Carbamates in which the -CO- group has been replaced by a -CS- group.

Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamylcysteine synthetase and increases intracellular glutathione levels. (1/638)

Time- and dose-dependent increases in the steady-state mRNA levels of the genes encoding the catalytic and regulatory subunits of the enzyme gamma-glutamylcysteine synthetase (GCS) were observed in HepG2 human hepatocarcinoma cells after exposure to pyrrolidine dithiocarbamate (PDTC). PDTC was demonstrated to manifest both antioxidant and pro-oxidant properties in HepG2 cells, as assessed by the decreased fluorescence of the redox-sensitive dye Dihydrorhodamine 123 and by the oxidation of glutathione respectively. Attempts to characterize the signalling pathway from PDTC exposure to increases in the expression of the GCS catalytic and regulatory subunit genes demonstrated that induction by PDTC could be partially blocked by treatment with the thiol agent N-acetylcysteine and by the copper chelator bathocuproine disulphonic acid. These findings suggested that the up-regulation of the two genes resulted from a PDTC-induced pro-oxidant signal, which was partially copper-dependent. In summary, these studies demonstrate that PDTC exposure elicits a cellular response in HepG2 cells, characterized by the induction of the genes encoding the two subunits of the enzyme GCS and increased de novo synthesis of the cellular protectant GSH.  (+info)

Pyrrolidine dithiocarbamate prevents I-kappaB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs. (2/638)

Lipopolysaccharide (LPS) is a key mediator of multiple organ injury observed in septic shock. The mechanisms responsible for LPS-induced multiple organ injury remain obscure. In the present study, we tested the hypothesis that the LPS-induced injury occurs through activation of the transcription factor, nuclear factor-kappaB (NF-kappaB). We examined the effects of inhibiting NF-kappaB activation in vivo in the rat on LPS-induced: 1) gene and protein expression of the cytokine-inducible neutrophil chemoattractant (CINC) and intercellular adhesion molecule-1 (ICAM-1); b) neutrophil influx into lungs, heart, and liver; and c) increase in microvascular permeability induced by LPS in these organs. LPS (8 mg/kg, i.v.) challenge of rats activated NF-kappaB and induced CINC and ICAM-1 mRNA and protein expression. Pretreatment of rats with pyrrolidine dithiocarbamate (50, 100, and 200 mg/kg, i.p.), an inhibitor of NF-kappaB activation, prevented LPS-induced I-kappaBalpha degradation and the resultant NF-kappaB activation and inhibited, in a dose-related manner, the LPS-induced CINC and ICAM-1 mRNA and protein expression. Pyrrolidine dithiocarbamate also markedly reduced the LPS-induced tissue myeloperoxidase activity (an indicator of tissue neutrophil retention) and the LPS-induced increase in microvascular permeability in these organs. These results demonstrate that NF-kappaB activation is an important in vivo mechanism mediating LPS-induced CINC and ICAM-1 expression, as well as neutrophil recruitment, and the subsequent organ injury. Thus, inhibition of NF-kappaB activation may be an important strategy for the treatment of sepsis-induced multiple organ injury.  (+info)

Diesel exhaust particles induce NF-kappa B activation in human bronchial epithelial cells in vitro: importance in cytokine transcription. (3/638)

Fine particles derived from diesel engines (diesel exhaust particles, DEP) have attracted attention, since their density in industrial countries seems related to the increased prevalence of pulmonary diseases. Previous studies have suggested that DEP have a potential to directly activate airway epithelial cells to produce and release inflammatory cytokines and mediators, and thus facilitate inflammatory responses in the lung. To elucidate the molecular mechanisms of their action, we studied here IL-8 gene expression, one of the important cytokines in inflammatory responses, by Northern blot analysis and run-on transcription assay. Suspended DEP (1-50 microgram/ml) increased the steady state levels of IL-8 mRNA, which was suggested to be largely due to increased transcriptional rates. Electrophoretic mobility shift assay demonstrated that DEP induced increased binding to the specific motif of NF-kappa B, but not of transcription factor AP-1. The luciferase reporter gene assay using wild-type and mutated NF-kappa B-binding sequences showed that DEP-induced NF-kappa B activation was involved in IL-8 transcription. Finally, both N-acetylcysteine and pyrrolidine dithiocarbamate attenuated the action of DEP on IL-8 mRNA expression, suggesting that oxidant-mediated pathway might be involved in its processes. These results suggested that DEP activate NF-kappa B, which might be an important mechanism of its potential to increase the expression of inflammatory cytokines in vitro.  (+info)

