Tumors or cancer of the THYMUS GLAND.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Enlargement of the thymus. A condition described in the late 1940's and 1950's as pathological thymic hypertrophy was status thymolymphaticus and was treated with radiotherapy. Unnecessary removal of the thymus was also practiced. It later became apparent that the thymus undergoes normal physiological hypertrophy, reaching a maximum at puberty and involuting thereafter. The concept of status thymolymphaticus has been abandoned. Thymus hyperplasia is present in two thirds of all patients with myasthenia gravis. (From Segen, Dictionary of Modern Medicine, 1992; Cecil Textbook of Medicine, 19th ed, p1486)
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A plant genus of the family LAMIACEAE best known for the thyme spice added to foods.
Neoplasms containing cyst-like formations or producing mucin or serum.
Extracts of the thymus that contain specific, but uncharacterized factors or proteins with specific activities; three distinct substances are already known: thymotoxin, thymin and thymosin.
Humoral factors secreted by the thymus gland. They participate in the development of the lymphoid system and the maturation of the cellular immune response.
Tumors or cancer of the SKIN.
Surgical removal of the thymus gland. (Dorland, 28th ed)
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Tumors or cancers of the KIDNEY.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
An encapsulated lymphatic organ through which venous blood filters.
Tumors or cancer of the THYROID GLAND.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
DNA present in neoplastic tissue.
Tumors or cancer of the LUNG.
Tumors or cancer of the PAROTID GLAND.
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
Tumors or cancer of the LIVER.
Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.
Tumors or cancer of the APPENDIX.
A general term for various neoplastic diseases of the lymphoid tissue.
A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Tumors or cancer of the ENDOCRINE GLANDS.
A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.
Tumors or cancer of the EYE.
Tumors or cancer of the NOSE.
Tumors or cancer of the SALIVARY GLANDS.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.
HEMATOPOIETIC PROGENITOR CELLS that have migrated to the THYMUS where they differentiate into T-LYMPHOCYTES. Thymocytes are classified into maturational stages based on the expression of CELL SURFACE ANTIGENS.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
A benign epithelial tumor with a glandular organization.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Tumors or cancer of the UTERUS.
Tumors or cancer of the INTESTINES.
Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Tumors or cancer located in bone tissue or specific BONES.
Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.
Neoplasms composed of more than one type of neoplastic tissue.
Tumors or cancer of the MANDIBLE.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Tumors or cancer of the BILE DUCTS.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the SPLEEN.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Tumors or cancer of the COLON.
Cancer or tumors of the MAXILLA or upper jaw.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.
Tumors or cancer of the anal gland.
Tumors or cancer of the MEDIASTINUM.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Tumors or cancer of the DUODENUM.
A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Tumors or cancers of the ADRENAL CORTEX.
Tumors or cancer of the MOUTH.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Tumors or cancer of the TONGUE.
Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.
Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).
Tumors or cancer of the STOMACH.
Experimentally induced tumors of the LIVER.
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
Tumors or cancer of the URINARY BLADDER.
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Tumors or cancer of the VAGINA.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
A malignant epithelial tumor with a glandular organization.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.
A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE DISORDERS.
Surgical removal of the pancreas. (Dorland, 28th ed)
Formation of LYMPHOCYTES and PLASMA CELLS from the lymphoid stem cells which develop from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW. These lymphoid stem cells differentiate into T-LYMPHOCYTES; B-LYMPHOCYTES; PLASMA CELLS; or NK-cells (KILLER CELLS, NATURAL) depending on the organ or tissues (LYMPHOID TISSUE) to which they migrate.
Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)
A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.

Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor beta receptor therapy. (1/1008)

Many types of tumor cells overexpress transforming growth factor beta (TGF-beta), which is believed to promote tumor progression. We hypothesized that overexpression of the extracellular region of the type II TGF-beta receptor (soluble TbetaRII) would compete for or block TGF-beta binding to TbetaRs on immune cells, preventing TGF-beta-mediated immunosuppression and consequently resulting in the eradication of tumor cells. We tested this in the mouse thymoma cell line EL4, which has been reported to suppress cellular immunity by secreting a large amount of TGF-beta. Transduction of EL4 with recombinant retrovirus encoding soluble TbetaRII resulted in the secretion of heterogeneously glycosylated, 25 to 35 kDa truncated TbetaRII. Inoculation of 1 x 10(4) to 5 x 10(4) soluble TbetaRII-modified EL4 cells (EL4/Ts, EL4 cells transduced with recombinant retrovirus encoding soluble TbetaRII and neomycin resistance gene) s.c. to mice showed reduced tumorigenicity, as indicated by lower overall tumor incidence (7%, 1 of 14; P < 0.001) compared with unmodified EL4 (100%, 9 of 9) or vector-modified EL4 cells (EL4/neo, EL4 cells transduced with recombinant retrovirus encoding neomycin resistance gene; 100%, 4 of 4). Administration of mitomycin C-treated EL4/Ts cells (1 x 10(6)) after EL4 inoculation (1 x 10(4)) reduced tumor incidence from 100% (5 of 5 in mice inoculated with mitomycin C-treated EL4/neo) to 40% (4 of 10, P < 0.05), indicating that supply of soluble TbetaRII could actually block TGF-beta-mediated tumorigenesis. In vitro tumor cytotoxicity assays revealed 3-5-fold higher cytotoxic activity with lymphocytes from EL4/Ts-bearing mice compared with those from EL4- or EL4/neo-bearing mice, indicating that the observed tumor rejection was mediated by restoration of the tumor-specific cellular immunity. These data suggest that expression of soluble TbetaRII is an effective strategy for treating highly progressive tumors secreting TGF-beta.  (+info)

Invasive thymoma with long-term survival by extensive reoperation. (2/1008)

The recurrence of invasive thymoma is often observed; however, no accepted treatment of recurrent invasive thymoma has yet been established. We herein report a 41-year-old woman with invasive thymoma and pleural dissemination who demonstrated long-term survival after undergoing 4 operations. Based on our findings, reoperation is thus suggested in patients with intrathoracic recurrence and long-term survival can be expected.  (+info)

Primary mediastinal malignancies: findings in 219 patients. (3/1008)

The purpose of this study was to determine the demographics, histology, methods of treatment, and survival in primary mediastinal malignancies. We did a retrospective review of the statewide New Mexico Tumor Registry for all malignant tumors treated between January 1, 1973 and December 31, 1995. Benign tumors and cysts of the mediastinum were excluded. Two hundred nineteen patients were identified from a total of 110,284 patients with primary malignancies: 55% of tumors were lymphomas, 16% malignant germ cell tumors, 14% malignant thymomas, 5% sarcomas, 3% malignant neurogenic tumors, and 7% other tumors. There were significant differences in gender between histologies (P < 0.001). Ninety-four percent of germ cell tumors occurred in males, 66% of neurogenic tumors were in females; other tumors occurred in males in 58% of cases. There were also significant differences in ages by histology (P < 0.001). Neurogenic tumors were most common in the first decade, lymphomas and germ cell tumors in the second to fourth decades, and lymphomas and thymomas in patients in their fifth decades and beyond. Stage at presentation (P = 0.001) and treatment (P < 0.001) also differed significantly between histologic groups. Five-year survival was 54% for lymphomas, 51% for malignant germ cell tumors, 49% for malignant thymomas, 33% for sarcomas, 56% for neurogenic tumors, and 51% overall. These survival rates were not statistically different (P > 0.50). Lymphomas, malignant germ cell tumors, and thymomas were the most frequently encountered malignant primary mediastinal neoplasms in this contemporary series of patients. Demographics, stage at presentation, and treatment modality varied significantly by histology. Despite these differences, overall five-year survival was not statistically different.  (+info)

Promoter element for transcription of unrearranged T-cell receptor beta-chain gene in pro-T cells. (4/1008)

The hallmark of T- and B-lymphocyte development is the rearrangement of variable (V), diversity (D), and joining (J) segments of T-cell receptor (TCR) and immunoglobulin (Ig) genes to generate a diverse repertoire of antigen receptor specificities in the immune system. The process of V(D)J recombination is shared in the rearrangement of all seven antigen receptor genes and is controlled by changes in chromatin structure, which regulate accessibility to the recombinase apparatus in a lineage- and stage-specific manner. These chromatin changes are linked to transcription of the locus in its unrearranged (germline) configuration. To understand how germline transcription of the TCRbeta-chain gene is regulated, we determined the structure of germline transcripts initiating near the Dbeta1 segment and identified a promoter within this region. The Dbeta1 promoter is active in the presence of the TCRbeta enhancer (Ebeta), and in this context, exhibits preferential activity in pro-T versus mature T-cell lines, as well as T- versus B-lineage specificity. These studies provide insight into the developmental regulation of TCRbeta germline transcription, one of the earliest steps in T-cell differentiation.  (+info)

Gastroenteropancreatic neuroendocrine tumor metastases to the thyroid gland: differential diagnosis with medullary thyroid carcinoma. (5/1008)

Neuroendocrine tumors (NET) of the thyroid gland are rare. Apart from medullary thyroid carcinoma (MTC), metastases of gastroenteropancreatic (GEP) NET may also occur. Features of six patients (five men, one female: age range, 39-67 years) with thyroid metastases from a GEP-NET are described. Thyroid metastases were bilateral in all patients and were associated with enlarged neck lymph nodes in five. In four cases, the thyroid tumor was either the first sign of the disease (n = 2) or was an isolated site of recurrence (n = 2). The tumors were well (n = 3) or poorly differentiated (n = 3). Five tumors for which the primary site could be determined corresponded to foregut-derived tumors (3 lungs, 1 thymus and 1 pancreatic NET). One tumor demonstrated calcitonin (CT) production as shown by immunohistochemistry and elevated plasma CT levels. However, the disease history and the clinical features strongly favored a metastasizing GEP-NET. No tumoral RET proto-oncogene mutation was found in this patient. The differential diagnosis between metastatic GEP-NET and MTC is crucial because prognosis, work-up, and treatment differ greatly.  (+info)

Dermatomyositis associated with invasive thymoma. (6/1008)

We report a case of dermatomyositis (DM) associated with invasive thymoma in a 22-year-old woman who was admitted to our hospital complaining of dyspnea which required ventilation support. The reddened elevated scaly eruptions were prominent over the extensor surfaces. Chest X-ray and computed tomography showed mediastinal masses, which were diagnosed as mixed type thymoma. Muscle and skin biopsy specimens were compatible with DM. She was treated with methylprednisolone pulse therapy followed by extended removal of the anterior mediastinal tumor and subsequent radiotherapy. She has had a good clinical course without recurrence of thymoma or DM for more than 3 years. The role of thymoma in the development of DM is discussed.  (+info)

Novel endogenous type D retroviral particles expressed at high levels in a SCID mouse thymic lymphoma. (7/1008)

