A potent local anesthetic of the ester type used for surface and spinal anesthesia.
A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)
A species of the family Ranidae occurring in a wide variety of habitats from within the Arctic Circle to South Africa, Australia, etc.
Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.
An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.
Procedure in which an anesthetic is injected directly into the spinal cord.
Venoms produced by frogs, toads, salamanders, etc. The venom glands are usually on the skin of the back and contain cardiotoxic glycosides, cholinolytics, and a number of other bioactive materials, many of which have been characterized. The venoms have been used as arrow poisons and include bufogenin, bufotoxin, bufagin, bufotalin, histrionicotoxins, and pumiliotoxin.
The techniques used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders such as erythrocytosis, hemochromatosis, polycythemia vera, and porphyria cutanea tarda.
A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.
An inert iodine-containing agent which is opaque to X-RAYS. It is used mainly for BRAIN and SPINAL CORD visualization.
Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.

Effects of tetracaine on sarcoplasmic calcium release in mammalian skeletal muscle fibres. (1/340)

1. Single muscle fibres were dissociated enzymatically from the extensor digitorum communis muscle of rats. The fibres were mounted into a double Vaseline gap experimental chamber and the events in excitation-contraction coupling were studied under voltage clamp conditions in the presence and absence of the local anaesthetic tetracaine. 2. Changes in intracellular calcium concentration ([Ca2+]i) were monitored using the calcium sensitive dyes antipyrylazo III and fura-2 and the rate of calcium release (Rrel) from the sarcoplasmic reticulum (SR) was calculated. Tetracaine decreased the maximal attained [Ca2+]i and suppressed, in a dose-dependent manner, both the early peak and the steady level of Rrel in the voltage range examined. 3. The concentration dependence of the effects on the two kinetic components of Rrel were almost identical with a half-effective concentration (K50) of 70 and 71 microM and a Hill coefficient (nH) of 2.7 and 2.3 for the peak and the steady level, respectively. Furthermore, the drug did not alter the peak to steady level ratio up to a concentration (50 microM) that caused a 35 +/- 5 % reduction in calcium release. Higher concentrations did suppress the ratio but the degree of suppression was voltage independent. 4. Tetracaine (50 microM) neither influenced the total available intramembrane charge nor altered its membrane potential dependence. It shifted the transfer function, the normalized SR permeability versus normalized charge to the right, indicating that similar charge transfer caused a smaller increase in SR permeability. 5. To explore the site of action of tetracaine further the ryanodine receptor (RyR) calcium release channel of the SR was purified and reconstituted into planar lipid bilayers. The reconstituted channel had a conductance of 511 +/- 14 pS (n = 8) in symmetric 250 mM KCl that was not affected by tetracaine. Tetracaine decreased the open probability of the channel in a concentration-dependent manner with K50 = 68 microM and nH = 1.5. 6. These experiments show that tetracaine suppresses SR calcium release in enzymatic isolated mammalian skeletal muscle fibres. This effect is due, presumably, to the decreased open probability of the RyR in the presence of the drug. Since both the inactivating peak and the steady level of Rrel were equally affected by tetracaine, our observations suggest that there is a tight coupling between these kinetic components of SR calcium release in mammalian skeletal muscle.  (+info)

Interaction of bupivacaine and tetracaine with the sarcoplasmic reticulum Ca2+ release channel of skeletal and cardiac muscles. (2/340)

BACKGROUND: Although various local anesthetics can cause histologic damage to skeletal muscle when injected intramuscularly, bupivacaine appears to have an exceptionally high rate of myotoxicity. Research has suggested that an effect of bupivacaine on sarcoplasmic reticulum Ca2+ release is involved in its myotoxicity, but direct evidence is lacking. Furthermore, it is not known whether the toxicity depends on the unique chemical characteristics of bupivacaine and whether the toxicity is found only in skeletal muscle. METHODS: The authors studied the effects of bupivacaine and the similarly lipid-soluble local anesthetic, tetracaine, on the Ca2+ release channel-ryanodine receptor of sarcoplasmic reticulum in swine skeletal and cardiac muscle. [3H]Ryanodine binding was used to measure the activity of the Ca2+ release channel-ryanodine receptors in microsomes of both muscles. RESULTS: Bupivacaine enhanced (by two times at 5 mM) and inhibited (66% inhibition at 10 mM) [3H]ryanodine binding to skeletal muscle microsomes. In contrast, only inhibitory effects were observed with cardiac microsomes (about 3 mM for half-maximal inhibition). Tetracaine, which inhibits [3H]ryanodine binding to skeletal muscle microsomes, also inhibited [3H]ryanodine binding to cardiac muscle microsomes (half-maximal inhibition at 99 microM). CONCLUSIONS: Bupivacaine's ability to enhance Ca2+ release channel-ryanodine receptor activity of skeletal muscle sarcoplasmic reticulum most likely contributes to the myotoxicity of this local anesthetic. Thus, the pronounced myotoxicity of bupivacaine may be the result of this specific effect on Ca2+ release channel-ryanodine receptor superimposed on a nonspecific action on lipid bilayers to increase the Ca2+ permeability of sarcoplasmic reticulum membranes, an effect shared by all local anesthetics. The specific action of tetracaine to inhibit Ca2+ release channel-ryanodine receptor activity may in part counterbalance the nonspecific action, resulting in moderate myotoxicity.  (+info)