Hematopoietic growth factors signal through the formation of reactive oxygen species. (4/638)

Hematopoietic growth factors (HGFs) stimulate growth, differentiation, and prevent apoptosis of progenitor cells. Each growth factor has a specific cell surface receptor, which activates both unique and shared signal transduction pathways. We found that several HGFs, including granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), steel factor (SF), and thrombopoietin (TPO) induce a rapid increase in reactive oxygen species (ROS) in quiescent cells. In an effort to understand the potential biochemical and biological consequences of increased ROS in these cells, we exposed growth factor-deprived cells to hydrogen peroxide (H2O2) at concentrations that increased intracellular ROS. H2O2 induced a dose-dependent increase in tyrosine phosphorylation, including increased tyrosine phosphorylation of the GM-CSF receptor beta chain (betac), STAT5, and other signaling proteins. H2O2 also induced expression of the early response gene c-FOS, and G1- to S-phase transition, but not S- to G2/M-phase transition of MO7e cells. The cell permeable antioxidant pyrrolidine dithiocarbamate (PDTC) decreased the intracellular levels of ROS and inhibited tyrosine phosphorylation induced by GM-CSF in MO7e cells, suggesting that ROS generation plays an important role in GM-CSF signaling. Consistent with this notion, PDTC and two other antioxidants, N-acetyl cysteine and 2-mercaptoethanol, reduced growth and viability of MO7e cells. These results suggest that generation of ROS in response to HGFs may contribute to downstream signaling events, especially those involving tyrosine phosphorylation.  (+info)

Spin trapping of nitric oxide by ferro-chelates: kinetic and in vivo pharmacokinetic studies. (5/638)

Biologically generated nitric oxide appears to play a pivotal role in the control of a diverse series of physiologic functions. Iron-chelates and low-frequency EPR spectroscopy have been used to verify in vivo production of nitric oxide. The interpretation of in vivo identification of nitric oxide localized at the site of evolution in real time is complicated by the varied kinetics of secretion. The quantitative efficiency of the spectroscopic measurement, so important in understanding the physiology of nitric oxide, remains elusive. The development of a more stable iron-chelate will help better define nitric oxide physiology. In this report, we present data comparing the commonly used ferro-di(N-methyl-D-glucamine-dithiocarbamate) (Fe2+(MGD)2) and the novel chelate ferro-di(N-(dithiocarboxy)sarcosine) (Fe2+(DTCS)2) quantifying the in vitro and in vivo stability of the corresponding spin trapped adducts, NO-Fe(MGD)2 and NO-Fe(DTCS)2. Finally, very low frequency EPR spectroscopy has been used to evaluate the pharmacokinetics of NO-Fe(MGD)2 and NO-Fe(DTCS)2 in mice in real time.  (+info)

Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation. (6/638)

Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-kappaB) activation. PDTC inhibited basal NF-kappaB activity of endothelial cells. PDTC, however, failed to inhibit basal NF-kappaB activity after withdrawal of serum in the media, and the inhibitory effect of PDTC could be restored by addition of zinc. When various preparations of metal ion-EDTA were tested with PDTC in serum-containing media, only Zn-EDTA failed to block the inhibitory effect of PDTC. The dependence on zinc was also noted in PDTC inhibition of NF-kappaB stimulated by TNF alpha. These facts suggest that zinc is required for PDTC inhibition of NF-kappaB activation.  (+info)

UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. (7/638)

