A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
Out-of-Hospital Cardiac Arrest
The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Emergency Medical Services
Body Temperature Regulation
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Intensive Care Units, Pediatric
Nervous System Diseases
CA1 Region, Hippocampal
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Disease Models, Animal
Intensive Care Units
Circulatory Arrest, Deep Hypothermia Induced
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Randomized Controlled Trials as Topic
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Severity of Illness Index
Evidence supporting the use of therapeutic hypothermia after brain ischemia, however, is limited. A closely related disease to ... This procedure was suggested to be beneficial based on its effects post cardiac arrest. ... Therapeutic hypothermia has been attempted to improve results post brain ischemia. ... Hakim AM (1998). "Ischemic penumbra: the therapeutic window". Neurology. 51 (3 Suppl 3): S44-6. doi:10.1212/wnl.51.3_suppl_3. ...
... more robust defense against hypothermia. The therapeutic potential of irisin is obvious. Exogenously administered irisin ... A beneficial effect of BDNF on neuronal function has been noted in multiple studies. Dr. Pedersen writes, "Neurotrophins are a ... Another potentially important aspect of this work relates to other beneficial effects of exercise, especially in some diseases ... and is seen as having a beneficial impact on health and bodily functioning in most circumstances. P. Munoz-Canoves et al. write ...
Arctic Sun medical device
Therapeutic hypothermia, which lowers the patient's body temperature to levels between 32-34 °C (90-93 °F), is used to help ... Controlled rewarming has been cited in the literature as beneficial in preventing reperfusion injury. Because of the Arctic ... Non-invasively induced therapeutic hypothermia has been shown to reduce mortality of successfully resuscitated cardiac arrest ... Time from cardiac arrest to achieving mild therapeutic hypothermia was equal with both devices (surface, 273 min, core, 270 min ...
The main application of this liquid ventilator is the ultra-fast induction of therapeutic hypothermia after cardiac arrest. ... Although total liquid ventilation (TLV) with completely liquid-filled lungs can be beneficial, the complex liquid-filled tube ... In this regard, a new therapeutic approach is the use of intranasal perfluorochemical spray for preferential brain cooling. The ... 2001). "Rapid (0.5°C/min) minimally invasive induction of hypothermia using cold perfluorochemical lung lavage in dogs". ...
44 (3): 2. Navarette-Opazo, A.; Mitchell, G.S. (2014). "Therapeutic potential of intermittent hypoxia: a matter of dose". Am J ... there is a general consensus in what can be considered a safe and beneficial amount of intermittent hypoxia. Such a protocol ... "Wheel-well Stowaways Risk Lethal Levels of Hypoxia and Hypothermia" (PDF). Human Factors and Aviation Medicine. ... in rats while chronic intermittent hypoxia exposure does Though intermittent hypoxia has been used for various therapeutic ...
Dyskinetic cerebral palsy
Cooling or therapeutic hypothermia for 72 hours immediately after birth has a significant clinical effect on reducing mortality ... However, the responsiveness is less beneficial and the effects are more variable than in patients with inherited or primary ... "Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy". New England Journal of Medicine. 361 (14): 1349-1358. doi: ...
Hypothermia therapy for neonatal encephalopathy
Devices to provide therapeutic Hypothermia Tecotherm Criticool Miracradle: A low cost device designed at the Christian Medical ... Neuroprotective mechanisms need to interact with these mechanisms to have beneficial effect. Newborn hypoxic-ischaemic brain ... 2008). "Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trial". Lancet. 372 ... A 2013 Cochrane review found that therapeutic hypothermia is useful in full term babies with encephalopathy. Studies have been ...
Targeted temperature management
The Hypothermia after Cardiac Arrest Study Group (21 February 2002). "Mild Therapeutic Hypothermia to Improve the Neurologic ... suggests there is no evidence that hypothermia is beneficial.[needs update] As of 2015 hypothermia had shown no improvements in ... Targeted temperature management (TTM) previously known as therapeutic hypothermia or protective hypothermia is an active ... "Therapeutic Hypothermia". eMedicine. 29 June 2010. Cite journal requires ,journal= (help) Krieger, DW; De Georgia, MA; Abou- ...
Potentially neuroprotective trophic factors include CNTF, IGF-1, VEGF, and BDNF Therapeutic hypothermia: This is being explored ... Barreto GE, Iarkov A, Moran VE (2014). "Beneficial effects of nicotine, cotinine and its metabolites as potential agents for ... Sinclair HL, Andrews PJ (2010). "Bench-to-bedside review: Hypothermia in traumatic brain injury". Crit Care. 14 (1): 204. doi: ... Vinpocetine as a unique anti-inflammatory agent may be beneficial for the treatment of neuroinflammatory diseases. It increases ...
Crush syndrome Ischemic stroke Myocardial infarction - Reperfusion Therapeutic hypothermia Hypothermia therapy for neonatal ... Recent investigations suggest a possible beneficial effect of mesenchymal stem cells on heart and kidney reperfusion injury. ... This procedure is called therapeutic hypothermia, and it has been shown by a number of large, high-quality randomised trials to ... For a full review see Hypothermia therapy for neonatal encephalopathy. However, the therapeutic effect of ...
One treatment with some proven benefits is hypothermia, but may be most beneficial in conjunction with pharmacological agents. ... Well-designed clinical trials for stroke treatment in neonates are lacking Recent clinical trials show that therapeutic ... Hypothermia treatment induced by head cooling or systemic cooling administered within 6 hours of birth for 72 hours has proven ... Combined therapies of hypothermia and pharmacological agents or growth factors to improve neurological outcomes are most likely ...
Spinal cord injury research
"Therapeutic Hypothermia: eMedicine Clinical Procedures". Retrieved 2011-02-21. "Hypothermia". Retrieved 2011-02-21. Cappuccino ... have been used to evaluate potentially beneficial effects of localized hypothermia, with and without concomitant ... One experimental treatment, therapeutic hypothermia, is used in treatment but there is no evidence that it improves outcomes. ... Kuchner, E. F.; Hansebout, R. R.; Pappius, H. M. (2000-10-01). "Effects of dexamethasone and of local hypothermia on early and ...
It has recently been discovered that most or all of the therapeutic efficacy of paracetamol is due to a metabolite, AM404, ... However, since opioid antagonists also block the beneficial effects of opioid analgesics, they are generally useful only for ... hypothermia, bradycardia/tachycardia, orthostatic hypotension, dizziness, headache, urinary retention, ureteric or biliary ... Ledeboer A, Hutchinson MR, Watkins LR, Johnson KW (July 2007). "Ibudilast (AV-411). A new class therapeutic candidate for ...
Erythropoietin in neuroprotection
Hypothermia therapy for neonatal encephalopathy is a proven therapy for neonatal brain injury. However, recent research has ... Epo has a lot of potential uses and could provide a therapeutic answer for nervous system injury. However, more studies need to ... These results suggested that RhEpo has both an acute and delayed beneficial action in ischemic spinal cord injury. In contrast ... Research also demonstrates a therapeutic role in modulating neuronal excitability and acting as a trophic factor both in vivo ...
Its beneficial effects in spasticity result from its actions in the brain and spinal cord. Baclofen produces its effects by ... The modulation of the GABAB receptor is what produces baclofen's range of therapeutic properties. Similarly to phenibut (β- ... hypothermia, bradycardia, hypertension, hyporeflexia, coma, and death. Chemically, baclofen is a derivative of the ...
Side effects of penicillin
Destruction of the normal protective flora of beneficial bacteria can occur in dogs and horses. Dogs may have side effects that ... In some instances, this would be an intended therapeutic effect. In other instances, this is an unintended side effect. ... Cats and dogs have had adverse reactions to intravenous penicillin that include: hypothermia, pruritus, hypotension, tremors, ... This side effect may result in an ineffective therapeutic effect of penicillin. When methotrexate is administered with ...
Enhancing elimination of the drug with hemodialysis, hemoperfusion, or forced diuresis is unlikely to be beneficial as these ... Benzodiazepines have a wide therapeutic index and taken alone in overdose rarely cause severe complications or fatalities. More ... hypothermia, hypotension, bradycardia, cardiac arrest, and pulmonary aspiration, with the possibility of death. Severe ... gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse ...
Like with NO, inhalation of H2S has been found to be therapeutic and has been shown to stabilize hypothermia and stabilize ... studies wherein removal of these mediators from plasma were observed and has shown beneficial to mice. When an injury is severe ...
Therapeutic dose dependence is the largest category of people dependent on benzodiazepines. These individuals typically do not ... High single doses or repeated low doses have been reported to produce hypotonia, poor sucking, and hypothermia in the neonate, ... Benzodiazepines are also not beneficial in the treatment of psychosis. The committee also recommended against benzodiazepines ... The differing speed at which tolerance occurs to the therapeutic effects of benzodiazepines can be explained by the speed of ...
Neonatal intensive care unit
Therapies such as prolonged mechanical ventilation, therapeutic hypothermia, neonatal surgery and inhaled nitric oxide are ... Cuddling and skin-to-skin contact, also known as Kangaroo care, are seen as beneficial for all but the frailest (very tiny ... advanced interventions such as extracorporeal membrane oxygenation or hypothermia therapy for neonatal encephalopathy ...
It is not clear of oral ergo alkaloids are beneficial or harmful as they have not been well studied. A 2018 Cochrane Systematic ... Not only did it constrict the uterus, ergot had the ability to increase or decrease blood pressure, induce hypothermia and ... Desgranges joined this remedy into his therapeutic arsenal. From 1777 to 1804 he was successful in alleviating childbirth for ... which was the first transdermal therapeutic system (TTS) in medical history. Their medical recipes have been lost to time, ...
However, soluble mediators of the immune system (growth factors), cell-based therapies and therapeutic chemicals can propagate ... for example those who suffered hypothermia during surgery, are at higher risk for infection. The host's immune response to the ... which can enter the wound site and transform into beneficial wound-healing cells. Since levels of protease inhibitors are ... therapeutic targets and future directions. Paris, France: EUROCONFERENCES. Archived from the original (PDF) on October 27, 2005 ...
THCA:COOH: C22H30O4 (heating/storage) → THC: C21H30O2 → THC-OH: C21H30O3 → THC:COOH: C21H28O4 → profound hypothermia ... and 5/1 have a beneficial effect on patients with asthma, whereas 10/1 have adverse consequences, indicate, that the optimal ' ... have showed promise as therapeutic potential in treating bacterial, fungal, and viral infections, as NAEs also exhibit anti- ... induces profound hypothermia, that is rapid in onset, persistent for 3-4 hours, dose-dependent and is accompanied by a ...
