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ThiophenesFuransEchinops PlantChemistry Techniques, SyntheticAnisolesMolecular StructureCyclizationHeterocyclic CompoundsPalladiumSulfur CompoundsCombinatorial Chemistry TechniquesStructure-Activity RelationshipStereoisomerismCatalysisSemiconductorsTransistors, ElectronicSublimationPatents as TopicCadmium CompoundsBromine CompoundsTerminology as TopicSafetyAccidents, OccupationalDatabases, ChemicalFactor XaPubMedPeriodicals as TopicBooksPublishingMEDLINESerial PublicationsDatabases, ProteinInternetUser-Computer InterfaceCrystallography, X-RayModels, MolecularSoftwareInfrared RaysLasersPhotonsLaser Therapy, Low-LevelLasers, SemiconductorLaser TherapyQuantum TheoryMolecular ConformationThermodynamicsElectronsTransition ElementsPolymersElectroplatingQuantum DotsBicyclo Compounds, HeterocyclicElectronicsMolecular Imaging
ThiophenesFurans: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.Echinops Plant: A plant genus of the family ASTERACEAE. Members contain a pseudoguaiane sesquiterpene. San-fang-feng is the root of E. grijisii used in DRUGS, CHINESE HERBAL.Chemistry Techniques, Synthetic: Methods used for the chemical synthesis of compounds. Included under this heading are laboratory methods used to synthesize a variety of chemicals and drugs.Anisoles: A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Sulfur Compounds: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.Combinatorial Chemistry Techniques: A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Semiconductors: Materials that have a limited and usually variable electrical conductivity. They are particularly useful for the production of solid-state electronic devices.Transistors, Electronic: Electrical devices that are composed of semiconductor material, with at least three connections to an external electronic circuit. They are used to amplify electrical signals, detect signals, or as switches.Sublimation: A defense mechanism through which unacceptable impulses and instinctive urges are diverted into personally and socially acceptable channels; e.g., aggression may be diverted through sports activities.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Cadmium Compounds: Inorganic compounds that contain cadmium as an integral part of the molecule.Bromine Compounds: Inorganic compounds that contain bromine as an integral part of the molecule.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Safety: Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.Accidents, Occupational: Unforeseen occurrences, especially injuries in the course of work-related activities.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Factor Xa: Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Infrared Rays: That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.Lasers: An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.Photons: Discrete concentrations of energy, apparently massless elementary particles, that move at the speed of light. They are the unit or quantum of electromagnetic radiation. Photons are emitted when electrons move from one energy state to another. (From Hawley's Condensed Chemical Dictionary, 11th ed)Laser Therapy, Low-Level: Treatment using irradiation with LASER light of low power intensity so that the effects are not due to heat, as they are in LASER THERAPY.Lasers, Semiconductor: Lasers with a semiconductor diode as the active medium. Diode lasers transform electric energy to light using the same principle as a light-emitting diode (LED), but with internal reflection capability, thus forming a resonator where a stimulated light can reflect back and forth, allowing only a certain wavelength to be emitted. The emission of a given device is determined by the active compound used (e.g., gallium arsenide crystals doped with aluminum or indium). Typical wavelengths are 810, 1,060 and 1,300 nm. (From UMDNS, 2005)Laser Therapy: The use of photothermal effects of LASERS to coagulate, incise, vaporize, resect, dissect, or resurface tissue.Quantum Theory: The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck's constant and v is the frequency of the radiation.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Thermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Electrons: Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.Transition Elements: Elements with partially filled d orbitals. They constitute groups 3-12 of the periodic table of elements.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Electroplating: Coating with a metal or alloy by electrolysis.Quantum Dots: Nanometer sized fragments of semiconductor crystalline material which emit PHOTONS. The wavelength is based on the quantum confinement size of the dot. They can be embedded in MICROBEADS for high throughput ANALYTICAL CHEMISTRY TECHNIQUES.Bicyclo Compounds, Heterocyclic: A class of saturated compounds consisting of two rings only, having two or more atoms in common, containing at least one hetero atom, and that take the name of an open chain hydrocarbon containing the same total number of atoms. (From Riguady et al., Nomenclature of Organic Chemistry, 1979, p31)Electronics: The study, control, and application of the conduction of ELECTRICITY through gases or vacuum, or through semiconducting or conducting materials. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Molecular Imaging: The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; FLUORESCENCE IMAGING; and MICROSCOPY.

Microbial desulfurization of organic sulfur compounds in petroleum. (1/1894)

Sulfur removal from petroleum is important from the standpoint of the global environment because the combustion of sulfur compounds leads to the production of sulfur oxides, which are the source of acid rain. As the regulations for sulfur in fuels become more stringent, the existing chemical desulfurizations are coming inadequate for the "deeper desulfurization" to produce lower-sulfur fuels without new and innovative processes. Biodesulfurization is rising as one of the candidates. Several microorganisms were found to desulfurize dibenzothiophene (DBT), a representative of the organic sulfur compounds in petroleum, forming a sulfur-free compound, 2-hydroxybiphenyl. They are promising as biocatalysts in the microbial desulfurization of petroleum because without assimilation of the carbon content, they remove only sulfur from the heterocyclic compounds which is refractory to conventional chemical desulfurization. Both enzymological and molecular genetic studies are now in progress for the purpose of obtaining improved desulfurization activity of organisms. The genes involved in the sulfur-specific DBT desulfurization were identified and the corresponding enzymes have been investigated. From the practical point of view, it has been proved that the microbial desulfurization proceeds in the presence of high concentrations of hydrocarbons, and more complicated DBT analogs are also desulfurized by the microorganisms. This review outlines the progress in the studies of the microbial desulfurization from the basic and practical point of view.  (+info)

5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. (2/1894)

We previously demonstrated a change in the receptors mediating 5-hydroxytryptamine (5-HT)-induced contraction in arteries of deoxycorticosterone acetate (DOCA)-salt-hypertensive rats. Specifically, contraction to 5-HT is mediated primarily by 5-HT2A receptors in arteries from normotensive sham rats and by both 5-HT2A and 5-HT2B receptors in arteries from hypertensive rats. We hypothesized that the 5-HT2B receptor may play a role in maintaining the high blood pressure of DOCA-salt-hypertensive rats, and herein we provide data connecting in vitro and in vivo findings. The endothelium-denuded isolated superior mesenteric artery of DOCA-salt rats displayed a marked increase in maximum contraction to the newly available 5-HT2B-receptor agonist BW-723C86 compared with that of arteries from sham rats, confirming that the 5-HT2B receptor plays a greater role in 5-HT-induced contraction in arteries from DOCA-salt rats. In chronically instrumented rats, the 5-HT2B-receptor antagonist LY-272015 (0.3, 1.0, and 3.0 mg/kg iv at 30-min intervals) was given cumulatively 1 time/wk during 4 wk of continued DOCA-salt treatment. LY-272015 did not reduce blood pressure of the sham-treated rats at any time or dose. However, LY-272015 (1.0 and 3. 0 mg/kg) significantly reduced mean blood pressure in a subgroup of week 3 (-20 mmHg) and week 4 DOCA-salt (-40 mmHg) rats that had extremely high blood pressure (mean arterial blood pressure approximately 200 mmHg). Blockade of 5-HT2B receptors by in vivo administration of LY-272015 (3.0 mg/kg) was verified by observing reduced 5-HT-induced contraction in rat stomach fundus, the tissue from which the 5-HT2B receptor was originally cloned. These data support the novel hypothesis that 5-HT2B-receptor expression is induced during the development of DOCA-salt hypertension and contributes to the maintenance of severe blood pressure elevations.  (+info)

Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. (3/1894)

HER2/neu, a Mr 185,000 tyrosine kinase receptor that is overexpressed in breast cancer, undergoes proteolytic cleavage of its extracellular domain (ECD). In contrast with other membrane-bound proteins, including growth factor receptors, that are cleaved by a common machinery system, we show that HER2 cleavage is a slow process and is not activated by protein kinase C. Pervanadate, a general inhibitor of protein-tyrosine phosphatases, induces a rapid and potent shedding of HER2 ECD. The shedding of HER2 ECD is inhibited by the broad-spectrum metalloprotease inhibitors EDTA, TAPI-2, and batimastat. The tissue inhibitor of metalloproteases-1; an inhibitor of matrix metalloproteases that does not inhibit cleavage by the general protein kinase C-dependent shedding machinery, also inhibited HER2 ECD shedding, whereas tissue inhibitor of metalloproteases-2 did not. These data suggest that HER2 cleavage is a process regulated by an as-yet-unidentified distinct protease.  (+info)

Phase I study of intrapleural batimastat (BB-94), a matrix metalloproteinase inhibitor, in the treatment of malignant pleural effusions. (4/1894)

Tumor cells and associated stromal cells secrete matrix metalloproteinases (MMPs), contributing to invasion, angiogenesis, and metastasis. Batimastat (BB-94) is a broad-spectrum MMP inhibitor that causes resolution of ascites and/or tumor growth delay in animal models of breast, ovarian, and colorectal cancer. We recruited 18 patients with cytologically positive malignant pleural effusions into a Phase I study of intrapleural BB-94. Three patients received single doses of BB-94 at each dose level: 15, 30, 60, 105, 135, and 300 mg/m2. Two patients were retreated with a second course at 60 and 105 mg/m2. BB-94 was detectable in plasma 1 h after intrapleural administration, and peak levels of 20-200 ng/ml occurred after 4 h to 1 week. BB-94 persisted in the plasma for up to 12 weeks, at levels exceeding the IC50s for target MMPs. Peak values were higher, and persistence in the plasma was longer after higher doses of BB-94. The treatment was well tolerated. Toxic effects included low-grade fever for 24-48 h (6 of 18 patients, 33%) and reversible asymptomatic elevation of liver enzymes (8 patients, 44%). Toxicity seemed unrelated to BB-94 dose or plasma levels. Sixteen patients evaluable for response required significantly fewer pleural aspirations in the 3 months after BB-94 compared with the 3 months before. Seven patients (44%) required no further pleural aspiration until death/last follow-up. After 1 month, patients treated with 60-300 mg/m2 BB-94 had significantly better dyspnea scores, indicating improved exercise tolerance, compared with baseline scores the day after BB-94. The maximum tolerated intrapleural dose remains to be defined, but it is clear that intrapleural BB-94 is well tolerated, with evidence of local activity.  (+info)

Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenan-airpouch inflammation. (5/1894)

1. Cyclo-oxygenase-2 (COX-2) is expressed at sites of inflammation and is believed to be the major source of inflammation-associated prostaglandin synthesis. Selective inhibition of COX-2 has been suggested to produce anti-inflammatory effects with reduced toxicity in the gastrointestinal tract. We examined the extent to which suppression of COX-2 led to inhibition of various components of inflammation in the carrageenan-airpouch model in the rat. 2. Indomethacin (> or =0.3 mg kg(-1)), nimesulide (> or =3 mg kg(-1)) and the selective COX-2 inhibitor, SC-58125 (> or =0.3 mg kg(-1)), significantly suppressed the production of prostaglandin E2 at the site of inflammation. At higher doses, indomethacin (> or =1 mg kg(-1)) and nimesulide (30 mg kg(-1)), but not SC-58125 (up to 10 mg kg(-1)), significantly inhibited COX-1 activity (as measured by whole blood thromboxane synthesis). 3. All three test drugs significantly reduced the volume of exudate in the airpouch, but only at doses greater than those required for substantial (>90%) suppression of COX-2 activity. Similarly, reduction of leukocyte infiltration was only observed with the doses of indomethacin and nimesulide that caused significant suppression of COX-1 activity. 4. SC-58125 did not significantly affect leukocyte infiltration into the airpouch at any dose tested (up to 10 mg kg(-1)). A second selective COX-2 inhibitor, Dup-697, was also found to suppress exudate PGE2 levels without significant effects on leukocyte infiltration. 5. These results indicate that selective inhibition of COX-2 results in profound suppression of PGE2 synthesis in the carrageenan-airpouch, but does not affect leukocyte infiltration. Exudate volume was only reduced with the highly selective COX-2 inhibitor when a dose far above that necessary for suppression of COX-2 activity was used. Inhibition of leukocyte infiltration was observed with indomethacin and nimesulide, but only at doses that inhibited both COX-1 and COX-2.  (+info)

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. (6/1894)

Solid tumors depend on angiogenesis for their growth. In a transgenic mouse model of pancreatic islet cell carcinogenesis (RIP1-Tag2), an angiogenic switch occurs in premalignant lesions, and angiogenesis persists during progression to expansive solid tumors and invasive carcinomas. RIP1-Tag2 mice were treated so as to compare the effects of four angiogenesis inhibitors at three distinct stages of disease progression. AGM-1470, angiostatin, BB-94, and endostatin each produced distinct efficacy profiles in trials aimed at preventing the angiogenic switch in premalignant lesions, intervening in the rapid expansion of small tumors, or inducing the regression of large end-stage cancers. Thus, anti-angiogenic drugs may prove most efficacious when they are targeted to specific stages of cancer.  (+info)

Marked suppression of T cells by a benzothiophene derivative in patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (7/1894)

