Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.
A plant genus of the family ASTERACEAE. Members contain a pseudoguaiane sesquiterpene. San-fang-feng is the root of E. grijisii used in DRUGS, CHINESE HERBAL.
Methods used for the chemical synthesis of compounds. Included under this heading are laboratory methods used to synthesize a variety of chemicals and drugs.
A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
Inorganic or organic compounds that contain sulfur as an integral part of the molecule.
A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Materials that have a limited and usually variable electrical conductivity. They are particularly useful for the production of solid-state electronic devices.
Electrical devices that are composed of semiconductor material, with at least three connections to an external electronic circuit. They are used to amplify electrical signals, detect signals, or as switches.
A defense mechanism through which unacceptable impulses and instinctive urges are diverted into personally and socially acceptable channels; e.g., aggression may be diverted through sports activities.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Inorganic compounds that contain cadmium as an integral part of the molecule.
Inorganic compounds that contain bromine as an integral part of the molecule.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Unforeseen occurrences, especially injuries in the course of work-related activities.
Databases devoted to knowledge about specific chemicals.
Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Sequential operating programs and data which instruct the functioning of a digital computer.
That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.
An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.
Discrete concentrations of energy, apparently massless elementary particles, that move at the speed of light. They are the unit or quantum of electromagnetic radiation. Photons are emitted when electrons move from one energy state to another. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Treatment using irradiation with LASER light of low power intensity so that the effects are not due to heat, as they are in LASER THERAPY.
Lasers with a semiconductor diode as the active medium. Diode lasers transform electric energy to light using the same principle as a light-emitting diode (LED), but with internal reflection capability, thus forming a resonator where a stimulated light can reflect back and forth, allowing only a certain wavelength to be emitted. The emission of a given device is determined by the active compound used (e.g., gallium arsenide crystals doped with aluminum or indium). Typical wavelengths are 810, 1,060 and 1,300 nm. (From UMDNS, 2005)
The use of photothermal effects of LASERS to coagulate, incise, vaporize, resect, dissect, or resurface tissue.
The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck's constant and v is the frequency of the radiation.
The characteristic three-dimensional shape of a molecule.
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.
Elements with partially filled d orbitals. They constitute groups 3-12 of the periodic table of elements.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Coating with a metal or alloy by electrolysis.
Nanometer sized fragments of semiconductor crystalline material which emit PHOTONS. The wavelength is based on the quantum confinement size of the dot. They can be embedded in MICROBEADS for high throughput ANALYTICAL CHEMISTRY TECHNIQUES.
A class of saturated compounds consisting of two rings only, having two or more atoms in common, containing at least one hetero atom, and that take the name of an open chain hydrocarbon containing the same total number of atoms. (From Riguady et al., Nomenclature of Organic Chemistry, 1979, p31)
The study, control, and application of the conduction of ELECTRICITY through gases or vacuum, or through semiconducting or conducting materials. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; FLUORESCENCE IMAGING; and MICROSCOPY.

Microbial desulfurization of organic sulfur compounds in petroleum. (1/1894)

Sulfur removal from petroleum is important from the standpoint of the global environment because the combustion of sulfur compounds leads to the production of sulfur oxides, which are the source of acid rain. As the regulations for sulfur in fuels become more stringent, the existing chemical desulfurizations are coming inadequate for the "deeper desulfurization" to produce lower-sulfur fuels without new and innovative processes. Biodesulfurization is rising as one of the candidates. Several microorganisms were found to desulfurize dibenzothiophene (DBT), a representative of the organic sulfur compounds in petroleum, forming a sulfur-free compound, 2-hydroxybiphenyl. They are promising as biocatalysts in the microbial desulfurization of petroleum because without assimilation of the carbon content, they remove only sulfur from the heterocyclic compounds which is refractory to conventional chemical desulfurization. Both enzymological and molecular genetic studies are now in progress for the purpose of obtaining improved desulfurization activity of organisms. The genes involved in the sulfur-specific DBT desulfurization were identified and the corresponding enzymes have been investigated. From the practical point of view, it has been proved that the microbial desulfurization proceeds in the presence of high concentrations of hydrocarbons, and more complicated DBT analogs are also desulfurized by the microorganisms. This review outlines the progress in the studies of the microbial desulfurization from the basic and practical point of view.  (+info)

5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. (2/1894)

We previously demonstrated a change in the receptors mediating 5-hydroxytryptamine (5-HT)-induced contraction in arteries of deoxycorticosterone acetate (DOCA)-salt-hypertensive rats. Specifically, contraction to 5-HT is mediated primarily by 5-HT2A receptors in arteries from normotensive sham rats and by both 5-HT2A and 5-HT2B receptors in arteries from hypertensive rats. We hypothesized that the 5-HT2B receptor may play a role in maintaining the high blood pressure of DOCA-salt-hypertensive rats, and herein we provide data connecting in vitro and in vivo findings. The endothelium-denuded isolated superior mesenteric artery of DOCA-salt rats displayed a marked increase in maximum contraction to the newly available 5-HT2B-receptor agonist BW-723C86 compared with that of arteries from sham rats, confirming that the 5-HT2B receptor plays a greater role in 5-HT-induced contraction in arteries from DOCA-salt rats. In chronically instrumented rats, the 5-HT2B-receptor antagonist LY-272015 (0.3, 1.0, and 3.0 mg/kg iv at 30-min intervals) was given cumulatively 1 time/wk during 4 wk of continued DOCA-salt treatment. LY-272015 did not reduce blood pressure of the sham-treated rats at any time or dose. However, LY-272015 (1.0 and 3. 0 mg/kg) significantly reduced mean blood pressure in a subgroup of week 3 (-20 mmHg) and week 4 DOCA-salt (-40 mmHg) rats that had extremely high blood pressure (mean arterial blood pressure approximately 200 mmHg). Blockade of 5-HT2B receptors by in vivo administration of LY-272015 (3.0 mg/kg) was verified by observing reduced 5-HT-induced contraction in rat stomach fundus, the tissue from which the 5-HT2B receptor was originally cloned. These data support the novel hypothesis that 5-HT2B-receptor expression is induced during the development of DOCA-salt hypertension and contributes to the maintenance of severe blood pressure elevations.  (+info)

Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. (3/1894)

HER2/neu, a Mr 185,000 tyrosine kinase receptor that is overexpressed in breast cancer, undergoes proteolytic cleavage of its extracellular domain (ECD). In contrast with other membrane-bound proteins, including growth factor receptors, that are cleaved by a common machinery system, we show that HER2 cleavage is a slow process and is not activated by protein kinase C. Pervanadate, a general inhibitor of protein-tyrosine phosphatases, induces a rapid and potent shedding of HER2 ECD. The shedding of HER2 ECD is inhibited by the broad-spectrum metalloprotease inhibitors EDTA, TAPI-2, and batimastat. The tissue inhibitor of metalloproteases-1; an inhibitor of matrix metalloproteases that does not inhibit cleavage by the general protein kinase C-dependent shedding machinery, also inhibited HER2 ECD shedding, whereas tissue inhibitor of metalloproteases-2 did not. These data suggest that HER2 cleavage is a process regulated by an as-yet-unidentified distinct protease.  (+info)

Phase I study of intrapleural batimastat (BB-94), a matrix metalloproteinase inhibitor, in the treatment of malignant pleural effusions. (4/1894)

Tumor cells and associated stromal cells secrete matrix metalloproteinases (MMPs), contributing to invasion, angiogenesis, and metastasis. Batimastat (BB-94) is a broad-spectrum MMP inhibitor that causes resolution of ascites and/or tumor growth delay in animal models of breast, ovarian, and colorectal cancer. We recruited 18 patients with cytologically positive malignant pleural effusions into a Phase I study of intrapleural BB-94. Three patients received single doses of BB-94 at each dose level: 15, 30, 60, 105, 135, and 300 mg/m2. Two patients were retreated with a second course at 60 and 105 mg/m2. BB-94 was detectable in plasma 1 h after intrapleural administration, and peak levels of 20-200 ng/ml occurred after 4 h to 1 week. BB-94 persisted in the plasma for up to 12 weeks, at levels exceeding the IC50s for target MMPs. Peak values were higher, and persistence in the plasma was longer after higher doses of BB-94. The treatment was well tolerated. Toxic effects included low-grade fever for 24-48 h (6 of 18 patients, 33%) and reversible asymptomatic elevation of liver enzymes (8 patients, 44%). Toxicity seemed unrelated to BB-94 dose or plasma levels. Sixteen patients evaluable for response required significantly fewer pleural aspirations in the 3 months after BB-94 compared with the 3 months before. Seven patients (44%) required no further pleural aspiration until death/last follow-up. After 1 month, patients treated with 60-300 mg/m2 BB-94 had significantly better dyspnea scores, indicating improved exercise tolerance, compared with baseline scores the day after BB-94. The maximum tolerated intrapleural dose remains to be defined, but it is clear that intrapleural BB-94 is well tolerated, with evidence of local activity.  (+info)

Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenan-airpouch inflammation. (5/1894)

1. Cyclo-oxygenase-2 (COX-2) is expressed at sites of inflammation and is believed to be the major source of inflammation-associated prostaglandin synthesis. Selective inhibition of COX-2 has been suggested to produce anti-inflammatory effects with reduced toxicity in the gastrointestinal tract. We examined the extent to which suppression of COX-2 led to inhibition of various components of inflammation in the carrageenan-airpouch model in the rat. 2. Indomethacin (> or =0.3 mg kg(-1)), nimesulide (> or =3 mg kg(-1)) and the selective COX-2 inhibitor, SC-58125 (> or =0.3 mg kg(-1)), significantly suppressed the production of prostaglandin E2 at the site of inflammation. At higher doses, indomethacin (> or =1 mg kg(-1)) and nimesulide (30 mg kg(-1)), but not SC-58125 (up to 10 mg kg(-1)), significantly inhibited COX-1 activity (as measured by whole blood thromboxane synthesis). 3. All three test drugs significantly reduced the volume of exudate in the airpouch, but only at doses greater than those required for substantial (>90%) suppression of COX-2 activity. Similarly, reduction of leukocyte infiltration was only observed with the doses of indomethacin and nimesulide that caused significant suppression of COX-1 activity. 4. SC-58125 did not significantly affect leukocyte infiltration into the airpouch at any dose tested (up to 10 mg kg(-1)). A second selective COX-2 inhibitor, Dup-697, was also found to suppress exudate PGE2 levels without significant effects on leukocyte infiltration. 5. These results indicate that selective inhibition of COX-2 results in profound suppression of PGE2 synthesis in the carrageenan-airpouch, but does not affect leukocyte infiltration. Exudate volume was only reduced with the highly selective COX-2 inhibitor when a dose far above that necessary for suppression of COX-2 activity was used. Inhibition of leukocyte infiltration was observed with indomethacin and nimesulide, but only at doses that inhibited both COX-1 and COX-2.  (+info)

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. (6/1894)

Solid tumors depend on angiogenesis for their growth. In a transgenic mouse model of pancreatic islet cell carcinogenesis (RIP1-Tag2), an angiogenic switch occurs in premalignant lesions, and angiogenesis persists during progression to expansive solid tumors and invasive carcinomas. RIP1-Tag2 mice were treated so as to compare the effects of four angiogenesis inhibitors at three distinct stages of disease progression. AGM-1470, angiostatin, BB-94, and endostatin each produced distinct efficacy profiles in trials aimed at preventing the angiogenic switch in premalignant lesions, intervening in the rapid expansion of small tumors, or inducing the regression of large end-stage cancers. Thus, anti-angiogenic drugs may prove most efficacious when they are targeted to specific stages of cancer.  (+info)

Marked suppression of T cells by a benzothiophene derivative in patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (7/1894)

In a search for new anti-autoimmune agents that selectively suppress activation of autoreactive T cells, one such agent, 5-methyl-3-(1-methylethoxy)benzo[b]thiophene-2-carboxamide (CI-959-A), was found to be effective. This compound, which is known to suppress tumor necrosis factor alpha (TNF-alpha)-induced CD54 expression, inhibited the primary proliferative response of the T cell to antigen (Ag)-presenting cells (APCs) including allogenic dendritic cells (DCs), autologous Epstein-Barr virus-infected B cells, and human T lymphotropic virus type I (HTLV-I)-infected T cells. Autoreactive T cells from patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) spontaneously proliferate in vitro, and their activation is reported to be associated with CD54 expression. The spontaneous proliferation of T cells from patients with HAM/TSP was entirely blocked by CI-959-A. However, in this study, the T-cell proliferation in 15 patients with HAM/TSP was found to depend more extensively on major histocompatibility complex (MHC) class II and CD86 than on CD54 Ags. Since most important APCs for the development of HAM/TSP are DCs and HTLV-I-infected T cells, the effect of CI-959-A on DC generation and on the expression of surface molecules on activated T cells is examined. CI-959-A suppressed recombinant granulocyte-macrophage colony stimulating factor (GM-CSF)- and recombinant interleukin-4-dependent differentiation of DCs from monocytes and inhibited the expression of CD54 and, more extensively, MHC class II and CD86 Ags. CI-959-A showed little toxicity toward lymphoma or HTLV-I-infected T-cell lines or toward monocytes and cultured DCs. These results suggest that CI-959-A might be a potent anti-HAM/TSP agent.  (+info)