Hypothermia is the reduction of the body's core temperature, causing confusion and trembling. This can occur in malnutrition. ... In Nigeria, the use of imported Ready to Use Therapeutic Food (RUTF) has been used to treat malnutrition in the North. Soy Kunu ... Breastfeeding is noted as one of the most cost effective medical interventions for providing beneficial child health. While ... In young children with severe acute malnutrition it is unclear if ready-to-use therapeutic food differs from a normal diet. ...
Togel, B (2002). "Current therapeutic strategies for hyperhidrosis: a review". Eur J Dermatol. 12 (3): 219-23. PMID 11978559.. ... The duration of the beneficial effect in primary palmar hyperhidrosis has been found to increase with repetition of the ... Episodic with hypothermia (Hines and Bannick syndrome). *Episodic without hypothermia. *Olfactory. *Associated with systemic ... "Current therapeutic strategies for hyperhidrosis: a review". US National Library of Medicine. National Institutes of Health. ...
Gaseous signaling molecules
In 2008, hypothermia induced by hydrogen sulfide for 48 hours was shown to reduce the extent of brain damage caused by ... CO may play a role as potential therapeutic agent. In mammals, carbon monoxide is naturally produced by the action of heme ... However, the issues are complex, as neovascular growth is not always beneficial, since it plays a role in tumor growth, and ... In 2005, it was shown that mice can be put into a state of suspended animation-like hypothermia by applying a low dosage of ...
This use has been approved by the U.S. Food and Drug Administration (FDA). The duration of the beneficial effect in primary ... Togel B1, Greve B, Raulin C. (May-June 2002). "Current therapeutic strategies for hyperhidrosis: a review". US National Library ... Episodic without hypothermia Olfactory Associated with systemic medical problems Parkinson's disease Fibromyalgia Congestive ... Togel, B (2002). "Current therapeutic strategies for hyperhidrosis: a review". Eur J Dermatol. 12 (3): 219-23. PMID 11978559. " ...
... psychosis hypothermia, polyneuropathy, hyperhidrosis. Although hypothermia is usually diagnosed with a body temperature of 35 ° ... 2008 Iwamoto Y, Okuda B, Miyata Y, Tachibana H, Sugita M (June 1994). "[Beneficial effect of steroid pulse therapy on Wernicke- ... because the therapeutic response is often dramatic from the first day, some qualified authors indicate parenteral thiamine if ... Iwamoto Y, Okuda B, Miyata Y, Tachibana H, Sugita M (June 1994). "[Beneficial effect of steroid pulse therapy on Wernicke- ...
Intensive care unit
Such systems are beneficial to intensive care units inorder to ensure correct procedures are being followed for patients ... Therapeutic hypothermia. *Total parenteral nutrition. *Tracheal intubation. Drugs. *Analgesics. *Antibiotics. *Antithrombotics ...
Opioid use disorder
Naloxone is useful for treating an opioid overdose and giving those at risk naloxone to take home is beneficial. In 2013, ... requiring a higher dose to achieve the same therapeutic effect. This points to a potential for greater addictive capacity in ... Head nodding Slurred speech Hypothermia Signs and symptoms of opioid overdose include, but are not limited to: Pin-point pupils ...
Its beneficial effects in spasticity result from its actions in the brain and spinal cord. ... The modulation of the GABAB receptor is what produces baclofen's range of therapeutic properties. ... hypothermia, bradycardia, hypertension, hyporeflexia, coma, and death. ...
Access to therapeutic drug monitoring is important to ensure adequate drug therapeutic level while at the same time preventing ... Treatment with corticosteroids might be most beneficial in those with septic shock and early severe ARDS, whereas its role in ... IV immunoglobulin is not recommended because its beneficial effects are uncertain. Monoclonal and polyclonal preparations of ... loading dose is required to achieve adequate therapeutic level to fight infections. Frequent infusions of beta-lactam ...
Altun A, Ugur-Altun B (May 2007). "Melatonin: therapeutic and clinical utilization". Int. J. Clin. Pract. 61 (5): 835-45. doi: ... A 2016 review found no beneficial role of melatonin in reducing seizure frequency or improving quality of life in people with ... it can cause reduced blood flow and hypothermia.[needs update] In autoimmune disorders, evidence is conflicting whether ... Peres MF, Masruha MR, Zukerman E, Moreira-Filho CA, Cavalheiro EA (April 2006). "Potential therapeutic use of melatonin in ...
Acute respiratory distress syndrome
A compromise between the beneficial and adverse effects of PEEP is inevitable. ... Therapeutic hypothermia. *Total parenteral nutrition. *Tracheal intubation. Drugs. *Analgesics. *Antibiotics. *Antithrombotics ...
There may be an increased risk of hypothermia and peritoneal trauma due to increased exposure to cold, dry gases during ... Based on numerous prospective randomized controlled trials, the approach has proven to be beneficial in reducing post-operative ... The laparoscope aids diagnosis or therapeutic interventions with a few small cuts in the abdomen. ... Peng Y, Zheng M, Ye Q, Chen X, Yu B, Liu B (January 2009). "Heated and humidified CO2 prevents hypothermia, peritoneal injury, ...
a b c d A. B. Stockton, P. T. Pace and M. L. Tainter (1931). "Some clinical actions and therapeutic uses of racemic synephrine ... In mice pre-treated with reserpine,[l] an oral dose of 0.3 mg/kg d-synephrine significantly reversed the hypothermia, while l- ... solutions of the drug to the nasal mucosa of patients with sinusitis did produce a beneficial constriction without local ... Reversal of reserpine-induced hypothermia by a drug is a classical test for potential anti-depressant properties. ...
When long term pain is relieved by therapeutic intervention, scores on the neurotic triad and anxiety fall, often to normal ... Preliminary studies have found medical marijuana to be beneficial in treating neuropathic pain, but not other kinds of long ...
Hypothermia. Immersion foot syndromes Trench foot. Tropical immersion foot. Warm water immersion foot. Chilblains. Frostbite. ... An adverse effect may be termed a "side effect", when judged to be secondary to a main or therapeutic effect. If it results ... and a compromise must be found by the physician and the patient between the beneficial or life-saving consequences of surgery ... Adverse effects, like therapeutic effects of drugs, are a function of dosage or drug levels at the target organs, so they may ...
International Liaison Committee on Resuscitation) (July 2003). "Therapeutic hypothermia after cardiac arrest: an advisory ... Interposed abdominal compressions may be beneficial in the hospital environment. There is no evidence of benefit pre- ... Hypothermia seems to protect by slowing down metabolic and physiologic processes, greatly decreasing the tissues' need for ... "Is oxygen supply a limiting factor for survival during rewarming from profound hypothermia?". American Journal of Physiology. ...
Adverse drug reaction
In Australia, the Therapeutic Goods Administration (TGA) conducts postmarket monitoring of therapeutic products. In the UK the ... Hypothermia. Immersion foot syndromes Trench foot. Tropical immersion foot. Warm water immersion foot. Chilblains. Frostbite. ... as this last expression might also imply that the effects can be beneficial. The study of ADRs is the concern of the field ... or a low therapeutic index of the drug (e.g. nausea from digoxin), and they are therefore predictable. They are dose-related ...
hypothermia, polyneuropathy, hyperhidrosis.. Although hypothermia is usually diagnosed with a body ... Iwamoto Y, Okuda B, Miyata Y, Tachibana H, Sugita M (June 1994). "[Beneficial effect of steroid pulse therapy on Wernicke- ... because the therapeutic response is often dramatic from the first day, some qualified authors indicate parenteral thiamine if ... Iwamoto Y, Okuda B, Miyata Y, Tachibana H, Sugita M (June 1994). "[Beneficial effect of steroid pulse therapy on Wernicke- ...
Treatment of bipolar disorder
As a result, kidney function and blood levels of lithium are monitored in patients being treated with lithium. Therapeutic ... produced positive results. However, since 1999 attempts to confirm this finding of beneficial effects of omega-3 fatty ... Prolonged QT interval, sudden cardiac death, syncope, diabetic ketoacidosis, hypothermia, pancreatitis, Agranulocytosis, ... It was hypothesized that the therapeutic ingredient in omega-3 fatty acid preparations is eicosapentaenoic acid (EPA) and that ...
Hypothermia. Hypothermia can occur. To prevent or treat this, the child can be kept warm with covering including of the ... Improved nutrition, supplementation, ready-to-use therapeutic foods, treating the underlying cause. ... women are often responsible for preparing food and have the chance to educate their children about beneficial food and health ... Schoonees, A; Lombard, M; Musekiwa, A; Nel, E; Volmink, J (Jun 6, 2013). "Ready-to-use therapeutic food for home-based ...
Many wall flowmeters using a Thorpe tube design are able to be dialed to "flush" which is beneficial in emergency situations. ... Typical oxygen masks allow the person to breathe in room air in addition to their therapeutic oxygen, but because filtered ... and hypothermia. ... or a mixture of the preceding into a therapeutic aerosol for ... are the most common gases used to nebulize a bolus or a continuous volume of therapeutic aerosols. ...
He thought that the beneficial effect was due to ultraviolet light killing the bacteria, but recent studies showed that his ... bright light therapy is an excellent candidate for inclusion into the therapeutic inventory available for the treatment of ...
Neonatal intensive care unit
Therapies such as prolonged mechanical ventilation, therapeutic hypothermia, neonatal surgery and inhaled nitric oxide are ... Cuddling and skin-to-skin contact, also known as Kangaroo care, are seen as beneficial for all but the frailest (very tiny ... advanced interventions such as extracorporeal membrane oxygenation or hypothermia therapy for neonatal encephalopathy ...
Lunze K, Bloom DE, Jamison DT, Hamer DH (January 2013). "The global burden of neonatal hypothermia: systematic review of a ... Psychological preparation may be beneficial. Relaxation techniques, immersion in water, massage, and acupuncture may provide ... a source of stem cells for possible therapeutic use". American Journal of Obstetrics and Gynecology. 214 (3): 321-27. doi: ...
ISBN 978-3-540-43957-8. Singh H, Becker PM (August 2007). "Novel therapeutic usage of low-dose doxepin hydrochloride". Expert ... Urinary retention, decreased gastrointestinal motility (paralytic ileus), hyperthermia (or hypothermia), hypertension, dilated ... normalization of the hypothalamic-pituitary-adrenal axis and the circadian sleep-wake cycle may be involved in the beneficial ... Gillman PK (July 2007). "Tricyclic antidepressant pharmacology and therapeutic drug interactions updated". British Journal of ...
