Tetradecanoylphorbol Acetate
Protein Kinase C
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Acetates
Hematologic Neoplasms
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Neoplasms
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Bone Marrow Cells
Bone Marrow Transplantation
Epidermal Growth Factor
A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
Mitogens
Fibroblast Growth Factors
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Cells, Cultured
Lymph Nodes
Melanocytes
Mammalian pigment cells that produce MELANINS, pigments found mainly in the EPIDERMIS, but also in the eyes and the hair, by a process called melanogenesis. Coloration can be altered by the number of melanocytes or the amount of pigment produced and stored in the organelles called MELANOSOMES. The large non-mammalian melanin-containing cells are called MELANOPHORES.
Neural Crest
The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.
Melanins
Monophenol Monooxygenase
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Coturnix
Keratinocytes
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
Gene Expression Profiling
Neoplasms, Glandular and Epithelial
Carcinoma, Squamous Cell
Oligonucleotide Array Sequence Analysis
Papilloma
Androgens
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
Staurosporine
Phorbol Esters
The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. (1/10860)
Transcription factors of the interferon regulatory factor (IRF) family bind to the type I interferon (IFN)-responsive element (ISRE) and activate transcription from IFN-inducible genes. To identify cofactors that associate with IRF proteins, DNA affinity binding assays were performed with nuclear extracts prepared from tissue culture cells. The results demonstrated that the endogenous IRFs bound to the ISRE are complexed with the histone acetylases, PCAF, GCN5, and p300/CREB binding protein and that histone acetylase activities are accumulated on the IRF-ISRE complexes. By testing recombinant proteins, we show that PCAF directly binds to some but not all members of the IRF family through distinct domains of the two proteins. This interaction was functionally significant, since transfection of PCAF strongly enhanced IRF-1- and IRF-2-dependent promoter activities. Further studies showed that expression of PCAF and other histone acetylases was markedly induced in U937 cells upon phorbol ester treatment, which led to increased recruitment of PCAF to the IRF-ISRE complexes. Coinciding with the induction of histone acetylases, phorbol ester markedly enhanced IFN-alpha-stimulated gene expression in U937 cells. Supporting the role for PCAF in conferring IFN responsiveness, transfection of PCAF into U937 cells led to a large increase in IFN-alpha-inducible promoter activity. These results demonstrate that PCAF is a phorbol ester-inducible coactivator of the IRF proteins which contributes to the establishment of type I IFN responsiveness. (+info)Activation of IkappaB kinase beta by protein kinase C isoforms. (2/10860)
The atypical protein kinase C (PKC) isotypes (lambda/iotaPKC and zetaPKC) have been shown to be critically involved in important cell functions such as proliferation and survival. Previous studies have demonstrated that the atypical PKCs are stimulated by tumor necrosis factor alpha (TNF-alpha) and are required for the activation of NF-kappaB by this cytokine through a mechanism that most probably involves the phosphorylation of IkappaB. The inability of these PKC isotypes to directly phosphorylate IkappaB led to the hypothesis that zetaPKC may use a putative IkappaB kinase to functionally inactivate IkappaB. Recently several groups have molecularly characterized and cloned two IkappaB kinases (IKKalpha and IKKbeta) which phosphorylate the residues in the IkappaB molecule that serve to target it for ubiquitination and degradation. In this study we have addressed the possibility that different PKCs may control NF-kappaB through the activation of the IKKs. We report here that alphaPKC as well as the atypical PKCs bind to the IKKs in vitro and in vivo. In addition, overexpression of zetaPKC positively modulates IKKbeta activity but not that of IKKalpha, whereas the transfection of a zetaPKC dominant negative mutant severely impairs the activation of IKKbeta but not IKKalpha in TNF-alpha-stimulated cells. We also show that cell stimulation with phorbol 12-myristate 13-acetate activates IKKbeta, which is entirely dependent on the activity of alphaPKC but not that of the atypical isoforms. In contrast, the inhibition of alphaPKC does not affect the activation of IKKbeta by TNF-alpha. Interestingly, recombinant active zetaPKC and alphaPKC are able to stimulate in vitro the activity of IKKbeta but not that of IKKalpha. In addition, evidence is presented here that recombinant zetaPKC directly phosphorylates IKKbeta in vitro, involving Ser177 and Ser181. Collectively, these results demonstrate a critical role for the PKC isoforms in the NF-kappaB pathway at the level of IKKbeta activation and IkappaB degradation. (+info)Enhanced adhesion of Pasteurella multocida to cultured turkey peripheral blood monocytes. (3/10860)
Capsular hyaluronic acid (HA) mediates adhesion of serogroup A strains of Pasteurella multocida to elicited turkey air sac macrophages (TASM). In contrast, freshly isolated turkey peripheral blood monocytes (TPBM) do not bind serogroup A strains. Following culture of TPBM for 6 days in chamber slides, adhesion of the bacteria to TPBM increased gradually. Incubation in chamber slides coated with entactin-collagen IV-laminin (ECL) attachment matrix or exposure to phorbol myristate acetate (PMA) further enhanced the adhesion of P. multocida to TPBM. Addition of HA, but not Arg-Gly-Asp peptide, to TPBM culture inhibited bacterial adherence similarly to the inhibition previously reported for TASM. Exposure of TPBM to monoclonal antibody directed against HA-binding cell surface proteoglycan (CD44) decreased binding of P. multocida. Collectively, these findings indicate that P. multocida adhesion to TPBM is mediated by capsular HA and can be increased by culture on ECL attachment matrix or PMA exposure. Additionally, the findings suggest that the capsular mucopolysaccharide of serogroup A strains of P. multocida recognizes an isoform of CD44 expressed on cultured TPBM. (+info)Modulation of basal intracellular calcium by inverse agonists and phorbol myristate acetate in rat-1 fibroblasts stably expressing alpha1d-adrenoceptors. (4/10860)
In rat-1 fibroblasts stably expressing alpha1d-adrenoceptors BMY 7378, phentolamine, chloroethylclonidine and 5-methyl urapidil decreased basal [Ca2+]i. WB 4101 induced a very small effect on this parameter but when added before the other antagonists it blocked their effect. All these agents inhibited the action of norepinephrine. Phorbol myristate acetate also blocked the effect of norepinephrine and decreased basal [Ca2+]i. Staurosporine inhibited these effects of the phorbol ester. Our results suggest that: (1) alpha1d-adrenoceptors exhibit spontaneous ligand-independent activity, (2) BMY 7378, phentolamine, chloroethylclonidine and 5-methyl urapidil act as inverse agonists and (3) protein kinase C activation blocks spontaneous and agonist-stimulated alpha1d-adrenoceptor activity. (+info)Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-tau in bovine endometrial cells. (5/10860)