A xenograft model of the human disease Langerhans cell histiocytosis (LCH) was investigated with severe combined immunodeficiency (SCID) mice. Transplantation of human LCH biopsy material into SCID mice resulted in the generation of mouse tumors resembling lymphomas. A thymoma cell line (ThyE1M6) was generated from one of these mice and found to display significant levels of Mg2+-dependent reverse transcriptase activity. Electron microscopy revealed particles with type D retroviral morphology budding from ThyE1M6 cells at a high frequency, whereas control cultures were negative. Reverse transcription-PCR of virion RNA with degenerate primers for conserved regions of various mouse, human, and primate retroviruses amplified novel sequences related to primate type D retroviruses, murine intracisternal A particles, Jaagsiekte sheep retrovirus, and murine long interspersed nuclear elements but not other retroviral classes. We demonstrate that these sequences represent a novel group of endogenous retroviruses expressed at low levels in mice but expressed at high levels in the ThyE1M6 cell line. Furthermore, we propose that the activation of endogenous retroviral elements may be associated with a high incidence of thymomas in SCID mice.  (+info)

Sequences between the enhancer and promoter in the long terminal repeat affect murine leukemia virus pathogenicity and replication in the thymus. (8/1008)

We previously showed that the 93-bp region between the enhancer and promoter (named DEN for downstream of enhancer) of the long terminal repeat (LTR) of the MCF13 murine leukemia virus is an important determinant of the ability of this virus to induce thymic lymphoma. In this study we observed that DEN plays a role in the regulation of virus replication in the thymus during the preleukemic period. A NF-kappaB site in the DEN region partially contributes to the effect of DEN on both lymphomagenicity and virus replication. To further study the effects of DEN and the NF-kappaB site on viral pathogenicity during the preleukemic period, we examined replication of wild-type and mutant viruses with a deletion of the NF-kappaB site or the entire DEN region in the thymus. Thymic lymphocytes which were infected with wild-type and mutant viruses were predominantly the CD3(-) CD4(+) CD8(+) and CD3(+) CD4(+) CD8(+) cells. The increase in infection by wild-type virus and both mutant viruses of these two subpopulations during the preleukemic period ranged from 9- to 84-fold, depending upon the time point and virus. The major difference between the wild-type and both mutant viruses was the lower rate and lower level of mutant virus replication in these thymic subpopulations. Significant differences in replication between wild-type and both mutant viruses were seen in the CD3(-) CD4(+) CD8(+) and CD3(-) CD4(-) CD8(-) subpopulations, suggesting that these thymic cell types are important targets for viral transformation.  (+info)