While BZD therapeutic effects disappear with tolerance, depression and impulsivity with high suicidal risk commonly persist. ... Withdrawal from long term benzodiazepines is beneficial for most individuals. Withdrawal of benzodiazepines from long-term ... hypothermia, lethargy, and breathing and feeding difficulties. Cases of neonatal withdrawal syndrome have been described in ... Fraser AD (October 1998). "Use and abuse of the benzodiazepines". Therapeutic Drug Monitoring. 20 (5): 481-9. doi:10.1097/ ...
Therapeutic Hypothermia and Temperature Management
Provides a strong multidisciplinary forum to ensure research advances are well disseminated and therapeutic hypothermia is used ... Is Therapeutic Hypothermia Beneficial in All Patients Following Cardiac Arrest? (02/26/2014) ... Therapeutic Hypothermia. and Temperature Management. Editor-in-Chief: W. Dalton Dietrich, III, PhD ... New, Faster Therapeutic Hypothermia Techniques Needed to Optimize Cardioprotection Following a Heart Attack (10/23/2014) ...
Mild Therapeutic Hypothermia During Severe Sepsis
... the safety and the effects on physiological parameters of mild therapeutic hypothe... ... Therapeutic hypothermia is beneficial in children with moderate EAI. It is ineffective in ... ... Therapeutic Hypothermia in Brazil: A MultiProfessional National Survey.. To determine the rate of therapeutic hypothermia (TH) ... Influence of Mild Therapeutic Hypothermia on Leukocyte Count. Mild therapeutic hypothermia is indicated in patients surviving ...
Induced Therapeutic Hypothermia
Induced Therapeutic Hypothermia, Therapeutic Hypothermia, Targeted Temperature Management. ... Pre-hospital cooling has not been shown to be beneficial. *Kim (2013) JAMA 311(1): 45-52 [PubMed] ... Hypothermia) or (induction of), Induced hypothermia, Hypothermia, Therapeutic, Therapeutic Hypothermia, Therapeutic hypothermia ... Induced Therapeutic Hypothermia. Aka: Induced Therapeutic Hypothermia, Therapeutic Hypothermia, Targeted Temperature Management ...
Fluid Shifts in Patients Treated With Therapeutic Hypothermia After Cardiac Arrest - Full Text View - ClinicalTrials.gov
This edema could lead to damage to the same tissue, not beneficial for the patients. We therefore try to evaluate if ... Fluid Shifts in Patients Treated With Therapeutic Hypothermia After Cardiac Arrest. The safety and scientific validity of this ... Therapeutic hypothermia after cardiac arrest har shown to improve the rate of survival in a significant way. However ... Fluid Shift in Patients Treated With Therapeutic Hypothermia After Cardiac Arrest, and How do They Manage Life Afterwards?. ...
Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations
Several studies with TH in experimental models and small clinical trials have shown beneficial effects. Despite this, ... An emerging treatment, therapeutic hypothermia (TH), is a promising neuroprotective therapy in stroke management. ... implementation into the clinical setting is still lacking due to methodological considerations as well as hypothermia-related ... D. Marion and M. R. Bullock, "Current and future role of therapeutic hypothermia," Journal of Neurotrauma, vol. 26, no. 3, pp. ...
Therapeutic Hypothermia After Cardiac Arrest | Circulation
Any potentially beneficial effects of hypothermia on neuronal recovery must be counterbalanced by the known adverse effects of ... The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac ... 19 and reports on the use of hypothermia in treatment of neonatal asphyxia.33-38 The results of therapeutic hypothermia are ... Therapeutic Hypothermia After Cardiac Arrest. Writing Group , J.P. Nolan, P.T. Morley, T.L. Vanden Hoek, R.W. Hickey, Members ...
CPR Flashcards by Fiona Lair | Brainscape
Dietrich WD[au] - PubMed - NCBI
Posttraumatic therapeutic hypothermia alters microglial and macrophage polarization toward a beneficial phenotype. ... Therapeutic hypothermia and targeted temperature management for traumatic brain injury: Experimental and clinical experience. ... Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury.. Wilson NM, Gurney ME, Dietrich WD, ... Ther Hypothermia Temp Manag. 2019 Jun;9(2):97. doi: 10.1089/ther.2019.29059.wdd. Epub 2019 May 23. No abstract available. ...
Frontiers | Therapeutic Hypothermia in Stroke and Traumatic Brain Injury | Neurology
The efficacy of hypothermia in acute ischemic stroke (AIS) and traumatic brain injury (TBI), however, is not well studied. ... The efficacy of hypothermia in acute ischemic stroke (AIS) and traumatic brain injury (TBI), however, is not well studied. ... Among the various methods for hypothermia induction, intravascular cooling (IVC) may have the most promise in the awake patient ... Among the various methods for hypothermia induction, intravascular cooling (IVC) may have the most promise in the awake patient ...
JCI - Myocardial ischemia-reperfusion injury: a neglected therapeutic target
Therapeutic hyperoxemia and hypothermia. Two other mechanical interventions that have been reported in animal studies to be ... beneficial against myocardial reperfusion injury include therapeutic hyperoxemia (78) and hypothermia (79). Hyperbaric oxygen ... Therapeutic strategies for reducing acute myocardial ischemic injury * Therapeutic strategies for reducing myocardial ... Therapeutic strategies for reducing acute myocardial ischemic injury * Therapeutic strategies for reducing myocardial ...
Brain ischemia - Wikipedia
Evidence supporting the use of therapeutic hypothermia after brain ischemia, however, is limited. A closely related disease to ... This procedure was suggested to be beneficial based on its effects post cardiac arrest. ... Therapeutic hypothermia has been attempted to improve results post brain ischemia. ... Hakim AM (1998). "Ischemic penumbra: the therapeutic window". Neurology. 51 (3 Suppl 3): S44-6. doi:10.1212/wnl.51.3_suppl_3. ...
Cooling may benefit children after card... ( NEW YORK (December 3 2009) -- When t...)
Cardiac Arrest and Therapeutic Hypothermia. During cardiac arrest, the bodys blood supply is interrupted and cells are ... The therapy has been used successfully in adult cardiac arrest patients, and has been shown beneficial for newborns who have ... Therapeutic hypothermia, a treatment in which the patients body temperature is lowered and maintained several degrees below ... "In this new study, we aim to show that therapeutic hypothermia can give these children a better chance at survival and long- ...
Therapeutic Hypothermia - Cooling therapy protects brain after cardiac arrest
The therapy has been used successfully in adult cardiac arrest patients, and has been beneficial for newborns, who have ... Therapeutic Hypothermia - Cooling therapy protects brain after cardiac arrest. Dec 7, 2009 - 3:21:13 PM ... In this new study, we aim to show that therapeutic hypothermia can give these children a better chance at survival and long- ... Therapeutic hypothermia slows the bodys production of these compounds, reducing risk for brain injury. ...
Cerebral ischemia : Wikis (The Full Wiki)
Application of Mild Therapeutic Hypothermia on Stroke: A Systematic Review and Meta-Analysis
There were previous reports of strong beneficial effects of hypothermia-induced neuroprotection in cerebral ischemia, reducing ... Regardless of the technique, therapeutic hypothermia was defined as the body temperature of 33-34°C (mild hypothermia) and ... Application of Mild Therapeutic Hypothermia on Stroke: A Systematic Review and Meta-Analysis. Shaheen E. Lakhan and Fabricio ... K. Z. Guluma, T. M. Hemmen, S. E. Olsen, K. S. Rapp, and P. D. Lyden, "A trial of therapeutic hypothermia via endovascular ...
Circulation | COVID-19 | Page 2
Postresuscitation hemodynamics during therapeutic hypothermia after out-of-hospital cardiac arrest with ventricular ... For any other rhythm, or cardiac arrest inhospital, such cooling may also be beneficial. ... Outcome, timing and adverse events in therapeutic hypothermia after out-of-hospital cardiac arrest. ... Reduced intravascular volume during hypothermia is by 10- 35%. Lower heart rate is associated with good one-year outcome in ...
Efficacy of Therapeutic Hypothermia Examined in Traumatic Brain Injuries - MPR
... therapeutic hypothermia is beneficial, according to a meta-analysis published online December 9 in Critical Care Medicine. ... "Therapeutic hypothermia is likely a beneficial treatment following traumatic brain injuries in adults but cannot be recommended ... HealthDay News - For adults, but not children, with traumatic brain injuries, therapeutic hypothermia is beneficial, according ... Avoiding Profound Hypothermia Improves Functions After Initial Reperfusion. *Therapeutic Hypothermia May Help Cardiac Arrest ...
Neonatal Cerebral Air Embolism
Study questions hypothermia treatment for card... ( Therapeutic hypothermia cooling the...)
... hypothermia,treatment,for,cardiac,arrest,medicine,medical news today,latest medical news,medical newsletters,current medical ... Therapeutic hypothermia cooling the body and brain down to 33C is th... Our results show that it is just as effective both for ... to analyse the patient data in more detail to see if there may be groups of patients for whom cooling could be beneficial and ... Study questions hypothermia treatment for cardiac arrest. ...Therapeutic hypothermia cooling the body and brain down to 33C is ...
Hypothermia, Induced | Profiles RNS
Jehle D, Meyer M, Gemme S. Beneficial response to mild therapeutic hypothermia for comatose survivors of near-hanging. Am J ... The feasibility of inducing mild therapeutic hypothermia after cardiac resuscitation using iced saline infusion via an ... The effect of ambient temperature on cold saline during simulated infusion to induce therapeutic hypothermia. Resuscitation. ... Rivera-Lara L, Zhang J, Muehlschlegel S. Therapeutic hypothermia for acute neurological injuries. Neurotherapeutics. 2012 Jan; ...
December 2016 Briefing - Pediatrics --Doctors Lounge
Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model - RMIT Research Repository
... anti-inflammatory and sympatholytic properties that may be beneficial for perinatal asphyxia. The optimal safe dose for pre- ... Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model. Ezzati, M, Broad, K, ... Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model ... Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model, Acta Anaesthesiologica ...
Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients
Internet Scientific Publications
If elevated ICP cannot be controlled, induced barbiturate coma or therapeutic hypothermia may be instituted. However, these ... The beneficial effect of sustained. hyperventilation on ICP is unresolved and has not been systematically examined in this ... A therapeutic goal for all treatment of elevated ICP is ICP 70 mm Hg37. Optimal head position can be adjusted according to CPP ... Hypothermia may be neuroprotective and decreases ICP by lowering cerebral blood volume (by lowering metabolic demand). ...
Neuroprotection and Hypothermia in Infants and Children | Bentham Science
Current evidence supports the use of therapeutic hypothermia (TH) in unconscious patients after out-of-hospital cardiac arrest ... TH has been proved to be also beneficial in term neonates after hypoxic-ischemic encephalopathy (HIE) and in children with ... Current evidence supports the use of therapeutic hypothermia (TH) in unconscious patients after out-of-hospital cardiac arrest ... Neuroprotection and Hypothermia in Infants and Children. Author(s): Domenico Pietrini, Neuroanestesia Pediatrica, Terapia ...
Search results for `propensity score methods` - PhilPapers
Up to now, no large observational studies have confirmed the beneficial effects of mild therapeutic hypothermia. DESIGN: ... The adjusted odds ratio of the hospital mortality of patients treated after implementation of mild therapeutic hypothermia was ... METHODS: The moment of implementation of mild therapeutic hypothermia for each hospital participating in the Dutch National ... To compare mortality before and after implementation of mild therapeutic hypothermia, the odds ratio adjusted for Simplified ...
Cardiopulmonary Resuscitation (CPR) in Infants and Children - Critical Care Medicine - Merck Manuals Professional Edition
... there is no evidence that therapeutic hypothermia is beneficial. In comatose children resuscitated from cardiac arrest, ... 1. Moler FW, Silverstein FS, Holubkov R, et al: Therapeutic hypothermia after in-hospital cardiac arrest in children. N Engl J ... 2. Moler FW, Silverstein FS, Holubkov R, et al: Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N ... therapeutic normothermia (36° C to 37.5° C) should be pursued (1, 2) and fever should be treated aggressively. ...
Pharmacokinetics of Ampicillin in Neonates With Moderate to Severe Hypoxic-Ischemic Encephalopathy - Full Text View -...
Controlled hypothermia (CH) has been accepted as a neuroprotective therapeutic modality for neonates with moderate to severe ... Neonates exhibit varying degrees of multiorgan dysfunction after a hypoxic-ischemic insult, although the added beneficial and ... Hypothermia. Central Nervous System Diseases. Nervous System Diseases. Body Temperature Changes. Signs and Symptoms. ... Controlled Hypothermia has become the standard of care for neonates with moderate to severe HIE. Ampicillin and aminoglycosides ...
post-resuscitation care - Signa Vitae
Effects of therapeutic hypothermia and kinetics of serum protein S100B after cardiopulmonary resuscitation. By Ákos Mérei, ... Despite recommendations of international guidelines, we cannot prove the beneficial effect of TH, or a correlation of protein ... A milestone of these is the application of therapeutic hypothermia (TH). The aims of our study were: to determine the 30-day- ... Key words: cardiac arrest, cardiopulmonary resuscitation, post-resuscitation care, therapeutic hypothermia, protein S100B ...
Cardiac Literature, including Myocardial Infarction, arrthymias, tachycardia, and angina sub-cluster 53
Mild therapeutic hypothermia has been shown to improve outcome for patients after cardiac arrest and may be beneficial for ... Hypothermia is usually chosen to preserve the brain in case of failure of oxygen delivery whatever it may result from. Nowadays ... OBJECT: Hypothermia is protective in stroke models, but findings from permanent occlusion models are conflicting. In this ... Hypothermia preserves myocardial function, promotes signaling for cell survival, and inhibits apoptotic pathways during 45-min ...
EncephalopathyNormothermiaOutcomeNeuroprotectionVentricular fibrillationInfantsOutcomesModified neonatalClinicalTotal-body hypothermiaEfficacyPerinatalTemperature ManagementSurvivalInterventionTraumatic BrainModerateEffect of hypothermiaApplication of therapeutic hypothermiaEffectiveness of therapeutic hypothermiaComatose survivorsReturn of spontaneous circulationHypoxiaAcuteTrialsTreated with induced hypothermiaPathophysiologySystemicMyocardialImpact of hypothermiaSystematic ReviewTreatmentProvided a neuroprotective effectStrokeNewbornsInduceEffectsResuscitation from cardiac arrestBODY TEMPERATUREAdverseHypoxic-ischaemic
- Can cerebellar and brainstem apparent diffusion coefficient (ADC) values predict neuromotor outcome in term neonates with hypoxic-ischemic encephalopathy (HIE) treated with hypothermia? (umassmed.edu)
- TH has been proved to be also beneficial in term neonates after hypoxic-ischemic encephalopathy (HIE) and in children with traumatic brain injury (TBI). (eurekaselect.com)
- Therapeutic hypothermia is now the standard of care for hypoxic-ischemic encephalopathy. (aappublications.org)
- Neuroprotective body hypothermia among newborns with hypoxic ischemic encephalopathy: three-year experience in a tertiary university hospital. (scielo.br)
- There is evidence from the 11 randomised controlled trials included in this systematic review (N = 1505 infants) that therapeutic hypothermia is beneficial in term and late preterm newborns with hypoxic ischaemic encephalopathy. (nih.gov)
- Hypothermia should be instituted in term and late preterm infants with moderate-to-severe hypoxic ischaemic encephalopathy if identified before six hours of age. (nih.gov)
- Data from large randomized clinical trials indicate that therapeutic hypothermia, using either selective head cooling or systemic cooling, is an effective therapy for neonatal encephalopathy. (aappublications.org)
- In 2005, the National Institute of Child Health and Human Development (NICHD) convened a workshop to evaluate the status of knowledge regarding the safety and efficacy of hypothermia as a neuroprotective therapy for neonatal hypoxic-ischemic encephalopathy. (aappublications.org)
- 4 After showing consistent benefit in animal models, the safety, feasibility, and practicality of using induced hypothermia in infants who have neonatal encephalopathy were investigated in several small studies. (aappublications.org)
- Six large randomized clinical trials of induced hypothermia for neonatal encephalopathy were published from 2005 to 2011. (aappublications.org)
- Three large multicenter randomized studies of newborn infants with hypoxic ischemic encephalopathy suggest a beneficial effect in this patient population. (springeropen.com)
- Therefore, hypothermia treatment is the standard of care when a diagnosis of hypoxic ischemic encephalopathy has been made. (abclawcenters.com)
- Throughout this page, our HIE and hypothermic brain cooling attorneys will explain everything you need to know about hypoxic ischemic encephalopathy, hypothermia therapy and birth injury. (abclawcenters.com)
- Allopurinol or placebo will be given in addition to therapeutic hypothermia (where indicated) to infants with a gestational age ≥ 36 weeks and a birth weight ≥ 2500 g, with severe perinatal asphyxia and potentially evolving encephalopathy. (biomedcentral.com)
- The selective α2-adrenoreceptor agonist dexmedetomidine has shown neuroprotective, analgesic, anti-inflammatory, and sympatholytic properties that may be beneficial in neonatal encephalopathy (NE). (bvsalud.org)
- Hypothermia is a standard treatment for neonatal encephalopathy, but nearly 50% of treated infants have adverse outcomes. (frontiersin.org)
- In 2002 the results of 2 prospective randomized trials were published that compared mild hypothermia with normothermia in comatose survivors of out-of-hospital cardiac arrest. (ahajournals.org)
- In the European study, the median Glasgow Coma Scale score on hospital admission in both groups was 3 with an interquartile range of 3 to 5 in the group with normothermia and 3 to 4 in the group with hypothermia. (ahajournals.org)
- In the European study, 75 of the 136 patients (55%) in the hypothermia group for whom data were available had a favorable neurological outcome (able to live independently and work at least part-time) at 6 months compared with 54 of 137 (39%) in the normothermia group (relative risk [RR] 1.40, 95% CI 1.08 to 1.81, number needed to treat [NNT]=6]. (ahajournals.org)
- 19 At 6 months there were 56 deaths in the 137 participants (41%) in the hypothermia group versus 76 of 138 (55%) in the normothermia group (RR 0.74, 95% CI 0.58 to 0.95, NNT=7). (ahajournals.org)
- 0.65-0.93,pared therapeutic hypothermia to normothermia for new- respectively).borns with HIE. (slideshare.net)
- A matching process based on the propensity score was performed to equalize potential prognostic factors in the hypothermia and normothermia groups, and to formulate a balanced 1:1 matched cohort study. (biomedcentral.com)
- There was no significant difference in the rate of favorable neurological outcome between the hypothermia-matched group and the normothermia-matched group. (biomedcentral.com)
- Bernard et al 6 studied 77 patients with out of hospital cardiac arrests who were each randomly assigned to care with normothermia or hypothermia (core body temperature reduced to 33°C within 2 hours of the return of spontaneous circulation and maintained at that temperature for 12 hours). (ispub.com)
- Some 49% of their patients treated with hypothermia were considered to have a 'good' outcome (ie discharged to home or rehabilitation facility) whilst only 26% of those in the normothermia group had the same outcome (P=0.046) . (ispub.com)
- A multicentre study by the Hypothermia After Cardiac Arrest Study Group demonstrated a 55% favourable outcome in the hypothermia group (32°C to 34°C, as measured in the bladder, for 24 hours) compared with 39% of those treated with normothermia following cardiac arrest 7 . (ispub.com)
- It is possible that therapeutic normothermia or the avoidance of hyperthermia provides the bulk of the benefit seen in prior studies of cardiac arrest survivors. (touchneurology.com)
- 2002). Both trials showed improved neurological outcomes with hypothermia between 32° and 34° compared to normothermia after cardiac arrest in shockable rhythm. (healthmanagement.org)
- HYPERION is a multicenter (22 French ICUs) trial with blinded outcome assessment in which 584 patients with successfully resuscitated nonshockable cardiac arrest are allocated at random to either TTM between 32.5 and 33.5°C (therapeutic hypothermia) or TTM between 36.5 and 37.5°C (therapeutic normothermia) for 24 hours. (biomedcentral.com)
- Both groups are managed with therapeutic normothermia for the next 24 hours. (biomedcentral.com)
- The first randomized trial was a European multicenter study in 275 patients managed with normothermia or hypothermia [ 7 ]. (biomedcentral.com)
- Kees H., Polderman M.D. Therapeutic hypothermia and cont-rolled normothermia in the intensive care unit: Practical consi-derations, side effects, and cooling methods. (org.ua)
- Inducibility of VF was studied by programmed ventricular stimulation three times in each animal under the following: during normothermia (NT), after reaching the core temperature of 32°C (HT) and after another 60 minutes of stable hypothermia (HT60). (biomedcentral.com)