Oxytocin (OT) is responsible for the episodic release of luteolytic prostaglandin (PG) F2alpha from the uterus in ruminants. The attenuation of OT-stimulated uterine PGF2alpha secretion by interferon-tau (IFN-tau) is essential for prevention of luteolysis during pregnancy in cows. To better understand the mechanisms involved, the effect of recombinant bovine IFN-tau (rbIFN-tau) on OT-induced PG production and cyclooxygenase-2 (COX-2) and PGF synthase (PGFS) expression in cultured endometrial epithelial cells was investigated. Cells were obtained from cows at Days 1-3 of the estrous cycle and cultured to confluence in RPMI medium supplemented with 5% steroid-free fetal calf serum. The cells were then incubated in the presence or absence of either 100 ng/ml OT or OT+100 ng/ml rbIFN-tau for 3, 6, 12, and 24 h. OT significantly increased PGF2alpha and PGE2 secretion at all time points (p < 0.01), while rbIFN-tau inhibited the OT-induced PG production and reduced OT receptor binding in a time-dependent manner. OT increased the steady-state level of COX-2 mRNA, measured by Northern blot, which was maximal at 3 h (9-fold increase) and then decreased with time (p < 0.01). OT also caused an increase in COX-2 protein, which peaked at 12 h (11-fold increase), as measured by Western blot. Addition of rbIFN-tau suppressed the induction of COX-2 mRNA (89%, p < 0.01) and COX-2 protein (50%, p < 0.01) by OT. OT also increased PGFS mRNA, and this stimulation was attenuated by rbIFN-tau (p < 0.01). To ensure that the decrease in COX-2 was not solely due to down-regulation of the OT receptor, cells were stimulated with a phorbol ester (phorbol 12-myristate 13-acetate; PMA) in the presence and absence of rbIFN-tau. The results showed that rbIFN-tau also decreased PMA-stimulated PG production and COX-2 protein. It can be concluded that rbIFN-tau inhibition of OT-stimulated PG production is due to down-regulation of OT receptor, COX-2, and PGFS. (+info)Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase is directly activated by p38 kinase. (6/10860)
Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, along with phospholipase A2, is a key regulator of platelet-activating factor biosynthesis via the remodeling pathway. We have now obtained evidence in human neutrophils indicating that this enzyme is regulated by a specific member of the mitogen-activated protein kinases, namely the p38 kinase. We earlier demonstrated that tumor necrosis factor-alpha (TNF-alpha) as well as N-formyl-methionyl-leucyl-phenylalanine treatment leads to increased phosphorylation and activation of p38 kinase in human neutrophils. Strikingly, in the present study these stimuli increased the catalytic activity of acetyltransferase up to 3-fold, whereas 4-phorbol 12-myristate 13-acetate, which activates the extracellular-regulated kinases (ERKs) but not p38 kinase, had no effect. Furthermore, a selective inhibitor of p38 kinase, SB 203580, was able to abolish the TNF-alpha- and N-formyl-methionyl-leucyl-phenylalanine-induced activation of acetyltransferase. The same effect was not observed in the presence of an inhibitor that blocked ERK activation (PD 98059). Complementing the findings in intact cells, we have shown that recombinant, activated p38 kinase added to microsomes in the presence of Mg2+ and ATP increased acetyltransferase activity to the same degree as in microsomes obtained from TNF-alpha-stimulated cells. No activation of acetyltransferase occurred upon treatment of microsomes with either recombinant, activated ERK-1 or ERK-2. Finally, the increases in acetyltransferase activity induced by TNF-alpha could be ablated by treating the microsomes with alkaline phosphatase. Thus acetyltransferase appears to be a downstream target for p38 kinase but not ERKs. These data from whole cells as well as cell-free systems fit a model wherein stimulus-induced acetyltransferase activation is mediated by a phosphorylation event catalyzed directly by p38 kinase. (+info)Molecular mechanisms of proliferation in endometrial tumour cells. (7/10860)
The human endometrium normally undergoes a cyclic proliferation process followed by differentiation under the influence of ovarian steroids and locally produced growth and differentiation factors. Understanding of the molecular mechanisms involved in controlling these processes is of great interest, since imbalances between proliferation- and differentiation-promoting signals can have pathophysiological consequences ranging from infertility to endometrial hyperplasia and tumour formation. The present work reviews aspects of the role played by oncogenes and ovarian steroid receptors in modulating proliferation of endometrial tumour cells. The expression pattern and possible roles of protein kinase C (PKC) subunits are discussed in the context of response-specificity of endometrial tumour cells to tumour-promoting agents such as 12-O-tetradecanoyl-phorbol acetate (TPA) and possible implications for anti-tumour therapy. (+info)Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation. (8/10860)
The mitogen activated protein (MAP) kinases or extracellular signal-regulated kinases (Erks) are activated in response to Ras expression or exposure to tumor promoters or to growth factors, and have been implicated in AP-1 transactivation in some models. We have shown that tumor promoter induced activation of the transcription factor AP-1 is required for induced neoplastic transformation in the Balb/C JB6 cell model. Jun and Fos family protein levels have been found not to be limiting for AP-1 response. The present study asks whether activation of Erks1 and 2 is required for AP-1 transactivation and transformation of JB6 cells and whether Erks might be targeted for cancer prevention. Expression of either of two different dominant negative kinase inactive Erk2 mutants in transformation sensitive (P+) JB6 cells substantially inhibited the tumor promoter induced activation of Erks1 and 2 and of AP-1 measured by a collagenase-luciferase reporter. Multiple mutant Erk2 expressing clonal lines were also rendered non-responsive to induced neoplastic transformation. These observations, together with our recent finding attributing AP-1 non-responsiveness to Erk deficiency in a clonal line of transformation resistant (P-) cells, argue for a requirement for Erks1 and/or 2 activation in AP-1 transactivation in the mouse JB6 neoplastic progression model, and suggest the utility of Erks as a prevention target. (+info)
Effect of phorbol myristate acetate-induced lung injury on airway blood flow<...
Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3...
Details-Calcnet-TargetNet
Characterization of the inhibition of interleukin 2 mRNA accumulation by 12-O-tetradecanoylphorbol-13-acetate in primary...
Effect of PMA treatment on the expression of cyclins an | Open-i
CAS 116526-84-2 2-(4-NITROPHENOXY)TETRADECANOYL CHLORIDE, 92 - BOC Sciences
Comparison of M-line and other myofibril components during reversible phorbol ester treatment.<...
The Cyclin-dependent Kinase Inhibitor (CDKI) Flavopiridol Disrupts Phorbol 12-Myristate 13-Acetate-induced Differentiation and...