TY - JOUR. T1 - The ITMIG/IASLC thymic epithelial tumors staging project. T2 - A proposed lymph node map for thymic epithelial tumors in the forthcoming 8th edition of the TNM classification of malignant tumors. AU - Bhora, Faiz Y.. AU - Chen, David J.. AU - Detterbeck, Frank C.. AU - Asamura, Hisao. AU - Falkson, Conrad. AU - Filosso, Pier Luigi. AU - Giaccone, Giuseppe. AU - Huang, James. AU - Kim, Jhingook. AU - Kondo, Kazuya. AU - Lucchi, Marco. AU - Marino, Mirella. AU - Marom, Edith M.. AU - Nicholson, Andrew G.. AU - Okumura, Meinoshin. AU - Ruffini, Enrico. AU - Van Schil, Paul. AU - Goldstraw, Peter. AU - Rami-Porta, Ramón. AU - Ball, David. AU - Beer, David. AU - Beyruti, Ricardo. AU - Bolejack, Vanessa. AU - Chansky, Kari. AU - Crowley, John. AU - Eberhardt, Wilfried Ernst Erich. AU - Edwards, John. AU - Galateau-Sallé, Françoise. AU - Giroux, Dorothy. AU - Gleeson, Fergus. AU - Groome, Patti. AU - Kennedy, Catherine. AU - Kim, Young Tae. AU - Kingsbury, Laura. AU - Kondo, ...
TY - JOUR. T1 - Apoptosis in thymic epithelial tumors. AU - Park, Sung Hye. AU - Kim, Han Kyeom. AU - Kim, Hanseong. AU - Ro, Jae Y.. PY - 2002/1/1. Y1 - 2002/1/1. N2 - We studied Fas/FasL, Bcl-2, and M30 CytoDeath in five cases of normal thymus and 41 cases of thymic epithelial tumors (TETs). In normal thymus, Fas was expressed in all epithelial cells, but not in thymic lymphocytes; FasL was weakly expressed only in medullary epithelium and Hassals corpuscles. In TETs, Fas was expressed in all epithelial cells and lymphocytes, while FasL was differently expressed in epithelial cells of different subtypes of TETs, i.e., type A (2/2), AB (12/12), B1 (0/9), B1/B2 (0/3), B2 (0/1), B2/B3 (1/3), B3 (6/10) and C (1/1), but not in lymphocytes. Bcl2 protein was strongly expressed in medullary-derived lymphocytes of normal thymus and TETs, and weakly expressed only in medullary (spindle) epithelium of TETs. On M30 CytoDeath immunostaining, apoptotic indices were very low in all TETs (0-1.2). In ...
TY - JOUR. T1 - Prognosis of surgically treated thymic epithelial tumors. AU - Horinouchi, Hirohisa. AU - Asakura, Keisuke. AU - Kimura, Yoshishige. AU - Takeuchi, Ken. AU - Kawamura, Masafumi. AU - Watanabe, Masazumi. AU - Eguchi, Keisuke. AU - Kobayashi, Koichi. PY - 2006/11. Y1 - 2006/11. N2 - This study was performed to clarify the prognosis of patients with surgically treated thymic epithelial tumors. The records of 131 patients who underwent surgical treatment during 1985-2005 were retrospectively reviewed. Pathologic review was done according to the WHO classification of tumors of the thymus. Patients characteristics were: 76 male and 55 fimale; average age 53 (range 20-80) years; tumor stage was stage I in 42, stage II in 43, stage III in 23, stage IVa in 15, stage IVb in 1, and thymic carcinoma (squamous cell carcinoma) in 7 based on Masaokas staging. There were 7 cases of type A, 23 of type AB, 30 of type B1, 27 of type B2, 29 of type B3, and 15 of type C. Surgical procedures ...
To gain further insight into the biology of thymic tumors, we did a comprehensive molecular analysis of 45 resected thymic tumors. To our knowledge, this study represents one of the first and largest of its kind. Previous studies have focused on only a small number of tumors (29) and used only a limited number of analytic methods (29-31). Our analysis has three main new findings.. First, mutational analysis of genes encoding components of the EGFR signaling pathway led to the identification of RAS mutations in 3 (7%) of 45 thymic epithelial tumors. Previously, investigators have collectively assessed the status of only one RAS gene (i.e., KRAS) in 17 tumors (16, 32, 33) but did not identify any mutation. In our study, two RAS mutant tumors were thymomas (type A and B2) that are low grade, and the other tumor was a thymic carcinoma that is high grade. KRAS mutations predict for primary resistance to anti-EGFR directed therapies [i.e., gefitinib/erlotinib in lung cancer (34) and cetuximab in colon ...
TY - JOUR. T1 - Reproducibility of 3 histologic classifications and 3 staging systems for thymic epithelial neoplasms and its effect on prognosis. AU - Roden, Anja. AU - Yi, Eunhee S.. AU - Jenkins, Sarah M.. AU - Edwards, Kelly K.. AU - Donovan, Janis L.. AU - Lewis, Jean E.. AU - Cassivi, Stephen D.. AU - Marks, Randolph Stuart. AU - Garces, Yolanda Isabel. AU - Aubry, Marie Christine. PY - 2015/3/30. Y1 - 2015/3/30. N2 - Data regarding the prognostic significance of the histopathologic classifications of thymic epithelial neoplasms are contradictory, perhaps reflecting issues in reproducibility. We studied the effect of reproducibility of 3 histopathologic classifications on prognosis and investigated the interobserver agreement on invasion and its effect on staging and prognosis. A total of 456 patients who underwent surgery for thymic epithelial neoplasm at Mayo Clinic Rochester (1942 to 2008) were staged (modified Masaoka, proposed Moran, proposed IASLC/ITMIG) and independently classified ...
TY - JOUR. T1 - Epidermal growth factor receptor, c-kit, and her2/neu immunostaining in advanced or recurrent thymic epithelial neoplasms staged according to the 2004 world health organization in patients treated with octreotide and prednisone. T2 - an eastern cooperative oncology group study. AU - Aisner, Seena C.. AU - Dahlberg, Suzanne. AU - Hameed, Meera R.. AU - Ettinger, David S.. AU - Schiller, Joan H.. AU - Johnson, David H.. AU - Aisner, Joseph. AU - Loehrer, Patrick J.. PY - 2010/6. Y1 - 2010/6. N2 - BACKGROUND:: Advanced or recurrent nonresectable thymic epithelial tumors show only a modest response to standard chemotherapy. A recent study using octreotide and prednisone in thymic tumors, Eastern Cooperative Oncology Group study E1C97, was conducted to verify the activity of octreotide for thymic tumors. The aim of this study was to determine whether epidermal growth factor receptor (EGFR) immunoreactivity correlated with outcomes and to identify new biologic markers for potential ...
TY - JOUR. T1 - Thymic tumor with adenoid cystic carcinomalike features. T2 - A clinicopathologic study of 4 cases. AU - Di Tommaso, Luca. AU - Kuhn, Elisabetta. AU - Kurrer, Michael. AU - Zettl, Andreas. AU - Marx, Alex. AU - Müller-Hermelink, Hans Konrad. AU - Roncalli, Massimo. AU - Rosai, Juan. PY - 2007/8. Y1 - 2007/8. N2 - Thymic carcinomas are rare malignant neoplasms which comprise several histologic subtypes. Adenoid cystic carcinoma (ACC) is included among these subtypes even if it has never been formally reported. We evaluated the clinical, radiologic, morphologic, immunohistochemical, and genetic features of 4 cases of thymic neoplasms with ACC-like features retrieved from the authors consult files. Most cases affected adult/elderly males (mean 68.5 y; range: 63 to 77 y; M:F ratio=3:1), and were asymptomatic. The clinical history (no evidence of ACC in other sites), radiologic findings (a mass in the thymic region), and morphologic features (residual thymic tissue at the periphery ...
title: Early Masaoka stage and complete resection is important for prognosis of thymic carcinoma: a 20-year experience at a single institution., doi: 10.1016/j.ejcts.2009.02.019, category: Article
Overview Masses in the anterior mediastinum include neoplasms (e.g., thymomas, lymphomas, thymic carcinomas, thymic carcinoids, thymolipomas, germ cell tumors, parathyroid adenomas) or nonneoplastic conditions (e.g., intrathoracic goiter, thymic cysts, lymphangiomas, aortic aneurysms).1,2 Thymomas are the most common tumor in the anterior mediastinum.1,3,4 Many mediastinal masses are benign, especially those occurring in asymptomatic patients; however, symptomatic patients often have malignant mediastinal lesions. These guidelines outline the evaluation, treatment, and management of thymomas and thymic carcinomas (see Thymic Masses, opposite column). The WHO histologic classification system can be used to distinguish among thymomas, thymic carcinomas, and thymic carcinoids.3 Lymphomas typically manifest as generalized disease but can also be primary anterior mediastinal lesions (i.e., nodular sclerosing Hodgkin disease and non-Hodgkins lymphomas [large B-cell lymphoma and lymphoblastic ...
Overview Masses in the anterior mediastinum include neoplasms (e.g., thymomas, lymphomas, thymic carcinomas, thymic carcinoids, thymolipomas, germ cell tumors, parathyroid adenomas) or nonneoplastic conditions (e.g., intrathoracic goiter, thymic cysts, lymphangiomas, aortic aneurysms).1,2 Thymomas are the most common tumor in the anterior mediastinum.1,3,4 Many mediastinal masses are benign, especially those occurring in asymptomatic patients; however, symptomatic patients often have malignant mediastinal lesions. These guidelines outline the evaluation, treatment, and management of thymomas and thymic carcinomas (see Thymic Masses, opposite column). The WHO histologic classification system can be used to distinguish among thymomas, thymic carcinomas, and thymic carcinoids.3 Lymphomas typically manifest as generalized disease but can also be primary anterior mediastinal lesions (i.e., nodular sclerosing Hodgkin disease and non-Hodgkins lymphomas [large B-cell lymphoma and lymphoblastic ...
Recent work with immunotherapy has shown promising results with treatment of several solid malignancies, and there are several reports of good systemic responses with the combination of immunotherapy and radiation therapy (RT), most notably in advanced melanoma. Given the rapid increase in the use of checkpoint blockade as well as anti-tumor vaccines, we review here the preclinical rationale and ongoing clinical work in combining immunotherapy with RT for small cell lung cancer (SCLC) and thymic tumors. While there are several reports of promising results with the combination of immunotherapy and conventional systemic treatment, we focus here on the ongoing clinical studies that combine immunotherapy with RT, and highlight the emerging data for this multimodality approach as well as key preclinical and clinical issues that remain to be addressed. With regards to SCLC, trials exploring to the combination of immunotherapy and RT are already ongoing, but clinical studies for this combination in thymoma are
TY - JOUR. T1 - The Integrated Genomic Landscape of Thymic Epithelial Tumors. AU - The Cancer Genome Atlas Network. AU - Radovich, Milan. AU - Pickering, Curtis R.. AU - Felau, Ina. AU - Ha, Gavin. AU - Zhang, Hailei. AU - Jo, Heejoon. AU - Hoadley, Katherine A.. AU - Anur, Pavana. AU - Zhang, Jiexin. AU - McLellan, Mike. AU - Bowlby, Reanne. AU - Matthew, Thomas. AU - Danilova, Ludmila. AU - Hegde, Apurva M.. AU - Kim, Jaegil. AU - Leiserson, Mark D.M.. AU - Sethi, Geetika. AU - Lu, Charles. AU - Ryan, Michael. AU - Su, Xiaoping. AU - Cherniack, Andrew D.. AU - Robertson, Gordon. AU - Akbani, Rehan. AU - Spellman, Paul. AU - Weinstein, John N.. AU - Hayes, D. Neil. AU - Raphael, Ben. AU - Lichtenberg, Tara. AU - Leraas, Kristen. AU - Zenklusen, Jean Claude. AU - Ally, Adrian. AU - Appelbaum, Elizabeth L.. AU - Auman, J. Todd. AU - Balasundaram, Miruna. AU - Balu, Saianand. AU - Behera, Madhusmita. AU - Beroukhim, Rameen. AU - Berrios, Mario. AU - Blandino, Giovanni. AU - Bodenheimer, Tom. AU - ...
Chemotherapy is the definitive treatment for inoperable or recurrent thymoma and thymic carcinoma. It can also be used to decrease the size of potentially operable tumors in order to increase the chances of successful surgery. Several chemotherapy drugs are active against thymic cancers. These include cisplatin, carboplatin, doxorubicin, cyclophosphamide, paclitaxel, etoposide, pemetrexed, gemcitabine, capecitabine and ifosfamide. In general, a combination of chemotherapy drugs is used for treatment of newly diagnosed inoperable thymic cancers or for pre-surgical treatment of locally advanced disease. Recurrent thymic cancers are usually treated with a single drug, although combination chemotherapy can also be considered in select cases. Commonly used combinations for treatment of newly diagnosed advanced thymoma or thymic carcinoma include cisplatin with doxorubicin and cyclophosphamide (commonly referred to as the PAC or CAP regimen), cisplatin with etoposide, or carboplatin with paclitaxel. ...