Dorzolamide effect on ocular blood flow. (8/1894)

PURPOSE: To evaluate the effect of dorzolamide on ocular blood flow in normal and glaucomatous eyes. METHODS: Twenty-six eyes with documented open-angle glaucoma of 26 patients and 13 normal control eyes of 8 age-matched subjects were included in this study. All eyes underwent color Doppler imaging for measuring peak-systolic velocity, end-diastolic velocity, and resistance index in the ophthalmic and central retinal arteries and the maximal and minimal velocities in the central retinal vein. Eyes were grouped in control and initial and advanced glaucoma categories. Measurements were made in all groups before and after application of topical dorzolamide. Intragroup comparisons between baseline and dorzolamide conditions were made using paired Student's t-test. Intergroup comparisons under baseline conditions between normal and glaucomatous eyes were made by using the one-way ANOVA test. Statistical significance was set at P < 0.05. RESULTS: The peak-systolic velocity of the central retinal artery in glaucomatous eyes and the end-diastolic velocity of the ophthalmic and central retinal arteries in all groups were significantly higher after application of dorzolamide. The minimal velocity of the central retinal vein showed significantly higher values after dorzolamide, whereas the maximal velocity remained unchanged. The peak-systolic velocity of the ophthalmic artery in all groups and the peak-systolic velocity of the central retinal artery in normal eyes also remained unchanged. The resistance index was significantly lower in the ophthalmic and central retinal arteries in all groups after dorzolamide. The intraocular pressure was significantly reduced in all groups after dorzolamide. Under baseline conditions normal control eyes and glaucomatous eyes showed differences in various measurements. Peak-systolic velocity was significantly lower in glaucomatous eyes than in normal control eyes with the exception of the ophthalmic artery in the initial glaucoma group. End-diastolic velocity was lower in glaucomatous eyes than in control eyes in both arteries. Maximal and minimal velocities of the central retinal vein were lower in glaucomatous eyes than in normal control eyes. Resistance index was higher in glaucomatous eyes than in normal control eyes in the ophthalmic artery but not in the central retinal artery. CONCLUSIONS: Most hemodynamic parameters of intraocular and periocular vessels improve after application of topical dorzolamide in both normal control and glaucomatous eyes. Dorzolamide should be regarded as a useful drug for treatment of glaucoma not only because it reduces intraocular pressure but also because it improves the ocular blood supply.  (+info)