In a search for new anti-autoimmune agents that selectively suppress activation of autoreactive T cells, one such agent, 5-methyl-3-(1-methylethoxy)benzo[b]thiophene-2-carboxamide (CI-959-A), was found to be effective. This compound, which is known to suppress tumor necrosis factor alpha (TNF-alpha)-induced CD54 expression, inhibited the primary proliferative response of the T cell to antigen (Ag)-presenting cells (APCs) including allogenic dendritic cells (DCs), autologous Epstein-Barr virus-infected B cells, and human T lymphotropic virus type I (HTLV-I)-infected T cells. Autoreactive T cells from patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) spontaneously proliferate in vitro, and their activation is reported to be associated with CD54 expression. The spontaneous proliferation of T cells from patients with HAM/TSP was entirely blocked by CI-959-A. However, in this study, the T-cell proliferation in 15 patients with HAM/TSP was found to depend more extensively on major histocompatibility complex (MHC) class II and CD86 than on CD54 Ags. Since most important APCs for the development of HAM/TSP are DCs and HTLV-I-infected T cells, the effect of CI-959-A on DC generation and on the expression of surface molecules on activated T cells is examined. CI-959-A suppressed recombinant granulocyte-macrophage colony stimulating factor (GM-CSF)- and recombinant interleukin-4-dependent differentiation of DCs from monocytes and inhibited the expression of CD54 and, more extensively, MHC class II and CD86 Ags. CI-959-A showed little toxicity toward lymphoma or HTLV-I-infected T-cell lines or toward monocytes and cultured DCs. These results suggest that CI-959-A might be a potent anti-HAM/TSP agent.  (+info)

Dorzolamide effect on ocular blood flow. (8/1894)

PURPOSE: To evaluate the effect of dorzolamide on ocular blood flow in normal and glaucomatous eyes. METHODS: Twenty-six eyes with documented open-angle glaucoma of 26 patients and 13 normal control eyes of 8 age-matched subjects were included in this study. All eyes underwent color Doppler imaging for measuring peak-systolic velocity, end-diastolic velocity, and resistance index in the ophthalmic and central retinal arteries and the maximal and minimal velocities in the central retinal vein. Eyes were grouped in control and initial and advanced glaucoma categories. Measurements were made in all groups before and after application of topical dorzolamide. Intragroup comparisons between baseline and dorzolamide conditions were made using paired Student's t-test. Intergroup comparisons under baseline conditions between normal and glaucomatous eyes were made by using the one-way ANOVA test. Statistical significance was set at P < 0.05. RESULTS: The peak-systolic velocity of the central retinal artery in glaucomatous eyes and the end-diastolic velocity of the ophthalmic and central retinal arteries in all groups were significantly higher after application of dorzolamide. The minimal velocity of the central retinal vein showed significantly higher values after dorzolamide, whereas the maximal velocity remained unchanged. The peak-systolic velocity of the ophthalmic artery in all groups and the peak-systolic velocity of the central retinal artery in normal eyes also remained unchanged. The resistance index was significantly lower in the ophthalmic and central retinal arteries in all groups after dorzolamide. The intraocular pressure was significantly reduced in all groups after dorzolamide. Under baseline conditions normal control eyes and glaucomatous eyes showed differences in various measurements. Peak-systolic velocity was significantly lower in glaucomatous eyes than in normal control eyes with the exception of the ophthalmic artery in the initial glaucoma group. End-diastolic velocity was lower in glaucomatous eyes than in control eyes in both arteries. Maximal and minimal velocities of the central retinal vein were lower in glaucomatous eyes than in normal control eyes. Resistance index was higher in glaucomatous eyes than in normal control eyes in the ophthalmic artery but not in the central retinal artery. CONCLUSIONS: Most hemodynamic parameters of intraocular and periocular vessels improve after application of topical dorzolamide in both normal control and glaucomatous eyes. Dorzolamide should be regarded as a useful drug for treatment of glaucoma not only because it reduces intraocular pressure but also because it improves the ocular blood supply.  (+info)