Enhanced vascular reactivity to protein kinase C activators in genetically hypertensive rats - Fingerprint
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Phorbol Ester TPA Modulates Chemoresistance in the Drug Sensitive Breast Cancer Cell Line MCF-7 by Inducing Expression of Drug...
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Identification, characterization and expression analysis of a novel TPA (12-0-Tetradecanoylphorbol-13-Acetate) induced gene. |...
The protein kinase C activator, phorbol ester, elicits disparate functional responses in androgen-sensitive and androgen...
Heparin decreases activator protein-1 binding to DNA in part by posttranslational modification of Jun B. | Circulation Research
Reversal of defective IL-6 production in lipopolysaccharide-tolerant mice by phorbol myristate acetate<...
cytosolic-nuclear tumor promoter binding protein
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Amplifier Denon PMA-800NE, PMA800NEB | Euronics
Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced...
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In-situ Protein Kinase C assay
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Temporal infiltration of leukocyte subsets into mouse skin inflamed with phorbol ester | SpringerLink
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Stimulation of melanogenesis by tetradecanoylphorbol 13-acetate (TPA) in mouse melanocytes and neural crest cells. - The...
Effects of protein kinase C activators on phorbol ester-sensitive and -resistant EL4 thymoma cells. : Carcinogenesis - oi
Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation<...
Phorbol ester tumor promoters and the anti-tumor-promoter dexamethasone share a molecular target: modulation of the...
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling
from inositol phospholipid...
Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced...
Effect of bee venom and its fractions on the release of pro-inflammatory cytokines in PMA-differentiated U937 cells co...
Activity and regulation of calcium-, phospholipid-dependent protein kinase in differentiating chick myogenic cells. | JCB
Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. | PNAS
Differential effects of protein kinase C on the levels of epithelial Na<sup>+</sup> channel subunit...
Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human...
Regulation of fibronectin gene expression by cyclic AMP and phorbol myristate acetate in HT-1080 human fibrosarcoma cells<...
Effects of Polyol Pathway Hyperactivity on Protein Kinase C Activity, Nociceptive Peptide Expression, and Neuronal Structure in...
B lymphocytes are necessary cells in defense replies. B lymphocytes HVCN1S - Small Molecule Inhibitors of Protein Arginine...
Quercetin inhibition of tumor invasion via suppressing PKCδ/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast...
Similar effects of electroporational stress and treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on...
Asian Science Citation Index - Articles written by I Torii
Preliminary study on the Evaluation of Spirulina on TPA-induced Mouse Ear Inflammation-Florina-Maria Andrica, Teodora Daniela...
Preliminary study on the Evaluation of Spirulina on TPA-induced Mouse Ear Inflammation-Florina-Maria Andrica, Teodora Daniela...
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Gentaur Molecular :Assaypro \ tPA, anti human \ 11631-05021
MS100a7a15
TPA (12-O-Tetradecanoylphorbol-13-acetate), a potent PKC activator, induces mS100a7a15 expression. TPA induces mS100a7a15 ...
Calanolide A
TPA (12-O-Tetradecanoylphorbol-13-acetate) is a tumour promoter used in biomedical research. EBV-EA is Epstein-Barr virus early ...
KCNK9
Phorbol 12-myristate 13-acetate is also known as 12-O-tetradecanoylphorbol-13-acetate (TPA). TASK channels are additionally ... and strongly inhibited by phorbol 12-myristate 13-acetate. ...
IFRD1
... a gene induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate". Oncogene. 4 (10): 1263-5. PMID 2797820 ...
Jun dimerization protein
JDP2 regulates 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE)- and cAMP-responsive element (CRE)-dependent ...
Involucrin
... activation by 12-O-tetradecanoylphorbol-13-acetate". The Journal of Investigative Dermatology. 100 (1): 10-5. doi:10.1111/1523- ...
ODC1
Kim YJ, Pan H, Verma AK (July 1994). "Non-AP-1 tumor promoter 12-O-tetradecanoylphorbol-13-acetate-responsive sequences in the ...
Phorbol esters
In particular, 12-O-tetradecanoylphorbol-13-acetate (TPA) is used as a biomedical research tool in models of carcinogenesis. ... "Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action". Nature. 293 (5828): 144-6. ...
Satyavati Motiram Sirsat
"Ultrastructural Analysis of Epidermal Hyperplasia Induced by Multiple 12-0-Tetradecanoyl-Phorbol-13-Acetate (TPA) Treatment of ...
Phorbol 12,13-dibutyrate
As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O-tetradecanoylphorbol-13-acetate. PDBu is ...
7,12-Dimethylbenz(a)anthracene
Tumor promotion can be induced with treatments of 12-O-tetradecanoylphorbol-13-acetate (TPA) in some models of two-stage ...
Mir-22
Expression of miR-22 can be induced by adding 12-O-Tetradecanoylphorbol-13-acetate (TPA) to HL-60 cells (leukaemia cell line). ...
GPRC5A
"Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 ...
Osteopontin
Chang PL, Prince CW (May 1991). "1 alpha,25-Dihydroxyvitamin D3 enhances 12-O-tetradecanoylphorbol-13-acetate- induced ...
AKR1B10
... of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa ...
Ergosterol peroxide
"Inhibitory effects of sterols isolated from Chlorella vulgaris on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and ...
CD30
"A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and ...
Croton (plant)
... such as 12-O-tetradecanoylphorbol-13-acetate. In the Amazon, the red latex from the species C. lechleri, known as sangre de ...
Caffeic acid phenethyl ester
April 1996). "Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor ... and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate". Cancer Res. 48 (21): 5941-6. PMID ...
Lophira alata
... significantly inhibited tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate (TPA, 1.6 nmol). This article ...
Phorbol
The most common and potent phorbol ester is 12-O-tetradecanoylphorbol-13-acetate (TPA), also called phorbol-12-myristate-13- ... Tseng SS, van Duuren BL, Solomon JJ (1977). "Synthesis of 4aα-Phorbol 9-Myristate 9a-Acetate and Related Esters". J. Org. Chem ... pentacyclic triterpene α-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate". ... acetate (PMA), which is used as a biomedical research tool in contexts such as models of carcinogenesis. Phorbol is a natural ...
Bilobol
"Comparison of the effects of bilobol and 12-O-tetradecanoylphorbol-13-acetate on skin, and test of tumor promoting potential of ...
Midkine
... complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast ...
Contact dermatitis
1990). "Comparison of the effects of bilobol and 12-O-tetradecanoylphorbol-13-acetate on skin, and test of tumor promoting ...
AP-1 transcription factor
The AP-1 binding site was identified as the 12-O-Tetradecanoylphorbol-13-acetate (TPA) response element (TRE) with the ...