Show more ,Combretastatin A-4 and isocombretastatin A-4 derivatives having thiophenes or benzo[b]thiophenes instead of the B ring were prepared and evaluated for their in cellulo tubulin polymerization inhibition (TPI) and antiproliferative activities. The presence of the benzo[b]thiophene ring proved to have a crucial effect as most of the thiophene derivatives, except those having one methoxy group, were inactive to inhibit tubulin polymerization into microtubules. The influence of the attachment position was also studied: benzo[b]thiophenes having iso or cis 3,4,5-trimethoxystyrenes at position 2 were 12-30-fold more active than the 3-regioisomers for the TPI activity. Some of the novel designed compounds exhibited interesting anti-proliferative effects on two different cell lines.Show less , ...
Abstract:. Ask for Free Sample @ WMR- https://westernmarketresearch.com/sample-report/1144642/Europe Benzo[b]thiophene-2-carboxaldehyd#sample. The Europe Benzo[b]thiophene-2-carboxaldehyde market size is $XX million USD in 2018 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million USD by the end of 2024 with a CAGR of XX% from 2019 to 2024.. Ask for Free Sample-Inquiry and Discount @WMR- https://westernmarketresearch.com/market-report/1144642/Europe Benzo[b]thiophene-2-carboxaldehyd#inquiry. This report is an essential reference for who looks for detailed information on Europe Benzo[b]thiophene-2-carboxaldehyde market. The report covers data on Europe markets including historical and future trends for supply, market size, prices, trading, competition and value chain as well as Europe major vendors°Ø information. In addition to the data part, the report also provides overview of Benzo[b]thiophene-2-carboxaldehyde market, including classification, application, manufacturing ...
Thiophene is a maillard product At room temperature, thiophene is a colorless liquid with a mildly pleasant odor reminiscent of benzene, with which thiophene shares some similarities. The high reactivity of thiophene toward sulfonation is the basis for the separation of thiophene from benzene, which are difficult to separate by distillation due to their similar boiling points (4 C difference at ambient pressure). Like benzene, thiophene forms an azeotrope with water. Not only is thiophene reactive toward electrophiles, it is also readily lithiated with butyl lithium to give 2-lithiothiophene, which is a precursor to a variety of derivatives, including ...
3-Chlorothieno[2,3-b]thiophene-2-carboxylic acid, 97%, Maybridge Amber Glass Bottle; 1g 3-Chlorothieno[2,3-b]thiophene-2-carboxylic acid, 97%, Maybridge Chlorot to...
Get Thiophene Derivatives at Spectrum Chemical. SpectrumChemical.com carries a full line of fine chemicals, lab appliances and lab supplies. Spectrum Chemical offers fine chemicals in lab and production sizes.
Leishmania major (L. major) is a protozoan parasite that causes cutaneous leishmaniasis. About 12 million people are currently infected with an annual incidence of 1.3 million cases. The purpose of this study was to synthesize a small library of novel thiophene derivatives, and evaluate its parasitic activity, and potential mechanism of action (MOA). We developed a structure-activity relationship (SAR) study of the thiophene molecule 5A. Overall, eight thiophene derivatives of 5A were synthesized and purified by silica gel column chromatography. Of these eight analogs, the molecule 5D showed the highest in vitro activity against Leishmania major promastigotes (EC50 0.09 ± 0.02 µM), with an inhibition of the proliferation of intracellular amastigotes higher than 75% at only 0.63 µM and an excellent selective index. Moreover, the effect of 5D on L. major promastigotes was associated with generation of reactive oxygen species (ROS), and in silico docking studies suggested that 5D may play a role in
The preparation of a new poly(thiophene) with pendant N-hydroxysuccinimide ester groups and its application to immobilization of biomolecules are reported. A thiophene derivative of N-hydroxysuccinimide ester was polymerized with FeCl3 in chloroform and the resulting poly(thiophene) was characterized by nuclear magnetic resonance (NMR), Fourier transform infrared (FT-IR), and gel permeation chromatography (GPC). This polymer reacts with amine-bearing molecules to yield new poly(thiophene) derivatives and the specific interactions at the side groups could be detected. Thus, a self-assembled monolayer (SAM) using the polymer was formed on a gold-coated quartz cell and anti-C-reactive protein (anti-CRP) was immobilized. The binding behavior of CRP on the surface was monitored by use of a surface plasmon resonance (SPR) sensor system. © 2008 Elsevier B.V. All rights reserved. ...
According to the available literature, up to present date, only one sulfilimine derivative of benzo[b]thiophene is reported and several sulfilimine and sulfoximine derivatives of monocyclic thiophene. Guided by this fact, we have prepared the reported sulfilimine and new sulfoximine derivative of benzo[b]thiophene that was previously unknown. The known synthesis of sulfilimine N- [1λ4-benzo[b]thiophenylidene]-4-methylbenzenesulfonamide (15) was followed in order to oxidise it and to obtain its sulfoximine. After few attempted oxidations, as well as preparations of other analogues of the aforementioned sulfilimine, we have successfully prepared sulfoximine 4-methyl-N- [1-oxo-1H-1λ6benzo[b]thiophen-1-ylidene]benzenesulfonamide by oxidation with H2O2-P2O5 reagent. Sulfoximine 17 is in fact sulfoximine derivative of benzo[b]thiophene. The comparison between the IR spectrum, 1H and 13C NMR spectra of sulfilimine 15 and sulfoximine 17 confirmed this is a new compound with the proposed structure ...
2-(2-Methoxyphenyl)benzo[b]thiophene | C15H12OS | CID 4137516 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Prothrombin time (PT) is a global clotting test assessing the extrinsic pathway of the blood coagulation cascade. The test is sensitive for deficiencies of Factors II, V, VII, and X, with sensitivity being best for Factors V, VII, and X and less pronounced for Factor II. The initial read-out of PT is in seconds. The PT slope describes the linear increase of PT for one unit increase in concentration, thus the unit of PT slope is s*(µg/L)^-1. The final population PK/PD model included a fixed slope that was fitted to the data of the 19 patients that were eligible for evaluation. The estimated mean value (fixed/ the same for all patients in this study) is presented for PT slope ...
Prothrombin time (PT) is a global clotting test assessing the extrinsic pathway of the blood coagulation cascade. The test is sensitive for deficiencies of Factors II, V, VII, and X, with sensitivity being best for Factors V, VII, and X and less pronounced for Factor II. The initial read-out of PT is in seconds. The PT slope describes the linear increase of PT for one unit increase in concentration, thus the unit of PT slope is s*(µg/L)^-1. The final population PK/PD model included a fixed slope that was fitted to the data of the 19 patients that were eligible for evaluation. The estimated mean value (fixed/ the same for all patients in this study) is presented for PT slope ...
TY - JOUR. T1 - d-orbital participation in bonding in thiophene. T2 - Comparison of CNDO/2 and ab initio results. AU - Náray-Szabó, G.. AU - Peterson, M. R.. PY - 1981/11. Y1 - 1981/11. N2 - We have compared CNDO/2 and ab initio STO-3G calculations for furan and thiophene with and without the inclusion of 3d-orbitals on oxygen and on sulphur. Comparison of localized molecular orbitals indicates that d-orbital participation is over-estimated within the CNDO/2 approximation, although trends are reflected correctly. Enhanced aromaticity of thiophene compared to furan is primarily due to the delocalization of C2C3 π-bonds to the vacant d-orbitals of sulphur. On the other hand, d-orbitals are unimportant in describing σ-bonds. Energies of canonical molecular orbitals, as obtained with the CNDO/2 and ab initio STO-3G* methods and divided into separate σ and π groups, run parallel with each other within both groups.. AB - We have compared CNDO/2 and ab initio STO-3G calculations for furan and ...
APPLIED ORGANOMETALLIC CHEMISTRY Appl. Organometal. Chem. 2007; 21: 1041-1053 Published online 8 October 2007 in Wiley InterScience (www.interscience.wiley.com) DOI:10.1002/aoc.1329 Materials, Nanoscience and Catalysis Synthesis and reactivity of thiophene palladium and thiophene dipalladium complexes with unsaturated molecules Abdel-Sattar S. Hamad Elgazwy* Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt Received 9 July 2007; Revised 16 August 2007; Accepted 16 August 2007 • Reactions of 2,5-dibromothiophene, 1, with [Pd2 (dba)3 ] dba [Pd(dba)2 ; dba = dibenzylideneacetone] in the presence of N-donor ligands such as 2,2 -bipyridine (bpy) and 4,4 -di-tert-butyl-2,2 -bipyridine (dtbbpy) give arylpalladium complexes of cis-[2-(5-BrC4 H2 S)PdBrL2 ], 2a, b [L2 = bpy (2a), L2 = dtbbpy (2b)], and cis-cis-L2 PdBr[2,5-(C4 H2 S-)PdBr(L2 )], 3a, b [L2 = bpy (3a), L2 = dtbbpy (3b)]. Treatment of cis complexes 2a, b and 3a, b with CO causes the insertion of ...
Thiophene functionalized polystyrene samples (TFPS) were synthesized by atom transfer radical polymerization (ATRP) of styrene, followed by Suzuki coupling with 3-thiophene (Th) boronic acid. Conducting graft polymer of TFPS with thiophene was achieved at 1.5 V in tetrabutylammonium tetrafluoroborate/dichloromethane (TBAFB/DM) by electrochemical methods. Spectroelectrochemical analysis of the resulting copolymers [P(TFPS-co-Th)] reflected electronic transitions at 449, 721 and 880 nm, revealing pi - pi* transition, polaron and bipolaron band formation, respectively. We also successfully established the utilization of dual type complementary colored polymer electrochromic devices using P(TFPS-co-Th)/poly(3,4-ethylenedioxythiophene (PEDOT) in sandwich configuration. The switching ability, stability and optical memory of the electrochromic device were investigated by UV-visible spectrophotometry and cyclic voltammetry. Device switches between brown and blue color with a switching time of 1.3 s were ...
TY - GEN. T1 - Properties of electropolymerized thiophene film 3-substituted with imidazolyl group. AU - Kobayashi, Tomohiro. AU - Oyaizu, Kenichi. AU - Yuasa, Makoto. PY - 2005. Y1 - 2005. N2 - Electropolymerizable iron porphyrins have been found to be effective as an electrocatalyst for the detection of a superoxide anion radical. Thiophene 3-substituted with an imidazolyl group was synthesized and electropolymerized. Coordination of the imidazolyl group to various iron complexes provided a novel electrocatalyst for the detection of superoxide. Properties of the electrochemical sensors were evaluated.. AB - Electropolymerizable iron porphyrins have been found to be effective as an electrocatalyst for the detection of a superoxide anion radical. Thiophene 3-substituted with an imidazolyl group was synthesized and electropolymerized. Coordination of the imidazolyl group to various iron complexes provided a novel electrocatalyst for the detection of superoxide. Properties of the electrochemical ...
5-{[Bis-(1-methyl-2-oxo-ethyl)-amino]-methyl}-thieno[2,3-b]thiophene-2-sulfonic acid amide; hydrochloride | C13H16N2O4S3 | CID 44296814 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Learn more about Ethyl-2-[(cyanoacetyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate. We enable science by offering product choice, services, process excellence and our people make it happen.
As podiatrists, we are aware of the complications of PAD, with over 8.5 million people within the United States afflicted by this disease.32 With a significant number of these individuals being asymptomatic, awareness of this disease is paramount to all lower-extremity physicians. PAD is often diagnosed only when it reaches a symptomatic or critical stage, at which point treatment tends to focus on endovascular or surgical procedures.33 While these techniques have evolved and innovative treatments continue to be developed, these options do not address the underlying pathophysiologic development of PAD. Atherosclerotic disease includes PAD, CAD, and cerebrovascular disease (CVD). These disease states have significant overlap, as evidenced in the REACH registry where 3 out of 5 patients with PAD also had CAD and/or CVD. REACH was a large, global, observational registry of ~68,000 patients in 44 countries who were at high risk of atherothrombosis.34 Nearly 1 in 5 patients from the REACH registry ...
The composition of non-methane organic volatile compounds (VOCs) determined in 139 thermal gas discharges from 18 different geothermal and volcanic systems in Italy and Latin America, consists of C2-C20 species pertaining to the alkanes, alkenes, aromatics and O-, S- and N-bearing classes of compounds. Thiophenes and mono-aromatics, especially the methylated species, are strongly enriched in fluids emissions related to hydrothermal systems. Addition of hydrogen sulphide to dienes and electrophilic methylation involving halogenated radicals may be invoked for the formation of these species. On the contrary, the formation of furans, with the only exception of C4H8O, seems to be favoured at oxidizing conditions and relatively high temperatures, although mechanisms similar to those hypothesized for the production of thiophenes can be suggested. Such thermodynamic features are typical of fluid reservoirs feeding high-temperature thermal discharges of volcanoes characterised by strong degassing activity,
In this work, we report on the synthesis, characterization, and photovoltaic properties of two new N-annulated PDI derivatives connected with one (M1) or two (M2) thiophene bridging units and directly compare to a twisted PDI dimer with no thiophene units (tPDI-Hex). Compounds M1 and M2 were synthesized usin CSC100: Celebrating Canadian Chemistry
D4735 - 15 Standard Test Method for Determination of Trace Thiophene in Refined Benzene by Gas Chromatography , benzene, capillary column, flame photometric detector, gas chromatography, pulsed flame photometric detector, split/splitless injector, thiophene,,
We examined the thermal crystallization of deposited films made of 2,5-bis(4-biphenylyl)thiophene (BP1T) and 1,4-bis(5-phenylthiophen-2-yl)benzene (AC5), which are thiophene/phenylene co-oligomers (TPCOs). The deposited films of both BP1T and AC5 showed a microcrystalline phase, and initial microcrystals got larger 10 - 100 times with thermal treatment. Furthermore, we measured the optical properties of microcrystals of BP1T and AC5. At the energy density below the spontaneous amplified emission threshold, it was found that there was a big fluorescent difference between femtosecond laser irradiation and continuous lamp irradiation ...