Synthesis and biological evaluation of thiophene and benzo[b]thiophene analogs of combretastatin A-4 and isocombretastatin A-4:...Synthesis and biological evaluation of thiophene and benzo[b]thiophene analogs of combretastatin A-4 and isocombretastatin A-4:...
Show more ,Combretastatin A-4 and isocombretastatin A-4 derivatives having thiophenes or benzo[b]thiophenes instead of the B ring were prepared and evaluated for their in cellulo tubulin polymerization inhibition (TPI) and antiproliferative activities. The presence of the benzo[b]thiophene ring proved to have a crucial effect as most of the thiophene derivatives, except those having one methoxy group, were inactive to inhibit tubulin polymerization into microtubules. The influence of the attachment position was also studied: benzo[b]thiophenes having iso or cis 3,4,5-trimethoxystyrenes at position 2 were 12-30-fold more active than the 3-regioisomers for the TPI activity. Some of the novel designed compounds exhibited interesting anti-proliferative effects on two different cell lines.Show less , ...
Europe Benzo[b]thiophene-2-carboxaldehyde (CAS 3541-37-5) Market Report (2014-2024) - Market Size, Share, Price, Trend and...Europe Benzo[b]thiophene-2-carboxaldehyde (CAS 3541-37-5) Market Report (2014-2024) - Market Size, Share, Price, Trend and...
Abstract:. Ask for Free Sample @ WMR- https://westernmarketresearch.com/sample-report/1144642/Europe Benzo[b]thiophene-2-carboxaldehyd#sample. The Europe Benzo[b]thiophene-2-carboxaldehyde market size is $XX million USD in 2018 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million USD by the end of 2024 with a CAGR of XX% from 2019 to 2024.. Ask for Free Sample-Inquiry and Discount @WMR- https://westernmarketresearch.com/market-report/1144642/Europe Benzo[b]thiophene-2-carboxaldehyd#inquiry. This report is an essential reference for who looks for detailed information on Europe Benzo[b]thiophene-2-carboxaldehyde market. The report covers data on Europe markets including historical and future trends for supply, market size, prices, trading, competition and value chain as well as Europe major vendors°Ø information. In addition to the data part, the report also provides overview of Benzo[b]thiophene-2-carboxaldehyde market, including classification, application, manufacturing ...
Human Metabolome Database: Showing metabocard for Thiophene (HMDB0029718)Human Metabolome Database: Showing metabocard for Thiophene (HMDB0029718)
Thiophene is a maillard product At room temperature, thiophene is a colorless liquid with a mildly pleasant odor reminiscent of benzene, with which thiophene shares some similarities. The high reactivity of thiophene toward sulfonation is the basis for the separation of thiophene from benzene, which are difficult to separate by distillation due to their similar boiling points (4 C difference at ambient pressure). Like benzene, thiophene forms an azeotrope with water. Not only is thiophene reactive toward electrophiles, it is also readily lithiated with butyl lithium to give 2-lithiothiophene, which is a precursor to a variety of derivatives, including ...
3-Chlorothieno[2,3-b]thiophene-2-carboxylic acid, 97%, Maybridge Amber Glass Bottle; 1g 3-Chlorothieno[2,3-b]thiophene-2...3-Chlorothieno[2,3-b]thiophene-2-carboxylic acid, 97%, Maybridge Amber Glass Bottle; 1g 3-Chlorothieno[2,3-b]thiophene-2...
3-Chlorothieno[2,3-b]thiophene-2-carboxylic acid, 97%, Maybridge Amber Glass Bottle; 1g 3-Chlorothieno[2,3-b]thiophene-2-carboxylic acid, 97%, Maybridge Chlorot to...
Thiophene Derivatives | Spectrum ChemicalThiophene Derivatives | Spectrum Chemical
Get Thiophene Derivatives at Spectrum Chemical. SpectrumChemical.com carries a full line of fine chemicals, lab appliances and lab supplies. Spectrum Chemical offers fine chemicals in lab and production sizes.
DGIST Scholar: Detection of C-reactive protein on a functional poly(thiophene) self-assembled monolayer using surface plasmon...DGIST Scholar: Detection of C-reactive protein on a functional poly(thiophene) self-assembled monolayer using surface plasmon...
The preparation of a new poly(thiophene) with pendant N-hydroxysuccinimide ester groups and its application to immobilization of biomolecules are reported. A thiophene derivative of N-hydroxysuccinimide ester was polymerized with FeCl3 in chloroform and the resulting poly(thiophene) was characterized by nuclear magnetic resonance (NMR), Fourier transform infrared (FT-IR), and gel permeation chromatography (GPC). This polymer reacts with amine-bearing molecules to yield new poly(thiophene) derivatives and the specific interactions at the side groups could be detected. Thus, a self-assembled monolayer (SAM) using the polymer was formed on a gold-coated quartz cell and anti-C-reactive protein (anti-CRP) was immobilized. The binding behavior of CRP on the surface was monitored by use of a surface plasmon resonance (SPR) sensor system. © 2008 Elsevier B.V. All rights reserved. ...
Sinteza sulfimidnih i sulfoksimidnog derivata benzo[b]tiofena | Repozitorij Odjela za kemiju, OsijekSinteza sulfimidnih i sulfoksimidnog derivata benzo[b]tiofena | Repozitorij Odjela za kemiju, Osijek
According to the available literature, up to present date, only one sulfilimine derivative of benzo[b]thiophene is reported and several sulfilimine and sulfoximine derivatives of monocyclic thiophene. Guided by this fact, we have prepared the reported sulfilimine and new sulfoximine derivative of benzo[b]thiophene that was previously unknown. The known synthesis of sulfilimine N- [1λ4-benzo[b]thiophenylidene]-4-methylbenzenesulfonamide (15) was followed in order to oxidise it and to obtain its sulfoximine. After few attempted oxidations, as well as preparations of other analogues of the aforementioned sulfilimine, we have successfully prepared sulfoximine 4-methyl-N- [1-oxo-1H-1λ6benzo[b]thiophen-1-ylidene]benzenesulfonamide by oxidation with H2O2-P2O5 reagent. Sulfoximine 17 is in fact sulfoximine derivative of benzo[b]thiophene. The comparison between the IR spectrum, 1H and 13C NMR spectra of sulfilimine 15 and sulfoximine 17 confirmed this is a new compound with the proposed structure ...
2-(2-Methoxyphenyl)benzo[b]thiophene | C15H12OS - PubChem2-(2-Methoxyphenyl)benzo[b]thiophene | C15H12OS - PubChem
2-(2-Methoxyphenyl)benzo[b]thiophene | C15H12OS | CID 4137516 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Deep Vein Thrombosis Treatment With the Oral Direct Factor Xa Inhibitor Rivaroxaban in Patients Using a Strong CYP 3A4 Inducer ...Deep Vein Thrombosis Treatment With the Oral Direct Factor Xa Inhibitor Rivaroxaban in Patients Using a Strong CYP 3A4 Inducer ...
Prothrombin time (PT) is a global clotting test assessing the extrinsic pathway of the blood coagulation cascade. The test is sensitive for deficiencies of Factors II, V, VII, and X, with sensitivity being best for Factors V, VII, and X and less pronounced for Factor II. The initial read-out of PT is in seconds. The PT slope describes the linear increase of PT for one unit increase in concentration, thus the unit of PT slope is s*(µg/L)^-1. The final population PK/PD model included a fixed slope that was fitted to the data of the 19 patients that were eligible for evaluation. The estimated mean value (fixed/ the same for all patients in this study) is presented for PT slope ...
Deep Vein Thrombosis Treatment With the Oral Direct Factor Xa Inhibitor Rivaroxaban in Patients Using a Strong CYP 3A4 Inducer ...Deep Vein Thrombosis Treatment With the Oral Direct Factor Xa Inhibitor Rivaroxaban in Patients Using a Strong CYP 3A4 Inducer ...
Prothrombin time (PT) is a global clotting test assessing the extrinsic pathway of the blood coagulation cascade. The test is sensitive for deficiencies of Factors II, V, VII, and X, with sensitivity being best for Factors V, VII, and X and less pronounced for Factor II. The initial read-out of PT is in seconds. The PT slope describes the linear increase of PT for one unit increase in concentration, thus the unit of PT slope is s*(µg/L)^-1. The final population PK/PD model included a fixed slope that was fitted to the data of the 19 patients that were eligible for evaluation. The estimated mean value (fixed/ the same for all patients in this study) is presented for PT slope ...
d-orbital participation in bonding in thiophene: Comparison of CNDO/2 and ab initio results<...d-orbital participation in bonding in thiophene: Comparison of CNDO/2 and ab initio results<...
TY - JOUR. T1 - d-orbital participation in bonding in thiophene. T2 - Comparison of CNDO/2 and ab initio results. AU - Náray-Szabó, G.. AU - Peterson, M. R.. PY - 1981/11. Y1 - 1981/11. N2 - We have compared CNDO/2 and ab initio STO-3G calculations for furan and thiophene with and without the inclusion of 3d-orbitals on oxygen and on sulphur. Comparison of localized molecular orbitals indicates that d-orbital participation is over-estimated within the CNDO/2 approximation, although trends are reflected correctly. Enhanced aromaticity of thiophene compared to furan is primarily due to the delocalization of C2C3 π-bonds to the vacant d-orbitals of sulphur. On the other hand, d-orbitals are unimportant in describing σ-bonds. Energies of canonical molecular orbitals, as obtained with the CNDO/2 and ab initio STO-3G* methods and divided into separate σ and π groups, run parallel with each other within both groups.. AB - We have compared CNDO/2 and ab initio STO-3G calculations for furan and ...
Synthesis and reactivity of thiophene palladium and thiophene dipalladium complexes with unsaturated molecules.Synthesis and reactivity of thiophene palladium and thiophene dipalladium complexes with unsaturated molecules.
APPLIED ORGANOMETALLIC CHEMISTRY Appl. Organometal. Chem. 2007; 21: 1041-1053 Published online 8 October 2007 in Wiley InterScience (www.interscience.wiley.com) DOI:10.1002/aoc.1329 Materials, Nanoscience and Catalysis Synthesis and reactivity of thiophene palladium and thiophene dipalladium complexes with unsaturated molecules Abdel-Sattar S. Hamad Elgazwy* Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt Received 9 July 2007; Revised 16 August 2007; Accepted 16 August 2007 • Reactions of 2,5-dibromothiophene, 1, with [Pd2 (dba)3 ] dba [Pd(dba)2 ; dba = dibenzylideneacetone] in the presence of N-donor ligands such as 2,2 -bipyridine (bpy) and 4,4 -di-tert-butyl-2,2 -bipyridine (dtbbpy) give arylpalladium complexes of cis-[2-(5-BrC4 H2 S)PdBrL2 ], 2a, b [L2 = bpy (2a), L2 = dtbbpy (2b)], and cis-cis-L2 PdBr[2,5-(C4 H2 S-)PdBr(L2 )], 3a, b [L2 = bpy (3a), L2 = dtbbpy (3b)]. Treatment of cis complexes 2a, b and 3a, b with CO causes the insertion of ...
Properties of electropolymerized thiophene film 3-substituted with imidazolyl group<...Properties of electropolymerized thiophene film 3-substituted with imidazolyl group<...
TY - GEN. T1 - Properties of electropolymerized thiophene film 3-substituted with imidazolyl group. AU - Kobayashi, Tomohiro. AU - Oyaizu, Kenichi. AU - Yuasa, Makoto. PY - 2005. Y1 - 2005. N2 - Electropolymerizable iron porphyrins have been found to be effective as an electrocatalyst for the detection of a superoxide anion radical. Thiophene 3-substituted with an imidazolyl group was synthesized and electropolymerized. Coordination of the imidazolyl group to various iron complexes provided a novel electrocatalyst for the detection of superoxide. Properties of the electrochemical sensors were evaluated.. AB - Electropolymerizable iron porphyrins have been found to be effective as an electrocatalyst for the detection of a superoxide anion radical. Thiophene 3-substituted with an imidazolyl group was synthesized and electropolymerized. Coordination of the imidazolyl group to various iron complexes provided a novel electrocatalyst for the detection of superoxide. Properties of the electrochemical ...
1-(4-Aminoquinazoline-7-ylmethyl)-4-(6-chlorobenzo[b]thiophene-2-ylsulfonyl)piperazine-2-one | C21H18ClN5O3S2 - PubChem1-(4-Aminoquinazoline-7-ylmethyl)-4-(6-chlorobenzo[b]thiophene-2-ylsulfonyl)piperazine-2-one | C21H18ClN5O3S2 - PubChem
1-(4-Aminoquinazoline-7-ylmethyl)-4-(6-chlorobenzo[b]thiophene-2-ylsulfonyl)piperazine-2-one | C21H18ClN5O3S2 | CID 44384198 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Ethyl-2-[(cyanoacetyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate | VWREthyl-2-[(cyanoacetyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate | VWR
Learn more about Ethyl-2-[(cyanoacetyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate. We enable science by offering product choice, services, process excellence and our people make it happen.
IJMS | Free Full-Text | Origin and Distribution of Thiophenes and Furans in Gas Discharges from Active Volcanoes and Geothermal...IJMS | Free Full-Text | Origin and Distribution of Thiophenes and Furans in Gas Discharges from Active Volcanoes and Geothermal...
The composition of non-methane organic volatile compounds (VOCs) determined in 139 thermal gas discharges from 18 different geothermal and volcanic systems in Italy and Latin America, consists of C2-C20 species pertaining to the alkanes, alkenes, aromatics and O-, S- and N-bearing classes of compounds. Thiophenes and mono-aromatics, especially the methylated species, are strongly enriched in fluids emissions related to hydrothermal systems. Addition of hydrogen sulphide to dienes and electrophilic methylation involving halogenated radicals may be invoked for the formation of these species. On the contrary, the formation of furans, with the only exception of C4H8O, seems to be favoured at oxidizing conditions and relatively high temperatures, although mechanisms similar to those hypothesized for the production of thiophenes can be suggested. Such thermodynamic features are typical of fluid reservoirs feeding high-temperature thermal discharges of volcanoes characterised by strong degassing activity,
N-annulated perylene diimide dimers: the effect of thiophene bridges on physical, electronic, optical, and photovoltaic...N-annulated perylene diimide dimers: the effect of thiophene bridges on physical, electronic, optical, and photovoltaic...
In this work, we report on the synthesis, characterization, and photovoltaic properties of two new N-annulated PDI derivatives connected with one (M1) or two (M2) thiophene bridging units and directly compare to a twisted PDI dimer with no thiophene units (tPDI-Hex). Compounds M1 and M2 were synthesized usin CSC100: Celebrating Canadian Chemistry