BTG2
... tetradecanoyl phorbol acetate-inducible sequence 21) protein in mouse. Tis21 had been originally isolated as a sequence induced ...
Stephanie Klemons
CS1 maint: discouraged parameter (link) "Synergistic stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate and capsaicin ...
HL60
Other compounds like 1,25-dihydroxyvitamin D3, 12-O-tetradecanoylphorbol-13-acetate (TPA) and GM-CSF can induce HL-60 to ...
CYR61
... the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), cAMP, vitamin D3, estrogen and tamoxifen, angiotensin II, hypoxia ...
Allixin
... that allixin exerts an anti-promoting activity against skin tumors induced by the chemical 12-O-tetradecanoylphorbol-13-acetate ...
Lamotrigine
Lithium (lithium acetate, lithium carbonate, lithium chloride, lithium citrate, lithium hydroxide, lithium orotate) ...
Domperidone
The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). In some nations, including Australia, domperidone is used off-label, based on uncertain and anecdotal evidence of its usefulness, as a therapy for mothers who are having difficulty breastfeeding.[24][25] In the United States, domperidone is not approved for this or any other use.[26][27] A study called the EMPOWER trial was designed to assess the effectiveness and safety of domperidone in assisting mothers of preterm babies to supply breast milk for their infants.[28] The study randomized 90 mothers of preterm babies to receive either domperidone 10 mg orally three times daily for 28 days (Group A) or placebo 10 mg orally three times daily for 14 days followed by domperidone ...
Dihydropyridine
... (DHP) is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure. ...
Glisoxepide
InChI=1S/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27) ...
Carbamazepine
Lithium (lithium acetate, lithium carbonate, lithium chloride, lithium citrate, lithium hydroxide, lithium orotate) ...
Inward-rectifier potassium channel
A channel that is "inwardly-rectifying" is one that passes current (positive charge) more easily in the inward direction (into the cell) than in the outward direction (out of the cell). It is thought that this current may play an important role in regulating neuronal activity, by helping to stabilize the resting membrane potential of the cell. By convention, inward current (positive charge moving into the cell) is displayed in voltage clamp as a downward deflection, while an outward current (positive charge moving out of the cell) is shown as an upward deflection. At membrane potentials negative to potassium's reversal potential, inwardly rectifying K+ channels support the flow of positively charged K+ ions into the cell, pushing the membrane potential back to the resting potential. This can be seen in figure 1: when the membrane potential is clamped negative to the channel's resting potential (e.g. -60 mV), inward current flows (i.e. positive charge flows into the cell). However, when the ...
Contact dermatitis
1990). "Comparison of the effects of bilobol and 12-O-tetradecanoylphorbol-13-acetate on skin, and test of tumor promoting ...
Phenibut
... also binds to and blocks α2δ subunit-containing VDCCs, similarly to gabapentin and pregabalin, and hence is a gabapentinoid.[9][16] Both (R)-phenibut and (S)-phenibut display this action with similar affinity (Ki = 23 and 39 μM, respectively).[9] Moreover, (R)-phenibut possesses 4-fold greater affinity for this site than for the GABAB receptor (Ki = 92 μM), while (S)-phenibut does not bind significantly to the GABAB receptor (Ki , 1 mM).[9] As such, based on the results of this study, phenibut would appear to have much greater potency in its interactions with α2δ subunit-containing VDCCs than with the GABAB receptor (between 5- to 10-fold).[9] For this reason, the actions of phenibut as a α2δ subunit-containing voltage-gated calcium channel blocker or gabapentinoid may be its true primary mechanism of action, and this may explain the differences between phenibut and its close relative baclofen (which, in contrast, has essentially insignificant activity as a gabapentinoid; Ki = 6 ...
Bepridil
InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3 ...
Valpromide
Lithium (lithium acetate, lithium carbonate, lithium chloride, lithium citrate, lithium hydroxide, lithium orotate) ...
Sodium channel blocker
Class Ib antiarrhythmic agents are sodium channel blockers. They have fast onset and offset kinetics, meaning that they have little or no effect at slower heart rates, and more effects at faster heart rates. Class Ib agents shorten the action potential duration and reduce refractoriness. These agents will decrease Vmax in partially depolarized cells with fast response action potentials. They either do not change the action potential duration, or they may decrease the action potential duration. Class Ib drugs tend to be more specific for voltage gated Na channels than Ia. Lidocaine in particular is highly frequency dependent, in that it has more activity with increasing heart rates. This is because lidocaine selectively blocks Na channels in their open and inactive states and has little binding capability in the resting state. Class Ib agents are indicated for the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation. Class Ib ...
Kavain
... has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels.[1] How this effect is mediated and to what extent this mechanism is involved in the anxiolytic and analgesic effects of kavalactones on the central nervous system is unknown. Kavain's pharmacological activities have not been sufficiently investigated, and neither its effect as a serotonin reuptake inhibitor nor its monoamine (norepinephrine) uptake inhibitions and activation of NMDA receptors have been confirmed. The mechanism behind the psychotropic, sedative, and anxiolytic actions of kavain and related kavalactones is still debated. Direct binding to the benzodiazepine/flumazenil binding site of the GABA-A receptor does not occur with kavain enantiomers.[2] Many studies involved kava extracts from different plant parts and are, therefore, not applicable to kavain itself. In 2016, kavain was shown to bind at the α4β2δ GABAA receptor and ...
Interleukin 17
... psoriatic lesion development upon stimulation with the lesion-causing tumor promoter 12-O-tetradecanoylphorbol-13-acetate.[6] ...
Epstein-Barr virus
EBV in B cells can also be reactivated by treating the cells with sodium butyrate or 12-O-Tetradecanoylphorbol-13-acetate.[ ...
Charybdotoxin
... occludes the pore of calcium-activated voltage-gated shaker K+ channels by binding to one of four independent, overlapping binding sites.[6][7] It binds both to the open and the closed states. In addition, the block is enhanced as the ionic strength is lowered.[8] This block occurs as the Asn 30 on the CTX interacts with the Asp 381 on the K+ channel.[9] The blockade of K+ channels by the charybdotoxin peptide causes neuronal hyperexcitability. Mutations of the Lys31Gln and the Asn30Gln had the effect of lessening the CTX block of the pore on the shaker channel.[9] ...
