Tetracycline. Medical search

A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.

Closely congeneric derivatives of the polycyclic naphthacenecarboxamide. (Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1117)

Nonsusceptibility of bacteria to the action of TETRACYCLINE which inhibits aminoacyl-tRNA binding to the 30S ribosomal subunit during protein synthesis.

A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.

Substances that reduce the growth or reproduction of BACTERIA.

A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.

A synthetic tetracycline derivative with similar antimicrobial activity.

A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.

The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).

A TETRACYCLINE with a 7-chloro substitution.

A TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than TETRACYCLINE, it maintains effective blood levels for longer periods of time.

A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.

A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.

Deoxyribonucleic acid that makes up the genetic material of bacteria.

The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.

An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.

Membrane transporters that co-transport two or more dissimilar molecules in the opposite direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.

A broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.

Proteins found in any species of bacterium.

The functional hereditary units of BACTERIA.

A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.

Nonsusceptibility of an organism to the action of penicillins.

A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.

Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.

A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)

A pyrrolidinylmethyl TETRACYCLINE.

A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).

An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.

A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)

A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.

Vertical transmission of hereditary characters by DNA from cytoplasmic organelles such as MITOCHONDRIA; CHLOROPLASTS; and PLASTIDS, or from PLASMIDS or viral episomal DNA.

Nonsusceptibility of bacteria to the action of CHLORAMPHENICOL, a potent inhibitor of protein synthesis in the 50S ribosomal subunit where amino acids are added to nascent bacterial polypeptides.

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A genus of gram-negative, nonmotile bacteria which are common parasitic inhabitants of the urogenital tracts of humans, cattle, dogs, and monkeys.

Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.

A species of gram-positive, coccoid bacteria commonly isolated from clinical specimens and the human intestinal tract. Most strains are nonhemolytic.

Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.

A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.

Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.

Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.

Microscopy in which the image is formed by ultraviolet radiation and is displayed and recorded by means of photographic film.

Drugs and their metabolites which are found in the edible tissues and milk of animals after their medication with specific drugs. This term can also apply to drugs found in adipose tissue of humans after drug treatment.

Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.

A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.

Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.

A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.

The heritable modification of the properties of a competent bacterium by naked DNA from another source. The uptake of naked DNA is a naturally occuring phenomenon in some bacteria. It is often used as a GENE TRANSFER TECHNIQUE.

A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.

An actinomycete from which the antibiotic CHLORTETRACYCLINE is obtained.

An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. It is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. Food poisoning is the most common clinical manifestation. Organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility.

A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that ferments sugar without gas production. Its organisms are intestinal pathogens of man and other primates and cause bacillary dysentery (DYSENTERY, BACILLARY).

A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.

Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.

A broad-spectrum antimicrobial carboxyfluoroquinoline.

A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)

Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.

A method where a culturing surface inoculated with microbe is exposed to small disks containing known amounts of a chemical agent resulting in a zone of inhibition (usually in millimeters) of growth of the microbe corresponding to the susceptibility of the strain to the agent.

A genus of bacteria found in the reproductive organs, intestinal tract, and oral cavity of animals and man. Some species are pathogenic.

A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).

DNA elements that include the component genes and insertion site for a site-specific recombination system that enables them to capture mobile gene cassettes.

Simultaneous resistance to several structurally and functionally distinct drugs.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Inflammation involving the URETHRA. Similar to CYSTITIS, clinical symptoms range from vague discomfort to painful urination (DYSURIA), urethral discharge, or both.

A technique of bacterial typing which differentiates between bacteria or strains of bacteria by their susceptibility to one or more bacteriophages.

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (1/2398)

A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to the drug or a metabolic aberation of the host permitting the accumulation of hepatotoxic metabolites. The syndromes of hepatic disease produced by drugs have been classified hepatocellular, hepatocanalicular, mixed and canalicular. Measurement of serum enzyme activities has provided a powerful tool for studies of hepatotoxicity. Their measurement requires awareness of relative specificity, knowledge of the mechanisms involved, and knowledge of the relationship between known hepatotoxic states and elevated enzyme activities. (+info)

Assessment of hepatotoxic potential. (2/2398)

Philosophic concepts and pragmatic approaches toward improved understanding of the effect of drugs in the hepatocyte are reviewed. No set pattern of studies is advocated but rather observations are encouraged within the framework of studies that provide for varied exposure of the hepatocyte. Clinical usage should be imitated to provide earliest possible indications of toxicity in man. The need for definitive characterization through utilization of appropriate methodology derived from cross-fertilization of related disciplines is stressed. Both minimal and maximal dose effects should be established. Selected use of electron microscopy has become essential for characterizing responses of the liver to injury. The advantages of the toluidine blue-stained Epon "thick" sections are emphasized. Such observations are used to implement the utility of serial biopsies from the beagle dog prior to and during long-term study of potential hepatic injury. Examples of the critical effects of drug concentration within the hepatocyte are presented. (+info)

Endemic tropical sprue in Rhodesia. (3/2398)

The existence of tropical sprue in Africa is controversial. In this paper we present 31 cases seen in Rhodesia over a 15 month period. They have the clinical features, small intestinal morphology, malabsorption pattern, and treatment response of tropical sprue. Other causes of malabsorption, and primary malnutrition, have been excluded. The severity of the clinical state and intestinal malabsorption distinguish these patients from those we have described with tropical enteropathy. The previous work on tropical sprue in Africa is reviewed and it is apparent that, when it has been adequately looked for, it has been found. It is clear that the question of tropical sprue in Africa must be re-examined and that it existence may have hitherto been concealed by the assumption that primary malnutrition is responsible for the high prevalence of deficiency states. (+info)