ASTM D4735 - 15 Standard Test Method for Determination of Trace Thiophene in Refined Benzene by Gas ChromatographyASTM D4735 - 15 Standard Test Method for Determination of Trace Thiophene in Refined Benzene by Gas Chromatography
D4735 - 15 Standard Test Method for Determination of Trace Thiophene in Refined Benzene by Gas Chromatography , benzene, capillary column, flame photometric detector, gas chromatography, pulsed flame photometric detector, split/splitless injector, thiophene,,
Evaluation of amplified spontaneous emission from photopumped thiophene/phenylene co-oligomers in polycrystalline states | ...Evaluation of amplified spontaneous emission from photopumped thiophene/phenylene co-oligomers in polycrystalline states | ...
We examined the thermal crystallization of deposited films made of 2,5-bis(4-biphenylyl)thiophene (BP1T) and 1,4-bis(5-phenylthiophen-2-yl)benzene (AC5), which are thiophene/phenylene co-oligomers (TPCOs). The deposited films of both BP1T and AC5 showed a microcrystalline phase, and initial microcrystals got larger 10 - 100 times with thermal treatment. Furthermore, we measured the optical properties of microcrystals of BP1T and AC5. At the energy density below the spontaneous amplified emission threshold, it was found that there was a big fluorescent difference between femtosecond laser irradiation and continuous lamp irradiation ...
German Helicopter 1928-1945 by Heinz J Nowarra - Lanzhieron BooksGerman Helicopter 1928-1945 by Heinz J Nowarra - Lanzhieron Books
Schopf and G. ~L--C. ~---SiMe3 Spiro-fused thiophene trimer (a) and spiro-fused thiophene heptamer (see also Sect. 1) (b) [28, 29] Polythiophenes ElectricallyConductive Polymers S ~ ~ 31 S S S n S -- -- n n Polymers of dithieno[3,4-b;3,4-d]thiophene [4, 3~32] Poly(phenanthro[9,10-c]thiophene-2,11-diylidyne) (see also Sect. 3) [-33] Poly(naptho [2,3-c]thiophene-2,9-diyl-2,2-bithiophene-5,5-diyl) [-34] Poly(thieno [3,4-c] thiophene-2,6-diylidynemet hylidene-2,2-bithiophene- 5,5diylmethylidene) [-35] R R Polymers of 4,4-dialkylcyclopenta[-2,1-b;3,4-b]bithiophene n = 1, 3, 4, 6, 8, 16) [,11, 36, 37] s} (o) (R=CnH2n+I, 5 (b) Polymers of 4-(1,3-dithiol-2-ylidene)-4H-cyclopenta[2,1-b;3,4-b]bithiophene (a) and of 7-(1,3-dithiol-2-ylidene)-TH-cyclopenta[1,2-b;3,4-b]bithiophene (b) [38] 32 G. Schopf and G. KoBmehl Table 6. Continued Key words Section in this review Ref. 7 524, 681 577 70 146, 148 615 524 340, 495 333 Contin. Polythiophenes 21 Electrically Conductive Polymers Table 6. Continued ...
clinicaltrialresults.orgclinicaltrialresults.org
EINSTEIN PE: Oral Rivaroxaban Alone for Symptomatic Pulmonary Embolism. -Trial Overview by Dr. Harry Roger Buller (ACC 2012). MAGELLAN: Rivaroxaban Compared with Enoxaparin for the Prevention of Venous Thromboembolism in Acutely Ill Medical Patients. -Trial Overview by Dr. Alexander Cohen (ACC 2011). ROCKET-AF: Stroke Prevention Using the Oral Direct Factor Xa Inhibitor Rivaroxaban Compared with Warfarin in Patients with Nonvalvular Atrial Fibrillation. -Trial Overview by Dr. Kenneth Mahaffey and Dr. Keith Fox (AHA 2010). ...
Biblioteca Digital do IPB: Antifungal activity of diarylamines in the benzo[b]thiophene series and SARBiblioteca Digital do IPB: Antifungal activity of diarylamines in the benzo[b]thiophene series and SAR
Several diarylamines la-f and 2 were prepared using palladium-catalyzed C-N coupling of electron deficient or rich benzo[b]thienylbromides with aromatic amines. Using 2-aminopyridine a one pot C-N coupling and intermolecular cyclization involving the nitrogen of the pyridine, with lost of ethanol, occurred giving compound 3 ...
Synthesis and characterization of a new class of thiophene containing by Javier Santos-Perez"Synthesis and characterization of a new class of thiophene containing " by Javier Santos-Perez
Photoresponsive molecules have a broad range of potential applications, for example in optical, energy, and biomedical technologies. Fluorophores and second order nonlinear optical (NLO) chromophores are photoresponsive molecules used as signaling materials and frequency doublers or electro-optical modulators, respectively. The research presented here describes the synthesis, characterization, and potential applications of a group of highly fluorescent molecules and NLO chromophores containing benzene, imidazole and thiophene rings. Methyl, methoxy, and dimethylamino groups were used as electron donor groups while formyl and nitro groups were used as electron acceptors. The fluorescence properties of a series of dyes containing donor groups and a formyl group attached to a thiophenyl ring were investigated. X-ray structural determination revealed a steric crowding, which causes a molecular twist in the ground state. The fluorescence quantum yield for these fluorophores was found in the range of0.004-1.0
Duloxetine hydrochloride / duloxetine hydrochloride FDA New drug application 090745 global drug patent coverage, generic...Duloxetine hydrochloride / duloxetine hydrochloride FDA New drug application 090745 global drug patent coverage, generic...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Duloxetine hydrochloride / duloxetine hydrochloride NDA 202336 international drug patent coverage, generic alternatives and...Duloxetine hydrochloride / duloxetine hydrochloride NDA 202336 international drug patent coverage, generic alternatives and...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Plus itPlus it
NSC 652287 is a representative of a novel class of thiophene derivatives discovered in the NCI Anticancer Drug Screen for their activity against the subpanel of cell lines derived from renal cancer, a disease for which present chemotherapy has limited activity. The present study shows that thiophene NSC 652287 is a potent inducer of apoptosis at submicromolar concentrations. Apoptosis was associated with p53 elevation and decrease of p21WAF1 protein levels in A498 cells. By contrast, lower NSC 652287 concentrations induced elevation of both p53 and p21WAF1 and cell cycle arrest (Fig. 3 and Table 2). A decrease of p21WAF1 in spite of p53 elevation at NSC 652287 concentrations that induced apoptosis was probably due to p21WAF1 degradation during apoptosis. p21WAF1 is indeed a substrate for caspases (Gervais et al., 1998).. Although A498 cells have wild-type p53 and are very sensitive to NSC 652287, two of the most resistant kidney cell lines of the NCI Anticancer Drug Screen, ACHN and UO-31, also ...
Design and synthesis of sulfur cross-linked 1,3,4-oxadiazole-nitro(furan/thiophene)-propenones as dual inhibitors of...Design and synthesis of sulfur cross-linked 1,3,4-oxadiazole-nitro(furan/thiophene)-propenones as dual inhibitors of...
Abstract A series of 3-[5-nitro(furan/thiophene)-2-yl]-1-aryl-3-(5-aryl-1,3,4-oxadiazol-2-ylthio)prop-2-en-1-one derivatives was synthesized and studied with the aim of developing dual inhibitors of...
Regioselective synthesis of thiophene fused sultam derivatives via iodocyclization approach and their application towards...Regioselective synthesis of thiophene fused sultam derivatives via iodocyclization approach and their application towards...
TY - JOUR. T1 - Regioselective synthesis of thiophene fused sultam derivatives via iodocyclization approach and their application towards triazole linker. AU - Barange, Deepak Kumar. AU - Kavala, Veerababurao. AU - Kuo, Chun Wei. AU - Wang, Cheng Chuan. AU - Rajawinslin, R. R.. AU - Donala, Janreddy. AU - Yao, Ching Fa. PY - 2014/10/14. Y1 - 2014/10/14. N2 - An efficient regioselective synthesis of 4-iodo-2,3-disubstituted-2H-thieno[3,2-e][1,2]thiazine-1,1-dioxide derivatives via iodocyclization approach using iodine under mild reaction condition described herein. This coupling-iodocyclization strategy tolerated a variety of functional groups such as alkyl, cycloalkyl, phenyl producing the six-membered heterocyclic ring selectively. The resulting 4-iodo-2,3-disubstituted-2H-thieno[3,2-e][1,2]thiazine-1,1-dioxide was coupled with a variety of boronic acids (Suzuki coupling) and activated alkenes (Heck coupling). The iodo group was utilized for Sonogashira coupling followed by efficient ...
1E)-?1,1(3H,3H)-Bi[benzo[c]thiophene]-3,3-dione (CAS No. 23667-32-5) Suppliers @ ChemicalRegister.com1E)-?1,1'(3H,3'H)-Bi[benzo[c]thiophene]-3,3'-dione (CAS No. 23667-32-5) Suppliers @ ChemicalRegister.com
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for (1E)-?1,1(3H,3H)-Bi[benzo[c]thiophene]-3,3-dione (CAS No. 23667-32-5)
Pi Chemicals System - PI-41981 3,4-(2,2-Dimethylpropylenedioxy)thiophene (255901-50-9)Pi Chemicals System - PI-41981 3,4-(2,2-Dimethylpropylenedioxy)thiophene (255901-50-9)
Provide fine chemicals, building blocks and pharmaceutical intermediates. PI-41981 3,4-(2,2-Dimethylpropylenedioxy)thiophene (255901-50-9) Synonym: 3,3-Dimethyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine Molecular Formula: C9H12O2S Weight: 184.25 CAS No: 255901-50-9 Appearance: Purity:95.0% FM Point:42.0 to 46.0 deg-C Order online from laboratory chemical supplier and distributor.
N-cyclopropylmethyl-7-(1-hydroxy-1-methyl-3-(2-thiophene)propyl)-6,14-endoethanotetrahydrooripavine Summary Report |...N-cyclopropylmethyl-7-(1-hydroxy-1-methyl-3-(2-thiophene)propyl)-6,14-endoethanotetrahydrooripavine Summary Report |...
N-cyclopropylmethyl-7-(1-hydroxy-1-methyl-3-(2-thiophene)propyl)-6,14-endoethanotetrahydrooripavine: has analgesic activity; structure in first source
Thiophene,3-bromo-4-ethoxy-(9ci) - Alfa ChemistryThiophene,3-bromo-4-ethoxy-(9ci) - Alfa Chemistry
Thiophene,3-bromo-4-ethoxy-(9ci)/ACM425426864 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Trabalho 29 - Thais Matsue Uekane - VALIDATION OF A METHOD FOR THE ANALYSIS OF 2-FURFURYLTHIOL, THIOPHENE AND DIMETHYL...Trabalho 29 - Thais Matsue Uekane - VALIDATION OF A METHOD FOR THE ANALYSIS OF 2-FURFURYLTHIOL, THIOPHENE AND DIMETHYL...
VALIDATION OF A METHOD FOR THE ANALYSIS OF 2-FURFURYLTHIOL, THIOPHENE AND DIMETHYL DISULFIDE BY GAS CHROMATOGRAPHY COUPLED WITH MASS SPECTROMETRY (GC-QMS) UEKANE, T.M.1*, ROCHA-LEÃO, M.H.M.2, REZENDE, C.M.1 1 Universidade Federal do Rio de Janeiro, Instituto de Química, Cidade Universitária, CT, Bloco A, CEP 21941-909, Rio de Janeiro - RJ, Brazil. 2 Universidade Federal do Rio…
The electronic and geometric structures of neutral and potassium-doped poly[3-(4-octylphenyl)thiophene] studied by...The electronic and geometric structures of neutral and potassium-doped poly[3-(4-octylphenyl)thiophene] studied by...
The electronic and geometric structures of poly [3-(4-octylphenyl)thiophene] have been studied by X-ray and ultraviolet photoelectron spectroscopy (XPS and UPS, respectively). Thermochromic effects, and new charge induced states generated by potassium doping, have been observed by direct UPS measurements. The experimental results are in very good agreement with the results of theoretical quantum chemical calculations performed with the Austin Model 1 semi-empirical model and the valence-effective Hamiltonian pseudo-potential model.. ...
Infrared laser multiple photon dissociation of thiophene in gas phase | SpringerLinkInfrared laser multiple photon dissociation of thiophene in gas phase | SpringerLink
Infrared laser multiple photon excitation/dissociation of Thiophene (Th) was studied as a function of Th pressure, laser pulse energy, pulse duration and added buffer gas. While the excitation...
2-Amino-2-(2-chlorophenyl)acetic acid | 88744-36-9,141196-64-7 | Carbosynth Product2-Amino-2-(2-chlorophenyl)acetic acid | 88744-36-9,141196-64-7 | Carbosynth Product
Buy high quality 2-Amino-2-(2-chlorophenyl)acetic acid 88744-36-9,141196-64-7 from Carbosynth, your source for Carbohydrates, Nucleosides and Fine Chemicals.
poly[4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b;4,5-b]dithiophene-2,6-diyl-alt-(4-(2-ethylhexyl)-3-fluorothieno[3,4-b]...poly[4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b;4,5-b']dithiophene-2,6-diyl-alt-(4-(2-ethylhexyl)-3-fluorothieno[3,4-b]...
Page contains details about poly[4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b;4,5-b]dithiophene-2,6-diyl-alt-(4-(2-ethylhexyl)-3-fluorothieno[3,4-b]-thiophene-)-2-carboxylate-2-6-diyl)]:poly[[N,N`-bis(2-octyldodecyl)-napthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,5`-(2,2`-bithiophene)]-based polymer solar cell . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
2-(1h-pyrrol-1-yl)thiophene-3-carboxylic acid - Alfa Chemistry2-(1h-pyrrol-1-yl)thiophene-3-carboxylic acid - Alfa Chemistry
2-(1h-pyrrol-1-yl)thiophene-3-carboxylic acid/ACM79242765 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
ChemIDplus - 34861-51-3 - OTFQKNIBEITZQS-UHFFFAOYSA-N - 6,8-Dichloro-alpha-((dibutylamino)methyl)naphtho(2,1-b)thiophene-4...ChemIDplus - 34861-51-3 - OTFQKNIBEITZQS-UHFFFAOYSA-N - 6,8-Dichloro-alpha-((dibutylamino)methyl)naphtho(2,1-b)thiophene-4...
34861-51-3 - OTFQKNIBEITZQS-UHFFFAOYSA-N - 6,8-Dichloro-alpha-((dibutylamino)methyl)naphtho(2,1-b)thiophene-4-methanol - Similar structures search, synonyms, formulas, resource links, and other chemical information.
1-thiophene-2-carbonyl-piperidine-4-carboxylic-acid | VWR1-thiophene-2-carbonyl-piperidine-4-carboxylic-acid | VWR
Learn more about 1-thiophene-2-carbonyl-piperidine-4-carboxylic-acid. We enable science by offering product choice, services, process excellence and our people make it happen.
Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and...Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and...
Proteins that deposit as amyloid in tissues throughout the body can be the cause or consequence of a large number of diseases. Among these we find neurodegenerative diseases such as Alzheimers and Parkinsons disease afflicting primarily the central nervous system, and systemic amyloidosis where serum amyloid A, transthyretin and IgG light chains deposit as amyloid in liver, carpal tunnel, spleen, kidney, heart, and other peripheral tissues. Amyloid has been known and studied for more than a century, often using amyloid specific dyes such as Congo red and Thioflavin T (ThT) or Thioflavin (ThS). In this paper, we present heptamer-formyl thiophene acetic acid (hFTAA) as an example of recently developed complements to these dyes called luminescent conjugated oligothiophenes (LCOs). hFTAA is easy to use and is compatible with co-staining in immunofluorescence or with other cellular markers. Extensive research has proven that hFTAA detects a wider range of disease associated protein aggregates than ...
1c5u - Proteopedia, life in 3D1c5u - Proteopedia, life in 3D