Schopf and G. ~L--C. ~---SiMe3 Spiro-fused thiophene trimer (a) and spiro-fused thiophene heptamer (see also Sect. 1) (b) [28, 29] Polythiophenes ElectricallyConductive Polymers S ~ ~ 31 S S S n S -- -- n n Polymers of dithieno[3,4-b;3,4-d]thiophene [4, 3~32] Poly(phenanthro[9,10-c]thiophene-2,11-diylidyne) (see also Sect. 3) [-33] Poly(naptho [2,3-c]thiophene-2,9-diyl-2,2-bithiophene-5,5-diyl) [-34] Poly(thieno [3,4-c] thiophene-2,6-diylidynemet hylidene-2,2-bithiophene- 5,5diylmethylidene) [-35] R R Polymers of 4,4-dialkylcyclopenta[-2,1-b;3,4-b]bithiophene n = 1, 3, 4, 6, 8, 16) [,11, 36, 37] s} (o) (R=CnH2n+I, 5 (b) Polymers of 4-(1,3-dithiol-2-ylidene)-4H-cyclopenta[2,1-b;3,4-b]bithiophene (a) and of 7-(1,3-dithiol-2-ylidene)-TH-cyclopenta[1,2-b;3,4-b]bithiophene (b) [38] 32 G. Schopf and G. KoBmehl Table 6. Continued Key words Section in this review Ref. 7 524, 681 577 70 146, 148 615 524 340, 495 333 Contin. Polythiophenes 21 Electrically Conductive Polymers Table 6. Continued ...
EINSTEIN PE: Oral Rivaroxaban Alone for Symptomatic Pulmonary Embolism. -Trial Overview by Dr. Harry Roger Buller (ACC 2012). MAGELLAN: Rivaroxaban Compared with Enoxaparin for the Prevention of Venous Thromboembolism in Acutely Ill Medical Patients. -Trial Overview by Dr. Alexander Cohen (ACC 2011). ROCKET-AF: Stroke Prevention Using the Oral Direct Factor Xa Inhibitor Rivaroxaban Compared with Warfarin in Patients with Nonvalvular Atrial Fibrillation. -Trial Overview by Dr. Kenneth Mahaffey and Dr. Keith Fox (AHA 2010). ...
Several diarylamines la-f and 2 were prepared using palladium-catalyzed C-N coupling of electron deficient or rich benzo[b]thienylbromides with aromatic amines. Using 2-aminopyridine a one pot C-N coupling and intermolecular cyclization involving the nitrogen of the pyridine, with lost of ethanol, occurred giving compound 3 ...
Photoresponsive molecules have a broad range of potential applications, for example in optical, energy, and biomedical technologies. Fluorophores and second order nonlinear optical (NLO) chromophores are photoresponsive molecules used as signaling materials and frequency doublers or electro-optical modulators, respectively. The research presented here describes the synthesis, characterization, and potential applications of a group of highly fluorescent molecules and NLO chromophores containing benzene, imidazole and thiophene rings. Methyl, methoxy, and dimethylamino groups were used as electron donor groups while formyl and nitro groups were used as electron acceptors. The fluorescence properties of a series of dyes containing donor groups and a formyl group attached to a thiophenyl ring were investigated. X-ray structural determination revealed a steric crowding, which causes a molecular twist in the ground state. The fluorescence quantum yield for these fluorophores was found in the range of0.004-1.0
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
136434-34-9 - BFFSMCNJSOPUAY-LMOVPXPDSA-N - Duloxetine hydrochloride [USAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Cymbalta with NDC 0002-3235 is a a human prescription drug product labeled by Eli Lilly And Company. The generic name of Cymbalta is duloxetine hydrochloride.
NSC 652287 is a representative of a novel class of thiophene derivatives discovered in the NCI Anticancer Drug Screen for their activity against the subpanel of cell lines derived from renal cancer, a disease for which present chemotherapy has limited activity. The present study shows that thiophene NSC 652287 is a potent inducer of apoptosis at submicromolar concentrations. Apoptosis was associated with p53 elevation and decrease of p21WAF1 protein levels in A498 cells. By contrast, lower NSC 652287 concentrations induced elevation of both p53 and p21WAF1 and cell cycle arrest (Fig. 3 and Table 2). A decrease of p21WAF1 in spite of p53 elevation at NSC 652287 concentrations that induced apoptosis was probably due to p21WAF1 degradation during apoptosis. p21WAF1 is indeed a substrate for caspases (Gervais et al., 1998).. Although A498 cells have wild-type p53 and are very sensitive to NSC 652287, two of the most resistant kidney cell lines of the NCI Anticancer Drug Screen, ACHN and UO-31, also ...
Abstract A series of 3-[5-nitro(furan/thiophene)-2-yl]-1-aryl-3-(5-aryl-1,3,4-oxadiazol-2-ylthio)prop-2-en-1-one derivatives was synthesized and studied with the aim of developing dual inhibitors of...
TY - JOUR. T1 - Regioselective synthesis of thiophene fused sultam derivatives via iodocyclization approach and their application towards triazole linker. AU - Barange, Deepak Kumar. AU - Kavala, Veerababurao. AU - Kuo, Chun Wei. AU - Wang, Cheng Chuan. AU - Rajawinslin, R. R.. AU - Donala, Janreddy. AU - Yao, Ching Fa. PY - 2014/10/14. Y1 - 2014/10/14. N2 - An efficient regioselective synthesis of 4-iodo-2,3-disubstituted-2H-thieno[3,2-e][1,2]thiazine-1,1-dioxide derivatives via iodocyclization approach using iodine under mild reaction condition described herein. This coupling-iodocyclization strategy tolerated a variety of functional groups such as alkyl, cycloalkyl, phenyl producing the six-membered heterocyclic ring selectively. The resulting 4-iodo-2,3-disubstituted-2H-thieno[3,2-e][1,2]thiazine-1,1-dioxide was coupled with a variety of boronic acids (Suzuki coupling) and activated alkenes (Heck coupling). The iodo group was utilized for Sonogashira coupling followed by efficient ...
N-Methyl-N-nitrosotoluene-4-sulphonamide, find complete details about N-Methyl-N-nitrosotoluene-4-sulphonamide, Heterocyclic compound, Thiophene compounds, Aromatics - Baoji GuoKang Bio-Technology Co., Ltd.
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for (1E)-?1,1(3H,3H)-Bi[benzo[c]thiophene]-3,3-dione (CAS No. 23667-32-5)
Provide fine chemicals, building blocks and pharmaceutical intermediates. PI-41981 3,4-(2,2-Dimethylpropylenedioxy)thiophene (255901-50-9) Synonym: 3,3-Dimethyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine Molecular Formula: C9H12O2S Weight: 184.25 CAS No: 255901-50-9 Appearance: Purity:95.0% FM Point:42.0 to 46.0 deg-C Order online from laboratory chemical supplier and distributor.
N-cyclopropylmethyl-7-(1-hydroxy-1-methyl-3-(2-thiophene)propyl)-6,14-endoethanotetrahydrooripavine: has analgesic activity; structure in first source
Thiophene,3-bromo-4-ethoxy-(9ci)/ACM425426864 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
VALIDATION OF A METHOD FOR THE ANALYSIS OF 2-FURFURYLTHIOL, THIOPHENE AND DIMETHYL DISULFIDE BY GAS CHROMATOGRAPHY COUPLED WITH MASS SPECTROMETRY (GC-QMS) UEKANE, T.M.1*, ROCHA-LEÃO, M.H.M.2, REZENDE, C.M.1 1 Universidade Federal do Rio de Janeiro, Instituto de Química, Cidade Universitária, CT, Bloco A, CEP 21941-909, Rio de Janeiro - RJ, Brazil. 2 Universidade Federal do Rio…
The electronic and geometric structures of poly [3-(4-octylphenyl)thiophene] have been studied by X-ray and ultraviolet photoelectron spectroscopy (XPS and UPS, respectively). Thermochromic effects, and new charge induced states generated by potassium doping, have been observed by direct UPS measurements. The experimental results are in very good agreement with the results of theoretical quantum chemical calculations performed with the Austin Model 1 semi-empirical model and the valence-effective Hamiltonian pseudo-potential model.. ...
Infrared laser multiple photon excitation/dissociation of Thiophene (Th) was studied as a function of Th pressure, laser pulse energy, pulse duration and added buffer gas. While the excitation...
Buy high quality 2-Amino-2-(2-chlorophenyl)acetic acid 88744-36-9,141196-64-7 from Carbosynth, your source for Carbohydrates, Nucleosides and Fine Chemicals.
Page contains details about poly[4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b;4,5-b]dithiophene-2,6-diyl-alt-(4-(2-ethylhexyl)-3-fluorothieno[3,4-b]-thiophene-)-2-carboxylate-2-6-diyl)]:poly[[N,N`-bis(2-octyldodecyl)-napthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,5`-(2,2`-bithiophene)]-based polymer solar cell . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
2-(1h-pyrrol-1-yl)thiophene-3-carboxylic acid/ACM79242765 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Alfa Aesar™ Potassium thiophene-3-trifluoroborate, 97% 250mg Alfa Aesar™ Potassium thiophene-3-trifluoroborate, 97% Inorganic Potassium Compounds
Acid dissociation constants, pKa, of 2-pyrrolaldehyde phenylsulphonyl hydrazone, 1, and 2-thiophenealdehyde phenylsulphonyl hydrazone, 2, have been determined spectrophotometrically in ethanol-water media of various compositions over the temperature range 25℃ - 45℃. The obtained results were used in the calculation of the enthalpy, △H°, and the entropy, △S°, of the ionization processes. The slight variations observed in the pKa values of the thiophene compound compared to the pyrrol analogue revealed that neither of the two hetero atoms in the pyrrol or thiophene rings, of the two compounds, is involved in a hydrogen bond chelation. This conclusion was also confirmed through measurements of the dipole moment, IR and NMR spectra.
Duloxetine, pregabalin, and gabapentin offer similar efficacy for patients with diabetic peripheral neuropathic pain, according to a new report. Few direc
Read about the chemical and physical properties of 5-(2-Methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-thiophene-2-carboxylic acid [(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-amide. Get 5-(2-Methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-thiophene-2-carboxylic acid [(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-amide molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
In order to tune the optoelectronic and charge transfer properties of 4,6-di(thiophen-2-yl)pyrimidine (1), some new compounds were designed, i.e., 4,6-bis(benzo[$b$]thiophen-2-yl)pyrimidine (2), 4,6-bis(naphtho[2,3-b]thiophen-2-yl)pyrimidine (3), 4,6-bis(anthra[2,3-b]thiophen-2-yl)pyrimidine (4), 4,6-bis(tetraceno[2,3-$b$]thiophen-2-yl)pyrimidine (5) and 4,6-bis(pentaceno[2,3-$b$]thiophen-2-yl)pyrimidine (6). Compounds 2-6 were designed by assimilation of benzene, naphthalene, anthracene, tetracene and pentacene, respectively at both ends of compound 1. Integration of oligocene end cores reduces the energy gap resulting in a red shift in the absorption and fluorescence emission spectra. The legible intra-molecularcharge transfer is significant from electron-rich moieties to the electron-deficient core (pyrimidine). The elongation of $\pi$-conjugation led to escalate the electron affinity, lower the ionization potential and hole reorganization energy. The hole reorganization energies of compounds ...
Our results demonstrate that strontium ranelate has structure-modifying activity in patients with knee osteoarthritis, with significantly smaller degradations in JSW over the study (p,0.001 for 1 g/day and p=0.018 for 2 g/day vs placebo). There were fewer patients with radiographical and radioclinical progression of osteoarthritis in the treatment groups. Additionally to this structural effect, symptomatic improvement was observed, with a significant impact on WOMAC total score and pain subscore (p=0.045 and p=0.028, respectively), and a trend towards improvement in global knee pain (p=0.065) at 2 g/day, but not 1 g/day. The safety profile of strontium ranelate was satisfactory, in line with knowledge of this agent.20 ,21 There was a slight mean increase in creatine phosphokinase in the treated groups as previously described for strontium ranelate.20 Pooled analysis in osteoporotic patients treated with strontium ranelate showed that increases were mainly mild, transient and reversible22; they ...
center dot Rivaroxaban is an oral, direct Factor Xa inhibitor in advanced clinical development for the prevention and treatment of thromboembolic disorders.. center dot In single- and multiple-dose Phase I studies in White subjects, rivaroxaban was safe and demonstrated predictable, dose-dependent pharmacokinetics and pharmacodynamics.. WHAT THIS STUDY ADDS. center dot The Phase III programme with rivaroxaban is being conducted worldwide.. center dot Therefore, it is necessary to determine whether the pharmacokinetics, pharmacodynamics and tolerability of rivaroxaban are altered in patients of different ethnic origins.. center dot Dose-escalation studies were conducted to determine the safety, pharmacokinetics and pharmacodynamics of single and multiple doses of rivaroxaban in healthy Chinese subjects.. AIMS. To investigate the safety, pharmacokinetics and pharmacodynamics of rivaroxaban, an oral, direct Factor Xa (FXa) inhibitor, in healthy, male Chinese subjects.. METHODS. Two randomized, ...
A facile and convenient synthesis of some novel hydrazones, schiffs base and pyrazoles from thieno[2,3-b]thiophene derivatives 1 have been achieved in high yields assisted by microwave and classical methods. The structures of all the title compounds have been elucidated by elemental analysis, IR, MS, 1H-NMR and 13C-NMR. Generally, these findings represent a new class of sulfur and nitrogen moieties that should also be of interest as new materials.
Four nonvitamin K antagonist oral anticoagulants (NOACs) are approved for the prevention of stroke in patients with nonvalvular atrial fibrillation and for the treatment of venous thromboembolism. These include the direct thrombin inhibitor dabigatran and the direct factor Xa inhibitors rivaroxaban, apixaban, and edoxaban. Bleeding is a complication for all anticoagulants and concerns regarding bleeding risk and the suitability of effective reversal strategies may be a barrier to their prescription. Despite the reduced risk of bleeding compared with vitamin K antagonists, questions persist regarding the management of bleeding related to NOAC use. To date, although a number of assays are responsive to NOACs, no single routine laboratory test has been identified to accurately measure the clinical anticoagulation state of patients on NOACs or established as a reliable predictor of bleeding risk. In addition, the establishment of a reliable human bleeding model to test novel inhibitors of the coagulation
Four non-vitamin K antagonist oral anticoagulants (NOACs), including the direct thrombin inhibitor dabigatran and the direct factor Xa inhibitors rivaroxaban, apixaban, and edoxaban, are currently licensed as alternatives to heparins and vitamin K antagonists for the prevention and treatment of venous thromboembolism and for the prevention of stroke in patients with nonvalvular atrial fibrillation. Dabigatran is the only NOAC that inhibits thrombin; the others inhibit factor Xa. All of the NOACs are at least as effective as vitamin K antagonists for the prevention of stroke in patients with atrial fibrillation and for the treatment of venous thromboembolism, and they are associated with less life-threatening bleeding, in particular less intracranial hemorrhage.1,2 Nonetheless, serious bleeding can occur with NOACs. In addition, patients taking NOACs may sustain trauma and may require urgent surgery or interventions. Consequently, the availability of specific reversal agents for NOACs could ...
