10.4158/EP11138.CR. PMID 21940281. v t e. ... Hyalinizing trabecular adenoma (or Hyalinizing trabecular adenoma) is a subtype of thyroid adenoma. Ünlütürk, U; Karaveli, G; ...
Increased risk for thyroid neoplasm remains elevated for at least 40 years after exposure. Potassium iodide tablets prevent ... None had thyroid cancer.[citation needed] Fukushima Medical University gives the number of children diagnosed with thyroid ... Persons exposed to releases of I-131 from any source have a higher risk for developing thyroid cancer or thyroid disease, or ... Ultrasonographic detectable thyroid nodules and cysts are extremely common and can be found at a frequency of up to 67% in ...
Hemorrhagic neoplasms are more complex, heterogeneous bleeds often with associated edema. These hemorrhages are related to ... Glioblastomas are the most common primary malignancies to hemorrhage while thyroid, renal cell carcinoma, melanoma, and lung ... of consciousness Hypertension Arteriovenous malformation Aneurysm rupture Cerebral amyloid angiopathy Intracranial neoplasm ...
... one of the Coloured Book protocols Noninvasive follicular thyroid neoplasm with papillary-like nuclear features - a tumour ... previously classified as papillary thyroid carcinoma This disambiguation page lists articles associated with the title NIFTP. ...
Several severe adverse health effects, such as an increased incidence of cancers, thyroid diseases, CNS neoplasms, and possibly ... and thyroid tissues as the most radiosensitive among women. For example, the FGR 13 has estimated that the ratio of thyroid ... The Hanford Thyroid Disease Study, an epidemiologic study of the relationship between estimated exposure doses to radioiodine ... The increased radiosensitivity of certain organs in women, such as the breast, ovaries, and thyroid is likely the cause of this ...
... system lists a number of morphological subtypes and variants of malignant squamous cell neoplasms, including: Papillary thyroid ... A type of lung cancer Squamous cell thyroid carcinoma: A type of thyroid cancer Esophageal squamous cell carcinoma: A type of ... Syed MI, Stewart M, Syed S, Dahill S, Adams C, McLellan DR, Clark LJ (January 2011). "Squamous cell carcinoma of the thyroid ... Primary squamous cell thyroid carcinoma shows an aggressive biological phenotype resulting in poor prognosis for patients. ...
It can be present in: Thyroid neoplasms: It is a characteristic feature of papillary thyroid carcinoma, but has also been seen ... in other types of thyroid neoplasms, as well as in non-neoplastic thyroid lesions. Ovarian tumors including Brenner tumors, ... Breast carcinomas Vaginal, cervical and/or endometrial neoplasms Papillary neoplasms of several organs: papillary transitional ... Pathogenesis and Diagnostic Significance of Nuclear Grooves in Thyroid and Other Sites". International Journal of Surgical ...
... dysplasia Thymoma Thymus neoplasm Thyrocerebrorenal syndrome Thyroglossal tract cyst Thyroid agenesis Thyroid cancer Thyroid ... carcinoma, follicular Thyroid carcinoma, papillary (TPC) Thyroid hormone plasma membrane transport defect Thyroid, renal and ... Temtamy-Shalash syndrome TEN Ter Haar-Hamel-Hendricks syndrome Ter Haar syndrome Teratocarcinosarcoma Teratoma Testes neoplasm ... syndrome Tolosa-Hunt syndrome Toluene antenatal infection Tomaculous neuropathy Tome-Brune-Fardeau syndrome Tongue neoplasm ...
"Colloid-Rich" follicular neoplasm/suspicious for follicular neoplasm thyroid fine-needle aspiration specimens: Cytologic, ... Highly accurate diagnosis of cancer in thyroid nodules with follicular neoplasm/suspicious for a follicular neoplasm cytology ... Noninvasive follicular thyroid neoplasms cause little risk for patients Dr. Nikiforov on Reclassifying Subtype of Thyroid ... The patients still undergo surgery, in which their thyroid tumors are removed, typically with half, but not all, of the thyroid ...
... the ICD-10 code for a benign neoplasm of thyroid gland the Tarrasch Defense chess code This disambiguation page lists articles ...
Atomic bombings of Hiroshima and Nagasaki Takashi Nagai Nippon Foundation Chernobyl disaster Thyroid neoplasm Fukushima: a ... He eventually concluded the effects of radiation in the area as follows: "Apart from the dramatic increase in thyroid cancer ... Under the current levels, administering iodine pills is unnecessary." Meanwhile, as the president of the Japan Thyroid ... high radiation doses required people to take iodine pills for thyroid blockage by the standard of Japan (100mSV) and WTO (10mSV ...
Over 90% of thyroid tumors arise from follicular thyroid cells.[8] A fusion protein, PAX8-PPAR-γ, is implicated in some ... aka Hurthle-Cell Neoplasms).[15] Tumors expressing the PAX8/PPARy are usually present in at a young age, small in size, present ... thyroid gland development. • positive regulation of thyroid hormone generation. • negative regulation of apoptotic process ... Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular ...
The most common neoplasm affecting the thyroid gland is a benign adenoma, usually presenting as a painless mass in the neck. ... thyroid inflammation (thyroiditis), thyroid enlargement (goitre), thyroid nodules, and thyroid cancer. Hyperthyroidism is ... The superior thyroid artery splits into anterior and posterior branches supplying the thyroid, and the inferior thyroid artery ... "Thyroid History Timeline - American Thyroid Association". www.thyroid.org. Retrieved 13 November 2016. Gray's Anatomy 2008, pp ...
... an enzyme involved with thyroid hormones D01, an ICD-10 Chapter II: Neoplasms code Nikon D1, a digital single-lens reflex ...
A challenging neoplasm of the thyroid". Endocrine Practice. 17 (6): e140-3. doi:10.4158/EP11138.CR. PMID 21940281. Carlé, Allan ... emedicine > Thyroid, Evaluation of Solitary Thyroid Nodule > Benign Thyroid Nodules By Daniel J Kelley and Arlen D Meyers. ... A thyroid adenoma is a benign tumor of the thyroid gland, that may be inactive or active (functioning autonomously) as a toxic ... A thyroid adenoma is distinguished from a multinodular goiter of the thyroid in that an adenoma is typically solitary, and is a ...
Newly reclassified variant: noninvasive follicular thyroid neoplasm with papillary-like nuclear features is considered an ... Stage M1 thyroid cancer Stage N1a thyroid cancer Stage N1b thyroid cancer Stage T1a thyroid cancer Stage T1b thyroid cancer ... The four main types are papillary thyroid cancer, follicular thyroid cancer, medullary thyroid cancer, and anaplastic thyroid ... thyroid cancer Stage T3 thyroid cancer Stage T4a thyroid cancer Stage T4b thyroid cancer Detection of any metastases of thyroid ...
Thyroid and pancreas cancer may also occur. Although J Aidan Carney also described Carney's triad it is entirely different. ... Epithelioid blue nevus List of cutaneous neoplasms associated with systemic syndromes Carney Syndrome at eMedicine Carney, J.; ... Bano G, Hodgson S (2016). "Diagnosis and Management of Hereditary Thyroid Cancer". Recent Results Cancer Res. 205: 29-44. doi: ... "Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association". J Clin Endocrinol Metab. 96 (11): ...
Thyroid cancer. *Tumors of the hematopoietic and lymphoid tissues. U. *Ureteral cancer ... Salivary gland neoplasm. *Sarcoma. *Skin cancer. *Small intestine cancer. *Small-cell carcinoma ...
Neoplasms include: *Pheochromocytoma (most common), a catecholamine-secreting tumor of the adrenal medulla[1][5] ...
Examples are the infusion of metaiodobenzylguanidine (MIBG) to treat neuroblastoma, of oral iodine-131 to treat thyroid cancer ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... thyroid dysfunction, and pituitary axis dysfunction.[7] Modern radiation therapy aims to reduce side effects to a minimum and ... severe thyroid eye disease, pterygium, pigmented villonodular synovitis, and prevention of keloid scar growth, vascular ...
Tse, G; Eslick, G.D. (2014). "Cruciferous vegetables and risk of colorectal neoplasms: a systematic review and meta-analysis". ... mainly as goitrogens and anti-thyroid agents) in both humans and animals[failed verification] at high doses.[9] However, ...