In vivo chaperone activity of heat shock protein 70 and thermotolerance. (4/2398)

Heat shock protein 70 (Hsp70) is thought to play a critical role in the thermotolerance of mammalian cells, presumably due to its chaperone activity. We examined the chaperone activity and cellular heat resistance of a clonal cell line in which overexpression of Hsp70 was transiently induced by means of the tetracycline-regulated gene expression system. This single-cell-line approach circumvents problems associated with clonal variation and indirect effects resulting from constitutive overexpression of Hsp70. The in vivo chaperone function of Hsp70 was quantitatively investigated by using firefly luciferase as a reporter protein. Chaperone activity was found to strictly correlate to the level of Hsp70 expression. In addition, we observed an Hsp70 concentration dependent increase in the cellular heat resistance. In order to study the contribution of the Hsp70 chaperone activity, heat resistance of cells that expressed tetracycline-regulated Hsp70 was compared to thermotolerant cells expressing the same level of Hsp70 plus all of the other heat shock proteins. Overexpression of Hsp70 alone was sufficient to induce a similar recovery of cytoplasmic luciferase activity, as does expression of all Hsps in thermotolerant cells. However, when the luciferase reporter protein was directed to the nucleus, expression of Hsp70 alone was not sufficient to yield the level of recovery observed in thermotolerant cells. In addition, cells expressing the same level of Hsp70 found in heat-induced thermotolerant cells containing additional Hsps showed increased resistance to thermal killing but were more sensitive than thermotolerant cells. These results suggest that the inducible form of Hsp70 contributes to the stress-tolerant state by increasing the chaperone activity in the cytoplasm. However, its expression alone is apparently insufficient for protection of other subcellular compartments to yield clonal heat resistance to the level observed in thermotolerant cells. (+info)

Inducible long-term gene expression in brain with adeno-associated virus gene transfer. (5/2398)

Recombinant adeno-associated virus (rAAV) vectors hold promise for treating a number of neurological disorders due to the ability to deliver long-term gene expression without toxicity or immune response. Critical to these endeavors will be controlled expression of the therapeutic gene in target cells. We have constructed and tested a dual cassette rAAV vector carrying a reporter gene under the control of the tetracycline-responsive system and the tetracycline transactivator. Transduction in vitro resulted in stable expression from the vector that can be suppressed 20-fold by tetracycline treatment. In vivo experiments, carried out to 6 weeks, demonstrated that vector-transduced expression is sustained until doxycycline administration upon which reporter gene expression is reduced. Moreover, the suppression of vector-driven expression can be reversed by removal of the drug. These studies demonstrate long-term regulated gene expression from rAAV vectors. This system will provide a valuable approach for controlling vector gene expression both in vitro and in vivo. (+info)

Transcriptional regulation and induction of apoptosis: implications for the use of monomeric p53 variants in gene therapy. (6/2398)

The p53 tumour suppressor protein is a transcriptional activator, which can induce cell cycle arrest and apoptosis. p53 Gene mutations occur in more than 50% of all human tumours. Reintroduction of wild-type p53 but also of oligomerisation-independent p53 variants into tumour cells by gene transfer methods has been considered. We have investigated the biological properties of two carboxy-terminal deletion mutants of p53, p53 delta 300 (comprising amino acids 1-300) and p53 delta 326 (amino acids 1-326), to evaluate their potential deployment in gene therapy. Transactivation was measured in transiently transfected HeLa and SKBR3 cells. Both monomeric variants showed reduced activities compared with wild-type p53. Individual promoters were differently affected. In contrast to wild-type p53, monomeric variants were not able to induce apoptosis. We also provided wild-type p53 and p53 delta 326 with tetracycline-regulated promoters and stably introduced these constructs into Saos2 and SKBR3 cells. Upon induction, wild-type p53 expressing cells, but not p53 delta 326 expressing cells underwent apoptosis. Consistently, only wild-type p53 expressing cells accumulated p21/waf1/cip1 mRNA and protein and showed increased bax, Gadd45 and mdm2 mRNA. Neither wild-type p53 nor p53 delta 326 repressed the transcription of the IGF-1R gene in these cell lines. We conclude that the transactivation potential of monomeric, carboxy-terminally truncated p53 is not sufficient to cause induction of the endogenous target genes which trigger apoptosis. (+info)

The stability and fate of a spliced intron from vertebrate cells. (7/2398)

Introns constitute most of the length of typical pre-mRNAs in vertebrate cells. Thus, the turnover rate of introns may significantly influence the availability of ribonucleotides and splicing factors for further rounds of transcription and RNA splicing, respectively. Given the importance of intron turnover, it is surprising that there have been no reports on the half-life of introns from higher eukaryotic cells. Here, we determined the stability of IVS1Cbeta1, the first intron from the constant region of the mouse T-cell receptor-beta, (TCR-beta) gene. Using a tetracycline (tet)-regulated promoter, we demonstrate that spliced IVS1Cbeta1 and its pre-mRNA had half-lives of 6.0+/-1.4 min and 3.7+/-1.0 min, respectively. We also examined the half-lives of these transcripts by using actinomycin D (Act.D). Act.D significantly stabilized IVS1Cbeta1 and its pre-mRNA, suggesting that Act.D not only blocks transcription but exerts rapid and direct posttranscriptional effects in the nucleus. We observed that in vivo spliced IVS1Cbeta1 accumulated predominantly as lariat molecules that use a consensus branchpoint nucleotide. The accumulation of IVS1Cbeta1 as a lariat did not result from an intrinsic inability to be debranched, as it could be debranched in vitro, albeit somewhat less efficiently than an adenovirus intron. Subcellular-fractionation and sucrose-gradient analyses showed that most spliced IVS1Cbeta1 lariats cofractionated with pre-mRNA, but not always with mRNA in the nucleus. Some IVS1Cbeta1 also appeared to be selectively exported to the cytoplasm, whereas TCR-beta pre-mRNA remained in the nucleus. This study constitutes the first detailed analysis of the stability and fate of a spliced nuclear intron in vivo. (+info)