Background: Thymomas and thymic carcinomas are rare malignancies and devising clinically effectivemolecular targeted therapies is a major clinical challenge. The aim of the study was to analyze BLC2 andvascular endothelial growth factor receptor (VEGFR) expression and KRAS and EGFR mutational status andto correlate them with the clinical characteristics of patients with thymomas and thymic carcinomas. Materialsand Methods: A total of 62 patients (mean age: 50.4±13.2 years) with thymomas and thymic carcinomas wereenrolled. The expression of BLC2 and VEGFR in tumor cells and normal tissues was evaluated by RT-PCR.The mutational status of the KRAS and EGFR genes was investigated by PCR with sequence specific primers.Results: The BLC2 and VEGFR expression levels did not differ significantly between tumor and normal tissues.Moreover, there were no clearly pathogenic mutations in KRAS or EGFR genes in any tumor. None of themolecular markers were significantly related to clinical outcomes. Conclusions:
Clinical trial for Recurrent Thymic Carcinoma | Locally Advanced Thymic Carcinoma | Unresectable Thymic Carcinoma | Metastatic Thymic Carcinoma , Carboplatin and Paclitaxel With or Without Ramucirumab in Treating Patients With Locally Advanced Recurrent or Metastatic Thymic Cancer That Cannot Be Removed by Surgery
A single mutation in the transcription factor GTF2I may help differentiate fast-growing cancers of the thymus that require aggressive treatment from slow-growing ones that dont require extensive therapy, according to a study published in Nature Genetics.. Conducted by researchers from Georgetown Lombardi Comprehensive Cancer Center in Washington, DC, and the NCI, the study involved thymic epithelial tumors (TET), which are subdivided into thymomas and thymic carcinomas; thymomas are further classified into types A, AB, B1, B2, and B3 based on histological features. All begin in the epithelial cells of the thymus, a lymphatic system organ where T cells mature. Together, they account for only 0.2% to 1.5% of all cancers.. In addition to being rare, there is an insufficient characterization of the genetic abnormalities in these tumors, says the studys senior investigator Guiseppe Giaccone, MD, PhD, associate director for clinical research at Georgetown. Having a GTF2I mutation as a marker ...
Thymic epithelial tumors (TET) are rare. Wingless and INT (WNT), NOTCH and sonic hedgehog pathway interactions between thymocytes and thymic stroma are important to thymus and T-cell development. We analyzed a thymoma tissue microarray (TMA) for glioma associated oncogene homolog 1 (GLI1), NOTCH1 and catenin (cadherin-associated protein, beta 1) (CTNNB1) expression as surrogate markers of sonic hedgehog, NOTCH and WNT pathway activity.GLI1, NOTCH1 and CTNNB1 expression were assayed in a tissue microarray of 68 TET and eight benign thymus by fluorescent immunohistochemistry (AQUA) as surrogates for activity of the sonic hedgehog, NOTCH and WNT pathways respectively.No difference in tumor GLI1 (mean 201 vs. 211, p=0.31), CTNNB1 (mean 222 vs. 306, p=0.66) or NOTCH1 expression (mean 317 vs. 325, p=0.82) was noted between thymic tumor and benign thymus.No evidence for preferential expression of GLI1, NOTCH1 or CTNNB1 was noted. High-throughput immunofluorescence using AQUA technology can help ...
A risk factor is something (such as a behaviour, substance or condition) that increases the risk of developing cancer. There are no known risk factors for thymic tumours, but there are some possible risk factors. Most cancers are the result of many risk factors, but sometimes thymic tumours develop
article{Mediastinum4558, author = {Kwon Joong Na and Samina Park and In Kyu Park and Young Tae Kim and Chang Hyun Kang}, title = {AB010. OA02.01: Comparison of factors affecting length of stay after surgery for thymic tumors: minimally invasive vs . open surgeries}, journal = {Mediastinum}, volume = {2}, number = {0}, year = {2018}, keywords = {}, abstract = {}, url = {http://med.amegroups.com/article/view/4558 ...
The doctor mentioned in the article, Patrick Loehrer, Alan actually contacted him a year ago and they DO correspond. He is the expert but unfortunately he sees mostly thymomas - there isnt too much thymic to see. SO his work and trials are geared to thymomas. This is the problem.. All of the oncologists we talk to know that the mix he uses is extremely toxic and it may be of some value in thymomas [hes seen more than any other dr.]. But the protocol is not proven for thymic cancers. They dont know if it works at all for thymic. Unfortunately. It is so toxic due to the combination they choose, that most patients cant finish the series due to extreme side affects and many of the others die at the end [Johns Hopkins did a study]. SO that is why the oncologists say until I absolutely need it, theyd like to wait. We are tending to agree. I dont want to end up like my mother where the treatment killed her. It almost happened with the radiation last year.. There has to be a better way.. He has ...
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Affiliation:東京女子医科大学,医学部,教授, Research Field:Obstetrics and gynecology,Hygiene, Keywords:フリーラジカル,胎児脳神経障害,アロプリノール,NMDAレセプター,臍帯,モンテビオ単位,子宮筋弛緩剤,胎児(仔)呼吸様運動,パワー値,umbilical cord, # of Research Projects:5, # of Research Products:8
The objective of this study was to re-examine histologically and restage thymic epithelial tumours during a 25-year period and to correlate clinical and follow-up data. We utilized centralized registries in Iceland to establish a true nationwide incidence rate, previously unreported. A retrospective whole population study was carried out by including all patients diagnosed with a thymic epithelial tumour in Iceland between 1 January 1984 and 30 April 2010. Medical records were reviewed and presenting symptoms, diagnostic procedures and surgical outcome tabulated. The histology of all cases was reclassified according to the 2004 World Health Organization classification (A-TC). The Masaoka system was used for tumour staging. Median follow-up was 67 months. A total of 19 patients were identified, 11 men (58%) and 8 women, with mean age at presentation of 63 years (31-87 years). The age-standardized incidence rate (ASR) was 0.3 and 0.2/100 000/year for men and women, respectively. Types B2 (n = 5) ...
TY - JOUR. T1 - Phase II study of carboplatin and paclitaxel in advanced thymoma and thymic carcinoma. AU - Lemma, Girum L.. AU - Lee, Ju Whei. AU - Aisner, Seena C.. AU - Langer, Corey J.. AU - Tester, William J.. AU - Johnson, David H.. AU - Loehrer, Patrick J.. PY - 2011/5/20. Y1 - 2011/5/20. N2 - Purpose: The purpose of this study was to evaluate the impact of carboplatin and paclitaxel in patients with advanced previously untreated thymoma and thymic carcinoma. Patients and Methods We conducted a prospective multicenter study in patients with unresectable thymoma (n = 21) or thymic carcinoma (n = 23). Patients were treated with carboplatin (area under the curve, 6) plus paclitaxel (225 mg/m2) every 3 weeks for a maximum of six cycles. The primary end point of this trial was to evaluate the objective response rate. Results: From February 2001 through January 2008, 46 patients were enrolled. Thirteen patients had grade 4 or greater toxicity, mostly neutropenia. Using RECIST (Response ...
The present study aimed to investigate the expression and association of the single-nucleotide polymorphism (SNP) -1637A/G in the promoter region of the T cell immunoglobulin domain and mucin domain protein-1 (Tim-1) gene in patients diagnosed with thymoma with or without myasthenia gravis (MG). The expression of Tim-1 was detected using the streptavidin peroxidase immunohistochemical staining method on tissues obtained from thymoma patients with (n=58) and without (n=62) MG. The Tim-1 gene -1637A/G polymorphism was detected using the single allele-specific primer polymerase chain reaction. The positive rate of Tim-1 expression in thymoma patients with MG was 62.1% (32/58), which was significantly higher compared with that in thymoma patients without MG (33.9%, 21/62) (P=0.002). The genotype frequencies of GG, GA and AA in the -1637A/G polymorphism were 0.7931, 0.2069 and 0, respectively, in thymoma patients with MG, and 0.6129, 0.3871 and 0, respectively, in thymoma patients without MG. A ...
pISSN 1738-1843 eISSN 2092-8920 © 2013 The Korean Society of Pathologists/The Korean Society for Cytopathology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Thymolipoma is a rare anterior mediastinal tumor composed of mature adipose tissue and benign thymic tissue, and is a benign neoplasm for which complete surgical excision is curative. Literature has reported that the thymic parenchyma of thymolipoma exceptionally contain myoid cells that are immunoreactive for desmin, muscle-specific actin and myoglobin. Herein, we describe a very rare case of thymolipoma with myoid cells. To the best of our knowledge, this is the sixth case of thymolipoma containing striated myoid cells in the English literature since 1972.
The present study retrospectively examined the diagnostic utility of adding positron emission tomography (PET) or magnetic resonance imaging (MRI) to computed tomography (CT) alone for preoperative diagnosis of anterior mediastinal tumors. A total of 104 consecutive patients who had undergone surgical resection of anterior mediastinal tumors were divided into two groups: Additional PET to another modality and no additional PET to another modality, and further subdivided into three groups: CT alone, additional MRI to CT and additional PET to CT. The sensitivity, specificity, and accuracy for diagnosing malignant tumors in each subgroup was calculated. Comparing the two groups, the diagnostic sensitivity was similar for additional PET (98.0%) and no additional PET (95.2%) groups; however, the specificity and accuracy for additional PET (75.0 and 92.2%, respectively) were significantly improved compared with no additional PET (31.6 and 65.0%, respectively). In the subgroup analysis, adding PET to ...
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Thymoma and thymic carcinoma originate within the epithelial cells of the thymus, resulting in an anterior mediastinal mass. The term thymoma is customarily used to describe neoplasms that show no overt atypia of the epithelial component, whereas, a thymic epithelial tumor that exhibits clear-cut cytologic atypia and...
ABSTRACT. Background: We reported our experience with thymic carcinomas and review their clinical features, treatment strategies, and prognoses. Methods: From April 1998 to November 2012, 11 patients pathologically diagnosed with thymic carcinoma and treated in our hospital were investigated. Results: There were 7 men and 4 women, with a median age of 62 years (range, 35 - 72). According to the Masaoka staging system, 3 patients had stage II, 1 stage III disease, 3 stage IVa disease and 4 stage IVb disease. Ten patients had squamous cell carcinoma, whereas 1 had large cell neuroendocrine carcinoma (LCNEC). We performed surgery or multimodality therapy including surgery as the initial therapy for 8 patients. Of the non-surgical cases, 1 patient received chemoradiotherapy and survived for over 6 years without recurrence, whereas 2 received palliative care. Three of 4 patients who underwent complete resection survived without disease recurrence, whereas only 1 patient with LCNEC survived in the ...
Disease Overview Thymomas and thymic carcinomas are epithelial tumors of the thymus. The term, thymoma, is customarily used to describe neoplasms that show no overt atypia of the epithelial component. A thymic epithelial tumor that exhibits clear-cut cytologic atypia and histologic features no longer specific to the...
In 1999, the World Health Organization (WHO) Consensus Committee published a histologic classification of tumors of the thymus. In this scheme, thymomas are classified on the combined basis of the morphology of the neoplastic epithelial cells and the lymphocyte-to-epithelial cell ratio. This classification has resulted in six separate histologic subtypes of thymomas (types A, AB, B1, B2, B3, and C) (Table 7-1). An update on the WHO classification was published in 2004.27 It retained its classifications of A through B3 thymomas but relegated type C to a separate category of thymic carcinoma and acknowledged that certain types of thymoma do not fall into these categories. The applicability and clinical significance of the WHO histologic classification of thymomas is still being evaluated. It appears that most thymomas can be classified using the WHO criteria, although the clinical and prognostic relevance of this classification has not been conclusively determined. Most thymomas of types A and AB ...