Topical anaesthesia of intact skin: liposome-encapsulated tetracaine vs EMLA. (3/340)

In this randomized, double-blind study, we have compared the ability of 5% liposome-encapsulated tetracaine (amethocaine) (LET) vs 5% eutectic mixture of local anaesthetics (EMLA) to produce local anaesthesia of intact skin in 40 healthy volunteers. Volunteers had both preparations applied to their forearms under an occlusive dressing for 1 h. Superficial anaesthesia was measured by a total of nine 1-mm pinpricks on each arm. Deeper anaesthesia was assessed by single insertion of a sterile 22-gauge needle to a depth of 3 mm and pain was reported on a visual analogue scale (VAS). If the volunteer perceived greater than four of the 1-mm pinpricks, the 3-mm insertion was not performed. Results showed that the number of pinpricks perceived was significantly less (P < 0.01) for LET (median 1.0; range 0-9) vs EMLA (1.5; 0-9). In volunteers who had deeper anaesthesia assessed, there was no significant difference (P = 0.065) in VAS scores for LET (mean 1.5 (SD 1.4); n = 34) vs EMLA (2.4 (2.1); n = 28). Overall anaesthetic effect, as ranked by all of the subjects, was significantly better for LET compared with EMLA (P = 0.024). We have demonstrated that when applied in equal volumes, 5% LET produced better superficial local anaesthesia than EMLA.  (+info)

Isolation and characterization of the yeast las21 mutants, which are sensitive to a local anestheticum, tetracaine. (4/340)

We isolated and characterized yeast mutants whose growth is sensitive to a local anestheticum tetracaine and, at the same time, temperature sensitive. These mutants were collectively called las mutants (local anestheticum sensitive). The las21 mutants were analyzed in this study. The wild type LAS21 gene was cloned by exploiting temperature sensitivity of the las21 mutants and we found that LAS21 encodes ORF YJL062w which has not been analyzed before. Las21p is putative membrane protein belonging to the major facilitator super family containing plural membrane spanning domains. Complete elimination of the LAS21 ORF did not kill the cells but made their growth temperature sensitive. Interestingly, the complete loss of the LAS21 gene canceled the sensitivity to tetracaine. The ability of the las21 mutants to grow at a higher temperature was recovered in the various media containing an osmotic stabilizer or salts. Furthermore, temperature sensitivity of the las21 mutants was partially suppressed by introduction of PKC1, encoding protein kinase C, on a high copy vector. We found some genetic interactions between LAS21 and Ras/cAMP cascade genes. These results suggest that LAS21 defines unknown pathway regulating the stress response of yeast.  (+info)

Photoaffinity labeling the torpedo nicotinic acetylcholine receptor with [(3)H]tetracaine, a nondesensitizing noncompetitive antagonist. (5/340)