Acidic zeolites like H-Y, H-ZSM-5, H-MCM-22 and H-MOR zeolites were found to be the selective adsorbents for the removal of thiophene from toluene or n-heptane as solvent. The competitive adsorption of toluene is found to influence the adsorption capacity for thiophene and is more predominant when high-alumina zeolites are used as adsorbents. This behaviour is also reflected by the results of the adsorption of thiophene on H-ZSM-5 zeolites with varied nSi/nAl ratios (viz. 13, 19 and 36) from toluene and n-heptane as solvents, respectively. UV-Vis spectroscopic results show that the oligomerization of thiophene leads to the formation of dimers and trimers on these zeolites. The oligomerization in acid zeolites is regarded to be dependent on the geometry of the pore system of the zeolites. The sulphur-containing compounds with more than one ring viz. benzothiophene, which are also present in substantial amounts in certain hydrocarbon fractions, are not adsorbed on H-ZSM-5 zeolites. This is ...
TY - GEN. T1 - Electropolymerization of thiophene having porphyrin group and its application to superoxide sensor. AU - Hoshino, Manabu. AU - Murata, Hidenori. AU - Oyaizu, Kenichi. AU - Yuasa, Makoto. PY - 2006. Y1 - 2006. N2 - Iron 5-(3-thienyl)-10,15,20-triethylporphyrin was electropolymerized in supercritical carbon dioxide (scCO2) to yield the corresponding conductive polymer film. The film was analyzed by scanning electron microscopy, laser microscopy and AFM. It was revealed that the thiophene-porphyrin film synthesized in scCO2 was more dense and smoother than those synthesized in dichloromethane. The electrocatalyst was applied to a superoxide anion radical sensor, and its detection sensitivity was drastically increased.. AB - Iron 5-(3-thienyl)-10,15,20-triethylporphyrin was electropolymerized in supercritical carbon dioxide (scCO2) to yield the corresponding conductive polymer film. The film was analyzed by scanning electron microscopy, laser microscopy and AFM. It was revealed that ...
Advances in Heterocyclic Chemistry - 1st Edition - ISBN: 9780124201606, 9780124202092. Paal-Knorr Reaction in the Synthesis of Heterocyclic Compounds.. Thiophene and Its Derivatives, Part 2 (The Chemistry of ... Buy Thiophene and Its Derivatives, Part 2 (The Chemistry of Heterocyclic Compounds, Vol. 44) on Amazon.com ✓ FREE SHIPPING on qualified orders. Chemistry of Heterocyclic Compounds Profession. Heterocyclic compounds are presumably the largest class of organic compounds, obtaining great diversity in chemical and physical properties. Thus Chemistry of Heterocyclic Compounds - CRC Press Book Dec 22, 2014 This book discusses the structure, synthesis, and reactivity of heterocyclic compounds. It covers nomenclature, conformational aspects, Heterocyclic Chemistry - MSU Chemistry Devising a systematic nomenclature system for heterocyclic compounds presented a formidable challenge, which has not been uniformly concluded. Thiophene and Its Derivatives, Part 2 (The Chemistry of ... Buy Thiophene ...
The new fluorocarbon-functionalized polythiophenes, in particular, α,ω-diperfluorohexylsexithiophene DFH-6T (1) can be straightforwardly prepared in high yield and purified by gradient sublimation. Introduction of perfluorocarbon chains on the thiophene core affords enhanced thermal stability and volatility, and increased electron affinity versus the fluorine-free analog 2. Evaporated films of 1, for example, behave as n-type semiconductors, and can be used to fabricate thin film transistors with FET mobilities on the order of ˜0.01 cm2/Vs-some of the highest reported to date for n-type organic semiconductors.
The effect of oxidation on the energetics and structure of thiophene (Th) oligomers is studied with density functional theory at the B3PW91/6-311++G(d,p) level. Neutral n-Th oligomers (2 , n , 13) are gently curved planar chains. Ionization potential and electron affinity results show that n-Th oligomers are easier to be oxidized as their chain length increases. Oxidation states +2, +4, +6, and +8 are energetically stable in 12-Th. Upon oxidation the conjugated backbone of 12-Th switches from extended benzenoid phase to quinoid phase localized on groups of monomers regularly spaced along the chain. Oxidized states +2, +4, +6, and +8 of 12-Th display two +1e localized at the ends of their chains only because of the finite size of the chains. In 12-Th this end-effect extends over the two terminal monomers forming a positive-negative charge duet. This peculiar charge localization makes n-Th oligomers different from other conducting polymers with similar structure, such as polypyrrole. The spectrum ...
TY - JOUR. T1 - Photochemical generation of radical cations of dithienothiophenes, condensed thiophene trimers, studied by laser flash photolysis. AU - Fujitsuka, Mamoru. AU - Sato, Tadatake. AU - Shimidzu, Takeo. AU - Watanabe, Akira. AU - Ito, Osamu. PY - 1997/2/6. Y1 - 1997/2/6. N2 - Photoinduced electron-transfer reactions between dithienothiophene (DTT) and the electron acceptors, p-dinitrobenzene (DNB) and CCl4, have been investigated using nanosecond laser flash photolysis and time-resolved fluoresence spectroscopy. Generation of the radical cations of DTTs and radical anion of DNB in acetonitrile solution was confirmed by transient absorption spectra in the visible and near-IR regions. Observed transient absorption bands corresponded to those of radical ions generated by γ irradiation in a frozen matrix. Electron transfer occurred both from the singlet and triplet excited states of DTT to DNB at the diffusion-controlled rate, ∼1010 M-1 s-1. When CCl4 was used as an acceptor, electron ...
In the first part, the preparation and properties of chalcogen-containing vitamin E analogues are described. The sulfur compound 3,3,4,6,7-pentamethyl-2,3-dihydrobenzo[b]thiophene-5-ol was prepared by two different routes using ionic and radical chemistry. Interesting rearrangements were observed in the two synthetic pathways. A new methodology for the synthesis of dihydroselenophene and dihydrotellurophene derivatives is described. In the preparation of the vitamin E analogues 2,3-dihydrobenzo[b]selenophene-5-ol and 2,3-dihydrobenzo[b]tellurophene-5-ol a tellurium-mediated tandem SRN1/SHi sequence was suggested to be operative. 2,3-Dihydrobenzo[b]thiophene-5-ol and the vitamin E-like selenide 2-methyl-2-(4,8,12-trimethyl-tridecyl)-selenochroman-6-ol were prepared via intramolecular homolytic substitution at sulfur and selenium, respectively. The first rate constant for intramolecular homolytic substitution at tellurium is also reported (5x108 s-1 at 25 °C). The antioxidant profile for ...
Context: The clinical introduction of new oral anticoagulants (NOACs) has stimulated the development of tests to quantify the effects of these drugs and manage complications associated with their use. Until recently, the only treatment choices for the prevention of venous thromboembolism in orthopedic surgical patients, as well as for stroke and systemic embolism in patients with atrial fibrillation, were vitamin K antagonists, antiplatelet drugs, and unfractionated and low-molecular-weight heparins. With the approval of NOACs, treatment options and consequent diagnostic challenges have expanded. Objective: To study the utility of thromboelastography (TEG) in monitoring and differentiating between 2 currently approved classes of NOACs, direct thrombin inhibitors (dabigatran) and factor Xa inhibitors (rivaroxaban and apixaban). Design: Blood samples from healthy volunteers were spiked with each NOAC in both the presence and absence of ecarin, and the effects on TEG were evaluated. Results: Both ...
Context: The clinical introduction of new oral anticoagulants (NOACs) has stimulated the development of tests to quantify the effects of these drugs and manage complications associated with their use. Until recently, the only treatment choices for the prevention of venous thromboembolism in orthopedic surgical patients, as well as for stroke and systemic embolism in patients with atrial fibrillation, were vitamin K antagonists, antiplatelet drugs, and unfractionated and low-molecular-weight heparins. With the approval of NOACs, treatment options and consequent diagnostic challenges have expanded. Objective: To study the utility of thromboelastography (TEG) in monitoring and differentiating between 2 currently approved classes of NOACs, direct thrombin inhibitors (dabigatran) and factor Xa inhibitors (rivaroxaban and apixaban). Design: Blood samples from healthy volunteers were spiked with each NOAC in both the presence and absence of ecarin, and the effects on TEG were evaluated. Results: Both ...
4-(chloromethyl)-2-thiophen-2-yl-1,3-thiazole chemical properties, What are the chemical properties of 4-(chloromethyl)-2-thiophen-2-yl-1,3-thiazole 54679-16-2, What are the physical properties of 4-(chloromethyl)-2-thiophen-2-yl-1,3-thiazole ect.
2-(4-methoxyphenyl)-5-thiophen-2-ylthiophene 106925-79-5 NMR spectrum, 2-(4-methoxyphenyl)-5-thiophen-2-ylthiophene H-NMR spectral analysis, 2-(4-methoxyphenyl)-5-thiophen-2-ylthiophene C-NMR spectral analysis ect.
CAS NO:861965-63-1; Chemical name:thiophen-3-amine oxalate ; physical and chemical property of 861965-63-1, thiophen-3-amine oxalate is provided by ChemNet.com
Ansari F., P. Prayuenyong and I.E. Tothill. 2007. Biodesulfurization of dibenzothiophene by Shewanella putrefaciens. J. Bio.l Phys. Chem. 7:75-78. [Link]. Ardakani M.R., A. Aminsefat, B. Rasekh, F. Yazdiyan, B. Zargar, M. Zarei and H. Najafzadeh. 2010. Biodesulfurization of dibenzothiophene by a newly isolated Stenotrophomonas maltophila strain Kho1. WASJ. 10:272-2778. [Link]. Bahuguna A., M.K. Lily, A. Munjal, R.N. Singh and K. Dangwal. 2011. Desulfurization of dibenzothiophene (DBT) by a novel strain Lysinibacillus sphaericus DMT-7 isolated from diesel contaminated soil. J. Env. Sci. 23:975-982. [PubMED]. Berg J.M., J. Tymoczko and L. Stryer. 2007. Biochemistry. Freeman and company, New York.. Borgne S.L. and R. Quintero. 2003. Biotechnological processes for the refining of petroleum. Fuel process technol. 81:155-169. [Link]. Bustos-Jaimes I., G. Amador, G. Castorena and S. Le Borgne. 2003. Genotypic characterization of sulfur-oxidative desulfurizing bacterial strains isolated from Mexican ...
chemBlink provides information about CAS # 51527-19-6, 2-(5-Chloro-3-methylbenzo[b]thiophen-2-yl)acetic acid, molecular formula: C11H9ClO2S.
BACKGROUND AND OBJECTIVES: Strontium ranelate is a medication indicated for the treatment of osteoporosis that presents concomitant anti-resorptive and osteoanabolic dual biological activity. However, the effects of strontium ranelate on alveolar bone have been poorly explored. Furthermore, to date, there are no data on the effects of this medication on alveolar bone loss (BL) during conditions of estrogen deficiency. Therefore, the aim of this study was to evaluate the effects of strontium ranelate on ligature-induced periodontitis in estrogen-deficient and estrogen-sufficient rats. METHODS: Ninety-six rats were assigned to one of the following groups: sham-surgery + water (estrogen-sufficient; n = 24); ovariectomy + water (estrogen-deficient; n = 24), sham-surgery + strontium ranelate (ranelate/estrogen-sufficient; n = 24) and; ovariectomy + strontium ranelate (ranelate/estrogen-deficient; n = 24). The rats received strontium ranelate or water from the 14th day after ovariectomy until the end ...
TY - GEN. T1 - Selectivity of modified CeO2-based adsorbents for adsorptive desulfurization of hydrocarbon fuels. AU - Watanabe, Shingo. AU - Xiaoliang, Ma. AU - Song, Chunshan. PY - 2006/12/1. Y1 - 2006/12/1. N2 - Adsorptive desulfurization of a model fuel over CeO2-based adsorbents was conducted in a flowing adsorption system at 25 oC under ambient pressure without using H2 gas in order to evaluate the desulfurization performance of the adsorbent for producing ultra-low-sulfur fuel. For adsorption test, the capacity and selectivity of CeO2-based adsorbents for various sulfur compounds and the co-existing olefin and aromatic compound were used. Doping Ti and W into CeO2 significantly improved the sulfur removing capacity. The breakthrough sequence of the compounds over the CeO2-based adsorbents was, 1-C8 olefin °Ö toluene , thiophene , benzothiophene , 2-methyl benzothiophene , tetrahydrothiophene. By comparison of selectivity study and computational analysis, it was found that the electron ...
Duloxetine - Wikipedia, the free encyclopedia - Duloxetine (Cymbalta, and generics) is a serotonin-norepinephrine reuptake inhibitor (SNRI) manufactured and marketed by Eli Lilly. It is prescribed for major ……. I quit cymbalta 60 mg cold turkey Feb 27th 2011. Am I over … - I have been weaning myself off Cymbalta 60 mg. I refilled the last 30 day dose on January 24th 2011. Since then I have taken the pills every other day or every other ……. Cymbalta 60 mg hard gastro-resistant capsules , diagnosia.com - Cymbalta is a medicine that contains the active substance duloxetine. It is available as gastroresistant capsules (white and blue: 30 mg; green and blue: 60 mg)….. Drug - Dulane (30 mg) 30mg (Duloxetine) Price List - Drug information on brand Dulane (30 mg) 30mg (Duloxetine). It is manufactured by Sun Pharmaceutical Industries Ltd.. Find out its price,dose and the nearest pharmacy ……. Cymbalta Prescribing Information - 1 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not ...
Diabetes mellitus (DM) has been a significant public health problem for many years. However, the number of cases is continuing to grow at such an alarming rate that some have suggested we are facing or are already experiencing a diabetes epidemic.
Because of the prevalence of overweight (BMI 25-29.9) and obesity (30-39.9) in the United States, the incidence of diabetes is increasing.1 By the year 2010, the World Health Organization (WHO) estimates that there will be 220 million people with this disease worldwide.2 These statistics demonstrate the need to educate the physician not only about
Read about the chemical and physical properties of (4-Hydroxy-3,5-bis-pyrrolidin-1-ylmethyl-phenyl)-acetic acid thiophen-2-ylmethyl ester. Get (4-Hydroxy-3,5-bis-pyrrolidin-1-ylmethyl-phenyl)-acetic acid thiophen-2-ylmethyl ester molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
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Rivaroxaban is an oral, direct Factor Xa inhibitor approved in the European Union and several other countries for the prevention of venous thromboembolism in adult patients undergoing elective hip or knee replacement surgery and is in advanced clinical development for the treatment of thromboembolic disorders. Its mechanism of action is antithrombin independent and differs from that of other anticoagulants, such as warfarin (a vitamin K antagonist), enoxaparin (an indirect thrombin/Factor Xa inhibitor) and dabigatran (a direct thrombin inhibitor). A blood coagulation computer model has been developed, based on several published models and preclinical and clinical data. Unlike previous models, the current model takes into account both the intrinsic and extrinsic pathways of the coagulation cascade, and possesses some unique features, including a blood flow component and a portfolio of drug action mechanisms. This study aimed to use the model to compare the mechanism of action of rivaroxaban with that of