- The review found no significant difference between hypothermia and normothermia in rates of mortality. (neurocirurgiabr.com)
- In a meta-analysis of RCTs of any quality, the review found that hypothermia reduced the risk of unfavourable outcomes compared with normothermia. (neurocirurgiabr.com)
- They were randomised to therapeutic hypothermia (target temperature, 33.0°C) or therapeutic normothermia (target temperature, 36.8°C) within 6 hours after the return of circulation. (extrememember.com)
- Therapeutic hypothermia, as compared with therapeutic normothermia, did not confer a significant benefit with respect to survival with good functional outcome at 1 year, and survival at 12 months did not differ significantly between the treatment groups. (extrememember.com)
- In comatose children who survived out-of-hospital cardiac arrest, therapeutic hypothermia, as compared with therapeutic normothermia, did not confer a significant benefit in survival with a good functional outcome at 1 year. (extrememember.com)
- In a randomized, controlled trial, we compared the effects of moderate hypothermia and normothermia in patients who remained unconscious after resuscitation from out-of-hospital cardiac arrest. (hipotermiaterapeutyczna.pl)
- METHODS: The study subjects were 77 patients who were randomly assigned to treatment with hypothermia (with the core body temperature reduced to 33 degrees C within 2 hours after the return of spontaneous circulation and maintained at that temperature for 12 hours) or normothermia. (hipotermiaterapeutyczna.pl)
- RESULTS: The demographic characteristics of the patients were similar in the hypothermia and normothermia groups. (hipotermiaterapeutyczna.pl)
- Twenty-one of the 43 patients treated with hypothermia (49 percent) survived and had a good outcome-that is, they were discharged home or to a rehabilitation facility-as compared with 9 of the 34 treated with normothermia (26 percent, P=0.046). (hipotermiaterapeutyczna.pl)
- METHODS: In this multicenter trial with blinded assessment of the outcome, patients who had been resuscitated after cardiac arrest due to ventricular fibrillation were randomly assigned to undergo therapeutic hypothermia (target temperature, 32 degrees C to 34 degrees C, measured in the bladder) over a period of 24 hours or to receive standard treatment with normothermia. (hipotermiaterapeutyczna.pl)
- While moderate hypothermia (28-32°C) is technically difficult and fraught with complications, recent experimental studies have shown that small decreases in the core temperature (from normothermia to 33-36°C) are safe and sufficient to reduce neuronal death. (americorpshealth.biz)
- Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis. (bioportfolio.com)
- Therapeutic hypothermia (TH) is considered to improve survival with favorable neurological outcome in the case of global cerebral ischemia after cardiac arrest and perinatal asphyxia. (frontiersin.org)
- Outcome, timing and adverse events in therapeutic hypothermia after out-of-hospital cardiac arrest. (esicm.org)
- Recent trials have failed to demonstrate a beneficial outcome from therapeutic treatments such as corticosteroids, hypothermia and hypertonic saline. (ebscohost.com)
- Despite recommendations of international guidelines, we cannot prove the beneficial effect of TH, or a correlation of protein S100B levels with a positive outcome. (signavitae.com)
- Mild hypothermia (32-34_ C) induced after arrival at the receiving hospital, appears to have balanced a positive outcome with acceptable complications. (jems.com)
- Hypothermia after Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. (jems.com)
- 1 Therapeutic hypothermia has been shown to improve survival and neurodevelopmental outcome. (aappublications.org)
- 6 Experimental studies have shown that the benefit of cooling is maximal the sooner it is commenced, 7 and the Total Body Hypothermia (TOBY) trial showed a trend to improved outcome in infants cooled within 4 hours of delivery. (aappublications.org)
- Most previous reports have examined the differences between shockable and non-shockable rhythms in terms of neurological outcome and mortality rates after therapeutic hypothermia. (clinicaltrials.gov)
- number needed to treat for an additional beneficial outcome (NNTB) 7 (95% CI 5 to 10) (8 studies, 1344 infants). (nih.gov)
- There are more studies published During the last 2 decades, evidence from since the previous reviews.20-22 The pri- experimental and clinical studies sug- mary objective of this review was to use gests that therapeutic hypothermia re- all the available data, including those from duces cerebral injury and improves neu- the most recently published randomized rological outcome. (slideshare.net)
- Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. (springeropen.com)
- Although efficacy of hypothermia in improving functional outcome of mild to moderate traumatic SCI has been demonstrated, hypothermia may not be protective against severe traumatic SCI. (curehunter.com)
- The primary outcomes were survival and favorable neurologic outcome at discharge associated with the therapeutic hypothermia protocol. (hollos.net)
- In adjusted analysis, ventricular fibrillation patients during the therapeutic hypothermia period trended toward improved survival (odds ratio = 1.71, 95% confidence interval = 0.85-3.46) and had favorable neurologic outcome (odds ratio = 2.62, 95% confidence interval = 1.1-6.27) compared with the earlier period. (hollos.net)
- The only established therapy to improve outcome in these infants is therapeutic hypothermia. (biomedcentral.com)
- Allopurinol is a xanthine oxidase inhibitor that reduces the production of oxygen radicals as superoxide, which contributes to secondary energy failure and apoptosis in neurons and glial cells after reperfusion of hypoxic brain tissue and may further improve outcome if administered in addition to therapeutic hypothermia. (biomedcentral.com)
- In different models of focal and global cerebral ischemia, mild-to-moderate hypothermia reduces mortality and neuronal injury and improves neurological outcome. (ox.ac.uk)
- Mild therapeutic hypothermia (MTH) is being used after cardiac arrest for its expected improvement in neurological outcome. (biomedcentral.com)
- Studies in laboratory animals suggest that hypothermia induced shortly after the restoration of spontaneous circulation may improve neurologic outcome, but there have been no conclusive studies in humans. (hipotermiaterapeutyczna.pl)
- CONCLUSIONS: In patients who have been successfully resuscitated after cardiac arrest due to ventricular fibrillation, therapeutic mild hypothermia increased the rate of a favorable neurologic outcome and reduced mortality. (hipotermiaterapeutyczna.pl)
- A study conducted in 2002-2004 showed that treatment with therapeutic hypothermia for patients resuscitated after cardiac arrest due to ventricular fibrillation led to a positive outcome (Glasgow-Pittsburgh Cerebral Performance category 1 or 2) in 24 of 43 patients compared to only 11 of 43 patients in the standard resuscitation group where no hypothermia was used in treatment. (wikipedia.org)
- Non-invasively induced therapeutic hypothermia has been shown to reduce mortality of successfully resuscitated cardiac arrest victims by 35 percent and increase the chance of a good neurologic outcome by 39 percent. (wikipedia.org)
- Therapeutic hypothermia is promising in clinical settings for stroke neuroprotection. (hindawi.com)
- More importantly, these findings led to the realization that hypothermia-induced neuroprotection is not only limited to decreased oxygen and glucose demands, but the mechanisms involved are indeed much more intricate. (springeropen.com)
- 7. Holzer M, Bernard SA, Hachimi-Idrissi S, Roine RO, Sterz F, Mullner M. Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis. (prelekara.sk)
- The aim was to assess whether hypothermia + dexmedetomidine treatment augments neuroprotection compared to routine treatment (hypothermia + fentanyl sedation) in a piglet model of NE using magnetic resonance spectroscopy (MRS) biomarkers, which predict outcomes in babies with NE, and immunohistochemistry. (bvsalud.org)
- Pharmacological therapies can act through complementary mechanisms with hypothermia improving neuroprotection. (frontiersin.org)
- 2010). „Cochrane corner: hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. (hipotermiaterapeutyczna.pl)
- Neuroprotection associated with xenon has been especially evident when combined with hypothermia (91.4°F to 95°F). Thus far, these neuroprotective properties have not been reported in human studies. (medicalxpress.com)
- Mild therapeutic hypothermia is indicated in patients surviving out-of-hospital cardiac arrest due to ventricular fibrillation. (bioportfolio.com)
- Current evidence supports the use of therapeutic hypothermia (TH) in unconscious patients after out-of-hospital cardiac arrest when the initial heart rhythm was ventricular fibrillation. (eurekaselect.com)
- In both trials, therapeutic hypothermia significantly improved the neurological outcomes of patients with cardiac arrest in shockable rhythms (ventricular fibrillation or pulseless ventricular tachycardia). (biomedcentral.com)
- To evaluate whether implementation of a therapeutic hypothermia protocol on arrival in a community hospital improved survival and neurologic outcomes in patients initially found to have ventricular fibrillation, pulseless electrical activity, or asystole, and then successfully resuscitated from out-of-hospital cardiac arrest. (hollos.net)
- Survival to hospital discharge improved in the therapeutic hypothermia period in patients with an initial rhythm of ventricular fibrillation (odds ratio = 1.88, 95% confidence interval = 1.03-3.45), however not in patients with nonventricular fibrillation (odds ratio = 1.17, 95% confidence interval = 0.66-2.05). (hollos.net)
- The therapeutic hypothermia period was associated with a significant improvement in neurologic outcomes in patients whose initial rhythm was ventricular fibrillation, but not in patients with other rhythms. (hollos.net)
- Mild therapeutic hypothermia has proved beneficial after out-of-hospital cardiac arrest in the adult population, when the initial rhythm is ventricular fibrillation (VF). (bgu.ac.il)
- We studied whether mild systemic hypothermia increases the rate of neurologic recovery after resuscitation from cardiac arrest due to ventricular fibrillation. (hipotermiaterapeutyczna.pl)
- RESULTS AND CONCLUSION: Although proven beneficial only for patients with initial ventricular fibrillation (GOR A), the SSAITFTH also recommend MTH after restored spontaneous circulation, if active treatment is chosen, in patients with initial pulseless electrical activity and asystole (GOR D). Normal ethical considerations, premorbid status, total anoxia time and general condition should decide whether active treatment is required or not. (lsh.is)
- Animal models suggest that neuroprotective effects of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. (bioportfolio.com)
- This was a retrospective observational study of 143 infants referred to a regional NICU for ongoing therapeutic hypothermia. (aappublications.org)
- 2 In the United Kingdom, both the National Institute for Health and Clinical Excellence and the British Association of Perinatal Medicine issued guidance on the provision of therapeutic hypothermia for infants with HIE. (aappublications.org)
- In the East of England, the Acute Neonatal Transfer Service (ANTS) first transferred infants for therapeutic hypothermia to 1 of the 3 network NICUs in June 2009. (aappublications.org)