Gliclazide
... selectively binds to sulfonylurea receptors (SUR-1) on the surface of the pancreatic beta-cells. It was shown to provide cardiovascular protection as it does not bind to sulfonylurea receptors (SUR-2A) in the heart.[10] This binding effectively closes these K+ ion channels. This decreases the efflux of potassium from the cell which leads to the depolarization of the cell. This causes voltage dependent Ca2+ ion channels to open increasing the Ca2+ influx. The calcium can then bind to and activate calmodulin which in turn leads to exocytosis of insulin vesicles leading to insulin release.[citation needed] The mouse model of MODY diabetes suggested that the reduced gliclazide clearance stands behind their therapeutic success in human MODY patients, but Urbanova et al. found that human MODY patients respond differently and that there was no consistent decrease in gliclazide clearance in randomly selected HNF1A-MODY and HNF4A-MODY patients.[11] Its classification has been ambiguous, as ...
Mexiletine
... has several uses including the treatment of abnormal heart rhythms or arrhythmias, chronic pain, and myotonia. In general when treating arrhythmias, mexiletine is reserved for use in dangerous heart rhythm disturbances such as ventricular tachycardia.[2] It is of particular use when treating arrhythmias caused by long QT syndrome.[3] The LQT3 form of long QT syndrome is amenable to treatment with mexiletine as this form is caused by defective sodium channels that continue to release a sustained current rather than fully inactivating, however other forms of long QT syndrome can also be treated with this medication.[3] Mexiletine has been used to treat chronic pain and may also be used to treat muscle stiffness resulting from myotonic dystrophy (Steinert's disease) or nondystrophic myotonias such as myotonia congenita (Thomsen syndrome or Becker syndrome).[4][5] ...
Phenytoin
Abiraterone acetate. *Alestramustine. *Almestrone. *Anabolic steroids (e.g., testosterone and esters, methyltestosterone, ...
Nefopam
... is effective for prevention of shivering during surgery or recovery from surgery.[5][6] Nefopam was significantly more effective than aspirin as an analgesic in one clinical trial,[7] although with a greater incidence of side effects such as sweating, dizziness and nausea, especially at higher doses.[8][9] The estimated relative potency of nefopam to morphine indicates that 20 mg of nefopam HCl is the approximate analgesic equal of 12 mg of morphine with comparable analgesic efficacy to morphine,[10][11][12] or oxycodone,[13] while Nefopam tends to produce fewer side effects, does not produce respiratory depression,[14] and has much less abuse potential, and so is useful either as an alternative to opioids, or as an adjunctive treatment for use alongside opioid(s) or other analgesics.[12][15] Nefopam is also used to treat severe hiccups.[16] ...
Phorbol-12-myristate-13-acetate-induced protein 1
12-O-Tetradecanoylphorbol-13-acetate (Phorbol-12-myristate-13-acetate) GRCh38: Ensembl release 89: ENSG00000141682 - Ensembl, ... Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known ... "Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1". Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, ... "Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly ...
12-O-Tetradecanoylphorbol-13-acetate - Wikipedia
12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate ... Tetradecanoylphorbol+Acetate at the US National Library of Medicine Medical Subject Headings (MeSH) "NCI Dictionary Entry". ... O-tetradecanoylphorbol-13-acetate for patients with relapsed/refractory malignancies". Cancer Chemotherapy and Pharmacology. 57 ... and phorbol 12-myristate 13-acetate (PMA), is a diester of phorbol and a potent tumor promoter often employed in biomedical ...
Definition of 12-O-tetradecanoylphorbol-13-acetate - NCI Dictionary of Cancer Terms - National Cancer Institute
Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1...
12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder
12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with relapsed or refractory. hematologic malignancies or bone marrow ... Patients receive 12-O-tetradecanoylphorbol-13-acetate (TPA) IV over 1 hour on days 1 and 8. followed by 2 weeks of rest. ... Phase I Study of 12-O-tetradecanoylphorbol-13-acetate (TPA) in Patients With Refractory Hematologic Malignancies/Bone Marrow ... Phase I Study of 12-O-tetradecanoylphorbol-13-acetate (TPA) in Patients With Refractory Hematologic Malignancies/Bone Marrow ...
AID 377257 - Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced ornithine decarboxylase activity in mouse ME308 cells -...
Inhibition of the Tumor-promoting Action of 12-O-Tetradecanoylphorbol-13-acetate by Some Oleanane-type Triterpenoid Compounds |...
O-tetradecanoylphorbol 13-acetate.. By in vitro experiment monitoring with 12 - O - tetradecanoylphorbol-13-acetate-induced ... Inhibition of the Tumor-promoting Action of 12-O-Tetradecanoylphorbol-13-acetate by Some Oleanane-type Triterpenoid Compounds. ... Inhibition of the Tumor-promoting Action of 12-O-Tetradecanoylphorbol-13-acetate by Some Oleanane-type Triterpenoid Compounds ... Inhibition of the Tumor-promoting Action of 12-O-Tetradecanoylphorbol-13-acetate by Some Oleanane-type Triterpenoid Compounds ...
AID 131940 - Tested for its antiinflammatory activity in the tetradecanoyl phorbol acetate induced ear edema model (TPA Ear) -...
Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3...
We isolated a group of genes that are rapidly and transiently induced in 3T3 cells by tetradecanoyl phorbol acetate (TPA). ... Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 ... Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 ... Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 ...
Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of...
Induction of early-response genes (tetradecanoyl phorbol acetate [TPA]-induced sequences, or TIS genes; R.W. Lim, B.C. Varnum, ... Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of ... Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of ... Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of ...
Interruption of Nuclear Factor κB Signaling by the Androgen Receptor Facilitates 12-O-Tetradecanoylphorbolacetate-Induced...
2 The abbreviations used are: AR, androgen receptor; PKC, protein kinase C; TPA, 12-O-tetradecanoylphorbol acetate; NFκB, ... 12-O-tetradecanoylphorbolacetate (TPA) influences proliferation, differentiation, and apoptosis in a variety of cells including ... Interruption of Nuclear Factor κB Signaling by the Androgen Receptor Facilitates 12-O-Tetradecanoylphorbolacetate-Induced ... Interruption of Nuclear Factor κB Signaling by the Androgen Receptor Facilitates 12-O-Tetradecanoylphorbolacetate-Induced ...
Effects of the tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate on the wasp Bracon
hebetor.
Effects of the tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate on the wasp Bracon hebetor.. код для вставки. код для ... Louis, MO). 20-[3H](N)-12-0-tetradecanoyl-phorbol-13-acetate with a specific activity of 250 pCilmmo1 was obtained from New ... Key words: anti-vitellogenic benzo(a)pyrene, braconid, habrobracon, TPA INTRODUCTION 12-0-Tetradecanoyl-phorbol-13-acetate has ... 12-O-Tetradecanoyl-phorbol-13acetate. Acknowledgments: The work presented here was supported by grant no. ES-07046 from the ...
Changes in spermine levels are involved in the effects of phorbol ester (12-O-tetradecanoylphorbol-13-acetate) and dibutyryl...