BACKGROUND: Urokinase-type plasminogen activator (uPA) is a protease associated with tumor metastasis and invasion. Inhibitors of uPA may have potential as drugs for prostate, breast and other cancers. Therapeutically useful inhibitors must be selective for uPA and not appreciably inhibit the related, and structurally and functionally similar enzyme, tissue-type plasminogen activator (tPA), involved in the vital blood-clotting cascade. RESULTS: We produced mutagenically deglycosylated low molecular weight uPA and determined the crystal structure of its complex with 4-iodobenzo[b]thiophene 2-carboxamidine (K(i) = 0.21 +/- 0.02 microM). To probe the structural determinants of the affinity and selectivity of this inhibitor for uPA we also determined the structures of its trypsin and thrombin complexes, of apo-trypsin, apo-thrombin and apo-factor Xa, and of uPA, trypsin and thrombin bound by compounds that are less effective uPA inhibitors, benzo[b]thiophene-2-carboxamidine, ...
1c5s - Proteopedia, life in 3D1c5s - Proteopedia, life in 3D
BACKGROUND: Urokinase-type plasminogen activator (uPA) is a protease associated with tumor metastasis and invasion. Inhibitors of uPA may have potential as drugs for prostate, breast and other cancers. Therapeutically useful inhibitors must be selective for uPA and not appreciably inhibit the related, and structurally and functionally similar enzyme, tissue-type plasminogen activator (tPA), involved in the vital blood-clotting cascade. RESULTS: We produced mutagenically deglycosylated low molecular weight uPA and determined the crystal structure of its complex with 4-iodobenzo[b]thiophene 2-carboxamidine (K(i) = 0.21 +/- 0.02 microM). To probe the structural determinants of the affinity and selectivity of this inhibitor for uPA we also determined the structures of its trypsin and thrombin complexes, of apo-trypsin, apo-thrombin and apo-factor Xa, and of uPA, trypsin and thrombin bound by compounds that are less effective uPA inhibitors, benzo[b]thiophene-2-carboxamidine, ...
Most recent papers with the keyword VTE DVT anticoagulation treatment duration | Read by QxMDMost recent papers with the keyword VTE DVT anticoagulation treatment duration | Read by QxMD
Venous thromboembolism (VTE) is associated with numerous complications and high mortality rates. Patients with cancer are at high risk of developing cancer-associated thrombosis (CAT), and VTE recurrence is common. Evidence supporting use of non-vitamin K antagonist (VKA) oral anticoagulants (NOACs) in patients with cancer is lacking - direct comparisons between NOACs and low-molecular-weight heparin (LMWH) are needed, along with patient-reported outcomes. Cancer Associated thrombosis - expLoring soLutions for patients through Treatment and Prevention with RivarOxaban (CALLISTO) is an international research programme exploring the potential of the direct, oral factor Xa inhibitor rivaroxaban for the prevention and treatment of CAT, supplementing existing data from EINSTEIN DVT and EINSTEIN PE ...
Batimastat (BB-94) | ≥99%(HPLC) | Selleck | MMP inhibitor ...Batimastat (BB-94) | ≥99%(HPLC) | Selleck | MMP inhibitor ...
Effect of the broad spectrum hydroxamate inhibitors batimastat and ilomastat on a disintegrin and metalloproteinase with thombospondin type 1 motifs (ADAMTS) 13 and ADAMTS15. (A) While batimastat is a good inhibitor against ADAMTS15, ilomastat has no ability to inhibit the enzyme. ADAMTS15 (20 nM) was pre-incubated with two doses (300 nM or 3 µM) of batimastat and ilomastat prior to the addition of aggrecan substrate G1-IGD-G2. The inhibitory effect of batimastat can be clearly discerned from the undigested 130 kDa G1-IGD-G2 bands. (B) Calculation of the Kiapp value of batimastat by densitometric analysis of the undigested G1-IGD-G2 bands on a 12% SDS-PAGE.. Biomed Rep, 2016, 4(1):73-78. . Batimastat (BB-94) purchased from Selleck. ...
RITA (NSC 652287) | p53 activator | Buy RITA (NSC 652287) from Supplier AdooQ®RITA (NSC 652287) | p53 activator | Buy RITA (NSC 652287) from Supplier AdooQ®
RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
Alfa Aesar™ Potassium thiophene-3-trifluoroborate, 97% 250mg Alfa Aesar™ Potassium thiophene-3-trifluoroborate, 97%Alfa Aesar™ Potassium thiophene-3-trifluoroborate, 97% 250mg Alfa Aesar™ Potassium thiophene-3-trifluoroborate, 97%
Alfa Aesar™ Potassium thiophene-3-trifluoroborate, 97% 250mg Alfa Aesar™ Potassium thiophene-3-trifluoroborate, 97% Inorganic Potassium Compounds
Approved Drugs Show Similar Efficacy for Diabetic Peripheral Neuropathic PainApproved Drugs Show Similar Efficacy for Diabetic Peripheral Neuropathic Pain
Duloxetine, pregabalin, and gabapentin offer similar efficacy for patients with diabetic peripheral neuropathic pain, according to a new report. Few direc
5-(2-Methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-thiophene-2-carboxylic acid [(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl...5-(2-Methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-thiophene-2-carboxylic acid [(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl...
Read about the chemical and physical properties of 5-(2-Methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-thiophene-2-carboxylic acid [(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-amide. Get 5-(2-Methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-thiophene-2-carboxylic acid [(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-amide molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
MOHAMMED A ASSIRIMOHAMMED A ASSIRI
In order to tune the optoelectronic and charge transfer properties of 4,6-di(thiophen-2-yl)pyrimidine (1), some new compounds were designed, i.e., 4,6-bis(benzo[$b$]thiophen-2-yl)pyrimidine (2), 4,6-bis(naphtho[2,3-b]thiophen-2-yl)pyrimidine (3), 4,6-bis(anthra[2,3-b]thiophen-2-yl)pyrimidine (4), 4,6-bis(tetraceno[2,3-$b$]thiophen-2-yl)pyrimidine (5) and 4,6-bis(pentaceno[2,3-$b$]thiophen-2-yl)pyrimidine (6). Compounds 2-6 were designed by assimilation of benzene, naphthalene, anthracene, tetracene and pentacene, respectively at both ends of compound 1. Integration of oligocene end cores reduces the energy gap resulting in a red shift in the absorption and fluorescence emission spectra. The legible intra-molecularcharge transfer is significant from electron-rich moieties to the electron-deficient core (pyrimidine). The elongation of $\pi$-conjugation led to escalate the electron affinity, lower the ionization potential and hole reorganization energy. The hole reorganization energies of compounds ...
Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised...Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised...
Our results demonstrate that strontium ranelate has structure-modifying activity in patients with knee osteoarthritis, with significantly smaller degradations in JSW over the study (p,0.001 for 1 g/day and p=0.018 for 2 g/day vs placebo). There were fewer patients with radiographical and radioclinical progression of osteoarthritis in the treatment groups. Additionally to this structural effect, symptomatic improvement was observed, with a significant impact on WOMAC total score and pain subscore (p=0.045 and p=0.028, respectively), and a trend towards improvement in global knee pain (p=0.065) at 2 g/day, but not 1 g/day. The safety profile of strontium ranelate was satisfactory, in line with knowledge of this agent.20 ,21 There was a slight mean increase in creatine phosphokinase in the treated groups as previously described for strontium ranelate.20 Pooled analysis in osteoporotic patients treated with strontium ranelate showed that increases were mainly mild, transient and reversible22; they ...
北京大学医学部机构知识库(IR@PKUHSC): Safety, pharmacokinetics and pharmacodynamics of single/multiple doses of the oral, direct Factor Xa...北京大学医学部机构知识库([email protected]): Safety, pharmacokinetics and pharmacodynamics of single/multiple doses of the oral, direct Factor Xa...
center dot Rivaroxaban is an oral, direct Factor Xa inhibitor in advanced clinical development for the prevention and treatment of thromboembolic disorders.. center dot In single- and multiple-dose Phase I studies in White subjects, rivaroxaban was safe and demonstrated predictable, dose-dependent pharmacokinetics and pharmacodynamics.. WHAT THIS STUDY ADDS. center dot The Phase III programme with rivaroxaban is being conducted worldwide.. center dot Therefore, it is necessary to determine whether the pharmacokinetics, pharmacodynamics and tolerability of rivaroxaban are altered in patients of different ethnic origins.. center dot Dose-escalation studies were conducted to determine the safety, pharmacokinetics and pharmacodynamics of single and multiple doses of rivaroxaban in healthy Chinese subjects.. AIMS. To investigate the safety, pharmacokinetics and pharmacodynamics of rivaroxaban, an oral, direct Factor Xa (FXa) inhibitor, in healthy, male Chinese subjects.. METHODS. Two randomized, ...
IJMS | Free Full-Text | A Facile and Convenient Synthesis of some Novel Hydrazones, Schiffs Base and Pyrazoles Incorporating...IJMS | Free Full-Text | A Facile and Convenient Synthesis of some Novel Hydrazones, Schiff's Base and Pyrazoles Incorporating...
A facile and convenient synthesis of some novel hydrazones, schiffs base and pyrazoles from thieno[2,3-b]thiophene derivatives 1 have been achieved in high yields assisted by microwave and classical methods. The structures of all the title compounds have been elucidated by elemental analysis, IR, MS, 1H-NMR and 13C-NMR. Generally, these findings represent a new class of sulfur and nitrogen moieties that should also be of interest as new materials.
Nonvitamin K antagonist oral anticoagulant activity: challenges in measurement and reversal | Critical Care | Full TextNonvitamin K antagonist oral anticoagulant activity: challenges in measurement and reversal | Critical Care | Full Text
Four nonvitamin K antagonist oral anticoagulants (NOACs) are approved for the prevention of stroke in patients with nonvalvular atrial fibrillation and for the treatment of venous thromboembolism. These include the direct thrombin inhibitor dabigatran and the direct factor Xa inhibitors rivaroxaban, apixaban, and edoxaban. Bleeding is a complication for all anticoagulants and concerns regarding bleeding risk and the suitability of effective reversal strategies may be a barrier to their prescription. Despite the reduced risk of bleeding compared with vitamin K antagonists, questions persist regarding the management of bleeding related to NOAC use. To date, although a number of assays are responsive to NOACs, no single routine laboratory test has been identified to accurately measure the clinical anticoagulation state of patients on NOACs or established as a reliable predictor of bleeding risk. In addition, the establishment of a reliable human bleeding model to test novel inhibitors of the coagulation
Idarucizumab: The Antidote for Reversal of Dabigatran RadcliffeCardiologyIdarucizumab: The Antidote for Reversal of Dabigatran RadcliffeCardiology
Four non-vitamin K antagonist oral anticoagulants (NOACs), including the direct thrombin inhibitor dabigatran and the direct factor Xa inhibitors rivaroxaban, apixaban, and edoxaban, are currently licensed as alternatives to heparins and vitamin K antagonists for the prevention and treatment of venous thromboembolism and for the prevention of stroke in patients with nonvalvular atrial fibrillation. Dabigatran is the only NOAC that inhibits thrombin; the others inhibit factor Xa. All of the NOACs are at least as effective as vitamin K antagonists for the prevention of stroke in patients with atrial fibrillation and for the treatment of venous thromboembolism, and they are associated with less life-threatening bleeding, in particular less intracranial hemorrhage.1,2 Nonetheless, serious bleeding can occur with NOACs. In addition, patients taking NOACs may sustain trauma and may require urgent surgery or interventions. Consequently, the availability of specific reversal agents for NOACs could ...
KLUEDO | SuchenKLUEDO | Suchen
Acidic zeolites like H-Y, H-ZSM-5, H-MCM-22 and H-MOR zeolites were found to be the selective adsorbents for the removal of thiophene from toluene or n-heptane as solvent. The competitive adsorption of toluene is found to influence the adsorption capacity for thiophene and is more predominant when high-alumina zeolites are used as adsorbents. This behaviour is also reflected by the results of the adsorption of thiophene on H-ZSM-5 zeolites with varied nSi/nAl ratios (viz. 13, 19 and 36) from toluene and n-heptane as solvents, respectively. UV-Vis spectroscopic results show that the oligomerization of thiophene leads to the formation of dimers and trimers on these zeolites. The oligomerization in acid zeolites is regarded to be dependent on the geometry of the pore system of the zeolites. The sulphur-containing compounds with more than one ring viz. benzothiophene, which are also present in substantial amounts in certain hydrocarbon fractions, are not adsorbed on H-ZSM-5 zeolites. This is ...
Electropolymerization of thiophene having porphyrin group and its application to superoxide sensor<...Electropolymerization of thiophene having porphyrin group and its application to superoxide sensor<...
TY - GEN. T1 - Electropolymerization of thiophene having porphyrin group and its application to superoxide sensor. AU - Hoshino, Manabu. AU - Murata, Hidenori. AU - Oyaizu, Kenichi. AU - Yuasa, Makoto. PY - 2006. Y1 - 2006. N2 - Iron 5-(3-thienyl)-10,15,20-triethylporphyrin was electropolymerized in supercritical carbon dioxide (scCO2) to yield the corresponding conductive polymer film. The film was analyzed by scanning electron microscopy, laser microscopy and AFM. It was revealed that the thiophene-porphyrin film synthesized in scCO2 was more dense and smoother than those synthesized in dichloromethane. The electrocatalyst was applied to a superoxide anion radical sensor, and its detection sensitivity was drastically increased.. AB - Iron 5-(3-thienyl)-10,15,20-triethylporphyrin was electropolymerized in supercritical carbon dioxide (scCO2) to yield the corresponding conductive polymer film. The film was analyzed by scanning electron microscopy, laser microscopy and AFM. It was revealed that ...
Chemistry of Heterocyclic CompoundsChemistry of Heterocyclic Compounds