Introduction: Thymic malignancies represent a wide range of clinical, histological and molecular entities, with considerable heterogeneity even among tumors of the same histotype. Thymomas are rare neoplasms arising from tissue elements of the thymus and developing in the anterior mediastinum, with an annual incidence of only 0.15 cases per 100, 000 person-years. They can be associated with a variety of systemic and autoimmune disorders, such as pure red cell aplasia, pancytopenia, hypogammaglobulinemia, collagen-vascular disease, and most commonly with myasthenia gravis. Surgical resection remains the cornerstone of therapy for early-stage disease, while in advanced or recurrent forms, a multimodality approach incorporating radiation and chemotherapy is required. Platinum with anthracycline-based chemotherapy is an optimal combination for advanced thymoma. Case Report: We hereby present an interesting case of thymoma which was detected on imaging for routine health check-up and was managed successfully
Background: Mediastinal masses are relatively uncommon lesions that sometimes pose an interesting diagnostic and therapeutic problem for the clinician. Thymomas are one of the common mediastinal neoplasms and exhibit a wide spectrum of morphologic features and an unrivalled frequency of other autoimmune diseases. The great morphologic variability and heterogeneity in thymomas has rendered their histological classification difficult and highly controversial. Methods: This retrospective and descriptive study on thymoma was done in the department of pathology, Kasturba Medical College Mangalore (Manipal University), India over a period of five years from January 2006 to June 2011. Histopathology sections taken were stained with routine Hematoxylin and Eosin stains in every case. Additional stains and immunohistochemistry were done as required. Results: Total number of mediastinal lesions studied was 66, with thymomas making up 15 cases. The age range of patients with thymomas was 22 to 65 years ...
Here we describe, to our knowledge, the first case where an evolution of mechanisms responsible for hypercalcemia occurred in undifferentiated thymic carcinoma and discuss specific management strategies for hypercalcemia of malignancy (HCM).|i| Case Description|/i|. We report a 26-year-old male with newly diagnosed undifferentiated thymic carcinoma associated with HCM. Osteolytic metastasis-related hypercalcemia was presumed to be the etiology of hypercalcemia that responded to intravenous hydration and bisphosphonate therapy. Subsequently, refractory hypercalcemia persisted despite the administration of bisphosphonates and denosumab indicative of refractory hypercalcemia. Elevated 1,25-dihydroxyvitamin D was noted from the second admission with hypercalcemia responding to glucocorticoid administration. A subsequent PTHrP was also elevated, further supporting multiple mechanistic evolution of HCM. The different mechanisms of HCM are summarized with the role of tailoring therapies based on the particular
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The intent of the study is to assess the antitumor activity of PHA-848125AC in patients with recurrent or metastatic, unresectable malignant thymoma pre
Myasthenia gravis is the best known autoimmune disease associated with thymomas, but other conditions can be found in patients with thymic tumors, including some that affect the central nervous system (CNS). We have become particularly interested in patients who have acquired neuromyotonia, the rare Morvan disease, or limbic encephalitis. Neuromyotonia mainly involves the peripheral nerves, Morvan disease affects both the peripheral nervous system and CNS, and limbic encephalitis is specific to the CNS. Many of these patients have voltage-gated potassium channel autoantibodies. All three conditions can be associated with thymomas and may respond to surgical removal of the underlying tumor together with immunotherapies and symptomatic treatments. Herein, we review the results of our recent studies that show that voltage-gated potassium channel autoantibodies are not principally directed against the potassium channels themselves but in some patients are directed against a protein that is complexed with
Epidermal growth factor receptor, c-kit, and her2/neu immunostaining in advanced or recurrent thymic epithelial neoplasms staged according to the 2004 world health organization in patients treated with octreotide and prednisone: an eastern cooperative oncology group study Academic Article ...
Thymoma and thymic carcinoma are diseases in which malignant (cancer) cells form on the outside surface of the thymus. The thymus, a small organ that lies in the upper chest under the breastbone, is part of the lymph system. It makes white blood cells, called lymphocytes, that protect the body against infections...
Learn about thymoma and thymic carcinoma, two cancers affecting the thymus. Its a small gland that makes white blood cells that fight infection.
IUCRO-0031; Molecular and Pathological Correlates of Treatment Outcome in Patients with Thymoma and Thymic Carcinoma study is currently recruiting healthy volunteers at Indiana CTSI, IN
thymomas WP WebPathology PO Definition: Thymoma is the most frequent tumor arising in human thymus (thymic tumors). Thymoma is a tumor (...)
The main characteristics of the patients included in this study are shown in Table 1. Tumor histology has been classified according to the World Health Organization (WHO) proposal.16 The majority of the patients received thymectomy and showed an inversion of the CD4+/CD8+ ratio. Five patients were suffering from severe immunodeficiency syndrome characterized by recurrent infections of the lower respiratory tract. Flow cytometry analyses were performed at monthly intervals in the last 6 months, showing a stable reduction of mature CD19+ peripheral cells (unique patient numbers [UPNs] 091, 157, 051, 009, 147). A marked hypogammaglobulinemia had been detected in 4 of the 5 patients, whereas 1 of them (UPN 091) had normal immunoglobulin (Ig) serum levels. On the bases of clinical signs and B lymphopenia, we classified these patients as suffering from Good syndrome. We included in the study also 2 thymoma patients with normal Ig serum levels, normal B-cell counts, and no signs of severe recurrent ...
Thymomas are usually benign tumors, but they can also be malignant. Thymomas are rare tumors often associated with an autoimmune disease, the most common of which is myasthenia gravis.
Thymomas comprise about 1% of all mediastinal tumours and are rare in children. Typically, these tumours are aggressive, with a poor outcome. The current treatment of invasive thymoma is often multidisciplinary. We report a 16-year-old boy with invasive thymoma who was successfully treated with systemic chemotherapy, surgical resection and irradiation. The patient has been in continuous remission for 6 years without radiographic evidence of tumour recurrence.. ...
/PRNewswire/ -- Castle Biosciences Inc. today announced data from a study of a genetic test demonstrating high accuracy in differentiating thymomas from thymic...
Find the best thymomas doctors in Mumbai. Get guidance from medical experts to select thymomas specialist in Mumbai from trusted hospitals - credihealth.com
Treatment protocols for thymoma are provided below, including treatment by Masaoka clinical stage, chemotherapy regimens, recommendations for recurrent or metastatic disease, and radiotherapy regimens. Treatment recommendations based on Masaoka clinical stage Stage I: Complete surgical excision is the treatment of choice for nonmetastatic t...
Factors influencing the length of stay after mediastinal tumor resection in the setting of an enhanced recovery after surgery (ERAS)-TUBELESS protocol
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Diarrhoea is a common symptom for which the aetiology will be straightforward in many cases. However, when a common aetiology is not found, the wide variety of other options can feel like finding a needle in a haystack. In this case report, we describe a patient who was referred to our centre with therapy-resistant, secretory diarrhoea, which was the presenting symptom of Goods syndrome, a rare form of adult-onset immunodeficiency associated with thymoma. The conclusions from this case report give direction for finding the needle and contribute to a focused approach to patients who present with therapyresistant diarrhoea ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
This video demonstrates how safe and fast a robotic excision of thymic carcinoma along with an extended thymectomy and the excision of affected pericardium can be, compared to a standard median... More ...
Patient ID: 703/19, Format: FFPE, Type: Tumor, Sample Vol mL: , Gender: Male, Age: 32, Race: Caucasian, Ethnicity: Slavic, Organ: Mediastinum, Clinical Diagnosis: Mediastinal carcinoma, Pathological Diagnosis: Malignant epithelioid tumor (probably Thymoma B3 type), need IHC, T, N, M = T3, Nx, Mx, Grade: G1, Stage: III, Lymph Node Metastases: no, Distant Metastasis: no, Tumour = 80%, Necrosis = 0%, Hours & Minutes before fixation in formalin = 015, HIV = Neg, HEP B = Neg, HEP C = Neg, Patients Height: cm, Patients Weight: kg, Current Medications: , Smoking: , Smoking Type: , Smoking Pack/Day = , Smoking Duration Years = , Smoking When Quit: , Alcohol: , Drug Use: , Hormonal Therapy: no, Prev Chemotherapy: no, Prev Radiation: no, Current Procedure/Operation: resection, Date of Procurement: 43556, Country of Collection: Georgia
Light micrograph of normal human thymus. The thymus is divided into lobules separated by septa of connective tissue (white spaces) which may contain blood vessels (as at right, stained red and very dark purple). Each lobule has a cortex (granular masses, densley packed, picture periphery) of lymphocytes, and a medulla (centre) of lymphocytes and stellate epitherial cells. The circular pink structures within the medulla (one prominent) are concentrically arranged epitherial cells of uncertain function. Magnificaton: x20 at 35mm size. - Stock Image P264/0004
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Thymoma is a neoplasm of thymic epithelial cells. This definition excludes other tumors that may affect the thymus, such as lymphoma and germ cell tumors.
Dr. Michael Thompson answered: Thymus: A thymoma is a tumor of the thymus, a gland in the anterior chest. This gland is present as ...
Diagnosis of thymoma (costs for program #273927) ✔ University Hospital Ulm ✔ Department of General and Abdominal Surgery ✔ BookingHealth.com
article{{Mediastinum}{4556}, author = {Casini, B., Sarti, D., Gallo, E., Alessandrini, G., Cecere, F., Pescarmona, E., Facciolo, F., Marino, M.}, title = {AB008. OA01.08: Thymic carcinoma: preliminary data of next generation sequencing analysis}, journal = {Mediastinum}, volume = {2}, number = {0}, year = {2018}, url = {http://med.amegroups.com/article/view/4556 ...
Csh1 245 -3.31E+00 Melk 246 -3.30E+00 1459742_at 247 -3.30E+00 Nmnat3 248 -3.30E+00 A930015G24Rik 249 -3.29E+00 2810417H13Rik 250 -3.29E+00 Mrgprb1 251 -3.29E+00 1700061G19Rik 252 -3.29E+00 1459554_at 253 -3.28E+00 14378G7_at 254 -3.27E+00 Ceacam13 255 -3.27E+00 A130019P10Rik 256 -3.27E+00 Aqp11 257 -3.27E+00 2310047C04Rik 258 -3.27E+00 Dpp4 259 -3.27E+00 Otud1 260 -3.27E+00 1442468_at 261 -3.26E+00 B230101F01Rik 262 -3.26E+00 Tal2 263 -3.26E+00 Cplx1 264 -3.26E+00 Slc25a27 265 -3.26E+00 Spsb4 266 -3.25E+00 Mtm1 267 -3.25E+00 Bambi-ps1 268 -3.25E+00 1432510_ai 269 -3.25E+00 Pcmtd2 270 -3.25E+00 Clec2h 271 -3.24E+00 4930535E21Rik 272 -3.24E+00 1457234_at 273 -3.24E+00 Gm172 274 -3.23E+00 Gm996 275 -3.22E+00 E130014H08Rik 276 -3.22E+00 H2afy2 277 -3.22E+00 Defb3 278 -3.21E+00 Rbbp8 279 -3.20E+00 Dnase1l2 280 -3.19E+00 Sesn1 281 -3.19E+00 Accn3 282 -3.18E+00 4921537P18Rik 283 -3.18E+00 Hsd17b13 284 -3.18E+00 1810044A24Rik 285 -3.18E+00 Gas5 286 -3.18E+00 Flcn 287 -3.17E+00 Igh-4///Igh-6///Igh-V 288 ...
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The MEN1 phenotype is inherited via an autosomal-dominant pattern and is associated with neoplasms of the pituitary gland, the ... Less frequently, neuroendocrine tumors of lung, thymus, and stomach or non-endocrine tumors such as lipomas, angiofibromas, and ... ependymomas are observed neoplasms. In a study of 12 sporadic carcinoid tumors of the lung, five cases involved inactivation of ...
8560-8580) Complex epithelial neoplasms. Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that ... 2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ... and imaging studies in a logical fashion to obtain information about the size of the neoplasm and the extent of its invasion ... or other notable characteristics consistent with a more highly differentiated neoplasm. ...
T-Cell Lymphoblastic Leukemia (T-ALL) is a type of acute lymphoblastic leukemia with aggressive malignant neoplasm of the bone ... Patients with immature thymocytes in the thymus begins T-ALL development. Furthermore, hereditary conditions such as Down ... T-ALL is a precursor for lymphoid neoplasm. Its clinical presentation most commonly includes infiltration of the central ... nervous system (CNS), and further identifies mediastinal mass presence originating from the thymus, along with extramedullary ...
