Thalassemia. Medical search

A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.

A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.

A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.

An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations.

Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.

A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure.

Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.

An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)

A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.

Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.

An adult hemoglobin component normally present in hemolysates from human erythrocytes in concentrations of about 3%. The hemoglobin is composed of two alpha chains and two delta chains. The percentage of HbA2 varies in some hematologic disorders, but is about double in beta-thalassemia.

Members of the alpha-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 16. They include zeta-globin and alpha-globin. There are also pseudogenes of zeta (theta-zeta) and alpha (theta-alpha) in the cluster. Adult HEMOGLOBIN is comprised of 2 alpha-globin chains and 2 beta-globin chains.

The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.

The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)

Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.

Pyridine derivatives with one or more keto groups on the ring.

Members of the beta-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 11. They include epsilon-globin, gamma-globin, delta-globin and beta-globin. There is also a pseudogene of beta (theta-beta) in the gene cluster. Adult HEMOGLOBIN is comprised of two ALPHA-GLOBIN chains and two beta-globin chains.

A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.

An abnormal hemoglobin composed of four beta chains. It is caused by the reduced synthesis of the alpha chain. This abnormality results in ALPHA-THALASSEMIA.

A group of abnormal hemoglobins with similar electrophoretic characteristics. They have faster electrophoretic mobility and different amino acid substitutions in either the alpha or beta chains than normal adult hemoglobin. Some of the variants produce hematologic abnormalities, others result in no clinical disorders.

A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.

An individual in which both alleles at a given locus are identical.

The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.

Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.

Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.

The condition of being heterozygous for hemoglobin S.

An individual having different alleles at one or more loci regarding a specific character.

ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC).

The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.

Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.

Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.

Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes.

A hereditary disorder characterized by reduced or absent DELTA-GLOBIN thus effecting the level of HEMOGLOBIN A2, a minor component of adult hemoglobin monitored in the diagnosis of BETA-THALASSEMIA.

Measurement of hemoglobin concentration in blood.

The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.

Surgical procedure involving either partial or entire removal of the spleen.

An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.

Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)

RED BLOOD CELL sensitivity to change in OSMOTIC PRESSURE. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst.

Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.

Identification of genetic carriers for a given trait.

A commonly occurring abnormal hemoglobin in which lysine replaces a glutamic acid residue at the sixth position of the beta chains. It results in reduced plasticity of erythrocytes.

The formation and development of blood cells outside the BONE MARROW, as in the SPLEEN; LIVER; or LYMPH NODES.

The great peninsula of southwest Asia comprising most of the present countries of the Middle East. It has been known since the first millennium B.C. In early times it was divided into Arabia Petraea, the northwest part, the only part ever conquered, becoming a Roman province; Arabia Deserta, the northern part between Syria and Mesopotamia; and Arabia Felix, the main part of the peninsula but by some geographers restricted to modern Yemen. (From Webster's New Geographical Dictionary, 1988, p63)

A member of the beta-globin family. In humans, delta-globin is encoded in the beta-globin gene cluster located on CHROMOSOME 11. Two delta-globin chains along with two alpha-globin chains form HEMOGLOBIN A2 which makes up about 3% of the HEMOGLOBIN in adults.

The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.

Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.

The research and development of ELECTRICAL EQUIPMENT AND SUPPLIES for such medical applications as diagnosis, therapy, research, anesthesia control, cardiac control, and surgery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

A disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. There may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.

One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.

A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

The collective name for the islands of the Pacific Ocean northeast of Australia, including NEW CALEDONIA; VANUATU; New Hebrides, Solomon Islands, Admiralty Islands, Bismarck Archipelago, FIJI, etc. Melanesia (from the Greek melas, black + nesos, island) is so called from the black color of the natives who are generally considered to be descended originally from the Negroid Papuans and the Polynesians or Malays. (From Webster's New Geographical Dictionary, 1988, p748 & Room, Brewer's Dictionary of Names, 1992, p344)

Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)

Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.

A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed)

Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.

Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.

Electrophoresis applied to BLOOD PROTEINS.

The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.

Actual loss of portion of a chromosome.

A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.

Abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells. They are seen in thalassemias, enzymopathies, hemoglobinopathies, and after splenectomy.

Members of the beta-globin family. In humans, two non-allelic types of gamma-globin - A gamma and G gamma are encoded in the beta-globin gene cluster on CHROMOSOME 11. Two gamma-globin chains combine with two ZETA-GLOBIN chains to form the embryonic hemoglobin Portland. Fetal HEMOGLOBIN F is formed from two gamma-globin chains combined with two ALPHA-GLOBIN chains.

The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.

An island republic in the eastern Mediterranean Sea. Its capital is Nicosia. It was colonized by the Phoenicians and ancient Greeks and ruled successively by the Assyrian, Persian, Ptolemaic, Roman, and Byzantine Empires. It was under various countries from the 12th to the 20th century but became independent in 1960. The name comes from the Greek Kupros, probably representing the Sumerian kabar or gabar, copper, famous in historic times for its copper mines. The cypress tree is also named after the island. (From Webster's New Geographical Dictionary, 1988, p308 & Room, Brewer's Dictionary of Names, 1992, p134)

The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.

The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.

Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.

A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).

Iron or iron compounds used in foods or as food. Dietary iron is important in oxygen transport and the synthesis of the iron-porphyrin proteins hemoglobin, myoglobin, cytochromes, and cytochrome oxidase. Insufficient amounts of dietary iron can lead to iron-deficiency anemia.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

A benign familial disorder, transmitted as an autosomal dominant trait. It is characterized by low-grade chronic hyperbilirubinemia with considerable daily fluctuations of the bilirubin level.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and deltabeta-thalassemia affects beta- but not gamma-globin gene expression. (1/992)

The analysis of a number of cases of beta-globin thalassemia and hereditary persistence of fetal hemoglobin (HPFH) due to large deletions in the beta-globin locus has led to the identification of several DNA elements that have been implicated in the switch from human fetal gamma- to adult beta-globin gene expression. We have tested this hypothesis for an element that covers the minimal distance between the thalassemia and HPFH deletions and is thought to be responsible for the difference between a deletion HPFH and deltabeta-thalassemia, located 5' of the delta-globin gene. This element has been deleted from a yeast artificial chromosome (YAC) containing the complete human beta-globin locus. Analysis of this modified YAC in transgenic mice shows that early embryonic expression is unaffected, but in the fetal liver it is subject to position effects. In addition, the efficiency of transcription of the beta-globin gene is decreased, but the developmental silencing of the gamma-globin genes is unaffected by the deletion. These results show that the deleted element is involved in the activation of the beta-globin gene perhaps through the loss of a structural function required for gene activation by long-range interactions. (+info)

A new alkali-resistant hemoglobin alpha2J Oxford gammaF2 in a Sicilian baby girl with homozygous beta0 thalassemia. (2/992)

A 10-mo-old baby girl with homozygous beta0 thalassemia and alphaJOxford, presenting the clinical picture of homozygous beta thalassemia is described. Hemoglobin electrophoresis showed three bands: the first two with the mobilities of hemoglobin Hb A2 (1%) and Hb F (69%), respectively, the third migrating a little faster than Hb A (30%). About 30% of her alpha chains were J Oxford which, bound to her gamma chains, produced a new alkali-resistant hemoglobin, alpha2 J Oxford gamma F2, which has not been described previously. Hemoglobin synthesis in vitro showed the absence of beta chain synthesis and an alpha/non-alpha ratio of 2. The patient's father was heterozygous for both the Hb J Oxford and beta0 thalassemia genes, the mother a carrier of beta0 thalassemia; four other relatives were carriers of Hb J Oxford, and one was a carrier of beta thalassemia. (+info)

'Common' uncommon anemias. (3/992)

Of the uncommon anemias, "common" types include the anemia of renal disease, thalassemia, myelodysplastic syndrome and the anemia of chronic disease. These conditions may be suggested by the clinical presentation, laboratory test values and peripheral blood smear, or by failure of the anemia to respond to iron supplements or nutrient replacement. The principal cause of the anemia of renal disease is a decreased production of red blood cells related to a relative deficiency of erythropoietin. When treatment is required, erythropoietin is administered, often with iron supplementation. In the anemia of chronic disease, impaired iron transport decreases red blood cell production. Treatment is predominantly directed at the underlying condition. Since iron stores are usually normal, iron administration is not beneficial. Thalassemia minor results from a congenital abnormality of hemoglobin synthesis. The disorder may masquerade as mild iron deficiency anemia, but iron therapy and transfusions are often not indicated. In the myelodysplastic syndrome, blood cell components fail to mature, and the condition may progress to acute nonlymphocytic leukemia. The rate of progression depends on the subtype of myelodysplasia, but the leukemia is usually resistant to therapy. (+info)