Advances in Heterocyclic Chemistry - 1st Edition - ISBN: 9780124201606, 9780124202092. Paal-Knorr Reaction in the Synthesis of Heterocyclic Compounds.. Thiophene and Its Derivatives, Part 2 (The Chemistry of ... Buy Thiophene and Its Derivatives, Part 2 (The Chemistry of Heterocyclic Compounds, Vol. 44) on Amazon.com ✓ FREE SHIPPING on qualified orders. Chemistry of Heterocyclic Compounds Profession. Heterocyclic compounds are presumably the largest class of organic compounds, obtaining great diversity in chemical and physical properties. Thus Chemistry of Heterocyclic Compounds - CRC Press Book Dec 22, 2014 This book discusses the structure, synthesis, and reactivity of heterocyclic compounds. It covers nomenclature, conformational aspects, Heterocyclic Chemistry - MSU Chemistry Devising a systematic nomenclature system for heterocyclic compounds presented a formidable challenge, which has not been uniformly concluded. Thiophene and Its Derivatives, Part 2 (The Chemistry of ... Buy Thiophene ...
Patent US6608323 - n-type thiophene semiconductors - Google PatentsPatent US6608323 - n-type thiophene semiconductors - Google Patents
The new fluorocarbon-functionalized polythiophenes, in particular, α,ω-diperfluorohexylsexithiophene DFH-6T (1) can be straightforwardly prepared in high yield and purified by gradient sublimation. Introduction of perfluorocarbon chains on the thiophene core affords enhanced thermal stability and volatility, and increased electron affinity versus the fluorine-free analog 2. Evaporated films of 1, for example, behave as n-type semiconductors, and can be used to fabricate thin film transistors with FET mobilities on the order of ˜0.01 cm2/Vs-some of the highest reported to date for n-type organic semiconductors.
Density functional theory study of neutral and oxidized thiophene oligomers (Journal Article) | SciTech ConnectDensity functional theory study of neutral and oxidized thiophene oligomers (Journal Article) | SciTech Connect
The effect of oxidation on the energetics and structure of thiophene (Th) oligomers is studied with density functional theory at the B3PW91/6-311++G(d,p) level. Neutral n-Th oligomers (2 , n , 13) are gently curved planar chains. Ionization potential and electron affinity results show that n-Th oligomers are easier to be oxidized as their chain length increases. Oxidation states +2, +4, +6, and +8 are energetically stable in 12-Th. Upon oxidation the conjugated backbone of 12-Th switches from extended benzenoid phase to quinoid phase localized on groups of monomers regularly spaced along the chain. Oxidized states +2, +4, +6, and +8 of 12-Th display two +1e localized at the ends of their chains only because of the finite size of the chains. In 12-Th this end-effect extends over the two terminal monomers forming a positive-negative charge duet. This peculiar charge localization makes n-Th oligomers different from other conducting polymers with similar structure, such as polypyrrole. The spectrum ...
Photochemical generation of radical cations of dithienothiophenes, condensed thiophene trimers, studied by laser flash...Photochemical generation of radical cations of dithienothiophenes, condensed thiophene trimers, studied by laser flash...
TY - JOUR. T1 - Photochemical generation of radical cations of dithienothiophenes, condensed thiophene trimers, studied by laser flash photolysis. AU - Fujitsuka, Mamoru. AU - Sato, Tadatake. AU - Shimidzu, Takeo. AU - Watanabe, Akira. AU - Ito, Osamu. PY - 1997/2/6. Y1 - 1997/2/6. N2 - Photoinduced electron-transfer reactions between dithienothiophene (DTT) and the electron acceptors, p-dinitrobenzene (DNB) and CCl4, have been investigated using nanosecond laser flash photolysis and time-resolved fluoresence spectroscopy. Generation of the radical cations of DTTs and radical anion of DNB in acetonitrile solution was confirmed by transient absorption spectra in the visible and near-IR regions. Observed transient absorption bands corresponded to those of radical ions generated by γ irradiation in a frozen matrix. Electron transfer occurred both from the singlet and triplet excited states of DTT to DNB at the diffusion-controlled rate, ∼1010 M-1 s-1. When CCl4 was used as an acceptor, electron ...
Synthesis, properties and applications of chalcogen-containing antioxidants - OpenThesisSynthesis, properties and applications of chalcogen-containing antioxidants - OpenThesis
In the first part, the preparation and properties of chalcogen-containing vitamin E analogues are described. The sulfur compound 3,3,4,6,7-pentamethyl-2,3-dihydrobenzo[b]thiophene-5-ol was prepared by two different routes using ionic and radical chemistry. Interesting rearrangements were observed in the two synthetic pathways. A new methodology for the synthesis of dihydroselenophene and dihydrotellurophene derivatives is described. In the preparation of the vitamin E analogues 2,3-dihydrobenzo[b]selenophene-5-ol and 2,3-dihydrobenzo[b]tellurophene-5-ol a tellurium-mediated tandem SRN1/SHi sequence was suggested to be operative. 2,3-Dihydrobenzo[b]thiophene-5-ol and the vitamin E-like selenide 2-methyl-2-(4,8,12-trimethyl-tridecyl)-selenochroman-6-ol were prepared via intramolecular homolytic substitution at sulfur and selenium, respectively. The first rate constant for intramolecular homolytic substitution at tellurium is also reported (5x108 s-1 at 25 °C). The antioxidant profile for ...
Haemonetics Select PublicationsHaemonetics Select Publications
Context: The clinical introduction of new oral anticoagulants (NOACs) has stimulated the development of tests to quantify the effects of these drugs and manage complications associated with their use. Until recently, the only treatment choices for the prevention of venous thromboembolism in orthopedic surgical patients, as well as for stroke and systemic embolism in patients with atrial fibrillation, were vitamin K antagonists, antiplatelet drugs, and unfractionated and low-molecular-weight heparins. With the approval of NOACs, treatment options and consequent diagnostic challenges have expanded. Objective: To study the utility of thromboelastography (TEG) in monitoring and differentiating between 2 currently approved classes of NOACs, direct thrombin inhibitors (dabigatran) and factor Xa inhibitors (rivaroxaban and apixaban). Design: Blood samples from healthy volunteers were spiked with each NOAC in both the presence and absence of ecarin, and the effects on TEG were evaluated. Results: Both ...
4-(chloromethyl)-2-thiophen-2-yl-1,3-thiazole 54679-16-2 Chemical Properties Physical Properties4-(chloromethyl)-2-thiophen-2-yl-1,3-thiazole 54679-16-2 Chemical Properties Physical Properties
4-(chloromethyl)-2-thiophen-2-yl-1,3-thiazole chemical properties, What are the chemical properties of 4-(chloromethyl)-2-thiophen-2-yl-1,3-thiazole 54679-16-2, What are the physical properties of 4-(chloromethyl)-2-thiophen-2-yl-1,3-thiazole ect.
2-(4-methoxyphenyl)-5-thiophen-2-ylthiophene 106925-79-5 H-NMR | C-NMR Spectral Analysis NMR Spectrum2-(4-methoxyphenyl)-5-thiophen-2-ylthiophene 106925-79-5 H-NMR | C-NMR Spectral Analysis NMR Spectrum
2-(4-methoxyphenyl)-5-thiophen-2-ylthiophene 106925-79-5 NMR spectrum, 2-(4-methoxyphenyl)-5-thiophen-2-ylthiophene H-NMR spectral analysis, 2-(4-methoxyphenyl)-5-thiophen-2-ylthiophene C-NMR spectral analysis ect.
861965-63-1, thiophen-3-amine oxalate, CAS No 861965-63-1 thiophen-3-amine oxalate id861965-63-1, thiophen-3-amine oxalate, CAS No 861965-63-1 thiophen-3-amine oxalate id
CAS NO:861965-63-1; Chemical name:thiophen-3-amine oxalate ; physical and chemical property of 861965-63-1, thiophen-3-amine oxalate is provided by ChemNet.com
Sulfur Removal from Dibenzothiophene by Newly Isolated Paenibacillus validus Strain PD2 and Process Optimization in Aqueous and...Sulfur Removal from Dibenzothiophene by Newly Isolated Paenibacillus validus Strain PD2 and Process Optimization in Aqueous and...
Ansari F., P. Prayuenyong and I.E. Tothill. 2007. Biodesulfurization of dibenzothiophene by Shewanella putrefaciens. J. Bio.l Phys. Chem. 7:75-78. [Link]. Ardakani M.R., A. Aminsefat, B. Rasekh, F. Yazdiyan, B. Zargar, M. Zarei and H. Najafzadeh. 2010. Biodesulfurization of dibenzothiophene by a newly isolated Stenotrophomonas maltophila strain Kho1. WASJ. 10:272-2778. [Link]. Bahuguna A., M.K. Lily, A. Munjal, R.N. Singh and K. Dangwal. 2011. Desulfurization of dibenzothiophene (DBT) by a novel strain Lysinibacillus sphaericus DMT-7 isolated from diesel contaminated soil. J. Env. Sci. 23:975-982. [PubMED]. Berg J.M., J. Tymoczko and L. Stryer. 2007. Biochemistry. Freeman and company, New York.. Borgne S.L. and R. Quintero. 2003. Biotechnological processes for the refining of petroleum. Fuel process technol. 81:155-169. [Link]. Bustos-Jaimes I., G. Amador, G. Castorena and S. Le Borgne. 2003. Genotypic characterization of sulfur-oxidative desulfurizing bacterial strains isolated from Mexican ...
CAS # 51527-19-6, 2-(5-Chloro-3-methylbenzo[b]thiophen-2-yl)acetic acidCAS # 51527-19-6, 2-(5-Chloro-3-methylbenzo[b]thiophen-2-yl)acetic acid
chemBlink provides information about CAS # 51527-19-6, 2-(5-Chloro-3-methylbenzo[b]thiophen-2-yl)acetic acid, molecular formula: C11H9ClO2S.
Pesquisa | Portal Regional da BVSPesquisa | Portal Regional da BVS
BACKGROUND AND OBJECTIVES: Strontium ranelate is a medication indicated for the treatment of osteoporosis that presents concomitant anti-resorptive and osteoanabolic dual biological activity. However, the effects of strontium ranelate on alveolar bone have been poorly explored. Furthermore, to date, there are no data on the effects of this medication on alveolar bone loss (BL) during conditions of estrogen deficiency. Therefore, the aim of this study was to evaluate the effects of strontium ranelate on ligature-induced periodontitis in estrogen-deficient and estrogen-sufficient rats. METHODS: Ninety-six rats were assigned to one of the following groups: sham-surgery + water (estrogen-sufficient; n = 24); ovariectomy + water (estrogen-deficient; n = 24), sham-surgery + strontium ranelate (ranelate/estrogen-sufficient; n = 24) and; ovariectomy + strontium ranelate (ranelate/estrogen-deficient; n = 24). The rats received strontium ranelate or water from the 14th day after ovariectomy until the end ...
Selectivity of modified CeO<sub>2</sub>-based adsorbents for adsorptive desulfurization of hydrocarbon...Selectivity of modified CeO<sub>2</sub>-based adsorbents for adsorptive desulfurization of hydrocarbon...
TY - GEN. T1 - Selectivity of modified CeO2-based adsorbents for adsorptive desulfurization of hydrocarbon fuels. AU - Watanabe, Shingo. AU - Xiaoliang, Ma. AU - Song, Chunshan. PY - 2006/12/1. Y1 - 2006/12/1. N2 - Adsorptive desulfurization of a model fuel over CeO2-based adsorbents was conducted in a flowing adsorption system at 25 oC under ambient pressure without using H2 gas in order to evaluate the desulfurization performance of the adsorbent for producing ultra-low-sulfur fuel. For adsorption test, the capacity and selectivity of CeO2-based adsorbents for various sulfur compounds and the co-existing olefin and aromatic compound were used. Doping Ti and W into CeO2 significantly improved the sulfur removing capacity. The breakthrough sequence of the compounds over the CeO2-based adsorbents was, 1-C8 olefin °Ö toluene , thiophene , benzothiophene , 2-methyl benzothiophene , tetrahydrothiophene. By comparison of selectivity study and computational analysis, it was found that the electron ...
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Managing Diabetic Peripheral Neuropathic Pain (DPNP)Managing Diabetic Peripheral Neuropathic Pain (DPNP)
Because of the prevalence of overweight (BMI 25-29.9) and obesity (30-39.9) in the United States, the incidence of diabetes is increasing.1 By the year 2010, the World Health Organization (WHO) estimates that there will be 220 million people with this disease worldwide.2 These statistics demonstrate the need to educate the physician not only about
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Evaluation of the Efficacy and Safety of Rivaroxaban Using a Computer Model for Blood CoagulationEvaluation of the Efficacy and Safety of Rivaroxaban Using a Computer Model for Blood Coagulation
Rivaroxaban is an oral, direct Factor Xa inhibitor approved in the European Union and several other countries for the prevention of venous thromboembolism in adult patients undergoing elective hip or knee replacement surgery and is in advanced clinical development for the treatment of thromboembolic disorders. Its mechanism of action is antithrombin independent and differs from that of other anticoagulants, such as warfarin (a vitamin K antagonist), enoxaparin (an indirect thrombin/Factor Xa inhibitor) and dabigatran (a direct thrombin inhibitor). A blood coagulation computer model has been developed, based on several published models and preclinical and clinical data. Unlike previous models, the current model takes into account both the intrinsic and extrinsic pathways of the coagulation cascade, and possesses some unique features, including a blood flow component and a portfolio of drug action mechanisms. This study aimed to use the model to compare the mechanism of action of rivaroxaban with that of
Papers with the keyword use of rivaroxaban in children | Read by QxMDPapers with the keyword use of rivaroxaban in children | Read by QxMD
Novel oral anticoagulants offer equivalent or improved therapeutic profiles compared with warfarin, with less risk of bleeding, no interactions with food, and no need for routine laboratory monitoring. Caution must be exercised in using these drugs in certain patient populations, for example, renal insufficiency, those receiving additional antithrombotic therapy, those with questionable compliance, children, and those with a high risk of gastrointestinal bleeding. One of the novel oral anticoagulants, rivaroxaban, is a direct Factor Xa inhibitor, used to reduce risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, deep vein thrombosis, and pulmonary embolism ...
Raltitrexed - WikipediaRaltitrexed - Wikipedia
Raltitrexed (Tomudex, TDX, ZD 1694) is an antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca. Used in treatment of colorectal cancer since 1998. It may also be used in the treatment of malignant mesothelioma. Raltitrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites, which inhibit one or more of three enzymes that use folate and derivatives as substrates: DHFR, GARFT and thymidylate synthase. Raltitrexed is fully active after polyglutamylation, which allows cellular retention of the drug. By inhibiting Thymidylate synthase (TS), thus formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells. Inhibition of L1210 cell growth in culture IC50 = 9 nM, is one of the strongest antimetabolites in use. Structure and phase I clinical trial of the ...