Functional importance and local environments of the cysteines in the tetracycline resistance protein encoded by plasmid pBR322. (8/2398)

The properties of the cysteines in the pBR322-encoded tetracycline resistance protein have been examined. Cysteines are important but not essential for tetracycline transport activity. None of the cysteines reacted with biotin maleimide, suggesting that they are shielded from the aqueous phase or reside in a negatively charged local environment. (+info)

There are several types of acne, including:

1. Comedonal acne: characterized by blackheads and whiteheads.
2. Inflammatory acne: characterized by papules, pustules, and nodules.
3. Cystic acne: characterized by large, painful cysts that can cause scarring.
4. Acne rosacea: a type of acne that occurs in adults, characterized by redness, flushing, and telangiectasias (small blood vessels).

There are several treatment options for acne vulgaris, including:

1. Topical treatments: such as benzoyl peroxide, salicylic acid, and sulfur.
2. Oral antibiotics: such as doxycycline and minocycline.
3. Retinoids: derived from vitamin A, used to unclog pores and reduce inflammation.
4. Hormonal therapies: such as birth control pills, used to regulate hormones that can contribute to acne.
5. Isotretinoin: a powerful oral medication used for severe cases of cystic acne that have not responded to other treatments.
6. Laser and light therapy: such as blue light therapy and photodynamic therapy, used to reduce inflammation and kill bacteria.
7. Lifestyle modifications: such as using non-comedogenic products, wearing sunscreen, and avoiding picking or popping pimples.

It is important to note that acne can be a persistent condition, and it may take time and experimentation to find the right treatment approach. It's best to consult with a dermatologist for personalized advice on treating acne vulgaris.

Symptoms of gonorrhea in men include:

* A burning sensation when urinating
* Discharge from the penis
* Painful or swollen testicles
* Painful urination

Symptoms of gonorrhea in women include:

* Increased vaginal discharge
* Painful urination
* Painful intercourse
* Abnormal vaginal bleeding

Gonorrhea can be diagnosed through a physical exam and laboratory tests, such as a urine test or a swab of the affected area. It is typically treated with antibiotics.

If left untreated, gonorrhea can cause serious complications, including:

* Pelvic inflammatory disease (PID) in women
* Epididymitis (inflammation of the tube that carries sperm) in men
* Infertility
* Chronic pain
* Increased risk of HIV transmission

Gonorrhea is a reportable disease, meaning that healthcare providers are required by law to report cases to public health authorities. This helps to track and prevent the spread of the infection.

Prevention methods for gonorrhea include:

* Safe sex practices, such as using condoms or dental dams
* Avoiding sexual contact with someone who has gonorrhea
* Getting regularly tested for STIs
* Using pre-exposure prophylaxis (PrEP) for HIV prevention

It is important to note that gonorrhea can be asymptomatic, meaning that individuals may not experience any symptoms even if they have the infection. Therefore, regular testing is important for early detection and treatment.

The symptoms of cholera include:

1. Diarrhea: Cholera causes profuse, watery diarrhea that can last for several days.
2. Dehydration: The loss of fluids and electrolytes due to diarrhea can lead to severe dehydration, which can be life-threatening if not treated promptly.
3. Nausea and vomiting: Cholera patients may experience nausea and vomiting, especially in the early stages of the disease.
4. Abdominal cramps: The abdomen may become tender and painful due to the inflammation caused by the bacteria.
5. Low-grade fever: Some patients with cholera may experience a mild fever, typically less than 102°F (39°C).

Cholera is spread through the fecal-oral route, which means that it is transmitted when someone ingests food or water contaminated with the bacteria. The disease can also be spread by direct contact with infected fecal matter, such as through poor hygiene practices or inadequate waste disposal.

There are several ways to diagnose cholera, including:

1. Stool test: A stool sample can be tested for the presence of Vibrio cholerae using a microscope or a rapid diagnostic test (RDT).
2. Blood test: A blood test can detect the presence of antibodies against Vibrio cholerae, which can indicate that the patient has been infected with the bacteria.
3. Physical examination: A healthcare provider may perform a physical examination to look for signs of dehydration and other symptoms of cholera.

Treatment of cholera typically involves replacing lost fluids and electrolytes through oral rehydration therapy (ORT) or intravenous fluids. Antibiotics may also be given to shorten the duration of diarrhea and reduce the risk of complications. In severe cases, hospitalization may be necessary to provide more intensive treatment.

Prevention of cholera involves maintaining good hygiene practices, such as washing hands with soap and water, and avoiding consumption of contaminated food and water. Vaccines are also available to protect against cholera, particularly for people living in areas where the disease is common.

In conclusion, cholera is a highly infectious disease that can cause severe dehydration and even death if left untreated. Early diagnosis and treatment are critical to preventing complications and reducing the risk of transmission. Prevention measures such as vaccination and good hygiene practices can also help control the spread of the disease.