Hormonal changes in thalassaemia major. (4/992)

Patients with severe thalassaemia major suffer endocrine and other abnormalities before their eventual death from iron overload due to repeated blood transfusions. The endocrine status of 31 thalassaemic patients aged 2-5 to 23 years was investigated. Exact data were available on the rate and duration of blood transfusion in all of them and in many the liver iron concentration was also known. Although the patients were euthyroid, the mean serum thyroxine level was significantly lower, and the mean thyrotrophic hormone level significantly higher, compared with the values found in normal children. Forty oral glucose tolerance tests with simultaneous insulin levels were performed in 19 children, of whom 5 developed symptomatic diabetes and one had impaired tolerance. Previous tests on all 6 patients were available and some showed raised insulin levels possibly due to insulin resistance. 2 patients had clinical hypoparathyroidism and are described. The parathyroid hormone levels determined by radioimmunoassay in 25 patients were below the mean for the age group in all and outside the reference range in 16. Nonfasting plasma calcium levels were not reduced. Puberty was delayed in some patients. Concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) measured in urine from 7 girls and 5 boys showed considerable variation. In the boys there was an overall tendency for FSH and LH excretion to be low with regard to age, but with respect to puberty rating FSH exretions were normal or low and LH normal or raised. The girls showed a tendency for LH but not FSH excretion to be raised in relation to puberty rating. The severity of the endocrine changes was related to the degree of iron loading and is discussed in relation to previous work in which the iron loading has rarely been accurately indicated nor parathyroid status assessed. (+info)

Birth of healthy children after preimplantation diagnosis of thalassemias. (5/992)

BACKGROUND: Preimplantation genetic diagnosis (PGD) allows couples at risk of having children with thalassemia to ensure the healthy outcome of their pregnancy. METHODS: Seventeen PGD clinical cycles were initiated for Cypriot couples at risk of having children with different thalassemia mutations, including IVSI-110, IVSI-6, and IVS II-745. Unaffected embryos for transfer were selected by testing oocytes, using first and second polar body (PB) removal and nested polymerase chain reaction analysis followed by restriction digestion. RESULTS: Unaffected embryos were selected in 16 of 17 PGD cycles. Of 166 oocytes studied from these cycles, 110 were analyzed by sequential analysis of both the first and the second PB, resulting in preselection and transfer of 45 unaffected embryos. This resulted in seven pregnancies and in the birth of five healthy thalassemia-free children. The embryos predicted to have inherited the affected allele were not transferred. Analysis of these embryos confirmed the PB diagnosis. CONCLUSIONS: Sequential first and second PB testing of oocytes is reliable for PGD of thalassemia and is a feasible alternative to prenatal diagnosis in high-risk populations. (+info)

Further evidence of a quantitative deficiency of chain-specific globin mRNA in the thalassemia syndromes. (6/992)

Formamide gel electrophoresis separates the mRNA fraction from reticulocyte polyribosomes of adult humans into two major RNA species with migratory rates identical to those of the alpha- and beta-globin mRNAs of the rabbit. That these two RNAs of human origin are the globin mRNAs is further supported by the deficiency of the presumed beta mRNA in reticulocyte polyribosomes of fetuses and premature infants, whose cells make gamma chains in preference to beta chains. The globin mRNAs of reticulocyte polyribosomes from patients with hematological disorders were estimated by scanning the stained formamide gels. In contrast to individuals with either hemolytic anemia without hemoglobinopathy or sickle cell anemia who had beta mRNA to alpha mRNA ratios of approximately one, a patient with Hb S-beta-thalassemia had a ratio of beta mRNA to alpha mRNA of 0.75 while two subjects with homozygous beta-thalassemia had severe deficiencies of beta mRNA. Conversely, a patient with alpha-thalassemia (Hb H disease) had a ratio of beta mRNA to alpha mRNA on reticulocyte polyribosomes of 6. These data provide further evidence of a quantitative deficiency of chain-specific globin mRNA in patients with the thalassemia syndromes. (+info)

Coexistence of two functioning T-cell repertoires in healthy ex-thalassemics bearing a persistent mixed chimerism years after bone marrow transplantation. (7/992)

Bone marrow transplantation (BMT) from an HLA-identical donor is an established therapy to cure homozygous beta-thalassemia. Approximately 10% of thalassemic patients developed a persistent mixed chimerism (PMC) after BMT characterized by stable coexistence of host and donor cells in all hematopoietic compartments. Interestingly, in the erythrocytic lineage, close to normal levels of hemoglobin can be observed in the absence of complete donor engraftment. In the lymphocytic lineage, the striking feature is the coexistence of immune cells. This implies a state of tolerance or anergy, raising the issue of immunocompetence of the host. To understand the state of the T cells in PMC, repertoire analysis and functional studies were performed on cells from 3 ex-thalassemics. Repertoire analysis showed a profound skewing. This was due to an expansion of some T cells and not to a collapse of the repertoire, because phytohemagglutinin stimulation showed the presence of a complex repertoire. The immunocompetence of the chimeric immune systems was further established by showing responses to alloantigens and recall antigens in vitro. Both host and donor lymphocytes were observed in the cultures. These data suggest that the expanded T cells play a role in specific tolerance while allowing a normal immune status in these patients. (+info)

Relative numbers of human globin genes assayed with purified alpha and beta complementary human DNA. (8/992)

Purified alpha and beta globin complementary DNAs (cDNAs) have been separated from total radioactively labeled human globin cDNA using mRNA purified from liver of a hydrops fetalis (alpha thalassemia). The beta cDNA hybridizes to the hydrops fetalis mRNA while the alpha cDNA remains single-stranded. the purified alpha and beta cDNAs were assayed for their purity by their hybridization to mRNA prepared from reticulocytes of nonthalassemia, alpha thalassemia, and beta thalassemia subjects. The results indicate that the separated cDNAs are selective in hybridization to alpha or beta globin mRNAs, respectively. The previously reported deficiency of globin mRNA in thalassemia cells has been confirmed with these purified cDNAs. The purified alpha and beta cDNAs were hybridized to cellular DNA to non-thalassemia, beta+ thalassemia, and hydrops fetalis (alpha thalassemia) DNA. The alpha cDNA hybridized to hydrops fetalis liver DNA to a much lower extent that beta cDNA, confirming the previously reported deletion of alpha globin genes in hydrops fetalis. By contrast, both the alpha and beta DNA probes hybridized to the same extent to spleen DNA from non-thalassemia and from beta+ thalassemia patients. Between two and five globin genes in non-thalassemia and beta+ thalassemia DNA hybridize to beta cDNA and one to five to alpha cDNA. These studies indicate that in beta+ thalassemia, there is no detectable deletion in beta globin genes. The genetic defect in beta+ thalassemia appears to be due to either repression of transcription of beta globin genes or abnormal processing of beta globin mRNA. (+info)

Total loss called, thalassemia major or beta-0-thalassemia, is due to mutation in both alleles, and this results in failure to ... Reduced HBB function called thalassemia minor or beta+ thalassemia is due to mutation in one of the alleles. It is less severe ... "Beta thalassemia". Genetics Home Reference. U.S. National Library of Medicine. 11 November 2014. Retrieved 18 November 2014. ... Even though the unstable protein itself has mild effect, inherited with HbS and thalassemia traits, it turns into a life- ...

https://en.wikipedia.org/wiki/HBB

In β thalassemia major the beta hemoglobin chain is completely absent, rendering an increase in fetal hemoglobin (HbF). Alam, ... The underlying cause can be attributed to various anemias, most often; beta thalassemia major, a form of microcytic anemia. ... Galanello, Renzo; Origa, Raffaella (2010-05-21). "Beta-thalassemia". Orphanet Journal of Rare Diseases. 5: 11. doi:10.1186/1750 ...

https://en.wikipedia.org/wiki/Anisopoikilocytosis

"alpha thalassemia". Genetics Home Reference. NIH U.S. National Library of Medicine. 14 November 2017. Whetstine JR. "Histone ... In a class of alpha-thalassemia, a type of blood disorder that has reduced level of hemoglobin leading to insufficient oxygen ...

https://en.wikipedia.org/wiki/Antisense_RNA

Hemoglobin variants Hemoglobinopathy Thalassemia What is Thalassemia? Hemoglobin H Disease and its Variants Hemoglobinopathiesm ... It is the most common nondeletional alpha-thalassemia mutation associated with hemoglobin H disease. The quantity of hemoglobin ...