We have previously shown that hydrogen peroxide is an important mediator of ultraviolet B induced phosphorylation of the epidermal growth factor receptor in human keratinocytes. Here we demonstrate that physiologic doses of ultraviolet B and hydrogen peroxide stimulate activation of two related but distinct mitogen-activated protein kinase pathways: extracellular regulated kinase 1 and 2 (ERK1/2), as well as p38, the mammalian homolog of HOG1 in yeast which is a major kinase for a recently identified stress-induced signaling pathway. The time-dependent activation of ERK1/2 and p38 are distinct, and ultraviolet B-induced ERK1/2 activation is downregulated more rapidly than p38. Using dihydrorhodamine or Amplex as specific fluorescent dye probes, we show that ultraviolet B-induced peroxides can be inhibited by ascorbic acid. Ascorbic acid strongly blocks ERK1/2 and p38 activation by ultraviolet B and hydrogen peroxide whereas pyrrolidine dithiocarbamate and butyl hydroxyanisole are less effective. Pyrrolidine dithiocarbamate was unable to inhibit ultraviolet B-induced p38 activation. Cell death was increased after ultraviolet B when ERK1/2 activation was attenuated by the specific inhibitor PD098059. The distinct time courses and extents of activation and inhibition of ERK1/2 and p38 indicate that these pathways are separate and regulated independently in keratinocytes. Specific types of reactive oxygen species induced by ultraviolet B as well as selective activation or inhibition of specific phosphatases may mediate these responses in keratinocytes. These findings demonstrate that reactive oxygen species are important multifunctional mediators of ultraviolet B-induced ERK1/2 and p38 signaling transduction pathways and suggest that ERK1/2 may play an important part in protecting keratinocytes from cell death following oxidative stress.  (+info)

Neurotoxicity and behavioral effects of thiram in rats. (8/638)

Eight of 24 female rats fed 66.9 mg/kg-day of thiram developed neurotoxicity. The neurotoxic effects were characterized by ataxia and paralysis of the hind legs. There were demyelination, degeneration of the axis cylinders, and presence of macrophages in the nerve bundle of the sciatic nerve. Degeneration in the ventral horn of the lower lumbar region of the spinal cord was evidenced by chromatolysis of motorneurons, pyknosis, and satellitosis. During a second experiment, 4 of 24 females fed 65.8 mg/kg--day also developed ataxia and paralysis. An additional 9 females showed clasping of the hind feet when picked up by the tail. Nerve conduction could not be measured for one severely ataxic rat and the electromyogram indicated a loss of motor unit function. Histopathology of this rat, along with the others, suggests the peripheral nerve as the primary site of the lesion. Thiram also caused behavioral changes in apparently normal rats. The walking pattern of the hind legs was altered with decreases in stride width and the angle between contralateral steps. These rats required significantly more shock-motivations and cleared a lower height in a jump/climb ability test. An open-field study indicated that thiram caused hyperactivity in the nonataxic rats of both sexes. Three of 24 rats fed 95.8 mg/kg-day of ferbam also developed ataxia or paralysis.  (+info)

Thiocarbamates are a group of chemical compounds that contain a functional group with the structure R-S-CO-NH-R', where R and R' represent organic groups. They are commonly used as herbicides, fungicides, and nematocides in agriculture due to their ability to inhibit certain enzymes in plants and pests.

In a medical context, thiocarbamates have been studied for their potential therapeutic effects, particularly as anti-cancer agents. Some thiocarbamate derivatives have been found to inhibit the growth of cancer cells by interfering with microtubule dynamics or by inducing apoptosis (programmed cell death). However, more research is needed to fully understand their mechanisms of action and potential side effects before they can be widely used in clinical settings.