The effects of tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), cAMP analogue dibutyryl cAMP (DB) and histamine were ... Changes in spermine levels are involved in the effects of phorbol ester (12-O-tetradecanoylphorbol-13-acetate) and dibutyryl ... Changes in spermine levels are involved in the effects of phorbol ester (12-O-tetradecanoylphorbol-13-acetate) and dibutyryl ... The effects of tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), cAMP analogue dibutyryl cAMP (DB) and histamine were ...
Get PDF - Induction of chromosomal alterations in primary mouse keratinocyte cultures by 12 o tetradecanoylphorbol 13 acetate...
Induction of chromosomal alterations in primary mouse keratinocyte cultures by 12 o tetradecanoylphorbol 13 acetate but not 12 ... o retinoylphorbol 13 acetate and inhibition of the clastogenic effects by 4 8 11 14 eicosatetraynoic acid and antipain ... tetradecanoylphorbol 13 acetate use of 12 o tetradecanoylphorbol 13 acetate sensitive and 12 o tetradecanoylphorbol 13 acetate ... tetradecanoylphorbol-13-acetate in vivo. Carcinogenesis 8(1): 191-192, 1987. Inhibition of 12-O-tetradecanoylphorbol-13-acetate ...
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate blocks differentiation of HT-29 human colon cancer cells | Journal of...
We have studied the effects of the tumor promoter 12-O-tetradecanoylphorbol-13- acetate (TPA) in the differentiation phenotype ... The tumor promoter 12-O-tetradecanoylphorbol-13-acetate blocks differentiation of HT-29 human colon cancer cells ... The tumor promoter 12-O-tetradecanoylphorbol-13-acetate blocks differentiation of HT-29 human colon cancer cells ... The tumor promoter 12-O-tetradecanoylphorbol-13-acetate blocks differentiation of HT-29 human colon cancer cells ...
Enhancement of human papillomavirus type 18 gene expression in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate, 3 beta,5...
A tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), was found to increase the level of HPV18 transcripts in an HPV18- ... A tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), was found to increase the level of HPV18 transcripts in an HPV18- ... Enhancement of human papillomavirus type 18 gene expression in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate, 3 beta,5 ... Enhancement of human papillomavirus type 18 gene expression in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate, 3 beta,5 ...
Characterization of the inhibition of interleukin 2 mRNA accumulation by 12-O-tetradecanoylphorbol-13-acetate in primary...
N2 - We found previously that bovine lymph node cells (LNC) incubated with 12- O-tetradecanoylphorbol-13-acetate (TPA) for 18 h ... AB - We found previously that bovine lymph node cells (LNC) incubated with 12- O-tetradecanoylphorbol-13-acetate (TPA) for 18 h ... We found previously that bovine lymph node cells (LNC) incubated with 12- O-tetradecanoylphorbol-13-acetate (TPA) for 18 h ... abstract = "We found previously that bovine lymph node cells (LNC) incubated with 12- O-tetradecanoylphorbol-13-acetate (TPA) ...
Ultrastructural studies on cell fusion induced by Epstein-Barr virus or N-butyrate and 12-O-tetradecanoylphorbol-13-acetate....
Identification, characterization and expression analysis of a novel TPA (12-0-Tetradecanoylphorbol-13-Acetate) induced gene. |...
Identification, characterization and expression analysis of a novel TPA (12-0-Tetradecanoylphorbol-13-Acetate) induced gene. ... we have identified and cloned a novel gene that was induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD18 pancreatic ... CHAN CHUNG YIP (2007-02-07). Identification, characterization and expression analysis of a novel TPA (12-0-Tetradecanoylphorbol ... Acetate) induced gene.. [email protected] Repository.. Abstract: Using oligonucleotide microarray, ...
Proteomics-based identification of proteins with altered expression induced by 12-O-tetradecanoylphorbol 13-acetate in...
keywords = "12-O-tetradecanoyl-phorbol-13-acetate, Apoptosis, Nasopharyngeal carcinoma, Proteomics",. author = "Peizhou Jiang ... T1 - Proteomics-based identification of proteins with altered expression induced by 12-O-tetradecanoylphorbol 13-acetate in ... Etiology studies indicate that chemical carcinogen promoters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), are important ... title = "Proteomics-based identification of proteins with altered expression induced by 12-O-tetradecanoylphorbol 13-acetate in ...
Post-transcriptional destabilization of estrogen receptor mRNA in MCF-7 cells by 12-O-Tetradecanoylphorbol-13-acetate<...
The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the regulation of the estrogen receptor (ER) was investigated in ... Post-transcriptional destabilization of estrogen receptor mRNA in MCF-7 cells by 12-O-Tetradecanoylphorbol-13-acetate. Journal ... N2 - The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the regulation of the estrogen receptor (ER) was investigated ... AB - The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the regulation of the estrogen receptor (ER) was investigated ...
Tetradecanoylphorbol-13-acetate (TPA) significantly increases AAV2/5 transduction of human neuronal cells in vitro - Nuffield...
Furthermore, we explore the mechanism whereby exposure to retinoic acid (RA) and the phorbol ester 12-O-Tetradecanoylphorbol-13 ... acetate (TPA) can induce this cell line to differentiate into a stable population of human neurons, with significantly ... Tetradecanoylphorbol-13-acetate (TPA) significantly increases AAV2/5 transduction of human neuronal cells in vitro ... Tetradecanoylphorbol-13-acetate (TPA) significantly increases AAV2/5 transduction of human neuronal cells in vitro ...
Tetradecanoylphorbol Acetate | The Chopra Library
We first determined the effect of topical application of GUG to mice against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ... We first determined the effect of topical application of GUG to mice against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ... We first determined the effect of topical application of GUG to mice against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ... was found to significantly suppress the invasion of cancer cells stimulated by the 12-O-tetradecanoyl-phorbol-13-acetate (TPA). ...
DGIdb - TETRADECANOYL PHORBOL ACETATE Drug Record
Stimulation of melanogenesis by tetradecanoylphorbol 13-acetate (TPA) in mouse melanocytes and neural crest cells. - The...
12-tetradecanoylphorbol 13-acetate (TPA) induces neural crest cell differentiation into melanocytes, and stimulates ... Stimulation of melanogenesis by tetradecanoylphorbol 13-acetate (TPA) in mouse melanocytes and neural crest cells. ... In vitro studies have shown that the phorbol ester, 12-tetradecanoylphorbol 13-acetate (TPA) induces neural crest cell ... Stimulation of melanogenesis by tetradecanoylphorbol 13-acetate (TPA) in mouse melanocytes and neural crest cells. ...