Tetracaine (N,N-dimethylaminoethyl-4-butylaminobenzoate) and related N,N-dialkylaminoethyl substituted benzoic acid esters have been used to characterize the high-affinity binding site for aromatic amine noncompetitive antagonists in the Torpedo nicotinic acetylcholine receptor (nAChR). [(3)H]Tetracaine binds at equilibrium to a single site with a K(eq) value of 0.5 microM in the absence of agonist or presence of alpha-bungarotoxin and with a K(eq) value of 30 microM in the presence of agonist (i.e., for nAChR in the desensitized state). Preferential binding to nAChR in the absence of agonist is also seen for N,N-DEAE and N,N-diethylaminopropyl esters, both binding with 10-fold higher affinity in the absence of agonist than in the presence, and for the 4-ethoxybenzoic acid ester of N, N-diethylaminoethanol, but not for the 4-amino benzoate ester (procaine). Irradiation at 302 nm of nAChR-rich membranes equilibrated with [(3)H]tetracaine resulted in covalent incorporation with similar efficiency into nAChR alpha, beta, gamma, and delta subunits. The pharmacological specificity of nAChR subunit photolabeling as well as its dependence on [(3)H]tetracaine concentration establish that the observed photolabeling is at the high-affinity [(3)H]tetracaine-binding site. Within alpha subunit, >/=95% of specific photolabeling was contained within a 20-kilodalton proteolytic fragment beginning at Ser(173) that contains the M1 to M3 hydrophobic segments. With all four subunits contributing to [(3)H]tetracaine site, the site in the closed channel state of the nAChR is most likely within the central ion channel domain.  (+info)

Identification of amino acids of the torpedo nicotinic acetylcholine receptor contributing to the binding site for the noncompetitive antagonist [(3)H]tetracaine. (6/340)

[(3)H]Tetracaine is a noncompetitive antagonist of the Torpedo nicotinic acetylcholine receptor (nAChR) that binds with high affinity in the absence of cholinergic agonist (K(eq) = 0.5 microM) and weakly (K(eq) = 30 microM) in the presence of agonist (i.e., to nAChR in the desensitized state). In the absence of agonist, irradiation at 302 nm of nAChR-rich membranes equilibrated with [(3)H]tetracaine results in specific photoincorporation of [(3)H]tetracaine into each nAChR subunit. In this report, we identify the amino acids of each nAChR subunit specifically photolabeled by [(3)H]tetracaine that contribute to the high-affinity binding site. Subunits isolated from nAChR-rich membranes photolabeled with [(3)H]tetracaine were subjected to enzymatic digestion, and peptides containing (3)H were purified by SDS-polyacrylamide gel electrophoresis followed by reversed phase HPLC. N-terminal sequence analysis of the isolated peptides demonstrated that [(3)H]tetracaine specifically labeled two sets of homologous hydrophobic residues (alphaLeu(251), betaLeu(257), gammaLeu(260), and deltaLeu(265); alphaVal(255) and deltaVal(269)) as well as alphaIle(247) and deltaAla(268) within the M2 hydrophobic segments of each subunit. The labeling of these residues establishes that the high-affinity [(3)H]tetracaine-binding site is located within the lumen of the closed ion channel and provides a definition of the surface of the M2 helices facing the channel lumen.  (+info)

Tetracaine can inhibit contractions initiated by a voltage-sensitive release mechanism in guinea-pig ventricular myocytes. (7/340)

1. Effects of tetracaine on membrane currents and cell shortening were measured with high resistance electrodes, single-electrode voltage clamp (switch clamp) and a video edge detector at 37 C in cardiac ventricular myocytes. 2. Sequential voltage steps from -65 mV to -40 and 0 mV were used to activate two mechanisms of excitation-contraction (EC) coupling separately. The step to -40 mV activated the voltage-sensitive release mechanism (VSRM); the step to 0 mV1 activated Ca2+-induced Ca2+ release (CICR) coupled to inward Ca2+ current (IL). 3. Exposure to 100-300 microM tetracaine inhibited VSRM contractions but not CICR contractions. Inhibition of VSRM contractions was independent of INa blockade. In contrast, 100 microM Cd2+ blocked IL and CICR contractions, but not VSRM contractions. Simultaneous application of both agents blocked both mechanisms of EC coupling. 4. Contraction-voltage relationships were sigmoidal when the VSRM was available. However, when the VSRM was inhibited with 100-300 microM tetracaine, contraction-voltage relationships became bell-shaped. The tetracaine-insensitive contractions were abolished by 0.1 microM ryanodine, indicating that they were dependent on release of SR Ca2+. 5. At a higher concentration (1 mM) tetracaine also inhibited IL and contractions triggered by IL; however, the time course of effects on IL and associated contractions were different than for VSRM contractions. 6. With continuous application of tetracaine, the VSRM remained inhibited although SR Ca2+ stores increased 4-fold as assessed with caffeine. CICR contractions were not inhibited and maximum amplitude of contraction was not reduced. 7. Rapid application of tetracaine just before and during test steps also inhibited VSRM contractions, but without significantly affecting sarcoplasmic reticulum (SR) Ca2+ stores or CICR contractions. Maximum amplitude of contraction was reduced. 8. Rapid application of tetracaine (100-300 microM) allows preferential inhibition of the VSRM and provides a pharmacological method to assess the contribution of the VSRM to EC coupling.  (+info)