- Thirty-nine infants fulfilled the hypothermia protocol criteria. (scielo.br)
- Newborn animal studies and pilot studies in humans suggest that mild hypothermia following peripartum hypoxia-ischaemia in newborn infants may reduce neurological sequelae without adverse effects. (nih.gov)
- To determine the effect of therapeutic hypothermia in encephalopathic asphyxiated newborn infants on mortality, long-term neurodevelopmental disability and clinically important side effects. (nih.gov)
- We included randomised controlled trials comparing the use of therapeutic hypothermia with standard care in encephalopathic term or late preterm infants with evidence of peripartum asphyxia and without recognisable major congenital anomalies. (nih.gov)
- Neuronal rescue of encephalopathic newborn infants using induced hypothermia is one of the few therapeutic modalities in neonatology that was studied extensively in animal models before clinical application in humans. (aappublications.org)
- The study showed that hypothermia did not significantly reduce the rate of mortality or severe disability but resulted in improved neurologic outcomes in infants assessed at 18 months of age. (springeropen.com)
- Despite treatment with hypothermia, some infants with neonatal HIE present adverse outcomes. (frontiersin.org)
- However, with and without therapeutic hypothermia, many infants with HIE go on to develop permanent health conditions and disorders. (hiehelpcenter.org)
- Among the various methods for hypothermia induction, intravascular cooling (IVC) may have the most promise in the awake patient in terms of clinical outcomes. (frontiersin.org)
- A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI. (jci.org)
- Patients undergoing post-cardiac arrest therapeutic hypothermia have better neurological outcomes if their initial arrest rhythm is pulseless electrical activity (PEA) in comparison to asystole. (clinicaltrials.gov)
- In 2002, two randomized controlled trials were published showing an improvement in neurological outcomes in patients treated with mild therapeutic hypothermia post resuscitation from shockable cardiac arrest. (clinicaltrials.gov)
- Some have reported improved mortality and better neurological outcomes with therapeutic hypothermia in this patient population. (clinicaltrials.gov)
- To audit survival and neurological recovery outcomes in patients treated with induced hypothermia within the Intensive Care Unit (ICU) following cardiac arrest. (ispub.com)
- This audit was conducted to review the cases of cardiac arrest presenting to, or occurring in, St Peter's Hospital in 2009-10 in order to assess the neurological outcomes of patients who were cooled on the ICU, and to determine whether therapeutic hypothermia should be implemented as standard care following cardiac arrest, or, if not, in which cases it would be most beneficial. (ispub.com)
- This audit has been based on the findings of two papers, both of which demonstrated a significant improvement in long term neurological outcomes for patients following induced hypothermia. (ispub.com)
- They demonstrated that treatment with moderate hypothermia improved outcomes in patients with coma after resuscitation from an out-of-hospital cardiac arrest. (ispub.com)
- It took nearly half a century, from 1957 to 2002, for therapeutic hypothermia to acquire its current status as a key intervention for improving neurological outcomes in survivors of cardiac arrest. (healthmanagement.org)
- 2013) failed to demonstrate any difference in neurological outcomes or survival between hypothermia at 33° and hypothermia at 36°C. The results of the TTM trial complicate the interpretation of another preliminary study showing better outcomes with hypothermia at 32°C compared to 34°C (Lopezde-Sa et al. (healthmanagement.org)
- Therapeutic Hypothermia patients failed to demonstrate a significant benefit in terms of improved neurological outcomes. (prelekara.sk)
- As therapeutic hypothermia is only partially effective, adjunct therapies are needed to optimize outcomes. (bvsalud.org)
- Traumatic brain injury (TBI) is a worldwide medical problem, and currently, there are few therapeutic interventions that can protect the brain and improve functional outcomes in patients. (braincirculation.org)
- Therapeutic hypothermia and targeted temperature management protocols over the last several decades have demonstrated successful reduction of secondary injury mechanisms and, in some selective cases, improved outcomes in specific TBI patient populations. (braincirculation.org)
- However, the benefits of therapeutic hypothermia have not been demonstrated in multicenter randomized trials to significantly improve neurological outcomes. (braincirculation.org)
- We recently found evidence that HEMS exerts beneficial effects on outcomes for severely injured patients. (uni-frankfurt.de)
- CONCLUSIONS: Our preliminary observations suggest that treatment with moderate hypothermia appears to improve outcomes in patients with coma after resuscitation from out-of-hospital cardiac arrest. (hipotermiaterapeutyczna.pl)
- In the 1980s, the use of hypothermia on dogs after cardiac arrest demonstrated positive outcomes including neurological status and survival. (wikipedia.org)
- A combination of mild hypothermia and sevoflurane affords long-term protection in a modified neonatal mouse model of cerebral hypoxia-ischemia. (umassmed.edu)
- Several studies with TH in experimental models and small clinical trials have shown beneficial effects. (hindawi.com)
- Despite this, implementation into the clinical setting is still lacking due to methodological considerations as well as hypothermia-related complications. (hindawi.com)
- Therapeutic hypothermia and targeted temperature management for traumatic brain injury: Experimental and clinical experience. (nih.gov)
- The major advantage of external cooling is that it does not require advanced equipment to induce hypothermia but often requires many hours to reach target temperature and increases the chance of clinical complications such as shivering, pneumonia, and reactive brain edema (due to temperature overshooting). (hindawi.com)
- By analyzing research methods and difficulties extrapolating from stroke models to clinical disease, we identify ways to improve therapeutic development. (ajnr.org)
- should consider offering therapeutic hypothermia as part of routine clinical care to these newborns.Results: Seven trials including 1214 newborns were iden-tified. (slideshare.net)
- 3 The purpose of this clinical report is to review briefly the current knowledge regarding the efficacy and safety of therapeutic hypothermia, to point out major gaps in knowledge that were identified at the 2010 workshop, and to suggest a framework for the implementation of hypothermia. (aappublications.org)
- However, despite our clinical and experimental experiences, the protective molecular mechanisms of therapeutic hypothermia remain to be elucidated. (springeropen.com)
- Therefore, in this brief overview we discuss both the clinical evidence and molecular mechanisms of therapeutic hypothermia in order to provide further insights into this promising intervention. (springeropen.com)
- Following two previous clinical trials 3,4 showing a significant benefit of mild therapeutic hypothermia after out-of-hospital cardiac arrest, one can make a plausible argument that the benefit seen for cardiac arrest patients may also apply to acute ischemic stroke patients. (touchneurology.com)
- Understanding how human cells in tissue culture adapt to hypothermia may aid in developing new clinical procedures for improved ischemic and hypothermic protection. (biomedcentral.com)
- Hypothermia is utilized in several clinical situations. (biomedcentral.com)
- Unfortunately, both the protective and harmful mechanisms induced by hypothermia vary with temperature and are poorly understood and therefore its clinical utility remains limited. (biomedcentral.com)
- Kalenova I.E., Sharinova I.A., Shevelev O.A., Butrov A.V. An experience of clinical application of hypothermia in ischemic stroke treatment. (org.ua)
- Although the exact reasons underlying the inability to translate therapeutic hypothermia into a larger clinical population are unknown, this failure may reflect the suboptimal use of this potentially powerful therapeutic in potentially treatable severe trauma patients. (braincirculation.org)
- It is known that multiple factors including patient recruitment, clinical treatment variables, and cooling methodologies are all important in yielding beneficial effects. (braincirculation.org)
- Experimental evidence suggests that therapeutic hypothermia is beneficial, and a number of clinical studies on this subject have been published. (hipotermiaterapeutyczna.pl)
- Hypothermia can protect against multiple deleterious processes, including oxidative stress, inflammation, lipid peroxidation, and activation of cysteine or serine proteases.88-94 Each degree of temperature decline reduces the rate of cellular respiration, oxygen demand, carbon dioxide production by 10%.95 Preclinical and clinical results have been encouraging, making hypothermia an attractive physiological therapy that targets multiple injury mechanisms. (americorpshealth.biz)
- In 1952 at the University of Minnesota, Dr. John Lewis closed an atrial septal defect in a 5-year-old girl using total-body hypothermia. (frontiersin.org)
- This study is a prospective, multi-centre, randomized,controlled trial to compare the efficacy of long-term mild hypothermia with normothermic intensive management in patients with poor-gr. (bioportfolio.com)
- The efficacy of hypothermia in acute ischemic stroke (AIS) and traumatic brain injury (TBI), however, is not well studied. (frontiersin.org)
- The efficacy of this therapeutic approach has a relatively restricted time-window [ 16 ]. (hindawi.com)
- Perhaps the oldest hypothesis is that a reduction in metabolic demand should increase tolerance to a decrease in oxygen and nutrient supply and therefore that the protective efficacy of hypothermia and of some anesthetics is related to reductions in cerebral metabolic rate. (asahq.org)
- Intravascular Cooling for the Treatment of Stroke-Longer window (ICTuS-L), Nordic Cooling Stroke Study (NOCSS), Controlled Hypothermia in Large Infarction (CHILI), and the Combined Cytoprotection rt-PA Stroke Trial investigating the efficacy of caffeine, ethanol, and cooling via a femoral catheter for 24 hours with or without rt-PA. (americorpshealth.biz)
- BACKGROUND: The highly selective α2 -adrenoreceptor agonist, dexmedetomidine, exerts neuroprotective, analgesic, anti-inflammatory and sympatholytic properties that may be beneficial for perinatal asphyxia. (edu.au)
- If proven efficacious and safe, allopurinol could become part of a neuroprotective pharmacological treatment strategy in addition to therapeutic hypothermia in children with perinatal asphyxia. (biomedcentral.com)
- Temperature management and therapeutic hypothermia is discussed in this review. (touchneurology.com)
- However, one must be aware that controversy exists regarding the potential benefit of therapeutic hypothermia for cardiac arrest, especially given the results of the landmark targeted temperature management (TTM) trial. (touchneurology.com)
- Meta-analyses of nonrandomized studies have provided conflicting data on therapeutic hypothermia, or targeted temperature management (TTM), at 33°C in patients successfully resuscitated after nonshockable cardiac arrest. (biomedcentral.com)