In women, urethritis is more common than in men due to the shorter length of their urethra and their closer proximity to the anus, which can increase the risk of bacterial infection. In addition, certain sexually transmitted infections (STIs), such as chlamydia and gonorrhea, can cause urethritis in both men and women.

If you suspect that you or a partner may have urethritis, it is important to seek medical attention as soon as possible. Untreated urethritis can lead to complications such as recurrent infections, infertility, and an increased risk of certain types of cancer. A healthcare provider can diagnose urethritis by performing a physical examination, taking a urine sample for testing, and possibly performing additional tests such as a pelvic exam or ultrasound to rule out other conditions. With prompt and appropriate treatment, however, most cases of urethritis can be effectively managed and cured.

... blocks the A-site so that a hydrogen bond is not formed between the amino acids. Tetracycline binds to the 30S and ... Tetracycline, sold under various brand names, is an oral antibiotic in the tetracyclines family of medications, used to treat a ... Tetracycline tablets were used in the plague outbreak in India in 1994. Tetracycline is first-line therapy for Rocky Mountain ... The term "tetracycline" is also used to denote the four-ring system of this compound; "tetracyclines" are related substances ...

https://en.wikipedia.org/wiki/Tetracycline

The discovery of tetracycline engendered an enormous amount of litigation. In late 1958, the U.S. government charged Pfizer and ... The government also sought to cancel the Pfizer patent on tetracycline, alleging fraud and the concealment of information that ... According to the indictment of American Cyanamid, Bristol Myers, Pfizer, and Cyanamid knew that tetracycline represented a ... Under the settlement, American Cyanamid, which had acquired Heyden Chemicals's pending tetracycline application, conceded the ...

https://en.wikipedia.org/wiki/Tetracycline_litigation

Tetracyclines are composed of a rigid skeleton of 4 fused rings. The rings structure of tetracyclines is divided into an upper ... Tetracycline resistance is often due to the acquisition of new genes, which code for energy-dependent efflux of tetracyclines ... Tetracyclines inhibit protein synthesis in both bacterial and human cells. Bacteria have a system that allows tetracyclines to ... Tetracyclines remain the treatment of choice for some specific indications. Because not all of the tetracycline administered ...

https://en.wikipedia.org/wiki/Tetracycline_antibiotics

Introduction of tetracycline results in binding of one tetracycline on each TetR homodimer followed by release of TetO2 by the ... The difference relates to their respective response to tetracycline or doxycycline (Dox, a more stable tetracycline analogue); ... Tetracycline-controlled gene expression is based upon the mechanism of resistance to tetracycline antibiotic treatment found in ... and a linear dose-response to tetracycline analogs. In the most commonly used plasmids, the tetracycline response element ...

https://en.wikipedia.org/wiki/Tetracycline-controlled_transcriptional_activation

As with related tetracycline antibiotics, demeclocycline acts by binding to the 30S ribosomal subunit to inhibit binding of ... Like other tetracyclines, demeclocycline is contraindicated in children and pregnant or nursing women. All members of this ... Tetracyclines bind to cations, such as calcium, iron (when given orally), and magnesium, rendering them insoluble and ... These are similar to those of other tetracyclines. Skin reactions with sunlight have been reported. Like only few other known ...

https://en.wikipedia.org/wiki/Demeclocycline

"Tetracycline (doxycycline, minocycline)". Markel, A (October 2005). "Allopurinol-induced DRESS syndrome" (PDF). Israel Medical ...

https://en.wikipedia.org/wiki/Drug_reaction_with_eosinophilia_and_systemic_symptoms

Tetracycline and minocycline. Tetracycline is a broad-spectrum antibiotic, and its derivative minocycline is common in the ... If heavy staining or tetracycline damage is present on a patient's teeth, and whitening is ineffective (tetracycline staining ... Sánchez, AR; Rogers RS, 3rd; Sheridan, PJ (October 2004). "Tetracycline and other tetracycline-derivative staining of the teeth ... Later, the tetracycline is oxidized and the staining becomes more brown and no longer fluoresces under UV light. Porphyria: A ...

https://en.wikipedia.org/wiki/Tooth_whitening

Charest, M. G.; Siegel, D. R.; Myers, A. G. (2005). "Synthesis of (-)-tetracycline". Journal of the American Chemical Society. ... tetracycline was prepared with a Diels-Alder reaction. Thermally initiated, conrotatory opening of the benzocyclobutene ... generated the o-quinodimethane, which reacted intermolecularly to give the tetracycline skeleton; the diastereomer shown was ...

https://en.wikipedia.org/wiki/Diels–Alder_reaction

... is a tetracycline antibiotic. Tetracycline is N-Mannich base prodrug that is prepared from tetracycline by ... Tetracycline antibiotics, Pyrrolidines, Triketones, All stub articles, Antibiotic stubs). ...

https://en.wikipedia.org/wiki/Rolitetracycline

As a tetracycline derivative antibiotic, its structural modifications has expanded its therapeutic activity to include Gram- ... As a tetracycline derivative, tigecycline exhibits similar side effects to the class of antibiotics. Gastrointestinal (GI) ... These interactions are not observed in the binding of tetracycline. The findings indicate that tigecycline likely has a unique ... It is a third-generation tetracycline derivative within a class called glycylcyclines which carry a N,N-dimethyglycylamido (DMG ...

https://en.wikipedia.org/wiki/Tigecycline

... is a tetracycline antibiotic. It is used as a precursor in the industrial synthesis of doxycycline hyclate. It has ... Tetracycline antibiotics, Triketones, All stub articles, Antibiotic stubs). ...

https://en.wikipedia.org/wiki/Metacycline

Most studies in tetracyclines and CMTs showed that they can inhibit MMP activity. One CMT called COL-3 or metastat has been ... Tetracyclines are antibiotics that also exhibit MMP inhibitory activity. They chelate Zn2+ ion, thereby inhibiting MMP activity ... Doxycycline is a semi-synthetic tetracycline that has been studied for dental and medical applications. Its effects on diseases ... Advantages of CMT over conventional tetracyclines are that chronic use does not result in gastrointestinal toxicity and higher ...