Tetracaine gel vs EMLA cream for percutaneous anaesthesia in children. (8/340)

We have evaluated the anaesthetic effect of tetracaine gel 1 g, applied for 45 min, compared with EMLA cream 2 g, applied for 60 min, in a randomized, double-blind study in 60 children aged 3-15 yr. Venous cannulation was performed 15 min after removal of the EMLA cream (n = 20) and tetracaine gel (n = 20). Cannulation was performed up to 215 min after removal of the tetracaine gel in another 20 patients. Significantly lower pain scores were recorded by the children treated with tetracaine gel compared with EMLA cream (P < 0.02). Forty to 45% of children in the tetracaine groups reported no pain compared with only 10% in the EMLA group. Only minor adverse effects were observed. We conclude that tetracaine gel provided effective, rapid, long-lasting and safe local anaesthesia, and was significantly better than EMLA cream in reducing pain during venous cannulation in children using the recommended application periods for both formulations.  (+info)

Local Anesthetic Tetracaine 94-24-6 Without Side Effect 1.Basic View Tetracaine CAS NO.:94-24-6 Purity: 99% Molecular Formula: C15H24N2O2 Molecular Weight: 264.3633 Description: white powder Specification: USP Uses:Local anesthetic Packing:Foil bag...
This randomized controlled trial will assess the efficacy of topical amethocaine gel (Ametop) compared with placebo (Eucerin plus) in decreasing the pain response in term neonates subjected to intramuscular injection for administration of vitamin K. Neonatal pain response between groups will be assessed using the Neonatal Facial Action Coding System (NFCS) which is currently the gold standard for infant pain assessment, latency to first cry and cry duration. Parents (father) perception of infants pain will be assessed using a visual analogue scale (VAS) when possible.. Neonates will be randomized to receive either amethocaine gel or identical appearing placebo administered locally at the injection site (the upper part of the neonates thigh) using a pre-prepared syringe 30 minutes prior to the administration of vitamin K. The gel or placebo will be covered using a Saran wrap. Each neonate will be videotaped during the procedure. Parents (father) will be present during the procedure (observing) ...
China Local Anesthetic CAS 136-47-0 Tetracaine Hydrochloride (Tetracaine HCl), Find details about China Tetracaine Hydrochloride, Pharmaceutical Chemical from Local Anesthetic CAS 136-47-0 Tetracaine Hydrochloride (Tetracaine HCl) - Wuhan Lianshangwang Technology Co., Ltd.
Local Anesthetical Apis Tetracaine / Tetracaine HCl CAS 94-24-6 for Pain Killer picture from Wuhan JCJ Logis Co., Ltd. view photo of Tetracaine, Tetracaine HCl, Tetracaine Hydrochloride.Contact China Suppliers for More Products and Price.
Get updated listings of tetracaine hydrochloride manufacturers, tetracaine hcl suppliers and tetracaine hydrochloride exporters in India. These shown tetracaine hydrochloride companies from India are known for its product durability.
Buy factory Tetracaine Powder Online, China Raw Tetracaine powder for sale, Top Tetracaine Supplier price, Local anesthetic Drug Tetracaine material manufacturer wholesaler at steroidliquid.com, Pain RELIEF with Good Effect.
HeBei GuanLang Biotechnology Co.,Ltd provides Tetracaine hydrochloride (136-47-0) purchasing information,includeing Tetracaine hydrochloride purity : 99%,Lead Time,price.And provide Tetracaine hydrochloride to submit purchase information online.
Tetracaine Faure information about active ingredients, pharmaceutical forms and doses by Novartis, Tetracaine Faure indications, usages and related health products lists
Tetracaine - Get up-to-date information on Tetracaine side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Tetracaine
Best quality Tetracaine 94-24-6 94-24-6 Suppliers,provide Best quality Tetracaine 94-24-6 94-24-6 product and the products related with China (Mainland) Best quality Tetracaine 94-24-6 94-24-6 Crovell Biotech (Hebei) Co., Ltd. China (Mainland)
Medscape - Indication-specific dosing for Tetcaine, tetracaine ophthalmic (tetracaine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