- It is a non-invasive precision temperature management system that is used to induce hypothermia in comatose patients that have suffered from Sudden Cardiac Arrest (SCA) and patients at risk for ischemic brain damage. (wikipedia.org)
- Can Mild Hypothermia Treatment Improve Neuron Survival After Traumatic Brain Injury? (liebertpub.com)
- Therapeutic hypothermia after cardiac arrest har shown to improve the rate of survival in a significant way. (clinicaltrials.gov)
- Therapeutic hypothermia, a treatment in which the patient's body temperature is lowered and maintained several degrees below normal for a period of time, has been shown to mitigate these harmful effects and improve survival in adults. (bio-medicine.org)
- In this new study, we aim to show that therapeutic hypothermia can give these children a better chance at survival and long-term quality of life. (bio-medicine.org)
- Cooling the patient for some time is known to mitigate this harmful effect and improve survival, under a procedure known as therapeutic hypothermia. (rxpgnews.com)
- Conclusion: Hypothermia improves survival and neu-Intervention: Therapeutic hypothermia. (slideshare.net)
- A number of recent studies have concluded that the use of induced hypothermia can improve survival and limit the level of neurological impairment following cardiac arrest. (ispub.com)
- Several studies have shown that the use of induced hypothermia can improve rates of survival and level of neurological function following a cardiac arrest 5, 6, 7 . (ispub.com)
- In December 2005, to improve survival rates, the American Heart Association (AHA) published resuscitation recommendations for using mild hypothermia. (myamericannurse.com)
- In a rat model of cardiac arrest, better postresuscitation myocardial function, neurological deficit scores, and longer duration of survival were observed by the pharmacologically induced hypothermia with WIN55, 212-2. (curehunter.com)
- Patients: twenty ventilated and sedated adults patients with septic shock Intervention: Mild therapeutic hypothermia between 32 and 34°C during 36 consecutive hours using an external water cooling blanket. (bioportfolio.com)
- IRI typically arises in patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), in whom the most effective therapeutic intervention for reducing acute myocardial ischemic injury and limiting the size of myocardial infarction (MI) is timely and effective myocardial reperfusion using either thrombolytic therapy or primary percutaneous coronary intervention (PPCI). (jci.org)
- MEDLINE/PubMed, CENTRAL, Stroke Center, and ClinicalTrials.gov were systematically searched for hypothermia intervention induced by external or endovascular cooling for acute stroke. (hindawi.com)
- Induced hypothermia is increasingly applied as a therapeutic intervention in ICUs. (biomedcentral.com)
- Further trials to determine the appropriate techniques of cooling, including refinement of patient selection, duration of cooling and method of providing therapeutic hypothermia, will refine our understanding of this intervention. (nih.gov)
- Although it still remains controversial who, how, when, and for how long to cool, with only six patients requiring treatment to save one additional life, it is clear that therapeutic hypothermia is the single most effective intervention in brain resuscitation available today. (oalib.com)
- Who benefits most from mild therapeutic hypothermia in coronary intervention era? (biomedcentral.com)
- Without evidence of benefit, an intervention should not be presumed to be beneficial or safe. (roguemedic.com)
- Therapeutic hypothermia is recommended for comatose adults after witnessed out-of-hospital cardiac arrest, but data about this intervention in children are limited. (extrememember.com)
- This effect was further amplified when the slices were incubated at 32°C after trauma.When used in combination, the dose-dependent neuroprotective effect of propofol is additive to the neuroprotective effect of hypothermia in an in vitro model of traumatic brain injury.Traumatic brain injury (TBI) is a common consequence of traffic-related accidents and incidents at work and at home. (oalib.com)
- In addition to inhibiting neuronal cell death, therapeutic treatments targeting inflammasome activation may also provide beneficial effects by reducing the potentially detrimental consequences of activated microglia and infiltrating CD11b+ leukocytes following penetrating traumatic brain injury. (biomedcentral.com)
- Therapeutic hypothermia is beneficial in children with moderate EAI. (bioportfolio.com)
- In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries. (bioportfolio.com)
- Induction of moderate hypothermia (28°C to 32°C) before cardiac arrest has been used successfully since the 1950s to protect the brain against the global ischemia that occurs during some open-heart surgeries. (ahajournals.org)
- Controlled Hypothermia has become the standard of care for neonates with moderate to severe HIE. (clinicaltrials.gov)
- Controlled hypothermia (CH) has been accepted as a neuroprotective therapeutic modality for neonates with moderate to severe HIE because of its role in attenuating secondary brain injury. (clinicaltrials.gov)
- Endothelial adaptation to mild-moderate hypothermia down-regulates anabolic processes and increases the reducing capacity of cells to enhance their resistance to oxidation and injury associated with 0°C storage and rewarming. (biomedcentral.com)
- Interestingly, the cells of non-hibernating mammals adapt to mild-moderate hypothermia in tissue culture [ 16 - 19 ] in what is likely a conserved response to cold and several mechanisms of cold-induced changes in gene expression have been identified. (biomedcentral.com)
- The effect of moderate craniocerebral hypothermia (CCH) (32°C) on total proteinase activity (TPA), the activity of non-trypsin-like proteinases (NTLP) and their inhibitors (a-1-proteinase inhibitor (a-1-PI) and a-2-macroglobulin (a-2-MG) in the tissue samples of CNS (brain cortex, hypothalamus, cerebellum), peripheral organs (heart, lungs, liver, kidneys) and serum blood in rats was studied. (org.ua)
Effect of hypothermia1
- The combined effect of hypothermia and cannabidiol on excitotoxicity, inflammation and oxidative stress, and on cell damage, was greater than either hypothermia or cannabidiol alone. (frontiersin.org)
Application of therapeutic hypothermia3
Effectiveness of therapeutic hypothermia1
- OBJECTIVES: We performed a systematic review and meta-analysis to assess the effectiveness of therapeutic hypothermia in patients after cardiac arrest. (hipotermiaterapeutyczna.pl)
- Jehle D, Meyer M, Gemme S. Beneficial response to mild therapeutic hypothermia for comatose survivors of near-hanging. (umassmed.edu)
- And although the matter remains controversial, the recommendation still stands for therapeutic hypothermia to be offered for all comatose survivors of cardiac arrest whatever the arrest rhythm. (clinicaltrials.gov)
- Therefore, treatment of comatose survivors of out-of-hospital cardiac arrest using mild therapeutic hypothermia has now been widely adopted around the globe. (oalib.com)
- Therapeutic hypothermia is more beneficial in comatose survivors of cardiac arrest with CPA-ROSC greater than 15 minutes. (biomedcentral.com)
- 2002). „Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. (hipotermiaterapeutyczna.pl)
Return of spontaneous circulation5
- 4 Since then, induction of hypothermia after return of spontaneous circulation (ROSC) has been associated with improved functional recovery and reduced cerebral histological deficits in various animal models of cardiac arrest. (ahajournals.org)
- The aim of the present study was to investigate the impact of the time interval from collapse to return of spontaneous circulation (CPA-ROSC) in cardiac arrest patients and the types of patients who will benefit from therapeutic hypothermia. (biomedcentral.com)
- The role of hypothermia in post-cardiac arrest patients with return of spontaneous circulation: a systematic review. (prelekara.sk)
- It seems that prehospital cooling (induced therapeutic hypothermia) after return of spontaneous circulation is losing favor in EMS. (limmercreative.com)
- In 2005, the American Heart Association implemented recommendations and guidelines for mild hypothermia in post-resuscitation support after cardiac arrest with return of spontaneous circulation. (wikipedia.org)
- METHODS: Following cerebral hypoxia-ischaemia, dexmedetomidine was administered to nine newborn piglets in a de-escalation dose study in combination with hypothermia (whole body cooling to 33.5°C). Dexmedetomidine was administered with a loading dose of 1 μg/kg and maintenance infusion at doses from 10 to 0.6 μg/kg/h. (edu.au)
- Reduced clearance was related to cumulative effects of both hypothermia and exposure to hypoxia. (edu.au)
- In significantly unstable patients, providers may consider using extracorporeal membrane oxygenation (ECMO) as salvage treatment for refractory hypoxia or hypothermia. (statpearls.com)
- After hypoxia-ischaemia (HI), 20 large White male piglets were randomized to: (i) hypothermia + fentanyl with cooling to 33.5°C from 2 to 26 h, or (ii) hypothermia + dexmedetomidine (a loading dose of 2 µg/kg at 10 min followed by 0.028 µg/kg/h for 48 h). (bvsalud.org)
- Alva N., Palomeque J., Carbonell T. Deep hypothermia protects against acute hypoxia in vivo in rats: a mechanism related to the attenuation of oxidative stress. (org.ua)
- In animal models, hypothermia also reduces infarct volume, decreases cerebral metabolism, reduces excitotoxicity due to synaptic glutamate overflow, and stabilizes the blood-brain barrier and neuronal membranes, while decreasing cerebral edema in animal models of acute stroke [ 12 - 15 ]. (hindawi.com)
- Rivera-Lara L, Zhang J, Muehlschlegel S. Therapeutic hypothermia for acute neurological injuries. (umassmed.edu)
- In regards to blood pressure targets, while permissive hypertension is often recognized as a beneficial strategy in acute stroke, blood pressure reduction is essential for secondary stroke prevention. (touchneurology.com)
- 1) We make no recommendation as to whether neuromuscular blockade is beneficial or harmful when used in patients with acute brain injury and raised intracranial pressure. (bvsalud.org)
- The results of a recent trial (Cooling for Acute Ischemic Brain Damage [COOL-AID])105 suggest that the combination of intra-arterial thrombolysis plus mild hypothermia via external cooling is safe, although mean time to achieve the target temperature was 3.5 ± 1.5 hours. (americorpshealth.biz)
- 1 Shortly thereafter, the Committee on Fetus and Newborn of the American Academy of Pediatrics published a commentary supporting the recommendation of the workshop that the widespread implementation of hypothermia outside the limits of controlled trials was premature. (aappublications.org)
- After publication of the seminal trials of therapeutic hypothermia after cardiac arrest, 2,3 this approach was recommended in international guidelines, 4 despite arguments by some investigators that the evidence was weak, owing to the risk of bias and small samples. (roguemedic.com)
- In this review, we will try to reconcile new and old data, explain discordant results, and discuss future trials of therapeutic hypothermia and other aspects of the management of cardiac arrest survivors. (healthmanagement.org)
- Although many preclinical treatment studies have been encouraging, there remains a lack of successful translation to the clinic and no therapeutic treatments have shown benefit in phase 3 multicenter trials. (braincirculation.org)