Other less common sites of origin include the prostate, kidney, thyroid, skin, colon and blood or bone marrow. ... Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Eye_neoplasm&oldid=895356793" ...
cystic neoplasms: Serous microcystic adenoma. *Intraductal papillary mucinous neoplasm. *Mucinous cystic neoplasm ...
It is made up of two lobes that meet in upper midline, that stretch from below the thyroid in the neck to as low as the ... ISBN 0-7020-2606-9. Huete-Garin, A.; S.S. Sagel (2005). "Chapter 6: "Mediastinum", Thymic Neoplasm". In J.K.T. Lee; S.S. Sagel ... 1985). "Thyroid Tumors Following Thymus Irradiation". J Natl Cancer Inst. 74 (6): 1177-1184. doi:10.1093/jnci/74.6.1177. PMID ... The arteries supplying the thymus are branches of the internal thoracic, and inferior thyroid arteries, with branches from the ...
甲狀腺癌(惡性):上皮細胞(英语:Thyroid epithelial cell)癌 *乳突性(英语:Papillary thyroid cancer) ... 腦垂腺(英语:Pituitary neoplasm). *垂體腺瘤(英语:Pituitary adenoma):泌乳素瘤(英语:Prolactinoma) ... 濾泡性(英语:Follicular thyroid cancer)/何氏細胞(英语:Hurthle cell)(嗜酸性濾泡細胞) ... 腫瘤:內分泌
Secondary neoplasm[edit]. Development of secondary neoplasia after successful chemotherapy or radiotherapy treatment can occur ... Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... The most common secondary neoplasm is secondary acute myeloid leukemia, which develops primarily after treatment with ... Survivors of childhood cancer are more than 13 times as likely to get a secondary neoplasm during the 30 years after treatment ...
This conclusion was reached based on the extent of absorption in humans and the incidence of neoplasms in rats in several ... studies where adult rats were found to have increased rates of tumours, including thyroid follicular cell hyperplasias, ...
... of thyroid cancers, 40%-90% of colorectal cancers and 50% of brain cancers. Promoter hypermethylation of LIG4 occurs in 82% of ... see malignant neoplasms). Thus, CpG island hyper/hypo-methylation in the promoters of DNA repair genes are likely central to ...
"Neoplasms and cancer" has been chosen to reflect the fact that not all tumours are benign. The word "cancer" has been included ...
Salivary gland neoplasms *Benign: Basal cell adenoma. *Canalicular adenoma. *Ductal papilloma. *Monomorphic adenoma ...
8560-8580) Complex epithelial neoplasms. Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that ... "Risk group-based management of differentiated thyroid carcinoma". J R Coll Surg Edinb. 46 (4): 216-23. PMID 11523714. Archived ... and imaging studies in a logical fashion to obtain information about the size of the neoplasm and the extent of its invasion ... or other notable characteristics consistent with a more highly differentiated neoplasm. ...
They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... Autopsy studies in Europe and Asia showed that up to 36% of people have undiagnosed and apparently harmless thyroid cancer at ... ovary and testis and also of thyroid cancer and bone cancer.[69] For example, the daughters of women who have breast cancer ... and thyroid cancer as well as other cancer types.[145] ...
Salivary gland neoplasms *Benign: Basal cell adenoma. *Canalicular adenoma. *Ductal papilloma. *Monomorphic adenoma ...
Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of function is ... Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes. Ligand. Growth factors. ...
en:Neoplasm (40) → 신생물 *en:Nephrotic syndrome (38) → 신증후군 *en:Nervous system disease (4) ... en:Thyroid disease (9). *en:Tianeptine (18) → 티아넵틴 *en:Tic (34). *en:Tobacco smoking (41) ...
Inskip PD., Thyroid cancer after radiotherapy for childhood cancer. Lühikokkuvõte., Med Pediatr Oncol. mai 2001 ;36(5):568-73 ... Tseng-Tong Kuo, Classification of thymic epithelial neoplasms: a controversial issue coming to an end?, J.Cell.Mol.Med. 5. ... Inskip PD., Thyroid cancer after radiotherapy for childhood cancer. Lühikokkuvõte., Med Pediatr Oncol. mai 2001 ;36(5):568-73 ... J. D. Boyd, Development of the Thyroid and Parathyroid Glands and the Thymus. Lecture delivered at the Royal College of ...
Horn, L; Lovly, CM; Johnson, DH (2015). "Chapter 107: Neoplasms of the lung". In Kasper, DL; Hauser, SL; Jameson, JL; Fauci, AS ... "Chest CT incidentalomas: thyroid lesions, enlarged mediastinal lymph nodes, and lung nodules". Cancer Imaging. 12 (1): 41-48. ... "Immunohistochemistry for Assessment of Pulmonary and Pleural Neoplasms: A Review and Update". Int J Clin Exp Pathol. 1 (1): 19 ...
Trophoblastic neoplasms derive from trophoblastic tissue. Examples include: *Choriocarcinoma. *Hydatidiform mole. Mechanism[ ...
Chapter 107: Neoplasms of the lung. (编) Kasper DL, Hauser SL, Jameson JL, Fauci AS, Longo DL, Loscalzo J. Harrison's Principles ... Chest CT incidentalomas: thyroid lesions, enlarged mediastinal lymph nodes, and lung nodules. Cancer Imaging. March 2012, 12 (1 ... Immunohistochemistry for Assessment of Pulmonary and Pleural Neoplasms: A Review and Update. Int J Clin Exp Pathol. 2008, 1 (1 ...
Salivary gland neoplasms *Benign: Basal cell adenoma. *Canalicular adenoma. *Ductal papilloma. *Monomorphic adenoma ...
Inhibit the release of thyroid-stimulating hormone (TSH). *Somatostatin suppresses the release of gastrointestinal hormones ... Glandular and epithelial neoplasms (ICD-O 8010-8589). Epithelium. Papilloma/carcinoma. (8010-8139). *Small cell carcinoma ...
I have had multi nodular thyroid for three years. The right lobe measures 5.6 cm.x 2.0 cm x 1.9 cm. Left lobe 5.2 cm x 2.0 clm ... Follicular Neoplasm. Cancer?. I have had multi nodular thyroid for three years. The right lobe measures 5.6 cm.x 2.0 cm x 1.9 ... I was also diagnosed w/ follicular neoplasm by FNA. 4 yrs ago I had an US of the thyroid which should multiple nodules on both ... I was also diagnosed w/ follicular neoplasm by FNA. 4 yrs ago I had an US of the thyroid which should multiple nodules on both ...
The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer". Thyroid. 26: 1- ... Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was ... Definition of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A noninvasive neoplasm that ... "Thyroid FNA cytology in Asian practice-Active surveillance for indeterminate thyroid nodules reduces overtreatment of thyroid ...
Thyroid Disorders. 7. 03-29-2005 09:03 AM. Follicular derived neoplasm....any help please? salty. Thyroid Disorders. 3. 06-03- ... Thyroid Disorders. 10. 08-12-2009 01:55 PM. Pathology Experts - Suspicious for Follicular Neoplasm? Nyxie63. Thyroid Disorders ... Thyroid Disorders Message Board HealthBoards , Endocrine , Thyroid Disorders > Follicular neoplasm/Hashis/Surgery ... Thyroid Disorders. 69. 02-28-2006 11:26 AM. surgery Monday, follicular cells, HELP!!! tadla. Thyroid Disorders. 35. 10-31-2005 ...
"Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer ... Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm. Chutintorn Sriphrapradang,1 ... "Palpable parathyroid adenomas presenting as clinical solitarythyroid nodules and cytologically as follicular thyroid neoplasms ... Thyroid, vol. 19, no. 11, pp. 1167-1214, 2009. View at Publisher · View at Google Scholar · View at Scopus ...
Thyroid neoplasm is a neoplasm or tumor of the thyroid. It can be a benign tumor such as thyroid adenoma, or it can be a ... Thyroid adenoma is a benign neoplasm of the thyroid. Thyroid nodules are very common and around 80 percent of adults will have ... Thyroid nodules are a major presentation of thyroid neoplasms, and are diagnosed by ultrasound guided fine needle aspiration ( ... Other thyroid malignancies include thyroid lymphoma, various types of thyroid sarcoma, smooth muscle tumors, teratoma, squamous ...