https://en.wikipedia.org/wiki/Hemoglobin_Constant_Spring

"Beta thalassemia". Genetics Home Reference. U.S. National Library of Medicine, NIH. March 13, 2011. Retrieved 21 March 2011. ... Hemoglobinopathies and Thalassemias "Sickle Cell Trait and Other Hemoglobinopathies and Diabetes: Important Information for ... Rivella, S. (May 2009). "Ineffective erythropoiesis and thalassemias". Curr. Opin. Hematol. National Center for Biotechnology ... "Alpha thalassemia". Genetics Home Reference. U.S. National Library of Medicine. February 27, 2011. Retrieved 3 March 2011. " ...

https://en.wikipedia.org/wiki/List_of_hematologic_conditions

Alpha-thalassemia. Normal adult hemoglobin is composed of two alpha and two beta chains. Alpha thalassemia patients have ...

https://en.wikipedia.org/wiki/Heinz_body

August 1998). "Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major". The New ... Rund D, Rachmilewitz E (September 2005). "Beta-thalassemia". The New England Journal of Medicine. 353 (11): 1135-46. doi: ... double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major ... "An investigation into variability in the therapeutic response to deferiprone in patients with thalassemia major". Therapeutic ...

https://en.wikipedia.org/wiki/Gideon_Koren

Beta thalassemia is caused by mutations to or deletions of the HBB gene leading to reduced or absent synthesis of the beta ... 2014). "Initial Results from the Northstar Study (HGB-204): A Phase 1/2 Study of Gene Therapy for β-Thalassemia Major Via ... 2015). "Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and ... LentiGlobin BB305 is an experimental treatment for beta thalassemia, a rare and potentially debilitating blood disorder. It is ...

https://en.wikipedia.org/wiki/LentiGlobin_BB305

HBA2 Thalassemia, Hispanic gamma-delta-beta; 604131; LCRB Thalassemia-beta, dominant inclusion-body; 603902; HBB Thalassemias, ... ACAT1 Alpha-thalassemia myelodysplasia syndrome, somatic; 300448; ATRX Alpha-thalassemia mental retardation syndrome; 301040; ... alpha-; 604131; HBA1 Thalassemias, beta-; 604131; HBB Thanatophoric dysplasia, type I; 187600; FGFR3 Thiamine-responsive ... CYCS Thrombocytopenia with beta-thalassemia, X-linked; 314050; GATA1 Thrombocytopenia, congenital amegakaryocytic; 604498; MPL ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

"What is Thalassemia?". UCSF Benioff Children's Hospital. Retrieved March 8, 2017. "Symptoms and causes - Mayo Clinic". Mayo ... Furthermore, the large presence of thalassemia (Hb H), a disorder in which the alpha gene is dysfunctional, in Southeast Asia ...

https://en.wikipedia.org/wiki/Hemoglobin_Hopkins-2

When natural mutations occur in the promoter, β+ thalassemia can arise in humans. Thalassemia's prevalence (2 million worldwide ... About Thalassemia [Internet]. New York, NY: Cooley's Anemia Foundation National Office; 2001 [1 August 2007] . Available from: ... Perkins, Andrew; Sharpe, Ariene; Orkin, Stuart (1995). "Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription ...

https://en.wikipedia.org/wiki/KLF1

... thalassemia). Thus, some hemoglobinopathies are also thalassemias, but most are not. Either hemoglobinopathy or thalassemia, or ... Thalassemias, in contrast, usually result in underproduction of normal globin proteins, often through mutations in regulatory ... "Hemoglobinopathies and Thalassemia". http://www.medicalassistantonlineprograms.org/. External link in ,website= (help) " ...

https://en.wikipedia.org/wiki/Hemoglobinopathy

Depending upon how the terms are being defined, thalassemia can be considered a cause of microcytic anemia, or it can be ... Microcytic anemia is not caused by reduced DNA synthesis[citation needed]. Thalassemia can cause microcytosis. ...

https://en.wikipedia.org/wiki/Microcytosis

with G.I. Abu-Haydar and N.A. Abu-Haydar) "Thalassemia Hemoglobin E. Disease. A Case Report from Quatar." Persian Gulf, Man., ... "Iron Absorption in Thalassemia." Abstr. IXth Congr. Int. Soc. Haemat. (Stockholm, 1964.) Mishalany, H (April 1973). "Professor ...

https://en.wikipedia.org/wiki/Munib_Shahid

"Thalassemia: The growing challenge". Deccan Chronicle. "Thalassemia day care centre opened". The New Indian Express. 25 August ... "Hope for Bengaluru kids with thalassemia". The Times of India. 28 August 2015. "MY Hospital eyes high rate of success in BMT". ... It is a youth organisation working for blood donation, thalassemia and disaster relief. Since 2003, it has been working for ... AmeriCares India Jury's Choice 'Spirit of Humanity Awards' 2011 AmeriCares India Winner in Thalassemia category at 'Spirit of ...

https://en.wikipedia.org/wiki/Sankalp_India_Foundation

... making the baby a silent alpha thalassemia carrier, two alpha globin gene deletions (alpha thalassemia), or hemoglobin H ... "Pathophysiology of alpha thalassemia". www.uptodate.com. Retrieved 2016-08-30. F. P. van der Dijs, M. Volmer, D. G. van Gijssel ... It is produced in the disease alpha-thalassemia and in the most severe of cases, it is the only form of haemoglobin in ... Since hemoglobin Barts is elevated in alpha thalassaemia, it can be measured, providing a useful screening test for this ...

https://en.wikipedia.org/wiki/Hemoglobin_Barts

... is a type of alpha thalassemia caused by impaired production of three of the four alpha globins, coded by ... "Pathophysiology of alpha thalassemia". www.uptodate.com. Retrieved 2016-08-30. ...

https://en.wikipedia.org/wiki/Hemoglobin_H_disease

Diamond was researching the Beta Thalassemia genetic trait, which he suspected was present in Ashkenazi Jewish families in his ... Diamond, Stanley M. (3 August 2004). "About the beta-thalassemia project". DiamondGen. Retrieved 14 March 2016. Burstein, ...

https://en.wikipedia.org/wiki/JRI-Poland

... thalassemia; (g) genetically, e.g. Huntington's disease, cystic fibrosis; and (h) syndrome, e.g. migraine, torticollis, ...

https://en.wikipedia.org/wiki/Thomas_Szasz

suggested a prenatal genetic test for Thalassemia that did not rely upon DNA sequencing-then in its infancy-but on restriction ... In 2012, molecular diagnostic techniques for Thalassemia use genetic hybridization tests to identify the specific single ... "Molecular Diagnostics of β-Thalassemia". Balkan Journal of Medical Genetics. 15 (Suppl): 61-5. doi:10.2478/v10034-012-0021-z ( ...

https://en.wikipedia.org/wiki/Molecular_diagnostics

Progress in the management of thalassemia". Indian pediatrics. 43 (6). PMID 16820659. ...

https://en.wikipedia.org/wiki/Shantilal_C._Sheth

"Care at hand for thalassemia patients". Times Of India. 2013-08-25. Retrieved 2013-10-30. ...

https://en.wikipedia.org/wiki/Rashtrottahana_Parishat

Osseous: hyperparathyroidism, thalassemia, Melnick-Needles syndrome. Potential causes of superior rib notching include: ...

https://en.wikipedia.org/wiki/Notching_of_the_ribs

GeneReviews/NCBI/NIH/UW entry on Alpha-Thalassemia X-Linked Mental Retardation Syndrome; ATRX Syndrome; Alpha Thalassemia/ ... Gibbons RJ, Suthers GK, Wilkie AO, Buckle VJ, Higgs DR (November 1992). "X-linked alpha-thalassemia/mental retardation (ATR-X) ... Alpha-thalassemia mental retardation syndrome GRCh38: Ensembl release 89: ENSG00000085224 - Ensembl, May 2017 GRCm38: Ensembl ... "Entrez Gene: ATRX alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)". Wong LH, McGhie JD, ...

https://en.wikipedia.org/wiki/ATRX

"Thalassaemia Welfare Society". Thalassaemia Welfare Society. Retrieved May 26, 2015. "Rotary club enters into a MOU". The Hindu ... Revathi Raj, a paediatric haematologist has established the Thalassaemia Welfare Association in VHS with assistance from TTK ... The centre provides patients afflicted with thalassemia with free blood transfusions, iron chelation therapy and consultative ...