High quality 99% Tetracaine Powder CAS 94-24-6 For Ophthalmology / Antipruritic / Spinal Anesthesia from China, Chinas leading Local Anesthetic Powder product market, With strict quality control Local Anesthetic Powder factories, Producing high quality 99% Tetracaine Powder CAS 94-24-6 For Ophthalmology / Antipruritic / Spinal Anesthesia products.
China Tetracaine CAS 94-24-6 as Anesthetic, Find details about China Undecylenate, Testosterone Enanthate from Tetracaine CAS 94-24-6 as Anesthetic - Wuhan Lianshangwang Technology Co., Ltd.
Hot sales products in Europe ,America and other countries Phenacetin CAS:62-44-2 Benzocaine CAS:94-09-7 Benzocaine hydrochloride CAS: Procaine CAS:59-46-1 Procaine hydrochloride CAS:51-05-8...
Physician reviewed lidocaine and tetracaine topical patient information - includes lidocaine and tetracaine topical description, dosage and directions.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...
Cationic local anesthetics have been reported to influence cellular responses to surface stimuli by interfering with the function of microtubules and microfilaments. Since unimpaired microtubule and microfilament functions are required by human polymorphonuclear leukocytes in order to respond normally to surface stimulation, we have studied effects of the local anesthetic, tetracaine on the function and morphology of these cells in vitro. Tetracaine (0.25--1.0 mM) significantly reduced extracellular release of the lysosomal enzymes, beta-glucuronidase and lysozyme from polymorphonuclear leukocytes exposed to serum-treated zymosan (a particulate stimulus), zymosan-treated serum (a soluble stimulus), and to the surface-active lectin, concanavalin A. Tetracaine also significantly reduced superoixde anion production (superoxide dismutase-inhibitable cytochrome c reduction) by these cells. Tetrancaine was not cytotoxic and its effects could be reversed completely by washing cells once with buffer. ...
This study investigated the efficacy and tolerability of lidocaine/tetracaine cream 7%/7% [S-Caine Peel] to prevent procedural pain in patients undergoing
Restricted Access Oops, it looks like you dont have a valid subscription to this content. To gain full access to the content and functionality of the AdisInsight database try one of the following. ...
Tetracaine 2-Dimethylamino) p-butylaminobenzoate; 2-dimethylaminoethylphenol-2-Dimethylamino-p-butylaminobenzoate; 2- (Dimethylamino) (Butylamino) -benzoicaci2- (dimethylamino) ethylester; amethocaine; Anetain CAS: 94-24-6 MF: C15H24N2O2 MW: 264.36...
Comments: This was the largest randomized clinical trial to date (n=116) to evaluate the use of topical anesthetics for corneal abrasions. There was no significant difference in healing between the two groups. However, only 93 patients returned for the primary outcome of follow-up at 48 hours.. Another problem was the large number of patients with retained rust rings (13-tetracaine and 10-placebo). This was unanticipated and made it challenging to analyze the data.. The study was underpowered to detect a difference in efficacy between the two groups both in 100mm-VAS pain scale. This represents a common limitations to randomized control trials. They are powered for the primary outcome not for the secondary outcome. However, their goal was to look at safety and that did not show a difference at 48hrs, 1-week or 1-month.. Patients self rated their pain about 50/100 on the VAS. Within 12 hours both groups had dropped to below 10 and at 24 hours approached zero. This speaks to the amazing healing ...
Purpose : Previously, we have shown that female mice exhibit a more severe dry eye phenotype following lacrimal gland excision (LGE) induced dry eye, as evidenced by increased fluorescein scores and cornea epithelial apoptosis. Signs of ocular discomfort and pain are the most common symptoms of dry eye disease. The aim of the present study was to determine whether sex differences are also observed following LGE using specific assays to assess pain and anxiety-like behaviors. Methods : Male and female C57BL/6 mice were obtained from Jackson Labs. Under isoflurane, a unilateral LGE was performed, excising either the left extraorbital gland, or both the extraorbital and intraorbital glands. For SHAM surgeries, incisions were made to partially expose both the extra- and intraorbital glands. Eye closure (squinting) was measured using a ratio consisting of the height of the gap between the upper and lower eyelids and the distance separating the two canthi. The topical anesthetic tetracaine (0.5% in ...