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Tetracycline Consumption in Prehistory. In Tetracyclines in Biology, Chemistry and Medicine. M. Nelson, W. Hillen, and R.A. ... Tetracycline Labeled Human Bone from Prehistoric Sudanese Nubia (A.D. 350). Science 209:1532 1534. Peter Farb and George J. ... Spectroscopic Characterization of Tetracycline in Skeletal Remains of an Ancient Population from Sudanese Nubia 350CE-550CE. ...

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... (INN) is a tetracycline antibiotic. It is used topically (i.e. for skin infections) as it is totally insoluble in ... Tetracycline antibiotics, Triketones, All stub articles, Antibiotic stubs, Dermatologic drug stubs). ...

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Once the KRAB domain was fused to the tetracycline repressor (TetR), the TetR-KRAB fusion proteins were the first engineered ... Deuschle U, Meyer WK, Thiesen HJ (April 1995). "Tetracycline-reversible silencing of eukaryotic promoters". Mol. Cell. Biol. 15 ...

https://en.wikipedia.org/wiki/Krüppel_associated_box

Improvement with tetracyclines is usually seen after 4 days and significantly so after 2 weeks. Most commonly in women between ... These include tetracycline, doxycycline, and erythromycin. Erythromycin may be used as a cream. Doxycycline is most often the ... Treatment is typically by stopping topical steroids, changing cosmetics, and in more severe cases, taking tetracyclines by ...

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Behal V (1987). "The tetracycline fermentation and its regulation". CRC Crit. Rev. Biotechnol. 5: 295-318. Portal: Biology v t ... This enzyme participates in tetracycline biosynthesis and biosynthesis of type ii polyketide products. ...

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... typically binds tetracycline-Mg2+ complexes inside bacteria, but TetR binding to tetracycline alone has been observed in ... There is a binding cavity for tetracycline in the outer helices of the regulatory domain. When tetracycline binds this cavity, ... Tetracycline (Tc) is a broad family of antibiotics to which bacteria have evolved resistance. Tc normally kills bacteria by ... Tetracycline controlled transcriptional activation Ramos JL, Martínez-Bueno M, Molina-Henares AJ, Terán W, Watanabe K, Zhang X ...

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Tetracycline may also trigger the condition. The diagnosis is based on symptoms and a high opening pressure found during a ... long-term tetracycline antibiotics (for a variety of skin conditions) and hormonal contraceptives. There are numerous other ...

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Deuschle, U.; Meyer, W. K.; Thiesen, H. J. (April 1995). "Tetracycline-reversible silencing of eukaryotic promoters". Molecular ... enabled identification of other transcription regulatory domains and gene regulatory technologies including tetracycline- ...

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Tetracycline is typically an effective treatment. V. alginolyticus is rare cause of bacteremia in immunocompromised hosts. ...

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Treatment with tetracycline antibiotics is usually successful.[citation needed] Kurland, Charles G.; Andersson, Siv G. E.; ...

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Popular antibiotics also include tetracycline and minocycline. Topical clindamycin has been shown to have an effect in double- ...

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N. risticii responds well to tetracycline antibiotics. Mild cases may be treated with oral doxycycline, while severe cases are ...

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Expired tetracyclines or tetracyclines allowed to stand at a pH less than 2 are reported to be nephrotoxic due to the formation ... Absorption of tetracycline occurs in the stomach and the upper small intestine. Absorption of tetracyclines has been reported ... Other tetracycline antibiotics are contraindicated in pregnancy and up to eight years of age, due to the potential for ... Nevertheless, tetracyclines and doxycycline itself have to be taken with caution in patients with kidney injury, as they can ...

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The condition responds to penicillin, and where allergies to it occur, erythromycin or tetracyclines are used. When proper ... Treatment is with penicillin, tetracycline, or doxycycline. This condition is diagnosed by detecting the bacteria in skin, ...

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Some other tetracycline drugs are also effective. In general, patients with symptoms of HGA and unexplained fever after a tick ...

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Yap, LM; Foley, PA; Crouch, RB; Baker, CS (August 2000). "Drug-induced solar urticaria due to tetracycline". The Australasian ... Another patient was being treated with the antibiotic tetracycline for a separate dermatological disorder and broke out in ... hives when exposed to the sun, the first case to implicate tetracycline as a solar urticaria inducing agent. It is not yet ...

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Tetracycline-Resistant Neisseria gonorrhoeae -- Georgia, Pennsylvania, New Hampshire Since February 1985, CDC has identified 12 ... All were resistant to tetracycline (MIC 16-32 ug/ml), doxycycline (MIC 8-24 ug/ml), and minocycline (MIC 12-32 ug/ml). The ... Editorial Note: This is the first report of multiple isolates of N. gonorrhoeae resistant to tetracycline at this high level. ... In light of this new development, CDC strongly urges that all positive test-of-cure cultures be screened for tetracycline ...