https://en.wikipedia.org/wiki/Voluntary_Health_Services

E-thalassaemia disease". Indian J Med Res. 59 (9): 1430-4. PMID 5161569. CS1 maint: Multiple names: authors list (link) Swarup- ... E-thalassaemia disease". Indian J Pathol Bacteriol. 16 (4): 41-5. PMID 4791521. CS1 maint: Multiple names: authors list (link) ... He was known for his hematological and clinical studies of Hemoglobin E/β-thalassaemia and was an elected fellow of the ... biophysical and the genetical studies of Hemoglobin E/β-thalassaemia prevalent in Bengal region. He documented his researches ...

https://en.wikipedia.org/wiki/Jyoti_Bhusan_Chatterjea

Thalassaemia Society of Pakistan Provide the best care and treatment for children with thalassaemia Create awareness about ... Andleeb is Vice President of Thalassaemia Society of Pakistan established in 1994, setting up the first thalassaemia center in ... http://dailytimes.com.pk/search/test/%C2%A0/464/Andleeb%20Abbas "Thalassaemia Pakistan". Thalassaemia.org.pk. Retrieved 2017-05 ... thalassaemia Prevention through prenatal diagnosis She is also a Co founder of Pani Pakistan-A foundation to deal with ...

https://en.wikipedia.org/wiki/Andleeb_Abbas

β-thalassemia, one of the most common congenital anemias, arises from partial or complete lack of β-globin synthesis. Excessive ... Patients with β-thalassemia also have low hepcidin levels. The observations led researchers to hypothesize that more iron is ... Moura IC, Hermine O (2015). "Erythroferrone: the missing link in β-thalassemia?". Blood. 126 (17): 1974-5. doi:10.1182/blood- ... absorbed in β-thalassemia than is required for erythropoiesis. Increasing expression of hepcidin in β-thalassemic mice limits ...

https://en.wikipedia.org/wiki/Hepcidin

These disorders include sickle cell-beta thalassemia. In the case of sickle cell anemia, an individual with one allele for ... 1988). "Clinical and genetic heterogeneity in black patients with homozygous beta-thalassemia from the southeastern United ...

https://en.wikipedia.org/wiki/Compound_heterozygosity

GeneCard for CXorf26 Aceview Gene Annotation Stevenson RE (2000). "Alpha-Thalassemia X-Linked Intellectual Disability Syndrome ... and when mutated causes an X-linked mental retardation syndrome along with alpha thalassemia syndrome; both are known to cause ...

https://en.wikipedia.org/wiki/PBDC1

Beta thalassemias (β thalassemias) are a group of inherited blood disorders. They are forms of thalassemia caused by reduced or ... Alpha-thalassemia Advani, Pooja. "Beta Thalassemia Treatment & Management". Medscape. Retrieved 4 April 2017. "Beta thalassemia ... Three main forms have been described: thalassemia major, thalassemia intermedia, and thalassemia minor. All people with ... 20 people die per year causing thalassemia to be listed as a "rare disease". In the United States, thalassemias prevalence is ...

https://en.wikipedia.org/wiki/Beta_thalassemia

... is a blood disorder in which the body has a problem producing alpha globin, a component of hemoglobin, the ... Alpha thalassemia: when the body has a problem producing alpha globin. *Beta thalassemia: when the body has a problem producing ... Complications of alpha thalassemia include:. *Excess iron. When children have alpha thalassemia, they can end up with too much ... About Alpha Thalassemia. Normally, each person has four genes for alpha globin. Alpha thalassemia happens when one or more of ...

http://kidshealth.org/PrimaryChildrens/en/parents/thalassemias.html

... α-thalassemia) syndromes are a group of hereditary anemias of varying clinical severity. They are characterized by reduced or ... thalassemia (-α/-α) results in the development of alpha thalassemia trait, also referred to as alpha thalassemia minor or alpha ... Thalassemia is one of the worlds most common single-gene disorders. Individuals with thalassemia syndrome are most often of ... Management of alpha thalassemia. Individuals with mild forms of alpha thalassemia may not require specific treatment except as ...

https://emedicine.medscape.com/article/955496-overview

THALASSEMIA. Definition: Thalassemia is a blood disorder that is inherited through a defect in a gene that aids in the ... Alpha thalassemia occurs most often in people from Southeast Asia, the Middle East, China, and North Africa. Beta thalassemia ... Severe thalassemia can cause early death (between ages 20-30) from heart failure. Untreated thalassemia major can lead to: ... Thalassemia major. : development of severe anemia early in life and cannot produce adult hemoglobin. 2. Thalassemia minor. : ...

https://prezi.com/b7d3vjbnmz6n/thalassemia/

Thalassemia and sickle cell society of Bangalore hosted a session on clinical updates on thalassemia by leading hematology ... Thalassemia. Thalassemia is an inherited blood disorder passed on through parental genes causing the body to produce abnormal ... Thalassemia and sickle cell society of Bangalore was host to a presentation on the clinical updates on thalassemia by leading ... Thalassemia and sickle cell society of Bangalore hosted a session on clinical updates on thalassemia by leading hematology ...

http://www.medindia.net/news/healthinfocus/clinical-update-on-current-management-of-thalassemia-173654-1.htm

Alpha Thalassemia in Children. What is alpha thalassemia in children?. Alpha thalassemia is an inherited blood disorder. This ... Alpha thalassemia is caused by defects in the genes that control hemoglobin production. There are 3 types: *Alpha thalassemia ... Alpha thalassemia affects the production of hemoglobin. There are different types of thalassemia. The severity of anemia ... What are the symptoms of alpha thalassemia in a child?. Symptoms of alpha thalassemia are from anemia. They range from mild to ...

https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=90&ContentID=P02329

For important test information about 23andMes Beta Thalassemia and Related Hemoglobinopathies Carrier Status report, visit ... Learn more about the genetics of beta thalassemia and related hemoglobinopathies. ... Beta Thalassemia and Related Hemoglobinopathies What is beta thalassemia? Beta thalassemia is a genetic disorder characterized ... Causes of beta thalassemia Beta thalassemia and related hemoglobinopathies are caused by variants (differences) in the HBB gene ...

https://www.23andme.com/en-eu/topics/carrier/beta-thalassemia/

The spectrum of thalassemias is wide, with one end comprising thalassemia minor, which co ... Beta-thalassemia is due to a defect in the synthesis of the beta-globin chains, leading to alpha/beta imbalance, ineffective ... Globin synthesis in thalassaemia: an in vitro studyNatureYear: 1965208106110655870556. 6. Weatherall DJ. The thalassemia ... Thalassemia intermediaHaematologicaYear: 19958058687758995. 17. Cappellini MD,Cerino M,Marelli S,Fiorelli G. Thalassemia ...

http://www.biomedsearch.com/nih/Thalassemia-Intermedia-Birds-Eye-View/24764724.html

In the thalassemia model, a near-complete phenotypic correction was achieved. The treatment was well tolerated. This cost- ... Current thalassemia gene therapy protocols require the collection of hematopoietic stem/progenitor cells (HSPCs), in vitro ... We showed in "healthy" human CD46-transgenic mice and in a mouse model of thalassemia intermedia that our in vivo approach ... HDAd5/35++ vectors for in vivo gene therapy of thalassemia had a unique capsid that targeted primitive HSPCs through human CD46 ...

https://www.jci.org/articles/view/122836/figure/2

Get Thalassemia todays top breaking news headlines, photos & videos on Midday. ... Thalassemia Latest News, Photos & Videos: Find out what's happening around the world. ... A devastated father is taking his two-year-old Thalassemia affected daughter to a graveyard everyday he has dug for her, so ... Bebo, a 5-year-old girl from Agra, has has been suffering from Thalassemia for the last 3 years ...

http://www.mid-day.com/search/thalassemia-all

1. thalassemia major (n.). a fatal form of homozygous thalassemia (inherited from both parents) in which there is no hemoglobin ...

http://www.synonym.com/synonyms/thalassemia%20major

... to believe that one out of ten of the total dental patients that gets treated in UAE dental clinic are affected by thalassemia ... Thalassemia is form of inherited autosomal recessive blood disorders, and could be classified in to thalassemia alpha and beta ... Thalassemia beta major has specific skeletal, facial and oral manifestation which needs specific precautions during dental and ... Dental & orthodontic management of thalassemia patient. 2nd International Conference and Exhibition on Dental & Oral Health. ...

https://www.omicsonline.org/proceedings/dental--orthodontic-management-of-thalassemia-patient-16887.html

an α thalassemia trait or a beta-thalassemia trait. Distinction between these may need further tests such as measurement of the ... Question: Elevated RBC related to Thalassemia trait?. Worthington - Thu Jul 29, 2010 4:04 pm. Share , ... Both will be increased in beta thalassemia trait without iron deficiency, and will be normal or decreased in alpha thalassemia ... seen to be consistently low in heterozygous alpha-1 thalassemia but not in heterozygous alpha-2 thalassemia).. You perhaps need ...