CPC-124 Rivaroxaban or Conventional Thromboprophylaxis After Major Orthopaedic Surgery in Routine Practise: Influence of Co...CPC-124 Rivaroxaban or Conventional Thromboprophylaxis After Major Orthopaedic Surgery in Routine Practise: Influence of Co...
Results XAMOS enrolled 17,701 patients; the safety population included 17,413 patients, of whom 8778 received rivaroxaban and 8635 received SOC (81.7% low molecular weight heparin). Baseline patient demographics and use of cytochrome P450 (CYP) 3A4 inhibitors or inducers and platelet aggregation inhibitors (PAIs) before surgery were similar between groups; these drugs were used less frequently after surgery. There was a significant reduction in the incidence of symptomatic thromboembolic events in the rivaroxaban group compared with the SOC group, with numerically but not statistically higher incidence of major bleeding events. Concomitant use of PAIs was associated with higher incidences of symptomatic thromboembolic and any bleeding events compared with non-use in both the rivaroxaban and the SOC groups (Table).. ...
Rivaroxaban better than aspirin at preventing DVT | Good Health CareRivaroxaban better than aspirin at preventing DVT | Good Health Care
An international research team has found that the blood thinner rivaroxaban is as safe as aspirin, and more effective at preventing recurrence of life-threatening blood clots in the legs and lungs.. The large international study of 3,396 patients with venous thromboembolism in 31 countries, published the New England Journal of Medicine. shows that rivaroxaban is more effective than aspirin.. "Not only that, but in testing two doses of rivaroxaban, we found that we have the option of lowering the daily dose for extended treatment," said Dr. Jeffrey Weitz, principal investigator of the study and professor of medicine and biochemistry and biomedical sciences at the Michael G. DeGroote School of Medicine at McMaster University. "This will ease the long-term concerns of both patients and their doctors.". During the study from March 2014 to March 2016, patients received either a daily 20mg dose of rivaroxaban, a 10mg dose of rivaroxaban, or a 100 mg dose of aspirin. They took these medications for up ...
Xarelto (rivaroxaban) is a selective, direct acting Factor Xa inhibitor. - PDFXarelto (rivaroxaban) is a selective, direct acting Factor Xa inhibitor. - PDF
PRODUCT INFORMATION XARELTO (rivaroxaban) NAME OF THE MEDICINE Xarelto (rivaroxaban) is a selective, direct acting Factor Xa inhibitor. Rivaroxaban is 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-
Effect of Strontium Ranelate on the Muscle and Vertebrae of Ovariectomized Rats | springermedizin.deEffect of Strontium Ranelate on the Muscle and Vertebrae of Ovariectomized Rats | springermedizin.de
Osteoporosis is often accompanied by sarcopenia. The effect of strontium ranelate (SR) on muscle tissue has not been investigated sufficiently. In
Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moietySynthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety
We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivative
Difference between revisions of OpenSourceMalaria:GSK Amino-thienopyrimidine Series - OpenWetWareDifference between revisions of "OpenSourceMalaria:GSK Amino-thienopyrimidine Series" - OpenWetWare
The step that involves n-BuLi would best be avoided, and if a more direct route of arriving at the Suzuki coupling step could be discovered, that would take a potentially dangerous and difficult step out of the synthetic route. One possibility, involving NIS and an ionic liquid such as 1-Butyl-3-methylimidazolium tetrafluoroborate (which our lab doesnt have, but which is available from Aldrich in catalytic quality from $247/5g), is found below: [doi:10.1016/j.tetlet.2011.03.010 DOI] [dx.doi.org/10.1139/V09-125 Here] is another alternative, where the direct iodonation of arenes can be carried out using oxone and NaI. Whether or not this would work in my compound, given selectivity issues, is something that Ill have to investigate. This paper shows a method of direct halogenation of thiophenes. This uses [Bis(trifluoroacetoxy)iodo]benzene, which we dont have lying around, but which can be bought from Aldrich for $136/10g. The reactivity of thiophenes vs pyrimidines is something Ill have to ...
Difference between revisions of OpenSourceMalaria:GSK Amino-thienopyrimidine Series - OpenWetWareDifference between revisions of "OpenSourceMalaria:GSK Amino-thienopyrimidine Series" - OpenWetWare
The step that involves n-BuLi would best be avoided, and if a more direct route of arriving at the Suzuki coupling step could be discovered, that would take a potentially dangerous and difficult step out of the synthetic route. One possibility, involving NIS and an ionic liquid such as 1-Butyl-3-methylimidazolium tetrafluoroborate (which our lab doesnt have, but which is available from Aldrich in catalytic quality from $247/5g), is found below: [doi:10.1016/j.tetlet.2011.03.010 DOI] [dx.doi.org/10.1139/V09-125 Here] is another alternative, where the direct iodonation of arenes can be carried out using oxone and NaI. Whether or not this would work in my compound, given selectivity issues, is something that Ill have to investigate. This paper shows a method of direct halogenation of thiophenes. This uses [Bis(trifluoroacetoxy)iodo]benzene, which we dont have lying around, but which can be bought from Aldrich for $136/10g. The reactivity of thiophenes vs pyrimidines is something Ill have to ...
Pyrene‐cored covalent organic polymers by thiophene‐based isomers, their gas adsorption, and photophysical propertiesPyrene‐cored covalent organic polymers by thiophene‐based isomers, their gas adsorption, and photophysical properties
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
ThienothiopheneThienothiophene
ThiopropamineThiopropamine
BenzothiopheneBenzothiophene
Sulfide (organic)Sulfide (organic)
TerthiopheneTerthiophene
Dialkylbiaryl phosphine ligandsDialkylbiaryl phosphine ligands
Asymmetric hydrogenationAsymmetric hydrogenation
SelenopheneSelenophene
ArsoleArsole
Phosphorus pentasulfidePhosphorus pentasulfide
IsatinIsatin
Heterocyclic compoundHeterocyclic compound
Xanthobacter tagetidisXanthobacter tagetidis
Sigma-1 receptorSigma-1 receptor
SulfoleneSulfolene
2,3-Dihydrothiophene2,3-Dihydrothiophene
Heterocyclic compoundHeterocyclic compound
TetrahydrothiopheneTetrahydrothiophene
BiotinBiotin
R. Bruce KingR. Bruce King
Triiron dodecacarbonylTriiron dodecacarbonyl
CirculeneCirculene
Nickel(II) precatalystsNickel(II) precatalysts
Backbone chainBackbone chain
Electrophilic aromatic substitutionElectrophilic aromatic substitution
Wilhelm SteinkopfWilhelm Steinkopf
David M. LemalDavid M. Lemal
MethiopropamineMethiopropamine
2-Acetylfuran2-Acetylfuran
Aquamicrobium defluviiAquamicrobium defluvii
OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
ThiophenesFuransEchinops PlantChemistry Techniques, SyntheticAnisolesMolecular StructureCyclizationHeterocyclic CompoundsPalladiumSulfur CompoundsCombinatorial Chemistry TechniquesStructure-Activity RelationshipStereoisomerismCatalysisSemiconductorsTransistors, ElectronicSublimationPatents as TopicCadmium CompoundsBromine CompoundsTerminology as TopicSafetyAccidents, OccupationalDatabases, ChemicalFactor XaPubMedPeriodicals as TopicBooksPublishingMEDLINESerial PublicationsDatabases, ProteinInternetUser-Computer InterfaceCrystallography, X-RayModels, MolecularSoftwareInfrared RaysLasersPhotonsLaser Therapy, Low-LevelLasers, SemiconductorLaser TherapyQuantum TheoryMolecular ConformationThermodynamicsElectronsTransition ElementsPolymersElectroplatingQuantum DotsBicyclo Compounds, HeterocyclicElectronicsMolecular Imaging
Thiophene-2-carbothioamide | C5H5NS2 - PubChemThiophene-2-carbothioamide | C5H5NS2 - PubChem
RCSB PDB - 2H4G: Crystal structure of PTP1B with monocyclic thiophene inhibitorRCSB PDB - 2H4G: Crystal structure of PTP1B with monocyclic thiophene inhibitor
Infrared laser multiple photon dissociation of thiophene in gas phase | SpringerLinkInfrared laser multiple photon dissociation of thiophene in gas phase | SpringerLink
IJMS | Free Full-Text | Origin and Distribution of Thiophenes and Furans in Gas Discharges from Active Volcanoes and Geothermal...IJMS | Free Full-Text | Origin and Distribution of Thiophenes and Furans in Gas Discharges from Active Volcanoes and Geothermal...
ASTM D4735 - 15 Standard Test Method for Determination of Trace Thiophene in Refined Benzene by Gas ChromatographyASTM D4735 - 15 Standard Test Method for Determination of Trace Thiophene in Refined Benzene by Gas Chromatography
Human Metabolome Database: Showing metabocard for Thiophene (HMDB0029718)Human Metabolome Database: Showing metabocard for Thiophene (HMDB0029718)
Patent US4994564 - Azo dyes with a diazo component of the 3-amino thiophene series and a ... - Google PatentsPatent US4994564 - Azo dyes with a diazo component of the 3-amino thiophene series and a ... - Google Patents
Evaluation of amplified spontaneous emission from photopumped thiophene/phenylene co-oligomers in polycrystalline states | ...Evaluation of amplified spontaneous emission from photopumped thiophene/phenylene co-oligomers in polycrystalline states | ...
Synthesis and reactivity of thiophene palladium and thiophene dipalladium complexes with unsaturated molecules.Synthesis and reactivity of thiophene palladium and thiophene dipalladium complexes with unsaturated molecules.
N-cyclopropylmethyl-7-(1-hydroxy-1-methyl-3-(2-thiophene)propyl)-6,14-endoethanotetrahydrooripavine Summary Report |...N-cyclopropylmethyl-7-(1-hydroxy-1-methyl-3-(2-thiophene)propyl)-6,14-endoethanotetrahydrooripavine Summary Report |...
Plus itPlus it
Thiophene - WikipediaThiophene - Wikipedia
Benzo(c)thiophene - WikipediaBenzo(c)thiophene - Wikipedia
NIOSHTIC-2 Publications Search - 10010328 - Thiophenes.NIOSHTIC-2 Publications Search - 10010328 - Thiophenes.
ThiopheneThiophene
ThiopheneThiophene
Patent US6608323 - n-type thiophene semiconductors - Google PatentsPatent US6608323 - n-type thiophene semiconductors - Google Patents
4-(thiophene-2-carbonyl)oxolan-2-one4-(thiophene-2-carbonyl)oxolan-2-one
2-diethylaminoethyl 4-(thiophene-2-carbonylamino)benzoate2-diethylaminoethyl 4-(thiophene-2-carbonylamino)benzoate
Thieno[3,2-b]thiophene 95% | Sigma-AldrichThieno[3,2-b]thiophene 95% | Sigma-Aldrich
Ethyl thiophene-3-carboxylate | C7H8O2S - PubChemEthyl thiophene-3-carboxylate | C7H8O2S - PubChem
Thiophene and Its Derivatives, Part 2, Volume 44 | Organic Chemistry | Chemistry | Subjects | WileyThiophene and Its Derivatives, Part 2, Volume 44 | Organic Chemistry | Chemistry | Subjects | Wiley
Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. - PubMed - NCBIThiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. - PubMed - NCBI
New Thiophene Monolayer-Protected Copper Nanoparticles: Synthesis and Chemical-Physical CharacterizationNew Thiophene Monolayer-Protected Copper Nanoparticles: Synthesis and Chemical-Physical Characterization
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Thiophene - Properties | Technology TrendsThiophene - Properties | Technology Trends
Alfa Aesar Thiophene-2-sulfonyl chloride, 97% | Fisher ScientificAlfa Aesar Thiophene-2-sulfonyl chloride, 97% | Fisher Scientific
Thiophene-3-malonic acid - Registration Dossier - ECHAThiophene-3-malonic acid - Registration Dossier - ECHA
A Thermochemical Parameters and Theoretical Study of the Chlorinated Compounds of ThiopheneA Thermochemical Parameters and Theoretical Study of the Chlorinated Compounds of Thiophene
TCI AMERICAS Thieno[3,2-B]Thiophene,1g - 20DA65|T2513-1G - GraingerTCI AMERICAS Thieno[3,2-B]Thiophene,1g - 20DA65|T2513-1G - Grainger
Anion-radical formation in the adsorption of thiophene and its derivatives on H-mordenite | SpringerLinkAnion-radical formation in the adsorption of thiophene and its derivatives on H-mordenite | SpringerLink
TCI AMERICAS Benzo[b]thiophene-2-ylboronic Acid,25g - 29KE65|B2893-25G - GraingerTCI AMERICAS Benzo[b]thiophene-2-ylboronic Acid,25g - 29KE65|B2893-25G - Grainger
2-heptylcyclopentylidene)amino] thiophene-2-carboxylate2-heptylcyclopentylidene)amino] thiophene-2-carboxylate
Density functional theory study of neutral and oxidized thiophene oligomers (Journal Article) | SciTech ConnectDensity functional theory study of neutral and oxidized thiophene oligomers (Journal Article) | SciTech Connect
Benzo[B]Thiophene-2-Boronic Acid - DrugBankBenzo[B]Thiophene-2-Boronic Acid - DrugBank
Archive ouverte HAL - Thiophene-based aldehyde derivatives for functionalizable & adhesive semiconducting polymersArchive ouverte HAL - Thiophene-based aldehyde derivatives for functionalizable & adhesive semiconducting polymers
Regioselective palladium-catalyzed arylation of 3-carboalkoxy furan and thiophene. | Sigma-AldrichRegioselective palladium-catalyzed arylation of 3-carboalkoxy furan and thiophene. | Sigma-Aldrich
Domino Synthesis of Tetrasubstituted Thiophenes from 1,3-Enynes with MercaptoacetaldehydeDomino Synthesis of Tetrasubstituted Thiophenes from 1,3-Enynes with Mercaptoacetaldehyde
OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
ThiophenesFuransEchinops PlantChemistry Techniques, SyntheticAnisolesMolecular StructureCyclizationHeterocyclic CompoundsPalladiumSulfur CompoundsCombinatorial Chemistry TechniquesStructure-Activity RelationshipStereoisomerismCatalysisSemiconductorsTransistors, ElectronicSublimationPatents as TopicCadmium CompoundsBromine CompoundsTerminology as TopicSafetyAccidents, OccupationalDatabases, ChemicalFactor XaPubMedPeriodicals as TopicBooksPublishingMEDLINESerial PublicationsDatabases, ProteinInternetUser-Computer InterfaceCrystallography, X-RayModels, MolecularSoftwareInfrared RaysLasersPhotonsLaser Therapy, Low-LevelLasers, SemiconductorLaser TherapyQuantum TheoryMolecular ConformationThermodynamicsElectronsTransition ElementsPolymersElectroplatingQuantum DotsBicyclo Compounds, HeterocyclicElectronicsMolecular Imaging
BenzoBenzeneReactivity of thiopheneMonocyclicSulfurFuranComplexesStructureGroupBenzoDerivativesCompoundsPOLYMERSPyrroleInhibitorsThienoReactivityBenzothiophene and dibenzothiopheneAminoSubstituentsPolymerHeterocyclicViktor MeyerOxidationAcidDerivativeSulfurRegioregular poly2017DecompositionMethanolMetabolic activationElectrochemical methodThermalChemistrySOLVENTSHydrogenMONOMERSSuppliersPropertiesMoietiesReactions
Benzo8
Benzene8
  • 4.2 This test method was found applicable for determining thiophene in refined benzene conforming to the specifications described in Specification D2359 and may be applicable toward other grades of benzene if the user has taken the necessary precautions as described in the text. (astm.org)