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Minocycline, tetracycline PO4, methacycline, doxycycline, tetracycline base, oxytetracycline HCl and tetracycline HCl were ... Tetracycline is active against a wide range of gram-negative and gram-positive organisms. The drugs in the tetracycline class ... A tetracycline disk may be used to determine microbial susceptibility to drugs in the tetracycline class. If the Kirby-Bauer ... Tetracycline is a yellow, odorless, crystalline powder. Tetracycline is stable in air but exposure to strong sunlight causes it ...

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Testing Status of Tetracycline hydrochloride 10381-S. Testing Status of Tetracycline hydrochloride 10381-S. CASRN: 64-75-5. ... Toxicology and Carcinogenesis Studies of Tetracycline Hydrochloride (CASRN 64-75-5) in F344/N Rats and B6C3F1 Mice (Feed ...

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Tetracycline: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Tetracycline comes as a capsule to take by mouth. It is usually taken two or four times daily. Tetracycline should be taken on ... Take tetracycline 2 hours before or 4 hours after iron preparations and vitamin products that contain iron. Take tetracycline 2 ... Before taking tetracycline,. *tell your doctor and pharmacist if you are allergic to tetracycline, minocycline, doxycycline, ...

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Minocycline and other tetracycline analogs are well known for causing discoloration of developing teeth in children. However, ... Dental and oral discolorations associated with minocycline and other tetracycline analogs J Esthet Dent. 1999;11(1):43-8. doi: ... Clinical significance: Minocycline and other tetracycline analogs are well known for causing discoloration of developing teeth ... It has been well acknowledged in recent literature that minocycline, a semisynthetic tetracycline derivative, causes ...

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Tetracycline Tetracycline is used to treat infections caused by bacteria including pneumonia and other respiratory tract ... Bismuth, Metronidazole, and Tetracycline Bismuth, metronidazole, and tetracycline is used along with other ulcer medications to ... Tetracycline and Pregnancy (Organization of Teratology Information Specialists) - PDF Pregnancy and Medicines/Specifics ... ... injection is in a class of medications called tetracycline antibiotics. It works by killing bacteria that cause ... if you are ...

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Humphrey, J. H., Lightbown, J. W. & Mussett, Marjorie V. (‎1957)‎. International Standard for Tetracycline. Bulletin of the ...

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... dental enamel or bone deposition of tetracyclines. However, a close examination of available literature indicates that there is ... A number of reviews have stated that tetracycline is contraindicated during breastfeeding because of possible staining of ... Tetracycline No authors listed In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of ... Short-term use of tetracycline is acceptable in nursing mothers. As a theoretical precaution, avoid prolonged or repeat courses ...

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Tetracycline has fallen out of favor because it usually must be administered three times daily, a relatively inconvenient ... Tetracyclines should be stored at room temperature in light-tight containers.. Dosage adjustments are required if tetracycline ... Tetracyclines have potential to be toxic to the kidney. It is best to pick another drug in a patient with pre-existing kidney ... Tetracycline has become expensive and difficult to obtain but is still in use as it has a unique ability to penetrate cells and ...

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Short-term use of tetracycline is acceptable in nursing mothers. As a theoretical precaution, avoid prolonged or repeat courses ... a close examination of available literature indicates that there is not likely to be harm in short-term use of tetracycline ... dental enamel or bone deposition of tetracyclines. However, ... A number of reviews have stated that tetracycline is ... After a single dose of 150 mg of tetracycline orally in 2 women, milk levels of tetracycline averaged 0.7 mg at 2 and 6 hours ...

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ICD-10 code T36.4X6D for Underdosing of tetracyclines, subsequent encounter is a medical classification as listed by WHO under ... Underdosing of tetracyclines, subsequent encounter T36. Excludes1: antineoplastic antibiotics (T45.1-). locally applied ... ICD-10-CM Code for Underdosing of tetracyclines, subsequent encounter T36.4X6D ICD-10 code T36.4X6D for Underdosing of ... tetracyclines, subsequent encounter is a medical classification as listed by WHO under the range - Injury, poisoning and ...

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All were resistant to tetracycline (MIC 16-32 ug/ml), doxycycline (MIC 8-24 ug/ml), and minocycline (MIC 12-32 ug/ml). (cdc.gov)
It has been well acknowledged in recent literature that minocycline, a semisynthetic tetracycline derivative, causes discolorations in adult teeth and various other collagenous tissues. (nih.gov)
This article presents the most common patterns of minocycline staining in addition to comparing the staining patterns of other tetracycline analogs in the permanent dentition. (nih.gov)
Minocycline and other tetracycline analogs are well known for causing discoloration of developing teeth in children. (nih.gov)
tell your doctor and pharmacist if you are allergic to tetracycline, minocycline, doxycycline, demeclocycline, any other medications, or any of the ingredients in the tetracycline capsule. (medlineplus.gov)
Minocycline is in a class of medications called tetracycline antibiotics. (nih.gov)
Tetracycline has since been supplanted, at least in small animal medicine, by minocycline and doxycycline , which have less side effects potential and more convenient dosing schedules. (marvistavet.com)
More modern forms of tetracycline include doxycycline and minocycline which are much more commonly used and have similar indications. (nih.gov)
Chronic therapy with tetracycline is effective in ameliorating acne, but because of their better absorption and tissue penetration, minocycline and doxycycline have largely replaced tetracycline for this indication. (nih.gov)