Previously, we reported that(R)−(−)−1−(benzo[b]thiophen−5−yl)−2−[2−(N, N−diethylamino)ethoxy]ethanol hydrochloride(T−588), a novel putative cognitive enhancer, stimulated noradrenaline(NA)release from rat cerebral cortical slices.In this study, we investigated the effects of T−588 compared to other secretagogues on NA release from PC12 cells.Addition of as little as 10 μM T−588 stimulated [,SUP,3,/SUP,H]NA release in a dose−dependent and an extracellular Ca,SUP,2+,/SUP,−independent manner from PC12 cells.Ten micromolar ionomycin−, 300 μM adenosine−5′−O−(γ−thiotriphosphate)− and 10 μM forskolin−induced extracellular Ca,SUP,2+,/SUP,−dependent [,SUP,3,/SUP,H]−NA release was further enhanced by 30 μM T−588.Cytosolic synaptophysin and 25−kDa synaptosome−associated protein immunoreactivity was increased by addition of T−588 in a dose−dependent manner.Interestingly, increases in synaptic vesicle−related proteins triggered by T−588 had ...
Novel oral anticoagulants offer equivalent or improved therapeutic profiles compared with warfarin, with less risk of bleeding, no interactions with food, and no need for routine laboratory monitoring. Caution must be exercised in using these drugs in certain patient populations, for example, renal insufficiency, those receiving additional antithrombotic therapy, those with questionable compliance, children, and those with a high risk of gastrointestinal bleeding. One of the novel oral anticoagulants, rivaroxaban, is a direct Factor Xa inhibitor, used to reduce risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, deep vein thrombosis, and pulmonary embolism ...
Raltitrexed (Tomudex, TDX, ZD 1694) is an antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca. Used in treatment of colorectal cancer since 1998. It may also be used in the treatment of malignant mesothelioma. Raltitrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites, which inhibit one or more of three enzymes that use folate and derivatives as substrates: DHFR, GARFT and thymidylate synthase. Raltitrexed is fully active after polyglutamylation, which allows cellular retention of the drug. By inhibiting Thymidylate synthase (TS), thus formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells. Inhibition of L1210 cell growth in culture IC50 = 9 nM, is one of the strongest antimetabolites in use. Structure and phase I clinical trial of the ...
Results XAMOS enrolled 17,701 patients; the safety population included 17,413 patients, of whom 8778 received rivaroxaban and 8635 received SOC (81.7% low molecular weight heparin). Baseline patient demographics and use of cytochrome P450 (CYP) 3A4 inhibitors or inducers and platelet aggregation inhibitors (PAIs) before surgery were similar between groups; these drugs were used less frequently after surgery. There was a significant reduction in the incidence of symptomatic thromboembolic events in the rivaroxaban group compared with the SOC group, with numerically but not statistically higher incidence of major bleeding events. Concomitant use of PAIs was associated with higher incidences of symptomatic thromboembolic and any bleeding events compared with non-use in both the rivaroxaban and the SOC groups (Table).. ...
An international research team has found that the blood thinner rivaroxaban is as safe as aspirin, and more effective at preventing recurrence of life-threatening blood clots in the legs and lungs.. The large international study of 3,396 patients with venous thromboembolism in 31 countries, published the New England Journal of Medicine. shows that rivaroxaban is more effective than aspirin.. Not only that, but in testing two doses of rivaroxaban, we found that we have the option of lowering the daily dose for extended treatment, said Dr. Jeffrey Weitz, principal investigator of the study and professor of medicine and biochemistry and biomedical sciences at the Michael G. DeGroote School of Medicine at McMaster University. This will ease the long-term concerns of both patients and their doctors.. During the study from March 2014 to March 2016, patients received either a daily 20mg dose of rivaroxaban, a 10mg dose of rivaroxaban, or a 100 mg dose of aspirin. They took these medications for up ...
PRODUCT INFORMATION XARELTO (rivaroxaban) NAME OF THE MEDICINE Xarelto (rivaroxaban) is a selective, direct acting Factor Xa inhibitor. Rivaroxaban is 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-
Osteoporosis is often accompanied by sarcopenia. The effect of strontium ranelate (SR) on muscle tissue has not been investigated sufficiently. In
We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivative
The step that involves n-BuLi would best be avoided, and if a more direct route of arriving at the Suzuki coupling step could be discovered, that would take a potentially dangerous and difficult step out of the synthetic route. One possibility, involving NIS and an ionic liquid such as 1-Butyl-3-methylimidazolium tetrafluoroborate (which our lab doesnt have, but which is available from Aldrich in catalytic quality from $247/5g), is found below: [doi:10.1016/j.tetlet.2011.03.010 DOI] [dx.doi.org/10.1139/V09-125 Here] is another alternative, where the direct iodonation of arenes can be carried out using oxone and NaI. Whether or not this would work in my compound, given selectivity issues, is something that Ill have to investigate. This paper shows a method of direct halogenation of thiophenes. This uses [Bis(trifluoroacetoxy)iodo]benzene, which we dont have lying around, but which can be bought from Aldrich for $136/10g. The reactivity of thiophenes vs pyrimidines is something Ill have to ...
The step that involves n-BuLi would best be avoided, and if a more direct route of arriving at the Suzuki coupling step could be discovered, that would take a potentially dangerous and difficult step out of the synthetic route. One possibility, involving NIS and an ionic liquid such as 1-Butyl-3-methylimidazolium tetrafluoroborate (which our lab doesnt have, but which is available from Aldrich in catalytic quality from $247/5g), is found below: [doi:10.1016/j.tetlet.2011.03.010 DOI] [dx.doi.org/10.1139/V09-125 Here] is another alternative, where the direct iodonation of arenes can be carried out using oxone and NaI. Whether or not this would work in my compound, given selectivity issues, is something that Ill have to investigate. This paper shows a method of direct halogenation of thiophenes. This uses [Bis(trifluoroacetoxy)iodo]benzene, which we dont have lying around, but which can be bought from Aldrich for $136/10g. The reactivity of thiophenes vs pyrimidines is something Ill have to ...
In order of importance, they are: thieno(3,2-b)thiophene, thieno(2,3-b)thiophene, and thieno(3,4-b)thiophene. Other isomers ... Thieno[2,3-b]thiophene CAS RN 250-84-0 b.p. 102 °C at 16 mmHg colorless oil. Thieno[3,4-b]thiophene CAS RN 250-65-7 m.p. 7.0- ... Thieno[2,3-b]thiophene was the first member of the series to be isolated. It was obtained in very low yield upon heating citric ... 2λ4δ2-Thieno[3,4-c]thiophene CAS RN 24976-21-4 not isolated. Cava, Michael P.; Lakshmikantham, M. V. (1975). "Nonclassical ...
... and Complete Characterization of Thiophene S-Oxide Dimers and Evidence for Thiophene S-Oxide as an Intermediate in Thiophene ... "Evidence for thiophene-S-oxide as a primary reactive metabolite of thiophene in vivo: formation of a dihydrothiophene sulfoxide ... Thiopropamine is a stimulant drug which is an analogue of amphetamine where the phenyl ring has been replaced by thiophene. It ... Campaigne E, McCarthy WC (September 1954). "3-Substituted Thiophenes. VIII. 3-Thienylalkylamines". Journal of the American ...
In addition to benzo[b]thiophene, a second isomer is known: benzo[c]thiophene. Benzothiophene finds use in research as a ... thiophenes, and Thieno[3,2-b]thiophenes". Organic Letters. American Chemical Society (ACS). 13 (15): 4100-4103. doi:10.1021/ ... CS1 maint: discouraged parameter (link) Cava, Michael P.; Lakshmikantham, M. V. (1975). "Nonclassical Condensed Thiophenes". ... thiophenes". The Journal of Organic Chemistry. American Chemical Society (ACS). 76 (18): 7546-7550. doi:10.1021/jo201081v. ISSN ...
ThiophenesEdit. Thiophenes are a special class of sulfide-containing heterocyclic compounds. Because of their aromatic ... As a consequence, thiophene exhibits few properties expected for a sulfide - thiophene is non-nucleophilic at sulfur and, in ... Upon hydrogenation, thiophene gives tetrahydrothiophene, C4H8S, which indeed does behave as a typical sulfide. ...
Unlike 2-bromothiophene, the 3-bromo isomer cannot be prepared directly from thiophene. It can be prepared by debromination of ... 2-Bromothiophene Jonathan Swanston (2006). "Thiophene". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. ... 2,3,5-tribromothiophene, which is obtained by bromination of thiophene. ...
Unlike 3-bromothiophene, the 2-bromo isomer is prepared directly by partial bromination of thiophene. It is a precursor to ... The LD50 is low, 200 - 250 mg/kg (oral, rat). Jonathan Swanston (2006). "Thiophene". Ullmann's Encyclopedia of Industrial ...
It is the saturated analog of thiophene. It is a volatile, colorless liquid with an intensely unpleasant odor. It is also known ... Tetrahydrofuran Thiophene Armarego WF, Chai CL (2003). "Purification of Organic Chemicals". Purification of Laboratory ... "Thiophene". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a26_793.pub2. Uson R, ...
"Thiophene". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a26_793.pub2. Dieter ...
By synthesizing thiophene and selenophene analogues, it was found that there was a reduction in the optical band gap as a ... Compared to thiophenes, tellurophenes have been found to have lower optical band gaps, significantly lower LUMO levels, and ... MIDA-capped thiophene, selenophene, and tellurophenes were synthesized through Stille coupling. Crystal structures of DPT-MIDA ... By replacing the pinacolboronate esters with thiophenes, there was no luminescence, indicating that both Te(II) and BPin played ...
Liu, Y.; Ye, M.; Guo, H. Z.; Zhao, Y. Y.; Guo, D. A. (2002). "New thiophenes from Echinops grijisii". Journal of Asian Natural ... In the most common isomer of terthiophene, two thienyl groups are connected via their 2 positions to a central thiophene, also ... It is an oligomer of the heterocycle thiophene, a shorter oligomer is dithienyl, and the parent polymer is polythiophene. ...
It can be produced by Wolff-Kishner reduction of thiophene-2-carboxaldehyde. 3-Methylthiophene King, Wm. J.; Nord, F. F. (1949 ... "Thiophene Series. V. Wolff-Kishner Reductions". Journal of Organic Chemistry. 14: 638-42. doi:10.1021/jo01156a016.. ...
"Palladium-Catalyzed Multiple Arylation of Thiophenes". Journal of the American Chemical Society. 124 (19): 5286-5287. doi: ... multiple reactions including the amination of a wide range of aryl halides and triflates as well as the arylation of thiophenes ...
Urban, S.; Beiring, B.; Ortega, N.; Paul, D.; Glorius, F. (2012). "Asymmetric Hydrogenation of Thiophenes and Benzothiophenes ... The asymmetric hydrogenation of thiophenes and benzothiophenes No heterogeneous catalyst has been commercialized for asymmetric ... of compounds where sulfur is part of the initial unsaturated pi-bonding system so far appears to be limited to thiophenes and ...
Heinz, J.; Schulze-Makuch, D. (2020). "Thiophenes on Mars: biotic or abiotic origin?". Astrobiology. 20 (4): 552-561. Maus, D ...
Thiophene, a sulfur analog. Simple aromatic rings Varsol, a petroleum distillate with a boiling range of 150-200 °C. Frederick ...
Polymerization of thiophene can be effected by a solution of ferric chloride in acetonitrile. The kinetics of thiophene ... and urethanes Thiophenes with chiral substituents at the 3 position have been polymerized. Such chiral PTs in principle could ... SCE, whereas unsubstituted thiophene requires an additional 0.2 V. Steric hindrance resulting from branching at the α-carbon of ... Poly(3-(perfluorooctyl)thiophene)s is soluble in supercritical carbon dioxide Oligothiophenes capped at both ends with ...
With 1,4-diketones the reagent forms thiophenes. It is also used to deoxygenate sulfoxides. The use of P4S10 has been displaced ...
V. The desulfurization of thiophene". J. Am. Chem. Soc. 82: 4749-4750. doi:10.1021/ja01502a080. King, R. B. (1995). "Thirty ...
Thiophene analog of phencyclidine (TCP) 7473 1-[1-(2-thienyl)cyclohexyl]pyrrolidine (TCPy) ...
Thiophene-expanded guanosine analogues of Gemcitabine. Bioorg Med Chem Lett. 2015;25(19):4274‐4276. Babkov DA, Valuev-Elliston ... Chen, Zhe; Ku, Therese C.; Seley-Radtke, Katherine L. (2015). "Thiophene-expanded guanosine analogues of Gemcitabine". ...
1,4-Diketones are also precursor to furans and thiophenes. The condensation of 1,4-diketones (and related substrates) with ...
... has the ability to grow on substituted thiophenes. LPSN lpsn.dsmz.de Straininfo of Xanthobacter ... nov., an organism associated with Tagetes species and able to grow on substituted thiophenes". International Journal of ... nov., an organism associated with Tagetes species and able to grow on substituted thiophenes". International Journal of ... "Chemolithoautotrophy and mixotrophy in the thiophene-2-carboxylic acid-utilizing Xanthobacter tagetidis". Archives of ...
Oberdorf C, Schepmann D, Vela JM, Diaz JL, Holenz J, Wünsch B (Oct 2008). "Thiophene bioisosteres of spirocyclic sigma receptor ...
... which can be dehydrobrominated to thiophene-1,1-dioxide with silver carbonate. Thiophene-1,1-dioxide, a highly reactive species ... The synthesis of thiophene-1,1-dioxide". Journal of the American Chemical Society. 76 (7): 1932-1936. doi:10.1021/ja01636a058. ...
In contrast, thiophene engages in neither reaction. Dihydrothiophenes contribute to the aroma of the white truffle. The major ...
Sensitive to thiophene-2-carboxylic acid hydrazide.[citation needed] Initially (after 3-4 weeks), minute dull flakes, ...
Included are pyridine, thiophene, pyrrole, and furan. Another large class of heterocycles refers to those fused to benzene ... For example, the fused benzene derivatives of pyridine, thiophene, pyrrole, and furan are quinoline, benzothiophene, indole, ... Thienothiophene are the fusion of two thiophene rings. Phosphaphenalenes are a tricyclic phosphorus-containing heterocyclic ...
5-Disubstituted Thiophenes". Synthesis. 1982 (12): 1061-1062. doi:10.1055/s-1982-30065. "Document 32012R0872".. ...
Included are pyridine, thiophene, pyrrole, and furan. Another large class of heterocycles are fused to benzene rings, which for ... Thienothiophene are the fusion of two thiophene rings. Phosphaphenalenes are a tricyclic phosphorus-containing heterocyclic ... pyridine, thiophene, pyrrole, and furan are quinoline, benzothiophene, indole, and benzofuran, respectively. Fusion of two ... "Design and environmentally benign synthesis of novel thiophene appended pyrazole analogues as anti-inflammatory and radical ...