PubMed journal article The surgical dilemma of primary surgery for follicular thyroid neoplasm were found in PRIME PubMed. ... Follicular thyroid carcinoma is the second most prevalent form of differentiated thyroid carcinoma, following papillary thyroid ... follicular thyroid carcinoma KW - follicular thyroid neoplasm KW - guidelines KW - thyroidectomy KW - treatment recommendations ... The Surgical Dilemma of Primary Surgery for Follicular Thyroid Neoplasms. Best Pract Res Clin Endocrinol Metab. 2019;33(4): ...
Tag: noninvasive follicular thyroid neoplasm with papillary-like nuclear features. CancerPolitics and RegulationPublic Health ... Reclassifying thyroid cancer and the willful misunderstanding of overdiagnosis. If theres one lesson that we here at Science- ...
FNAB of thyroid masses is useful in diagnosis of thyroid metastases; this, however, requires information about the nonthyroid ... Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon [14, 15]. In the present case, the identification of ... metastases to the thyroid are more common in women than men (female to male ratio, 1.4 : 1) and in nodular thyroid glands (44.2 ... and a thyroidectomy was performed in order to rule out a primary thyroid neoplasm. ...
"Thyroid Neoplasms" by people in this website by year, and whether "Thyroid Neoplasms" was a major or minor topic of these ... "Thyroid Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Thyroid Neoplasms" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Thyroid Neoplasms". ...
Thyroid carcinomas encompass a wide spectrum ranging from well-differentiated thyroid carcinomas to poorly differentiated and ... papillary thyroid carcinoma and anaplastic thyroid carcinoma. Larger studies and/or meta-analyses could further delineate their ... exists in the morphological diagnosis of certain types of thyroid carcinomas especially the follicular pattern neoplasm. The ... Several investigators have proposed a more cohesive approach to thyroid cancer diagnosis incorporating molecular and proteomics ...
Table 2: Misclassified malignant neoplasms of the thyroid: Rarity of tumors Case #. Age/ Gender. Cytologic diagnosis. ... Table 3: Misclassified malignant neoplasms of the thyroid: Inadequate sampling Case #. Age/ gender. Cytologic diagnosis. ... Table 1: Misclassified malignant neoplasms of the thyroid: Overlapping cytological features Case #. Age/ gender. Cytologic ... and poorly differentiated thyroid carcinomas and medullary thyroid carcinoma, anaplastic thyroid carcinomas, unless small and ...
The paper summarizes the features of adenomas and carcinomas of the thyroid gland in dogs. Only the Boxer breed was ... Thyroid neoplasms in the dog. A clinicopathologic study of fifty-seven cases.. @article{Brodey1968ThyroidNI, title={Thyroid ... Non-functional thyroid cystadenoma in three boxer dogs. Marie-Pauline Maurin, Dan Davies, Hanne Jahns, Robert E. Shiel, Carmel ... Follicular-Compact-Cellular Carcinoma in the Thyroid Gland of a Dog. Ayhan Atasever, Yücel Cam, Fatma Uyanik ...
Thyroid gland Thyroid Gland Thyroid Neoplasms Endocrinology & Metabolism MEDICAL / Endocrinology & Metabolism sähkökirjat ... Follicular variant of papillary thyroid carcinoma.. Papillary thyroid carcinoma.. Medullary thyroid carcinoma.. Anaplastic ... Ultrasound features of thyroid lesions.. Nodular or colloid goiter, hyperplasia, and cysts.. Follicular adenoma and follicular ... thyroid carcinoma.. Oncocytic nodule/Hurtle cell tumors. ...
... is a very rare neoplasm related to the thyroid of young individuals. In 1991, Chan and Rosai unified the co.. ... thyroid, thyroid spindle cell tumor with mucous cysts or thyroid thymoma [1]. SETTLE is a distinct low-grade neoplasm, believed ... thyroid spindle cell tumor with mucous cysts or thyroid thymoma. SETTLE is a distinct low-grade neoplasm, believed to be ... SETTLE; Sarcoma; Thyroid. Introduction. The spindle epithelial tumor with thymus-like element (SETTLE) is a very rare neoplasm ...
THYROID- NEOPLASM flashcards from Maria Hazel Quiban ... Flashcards in ENDOC- THYROID- NEOPLASM Deck (0) Loading ...
... is an important tool for evaluating thyroid nodules although up to 20% of cases may result in an indetermin... ... BRAF-1 and N-RAS mutation analysis identifies malignant follicular thyroid neoplasm?s on liquid-based cytology. 2nd ... BRAF, RET/PTC or N-Ras mutations are referred as markers of malignancy for papillary carcinoma (PTC), the most common thyroid ... Objectives: Fine needle aspiration cytology (FNAC) is an important tool for evaluating thyroid nodules although up to 20% of ...
... alternative as compared with conventional open thyroidectomy in patients with a small thyroid cancer or a benign thyroid tumor ... The authors suggest that a smaller follicular neoplasm is a good indication for endoscopic thyroidectomy, but that a large ... Recently, the authors experienced a case of follicular thyroid cancer recurrence that developed around the operative bed and ... alternative as compared with conventional open thyroidectomy in patients with a small thyroid cancer or a benign thyroid tumor ...
"Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Did We Trade Six for a Half a Dozen?, ... 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid ... Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Did We Trade Six for a Half a Dozen?. ... Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Did We Trade Six for a Half a Dozen?. ...
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Endocr Relat Cancer. 2016;23:893-7. CrossRef ... Thyroid lobectomy is not sufficient for T2 papillary thyroid cancers. Surgery. 2018;163:1134-43. CrossRefPubMed ... Impact of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) on the Outcomes of Lobectomy. ... Noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Endocr Relat Cancer. 2016;23:893-7. ...
If your institution subscribes to this resource, and you dont have a MyAccess Profile, please contact your librarys reference desk for information on how to gain access to this resource from off-campus. OK ...
The paper summarizes the features of adenomas and carcinomas of the thyroid gland in dogs. Only the Boxer breed was ... Thyroid neoplasms in the dog. A clinicopathologic study of fifty-seven cases. by Heather Hill , posted in: Thyroid Thoughts , 0 ... The paper summarizes the features of adenomas and carcinomas of the thyroid gland in dogs. Only the Boxer breed was ...
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): Trading Six for a Risky Half Dozen: Reply ... Paper: Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): Trading Six for a Risky Half Dozen ...
... , we or us ) is the member to occur this inspiration validation at any recipe even by increasing ... Thyroid Neoplasms 2006. * save them create websites to identify it their innovative Thyroid Neoplasms or you can please it ... We have Thyroid Neoplasms 2006 about you when you register on one of our users. When you do a book or dam device that does ... We may be Thyroid Neoplasms erased from you through few orders or at other brands and please demographic pre-cut along with ...
"Thyroid Neoplasms" by people in this website by year, and whether "Thyroid Neoplasms" was a major or minor topic of these ... State-of-the-art thyroid surgical recommendations in the era of noninvasive follicular thyroid neoplasm with papillary-like ... "Thyroid Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Noninvasive Follicular Thyroid Neoplasms With Papillary-like Nuclear Features Are Genetically and Biologically Similar to ...
"Thyroid Neoplasms" by people in UAMS Profiles by year, and whether "Thyroid Neoplasms" was a major or minor topic of these ... "Thyroid Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Thyroid Neoplasms" by people in Profiles over the past ten years. ... Encapsulated papillary oncocytic neoplasms of the thyroid: morphologic, immunohistochemical, and molecular analysis of 18 cases ...
Classification of thyroid neoplasms. WHO classification of thyroid tumours (1988). I. Epiteliální tumory ...
Classification of thyroid neoplasms. WHO classification of thyroid tumours (1988). I. Epithelial tumours. *Benign *Follicular ...
  • Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was previously classified as an encapsulated follicular variant of papillary thyroid carcinoma, necessitating a new classification as it was recognized that encapsulated tumors without invasion have an indolent behavior, and may be over-treated if classified as a type of cancer. (wikipedia.org)
  • Definition of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A noninvasive neoplasm that arises from the thyroid follicular cells (cells that normally make thyroid hormone), showing a predominantly follicular growth pattern and with nuclear features of papillary thyroid carcinoma. (wikipedia.org)
  • Abbreviations: NIFTP: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features EFVPTC: Encapsulated follicular variant of papillary thyroid carcinoma. (wikipedia.org)
  • PTC: Papillary thyroid carcinoma. (wikipedia.org)
  • Follicular thyroid carcinoma is the second most prevalent form of differentiated thyroid carcinoma, following papillary thyroid carcinoma. (unboundmedicine.com)
  • Preoperative diagnosis is hampered by the fact that fine-needle aspiration cytology as well as supplemental molecular analysis cannot unambiguously distinguish between follicular thyroid carcinoma and benign follicular thyroid adenoma. (unboundmedicine.com)
  • The 2017 WHO classification defines three histological subtypes of follicular thyroid carcinoma: minimally invasive (excellent prognosis), encapsulated angioinvasive, and widely invasive type (higher risk of recurrence and metastatic spread). (unboundmedicine.com)
  • AU - Staubitz,Julia I, AU - Musholt,Petra B, AU - Musholt,Thomas J, Y1 - 2019/07/09/ PY - 2019/8/23/pubmed PY - 2019/8/23/medline PY - 2019/8/23/entrez KW - completion thyroidectomy KW - follicular thyroid carcinoma KW - follicular thyroid neoplasm KW - guidelines KW - thyroidectomy KW - treatment recommendations SP - 101292 EP - 101292 JF - Best practice & research. (unboundmedicine.com)
  • Other thyroid malignancies include thyroid lymphoma, various types of thyroid sarcoma, smooth muscle tumors, teratoma, squamous cell thyroid carcinoma and other rare types of tumors. (wikipedia.org)
  • Clear cell renal cell carcinoma (CCRCC) is the most common origin for metastasis in the thyroid. (hindawi.com)
  • Mapping the distribution of nodal metastases in papillary thyroid carcinoma: Where exactly are the nodes? (umassmed.edu)
  • Lateral neck dissection for well-differentiated thyroid carcinoma: a systematic review. (umassmed.edu)
  • Moghaddam PA, Cornejo KM, Khan A. Metastatic carcinoma to the thyroid gland: a single institution 20-year experience and review of the literature. (umassmed.edu)
  • Thyroid carcinomas encompass a wide spectrum ranging from well-differentiated thyroid carcinomas to poorly differentiated and anaplastic carcinoma. (bmj.com)
  • In this context, miRNAs serve as an important diagnostic tool, and several studies have demonstrated their utility as class identifiers especially in the context of follicular thyroid carcinoma, papillary thyroid carcinoma and anaplastic thyroid carcinoma. (bmj.com)
  • Clinical data, FNA smears and follow-up surgical specimens of cases diagnosed with primary thyroid carcinoma were reviewed. (cytojournal.com)
  • Two cases of undifferentiated (anaplastic) thyroid carcinoma were misdiagnosed as papillary thyroid carcinoma. (cytojournal.com)
  • However, initial cytologic misclassification of medullary carcinoma or undifferentiated carcinoma as other malignant neoplasms or vice versa may have an impact on clinical management. (cytojournal.com)
  • The most common thyroid cancers diagnosed by FNA are papillary thyroid carcinoma, followed by follicular carcinoma, medullary thyroid carcinoma, undifferentiated carcinoma, and poorly differentiated carcinoma. (cytojournal.com)
  • Follicular adenoma and follicular thyroid carcinoma. (helsinki.fi)
  • Follicular variant of papillary thyroid carcinoma. (helsinki.fi)
  • Medullary thyroid carcinoma. (helsinki.fi)
  • BRAF, RET/PTC or N-Ras mutations are referred as markers of malignancy for papillary carcinoma (PTC), the most common thyroid malignancy. (omicsonline.org)
  • Clinical safety of renaming encapsulated follicular variant of papillary thyroid carcinoma: is NIFTP truly benign? (deepdyve.com)
  • Cribriform-Morular Variant of Papillary Thyroid Carcinoma With Poorly Differentiated Features: A Case Report With Immunohistochemical and Molecular Genetic Analysis. (uchicago.edu)
  • Murshed K, Al-Bozom I, Vattoth S, Akhtar M. Mediastinal seminoma presenting as a neck mass falsely diagnosed as anaplastic thyroid carcinoma: A case report. (uams.edu)
  • Concurrent metastases of papillary thyroid carcinoma to the scalp and Meckel's cave. (uams.edu)
  • The aim of this study was to determine whether pathologists could distinguish BRAF -like and RAS -like nuclear features morphologically and identify morphological features to differentiate thyroid tumors with RAS -like mutations from encapsulated papillary thyroid carcinoma (PTC) with predominant follicular growth and BRAF V600E mutation. (e-enm.org)
  • The renaming of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was proposed by a group of experts in 2016 to prevent overtreatment of indolent, low-risk thyroid cancers. (sparrho.com)
  • Our cohort consisted of 134 patients with papillary thyroid carcinoma from the Region of Southern Denmark (RSD), 2007 to 2011. (sparrho.com)
  • Rare breast neoplasms resembling the tall-cell variant of papillary thyroid carcinoma have been reported. (nature.com)
  • In addition, papillary carcinoma of the breast occasionally displays nuclear features reminiscent of papillary thyroid carcinoma. (nature.com)
  • In this study, we evaluated 33 intraductal/intracystic papillary carcinomas of the breast for the presence and extent of nuclear overlap, grooves, clearing, and inclusions, as well as features of the tall-cell or columnar-cell variants of papillary thyroid carcinoma. (nature.com)
  • Although papillary carcinomas of breast often display one or more cytoarchitectural features of papillary thyroid carcinoma, there is no evidence that RET rearrangements are involved. (nature.com)
  • Given their resemblance to one of the variants of papillary thyroid carcinoma (which was excluded by both clinical and immunohistochemical means), such cases were referred to as 'breast tumor resembling the tall-cell variant of papillary thyroid carcinoma. (nature.com)
  • 5 , 6 In addition to displaying nuclear features characteristic of papillary thyroid carcinoma, all 10 reported cases had unequivocal papillary areas, and most displayed evidence of an in situ component and/or had foci surrounded at the periphery by a myoepithelial cell layer as determined morphologically or by immunohistochemistry. (nature.com)
  • If this were the case, one might expect that such features need not be limited to cases of 'breast tumor resembling the tall-cell variant of papillary thyroid carcinoma', but may be common to papillary carcinomas of the breast in general. (nature.com)
  • 1. Parente DN , Kluijfhout WP , Bongers PJ et al ( 2017 ) Clinical safety of renaming encapsulated follicular variant of papillary thyroid carcinoma: is NIFTP truly benign? (paperity.org)
  • 14 (58 %) of the malignant cases were papillary thyroid carcinoma. (nih.gov)
  • Sensitivity of NCB for diagnosing papillary carcinoma (PC) and follicular neoplasm was calculated at 0.88 (0.47-1.0, 95 % CI) and 0.84 (0.60-0.97, 95 % CI), respectively. (nih.gov)
  • Thus far, the behaviour of PLZF in thyroid carcinoma remains unclear. (biomedcentral.com)
  • Furthermore, high cytoplasmic expression of PLZF may be correlated with CI and LN metastasis in thyroid carcinoma. (biomedcentral.com)
  • The majority of patients with thyroid carcinoma who undergo appropriate treatment have an excellent outcome. (biomedcentral.com)
  • With regard to thyroid carcinoma, there have been no reports describing the possible involvement of PLZF expression and its function. (biomedcentral.com)
  • Since no diagnostic method has been established to distinguish follicular thyroid carcinoma (FTC) from follicular thyroid adenoma (FTA), surgery has been the only way to reach a diagnosis of follicular neoplasm. (okayama-u.ac.jp)
  • I. Determine the 1-year treatment failure rate in patients with inoperable locoregionally advanced or metastatic medullary or differentiated thyroid carcinoma treated with 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) (tanespimycin). (clinicaltrials.gov)
  • Patients are stratified according to type of thyroid carcinoma (medullary vs differentiated). (clinicaltrials.gov)
  • Moreover, the presence of mature fat tissue has been described in only one case of thyroid carcinoma (papillary subtype). (houstonmethodist.org)