Tetracycline is in a class of medications called tetracycline antibiotics. (medlineplus.gov)
Antibiotics such as tetracycline will not work for colds, flu, or other viral infections. (medlineplus.gov)
This syndrome is rarely seen currently as tetracycline is no longer available in parenteral form and the use of intravenous tetracyclines has been superseded by availability of safer, better tolerated and more effective broad spectrum antibiotics. (nih.gov)

Take tetracycline exactly as directed. (medlineplus.gov)
Take tetracycline 2 hours before or 6 hours after antacids, calcium supplements, zinc products, and laxatives containing magnesium. (medlineplus.gov)
Take tetracycline 2 hours before or 4 hours after iron preparations and vitamin products that contain iron. (medlineplus.gov)
Take tetracycline 2 hours before or after zinc containing products. (medlineplus.gov)
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Editorial Note: This is the first report of multiple isolates of N. gonorrhoeae resistant to tetracycline at this high level. (cdc.gov)
Up to 44 percent of strains of Streptococcus pyogenes and 74 percent of Streptococcus faecalis have been found to be resistant to tetracycline drugs. (nih.gov)

For people who have been exposed to anthrax but do not have symptoms, 60 days of ciprofloxacin, a tetracycline (including doxycycline), or penicillin is given to reduce the risk or progression of disease due to inhaled anthrax. (medscape.com)
When the dual transgenic mice are fed tetracycline or doxycycline, the transgene is activated in glomerular podocytes. (nih.gov)

High doses of several forms of tetracycline given intravenously have been associated with acute fatty liver that can be severe and result in liver failure and death. (nih.gov)

Store Tetracycline at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed, light-resistant container. (canadianpharm.org)

Tetracycline can cause staining of developing teeth (in children or when taken by a pregnant mother). (nih.gov)

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Tetracycline was first approved for use in the United States in 1957 and was one of several oral tetracyclines used at that time (oxytetracycline, chlortetracycline), many of which are no longer available or are used in veterinary medicine only. (nih.gov)

Since February 1985, CDC has identified 12 isolates of Neisseria gonorrhoeae that have high-level resistance to tetracycline (minimal inhibition concentration (MIC) 24-32 ug/ml) but are susceptible to penicillin. (cdc.gov)
Therefore, tetracyclines should not be used for streptococcal disease unless the organisms have been demonstrated to be susceptible. (nih.gov)
If the Kirby-Bauer method of disk susceptibility testing is used, a 30 mcg tetracycline disk should give a zone of at least 19 mm when tested against a tetracycline susceptible bacterial strain. (nih.gov)
Tetracycline is an oral, broad-spectrum antibiotic used to treat mild-to-moderate infections due to susceptible microbial organisms. (nih.gov)

Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis. (nih.gov)
Tetracycline acts by inhibition of protein synthesis by binding to the 30S subunit of microbial ribosomes. (nih.gov)

Six patients were initially treated with oral tetracycline alone. (cdc.gov)
Oral tetracycline use has been rarely and not very convincingly linked to acute hepatic injury. (nih.gov)
Tetracycline is an oral, broad-spectrum antibiotic and semisynthetic derivative of Streptomyces actinobacteria. (nih.gov)
Oral tetracycline has been associated with rare instances of acute liver injury, but the association with tetracycline use as opposed to other agents being taken has not always been very well shown. (nih.gov)
Despite frequency of its use, oral tetracycline remains a very rare cause of liver injury. (nih.gov)
digoxin, methotrexate, methoxyflurane, or oral anticoagulants (warfarin) because the risk of their side effects may be increased by Tetracycline. (canadianpharm.org)

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Tetracycline comes as a capsule to take by mouth. (medlineplus.gov)
tablet, and one tetracycline capsule to take together by mouth. (nih.gov)

The tetracycline antibiotic family provides broad anti-bacterial protection by inhibiting bacterial protein synthesis. (marvistavet.com)
In other words, tetracycline binds to bacterial protein-synthesis structures but not to mammalian ones. (marvistavet.com)
Another use would be the treatment of a feline condition known as a "Tetracycline Responsive Abscess" where draining abscesses are caused by "L-form" bacteria (a bacterial type that lacks a cell wall). (marvistavet.com)
Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline. (nih.gov)
Diversity of Tetracycline Resistance Among Bacterial Isolates from Swi" by Craig D. Adams, J Macauley et al. (usu.edu)
Tetracycline is a broad-spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria, indicated for use against many bacterial infections. (radjay.com)
Tetracycline is a broad-spectrum polyketide antibiotic used to treat certain bacterial infections of the lungs, skin, and sexually transmitted diseases (STD). (cryptocoinpharma.com)
Tetracycline exerts its bacteriostatic effect by passively diffuses through porin channels in the bacterial membrane and reversibly binding to the ribosome's 30S subunits, thereby preventing the binding of aminoacyl transfer RNA to messenger RNA-ribosome complex and inhibiting protein synthesis, thus arresting cell growth. (cryptocoinpharma.com)

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Each capsule contains 250 mg of Tetracycline as its active ingredient. (cryptocoinpharma.com)

Bismuth, metronidazole, and tetracycline is used along with other ulcer medications to treat duodenal ulcers. (nih.gov)

Tetracycline is available in multiple generic forms as capsules or tablets of 250 and 500 mg and generally recommended in doses of 250 to 500 mg three to four times daily for 7 to 30 days. (nih.gov)
High doses of intravenous tetracycline can induce fatty liver disease and may result in severe hepatic dysfunction, acute liver failure and death. (nih.gov)
Tetracycline is an antibiotic, and in high doses can permanently stain teeth. (flaxdental.com)

you should know that when tetracycline is used during pregnancy or in babies or children up to age 8, it can cause the teeth to become permanently stained. (medlineplus.gov)