... a malignant neoplasm of thymus ICD-10 code Caldwell 37 (NGC 6885), an open cluster in the constellation Vulpecula This ...
EMH in the lymph nodes is usually associated with underlying hematopoietic neoplasms. Myeloproliferative neoplasms (MPNs) tend ... The following tissues may also be associated with EMH: thymus, heart, breast, prostate, fatty tissue, adrenal glands, kidney, ... Other manifestations occur in the thymus, heart, breast, prostate, broad ligaments, kidneys, adrenal glands, pleura, ... para-nasal sinuses and numerous types of benign/malignant neoplasms. The most common sites of EMH associated with neoplastic ...
... mental retardation Thymic carcinoma Thymic epithelial tumor Thymic renal anal lung dysplasia Thymoma Thymus neoplasm ... Temtamy-Shalash syndrome TEN Ter Haar-Hamel-Hendricks syndrome Ter Haar syndrome Teratocarcinosarcoma Teratoma Testes neoplasm ... syndrome Tolosa-Hunt syndrome Toluene antenatal infection Tomaculous neuropathy Tome-Brune-Fardeau syndrome Tongue neoplasm ... Trisomy 14 mosaicism Trisomy 2 mosaicism Trisomy 3 mosaicism Trisomy 6 Trisomy Trochlear dysplasia Trophoblastic Neoplasms ( ...
ISBN 0-7020-2606-9. Huete-Garin, A.; S.S. Sagel (2005). "Chapter 6: "Mediastinum", Thymic Neoplasm". In J.K.T. Lee; S.S. Sagel ... Thymus of a fetus On chest X-ray, the thymus appears as a radiodense (brighter in this image) mass by the upper lobe of the ... In children the thymus is grayish-pink in colour and in adults it is yellow. The thymus consists of two lobes, merged in the ... The thymus is largest and most active during the neonatal and pre-adolescent periods. By the early teens, the thymus begins to ...
... unspecified 163 Malignant neoplasm of pleura 164 Malignant neoplasm of thymus, heart, and mediastinum 165 Malignant neoplasm of ... 140 Malignant neoplasm of lip 141 Malignant neoplasm of tongue 142 Malignant neoplasm of major salivary glands 143 Malignant ... benign neoplasm of uterus 220 Benign neoplasm of ovary 221 Benign neoplasm of other female genital organs 222 Benign neoplasm ... neoplasm of oropharynx 147 Malignant neoplasm of nasopharynx 148 Malignant neoplasm of hypopharynx 149 Malignant neoplasm of ...
... is a very rare malignant neoplasm originating from bronchial glands. It is classified as a ... 2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ...
2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ... Berman JJ (November 2004). "Tumor taxonomy for the developmental lineage classification of neoplasms". BMC Cancer. 4 (1): 88. ... system lists a number of morphological subtypes and variants of malignant squamous cell neoplasms, including: Papillary thyroid ...
Historically, mature histiocytic and dendritic cell (HDC) neoplasms have been considered mature lymphoid neoplasms, since these ... CD7 It often presents as a mediastinal mass because of involvement of the thymus. It is highly associated with NOTCH1 mutations ... lymphoma classification should reflect in which lymphocyte population the neoplasm arises. Thus, neoplasms that arise from ... Lymphoma classification update: T-cell lymphomas, Hodgkin lymphoma, and histiocytic/dendritic cell neoplasms. Expert Rev ...
Myeloid neoplasms always concern bone marrow cell lineage and are related to hematopoietic cells. Myeloid tissue can also be ... is not complete until they migrate to lymphatic organs such as the spleen and thymus for programming by antigen challenge. Thus ...
Comparison of Neoplasms in Six Sources of Rats *^ Diamond JM (January 2006). Collapse: How Societies Choose to Fail or Succeed ... Rowett nudes, first identified in 1953 in Scotland, have no thymus. The lack of this organ severely compromises their immune ... A 1972 study compared neoplasms in Sprague Dawley rats from six different commercial suppliers and found highly significant ... they can suffer from high incidences of neoplasms, with the rat's lifespan mainly determined by this. The most common are ...
2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ... Berman JJ (November 2004). "Tumor taxonomy for the developmental lineage classification of neoplasms". BMC Cancer. 4: 88. doi: ... Squamous cell carcinoma of eye tissues is one of the most frequent neoplasms of cattle. On third eyelid, papilloma-like (see ...
Bernatz lectured actively and internationally on the surgery of the thymus, in the latter part of the twentieth century. He ... Kaiser LR: Surgical treatment of thymic epithelial neoplasms. Hematol Oncol Clin North Am 2008; 22: 475-488. Skeie GO, Romi F: ... Bernatz, PE (1970). "Surgery of the thymus". J Miss State Med Assoc. 11 (12): 629-633. PMID 5490391. Bernatz PE, Khonsari S, ... Bernatz rapidly acquired clinical experience with the treatment of thymoma, a potentially-aggressive mediastinal neoplasm which ...
Comparison of Neoplasms in Six Sources of Rats Diamond JM (January 2006). Collapse: How Societies Choose to Fail or Succeed. ... have no thymus. The lack of this organ severely compromises their immune system, with infections of the respiratory tract and ... The Lewis rat suffers from several spontaneous pathologies: first, they can suffer from high incidences of neoplasms, with the ... Play media A 1972 study compared neoplasms in Sprague Dawley rats from six different commercial suppliers and found highly ...
G1 and G2 neuroendocrine neoplasms are called neuroendocrine tumors (NETs) - formerly called carcinoid tumours. G3 neoplasms ... NETs include certain tumors of the gastrointestinal tract and of the pancreatic islet cells, certain thymus and lung tumors, ... Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common ... Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. They most ...
2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ... Large cell neuroendocrine carcinoma of the lung (LCNEC) is a highly malignant neoplasm arising from transformed epithelial ...
CD3 is initially expressed in the cytoplasm of pro-thymocytes, the stem cells from which T-cells arise in the thymus. The pro- ... and can therefore be used to distinguish them from superficially similar B-cell and myeloid neoplasms. Zheng L, Lin J, Zhang B ...
Originally we treated dogs with Thymosin (derived from bovine thymus) because of reports of its effectiveness in human LCH ... histiocytic neoplasm which arises in multiple sites simultaneously. Most lesions previously defined as MH are probably more ... cutaneous neoplasm in dogs. Histiocytomas usually occur as solitary lesions, which spontaneously regress, and seldom recur. ...
"Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart". World Health Organization Classification of Tumours. ... has proved that lung cancers should be considered an extremely heterogeneous family of neoplasms with widely varying genetic, ... 2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ...
Travis, W.D.; Brambilla, B.; Burke, A.P; Marx, A.; Nicholson, A.G. WHO Classification of Tumours of the Lung, Pleura, Thymus ... nuclear pleomorphism is one of the earliest hallmarks of cancer progression and a feature characteristic of malignant neoplasms ...
"Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart". World Health Organization Classification of Tumours. ... Adenocarcinomas are exceptionally heterogeneous neoplasms, occurring in four major tissue architectures (acinar, papillary, ... 2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ...
Carcinoma is a term for malignant neoplasms derived from cells of epithelial lineage, and/or that exhibit cytological or tissue ... 2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ...
Although it is not normally considered a fast-growing malignant neoplasm, FA can exhibit high uptake on FDG-PET scanning. ... 2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ... "Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart". World Health Organization Classification of Tumours ...
Kendall, M. D (1989). "The morphology of perivascular spaces in the thymus". Thymus. 13 (3-4): 157-64. PMID 2694455. Edelman, E ... These disorders are: cystic neoplasms lacunar infarctions cystic periventricular leukomalacia cryptococcosis multiple sclerosis ... Perivascular spaces, especially around fenestrated capillaries, are found in many organs, such as the thymus, liver, kidneys, ...
... , along with CD25, is used to track early T cell development in the thymus. CD44 expression is an indicative marker for ... On the contrary, in some neoplasms CD44 upregulation is associated with a favorable outcome. This is true of prostate cancer, ... and CD44-soluble proteins markedly reduces the malignant activities of various neoplasms, stressing the therapeutic potential ...
Janeway, H. H. (1920). The treatment of malignant tumors of the thymus gland by radium. Annals of surgery, 71(4), 460. Janeway ... A Model for a Curable Neoplasm" 2010 Charles M. Balch, M.D., Johns Hopkins Medical Institute - "Melanoma as an Example of ... "What the Study of Leukemia has Taught Us about the Common Neoplasms" 1995 Lester J. Peters, M.D., East Melbourne, Australia - " ...
Approximately 98% of lung cancers are carcinoma, a term for malignant neoplasms derived from cells of epithelial lineage, and/ ... 2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ...
... thymus, lymph node, ovarian, muscle, lung, blood, and kidney tissues. The translated TMEM229B protein is a total of 167 amino ... B-cell neoplasm, breast carcinoma, Burkitt's lymphoma, colorectal adenocarcinoma, carcinoma, cutaneous T cell lymphoma, ...
Also functions in very early stages of kidney organogenesis, the müllerian system, and the thymus.[7] Additionally, PAX8 is ... aka Hurthle-Cell Neoplasms).[15] Tumors expressing the PAX8/PPARy are usually present in at a young age, small in size, present ...
... thymus - tissue - titer - toxicity - toxoplasmic encephalitis - toxoplasmosis - transaminase - transcription - transfusion - ... neoplasm - nephrotoxic - neuralgia - neurological complications of AIDS - neuropathy - neutralization - neutralizing antibody ...
... tumors may rarely arise from the ovary or thymus.[2]. They are most commonly found in the midgut at the level of the ... cystic neoplasms: Serous microcystic adenoma. *Intraductal papillary mucinous neoplasm. *Mucinous cystic neoplasm ...
2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ... Large cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms originating from transformed ... in that the tumor cells lack light microscopic characteristics that would classify the neoplasm as a small-cell carcinoma, ...
D. Noël Paton, The relationship of the thymus to the sexual organs II. The influence of removal of the thymus on the growth of ... Tseng-Tong Kuo, Classification of thymic epithelial neoplasms: a controversial issue coming to an end?, J.Cell.Mol.Med. 5. ... 1. Thymus. Compt rend hebdom Soc Bioi 9: 5, 1893. *Prenant A (1894) Contribution a I'etude organique et histologique du thymus ... JAMES HENDERSON, ON THE RELATIONSHIP OF THE THYMUS TO THE SEXUAL ORGANS. 1. The Influence of Castration on the Thymus., (From ...
Lung cancer is an extremely heterogeneous family of malignant neoplasms,[1] with well over 50 different histological variants ... Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press: Lyon 2004. ... Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. ...
Abscess of thymus. *Absent adrenal gland. *Acanthamoeba infection. *Acanthamoeba keratitis. *Acantholytic dyskeratotic ... Adipose tissue neoplasm. *Adiposis dolorosa. *Adiposogenital dystrophy. *Adipsia. *Adjustment disorder. *Adnexal and skin ...
Thymus: Thymosin (Thymosin α1, Thymosin beta) · Thymopoietin · Thymulin Digestive system: Stomach: gastrin · ghrelin · Duodenum ... Geenen V, Legros JJ, Franchimont P, Baudrihaye M, Defresne MP, Boniver J (1986). "The neuroendocrine thymus: coexistence of ... oxytocin and neurophysin in the human thymus". Science. 232 (4749): 508-11. doi:10.1126/science.3961493. PMID 3961493.. Unknown ...
A prominent thymus, which can give the impression of a widened mediastinum.[10] ... neoplasm: e.g., metastases, lymphoma, hamartoma. *sarcoidosis. *alveolitis. *auto-immune disease: e.g., granulomatosis with ... The many facets of normal paediatric thymus". South African Journal of Radiology. 19 (1). doi:10.4102/sajr.v19i1.803. ISSN 2078 ...
More than 1500 different disorders of the skin exist, including cutaneous eruptions ("rashes") and neoplasms. Therefore, ... thymus, spleen, and other lymphoid tissues. In the United States, hematopathology is a board certified subspecialty (licensed ...