There are two isomeric forms of thiocarbamates: O-thiocarbamates, ROC(=S)NR2 (esters), and S-thiocarbamates, RSC(=O)NR2 ( ... 2 R2NH + COS → [R2NH2+][R2NCOS−] In the Newman-Kwart rearrangement O-thiocarbamates can isomerise to S-thiocarbamates. This ... In organic chemistry, thiocarbamates (thiourethanes) are a family of organosulfur compounds. As the prefix thio- suggests, they ... Borate, Molybdenum, or Zinc thiocarbamates are also used in metal-to-metal lubrication proposes, mainly as an anti-oxidation or ...
The Riemschneider thiocarbamate synthesis converts alkyl or aryl thiocyanates to thiocarbamates under acidic conditions, ... Riemschneider, R.; Wojahn, F.; Orlick, G. (December 1951). "Thiocarbamates. III. Aryl Thiocarbamates from Aryl Thiocyanates". ... The Riemschneider thiocarbamate synthesis for aromatic compounds does not work efficiently for ortho-substituted compounds such ... The mechanism for the conversion of an alcohol to the N-substituted thiocarbamate is shown below. The reaction proceeds under ...
Mechanism of action Thiocarbamate antifungals have a similar mechanism of action as allylamine antifungals. They both inhibit ... "Thiocarbamate - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2022-04-23. Shi, D.; Zhao, Y.; Yan, H.; ... Clinical use Tolnaftate is one example of thiocarbamate antifungals. Tolnaftate Tolnaftate is a topically used antifungal for ... These drugs include benzoxaborole antifungals, ciclopirox olamine antifungals, thiocarbamate antifungals and undecylenic ...
Important compound classes are thiocarbonates, thiocarbamates, dithiocarbamates and trithiocarbonates. Small inorganic carbon ...
Other uses include the synthesis of thioamides and thiocarbamates. Like the analogous CDI, it may be used for peptide coupling ...
... is a thiocarbamate cholinesterase inhibitor used as an herbicide. Benthiocarb is almost always used to control the ... Thiocarbamate Tomlin, C.D.S., ed. (1997). The Pesticide Manual - World Compendium (11th ed.). Surrey, England: British Crop ... Thiocarbamates, Chloroarenes, All stub articles, Toxicology stubs). ...
... are hydrolyzed to thiocarbamates in the Riemschneider thiocarbamate synthesis. Isothiocyanate, isomers of ...
136-137 Thiocarbamate and dithiocarbamates are subclasses of carbamates. Prominent families of herbicides include phenoxy and ...
... dissolves in carbon disulfide, forming a complex thiocarbamate. Coniine solidifies into a soft crystalline mass at −2 ° ...
Thioester Thiocarbamate Thiocarbonate Thiocarbonic acid Thiocarbonate Cremlyn, R.J. (1996). An introduction to organosulfur ...
The Newman-Kwart rearrangement is a type of rearrangement reaction in which the aryl group of an O-aryl thiocarbamate, ArOC(=S) ... NMe2, migrates from the oxygen atom to the sulfur atom, forming an S-aryl thiocarbamate, ArSC(=O)NMe2. The reaction is named ... to form an O-aryl thiocarbamate (3). Heating 3 to around 250 °C causes it undergo Newman-Kwart rearrangement to an S-aryl ... S Rearrangement of O-Aryl Thiocarbamates". Synthesis. 2008 (5): 661-689. doi:10.1055/s-2008-1032179. Newman, M. S.; Karnes, H. ...
... is used as an intermediate in the production of thiocarbamate herbicides. The hydrolysis of carbonyl sulfide ... Steiger, Andrea K.; Pardue, Sibile; Kevil, Christopher G.; Pluth, Michael D. (2016-06-15). "Self-Immolative Thiocarbamates ...
Ryder NS, Frank I, Dupont MC (May 1986). "Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate ... Thiocarbamates, 3-Tolyl compounds, All stub articles, Antiinfective agent stubs, Dermatologic drug stubs). ...
... (INN) is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in ... Ryder NS, Frank I, Dupont MC (May 1986). "Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate ... a similar thiocarbamate antifungal "International Non-Proprietary Names for Pharmaceutical Preparations. Recommended ... Thiocarbamates, Merck & Co. brands, Bayer brands, 3-Tolyl compounds, 2-Naphthyl compounds). ...