https://www.doctorslounge.com/hematology/forums/backup/topic-48991.html

View messages from patients providing insights into their medical experiences with Alpha Thalassemia - Symptoms. Share in the ... Thanks to God my first two boys is thalassemia free and my third born (a girl) is also beta thalassemia just like me. My little ... I found out I had alpha thalassemia trait when I was 21. My mom and sister got tested too, and they both have it. We are of ... I have alpha thalassemia trait, which was diagnosed when I was expecting my first child. Many blood tests were done, and by the ...

https://www.medicinenet.com/alpha_thalassemia/patient-comments-834.htm

To date TIF represents hundreds of thousands of patients with thalassaemia from 108 Nationals Thalassaemia Associations in 60 ... we interview Dr Androulla Eleftheriou on the topic of thalassaemia prevention and the work of the The Thalassaemia ... "Thalassaemia patients need to educate themselves in order to be able to claim their civil rights for access to quality ... AE: Patients with thalassaemia need to be knowledgeable about their rights as well as their disease and its treatment. They ...

https://pharmaphorum.com/views-and-analysis/thalassaemia_prevention/

The aims and objectives of the UK Thalassaemia Society are the relief of persons suffering from Thalassaemia, the promotion and ... co-ordination of research in connection with Thalassaemia, to educate people on the problems of Thalassaemia, to offer ...

https://www.barnet.gov.uk/directories/directme/uk-thalassaemia-society

Locations and contact information for each of the thalassemia treatment centers previously funded by CDC. ... Selected Thalassemia Treatment Centers. The Childrens Hospital of Bostonexternal icon. Director: Erica Esrick, MD. Contact: ... Penn Comprehensive Adult Thalassemia Program, Hospital of the University of Pennsylvaniaexternal icon. Director: Farzana Sayani ... Northern California Comprehensive Thalassemia Centerexternal icon. Director Elliott Vichinsky, MD. Contact: Raquel Manzo. (510 ...

https://www.cdc.gov/ncbddd/thalassemia/centers.html

For people living with thalassemia, it is especially important to know that a healthy lifestyle means ... In addition, if you have thalassemia, thalassemia trait, or know someone in your family with thalassemia, genetic counseling is ... Managing Thalassemia. Thalassemia is a treatable disorder that can be well-managed with blood transfusions and chelation ... Healthy Choices for People Living with Thalassemia. Other healthy choices a person with thalassemia should consider include ...

https://www.cdc.gov/ncbddd/thalassemia/living.html

There are two main types, alpha thalassemia and beta thalassemia. The severity of alpha and beta thalassemia depends on how ... it is clinically similar to β thalassemia major or thalassemia intermedia.[citation needed] Hemoglobin S/thalassemia: common in ... In α-thalassemias, production of the α globin chain is affected, while in β-thalassemia, production of the β globin chain is ... β-Thalassemias are not only common in Africans, but also in Greeks and Italians. The α-thalassemias involve the genes HBA1 and ...

https://en.wikipedia.org/wiki/Thalassemia

There are two basic groups of thalassemia disorders: alpha thalassemia and beta thalassemia. ... Thalassemia Definition Thalassemia describes a group of inherited disorders characterized by reduced or absent amounts of ... Thalassemia Gale Encyclopedia of Medicine, 3rd ed. COPYRIGHT 2006 Thomson Gale. Thalassemia. Definition. Thalassemia describes ... Beta thalassemia Beta thalassemia may be the most best-known type of thalassemia and is also called Cooleys anemia. It is ...

https://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/thalassemia

Beta thalassemia is a blood disorder that reduces the production of hemoglobin. Explore symptoms, inheritance, genetics of this ... Thalassemia intermedia is milder than thalassemia major. The signs and symptoms of thalassemia intermedia appear in early ... thalassemia major (also known as Cooleys anemia) and thalassemia intermedia. Of the two types, thalassemia major is more ... Thalassemia major and thalassemia intermedia are inherited in an autosomal recessive pattern. , which means both copies of the ...

https://medlineplus.gov/genetics/condition/beta-thalassemia/

The treatment for thalassemia can vary greatly according to the individual circumstances and the presenting symptoms. Some ... For severe cases of thalassemia, a stem cell or bone marrow transplant may offer a benefit. This is reserved as a last-line ... The treatment for thalassemia can vary greatly according to the individual circumstances and the presenting symptoms. Some ... Overload of iron is a common issue for people with thalassemia and many patients require treatment to manage this, as it can ...

https://www.news-medical.net/health/Thalassemia-Treatment.aspx

Thalassemia affects approximately 4.4 of every 10,000 live births throughout the world. It causes males and females to inherit ... Alpha-Thalassemia. Alpha-thalassemia is particularly common among populations of Southeast Asian descent, and there are a high ... Beta-Thalassemia. Beta-thalassemia is most common among populations of Mediterranean, African and South Asian ancestry. The ... All types of thalassemia can be fatal in some cases, particularly when there are multiple gene mutations that affect the ...

https://www.news-medical.net/health/Thalassemia-Prevalence.aspx

Blood transfusions are part of the treatment routine for some people with a blood disorder called beta thalassemia. Learn when ... Blood Transfusions for Beta Thalassemia. Blood transfusions could be a regular thing if you or your child has a blood disorder ... Beta thalassemia lowers your hemoglobin -- a protein that helps red blood cells carry oxygen to your organs and tissues -- and ... If youre the parent of a child with beta thalassemia, its important to find support for the emotions you may feel as you help ...

https://www.webmd.com/a-to-z-guides/beta-thal-19/beta-thalassemia-blood-transfusions

A person may have alpha or beta thalassemia, and symptoms depend on these types and how many mutated genes a person has ... Thalassemia is an inherited blood disorder. It inhibits the production of hemoglobin and red blood cells. ... About thalassemia. (n.d.). Retrieved from http://www.thalassemia.org/learn-about-thalassemia/about-thalassemia/ ... The symptoms of thalassemia vary depending on the type of thalassemia.. Symptoms will not show until the age of 6 months in ...

https://www.medicalnewstoday.com/articles/263489.php

... is this because of thalassemia or do i suffer from something else ... I suffer from thalassemia minor i know my haemoglobin is ... With Thalassemia Minor you will have mild to moderate anemia due to the abnormal formation of some hemoglobin but not all. You ... I suffer from thalassemia minor i know my haemoglobin is abnormally shaped but recently a blood test had shown low haemoglobin ... There is literature recommending that people with Thalassemia Minor can consume iron rich foods to help increase their ...

https://www.medhelp.org/posts/Nutrition/thalassemia--minor-/show/628548

Bone marrow transplants may cure many sufferers of beta thalassemia, a fatal illness of young adults brought on by a genetic ... Bone marrow transplants may cure many sufferers of beta thalassemia, a fatal illness of young adults brought on by a genetic ... The technique, a radical procedure commonly used to treat some deadly forms of cancer, was pioneered as a thalassemia treatment ...

http://articles.latimes.com/1990-02-19/local/me-842_1_beta-thalassemia

10,000 to 15,000 babies with thalassemia major are born in India every year and about 1 to 1.5 lakh thalassemia patients are ... Borgna-Pignatti C. The life of patients with thalassemia major. Haematologica. 2010;95:345-8.CrossRefPubMedPubMedCentralGoogle ... Thalassemia. In: Gupta P, Menon PSN, Ramji S, Lodha R, editors. PG Textbook of Pediatric. Vol 2. Delhi: Jaypee Brothers Medical ... A large number of publications have appeared on various aspects of thalassemia management and control [8, 9] but there is... ...

https://link.springer.com/article/10.1007/s12098-018-2642-z

Learn about symptoms, treatment, who is a carrier, and diagnosis for beta thalassemia. ... Beta thalassemia is a group of genetic blood disorders that share in common the defective production of hemoglobin, similar to ... Thalassemia patients make defective hemoglobin.. *There are two forms of beta thalassemia: thalassemia minor and thalassemia ... Thalassemia minor: The individual with thalassemia minor has only one copy of the beta thalassemia gene (together with one ...

https://www.medicinenet.com/beta_thalassemia/article.htm

There are two main types of thalassemia: alpha and beta. Different genes are affected for each type. Thalassemia can cause mild ... Thalassemia is an inherited blood disorder. It is passed down from one or both parents through their genes. ... Alpha Thalassemia. Facebook Twitter Linkedin Pinterest Print. What is alpha thalassemia?. Thalassemia (thal-uh-SEE-mee-uh) is a ... What causes alpha thalassemia?. Alpha thalassemia occurs when some or all of the 4 genes that make hemoglobin (the alpha-globin ...