  • We describe one case of thyrolipoma and one case of fat containing follicular carcinoma of the thyroid, and we reviewed the literature on the presence of adipose tissue in the thyroid. (houstonmethodist.org)
  • However key epithelial-to-mesenchymal transition (EMT) markers including E-cadherin and vimentin as well as Slug were not affected by cyclopamine and GANT61 in either SW1736 or WRO82 a well differentiated follicular thyroid carcinoma RO5126766 cell collection. (biosweepny.com)
  • This study compares clinical, histologic, and molecular features of patients with AAs (n=31), nonmetastatic follicular thyroid carcinoma (nmFTC) (n=18), and metastatic follicular thyroid carcinoma (mFTC) (n=38). (lab.equipment)
  • These tumors are compared and contrasted with non-epithelial-derived tumors such as paraganglioma and nonmucosal tumors, such as medullary thyroid carcinoma. (nih.gov)
  • The newly proposed nomenclature and diagnostic criteria for encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), the noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), could improve the consistency and accuracy of diagnosing this entity. (cdc.gov)
  • The predictive factors for carcinoma shown by the chi-square test were: sex, thyroid volume, and preoperative Tg concentration. (biomedcentral.com)
  • The cytology diagnosis of these cases was papillary carcinoma (25), follicular neoplasm (16), adenomatous goiter (20), hyperplastic nodule (5), medullary carcinoma (5) and anaplastic carcinoma (1). (bvsalud.org)
  • Three of thefollicular neoplasms that were diagnosed on histology as carcinoma were positive on cytology and one case offollicular adenoma was also positive. (bvsalud.org)
  • Solid papillary breast carcinoma resembling the tall cell variant of papillary thyroid neoplasms (BPTC), also known as solid papillary carcinoma with reverse polarity, is a rare histological type of breast cancer that resembles morphologically the tall cell variant of papillary thyroid carcinoma. (cdc.gov)
  • Aim To identify ultrasonographic characteristics associated to papillary thyroid carcinoma (PTC) and generate a score that predicts the risk of PTC. (scielo.cl)
  • Asari R, Koperek O, Scheuba C, Riss P, Kaserer K, Hoffmann M. Follicular thyroid carcinoma in an iodine-replete endemic goiter region: a prospectively collected, retrospectively analyzed clinical trial. (medscape.com)
  • NCCN guidelines in oncology: thyroid carcinoma.Version 2.2015. (umm.edu)
  • INTRODUCTION: Papillary carcinoma is the most common malignant thyroid tumor and its incidence has been increasing around the world in recent decades. (usp.br)
  • The aim os this study is to analyse the immunohistochemical expression of selected markers (Cytokeratin-19, Galectin-3, EGFR, Ki 67, NF-kB) as predictors of thyroid papillary carcinoma recurrence. (usp.br)
  • METHODS: Retrospective case-control study, which included 42 cases of patients with papillary thyroid carcinoma surgically treated at the A.C.Camargo Cancer Center between January 2000 and July 2010. (usp.br)
  • citation needed] The clinical presentation of the patients is identical to other thyroid tumors, where there is usually a painless, asymptomatic, mobile thyroid gland nodule or enlargement. (wikipedia.org)
  • Most tumors are seen in just one lobe of the thyroid gland (unifocal), but multicentric tumors (same lobe or opposite lobe) can be seen in up to 38% of cases. (wikipedia.org)
  • Hyperthyroidism and hypothyroidism are two conditions that often arise from an abnormally functioning thyroid gland. (wikipedia.org)
  • Whole-body fluorodeoxyglucose positron emission tomography revealed elevated values in the thyroid gland, while the mediastinum was normal. (hindawi.com)
  • Here, we present a case of recurrent CCRCC, with metastases to both the mediastinal lymph nodes and the thyroid gland 10 years after nephrectomy. (hindawi.com)
  • Tumors or cancer of the THYROID GLAND. (umassmed.edu)
  • Cytologic diagnosis of metastatic alveolar rhabdomyosarcoma to the thyroid gland by fine-needle aspiration. (umassmed.edu)
  • The paper summarizes the features of adenomas and carcinomas of the thyroid gland in dogs. (semanticscholar.org)
  • A benign neoplasm arising from the thyroid gland. (icd10data.com)
  • Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. (icdlist.com)
  • There are several types of cancer of the thyroid gland. (icdlist.com)
  • The cell origins of ten anaplastic small cell neoplasms of the thyroid gland were investigated using the immunoperoxidase technique. (utmb.edu)
  • Primary mesenchymal tumors of the thyroid gland are extremely rare. (ufrgs.br)
  • Thus the diagnosis of primary osteosarcoma of the thyroid gland was established. (ufrgs.br)
  • C74.0 Malignant neoplasm of cortex of adrenal gland. (icd-code.org)
  • C75.9 Malignant neoplasm of endocrine gland, unspec. (icd-code.org)
  • Fine needle aspiration of the thyroid gland is a procedure to remove thyroid cells for examination. (medlineplus.gov)
  • The thyroid gland is a butterfly-shaped gland located inside the front of the lower neck. (medlineplus.gov)
  • The main risk is bleeding into or around the thyroid gland. (medlineplus.gov)
  • Fine-needle aspiration of the thyroid gland: The 2017 Bethesda System. (medlineplus.gov)
  • Surgeon's approach to the thyroid gland: surgical anatomy and the importance of technique. (medscape.com)
  • Thyroid neoplasm or thyroid cancer usually refers to any of four kinds of malignant tumors of the thyroid gland: papillary, follicular, medullary or anaplastic. (medicalxpress.com)
  • Medullary tumors have a good prognosis if restricted to the thyroid gland and a poorer prognosis if metastasis occurs. (medicalxpress.com)
  • The thyroid gland is usually palpable in the midline below the thyroid cartilage. (aafp.org)
  • Thyroid peroxidase (TPO) is essential for physiological function of the thyroid gland. (bioportfolio.com)
  • 1. Hürthle cells are seen in a variety of nonneoplastic and neoplastic thyroid gland lesions. (thyroidnosurgery.com)
  • It has a nodular texture because it is actually composed of numerous thyroid nodules the margins of which are difficult to differentiate from one another. (medhelp.org)
  • The l. lobe contains several thyroid nodules some of which are isoechoic with adjacent tissue whereas others are hypoechoic. (medhelp.org)
  • All that I have seen say that the term follicular lesion is applied to all nodules because the thyroid produces follicular cells! (healthboards.com)
  • Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer," Thyroid , vol. 19, no. 11, pp. 1167-1214, 2009. (hindawi.com)
  • Parathyroid incidentalomas detected on routine ultrasound-directed fine-needle aspiration biopsy in patients referred for thyroid nodules and the role of parathyroid hormone analysis in the samples," Thyroid , vol. 19, no. 7, pp. 743-748, 2009. (hindawi.com)
  • Of all thyroid nodules discovered, only about 5 percent are cancerous, and under 3 percent of those result in fatalities. (wikipedia.org)
  • Thyroid nodules are a major presentation of thyroid neoplasms, and are diagnosed by ultrasound guided fine needle aspiration (USG/FNA) or frequently by thyroidectomy (surgical removal and subsequent histological examination). (wikipedia.org)
  • Thyroid nodules are very common and around 80 percent of adults will have at least one by the time they reach 70 years of age. (wikipedia.org)
  • Fine needle aspiration (FNA) cytology is a reliable and economical initial test for the diagnosis of thyroid nodules, both benign and malignant. (cytojournal.com)
  • Objectives: Fine needle aspiration cytology (FNAC) is an important tool for evaluating thyroid nodules although up to 20% of cases may result in an indeterminate diagnosis (Follicular Neoplasm - FN) which is a challenge also for expert cytopathologists. (omicsonline.org)
  • Wheat germ agglutinin (WGA) and concanavalin A bind to benign and malignant thyroid nodules. (greenmedinfo.com)
  • Thyroid nodules are frequent in general population, found in 3.7-7% of people by palpation and 42-67% by ultrasonography (US). (intechopen.com)
  • Cancer risk in thyroid nodules varies: 5% in masses found by palpation, 1.6-15% by US, 3.9-11.3% by computed tomography (CT), 5-6% by magnetic resonance imaging (MRI) and 30-50% by positron emission tomography (PET). (intechopen.com)
  • The aim of this chapter is to review classic and innovative histopathology of thyroid nodules for diagnostic pathology practice and research in multidisciplinary thyroid teams. (intechopen.com)
  • Thyroid nodules represent an extremely frequent finding in the general population [ 1 ] and therefore enter the spectrum of the most common diagnostic dilemmas in endocrine surgery, cytology and surgical pathology. (intechopen.com)
  • Three quarters of palpable nodules are solitary [ 3 ], raising increased suspicion of neoplasm. (intechopen.com)