S-thiocarbamates (3), RSC(=O)NR2, where the R-O- group is replaced with an R-S- group[citation needed] O-thiocarbamates can ... There are two different structurally isomeric types of thiocarbamate: O-thiocarbamates (2), ROC(=S)NR2, where the carbonyl ... Analogues of carbamates with only one of the oxygens replaced by sulfur are called thiocarbamates (2 and 3). Carbamates with ... isomerise to S-thiocarbamates, for example in the Newman-Kwart rearrangement.[citation needed] The etymology of the words " ...
... is prepared from 2-naphthol by the Newman-Kwart rearrangement starting from a thiocarbamate. It undergoes ...
RAFT polymerization uses thiocarbonylthio compounds, such as dithioesters, thiocarbamates, and xanthates, to mediate the ...
... contains thiocarbamates such as methyl N-benzylthiocarbamate, methyl and ethyl N-methoxybenzylthiocarbamate, and ...
... is a sulfur-containing oxazolidine, a cyclic thiocarbamate, that reduces the production of thyroid hormones such as ...
For tinea pedis, many antifungal creams such as miconazole nitrate, clotrimazole, tolnaftate (a synthetic thiocarbamate), ...
"Synthesis and Characterization of Some Mixed Alkyl Thiocarbamates of Gallium and Indium, Precursors for III/VI Materials: The X ...
Thiocarbamates, All stub articles, Genito-urinary system drug stubs). ...
... thiocarbamates MeSH D02.241.081.251.869.210 - dimethyldithiocarbamate MeSH D02.241.081.251.869.210.800 - thiram MeSH D02.241. ...
Thiocarbamates, Antifungals, Tetralins, Pyridines, Methoxy compounds, All stub articles, Antiinfective agent stubs). ...
Thiocarbamates, All stub articles, Antiinfective agent stubs). ...
... a synthetic thiocarbamate), terbinafine hydrochloride, butenafine hydrochloride and undecylenic acid. The fungal infection may ...
... when only 1 oxygen is replaced the result is thiocarbamate). Dithiocarbamate also refers to the dithiocarbamate ion R2N−CS−2 ...
Reissert compound Reppe synthesis Retropinacol rearrangement Rieche formylation Riemschneider thiocarbamate synthesis Riley ...
Selenium disulfide Sodium thiosulfate Sulfur Tolnaftate - a thiocarbamate antifungal, which inhibits fungal squalene epoxidase ...
There are two isomeric forms of thiocarbamates: O-thiocarbamates, ROC(=S)NR2 (esters), and S-thiocarbamates, RSC(=O)NR2 ( ... 2 R2NH + COS → [R2NH2+][R2NCOS−] In the Newman-Kwart rearrangement O-thiocarbamates can isomerise to S-thiocarbamates. This ... In organic chemistry, thiocarbamates (thiourethanes) are a family of organosulfur compounds. As the prefix thio- suggests, they ... Borate, Molybdenum, or Zinc thiocarbamates are also used in metal-to-metal lubrication proposes, mainly as an anti-oxidation or ...
Access to coumarins by rhodium-catalyzed oxidative annulation of aryl thiocarbamates with internal alkynes. Download Prime ... Access to Coumarins By Rhodium-catalyzed Oxidative Annulation of Aryl Thiocarbamates With Internal Alkynes. Org Lett. 2015 Mar ... Access to coumarins by rhodium-catalyzed oxidative annulation of aryl thiocarbamates with internal alkynes.. Org Lett. 2015 Mar ... Access to coumarins by rhodium-catalyzed oxidative annulation of aryl thiocarbamates with internal alkynes. Org Lett. 2015;17(6 ...
In 2021, Top exporters of Organo-sulphur compounds; thiocarbamates and dithiocarbamates to Malaysia were European Union ($ ... Organo-sulphur compounds; thiocarbamates and dithiocarbamates. 2021. Malaysia. 2.44. 60. Kg. Belgium. Export. 293020. Organo- ... Organo-sulphur compounds; thiocarbamates and dithiocarbamates. 2021. Malaysia. 7,737.29. 2,363,180. Kg. Italy. Export. 293020. ... Organo-sulphur compounds; thiocarbamates and dithiocarbamates. 2021. Malaysia. 1,832.95. 369,400. Kg. India. Export. 293020. ...
Herein, we report the synthesis and analysis of the structures and properties of a series of N,N-dimethyl-O-thiocarbamates, and ... It was observed that the aryl-thiocarbamate C-O bonds are twisted such that the planar aryl and carbamate moieties are ... Despite the desirable medicinal properties displayed by some N,N-disubstituted O-thiocarbamates, the study of the solid-state ... Investigating the solid-state assembly of pharmaceutically-relevant N,N-dimethyl-O-thiocarbamates in the absence of labile ...