Fe3(CO)12 form "ferroles" upon reaction with heterocycles such as thiophenes. Fe3(CO)12 reacts with thiols and disulfides to ...
Measured and calculated properties of thiophenes are given. Chemical and spectroscopic techniques for analysis of thiophenes ... and uses of thiophenes are discussed in order to provide the setting within which analyses must be performed. ... Measured and calculated properties of thiophenes are given. Chemical and spectroscopic techniques for analysis of thiophenes ... The occurrence, toxicity, and uses of thiophenes are discussed in order to provide the setting within which analyses must be ...
Oxidation can occur both at sulfur, giving a thiophene S-oxide, as well as at the 2,3-double bond, giving the thiophene 2,3- ... Oxidation of thiophenes may be relevant to the metabolic activation of various thiophene-containing drugs, such as tienilic ... Thiophenes undergo hydrogenolysis to form hydrocarbons and hydrogen sulfide. Thus, thiophene itself is converted to butane and ... Desulfurization of thiophene with Raney nickel affords butane. When coupled with the easy 2,5-difunctionalization of thiophene ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Damste, J.S.S.; van Dalen, A.C.K.; de Leeuw, J.W.; Schenck, P.A., Identification of homologous series of alkylated thiophenes, ... Damste, J.S.S.; Kock-van Dalen, A.C.; de Leeuw, J.W.; Schenk, P.A., Identification of homologous series of alkylated thiophenes ... 5. Thiophene, furan, and benzene derivatives, Izv. Akad. Nauk SSSR Ser. Khim., 1978, 11, 2271-2274. [all data] ... formyl and acetyl groups on retention of substituted furans and thiophenes in capillary GC, Chromatographia, 1992, 34, 9/10, ...
Benzo[c]thiophene is an organic compound with the chemical formula C8H6S. The similarly named Benzo[b]thiophene is an isomer ... Benzo[b]thiophene is more stable and far more commonly encountered. Cava, Michael P.; Lakshmikantham, M. V. (1975). " ... "Nonclassical Condensed Thiophenes". Accounts of Chemical Research. 8: 139-44. doi:10.1021/ar50088a005.CS1 maint: uses authors ...
Introduction of perfluorocarbon chains on the thiophene core affords enhanced thermal stability and volatility, and increased ... Thiophene chemistry and the chemical stability of the thiophene ring hold potential for use of thiophene materials in molecular ... n-Type thiophene semiconductors. US20060186401 *. 14 Sep 2005. 24 Aug 2006. Marks Tobin J. Carbonyl-functionalized thiophene ... n-Type Thiophene Semiconductors. US20090267061 *. 29 Apr 2009. 29 Oct 2009. Marks Tobin J. Carbonyl-Functionalized Thiophene ...
... thiophene-2-carbonyl)oxolan-2-one
... thiophene-2-carbonylamino)benzoate
Thiophene-2-carbothioamide , C5H5NS2 , CID 737237 - structure, chemical names, physical and chemical properties, classification ...
... thiophene 95%; CAS Number: 251-41-2; Synonym: 1,4-Dithiapentalene, 1,4-Thiophthene; Linear Formula: C6H4S2; find Sigma-Aldrich- ... Thieno(3,2-b)thiophene (TT) is an electron rich conjugated polymer that has a quinoidal structure with a narrow band gap. It ... Materials Science, Organic and Printed Electronics, Synthetic Tools and Reagents, Thiophene Monomers and Building Blocks ...
Ethyl thiophene-3-carboxylate , C7H8O2S , CID 79824 - structure, chemical names, physical and chemical properties, ...
Electrophilic Sustitution of Thiophene and Its Derivatives (R. Taylor).. Alkylthiophenes and Their Reactions (P. Cagniant, et ...
Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors.. Ye B1, Arnaiz DO, Chou YL, Griedel BD, ... Investigation of a hit from high-throughput screening identified a series of thiophene-substituted anthranilamides as potent ...
4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID. C13 H9 Br O6 S. QZWUMLLRAVGBHC-UHFFFAOYSA-N. Ligand ... Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48.. Wan, Z.K., Lee, J., Xu ... Bicyclic and Tricyclic Thiophenes as Protein Tyrosine Phosphatase 1B Inhibitors. (2006) Bioorg Med Chem 14: 2162 ... A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural ...
Infrared laser multiple photon excitation/dissociation of Thiophene (Th) was studied as a function of Th pressure, laser pulse ... Infrared laser multiple photon excitation/dissociation of Thiophene (Th) was studied as a function of Th pressure, laser pulse ...
... thiophene was obtained by dropcasting the monomer thiophene onto germanium crystal and the spectrum of the Cu thiophene-capped ... of the free thiophene (a) and Cu thiophene on protected nanoparticles (b) are compared. The lack of the SH stretching of the ... haloalkyl)thiophenes as key building blocks for functionalized thiophenes and polythiophenes," Angewandte Chemie International ... Synthesis of 3-(6-mercaptohexyl)thiophene. The preparation of the monomer 3-(6-mercaptohexyl)thiophene has been performed ...
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Thiophene - Properties. Properties. At room temperature, thiophene is a colorless liquid with a mildly pleasant odor ... The high reactivity of thiophene toward sulfonation is the basis for the separation of thiophene from benzene, which are ... reminiscent of benzene, with which thiophene shares some similarities. ...
Shop a large selection of Heteroaromatic compounds products and learn more about Alfa Aesar Thiophene-2-sulfonyl chloride, 97 ... 2-Thiophenesulfonyl chloride has been used in the preparation of 2-((trans-2-phenyl cyclopropyl)sulfonyl)thiophene. Solubility ... 2-thiophenesulfonyl chloride,2-thienylsulfonyl chloride,thiophene-2-sulphonyl chloride,2-thiophenesulfonylchloride,2- ... 2-thiophenesulfonyl chloride,2-thienylsulfonyl chloride,thiophene-2-sulphonyl chloride,2-thiophenesulfonylchloride,2- ...
Thiophene-3-malonic acid EC Number:. 244-198-9. EC Name:. Thiophene-3-malonic acid. CAS Number:. 21080-92-2 Molecular formula: ... Thiophene-3-malonic acidThiophene-3-malonic acid. CAS Number:. 21080-92-2. Molecular ... Thiophene-3-malonic acidThiophene-3-malonic acid. CAS Number:. 21080-92-2. Molecular ... Thiophene-3-malonic acid Type:. legal entity composition of the substance. State Form:. solid: particulate/powder. Constituent ...
The DFT-based reactivity descriptors were used to elucidate the site selectivity for the chlorination sequence of thiophene. ... sets out to compute thermochemical and geometrical parameters of the complete series of chlorinated isomers of thiophene based ... of chlorobenzene (13.01 ± 0.50 kcal/mol) [26], benzene (19.8 ± 0.2 kcal/mol) [27], thiophene (52.20 kcal/mol) [28], and the for ... at selected temperatures for chlorinated thiophene isomers. in cal/(mol K) and (T) in cal/(mol K). ...
Thiophene,1g (20DA65)? Graingers got your back. Price:$294.50. Easy ordering & convenient delivery. Log-in or register for ...
For the first time it has been established that the adsorption of thiophene and its derivatives on H-mordenite provides ... Physical Chemistry Catalysis Thiophene Resonance Parameter Hyperfine Structure These keywords were added by machine and not by ... For the first time it has been established that the adsorption of thiophene and its derivatives on H-mordenite provides ... Anion-radical formation in the adsorption of thiophene and its derivatives on H-mordenite. ...
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The effect of oxidation on the energetics and structure of thiophene (Th) oligomers is studied with density functional theory ... Journal Article: Density functional theory study of neutral and oxidized thiophene oligomers ...
1-benzothiophene / 2,3,5-trisubstituted thiophene / Benzenoid / Heteroaromatic compound / Thiophene / Boronic acid / Boronic ... 2,3,5-trisubstituted thiophenes / Benzenoids / Heteroaromatic compounds / Boronic acids / Organic metalloid salts / Organoboron ... Benzo[B]Thiophene-2-Boronic Acid. Accession Number. DB04360 (EXPT00787) Type. Small Molecule. Groups. Experimental. Description ... These are aromatic heterocyclic compound containing the Benzo[b]thiophene ring system.. Kingdom. Organic compounds. Super Class ...
Thiophene-based aldehyde derivatives for functionalizable & adhesive semiconducting polymers Emin Istif 1, 2 Daniele Mantione 1 ... Emin Istif, Daniele Mantione, Lorenzo Vallan, Georges Hadziioannou, Cyril Brochon, et al.. Thiophene-based aldehyde derivatives ...
Regioselective palladium-catalyzed arylation of 3-carboalkoxy furan and thiophene.. [Bobby Glover, Kimberly A Harvey, Bing Liu ...
... thiophene isomer (hydrochloride) reference standards from Amphetamines. Available to purchase online at LGC Standards. ...
  • Thiophene derivatives have been detected at nanomole levels in 3.5 billions year old Martian soil sediments (Murray Formation, Pahrump Hills) by the rover Curiosity at Gale crater (Mars) between 2012 and 2017. (wikipedia.org)
  • Electrophilic Sustitution of Thiophene and Its Derivatives (R. Taylor). (wiley.com)
  • Thiophene and its derivatives can be found in some natural resources such as petroleum and coal and in several pharmacologically active compounds [ 2 ]. (hindawi.com)
  • For the first time it has been established that the adsorption of thiophene and its derivatives on H-mordenite provides individual ESR signals with an hyperfine structure. (springer.com)
  • A comparison of the experimental ESR spectra with the calculated magnetic resonance parameters permits to suggest that during the adsorption on HM anion-radicals of thiophene and its derivatives are formed. (springer.com)
  • Hossan ASM, Abu-Melha HMA, Al-Omar MA, Amr AE-G. Synthesis and Antimicrobial Activity of Some New Pyrimidinone and Oxazinone Derivatives Fused with Thiophene Rings Using 2-Chloro-6-ethoxy-4-acetylpyridine as Starting Material. (mdpi.com)
  • Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibit. (nih.gov)
  • Physical Properties of Thiophene Derivatives (S. Gronowitz & A. Hornfeldt). (ellibs.com)
  • Nucleophilic Substitution of Thiophene Derivatives (D. Spinelli, et al. (ellibs.com)
  • Biologically Active Thiophene Derivatives Revisited: 1983 1988 (J. Press). (ellibs.com)
  • The purpose of this study was to synthesize a small library of novel thiophene derivatives, and evaluate its parasitic activity, and potential mechanism of action (MOA). (umass.edu)
  • Overall, eight thiophene derivatives of 5A were synthesized and purified by silica gel column chromatography. (umass.edu)
  • 2, 5-bis(5-Hydroxymethyl-2-thienyl)furan (NSC 652287), is a representative of a series of thiophene derivatives that exhibit potent and selective antitumor activity against several tumor cell lines in the National Cancer Institute Anticancer Drug Screen. (aspetjournals.org)
  • Benzo[c]thiophene is an organic compound with the chemical formula C8H6S. (wikipedia.org)
  • The similarly named Benzo[b]thiophene is an isomer with the sulfur in the position adjacent to the benzene ring. (wikipedia.org)
  • Benzo[b]thiophene is more stable and far more commonly encountered. (wikipedia.org)
  • Benzo[ b ]thiophene heterocycles are important components of many important small molecule pharmaceuticals and drug candidates as well as organic semiconducting materials. (rsc.org)
  • Many methods have been developed for the construction of a benzo[ b ]thiophene core via cyclization reaction of alkynes. (rsc.org)
  • Here we report an efficient method for the synthesis of 2-substituted benzo[ b ]thiophenes from 2-alkynyl thioanisoles catalyzed by a gold( I )-IPr hydroxide that is applicable to a wide range of substrates with diverse electronic and steric properties. (rsc.org)
  • A novel series of HCV NS5B polymerase inhibitors comprising 1,1-dioxoisothiazoles and benzo[b]thiophene-1,1-dioxides were designed, synthesized, and evaluated. (nih.gov)
  • α-Oxoketene Dithioacetals Mediated Benzoannelation of Aromatic Heterocycles: an Efficient Regiocontrolled Synthesis of Highly Substituted and Polycyclic Benzo[b]thiophenes. (alfa.com)
  • Compounds analogous to thiophene include furan (C4H4O) selenophene (C4H4Se) and pyrrole (C4H4NH), which each vary by the heteroatom in the ring. (wikipedia.org)
  • Heating at high temperature (500° to 820 °C) of lacustrine mudstone samples by the Sample Analysis at Mars (SAM) instrument allowed gas chromatography-mass spectrometry (GC-MS) analyses of the evolved gases and the detection of aromatic and aliphatic molecules including several thiophene compounds. (wikipedia.org)
  • The Gewald reaction of PEG-bound cyanoacetic ester, elemental sulfur, DIPEA and carbonyl compounds carried out under microwave irradiation afforded PEG-supported thiophenes, which were acylated and treated with 1% KCN in methanol to give free thiophenes in good yields. (organic-chemistry.org)
  • Compounds analogous to thiophene include furan (C 4 H 4 O) and pyrrole (C 4 H 4 NH). (academic.ru)
  • The slight variations observed in the pKa values of the thiophene compound compared to the pyrrol analogue revealed that neither of the two hetero atoms in the pyrrol or thiophene rings, of the two compounds, is involved in a hydrogen bond chelation. (scirp.org)
  • Development of Thiophene Compounds as Potent Chemotherapies for the Tr" by Felipe Rodriguez, Eva Iniguez et al. (umass.edu)
  • We identified three SERMs (one selenophene and two thiophene-core compounds) with potent inhibitory activities (at 3-25 μM) on the motility and development of parasitic stages of H. contortus . (biomedcentral.com)
  • The first synthesis of thiophene by Meyer, reported the same year that he made his discovery, involves acetylene and elemental sulfur. (wikipedia.org)
  • Here, the synthesis of thiophene based optical ligands, denoted bi-thiophene-vinyl-benzothiazoles (bTVBTs) that can be utilized for selective assignment of tau aggregates in brain tissue with Alzheimers disease (AD) pathology is reported. (diva-portal.org)
  • Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones, e.g. acetylenes and elemental sulfur, which was the first synthesis of thiophene by Viktor Meyer in the year of its discovery. (academic.ru)
  • A novel method for the synthesis of thiophene 1,1-dioxides by oxidation of substituted thiophenes with trifluoroperoxyacetic acid was developed. (springer.com)
  • By attaching an azide functional group via a tetraethylene glycol linker to the α-terminal position of a variety of oligothiophenes, thiophene-based ligands that can be utilized for detection of protein aggregates with surface plasmon resonance have been developed. (diva-portal.org)
  • In addition, by alteration of the backbone (change of thiophene units), and of adding different side chains functionalities, we have shown that the properties of the amyloid ligands have a huge impact of the binding to different stages or forms of protein aggregates. (diva-portal.org)
  • Herein, the solvatochromism of a library of anionic pentameric thiophene-based ligands, as well as their ability to spectrally discriminate Aβ and tau aggregates, were investigated. (diva-portal.org)
  • Overall, the results from this study identified distinct solvatochromic and viscosity-dependent behavior of thiophene-based ligands that can be applied as indices to direct the chemical design of improved LCOs for spectral separation of Aβ and tau aggregates in brain tissue sections. (diva-portal.org)