  • By ultrasonography (US), thyroid nodules can be disclosed even more frequently: in 42-67% of patients, and other radiological investigations also yield incidental nodules in a significant proportion of cases [ 2 , 4 , 5 , 6 ] as shown in Table 1 . (intechopen.com)
  • Our institution routinely utilizes needle core biopsy (NCB), instead of fine needle aspiration, in the evaluation of pediatric thyroid nodules. (nih.gov)
  • The remaining 67 patients had one or more thyroid nodules as identified by ultrasound. (nih.gov)
  • The Japan Thyroid Association recently published guidelines for clinical practice for the management of thyroid nodules, which include a diagnostic system for reporting thyroid fine needle aspiration cytology. (elsevier.com)
  • However No More Than 25% Of These Nodules Are Confirmed To Be Thyroid Cancer Which Means That 75% Of the Patients Underwent Unnecessary Surgery. (corfo.cl)
  • It is often used to find out if thyroid nodules that your provider can feel or seen on an ultrasound are noncancerous or cancerous. (medlineplus.gov)
  • Serum thyroglobulin (Tg) concentrations are higher in follicular and Hürthle cell carcinomas than in benign follicular or Hürthle cell tumors, but preoperative measurement of Tg is not recommended for initial evaluation of thyroid nodules. (biomedcentral.com)
  • This study was conducted to study the role of galectin-3 in differentiating benign from malignant thyroid nodules onfine needle aspirates (FNAC). (bvsalud.org)
  • Galectin-3 positivity was seen in 80% of papillary carcinomas , 37.5% offollicular neoplasms and in 60% of benign nodules. (bvsalud.org)
  • However, since it is also expressed in a variety of benign lesions, its role as a pre-surgical markerfor differentiating benignfrom malignant thyroid nodules is limited. (bvsalud.org)
  • DESIGN: Fine-needle aspiration biopsy (FNAB) is the most reliable diagnostic tool in the diagnosis of thyroid nodules. (unicatt.it)
  • Thyroid nodules are common and associated to a low risk of malignancy. (scielo.cl)
  • 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. (medscape.com)
  • Cancer risk in patients with cold thyroid nodules: relevance of iodine intake, sex, age, and multinodularity. (medscape.com)
  • Dysbiosis of the gut microbiome is associated with thyroid cancer and thyroid nodules and correlated with clinical index of thyroid function. (bioportfolio.com)
  • Thyroid cancer and thyroid nodules are the most prevalent form of thyroid endocrine disorder. (bioportfolio.com)
  • Aim To evaluate thyroid nodules and to determine the incidence of thyroid cancer. (bioportfolio.com)
  • Methods This retrospective cohort study collected data from ten patients who presented with thyroid nodules to Barrin. (bioportfolio.com)
  • RATIONALE: Gathering information about patients with thyroid cancer or thyroid nodules may help the study of thyroid cancer in the future. (bioportfolio.com)
  • Preoperative Molecular Markers in Thyroid Nodules. (nih.gov)
  • 118 patients (119 nodules) with NIFTP and available preoperative thyroid FNA were included. (elsevier.com)
  • The SETTLE is among four tumors related to the thyroid, easily differentiated by clinicpathologic correlation. (omicsonline.org)
  • 1] reported 5% of lymph node ''when defined with strict histopathologic criteria, these metastases and 1% of distant metastases in 102 patients tumors are not expected to show molecular alterations V600E with ''noninvasive follicular thyroid neoplasm with papil- associated with classic PTC, such as BRAF muta- lary-like nuclear features'' (NIFTP). (deepdyve.com)
  • Representative whole slide images of 16 encapsulated thyroid tumors with predominant follicular growth were reviewed by 12 thyroid pathologists using a web browser-based image viewer. (e-enm.org)
  • Encapsulated follicular-patterned thyroid tumors are commonly encountered in thyroid cytopathology/histopathology practice. (e-enm.org)
  • Aburjania Z , Jang S , Montemayor-Garcia C et al ( 2017 ) Encapsulated follicular variant of papillary thyroid cancer: are these tumors really benign? (paperity.org)
  • The new 2017 World Health Organization (WHO) classification of thyroid neoplasms updated the diagnostic criteria and molecular and genetic characteristics reflecting the biology and behavior of the tumors, and newly introduced the category of borderline malignancy or uncertain malignant potential. (e-enm.org)
  • This review introduces changes in the fourth edition WHO classification of thyroid tumors and updates the contemporary diagnosis and classification of thyroid tumors. (e-enm.org)
  • A histopathological classification of neoplasms reflects the biology and behavior of the tumors and serves as a guide for doctors and clinical management of patients. (e-enm.org)
  • Aside from the presence of mature fat tissue, the clinicopathologic features of fat containing thyroid tumors are not different from those of their usual counterparts. (houstonmethodist.org)
  • Galectin-3 is a 31kD beta-galactoside binding lectin , which is known to be expressed in various neoplasms including thyroid tumors . (bvsalud.org)
  • Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain. (unil.ch)
  • Adjacent to the r. margin of the isthmus there is a solid 2.9 cm thyroid nodule. (medhelp.org)
  • Treatment of a thyroid nodule depends on many things including size of the nodule, age of the patient, the type of thyroid cancer, and whether or not it has spread to other tissues in the body. (wikipedia.org)
  • If the nodule is benign, patients may receive thyroxine therapy to suppress thyroid-stimulating hormone and should be reevaluated in 6 months. (wikipedia.org)
  • Impact of thyroid nodule size on prevalence and post-test probability of malignancy: a systematic review. (umassmed.edu)
  • Angelos P. The Problem of the Indeterminate Thyroid Nodule: A Genomic Sequencing Classifier and Clinical Judgment. (uchicago.edu)
  • 46 of the thyroid nodule cases underwent pre-operative NCB. (nih.gov)
  • Objective: When a fine needle aspiration biopsy of a thyroid nodule suggests follicular neoplasm, surgery is required for diagnosis. (nebraska.edu)
  • A Simple Test That Uses a Small Sample Of the Fine Needle Aspirate That Allows Performing a Molecular Profile Of the Thyroid Nodule Prior To Surgery. (corfo.cl)
  • The Molecular Profile Will More Accurately Indicate the Risk Of Malignancy Of the Thyroid Nodule Reported As a Follicular Neoplasms. (corfo.cl)
  • It Should Be Used In Patients Undergoing a Diagnostic Workup Of a Thyroid Nodule so It Will Be Possible To Identify Patients That Truly Need Surgery And More Importantly Avoid Surgery In Patients That Do Not Require It. (corfo.cl)
  • Participants in this study will be patients diagnosed with or suspected to have a thyroid nodule or thyroid cancer. (bioportfolio.com)
  • Thyroid Nodule Diagnostic Markers in the Face of the New NIFTP Category: Time for a Reset? (nih.gov)
  • When is A Thyroid nodule with Hurthle cells not a neoplasm but part of a chronic thyroidits? (thyroidnosurgery.com)
  • It can be a benign tumor such as thyroid adenoma, or it can be a malignant neoplasm (thyroid cancer), such as papillary, follicular, medullary or anaplastic thyroid cancer. (wikipedia.org)
  • citation needed] Thyroid adenoma is a benign neoplasm of the thyroid. (wikipedia.org)
  • The thyroidectomy specimen also revealed lymphocytic thyroiditis, nodular hyperplasia, one follicular adenoma, two papillary microcarcinomas, and six foci of metastatic CCRCC involving both thyroid lobes. (hindawi.com)
  • Thyrolipoma or adenolipoma of the thyroid, defined as a thyroid adenoma containing mature fat tissue, is rare and has been reported only seven times. (houstonmethodist.org)
  • In follicular thyroid neoplasms without invasion, a diagnosis of atypical adenoma (AA) (follicular tumor of uncertain malignant potential) may be rendered if atypical features (indefinite capsular/vascular invasion, necrosis, solid growth, increased mitoses) are present. (lab.equipment)
  • As thyroid cancer can take up iodine, radioactive iodine is commonly used to treat thyroid carcinomas, followed by TSH suppression by high-dose thyroxine therapy. (wikipedia.org)
  • Currently, a considerable degree of interobserver variability exists in the morphological diagnosis of certain types of thyroid carcinomas especially the follicular pattern neoplasm. (bmj.com)
  • The flip side of NIFTP: an increase in rates of unfavorable histologic parameters in the remainder of papillary thyroid carcinomas. (springermedizin.de)
  • Six neoplasms were identified as malignant lymphomas, and two were identified as anaplastic small cell follicular carcinomas. (utmb.edu)
  • The present report is the first to describe the implications of intracellular PLZF expression in thyroid carcinomas. (biomedcentral.com)
  • Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (solid papillary carcinomas with reverse polarity. (cdc.gov)
  • Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (solid papillary carcinomas with reverse polarity) harbour recurrent mutations affecting IDH2 and PIK3CA: a validation cohort. (cdc.gov)
  • Until improved tools for pre-/intraoperative diagnosis are available, the malignant potential of a follicular thyroid lesion can be assessed by stratifying the patient according to clinical risk factors (presence of metastases, advanced patient age, tumor size). (unboundmedicine.com)
  • Thyroid neoplasm is a neoplasm or tumor of the thyroid. (wikipedia.org)
  • Encapsulation status of papillary thyroid microcarcinomas is associated with the risk of lymph node metastases and tumor multifocality. (umassmed.edu)
  • The spindle epithelial tumor with thymus-like element (SETTLE) is a very rare neoplasm related to the thyroid of young individuals. (omicsonline.org)
  • In 1991, Chan and Rosai unified the concept of SETTLE when they described 8 neoplasms situated in the neck and thyroid of children and young adults, previously diagnosed as malignant teratoma of the thyroid, thyroid spindle cell tumor with mucous cysts or thyroid thymoma. (omicsonline.org)
  • Endoscopic thyroidectomy is a safe and feasible alternative as compared with conventional open thyroidectomy in patients with a small thyroid cancer or a benign thyroid tumor. (ovid.com)
  • Zurück zum Zitat Gartland RM, Lubitz CC. Impact of extent of surgery on tumor recurrence and survival for papillary thyroid cancer patients. (springermedizin.de)
  • CT scan demonstrated a large tumor in the right thyroid lobe with areas of calcification. (ufrgs.br)
  • The sonic hedgehog (Shh) pathway is highly activated in thyroid neoplasms and promotes thyroid cancer stem-like cell phenotype but whether the Shh pathway regulates thyroid tumor cell motility and invasiveness remains unknown. (biosweepny.com)
  • Our data suggest that the Shh pathway-stimulated thyroid tumor cell RO5126766 motility and invasiveness is largely mediated by AKT and c-Met activation with little involvement of EMT. (biosweepny.com)
  • The presence of tumor invasion in follicular thyroid neoplasms with papillary-like nuclear features has been recently discussed by many authors. (cdc.gov)
  • The surgically resected specimens of various histological types of thyroid tumor , from the files of the Dept. of surgery , Chung-Ang University Pil-Dong Hospital , between January 1998 and June 2002 were reviewed, and 55 cases selected for immunohistochemical studies. (bvsalud.org)
  • From 1988 to 2013, a total of 244 patients (214 female, 30 male, age range 9 to 82 years, median age 52 years) had a surgical procedure at our institute because of follicular or Hürthle cell neoplasms with a tumor diameter of 2 cm or less. (biomedcentral.com)
  • Una resonancia magnética o una tomografía computarizada del cuello pueden mostrar un tumor en crecimiento a partir de la glándula tiroides. (umm.edu)
  • Consulte con el médico si hay un tumor o masa persistente en el cuello, ronquera, cambios en la voz, tos o expectoración de sangre. (umm.edu)
  • The majority of primary malignant neoplasms diagnosed on FNA require thyroidectomy. (cytojournal.com)
  • Recently, the authors experienced a case of follicular thyroid cancer recurrence that developed around the operative bed and along the port insertion site after endoscopic thyroidectomy for a large follicular neoplasm. (ovid.com)
  • The authors suggest that a smaller follicular neoplasm is a good indication for endoscopic thyroidectomy, but that a large follicular neoplasm should not be viewed as indicators for endoscopic surgery, because of the possibility of malignancy and rupture during manipulation. (ovid.com)
  • We performed a single institution retrospective chart review of all children who underwent thyroidectomy for primary thyroid pathology. (nih.gov)
  • Overall and cause-specific survival for patients undergoing lobectomy, near-total, or total thyroidectomy for differentiated thyroid cancer. (medscape.com)
  • anxiety , and fatigue patient after total thyroidectomy with thyroid cancer are considered for participation. (bioportfolio.com)
  • The fact that definite characterization of follicular neoplasms is predominantly a postoperative histological diagnosis (core criteria: capsular, vascular and adjacent tissue invasion) translates into the challenge for the thyroid surgeon to plan preoperatively for presence of malignancy and, if required, to adapt the surgical strategy according to intraoperative (frozen section) or postoperative histological findings. (unboundmedicine.com)
  • Of the 365 cases with a malignant diagnosis by FNA over a period of 11 years, nine (2.4 %) were identified with discrepant histologic diagnosis with regard to the type of primary thyroid malignancy. (cytojournal.com)
  • A small subset of primary malignant neoplasms of the thyroid may be misclassified with regard to the type of malignancy on FNA. (cytojournal.com)
  • The management of thyroid cancer is strongly influenced by the FNA diagnosis and since clinical treatment algorithms vary depending upon the specific subtype of thyroid cancer, especially with regard to surgical intervention, an accurate subclassification of the malignancy is important. (cytojournal.com)
  • A Proposal for Separation of Nuclear Atypia and Architectural Atypia in Bethesda Category III (AUS/FLUS) Based on Differing Rates of Thyroid Malignancy. (uchicago.edu)
  • Sub categorization of Thy 3 into a and b increases the specificity of FNAC in detecting thyroid malignancy. (sljol.info)
  • Preoperative [ 18 F]-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging may be able to determine malignancy in follicular neoplasms. (nebraska.edu)
  • Conclusion: Despite certain patterns being suggestive of malignancy, FDG-PET can not consistently predict the malignant potential of a follicular neoplasm. (nebraska.edu)
  • Preoperative [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging may be able to determine malignancy in follicular neoplasms. (nebraska.edu)
  • These results clearly confirmed that the risk stratification of follicular neoplasms, which was adapted from cytology practice of high-volume thyroid centers in Japan, can provide clinically helpful information to estimate the risk of malignancy and to triage patients for surgery. (elsevier.com)
  • The independent predictors of malignancy in follicular or Hürthle cell neoplasms are sex and preoperative Tg concentration. (biomedcentral.com)
  • These cases were classified as benign lesion (BL, eight cases), FN, including the ACUS category of the Bethesda classification (FN/AUS, 50 cases), suspicious for malignancy (SM, 59 cases), and malignant neoplasm (MN, three cases). (unicatt.it)
  • Rosário, Pedro 2017-11-10 00:00:00 World J Surg (2018) 42:2277-2278 DOI 10.1007/s00268-017-4351-6 LETTE R T O T HE EDI T OR Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Did We Trade Six for a Half a Dozen? (deepdyve.com)
  • Thyroid cancers are mainly papillary, follicular, medullary or anaplastic thyroid cancer. (wikipedia.org)
  • Thyroid lobectomy is not sufficient for T2 papillary thyroid cancers. (springermedizin.de)
  • The authors certainly support the de-escalation of treatment of these low-risk thyroid cancers including the use of thyroid lobectomy and more selective radioactive iodine ablation. (paperity.org)
  • Much progress has been made toward avoiding overdiagnosis and overtreatment of thyroid cancers. (e-enm.org)
  • The follicular thyroid cancers that exhibited only capsular invasion had an average SUV of 3.1, whereas those with vascular invasion had an average SUV of 39.9. (nebraska.edu)
  • Assessing nuclear features is diagnostically challenging in the aspect of thyroid pathology. (e-enm.org)
  • Materials and methods: The archives of 8 participating institutions were searched for thyroid resection specimens obtained in a 1-year period, and pertinent demographic and pathology data were recorded. (elsevier.com)
  • The surgical dilemma of primary surgery for follicular thyroid neoplasms. (unboundmedicine.com)
  • TY - JOUR T1 - The surgical dilemma of primary surgery for follicular thyroid neoplasms. (unboundmedicine.com)
  • citation needed] Radioactive iodine-131 is used in patients with papillary or follicular thyroid cancer for ablation of residual thyroid tissue after surgery and for the treatment of thyroid cancer. (wikipedia.org)
  • Is a Thyroid Follicular Neoplasm a Good Indication for Endoscopic Surgery? (ovid.com)
  • Surgery of the Thyroid and Parathyroid Glands. (medlineplus.gov)
  • Thyroid and parathyroid surgery in pregnancy. (medscape.com)
  • Outcomes following thyroid and parathyroid surgery in pregnant women. (medscape.com)
  • As thyroid cancer rates rise, more people are having surgery to remove all or part of their thyroid. (medicalxpress.com)
  • A cytologic diagnosis of follicular neoplasm with atypical cells of undetermined significance (FN/AUS) implies that the selection of patients between surgery and follow-up is difficult. (unicatt.it)