https://www.hopkinsmedicine.org/health/conditions-and-diseases/alpha-thalassemia

There are two main types of thalassemia: alpha and beta. Thalassemia can cause mild or severe anemia. ... Thalassemia is an inherited blood disorder that is passed down through the parents genes. ... Beta Thalassemia. Facebook Twitter Linkedin Pinterest Print. What is beta thalassemia?. Thalassemia (thal-uh-SEE-mee-uh) is a ... What are the complications of beta thalassemia?. Complications of beta thalassemia vary depending on the type:. * Thalassemia ...

https://www.hopkinsmedicine.org/health/conditions-and-diseases/beta-thalassemia

Read about the main treatments for thalassaemia, including blood transfusions, medication to remove excess iron from the body ... The main treatments for thalassaemia are:. Blood transfusions. Most people with thalassaemia major or other severe types will ... Thalassaemia can also cause a number of other problems that may need to be managed. For example:. *hormone medication may be ... Thalassaemia usually requires lifelong treatment with blood transfusions and medication.. Children and adults with the ...

https://www.nhs.uk/conditions/thalassaemia/treatment/

Helping you find trustworthy answers on Thalassemia , Latest evidence made easy ... Find all the evidence you need on Thalassemia via the Trip Database. ... Thalassemia review: features, dental considerations and management (PubMed). Thalassemia review: features, dental ... 7. Double heterozygocity for hemoglobin C and beta thalassemia dominant: A rare case of thalassemia intermedia (PubMed). Double ...

https://www.tripdatabase.com/search?criteria=Thalassemia

However, thalassemia can live and grow into adulthood there is no real cure for thalassemia except bone marrow transplant. It ... When both parents are thalassemia miners or carriers, there is a 25% chance of birth of a thalassemia major child 25% of a ... The types of thalassemia depends on inheritance of gene mutation from parents. The severity of thalassemia depends on the ... There are two types of Thalassemia minor and major. Minors are people who carry one defective thalassemia gene they are normal ...

http://www.sooperarticles.com/health-fitness-articles/blood-cancer-articles/types-thalassemia-1601760.html

Cell-Free Hemoglobin Synthesis in Beta-Thalassemia. J. M. Gilbert, A. G. Thornton, A. W. Nienhuis, and W. F. Anderson ... Induction of β-Globin Synthesis in the β-Thalassaemia of Ferrara. FRANCESCO CONCONI, PETER T. ROWLEY, LAURA DEL SENNO, SANDRO ... Initiation of Globin Synthesis in β-Thalassemia. Ronald G. Crystal, Norton A. Elson, Arthur Nienhuis, Abigail C. Thornton, W. ... Decreased α Globin Messenger RNA Activity associated with Polyribosomes in α Thalassaemia ...

https://www.pnas.org/content/67/4/1854/tab-article-info

Thalassemia major definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ... A usually fatal form of thalassemia appearing in infancy or childhood in which normal hemoglobin is absent, characterized by ...

https://www.dictionary.com/browse/thalassemia-major

Thalassemia can be inherited from two normal, yet thalassemia trait carrier (thalassemia Gowdais and Lingayat s from Karnataka ... It is important to identify yourself as possible carrier of thalassemia (thalassemia minor). A person with thalassemia minor ... Thalassemia is 99% not curable but 100% preventable? So get tested and have your THALASSEMIA STATUS REPORT before you tie the ... In children who do, symptoms of thalassemia can range from mild to severe depending on the type of thalassemia they are ...

https://www.change.org/p/thalassemia-child-welfare-group-indore

... α-thalassemia) syndromes are a group of hereditary anemias of varying clinical severity. They are characterized by reduced or ... Alpha Thalassemia Medication. Updated: Oct 16, 2018 * Author: Alexandra C Cheerva, MD, MS; Chief Editor: Hassan M Yaish, MD ... Alpha thalassaemia in tribal communities of coastal Maharashtra, India. Indian J Med Res. 2014 Aug. 140(2):231-7. [Medline]. [ ... Alpha-thalassemia: Hb H disease and Hb Barts hydrops fetalis. Ann N Y Acad Sci. 2005. 1054:25-32. [Medline]. ...

https://emedicine.medscape.com/article/955496-medication

Thalassemia - Learn more about symptoms, causes, treatment of this inherited blood disorder that usually shows up before 2 ... Factors that increase your risk of thalassemia include:. *Family history of thalassemia. Thalassemia is passed from parents to ... Several types of thalassemia exist, including alpha-thalassemia, thalassemia intermedia and Cooley anemia. The signs and ... In most cases, you cant prevent thalassemia. If you have thalassemia, or if you carry a thalassemia gene, consider talking ...

https://www.mayoclinic.org/diseases-conditions/thalassemia/symptoms-causes/syc-20354995?footprints=mine

Alpha Thalassemia. What is alpha thalassemia?. Thalassemia is a blood disorder that is inherited. This means it is passed down ... What causes alpha thalassemia?. Alpha thalassemia occurs when one or more of the 4 alpha-globin genes that make up part of the ... Silent alpha thalassemia carrier. This type has no symptoms. * Alpha thalassemia carrier. You may have mild anemia. You may ... Living with alpha thalassemia. People with alpha thalassemia may have no symptoms. Or they may have many symptoms. If you dont ...

https://www.uhhospitals.org/health-information/health-and-wellness-library/adult-diseases-and-conditions/article/diseases-and-conditions/alpha-thalassemia

Molecular basis for dominantly inherited inclusion body ß-thalassemia. Proc Natl Acad Sci USA. 1990;87:3924-3928.CrossRefPubMed ... Is it dominantly inherited ß thalassaemia or just a ß-chain variant that is highly unstable? Br J Haematol. 1999;107:12-21. ... Ohba Y, Hattori Y, Harano T, Harano K, Fukumaki Y, Ideguchi H. ß-Thalassemia mutations in Japanese and Koreans. Hemoglobin. ...

https://link.springer.com/article/10.1532/IJH97.04048

... thalassemia in San Raffaele Telethon Institute of Gene Therapy-Beta Thalassemia (TIGET-BTHAL) Study. *Beta Thalassaemia ... Long Term Outcomes in β Thalassemia Major. *Thalassemia Major. Observational. *Ann & Robert H Lurie Children's Hospital of ... Effect of Antioxidant Cocktail in Beta-thalassemia/Hb E Patients. *Thalassemia. *Drug: curcuminoids, N-acetylcysteine, ... Complications in Children With B- Thalassemia Major. *Beta-thalassemia. *Other: Demographic, physical examination, data will ...

https://clinicaltrials.gov/ct2/results?cond=%22Thalassemia%22&show_rss=Y&sel_rss=mod14

Most children with alpha thalassemia trait don't need treatment. (rochester.edu)
Elevated RBC related to Thalassemia trait? (doctorslounge.com)
I would like to know if my elevated RBC count is cause for concern or simply a result from my low MVC and MCH, probably due to having Thalassemia trait? (doctorslounge.com)
The distinguishing finding in beta thalassemia is a hemoglobin electrophoresis with the finding of elevated minor hemoglobins Hgb A2 and F. Both will be increased in beta thalassemia trait without iron deficiency, and will be normal or decreased in alpha thalassemia and isolated iron deficiency anemia . (doctorslounge.com)
I found out I had alpha thalassemia trait when I was 21. (medicinenet.com)
I did a search of " blood disorders that affect blacks" I came across alpha thalassemia and asked my medical team about being tested and the results were positive for alpha thalassemia trait/minor. (medicinenet.com)
I have alpha thalassemia trait, which was diagnosed when I was expecting my first child. (medicinenet.com)
From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. (healthtap.com)
Thalassemia carriers (thalassemia trait) probably have the same chance of hearing problems as non-thalassemia persons have. (healthtap.com)
Does alpha thalassemia trait have gene therapy available? (healthtap.com)
Alpha thalassemia trait only causes mild anemia , and the person usually has no symptoms. (healthtap.com)
What is thalassemia and thalassemia trait? (healthtap.com)
Thalassemia trait is a genetic possibility you pass on to your offspring. (healthtap.com)
The most important reason for discovering if you carry the thalassemia trait is this: if two people who each. (healthtap.com)
In Beta thalassemia there is an abnormality in the production of beta chains which causes the red cells to more easily breakdown resulting in mild to severe anemia (low red blood cell count) depending on the type that is present (Major type-Cooley's anemia / Intermediate type/ or Thalassemia minor or thalassemia trait). (nicklauschildrens.org)
Age of presentation and symptoms of beta thalassemia will depend on the type (Major/Intermediate or Trait) of thalassemia. (nicklauschildrens.org)