  • We foresee that these findings might aid in the chemical design of thiophene-based ligands that are increasingly selective for distinct disease-associated protein aggregates. (diva-portal.org)
  • Thiophene was discovered as a contaminant in benzene. (wikipedia.org)
  • These reagents are contacted with an oxide catalyst at 500-550 °C. At room temperature, thiophene is a colorless liquid with a mildly pleasant odor reminiscent of benzene, with which thiophene shares some similarities. (wikipedia.org)
  • The high reactivity of thiophene toward sulfonation is the basis for the separation of thiophene from benzene, which are difficult to separate by distillation due to their similar boiling points (4 °C difference at ambient pressure). (wikipedia.org)
  • Like benzene, thiophene forms an azeotrope with ethanol. (wikipedia.org)
  • Thiophene is considered to be aromatic, although theoretical calculations suggest that the degree of aromaticity is less than that of benzene. (wikipedia.org)
  • At room temperature, thiophene is a colorless liquid with a mildly pleasant odor reminiscent of benzene , with which thiophene shares some similarities. (primidi.com)
  • 4.2 This test method was found applicable for determining thiophene in refined benzene conforming to the specifications described in Specification D2359 and may be applicable toward other grades of benzene if the user has taken the necessary precautions as described in the text. (astm.org)
  • 1.1 This test method covers the determination of thiophene in refined benzene in the range from 0.80 to 1.80 mg/kg for the Flame Photometric Detector (FPD), and from 0.14 to 2.61 mg/kg for the Pulsed Flame Photometric Detector (PFPD). (astm.org)
  • 1.2 This test method has been found applicable to benzene characteristic of the type described in Specifications D2359 and D4734 and may be applicable to other types or grades of benzene only after the user has demonstrated that the procedure can completely resolve thiophene from the other organic contaminants contained in the sample. (astm.org)
  • We examined the thermal crystallization of deposited films made of 2,5-bis(4-biphenylyl)thiophene (BP1T) and 1,4-bis(5-phenylthiophen-2-yl)benzene (AC5), which are thiophene/phenylene co-oligomers (TPCOs). (spie.org)
  • Related to thiophene are benzothiophene and dibenzothiophene, containing the thiophene ring fused with one and two benzene rings, respectively. (academic.ru)
  • Thiophene is considered aromatic, although theoretical calculations suggest that the degree of aromaticity is less than that of benzene. (academic.ru)
  • Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. (nih.gov)
  • Investigation of a hit from high-throughput screening identified a series of thiophene-substituted anthranilamides as potent nonamidine fXa inhibitors. (nih.gov)
  • A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. (rcsb.org)
  • Regioselective palladium-catalyzed arylation of 3-carboalkoxy furan and thiophene. (sigmaaldrich.com)
  • A copolymer comprising 1,4-diketopyrrolo[3,4- c ]pyrrole (DPP) and thieno[3,2- b ]thiophene moieties, PDBT-co-TT, shows high hole mobility of up to 0.94 cm 2 V −1 s −1 in organic thin-film transistors. (wiley.com)
  • In this study, we report the development of an enzyme immobilization matrix that displays enhanced electrochemical performance thanks to a novel conductive thin film prepared via in situ electrocopolymerization of pyrrole (Py) and thiophene-grafted chitosan (Th-Ch). This is a simple thin film preparation method that can help overcome aforementioned challenges by providing a uniformly distributed conductive layer on the electrode. (monash.edu)
  • The polymers based on di-thiophene and benzothiadiazole were applied in photovoltaic devices and the coupling of the alkylthiophene showed no effect on the maximum photovoltaic performance. (spie.org)
  • Band-gaps were estimated to be 2 eV for polymers based on di-thiophene and benzothiadiazole and 1.8 eV for polymers based on quarterthiophene and benzothiadiazole. (spie.org)
  • Poly(3,4-ethylenedioxy)thiophene−poly(styrene sulfonate) (PEDOT−PSS) was used as the conductive component in a matrix of chemically different insulating polymers to form an array of vapor detectors. (caltech.edu)
  • Thus, thiophene itself is converted to butane and H 2 S. More prevalent and more problematic in petroleum are benzothiophene and dibenzothiophene. (academic.ru)
  • 8. The field effect transistor of claim 7 , where said polythiophene polymer is regioregular, head-to-tail poly-3-C n F 2n+1 -thiophene. (google.co.uk)
  • 3-Thiophenecarboxylic acid has been used in the preparation of novel acetylene monomer, required for the synthesis of poly(2-methylbut-2-enyl thiophene-3-carboxylate) and oxazolines and oxazoles. (alfa.com)
  • This research describes the preparation and sensor applications of multifunctional monodisperse, Fe 3 O 4 nanoparticles-embedded poly(styrene)/poly(thiophene) (Fe 3 O 4 -PSt/PTh), core/shell nanoparticles. (mdpi.com)
  • Kim, J.H. Preparation of Fe 3 O 4 -Embedded Poly(styrene)/Poly(thiophene) Core/Shell Nanoparticles and Their Hydrogel Patterns for Sensor Applications. (mdpi.com)
  • Direct current and alternating current electrical transport properties of regioregular poly[3-(4-alkoxyphenyl)-thiophenes]. (unina.it)
  • transport properties of doped and undoped regioregular poly[3-(4-alkoxyphenyl)-thiophenes], where the alkoxy groups are O-(CH2)n-1CH3 with n = 1,4,6, and 8, have been investigated. (unina.it)
  • Nucleation and growth mechanisms of poly(thiophene) Part 1. (semanticscholar.org)
  • Various poly[3-(4-octylphenyl)thiophene]s (POPTs) were prepared either by oxidative polymerisation or by chain-growth Grignard metathesis (GRIM). (epjap.org)
  • In this work we present the effect of HiPCO single walled carbon nanotubes (SWCNT) introduction into the conjugated polymer matrix poly(3-hexyl thiophene) (P3HT) on the structural and thermal stability of these nanocomposites. (epjap.org)
  • Thieno(3,2- b )thiophene (TT) is an electron rich conjugated polymer that has a quinoidal structure with a narrow band gap. (sigmaaldrich.com)
  • The DFT-based reactivity descriptors were used to elucidate the site selectivity for the chlorination sequence of thiophene. (hindawi.com)
  • Synthesis and reactivity of thiophene palladium and thiophene dipalladium complexes with unsaturated molecules. (docme.ru)
  • examples of insertion of CO into thiophene-palladium (II) complexes leading to acylpalladium (II) complexes have been reported.12 In this paper, we wish to present the reactivity of novel thiophene-palladium complexes, in particular their reactions with different molarities of CO and isocyanides. (docme.ru)
  • We provide independent and unbiased information on manufacturers, prices, production news and consumers for the global and regional (North America, Asia and Europe) market of Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate. (reportsnreports.com)
  • 7. The field effect transistor of claim 6 , where said polythiophene polymer contains fluoroalkyl substituents attached to the 3-position of the thiophene rings in a regioregular, head-to-tail configuration. (google.co.uk)
  • Thiophene is a heterocyclic compound with the formula C4H4S. (wikipedia.org)
  • Thiophene (C 4 H 4 S) is a heterocyclic organic compound with a five-membered ring similar to cyclopentadiene with replacement of a -CH 2 - group by sulfur atom [ 1 ]. (hindawi.com)
  • Thiophene is the heterocyclic compound with the formula C 4 H 4 S. Consisting of a flat five-membered ring, it is aromatic as indicated by its extensive substitution reactions. (academic.ru)
  • This new heterocyclic compound was thiophene. (academic.ru)
  • Viktor Meyer was able to isolate thiophene as the actual substance responsible for this reaction. (wikipedia.org)
  • The solubility of the polymer based on quarterthiophene and benzothiadiazole was tested with hexyl, 2-ethyl-hexyl and dodecyl as side chains on the thiophene. (spie.org)
  • Such thiophene derivative that is often used in medicinal chemistry is the α -chlorothiophene, and there are several examples of marketed drugs containing this moiety such as tioconazole, lornoxicam, and rivaroxaban [ 4 ]. (hindawi.com)
  • Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. (wikipedia.org)
  • Specialized thiophenes can be synthesized similarly using Lawesson's reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. (wikipedia.org)
  • Oxidation can occur both at sulfur, giving a thiophene S-oxide, as well as at the 2,3-double bond, giving the thiophene 2,3-epoxide, followed by subsequent NIH shift rearrangement. (wikipedia.org)
  • 6. The field effect transistor device of claim 1 wherein said n-type organic semiconducting material is a polythiophene polymer with more than seven conjugated thiophene moieties. (google.co.uk)
  • The use of thiophene polymer film as an electrochromic material for display devices is proposed. (ip.com)
  • The global market size of 2-Thiophene Acetyl Chloride is $XX million in 2017 with XX CAGR from 2013 to 2017, and it is expected to reach $XX million by the end of 2023 with a CAGR of XX% from 2018 to 2023. (marketpublishers.com)
  • The effect of oxidation on the energetics and structure of thiophene (Th) oligomers is studied with density functional theory at the B3PW91/6-311++G(d,p) level. (osti.gov)
  • The effect of the solvent nature on the course of the reaction was studied and optimum conditions for the oxidation of thiophenes containing various functional groups were found. (springer.com)
  • On the contrary, the formation of furans, with the only exception of C 4 H 8 O, seems to be favoured at oxidizing conditions and relatively high temperatures, although mechanisms similar to those hypothesized for the production of thiophenes can be suggested. (mdpi.com)
  • A titanium-based zeolitic thiophene-benzimidazolate framework has been designed for the direct synthesis of dimethyl carbonate (DMC) from methanol and carbon dioxide. (epa.gov)
  • The ' Global and Chinese 2-Thiophene Methanol Industry, 2011-2021 Market Research Report ' is a professional and in-depth study on the current state of the global 2-Thiophene Methanol industry with a focus on the Chinese market. (marketresearch.com)
  • The report provides key statistics on the market status of the 2-Thiophene Methanol manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. (marketresearch.com)
  • Through the statistical analysis, the report depicts the global and Chinese total market of 2-Thiophene Methanol industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. (marketresearch.com)
  • The report then estimates 2016-2021 market development trends of 2-Thiophene Methanol industry. (marketresearch.com)
  • In the end, the report makes some important proposals for a new project of 2-Thiophene Methanol Industry before evaluating its feasibility. (marketresearch.com)
  • Overall, the report provides an in-depth insight of 2011-2021 global and Chinese 2-Thiophene Methanol industry covering all important parameters. (marketresearch.com)
  • 5.2 Market Competition of 2-Thiophene Methanol Industry by Country (USA, EU, Japan, Chinese etc. (marketresearch.com)
  • polymerization of 3,4-ethylenedioxy-thiophene (PEDT) was investigated in neutral aqueous solution by electrochemical method. (cnki.com.cn)
  • Enclosed functional groups of MP are structural alerts for metabolic activation to reactive intermediates: thiophene ring ( S -oxide and epoxide), pyridine ring (epoxide and p -quinone iminium ion), and alkyl nitrogens (iminium ions). (aspetjournals.org)
  • This contribution sets out to compute thermochemical and geometrical parameters of the complete series of chlorinated isomers of thiophene based on the accurate chemistry model of CBS-QB3. (hindawi.com)
  • Medicinal chemistry approaches to minimize the bioactivation potential of thiophenes often include substitution at the α -carbon position to provide a potential site for metabolism. (hindawi.com)
  • Jonathan Swanston "Thiophene" in Ullmann's Encyclopedia of Industrial Chemistry Wiley-VCH, Weinheim, 2006. (academic.ru)
  • The UV/visible spectra of 3,4-diphenyl thiophene were obtained in various solvents (both polar and non polar). (ajol.info)
  • Introduction of perfluorocarbon chains on the thiophene core affords enhanced thermal stability and volatility, and increased electron affinity versus the fluorine-free analog 2. (google.co.uk)
  • We present a comprehensive study of resonance formation in electron collisions with thiophene. (open.ac.uk)
  • The results highlight the importance of the modifications ported to the well-known one-phase synthetic reactions to obtain a clear lack, even after a storage of six months, of any irreversible aggregation that has always characterized chain thiophene-protected metallic nanoparticles. (hindawi.com)
  • We developed a structure-activity relationship (SAR) study of the thiophene molecule 5A . (umass.edu)
  • Thiophenes undergo hydrogenolysis to form hydrocarbons and hydrogen sulfide. (wikipedia.org)
  • Mass spectrometric and hydrogen/deuterium exchange analysis of the glutathione adduct produced by rat liver microsomes indicated that the metabolite was most probably a thioether of MP S -oxide substituted in the thiophene ring. (aspetjournals.org)
  • The occurrence, toxicity, and uses of thiophenes are discussed in order to provide the setting within which analyses must be performed. (cdc.gov)
  • Thiophene has high potential for bioactivation which in some cases has been linked to toxicity [ 3 ]. (hindawi.com)
  • 29 , 30 Motivated by all the above, we selected two isomeric monomers in which a thiophene ring is attached at either the 2‐ or 3‐ position to pyrene at its 1‐, 3‐, 6‐, and 8‐ positions. (pubmedcentralcanada.ca)
  • 2,2-(thiophene-2,5-diyl)bis[5-(1,1-dimethylethyl)]-benzoxazole manufacturers and suppliers with contacts and product range are mentioned in the study. (marketpublishers.com)
  • Measured and calculated properties of thiophenes are given. (cdc.gov)
  • As a consequence of its aromaticity, thiophene does not exhibit the properties seen for conventional sulfides. (wikipedia.org)
  • The effects of the number and the position of the chlorine atoms on the properties of the thiophene ring for the chlorothiophenes have been studied theoretically by the CBS-QB3 composite method [ 14 ]. (hindawi.com)
  • 3. The field effect transistor device of claim 1 wherein said n-type organic semiconducting material contains about four to about seven conjugated thiophene moieties. (google.co.uk)
  • language = {cze}, issn = {0009-2770}, journal = {Chemické listy}, title = {Esters and Nitriles of 2-(3-Acylselenoureido)benzoic and -thiophene-3-carboxylic Acids Thermal Transformations. (muni.cz)
  • Thermal behaviour of esters and nitriles of 2-(3-acylselenoureido)benzoic and -thiophene-3-carboxylic acids in solid phase and melt were studied. (muni.cz)