A main transcript of 2.8 kb has been described in a large variety of human tissues (pancreas, thymus, adrenal glands, thyroid, ... "Cutaneous tumors in patients with multiple endocrine neoplasm type 1 (MEN1) and gastrinomas: prospective study of frequency and ... an additional transcript of approximately 4 kb has been detected in pancreas and thymus, suggesting a tissue-specific ... Other endocrine and non-endocrine neoplasms including adrenocortical and thyroid tumors, visceral and cutaneous lipomas, ...
... cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type". Ann. Oncol. 21 (5): 1032-40. doi: ... It often presents as a mediastinal mass because of involvement of the thymus.[1] It is highly associated with NOTCH1 mutations. ...
Spivach A, Borea B, Bertoli G, Daris G (July 1976). "[Primary lung neoplasm of rare incidence: giant cell carcinoma]". Minerva ... 2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ... The new paradigm recognizes that lung cancers are a large and extremely heterogeneous family of malignant neoplasms, with over ... Travis WD (November 2010). "Sarcomatoid neoplasms of the lung and pleura". Arch. Pathol. Lab. Med. 134 (11): 1645-58. doi: ...
Its expression is also increased in a wide range of other malignant neoplasms. Factor X (F10) is frequently expressed in normal ... "CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen". Journal of Immunology. 164 (6): 2978-86. doi: ... It is also overexpressed in some cell lines originating from various malignant neoplasms. Thus, it is highly expressed in ... Some of these proteases are overexpressed in malignant neoplasms. For example, transmembrane serine protease 2 (TMPRSS2), which ...
Misago N, Narisawa Y (September 2006). "Cytokeratin 15 expression in neoplasms with sebaceous differentiation". Journal of ... Thymus. 3 (3): 153-67. PMID 6171918. Polakowska RR, Piacentini M, Bartlett R, Goldsmith LA, Haake AR (March 1994). "Apoptosis ...
... tracheal neoplasms MeSH C04.588.894.949 - thymus neoplasms MeSH C04.588.894.949.500 - thymoma MeSH C04.588.945.418 - genital ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588. - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ... femoral neoplasms MeSH C04.588.149.721 - skull neoplasms MeSH C04.588.149.721.450 - jaw neoplasms MeSH C04.588.149.721.450.583 ...
Also functions in very early stages of kidney organogenesis, the müllerian system, and the thymus. Additionally, PAX8 is ... aka Hurthle-Cell Neoplasms). Expression of PAX8 is increased in neoplastic renal tissues, Wilms tumors, ovarian cancer and ...
First coined TL (for "thymus-leukemia" antigen in mice) then later as the Ly series (originally named Ly-A and Ly-B and later ... Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA. 1995;92:11810-11813. ... Boyse EA, Old LJ, Luell S. Genetic determination of the TL (thymus-leukemia) antigen in the mouse. Nature 1964; 201:779. Boyse ...
No article was found for Thymus Neoplasms and TET2[original query]. File Formats Help:. How do I view different file formats ( ...
Diagnosis: Thymus, heart and large vessels: thymic carcinoma.. Description: The pre- and supracardial mass measured up to 12.9 ... The aortic and pulmonary root vessels were completely encircled by the neoplasm. Additionally, tumor cells infiltrated the ... Comments: Histological examination identified the neoplasm as a malignant proliferation of thymic epithelial cells with a ...
MIBI: CD3 antibody staining (cyan) of FFPE human thymus, counterstained with dsDNA (magenta) ... and can therefore be used to distinguish them from B-cell and myeloid neoplasms. ...
Chhabra, H., Bose, A., Shivakumar, V., Agarwal, S. M., Sreeraj, V. S., Shenoy, S., Hazari, N., Dinakaran, D., Parlikar, R., Koparde, V., Ramesh, V., Biswal, J., Murugaraja, V., Gowda, S. M., Chand, P. K., Sivakumar, P. T., Kalmady, S. V., Narayanaswamy, J. C., Murthy, P., Girimaji, S. C. & 1 others, Venkatasubramanian, G., 02-2020, In: Psychiatry Research. 284, 112744.. Research output: Contribution to journal › Article › peer-review ...
As previously reported (14), rapamycin treatment led to obvious atrophy from the thymus in wild-type hypophosphorylation and ... not myeloproliferative neoplasm (MPN), induced by oncogenic Kras, indicating that mTORC1 is vital for T-cell advancement and ...
Name: Personal history of other malignant neoplasm of large intestine * Category: Z00 - Z99 ... Name: Personal history of malignant carcinoid tumor of thymus * Category: Z00 - Z99 ...
Trevor, Robert Salusbury Neoplasms Con objetos digitales Opciones avanzadas de búsqueda Encontrar resultados con : ... Body parts examined in the post mortem: Lungs, thymus, thyroid, pericardium, heart, liver, spleen, pancreas, kidneys, bladder, ...
Malignant Neoplasm (cancer): the malignant neoplasms frequency in the mouth is rather high. ... Cancer of thymus*Cancer of heavy intestine: colo-rectal*Cam (complementary and alternative medicine)*Stomach Cancer*Biopsy*ABC ... Mouth: Benign neoplasm: we found several tumors of this type; one of the most frequent is the benign gum tumor or periodontal ...
  • In 1991, Chan and Rosai unified the concept of SETTLE when they described 8 neoplasms situated in the neck and thyroid of children and young adults, previously diagnosed as malignant teratoma of the thyroid, thyroid spindle cell tumor with mucous cysts or thyroid thymoma. (omicsonline.org)
  • It belongs to a group of cervical lesions that includes ectopic cervical thymoma, ectopic hamartomatous thymoma and carcinoma with thymus-like element (CASTLE). (omicsonline.org)
  • Thymoma is a tumor originating from the epithelial cells of the thymus. (icd.codes)
  • The term, thymoma, is customarily used to describe neoplasms that show no overt atypia of the epithelial component. (healthlinkbc.ca)
  • A thymic epithelial tumor that exhibits clear-cut cytologic atypia and histologic features no longer specific to the thymus is known as a thymic carcinoma (also known as type C thymoma). (healthlinkbc.ca)
  • Although rare, malignant thymoma may develop from an ectopic thymus (2) . (ajnr.org)
  • Thymoma originates in the epithelial cells of the thymus. (ebscohost.com)
  • Benign (thymoma) and malignant (thymic lymphoma, thymic carcinoma) neoplasms have been reported. (vetstream.com)
  • Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)
  • A thymic neoplasm can be a thymoma (a tumor of the thymus gland), or thymic carcinoma (a rare type of thymus gland cancer). (upmc.com)
  • A thymoma is a malignant tumor of the thymus, and the seriousness depends on details in the pathology report. (healthtap.com)
  • An ectopic thymus and a hamartoma are both benign, but if the report says "thymoma" then it is probably malignant although not necessarily very serious if completely removed. (healthtap.com)
  • Thymoma generally considered a slow growing form of cancer that begins in the thymus. (healthtap.com)
  • The thymoma is derived from the epithelial cells of the thymus , a rare disease, still famous for its associations with the mysterious neuromuscular disorder called Myasthenia Gravis. (health.am)
  • A thymoma is a type of tumor or growth in the thymus gland. (medicinenet.com)
  • A thymoma is a rare type of tumor of the thymus gland. (medicinenet.com)
  • Thymoma is a type of tumor that originates from the epithelial or lining cells of the thymus. (medicinenet.com)
  • The term thymoma refers to tumors of the thymus that grow slowly and usually do not spread beyond the thymus. (medicinenet.com)
  • Thymoma and thymic carcinoma originate within the epithelial cells of the thymus, resulting in an anterior mediastinal mass. (wellspan.org)
  • Tumors or cancer of the THYMUS GLAND. (sickkids.ca)
  • I have had Breast Cancer, and, irradiation of the thymus gland as an infant. (medhelp.org)
  • Cooper A (1832) The anatomy of the thymus gland. (springer.com)
  • About 10% of those with MG also have thymomas, or benign tumors of the thymus gland. (thefreedictionary.com)
  • The MEN1 phenotype is inherited via an autosomal-dominant pattern and is associated with neoplasms of the pituitary gland, the parathyroid gland, and the pancreas (the 3 "P"s). (wikipedia.org)
  • We report herein the excision of an ectopic parathyroid adenoma which was detected in the thymus gland by gamma probe intraoperatively. (nih.gov)
  • The patient underwent sternotomy and the adenoma was found within the right lobe of the thymus gland with the intraoperative use of gamma probe. (nih.gov)
  • Intraoperative image of an ectopic parathyroid adenoma inside the thymus gland. (nih.gov)
  • An intraoperative image, after a median sternotomy, of an ectopic parathyroid adenoma located within the thymus gland. (nih.gov)
  • Subsequently, the parathyroid adenoma was removed as it was located inside the thymus gland. (nih.gov)
  • Thymic tumors are tumors of the thymus gland. (medicinenet.com)
  • The thymus gland is present in the front of the space between the upper lungs called the anterior mediastinum and behind the upper sternum. (medicinenet.com)
  • The thymus gland is larger during puberty but then normally becomes smaller in adulthood. (medicinenet.com)
  • The thymus is a gland located in the anterior mediastinum (the area between the two lungs and the sternum in the chest) that plays a critical role in the development of immune cells (lymphocytes) during childhood. (medicinenet.com)
  • The thymus gland enlarges during childhood, peaks in size at puberty (about 40 grams), and then begins to shrink. (medicinenet.com)
  • portions of thymus tissue that have been detached from the stalk and left behind in the caudal migration of the gland in embryonic development. (ufrgs.br)
  • Cisplatin-containing chemotherapy is the standard treatment for advanced tumors of the thymus that cannot be removed surgically. (clinicaltrials.gov)
  • New treatment options are needed for patients with advanced tumors of the thymus that do not improve with cisplatin-containing therapy. (clinicaltrials.gov)
  • Thymomas and thymic carcinomas are epithelial tumors of the thymus. (healthlinkbc.ca)
  • World Health Organization pathologic classification of tumors of the thymus and stage correlate with prognosis. (healthlinkbc.ca)
  • Quantitatively it represents 90% of tumors of the thymus. (health.am)
  • The term thymic neoplasms refers to tumors of the thymus, which consist of thymomas and thymic carcinomas. (medicinenet.com)
  • Thymic carcinomas are tumors of the thymus that grow aggressively and may metastasize to distant organs. (medicinenet.com)
  • Some patients with "poorly differentiated neoplasm" or "poorly differentiated carcinoma" of the mediastinum have the i(12p) chromosomal abnormality diagnostic of germ cell tumor. (health.am)
  • Although Merkel cell carcinoma (MCC) exhibits specific clinical and histologic features, differentiation from other cutaneous neoplasms, such as lymphoma, metastatic oat cell carcinoma and malignant melanoma (MM), may sometimes be difficult. (sigmaaldrich.com)
  • Hurtel cell neoplasm can be adenoma (not cancer ) or carcinoma (cancer). (healthtap.com)
  • The clinical and pathologic characteristics of benign and malignant germ cell tumors and of "poorly differentiated carcinoma" of the mediastinum are presented, with special attention focused on the treatment of these neoplasms. (health.am)
  • Fifteen patients had a thymus-related syndrome (in 13 patients it resulted myasthenia gravis ), and in 11 patients it improved or remitted after treatment of the pleural recurrence. (curehunter.com)
  • Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC. World Health Organization Classification of Tumours of the Lung, Pleura, Thymus and Heart . (medscape.com)
  • Utility of immunohistochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum. (semanticscholar.org)
  • We report an immunohistochemical (IHC) panel that includes CD5, placental-like alkaline phosphatase (PLAP), thyroid transcription factor 1 (TTF-1), cytokeratin (CK) 7, CK20, CK5/6, and CD57 for the separation of thymic neoplasms from germ cell tumors (GCTs) and metastatic lung malignancies. (semanticscholar.org)
  • The thoracic diseases including lung cancer, thymus neoplasm, cardiac surgery disease, aortic aneurysm, and mediastinal tumor of nervous tissue are prevalent. (hindawi.com)
  • The main localization of NETs is in the gastroenteropancreatic tract, lung, and, rarely, ovary and thymus ( 1 ). (snmjournals.org)
  • These neoplasms occur mostly in the gastrointestinal tract and pancreas, but can also occur in other tissues including thymus, lung, and other uncommon sites such as ovaries, heart, and prostate. (globenewswire.com)
  • Travis WD, Brambilla E. Burke, et al World Health Organization (WHO) classification of tumours of the lung, pleura, thymus and heart. (eurekaselect.com)