Three main forms have been described: thalassemia major, thalassemia intermedia, and thalassemia minor. (wikipedia.org)
These complications are mostly found in thalassemia major and intermedia patients. (wikipedia.org)
We showed in "healthy" human CD46-transgenic mice and in a mouse model of thalassemia intermedia that our in vivo approach resulted in stable γ-globin expression in the majority of circulating red blood cells. (jci.org)
A young female diagnosed with Thalassemia Intermedia (TI) was referred for severe anemia, marked jaundice, epigastric pain, dyspnoea, fever and edema feet. (scitechnol.com)
The patient was diagnosed as Hb-E β Thalassemia Intermedia (TI) during childhood. (scitechnol.com)
Design and Methods: We describe the methods of conception and delivery, as well as the course and outcome of pregnancy including transfusions, iron overload and chelation in 46 women with thalassemia major (58 pregnancies) and in 11 women with thalassemia intermedia (17 pregnancies). (unica.it)
Conception was achieved after gonadotrophin-induced ovulation in 33 of the women with thalassemia major and spontaneously in all of those with thalassemia intermedia. (unica.it)
Pregnancy was safe in most women with thalassemia major or intermedia. (unica.it)
However, women with thalassemia intermedia who had never previously been transfused or who had received only minimal transfusion therapy were at risk of severe alloimmune anemia if blood transfusions were required during pregnancy. (unica.it)

They are forms of thalassemia caused by reduced or absent synthesis of the beta chains of hemoglobin that result in variable outcomes ranging from severe anemia to clinically asymptomatic individuals. (wikipedia.org)
Beta thalassemia is a hereditary disease affecting hemoglobin. (wikipedia.org)
Workup in alpha thalassemia relies primarily on laboratory evaluation, hemoglobin electrophoresis, and genetic testing (alpha thalassemia mutations panel). (medscape.com)
Alpha thalassemia combined with sickle-cell anemia results in a higher hemoglobin concentration and improved RBC survival. (medscape.com)
Definition: Thalassemia is a blood disorder that is inherited through a defect in a gene that aids in the production of alpha globin or beta globin proteins, found in Hemoglobin. (prezi.com)
Alpha thalassemia affects the production of hemoglobin. (rochester.edu)
Alpha thalassemia is caused by defects in the genes that control hemoglobin production. (rochester.edu)
Thalassaemia is a rare, non-malignant haematological, genetic disorder in which the body makes an abnormal form of hemoglobin. (pharmaphorum.com)
Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin, the disorder results in excessive destruction of red blood cells, which leads to anemia . (healthtap.com)
When an individual has beta thalassemia, their red blood cells do not have enough hemoglobin in them that is responsible for delivering oxygen throughout the body. (nicklauschildrens.org)
People with beta thalassemia have reduced levels of hemoglobin, the ferrous protein in blood that transports oxygen around the body. (patientworthy.com)
Since many beta thalassemia patients have to undergo frequent blood transfusions to manage their condition, the development of a drug that could effectively stabilize their hemoglobin and platelet levels would be a huge breakthrough. (patientworthy.com)

Individuals with beta thalassemia major usually present within the first two years of life with severe anemia, poor growth, and skeletal abnormalities during infancy. (wikipedia.org)
severe anemia -recessive gene inherited condition -alpha thalassemia caused by either a genetic mutation or a deletion of certain key genes. (prezi.com)
Symptoms of alpha thalassemia are from anemia. (rochester.edu)
Beta thalassemia is a genetic disorder characterized by anemia and fatigue as well as bone deformities and organ problems. (23andme.com)
Hi, Iron deficiency is the most common acquired cause of anemia and Thalassemia is perhaps the most frequent gene mutation in human beings. (doctorslounge.com)
Differentiating iron deficiency anemia and thalassemias (with their very heterogeneous nature) has remained challenging. (doctorslounge.com)
However, thalassemia patients with severe anemia who need regular blood transfusions will get iron overload. (healthtap.com)
A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia , and also inherited one gene mutation for beta thalassemia. (healthtap.com)
Beta thalassemia major is also called Cooley anemia. (baptistjax.com)
Children born with beta thalassemia major (Cooley anemia) are normal at birth, but develop severe anemia during the first year of life. (baptistjax.com)
In the case of beta thalassemia major, the anemia can become life threatening. (nicklauschildrens.org)
An eighteen years old single female, a resident of interior areas of Maharashtra (Palghar), belonging to the Muslim community and BONCM was referred from peripheral hospital to our emergency medical services (tertiary hospital) with the diagnosis of Thalassemia with severe anemia, jaundice, and sepsis. (scitechnol.com)

Genetic testing is currently available to establish the diagnosis of alpha thalassemia and clarify the genetic abnormalities in patients with a family history or laboratory results suggestive of an alpha thalassemia syndrome. (medscape.com)
23andMe does not test for all possible genetic variants linked to beta thalassemia and related hemoglobinopathies, and individuals who have zero variants detected still have a chance of being a carrier for beta thalassemia and related hemoglobinopathies. (23andme.com)
The 23andMe Beta Thalassemia and Related Hemoglobinopathies Carrier Status report* looks at 10 genetic variants in the HBB gene linked to these conditions and is most relevant for people of Sardinian, Cypriot, Italian and Greek descent. (23andme.com)
Beta thalassemia is an inherited (from parents) genetic disease . (nicklauschildrens.org)
Thalassemia is a genetic blood disorder that causes an individual's body to create an abnormal form or an inadequate amount of haemoglobin, which directly results in the destruction of a large number of red blood cells in the body, thus the individual develops anaemia. (scit.edu)

Alpha thalassemia occurs when a gene or genes related to the alpha globin protein are missing or changed (mutated). (baptistjax.com)

Beta thalassemias are caused by mutations in the HBB gene on chromosome 11, inherited in an autosomal recessive fashion. (wikipedia.org)
Depending on your family history, if your parents or grandparents suffered from beta thalassemia there is a high probability of the mutated gene being inherited by an offspring. (wikipedia.org)
Thalassemia is one of the world's most common single-gene disorders. (medscape.com)
Mutations and gene deletions causing the various thalassemia genotypes have arisen independently in different populations but have subsequently propagated by means of natural selection. (medscape.com)
If both parents have the gene defect, each of their children has a risk of having alpha thalassemia major. (rochester.edu)
Beta thalassemia and related hemoglobinopathies are caused by variants (differences) in the HBB gene. (23andme.com)
The Beta Thalassemia and Related Hemoglobinopathies Carrier Status report is indicated for the detection of 10 of variants in the HBB gene and is most relevant for people of Sardinian, Cypriot, Italian, and Greek descent. (23andme.com)
Current thalassemia gene therapy protocols require the collection of hematopoietic stem/progenitor cells (HSPCs), in vitro culture, lentivirus vector transduction, and retransplantation into myeloablated patients. (jci.org)
HDAd5/35++ vectors for in vivo gene therapy of thalassemia had a unique capsid that targeted primitive HSPCs through human CD46, a relatively safe SB100X transposase-based integration machinery, a micro-LCR-driven γ-globin gene, and an MGMT(P140K) system that allowed for increasing the therapeutic effect by short-term treatment with low-dose O6-benzylguanine plus bis-chloroethylnitrosourea. (jci.org)
This cost-efficient and "portable" approach could permit a broader clinical application of thalassemia gene therapy. (jci.org)
Thalassemia occurs when there is a defect in a gene that helps control production of 1 of these proteins. (baptistjax.com)
Beta thalassemia occurs when similar gene defects affect production of the beta globin protein. (baptistjax.com)
You must inherit the gene defect from both parents to develop thalassemia major. (baptistjax.com)
Thalassemia minor occurs if you receive the faulty gene from only 1 parent. (baptistjax.com)

There are many forms of thalassemia. (baptistjax.com)
Less severe forms of thalassemia often do not shorten lifespan. (baptistjax.com)

The aims and objectives of the UK Thalassaemia Society are the relief of persons suffering from Thalassaemia, the promotion and co-ordination of research in connection with Thalassaemia, to educate people on the problems of Thalassaemia, to offer counselling to sufferers and carriers and to bring together patients, families and well-wishers to exchange ideas and information. (barnet.gov.uk)
Amid A, Haghi-Ashtiani B, Kirby-Allen M, Haghi-Ashtiani MT. Screening for thalassemia carriers in populations with a high rate of iron deficiency: revisiting the applicability of the Mentzer Index and the effect of iron deficiency on Hb A2 levels. (sickkids.ca)