Replacement Taylor Thiocarbamate Reagent 22ml #R-0643-A for your Taylor Test Kit and the maintenance of your pool. ... Home , Pool Accessories , Chemical Test Kits and Strips , Reagents Refills , Copper , Taylor Thiocarbamate Reagent 22ml #R-0643 ... Pool Vac Parts carries the Taylor Thiocarbamate Reagent 22mL (.75 oz) #R-0643-A ... Buy Taylor Thiocarbamate Reagent 22ml #R-0643-A, ... Taylor Thiocarbamate Reagent 22ml #R-0643-A. Manufacturer: ...
Thiocarbamates. Fumigant. 27. 5. 32. Sulfur. Insecticide/Fungicide. 38. 65. 103. Dipyridyls. Herbicide. 20. 65. 85. ...
Thiocarbamates.. Final screening assessments and risk management approaches (when needed). *Mitotane;. *BAPP; ...
thiocarbamates *tolciclate (Tolmicen ) *tolnaftate (Aftate , Tinactin , Tinaderm , ...) *haloprogin (Halotex ) *undecylenic ...
2013). Antitrypanosomal isothiocyanate and thiocarbamate glycosides from Moringa peregrina. Planta Med. 80, 86-89. doi: 10.1055 ... Murakami, A., Kitazono, Y., Jiwajinda, S., Koshimizu, K., and Ohigashi, H. (1998). Niaziminin, a thiocarbamate from the leaves ...
Determination of thiocarbamates in industrial and municipal wastewaters : butylate, cycloate, EPTC, molinate, pebulate, and ...
COMPETITION BETWEEN A THIOCARBAMATE HERBICIDE AND HERBICIDE PROTECTANTS AT THE LEVEL OF UPTAKE INTO MAIZE CELLS IN CULTURE ... They are also more susceptible to thiocarbamates (Laval-Martin et a1 1983), and the reason for this is unknown. We are likely ... RAPID EFFECTS OF A THIOCARBAMATE HERBICIDE AND ITS DICHLOROACETAMIDE PROTECTANT ON MACROMOLECULAR SYNTHESES AND GLUTATHIONE ...
The reaction is a highly atom-economic process for production of S-alkyl thiocarbamates.. N. Azizi, F. Aryanasab, M. R. Saidi, ...
... which are thiocarbamates, are stable in acidic environment (e.g. in the stomach) (Stark, 1964; Sabbioni et al., 1997; Reisser ...
... a synthetic thiocarbamate), terbinafine hydrochloride,[17] butenafine hydrochloride and undecylenic acid. The fungal infection ...
An Efficient, One-Pot Synthesis of S-Alkyl Thiocarbamates from the Corresponding Thiols Using the Mitsunobu Reagent. D. ...
Referential boundary: The target chemical should be classified as Tamoxifen (Hepatotoxicity) Alert OR Thiocarbamates/Sulfides ( ...
Referential boundary: The target chemical should be classified as Perhexiline (Hepatotoxicity) Alert OR Thiocarbamates/Sulfides ...
... is a safener used with maize to protect from chloroacetanilide and thiocarbamate herbicides. It is highly soluble in ... A herbicide safener that protects maize against injury from chloroacetanilide and thiocarbamate herbicides. ...
Structure-guided engineering of molinate hydrolase for the degradation of thiocarbamate pesticides. PLoS ONE, 10(4).*Google ...
... carbamates and thiocarbamates, organophosphates, and synthetic pyrethroids) [7, 8]. Hence, in order to avoid synthetic ...
... thiocarbamate fungicides (methasulfocarb, prothiocarb); thiophene fungicides (ethaboxam, isofetamid, silthiofam); triazine ...
N-di-n-propyl-thiocarbamate (EPTAME); 4-amino-6-t-butyl-3-ethylthio-1,2,4-triazin-5(4H)-one (ETHIOZIN); 2-{4-[(6-chloro-2- ...
Benzofuranes (WSSA Group 16), chlorocarbonic acids (Group 26), phosphorodithioates (Group 8), and thiocarbamates (Group 8) are ... all these effects involves the conjugation of acetyl coenzyme A and other sulfhydryl-containing biomolecules by thiocarbamate ...
Oh Hyuck-Keun: Kinetics and Mechanism of the Aminolysis of Aryl N-Benzyl Thiocarbamates in Acetonitrile. Bulletin of the Korean ... Kinetics and Mechanism of the Aminolysis of Aryl N-Cyclohexyl Thiocarbamates in Acetonitrile. Bulletin of the Korean Chemical ... Oh Hyuck Keun, Park Jie Eun, Sung Dae Dong, Lee Ikchoon: Nucleophilic Substitution Reactions of Aryl N-Phenyl Thiocarbamates ...
... thiocarbamate herbicide (EPTC), metribuzin, imazethapyr and metolachlor.56-62 ,64-75 ,77 ...
In froth flotation, these mediums include xanthates, thiophosphates or thiocarbamates with depressants, including sodium ...