Quality Chinese Factroy Supply 99% Pure Tetracaine Hydrochloride Powder - find quality local anesthesia, Organic Intermediate & local anesthesia from Guangzhou Tengyue Chemical Co., Ltd. of China Suppliers - 167966707.
Sprawdź ile zapłacisz za lek butamben/tetracaine/benzocaine liquid w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie zniżki Ci przysługują.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Our company is specialized in the import and export of raw materials of chemical products. High purity, good color. Our company specializes in producing the following : Tetracaine Hydrochloride CAS:136-47-0 Anna Wpp: 8613171893220 Wickr:anna2026 Email:[email protected]
Impurities in pharmaceuticals are the chemicals that remain with the active pharmaceutical ingredients (APIs), or develop during formulation, or upon aging of both API and formulated APIs to medicines. The control of pharmaceutical impurities is currently a critical issue to the pharmaceutical industry.
Tetracaine hydrochloride ≥99%; CAS Number: 136-47-0; Synonym: 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester, Amethocaine hydrochloride; Linear Formula: C15H24N2O2 · HCl; find Sigma-Aldrich-T7508 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
Product Name: Tetracaine CAS: 94-24-6 MF: C15H24N2O2 MW: 264.36 EINECS: 202-316-6 storage temp.: 2-8°C Usage: analgesic Storage: Store under refrigeration.
Find the Blink Price & Information for tetracaine HCl - as low as $16.57 - pick up at your pharmacy (Rite Aid, Walmart & more). Price transparency and up to 80% savings.
This is EM Cases Journal Jam Podcast 6 - Outpatient Topical Anesthetics for Corneal Abrasions. Ive been told countless times by ophthalmologists and other colleagues NEVER to prescribe topical anesthetics for corneal abrasion patients, with the reason being largely theoretical - that tetracaine and the like will inhibit re-epithelialization and therefore delay epithelial healing as well as decrease corneal sensation, resulting in corneal ulcers. With prolonged use of outpatient topical anesthetics for corneal abrasions, corneal opacification could develop leading to decreased vision. Now this might be true for the tetracaine abuser who pours the stuff in their eye for weeks on end, but when we look at the literature for toxic effects of using topical anesthetics in the short term, there is no evidence for any clinically important detrimental outcomes. Should we ignore the dogma and use tetracaine anyway? Is there evidence that the use of topical anesthetics after corneal abrasions is safe and ...
We studied the effects of various beta-adrenoceptor (beta AR) antagonists and local anesthetics (LAs), i.e. substances possessing one basic and one lipophilic domain each, on activation of regulatory heterotrimeric guanine nucleotide-binding proteins (G-proteins). In membranes of differentiated HL-60 cells, propranolol activated high-affinity GTP hydrolysis with a half-maximal effect at 0.19 mM and a maximum at 1 mM. There was a close correlation between the log Q values (logarithm of the octanol: water partition coefficient) of beta AR antagonists and the logarithm of their effectiveness at activating GTPase (EC 3.6.1.-) in HL-60 membranes. The lipophilic LA, tetracaine, was also an effective activator of GTPase in HL-60 membranes, whereas more hydrophilic LAs were less stimulatory (bupivacaine and lidocaine) or even inhibitory (procaine). Propranolol and tetracaine also stimulated binding of guanosine 5-O-[3-thio]triphosphate (GTP[gamma S]) to HL-60 membranes, but their stimulatory effects on ...
ଟେଟ୍ରାକେନ (ଇଂରାଜୀ ଭାଷାରେ Tetracaine, ଅନ୍ୟ ନାମ ଆମେଥୋକେନ/amethocaine) ଏକ ସ୍ଥାନୀୟ ନିଶ୍ଚେତକ (local anesthetic) ଯାହା ଆଖି, ନାକ ଓ ଗଳାରେ ବ୍ୟବ‌ହାର କରାଯାଏ । [୧] ଶିରାଭ୍ୟନ୍ତର (intravenous) ନିଶ୍ଚେତକ ଦେବା ପୂର୍ବରୁ ମଧ୍ୟ ଏହା ଦିଆଯାଇପାରେ ।[୨] ଏହା ଏକ ତରଳ ପଦାର୍ଥ ଆକାରରେ ଲଗାଯାଏ । ଆଖିରେ ପ୍ରୟୋଗ କଲେ ୩୦ ସେକେଣ୍ଡ ମଧ୍ୟରେ ଏହା କାର୍ଯ୍ୟକ୍ଷମ ହୋଇ ୧୫ ମିନିଟ ପର୍ଯ୍ୟନ୍ତ ରହେ ।[୧] ଟେଟ୍ରାକେନର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସାଧାରଣତଃ ତାହା ଲଗାଯିବା ସ୍ଥାନରେ ଅଳ୍ପ ସମୟ ...