  • 1.1 This test method covers the determination of thiophene in refined benzene in the range from 0.80 to 1.80 mg/kg for the Flame Photometric Detector (FPD), and from 0.14 to 2.61 mg/kg for the Pulsed Flame Photometric Detector (PFPD). (astm.org)
  • 1.2 This test method has been found applicable to benzene characteristic of the type described in Specifications D2359 and D4734 and may be applicable to other types or grades of benzene only after the user has demonstrated that the procedure can completely resolve thiophene from the other organic contaminants contained in the sample. (astm.org)
  • Thiophene is a maillard product At room temperature, thiophene is a colorless liquid with a mildly pleasant odor reminiscent of benzene, with which thiophene shares some similarities. (hmdb.ca)
  • The high reactivity of thiophene toward sulfonation is the basis for the separation of thiophene from benzene, which are difficult to separate by distillation due to their similar boiling points (4 C difference at ambient pressure). (hmdb.ca)
  • Like benzene, thiophene forms an azeotrope with water. (hmdb.ca)
  • Spacial constraints are achieved by the incorporation of rigid groups such as pyridine, thiophene and benzene rings. (icmab.es)
  • Nitrogen in pyridine always participate in coordination, sulfur in thiophene only occasionally and we have never found benzene participating. (icmab.es)
Reactivity of thiophene1
Monocyclic1
Sulfur1
Furan2
  • We have compared CNDO/2 and ab initio STO-3G calculations for furan and thiophene with and without the inclusion of 3d-orbitals on oxygen and on sulphur. (elsevier.com)
  • Enhanced aromaticity of thiophene compared to furan is primarily due to the delocalization of C2C3 π-bonds to the vacant d-orbitals of sulphur. (elsevier.com)
Complexes1
  • examples of insertion of CO into thiophene-palladium (II) complexes leading to acylpalladium (II) complexes have been reported.12 In this paper, we wish to present the reactivity of novel thiophene-palladium complexes, in particular their reactions with different molarities of CO and isocyanides. (docme.ru)
Structure1
  • Náray-Szabó, G & Peterson, MR 1981, ' d-orbital participation in bonding in thiophene: Comparison of CNDO/2 and ab initio results ', Journal of Molecular Structure: THEOCHEM , vol. 85, no. 3-4, pp. 249-255. (elsevier.com)
Group3
  • Thiophene 3-substituted with an imidazolyl group was synthesized and electropolymerized. (elsevier.com)
  • Kobayashi, T , Oyaizu, K & Yuasa, M 2005, ' Properties of electropolymerized thiophene film 3-substituted with imidazolyl group ', Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan, 05/9/20 - 05/9/22 pp. 3353-3354. (elsevier.com)
  • In the drawing a macrocycle with a thiophene rigid group and three thioeters in the molecule is schown to coordinate exo-dentately to Cu(I) producing a dinuclear copper complex. (icmab.es)
Benzo9
Derivatives10
Compounds5
POLYMERS3
  • The polymers based on di-thiophene and benzothiadiazole were applied in photovoltaic devices and the coupling of the alkylthiophene showed no effect on the maximum photovoltaic performance. (spie.org)
  • Band-gaps were estimated to be 2 eV for polymers based on di-thiophene and benzothiadiazole and 1.8 eV for polymers based on quarterthiophene and benzothiadiazole. (spie.org)
  • Poly(3,4-ethylenedioxy)thiophene−poly(styrene sulfonate) (PEDOT−PSS) was used as the conductive component in a matrix of chemically different insulating polymers to form an array of vapor detectors. (caltech.edu)
Pyrrole2
  • A copolymer comprising 1,4-diketopyrrolo[3,4- c ]pyrrole (DPP) and thieno[3,2- b ]thiophene moieties, PDBT-co-TT, shows high hole mobility of up to 0.94 cm 2 V −1 s −1 in organic thin-film transistors. (wiley.com)
  • In this study, we report the development of an enzyme immobilization matrix that displays enhanced electrochemical performance thanks to a novel conductive thin film prepared via in situ electrocopolymerization of pyrrole (Py) and thiophene-grafted chitosan (Th-Ch). This is a simple thin film preparation method that can help overcome aforementioned challenges by providing a uniformly distributed conductive layer on the electrode. (monash.edu)
Inhibitors3
Thieno1
Reactivity3
Benzothiophene and dibenzothiophene1
Amino1
  • We provide independent and unbiased information on manufacturers, prices, production news and consumers for the global and regional (North America, Asia and Europe) market of Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate. (reportsnreports.com)
Substituents1
Polymer5
  • 6. The field effect transistor device of claim 1 wherein said n-type organic semiconducting material is a polythiophene polymer with more than seven conjugated thiophene moieties. (google.co.uk)
  • 8. The field effect transistor of claim 7 , where said polythiophene polymer is regioregular, head-to-tail poly-3-C n F 2n+1 -thiophene. (google.co.uk)
  • The solubility of the polymer based on quarterthiophene and benzothiadiazole was tested with hexyl, 2-ethyl-hexyl and dodecyl as side chains on the thiophene. (spie.org)
  • The use of thiophene polymer film as an electrochromic material for display devices is proposed. (ip.com)
  • In this work we present the effect of HiPCO single walled carbon nanotubes (SWCNT) introduction into the conjugated polymer matrix poly(3-hexyl thiophene) (P3HT) on the structural and thermal stability of these nanocomposites. (epjap.org)
Heterocyclic4
Viktor Meyer1
Oxidation7
Acid4
  • 3-Thiophenecarboxylic acid has been used in the preparation of novel acetylene monomer, required for the synthesis of poly(2-methylbut-2-enyl thiophene-3-carboxylate) and oxazolines and oxazoles. (alfa.com)
  • Seven new thiophene-derived N -substituted dimethyl aminomethylphosphonic acid esters 2a - h were synthesized by the addition of an appropriate phosphite to azomethine bond of starting Schiff bases 1a - h , and NMR spectroscopic properties of aminophosphonates were investigated. (mdpi.com)
  • Thermogravimetry with evolved gas analysis by infrared spectrometry was used to study the thermal degradation of thiophene fulgamic acid in an inert atmosphere. (sump4.com)
  • Comparison of the results obtained from different experiments showed that the decomposition of thiophene fulgamic acid was more complex than simple ammonia loss followed by sublimation of the anticipated thiophene fulgide residue. (sump4.com)
Derivative1
  • Such thiophene derivative that is often used in medicinal chemistry is the α -chlorothiophene, and there are several examples of marketed drugs containing this moiety such as tioconazole, lornoxicam, and rivaroxaban [ 4 ]. (hindawi.com)
Sulfur2
  • Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. (wikipedia.org)
  • Specialized thiophenes can be synthesized similarly using Lawesson's reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. (wikipedia.org)
Regioregular poly2
  • Direct current and alternating current electrical transport properties of regioregular poly[3-(4-alkoxyphenyl)-thiophenes]. (unina.it)
  • transport properties of doped and undoped regioregular poly[3-(4-alkoxyphenyl)-thiophenes], where the alkoxy groups are O-(CH2)n-1CH3 with n = 1,4,6, and 8, have been investigated. (unina.it)
20171
  • The global market size of 2-Thiophene Acetyl Chloride is $XX million in 2017 with XX CAGR from 2013 to 2017, and it is expected to reach $XX million by the end of 2023 with a CAGR of XX% from 2018 to 2023. (marketpublishers.com)
Decomposition1
Methanol8
  • A titanium-based zeolitic thiophene-benzimidazolate framework has been designed for the direct synthesis of dimethyl carbonate (DMC) from methanol and carbon dioxide. (epa.gov)
  • The ' Global and Chinese 2-Thiophene Methanol Industry, 2011-2021 Market Research Report ' is a professional and in-depth study on the current state of the global 2-Thiophene Methanol industry with a focus on the Chinese market. (marketresearch.com)
  • The report provides key statistics on the market status of the 2-Thiophene Methanol manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. (marketresearch.com)
  • Through the statistical analysis, the report depicts the global and Chinese total market of 2-Thiophene Methanol industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. (marketresearch.com)
  • The report then estimates 2016-2021 market development trends of 2-Thiophene Methanol industry. (marketresearch.com)
  • In the end, the report makes some important proposals for a new project of 2-Thiophene Methanol Industry before evaluating its feasibility. (marketresearch.com)
  • Overall, the report provides an in-depth insight of 2011-2021 global and Chinese 2-Thiophene Methanol industry covering all important parameters. (marketresearch.com)
  • 5.2 Market Competition of 2-Thiophene Methanol Industry by Country (USA, EU, Japan, Chinese etc. (marketresearch.com)
Metabolic activation1
  • Enclosed functional groups of MP are structural alerts for metabolic activation to reactive intermediates: thiophene ring ( S -oxide and epoxide), pyridine ring (epoxide and p -quinone iminium ion), and alkyl nitrogens (iminium ions). (aspetjournals.org)
Electrochemical method1
Thermal5
  • Introduction of perfluorocarbon chains on the thiophene core affords enhanced thermal stability and volatility, and increased electron affinity versus the fluorine-free analog 2. (google.co.uk)
  • language = {cze}, issn = {0009-2770}, journal = {Chemické listy}, title = {Esters and Nitriles of 2-(3-Acylselenoureido)benzoic and -thiophene-3-carboxylic Acids Thermal Transformations. (muni.cz)
  • Thermal behaviour of esters and nitriles of 2-(3-acylselenoureido)benzoic and -thiophene-3-carboxylic acids in solid phase and melt were studied. (muni.cz)
  • Control experiments on the thermal degradation of thiophene fulgide indicated an initial loss of a nitrile containing species. (sump4.com)
  • thermal racemization (Delta G(double dagger) = 25.1 kcal mol(-1)) of the enantiopure metabolite (1R)-2-methylbenzo[b]thiophene 1-oxide has been observed. (warwick.ac.uk)
Chemistry3
  • This contribution sets out to compute thermochemical and geometrical parameters of the complete series of chlorinated isomers of thiophene based on the accurate chemistry model of CBS-QB3. (hindawi.com)
  • Medicinal chemistry approaches to minimize the bioactivation potential of thiophenes often include substitution at the α -carbon position to provide a potential site for metabolism. (hindawi.com)
  • Jonathan Swanston "Thiophene" in Ullmann's Encyclopedia of Industrial Chemistry Wiley-VCH, Weinheim, 2006. (academic.ru)
SOLVENTS1
Hydrogen2
  • Thiophenes undergo hydrogenolysis to form hydrocarbons and hydrogen sulfide. (wikipedia.org)
  • Mass spectrometric and hydrogen/deuterium exchange analysis of the glutathione adduct produced by rat liver microsomes indicated that the metabolite was most probably a thioether of MP S -oxide substituted in the thiophene ring. (aspetjournals.org)
MONOMERS1
  • 29 , 30 Motivated by all the above, we selected two isomeric monomers in which a thiophene ring is attached at either the 2‐ or 3‐ position to pyrene at its 1‐, 3‐, 6‐, and 8‐ positions. (pubmedcentralcanada.ca)
Suppliers1
Properties3
Moieties1
Reactions1
  • The results highlight the importance of the modifications ported to the well-known one-phase synthetic reactions to obtain a clear lack, even after a storage of six months, of any irreversible aggregation that has always characterized chain thiophene-protected metallic nanoparticles. (hindawi.com)
IJMS | Free Full-Text | Origin and Distribution of Thiophenes and Furans in Gas Discharges from Active Volcanoes and Geothermal...
IJMS | Free Full-Text | Origin and Distribution of Thiophenes and Furans in Gas Discharges from Active Volcanoes and Geothermal... (mdpi.com)
RCSB PDB - 2H4G: Crystal structure of PTP1B with monocyclic thiophene inhibitor
RCSB PDB - 2H4G: Crystal structure of PTP1B with monocyclic thiophene inhibitor (rcsb.org)
Human Metabolome Database: Showing metabocard for Thiophene (HMDB0029718)
Human Metabolome Database: Showing metabocard for Thiophene (HMDB0029718) (hmdb.ca)
Sulfide (organic) - Wikipedia
Sulfide (organic) - Wikipedia (en.m.wikipedia.org)
Guide to Fluorine NMR for Organic Chemists, 2nd Edition | Organic Chemistry | Chemistry | Subjects | Wiley
Guide to Fluorine NMR for Organic Chemists, 2nd Edition | Organic Chemistry | Chemistry | Subjects | Wiley (wiley.com)
Iridium(III) in Optoelectronic and Photonics Applications, 2 Volume Set | Inorganic Electronics | Electronic Materials |...
Iridium(III) in Optoelectronic and Photonics Applications, 2 Volume Set | Inorganic Electronics | Electronic Materials |... (wiley.com)
Annual Reports in Organic Synthesis (2003), Volume 2003 by Philip M. Weintraub | 9780120408337 | Booktopia
Annual Reports in Organic Synthesis (2003), Volume 2003 by Philip M. Weintraub | 9780120408337 | Booktopia (booktopia.com.au)
Heterocyclic Communications
Heterocyclic Communications (degruyter.com)
Mars Science Laboratory
Mars Science Laboratory (universetoday.com)
Domino Synthesis of Tetrasubstituted Thiophenes from 1,3-Enynes with Mercaptoacetaldehyde
Domino Synthesis of Tetrasubstituted Thiophenes from 1,3-Enynes with Mercaptoacetaldehyde (organic-chemistry.org)
Polymer Photovoltaics: A Practical Approach | (2008) | Krebs | Publications | Spie
Polymer Photovoltaics: A Practical Approach | (2008) | Krebs | Publications | Spie (spie.org)
2 Utilizing Chemical Imaging to Address Scientific and Technical Challenges: Case Studies | Visualizing Chemistry: The Progress...
2 Utilizing Chemical Imaging to Address Scientific and Technical Challenges: Case Studies | Visualizing Chemistry: The Progress... (nap.edu)
Identifying the missing link in catalyst transfer polymerization | Nature Communications
Identifying the missing link in catalyst transfer polymerization | Nature Communications (nature.com)
ExoMars rover Archives - Universe Today
ExoMars rover Archives - Universe Today (universetoday.com)
Sensors and Microsystems | SpringerLink
Sensors and Microsystems | SpringerLink (link.springer.com)
Articaine - DrugBank
Articaine - DrugBank (drugbank.ca)
Open Access Articles ::: Letters in Organic Chemistry
Open Access Articles ::: Letters in Organic Chemistry (benthamscience.com)
Name Reactions in Heterocyclic Chemistry II | Organic Chemistry | Chemistry | Subjects | Wiley
Name Reactions in Heterocyclic Chemistry II | Organic Chemistry | Chemistry | Subjects | Wiley (wiley.com)