Tetracycline does not kill bacteria, it merely curtails their ability to reproduce. (marvistavet.com)
Tetracycline is used to treat infections caused by certain bacteria. (canadianpharm.org)

Antacids commonly contain calcium, which binds tetracycline in the GI tract. (marvistavet.com)

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However, instances of acute fatty liver attributed to intravenous tetracycline have been reported in nonpregnant women and in men and even in children. (nih.gov)

Silagra is a generic version of the brand name drug called Viagra does tetracycline cure std. (vivalaslearn.com)

Tetracyclines are readily absorbed and are bound to plasma protein in varying degrees. (nih.gov)

This list does not include all medicines that may interact with Tetracycline. (cryptocoinpharma.com)

This was a 28-year-old homosexual male who had positive posttreatment cultures from both the rectum and pharynx after initial treatment with tetracycline for gonococcal infection at those sites. (cdc.gov)
Currently, tetracycline is most frequently used for upper respiratory and skin and soft tissue infection and more than 2 million prescriptions are filled yearly. (nih.gov)

Drink a full glass of water with each dose of tetracycline. (medlineplus.gov)
If you miss a dose of Tetracycline, take it as soon as possible. (canadianpharm.org)
If you think you may have used Tetracycline more than the usual dose, please seek medical help immediately. (cryptocoinpharma.com)

Tetracycline is also sometimes used to treat Lyme disease and malaria, and to prevent plague and tularemia in people who have been exposed to plague or tularemia germs. (medlineplus.gov)
Tetracycline is also active against infections with several rickettsial, spirochetal, chlamydial and mycoplasmas infections and are often used for therapy of nonspecific urethritis and several Rickettsia diseases, such as Rocky Mountain spotted fever and Lyme disease. (nih.gov)

Long term use may induce actual urinary stones made of tetracycline (a rare but interesting complication). (marvistavet.com)

Tetracycline should be taken on an empty stomach, at least 1 hour before or 2 hours after meals or snacks. (medlineplus.gov)
The administration of sucralfate (as might be used in the event of stomach ulcers) should be staggered with tetracycline by a couple of hours. (marvistavet.com)

When it comes to hard-to-remove stains, like those from tetracycline, the ballgame changes a little. (flaxdental.com)
The management of patients with stains by tetracycline is complicated depending on the degree of stain that each patient presents when attending These situations may occur and the professional should be properly prepared to handle these cases. (bvsalud.org)

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Nausea and vomiting are the most commonly reported side effects of tetracycline in dogs and cats, particularly cats. (marvistavet.com)
Nausea may result if tetracycline is used in combination with theophylline (an airway dilator). (marvistavet.com)

Tetracycline may cause side effects. (medlineplus.gov)

Anatomy2

Organisms13

Diseases4

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes18

Information Science2

Health Care1

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (1/2398)

Assessment of hepatotoxic potential. (2/2398)

Endemic tropical sprue in Rhodesia. (3/2398)

In vivo chaperone activity of heat shock protein 70 and thermotolerance. (4/2398)

Inducible long-term gene expression in brain with adeno-associated virus gene transfer. (5/2398)

Transcriptional regulation and induction of apoptosis: implications for the use of monomeric p53 variants in gene therapy. (6/2398)

The stability and fate of a spliced intron from vertebrate cells. (7/2398)

Functional importance and local environments of the cysteines in the tetracycline resistance protein encoded by plasmid pBR322. (8/2398)

Tetracycline

Tetracyclines

Tetracycline Resistance

Oxytetracycline

Anti-Bacterial Agents

Minocycline

Doxycycline

R Factors

Drug Resistance, Microbial

Microbial Sensitivity Tests

Chlortetracycline

Demeclocycline

Conjugation, Genetic

Erythromycin

Chloramphenicol

Escherichia coli

Drug Resistance, Bacterial

DNA Transposable Elements

DNA, Bacterial

Drug Resistance, Multiple, Bacterial

Plasmids

Spectinomycin

Streptomycin

Antiporters

Methacycline

Bacterial Proteins

Genes, Bacterial

Neisseria gonorrhoeae

Penicillin Resistance

Bacteroides

Ampicillin

Furazolidone

Rolitetracycline

Metronidazole

Clindamycin

Penicillins

Acne Vulgaris

Extrachromosomal Inheritance

Chloramphenicol Resistance

Trimethoprim

Lincomycin

Molecular Sequence Data

Ureaplasma

Gonorrhea

Enterococcus faecalis

Kanamycin

Staphylococcus

Feces

Chromosomes, Bacterial

Microscopy, Ultraviolet

Drug Residues

Electrophoresis, Gel, Pulsed-Field

Bismuth

Staphylococcus aureus

Streptococcus

Transformation, Bacterial

Macrolides

Streptomyces aureofaciens

Cholera

Anti-Infective Agents

Base Sequence

Salmonella

Shigella

Sulfisoxazole

Culture Media

Ciprofloxacin

Sulfamethoxazole

Repressor Proteins

Disk Diffusion Antimicrobial Tests

Campylobacter

Helicobacter pylori

Integrons

Drug Resistance, Multiple

Mutation

Urethritis

Bacteriophage Typing

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (1/2398)

Assessment of hepatotoxic potential. (2/2398)

Endemic tropical sprue in Rhodesia. (3/2398)

In vivo chaperone activity of heat shock protein 70 and thermotolerance. (4/2398)