O-(2-naphthyl) N-methyl-N-(1-naphthyl)thiocarbamate. Molecular Formula. C22H17NOS. ...
All the case persons who recalled specific exposures reported exposure to phenoxy herbicides or thiocarbamates. One of them ...
  • Some carbamates, thiocarbamates and carbazides / this publication represents the views of an IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Man, which met in Lyon, 9-15 June 1976. (who.int)
  • In September 2019, under the title "Straightforward access to N-trifluoromethyl amides, carbamates, thiocarbamates and ureas," the scientists present their current research on the importance of amides and related carbonyl derivatives in the natural and biosciences in the internationally esteemed science journal Nature. (rwth-aachen.de)
  • The method relies on the preparation of bench-stable carbamoyl fluoride building blocks, which can be readily diversified to the corresponding N-CF3 amides, carbamates, thiocarbamates, and ureas. (rwth-aachen.de)
  • They represent a large group of different substances (more than 1000 molecules) in relation to their chemical structure, their mode of action and their target: organochlorines, organophosphates, carbamates, thiocarbamates, pyrethroids… In the general population, food is the main one. (cleverlysmart.com)
  • Dithiocarbamates are related to thiocarbamates by the replacement of O by S. Despite this structural similarity their synthesis and chemistry is quite different. (wikipedia.org)
  • A new multicomponent reaction has been developed between isocyanides, sulfur and alcohols or thiols under mild reaction conditions to afford O -thiocarbamates and dithiocarbamates in moderate to good yields. (beilstein-journals.org)
  • Dichlormid is a safener used with maize to protect from chloroacetanilide and thiocarbamate herbicides. (herts.ac.uk)
  • The reaction of readily accessible and bench-stable substituted S -phenyl thiocarbamates and Grignard reactants provides secondary amides. (organic-chemistry.org)
  • Borate, Molybdenum, or Zinc thiocarbamates are also used in metal-to-metal lubrication proposes, mainly as an anti-oxidation or anti-extreme pressure (EP) additive. (wikipedia.org)
  • Propineb is a polymeric zinc-containing Di thiocarbamate. (bighaat.com)
  • 2 R2NH + COS → [R2NH2+][R2NCOS−] In the Newman-Kwart rearrangement O-thiocarbamates can isomerise to S-thiocarbamates. (wikipedia.org)
  • Lloyd-Jones, G. C., Moseley, J. D. & Renny, J. S. Mechanism and application of the Newman-Kwart O→S rearrangement of O -aryl thiocarbamates. (nature.com)
  • In organic chemistry, thiocarbamates (thiourethanes) are a family of organosulfur compounds. (wikipedia.org)
  • 2015). Structure-guided engineering of molinate hydrolase for the degradation of thiocarbamate pesticides . (up.pt)
  • There are 0 terms under the parent term 'Thiocarbamate' in the ICD-10-CM Drugs Index . (icd.codes)
  • O -Thiocarbamates belong to a class of important biologically active molecules, used mainly as fungicides [1-3] in agricultural and pharmaceutical fields. (beilstein-journals.org)
  • She knew lawn mushrooms were a type of fungus, so she wondered if she could kill her lawn mushrooms with foot powder - active ingredient Tolfanate, a synthetic thiocarbamate. (creb.com)
  • Carbon disulfide reacts with the amino groups of amino acids and proteins to form thiocarbamate in blood and tissues (1) thiocarbamates, possessing sulfhydryl groups, may chelate polyvalent inorganic ions. (adhd-npf.com)
  • Thiocarbamate dissociation rates and type of products formed may potentially influence antigenicity and subsequent hypersensitivity/toxic reactions following dNCO exposures. (cdc.gov)
  • The dissociation kinetics of these bis-thiocarbamates, in aqueous conditions, was followed spectrophotometrically under varying pH and temperature conditions. (cdc.gov)
  • Thiocarbamate collectors are also important collectors, and their selectivity is better than that of xanthate collectors and black drug collectors, but the disadvantage is higher cost. (xinhaimining.com)