Even if a child does not have beta thalassemia major, they can still be a carrier resulting in future offspring having beta thalassemia. (wikipedia.org)
You can find out whether you may be a carrier for beta thalassemia with 23andMe. (23andme.com)
Can an alpha thalassemia carrier marry a beta thalassemia carrier? (healthtap.com)

Individuals with thalassemia syndrome are most often of African, Asian, Mediterranean, or Middle Eastern descent. (medscape.com)
Beta thalassemia occurs in people of a Mediterranean origin. (prezi.com)
Alpha thalassemia is common throughout parts of the world where malaria is endemic and is common in people of Asian, African, and Mediterranean heritage. (doctorslounge.com)
Beta thalassemias occur most often in people of Mediterranean origin. (baptistjax.com)

Background: Recent advances in the management of thalassemia have significantly improved life expectancy and quality of life of patients with this hemoglobinopathy, with a consequent increase in their reproductive potential and desire to have children. (unica.it)

Treatment depends on the type of alpha thalassemia. (rochester.edu)
Complications also depend on the type of alpha thalassemia. (rochester.edu)

Severe thalassemia can cause early death (between ages 20-30) from heart failure. (prezi.com)

What causes alpha thalassemia in a child? (rochester.edu)

The alpha thalassemia (α-thalassemia) syndromes are a group of hereditary anemias of varying clinical severity. (medscape.com)
[ 10 ] Individuals with beta thalassemia syndromes have somewhat better protection against malaria than individuals with alpha thalassemia syndromes. (medscape.com)
Giardina PJ, Rivella S. Thalassemia syndromes. (baptistjax.com)

this leads to the clinical disease known as alpha thalassemia. (medscape.com)
The Thalassaemia International Federation (TIF) strives to achieve such commitment with the aim to develop and implement national control programmes for the prevention and clinical management of thalassaemia, across all affected countries. (pharmaphorum.com)
Our overall mission is the development and implementation of national control programmes for the prevention and clinical management of thalassaemia, across all affected countries. (pharmaphorum.com)

Symptoms of beta thalassemia and related hemoglobinopathies typically develop any time from late infancy (severe form) into adulthood (intermediate form). (23andme.com)

Thalassemia is form of inherited autosomal recessive blood disorders, and could be classified in to thalassemia alpha and beta which is in turn classified in to minor and major. (omicsonline.org)

Affected people are at increased risk for having a child with alpha thalassemia major. (rochester.edu)

Patients with severe thalassaemia major suffer endocrine and other abnormalities before their eventual death from iron overload due to repeated blood transfusions. (bmj.com)
Treatment for thalassemia major often involves regular blood transfusions and folate supplements. (baptistjax.com)
She was on RBC transfusions and was following up at the thalassemia center. (scitechnol.com)
She used to get blood units for transfusions from a blood bank and was following up at Thalassemia center. (scitechnol.com)

Beta thalassemias (β thalassemias) are a group of inherited blood disorders. (wikipedia.org)
Increased gastrointestinal iron absorption is seen in all grades of beta thalassemia and increased red blood cell destruction by the spleen due to ineffective erythropoiesis further releases additional iron into the bloodstream. (wikipedia.org)
Alpha thalassemia is an inherited blood disorder. (rochester.edu)
Many blood tests were done, and by the eighth month of my pregnancy , they declared that I am suggestive of alpha thalassemia. (medicinenet.com)
People with the minor form of alpha and beta thalassemia have small red blood cells but no symptoms. (baptistjax.com)
ST-400 is a experimental cell therapy for beta thalassemia , a rare blood disease. (patientworthy.com)
Within just a few weeks of treatment, the patient displayed significant recovery in levels of neutrophils and platelets, two of the most important blood cells that are frequently in low supply in beta thalassemia patients. (patientworthy.com)

Computed tomography scanning of the liver to determine efficacy of iron chelation therapy in thalassemia major. (sickkids.ca)

Which children are at risk for alpha thalassemia? (rochester.edu)

What are the symptoms of alpha thalassemia in a child? (rochester.edu)

There is no effective treatment for alpha thalassemia major. (rochester.edu)

The effects of diuresis and transfusion on pulmonary function in children with thalassemia major. (sickkids.ca)

Dr. Nita, who has devoted her career towards helping and treating patients of thalassemia, explained in detail about the actual causes of thalassemia, what it does to one's body, the treatments that are currently in practice for this disease and the intense pain and inconvenience and patients and their families have to go through. (scit.edu)
Acute Wilson's disease and thalassemia minor: a case report. (uclouvain.be)
The case of a 17-year-old Italian girl with thalassemia minor and fatal acute Wilson's disease together with severe hemolysis is reported. (uclouvain.be)

Thalassemia is more prevalent in regions in which malaria is endemic because the RBC phenotype confers some protection against malaria. (medscape.com)

Both alpha and beta thalassemia contain thalassemia minor and thalassmia major. (prezi.com)
Alpha thalassemia major (also called Hb Bart syndrome). (rochester.edu)
Alpha thalassemia is passed from parents to children. (rochester.edu)
How is alpha thalassemia diagnosed in a child? (rochester.edu)
How is alpha thalassemia treated in a child? (rochester.edu)
What are the complications of alpha thalassemia in a child? (rochester.edu)
Most babies with alpha thalassemia major are stillborn or die soon after birth. (rochester.edu)
How is alpha thalassemia managed in a child? (rochester.edu)
What are your Alpha Thalassemia Symptoms? (medicinenet.com)
How was your alpha thalassemia diagnosed? (medicinenet.com)
Alpha thalassemias occur most often in people from Southeast Asia, the Middle East, China, and in those of African descent. (baptistjax.com)
The most severe form of alpha thalassemia major causes stillbirth (death of the unborn baby during birth or the late stages of pregnancy). (baptistjax.com)
A test called mutational analysis can help detect alpha thalassemia. (baptistjax.com)

Chelation use and iron burden in North American and British thalassemia patients: a report from the Thalassemia Longitudinal Cohort. (sickkids.ca)

Treatments for beta thalassemia will vary based on its type and severity. (nicklauschildrens.org)

Anatomy6

Diseases19

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes16

Disciplines and Occupations1

Information Science1

Geographicals6

Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and deltabeta-thalassemia affects beta- but not gamma-globin gene expression. (1/992)

A new alkali-resistant hemoglobin alpha2J Oxford gammaF2 in a Sicilian baby girl with homozygous beta0 thalassemia. (2/992)

'Common' uncommon anemias. (3/992)

Hormonal changes in thalassaemia major. (4/992)

Birth of healthy children after preimplantation diagnosis of thalassemias. (5/992)

Further evidence of a quantitative deficiency of chain-specific globin mRNA in the thalassemia syndromes. (6/992)

Coexistence of two functioning T-cell repertoires in healthy ex-thalassemics bearing a persistent mixed chimerism years after bone marrow transplantation. (7/992)

Relative numbers of human globin genes assayed with purified alpha and beta complementary human DNA. (8/992)

Thalassemia

beta-Thalassemia

alpha-Thalassemia

Hemoglobin E

Chelation Therapy

Globins

Hemoglobins, Abnormal

Iron Overload

Hemoglobinopathies

Iron Chelating Agents

Hemoglobin A2

alpha-Globins

Fetal Hemoglobin

Blood Transfusion

Deferoxamine

Pyridones

beta-Globins

Anemia, Sickle Cell

Hemoglobin H

Sicily

Hemoglobin J

Iron

Homozygote

Erythrocyte Count

Erythrocytes, Abnormal

Ferritins

Sickle Cell Trait

Heterozygote

Erythrocyte Indices

Hemoglobins

Hemosiderosis

Hemoglobin A

Reticulocytes

delta-Thalassemia

Hemoglobinometry

Erythropoiesis

Splenectomy

Hemoglobin, Sickle

Anemia, Hypochromic

Osmotic Fragility

Erythrocytes

Heterozygote Detection

Hemoglobin C

Hematopoiesis, Extramedullary

Italy

Arabia

delta-Globins

Erythrocyte Aging

Benzoates

Electronics, Medical

Hemoglobin C Disease

Hemoglobin SC Disease

Anemia

Melanesia

Siderophores

Endocrine System Diseases

Hemosiderin

Hemochromatosis

Thailand

Prenatal Diagnosis

Blood Protein Electrophoresis

Erythrocyte Transfusion

Chromosome Deletion

Genes

Heinz Bodies

gamma-Globins

Hemolysis

Cyprus

Erythroid Precursor Cells

Genotype

Erythrocyte Deformability

Mutation

Phenotype

Pedigree

Anemia, Hemolytic

Iron, Dietary

Liver

Gilbert Disease

Base Sequence

Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and deltabeta-thalassemia affects beta- but not gamma-globin gene expression. (1/992)