  • My research in thoracic neoplasms has focused on lung cancer, malignant mesothelioma, and mediastinal thymic tumors. (mskcc.org)
  • Extensively revised and expanded, Practical Thoracic Pathology: Diseases of the Lung, Heart, and Thymus (formerly Practical Cardiovascular Pathology ) is a superbly illustrated, one-volume reference to pathology of the thorax. (ebooksmedicine.net)
  • Most thymomas have the potential to behave like a cancer and spread beyond the thymus, but many appear to behave in a benign fashion and are noninvasive. (medicinenet.com)
  • The mediastinum is the site of onset of various types of cancers both of benign and malignant nature, among which thymus tumours and tumours originating from neural elements (neuromas) are the most frequent and treated by the thoracic surgeon . (ieo.it)
  • DRG Group #826-830 - Myeloprolif disord or poorly differentiated neoplasms with major operating room procedure with MCC. (icd.codes)
  • DRG Group #843-845 - Other myeloprolif disorders or poorly differentiated neoplasms diagnoses with MCC. (icd.codes)
  • However, chromogranin A may be absent in poorly differentiated neoplasms. (springer.com)
  • This definition excludes other tumors that may affect the thymus, such as lymphoma and germ cell tumors. (medscape.com)
  • Hodgkin lymphoma and non-Hodgkin lymphoma may also involve the thymus and must be differentiated from true thymomas and thymic carcinomas. (wellspan.org)
  • However, malignant lymphoma is a common spontaneous systemic neoplasm in B6C3F1 mice and the incidence in the concurrent vehicle control group was at the low end of the historical control ranges. (europa.eu)
  • Lymphoma is the most common hematopoietic neoplasm affecting both dogs and cats and results from the malignant transformation of lymphocytes. (dvm360.com)
  • 2 Although lymphoma is considered a common neoplasm, a definitive cause for its development in dogs remains to be determined. (dvm360.com)
  • These first appear in the Peyer's patches and mesenteric lymph nodes and later in the spleen, liver, thymus and other lymph nodes ( Crispens, 1973 ). (jax.org)
  • Thymus pathology embraces a broad spectrum of features, varying from major immunologic abnormalities affecting all organ systems to minor abnormalities with limited clinical consequences. (springer.com)
  • Some individuals with thymus pathology may have all the features of the disease while others may have only a few features. (springer.com)
  • Klöppel G (2011) Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. (springer.com)
  • What Are the Key Statistics about Thymus Cancers? (medlineplus.gov)
  • However, it has not been approved to treat cancers of the thymus. (clinicaltrials.gov)
  • Bone Marrow Neoplasms are cancers that occur in the bone marrow. (meta.org)
  • Doctors use a physical exam, imaging tests, and a biopsy to diagnose thymus cancer. (medlineplus.gov)
  • What Is Thymus Cancer? (medlineplus.gov)
  • Can Thymus Cancer Be Found Early? (medlineplus.gov)
  • What Are the Risk Factors for Thymus Cancer? (medlineplus.gov)
  • Some of these proteins can be found on thymus cancer cells. (clinicaltrials.gov)
  • Researchers want to see if sunitinib can be used to treat advanced thymus cancer. (clinicaltrials.gov)
  • To see if sunitinib is a safe and effective treatment for advanced thymus cancer that has not responded to earlier treatments. (clinicaltrials.gov)
  • Individuals at least 18 years of age who have advanced thymus cancer that has not responded to earlier treatments. (clinicaltrials.gov)
  • Has anyone had a follicular neoplasm which turned out to be cancer of the thyroid? (medhelp.org)
  • Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice. (rupress.org)
  • Thymus cell antigen 1 (Thy1), also known as cluster of differentiation (CD)90, and integrin α6 (ITGA6), also known as CD49f, are important molecules in cancer and putative markers of various stem cell types. (spandidos-publications.com)
  • Is hurtle cell neoplasm defined as cancer? (healthtap.com)
  • Patients with other types of thoracic cancer, such as thymus, may experience similar symptoms. (health.am)
  • A variety of primary and metastatic neoplasms can involve the anterior mediastinum and have similar radiographic or histologic appearances. (semanticscholar.org)
  • It refers to a rare neoplasm that is usually found in the anterior mediastinum. (ebscohost.com)
  • The thymus is a lymphoepithelial organ is mainly located in the anterior mediastinum and a small part is located in the neck. (health.am)
  • These neoplasms are usually located in the anterior mediastinum and discovered during a routine chest x-ray. (wellspan.org)
  • Expression of p63 in thymomas and normal thymus. (semanticscholar.org)
  • In the normal thymus, bone marrow-derived precursor cells destined to become thymocytes (or T lymphocytes) enter the thymus at the corticomedullary junction and differentiate as they pass through the thymus. (medscape.com)
  • Mediastinal tumors can be developped in the mediastinum - the area of the chest that separates the lungs and contains the heart, aorta, esophagus, thymus, and trachea. (ieo.it)
  • Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin (derived from bone marrow resident hematopoietic stem cells). (wikipedia.org)
  • The thymus provides an inductive environment for development of T cells from hematopoietic progenitor cells. (wikipedia.org)
  • Niche functionality is likely affected not only by the genomic background of the myeloproliferative neoplasm-associated mutated hematopoietic stem cells, but also by disease-associated 'chronic inflammation', and subsequent adaptive and innate immune responses. (haematologica.org)
  • Philadelphia chromosome negative' myeloproliferative neoplasms (MPN) are a group of relatively rare hematologic diseases characterized by a clonal proliferation of blood cells, most commonly secondary to acquired hematopoietic stem cell (HSC) mutations that directly or indirectly induce upregulation of the JAK-STAT pathway. (haematologica.org)
  • Micrograph showing a Hassall's corpuscle, found within the medulla of the thymus. (wikipedia.org)
  • Thymus cell antigen 1 (Thy1), also known as cluster of differentiation (CD)90, is a 25-37-kDa glycophosphatidylinositol-anchored protein that is expressed in numerous cell types, including T cells, neurons, endothelial cells, fibroblasts and numerous tumor cells. (spandidos-publications.com)
  • 3 ] Thymic carcinomas are rare and have been reported to account for only 0.06% of all thymic neoplasms. (healthlinkbc.ca)
  • We have studied 31 cases of thymomas (12 cortical, 2 predominantly cortical, 5 mixed, and 9 medullary type thymomas as well as 3 well-differentiated thymic carcinomas) and, for comparison, 15 normal thymi, for the presence of different CK polypeptides. (springer.com)
  • Ribonuclease activity in cell-free thymus homogenates was elevated for five strains of mice genetically predisposed toward leukemia or reticulum cell neoplasms (AKR, C58, PL, RF, and SJL). (rupress.org)
  • Most of the tumours are pleomorphic or mixed-cell types commonly called type-B reticulum cell neoplasms by Dunn, but a few are type-A histiocytomas. (jax.org)
  • Immunohistochemistry in the diagnosis of thymic epithelial neoplasms. (semanticscholar.org)
  • Data regarding the prognostic significance of the histopathologic classifications of thymic epithelial neoplasms are contradictory, perhaps reflecting issues in reproducibility. (elsevier.com)
  • The thymus enlarges during childhood, and atrophies at puberty. (wikipedia.org)
  • It is a lowgrade malignant neoplasm, with epithelial differentiation confirmed by immunohistochemical. (omicsonline.org)
  • Neuroendocrine neoplams (NENs) are neoplasms with a broad range of morphologic patterns, grade of differentiation, and biological behavior that share common features of neuroendocrine (NE) programming. (springer.com)
  • Demirkesen C, Hoede N, Moll R: Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins. (springer.com)
  • Tumors arising from neuroendocrine cells are defined as epithelial neoplasms with predominantly neuroendocrine differentiation. (prolekare.cz)
  • The thymus is a specialized primary lymphoid organ of the immune system. (wikipedia.org)
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. (icd10data.com)
  • Gamma probe-assisted excision of an ectopic parathyroid adenoma located within the thymus: case report and review of the literature. (nih.gov)
  • The use of gamma-probe radioactivity consisted of monitoring the thyroid background as a guide, whereas within the thymus high pitch signals in a ratio parathyroid/thyroid = 2.5 were recorded. (nih.gov)
  • Unlike many other organs, the thymus is at its largest in childhood. (wikipedia.org)
  • Its clinical presentation most commonly includes infiltration of the central nervous system (CNS), and further identifies mediastinal mass presence originating from the thymus, along with extramedullary involvement of multiple organs including the lymph node as a result of hyperleukocytosis. (wikipedia.org)
  • In general, mediastinal germ cell tumors appear histologically identical to germ cell tumors arising in the testis, and all histologic subtypes seen in gonadal germ cell neoplasms have also been recognized in the mediastinum. (health.am)
  • The spindle epithelial tumor with thymus-like element (SETTLE) is a very rare neoplasm related to the thyroid of young individuals. (omicsonline.org)
  • The arteries supplying the thymus are branches of the internal thoracic, and inferior thyroid arteries, with branches from the superior thyroid artery sometimes seen. (wikipedia.org)
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified ( C25.9 ). (icd10data.com)
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. (icd10data.com)
  • The thymus is a small organ in your upper chest, under your breastbone. (medlineplus.gov)
  • schließlich wird mit Thymus das in Rede stehende Organ bezeichnet. (springer.com)
  • The thymus is a principal organ of the immune system, and researchers speculate that thymic irregularities are involved in the progression of MG. (thefreedictionary.com)
  • Some may be functional neuroendocrine tumors (NETs) of the gastrointestinal system, lungs, or thymus and release hormones or vasoactive substances. (arupconsult.com)
  • They are much less common than germinal tumors arising in the testes, and account for only 1 to 5% of all germ cell neoplasms. (health.am)
  • In this timely article, we will review current knowledge surrounding the deregulated bone marrow niche in myeloproliferative neoplasms and suggest how this may be targeted, either directly or indirectly, potentially influencing therapeutic choices both now and in the future. (haematologica.org)
  • Discover the latest research on Bone Marrow Neoplasms here. (meta.org)
  • T-Cell Lymphoblastic Leukemia (T-ALL) is a type of acute lymphoblastic leukemia with aggressive malignant neoplasm of the bone marrow. (wikipedia.org)
  • How are neuroendocrine tumors (NETs) of the lungs and thymus graded? (medscape.com)
  • However, for NETs of the lungs and thymus, the WHO includes only mitotic count and assessment of necrosis. (medscape.com)
  • Neuroendocrine neoplasms (NENs) are rare tumors that mainly occur in the gastroenteropancreatic (GEP) tract and lungs. (eurekaselect.com)
  • Category D49 classifies by site neoplasms of unspecified morphology and behavior. (icd10data.com)
  • This review provides a comprehensive overview of the human neuroendocrine system and its neoplasms, from their discovery to current terminology and classifications. (prolekare.cz)
  • Chapter 13 Leukopenia Reactive Prolifera, Chapter 13 Common Forms Of Lymphoid Leuk, Chapter 13 Plasma Cell Neoplasms Disorde, And more! (brainscape.com)
  • Normally, a combination of lymphoid cells (immune cells or lymphocytes) and lining cells (epithelial cells) makes up the thymus. (medicinenet.com)
  • Distinct from adult T-Cell Leukemia where T-Cell Lymphotropic Virus Type I causes malignant maturation of T-cells, T-ALL is a precursor for lymphoid neoplasm. (wikipedia.org)
  • During this descent, remnants of thymic tissue occasionally are implanted along the cervical pathway and may appear later as an ectopic cervical thymus (1) . (ajnr.org)
  • Neuroendocrine tumors (NETs) are a rare and heterogeneous group of neoplasms originating from the neural crest. (snmjournals.org)
  • Neuroendocrine tumors (NETs) are a heterogeneous group of rare neoplasms that originate from neuroendocrine cells. (globenewswire.com)

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