Strong-acting topical anesthetic used in local dermatological, ophthalmologic, oropharyngeal and urological anesthesia. Its use in epidural anesthesia is very rare. Since the last update we have not found any published data on its excretion in breast milk. Topical anesthetics (dermatological and stomatological preparations) when well applied have very low systemic absorption so that levels in plasma and, therefore, in breastmilk are zero or insignificant. Absorption is possibly greater if applied to inflamed skin. The low cutaneous absorption, the rapid hydrolysis of tetracaine in the plasma and its rapid elimination (AEMPS 2014, Galderma 2012) contribute to the fact that after the application of cutaneous topical tetracaine the plasma levels are undetectable or very low (AEMPS 2014, Galderma 2012, Ogden 2008, Terndrup 1992, Mazumdar 1991). Therefore, it can be considered compatible with breastfeeding (Briggs 2017, Galderma 2012, Schaefer 2007 p632). It should not be applied over large areas or
Endo Pharmaceuticals Inc has released Synera (lidocaine 70 mg and tetracaine 70 mg), a topical anesthetic patch approved for use in patients aged 3 years and older (safety of Synera has been demonstrated in patients as young as 4 months old). Synera will be available in institutional settings to prevent pain from superficial venous access and superficial dermatologic procedures, such as excision, electrodessication, and shave biopsy.1 Although Synera is appropriate for use in both adult and pediatric populations, Endo Pharmaceuticals is especially aware of its need in hospitalized children. Patients less than 15 years old spend approximately 11.5 million days in the hospital. Endo Pharmaceuticals promotes Synera to prevent pain, thus increasing patient comfort and quality of care.1 Mechanism of Action Synera consists of an oil emulsion of lidocaine and tetracaine as a eutectic mixture. The active ingredients cause local anesthesia by blockade of the sodium ion channels that are required for ...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.. ...
If you have liver disease, talk with healthcare provider. • The patch may contain conducting metal. Remove patch before MRI. • Check medicines with healthcare provider. This medicine may not mix well with other medicines. • Do not put coverings (bandages, dressings, make-up) over the area unless told to do so by healthcare provider. • Use caution on skin where a large area is involved or where there are open wounds. • Tell healthcare provider if you are pregnant or plan on getting pregnant. • Tell healthcare provider if you are breast-feeding. ...
We isolated and characterized yeast mutants whose growth is sensitive to a local anestheticum tetracaine and, at the same time, temperature sensitive. These mutants were collectively called ,i,las,/i, mutants (,i,l,/i,ocal ,i,a,/i,nestheticum ,i,s,/i,ensitive). The ,i,las21,/i, mutants were analyzed in this study. The wild type ,i,LAS21,/i, gene was cloned by exploiting temperature sensitivity of the ,i,las21,/i, mutants and we found that ,i,LAS21,/i, encodes ORF YJL062w which has not been analyzed before. Las21p is putative membrane protein belonging to the major facilitator super family containing plural membrane spanning domains. Complete elimination of the ,i,LAS21,/i, ORF did not kill the cells but made their growth temperature sensitive. Interestingly, the complete loss of the ,i,LAS21,/i, gene canceled the sensitivity to tetracaine. The ability of the ,i,las21,/i, mutants to grow at a higher temperature was recovered in the various media containing an osmotic stabilizer or salts. ...
About Fagron Fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. As an R&D scientific pharmaceutical compounding supplier, Fagron wants to widen the therapeutic scope of the prescriber to enable tailor-made pharmaceutical care. Through its activities, Fagron supports the unique selling point of the pharmacist. ...
Stop using this medicine and check with your doctor right away if you have a skin rash, burning, stinging, swelling, or irritation of your skin. Do not use cosmetics or other skin care products on the treated skin areas. ...
OpenAnesthesia™ content is intended for educational purposes only and not intended as medical advice.. Reuse of OpenAnesthesia™ content for commercial purposes of any kind is prohibited. ...
We have emailed you at with instructions on how to set up a new password. If you do not receive an email in the next 24 hours, or if you misplace your new password, please contact:. ASA members: ...