Identification of novel tumour-associated genes differentially expressed in the process of squamous cell cancer development |...
Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in...
The protein kinase C activator, phorbol ester, elicits disparate functional responses in androgen-sensitive and androgen...
Tetradecanoyl phorbol12
- 12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate (PMA), is a diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). (wikipedia.org)
- Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 variants can occur through protein kinase C-dependent and -independent pathways. (asm.org)
- We isolated a group of genes that are rapidly and transiently induced in 3T3 cells by tetradecanoyl phorbol acetate (TPA). (asm.org)
- Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of primary-response TIS genes in both proliferating and terminally differentiated myeloid cells. (asm.org)
- Effects of the tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate on the wasp Bracon hebetor. (docme.ru)
- Key words: anti-vitellogenic benzo(a)pyrene, braconid, habrobracon, TPA INTRODUCTION 12-0-Tetradecanoyl-phorbol-13-acetate has been widely studied in recent years because of its efficacy and potency as a tumor promotor in two-stage carcinogenesis studies with mice. (docme.ru)
- 20-[3H](N)-12-0-tetradecanoyl-phorbol-13-acetate with a specific activity of 250 pCilmmo1 was obtained from New England Nuclear (Boston, MA). (docme.ru)
- The protein kinase C (PKC) activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) activated cell death in androgen-sensitive LNCaP cells but not in androgen-independent DU-145 or PC-3 cells, whose growth was significantly decreased by PKC inhibitors staurosporine and H7. (nih.gov)
- In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA). (biomedsearch.com)
- Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity. (cranberryinstitute.org)
- Here, using dimethylbenzanthracene (DMBA) plus 12-o-tetradecanoyl phorbol-13-acetate (TPA) treatment developing sebaceous neoplasms (SNs) were identified with H&E and Oil red O staining. (medsci.org)
- Previous studies also demonstrated that 12-O-tetradecanoyl-phorbol-13-acetate (TPA) can recruit HFSCs to maintain skin homeostasis and contribute to papilloma, squamous cell carcinoma and basal cell carcinoma [ 3 , 6 , 7 ]. (medsci.org)
Phorbol ester2
- In vitro studies have shown that the phorbol ester, 12-tetradecanoylphorbol 13-acetate (TPA) induces neural crest cell differentiation into melanocytes, and stimulates proliferation and differentiation of normal melanocytes. (ox.ac.uk)
- Arkhammar, P, Nilsson, T & Berggren, PO 1986, ' Stimulation of insulin release by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in the clonal cell line RINm5F despite a lowering of the free cytoplasmic Ca 2+ concentration ', BBA - Molecular Cell Research , vol. 887, no. 2, pp. 236-241. (elsevier.com)
Tumor cells1
- 12-O-tetradecanoylphorbol-13-acetate affects many cell actions and may cause tumor cells to die. (cancer.gov)
Activator1
- TPA (12-O-Tetradecanoylphorbol-13-acetate), a potent PKC activator, induces mS100a7a15 expression. (wikipedia.org)
Induce1
- 12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce differentiation and/or apoptosis in multiple cell lines and primary cells. (elsevier.com)
Murine skin1
- Recent studies have shown that topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to murine skin results in increased expression of the highly inflammatory cytokine interleukin (IL)-1 alpha in the epidermis. (nih.gov)
Chemically induced1
- Treating animals with 3-Methylcholantrene (3MCA) and 7,12-Dimethylbenz(a) anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA), two potent carcinogens, confirmed Spalax high resistance to chemically induced cancers. (nih.gov)
Potent1
- 12-O-Tetradecanoylphorbol-13-acetate (TPA), a component of croton oil, is a potent mouse skin tumor promoter [ 1 , 2 ]. (hindawi.com)
Inhibition3
- Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein. (nih.gov)
- Garlisi, CG & Mastro, AM 1992, ' Characterization of the inhibition of interleukin 2 mRNA accumulation by 12-O-tetradecanoylphorbol-13-acetate in primary lymphocytes ', Lymphokine and Cytokine Research , vol. 11, no. 1, pp. 1-8. (elsevier.com)
- Inhibition of 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory Skin Edema and Ornithine Decarboxylase Activity by Theaflavin-3,3? (encognitive.com)
Refractory1
- Determine the maximum tolerated dose and dose limiting toxicity of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with relapsed or refractory hematologic malignancies or bone marrow disorders. (knowcancer.com)
Cells12
- We have studied the effects of the tumor promoter 12-O-tetradecanoylphorbol-13- acetate (TPA) in the differentiation phenotype of mucus-secreting (HT-29 M6) and absorptive (HT-29 M3) cells. (biologists.org)
- Enhancement of human papillomavirus type 18 gene expression in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate, 3 beta,5 alpha-dihydroxycholestan-6-one, and cholesterol. (semanticscholar.org)
- We found previously that bovine lymph node cells (LNC) incubated with 12- O-tetradecanoylphorbol-13-acetate (TPA) for 18 h proliferate only to a limited degree on subsequent stimulation with concanavalin A (Con A), or with the comitogenic combination of Con A plus TPA. (elsevier.com)
- Using oligonucleotide microarray, we have identified and cloned a novel gene that was induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD18 pancreatic cancer cells. (nus.edu.sg)
- Stimulation of melanogenesis by tetradecanoylphorbol 13-acetate (TPA) in mouse melanocytes and neural crest cells. (ox.ac.uk)
- Previous results have established that 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters can alter the properties of the epidermal growth factor (EGF) receptor through activation of protein kinase C. In order to determine whether other, non-TPA-type tumor promoters might similarly influence growth-mediating receptors, we investigated the effect of palytoxin on EGF binding in Swiss 3T3 fibroblasts and human epidermal carcinoma (A431) cells. (umn.edu)
- This experiment focused on the expressional pattern of keratin 10 (K10 normal differentiation marker), and keratin 8 & 13 (K8 & K13 pathologic differentiation marker) together with their cellular localization after treating HaCaT cells with 12-Otetradecanoylphorbol 13-acetate (TPA). (bvsalud.org)
- To gain insight on the role of AP-1 in transcriptional regulation of vimentin gene during differentiation of HL-60 cells by 12-0-tetradecanoylphorbol-13-acetate (TPA), the levels of vimentin mRNA and AP-1 have been investigated with Northern blot hybridization and DNA mobility shift assay . (bvsalud.org)
- The method has been utilized to examine the stimulation of phosphatidylcholine breakdown in quiescent Swiss 3T3 cells in response to bombesin and 12-O-tetradecanoylphorbol 13-acetate (TPA). (biochemj.org)