- Based on these results, additional controlled trials are now underway to test the therapeutic impact of hypothermia combined with thrombolysis. (americorpshealth.biz)
- METHODS: Relevant studies were identified after two consensus meetings of the SSAI Task Force on Therapeutic Hypothermia (SSAITFTH) and via literature search of the Cochrane Central Register of Controlled Trials and Medline. (lsh.is)
Treated with induced hypothermia1
- These notes were reviewed and the following was recorded: age, gender, location of arrest (in or out of hospital), initial heart rhythm, extent of CPR required, whether the patient was treated with induced hypothermia and how soon following arrest cooling commenced. (ispub.com)
- Intentional systemic hypothermia or therapeutic hypothermia was first documented in modern times in 1943. (jems.com)
- Thereby, hypothermia may mitigate harm caused by an 'overshoot' of a systemic inflammatory response. (biomedcentral.com)
- and myocardial preservation with cold cardioplegia during a single period of cross clamping, topical cold, and systemic hypothermia. (curehunter.com)
- Background: Hypothermia has been discussed as playing a role in improving the early phase of systemic inflammation. (uni-frankfurt.de)
- We therefore investigated the kinetics of local and systemic inflammation in the late posttraumatic phase after induction of hypothermia in an established porcine long-term model of combined trauma. (uni-frankfurt.de)
- Induction of hypothermia resulted in a significantly prolonged elevation of both systemic and local HMGB1 levels at 48 h compared to the NT-T group. (uni-frankfurt.de)
- Hypothermia was associated with a lower cardiac index, higher systemic vascular resistance, and hyperglycemia. (hipotermiaterapeutyczna.pl)
- In this respect, myocardial reperfusion injury remains a neglected therapeutic target for cardioprotection in PPCI patients. (jci.org)
- At the ultimate tolerable heart rate during hypothermia, S′ decreased, probably as a consequence of myocardial hypoperfusion due to sustained ventricular contraction throughout a very short diastole. (springeropen.com)
Impact of hypothermia1
- However, information on the impact of hypothermia on the local inflammatory response is sparse. (uni-frankfurt.de)
- Hypothermia (therapeutic): One systematic review updated. (neurocirurgiabr.com)
- An emerging treatment, therapeutic hypothermia (TH), is a promising neuroprotective therapy in stroke management. (hindawi.com)
- Therapeutic hypothermia is likely a beneficial treatment following traumatic brain injuries in adults but cannot be recommended in children," the authors write. (empr.com)
- Study questions hypothermia treatment for card. (bio-medicine.org)
- The main objective of the study was to investigate the optimal temperature for hypothermia treatment of patients in cardiac arrest, and to investigate the neurological function and quality of life of survivors after discharge from hospital. (bio-medicine.org)
- General principles of hypothermia treatment 6. (ebscohost.com)
- Therapeutic hypothermia has since been widely adopted by most authorities as part of the comprehensive treatment bundle for post cardiac arrest syndrome. (clinicaltrials.gov)
- Therapeutic hypothermia has also been discussed as being a beneficial treatment adjuvant. (statpearls.com)
- At present, induced hypothermia has yet to be recognized or approved as a potential treatment having therapeutic value for traumatic SCI in humans. (curehunter.com)
- Currently, the only known treatment for HIE is called hypothermia therapy (also known as body cooling , brain cooling , therapeutic hypothermia , or hypothermia treatment ). (abclawcenters.com)
- Research shows that when hypothermia treatment is promptly given after an oxygen-depriving insult, the incidence of death and cerebral palsy is significantly reduced. (abclawcenters.com)
- Realizing hypothermia's full therapeutic potential will therefore require meticulous attention to the prevention and/or early treatment of side effects, as well as a basic knowledge and understanding of the underlying physiological and pathophysiological mechanisms. (hollos.net)
- Hypothermia + dexmedetomidine treatment was neurotoxic following HI in our piglet NE model, suggesting that caution is vital if dexmedetomidine is combined with cooling following NE. (bvsalud.org)
- Our aim was to test whether immediate treatment with cannabidiol and hypothermia act through complementary brain pathways in hypoxic-ischemic newborn piglets. (frontiersin.org)
- In some cases, therapeutic hypothermia can prevent or minimize permanent brain damage, although it must be given within just hours of the baby's birth/oxygen-depriving injury (see "Treatment for HIE" for more information). (hiehelpcenter.org)
Provided a neuroprotective effect1
- Linares and Mayer, 2009 ), which raised the possibility that hypothermia provided a neuroprotective effect in the case of anoxic brain injury ( Linares and Mayer, 2009 ). (frontiersin.org)
- Enhanced beneficial effects of mild hypothermia by phenothiazine drugs in stroke therapy. (annals.org)
- Since then, hypothermia has been used for patients with head injury, cardiac arrest and stroke as well as during various surgical procedures, hoping to reap protective effects for the heart and brain. (jems.com)
- A significant focus of stroke research is the development of therapeutic strategies that prevent neuronal death and improve recovery, but, unfortunately, few therapeutic strategies have successfully moved from basic science laboratories to the clinic. (ajnr.org)
- Motor and sensory effects of ipsilesional upper extremity hypothermia and contralesional sensory training for chronic stroke patients. (annals.org)
- Hypothermia reduced heart rate from 87 ± 10 (SD) to 76 ± 11 beats/min without any changes in LV stroke volume, end-diastolic volume, EF, strain values, or PRSW. (springeropen.com)
- Pacing did not affect S′ or PRSW at physiological heart rates, but stroke volume, end-diastolic volume, and strain were reduced as a consequence of reduced diastolic filling and much more accentuated during hypothermia. (springeropen.com)
- The therapy has been used successfully in adult cardiac arrest patients, and has been shown beneficial for newborns who have received insufficient oxygen at birth. (bio-medicine.org)
- Our aim was therefore to report on a three-year experience of therapeutic hypothermia among asphyxiated newborns. (scielo.br)
- Hypothermia as therapy for asphyxiated newborns was shown to be safe. (scielo.br)
- The effect of ambient temperature on cold saline during simulated infusion to induce therapeutic hypothermia. (umassmed.edu)
- Objectives: to evaluate the feasibility, the safety and the effects on physiological parameters of mild therapeutic hypothermia during septic shock. (bioportfolio.com)
- Hypothermia exerts complex effects on human physiology. (frontiersin.org)
- Although the underlying mechanisms have never been completely understood, it is already well accepted that hypothermia decreases brain edema and mitigates the effects of brain ischemia/reperfusion, which are temperature dependent. (hindawi.com)
- Therapeutic hypothermia cooling the body and brain down to 33C is the method used worldwide to treat cardiac arrest, even though a lower body temperature may raise the risk of side-effects. (bio-medicine.org)
- Neonates exhibit varying degrees of multiorgan dysfunction after a hypoxic-ischemic insult, although the added beneficial and potential adverse effects that CH has in these babies have not been completely delineated or understood. (clinicaltrials.gov)
- One of the underlying mechanisms of the beneficial effects of hypothermia is proposed to be reduction of the inflammatory response. (biomedcentral.com)
- Some adverse effects of hypothermia included an increase sinus bradycardia and a significant increase in thrombocytopenia. (nih.gov)
- Albeit therapeutic hypothermia had been used as effective measure to ameliorate cerebral ischemia-reperfusion injury during surgery for decades, it was not yet introduced into regular post-arrest care until 2003 due to significant side effects of profound hypothermia. (oalib.com)
- When body temperature is kept around 33°C, the beneficial effects of hypothermia clearly outweigh its adverse effects. (oalib.com)
- 5. E F, B R, SN S. Beneficial effects of hypothermia after cardiac arrest. (prelekara.sk)
- New data are available on the adverse effects of therapeutic hypothermia, notably infectious complications. (biomedcentral.com)
- This review focuses on the practical aspects of cooling and physiological changes induced by hypothermia, as well as the potential side effects that may develop. (hollos.net)
- 16 ] This finding suggests that hypothermia and anesthetics have different effects on the relation between cerebral metabolism and the rate of ischemic membrane failure. (asahq.org)
- Alva N., Palomeque J., Carbonell T. Oxidative stress and antioxidant activity in hypothermia and rewarming: can RONS modulate the beneficial effects of therapeutic hypothermia? (org.ua)
- The present study demonstrated that cannabidiol and hypothermia act complementarily and show additive effects on the main factors leading to hypoxic-ischemic brain damage if applied shortly after the insult. (frontiersin.org)
- This article therefore summarizes several factors that are important in enhancing the beneficial effects of therapeutic hypothermia in TBI. (braincirculation.org)
- 28°C) hypothermia, therapeutic hypothermia is well tolerated with few side effects, and hemodynamic stability seems to be well preserved. (springeropen.com)
- However, therapeutic hypothermia affects cardiac performance, and the dominating effects on the normal heart may differ substantially from the effects on hearts exposed to some kind of injury. (springeropen.com)
- Conclusion: A prolonged inflammatory response might reduce the well-described protective effects on organ and immune function observed in the early phase after hypothermia induction. (uni-frankfurt.de)
- Beneficial effects of rapamycin in a Drosophila model for hereditary spastic paraplegia. (sdbonline.org)
Resuscitation from cardiac arrest1
- 9-16 At the time of publication of the Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care , the evidence was insufficient to recommend use of therapeutic hypothermia after resuscitation from cardiac arrest. (ahajournals.org)
- Study participants will be randomly selected to either have their body cooled through therapeutic hypothermia or maintained at normal body temperature. (bio-medicine.org)
- Those receiving hypothermia will have their body temperature reduced to between 89.6 and 93.2 Fahrenheit (F) for two days, then slowly increased to a normal body temperature and maintained for another three days. (bio-medicine.org)
- Patients with a body temperature of 33°C did not differ from patients with a body temperature of 36°C, suggesting induced hypothermia does not affect immune response in patients with cardiac arrest. (biomedcentral.com)
- Therapeutic hypothermia, which lowers the patient's body temperature to levels between 32-34 °C (90-93 °F), is used to help reduce the risk of the ischemic injury to the brain following a period of insufficient blood flow. (wikipedia.org)
- Mild hypothermia appears to reduce the number of adverse reactions that occur after reperfusion. (jems.com)
- CONCLUSIONS: Dexmedetomidine clearance was reduced almost tenfold compared with adult values in the newborn piglet following hypoxic-ischaemic brain injury and subsequent therapeutic hypothermia. (edu.au)