Welcome to Chen Chems Co. Ltd. We are worldwide professional suppliers of pharmaceutical intermediate products. If you need someone you can trust w...
Minims Amethocaine is a medicine available in a number of countries worldwide. A list of US medications equivalent to Minims Amethocaine is available on the Drugs.com website.
Benzocaine 14%, Butamben 2%, Tetracaine HCl 2%) Cetacaine Gel is formulated to provide clinicians with the Cetacaine triple-ingredient formula in a gel form. Patients will know the difference because Cetacaine has been proven to be more effective than 20% Benzocaine alone. The fast acting, long-lasting formula can be applied easily wet surface tissues, and the gel consistency gives you more control during application. Cetacaine Gel reacts with the bodys temperature to absorb into the tissue where it is applied. Use Cetacaine gel to anesthetize prior to the administration of an injection, or for minor surgical or laser procedures. The unique pump-top jar keeps the contents safely enclosed to help protect the un- used portion from cross contamination. You simply depress the pump top to control the amount of Cetacaine Gel that is dispensed. 32 g. Rx only.. Cetacaine Gel is available in two flavors, Strawberry and Cool Mint.. Item # 0217 ...
Block-Aid Phase 1 Anesthetic (10 grams) 3% Lidocaine USP & 2% Tetracaine USP. For use on unbroken skin. Use only as directed.
Lidocaine in combination with tetracaine is available in a formulation that generates heat upon air exposure (Synera). This formulation may be useful in which one(s) of the following ...
Sustaine anesthetic with a special mixture of high concentration active ingredients - lidocaine, tetracaine and epinephrine - not only reduces the conduct of pain impulses from the skin, but also provides active narrowing of blood vessels, which reduces bleeding during traumatic procedures and reduces the risk of bruising and swelling after. Anesthetic is used only on already damaged skin, first you need to use pre-treatment anesthetic.. ...
This liquid anesthetic is packaged with an easy to use flip top. Nicknamed Super Juice by many professionals because of its super anesthetic power. This liquid anesthetic contains 4% lidocaine, 2% tetracaine, and 12% benzocaine. It is safe for use for all procedures other than eyeliner. Use it to remove your pre-proced
Blue Gel is the topical best Anesthetic for Microblading and Semi-Permanent Make up procedures. Fast Numbing for open skin only. 4 % lidocaine and 2% tetracaine. Size: 1oz
... glycidate pmk powder CAS 16648-44-5 bmk glycidate BMK powder CAS 59-46-1 Procaine CAS 94-09-7 Benzocaine CAS 94-24-6 Tetracaine ... Tetracaine CAS?94-24-6?with High Quality and Purity [email protected] ... CAS 16648-44-5 bmk glycidate BMK powder CAS 59-46-1 Procaine CAS 94-09-7 Benzocaine CAS 94-24-6 Tetracaine CAS 136-47-0 ...
High Purity 99% Tetracaine CAS 94-24-6 with Best Price in Large Stock. Contact me:. Whatsapp/Signal/Telegram: +86 13696545329. ... China High Quality Tetracaine CAS 94-24-6 with Favourable Price. Contact Us:. WhatsApp /Signal /Telegram:. +86 15377505767. ... High quality tetracaine cas 136-47-0 with low price. Telegram: 86 15256514739. Skype:live:.cid.ed6cece6cab096ea. WhatsApp:86 ...
Generalized bloody guards tetracaine throat, syndactyly stom en Asociación Astronomía UPM. deunuzuutokef ...
BLT cream contains three active ingredients: benzocaine, lidocaine, and tetracaine. It is effective in the numbing of the ...
Tetracaine Hcl, Tilmicosin, Dried Papaya, Chia Seed Drink, Coconuts, Hardwood Charcoal, Coconut Shell Charcoal, Coffee Beans, ...
Looking for online definition of tetracosactrin in the Medical Dictionary? tetracosactrin explanation free. What is tetracosactrin? Meaning of tetracosactrin medical term. What does tetracosactrin mean?
Full line distributor of Medical, Surgical and Laboratory Equipment and Supplies. Free Shipping Available! Representatives are standing by at 1-800-736-1743.
Tetracaine/ct [clinical Trial], Tetracaine/dt [drug Therapy], Treatment Outcome, Vickerstaff V ... tetracaine), Alendronic Acid/ct [clinical Trial], Alendronic Acid/dt [drug Therapy], Analgesia, Baclofen/ct [clinical Trial], ...
  • BLT cream contains three active ingredients: benzocaine, lidocaine, and tetracaine. (bellemeadrx.com)

No images available that match "tetracaine"