  • METHODS: Out of 7091 thyroid FNAB processed by LBC method, 120 cases undergoing surgery successively were selected. (unicatt.it)
  • What are the ATA guidelines on preoperative imaging for thyroid cancer surgery? (medscape.com)
  • American thyroid association statement on preoperative imaging for thyroid cancer surgery. (medscape.com)
  • Patients' knowledge about the outcomes of thyroid biopsy: a patient survey. (uams.edu)
  • Doctors use a physical exam, thyroid tests, other blood and imaging tests, and a biopsy to diagnose thyroid cancer. (icdlist.com)
  • Needle core biopsy appears to have a low rate of associated complications, and its sensitivity for diagnosing PC and follicular neoplasm is comparable to what has been reported for fine needle aspiration biopsy in a similar patient population. (nih.gov)
  • As the biopsy needle passes into your thyroid, you may feel some pressure, but it should not be painful. (medlineplus.gov)
  • Cytologic examination of a fine-needle aspiration biopsy specimen cannot distinguish between benign and malignant follicular or Hürthle cell neoplasms. (biomedcentral.com)
  • Gharib H, Goellner JR. Fine-needle aspiration biopsy of the thyroid: an appraisal. (medscape.com)
  • In CCRCC patients, a particularly prolonged survival rate may be achieved with the appropriate therapy, in contrast to the ominous prognosis typically found in patients with thyroid metastases from other origins. (hindawi.com)
  • This phase II trial is studying how well tanespimycin works in treating patients with inoperable locoregionally advanced or metastatic thyroid cancer. (clinicaltrials.gov)
  • I. Determine the objective response rate in patients with metastatic and/or locally advanced or locally recurrent thyroid cancer treated with suberoylanilide hydroxamic acid. (clinicaltrials.gov)
  • miRNA expression can classify pediatric thyroid lesions and increases the diagnostic yield of mutation testing. (uams.edu)
  • We report our experience on the management of Hurthle cell neoplasms (HCNs) of the thyroid and a review of the literature in order to describe the most relevant clinical, diagnostic, biologic and therapeutic aspects. (mattioli1885journals.com)
  • Currently In the Market There is No Accepted Test That Will Improve Our Pre-operative Diagnostic Accuracy Of Follicular Neoplasms. (corfo.cl)
  • However, our previous studies in patients with large follicular or Hürthle cell neoplasms (median size 3 cm) showed that measurement of the preoperative serum Tg concentration may represent a useful preoperative diagnostic test. (biomedcentral.com)
  • Utility of galectin 3 expression in thyroid aspirates as a diagnostic marker in differentiating benign from malignant thyroid neoplasms. (bvsalud.org)
  • Which of the following is not a histological variant of thyroid neoplasm? (pgblazer.com)
  • Histological typing of thyroid tumours / Chr. (who.int)
  • In the ICD-O codes, the morphology code records the histological type of the neoplasm and its biological activity in terms of how it behaves. (e-enm.org)
  • Metade da casuística foi classificada como baixo risco, segundo a estratificação de risco da American Thyroid Association (ATA). (usp.br)
  • Fine needle aspiration (FNA) cytology is a popular, reliable and cost effective technique for the diagnosis of thyroid lesions. (cytojournal.com)
  • To determine the validity of Fine needle aspiration cytology (FNAC) in diagnosing thyroid neoplasms and to identify the causes of false positive and negative results. (sljol.info)
  • This study examined observer variability in the subclassification of follicular neoplasms among 4 reviewers using Papanicolaou-stained smear samples from 20 surgically treated patients with indeterminate cytology. (elsevier.com)
  • Factors related with metastasis of right retroesophageal lymph nodes in papillary thyroid cancer. (medscape.com)
  • Ultrasound features of thyroid lesions. (helsinki.fi)
  • We analysed the expression profile of PLZF in different types of benign and malignant thyroid lesions as well as in normal thyroid tissue. (biomedcentral.com)
  • PLZF was expressed in all samples of thyroid lesions examined. (biomedcentral.com)
  • PLZF shows different subcellular localizations among PTC, ATC, and other thyroid lesions. (biomedcentral.com)
  • In the present study, we analysed the expression and intracellular distribution of PLZF in different types of benign and malignant thyroid lesions. (biomedcentral.com)
  • The differential diagnosis of neuroendocrine neoplasms of the larynx is broad and includes lesions of epithelial, mesenchymal, and neuroectodermal origin. (nih.gov)
  • These lesions have overlapping clinical and pathologic aspects and must be carefully considered in the differential diagnosis of laryngeal neoplasms. (nih.gov)
  • Overdiagnosis and overtreatment of thyroid cancer: A population-based temporal trend study. (bioportfolio.com)
  • The classification is determined by looking at the sample of cells under a microscope and determining the type of thyroid cell that is present. (wikipedia.org)
  • These findings suggest an important role for the immunoperoxidase technique in the precise classification of anaplastic small cell neoplasms of the thyroid. (utmb.edu)
  • Advances in medical sciences and evidence-based medicine have led to momentous changes in classification and management of thyroid neoplasms. (e-enm.org)
  • The first step in diagnosing a thyroid neoplasm is a physical exam of the neck area. (wikipedia.org)
  • The authors report a case of primary thyroid osteosarcoma in a male patient presenting a tumoral mass in the neck. (ufrgs.br)
  • The hyoid bone, thyroid cartilage, and cricoid cartilages are located within the central portion of the neck. (aafp.org)
  • Nontoxic diffuse goiter, nodular thyroid disorders, and thyroid malignancies. (medlineplus.gov)
  • It was found that aside from the above conditions, mature adipose tissue has been reported in diffuse lipomatosis of the thyroid, some amyloid goiters, a colloid goiter, and even some normal thyroids. (houstonmethodist.org)
  • Contrast material iodides: potential effects on radioactive iodine thyroid uptake. (medscape.com)
  • The investigators want to find out if AZD6244 helps to increase the entry of radioactive iodine into thyroid cancer cells that have spread and are resistant to radioactive iodine therapy, especially if they have the BRAF mutation. (bioportfolio.com)
  • This phase II trial is studying how well AZD6244 works in treating patients with papillary thyroid cancer that did not respond to radioactive iodine. (bioportfolio.com)
  • Has anyone had a follicular neoplasm which turned out to be cancer of the thyroid? (medhelp.org)
  • Here we investigated the computed tomography (CT) features of follicular neoplasms, toward the goal of being able to identify specific CT features allowing the preoperative differentiation of FTC from FTA. (okayama-u.ac.jp)
  • The aim of this study was to find out whether preoperative serum Tg concentration is a predictive factor of malignant disease in patients with a follicular or Hürthle cell neoplasm with a diameter of 2 cm or less. (biomedcentral.com)
  • International neuromonitoring study group guidelines 2018: Part II: Optimal recurrent laryngeal nerve management for invasive thyroid cancer-incorporation of surgical, laryngeal, and neural electrophysiologic data. (uchicago.edu)
  • Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Did We Trade Six for a Half a Dozen? (deepdyve.com)
  • All potential NIFTP cases were reviewed by a thyroid pathologist. (sparrho.com)
  • hence, a change in terminology to "noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)" has been proposed. (elsevier.com)
  • The point mutation in Ras genes (H-Ras, K-Ras, and N-Ras) has been highlighted in thyroid neoplasia with an overall different incidence according to the histotype. (omicsonline.org)
  • In the United States, thyroid cancer incidence is rising among young people as well as Hispanics and African Americans, a new study reports. (medicalxpress.com)
  • Morris LG, Sikora AG, Tosteson TD, Davies L. The increasing incidence of thyroid cancer: the influence of access to care. (medscape.com)
  • The increase in incidence of thyroid cancer during the last decades without concomitant rise in mortality may reflect the growing detection of indolent forms of thyroid cancer, and may have fueled unn. (bioportfolio.com)
  • In addition, increased systemic inflammatory reaction can be poor prognostic factor in thyroid cancer. (intechopen.com)
  • However, other studies are needed to validate molecular alterations as an independent prognostic factor in thyroid cancer. (scielo.br)
  • This study was designed to campare the expressions of TTF-1 and Ki-67 on non- neoplastic and neoplastic thyroid tissues . (bvsalud.org)