- We further investigated the preventive effect of DSW on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced invasive/metastatic tumor features in non-invasive MCF-7 cells. (spandidos-publications.com)
- Basal and epidermal growth factor-induced ERK1/2 phosphorylation was inhibited in several cell lines as well as 12- O -tetradecanoylphorbol-13-acetate-induced ERK1/2 phosphorylation in isolated peripheral blood mononuclear cells. (aacrjournals.org)
- Herein we demonstrate that vanillin reduced 12- O -tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 gelatinolytic activity and suppressed cell invasion through the down-regulation of MMP-9 gene transcription in HepG2 cells. (aspetjournals.org)
Anthracene3
- Here, treatment of the skin with the carcinogen 7,12-dimethylbenz-[ α ]-anthracene (DMBA) and the tumour promoter 12- O -tetradecanoylphorbol-13-acetate (TPA) results in the formation of benign papillomas (PAPs) and malignant tumours (SCCs). (nature.com)
- In the present study, we found that the topical application of xanthorrhizol before 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment significantly inhibits TPA-induced mouse ear edema and TPA-induced tumor promotion in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated ICR mouse skin. (elsevier.com)
- Carcinogenesis was initiated with 7,12-dimethylbenz( a )anthracene and promoted with 12- O -tetradecanoylphorbol-13-acetate (TPA). (aacrjournals.org)
Stimulate1
- 12-O-tetradecanoylphorbol-13-acetate TPA can stimulate acute and chronic inflammation and tumor promotion in skin. (duhnnae.com)
Epidermal1
- Treatment with anti-IL-12/23p40 or anti-IL-23p19 Abs greatly inhibited 12- O -tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia in the ears of K5.Stat3C mice, whereas the inhibitory effect of an anti-IL-17A Ab was relatively less prominent. (jimmunol.org)
Gene2
- Identification, characterization and expression analysis of a novel TPA (12-0-Tetradecanoylphorbol-13-Acetate) induced gene. (nus.edu.sg)
- Effects of electroporation on vimentin gene expression were compared at the cellular and chromatin level to those caused by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). (mpg.de)
Mice6
- We first determined the effect of topical application of GUG to mice against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced conventional markers and other novel markers of skin tumor promotion. (isharonline.org)
- The papilloma response in mice, receiving pretreatments with 2 μgof 12-O-tetradecanoylphorbol-13-acetate (TPA) either 3 days, 1, 2, 3 or 5 weeks before initiation, was similar to that seen when TPA was given after initiation during stage I of promotion followed by stage II of promotion with mezerein (4-5 papillomas per mouse in allgroups). (uthscsa.edu)
- Crossing IL-17A-deficient mice with K5.Stat3C mice resulted in partial attenuation of 12- O -tetradecanoylphorbol-13-acetate-induced lesions, which were further attenuated by anti-IL-12/23p40 Ab treatment. (jimmunol.org)
- For example, K5.Stat3C transgenic mice, in which Stat3 is constitutively expressed in keratinocytes, developed psoriasiform lesions following wounding stimuli or topical treatment with the tumor promoter 12- O -tetradecanoylphorbol-13-acetate (TPA). (jimmunol.org)
- Outbred CD-1 and outbred Sencar mice received a single topical application of the hydrocarbons followed by twice weekly applications of the tumor promoter 12-O-tetradecanoylphorbol 13-acetate for 16-26 weeks. (curehunter.com)
- These compounds elicited significant in vivo anti-allergic and anti-inflammatory effects, suppressing an immunoglobulin E (IgE)-induced passive cutaneous anaphylactic reaction in mice and a 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory mouse ear edema, respectively. (spandidos-publications.com)
Promoters1
- Etiology studies indicate that chemical carcinogen promoters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), are important factors causing NPC development. (elsevier.com)
Lymphocytes3
- The artificial in vitro activation of CD4+ T lymphocytes by a combination of 12-O-tetradecanoylphorbol-13-acetate and ionomycin, the so-called T/I model, led to an inducible production of cytokines, such as interferon-γ, tumor necrosis factor-α, and interleukin-2. (elsevier.com)
- 12-O-Tetradecanoylphorbo-13-acetate (TPA) modulates DNA synthesis in bovine lymph node lymphocytes in culture. (elsevier.com)
- Mastro, AM & Pepin, KG 1980, ' Suppression of Lectin-Stimulated DNA Synthesis in Bovine Lymphocytes by the Tumor Promoter 12-O-Tetradecanoylphorbol-13-acetate ', Cancer Research , vol. 40, no. 9, pp. 3307-3312. (elsevier.com)
Protein1
- Maximal expression of this phenotype required 72 h preactivation with phorbol myristate acetate and expression was abolished using the protein kinase C inhibitor staurosporine. (biomedsearch.com)
Mouse2
- Apigenin is a nonmutagenic bioflavonoid that has been shown to be an inhibitor of mouse skin carcinogenesis induced by the two-stage regimen of initiation and promotion with dimethylbenzanthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA). (nih.gov)
- The painting of mouse dorsal skin with 1 2-0-tetradecanoylphorbol-l3-acetate (TPA) (0.2-2.5 nrTiol/mouse) induced a dose-related increase in vascular permeability, which was determined by pontamine sky blue exudation mto the skin 5 hr after the TPA treatment. (elsevier.com)
Vitro1
- Since glycyrrhetinic acid was proved to suppress tumor promoter effects, several oleanane-type triterpenes which were chemically derived from oleanolic acid and hederagenin were tested in vitro and in vivo against the action of tumor promoter, 12- O -tetradecanoylphorbol 13-acetate. (aacrjournals.org)
ABSTRACT1
- abstract = "The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the regulation of the estrogen receptor (ER) was investigated in this study. (elsevier.com)
Effects2
- The effects of tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), cAMP analogue dibutyryl cAMP (DB) and histamine were studied on arginine decarboxylase activity, polyamine content and growth rate of Trypanosoma cruzi, RA strain epimastigotes. (brillonline.com)
- The effects of 12-O-tetradecanoylphorbol 13-acetate (TPA) on the handling of Ca 2+ and insulin release were investigated in the clonal insulin-producing cell line RINm5F. (elsevier.com)
Cell3
- A tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), was found to increase the level of HPV18 transcripts in an HPV18-harboring cervical cancer cell line, HeLa. (semanticscholar.org)
- Ultrastructural studies on cell fusion induced by Epstein-Barr virus or N-butyrate and 12-O-tetradecanoylphorbol-13-acetate. (uni-regensburg.de)
- 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs. (lclabs.com)
Patients2
- Patients receive 12-O-tetradecanoylphorbol-13-acetate (TPA) IV over 1 hour on days 1 and 8 followed by 2 weeks of rest. (knowcancer.com)
- Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity. (lclabs.com)